                               SEQUENCE LISTING

<110> CRISPR THERAPEUTICS AG
 
<120> MATERIALS AND METHODS FOR TREATMENT OF PAIN RELATED DISORDERS

<130> CT77-PCT / 170153PCT

<150> 62/358,769
<151> 2016-07-06

<150> 62/461,876
<151> 2017-02-22


<160> 76046 

<170> PatentIn version 3.5

<210> 1
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 1
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 2
<211> 4107
<212> DNA
<213> Streptococcus pyogenes

<400> 2
atggataaga aatactcaat aggcttagat atcggcacaa atagcgtcgg atgggcggtg       60

atcactgatg aatataaggt tccgtctaaa aagttcaagg ttctgggaaa tacagaccgc      120

cacagtatca aaaaaaatct tataggggct cttttatttg acagtggaga gacagcggaa      180

gcgactcgtc tcaaacggac agctcgtaga aggtatacac gtcggaagaa tcgtatttgt      240

tatctacagg agattttttc aaatgagatg gcgaaagtag atgatagttt ctttcatcga      300

cttgaagagt cttttttggt ggaagaagac aagaagcatg aacgtcatcc tatttttgga      360

aatatagtag atgaagttgc ttatcatgag aaatatccaa ctatctatca tctgcgaaaa      420

aaattggtag attctactga taaagcggat ttgcgcttaa tctatttggc cttagcgcat      480

atgattaagt ttcgtggtca ttttttgatt gagggagatt taaatcctga taatagtgat      540

gtggacaaac tatttatcca gttggtacaa acctacaatc aattatttga agaaaaccct      600

attaacgcaa gtggagtaga tgctaaagcg attctttctg cacgattgag taaatcaaga      660

cgattagaaa atctcattgc tcagctcccc ggtgagaaga aaaatggctt atttgggaat      720

ctcattgctt tgtcattggg tttgacccct aattttaaat caaattttga tttggcagaa      780

gatgctaaat tacagctttc aaaagatact tacgatgatg atttagataa tttattggcg      840

caaattggag atcaatatgc tgatttgttt ttggcagcta agaatttatc agatgctatt      900

ttactttcag atatcctaag agtaaatact gaaataacta aggctcccct atcagcttca      960

atgattaaac gctacgatga acatcatcaa gacttgactc ttttaaaagc tttagttcga     1020

caacaacttc cagaaaagta taaagaaatc ttttttgatc aatcaaaaaa cggatatgca     1080

ggttatattg atgggggagc tagccaagaa gaattttata aatttatcaa accaatttta     1140

gaaaaaatgg atggtactga ggaattattg gtgaaactaa atcgtgaaga tttgctgcgc     1200

aagcaacgga cctttgacaa cggctctatt ccccatcaaa ttcacttggg tgagctgcat     1260

gctattttga gaagacaaga agacttttat ccatttttaa aagacaatcg tgagaagatt     1320

gaaaaaatct tgacttttcg aattccttat tatgttggtc cattggcgcg tggcaatagt     1380

cgttttgcat ggatgactcg gaagtctgaa gaaacaatta ccccatggaa ttttgaagaa     1440

gttgtcgata aaggtgcttc agctcaatca tttattgaac gcatgacaaa ctttgataaa     1500

aatcttccaa atgaaaaagt actaccaaaa catagtttgc tttatgagta ttttacggtt     1560

tataacgaat tgacaaaggt caaatatgtt actgaaggaa tgcgaaaacc agcatttctt     1620

tcaggtgaac agaagaaagc cattgttgat ttactcttca aaacaaatcg aaaagtaacc     1680

gttaagcaat taaaagaaga ttatttcaaa aaaatagaat gttttgatag tgttgaaatt     1740

tcaggagttg aagatagatt taatgcttca ttaggtacct accatgattt gctaaaaatt     1800

attaaagata aagatttttt ggataatgaa gaaaatgaag atatcttaga ggatattgtt     1860

ttaacattga ccttatttga agatagggag atgattgagg aaagacttaa aacatatgct     1920

cacctctttg atgataaggt gatgaaacag cttaaacgtc gccgttatac tggttgggga     1980

cgtttgtctc gaaaattgat taatggtatt agggataagc aatctggcaa aacaatatta     2040

gattttttga aatcagatgg ttttgccaat cgcaatttta tgcagctgat ccatgatgat     2100

agtttgacat ttaaagaaga cattcaaaaa gcacaagtgt ctggacaagg cgatagttta     2160

catgaacata ttgcaaattt agctggtagc cctgctatta aaaaaggtat tttacagact     2220

gtaaaagttg ttgatgaatt ggtcaaagta atggggcggc ataagccaga aaatatcgtt     2280

attgaaatgg cacgtgaaaa tcagacaact caaaagggcc agaaaaattc gcgagagcgt     2340

atgaaacgaa tcgaagaagg tatcaaagaa ttaggaagtc agattcttaa agagcatcct     2400

gttgaaaata ctcaattgca aaatgaaaag ctctatctct attatctcca aaatggaaga     2460

gacatgtatg tggaccaaga attagatatt aatcgtttaa gtgattatga tgtcgatcac     2520

attgttccac aaagtttcct taaagacgat tcaatagaca ataaggtctt aacgcgttct     2580

gataaaaatc gtggtaaatc ggataacgtt ccaagtgaag aagtagtcaa aaagatgaaa     2640

aactattgga gacaacttct aaacgccaag ttaatcactc aacgtaagtt tgataattta     2700

acgaaagctg aacgtggagg tttgagtgaa cttgataaag ctggttttat caaacgccaa     2760

ttggttgaaa ctcgccaaat cactaagcat gtggcacaaa ttttggatag tcgcatgaat     2820

actaaatacg atgaaaatga taaacttatt cgagaggtta aagtgattac cttaaaatct     2880

aaattagttt ctgacttccg aaaagatttc caattctata aagtacgtga gattaacaat     2940

taccatcatg cccatgatgc gtatctaaat gccgtcgttg gaactgcttt gattaagaaa     3000

tatccaaaac ttgaatcgga gtttgtctat ggtgattata aagtttatga tgttcgtaaa     3060

atgattgcta agtctgagca agaaataggc aaagcaaccg caaaatattt cttttactct     3120

aatatcatga acttcttcaa aacagaaatt acacttgcaa atggagagat tcgcaaacgc     3180

cctctaatcg aaactaatgg ggaaactgga gaaattgtct gggataaagg gcgagatttt     3240

gccacagtgc gcaaagtatt gtccatgccc caagtcaata ttgtcaagaa aacagaagta     3300

cagacaggcg gattctccaa ggagtcaatt ttaccaaaaa gaaattcgga caagcttatt     3360

gctcgtaaaa aagactggga tccaaaaaaa tatggtggtt ttgatagtcc aacggtagct     3420

tattcagtcc tagtggttgc taaggtggaa aaagggaaat cgaagaagtt aaaatccgtt     3480

aaagagttac tagggatcac aattatggaa agaagttcct ttgaaaaaaa tccgattgac     3540

tttttagaag ctaaaggata taaggaagtt aaaaaagact taatcattaa actacctaaa     3600

tatagtcttt ttgagttaga aaacggtcgt aaacggatgc tggctagtgc cggagaatta     3660

caaaaaggaa atgagctggc tctgccaagc aaatatgtga attttttata tttagctagt     3720

cattatgaaa agttgaaggg tagtccagaa gataacgaac aaaaacaatt gtttgtggag     3780

cagcataagc attatttaga tgagattatt gagcaaatca gtgaattttc taagcgtgtt     3840

attttagcag atgccaattt agataaagtt cttagtgcat ataacaaaca tagagacaaa     3900

ccaatacgtg aacaagcaga aaatattatt catttattta cgttgacgaa tcttggagct     3960

cccgctgctt ttaaatattt tgatacaaca attgatcgta aacgatatac gtctacaaaa     4020

gaagttttag atgccactct tatccatcaa tccatcactg gtctttatga aacacgcatt     4080

gatttgagtc agctaggagg tgactga                                         4107


<210> 3
<211> 4107
<212> DNA
<213> Streptococcus pyogenes

<400> 3
atggacaaga agtactccat tgggctcgct atcggcacaa acagcgtcgg ctgggccgtc       60

attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc      120

cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa      180

gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc      240

tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg      300

ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc      360

aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag      420

aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat      480

atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat      540

gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg      600

atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg      660

cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat      720

cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa      780

gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc      840

cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt      900

ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt      960

atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga     1020

cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc     1080

ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg     1140

gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc     1200

aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac     1260

gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt     1320

gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc     1380

agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa cttcgaggaa     1440

gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa     1500

aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt     1560

tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg     1620

tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc     1680

gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc     1740

agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc     1800

attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc     1860

ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct     1920

catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg     1980

cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg     2040

gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac     2100

tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt     2160

cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc     2220

gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt     2280

atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg     2340

atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca     2400

gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg     2460

gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggctgct     2520

atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc     2580

gataaagcta gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa     2640

aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg     2700

actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag     2760

cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac     2820

accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct     2880

aagctggtct cagatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat     2940

taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa     3000

tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa     3060

atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc     3120

aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga     3180

ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc     3240

gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta     3300

cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc     3360

gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct     3420

tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc     3480

aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac     3540

tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag     3600

tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg     3660

cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc     3720

cactatgaaa agctcaaagg gtctcccgaa gataatgagc agaagcagct gttcgtggaa     3780

caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg     3840

atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag     3900

cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg     3960

cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag     4020

gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc     4080

gacctctctc agctcggtgg agactaa                                         4107


<210> 4
<211> 4140
<212> DNA
<213> Streptococcus pyogenes

<400> 4
atggacaaga agtactccat tgggctcgat atcggcacaa acagcgtcgg ctgggccgtc       60

attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc      120

cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa      180

gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc      240

tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg      300

ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc      360

aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag      420

aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat      480

atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat      540

gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg      600

atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg      660

cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat      720

cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa      780

gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc      840

cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt      900

ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt      960

atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga     1020

cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc     1080

ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg     1140

gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc     1200

aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac     1260

gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt     1320

gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc     1380

agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa cttcgaggaa     1440

gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa     1500

aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt     1560

tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg     1620

tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc     1680

gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc     1740

agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc     1800

attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc     1860

ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct     1920

catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg     1980

cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg     2040

gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac     2100

tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt     2160

cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc     2220

gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt     2280

atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg     2340

atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca     2400

gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg     2460

gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggatcat     2520

atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc     2580

gataaaaata gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa     2640

aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg     2700

actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag     2760

cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac     2820

accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct     2880

aagctggtct cagatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat     2940

taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa     3000

tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa     3060

atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc     3120

aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga     3180

ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc     3240

gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta     3300

cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc     3360

gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct     3420

tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc     3480

aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac     3540

tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag     3600

tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg     3660

cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc     3720

cactatgaaa agctcaaagg gtctcccgaa gataatgagc agaagcagct gttcgtggaa     3780

caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg     3840

atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag     3900

cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg     3960

cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag     4020

gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc     4080

gacctctctc agctcggtgg agacagcagg gctgacccca agaagaagag gaaggtgtga     4140


<210> 5
<211> 4200
<212> DNA
<213> Streptococcus pyogenes

<400> 5
atggacaaga agtactccat tgggctcgat atcggcacaa acagcgtcgg ctgggccgtc       60

attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc      120

cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa      180

gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc      240

tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg      300

ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc      360

aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag      420

aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat      480

atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat      540

gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg      600

atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg      660

cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat      720

cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa      780

gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc      840

cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt      900

ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt      960

atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga     1020

cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc     1080

ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg     1140

gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc     1200

aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac     1260

gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt     1320

gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc     1380

agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa cttcgaggaa     1440

gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa     1500

aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt     1560

tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg     1620

tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc     1680

gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc     1740

agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc     1800

attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc     1860

ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct     1920

catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg     1980

cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg     2040

gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac     2100

tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt     2160

cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc     2220

gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt     2280

atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg     2340

atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca     2400

gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg     2460

gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggatcat     2520

atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc     2580

gataaaaata gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa     2640

aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg     2700

actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag     2760

cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac     2820

accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct     2880

aagctggtct cagatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat     2940

taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa     3000

tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa     3060

atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc     3120

aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga     3180

ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc     3240

gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta     3300

cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc     3360

gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct     3420

tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc     3480

aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac     3540

tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag     3600

tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg     3660

cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc     3720

cactatgaaa agctcaaagg gtctcccgaa gataatgagc agaagcagct gttcgtggaa     3780

caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg     3840

atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag     3900

cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg     3960

cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag     4020

gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc     4080

gacctctctc agctcggtgg agacgcggcc gcagatccaa aaaagaagag aaaggtagat     4140

ccaaaaaaga agagaaaggt agatccaaaa aagaagagaa aggtagatac ggccgcatag     4200


<210> 6
<211> 4326
<212> DNA
<213> Streptococcus pyogenes

<400> 6
atggacaaga agtactccat tgggctcgct atcggcacaa acagcgtcgg ctgggccgtc       60

attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc      120

cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa      180

gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc      240

tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg      300

ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc      360

aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag      420

aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat      480

atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat      540

gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg      600

atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg      660

cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat      720

cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa      780

gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc      840

cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt      900

ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt      960

atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga     1020

cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc     1080

ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg     1140

gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc     1200

aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac     1260

gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt     1320

gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc     1380

agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa cttcgaggaa     1440

gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa     1500

aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt     1560

tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg     1620

tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc     1680

gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc     1740

agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc     1800

attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc     1860

ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct     1920

catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg     1980

cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg     2040

gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac     2100

tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt     2160

cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc     2220

gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt     2280

atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg     2340

atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca     2400

gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg     2460

gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggctgct     2520

atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc     2580

gataaagcta gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa     2640

aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg     2700

actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag     2760

cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac     2820

accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct     2880

aagctggtct cagatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat     2940

taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa     3000

tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa     3060

atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc     3120

aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga     3180

ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc     3240

gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta     3300

cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc     3360

gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct     3420

tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc     3480

aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac     3540

tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag     3600

tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg     3660

cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc     3720

cactatgaaa agctcaaagg gtctcccgaa gataatgagc agaagcagct gttcgtggaa     3780

caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg     3840

atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag     3900

cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg     3960

cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag     4020

gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc     4080

gacctctctc agctcggtgg agacagcagg gctgacccca agaagaagag gaaggtggag     4140

gccagcggtt ccggacgggc tgacgcattg gacgattttg atctggatat gctgggaagt     4200

gacgccctcg atgattttga ccttgacatg cttggttcgg atgcccttga tgactttgac     4260

ctcgacatgc tcggcagtga cgcccttgat gatttcgacc tggacatgct gattaactct     4320

agatga                                                                4326


<210> 7
<211> 4359
<212> DNA
<213> Streptococcus pyogenes

<400> 7
atgcccaaga agaagaggaa ggtgggaagg gggatggaca agaagtactc cattgggctc       60

gctatcggca caaacagcgt cggctgggcc gtcattacgg acgagtacaa ggtgccgagc      120

aaaaaattca aagttctggg caataccgat cgccacagca taaagaagaa cctcattggc      180

gccctcctgt tcgactccgg ggagacggcc gaagccacgc ggctcaaaag aacagcacgg      240

cgcagatata cccgcagaaa gaatcggatc tgctacctgc aggagatctt tagtaatgag      300

atggctaagg tggatgactc tttcttccat aggctggagg agtccttttt ggtggaggag      360

gataaaaagc acgagcgcca cccaatcttt ggcaatatcg tggacgaggt ggcgtaccat      420

gaaaagtacc caaccatata tcatctgagg aagaagcttg tagacagtac tgataaggct      480

gacttgcggt tgatctatct cgcgctggcg catatgatca aatttcgggg acacttcctc      540

atcgaggggg acctgaaccc agacaacagc gatgtcgaca aactctttat ccaactggtt      600

cagacttaca atcagctttt cgaagagaac ccgatcaacg catccggagt tgacgccaaa      660

gcaatcctga gcgctaggct gtccaaatcc cggcggctcg aaaacctcat cgcacagctc      720

cctggggaga agaagaacgg cctgtttggt aatcttatcg ccctgtcact cgggctgacc      780

cccaacttta aatctaactt cgacctggcc gaagatgcca agcttcaact gagcaaagac      840

acctacgatg atgatctcga caatctgctg gcccagatcg gcgaccagta cgcagacctt      900

tttttggcgg caaagaacct gtcagacgcc attctgctga gtgatattct gcgagtgaac      960

acggagatca ccaaagctcc gctgagcgct agtatgatca agcgctatga tgagcaccac     1020

caagacttga ctttgctgaa ggcccttgtc agacagcaac tgcctgagaa gtacaaggaa     1080

attttcttcg atcagtctaa aaatggctac gccggataca ttgacggcgg agcaagccag     1140

gaggaatttt acaaatttat taagcccatc ttggaaaaaa tggacggcac cgaggagctg     1200

ctggtaaagc ttaacagaga agatctgttg cgcaaacagc gcactttcga caatggaagc     1260

atcccccacc agattcacct gggcgaactg cacgctatcc tcaggcggca agaggatttc     1320

tacccctttt tgaaagataa cagggaaaag attgagaaaa tcctcacatt tcggataccc     1380

tactatgtag gccccctcgc ccggggaaat tccagattcg cgtggatgac tcgcaaatca     1440

gaagagacca tcactccctg gaacttcgag gaagtcgtgg ataagggggc ctctgcccag     1500

tccttcatcg aaaggatgac taactttgat aaaaatctgc ctaacgaaaa ggtgcttcct     1560

aaacactctc tgctgtacga gtacttcaca gtttataacg agctcaccaa ggtcaaatac     1620

gtcacagaag ggatgagaaa gccagcattc ctgtctggag agcagaagaa agctatcgtg     1680

gacctcctct tcaagacgaa ccggaaagtt accgtgaaac agctcaaaga agactatttc     1740

aaaaagattg aatgtttcga ctctgttgaa atcagcggag tggaggatcg cttcaacgca     1800

tccctgggaa cgtatcacga tctcctgaaa atcattaaag acaaggactt cctggacaat     1860

gaggagaacg aggacattct tgaggacatt gtcctcaccc ttacgttgtt tgaagatagg     1920

gagatgattg aagaacgctt gaaaacttac gctcatctct tcgacgacaa agtcatgaaa     1980

cagctcaaga ggcgccgata tacaggatgg gggcggctgt caagaaaact gatcaatggg     2040

atccgagaca agcagagtgg aaagacaatc ctggattttc ttaagtccga tggatttgcc     2100

aaccggaact tcatgcagtt gatccatgat gactctctca cctttaagga ggacatccag     2160

aaagcacaag tttctggcca gggggacagt cttcacgagc acatcgctaa tcttgcaggt     2220

agcccagcta tcaaaaaggg aatactgcag accgttaagg tcgtggatga actcgtcaaa     2280

gtaatgggaa ggcataagcc cgagaatatc gttatcgaga tggcccgaga gaaccaaact     2340

acccagaagg gacagaagaa cagtagggaa aggatgaaga ggattgaaga gggtataaaa     2400

gaactggggt cccaaatcct taaggaacac ccagttgaaa acacccagct tcagaatgag     2460

aagctctacc tgtactacct gcagaacggc agggacatgt acgtggatca ggaactggac     2520

atcaatcggc tctccgacta cgacgtggct gctatcgtgc cccagtcttt tctcaaagat     2580

gattctattg ataataaagt gttgacaaga tccgataaag ctagagggaa gagtgataac     2640

gtcccctcag aagaagttgt caagaaaatg aaaaattatt ggcggcagct gctgaacgcc     2700

aaactgatca cacaacggaa gttcgataat ctgactaagg ctgaacgagg tggcctgtct     2760

gagttggata aagccggctt catcaaaagg cagcttgttg agacacgcca gatcaccaag     2820

cacgtggccc aaattctcga ttcacgcatg aacaccaagt acgatgaaaa tgacaaactg     2880

attcgagagg tgaaagttat tactctgaag tctaagctgg tctcagattt cagaaaggac     2940

tttcagtttt ataaggtgag agagatcaac aattaccacc atgcgcatga tgcctacctg     3000

aatgcagtgg taggcactgc acttatcaaa aaatatccca agcttgaatc tgaatttgtt     3060

tacggagact ataaagtgta cgatgttagg aaaatgatcg caaagtctga gcaggaaata     3120

ggcaaggcca ccgctaagta cttcttttac agcaatatta tgaatttttt caagaccgag     3180

attacactgg ccaatggaga gattcggaag cgaccactta tcgaaacaaa cggagaaaca     3240

ggagaaatcg tgtgggacaa gggtagggat ttcgcgacag tccggaaggt cctgtccatg     3300

ccgcaggtga acatcgttaa aaagaccgaa gtacagaccg gaggcttctc caaggaaagt     3360

atcctcccga aaaggaacag cgacaagctg atcgcacgca aaaaagattg ggaccccaag     3420

aaatacggcg gattcgattc tcctacagtc gcttacagtg tactggttgt ggccaaagtg     3480

gagaaaggga agtctaaaaa actcaaaagc gtcaaggaac tgctgggcat cacaatcatg     3540

gagcgatcaa gcttcgaaaa aaaccccatc gactttctcg aggcgaaagg atataaagag     3600

gtcaaaaaag acctcatcat taagcttccc aagtactctc tctttgagct tgaaaacggc     3660

cggaaacgaa tgctcgctag tgcgggcgag ctgcagaaag gtaacgagct ggcactgccc     3720

tctaaatacg ttaatttctt gtatctggcc agccactatg aaaagctcaa agggtctccc     3780

gaagataatg agcagaagca gctgttcgtg gaacaacaca aacactacct tgatgagatc     3840

atcgagcaaa taagcgaatt ctccaaaaga gtgatcctcg ccgacgctaa cctcgataag     3900

gtgctttctg cttacaataa gcacagggat aagcccatca gggagcaggc agaaaacatt     3960

atccacttgt ttactctgac caacttgggc gcgcctgcag ccttcaagta cttcgacacc     4020

accatagaca gaaagcggta cacctctaca aaggaggtcc tggacgccac actgattcat     4080

cagtcaatta cggggctcta tgaaacaaga atcgacctct ctcagctcgg tggagacagc     4140

agggctgacc ccaagaagaa gaggaaggtg gaggccagcg gttccggacg ggctgacgca     4200

ttggacgatt ttgatctgga tatgctggga agtgacgccc tcgatgattt tgaccttgac     4260

atgcttggtt cggatgccct tgatgacttt gacctcgaca tgctcggcag tgacgccctt     4320

gatgatttcg acctggacat gctgattaac tctagatga                            4359


<210> 8
<211> 1409
<212> PRT
<213> Streptococcus thermophiles

<400> 8
Met Leu Phe Asn Lys Cys Ile Ile Ile Ser Ile Asn Leu Asp Phe Ser 
1               5                   10                  15      


Asn Lys Glu Lys Cys Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile 
            20                  25                  30          


Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Asn Tyr Lys Val 
        35                  40                  45              


Pro Ser Lys Lys Met Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile 
    50                  55                  60                  


Lys Lys Asn Leu Leu Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala 
65                  70                  75                  80  


Glu Gly Arg Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg 
                85                  90                  95      


Arg Asn Arg Ile Leu Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala 
            100                 105                 110         


Thr Leu Asp Asp Ala Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val 
        115                 120                 125             


Pro Asp Asp Lys Arg Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val 
    130                 135                 140                 


Glu Glu Lys Val Tyr His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg 
145                 150                 155                 160 


Lys Tyr Leu Ala Asp Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr 
                165                 170                 175     


Leu Ala Leu Ala His Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu 
            180                 185                 190         


Gly Glu Phe Asn Ser Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp 
        195                 200                 205             


Phe Leu Asp Thr Tyr Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu 
    210                 215                 220                 


Asn Ser Lys Gln Leu Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu 
225                 230                 235                 240 


Glu Lys Lys Asp Arg Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser 
                245                 250                 255     


Gly Ile Phe Ser Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp 
            260                 265                 270         


Phe Arg Lys Cys Phe Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser 
        275                 280                 285             


Lys Glu Ser Tyr Asp Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly 
    290                 295                 300                 


Asp Asp Tyr Ser Asp Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala 
305                 310                 315                 320 


Ile Leu Leu Ser Gly Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala 
                325                 330                 335     


Pro Leu Ser Ser Ala Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp 
            340                 345                 350         


Leu Ala Leu Leu Lys Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr 
        355                 360                 365             


Asn Glu Val Phe Lys Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile 
    370                 375                 380                 


Asp Gly Lys Thr Asn Gln Glu Asp Phe Tyr Val Tyr Leu Lys Asn Leu 
385                 390                 395                 400 


Leu Ala Glu Phe Glu Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg 
                405                 410                 415     


Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro 
            420                 425                 430         


Tyr Gln Ile His Leu Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala 
        435                 440                 445             


Lys Phe Tyr Pro Phe Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile 
    450                 455                 460                 


Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn 
465                 470                 475                 480 


Ser Asp Phe Ala Trp Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro 
                485                 490                 495     


Trp Asn Phe Glu Asp Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe 
            500                 505                 510         


Ile Asn Arg Met Thr Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val 
        515                 520                 525             


Leu Pro Lys His Ser Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu 
    530                 535                 540                 


Leu Thr Lys Val Arg Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe 
545                 550                 555                 560 


Leu Asp Ser Lys Gln Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp 
                565                 570                 575     


Lys Arg Lys Val Thr Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile 
            580                 585                 590         


Tyr Gly Tyr Asp Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn 
        595                 600                 605             


Ser Ser Leu Ser Thr Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys 
    610                 615                 620                 


Glu Phe Leu Asp Asp Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile 
625                 630                 635                 640 


His Thr Leu Thr Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu 
                645                 650                 655     


Ser Lys Phe Glu Asn Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser 
            660                 665                 670         


Arg Arg His Tyr Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn 
        675                 680                 685             


Gly Ile Arg Asp Glu Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile 
    690                 695                 700                 


Asp Asp Gly Ile Ser Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
705                 710                 715                 720 


Ala Leu Ser Phe Lys Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp 
                725                 730                 735     


Glu Asp Lys Gly Asn Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser 
            740                 745                 750         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu 
        755                 760                 765             


Leu Val Lys Val Met Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu 
    770                 775                 780                 


Met Ala Arg Glu Asn Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln 
785                 790                 795                 800 


Gln Arg Leu Lys Arg Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys 
                805                 810                 815     


Ile Leu Lys Glu Asn Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn 
            820                 825                 830         


Ala Leu Gln Asn Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys 
        835                 840                 845             


Asp Met Tyr Thr Gly Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr 
    850                 855                 860                 


Asp Ile Asp His Ile Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile 
865                 870                 875                 880 


Asp Asn Lys Val Leu Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp 
                885                 890                 895     


Asp Phe Pro Ser Leu Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr 
            900                 905                 910         


Gln Leu Leu Lys Ser Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu 
        915                 920                 925             


Thr Lys Ala Glu Arg Gly Gly Leu Leu Pro Glu Asp Lys Ala Gly Phe 
    930                 935                 940                 


Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala 
945                 950                 955                 960 


Arg Leu Leu Asp Glu Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg 
                965                 970                 975     


Ala Val Arg Thr Val Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser 
            980                 985                 990         


Gln Phe Arg Lys Asp Phe Glu Leu  Tyr Lys Val Arg Glu  Ile Asn Asp 
        995                 1000                 1005             


Phe His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Ile Ala Ser 
    1010                 1015                 1020             


Ala Leu  Leu Lys Lys Tyr Pro  Lys Leu Glu Pro Glu  Phe Val Tyr 
    1025                 1030                 1035             


Gly Asp  Tyr Pro Lys Tyr Asn  Ser Phe Arg Glu Arg  Lys Ser Ala 
    1040                 1045                 1050             


Thr Glu  Lys Val Tyr Phe Tyr  Ser Asn Ile Met Asn  Ile Phe Lys 
    1055                 1060                 1065             


Lys Ser  Ile Ser Leu Ala Asp  Gly Arg Val Ile Glu  Arg Pro Leu 
    1070                 1075                 1080             


Ile Glu  Val Asn Glu Glu Thr  Gly Glu Ser Val Trp  Asn Lys Glu 
    1085                 1090                 1095             


Ser Asp  Leu Ala Thr Val Arg  Arg Val Leu Ser Tyr  Pro Gln Val 
    1100                 1105                 1110             


Asn Val  Val Lys Lys Val Glu  Glu Gln Asn His Gly  Leu Asp Arg 
    1115                 1120                 1125             


Gly Lys  Pro Lys Gly Leu Phe  Asn Ala Asn Leu Ser  Ser Lys Pro 
    1130                 1135                 1140             


Lys Pro  Asn Ser Asn Glu Asn  Leu Val Gly Ala Lys  Glu Tyr Leu 
    1145                 1150                 1155             


Asp Pro  Lys Lys Tyr Gly Gly  Tyr Ala Gly Ile Ser  Asn Ser Phe 
    1160                 1165                 1170             


Ala Val  Leu Val Lys Gly Thr  Ile Glu Lys Gly Ala  Lys Lys Lys 
    1175                 1180                 1185             


Ile Thr  Asn Val Leu Glu Phe  Gln Gly Ile Ser Ile  Leu Asp Arg 
    1190                 1195                 1200             


Ile Asn  Tyr Arg Lys Asp Lys  Leu Asn Phe Leu Leu  Glu Lys Gly 
    1205                 1210                 1215             


Tyr Lys  Asp Ile Glu Leu Ile  Ile Glu Leu Pro Lys  Tyr Ser Leu 
    1220                 1225                 1230             


Phe Glu  Leu Ser Asp Gly Ser  Arg Arg Met Leu Ala  Ser Ile Leu 
    1235                 1240                 1245             


Ser Thr  Asn Asn Lys Arg Gly  Glu Ile His Lys Gly  Asn Gln Ile 
    1250                 1255                 1260             


Phe Leu  Ser Gln Lys Phe Val  Lys Leu Leu Tyr His  Ala Lys Arg 
    1265                 1270                 1275             


Ile Ser  Asn Thr Ile Asn Glu  Asn His Arg Lys Tyr  Val Glu Asn 
    1280                 1285                 1290             


His Lys  Lys Glu Phe Glu Glu  Leu Phe Tyr Tyr Ile  Leu Glu Phe 
    1295                 1300                 1305             


Asn Glu  Asn Tyr Val Gly Ala  Lys Lys Asn Gly Lys  Leu Leu Asn 
    1310                 1315                 1320             


Ser Ala  Phe Gln Ser Trp Gln  Asn His Ser Ile Asp  Glu Leu Cys 
    1325                 1330                 1335             


Ser Ser  Phe Ile Gly Pro Thr  Gly Ser Glu Arg Lys  Gly Leu Phe 
    1340                 1345                 1350             


Glu Leu  Thr Ser Arg Gly Ser  Ala Ala Asp Phe Glu  Phe Leu Gly 
    1355                 1360                 1365             


Val Lys  Ile Pro Arg Tyr Arg  Asp Tyr Thr Pro Ser  Ser Leu Leu 
    1370                 1375                 1380             


Lys Asp  Ala Thr Leu Ile His  Gln Ser Val Thr Gly  Leu Tyr Glu 
    1385                 1390                 1395             


Thr Arg  Ile Asp Leu Ala Lys  Leu Gly Glu Gly 
    1400                 1405                 


<210> 9
<211> 4167
<212> DNA
<213> Streptococcus thermophiles

<400> 9
atgactaagc catactcaat tggacttgat attggaacga atagtgttgg atgggctgta       60

ataactgata attacaaggt tccgtctaaa aaaatgaaag tcttaggaaa tacgagtaaa      120

aagtatatca aaaagaacct gttaggtgta ttactctttg actctggaat cacagcagaa      180

ggaagaagat tgaagcgtac tgcaagaaga cgttatacta gacgccgtaa tcgtatcctt      240

tatttgcagg aaatttttag cacggagatg gctacattag atgatgcttt ctttcaaaga      300

cttgacgatt cgtttttagt tcctgatgat aaacgtgata gtaagtatcc gatatttgga      360

aacttagtag aagaaaaagt ctatcatgat gaatttccaa ctatctatca tttaaggaaa      420

tatttagcag atagtactaa aaaagcagat ttgcgtctag tttatcttgc attggctcat      480

atgattaaat atagaggtca cttcttaatt gaaggagagt ttaattcaaa aaataatgat      540

attcagaaga attttcaaga ctttttggac acttataatg ctatttttga atcggattta      600

tcacttgaga atagtaaaca acttgaggaa attgttaaag ataagattag taaattagaa      660

aagaaagatc gtattttaaa actcttccct ggggagaaga attcggggat tttttcagag      720

tttctaaagt tgattgtagg aaatcaagct gattttagga aatgttttaa tttagacgaa      780

aaagcctcct tacatttttc caaagaaagc tatgatgaag atttagagac tttgttaggt      840

tatattggag atgattacag tgatgtcttt ctcaaagcaa agaaacttta tgatgctatt      900

cttttatcgg gttttctgac tgtaactgat aatgagacag aagcacctct ctcttctgct      960

atgataaagc gatataatga acacaaagaa gatttagcgt tactaaagga atatataaga     1020

aatatttcac taaaaacgta taatgaagta tttaaagatg acaccaaaaa tggttatgct     1080

ggttatattg atggaaaaac aaatcaggaa gatttctacg tatatctaaa aaacctattg     1140

gctgaatttg aaggtgcgga ttattttctt gaaaaaattg atcgagaaga ttttttgaga     1200

aagcaacgta catttgacaa tggttcgata ccatatcaga ttcatcttca agaaatgaga     1260

gcaattcttg ataagcaagc taaattttat cctttcttgg ctaaaaataa agaaagaatc     1320

gagaagattt taaccttccg aattccttat tatgtaggtc cacttgcgag agggaatagt     1380

gattttgcct ggtcaataag aaaacgaaat gaaaaaatta caccttggaa ttttgaggac     1440

gttattgaca aagaatcttc ggcagaggct ttcattaatc gaatgactag ttttgatttg     1500

tatttgccag aagagaaggt acttccaaag catagtctct tatacgaaac ttttaatgta     1560

tataatgaat taacaaaagt tagatttatt gccgaaagta tgagagatta tcaattttta     1620

gatagtaagc agaagaaaga tattgttaga ctttatttta aagataaaag gaaagttact     1680

gataaggata ttattgaata tttacatgca atttatgggt atgatggaat tgaattaaaa     1740

ggcatagaga aacagtttaa ttctagttta tctacttatc acgatctttt aaatattatt     1800

aatgataaag agtttttgga tgatagttca aatgaagcga ttatcgaaga aattatccat     1860

actttgacaa tttttgaaga tagagagatg ataaaacaac gtctttcaaa atttgagaat     1920

atattcgata aatccgtttt gaaaaagtta tctcgtagac attacactgg ctggggtaag     1980

ttatctgcta agcttattaa tggtattcga gatgaaaaat ctggtaatac tattcttgat     2040

tacttaattg atgatggtat ttctaaccgt aatttcatgc aacttattca cgatgatgct     2100

ctttctttta aaaagaagat acagaaagca caaattattg gtgacgaaga taaaggtaat     2160

attaaagagg tcgttaagtc tttgccaggt agtcctgcga ttaaaaaagg tattttacaa     2220

agcataaaaa ttgtagatga attggtcaaa gtaatgggag gaagaaaacc cgagtcaatt     2280

gttgttgaga tggctcgtga aaatcaatat accaatcaag gtaagtctaa ttcccaacaa     2340

cgcttgaaac gtttagaaaa atctctcaaa gagttaggta gtaagatact taaggaaaat     2400

attcctgcaa aactttctaa aatagacaat aacgcacttc aaaatgatcg actttactta     2460

tactatcttc aaaatggaaa agatatgtat accggagatg atttagatat tgatagatta     2520

agtaattatg atattgatca tattattcct caagcttttt tgaaagataa ttctattgac     2580

aataaagtac ttgtttcatc tgctagtaac cgtggtaaat cagatgattt tccaagttta     2640

gaggttgtca aaaaaagaaa gacattttgg tatcaattat tgaaatcaaa attaatttct     2700

caacgaaaat ttgataatct gacaaaagct gaacggggag gattgttacc tgaggacaaa     2760

gctggtttta ttcaacgcca gttggttgaa acacgtcaaa taacaaaaca tgtagctcgt     2820

ttacttgatg agaaatttaa taataaaaaa gatgaaaata atagagcggt acgaacagta     2880

aaaattatta ccttgaaatc taccttagtt tctcaatttc gtaaggattt tgaactttat     2940

aaagttcgtg aaatcaatga ttttcatcat gctcatgatg cttacttgaa tgccgttata     3000

gcaagtgctt tacttaagaa ataccctaaa ctagagccag aatttgtgta cggtgattat     3060

ccaaaataca atagttttag agaaagaaag tccgctacag aaaaggtata tttctattca     3120

aatatcatga atatctttaa aaaatctatt tctttagctg atggtagagt tattgaaaga     3180

ccacttattg aggtaaatga ggagaccggc gaatccgttt ggaataaaga atctgattta     3240

gcaactgtaa ggagagtact ctcttatccg caagtaaatg ttgtgaaaaa agttgaggaa     3300

cagaatcacg gattggatag aggaaaacca aagggattgt ttaatgcaaa tctttcctca     3360

aagccaaaac caaatagtaa tgaaaattta gtaggtgcta aagagtatct tgaccccaaa     3420

aagtatgggg ggtatgctgg aatttctaat tcttttgctg ttcttgttaa agggacaatt     3480

gaaaaaggtg ctaagaaaaa aataacaaat gtactagaat ttcaaggtat ttctatttta     3540

gataggatta attatagaaa agataaactt aattttttac ttgaaaaagg ttataaagat     3600

attgagttaa ttattgaact acctaaatat agtttatttg aactttcaga tggttcacgt     3660

cgtatgttgg ctagtatttt gtcaacgaat aataagaggg gagagattca caaaggaaat     3720

cagatttttc tttcacagaa gtttgtgaaa ttactttatc atgctaagag aataagtaac     3780

acaattaatg agaatcatag aaaatatgtt gagaaccata aaaaagagtt tgaagaatta     3840

ttttactaca ttcttgagtt taatgagaat tatgttggag ctaaaaagaa tggtaaactt     3900

ttaaactctg cctttcaatc ttggcaaaat catagtatag atgaactctg tagtagtttt     3960

ataggaccta ccggaagtga aagaaagggg ctatttgaat taacctctcg tggaagtgct     4020

gctgattttg aatttttagg tgttaaaatt ccaaggtata gagactatac cccatcatcc     4080

ctattaaaag atgccacact tattcatcaa tctgttacag gcctctatga aacacgaata     4140

gaccttgcca aactaggaga gggttaa                                         4167


<210> 10
<211> 3366
<212> DNA
<213> Streptococcus thermophilus

<400> 10
atgagcgacc tggtgctggg cctggacatc ggcatcggca gcgtgggcgt gggcatcctg       60

aacaaggtga ccggcgagat catccacaag aacagtcgca tcttccctgc tgctcaggct      120

gagaacaacc tggtgcgccg caccaaccgc cagggtcgcc ggcttgctcg ccgcaagaag      180

caccggcgcg tgcgcctgaa ccgcctgttc gaggagagcg gcctgatcac cgacttcacc      240

aagatcagca tcaacctgaa cccctaccag ctgcgcgtga agggcctgac cgacgagctg      300

agcaacgagg agctgttcat cgccctgaag aacatggtga agcaccgcgg catcagctac      360

ctggacgacg ccagcgacga cggcaacagc agcgtgggcg actacgccca gatcgtgaag      420

gagaacagca agcagctgga gaccaagacc cccggccaga tccagctgga gcgctaccag      480

acctacggcc agctgcgcgg cgacttcacc gtggagaagg acggcaagaa gcaccgcctg      540

atcaacgtgt tccccaccag cgcctaccgc agcgaggccc tgcgcatcct gcagacccag      600

caggagttca acccccagat caccgacgag ttcatcaacc gctacctgga gatcctgacc      660

ggcaagcgca agtactacca cggccccggc aacgagaaga gccgcaccga ctacggccgc      720

taccgcacca gcggcgagac cctggacaac atcttcggca tcctgatcgg caagtgcacc      780

ttctaccccg acgagttccg cgccgccaag gccagctaca ccgcccagga gttcaacctg      840

ctgaacgacc tgaacaacct gaccgtgccc accgagacca agaagctgag caaggagcag      900

aagaaccaga tcatcaacta cgtgaagaac gagaaggcca tgggccccgc caagctgttc      960

aagtacatcg ccaagctgct gagctgcgac gtggccgaca tcaagggcta ccgcatcgac     1020

aagagcggca aggccgagat ccacaccttc gaggcctacc gcaagatgaa gaccctggag     1080

accctggaca tcgagcagat ggaccgcgag accctggaca agctggccta cgtgctgacc     1140

ctgaacaccg agcgcgaggg catccaggag gccctggagc acgagttcgc cgacggcagc     1200

ttcagccaga agcaggtgga cgagctggtg cagttccgca aggccaacag cagcatcttc     1260

ggcaagggct ggcacaactt cagcgtgaag ctgatgatgg agctgatccc cgagctgtac     1320

gagaccagcg aggagcagat gaccatcctg acccgcctgg gcaagcagaa gaccaccagc     1380

agcagcaaca agaccaagta catcgacgag aagctgctga ccgaggagat ctacaacccc     1440

gtggtggcca agagcgtgcg ccaggccatc aagatcgtga acgccgccat caaggagtac     1500

ggcgacttcg acaacatcgt gatcgagatg gcccgcgaga ccaacgagga cgacgagaag     1560

aaggccatcc agaagatcca gaaggccaac aaggacgaga aggacgccgc catgctgaag     1620

gccgccaacc agtacaacgg caaggccgag ctgccccaca gcgtgttcca cggccacaag     1680

cagctggcca ccaagatccg cctgtggcac cagcagggcg agcgctgcct gtacaccggc     1740

aagaccatca gcatccacga cctgatcaac aacagcaacc agttcgaggt ggaccacatc     1800

ctgcccctga gcatcacctt cgacgacagc ctggccaaca aggtgctggt gtacgccacc     1860

gccaaccagg agaagggcca gcgcaccccc taccaggccc tggacagcat ggacgacgcc     1920

tggagcttcc gcgagctgaa ggccttcgtg cgcgagagca agaccctgag caacaagaag     1980

aaggagtacc tgctgaccga ggaggacatc agcaagttcg acgtgcgcaa gaagttcatc     2040

gagcgcaacc tggtggacac ccgctacgcc agccgcgtgg tgctgaacgc cctgcaggag     2100

cacttccgcg cccacaagat cgacaccaag gtgagcgtgg tgcgcggcca gttcaccagc     2160

cagctgcgcc gccactgggg catcgagaag acccgcgaca cctaccacca ccacgccgtg     2220

gacgccctga tcattgcggc ttctagccag ctgaacctgt ggaagaagca gaagaacacc     2280

ctggtgagct acagcgagga ccagctgctg gacatcgaga ccggcgagct gatcagcgac     2340

gacgagtaca aggagagcgt gttcaaggcc ccctaccagc acttcgtgga caccctgaag     2400

agcaaggagt tcgaggacag catcctgttc agctaccagg tggacagcaa gttcaaccgc     2460

aagatcagcg acgccaccat ctacgccacc cgccaggcca aggtgggcaa ggacaaggcc     2520

gacgagacct acgtgctggg caagatcaag gacatctaca cccaggacgg ctacgacgcc     2580

ttcatgaaga tctacaagaa ggacaagagc aagttcctga tgtaccgcca cgacccccag     2640

accttcgaga aggtgatcga gcccatcctg gagaactacc ccaacaagca gatcaacgat     2700

aaaggcaagg aggtgccctg caaccccttc ctgaagtaca aggaggagca cggctacatc     2760

cgcaagtaca gcaagaaggg caacggcccc gagatcaaga gcctgaagta ctacgacagc     2820

aagctgggca accacatcga catcaccccc aaggacagca acaacaaggt ggtgctgcag     2880

agcgtgagcc cctggcgcgc cgacgtgtac ttcaacaaga ccaccggcaa gtacgagatc     2940

ctgggcctga agtacgccga cctgcagttt gataagggca ccggcaccta caagatcagc     3000

caggagaagt acaacgacat caagaagaag gagggcgtgg acagcgacag cgagttcaag     3060

ttcaccctgt acaagaacga ccttctgctg gtgaaggaca ccgagaccaa ggagcaacag     3120

ctgttccgct tcctgagccg caccatgccc aagcagaagc actacgtgga gctgaagccc     3180

tacgacaagc agaagttcga gggcggcgag gccctgatca aggtgctggg caacgtggcc     3240

aacagcggcc agtgcaagaa gggcctgggc aagagcaaca tcagcatcta caaggtgcgc     3300

accgacgtgc tgggcaacca gcacatcatc aagaacgagg gcgacaagcc caagctggac     3360

ttctaa                                                                3366


<210> 11
<211> 3366
<212> DNA
<213> Streptococcus thermophilus

<400> 11
atgagcgacc tggtgctggg cctggccatc ggcatcggca gcgtgggcgt gggcatcctg       60

aacaaggtga ccggcgagat catccacaag aacagtcgca tcttccctgc tgctcaggct      120

gagaacaacc tggtgcgccg caccaaccgc cagggtcgcc ggcttgctcg ccgcaagaag      180

caccggcgcg tgcgcctgaa ccgcctgttc gaggagagcg gcctgatcac cgacttcacc      240

aagatcagca tcaacctgaa cccctaccag ctgcgcgtga agggcctgac cgacgagctg      300

agcaacgagg agctgttcat cgccctgaag aacatggtga agcaccgcgg catcagctac      360

ctggacgacg ccagcgacga cggcaacagc agcgtgggcg actacgccca gatcgtgaag      420

gagaacagca agcagctgga gaccaagacc cccggccaga tccagctgga gcgctaccag      480

acctacggcc agctgcgcgg cgacttcacc gtggagaagg acggcaagaa gcaccgcctg      540

atcaacgtgt tccccaccag cgcctaccgc agcgaggccc tgcgcatcct gcagacccag      600

caggagttca acccccagat caccgacgag ttcatcaacc gctacctgga gatcctgacc      660

ggcaagcgca agtactacca cggccccggc aacgagaaga gccgcaccga ctacggccgc      720

taccgcacca gcggcgagac cctggacaac atcttcggca tcctgatcgg caagtgcacc      780

ttctaccccg acgagttccg cgccgccaag gccagctaca ccgcccagga gttcaacctg      840

ctgaacgacc tgaacaacct gaccgtgccc accgagacca agaagctgag caaggagcag      900

aagaaccaga tcatcaacta cgtgaagaac gagaaggcca tgggccccgc caagctgttc      960

aagtacatcg ccaagctgct gagctgcgac gtggccgaca tcaagggcta ccgcatcgac     1020

aagagcggca aggccgagat ccacaccttc gaggcctacc gcaagatgaa gaccctggag     1080

accctggaca tcgagcagat ggaccgcgag accctggaca agctggccta cgtgctgacc     1140

ctgaacaccg agcgcgaggg catccaggag gccctggagc acgagttcgc cgacggcagc     1200

ttcagccaga agcaggtgga cgagctggtg cagttccgca aggccaacag cagcatcttc     1260

ggcaagggct ggcacaactt cagcgtgaag ctgatgatgg agctgatccc cgagctgtac     1320

gagaccagcg aggagcagat gaccatcctg acccgcctgg gcaagcagaa gaccaccagc     1380

agcagcaaca agaccaagta catcgacgag aagctgctga ccgaggagat ctacaacccc     1440

gtggtggcca agagcgtgcg ccaggccatc aagatcgtga acgccgccat caaggagtac     1500

ggcgacttcg acaacatcgt gatcgagatg gcccgcgaga ccaacgagga cgacgagaag     1560

aaggccatcc agaagatcca gaaggccaac aaggacgaga aggacgccgc catgctgaag     1620

gccgccaacc agtacaacgg caaggccgag ctgccccaca gcgtgttcca cggccacaag     1680

cagctggcca ccaagatccg cctgtggcac cagcagggcg agcgctgcct gtacaccggc     1740

aagaccatca gcatccacga cctgatcaac aacagcaacc agttcgaggt ggctgccatc     1800

ctgcccctga gcatcacctt cgacgacagc ctggccaaca aggtgctggt gtacgccacc     1860

gccgctcagg agaagggcca gcgcaccccc taccaggccc tggacagcat ggacgacgcc     1920

tggagcttcc gcgagctgaa ggccttcgtg cgcgagagca agaccctgag caacaagaag     1980

aaggagtacc tgctgaccga ggaggacatc agcaagttcg acgtgcgcaa gaagttcatc     2040

gagcgcaacc tggtggacac ccgctacgcc agccgcgtgg tgctgaacgc cctgcaggag     2100

cacttccgcg cccacaagat cgacaccaag gtgagcgtgg tgcgcggcca gttcaccagc     2160

cagctgcgcc gccactgggg catcgagaag acccgcgaca cctaccacca ccacgccgtg     2220

gacgccctga tcattgcggc ttctagccag ctgaacctgt ggaagaagca gaagaacacc     2280

ctggtgagct acagcgagga ccagctgctg gacatcgaga ccggcgagct gatcagcgac     2340

gacgagtaca aggagagcgt gttcaaggcc ccctaccagc acttcgtgga caccctgaag     2400

agcaaggagt tcgaggacag catcctgttc agctaccagg tggacagcaa gttcaaccgc     2460

aagatcagcg acgccaccat ctacgccacc cgccaggcca aggtgggcaa ggacaaggcc     2520

gacgagacct acgtgctggg caagatcaag gacatctaca cccaggacgg ctacgacgcc     2580

ttcatgaaga tctacaagaa ggacaagagc aagttcctga tgtaccgcca cgacccccag     2640

accttcgaga aggtgatcga gcccatcctg gagaactacc ccaacaagca gatcaacgat     2700

aaaggcaagg aggtgccctg caaccccttc ctgaagtaca aggaggagca cggctacatc     2760

cgcaagtaca gcaagaaggg caacggcccc gagatcaaga gcctgaagta ctacgacagc     2820

aagctgggca accacatcga catcaccccc aaggacagca acaacaaggt ggtgctgcag     2880

agcgtgagcc cctggcgcgc cgacgtgtac ttcaacaaga ccaccggcaa gtacgagatc     2940

ctgggcctga agtacgccga cctgcagttt gataagggca ccggcaccta caagatcagc     3000

caggagaagt acaacgacat caagaagaag gagggcgtgg acagcgacag cgagttcaag     3060

ttcaccctgt acaagaacga ccttctgctg gtgaaggaca ccgagaccaa ggagcaacag     3120

ctgttccgct tcctgagccg caccatgccc aagcagaagc actacgtgga gctgaagccc     3180

tacgacaagc agaagttcga gggcggcgag gccctgatca aggtgctggg caacgtggcc     3240

aacagcggcc agtgcaagaa gggcctgggc aagagcaaca tcagcatcta caaggtgcgc     3300

accgacgtgc tgggcaacca gcacatcatc aagaacgagg gcgacaagcc caagctggac     3360

ttctaa                                                                3366


<210> 12
<211> 3399
<212> DNA
<213> Streptococcus thermophilus

<400> 12
atgagcgacc tggtgctggg cctggacatc ggcatcggca gcgtgggcgt gggcatcctg       60

aacaaggtga ccggcgagat catccacaag aacagtcgca tcttccctgc tgctcaggct      120

gagaacaacc tggtgcgccg caccaaccgc cagggtcgcc ggcttgctcg ccgcaagaag      180

caccggcgcg tgcgcctgaa ccgcctgttc gaggagagcg gcctgatcac cgacttcacc      240

aagatcagca tcaacctgaa cccctaccag ctgcgcgtga agggcctgac cgacgagctg      300

agcaacgagg agctgttcat cgccctgaag aacatggtga agcaccgcgg catcagctac      360

ctggacgacg ccagcgacga cggcaacagc agcgtgggcg actacgccca gatcgtgaag      420

gagaacagca agcagctgga gaccaagacc cccggccaga tccagctgga gcgctaccag      480

acctacggcc agctgcgcgg cgacttcacc gtggagaagg acggcaagaa gcaccgcctg      540

atcaacgtgt tccccaccag cgcctaccgc agcgaggccc tgcgcatcct gcagacccag      600

caggagttca acccccagat caccgacgag ttcatcaacc gctacctgga gatcctgacc      660

ggcaagcgca agtactacca cggccccggc aacgagaaga gccgcaccga ctacggccgc      720

taccgcacca gcggcgagac cctggacaac atcttcggca tcctgatcgg caagtgcacc      780

ttctaccccg acgagttccg cgccgccaag gccagctaca ccgcccagga gttcaacctg      840

ctgaacgacc tgaacaacct gaccgtgccc accgagacca agaagctgag caaggagcag      900

aagaaccaga tcatcaacta cgtgaagaac gagaaggcca tgggccccgc caagctgttc      960

aagtacatcg ccaagctgct gagctgcgac gtggccgaca tcaagggcta ccgcatcgac     1020

aagagcggca aggccgagat ccacaccttc gaggcctacc gcaagatgaa gaccctggag     1080

accctggaca tcgagcagat ggaccgcgag accctggaca agctggccta cgtgctgacc     1140

ctgaacaccg agcgcgaggg catccaggag gccctggagc acgagttcgc cgacggcagc     1200

ttcagccaga agcaggtgga cgagctggtg cagttccgca aggccaacag cagcatcttc     1260

ggcaagggct ggcacaactt cagcgtgaag ctgatgatgg agctgatccc cgagctgtac     1320

gagaccagcg aggagcagat gaccatcctg acccgcctgg gcaagcagaa gaccaccagc     1380

agcagcaaca agaccaagta catcgacgag aagctgctga ccgaggagat ctacaacccc     1440

gtggtggcca agagcgtgcg ccaggccatc aagatcgtga acgccgccat caaggagtac     1500

ggcgacttcg acaacatcgt gatcgagatg gcccgcgaga ccaacgagga cgacgagaag     1560

aaggccatcc agaagatcca gaaggccaac aaggacgaga aggacgccgc catgctgaag     1620

gccgccaacc agtacaacgg caaggccgag ctgccccaca gcgtgttcca cggccacaag     1680

cagctggcca ccaagatccg cctgtggcac cagcagggcg agcgctgcct gtacaccggc     1740

aagaccatca gcatccacga cctgatcaac aacagcaacc agttcgaggt ggaccacatc     1800

ctgcccctga gcatcacctt cgacgacagc ctggccaaca aggtgctggt gtacgccacc     1860

gccaaccagg agaagggcca gcgcaccccc taccaggccc tggacagcat ggacgacgcc     1920

tggagcttcc gcgagctgaa ggccttcgtg cgcgagagca agaccctgag caacaagaag     1980

aaggagtacc tgctgaccga ggaggacatc agcaagttcg acgtgcgcaa gaagttcatc     2040

gagcgcaacc tggtggacac ccgctacgcc agccgcgtgg tgctgaacgc cctgcaggag     2100

cacttccgcg cccacaagat cgacaccaag gtgagcgtgg tgcgcggcca gttcaccagc     2160

cagctgcgcc gccactgggg catcgagaag acccgcgaca cctaccacca ccacgccgtg     2220

gacgccctga tcattgcggc ttctagccag ctgaacctgt ggaagaagca gaagaacacc     2280

ctggtgagct acagcgagga ccagctgctg gacatcgaga ccggcgagct gatcagcgac     2340

gacgagtaca aggagagcgt gttcaaggcc ccctaccagc acttcgtgga caccctgaag     2400

agcaaggagt tcgaggacag catcctgttc agctaccagg tggacagcaa gttcaaccgc     2460

aagatcagcg acgccaccat ctacgccacc cgccaggcca aggtgggcaa ggacaaggcc     2520

gacgagacct acgtgctggg caagatcaag gacatctaca cccaggacgg ctacgacgcc     2580

ttcatgaaga tctacaagaa ggacaagagc aagttcctga tgtaccgcca cgacccccag     2640

accttcgaga aggtgatcga gcccatcctg gagaactacc ccaacaagca gatcaacgat     2700

aaaggcaagg aggtgccctg caaccccttc ctgaagtaca aggaggagca cggctacatc     2760

cgcaagtaca gcaagaaggg caacggcccc gagatcaaga gcctgaagta ctacgacagc     2820

aagctgggca accacatcga catcaccccc aaggacagca acaacaaggt ggtgctgcag     2880

agcgtgagcc cctggcgcgc cgacgtgtac ttcaacaaga ccaccggcaa gtacgagatc     2940

ctgggcctga agtacgccga cctgcagttt gataagggca ccggcaccta caagatcagc     3000

caggagaagt acaacgacat caagaagaag gagggcgtgg acagcgacag cgagttcaag     3060

ttcaccctgt acaagaacga ccttctgctg gtgaaggaca ccgagaccaa ggagcaacag     3120

ctgttccgct tcctgagccg caccatgccc aagcagaagc actacgtgga gctgaagccc     3180

tacgacaagc agaagttcga gggcggcgag gccctgatca aggtgctggg caacgtggcc     3240

aacagcggcc agtgcaagaa gggcctgggc aagagcaaca tcagcatcta caaggtgcgc     3300

accgacgtgc tgggcaacca gcacatcatc aagaacgagg gcgacaagcc caagctggac     3360

ttcagcaggg ctgaccccaa gaagaagagg aaggtgtga                            3399


<210> 13
<211> 3459
<212> DNA
<213> Streptococcus thermophilus

<400> 13
atgagcgacc tggtgctggg cctggacatc ggcatcggca gcgtgggcgt gggcatcctg       60

aacaaggtga ccggcgagat catccacaag aacagtcgca tcttccctgc tgctcaggct      120

gagaacaacc tggtgcgccg caccaaccgc cagggtcgcc ggcttgctcg ccgcaagaag      180

caccggcgcg tgcgcctgaa ccgcctgttc gaggagagcg gcctgatcac cgacttcacc      240

aagatcagca tcaacctgaa cccctaccag ctgcgcgtga agggcctgac cgacgagctg      300

agcaacgagg agctgttcat cgccctgaag aacatggtga agcaccgcgg catcagctac      360

ctggacgacg ccagcgacga cggcaacagc agcgtgggcg actacgccca gatcgtgaag      420

gagaacagca agcagctgga gaccaagacc cccggccaga tccagctgga gcgctaccag      480

acctacggcc agctgcgcgg cgacttcacc gtggagaagg acggcaagaa gcaccgcctg      540

atcaacgtgt tccccaccag cgcctaccgc agcgaggccc tgcgcatcct gcagacccag      600

caggagttca acccccagat caccgacgag ttcatcaacc gctacctgga gatcctgacc      660

ggcaagcgca agtactacca cggccccggc aacgagaaga gccgcaccga ctacggccgc      720

taccgcacca gcggcgagac cctggacaac atcttcggca tcctgatcgg caagtgcacc      780

ttctaccccg acgagttccg cgccgccaag gccagctaca ccgcccagga gttcaacctg      840

ctgaacgacc tgaacaacct gaccgtgccc accgagacca agaagctgag caaggagcag      900

aagaaccaga tcatcaacta cgtgaagaac gagaaggcca tgggccccgc caagctgttc      960

aagtacatcg ccaagctgct gagctgcgac gtggccgaca tcaagggcta ccgcatcgac     1020

aagagcggca aggccgagat ccacaccttc gaggcctacc gcaagatgaa gaccctggag     1080

accctggaca tcgagcagat ggaccgcgag accctggaca agctggccta cgtgctgacc     1140

ctgaacaccg agcgcgaggg catccaggag gccctggagc acgagttcgc cgacggcagc     1200

ttcagccaga agcaggtgga cgagctggtg cagttccgca aggccaacag cagcatcttc     1260

ggcaagggct ggcacaactt cagcgtgaag ctgatgatgg agctgatccc cgagctgtac     1320

gagaccagcg aggagcagat gaccatcctg acccgcctgg gcaagcagaa gaccaccagc     1380

agcagcaaca agaccaagta catcgacgag aagctgctga ccgaggagat ctacaacccc     1440

gtggtggcca agagcgtgcg ccaggccatc aagatcgtga acgccgccat caaggagtac     1500

ggcgacttcg acaacatcgt gatcgagatg gcccgcgaga ccaacgagga cgacgagaag     1560

aaggccatcc agaagatcca gaaggccaac aaggacgaga aggacgccgc catgctgaag     1620

gccgccaacc agtacaacgg caaggccgag ctgccccaca gcgtgttcca cggccacaag     1680

cagctggcca ccaagatccg cctgtggcac cagcagggcg agcgctgcct gtacaccggc     1740

aagaccatca gcatccacga cctgatcaac aacagcaacc agttcgaggt ggaccacatc     1800

ctgcccctga gcatcacctt cgacgacagc ctggccaaca aggtgctggt gtacgccacc     1860

gccaaccagg agaagggcca gcgcaccccc taccaggccc tggacagcat ggacgacgcc     1920

tggagcttcc gcgagctgaa ggccttcgtg cgcgagagca agaccctgag caacaagaag     1980

aaggagtacc tgctgaccga ggaggacatc agcaagttcg acgtgcgcaa gaagttcatc     2040

gagcgcaacc tggtggacac ccgctacgcc agccgcgtgg tgctgaacgc cctgcaggag     2100

cacttccgcg cccacaagat cgacaccaag gtgagcgtgg tgcgcggcca gttcaccagc     2160

cagctgcgcc gccactgggg catcgagaag acccgcgaca cctaccacca ccacgccgtg     2220

gacgccctga tcattgcggc ttctagccag ctgaacctgt ggaagaagca gaagaacacc     2280

ctggtgagct acagcgagga ccagctgctg gacatcgaga ccggcgagct gatcagcgac     2340

gacgagtaca aggagagcgt gttcaaggcc ccctaccagc acttcgtgga caccctgaag     2400

agcaaggagt tcgaggacag catcctgttc agctaccagg tggacagcaa gttcaaccgc     2460

aagatcagcg acgccaccat ctacgccacc cgccaggcca aggtgggcaa ggacaaggcc     2520

gacgagacct acgtgctggg caagatcaag gacatctaca cccaggacgg ctacgacgcc     2580

ttcatgaaga tctacaagaa ggacaagagc aagttcctga tgtaccgcca cgacccccag     2640

accttcgaga aggtgatcga gcccatcctg gagaactacc ccaacaagca gatcaacgat     2700

aaaggcaagg aggtgccctg caaccccttc ctgaagtaca aggaggagca cggctacatc     2760

cgcaagtaca gcaagaaggg caacggcccc gagatcaaga gcctgaagta ctacgacagc     2820

aagctgggca accacatcga catcaccccc aaggacagca acaacaaggt ggtgctgcag     2880

agcgtgagcc cctggcgcgc cgacgtgtac ttcaacaaga ccaccggcaa gtacgagatc     2940

ctgggcctga agtacgccga cctgcagttt gataagggca ccggcaccta caagatcagc     3000

caggagaagt acaacgacat caagaagaag gagggcgtgg acagcgacag cgagttcaag     3060

ttcaccctgt acaagaacga ccttctgctg gtgaaggaca ccgagaccaa ggagcaacag     3120

ctgttccgct tcctgagccg caccatgccc aagcagaagc actacgtgga gctgaagccc     3180

tacgacaagc agaagttcga gggcggcgag gccctgatca aggtgctggg caacgtggcc     3240

aacagcggcc agtgcaagaa gggcctgggc aagagcaaca tcagcatcta caaggtgcgc     3300

accgacgtgc tgggcaacca gcacatcatc aagaacgagg gcgacaagcc caagctggac     3360

ttcgcggccg cagatccaaa aaagaagaga aaggtagatc caaaaaagaa gagaaaggta     3420

gatccaaaaa agaagagaaa ggtagatacg gccgcatag                            3459


<210> 14
<211> 3585
<212> DNA
<213> Streptococcus thermophilus

<400> 14
atgagcgacc tggtgctggg cctggccatc ggcatcggca gcgtgggcgt gggcatcctg       60

aacaaggtga ccggcgagat catccacaag aacagtcgca tcttccctgc tgctcaggct      120

gagaacaacc tggtgcgccg caccaaccgc cagggtcgcc ggcttgctcg ccgcaagaag      180

caccggcgcg tgcgcctgaa ccgcctgttc gaggagagcg gcctgatcac cgacttcacc      240

aagatcagca tcaacctgaa cccctaccag ctgcgcgtga agggcctgac cgacgagctg      300

agcaacgagg agctgttcat cgccctgaag aacatggtga agcaccgcgg catcagctac      360

ctggacgacg ccagcgacga cggcaacagc agcgtgggcg actacgccca gatcgtgaag      420

gagaacagca agcagctgga gaccaagacc cccggccaga tccagctgga gcgctaccag      480

acctacggcc agctgcgcgg cgacttcacc gtggagaagg acggcaagaa gcaccgcctg      540

atcaacgtgt tccccaccag cgcctaccgc agcgaggccc tgcgcatcct gcagacccag      600

caggagttca acccccagat caccgacgag ttcatcaacc gctacctgga gatcctgacc      660

ggcaagcgca agtactacca cggccccggc aacgagaaga gccgcaccga ctacggccgc      720

taccgcacca gcggcgagac cctggacaac atcttcggca tcctgatcgg caagtgcacc      780

ttctaccccg acgagttccg cgccgccaag gccagctaca ccgcccagga gttcaacctg      840

ctgaacgacc tgaacaacct gaccgtgccc accgagacca agaagctgag caaggagcag      900

aagaaccaga tcatcaacta cgtgaagaac gagaaggcca tgggccccgc caagctgttc      960

aagtacatcg ccaagctgct gagctgcgac gtggccgaca tcaagggcta ccgcatcgac     1020

aagagcggca aggccgagat ccacaccttc gaggcctacc gcaagatgaa gaccctggag     1080

accctggaca tcgagcagat ggaccgcgag accctggaca agctggccta cgtgctgacc     1140

ctgaacaccg agcgcgaggg catccaggag gccctggagc acgagttcgc cgacggcagc     1200

ttcagccaga agcaggtgga cgagctggtg cagttccgca aggccaacag cagcatcttc     1260

ggcaagggct ggcacaactt cagcgtgaag ctgatgatgg agctgatccc cgagctgtac     1320

gagaccagcg aggagcagat gaccatcctg acccgcctgg gcaagcagaa gaccaccagc     1380

agcagcaaca agaccaagta catcgacgag aagctgctga ccgaggagat ctacaacccc     1440

gtggtggcca agagcgtgcg ccaggccatc aagatcgtga acgccgccat caaggagtac     1500

ggcgacttcg acaacatcgt gatcgagatg gcccgcgaga ccaacgagga cgacgagaag     1560

aaggccatcc agaagatcca gaaggccaac aaggacgaga aggacgccgc catgctgaag     1620

gccgccaacc agtacaacgg caaggccgag ctgccccaca gcgtgttcca cggccacaag     1680

cagctggcca ccaagatccg cctgtggcac cagcagggcg agcgctgcct gtacaccggc     1740

aagaccatca gcatccacga cctgatcaac aacagcaacc agttcgaggt ggctgccatc     1800

ctgcccctga gcatcacctt cgacgacagc ctggccaaca aggtgctggt gtacgccacc     1860

gccgctcagg agaagggcca gcgcaccccc taccaggccc tggacagcat ggacgacgcc     1920

tggagcttcc gcgagctgaa ggccttcgtg cgcgagagca agaccctgag caacaagaag     1980

aaggagtacc tgctgaccga ggaggacatc agcaagttcg acgtgcgcaa gaagttcatc     2040

gagcgcaacc tggtggacac ccgctacgcc agccgcgtgg tgctgaacgc cctgcaggag     2100

cacttccgcg cccacaagat cgacaccaag gtgagcgtgg tgcgcggcca gttcaccagc     2160

cagctgcgcc gccactgggg catcgagaag acccgcgaca cctaccacca ccacgccgtg     2220

gacgccctga tcattgcggc ttctagccag ctgaacctgt ggaagaagca gaagaacacc     2280

ctggtgagct acagcgagga ccagctgctg gacatcgaga ccggcgagct gatcagcgac     2340

gacgagtaca aggagagcgt gttcaaggcc ccctaccagc acttcgtgga caccctgaag     2400

agcaaggagt tcgaggacag catcctgttc agctaccagg tggacagcaa gttcaaccgc     2460

aagatcagcg acgccaccat ctacgccacc cgccaggcca aggtgggcaa ggacaaggcc     2520

gacgagacct acgtgctggg caagatcaag gacatctaca cccaggacgg ctacgacgcc     2580

ttcatgaaga tctacaagaa ggacaagagc aagttcctga tgtaccgcca cgacccccag     2640

accttcgaga aggtgatcga gcccatcctg gagaactacc ccaacaagca gatcaacgat     2700

aaaggcaagg aggtgccctg caaccccttc ctgaagtaca aggaggagca cggctacatc     2760

cgcaagtaca gcaagaaggg caacggcccc gagatcaaga gcctgaagta ctacgacagc     2820

aagctgggca accacatcga catcaccccc aaggacagca acaacaaggt ggtgctgcag     2880

agcgtgagcc cctggcgcgc cgacgtgtac ttcaacaaga ccaccggcaa gtacgagatc     2940

ctgggcctga agtacgccga cctgcagttt gataagggca ccggcaccta caagatcagc     3000

caggagaagt acaacgacat caagaagaag gagggcgtgg acagcgacag cgagttcaag     3060

ttcaccctgt acaagaacga ccttctgctg gtgaaggaca ccgagaccaa ggagcaacag     3120

ctgttccgct tcctgagccg caccatgccc aagcagaagc actacgtgga gctgaagccc     3180

tacgacaagc agaagttcga gggcggcgag gccctgatca aggtgctggg caacgtggcc     3240

aacagcggcc agtgcaagaa gggcctgggc aagagcaaca tcagcatcta caaggtgcgc     3300

accgacgtgc tgggcaacca gcacatcatc aagaacgagg gcgacaagcc caagctggac     3360

ttcagcaggg ctgaccccaa gaagaagagg aaggtggagg ccagcggttc cggacgggct     3420

gacgcattgg acgattttga tctggatatg ctgggaagtg acgccctcga tgattttgac     3480

cttgacatgc ttggttcgga tgcccttgat gactttgacc tcgacatgct cggcagtgac     3540

gcccttgatg atttcgacct ggacatgctg attaactcta gatga                     3585


<210> 15
<211> 3606
<212> DNA
<213> Streptococcus thermophilus

<400> 15
atgcccaaga agaagaggaa ggtgagcgac ctggtgctgg gcctggccat cggcatcggc       60

agcgtgggcg tgggcatcct gaacaaggtg accggcgaga tcatccacaa gaacagtcgc      120

atcttccctg ctgctcaggc tgagaacaac ctggtgcgcc gcaccaaccg ccagggtcgc      180

cggcttgctc gccgcaagaa gcaccggcgc gtgcgcctga accgcctgtt cgaggagagc      240

ggcctgatca ccgacttcac caagatcagc atcaacctga acccctacca gctgcgcgtg      300

aagggcctga ccgacgagct gagcaacgag gagctgttca tcgccctgaa gaacatggtg      360

aagcaccgcg gcatcagcta cctggacgac gccagcgacg acggcaacag cagcgtgggc      420

gactacgccc agatcgtgaa ggagaacagc aagcagctgg agaccaagac ccccggccag      480

atccagctgg agcgctacca gacctacggc cagctgcgcg gcgacttcac cgtggagaag      540

gacggcaaga agcaccgcct gatcaacgtg ttccccacca gcgcctaccg cagcgaggcc      600

ctgcgcatcc tgcagaccca gcaggagttc aacccccaga tcaccgacga gttcatcaac      660

cgctacctgg agatcctgac cggcaagcgc aagtactacc acggccccgg caacgagaag      720

agccgcaccg actacggccg ctaccgcacc agcggcgaga ccctggacaa catcttcggc      780

atcctgatcg gcaagtgcac cttctacccc gacgagttcc gcgccgccaa ggccagctac      840

accgcccagg agttcaacct gctgaacgac ctgaacaacc tgaccgtgcc caccgagacc      900

aagaagctga gcaaggagca gaagaaccag atcatcaact acgtgaagaa cgagaaggcc      960

atgggccccg ccaagctgtt caagtacatc gccaagctgc tgagctgcga cgtggccgac     1020

atcaagggct accgcatcga caagagcggc aaggccgaga tccacacctt cgaggcctac     1080

cgcaagatga agaccctgga gaccctggac atcgagcaga tggaccgcga gaccctggac     1140

aagctggcct acgtgctgac cctgaacacc gagcgcgagg gcatccagga ggccctggag     1200

cacgagttcg ccgacggcag cttcagccag aagcaggtgg acgagctggt gcagttccgc     1260

aaggccaaca gcagcatctt cggcaagggc tggcacaact tcagcgtgaa gctgatgatg     1320

gagctgatcc ccgagctgta cgagaccagc gaggagcaga tgaccatcct gacccgcctg     1380

ggcaagcaga agaccaccag cagcagcaac aagaccaagt acatcgacga gaagctgctg     1440

accgaggaga tctacaaccc cgtggtggcc aagagcgtgc gccaggccat caagatcgtg     1500

aacgccgcca tcaaggagta cggcgacttc gacaacatcg tgatcgagat ggcccgcgag     1560

accaacgagg acgacgagaa gaaggccatc cagaagatcc agaaggccaa caaggacgag     1620

aaggacgccg ccatgctgaa ggccgccaac cagtacaacg gcaaggccga gctgccccac     1680

agcgtgttcc acggccacaa gcagctggcc accaagatcc gcctgtggca ccagcagggc     1740

gagcgctgcc tgtacaccgg caagaccatc agcatccacg acctgatcaa caacagcaac     1800

cagttcgagg tggctgccat cctgcccctg agcatcacct tcgacgacag cctggccaac     1860

aaggtgctgg tgtacgccac cgccgctcag gagaagggcc agcgcacccc ctaccaggcc     1920

ctggacagca tggacgacgc ctggagcttc cgcgagctga aggccttcgt gcgcgagagc     1980

aagaccctga gcaacaagaa gaaggagtac ctgctgaccg aggaggacat cagcaagttc     2040

gacgtgcgca agaagttcat cgagcgcaac ctggtggaca cccgctacgc cagccgcgtg     2100

gtgctgaacg ccctgcagga gcacttccgc gcccacaaga tcgacaccaa ggtgagcgtg     2160

gtgcgcggcc agttcaccag ccagctgcgc cgccactggg gcatcgagaa gacccgcgac     2220

acctaccacc accacgccgt ggacgccctg atcattgcgg cttctagcca gctgaacctg     2280

tggaagaagc agaagaacac cctggtgagc tacagcgagg accagctgct ggacatcgag     2340

accggcgagc tgatcagcga cgacgagtac aaggagagcg tgttcaaggc cccctaccag     2400

cacttcgtgg acaccctgaa gagcaaggag ttcgaggaca gcatcctgtt cagctaccag     2460

gtggacagca agttcaaccg caagatcagc gacgccacca tctacgccac ccgccaggcc     2520

aaggtgggca aggacaaggc cgacgagacc tacgtgctgg gcaagatcaa ggacatctac     2580

acccaggacg gctacgacgc cttcatgaag atctacaaga aggacaagag caagttcctg     2640

atgtaccgcc acgaccccca gaccttcgag aaggtgatcg agcccatcct ggagaactac     2700

cccaacaagc agatcaacga taaaggcaag gaggtgccct gcaacccctt cctgaagtac     2760

aaggaggagc acggctacat ccgcaagtac agcaagaagg gcaacggccc cgagatcaag     2820

agcctgaagt actacgacag caagctgggc aaccacatcg acatcacccc caaggacagc     2880

aacaacaagg tggtgctgca gagcgtgagc ccctggcgcg ccgacgtgta cttcaacaag     2940

accaccggca agtacgagat cctgggcctg aagtacgccg acctgcagtt tgataagggc     3000

accggcacct acaagatcag ccaggagaag tacaacgaca tcaagaagaa ggagggcgtg     3060

gacagcgaca gcgagttcaa gttcaccctg tacaagaacg accttctgct ggtgaaggac     3120

accgagacca aggagcaaca gctgttccgc ttcctgagcc gcaccatgcc caagcagaag     3180

cactacgtgg agctgaagcc ctacgacaag cagaagttcg agggcggcga ggccctgatc     3240

aaggtgctgg gcaacgtggc caacagcggc cagtgcaaga agggcctggg caagagcaac     3300

atcagcatct acaaggtgcg caccgacgtg ctgggcaacc agcacatcat caagaacgag     3360

ggcgacaagc ccaagctgga cttcagcagg gctgacccca agaagaagag gaaggtggag     3420

gccagcggtt ccggacgggc tgacgcattg gacgattttg atctggatat gctgggaagt     3480

gacgccctcg atgattttga ccttgacatg cttggttcgg atgcccttga tgactttgac     3540

ctcgacatgc tcggcagtga cgcccttgat gatttcgacc tggacatgct gattaactct     3600

agatga                                                                3606


<210> 16
<211> 3366
<212> DNA
<213> Streptococcus thermophilus

<400> 16
atgagtgact tagttttagg acttgatatc ggtataggtt ctgttggtgt aggtatcctt       60

aacaaagtga caggagaaat tatccataaa aactcacgca tcttcccagc agctcaagcg      120

gaaaataacc tagtacgtag aacgaatcgt caaggaagac gcttgacacg acgtaaaaaa      180

catcgtagag ttcgtttaaa tcgtctattt gaggaaagtg gattaatcac cgattttacg      240

aagatttcaa ttaatcttaa cccatatcaa ttacgagtta agggcttgac cgatgaattg      300

tctaatgaag aactgtttat cgctcttaaa aatatggtga aacaccgtgg gattagttac      360

ctcgatgatg ctagtgatga cggaaattca tcaataggag actatgcaca aattgttaag      420

gaaaatagta aacaattaga aactaagaca ccgggacaga tacagttgga acgctaccaa      480

acatatggtc aattacgtgg tgattttact gttgagaaag atggcaaaaa acatcgcttg      540

attaatgtct ttccaacatc agcttatcgt tcagaagcct taaggatact gcaaactcaa      600

caagaattta atccacagat tacagatgaa tttattaatc gttatctcga aattttaact      660

ggaaaacgga aatattatca tggacccgga aatgaaaagt cacggactga ttatggtcgt      720

tacagaacga gtggagaaac tttagacaat atttttggaa ttctaattgg gaaatgtaca      780

ttttatccag acgagtttag agcagcaaaa gcttcctaca cggctcaaga attcaatttg      840

ctaaatgatt tgaacaatct aacagttcct actgaaacca aaaagttgag caaagaacag      900

aagaatcaaa tcattaatta tgtcaaaaat gaaaaggcaa tggggccagc gaaacttttt      960

aaatatatcg ctaagttact ttcttgtgat gttgcagata tcaagggata ccgtatcgac     1020

aaatcaggta aggctgagat tcatactttc gaagcctatc gaaaaatgaa aacgcttgaa     1080

accttagata ttgagcaaat ggatagagaa acgcttgata aattagccta tgtcttaaca     1140

ttaaacactg agagggaagg tattcaagaa gccttagaac atgaatttgc tgatggtagc     1200

tttagccaga agcaagttga cgaattggtt caattccgca aagcaaatag ttccattttt     1260

ggaaaaggat ggcataattt ttctgtcaaa ctgatgatgg agttaattcc agaattgtat     1320

gagacgtcag aagagcaaat gactatccta acacgacttg gaaaacaaaa aacgacttcg     1380

tcttcaaata aaacaaaata tatagatgaa aaactattaa ctgaagaaat ctataatcct     1440

gttgttgcta agtctgttcg ccaggctata aaaatcgtaa atgcggcgat taaagaatac     1500

ggagactttg acaatattgt catcgaaatg gctcgtgaaa caaatgaaga tgatgaaaag     1560

aaagctattc aaaagattca aaaagccaac aaagatgaaa aagatgcagc aatgcttaag     1620

gctgctaacc aatataatgg aaaggctgaa ttaccacata gtgttttcca cggtcataag     1680

caattagcga ctaaaatccg cctttggcat cagcaaggag aacgttgcct ttatactggt     1740

aagacaatct caatccatga tttgataaat aattctaatc agtttgaagt agatcatatt     1800

ttacctcttt ctatcacatt cgatgatagc cttgcaaata aggttttggt ttatgcaact     1860

gctaaccaag aaaaaggaca acgaacacct tatcaggctt tagatagtat ggatgatgcg     1920

tggtctttcc gtgaattaaa agcttttgta cgtgagtcaa aaacactttc gaacaagaaa     1980

aaagaatacc tccttacaga agaagatatt tcaaagtttg atgttcgaaa gaaatttatt     2040

gaacgaaatc ttgtagatac aagatacgct tcaagagttg tcctcaatgc ccttcaagaa     2100

cactttagag ctcacaagat tgatacaaaa gtttccgtgg ttcgtggcca atttacatct     2160

caattgagac gccattgggg aattgagaag actcgtgata cttatcatca ccatgctgtc     2220

gatgcattga ttattgccgc ctcaagtcag ttgaatttgt ggaaaaaaca aaagaatacc     2280

cttgtaagtt attcagaaga ccaactcctt gatattgaaa caggtgaact tattagtgat     2340

gatgagtaca aggaatctgt gttcaaagcc ccttatcaac attttgttga tacattgaag     2400

agtaaagaat ttgaagacag tatcttattc tcttatcaag tggattctaa gtttaatcgt     2460

aaaatatcag atgccactat ttatgcgaca agacaggcta aagtaggaaa agataaggcg     2520

gatgaaactt atgtcttagg gaaaatcaaa gatatttata ctcaggatgg ttatgatgcc     2580

tttatgaaga tttataagaa ggataagtca aaattcctca tgtatcgtca cgacccacaa     2640

acctttgaga aagttatcga gccaatttta gagaactatc ctaataagca aataaatgaa     2700

aaagggaaag aggtaccatg taatcctttc ctaaaatata aagaagaaca tggctatatt     2760

cgtaaatata gtaaaaaagg caatggtcct gaaatcaaga gtcttaaata ctatgatagt     2820

aagctaggca atcatattga tattactccg aaggatagta acaataaagt tgtcttacag     2880

tcagtttctc catggagagc ggatgtctat ttcaataaga ctactggaaa atacgaaatc     2940

ctcggattga aatatgctga tttacaattt gaaaaaggga caggaacata taagatttcc     3000

caggaaaaat acaatgacat taagaaaaaa gagggtgtag attctgattc agaattcaag     3060

tttacacttt ataaaaatga tttgttactc gttaaagata cagaaacaaa agaacaacag     3120

cttttccgtt ttctttctcg aactatgcct aaacaaaagc attatgttga attaaaacct     3180

tatgataaac agaaatttga aggaggtgag gcgttaatta aagtgttggg taacgttgct     3240

aatagtggtc aatgcaaaaa agggctagga aaatcaaata tttctattta taaggtaaga     3300

acagatgtcc taggaaatca gcatatcatc aaaaatgagg gtgataagcc taagctagat     3360

ttttaa                                                                3366


<210> 17
<211> 4167
<212> DNA
<213> Streptococcus thermophilus

<400> 17
atgactaagc catactcaat tggacttgat attggaacga atagtgttgg atgggctgta       60

ataactgata attacaaggt tccgtctaaa aaaatgaaag tcttaggaaa tacgagtaaa      120

aagtatatca aaaagaacct gttaggtgta ttactctttg actctggaat cacagcagaa      180

ggaagaagat tgaagcgtac tgcaagaaga cgttatacta gacgccgtaa tcgtatcctt      240

tatttgcagg aaatttttag cacggagatg gctacattag atgatgcttt ctttcaaaga      300

cttgacgatt cgtttttagt tcctgatgat aaacgtgata gtaagtatcc gatatttgga      360

aacttagtag aagaaaaagt ctatcatgat gaatttccaa ctatctatca tttaaggaaa      420

tatttagcag atagtactaa aaaagcagat ttgcgtctag tttatcttgc attggctcat      480

atgattaaat atagaggtca cttcttaatt gaaggagagt ttaattcaaa aaataatgat      540

attcagaaga attttcaaga ctttttggac acttataatg ctatttttga atcggattta      600

tcacttgaga atagtaaaca acttgaggaa attgttaaag ataagattag taaattagaa      660

aagaaagatc gtattttaaa actcttccct ggggagaaga attcggggat tttttcagag      720

tttctaaagt tgattgtagg aaatcaagct gattttagga aatgttttaa tttagacgaa      780

aaagcctcct tacatttttc caaagaaagc tatgatgaag atttagagac tttgttaggt      840

tatattggag atgattacag tgatgtcttt ctcaaagcaa agaaacttta tgatgctatt      900

cttttatcgg gttttctgac tgtaactgat aatgagacag aagcacctct ctcttctgct      960

atgataaagc gatataatga acacaaagaa gatttagcgt tactaaagga atatataaga     1020

aatatttcac taaaaacgta taatgaagta tttaaagatg acaccaaaaa tggttatgct     1080

ggttatattg atggaaaaac aaatcaggaa gatttctacg tatatctaaa aaacctattg     1140

gctgaatttg aaggtgcgga ttattttctt gaaaaaattg atcgagaaga ttttttgaga     1200

aagcaacgta catttgacaa tggttcgata ccatatcaga ttcatcttca agaaatgaga     1260

gcaattcttg ataagcaagc taaattttat cctttcttgg ctaaaaataa agaaagaatc     1320

gagaagattt taaccttccg aattccttat tatgtaggtc cacttgcgag agggaatagt     1380

gattttgcct ggtcaataag aaaacgaaat gaaaaaatta caccttggaa ttttgaggac     1440

gttattgaca aagaatcttc ggcagaggct ttcattaatc gaatgactag ttttgatttg     1500

tatttgccag aagagaaggt acttccaaag catagtctct tatacgaaac ttttaatgta     1560

tataatgaat taacaaaagt tagatttatt gccgaaagta tgagagatta tcaattttta     1620

gatagtaagc agaagaaaga tattgttaga ctttatttta aagataaaag gaaagttact     1680

gataaggata ttattgaata tttacatgca atttatgggt atgatggaat tgaattaaaa     1740

ggcatagaga aacagtttaa ttctagttta tctacttatc acgatctttt aaatattatt     1800

aatgataaag agtttttgga tgatagttca aatgaagcga ttatcgaaga aattatccat     1860

actttgacaa tttttgaaga tagagagatg ataaaacaac gtctttcaaa atttgagaat     1920

atattcgata aatccgtttt gaaaaagtta tctcgtagac attacactgg ctggggtaag     1980

ttatctgcta agcttattaa tggtattcga gatgaaaaat ctggtaatac tattcttgat     2040

tacttaattg atgatggtat ttctaaccgt aatttcatgc aacttattca cgatgatgct     2100

ctttctttta aaaagaagat acagaaagca caaattattg gtgacgaaga taaaggtaat     2160

attaaagagg tcgttaagtc tttgccaggt agtcctgcga ttaaaaaagg tattttacaa     2220

agcataaaaa ttgtagatga attggtcaaa gtaatgggag gaagaaaacc cgagtcaatt     2280

gttgttgaga tggctcgtga aaatcaatat accaatcaag gtaagtctaa ttcccaacaa     2340

cgcttgaaac gtttagaaaa atctctcaaa gagttaggta gtaagatact taaggaaaat     2400

attcctgcaa aactttctaa aatagacaat aacgcacttc aaaatgatcg actttactta     2460

tactatcttc aaaatggaaa agatatgtat accggagatg atttagatat tgatagatta     2520

agtaattatg atattgatca tattattcct caagcttttt tgaaagataa ttctattgac     2580

aataaagtac ttgtttcatc tgctagtaac cgtggtaaat cagatgattt tccaagttta     2640

gaggttgtca aaaaaagaaa gacattttgg tatcaattat tgaaatcaaa attaatttct     2700

caacgaaaat ttgataatct gacaaaagct gaacggggag gattgttacc tgaggacaaa     2760

gctggtttta ttcaacgcca gttggttgaa acacgtcaaa taacaaaaca tgtagctcgt     2820

ttacttgatg agaaatttaa taataaaaaa gatgaaaata atagagcggt acgaacagta     2880

aaaattatta ccttgaaatc taccttagtt tctcaatttc gtaaggattt tgaactttat     2940

aaagttcgtg aaatcaatga ttttcatcat gctcatgatg cttacttgaa tgccgttata     3000

gcaagtgctt tacttaagaa ataccctaaa ctagagccag aatttgtgta cggtgattat     3060

ccaaaataca atagttttag agaaagaaag tccgctacag aaaaggtata tttctattca     3120

aatatcatga atatctttaa aaaatctatt tctttagctg atggtagagt tattgaaaga     3180

ccacttattg aggtaaatga ggagaccggc gaatccgttt ggaataaaga atctgattta     3240

gcaactgtaa ggagagtact ctcttatccg caagtaaatg ttgtgaaaaa agttgaggaa     3300

cagaatcacg gattggatag aggaaaacca aagggattgt ttaatgcaaa tctttcctca     3360

aagccaaaac caaatagtaa tgaaaattta gtaggtgcta aagagtatct tgaccccaaa     3420

aagtatgggg ggtatgctgg aatttctaat tcttttgctg ttcttgttaa agggacaatt     3480

gaaaaaggtg ctaagaaaaa aataacaaat gtactagaat ttcaaggtat ttctatttta     3540

gataggatta attatagaaa agataaactt aattttttac ttgaaaaagg ttataaagat     3600

attgagttaa ttattgaact acctaaatat agtttatttg aactttcaga tggttcacgt     3660

cgtatgttgg ctagtatttt gtcaacgaat aataagaggg gagagattca caaaggaaat     3720

cagatttttc tttcacagaa gtttgtgaaa ttactttatc atgctaagag aataagtaac     3780

acaattaatg agaatcatag aaaatatgtt gagaaccata aaaaagagtt tgaagaatta     3840

ttttactaca ttcttgagtt taatgagaat tatgttggag ctaaaaagaa tggtaaactt     3900

ttaaactctg cctttcaatc ttggcaaaat catagtatag atgaactctg tagtagtttt     3960

ataggaccta ccggaagtga aagaaagggg ctatttgaat taacctctcg tggaagtgct     4020

gctgattttg aatttttagg tgttaaaatt ccaaggtata gagactatac cccatcatcc     4080

ctattaaaag atgccacact tattcatcaa tctgttacag gcctctatga aacacgaata     4140

gaccttgcca aactaggaga gggttaa                                         4167


<210> 18
<211> 3249
<212> DNA
<213> Neisseria meningitidis

<400> 18
atggccgcct tcaagcccaa ccccatcaac tacatcctgg gcctggacat cggcatcgcc       60

agcgtgggct gggccatggt ggagatcgac gaggacgaga accccatctg cctgatcgac      120

ctgggtgtgc gcgtgttcga gcgcgctgag gtgcccaaga ctggtgacag tctggctatg      180

gctcgccggc ttgctcgctc tgttcggcgc cttactcgcc ggcgcgctca ccgccttctg      240

cgcgctcgcc gcctgctgaa gcgcgagggt gtgctgcagg ctgccgactt cgacgagaac      300

ggcctgatca agagcctgcc caacactcct tggcagctgc gcgctgccgc tctggaccgc      360

aagctgactc ctctggagtg gagcgccgtg ctgctgcacc tgatcaagca ccgcggctac      420

ctgagccagc gcaagaacga gggcgagacc gccgacaagg agctgggtgc tctgctgaag      480

ggcgtggccg acaacgccca cgccctgcag actggtgact tccgcactcc tgctgagctg      540

gccctgaaca agttcgagaa ggagagcggc cacatccgca accagcgcgg cgactacagc      600

cacaccttca gccgcaagga cctgcaggcc gagctgatcc tgctgttcga gaagcagaag      660

gagttcggca acccccacgt gagcggcggc ctgaaggagg gcatcgagac cctgctgatg      720

acccagcgcc ccgccctgag cggcgacgcc gtgcagaaga tgctgggcca ctgcaccttc      780

gagccagccg agcccaaggc cgccaagaac acctacaccg ccgagcgctt catctggctg      840

accaagctga acaacctgcg catcctggag cagggcagcg agcgccccct gaccgacacc      900

gagcgcgcca ccctgatgga cgagccctac cgcaagagca agctgaccta cgcccaggcc      960

cgcaagctgc tgggtctgga ggacaccgcc ttcttcaagg gcctgcgcta cggcaaggac     1020

aacgccgagg ccagcaccct gatggagatg aaggcctacc acgccatcag ccgcgccctg     1080

gagaaggagg gcctgaagga caagaagagt cctctgaacc tgagccccga gctgcaggac     1140

gagatcggca ccgccttcag cctgttcaag accgacgagg acatcaccgg ccgcctgaag     1200

gaccgcatcc agcccgagat cctggaggcc ctgctgaagc acatcagctt cgacaagttc     1260

gtgcagatca gcctgaaggc cctgcgccgc atcgtgcccc tgatggagca gggcaagcgc     1320

tacgacgagg cctgcgccga gatctacggc gaccactacg gcaagaagaa caccgaggag     1380

aagatctacc tgcctcctat ccccgccgac gagatccgca accccgtggt gctgcgcgcc     1440

ctgagccagg cccgcaaggt gatcaacggc gtggtgcgcc gctacggcag ccccgcccgc     1500

atccacatcg agaccgcccg cgaggtgggc aagagcttca aggaccgcaa ggagatcgag     1560

aagcgccagg aggagaaccg caaggaccgc gagaaggccg ccgccaagtt ccgcgagtac     1620

ttccccaact tcgtgggcga gcccaagagc aaggacatcc tgaagctgcg cctgtacgag     1680

cagcagcacg gcaagtgcct gtacagcggc aaggagatca acctgggccg cctgaacgag     1740

aagggctacg tggagatcga ccacgccctg cccttcagcc gcacctggga cgacagcttc     1800

aacaacaagg tgctggtgct gggcagcgag aaccagaaca agggcaacca gaccccctac     1860

gagtacttca acggcaagga caacagccgc gagtggcagg agttcaaggc ccgcgtggag     1920

accagccgct tcccccgcag caagaagcag cgcatcctgc tgcagaagtt cgacgaggac     1980

ggcttcaagg agcgcaacct gaacgacacc cgctacgtga accgcttcct gtgccagttc     2040

gtggccgacc gcatgcgcct gaccggcaag ggcaagaagc gcgtgttcgc cagcaacggc     2100

cagatcacca acctgctgcg cggcttctgg ggcctgcgca aggtgcgcgc cgagaacgac     2160

cgccaccacg ccctggacgc cgtggtggtg gcctgcagca ccgtggccat gcagcagaag     2220

atcacccgct tcgtgcgcta caaggagatg aacgccttcg acggtaaaac catcgacaag     2280

gagaccggcg aggtgctgca ccagaagacc cacttccccc agccctggga gttcttcgcc     2340

caggaggtga tgatccgcgt gttcggcaag cccgacggca agcccgagtt cgaggaggcc     2400

gacacccccg agaagctgcg caccctgctg gccgagaagc tgagcagccg ccctgaggcc     2460

gtgcacgagt acgtgactcc tctgttcgtg agccgcgccc ccaaccgcaa gatgagcggt     2520

cagggtcaca tggagaccgt gaagagcgcc aagcgcctgg acgagggcgt gagcgtgctg     2580

cgcgtgcccc tgacccagct gaagctgaag gacctggaga agatggtgaa ccgcgagcgc     2640

gagcccaagc tgtacgaggc cctgaaggcc cgcctggagg cccacaagga cgaccccgcc     2700

aaggccttcg ccgagccctt ctacaagtac gacaaggccg gcaaccgcac ccagcaggtg     2760

aaggccgtgc gcgtggagca ggtgcagaag accggcgtgt gggtgcgcaa ccacaacggc     2820

atcgccgaca acgccaccat ggtgcgcgtg gacgtgttcg agaagggcga caagtactac     2880

ctggtgccca tctacagctg gcaggtggcc aagggcatcc tgcccgaccg cgccgtggtg     2940

cagggcaagg acgaggagga ctggcagctg atcgacgaca gcttcaactt caagttcagc     3000

ctgcacccca acgacctggt ggaggtgatc accaagaagg cccgcatgtt cggctacttc     3060

gccagctgcc accgcggcac cggcaacatc aacatccgca tccacgacct ggaccacaag     3120

atcggcaaga acggcatcct ggagggcatc ggcgtgaaga ccgccctgag cttccagaag     3180

taccagatcg acgagctggg caaggagatc cgcccctgcc gcctgaagaa gcgccctcct     3240

gtgcgctaa                                                             3249


<210> 19
<211> 3249
<212> DNA
<213> Neisseria meningitidis

<400> 19
atggccgcct tcaagcccaa ccccatcaac tacatcctgg gcctggccat cggcatcgcc       60

agcgtgggct gggccatggt ggagatcgac gaggacgaga accccatctg cctgatcgac      120

ctgggtgtgc gcgtgttcga gcgcgctgag gtgcccaaga ctggtgacag tctggctatg      180

gctcgccggc ttgctcgctc tgttcggcgc cttactcgcc ggcgcgctca ccgccttctg      240

cgcgctcgcc gcctgctgaa gcgcgagggt gtgctgcagg ctgccgactt cgacgagaac      300

ggcctgatca agagcctgcc caacactcct tggcagctgc gcgctgccgc tctggaccgc      360

aagctgactc ctctggagtg gagcgccgtg ctgctgcacc tgatcaagca ccgcggctac      420

ctgagccagc gcaagaacga gggcgagacc gccgacaagg agctgggtgc tctgctgaag      480

ggcgtggccg acaacgccca cgccctgcag actggtgact tccgcactcc tgctgagctg      540

gccctgaaca agttcgagaa ggagagcggc cacatccgca accagcgcgg cgactacagc      600

cacaccttca gccgcaagga cctgcaggcc gagctgatcc tgctgttcga gaagcagaag      660

gagttcggca acccccacgt gagcggcggc ctgaaggagg gcatcgagac cctgctgatg      720

acccagcgcc ccgccctgag cggcgacgcc gtgcagaaga tgctgggcca ctgcaccttc      780

gagccagccg agcccaaggc cgccaagaac acctacaccg ccgagcgctt catctggctg      840

accaagctga acaacctgcg catcctggag cagggcagcg agcgccccct gaccgacacc      900

gagcgcgcca ccctgatgga cgagccctac cgcaagagca agctgaccta cgcccaggcc      960

cgcaagctgc tgggtctgga ggacaccgcc ttcttcaagg gcctgcgcta cggcaaggac     1020

aacgccgagg ccagcaccct gatggagatg aaggcctacc acgccatcag ccgcgccctg     1080

gagaaggagg gcctgaagga caagaagagt cctctgaacc tgagccccga gctgcaggac     1140

gagatcggca ccgccttcag cctgttcaag accgacgagg acatcaccgg ccgcctgaag     1200

gaccgcatcc agcccgagat cctggaggcc ctgctgaagc acatcagctt cgacaagttc     1260

gtgcagatca gcctgaaggc cctgcgccgc atcgtgcccc tgatggagca gggcaagcgc     1320

tacgacgagg cctgcgccga gatctacggc gaccactacg gcaagaagaa caccgaggag     1380

aagatctacc tgcctcctat ccccgccgac gagatccgca accccgtggt gctgcgcgcc     1440

ctgagccagg cccgcaaggt gatcaacggc gtggtgcgcc gctacggcag ccccgcccgc     1500

atccacatcg agaccgcccg cgaggtgggc aagagcttca aggaccgcaa ggagatcgag     1560

aagcgccagg aggagaaccg caaggaccgc gagaaggccg ccgccaagtt ccgcgagtac     1620

ttccccaact tcgtgggcga gcccaagagc aaggacatcc tgaagctgcg cctgtacgag     1680

cagcagcacg gcaagtgcct gtacagcggc aaggagatca acctgggccg cctgaacgag     1740

aagggctacg tggagatcgc cgctgccctg cccttcagcc gcacctggga cgacagcttc     1800

aacaacaagg tgctggtgct gggcagcgag gctcagaaca agggcaacca gaccccctac     1860

gagtacttca acggcaagga caacagccgc gagtggcagg agttcaaggc ccgcgtggag     1920

accagccgct tcccccgcag caagaagcag cgcatcctgc tgcagaagtt cgacgaggac     1980

ggcttcaagg agcgcaacct gaacgacacc cgctacgtga accgcttcct gtgccagttc     2040

gtggccgacc gcatgcgcct gaccggcaag ggcaagaagc gcgtgttcgc cagcaacggc     2100

cagatcacca acctgctgcg cggcttctgg ggcctgcgca aggtgcgcgc cgagaacgac     2160

cgccaccacg ccctggacgc cgtggtggtg gcctgcagca ccgtggccat gcagcagaag     2220

atcacccgct tcgtgcgcta caaggagatg aacgccttcg acggtaaaac catcgacaag     2280

gagaccggcg aggtgctgca ccagaagacc cacttccccc agccctggga gttcttcgcc     2340

caggaggtga tgatccgcgt gttcggcaag cccgacggca agcccgagtt cgaggaggcc     2400

gacacccccg agaagctgcg caccctgctg gccgagaagc tgagcagccg ccctgaggcc     2460

gtgcacgagt acgtgactcc tctgttcgtg agccgcgccc ccaaccgcaa gatgagcggt     2520

cagggtcaca tggagaccgt gaagagcgcc aagcgcctgg acgagggcgt gagcgtgctg     2580

cgcgtgcccc tgacccagct gaagctgaag gacctggaga agatggtgaa ccgcgagcgc     2640

gagcccaagc tgtacgaggc cctgaaggcc cgcctggagg cccacaagga cgaccccgcc     2700

aaggccttcg ccgagccctt ctacaagtac gacaaggccg gcaaccgcac ccagcaggtg     2760

aaggccgtgc gcgtggagca ggtgcagaag accggcgtgt gggtgcgcaa ccacaacggc     2820

atcgccgaca acgccaccat ggtgcgcgtg gacgtgttcg agaagggcga caagtactac     2880

ctggtgccca tctacagctg gcaggtggcc aagggcatcc tgcccgaccg cgccgtggtg     2940

cagggcaagg acgaggagga ctggcagctg atcgacgaca gcttcaactt caagttcagc     3000

ctgcacccca acgacctggt ggaggtgatc accaagaagg cccgcatgtt cggctacttc     3060

gccagctgcc accgcggcac cggcaacatc aacatccgca tccacgacct ggaccacaag     3120

atcggcaaga acggcatcct ggagggcatc ggcgtgaaga ccgccctgag cttccagaag     3180

taccagatcg acgagctggg caaggagatc cgcccctgcc gcctgaagaa gcgccctcct     3240

gtgcgctaa                                                             3249


<210> 20
<211> 3282
<212> DNA
<213> Neisseria meningitidis

<400> 20
atggccgcct tcaagcccaa ccccatcaac tacatcctgg gcctggacat cggcatcgcc       60

agcgtgggct gggccatggt ggagatcgac gaggacgaga accccatctg cctgatcgac      120

ctgggtgtgc gcgtgttcga gcgcgctgag gtgcccaaga ctggtgacag tctggctatg      180

gctcgccggc ttgctcgctc tgttcggcgc cttactcgcc ggcgcgctca ccgccttctg      240

cgcgctcgcc gcctgctgaa gcgcgagggt gtgctgcagg ctgccgactt cgacgagaac      300

ggcctgatca agagcctgcc caacactcct tggcagctgc gcgctgccgc tctggaccgc      360

aagctgactc ctctggagtg gagcgccgtg ctgctgcacc tgatcaagca ccgcggctac      420

ctgagccagc gcaagaacga gggcgagacc gccgacaagg agctgggtgc tctgctgaag      480

ggcgtggccg acaacgccca cgccctgcag actggtgact tccgcactcc tgctgagctg      540

gccctgaaca agttcgagaa ggagagcggc cacatccgca accagcgcgg cgactacagc      600

cacaccttca gccgcaagga cctgcaggcc gagctgatcc tgctgttcga gaagcagaag      660

gagttcggca acccccacgt gagcggcggc ctgaaggagg gcatcgagac cctgctgatg      720

acccagcgcc ccgccctgag cggcgacgcc gtgcagaaga tgctgggcca ctgcaccttc      780

gagccagccg agcccaaggc cgccaagaac acctacaccg ccgagcgctt catctggctg      840

accaagctga acaacctgcg catcctggag cagggcagcg agcgccccct gaccgacacc      900

gagcgcgcca ccctgatgga cgagccctac cgcaagagca agctgaccta cgcccaggcc      960

cgcaagctgc tgggtctgga ggacaccgcc ttcttcaagg gcctgcgcta cggcaaggac     1020

aacgccgagg ccagcaccct gatggagatg aaggcctacc acgccatcag ccgcgccctg     1080

gagaaggagg gcctgaagga caagaagagt cctctgaacc tgagccccga gctgcaggac     1140

gagatcggca ccgccttcag cctgttcaag accgacgagg acatcaccgg ccgcctgaag     1200

gaccgcatcc agcccgagat cctggaggcc ctgctgaagc acatcagctt cgacaagttc     1260

gtgcagatca gcctgaaggc cctgcgccgc atcgtgcccc tgatggagca gggcaagcgc     1320

tacgacgagg cctgcgccga gatctacggc gaccactacg gcaagaagaa caccgaggag     1380

aagatctacc tgcctcctat ccccgccgac gagatccgca accccgtggt gctgcgcgcc     1440

ctgagccagg cccgcaaggt gatcaacggc gtggtgcgcc gctacggcag ccccgcccgc     1500

atccacatcg agaccgcccg cgaggtgggc aagagcttca aggaccgcaa ggagatcgag     1560

aagcgccagg aggagaaccg caaggaccgc gagaaggccg ccgccaagtt ccgcgagtac     1620

ttccccaact tcgtgggcga gcccaagagc aaggacatcc tgaagctgcg cctgtacgag     1680

cagcagcacg gcaagtgcct gtacagcggc aaggagatca acctgggccg cctgaacgag     1740

aagggctacg tggagatcga ccacgccctg cccttcagcc gcacctggga cgacagcttc     1800

aacaacaagg tgctggtgct gggcagcgag aaccagaaca agggcaacca gaccccctac     1860

gagtacttca acggcaagga caacagccgc gagtggcagg agttcaaggc ccgcgtggag     1920

accagccgct tcccccgcag caagaagcag cgcatcctgc tgcagaagtt cgacgaggac     1980

ggcttcaagg agcgcaacct gaacgacacc cgctacgtga accgcttcct gtgccagttc     2040

gtggccgacc gcatgcgcct gaccggcaag ggcaagaagc gcgtgttcgc cagcaacggc     2100

cagatcacca acctgctgcg cggcttctgg ggcctgcgca aggtgcgcgc cgagaacgac     2160

cgccaccacg ccctggacgc cgtggtggtg gcctgcagca ccgtggccat gcagcagaag     2220

atcacccgct tcgtgcgcta caaggagatg aacgccttcg acggtaaaac catcgacaag     2280

gagaccggcg aggtgctgca ccagaagacc cacttccccc agccctggga gttcttcgcc     2340

caggaggtga tgatccgcgt gttcggcaag cccgacggca agcccgagtt cgaggaggcc     2400

gacacccccg agaagctgcg caccctgctg gccgagaagc tgagcagccg ccctgaggcc     2460

gtgcacgagt acgtgactcc tctgttcgtg agccgcgccc ccaaccgcaa gatgagcggt     2520

cagggtcaca tggagaccgt gaagagcgcc aagcgcctgg acgagggcgt gagcgtgctg     2580

cgcgtgcccc tgacccagct gaagctgaag gacctggaga agatggtgaa ccgcgagcgc     2640

gagcccaagc tgtacgaggc cctgaaggcc cgcctggagg cccacaagga cgaccccgcc     2700

aaggccttcg ccgagccctt ctacaagtac gacaaggccg gcaaccgcac ccagcaggtg     2760

aaggccgtgc gcgtggagca ggtgcagaag accggcgtgt gggtgcgcaa ccacaacggc     2820

atcgccgaca acgccaccat ggtgcgcgtg gacgtgttcg agaagggcga caagtactac     2880

ctggtgccca tctacagctg gcaggtggcc aagggcatcc tgcccgaccg cgccgtggtg     2940

cagggcaagg acgaggagga ctggcagctg atcgacgaca gcttcaactt caagttcagc     3000

ctgcacccca acgacctggt ggaggtgatc accaagaagg cccgcatgtt cggctacttc     3060

gccagctgcc accgcggcac cggcaacatc aacatccgca tccacgacct ggaccacaag     3120

atcggcaaga acggcatcct ggagggcatc ggcgtgaaga ccgccctgag cttccagaag     3180

taccagatcg acgagctggg caaggagatc cgcccctgcc gcctgaagaa gcgccctcct     3240

gtgcgcagca gggctgaccc caagaagaag aggaaggtgt ga                        3282


<210> 21
<211> 3342
<212> DNA
<213> Neisseria meningitidis

<400> 21
atggccgcct tcaagcccaa ccccatcaac tacatcctgg gcctggacat cggcatcgcc       60

agcgtgggct gggccatggt ggagatcgac gaggacgaga accccatctg cctgatcgac      120

ctgggtgtgc gcgtgttcga gcgcgctgag gtgcccaaga ctggtgacag tctggctatg      180

gctcgccggc ttgctcgctc tgttcggcgc cttactcgcc ggcgcgctca ccgccttctg      240

cgcgctcgcc gcctgctgaa gcgcgagggt gtgctgcagg ctgccgactt cgacgagaac      300

ggcctgatca agagcctgcc caacactcct tggcagctgc gcgctgccgc tctggaccgc      360

aagctgactc ctctggagtg gagcgccgtg ctgctgcacc tgatcaagca ccgcggctac      420

ctgagccagc gcaagaacga gggcgagacc gccgacaagg agctgggtgc tctgctgaag      480

ggcgtggccg acaacgccca cgccctgcag actggtgact tccgcactcc tgctgagctg      540

gccctgaaca agttcgagaa ggagagcggc cacatccgca accagcgcgg cgactacagc      600

cacaccttca gccgcaagga cctgcaggcc gagctgatcc tgctgttcga gaagcagaag      660

gagttcggca acccccacgt gagcggcggc ctgaaggagg gcatcgagac cctgctgatg      720

acccagcgcc ccgccctgag cggcgacgcc gtgcagaaga tgctgggcca ctgcaccttc      780

gagccagccg agcccaaggc cgccaagaac acctacaccg ccgagcgctt catctggctg      840

accaagctga acaacctgcg catcctggag cagggcagcg agcgccccct gaccgacacc      900

gagcgcgcca ccctgatgga cgagccctac cgcaagagca agctgaccta cgcccaggcc      960

cgcaagctgc tgggtctgga ggacaccgcc ttcttcaagg gcctgcgcta cggcaaggac     1020

aacgccgagg ccagcaccct gatggagatg aaggcctacc acgccatcag ccgcgccctg     1080

gagaaggagg gcctgaagga caagaagagt cctctgaacc tgagccccga gctgcaggac     1140

gagatcggca ccgccttcag cctgttcaag accgacgagg acatcaccgg ccgcctgaag     1200

gaccgcatcc agcccgagat cctggaggcc ctgctgaagc acatcagctt cgacaagttc     1260

gtgcagatca gcctgaaggc cctgcgccgc atcgtgcccc tgatggagca gggcaagcgc     1320

tacgacgagg cctgcgccga gatctacggc gaccactacg gcaagaagaa caccgaggag     1380

aagatctacc tgcctcctat ccccgccgac gagatccgca accccgtggt gctgcgcgcc     1440

ctgagccagg cccgcaaggt gatcaacggc gtggtgcgcc gctacggcag ccccgcccgc     1500

atccacatcg agaccgcccg cgaggtgggc aagagcttca aggaccgcaa ggagatcgag     1560

aagcgccagg aggagaaccg caaggaccgc gagaaggccg ccgccaagtt ccgcgagtac     1620

ttccccaact tcgtgggcga gcccaagagc aaggacatcc tgaagctgcg cctgtacgag     1680

cagcagcacg gcaagtgcct gtacagcggc aaggagatca acctgggccg cctgaacgag     1740

aagggctacg tggagatcga ccacgccctg cccttcagcc gcacctggga cgacagcttc     1800

aacaacaagg tgctggtgct gggcagcgag aaccagaaca agggcaacca gaccccctac     1860

gagtacttca acggcaagga caacagccgc gagtggcagg agttcaaggc ccgcgtggag     1920

accagccgct tcccccgcag caagaagcag cgcatcctgc tgcagaagtt cgacgaggac     1980

ggcttcaagg agcgcaacct gaacgacacc cgctacgtga accgcttcct gtgccagttc     2040

gtggccgacc gcatgcgcct gaccggcaag ggcaagaagc gcgtgttcgc cagcaacggc     2100

cagatcacca acctgctgcg cggcttctgg ggcctgcgca aggtgcgcgc cgagaacgac     2160

cgccaccacg ccctggacgc cgtggtggtg gcctgcagca ccgtggccat gcagcagaag     2220

atcacccgct tcgtgcgcta caaggagatg aacgccttcg acggtaaaac catcgacaag     2280

gagaccggcg aggtgctgca ccagaagacc cacttccccc agccctggga gttcttcgcc     2340

caggaggtga tgatccgcgt gttcggcaag cccgacggca agcccgagtt cgaggaggcc     2400

gacacccccg agaagctgcg caccctgctg gccgagaagc tgagcagccg ccctgaggcc     2460

gtgcacgagt acgtgactcc tctgttcgtg agccgcgccc ccaaccgcaa gatgagcggt     2520

cagggtcaca tggagaccgt gaagagcgcc aagcgcctgg acgagggcgt gagcgtgctg     2580

cgcgtgcccc tgacccagct gaagctgaag gacctggaga agatggtgaa ccgcgagcgc     2640

gagcccaagc tgtacgaggc cctgaaggcc cgcctggagg cccacaagga cgaccccgcc     2700

aaggccttcg ccgagccctt ctacaagtac gacaaggccg gcaaccgcac ccagcaggtg     2760

aaggccgtgc gcgtggagca ggtgcagaag accggcgtgt gggtgcgcaa ccacaacggc     2820

atcgccgaca acgccaccat ggtgcgcgtg gacgtgttcg agaagggcga caagtactac     2880

ctggtgccca tctacagctg gcaggtggcc aagggcatcc tgcccgaccg cgccgtggtg     2940

cagggcaagg acgaggagga ctggcagctg atcgacgaca gcttcaactt caagttcagc     3000

ctgcacccca acgacctggt ggaggtgatc accaagaagg cccgcatgtt cggctacttc     3060

gccagctgcc accgcggcac cggcaacatc aacatccgca tccacgacct ggaccacaag     3120

atcggcaaga acggcatcct ggagggcatc ggcgtgaaga ccgccctgag cttccagaag     3180

taccagatcg acgagctggg caaggagatc cgcccctgcc gcctgaagaa gcgccctcct     3240

gtgcgcgcgg ccgcagatcc aaaaaagaag agaaaggtag atccaaaaaa gaagagaaag     3300

gtagatccaa aaaagaagag aaaggtagat acggccgcat ag                        3342


<210> 22
<211> 3468
<212> DNA
<213> Neisseria meningitidis

<400> 22
atggccgcct tcaagcccaa ccccatcaac tacatcctgg gcctggccat cggcatcgcc       60

agcgtgggct gggccatggt ggagatcgac gaggacgaga accccatctg cctgatcgac      120

ctgggtgtgc gcgtgttcga gcgcgctgag gtgcccaaga ctggtgacag tctggctatg      180

gctcgccggc ttgctcgctc tgttcggcgc cttactcgcc ggcgcgctca ccgccttctg      240

cgcgctcgcc gcctgctgaa gcgcgagggt gtgctgcagg ctgccgactt cgacgagaac      300

ggcctgatca agagcctgcc caacactcct tggcagctgc gcgctgccgc tctggaccgc      360

aagctgactc ctctggagtg gagcgccgtg ctgctgcacc tgatcaagca ccgcggctac      420

ctgagccagc gcaagaacga gggcgagacc gccgacaagg agctgggtgc tctgctgaag      480

ggcgtggccg acaacgccca cgccctgcag actggtgact tccgcactcc tgctgagctg      540

gccctgaaca agttcgagaa ggagagcggc cacatccgca accagcgcgg cgactacagc      600

cacaccttca gccgcaagga cctgcaggcc gagctgatcc tgctgttcga gaagcagaag      660

gagttcggca acccccacgt gagcggcggc ctgaaggagg gcatcgagac cctgctgatg      720

acccagcgcc ccgccctgag cggcgacgcc gtgcagaaga tgctgggcca ctgcaccttc      780

gagccagccg agcccaaggc cgccaagaac acctacaccg ccgagcgctt catctggctg      840

accaagctga acaacctgcg catcctggag cagggcagcg agcgccccct gaccgacacc      900

gagcgcgcca ccctgatgga cgagccctac cgcaagagca agctgaccta cgcccaggcc      960

cgcaagctgc tgggtctgga ggacaccgcc ttcttcaagg gcctgcgcta cggcaaggac     1020

aacgccgagg ccagcaccct gatggagatg aaggcctacc acgccatcag ccgcgccctg     1080

gagaaggagg gcctgaagga caagaagagt cctctgaacc tgagccccga gctgcaggac     1140

gagatcggca ccgccttcag cctgttcaag accgacgagg acatcaccgg ccgcctgaag     1200

gaccgcatcc agcccgagat cctggaggcc ctgctgaagc acatcagctt cgacaagttc     1260

gtgcagatca gcctgaaggc cctgcgccgc atcgtgcccc tgatggagca gggcaagcgc     1320

tacgacgagg cctgcgccga gatctacggc gaccactacg gcaagaagaa caccgaggag     1380

aagatctacc tgcctcctat ccccgccgac gagatccgca accccgtggt gctgcgcgcc     1440

ctgagccagg cccgcaaggt gatcaacggc gtggtgcgcc gctacggcag ccccgcccgc     1500

atccacatcg agaccgcccg cgaggtgggc aagagcttca aggaccgcaa ggagatcgag     1560

aagcgccagg aggagaaccg caaggaccgc gagaaggccg ccgccaagtt ccgcgagtac     1620

ttccccaact tcgtgggcga gcccaagagc aaggacatcc tgaagctgcg cctgtacgag     1680

cagcagcacg gcaagtgcct gtacagcggc aaggagatca acctgggccg cctgaacgag     1740

aagggctacg tggagatcgc cgctgccctg cccttcagcc gcacctggga cgacagcttc     1800

aacaacaagg tgctggtgct gggcagcgag gctcagaaca agggcaacca gaccccctac     1860

gagtacttca acggcaagga caacagccgc gagtggcagg agttcaaggc ccgcgtggag     1920

accagccgct tcccccgcag caagaagcag cgcatcctgc tgcagaagtt cgacgaggac     1980

ggcttcaagg agcgcaacct gaacgacacc cgctacgtga accgcttcct gtgccagttc     2040

gtggccgacc gcatgcgcct gaccggcaag ggcaagaagc gcgtgttcgc cagcaacggc     2100

cagatcacca acctgctgcg cggcttctgg ggcctgcgca aggtgcgcgc cgagaacgac     2160

cgccaccacg ccctggacgc cgtggtggtg gcctgcagca ccgtggccat gcagcagaag     2220

atcacccgct tcgtgcgcta caaggagatg aacgccttcg acggtaaaac catcgacaag     2280

gagaccggcg aggtgctgca ccagaagacc cacttccccc agccctggga gttcttcgcc     2340

caggaggtga tgatccgcgt gttcggcaag cccgacggca agcccgagtt cgaggaggcc     2400

gacacccccg agaagctgcg caccctgctg gccgagaagc tgagcagccg ccctgaggcc     2460

gtgcacgagt acgtgactcc tctgttcgtg agccgcgccc ccaaccgcaa gatgagcggt     2520

cagggtcaca tggagaccgt gaagagcgcc aagcgcctgg acgagggcgt gagcgtgctg     2580

cgcgtgcccc tgacccagct gaagctgaag gacctggaga agatggtgaa ccgcgagcgc     2640

gagcccaagc tgtacgaggc cctgaaggcc cgcctggagg cccacaagga cgaccccgcc     2700

aaggccttcg ccgagccctt ctacaagtac gacaaggccg gcaaccgcac ccagcaggtg     2760

aaggccgtgc gcgtggagca ggtgcagaag accggcgtgt gggtgcgcaa ccacaacggc     2820

atcgccgaca acgccaccat ggtgcgcgtg gacgtgttcg agaagggcga caagtactac     2880

ctggtgccca tctacagctg gcaggtggcc aagggcatcc tgcccgaccg cgccgtggtg     2940

cagggcaagg acgaggagga ctggcagctg atcgacgaca gcttcaactt caagttcagc     3000

ctgcacccca acgacctggt ggaggtgatc accaagaagg cccgcatgtt cggctacttc     3060

gccagctgcc accgcggcac cggcaacatc aacatccgca tccacgacct ggaccacaag     3120

atcggcaaga acggcatcct ggagggcatc ggcgtgaaga ccgccctgag cttccagaag     3180

taccagatcg acgagctggg caaggagatc cgcccctgcc gcctgaagaa gcgccctcct     3240

gtgcgcagca gggctgaccc caagaagaag aggaaggtgg aggccagcgg ttccggacgg     3300

gctgacgcat tggacgattt tgatctggat atgctgggaa gtgacgccct cgatgatttt     3360

gaccttgaca tgcttggttc ggatgccctt gatgactttg acctcgacat gctcggcagt     3420

gacgcccttg atgatttcga cctggacatg ctgattaact ctagatga                  3468


<210> 23
<211> 3489
<212> DNA
<213> Neisseria meningitidis

<400> 23
atgcccaaga agaagaggaa ggtggccgcc ttcaagccca accccatcaa ctacatcctg       60

ggcctggcca tcggcatcgc cagcgtgggc tgggccatgg tggagatcga cgaggacgag      120

aaccccatct gcctgatcga cctgggtgtg cgcgtgttcg agcgcgctga ggtgcccaag      180

actggtgaca gtctggctat ggctcgccgg cttgctcgct ctgttcggcg ccttactcgc      240

cggcgcgctc accgccttct gcgcgctcgc cgcctgctga agcgcgaggg tgtgctgcag      300

gctgccgact tcgacgagaa cggcctgatc aagagcctgc ccaacactcc ttggcagctg      360

cgcgctgccg ctctggaccg caagctgact cctctggagt ggagcgccgt gctgctgcac      420

ctgatcaagc accgcggcta cctgagccag cgcaagaacg agggcgagac cgccgacaag      480

gagctgggtg ctctgctgaa gggcgtggcc gacaacgccc acgccctgca gactggtgac      540

ttccgcactc ctgctgagct ggccctgaac aagttcgaga aggagagcgg ccacatccgc      600

aaccagcgcg gcgactacag ccacaccttc agccgcaagg acctgcaggc cgagctgatc      660

ctgctgttcg agaagcagaa ggagttcggc aacccccacg tgagcggcgg cctgaaggag      720

ggcatcgaga ccctgctgat gacccagcgc cccgccctga gcggcgacgc cgtgcagaag      780

atgctgggcc actgcacctt cgagccagcc gagcccaagg ccgccaagaa cacctacacc      840

gccgagcgct tcatctggct gaccaagctg aacaacctgc gcatcctgga gcagggcagc      900

gagcgccccc tgaccgacac cgagcgcgcc accctgatgg acgagcccta ccgcaagagc      960

aagctgacct acgcccaggc ccgcaagctg ctgggtctgg aggacaccgc cttcttcaag     1020

ggcctgcgct acggcaagga caacgccgag gccagcaccc tgatggagat gaaggcctac     1080

cacgccatca gccgcgccct ggagaaggag ggcctgaagg acaagaagag tcctctgaac     1140

ctgagccccg agctgcagga cgagatcggc accgccttca gcctgttcaa gaccgacgag     1200

gacatcaccg gccgcctgaa ggaccgcatc cagcccgaga tcctggaggc cctgctgaag     1260

cacatcagct tcgacaagtt cgtgcagatc agcctgaagg ccctgcgccg catcgtgccc     1320

ctgatggagc agggcaagcg ctacgacgag gcctgcgccg agatctacgg cgaccactac     1380

ggcaagaaga acaccgagga gaagatctac ctgcctccta tccccgccga cgagatccgc     1440

aaccccgtgg tgctgcgcgc cctgagccag gcccgcaagg tgatcaacgg cgtggtgcgc     1500

cgctacggca gccccgcccg catccacatc gagaccgccc gcgaggtggg caagagcttc     1560

aaggaccgca aggagatcga gaagcgccag gaggagaacc gcaaggaccg cgagaaggcc     1620

gccgccaagt tccgcgagta cttccccaac ttcgtgggcg agcccaagag caaggacatc     1680

ctgaagctgc gcctgtacga gcagcagcac ggcaagtgcc tgtacagcgg caaggagatc     1740

aacctgggcc gcctgaacga gaagggctac gtggagatcg ccgctgccct gcccttcagc     1800

cgcacctggg acgacagctt caacaacaag gtgctggtgc tgggcagcga ggctcagaac     1860

aagggcaacc agacccccta cgagtacttc aacggcaagg acaacagccg cgagtggcag     1920

gagttcaagg cccgcgtgga gaccagccgc ttcccccgca gcaagaagca gcgcatcctg     1980

ctgcagaagt tcgacgagga cggcttcaag gagcgcaacc tgaacgacac ccgctacgtg     2040

aaccgcttcc tgtgccagtt cgtggccgac cgcatgcgcc tgaccggcaa gggcaagaag     2100

cgcgtgttcg ccagcaacgg ccagatcacc aacctgctgc gcggcttctg gggcctgcgc     2160

aaggtgcgcg ccgagaacga ccgccaccac gccctggacg ccgtggtggt ggcctgcagc     2220

accgtggcca tgcagcagaa gatcacccgc ttcgtgcgct acaaggagat gaacgccttc     2280

gacggtaaaa ccatcgacaa ggagaccggc gaggtgctgc accagaagac ccacttcccc     2340

cagccctggg agttcttcgc ccaggaggtg atgatccgcg tgttcggcaa gcccgacggc     2400

aagcccgagt tcgaggaggc cgacaccccc gagaagctgc gcaccctgct ggccgagaag     2460

ctgagcagcc gccctgaggc cgtgcacgag tacgtgactc ctctgttcgt gagccgcgcc     2520

cccaaccgca agatgagcgg tcagggtcac atggagaccg tgaagagcgc caagcgcctg     2580

gacgagggcg tgagcgtgct gcgcgtgccc ctgacccagc tgaagctgaa ggacctggag     2640

aagatggtga accgcgagcg cgagcccaag ctgtacgagg ccctgaaggc ccgcctggag     2700

gcccacaagg acgaccccgc caaggccttc gccgagccct tctacaagta cgacaaggcc     2760

ggcaaccgca cccagcaggt gaaggccgtg cgcgtggagc aggtgcagaa gaccggcgtg     2820

tgggtgcgca accacaacgg catcgccgac aacgccacca tggtgcgcgt ggacgtgttc     2880

gagaagggcg acaagtacta cctggtgccc atctacagct ggcaggtggc caagggcatc     2940

ctgcccgacc gcgccgtggt gcagggcaag gacgaggagg actggcagct gatcgacgac     3000

agcttcaact tcaagttcag cctgcacccc aacgacctgg tggaggtgat caccaagaag     3060

gcccgcatgt tcggctactt cgccagctgc caccgcggca ccggcaacat caacatccgc     3120

atccacgacc tggaccacaa gatcggcaag aacggcatcc tggagggcat cggcgtgaag     3180

accgccctga gcttccagaa gtaccagatc gacgagctgg gcaaggagat ccgcccctgc     3240

cgcctgaaga agcgccctcc tgtgcgcagc agggctgacc ccaagaagaa gaggaaggtg     3300

gaggccagcg gttccggacg ggctgacgca ttggacgatt ttgatctgga tatgctggga     3360

agtgacgccc tcgatgattt tgaccttgac atgcttggtt cggatgccct tgatgacttt     3420

gacctcgaca tgctcggcag tgacgccctt gatgatttcg acctggacat gctgattaac     3480

tctagatga                                                             3489


<210> 24
<211> 3249
<212> DNA
<213> Neisseria meningitidis

<400> 24
atggctgcct tcaaacctaa ttcaatcaac tacatcctcg gcctcgatat cggcatcgca       60

tccgtcggct gggcgatggt agaaattgac gaagaagaaa accccatccg cctgattgat      120

ttgggcgtgc gcgtatttga gcgtgccgaa gtaccgaaaa caggcgactc ccttgccatg      180

gcaaggcgtt tggcgcgcag tgttcgccgc ctgacccgcc gtcgcgccca ccgcctgctt      240

cggacccgcc gcctattgaa acgcgaaggc gtattacaag ccgccaattt tgacgaaaac      300

ggcttgatta aatccttacc gaatacacca tggcaacttc gcgcagccgc attagaccgc      360

aaactgacgc ctttagagtg gtcggcagtc ttgttgcatt taatcaaaca tcgcggctat      420

ttatcgcaac ggaaaaacga gggcgaaact gccgataagg agcttggcgc tttgcttaaa      480

ggcgtagccg gcaatgccca tgccttacag acaggcgatt tccgcacacc ggccgaattg      540

gctttaaata aatttgagaa agaaagcggc catatccgca atcagcgcag cgattattcg      600

catacgttca gccgcaaaga tttacaggcg gagctgattt tgctgtttga aaaacaaaaa      660

gaatttggca atccgcatgt ttcaggcggc cttaaagaag gtattgaaac cctactgatg      720

acgcaacgcc ctgccctgtc cggcgatgcc gttcaaaaaa tgttggggca ttgcaccttc      780

gaaccggcag agccgaaagc cgctaaaaac acctacacag ccgaacgttt catctggctg      840

accaagctga acaacctgcg tattttagag caaggcagcg agcggccatt gaccgatacc      900

gaacgcgcca cgcttatgga cgagccatac agaaaatcca aactgactta cgcacaagcc      960

cgtaagctgc tgggtttaga agataccgcc tttttcaaag gcttgcgcta tggtaaagac     1020

aatgccgaag cctcaacatt gatggaaatg aaggcctacc atgccatcag ccgtgcactg     1080

gaaaaagaag gattgaaaga caaaaaatcc ccattaaacc tttctcccga attacaagac     1140

gaaatcggca cggcattctc cctgttcaaa accgatgaag acattacagg ccgtctgaaa     1200

gaccgtatac agcccgaaat cttagaagcg ctgttgaaac acatcagctt cgataagttc     1260

gtccaaattt ccttgaaagc attgcgccga attgtgcctc taatggaaca aggcaaacgt     1320

tacgatgaag cctgcgccga aatctacgga gaccattacg gcaagaagaa tacggaagaa     1380

aagatttatc tgccgccgat tcccgccgac gaaatccgca accccgtcgt cttgcgcgcc     1440

ttatctcaag cacgtaaggt cattaacggc gtggtacgcc gttacggctc cccagctcgt     1500

atccatattg aaactgcaag ggaagtaggt aaatcgttta aagaccgcaa agaaattgag     1560

aaacgccaag aagaaaaccg caaagaccgg gaaaaagccg ccgccaaatt ccgagagtat     1620

ttccccaatt ttgtcggaga acccaaatcc aaagatattc tgaaactgcg cctgtacgag     1680

caacaacacg gcaaatgcct gtattcgggc aaagaaatca acttaggccg tctgaacgaa     1740

aaaggctatg tcgaaatcga ccatgccctg ccgttctcgc gcacatggga cgacagtttc     1800

aacaataaag tactggtatt gggcagcgaa aaccaaaaca aaggcaatca aaccccttac     1860

gaatacttca acggcaaaga caacagccgc gaatggcagg aatttaaagc gcgtgtcgaa     1920

accagccgtt tcccgcgcag taaaaaacaa cggattctgc tgcaaaaatt cgatgaagac     1980

ggctttaaag aacgcaatct gaacgacacg cgctacgtca accgtttcct gtgtcaattt     2040

gttgccgacc gtatgcggct gacaggtaaa ggcaagaaac gtgtctttgc atccaacgga     2100

caaattacca atctgttgcg cggcttttgg ggattgcgca aagtgcgtgc ggaaaacgac     2160

cgccatcacg ccttggacgc cgtcgtcgtt gcctgctcga ccgttgccat gcagcagaaa     2220

attacccgtt ttgtacgcta taaagagatg aacgcgtttg acggtaaaac catagacaaa     2280

gaaacaggag aagtgctgca tcaaaaaaca cacttcccac aaccttggga atttttcgca     2340

caagaagtca tgattcgcgt cttcggcaaa ccggacggca aacccgaatt cgaagaagcc     2400

gataccctag aaaaactgcg cacgttgctt gccgaaaaat tatcatctcg ccccgaagcc     2460

gtacacgaat acgttacgcc actgtttgtt tcacgcgcgc ccaatcggaa gatgagcggg     2520

caagggcata tggagaccgt caaatccgcc aaacgactgg acgaaggcgt cagcgtgttg     2580

cgcgtaccgc tgacacagtt aaaactgaaa gacttggaaa aaatggtcaa tcgggagcgc     2640

gaacctaagc tatacgaagc actgaaagca cggctggaag cacataaaga cgatcctgcc     2700

aaagcctttg ccgagccgtt ttacaaatac gataaagcag gcaaccgcac ccaacaggta     2760

aaagccgtac gcgtagagca agtacagaaa accggcgtat gggtgcgcaa ccataacggt     2820

attgccgaca acgcaaccat ggtgcgcgta gatgtgtttg agaaaggcga caagtattat     2880

ctggtaccga tttacagttg gcaggtagcg aaagggattt tgccggatag ggctgttgta     2940

caaggaaaag atgaagaaga ttggcaactt attgatgata gtttcaactt taaattctca     3000

ttacacccta atgatttagt cgaggttata acaaaaaaag ctagaatgtt tggttacttt     3060

gccagctgcc atcgaggcac aggtaatatc aatatacgca ttcatgatct tgatcataaa     3120

attggcaaaa atggaatact ggaaggtatc ggcgtcaaaa ccgccctttc attccaaaaa     3180

taccaaattg acgaactggg caaagaaatc agaccatgcc gtctgaaaaa acgcccgcct     3240

gtccgttaa                                                             3249


<210> 25
<211> 4188
<212> DNA
<213> Treponema denticola

<400> 25
atgaaaaagg aaattaagga ttattttctc ggattggatg taggaaccgg atcggttggt       60

tgggcagtta ctgatactga ctataaactc ttaaaggcta atcgtaaaga cctttgggga      120

atgaggtgtt ttgagacggc ggaaactgcg gaagtgagaa ggcttcacag gggggctagg      180

cgccgtattg agagaagaaa aaaaagaata aagctgcttc aagagctttt ttcccaagaa      240

attgcaaaaa cagatgaggg atttttccaa agaatgaagg aaagcccttt ctatgcagaa      300

gacaagacta tattacagga aaacactctt tttaatgata aagattttgc cgataagacc      360

taccataaag cctatcctac cataaaccat ctgataaagg cttggattga aaacaaggta      420

aagccggatc caaggttatt atacttagcc tgtcataata ttataaaaaa aagaggtcat      480

tttttattcg agggcgattt cgattcagaa aatcagtttg atacttctat acaagccctt      540

tttgaatatc tgcgtgaaga tatggaagtc gatattgatg ccgatagcca aaaagtaaaa      600

gagattttaa aggatagctc tttaaaaaat tccgaaaaac aaagccgcct aaataagatt      660

ttaggactga aaccctccga caaacaaaaa aaagctatta ctaatttaat atcaggcaac      720

aaaataaact ttgccgatct ttatgataat ccggatttaa aggatgcgga gaaaaatagt      780

atatcttttt cgaaagatga ttttgatgct ttgagtgatg atcttgcttc cattctagga      840

gattcttttg agcttttatt aaaagcaaag gctgtatata actgctcggt tctttccaag      900

gtaataggcg atgaacagta tctttctttt gcaaaggtaa aaatatatga aaagcataaa      960

accgatttga ctaaattaaa aaatgttata aaaaagcatt tcccaaaaga ttataaaaaa     1020

gtattcggat acaataaaaa cgaaaaaaat aacaacaatt actccggata tgtaggcgta     1080

tgtaaaacca agagtaaaaa actaattata aacaattctg taaatcaaga agatttttac     1140

aaatttttaa aaactatcct ttcagcaaaa tccgagataa aggaagtaaa tgatatattg     1200

accgaaattg aaacagggac ttttttacct aaacagatat ctaaaagcaa tgcggagatt     1260

ccttatcaat tacgcaagat ggagctggaa aaaatattat caaacgcaga aaaacatttt     1320

tcctttttaa aacaaaaaga tgaaaaaggt ttatctcaca gtgaaaagat tataatgctt     1380

ttaacattta agattcctta ttatattgga cctataaacg ataaccataa aaaatttttt     1440

cccgatagat gctgggtagt aaaaaaagaa aaatcgcctt ccggtaaaac tactccatgg     1500

aacttttttg atcatatcga taaagaaaaa acagctgaag catttattac aagcagaacc     1560

aatttttgca catatttagt aggggaatcc gttttaccaa aaagttctct tttatattcc     1620

gagtataccg ttttaaatga aatcaacaat ttacagatta tcattgacgg aaaaaatatc     1680

tgcgatatta aactaaaaca aaaaatatac gaagatttat ttaaaaaata taaaaagatt     1740

acacaaaaac aaatttcaac ttttatcaaa cacgaaggta tttgcaataa aactgatgaa     1800

gtaattattc taggtatcga taaagaatgt acatcttcgt taaaatcata tatagaactt     1860

aaaaacatat tcggaaagca agtagatgaa atttctacaa agaatatgct tgaagaaatt     1920

atacgatggg ctactatcta tgatgaagga gaaggcaaaa caatacttaa aacaaaaata     1980

aaagccgaat atggaaaata ttgttctgat gaacagatca aaaaaattct aaatcttaaa     2040

ttttcaggtt ggggccgctt gtcacgcaaa ttccttgaaa ccgtcacatc agaaatgccg     2100

ggttttagcg aaccggtaaa tataataact gcaatgcggg aaactcaaaa taatttaatg     2160

gagttgctta gcagtgaatt tacatttact gaaaatatta aaaagataaa ttcgggattt     2220

gaagatgctg aaaagcaatt ttcatatgac ggtttggtta agcctctgtt tttatcacca     2280

tcggtaaaaa aaatgttgtg gcagactcta aagcttgtaa aagaaatatc gcatattacc     2340

caagcccctc ctaaaaaaat atttatagaa atggcaaagg gtgcagagct tgaacctgcg     2400

aggactaaga caagattaaa aattttacaa gacttataca ataactgtaa aaatgatgcg     2460

gatgctttta gttccgagat aaaagacctt tcaggtaaaa tagaaaatga agataattta     2520

aggcttcgaa gcgacaaact ttatctttat tacacgcagc ttggaaagtg catgtattgc     2580

ggtaaaccga ttgaaatagg ccatgtattt gatacaagca actatgatat agatcatatt     2640

tatccccaat ccaagattaa agatgacagt ataagtaatc gggttttagt atgcagcagc     2700

tgcaataaaa ataaggaaga taaatatcct ttgaagtctg aaattcaatc aaagcaaagg     2760

ggcttttgga attttttaca acgaaataac tttataagcc ttgaaaaatt gaataggtta     2820

acaagggcca ctccaatctc ggatgacgaa acggcaaaat tcattgccag acagcttgta     2880

gaaacaagac aggcgacaaa agtagctgca aaagtattag aaaaaatgtt tcccgaaact     2940

aagattgttt attctaaagc tgaaaccgta tcaatgttta gaaataaatt cgatattgta     3000

aaatgcagag aaataaacga ttttcatcat gctcatgatg catatttaaa tattgttgtc     3060

ggaaatgtat ataatacaaa atttacaaat aatccttgga actttataaa ggagaaacgg     3120

gataatccaa agattgccga tacttacaat tattataaag tttttgatta tgatgtaaaa     3180

agaaataata ttacggcatg ggaaaaagga aaaacaatta tcactgtgaa ggatatgctt     3240

aaaagaaata cccctattta tacacgccaa gccgcctgca aaaaaggaga actctttaac     3300

caaaccatta tgaaaaaagg attgggccag catcctctaa aaaaagaagg tcctttttct     3360

aatatttcaa aatatggggg ctataataaa gtctctgctg catattatac tcttatagaa     3420

tacgaagaaa aagggaataa aatacgaagc ttagaaacca tccctctata tttggtaaaa     3480

gacattcaaa aagatcaaga tgtattaaag agttacttaa cagatctgct agggaaaaaa     3540

gaatttaaga ttttggttcc taaaataaaa atcaactccc tcttaaaaat taacggtttc     3600

ccttgtcata taacagggaa aaccaatgat tctttcttac tgcgtccggc tgttcagttt     3660

tgctgttcaa ataatgaagt tctttatttt aaaaaaatta taagattcag tgaaataaga     3720

agtcaaagag aaaagatagg aaaaacaatt tctccttatg aagacttatc ctttagatct     3780

tatatcaaag aaaatttatg gaaaaagaca aaaaatgatg aaataggaga aaaggagttt     3840

tatgaccttc ttcaaaagaa gaatttggaa atctatgata tgcttttaac aaaacataag     3900

gatactattt ataaaaaaag acctaactct gcaactattg atatcttagt caaaggaaaa     3960

gaaaagttta aatctttaat aatcgaaaat cagtttgaag ttattttaga gattttaaaa     4020

ctgttttctg ccactagaaa tgtatcagac ttacaacata taggcggaag caaatattca     4080

ggagttgcaa agataggaaa taaaatatct agtcttgata actgtatttt aatttaccaa     4140

tcaataacag gtatttttga aaaaaggatt gatttgttaa aggtatga                  4188


<210> 26
<211> 4188
<212> DNA
<213> Treponema denticola

<400> 26
atgaagaagg agatcaagga ctacttcctg ggcctggacg tgggcaccgg cagcgtgggc       60

tgggccgtga ccgacaccga ctacaagctg ctgaaggcca accgcaagga cctgtggggc      120

atgcgctgct tcgagactgc tgagaccgcc gaggtgcgcc ggctgcaccg cggtgctcgc      180

cggcgcatcg agcgccgcaa gaagcgcatc aagctgctgc aggagctgtt cagccaggag      240

atcgccaaga ccgacgaggg cttcttccag cgcatgaagg agagcccctt ctacgccgag      300

gacaagacca tcctgcagga gaacaccctg ttcaacgaca aggacttcgc cgacaagacc      360

taccacaagg cctaccccac catcaaccac ctgatcaagg cctggatcga gaacaaggtg      420

aagcccgacc ctcgcctgct gtacctggcc tgccacaaca tcatcaagaa gcgcggccac      480

ttcctgttcg agggcgactt cgacagcgag aaccagttcg acaccagcat ccaggccctg      540

ttcgagtacc tgcgcgagga catggaggtg gacatcgacg ccgacagcca gaaggtgaag      600

gagatcctga aggacagcag cctgaagaac agcgagaagc agagccgcct gaacaagatc      660

ctgggcctga agcccagcga caagcagaag aaggccatca ccaacctgat cagcggcaac      720

aagatcaact tcgccgacct gtacgacaac cccgacctga aggacgccga gaagaacagc      780

atcagcttca gcaaggacga cttcgacgcc ctgagcgacg acctggccag catcctgggc      840

gacagcttcg agctgctgct gaaggccaag gccgtgtaca actgcagcgt gctgagcaag      900

gtgatcggcg acgagcagta cctgagcttc gccaaggtga agatctacga gaagcacaag      960

accgacctta ccaagctgaa gaacgtgatc aagaagcact tccccaagga ctacaagaag     1020

gtgttcggct acaacaagaa cgagaagaac aacaacaact acagcggcta cgtgggcgtg     1080

tgcaagacca agagcaagaa gctgatcatc aacaacagcg tgaaccagga ggacttctac     1140

aagttcctga agaccatcct gagcgccaag agcgagatca aggaggtgaa cgacatcctg     1200

accgagatcg agaccggcac cttcctgccc aagcagatca gcaagagcaa cgccgagatc     1260

ccctaccagc tgcgcaagat ggagctggag aagatcctga gcaacgccga gaagcacttc     1320

agcttcctga agcagaagga cgagaagggc ctgagccaca gcgagaagat catcatgctg     1380

ctgaccttca agatccccta ctacatcggc cccatcaacg acaaccacaa gaagttcttc     1440

cccgaccgct gctgggtggt gaagaaggag aagagcccca gcggcaagac caccccctgg     1500

aacttcttcg accacatcga caaggagaag accgccgagg ccttcatcac cagccgcacc     1560

aacttctgca catacctggt gggcgagagc gtgctgccca agagcagcct gctgtacagc     1620

gagtacaccg tgctgaacga gatcaacaac ctgcagatca tcatcgacgg caagaacatc     1680

tgcgacatca agctgaagca gaagatctac gaggacctgt tcaagaagta caagaagatc     1740

acccagaagc agatcagcac cttcatcaag cacgagggca tctgcaacaa gaccgacgag     1800

gtgatcatcc tgggcatcga caaggagtgc accagcagcc tgaagagcta catcgagctg     1860

aagaacatct tcggcaagca ggtggacgag atcagcacca agaacatgct ggaggagatc     1920

atccgctggg ccaccatcta cgacgagggc gagggcaaga ccatcctgaa gaccaagatc     1980

aaggccgagt acggcaagta ctgcagcgac gagcagatca agaagatcct gaacctgaag     2040

ttcagcggct ggggccgcct gagccgcaag ttcctggaga ccgtgaccag cgagatgccc     2100

ggcttcagcg agcccgtgaa catcatcacc gccatgcgcg agacccagaa caacctgatg     2160

gagctgctga gcagcgagtt caccttcacc gagaacatca agaagatcaa cagcggcttc     2220

gaggacgccg agaagcagtt cagctacgac ggcctggtga agcccctgtt cctgagcccc     2280

agcgtgaaga agatgctgtg gcagaccctg aagctggtga aggagatcag ccacatcacc     2340

caggctcctc ctaagaagat cttcatcgag atggccaagg gcgccgagct ggagcctgct     2400

cgcaccaaga cccgcctgaa gatcctgcag gacctgtaca acaactgcaa gaacgacgcc     2460

gacgcattca gcagcgagat caaggacctg agcggcaaga tcgagaacga ggacaacctg     2520

cgcctgcgca gcgacaagct gtacctgtac tacacccagc tgggcaagtg catgtactgc     2580

ggcaagccca tcgagatcgg ccacgtgttc gacaccagca actacgacat cgaccacatc     2640

tacccccaga gcaagatcaa ggacgacagc atcagcaacc gcgtgctggt gtgcagcagc     2700

tgcaacaaga acaaggagga caagtaccct ctgaagagcg agatccagag caagcagcgc     2760

ggcttctgga acttcctgca gcgcaacaac ttcatcagcc tggagaagct gaaccgcctg     2820

acccgcgcca cccccatcag cgacgacgag accgccaagt tcatcgcccg ccagctggtg     2880

gagactcgcc aagctaccaa ggtggccgcc aaggtgctgg agaagatgtt ccccgagacc     2940

aagatcgtgt acagcaaggc cgagaccgtg agcatgttcc gcaacaagtt cgacatcgtg     3000

aagtgccgcg agatcaacga cttccaccac gcccacgacg cctacctgaa catcgtggtg     3060

ggcaacgtgt acaacaccaa gttcaccaac aacccctgga atttcattaa ggagaagcgc     3120

gacaacccca agatcgccga cacctacaac tactacaagg tgttcgacta cgacgtgaag     3180

cgcaacaaca tcaccgcctg ggagaagggc aagaccatca tcaccgtgaa ggacatgctg     3240

aagcgcaaca cccccatcta cacccgccag gccgcctgca agaagggcga gctgttcaac     3300

cagaccatca tgaagaaggg cctgggccag caccccctga agaaggaggg ccccttcagc     3360

aacatcagca agtacggcgg ctacaacaag gtgagcgccg cctactacac cctgatcgag     3420

tacgaggaga agggcaacaa gatccgcagc ctggagacca tccccctgta cctggtgaag     3480

gacatccaga aggaccagga cgtgctgaag agctacctga ccgacctgct gggcaagaag     3540

gagttcaaga tcctggtgcc caagatcaag atcaacagcc tgctgaagat caacggcttc     3600

ccctgccaca tcaccggcaa gaccaacgac agcttcctgc tgcgccccgc cgtgcagttc     3660

tgctgcagca acaacgaggt gctgtacttc aagaagatca tccgcttcag cgagatccgc     3720

agccagcgcg agaagatcgg caagaccatc agcccctacg aggacctgag cttccgcagc     3780

tacatcaagg agaacctgtg gaagaagacc aagaacgacg agatcggcga gaaggagttc     3840

tacgacctgc tgcagaagaa gaacctggag atctacgaca tgctgctgac caagcacaag     3900

gacaccatct acaagaagcg ccccaacagc gccaccatcg acatcctggt gaagggcaag     3960

gagaagttca agagcctgat catcgagaac cagttcgagg tgatcctgga gatcctgaag     4020

ctgttcagcg ccacccgcaa cgtgagcgac ctgcagcaca tcggcggcag caagtacagc     4080

ggcgtggcca agatcggcaa caagatcagc agcctggaca actgcatcct gatctaccag     4140

agcatcaccg gcatcttcga gaagcgcatc gacctgctga aggtgtaa                  4188


<210> 27
<211> 4188
<212> DNA
<213> Treponema denticola

<400> 27
atgaagaagg agatcaagga ctacttcctg ggcctggccg tgggcaccgg cagcgtgggc       60

tgggccgtga ccgacaccga ctacaagctg ctgaaggcca accgcaagga cctgtggggc      120

atgcgctgct tcgagactgc tgagaccgcc gaggtgcgcc ggctgcaccg cggtgctcgc      180

cggcgcatcg agcgccgcaa gaagcgcatc aagctgctgc aggagctgtt cagccaggag      240

atcgccaaga ccgacgaggg cttcttccag cgcatgaagg agagcccctt ctacgccgag      300

gacaagacca tcctgcagga gaacaccctg ttcaacgaca aggacttcgc cgacaagacc      360

taccacaagg cctaccccac catcaaccac ctgatcaagg cctggatcga gaacaaggtg      420

aagcccgacc ctcgcctgct gtacctggcc tgccacaaca tcatcaagaa gcgcggccac      480

ttcctgttcg agggcgactt cgacagcgag aaccagttcg acaccagcat ccaggccctg      540

ttcgagtacc tgcgcgagga catggaggtg gacatcgacg ccgacagcca gaaggtgaag      600

gagatcctga aggacagcag cctgaagaac agcgagaagc agagccgcct gaacaagatc      660

ctgggcctga agcccagcga caagcagaag aaggccatca ccaacctgat cagcggcaac      720

aagatcaact tcgccgacct gtacgacaac cccgacctga aggacgccga gaagaacagc      780

atcagcttca gcaaggacga cttcgacgcc ctgagcgacg acctggccag catcctgggc      840

gacagcttcg agctgctgct gaaggccaag gccgtgtaca actgcagcgt gctgagcaag      900

gtgatcggcg acgagcagta cctgagcttc gccaaggtga agatctacga gaagcacaag      960

accgacctta ccaagctgaa gaacgtgatc aagaagcact tccccaagga ctacaagaag     1020

gtgttcggct acaacaagaa cgagaagaac aacaacaact acagcggcta cgtgggcgtg     1080

tgcaagacca agagcaagaa gctgatcatc aacaacagcg tgaaccagga ggacttctac     1140

aagttcctga agaccatcct gagcgccaag agcgagatca aggaggtgaa cgacatcctg     1200

accgagatcg agaccggcac cttcctgccc aagcagatca gcaagagcaa cgccgagatc     1260

ccctaccagc tgcgcaagat ggagctggag aagatcctga gcaacgccga gaagcacttc     1320

agcttcctga agcagaagga cgagaagggc ctgagccaca gcgagaagat catcatgctg     1380

ctgaccttca agatccccta ctacatcggc cccatcaacg acaaccacaa gaagttcttc     1440

cccgaccgct gctgggtggt gaagaaggag aagagcccca gcggcaagac caccccctgg     1500

aacttcttcg accacatcga caaggagaag accgccgagg ccttcatcac cagccgcacc     1560

aacttctgca catacctggt gggcgagagc gtgctgccca agagcagcct gctgtacagc     1620

gagtacaccg tgctgaacga gatcaacaac ctgcagatca tcatcgacgg caagaacatc     1680

tgcgacatca agctgaagca gaagatctac gaggacctgt tcaagaagta caagaagatc     1740

acccagaagc agatcagcac cttcatcaag cacgagggca tctgcaacaa gaccgacgag     1800

gtgatcatcc tgggcatcga caaggagtgc accagcagcc tgaagagcta catcgagctg     1860

aagaacatct tcggcaagca ggtggacgag atcagcacca agaacatgct ggaggagatc     1920

atccgctggg ccaccatcta cgacgagggc gagggcaaga ccatcctgaa gaccaagatc     1980

aaggccgagt acggcaagta ctgcagcgac gagcagatca agaagatcct gaacctgaag     2040

ttcagcggct ggggccgcct gagccgcaag ttcctggaga ccgtgaccag cgagatgccc     2100

ggcttcagcg agcccgtgaa catcatcacc gccatgcgcg agacccagaa caacctgatg     2160

gagctgctga gcagcgagtt caccttcacc gagaacatca agaagatcaa cagcggcttc     2220

gaggacgccg agaagcagtt cagctacgac ggcctggtga agcccctgtt cctgagcccc     2280

agcgtgaaga agatgctgtg gcagaccctg aagctggtga aggagatcag ccacatcacc     2340

caggctcctc ctaagaagat cttcatcgag atggccaagg gcgccgagct ggagcctgct     2400

cgcaccaaga cccgcctgaa gatcctgcag gacctgtaca acaactgcaa gaacgacgcc     2460

gacgcattca gcagcgagat caaggacctg agcggcaaga tcgagaacga ggacaacctg     2520

cgcctgcgca gcgacaagct gtacctgtac tacacccagc tgggcaagtg catgtactgc     2580

ggcaagccca tcgagatcgg ccacgtgttc gacaccagca actacgacat cgctgctatc     2640

tacccccaga gcaagatcaa ggacgacagc atcagcaacc gcgtgctggt gtgcagcagc     2700

tgcgccaaga acaaggagga caagtaccct ctgaagagcg agatccagag caagcagcgc     2760

ggcttctgga acttcctgca gcgcaacaac ttcatcagcc tggagaagct gaaccgcctg     2820

acccgcgcca cccccatcag cgacgacgag accgccaagt tcatcgcccg ccagctggtg     2880

gagactcgcc aagctaccaa ggtggccgcc aaggtgctgg agaagatgtt ccccgagacc     2940

aagatcgtgt acagcaaggc cgagaccgtg agcatgttcc gcaacaagtt cgacatcgtg     3000

aagtgccgcg agatcaacga cttccaccac gcccacgacg cctacctgaa catcgtggtg     3060

ggcaacgtgt acaacaccaa gttcaccaac aacccctgga atttcattaa ggagaagcgc     3120

gacaacccca agatcgccga cacctacaac tactacaagg tgttcgacta cgacgtgaag     3180

cgcaacaaca tcaccgcctg ggagaagggc aagaccatca tcaccgtgaa ggacatgctg     3240

aagcgcaaca cccccatcta cacccgccag gccgcctgca agaagggcga gctgttcaac     3300

cagaccatca tgaagaaggg cctgggccag caccccctga agaaggaggg ccccttcagc     3360

aacatcagca agtacggcgg ctacaacaag gtgagcgccg cctactacac cctgatcgag     3420

tacgaggaga agggcaacaa gatccgcagc ctggagacca tccccctgta cctggtgaag     3480

gacatccaga aggaccagga cgtgctgaag agctacctga ccgacctgct gggcaagaag     3540

gagttcaaga tcctggtgcc caagatcaag atcaacagcc tgctgaagat caacggcttc     3600

ccctgccaca tcaccggcaa gaccaacgac agcttcctgc tgcgccccgc cgtgcagttc     3660

tgctgcagca acaacgaggt gctgtacttc aagaagatca tccgcttcag cgagatccgc     3720

agccagcgcg agaagatcgg caagaccatc agcccctacg aggacctgag cttccgcagc     3780

tacatcaagg agaacctgtg gaagaagacc aagaacgacg agatcggcga gaaggagttc     3840

tacgacctgc tgcagaagaa gaacctggag atctacgaca tgctgctgac caagcacaag     3900

gacaccatct acaagaagcg ccccaacagc gccaccatcg acatcctggt gaagggcaag     3960

gagaagttca agagcctgat catcgagaac cagttcgagg tgatcctgga gatcctgaag     4020

ctgttcagcg ccacccgcaa cgtgagcgac ctgcagcaca tcggcggcag caagtacagc     4080

ggcgtggcca agatcggcaa caagatcagc agcctggaca actgcatcct gatctaccag     4140

agcatcaccg gcatcttcga gaagcgcatc gacctgctga aggtgtaa                  4188


<210> 28
<211> 1053
<212> PRT
<213> Streptococcus aureas

<400> 28
Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210> 29
<211> 3162
<212> DNA
<213> Streptococcus aureas

<400> 29
atgaaaagga attatatctt aggattagat atcggaatta catcagtggg ttatggaatt       60

attgattatg aaactagaga tgtcatagat gcgggcgtac gtttatttaa agaggctaat      120

gttgaaaata atgaaggacg acgatcaaaa agaggtgcca gaaggcttaa gaggcgtcgt      180

agacatagaa tacaaagagt aaagaaactt ttatttgatt acaatttgtt gacagatcat      240

agtgagctaa gtggaatcaa tccttacgag gcgcgcgtaa agggattaag tcaaaaatta      300

agtgaagagg aattttctgc ggcattgcta catttagcaa agcgtagagg tgtacataat      360

gttaatgaag tggaagaaga tacaggtaat gaattatcca ctaaagaaca aatttcaaga      420

aatagtaaag cgttagaaga gaagtatgtt gcagaattac agttggaacg tttgaaaaaa      480

gacggtgaag tgagaggttc gattaaccgt ttcaaaacat ctgactatgt aaaagaagca      540

aagcagttat taaaagtaca aaaagcatat catcaacttg atcaatcatt tatagacact      600

tatattgatt tattggaaac aagaagaaca tattatgagg gaccaggtga aggtagccca      660

tttggatgga aagatattaa agaatggtat gaaatgttaa tgggacattg tacgtatttc      720

ccagaagaat tacgtagtgt gaaatatgcc tataatgctg atttatataa tgcgctgaat      780

gatttgaaca acttggttat tacacgagat gagaatgaga agctagagta ttatgaaaaa      840

ttccaaatta tcgagaatgt ctttaaacaa aagaaaaagc cgacgcttaa acaaattgcg      900

aaggaaatct tggtgaatga agaagacatc aaaggctatc gtgtcacaag tacaggtaaa      960

ccagaattta caaacttgaa agtttatcac gatatcaaag atattacagc aagaaaagaa     1020

attatcgaga atgcagagct actcgatcaa atagctaaaa tattaactat ttaccagtca     1080

tcagaagata tacaagaaga attaacaaac ctaaattcag aattgacaca agaagagatt     1140

gaacaaattt caaacttgaa aggttataca ggaactcata acctttcact aaaggcaata     1200

aatttaatat tagacgaatt gtggcatacg aacgataatc aaatagctat tttcaatcgt     1260

ttgaaacttg tacctaaaaa ggtagattta agccaacaaa aagaaattcc tactacttta     1320

gttgatgatt ttatactgtc tccagtagtg aaacgttcat ttatacaatc tattaaagtt     1380

attaacgcta ttattaaaaa atacggtttg ccaaatgata ttattattga acttgcgaga     1440

gaaaagaatt ctaaagatgc acaaaaaatg attaatgaaa tgcagaagag aaatcgtcaa     1500

acgaatgaac gtattgagga aattataaga acgacaggta aagaaaatgc taaatattta     1560

attgaaaaaa ttaagctgca cgatatgcaa gaagggaaat gtttatactc gttagaagca     1620

atccctctag aagatttact taataatcca ttcaattacg aagtagacca tatcattcca     1680

cgttctgttt ctttcgataa ctctttcaat aataaagtgt tggtgaaaca agaagaaaat     1740

agtaaaaaag gtaatagaac gccatttcaa tatttaagtt cttcagattc taaaataagt     1800

tatgagacat tcaaaaagca tattttaaat cttgctaaag gcaaaggtag aatctctaag     1860

acgaaaaaag aatatttgtt agaagaacga gatatcaatc gcttcagtgt ccaaaaagat     1920

tttattaacc gtaacttagt agatacacgc tatgcgacaa gagggttaat gaacttatta     1980

agatcttatt ttagagtgaa taacttagat gtcaaagtga aatcgattaa tggcggattc     2040

acaagtttct taagaaggaa atggaagttc aaaaaagaaa gaaataaggg ctacaaacac     2100

catgctgaag atgcactgat tattgcgaac gctgatttta ttttcaaaga atggaaaaaa     2160

ctagataaag ctaaaaaagt gatggaaaat caaatgtttg aagaaaagca agctgaaagt     2220

atgcctgaaa ttgagactga gcaagagtat aaagaaattt ttataacgcc tcatcaaatt     2280

aaacatatta aggattttaa agattataaa tattcacata gagttgataa aaagccgaat     2340

agagagttaa taaatgatac attatattct acgagaaaag atgacaaggg taatacatta     2400

atcgttaata acttaaatgg tttatacgat aaagataatg ataaattgaa aaaattaatt     2460

aataaatcac ctgaaaaatt attgatgtat catcatgatc cacaaacata tcaaaaatta     2520

aaattgatca tggaacaata tggcgatgag aaaaatccgc tttataaata ttatgaagaa     2580

acaggcaatt acttaacaaa atatagtaaa aaagataacg gaccagtcat caaaaaaatt     2640

aaatattatg gtaacaagct aaatgcgcat ttagatatta cggatgatta tccaaatagc     2700

agaaataaag tagtaaaact ttcattaaaa ccatatcgct ttgatgttta tttagataat     2760

ggggtatata aatttgtgac agttaaaaat ttagatgtta tcaaaaaaga aaactactat     2820

gaagttaatt caaagtgtta tgaagaagca aaaaaactga agaaaattag taatcaagca     2880

gaatttatcg caagttttta caataatgac ttgattaaga ttaacggaga attatataga     2940

gtcataggtg taaataatga tctacttaac agaattgaag taaatatgat agacatcaca     3000

tatagagaat atttagagaa catgaatgat aaaagaccac ctagaataat taaaacaata     3060

gcaagcaaaa cacaatctat taaaaagtat tctacagata ttctaggcaa tctttatgaa     3120

gtgaagagta aaaagcatcc tcaaatcata aagaaaggat ga                        3162


<210> 30
<211> 1629
<212> PRT
<213> Francisella tularensis

<400> 30
Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210> 31
<211> 4890
<212> DNA
<213> Francisella tularensis

<400> 31
atgaatttca aaatattgcc aatagcaata gatttaggtg ttaaaaatac tggtgtcttt       60

agcgcatttt atcaaaaagg aacttctctt gagagattgg ataataaaaa tggcaaagta      120

tatgaactat caaaagattc ttatacttta ttgatgaata atagaacagc aagaagacat      180

caaagaagag ggatagatag aaagcagcta gtcaaaaggc tctttaagct tatttggaca      240

gagcagctaa atttagagtg ggataaagac actcaacaag caattagctt tttatttaat      300

cgtagaggtt ttagttttat tactgatggt tattcgcctg aatatttaaa tattgttcca      360

gagcaagtaa aagcgatact tatggatata tttgatgatt acaacggtga agatgattta      420

gacagttatt taaaattagc tactgagcaa gaaagcaaaa tttctgaaat ttataacaag      480

ctaatgcaaa aaatattaga gtttaaatta atgaaattat gtactgatat taaggatgat      540

aaagtaagta ctaaaacgct taaagaaatc acaagctatg aatttgagtt attagctgat      600

tatttagcaa actatagcga gagtttaaaa acacaaaaat ttagttatac agataaacaa      660

ggtaatttaa aagagctaag ctactatcat catgataaat ataatattca agaatttcta      720

aagcgacatg ctactataaa tgatcgaatt ttagatactc ttttaactga tgatttagat      780

atttggaatt ttaattttga gaaatttgat tttgataaga atgaagaaaa gcttcagaat      840

caggaagata aagatcatat acaagcgcat ttacatcatt ttgtttttgc agtaaataaa      900

ataaaaagtg aaatggcaag tggtggtcgt catcgtagcc aatattttca agagataaca      960

aatgtgctag atgaaaataa tcatcaagag ggatatctca agaatttctg tgaaaatttg     1020

cataataaaa aatattcaaa tttaagtgtt aaaaatttag ttaatctaat tggtaaccta     1080

agtaatttag agctaaaacc gctaagaaaa tattttaatg acaaaattca cgcaaaagct     1140

gatcattggg atgagcaaaa gtttacagaa acttattgcc actggatatt aggagagtgg     1200

cgagtaggtg tcaaagatca agataagaaa gatggcgcta aatatagtta taaagatctg     1260

tgtaatgaat taaaacaaaa agttactaag gctggtttgg tagatttttt attagagtta     1320

gatccatgta gaactatacc accatatctg gataacaata accgtaaacc accaaaatgt     1380

caaagtttga ttttaaatcc gaagttttta gataatcaat atccaaactg gcaacaatat     1440

ttacaagaat taaagaaact acaaagtatt caaaattatt tagacagttt tgaaactgat     1500

ttaaaagtct taaagtcaag taaagatcaa ccatattttg ttgaatacaa gagttcaaat     1560

cagcaaatag caagtggtca aagagattat aaagatttag atgctcgaat attacagttt     1620

atatttgata gggtaaaagc tagtgatgag ttgcttttga atgagattta ttttcaggct     1680

aaaaaactta aacaaaaagc tagctctgag ttagaaaaac tcgagtcgag caaaaagcta     1740

gatgaagtta tagcaaatag tcaactatca cagatactaa agtctcaaca tacaaatggt     1800

atttttgaac agggtacttt tttgcatttg gtttgtaaat attataaaca aagacaaaga     1860

gcgagagact ctaggctata tattatgcct gaatatcgtt atgataaaaa actacataaa     1920

tataacaata caggcaggtt tgatgatgat aatcagctgc taacatattg taatcataag     1980

ccaagacaaa aaagatacca attgttaaat gatttagctg gggtgttgca ggtatcacct     2040

aattttttga aagataaaat tggttctgat gatgatctat ttattagcaa atggttggta     2100

gagcatatta gaggatttaa aaaagcttgt gaagatagtt taaaaataca aaaagacaat     2160

agaggattat taaatcataa aataaatata gctaggaata caaaaggcaa atgtgaaaaa     2220

gaaatattta atttaatatg taaaatagaa ggttcagaag ataaaaaagg taattacaag     2280

catggtttag cttacgaatt aggagtactt ttatttggtg aacctaatga agctagtaaa     2340

cctgagttcg atagaaaaat taaaaaattt aactcaatat acagttttgc acagattcaa     2400

caaattgctt ttgcagagcg taaaggcaat gctaacactt gtgcagtttg tagtgctgat     2460

aatgctcata gaatgcaaca aattaagatc actgagcctg tagaggacaa taaagataag     2520

ataatcttaa gtgccaaagc tcagagacta ccagcgattc caactagaat agttgacggt     2580

gcggttaaga aaatggcaac tatattagct aaaaatatag ttgatgataa ttggcagaat     2640

atcaaacaag ttttatcagc aaaacatcag ttacatatac ctattatcac agaatcaaat     2700

gcttttgagt ttgaaccagc attagctgat gtaaaaggta agagcctaaa agataggaga     2760

aaaaaagcat tagagagaat aagtcctgaa aatatattca aggataaaaa caatagaata     2820

aaagaatttg ctaaaggtat atcagcatat agtggtgcta atttaactga tggcgatttt     2880

gatggtgcaa aagaagaatt agatcatata atacctcgtt cacataaaaa atacggtact     2940

ctaaatgatg aagcaaatct aatttgtgta actcgtggtg ataataaaaa taaaggtaat     3000

agaattttct gcctacgtga tcttgcagat aactataaac taaaacagtt tgagacaact     3060

gatgatttag aaattgaaaa gaagatagct gatacaatct gggatgctaa caagaaagat     3120

tttaaatttg gtaattatcg tagttttatt aacctaacac cacaagagca gaaagcattt     3180

cgtcacgcgc tatttctggc tgatgaaaat cctatcaaac aagcagtcat aagagcgata     3240

aataatcgta atcgtacatt tgtaaatggc actcaacgct attttgcaga agtactggca     3300

aacaatatct atctaagggc taaaaaagaa aatctaaata cagataaaat ttcatttgat     3360

tattttggta ttccaactat aggtaatggt agaggtattg ctgaaatccg tcaactttat     3420

gaaaaagttg atagtgatat acaagcttat gcaaaaggtg ataaacctca agctagctac     3480

tctcacctaa tagatgcgat gctggctttt tgtattgctg ctgatgaaca cagaaatgat     3540

ggaagtatag gtctagaaat cgataaaaat tatagtttat atccattaga taaaaataca     3600

ggagaagtct ttaccaaaga tatttttagt caaattaaaa ttactgataa tgagtttagc     3660

gataaaaaat tagtaagaaa aaaagctata gagggcttta acacgcatag acaaatgact     3720

agagatggca tttatgcaga aaattaccta ccaatactaa tccataaaga actaaatgaa     3780

gttagaaaag gctatacttg gaaaaatagt gaagaaataa aaatattcaa aggtaaaaag     3840

tacgatatac aacaattgaa taaccttgtg tattgtctaa aatttgtaga taaacctata     3900

tctatagata tacaaattag taccttagaa gagttaagaa atatattaac aacaaataat     3960

atagctgcta cagcagaata ctattatata aatctaaaaa cccaaaaatt acatgagtat     4020

tatatcgaaa actataatac tgccttaggt tataaaaaat acagtaaaga aatggagttt     4080

ttgagaagct tagcttatcg tagcgaaagg gtaaaaatta aatcaataga tgatgtaaag     4140

caggttttgg ataaggatag taactttatc atcggtaaga ttactttacc atttaaaaaa     4200

gagtggcaaa gactatatcg tgagtggcaa aatacaacta tcaaagatga ttatgagttt     4260

ttaaaatcat tctttaatgt taaaagtatt actaagttgc ataaaaaagt tagaaaagat     4320

ttctctttac ctatttctac aaatgaaggt aaattcctgg tcaaaagaaa aacatgggat     4380

aacaatttta tctatcagat attaaatgat tctgattcta gagcagacgg aacaaagcca     4440

tttattccag cttttgacat ttctaaaaat gaaatagtcg aagccataat tgattcattt     4500

acatcaaaaa atattttttg gctgcctaaa aatatagaat tacaaaaggt ggataataaa     4560

aacatttttg ctatagatac tagtaaatgg ttcgaagtag aaacacctag tgatcttaga     4620

gacattggaa tagcaacaat tcaatacaag atagataata attctcgccc taaagtcaga     4680

gttaaacttg attatgttat cgatgatgat agtaagataa attattttat gaatcattct     4740

ttattaaaat caagatatcc tgacaaagtt ttagaaattt taaaacaatc aactattata     4800

gaatttgaaa gttcaggttt taataaaact atcaaagaaa tgcttggtat gaaattagca     4860

ggtatttata atgaaacatc taataattag                                      4890


<210> 32
<211> 3903
<212> DNA
<213> Francisella tularensis


<220>
<223> Francisella tularensis subsp. novicida (strain U112)

<400> 32
atgtcaattt atcaagaatt tgttaataaa tatagtttaa gtaaaactct aagatttgag       60

ttaatcccac agggtaaaac acttgaaaac ataaaagcaa gaggtttgat tttagatgat      120

gagaaaagag ctaaagacta caaaaaggct aaacaaataa ttgataaata tcatcagttt      180

tttatagagg agatattaag ttcggtttgt attagcgaag atttattaca aaactattct      240

gatgtttatt ttaaacttaa aaagagtgat gatgataatc tacaaaaaga ttttaaaagt      300

gcaaaagata cgataaagaa acaaatatct gaatatataa aggactcaga gaaatttaag      360

aatttgttta atcaaaacct tatcgatgct aaaaaagggc aagagtcaga tttaattcta      420

tggctaaagc aatctaagga taatggtata gaactattta aagccaatag tgatatcaca      480

gatatagatg aggcgttaga aataatcaaa tcttttaaag gttggacaac ttattttaag      540

ggttttcatg aaaatagaaa aaatgtttat agtagcaatg atattcctac atctattatt      600

tataggatag tagatgataa tttgcctaaa tttctagaaa ataaagctaa gtatgagagt      660

ttaaaagaca aagctccaga agctataaac tatgaacaaa ttaaaaaaga tttggcagaa      720

gagctaacct ttgatattga ctacaaaaca tctgaagtta atcaaagagt tttttcactt      780

gatgaagttt ttgagatagc aaactttaat aattatctaa atcaaagtgg tattactaaa      840

tttaatacta ttattggtgg taaatttgta aatggtgaaa atacaaagag aaaaggtata      900

aatgaatata taaatctata ctcacagcaa ataaatgata aaacactcaa aaaatataaa      960

atgagtgttt tatttaagca aattttaagt gatacagaat ctaaatcttt tgtaattgat     1020

aagttagaag atgatagtga tgtagttaca acgatgcaaa gtttttatga gcaaatagca     1080

gcttttaaaa cagtagaaga aaaatctatt aaagaaacac tatctttatt atttgatgat     1140

ttaaaagctc aaaaacttga tttgagtaaa atttatttta aaaatgataa atctcttact     1200

gatctatcac aacaagtttt tgatgattat agtgttattg gtacagcggt actagaatat     1260

ataactcaac aaatagcacc taaaaatctt gataacccta gtaagaaaga gcaagaatta     1320

atagccaaaa aaactgaaaa agcaaaatac ttatctctag aaactataaa gcttgcctta     1380

gaagaattta ataagcatag agatatagat aaacagtgta ggtttgaaga aatacttgca     1440

aactttgcgg ctattccgat gatatttgat gaaatagctc aaaacaaaga caatttggca     1500

cagatatcta tcaaatatca aaatcaaggt aaaaaagacc tacttcaagc tagtgcggaa     1560

gatgatgtta aagctatcaa ggatctttta gatcaaacta ataatctctt acataaacta     1620

aaaatatttc atattagtca gtcagaagat aaggcaaata ttttagacaa ggatgagcat     1680

ttttatctag tatttgagga gtgctacttt gagctagcga atatagtgcc tctttataac     1740

aaaattagaa actatataac tcaaaagcca tatagtgatg agaaatttaa gctcaatttt     1800

gagaactcga ctttggctaa tggttgggat aaaaataaag agcctgacaa tacggcaatt     1860

ttatttatca aagatgataa atattatctg ggtgtgatga ataagaaaaa taacaaaata     1920

tttgatgata aagctatcaa agaaaataaa ggcgagggtt ataaaaaaat tgtttataaa     1980

cttttacctg gcgcaaataa aatgttacct aaggttttct tttctgctaa atctataaaa     2040

ttttataatc ctagtgaaga tatacttaga ataagaaatc attccacaca tacaaaaaat     2100

ggtagtcctc aaaaaggata tgaaaaattt gagtttaata ttgaagattg ccgaaaattt     2160

atagattttt ataaacagtc tataagtaag catccggagt ggaaagattt tggatttaga     2220

ttttctgata ctcaaagata taattctata gatgaatttt atagagaagt tgaaaatcaa     2280

ggctacaaac taacttttga aaatatatca gagagctata ttgatagcgt agttaatcag     2340

ggtaaattgt acctattcca aatctataat aaagattttt cagcttatag caaagggcga     2400

ccaaatctac atactttata ttggaaagcg ctgtttgatg agagaaatct tcaagatgtg     2460

gtttataagc taaatggtga ggcagagctt ttttatcgta aacaatcaat acctaaaaaa     2520

atcactcacc cagctaaaga ggcaatagct aataaaaaca aagataatcc taaaaaagag     2580

agtgtttttg aatatgattt aatcaaagat aaacgcttta ctgaagataa gtttttcttt     2640

cactgtccta ttacaatcaa ttttaaatct agtggagcta ataagtttaa tgatgaaatc     2700

aatttattgc taaaagaaaa agcaaatgat gttcatatat taagtataga tagaggtgaa     2760

agacatttag cttactatac tttggtagat ggtaaaggca atatcatcaa acaagatact     2820

ttcaacatca ttggtaatga tagaatgaaa acaaactacc atgataagct tgctgcaata     2880

gagaaagata gggattcagc taggaaagac tggaaaaaga taaataacat caaagagatg     2940

aaagagggct atctatctca ggtagttcat gaaatagcta agctagttat agagtataat     3000

gctattgtgg tttttgagga tttaaatttt ggatttaaaa gagggcgttt caaggtagag     3060

aagcaggtct atcaaaagtt agaaaaaatg ctaattgaga aactaaacta tctagttttc     3120

aaagataatg agtttgataa aactggggga gtgcttagag cttatcagct aacagcacct     3180

tttgagactt ttaaaaagat gggtaaacaa acaggtatta tctactatgt accagctggt     3240

tttacttcaa aaatttgtcc tgtaactggt tttgtaaatc agttatatcc taagtatgaa     3300

agtgtcagca aatctcaaga gttctttagt aagtttgaca agatttgtta taaccttgat     3360

aagggctatt ttgagtttag ttttgattat aaaaactttg gtgacaaggc tgccaaaggc     3420

aagtggacta tagctagctt tgggagtaga ttgattaact ttagaaattc agataaaaat     3480

cataattggg atactcgaga agtttatcca actaaagagt tggagaaatt gctaaaagat     3540

tattctatcg aatatgggca tggcgaatgt atcaaagcag ctatttgcgg tgagagcgac     3600

aaaaagtttt ttgctaagct aactagtgtc ctaaatacta tcttacaaat gcgtaactca     3660

aaaacaggta ctgagttaga ttatctaatt tcaccagtag cagatgtaaa tggcaatttc     3720

tttgattcgc gacaggcgcc aaaaaatatg cctcaagatg ctgatgccaa tggtgcttat     3780

catattgggc taaaaggtct gatgctacta ggtaggatca aaaataatca agagggcaaa     3840

aaactcaatt tggttatcaa aaatgaagag tattttgagt tcgtgcagaa taggaataac     3900

taa                                                                   3903


<210> 33
<211> 1300
<212> PRT
<213> Francisella tularensis


<220>
<223> Francisella tularensis subsp. novicida (strain U112)

<400> 33
Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210> 34
<211> 3924
<212> DNA
<213> Acidaminococcus sp.


<220>
<223> Acidaminococcus sp. (strain BV3L6)

<400> 34
atgacccaat ttgaaggttt taccaattta taccaagttt cgaagaccct tcgttttgaa       60

ctgattcccc aaggaaaaac actcaaacat atccaggagc aagggttcat tgaggaggat      120

aaagctcgca atgaccatta caaagagtta aaaccaatca ttgaccgcat ctataagact      180

tatgctgatc aatgtctcca actggtacag cttgactggg agaatctatc tgcagccata      240

gactcctatc gtaaggaaaa aaccgaagaa acacgaaatg cgctgattga ggagcaagca      300

acatatagaa atgcgattca tgactacttt ataggtcgga cggataatct gacagatgcc      360

ataaataagc gccatgctga aatctataaa ggacttttta aagctgaact tttcaatgga      420

aaagttttaa agcaattagg gaccgtaacc acgacagaac atgaaaatgc tctactccgt      480

tcgtttgaca aatttacgac ctatttttcc ggcttttatg aaaaccgaaa aaatgtcttt      540

agcgctgaag atatcagcac ggcaattccc catcgaatcg tccaggacaa tttccctaaa      600

tttaaggaaa actgccatat ttttacaaga ttgataaccg cagttccttc tttgcgggag      660

cattttgaaa atgtcaaaaa ggccattgga atctttgtta gtacgtctat tgaagaagtc      720

ttttcctttc ccttttataa tcaacttcta acccaaacgc aaattgatct ttataatcaa      780

cttctcggcg gcatatctag ggaagcaggc acagaaaaaa tcaagggact taatgaagtt      840

ctcaatctgg ctatccaaaa aaatgatgaa acagcccata taatcgcgtc cctgccgcat      900

cgttttattc ctctttttaa acaaattctt tccgatcgaa atacgttatc ctttattttg      960

gaagaattca aaagcgatga ggaagtcatc caatccttct gcaaatataa aaccctcttg     1020

agaaacgaaa atgtactgga gactgcagaa gcccttttca atgaattaaa ttccattgat     1080

ttgactcata tctttatttc ccataaaaag ttagaaacca tctcttcagc gctttgtgac     1140

cattgggata ccttgcgcaa tgcactttac gaaagacgga tttctgaact cactggcaaa     1200

ataacaaaaa gtgccaaaga aaaagttcaa aggtcattaa aacatgagga tataaatctc     1260

caagaaatta tttctgctgc aggaaaagaa ctatcagaag cattcaaaca aaaaacaagt     1320

gaaattcttt cccatgccca tgctgcactt gaccagcctc ttcccacaac attaaaaaaa     1380

caggaagaaa aagaaatcct caaatcacag ctcgattcgc ttttaggcct ttatcatctt     1440

cttgattggt ttgctgtcga tgaaagcaat gaagtcgacc cagaattctc agcacggctg     1500

acaggcatta aactagaaat ggaaccaagc ctttcgtttt ataataaagc aagaaattat     1560

gcgacaaaaa agccctattc ggtggaaaaa tttaaattga attttcaaat gccaaccctt     1620

gcctctggtt gggatgtcaa taaagaaaaa aataatggag ctattttatt cgtaaaaaat     1680

ggtctctatt accttggtat catgcctaaa cagaaggggc gctataaagc cctgtctttt     1740

gagccgacag aaaaaacatc agaaggattc gataagatgt actatgacta cttcccagat     1800

gccgcaaaaa tgattcctaa gtgttccact cagctaaagg ctgtaaccgc tcattttcaa     1860

actcatacca cccccattct tctctcaaat aatttcattg aacctcttga aatcacaaaa     1920

gaaatttatg acctgaacaa tcctgaaaag gagcctaaaa agtttcaaac ggcttatgca     1980

aagaagacag gcgatcaaaa aggctataga gaagcgcttt gcaaatggat tgactttacg     2040

cgggattttc tctctaaata tacgaaaaca acttcaatcg atttatcttc actccgccct     2100

tcttcgcaat ataaagattt aggggaatat tacgccgaac tgaatccgct tctctatcat     2160

atctccttcc aacgaattgc tgaaaaggaa atcatggatg ctgtagaaac gggaaaattg     2220

tatctgttcc aaatctacaa taaggatttt gcgaagggcc atcacgggaa accaaatctc     2280

cacaccctgt attggacagg tctcttcagt cctgaaaacc ttgcgaaaac cagcatcaaa     2340

cttaatggtc aagcagaatt gttctatcga cctaaaagcc gcatgaagcg gatggcccat     2400

cgtcttgggg aaaaaatgct gaacaaaaaa ctaaaggacc agaagacacc gattccagat     2460

accctctacc aagaactgta cgattatgtc aaccaccggc taagccatga tctttccgat     2520

gaagcaaggg ccctgcttcc aaatgttatc accaaagaag tctcccatga aattataaag     2580

gatcggcggt ttacttccga taaatttttc ttccatgttc ccattacact gaattatcaa     2640

gcagccaata gtcccagtaa attcaaccag cgtgtcaatg cctaccttaa ggagcatccg     2700

gaaacgccca tcattggtat cgatcgtgga gaacgcaatc taatctatat taccgtcatt     2760

gacagtactg ggaaaatttt ggagcagcgt tccctgaata ccatccagca atttgactac     2820

caaaaaaaat tggacaacag ggaaaaagag cgtgttgccg cccgtcaagc ctggtccgtc     2880

gtcggaacga tcaaagacct taaacaaggc tacttgtcac aggtcatcca tgaaattgta     2940

gacctgatga ttcattacca agctgttgtc gtccttgaaa acctcaactt cggatttaaa     3000

tcaaaacgga caggcattgc cgaaaaagca gtctaccaac aatttgaaaa gatgctaata     3060

gataaactca actgtttggt tctcaaagat tatcctgctg agaaagtggg aggcgtctta     3120

aacccgtatc aacttacaga tcagttcacg agctttgcaa aaatgggcac gcaaagcggc     3180

ttccttttct atgtaccggc cccttatacc tcaaagattg atcccctgac tggttttgtc     3240

gatccctttg tatggaagac cattaaaaat catgaaagtc ggaagcattt cctagaagga     3300

tttgatttcc tgcattatga tgtcaaaaca ggtgatttta tcctccattt taaaatgaat     3360

cggaatctct ctttccagag agggcttcct ggcttcatgc cagcttggga tattgttttc     3420

gaaaagaatg aaacccaatt tgatgcaaaa gggacgccct tcattgcagg aaaacgaatt     3480

gttcctgtaa tcgaaaatca tcgttttacg ggtcgttaca gagacctcta tcccgctaat     3540

gaactcattg cccttctgga agaaaaaggc attgtcttta gagacggaag taatatatta     3600

cccaaacttt tagaaaatga tgattctcat gcaattgata cgatggtcgc cttgattcgc     3660

agtgtactcc aaatgagaaa cagcaatgcc gcaacggggg aagactacat caactctccc     3720

gttagggatc tgaacggggt gtgtttcgac agtcgattcc aaaatccaga atggccaatg     3780

gatgcggatg ccaacggagc ttatcatatt gccttaaaag ggcagcttct tctgaaccac     3840

ctcaaagaaa gcaaagatct gaaattacaa aacggcatca gcaaccaaga ttggctggcc     3900

tacattcagg aactgagaaa ctga                                            3924


<210> 35
<211> 1307
<212> PRT
<213> Acidaminococcus sp.


<220>
<223> Acidaminococcus sp. (strain BV3L6)

<400> 35
Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210> 36
<211> 3741
<212> DNA
<213> Lachnospiraceae bacterium


<220>
<223> Lachnospiraceae bacterium (strain ND2006)

<400> 36
atgcttaaga atgttggaat tgataggtta gatgttgaaa aagggagaaa aaatatgtct       60

aaattagaga agtttacaaa ttgttactct ttgtcaaaaa cacttcgttt taaggcgatt      120

cctgttggaa aaacccaaga aaatattgat aataaaagat tgcttgtcga ggatgaaaaa      180

cgtgcagaag attataaggg ggttaaaaaa ttacttgata ggtattattt atcatttatt      240

aatgatgttc ttcattccat taaactaaag aatttaaata attatatttc gttgtttaga      300

aagaaaactc ggacggaaaa agaaaacaaa gaattagaaa atttagagat aaatttacgt      360

aaagaaatcg ctaaggcttt taagggtaat gaaggttata aatctttatt taagaaggat      420

attatcgaga cgatattgcc tgaatttctt gatgataaag atgaaattgc tttggttaat      480

tcatttaatg gatttacaac ggcatttacc ggtttttttg ataataggga aaatatgttt      540

tcggaagaag ctaaatcaac ctcaattgct tttcgttgta ttaatgagaa tttaacaaga      600

tatatatcaa atatggatat atttgaaaaa gttgatgcaa ttttcgataa gcatgaagta      660

caggaaataa aagaaaaaat tctaaacagt gattatgatg ttgaagattt cttcgaagga      720

gaatttttta attttgttct tacgcaagaa ggtatcgatg tttataacgc tataattggt      780

ggctttgtga cagaatccgg agaaaaaata aaaggattaa atgaatatat taatttatat      840

aatcagaaaa ctaagcaaaa attaccgaag tttaagcctt tatataaaca ggttttatca      900

gatagagagt cactttcttt ttatggcgaa ggttatacat ctgatgagga agttttagaa      960

gtatttagaa atactcttaa taagaattca gaaatatttt cttcaattaa gaaattggaa     1020

aagttattta aaaacttcga tgaatattca agtgcaggaa ttttcgtaaa aaatggaccg     1080

gctatttcta caatttctaa ggatatattt ggagagtgga atgtaattag agacaaatgg     1140

aatgcggagt acgatgatat acatttaaaa aagaaggctg tagtaacaga aaaatatgaa     1200

gatgacaggc gtaaatcatt caaaaaaata ggaagttttt cattggagca gttgcaagaa     1260

tacgctgatg ctgatctatc tgtggtagag aagttaaaag aaatcattat ccaaaaagtg     1320

gatgagatat ataaagttta tggctcgtca gaaaaattgt tcgatgctga ttttgtacta     1380

gaaaaatcgt taaaaaagaa tgatgcagtt gtagcaataa tgaaagattt actagattct     1440

gtgaagtctt ttgaaaatta tataaaagcc ttttttggag agggaaaaga aacaaatcga     1500

gatgaatcat tttatggtga ttttgttttg gcatatgaca ttcttttgaa agtggatcat     1560

atttatgatg caatacgaaa ttatgtgaca caaaaaccgt attcgaaaga taagtttaaa     1620

ttatattttc aaaacccgca atttatgggg ggctgggata aggataaaga gacagactat     1680

agggcaacta tacttagata tggctcaaag tattacttgg cgattatgga taaaaaatat     1740

gctaagtgct tgcaaaaaat agataaggat gatgtaaatg gaaactatga aaaaataaat     1800

tataagttgc ttccaggacc taataagatg cttccaaagg tgttttttag taagaagtgg     1860

atggcttatt ataatccgtc ggaagatatt caaaaaatat ataaaaatgg aacatttaaa     1920

aaaggagata tgtttaattt aaatgattgt cataaattaa ttgatttctt taaggattca     1980

atcagtcggt atccgaaatg gagtaacgca tatgatttta acttttctga gaccgagaaa     2040

tataaggata tagcaggttt ttacagagag gttgaagaac aaggatataa agtatcattt     2100

gaaagtgcgt ctaaaaaaga agttgataaa ttggtagaag aaggaaaatt atacatgttc     2160

caaatttata ataaagactt ttcggataaa agtcatggaa cgccaaatct tcatacaatg     2220

tattttaagt tgctgtttga tgaaaataat catggtcaaa ttaggctttc tggtggtgct     2280

gagctattca tgcgacgtgc aagtttgaaa aaggaagaat tagttgtgca tcctgccaat     2340

agcccgatag cgaataaaaa cccggataat ccaaagaaaa cgactacgtt gtcatatgat     2400

gtatacaagg acaaaagatt ttcggaagat cagtatgagt tgcatatacc tattgcaata     2460

aataaatgcc ctaaaaatat atttaagata aatacagagg ttagagtgct gctgaagcat     2520

gatgataatc cttatgttat aggaattgat aggggggaga gaaatttact ttacattgtg     2580

gtggttgatg gtaagggtaa tattgtggag caatattcgc tgaatgaaat aattaataat     2640

tttaatggaa ttagaattaa gacggattac cattcacttt tggataaaaa ggagaaggaa     2700

agatttgaag ctcgtcaaaa ttggacgtct atagaaaaca ttaaagaact aaaagccgga     2760

tatattagtc aggttgttca taagatatgt gagttggtag aaaaatatga tgcggtaatt     2820

gcacttgaag atttgaattc tggttttaag aatagtcgag ttaaagttga aaagcaagta     2880

tatcagaaat ttgaaaaaat gctgattgat aaacttaact atatggtaga taagaaatct     2940

aatccttgcg ctacgggtgg tgctctgaaa ggctatcaaa ttactaacaa gtttgagagt     3000

tttaagtcga tgagtacaca aaatggtttt attttttata ttccggcgtg gttgactagc     3060

aaaattgatc cgtcaacagg atttgtaaat ttgttgaaaa caaagtatac gagcattgca     3120

gattcaaaga aatttataag ttcttttgac agaattatgt atgtacctga agaagattta     3180

ttcgagtttg cattagatta taagaatttt tctcggacag acgcggatta tataaaaaaa     3240

tggaaactct atagctatgg taacaggatt agaatattta gaaatcctaa aaaaaataat     3300

gtatttgatt gggaagaggt atgtcttaca tcagcctata aggaactttt taataaatat     3360

gggattaatt atcagcaagg agatatacga gctctcttat gtgaacagag tgataaggca     3420

ttctatagct cttttatggc attaatgtca ctcatgctgc aaatgagaaa tagtataaca     3480

ggtaggacgg atgtagattt tttgatttca ccagtaaaaa attctgacgg tattttttat     3540

gattccagaa attatgaagc tcaggaaaat gcaatattac cgaaaaatgc agatgctaat     3600

ggggcttata atatcgcaag aaaagttttg tgggctatag gtcagtttaa aaaggctgaa     3660

gatgaaaaac ttgataaggt taaaattgca atatcaaata aggaatggct cgaatatgcg     3720

caaacaagtg ttaagcattg a                                               3741


<210> 37
<211> 1228
<212> PRT
<213> Lachnospiraceae bacterium


<220>
<223> Lachnospiraceae bacterium (strain ND2006)

<400> 37
Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210> 38
<211> 1064
<212> PRT
<213> Bradyrhizobium sp.


<220>
<223> Bradyrhizobium sp. BTAi1

<400> 38
Met Lys Arg Thr Ser Leu Arg Ala Tyr Arg Leu Gly Val Asp Leu Gly 
1               5                   10                  15      


Ala Asn Ser Leu Gly Trp Phe Val Val Trp Leu Asp Asp His Gly Gln 
            20                  25                  30          


Pro Glu Gly Leu Gly Pro Gly Gly Val Arg Ile Phe Pro Asp Gly Arg 
        35                  40                  45              


Asn Pro Gln Ser Lys Gln Ser Asn Ala Ala Gly Arg Arg Leu Ala Arg 
    50                  55                  60                  


Ser Ala Arg Arg Arg Arg Asp Arg Tyr Leu Gln Arg Arg Gly Lys Leu 
65                  70                  75                  80  


Met Gly Leu Leu Val Lys His Gly Leu Met Pro Ala Asp Glu Pro Ala 
                85                  90                  95      


Arg Lys Arg Leu Glu Cys Leu Asp Pro Tyr Gly Leu Arg Ala Lys Ala 
            100                 105                 110         


Leu Asp Glu Val Leu Pro Leu His His Val Gly Arg Ala Leu Phe His 
        115                 120                 125             


Leu Asn Gln Arg Arg Gly Leu Phe Ala Asn Arg Ala Ile Glu Gln Gly 
    130                 135                 140                 


Asp Lys Asp Ala Ser Ala Ile Lys Ala Ala Ala Gly Arg Leu Gln Thr 
145                 150                 155                 160 


Ser Met Gln Ala Cys Gly Ala Arg Thr Leu Gly Glu Phe Leu Asn Arg 
                165                 170                 175     


Arg His Gln Leu Arg Ala Thr Val Arg Ala Arg Ser Pro Val Gly Gly 
            180                 185                 190         


Asp Val Gln Ala Arg Tyr Glu Phe Tyr Pro Thr Arg Ala Met Val Asp 
        195                 200                 205             


Ala Glu Phe Glu Ala Ile Trp Ala Ala Gln Ala Pro His His Pro Thr 
    210                 215                 220                 


Met Thr Ala Glu Ala His Asp Thr Ile Arg Glu Ala Ile Phe Ser Gln 
225                 230                 235                 240 


Arg Ala Met Lys Arg Pro Ser Ile Gly Lys Cys Ser Leu Asp Pro Ala 
                245                 250                 255     


Thr Ser Gln Asp Asp Val Asp Gly Phe Arg Cys Ala Trp Ser His Pro 
            260                 265                 270         


Leu Ala Gln Arg Phe Arg Ile Trp Gln Asp Val Arg Asn Leu Ala Val 
        275                 280                 285             


Val Glu Thr Gly Pro Thr Ser Ser Arg Leu Gly Lys Glu Asp Gln Asp 
    290                 295                 300                 


Lys Val Ala Arg Ala Leu Leu Gln Thr Asp Gln Leu Ser Phe Asp Glu 
305                 310                 315                 320 


Ile Arg Gly Leu Leu Gly Leu Pro Ser Asp Ala Arg Phe Asn Leu Glu 
                325                 330                 335     


Ser Asp Arg Arg Asp His Leu Lys Gly Asp Ala Thr Gly Ala Ile Leu 
            340                 345                 350         


Ser Ala Arg Arg His Phe Gly Pro Ala Trp His Asp Arg Ser Leu Asp 
        355                 360                 365             


Arg Gln Ile Asp Ile Val Ala Leu Leu Glu Ser Ala Leu Asp Glu Ala 
    370                 375                 380                 


Ala Ile Ile Ala Ser Leu Gly Thr Thr His Ser Leu Asp Glu Ala Ala 
385                 390                 395                 400 


Ala Gln Arg Ala Leu Ser Ala Leu Leu Pro Asp Gly Tyr Cys Arg Leu 
                405                 410                 415     


Gly Leu Arg Ala Ile Lys Arg Val Leu Pro Leu Met Glu Ala Gly Arg 
            420                 425                 430         


Thr Tyr Ala Glu Ala Ala Ser Ala Ala Gly Tyr Asp His Ala Leu Leu 
        435                 440                 445             


Pro Gly Gly Lys Leu Ser Pro Thr Gly Tyr Leu Pro Tyr Tyr Gly Gln 
    450                 455                 460                 


Trp Leu Gln Asn Asp Val Val Gly Ser Asp Asp Glu Arg Asp Thr Asn 
465                 470                 475                 480 


Glu Arg Arg Trp Gly Arg Leu Pro Asn Pro Thr Val His Ile Gly Ile 
                485                 490                 495     


Gly Gln Leu Arg Arg Val Val Asn Glu Leu Ile Arg Trp His Gly Pro 
            500                 505                 510         


Pro Ala Glu Ile Thr Val Glu Leu Thr Arg Asp Leu Lys Leu Ser Pro 
        515                 520                 525             


Arg Arg Leu Ala Glu Leu Glu Arg Glu Gln Ala Glu Asn Gln Arg Lys 
    530                 535                 540                 


Asn Asp Lys Arg Thr Ser Leu Leu Arg Lys Leu Gly Leu Pro Ala Ser 
545                 550                 555                 560 


Thr His Asn Leu Leu Lys Leu Arg Leu Trp Asp Glu Gln Gly Asp Val 
                565                 570                 575     


Ala Ser Glu Cys Pro Tyr Thr Gly Glu Ala Ile Gly Leu Glu Arg Leu 
            580                 585                 590         


Val Ser Asp Asp Val Asp Ile Asp His Leu Ile Pro Phe Ser Ile Ser 
        595                 600                 605             


Trp Asp Asp Ser Ala Ala Asn Lys Val Val Cys Met Arg Tyr Ala Asn 
    610                 615                 620                 


Arg Glu Lys Gly Asn Arg Thr Pro Phe Glu Ala Phe Gly His Arg Gln 
625                 630                 635                 640 


Gly Arg Pro Tyr Asp Trp Ala Asp Ile Ala Glu Arg Ala Ala Arg Leu 
                645                 650                 655     


Pro Arg Gly Lys Arg Trp Arg Phe Gly Pro Gly Ala Arg Ala Gln Phe 
            660                 665                 670         


Glu Glu Leu Gly Asp Phe Gln Ala Arg Leu Leu Asn Glu Thr Ser Trp 
        675                 680                 685             


Leu Ala Arg Val Ala Lys Gln Tyr Leu Ala Ala Val Thr His Pro His 
    690                 695                 700                 


Arg Ile His Val Leu Pro Gly Arg Leu Thr Ala Leu Leu Arg Ala Thr 
705                 710                 715                 720 


Trp Glu Leu Asn Asp Leu Leu Pro Gly Ser Asp Asp Arg Ala Ala Lys 
                725                 730                 735     


Ser Arg Lys Asp His Arg His His Ala Ile Asp Ala Leu Val Ala Ala 
            740                 745                 750         


Leu Thr Asp Gln Ala Leu Leu Arg Arg Met Ala Asn Ala His Asp Asp 
        755                 760                 765             


Thr Arg Arg Lys Ile Glu Val Leu Leu Pro Trp Pro Thr Phe Arg Ile 
    770                 775                 780                 


Asp Leu Glu Thr Arg Leu Lys Ala Met Leu Val Ser His Lys Pro Asp 
785                 790                 795                 800 


His Gly Leu Gln Ala Arg Leu His Glu Asp Thr Ala Tyr Gly Thr Val 
                805                 810                 815     


Glu His Pro Glu Thr Glu Asp Gly Ala Asn Leu Val Tyr Arg Lys Thr 
            820                 825                 830         


Phe Val Asp Ile Ser Glu Lys Glu Ile Asp Arg Ile Arg Asp Arg Arg 
        835                 840                 845             


Leu Arg Asp Leu Val Arg Ala His Val Ala Gly Glu Arg Gln Gln Gly 
    850                 855                 860                 


Lys Thr Leu Lys Ala Ala Val Leu Ser Phe Ala Gln Arg Arg Asp Ile 
865                 870                 875                 880 


Ala Gly His Pro Asn Gly Ile Arg His Val Arg Leu Thr Lys Ser Ile 
                885                 890                 895     


Lys Pro Asp Tyr Leu Val Pro Ile Arg Asp Lys Ala Gly Arg Ile Tyr 
            900                 905                 910         


Lys Ser Tyr Asn Ala Gly Glu Asn Ala Phe Val Asp Ile Leu Gln Ala 
        915                 920                 925             


Glu Ser Gly Arg Trp Ile Ala Arg Ala Thr Thr Val Phe Gln Ala Asn 
    930                 935                 940                 


Gln Ala Asn Glu Ser His Asp Ala Pro Ala Ala Gln Pro Ile Met Arg 
945                 950                 955                 960 


Val Phe Lys Gly Asp Met Leu Arg Ile Asp His Ala Gly Ala Glu Lys 
                965                 970                 975     


Phe Val Lys Ile Val Arg Leu Ser Pro Ser Asn Asn Leu Leu Tyr Leu 
            980                 985                 990         


Val Glu His His Gln Ala Gly Val  Phe Gln Thr Arg His  Asp Asp Pro 
        995                 1000                 1005             


Glu Asp  Ser Phe Arg Trp Leu  Phe Ala Ser Phe Asp  Lys Leu Arg 
    1010                 1015                 1020             


Glu Trp  Asn Ala Glu Leu Val  Arg Ile Asp Thr Leu  Gly Gln Pro 
    1025                 1030                 1035             


Trp Arg  Arg Lys Arg Gly Leu  Glu Thr Gly Ser Glu  Asp Ala Thr 
    1040                 1045                 1050             


Arg Ile  Gly Trp Thr Arg Pro  Lys Lys Trp Pro 
    1055                 1060                 


<210> 39
<211> 1035
<212> PRT
<213> Candidatus Puniceispirillum marinum

<400> 39
Met Arg Arg Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp Cys 
1               5                   10                  15      


Leu Leu Asp Leu Gly Asp Asp Gly Glu Pro Val Ser Ile Phe Arg Thr 
            20                  25                  30          


Gly Ala Arg Ile Phe Ser Asp Gly Arg Asp Pro Lys Ser Leu Gly Ser 
        35                  40                  45              


Leu Lys Ala Thr Arg Arg Glu Ala Arg Leu Thr Arg Arg Arg Arg Asp 
    50                  55                  60                  


Arg Phe Ile Gln Arg Gln Lys Asn Leu Ile Asn Ala Leu Val Lys Tyr 
65                  70                  75                  80  


Gly Leu Met Pro Ala Asp Glu Ile Gln Arg Gln Ala Leu Ala Tyr Lys 
                85                  90                  95      


Asp Pro Tyr Pro Ile Arg Lys Lys Ala Leu Asp Glu Ala Ile Asp Pro 
            100                 105                 110         


Tyr Glu Met Gly Arg Ala Ile Phe His Ile Asn Gln Arg Arg Gly Phe 
        115                 120                 125             


Lys Ser Asn Arg Lys Ser Ala Asp Asn Glu Ala Gly Val Val Lys Gln 
    130                 135                 140                 


Ser Ile Ala Asp Leu Glu Met Lys Leu Gly Glu Ala Gly Ala Arg Thr 
145                 150                 155                 160 


Ile Gly Glu Phe Leu Ala Asp Arg Gln Ala Thr Asn Asp Thr Val Arg 
                165                 170                 175     


Ala Arg Arg Leu Ser Gly Thr Asn Ala Leu Tyr Glu Phe Tyr Pro Asp 
            180                 185                 190         


Arg Tyr Met Leu Glu Gln Glu Phe Asp Thr Leu Trp Ala Lys Gln Ala 
        195                 200                 205             


Ala Phe Asn Pro Ser Leu Tyr Ile Glu Ala Ala Arg Glu Arg Leu Lys 
    210                 215                 220                 


Glu Ile Val Phe Phe Gln Arg Lys Leu Lys Pro Gln Glu Val Gly Arg 
225                 230                 235                 240 


Cys Ile Phe Leu Ser Asp Glu Asp Arg Ile Ser Lys Ala Leu Pro Ser 
                245                 250                 255     


Phe Gln Arg Phe Arg Ile Tyr Gln Glu Leu Ser Asn Leu Ala Trp Ile 
            260                 265                 270         


Asp His Asp Gly Val Ala His Arg Ile Thr Ala Ser Leu Ala Leu Arg 
        275                 280                 285             


Asp His Leu Phe Asp Glu Leu Glu His Lys Lys Lys Leu Thr Phe Lys 
    290                 295                 300                 


Ala Met Arg Ala Ile Leu Arg Lys Gln Gly Val Val Asp Tyr Pro Val 
305                 310                 315                 320 


Gly Phe Asn Leu Glu Ser Asp Asn Arg Asp His Leu Ile Gly Asn Leu 
                325                 330                 335     


Thr Ser Cys Ile Met Arg Asp Ala Lys Lys Met Ile Gly Ser Ala Trp 
            340                 345                 350         


Asp Arg Leu Asp Glu Glu Glu Gln Asp Ser Phe Ile Leu Met Leu Gln 
        355                 360                 365             


Asp Asp Gln Lys Gly Asp Asp Glu Val Arg Ser Ile Leu Thr Gln Gln 
    370                 375                 380                 


Tyr Gly Leu Ser Asp Asp Val Ala Glu Asp Cys Leu Asp Val Arg Leu 
385                 390                 395                 400 


Pro Asp Gly His Gly Ser Leu Ser Lys Lys Ala Ile Asp Arg Ile Leu 
                405                 410                 415     


Pro Val Leu Arg Asp Gln Gly Leu Ile Tyr Tyr Asp Ala Val Lys Glu 
            420                 425                 430         


Ala Gly Leu Gly Glu Ala Asn Leu Tyr Asp Pro Tyr Ala Ala Leu Ser 
        435                 440                 445             


Asp Lys Leu Asp Tyr Tyr Gly Lys Ala Leu Ala Gly His Val Met Gly 
    450                 455                 460                 


Ala Ser Gly Lys Phe Glu Asp Ser Asp Glu Lys Arg Tyr Gly Thr Ile 
465                 470                 475                 480 


Ser Asn Pro Thr Val His Ile Ala Leu Asn Gln Val Arg Ala Val Val 
                485                 490                 495     


Asn Glu Leu Ile Arg Leu His Gly Lys Pro Asp Glu Val Val Ile Glu 
            500                 505                 510         


Ile Gly Arg Asp Leu Pro Met Gly Ala Asp Gly Lys Arg Glu Leu Glu 
        515                 520                 525             


Arg Phe Gln Lys Glu Gly Arg Ala Lys Asn Glu Arg Ala Arg Asp Glu 
    530                 535                 540                 


Leu Lys Lys Leu Gly His Ile Asp Ser Arg Glu Ser Arg Gln Lys Phe 
545                 550                 555                 560 


Gln Leu Trp Glu Gln Leu Ala Lys Glu Pro Val Asp Arg Cys Cys Pro 
                565                 570                 575     


Phe Thr Gly Lys Met Met Ser Ile Ser Asp Leu Phe Ser Asp Lys Val 
            580                 585                 590         


Glu Ile Glu His Leu Leu Pro Phe Ser Leu Thr Leu Asp Asp Ser Met 
        595                 600                 605             


Ala Asn Lys Thr Val Cys Phe Arg Gln Ala Asn Arg Asp Lys Gly Asn 
    610                 615                 620                 


Arg Ala Pro Phe Asp Ala Phe Gly Asn Ser Pro Ala Gly Tyr Asp Trp 
625                 630                 635                 640 


Gln Glu Ile Leu Gly Arg Ser Gln Asn Leu Pro Tyr Ala Lys Arg Trp 
                645                 650                 655     


Arg Phe Leu Pro Asp Ala Met Lys Arg Phe Glu Ala Asp Gly Gly Phe 
            660                 665                 670         


Leu Glu Arg Gln Leu Asn Asp Thr Arg Tyr Ile Ser Arg Tyr Thr Thr 
        675                 680                 685             


Glu Tyr Ile Ser Thr Ile Ile Pro Lys Asn Lys Ile Trp Val Val Thr 
    690                 695                 700                 


Gly Arg Leu Thr Ser Leu Leu Arg Gly Phe Trp Gly Leu Asn Ser Ile 
705                 710                 715                 720 


Leu Arg Gly His Asn Thr Asp Asp Gly Thr Pro Ala Lys Lys Ser Arg 
                725                 730                 735     


Asp Asp His Arg His His Ala Ile Asp Ala Ile Val Val Gly Met Thr 
            740                 745                 750         


Ser Arg Gly Leu Leu Gln Lys Val Ser Lys Ala Ala Arg Arg Ser Glu 
        755                 760                 765             


Asp Leu Asp Leu Thr Arg Leu Phe Glu Gly Arg Ile Asp Pro Trp Asp 
    770                 775                 780                 


Gly Phe Arg Asp Glu Val Lys Lys His Ile Asp Ala Ile Ile Val Ser 
785                 790                 795                 800 


His Arg Pro Arg Lys Lys Ser Gln Gly Ala Leu His Asn Asp Thr Ala 
                805                 810                 815     


Tyr Gly Ile Val Glu His Ala Glu Asn Gly Ala Ser Thr Val Val His 
            820                 825                 830         


Arg Val Pro Ile Thr Ser Leu Gly Lys Gln Ser Asp Ile Glu Lys Val 
        835                 840                 845             


Arg Asp Pro Leu Ile Lys Ser Ala Leu Leu Asn Glu Thr Ala Gly Leu 
    850                 855                 860                 


Ser Gly Lys Ser Phe Glu Asn Ala Val Gln Lys Trp Cys Ala Asp Asn 
865                 870                 875                 880 


Ser Ile Lys Ser Leu Arg Ile Val Glu Thr Val Ser Ile Ile Pro Ile 
                885                 890                 895     


Thr Asp Lys Glu Gly Val Ala Tyr Lys Gly Tyr Lys Gly Asp Gly Asn 
            900                 905                 910         


Ala Tyr Met Asp Ile Tyr Gln Asp Pro Thr Ser Ser Lys Trp Lys Gly 
        915                 920                 925             


Glu Ile Val Ser Arg Phe Asp Ala Asn Gln Lys Gly Phe Ile Pro Ser 
    930                 935                 940                 


Trp Gln Ser Gln Phe Pro Thr Ala Arg Leu Ile Met Arg Leu Arg Ile 
945                 950                 955                 960 


Asn Asp Leu Leu Lys Leu Gln Asp Gly Glu Ile Glu Glu Ile Tyr Arg 
                965                 970                 975     


Val Gln Arg Leu Ser Gly Ser Lys Ile Leu Met Ala Pro His Thr Glu 
            980                 985                 990         


Ala Asn Val Asp Ala Arg Asp Arg  Asp Lys Asn Asp Thr  Phe Lys Leu 
        995                 1000                 1005             


Thr Ser  Lys Ser Pro Gly Lys  Leu Gln Ser Ala Ser  Ala Arg Lys 
    1010                 1015                 1020             


Val His  Ile Ser Pro Thr Gly  Leu Ile Arg Glu Gly  
    1025                 1030                 1035 


<210> 40
<211> 1358
<212> PRT
<213> Acidaminococcus sp.

<400> 40
Met Gly Lys Met Tyr Tyr Leu Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ala Val Thr Asp Pro Ser Tyr His Leu Leu Lys Phe Lys Gly 
            20                  25                  30          


Glu Pro Met Trp Gly Ala His Val Phe Ala Ala Gly Asn Gln Ser Ala 
        35                  40                  45              


Glu Arg Arg Ser Phe Arg Thr Ser Arg Arg Arg Leu Asp Arg Arg Gln 
    50                  55                  60                  


Gln Arg Val Lys Leu Val Gln Glu Ile Phe Ala Pro Val Ile Ser Pro 
65                  70                  75                  80  


Ile Asp Pro Arg Phe Phe Ile Arg Leu His Glu Ser Ala Leu Trp Arg 
                85                  90                  95      


Asp Asp Val Ala Glu Thr Asp Lys His Ile Phe Phe Asn Asp Pro Thr 
            100                 105                 110         


Tyr Thr Asp Lys Glu Tyr Tyr Ser Asp Tyr Pro Thr Ile His His Leu 
        115                 120                 125             


Ile Val Asp Leu Met Glu Ser Ser Glu Lys His Asp Pro Arg Leu Val 
    130                 135                 140                 


Tyr Leu Ala Val Ala Trp Leu Val Ala His Arg Gly His Phe Leu Asn 
145                 150                 155                 160 


Glu Val Asp Lys Asp Asn Ile Gly Asp Val Leu Ser Phe Asp Ala Phe 
                165                 170                 175     


Tyr Pro Glu Phe Leu Ala Phe Leu Ser Asp Asn Gly Val Ser Pro Trp 
            180                 185                 190         


Val Cys Glu Ser Lys Ala Leu Gln Ala Thr Leu Leu Ser Arg Asn Ser 
        195                 200                 205             


Val Asn Asp Lys Tyr Lys Ala Leu Lys Ser Leu Ile Phe Gly Ser Gln 
    210                 215                 220                 


Lys Pro Glu Asp Asn Phe Asp Ala Asn Ile Ser Glu Asp Gly Leu Ile 
225                 230                 235                 240 


Gln Leu Leu Ala Gly Lys Lys Val Lys Val Asn Lys Leu Phe Pro Gln 
                245                 250                 255     


Glu Ser Asn Asp Ala Ser Phe Thr Leu Asn Asp Lys Glu Asp Ala Ile 
            260                 265                 270         


Glu Glu Ile Leu Gly Thr Leu Thr Pro Asp Glu Cys Glu Trp Ile Ala 
        275                 280                 285             


His Ile Arg Arg Leu Phe Asp Trp Ala Ile Met Lys His Ala Leu Lys 
    290                 295                 300                 


Asp Gly Arg Thr Ile Ser Glu Ser Lys Val Lys Leu Tyr Glu Gln His 
305                 310                 315                 320 


His His Asp Leu Thr Gln Leu Lys Tyr Phe Val Lys Thr Tyr Leu Ala 
                325                 330                 335     


Lys Glu Tyr Asp Asp Ile Phe Arg Asn Val Asp Ser Glu Thr Thr Lys 
            340                 345                 350         


Asn Tyr Val Ala Tyr Ser Tyr His Val Lys Glu Val Lys Gly Thr Leu 
        355                 360                 365             


Pro Lys Asn Lys Ala Thr Gln Glu Glu Phe Cys Lys Tyr Val Leu Gly 
    370                 375                 380                 


Lys Val Lys Asn Ile Glu Cys Ser Glu Ala Asp Lys Val Asp Phe Asp 
385                 390                 395                 400 


Glu Met Ile Gln Arg Leu Thr Asp Asn Ser Phe Met Pro Lys Gln Val 
                405                 410                 415     


Ser Gly Glu Asn Arg Val Ile Pro Tyr Gln Leu Tyr Tyr Tyr Glu Leu 
            420                 425                 430         


Lys Thr Ile Leu Asn Lys Ala Ala Ser Tyr Leu Pro Phe Leu Thr Gln 
        435                 440                 445             


Cys Gly Lys Asp Ala Ile Ser Asn Gln Asp Lys Leu Leu Ser Ile Met 
    450                 455                 460                 


Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Arg Lys Asp Asn Ser 
465                 470                 475                 480 


Glu His Ala Trp Leu Glu Arg Lys Ala Gly Lys Ile Tyr Pro Trp Asn 
                485                 490                 495     


Phe Asn Asp Lys Val Asp Leu Asp Lys Ser Glu Glu Ala Phe Ile Arg 
            500                 505                 510         


Arg Met Thr Asn Thr Cys Thr Tyr Tyr Pro Gly Glu Asp Val Leu Pro 
        515                 520                 525             


Leu Asp Ser Leu Ile Tyr Glu Lys Phe Met Ile Leu Asn Glu Ile Asn 
    530                 535                 540                 


Asn Ile Arg Ile Asp Gly Tyr Pro Ile Ser Val Asp Val Lys Gln Gln 
545                 550                 555                 560 


Val Phe Gly Leu Phe Glu Lys Lys Arg Arg Val Thr Val Lys Asp Ile 
                565                 570                 575     


Gln Asn Leu Leu Leu Ser Leu Gly Ala Leu Asp Lys His Gly Lys Leu 
            580                 585                 590         


Thr Gly Ile Asp Thr Thr Ile His Ser Asn Tyr Asn Thr Tyr His His 
        595                 600                 605             


Phe Lys Ser Leu Met Glu Arg Gly Val Leu Thr Arg Asp Asp Val Glu 
    610                 615                 620                 


Arg Ile Val Glu Arg Met Thr Tyr Ser Asp Asp Thr Lys Arg Val Arg 
625                 630                 635                 640 


Leu Trp Leu Asn Asn Asn Tyr Gly Thr Leu Thr Ala Asp Asp Val Lys 
                645                 650                 655     


His Ile Ser Arg Leu Arg Lys His Asp Phe Gly Arg Leu Ser Lys Met 
            660                 665                 670         


Phe Leu Thr Gly Leu Lys Gly Val His Lys Glu Thr Gly Glu Arg Ala 
        675                 680                 685             


Ser Ile Leu Asp Phe Met Trp Asn Thr Asn Asp Asn Leu Met Gln Leu 
    690                 695                 700                 


Leu Ser Glu Cys Tyr Thr Phe Ser Asp Glu Ile Thr Lys Leu Gln Glu 
705                 710                 715                 720 


Ala Tyr Tyr Ala Lys Ala Gln Leu Ser Leu Asn Asp Phe Leu Asp Ser 
                725                 730                 735     


Met Tyr Ile Ser Asn Ala Val Lys Arg Pro Ile Tyr Arg Thr Leu Ala 
            740                 745                 750         


Val Val Asn Asp Ile Arg Lys Ala Cys Gly Thr Ala Pro Lys Arg Ile 
        755                 760                 765             


Phe Ile Glu Met Ala Arg Asp Gly Glu Ser Lys Lys Lys Arg Ser Val 
    770                 775                 780                 


Thr Arg Arg Glu Gln Ile Lys Asn Leu Tyr Arg Ser Ile Arg Lys Asp 
785                 790                 795                 800 


Phe Gln Gln Glu Val Asp Phe Leu Glu Lys Ile Leu Glu Asn Lys Ser 
                805                 810                 815     


Asp Gly Gln Leu Gln Ser Asp Ala Leu Tyr Leu Tyr Phe Ala Gln Leu 
            820                 825                 830         


Gly Arg Asp Met Tyr Thr Gly Asp Pro Ile Lys Leu Glu His Ile Lys 
        835                 840                 845             


Asp Gln Ser Phe Tyr Asn Ile Asp His Ile Tyr Pro Gln Ser Met Val 
    850                 855                 860                 


Lys Asp Asp Ser Leu Asp Asn Lys Val Leu Val Gln Ser Glu Ile Asn 
865                 870                 875                 880 


Gly Glu Lys Ser Ser Arg Tyr Pro Leu Asp Ala Ala Ile Arg Asn Lys 
                885                 890                 895     


Met Lys Pro Leu Trp Asp Ala Tyr Tyr Asn His Gly Leu Ile Ser Leu 
            900                 905                 910         


Lys Lys Tyr Gln Arg Leu Thr Arg Ser Thr Pro Phe Thr Asp Asp Glu 
        915                 920                 925             


Lys Trp Asp Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Ser Thr 
    930                 935                 940                 


Lys Ala Leu Ala Ile Leu Leu Lys Arg Lys Phe Pro Asp Thr Glu Ile 
945                 950                 955                 960 


Val Tyr Ser Lys Ala Gly Leu Ser Ser Asp Phe Arg His Glu Phe Gly 
                965                 970                 975     


Leu Val Lys Ser Arg Asn Ile Asn Asp Leu His His Ala Lys Asp Ala 
            980                 985                 990         


Phe Leu Ala Ile Val Thr Gly Asn  Val Tyr His Glu Arg  Phe Asn Arg 
        995                 1000                 1005             


Arg Trp  Phe Met Val Asn Gln  Pro Tyr Ser Val Lys  Thr Lys Thr 
    1010                 1015                 1020             


Leu Phe  Thr His Ser Ile Lys  Asn Gly Asn Phe Val  Ala Trp Asn 
    1025                 1030                 1035             


Gly Glu  Glu Asp Leu Gly Arg  Ile Val Lys Met Leu  Lys Gln Asn 
    1040                 1045                 1050             


Lys Asn  Thr Ile His Phe Thr  Arg Phe Ser Phe Asp  Arg Lys Glu 
    1055                 1060                 1065             


Gly Leu  Phe Asp Ile Gln Pro  Leu Lys Ala Ser Thr  Gly Leu Val 
    1070                 1075                 1080             


Pro Arg  Lys Ala Gly Leu Asp  Val Val Lys Tyr Gly  Gly Tyr Asp 
    1085                 1090                 1095             


Lys Ser  Thr Ala Ala Tyr Tyr  Leu Leu Val Arg Phe  Thr Leu Glu 
    1100                 1105                 1110             


Asp Lys  Lys Thr Gln His Lys  Leu Met Met Ile Pro  Val Glu Gly 
    1115                 1120                 1125             


Leu Tyr  Lys Ala Arg Ile Asp  His Asp Lys Glu Phe  Leu Thr Asp 
    1130                 1135                 1140             


Tyr Ala  Gln Thr Thr Ile Ser  Glu Ile Leu Gln Lys  Asp Lys Gln 
    1145                 1150                 1155             


Lys Val  Ile Asn Ile Met Phe  Pro Met Gly Thr Arg  His Ile Lys 
    1160                 1165                 1170             


Leu Asn  Ser Met Ile Ser Ile  Asp Gly Phe Tyr Leu  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ser Ser Lys Gly Lys  Ser Val Leu Cys His  Ala Met Val 
    1190                 1195                 1200             


Pro Leu  Ile Val Pro His Lys  Ile Glu Cys Tyr Ile  Lys Ala Met 
    1205                 1210                 1215             


Glu Ser  Phe Ala Arg Lys Phe  Lys Glu Asn Asn Lys  Leu Arg Ile 
    1220                 1225                 1230             


Val Glu  Lys Phe Asp Lys Ile  Thr Val Glu Asp Asn  Leu Asn Leu 
    1235                 1240                 1245             


Tyr Glu  Leu Phe Leu Gln Lys  Leu Gln His Asn Pro  Tyr Asn Lys 
    1250                 1255                 1260             


Phe Phe  Ser Thr Gln Phe Asp  Val Leu Thr Asn Gly  Arg Ser Thr 
    1265                 1270                 1275             


Phe Thr  Lys Leu Ser Pro Glu  Glu Gln Val Gln Thr  Leu Leu Asn 
    1280                 1285                 1290             


Ile Leu  Ser Ile Phe Lys Thr  Cys Arg Ser Ser Gly  Cys Asp Leu 
    1295                 1300                 1305             


Lys Ser  Ile Asn Gly Ser Ala  Gln Ala Ala Arg Ile  Met Ile Ser 
    1310                 1315                 1320             


Ala Asp  Leu Thr Gly Leu Ser  Lys Lys Tyr Ser Asp  Ile Arg Leu 
    1325                 1330                 1335             


Val Glu  Gln Ser Ala Ser Gly  Leu Phe Val Ser Lys  Ser Gln Asn 
    1340                 1345                 1350             


Leu Leu  Glu Tyr Leu 
    1355             


<210> 41
<211> 1358
<212> PRT
<213> Acidaminococcus sp.


<220>
<223> Acidaminococcus sp. D21

<400> 41
Met Gly Lys Met Tyr Tyr Leu Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ala Val Thr Asp Pro Ser Tyr His Leu Leu Lys Phe Lys Gly 
            20                  25                  30          


Glu Pro Met Trp Gly Ala His Val Phe Ala Ala Gly Asn Gln Ser Ala 
        35                  40                  45              


Glu Arg Arg Ser Phe Arg Thr Ser Arg Arg Arg Leu Asp Arg Arg Gln 
    50                  55                  60                  


Gln Arg Val Lys Leu Val Gln Glu Ile Phe Ala Pro Val Ile Ser Pro 
65                  70                  75                  80  


Ile Asp Pro Arg Phe Phe Ile Arg Leu His Glu Ser Ala Leu Trp Arg 
                85                  90                  95      


Asp Asp Val Ala Glu Thr Asp Lys His Ile Phe Phe Asn Asp Pro Thr 
            100                 105                 110         


Tyr Thr Asp Lys Glu Tyr Tyr Ser Asp Tyr Pro Thr Ile His His Leu 
        115                 120                 125             


Ile Val Asp Leu Met Glu Ser Ser Glu Lys His Asp Pro Arg Leu Val 
    130                 135                 140                 


Tyr Leu Ala Val Ala Trp Leu Val Ala His Arg Gly His Phe Leu Asn 
145                 150                 155                 160 


Glu Val Asp Lys Asp Asn Ile Gly Asp Val Leu Ser Phe Asp Ala Phe 
                165                 170                 175     


Tyr Pro Glu Phe Leu Ala Phe Leu Ser Asp Asn Gly Val Ser Pro Trp 
            180                 185                 190         


Val Cys Glu Ser Lys Ala Leu Gln Ala Thr Leu Leu Ser Arg Asn Ser 
        195                 200                 205             


Val Asn Asp Lys Tyr Lys Ala Leu Lys Ser Leu Ile Phe Gly Ser Gln 
    210                 215                 220                 


Lys Pro Glu Asp Asn Phe Asp Ala Asn Ile Ser Glu Asp Gly Leu Ile 
225                 230                 235                 240 


Gln Leu Leu Ala Gly Lys Lys Val Lys Val Asn Lys Leu Phe Pro Gln 
                245                 250                 255     


Glu Ser Asn Asp Ala Ser Phe Thr Leu Asn Asp Lys Glu Asp Ala Ile 
            260                 265                 270         


Glu Glu Ile Leu Gly Thr Leu Thr Pro Asp Glu Cys Glu Trp Ile Ala 
        275                 280                 285             


His Ile Arg Arg Leu Phe Asp Trp Ala Ile Met Lys His Ala Leu Lys 
    290                 295                 300                 


Asp Gly Arg Thr Ile Ser Glu Ser Lys Val Lys Leu Tyr Glu Gln His 
305                 310                 315                 320 


His His Asp Leu Thr Gln Leu Lys Tyr Phe Val Lys Thr Tyr Leu Ala 
                325                 330                 335     


Lys Glu Tyr Asp Asp Ile Phe Arg Asn Val Asp Ser Glu Thr Thr Lys 
            340                 345                 350         


Asn Tyr Val Ala Tyr Ser Tyr His Val Lys Glu Val Lys Gly Thr Leu 
        355                 360                 365             


Pro Lys Asn Lys Ala Thr Gln Glu Glu Phe Cys Lys Tyr Val Leu Gly 
    370                 375                 380                 


Lys Val Lys Asn Ile Glu Cys Ser Glu Ala Asp Lys Val Asp Phe Asp 
385                 390                 395                 400 


Glu Met Ile Gln Arg Leu Thr Asp Asn Ser Phe Met Pro Lys Gln Val 
                405                 410                 415     


Ser Gly Glu Asn Arg Val Ile Pro Tyr Gln Leu Tyr Tyr Tyr Glu Leu 
            420                 425                 430         


Lys Thr Ile Leu Asn Lys Ala Ala Ser Tyr Leu Pro Phe Leu Thr Gln 
        435                 440                 445             


Cys Gly Lys Asp Ala Ile Ser Asn Gln Asp Lys Leu Leu Ser Ile Met 
    450                 455                 460                 


Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Arg Lys Asp Asn Ser 
465                 470                 475                 480 


Glu His Ala Trp Leu Glu Arg Lys Ala Gly Lys Ile Tyr Pro Trp Asn 
                485                 490                 495     


Phe Asn Asp Lys Val Asp Leu Asp Lys Ser Glu Glu Ala Phe Ile Arg 
            500                 505                 510         


Arg Met Thr Asn Thr Cys Thr Tyr Tyr Pro Gly Glu Asp Val Leu Pro 
        515                 520                 525             


Leu Asp Ser Leu Ile Tyr Glu Lys Phe Met Ile Leu Asn Glu Ile Asn 
    530                 535                 540                 


Asn Ile Arg Ile Asp Gly Tyr Pro Ile Ser Val Asp Val Lys Gln Gln 
545                 550                 555                 560 


Val Phe Gly Leu Phe Glu Lys Lys Arg Arg Val Thr Val Lys Asp Ile 
                565                 570                 575     


Gln Asn Leu Leu Leu Ser Leu Gly Ala Leu Asp Lys His Gly Lys Leu 
            580                 585                 590         


Thr Gly Ile Asp Thr Thr Ile His Ser Asn Tyr Asn Thr Tyr His His 
        595                 600                 605             


Phe Lys Ser Leu Met Glu Arg Gly Val Leu Thr Arg Asp Asp Val Glu 
    610                 615                 620                 


Arg Ile Val Glu Arg Met Thr Tyr Ser Asp Asp Thr Lys Arg Val Arg 
625                 630                 635                 640 


Leu Trp Leu Asn Asn Asn Tyr Gly Thr Leu Thr Ala Asp Asp Val Lys 
                645                 650                 655     


His Ile Ser Arg Leu Arg Lys His Asp Phe Gly Arg Leu Ser Lys Met 
            660                 665                 670         


Phe Leu Thr Gly Leu Lys Gly Val His Lys Glu Thr Gly Glu Arg Ala 
        675                 680                 685             


Ser Ile Leu Asp Phe Met Trp Asn Thr Asn Asp Asn Leu Met Gln Leu 
    690                 695                 700                 


Leu Ser Glu Cys Tyr Thr Phe Ser Asp Glu Ile Thr Lys Leu Gln Glu 
705                 710                 715                 720 


Ala Tyr Tyr Ala Lys Ala Gln Leu Ser Leu Asn Asp Phe Leu Asp Ser 
                725                 730                 735     


Met Tyr Ile Ser Asn Ala Val Lys Arg Pro Ile Tyr Arg Thr Leu Ala 
            740                 745                 750         


Val Val Asn Asp Ile Arg Lys Ala Cys Gly Thr Ala Pro Lys Arg Ile 
        755                 760                 765             


Phe Ile Glu Met Ala Arg Asp Gly Glu Ser Lys Lys Lys Arg Ser Val 
    770                 775                 780                 


Thr Arg Arg Glu Gln Ile Lys Asn Leu Tyr Arg Ser Ile Arg Lys Asp 
785                 790                 795                 800 


Phe Gln Gln Glu Val Asp Phe Leu Glu Lys Ile Leu Glu Asn Lys Ser 
                805                 810                 815     


Asp Gly Gln Leu Gln Ser Asp Ala Leu Tyr Leu Tyr Phe Ala Gln Leu 
            820                 825                 830         


Gly Arg Asp Met Tyr Thr Gly Asp Pro Ile Lys Leu Glu His Ile Lys 
        835                 840                 845             


Asp Gln Ser Phe Tyr Asn Ile Asp His Ile Tyr Pro Gln Ser Met Val 
    850                 855                 860                 


Lys Asp Asp Ser Leu Asp Asn Lys Val Leu Val Gln Ser Glu Ile Asn 
865                 870                 875                 880 


Gly Glu Lys Ser Ser Arg Tyr Pro Leu Asp Ala Ala Ile Arg Asn Lys 
                885                 890                 895     


Met Lys Pro Leu Trp Asp Ala Tyr Tyr Asn His Gly Leu Ile Ser Leu 
            900                 905                 910         


Lys Lys Tyr Gln Arg Leu Thr Arg Ser Thr Pro Phe Thr Asp Asp Glu 
        915                 920                 925             


Lys Trp Asp Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Ser Thr 
    930                 935                 940                 


Lys Ala Leu Ala Ile Leu Leu Lys Arg Lys Phe Pro Asp Thr Glu Ile 
945                 950                 955                 960 


Val Tyr Ser Lys Ala Gly Leu Ser Ser Asp Phe Arg His Glu Phe Gly 
                965                 970                 975     


Leu Val Lys Ser Arg Asn Ile Asn Asp Leu His His Ala Lys Asp Ala 
            980                 985                 990         


Phe Leu Ala Ile Val Thr Gly Asn  Val Tyr His Glu Arg  Phe Asn Arg 
        995                 1000                 1005             


Arg Trp  Phe Met Val Asn Gln  Pro Tyr Ser Val Lys  Thr Lys Thr 
    1010                 1015                 1020             


Leu Phe  Thr His Ser Ile Lys  Asn Gly Asn Phe Val  Ala Trp Asn 
    1025                 1030                 1035             


Gly Glu  Glu Asp Leu Gly Arg  Ile Val Lys Met Leu  Lys Gln Asn 
    1040                 1045                 1050             


Lys Asn  Thr Ile His Phe Thr  Arg Phe Ser Phe Asp  Arg Lys Glu 
    1055                 1060                 1065             


Gly Leu  Phe Asp Ile Gln Pro  Leu Lys Ala Ser Thr  Gly Leu Val 
    1070                 1075                 1080             


Pro Arg  Lys Ala Gly Leu Asp  Val Val Lys Tyr Gly  Gly Tyr Asp 
    1085                 1090                 1095             


Lys Ser  Thr Ala Ala Tyr Tyr  Leu Leu Val Arg Phe  Thr Leu Glu 
    1100                 1105                 1110             


Asp Lys  Lys Thr Gln His Lys  Leu Met Met Ile Pro  Val Glu Gly 
    1115                 1120                 1125             


Leu Tyr  Lys Ala Arg Ile Asp  His Asp Lys Glu Phe  Leu Thr Asp 
    1130                 1135                 1140             


Tyr Ala  Gln Thr Thr Ile Ser  Glu Ile Leu Gln Lys  Asp Lys Gln 
    1145                 1150                 1155             


Lys Val  Ile Asn Ile Met Phe  Pro Met Gly Thr Arg  His Ile Lys 
    1160                 1165                 1170             


Leu Asn  Ser Met Ile Ser Ile  Asp Gly Phe Tyr Leu  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ser Ser Lys Gly Lys  Ser Val Leu Cys His  Ala Met Val 
    1190                 1195                 1200             


Pro Leu  Ile Val Pro His Lys  Ile Glu Cys Tyr Ile  Lys Ala Met 
    1205                 1210                 1215             


Glu Ser  Phe Ala Arg Lys Phe  Lys Glu Asn Asn Lys  Leu Arg Ile 
    1220                 1225                 1230             


Val Glu  Lys Phe Asp Lys Ile  Thr Val Glu Asp Asn  Leu Asn Leu 
    1235                 1240                 1245             


Tyr Glu  Leu Phe Leu Gln Lys  Leu Gln His Asn Pro  Tyr Asn Lys 
    1250                 1255                 1260             


Phe Phe  Ser Thr Gln Phe Asp  Val Leu Thr Asn Gly  Arg Ser Thr 
    1265                 1270                 1275             


Phe Thr  Lys Leu Ser Pro Glu  Glu Gln Val Gln Thr  Leu Leu Asn 
    1280                 1285                 1290             


Ile Leu  Ser Ile Phe Lys Thr  Cys Arg Ser Ser Gly  Cys Asp Leu 
    1295                 1300                 1305             


Lys Ser  Ile Asn Gly Ser Ala  Gln Ala Ala Arg Ile  Met Ile Ser 
    1310                 1315                 1320             


Ala Asp  Leu Thr Gly Leu Ser  Lys Lys Tyr Ser Asp  Ile Arg Leu 
    1325                 1330                 1335             


Val Glu  Gln Ser Ala Ser Gly  Leu Phe Val Ser Lys  Ser Gln Asn 
    1340                 1345                 1350             


Leu Leu  Glu Tyr Leu 
    1355             


<210> 42
<211> 1138
<212> PRT
<213> Acidothermus cellulolyticus

<400> 42
Met Gly Gly Ser Glu Val Gly Thr Val Pro Val Thr Trp Arg Leu Gly 
1               5                   10                  15      


Val Asp Val Gly Glu Arg Ser Ile Gly Leu Ala Ala Val Ser Tyr Glu 
            20                  25                  30          


Glu Asp Lys Pro Lys Glu Ile Leu Ala Ala Val Ser Trp Ile His Asp 
        35                  40                  45              


Gly Gly Val Gly Asp Glu Arg Ser Gly Ala Ser Arg Leu Ala Leu Arg 
    50                  55                  60                  


Gly Met Ala Arg Arg Ala Arg Arg Leu Arg Arg Phe Arg Arg Ala Arg 
65                  70                  75                  80  


Leu Arg Asp Leu Asp Met Leu Leu Ser Glu Leu Gly Trp Thr Pro Leu 
                85                  90                  95      


Pro Asp Lys Asn Val Ser Pro Val Asp Ala Trp Leu Ala Arg Lys Arg 
            100                 105                 110         


Leu Ala Glu Glu Tyr Val Val Asp Glu Thr Glu Arg Arg Arg Leu Leu 
        115                 120                 125             


Gly Tyr Ala Val Ser His Met Ala Arg His Arg Gly Trp Arg Asn Pro 
    130                 135                 140                 


Trp Thr Thr Ile Lys Asp Leu Lys Asn Leu Pro Gln Pro Ser Asp Ser 
145                 150                 155                 160 


Trp Glu Arg Thr Arg Glu Ser Leu Glu Ala Arg Tyr Ser Val Ser Leu 
                165                 170                 175     


Glu Pro Gly Thr Val Gly Gln Trp Ala Gly Tyr Leu Leu Gln Arg Ala 
            180                 185                 190         


Pro Gly Ile Arg Leu Asn Pro Thr Gln Gln Ser Ala Gly Arg Arg Ala 
        195                 200                 205             


Glu Leu Ser Asn Ala Thr Ala Phe Glu Thr Arg Leu Arg Gln Glu Asp 
    210                 215                 220                 


Val Leu Trp Glu Leu Arg Cys Ile Ala Asp Val Gln Gly Leu Pro Glu 
225                 230                 235                 240 


Asp Val Val Ser Asn Val Ile Asp Ala Val Phe Cys Gln Lys Arg Pro 
                245                 250                 255     


Ser Val Pro Ala Glu Arg Ile Gly Arg Asp Pro Leu Asp Pro Ser Gln 
            260                 265                 270         


Leu Arg Ala Ser Arg Ala Cys Leu Glu Phe Gln Glu Tyr Arg Ile Val 
        275                 280                 285             


Ala Ala Val Ala Asn Leu Arg Ile Arg Asp Gly Ser Gly Ser Arg Pro 
    290                 295                 300                 


Leu Ser Leu Glu Glu Arg Asn Ala Val Ile Glu Ala Leu Leu Ala Gln 
305                 310                 315                 320 


Thr Glu Arg Ser Leu Thr Trp Ser Asp Ile Ala Leu Glu Ile Leu Lys 
                325                 330                 335     


Leu Pro Asn Glu Ser Asp Leu Thr Ser Val Pro Glu Glu Asp Gly Pro 
            340                 345                 350         


Ser Ser Leu Ala Tyr Ser Gln Phe Ala Pro Phe Asp Glu Thr Ser Ala 
        355                 360                 365             


Arg Ile Ala Glu Phe Ile Ala Lys Asn Arg Arg Lys Ile Pro Thr Phe 
    370                 375                 380                 


Ala Gln Trp Trp Gln Glu Gln Asp Arg Thr Ser Arg Ser Asp Leu Val 
385                 390                 395                 400 


Ala Ala Leu Ala Asp Asn Ser Ile Ala Gly Glu Glu Glu Gln Glu Leu 
                405                 410                 415     


Leu Val His Leu Pro Asp Ala Glu Leu Glu Ala Leu Glu Gly Leu Ala 
            420                 425                 430         


Leu Pro Ser Gly Arg Val Ala Tyr Ser Arg Leu Thr Leu Ser Gly Leu 
        435                 440                 445             


Thr Arg Val Met Arg Asp Asp Gly Val Asp Val His Asn Ala Arg Lys 
    450                 455                 460                 


Thr Cys Phe Gly Val Asp Asp Asn Trp Arg Pro Pro Leu Pro Ala Leu 
465                 470                 475                 480 


His Glu Ala Thr Gly His Pro Val Val Asp Arg Asn Leu Ala Ile Leu 
                485                 490                 495     


Arg Lys Phe Leu Ser Ser Ala Thr Met Arg Trp Gly Pro Pro Gln Ser 
            500                 505                 510         


Ile Val Val Glu Leu Ala Arg Gly Ala Ser Glu Ser Arg Glu Arg Gln 
        515                 520                 525             


Ala Glu Glu Glu Ala Ala Arg Arg Ala His Arg Lys Ala Asn Asp Arg 
    530                 535                 540                 


Ile Arg Ala Glu Leu Arg Ala Ser Gly Leu Ser Asp Pro Ser Pro Ala 
545                 550                 555                 560 


Asp Leu Val Arg Ala Arg Leu Leu Glu Leu Tyr Asp Cys His Cys Met 
                565                 570                 575     


Tyr Cys Gly Ala Pro Ile Ser Trp Glu Asn Ser Glu Leu Asp His Ile 
            580                 585                 590         


Val Pro Arg Thr Asp Gly Gly Ser Asn Arg His Glu Asn Leu Ala Ile 
        595                 600                 605             


Thr Cys Gly Ala Cys Asn Lys Glu Lys Gly Arg Arg Pro Phe Ala Ser 
    610                 615                 620                 


Trp Ala Glu Thr Ser Asn Arg Val Gln Leu Arg Asp Val Ile Asp Arg 
625                 630                 635                 640 


Val Gln Lys Leu Lys Tyr Ser Gly Asn Met Tyr Trp Thr Arg Asp Glu 
                645                 650                 655     


Phe Ser Arg Tyr Lys Lys Ser Val Val Ala Arg Leu Lys Arg Arg Thr 
            660                 665                 670         


Ser Asp Pro Glu Val Ile Gln Ser Ile Glu Ser Thr Gly Tyr Ala Ala 
        675                 680                 685             


Val Ala Leu Arg Asp Arg Leu Leu Ser Tyr Gly Glu Lys Asn Gly Val 
    690                 695                 700                 


Ala Gln Val Ala Val Phe Arg Gly Gly Val Thr Ala Glu Ala Arg Arg 
705                 710                 715                 720 


Trp Leu Asp Ile Ser Ile Glu Arg Leu Phe Ser Arg Val Ala Ile Phe 
                725                 730                 735     


Ala Gln Ser Thr Ser Thr Lys Arg Leu Asp Arg Arg His His Ala Val 
            740                 745                 750         


Asp Ala Val Val Leu Thr Thr Leu Thr Pro Gly Val Ala Lys Thr Leu 
        755                 760                 765             


Ala Asp Ala Arg Ser Arg Arg Val Ser Ala Glu Phe Trp Arg Arg Pro 
    770                 775                 780                 


Ser Asp Val Asn Arg His Ser Thr Glu Glu Pro Gln Ser Pro Ala Tyr 
785                 790                 795                 800 


Arg Gln Trp Lys Glu Ser Cys Ser Gly Leu Gly Asp Leu Leu Ile Ser 
                805                 810                 815     


Thr Ala Ala Arg Asp Ser Ile Ala Val Ala Ala Pro Leu Arg Leu Arg 
            820                 825                 830         


Pro Thr Gly Ala Leu His Glu Glu Thr Leu Arg Ala Phe Ser Glu His 
        835                 840                 845             


Thr Val Gly Ala Ala Trp Lys Gly Ala Glu Leu Arg Arg Ile Val Glu 
    850                 855                 860                 


Pro Glu Val Tyr Ala Ala Phe Leu Ala Leu Thr Asp Pro Gly Gly Arg 
865                 870                 875                 880 


Phe Leu Lys Val Ser Pro Ser Glu Asp Val Leu Pro Ala Asp Glu Asn 
                885                 890                 895     


Arg His Ile Val Leu Ser Asp Arg Val Leu Gly Pro Arg Asp Arg Val 
            900                 905                 910         


Lys Leu Phe Pro Asp Asp Arg Gly Ser Ile Arg Val Arg Gly Gly Ala 
        915                 920                 925             


Ala Tyr Ile Ala Ser Phe His His Ala Arg Val Phe Arg Trp Gly Ser 
    930                 935                 940                 


Ser His Ser Pro Ser Phe Ala Leu Leu Arg Val Ser Leu Ala Asp Leu 
945                 950                 955                 960 


Ala Val Ala Gly Leu Leu Arg Asp Gly Val Asp Val Phe Thr Ala Glu 
                965                 970                 975     


Leu Pro Pro Trp Thr Pro Ala Trp Arg Tyr Ala Ser Ile Ala Leu Val 
            980                 985                 990         


Lys Ala Val Glu Ser Gly Asp Ala  Lys Gln Val Gly Trp  Leu Val Pro 
        995                 1000                 1005             


Gly Asp  Glu Leu Asp Phe Gly  Pro Glu Gly Val Thr  Thr Ala Ala 
    1010                 1015                 1020             


Gly Asp  Leu Ser Met Phe Leu  Lys Tyr Phe Pro Glu  Arg His Trp 
    1025                 1030                 1035             


Val Val  Thr Gly Phe Glu Asp  Asp Lys Arg Ile Asn  Leu Lys Pro 
    1040                 1045                 1050             


Ala Phe  Leu Ser Ala Glu Gln  Ala Glu Val Leu Arg  Thr Glu Arg 
    1055                 1060                 1065             


Ser Asp  Arg Pro Asp Thr Leu  Thr Glu Ala Gly Glu  Ile Leu Ala 
    1070                 1075                 1080             


Gln Phe  Phe Pro Arg Cys Trp  Arg Ala Thr Val Ala  Lys Val Leu 
    1085                 1090                 1095             


Cys His  Pro Gly Leu Thr Val  Ile Arg Arg Thr Ala  Leu Gly Gln 
    1100                 1105                 1110             


Pro Arg  Trp Arg Arg Gly His  Leu Pro Tyr Ser Trp  Arg Pro Trp 
    1115                 1120                 1125             


Ser Ala  Asp Pro Trp Ser Gly  Gly Thr Pro 
    1130                 1135             


<210> 43
<211> 1045
<212> PRT
<213> Acidovorax avenae

<400> 43
Met Gln Lys Glu Lys Pro Leu Ala Tyr Arg Leu Ala Leu Asp Leu Gly 
1               5                   10                  15      


Ser Thr Ser Leu Gly Trp Ala Val Leu Arg Leu Ser Ala Pro Gly Glu 
            20                  25                  30          


Pro Ser Ala Val Ile Arg Ala Gly Ser Arg Ile Phe Ser Asp Gly Arg 
        35                  40                  45              


Asn Pro Lys Asp Gly Ser Ser Leu Ala Val Thr Arg Arg Ala Ala Arg 
    50                  55                  60                  


Ala Met Arg Arg Arg Arg Asp Arg Leu Leu Lys Arg Lys Ala Arg Met 
65                  70                  75                  80  


Leu Ala Ala Leu Glu Arg His Gly Phe Phe Pro Gln Asp Glu Ala Ala 
                85                  90                  95      


Arg Lys Ala Leu Glu Lys Leu Asn Pro Tyr Gly Leu Arg Ala Arg Gly 
            100                 105                 110         


Leu Glu Ser Ala Leu Lys Pro Glu Glu Phe Gly Arg Ala Leu Phe His 
        115                 120                 125             


Leu Asn Gln Arg Arg Gly Phe Gln Ser Asn Arg Lys Thr Asp Arg Lys 
    130                 135                 140                 


Asp Ser Asp Ser Gly Ala Leu Lys Gln Ala Ile Gly Thr Leu Arg Ala 
145                 150                 155                 160 


Gln Met His Glu Ser Gly Cys Arg Thr Val Gly Glu Trp Phe Trp Lys 
                165                 170                 175     


Val Arg Met Glu Arg Lys Pro Glu Gly Val Lys Gly Gln Gly Val Arg 
            180                 185                 190         


Ala Arg Tyr Arg Glu Thr Pro Phe Thr Thr Asp Glu Gly Lys Lys Arg 
        195                 200                 205             


Ile Asp Lys Arg Tyr Asp Leu Tyr Val Asp Arg Ala Met Val Ala Gln 
    210                 215                 220                 


Glu Phe Asp Ala Leu Trp Ala Ala Gln Ala Thr Phe Ala Pro Ala Leu 
225                 230                 235                 240 


Phe Asn Glu Ala Ala Arg Ala Glu Leu Arg Asp Ile Leu Leu His Gln 
                245                 250                 255     


Arg Lys Leu Arg Pro Val Gln Pro Gly Arg Cys Thr Leu Val Pro Glu 
            260                 265                 270         


Glu Pro Arg Ala Leu Leu Ala Leu Pro Ser Thr Gln Arg Phe Arg Ile 
        275                 280                 285             


Tyr Gln Glu Val Asn His Leu Arg Val Leu His Asp Glu Leu Arg Glu 
    290                 295                 300                 


Glu Ala Leu Thr Leu Ala Gln Arg Asp Gln Ile Val Ala Leu Leu Glu 
305                 310                 315                 320 


Arg Gln Ala Lys Val Thr Phe Thr Ala Met Arg Lys Ala Leu Gly Phe 
                325                 330                 335     


Ser Ala Leu Phe Asn Leu Glu Asp Ala Lys Arg Asp Gly Leu Lys Gly 
            340                 345                 350         


Asn Ala Thr Thr Ala Ala Leu Gly Lys Lys Asp Leu Phe Gly Pro Leu 
        355                 360                 365             


Trp Ala Gly Phe Asp Thr Ala Leu Gln Asp Glu Ile Val Thr Gln Leu 
    370                 375                 380                 


Met Thr Glu Glu Ser Glu Pro Arg Leu Ile Ala Trp Leu Gln Glu His 
385                 390                 395                 400 


Thr Gly Val Asp Glu Ala Arg Ala Gln Ala Ile Ala Asn Ala Gly Leu 
                405                 410                 415     


Pro Glu Gly Tyr Gly Ser Leu Gly Arg Thr Ala Leu Ala Arg Ile Val 
            420                 425                 430         


Pro Glu Leu Gln Arg Asp Val Ile Thr Tyr Asp Lys Ala Val Gln Ala 
        435                 440                 445             


Ala Gly Phe Ala His His Ser Asp Leu Gly Phe Ser Phe Glu His Asp 
    450                 455                 460                 


Ala Asp Glu Val Glu Arg Ile Gly Glu Arg Thr Ile Ala Ser Thr Gly 
465                 470                 475                 480 


Glu Ile Lys Pro Val Phe Ala Phe Lys Gln Leu Pro Tyr Tyr Gly Arg 
                485                 490                 495     


Ala Leu Gln Arg His Val Ala Phe Ala Lys Glu Asn Pro Arg Asn Asp 
            500                 505                 510         


Glu Glu Arg Tyr Gly Lys Ile Ala Asn Pro Thr Val His Ile Gly Leu 
        515                 520                 525             


Asn Gln Val Arg Val Val Val Asn Ala Leu Met Cys Arg Tyr Gly Arg 
    530                 535                 540                 


Pro Thr Glu Val Val Ile Glu Leu Ala Arg Asp Leu Lys Gln Ser Arg 
545                 550                 555                 560 


Glu Gln Lys Leu Glu Ala Gln Gln Arg Gln Ala Asp Asn Gln Lys Arg 
                565                 570                 575     


Asn Ala Arg Ile Arg Arg Ser Ile Ala Glu Val Leu Gly Ile Ser Glu 
            580                 585                 590         


Glu Arg Val Arg Thr Leu Asp Ile Gln Lys Trp Ile Leu Trp Glu Glu 
        595                 600                 605             


Leu Ser His Asp Ala Ala Asp Arg Arg Cys Pro Tyr Ser Gly Val Gln 
    610                 615                 620                 


Ile Ser Ala Ser Met Leu Leu Gly Glu Arg Val Glu Ile Glu His Ile 
625                 630                 635                 640 


Leu Pro Phe Ser Met Thr Leu Asp Asp Ser Leu Asn Asn Arg Thr Val 
                645                 650                 655     


Ala Leu Arg Glu Ala Asn Arg Ile Lys Arg Asn Arg Thr Pro Trp Asp 
            660                 665                 670         


Ala Arg Thr Asp Phe Glu Ala His Gly Trp Ser Tyr Asp Gly Ile Leu 
        675                 680                 685             


Gln Arg Ala Glu Arg Met Pro Gln Arg Lys Arg His Arg Phe Ala Pro 
    690                 695                 700                 


Asp Gly Tyr Glu Arg Trp Leu Gly Glu Asp Lys Asp Phe Leu Ala Arg 
705                 710                 715                 720 


Ala Leu Asn Asp Thr Arg Tyr Leu Ser Arg Val Ala Ala Glu Tyr Leu 
                725                 730                 735     


Arg Leu Val Cys Pro Gly Ser Ala Thr Arg Val Ile Pro Gly Gln Met 
            740                 745                 750         


Thr Ala Leu Leu Arg Gly Lys Phe Gly Leu Asn Asp Val Leu Gly Leu 
        755                 760                 765             


Asp Gly Glu Lys Asn Arg Asn Asp His Arg His His Ala Val Asp Ala 
    770                 775                 780                 


Cys Val Ile Gly Val Thr Asp Gln Arg Met Met Gln Arg Phe Ala Gln 
785                 790                 795                 800 


Ala Asn Ala Gln Ala Arg Glu Asp Gly Leu Thr Arg Leu Val Glu Asp 
                805                 810                 815     


Met Pro Leu Pro Trp Pro Thr Tyr Arg Ala His Val Glu Arg Ala Val 
            820                 825                 830         


Arg His Ile Trp Val Ser His Lys Pro Asp His Gly Phe Glu Gly Ala 
        835                 840                 845             


Met Met Glu Glu Thr Ser Tyr Gly Ile Leu Arg Asp Gly Thr Ile Lys 
    850                 855                 860                 


Gln Arg Arg Lys Ala Asp Gly Ser Ala Gly Arg Glu Ile Ser Arg Leu 
865                 870                 875                 880 


Ile Arg Ile Thr Glu Pro Ser Gln Pro Gln Arg His Gly Val Asp Ala 
                885                 890                 895     


Glu Gly Arg Pro Leu Pro Tyr Lys Gly Tyr Val Gly Gly Ser Asn Tyr 
            900                 905                 910         


Cys Leu Glu Ile Thr Val Asn Asp Lys Gly Lys Trp Glu Gly Gln Val 
        915                 920                 925             


Ile Ser Thr Phe Asp Ala Tyr Arg Ile Val Arg Glu Gly Gly Leu Arg 
    930                 935                 940                 


Gln Leu Arg His Ser Thr Gln Gly Gln Asn Gly Gln Ala Leu Ala Met 
945                 950                 955                 960 


Arg Leu Val Ile Gly Asp Ser Val Arg Leu Glu Val Asp Glu Gln Glu 
                965                 970                 975     


Arg Val Met Arg Ile Val Lys Ile Asn Gly Asn Asn Gly Gln Val Phe 
            980                 985                 990         


Met Ala Pro Val His Glu Ala Asn  Val Asp Ala Arg Asn  Ser Asp Lys 
        995                 1000                 1005             


Asn Glu  Ala Phe Ala Tyr Thr  Ser Lys Ile Ala Gly  Ser Phe Gln 
    1010                 1015                 1020             


Lys Thr  Lys Ala Arg Gln Val  Thr Ile Ser Pro Ile  Gly Glu Leu 
    1025                 1030                 1035             


Arg Asp  Pro Gly Phe Lys Gly  
    1040                 1045 


<210> 44
<211> 1131
<212> PRT
<213> Acidovorax ebreus

<400> 44
Met Ala Gln His Val Phe Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Trp Ala Ile Leu Gly Glu Gln Arg Ile Ile Asp Leu Gly Val Arg Cys 
            20                  25                  30          


Phe Asp Lys Ala Glu Thr Ala Lys Glu Gly Asp Pro Leu Asn Leu Thr 
        35                  40                  45              


Arg Arg Gln Ala Arg Leu Leu Arg Arg Arg Leu Tyr Arg Arg Ala Trp 
    50                  55                  60                  


Arg Leu Thr Gln Leu Ser Arg Leu Leu Lys Arg Lys Gly Leu Ile Ala 
65                  70                  75                  80  


Asp Ala Lys Leu Phe Ala Lys Ala Pro Ser Tyr Gly Asp Ser Ala Trp 
                85                  90                  95      


Glu Leu Arg Arg Gln Gly Leu Asp Arg Leu Leu Thr Pro Leu Glu Trp 
            100                 105                 110         


Ala Arg Val Ile Tyr His Gln Cys Lys His Arg Gly Phe His Trp Thr 
        115                 120                 125             


Ser Lys Ala Glu Glu Ala Lys Ala Asp Ser Asp Ala Glu Gly Gly Arg 
    130                 135                 140                 


Val Lys Gln Gly Leu Ala His Thr Lys Ala Leu Met Gln Ala Lys Asn 
145                 150                 155                 160 


Tyr Arg Ser Ala Ala Glu Met Val Leu Ala Glu Phe Pro Asp Ala Gln 
                165                 170                 175     


Arg Asn Lys Arg Gly Gln Tyr Asp Lys Ala Leu Ser Arg Val Leu Leu 
            180                 185                 190         


Gly Glu Glu Leu Ala Leu Leu Phe Ala Thr Gln Arg Arg Leu Gly Asn 
        195                 200                 205             


Pro His Ala Ser Asp Phe Phe Glu Lys Leu Ile Leu Gly Asp Gly Asp 
    210                 215                 220                 


Arg Lys Ser Gly Leu Phe Trp Gln Gln Lys Pro Ala Leu Ser Gly Ala 
225                 230                 235                 240 


Asp Leu Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Lys Gly Glu Tyr 
                245                 250                 255     


Arg Ala Pro Lys Ala Ser Phe Ser Val Glu Arg His Val Trp Leu Thr 
            260                 265                 270         


Arg Leu Asn Asn Leu Arg Ile Val Val Asp Gly Arg Ser Arg Pro Leu 
        275                 280                 285             


Asn Glu Ala Glu Arg Gln Ala Ala Leu Leu Leu Pro Tyr Gln Thr Glu 
    290                 295                 300                 


Thr Ser Lys Tyr Lys Thr Leu Lys Asn Ala Phe Ile Lys Ala Gly Leu 
305                 310                 315                 320 


Trp Gly Asp Gly Val Arg Phe Gly Gly Leu Ala Tyr Pro Ser Gln Ala 
                325                 330                 335     


Gln Ile Asp Ala Glu Lys Thr Lys Asp Pro Glu Asp Gln Phe Leu Val 
            340                 345                 350         


Lys Leu Pro Ala Trp His Glu Leu Arg Lys Ala Phe Lys Ala Ala Gly 
        355                 360                 365             


His Glu Ala Leu Trp Gln Gln Ile Ser Thr Pro Ala Leu Asp Gly Asp 
    370                 375                 380                 


Pro Thr Leu Leu Asp Gln Ile Ala Thr Val Leu Ser Val Tyr Lys Asp 
385                 390                 395                 400 


Gly Ala Glu Val Val Gln Gln Leu Arg Gln Leu Ala Leu Pro Glu Pro 
                405                 410                 415     


Ala Ala Ser Ile Ala Val Leu Glu Lys Ile Ser Phe Asp Lys Phe Ser 
            420                 425                 430         


Ser Leu Ser Leu Lys Ala Leu Arg Arg Ile Val Pro Leu Met Gln Ser 
        435                 440                 445             


Gly Leu Arg Tyr Asp Glu Ala Val Ala Gln Ile Pro Glu Tyr Gly His 
    450                 455                 460                 


His Ser Gln Arg Ile Glu Pro Gly Ala Ala Lys His Leu Tyr Leu Pro 
465                 470                 475                 480 


Pro Phe Tyr Glu Ala Gln Arg Lys Tyr Ala Gly Lys Gly Asp His Ile 
                485                 490                 495     


Gly Ser Met Gln Phe Arg Asp Asp Ala Asp Ile Pro Arg Asn Pro Val 
            500                 505                 510         


Val Leu Arg Ala Leu Asn Gln Ala Arg Lys Val Val Asn Ala Leu Ile 
        515                 520                 525             


Arg Glu Tyr Gly Ser Pro Ile Ala Val Asn Ile Glu Met Ala Arg Asp 
    530                 535                 540                 


Leu Ser Arg Pro Leu Asp Glu Arg Asn Lys Val Lys Arg Ala Gln Glu 
545                 550                 555                 560 


Glu Phe Arg Asp Arg Asn Asp Arg Ala Arg Ser Glu Phe Glu Arg Asp 
                565                 570                 575     


Phe Gly Tyr Lys Pro Lys Ala Ala Ala Phe Glu Lys Trp Met Leu Tyr 
            580                 585                 590         


Arg Glu Gln Leu Gly Gln Cys Ala Tyr Ser Gln Gln Pro Leu Asp Ile 
        595                 600                 605             


Gln Arg Val Leu Asp Asp His Asn Tyr Ala Gln Val Asp His Ala Leu 
    610                 615                 620                 


Pro Tyr Ser Arg Ser Tyr Asp Asp Ser Lys Asn Asn Lys Val Leu Val 
625                 630                 635                 640 


Leu Thr His Glu Asn Gln Asn Lys Gly Asn Arg Thr Ala Phe Glu Tyr 
                645                 650                 655     


Leu Thr Ser Phe Pro Asp Gly Glu Asp Gly Glu Arg Trp Arg Thr Phe 
            660                 665                 670         


Val Ala Trp Val Gln Gly Asn Lys Ala Tyr Arg Met Ala Lys Arg Asn 
        675                 680                 685             


Arg Leu Leu Arg Lys Asn Tyr Gly Val Asp Glu Ser Lys Gly Phe Ile 
    690                 695                 700                 


Asp Arg Asn Leu Asn Asp Thr Arg Tyr Ile Cys Lys Phe Phe Lys Asn 
705                 710                 715                 720 


Tyr Val Glu Glu His Leu Gln Leu Ala Ala Arg Ala Asp Gly Asp Thr 
                725                 730                 735     


Ala Arg Arg Cys Val Val Val Asn Gly Gln Leu Thr Ala Phe Leu Arg 
            740                 745                 750         


Ala Arg Trp Gly Leu Thr Lys Val Arg Gly Asp Ser Asp Arg His His 
        755                 760                 765             


Ala Leu Asp Ala Ala Val Val Ala Ala Cys Thr His Gly Met Val Lys 
    770                 775                 780                 


Ala Leu Ala Asp Tyr Ser Arg Arg Lys Glu Ile Ser Phe Leu Gln Glu 
785                 790                 795                 800 


Gly Phe Pro Asp Pro Glu Thr Gly Glu Ile Leu Asn Pro Ala Ala Phe 
                805                 810                 815     


Asp Arg Ala Arg Gln His Phe Pro Glu Pro Trp Thr His Phe Ala His 
            820                 825                 830         


Glu Leu Lys Ala Arg Leu Phe Thr Asp Asp Leu Ala Ala Leu Arg Glu 
        835                 840                 845             


Asp Met Gln Arg Leu Gly Ser Tyr Thr Thr Glu Asp Leu Gly Arg Leu 
    850                 855                 860                 


Arg Thr Leu Phe Val Ser Arg Ala Pro Gln Arg Arg Ser Gly Gly Ala 
865                 870                 875                 880 


Val His Lys Glu Thr Ile Tyr Ala Gln Pro Glu Ser Leu Lys Gln Gln 
                885                 890                 895     


Gly Gly Val Ile Glu Lys Ile Leu Leu Thr Ser Leu Lys Leu Gln Asp 
            900                 905                 910         


Phe Asp Lys Leu Leu Asn Pro Glu Ser Asn Asp His Phe Val Glu Pro 
        915                 920                 925             


His Arg Asn Glu Arg Leu Tyr Ala Ala Ile Arg Gln Arg Leu Glu Gln 
    930                 935                 940                 


Phe Gly Gly Arg Ala Asp Lys Ala Phe Gly Pro Asp Asn Leu Phe His 
945                 950                 955                 960 


Lys Pro Asp Lys Asn Asn Gln Pro Thr Gly Pro Val Val Arg Ser Ile 
                965                 970                 975     


Lys Leu Val Arg Gly Lys Gln Thr Gly Ile Pro Ile Arg Gly Gly Leu 
            980                 985                 990         


Ala Lys Asn Asp Ser Met Leu Arg  Val Asp Ile Phe Thr  Lys Ala Gly 
        995                 1000                 1005             


Lys Phe  His Leu Val Pro Val  Tyr Val His His Arg  Val Thr Gly 
    1010                 1015                 1020             


Leu Pro  Asn Arg Ala Ile Val  Ala Phe Lys Asp Glu  Asp Glu Trp 
    1025                 1030                 1035             


Thr Leu  Ile Asp Glu Ser Phe  Ala Phe Leu Phe Ser  Val Tyr Pro 
    1040                 1045                 1050             


Asn Asp  Tyr Val Lys Val Thr  Leu Lys Lys Glu Gln  Gln Ser Gly 
    1055                 1060                 1065             


Tyr Tyr  Ser Gly Ala Asp Arg  Ser Thr Gly Ala Met  Asn Leu Trp 
    1070                 1075                 1080             


Ala His  Asp Arg Ala Ala Ser  Val Gly Lys Asp Gly  Leu Ile Arg 
    1085                 1090                 1095             


Gly Ile  Gly Val Lys Thr Ala  Leu Ser Val Glu Lys  Phe Asn Val 
    1100                 1105                 1110             


Asp Val  Leu Gly Arg Ile Tyr  Leu Ala Pro Pro Glu  Thr Arg Ser 
    1115                 1120                 1125             


Gly Leu  Ala 
    1130     


<210> 45
<211> 1056
<212> PRT
<213> Actinobacillus minor


<220>
<223> Actinobacillus minor NM305

<400> 45
Met Lys Ala Leu Asn Tyr Ile Leu Gly Leu Asp Leu Gly Ile Ala Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Val Glu Ile Asp Gln Asn Glu Leu Pro Ile Arg 
            20                  25                  30          


Leu Ile Asp Leu Gly Val Arg Thr Phe Glu Arg Ala Glu Val Pro Lys 
        35                  40                  45              


Thr Gly Asp Ser Leu Ala Leu Ala Arg Arg Leu Ala Arg Ser Ser Arg 
    50                  55                  60                  


Arg Leu Val Arg Arg Arg Ala Val Arg Leu Leu Lys Ala Lys Arg Leu 
65                  70                  75                  80  


Leu Lys Gln Glu Gly Ile Leu Gln Ala Asp Asp Phe His Ser Ser His 
                85                  90                  95      


Leu Lys Pro Leu Pro Asn Asn Pro Trp Glu Leu Arg Val Lys Gly Leu 
            100                 105                 110         


Asn His Leu Leu Asp Arg Lys Glu Trp Ala Ala Val Leu Leu His Leu 
        115                 120                 125             


Leu Lys His Arg Gly Tyr Leu Ser Gln Arg Lys Asn Glu Ser Lys Thr 
    130                 135                 140                 


Asp Asn Lys Glu Leu Gly Ala Leu Leu Lys Gly Val Ser Glu Asn Arg 
145                 150                 155                 160 


Gln Leu Leu Gln Ala Gln Ala Phe Ser Thr Pro Ala Glu Ile Ala Ile 
                165                 170                 175     


Lys Lys Phe Gln Gln Glu Glu Gly His Ile Arg Asn Gln Arg Gly Ala 
            180                 185                 190         


Tyr Ser His Thr Phe Asp Arg Asn Asp Leu Leu Ala Glu Leu Arg Leu 
        195                 200                 205             


Leu Phe Gln Lys Gln Arg Glu Phe Asn Asn Pro Tyr Thr Ser Gln Ser 
    210                 215                 220                 


Leu Glu Gln Ala Ile Ala Glu Leu Leu Met Trp Gln Lys Pro Ala Leu 
225                 230                 235                 240 


Ser Gly Glu Ala Ile Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Pro 
                245                 250                 255     


Ser Glu Tyr Lys Ala Pro Lys Asn Ser Tyr Ser Ala Glu Tyr Phe Val 
            260                 265                 270         


Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile Leu Glu Asn Gly Ala Asp 
        275                 280                 285             


Arg Gly Leu Thr Ala Glu Glu Arg Gln Leu Leu Ile Asn Gln Pro Phe 
    290                 295                 300                 


Glu Lys Ala Lys Phe Thr Tyr Ala Gln Ala Arg Lys Leu Leu Glu Leu 
305                 310                 315                 320 


Ser Asp Leu Ala Ile Phe Lys Gly Val Arg Tyr Gly Lys Asp Asn Ala 
                325                 330                 335     


Glu Ser Ala Thr Leu Met Glu Met Lys Ala Trp His Ala Ile Arg Lys 
            340                 345                 350         


Ala Leu Glu Ser Asn Gly Leu Lys Thr Glu Trp Asn Gly Leu Lys Thr 
        355                 360                 365             


Lys Pro Glu Leu Leu Asp Lys Ile Gly Thr Ala Phe Ser Ile Tyr Lys 
    370                 375                 380                 


Thr Asp Glu Asp Ile Ser Gln Tyr Leu Asn Gly Glu Leu Ser Pro Ala 
385                 390                 395                 400 


Val Leu Asn Ala Leu Leu Glu Asn Leu Ser Phe Asp Lys Phe Ile Arg 
                405                 410                 415     


Leu Ser Leu Gln Ser Leu Ala Lys Ile Leu Pro Leu Met Glu Gln Gly 
            420                 425                 430         


Leu Arg Tyr Asp Glu Ala Cys Lys Gln Val Tyr Gly Asp His Tyr Gly 
        435                 440                 445             


Lys Lys Glu Gln Leu Glu Leu Arg Phe Leu Pro Lys Ile Pro Val Glu 
    450                 455                 460                 


Asp Ile Arg Asn Pro Val Val Leu Arg Thr Leu Ser Gln Ala Arg Lys 
465                 470                 475                 480 


Val Ile Asn Gly Val Val Arg Leu Tyr Gly Ser Pro Ala Arg Ile His 
                485                 490                 495     


Ile Glu Thr Gly Arg Glu Val Gly Lys Ser Phe Ser Glu Arg Arg Asp 
            500                 505                 510         


Ile Ser Lys Arg Gln Glu Glu Asn Arg Asn Glu Arg Gln Arg Ala Val 
        515                 520                 525             


Glu Lys Phe Lys Glu Phe Phe Pro His Phe Val Gly Glu Pro Lys Ala 
    530                 535                 540                 


Lys Asp Ile Leu Lys Met Arg Leu Tyr Glu Gln Gln His Gly Lys Cys 
545                 550                 555                 560 


Leu Tyr Ser Gly Lys Glu Leu Asp Leu Asn Arg Leu Leu Glu Lys Gly 
                565                 570                 575     


Tyr Val Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp 
            580                 585                 590         


Ser Phe Asn Asn Lys Val Leu Val Leu Ala Ser Glu Asn Gln Asn Lys 
        595                 600                 605             


Gly Asn Gln Thr Pro Tyr Glu Trp Leu Asn Gly Lys Glu Asn Ala Glu 
    610                 615                 620                 


Arg Trp Lys Leu Phe Gln Ala Leu Val Asn Gly Ser Arg Phe Pro Tyr 
625                 630                 635                 640 


Ser Lys Lys Gln Arg Ile Leu Thr Lys Tyr Leu Asp Glu Asp Gly Phe 
                645                 650                 655     


Arg Glu Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys 
            660                 665                 670         


Asn Phe Ile Glu Asp Asn Met Gln Leu Val Gly Gln Gly Lys Lys Arg 
        675                 680                 685             


Val Phe Ala Ser Asn Gly Gln Ile Thr Ala Leu Leu Arg Arg Ser Trp 
    690                 695                 700                 


Gly Ile Gln Lys Val Arg Glu Asp Asn Asp Arg His His Ala Val Asp 
705                 710                 715                 720 


Ala Val Val Val Ala Cys Ser Thr Arg Ala Leu Gln Lys Lys Ile Thr 
                725                 730                 735     


Asp Tyr Val Arg Tyr Lys Glu Met Asn Val Phe Thr Gly Glu Lys Ile 
            740                 745                 750         


Asp Gln Glu Thr Gly Glu Ile Ile Lys Phe His Phe Pro Glu Pro Trp 
        755                 760                 765             


Lys Phe Phe Arg Gln Glu Val Glu Ile Arg Val Phe Ser Glu Thr Pro 
    770                 775                 780                 


Ala Glu Asp Val Val Ile Ala Leu Pro Asp Arg Pro Gln Ala Asn His 
785                 790                 795                 800 


Glu Phe Ile Gln Pro Leu Phe Val Ser Arg Ala Pro Thr Arg Lys Met 
                805                 810                 815     


Thr Gly Gln Gly His Met Glu Thr Ile Lys Ser Ala Lys Arg Leu Ala 
            820                 825                 830         


Glu Gly Leu Ser Val Ser Arg Val Pro Leu Thr Gln Leu Lys Leu Lys 
        835                 840                 845             


Asp Leu Glu Asn Met Val Asn Arg Glu Arg Glu Lys Ala Leu Tyr Glu 
    850                 855                 860                 


Ala Leu Lys Val Arg Leu Glu Lys Phe Asn Asn Asp Pro Ala Lys Ala 
865                 870                 875                 880 


Phe Ala Asp Pro Phe Tyr Lys Lys Gly Gly Gln Gln Val Lys Ala Val 
                885                 890                 895     


Arg Val Glu Gln Val Gln Lys Ser Gly Val Leu Val Arg Gln Glu Asn 
            900                 905                 910         


Gly Val Ala Asp Asn Ala Ser Met Val Arg Val Asp Val Phe Ile Lys 
        915                 920                 925             


Gly Gly Lys Tyr Phe Leu Val Pro Ile Tyr Thr Trp Gln Val Ala Lys 
    930                 935                 940                 


Gly Ile Leu Pro Asn Arg Ala Ala Thr Gln Gly Lys Glu Glu Glu Tyr 
945                 950                 955                 960 


Trp Asp Ile Met Asp Glu Thr Ala Ile Phe Gln Phe Ser Leu Tyr Gln 
                965                 970                 975     


Asn Asp Leu Ile Lys Leu Val Thr Lys Lys Lys Thr Ile Phe Gly Tyr 
            980                 985                 990         


Phe Asn Gly Leu Asn Arg Ala Thr  Ser Asn Ile Asn Ile  Lys Glu His 
        995                 1000                 1005             


Asp Leu  Asp Lys Ser Lys Gly  Lys Asp Gly Ile Tyr  Leu Glu Val 
    1010                 1015                 1020             


Gly Val  Lys Leu Ala Leu Ser  Leu Glu Lys Tyr Gln  Val Asp Glu 
    1025                 1030                 1035             


Leu Gly  Lys Asn Ile Gln Pro  Cys Arg Ser Met Lys  Lys Arg Pro 
    1040                 1045                 1050             


Pro Val  Arg 
    1055     


<210> 46
<211> 1054
<212> PRT
<213> Actinobacillus pleuropneumoniae


<220>
<223> Actinobacillus pleuropneumoniae serovar 10 str. D13039

<400> 46
Met Lys Leu Thr Pro Leu Asn Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Val Val Glu Ile Asp Glu Gln Glu Asn Pro 
            20                  25                  30          


Leu Gly Leu Ile Asp Val Gly Val Arg Thr Phe Asp Arg Ala Glu Val 
        35                  40                  45              


Ala Lys Thr Gly Glu Ser Leu Ala Leu Ala Arg Arg Leu Ala Arg Ser 
    50                  55                  60                  


Ser Arg Arg Leu Val Lys Arg Arg Ala Asp Arg Ile Lys Lys Val Lys 
65                  70                  75                  80  


Arg Leu Leu Lys Ser Glu Asn Ile Leu Leu Ser Ala Asp Glu Gln Leu 
                85                  90                  95      


Pro Asn Asp Val Trp Gln Leu Arg Val Lys Gly Leu Asp Gln Lys Leu 
            100                 105                 110         


Glu Arg Gln Glu Trp Ala Ala Val Leu Leu His Leu Leu Lys His Arg 
        115                 120                 125             


Gly Tyr Leu Ser Gln Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu 
    130                 135                 140                 


Leu Gly Ala Leu Arg Ser Gly Val Ala Ala Asn His Gln Ile Leu Gln 
145                 150                 155                 160 


Ser Ala Glu Tyr Arg Thr Pro Ala Glu Ile Ala Val Lys Lys Phe His 
                165                 170                 175     


Val Glu Glu Gly His Ile Arg Asn Gln Arg Gly Ala Tyr Thr His Thr 
            180                 185                 190         


Phe Ser Arg Leu Asp Leu Leu Ala Glu Ile Glu Leu Leu Phe Thr Arg 
        195                 200                 205             


Gln Thr Glu Leu Gly Asn Pro His Thr Ser Ala Lys Leu Leu Glu Asn 
    210                 215                 220                 


Leu Thr Ala Leu Leu Met Trp Gln Lys Pro Ala Leu Ala Gly Glu Ala 
225                 230                 235                 240 


Ile Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Pro Thr Glu Tyr Lys 
                245                 250                 255     


Ala Ala Lys Asn Ser Tyr Ser Ala Glu Arg Phe Val Trp Leu Thr Lys 
            260                 265                 270         


Leu Asn Asn Leu Arg Ile Leu Glu Gln Gly Ala Glu Arg Ala Leu Thr 
        275                 280                 285             


Asp Asn Glu Arg Phe Ala Leu Leu Asp Gln Pro Tyr Glu Lys Ala Lys 
    290                 295                 300                 


Phe Thr Tyr Ala Gln Ala Arg Thr Met Leu Ala Leu Pro Asp Glu Ala 
305                 310                 315                 320 


Ile Phe Lys Gly Val Arg Tyr Gln Gly Glu Asp Lys Lys Ala Val Glu 
                325                 330                 335     


Thr Lys Thr Ile Leu Met Glu Met Lys Ala Tyr His Gln Ile Arg Lys 
            340                 345                 350         


Ala Leu Glu Asn Ala Asp Leu Lys Ala Glu Trp Asn Glu Leu Lys Asn 
        355                 360                 365             


Asn Ser Glu Leu Leu Asp Asp Ile Gly Thr Ala Phe Ser Leu His Lys 
    370                 375                 380                 


Thr Asp Glu Asp Ile Cys Arg Tyr Leu Asp Gly Lys Leu Ser Glu Ser 
385                 390                 395                 400 


Ile Leu Asn Ala Leu Leu Glu Asn Leu Asn Phe Asp Lys Phe Ile Gln 
                405                 410                 415     


Leu Ser Leu Lys Ala Leu Gln Gln Ile Leu Pro Leu Met Leu Gln Gly 
            420                 425                 430         


Gln Arg Tyr Asp Glu Ala Val Ser Ala Ile Tyr Gly Asp His Tyr Gly 
        435                 440                 445             


Lys Lys Ser Ala Glu Ile Asn Arg Leu Leu Pro Thr Ile Pro Ala Asp 
    450                 455                 460                 


Glu Ile Arg Asn Pro Val Val Leu Arg Thr Leu Thr Gln Ala Arg Lys 
465                 470                 475                 480 


Val Ile Asn Ala Val Val Arg Leu Tyr Gly Ser Pro Ala Arg Ile His 
                485                 490                 495     


Ile Glu Thr Gly Arg Glu Val Gly Lys Ser Tyr Gln Asp Arg Lys Lys 
            500                 505                 510         


Leu Glu Lys Gln Gln Glu Asp Asn Arg Lys His Arg Glu Ser Ala Val 
        515                 520                 525             


Gln Lys Phe Lys Glu Tyr Phe Pro Asn Phe Val Gly Glu Pro Lys Gly 
    530                 535                 540                 


Lys Asp Ile Leu Lys Met Arg Leu Tyr Glu Leu Gln Gln Ala Lys Cys 
545                 550                 555                 560 


Leu Tyr Ser Gly Lys Ser Leu Glu Leu His Arg Leu Leu Glu Lys Gly 
                565                 570                 575     


Tyr Val Glu Val Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp 
            580                 585                 590         


Ser Phe Asn Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gln Asn Lys 
        595                 600                 605             


Gly Asn Leu Thr Pro Tyr Glu Trp Leu Asp Gly Lys Asn Asn Ser Glu 
    610                 615                 620                 


Pro Trp Gln Asn Phe Val Ala Arg Val Gln Thr Ser Gly Phe Ser His 
625                 630                 635                 640 


Thr Lys Lys Gln Arg Ile Leu Ser His Lys Leu Asp Glu Lys Gly Phe 
                645                 650                 655     


Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Val Val Arg Phe Leu Cys 
            660                 665                 670         


Asn Phe Ile Ala Asp Asn Met Leu Leu Thr Gly Lys Gly Lys Arg Lys 
        675                 680                 685             


Val Phe Ala Ser Asn Gly Gln Ile Thr Ala Leu Leu Arg Gly Arg Trp 
    690                 695                 700                 


Gly Leu Gln Lys Val Arg Asp Asp Asn Asp Arg His His Ala Leu Asp 
705                 710                 715                 720 


Ala Val Val Val Ala Cys Ser Thr Val Ala Met Gln Gln Lys Ile Thr 
                725                 730                 735     


Arg Phe Val Arg Tyr Glu Glu Gly Asn Val Phe Ser Gly Glu Arg Ile 
            740                 745                 750         


Asp Arg Glu Thr Gly Glu Ile Ile Pro Leu His Phe Pro Ser Pro Trp 
        755                 760                 765             


Ala Phe Phe Arg Glu Asn Val Glu Ile Arg Ile Phe Ser Glu Asn Pro 
    770                 775                 780                 


Lys Leu Glu Leu Glu Asn Arg Leu Pro Asp Tyr Pro Gln Tyr Asn His 
785                 790                 795                 800 


Glu Phe Val Gln Pro Leu Phe Val Ser Arg Met Pro Thr Arg Lys Met 
                805                 810                 815     


Thr Gly Gln Gly His Met Glu Thr Val Lys Ser Ala Lys Arg Leu Asp 
            820                 825                 830         


Glu Gly Leu Ser Val Leu Lys Val Pro Leu Thr Gln Leu Lys Leu Asn 
        835                 840                 845             


Asp Leu Glu Arg Met Val Asn Arg Glu Arg Glu Met Ala Leu Tyr Glu 
    850                 855                 860                 


Ser Leu Lys Val Arg Leu Glu Gln Phe Asp Asn Asp Pro Ala Lys Ala 
865                 870                 875                 880 


Phe Ala Glu Pro Phe Tyr Lys Lys Gly Gly Ala Leu Val Lys Ala Val 
                885                 890                 895     


Arg Val Glu Gln Thr Gln Lys Ser Gly Val Leu Val Arg Asp Gly Asn 
            900                 905                 910         


Gly Val Ala Asp Asn Ala Ser Met Val Arg Val Asp Val Phe Thr Lys 
        915                 920                 925             


Ala Gly Lys Tyr Phe Leu Val Pro Ile Tyr Thr Trp Gln Val Ala Lys 
    930                 935                 940                 


Gly Ile Leu Pro Asn Lys Ala Val Thr Ala Asn Val Asp Glu Ile Asp 
945                 950                 955                 960 


Trp Leu Glu Met Asp Glu Ser Tyr Gln Phe Ile Phe Thr Met Tyr Pro 
                965                 970                 975     


Asn Asp Leu Val Lys Val Lys Leu Lys Lys Glu Glu Phe Phe Gly Tyr 
            980                 985                 990         


Tyr Gly Gly Leu Asp Arg Ala Thr  Gly Ala Ile Val Ile  Lys Glu His 
        995                 1000                 1005             


Asp Leu  Glu Lys Ser Lys Gly  Arg Gln Gly Ile Tyr  Arg Ile Gly 
    1010                 1015                 1020             


Val Lys  Leu Ala Leu Ser Phe  Glu Lys Tyr Gln Val  Asp Glu Leu 
    1025                 1030                 1035             


Gly Lys  Asn Ile Arg Pro Cys  Arg Pro Thr Lys Arg  Gln His Val 
    1040                 1045                 1050             


Arg 
    


<210> 47
<211> 1062
<212> PRT
<213> Actinobacillus succinogenes

<400> 47
Met Asn Leu Asn Tyr Ile Leu Gly Leu Asp Leu Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Glu Ile Asp Glu Gln Glu Asn Pro Gln Arg Leu 
            20                  25                  30          


Ile Asp Val Gly Val Arg Thr Phe Asp Arg Ala Glu Val Leu Lys Thr 
        35                  40                  45              


Gly Glu Ser Leu Ala Leu Ala Arg Arg Leu Ala Arg Ser Ser Arg Arg 
    50                  55                  60                  


Leu Val Lys Arg Arg Ala Glu Arg Ile Lys Lys Ala Lys Arg Leu Leu 
65                  70                  75                  80  


Lys Ala Glu Asn Leu Leu Leu Ser Ala Asp Glu Ile Leu Pro Asn Glu 
                85                  90                  95      


Ala Trp Gln Leu Arg Val Lys Gly Leu Asp Gln Lys Leu Glu Arg Gln 
            100                 105                 110         


Glu Trp Ala Ala Val Leu Leu His Leu Leu Lys His Arg Gly Tyr Leu 
        115                 120                 125             


Ser Gln Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu Leu Gly Ala 
    130                 135                 140                 


Leu Leu Ser Gly Val Ala Ile Asn His Gln Ile Leu Gln Ser Ala Glu 
145                 150                 155                 160 


Tyr Arg Thr Pro Ala Glu Ile Ala Val Asn Lys Phe Gln Ala Glu Glu 
                165                 170                 175     


Gly His Ile Arg Asn Gln Arg Gly Ala Tyr Thr His Thr Phe Ser Arg 
            180                 185                 190         


Leu Asp Leu Leu Ala Glu Met Glu Leu Leu Phe Gln Arg Gln Ala Thr 
        195                 200                 205             


Leu Gly Asn Pro His Thr Ser Thr Lys Leu Leu Glu Asn Leu Thr Ala 
    210                 215                 220                 


Leu Leu Met Trp Gln Lys Pro Ala Leu Ala Gly Glu Ala Ile Leu Lys 
225                 230                 235                 240 


Met Leu Gly Lys Cys Thr Phe Glu Pro Thr Glu Tyr Lys Ala Ala Lys 
                245                 250                 255     


Asn Ser Tyr Ser Ala Glu Arg Phe Val Trp Leu Thr Lys Leu Asn Asn 
            260                 265                 270         


Leu Arg Ile Leu Glu Gln Gly Ala Glu Arg Ala Leu Thr Asp Asn Glu 
        275                 280                 285             


Arg Phe Ala Leu Leu Asp Gln Pro Tyr Glu Lys Ala Lys Leu Thr Tyr 
    290                 295                 300                 


Ala Gln Val Arg Thr Leu Leu Gly Leu Ser Asp Glu Ala Ile Phe Lys 
305                 310                 315                 320 


Gly Leu Arg Tyr Gln Gly Glu Asp Lys Lys Ala Val Glu Thr Lys Thr 
                325                 330                 335     


Thr Leu Met Glu Val Lys Ala Tyr His Gln Ile Arg Lys Ala Leu Glu 
            340                 345                 350         


Gly Leu Asp Leu Lys Ala Glu Trp Asn Glu Leu Lys Asn Asn Pro Ala 
        355                 360                 365             


Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp Asp 
    370                 375                 380                 


Asp Ile His Arg Tyr Leu Asp Gly Lys Leu Ser Glu Ser Val Leu Asn 
385                 390                 395                 400 


Ala Leu Leu Glu Asn Leu Asn Phe Asp Lys Phe Ile Gln Leu Ser Leu 
                405                 410                 415     


Lys Ala Leu Gln Gln Ile Leu Pro Leu Met Leu Gln Gly Gln Arg Tyr 
            420                 425                 430         


Asp Glu Ala Val Ser Ala Ile Tyr Gly Asp His Tyr Gly Lys Lys Ser 
        435                 440                 445             


Asp Glu Ile Asp Arg Leu Leu Pro Asn Ile Pro Thr Asp Glu Ile Arg 
    450                 455                 460                 


Asn Pro Val Val Leu Arg Thr Leu Thr Gln Ala Arg Lys Val Ile Asn 
465                 470                 475                 480 


Ala Val Val Arg Leu Tyr Gly Ser Pro Ala Arg Ile His Ile Glu Thr 
                485                 490                 495     


Gly Arg Glu Val Gly Lys Ser Tyr Gln Asp Arg Lys Lys Leu Glu Lys 
            500                 505                 510         


Gln Gln Glu Glu Asn Arg Lys Gln Arg Glu Asn Ala Val Lys Lys Phe 
        515                 520                 525             


Lys Glu Tyr Phe Pro Asn Phe Val Gly Glu Pro Lys Gly Lys Asp Ile 
    530                 535                 540                 


Leu Lys Met Arg Leu Tyr Glu Leu Gln Gln Ala Lys Cys Leu Tyr Ser 
545                 550                 555                 560 


Gly Lys Ser Leu Glu Leu Tyr Arg Leu Leu Glu Lys Gly Tyr Val Glu 
                565                 570                 575     


Val Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe Asn 
            580                 585                 590         


Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gln Asn Lys Gly Asn Ala 
        595                 600                 605             


Thr Pro Tyr Glu Trp Leu Asp Gly Lys Asn Asn Ser Glu Gly Trp Gln 
    610                 615                 620                 


His Phe Val Ala Arg Val Gln Thr Ser Gly Phe Ser Tyr Ala Lys Lys 
625                 630                 635                 640 


Gln Arg Val Leu Ile Gln Glu Leu Asp Glu Lys Ser Phe Ile Glu Arg 
                645                 650                 655     


Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys Asn His Ile 
            660                 665                 670         


Ala Asp Asn Met Leu Leu Thr Gly Lys Gly Lys Arg Lys Val Phe Ala 
        675                 680                 685             


Ser Asn Gly Gln Ile Thr Ala Leu Leu Arg Gly Cys Trp Gly Leu Gln 
    690                 695                 700                 


Lys Val Arg Glu Asn Asn Asp Arg His His Ala Leu Asp Ala Val Val 
705                 710                 715                 720 


Val Ala Cys Ser Thr Lys Ser Met Gln Asp Lys Ile Thr Lys Phe Val 
                725                 730                 735     


Lys Tyr Lys Glu Gly Arg Leu Phe Lys Asp Lys Lys Asp Gly Val Tyr 
            740                 745                 750         


Lys Gly Glu Arg Ile Asn Arg Glu Thr Gly Glu Ile Ile Ser Leu His 
        755                 760                 765             


Phe Pro Thr Pro Trp Lys Phe Phe Lys Glu Asn Val Glu Ile Arg Ile 
    770                 775                 780                 


Phe Ser Glu Asn Pro Lys Leu Glu Leu Glu Asn Arg Leu Pro Asp Tyr 
785                 790                 795                 800 


Pro Gln Tyr Asn His Glu Phe Val Gln Pro Leu Phe Val Ser Arg Met 
                805                 810                 815     


Pro Thr Arg Lys Met Thr Gly Gln Gly His Met Glu Thr Val Lys Ser 
            820                 825                 830         


Ala Lys Arg Leu Asp Lys Gly Leu Ser Val Leu Lys Val Pro Leu Thr 
        835                 840                 845             


Gln Leu Lys Leu Ser Asp Leu Glu Arg Met Val Asn Arg Glu Arg Glu 
    850                 855                 860                 


Met Ala Leu Tyr Glu Ala Leu Lys Glu Cys Leu Glu Gln Phe Gly Asn 
865                 870                 875                 880 


Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Lys Gly Gly Ala 
                885                 890                 895     


Leu Val Lys Ala Val Arg Val Glu Gln Thr Gln Lys Ser Gly Val Leu 
            900                 905                 910         


Val Arg Asn Gly Asn Gly Val Ala Asp Asn Ala Thr Gly Ser Ile Val 
        915                 920                 925             


Arg Val Asp Val Phe Thr Lys Gly Gly Lys Tyr Phe Leu Val Pro Ile 
    930                 935                 940                 


Tyr Thr Trp Gln Val Ala Lys Gly Ile Leu Pro Asn Lys Ala Val Ile 
945                 950                 955                 960 


Gln Gly Lys Asp Glu Ser Glu Trp Glu Glu Met Asp Glu Asn Ala Val 
                965                 970                 975     


Phe Gln Phe Ser Met His Lys Asn Asp Leu Ile Lys Val Lys Thr Lys 
            980                 985                 990         


Lys Gly Glu Ile Phe Gly Tyr Phe  Asn Gly Leu Asp Arg  Ala Thr Gly 
        995                 1000                 1005             


Ser Ile  Glu Ile Glu Glu His  Asp Leu Glu Lys Ser  Lys Gly Lys 
    1010                 1015                 1020             


Asn Gly  Ser His Arg Gly Leu  Gly Val Lys Thr Ala  Phe Phe Leu 
    1025                 1030                 1035             


Glu Lys  Tyr Gln Val Asp Glu  Leu Gly Lys Asn Ile  Arg Pro Cys 
    1040                 1045                 1050             


Arg Pro  Thr Lys Arg Gln His  Val Arg 
    1055                 1060         


<210> 48
<211> 1054
<212> PRT
<213> Actinobacillus suis

<400> 48
Met Lys Leu Thr Pro Leu Asn Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Val Val Glu Ile Asp Glu Gln Glu Asn Pro 
            20                  25                  30          


Leu Gly Leu Ile Asp Val Gly Val Arg Thr Phe Asp Arg Ala Glu Val 
        35                  40                  45              


Pro Lys Thr Gly Glu Ser Leu Ala Leu Ala Arg Arg Leu Ala Arg Ser 
    50                  55                  60                  


Ala Arg Arg Leu Val Lys Arg Arg Ala Asp Arg Ile Lys Lys Ala Lys 
65                  70                  75                  80  


Arg Leu Leu Lys Ala Glu Asn Ile Leu Leu Ser Ala Asp Glu His Leu 
                85                  90                  95      


Pro Asn Asp Val Trp Gln Leu Arg Val Lys Gly Leu Asp Gln Lys Leu 
            100                 105                 110         


Glu Arg Gln Glu Trp Ala Ala Val Leu Leu His Leu Leu Lys His Arg 
        115                 120                 125             


Gly Tyr Leu Ser Gln Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu 
    130                 135                 140                 


Leu Gly Ala Leu Leu Ser Gly Val Glu Thr Asn His Gln Ile Leu Gln 
145                 150                 155                 160 


Ser Ala Glu Tyr Arg Thr Pro Ala Glu Ile Ala Val Lys Lys Phe His 
                165                 170                 175     


Val Glu Asp Gly His Ile Arg Asn Gln Arg Gly Ala Tyr Thr His Thr 
            180                 185                 190         


Phe Ser Arg Leu Asp Leu Leu Ala Glu Met Glu Leu Leu Phe Gln Arg 
        195                 200                 205             


Gln Thr Asp Leu Gly Asn Pro His Thr Ser Ala Lys Leu Leu Glu Asn 
    210                 215                 220                 


Leu Thr Ala Leu Leu Met Trp Gln Lys Pro Ala Leu Ala Gly Glu Ala 
225                 230                 235                 240 


Ile Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Pro Thr Glu Tyr Lys 
                245                 250                 255     


Ala Ala Lys Asn Ser Tyr Ser Ala Glu Arg Phe Val Trp Leu Thr Lys 
            260                 265                 270         


Leu Asn Asn Leu Arg Ile Leu Glu Gln Gly Ala Glu Arg Ala Leu Thr 
        275                 280                 285             


Asp Asn Glu Arg Phe Ala Leu Leu Asp Gln Pro Tyr Glu Lys Ala Lys 
    290                 295                 300                 


Phe Thr Tyr Ala Gln Ala Arg Thr Met Leu Ala Leu Pro Asp Glu Ala 
305                 310                 315                 320 


Ile Phe Lys Gly Val Arg Tyr Gln Gly Glu Asp Lys Lys Ala Val Glu 
                325                 330                 335     


Thr Lys Thr Ile Leu Met Glu Met Lys Ala Tyr His Gln Ile Arg Lys 
            340                 345                 350         


Ala Leu Glu Asn Ala Asp Leu Lys Ala Glu Trp Asn Glu Leu Lys Asn 
        355                 360                 365             


Asn Ser Glu Leu Leu Asp Asp Ile Gly Thr Ala Phe Ser Leu His Lys 
    370                 375                 380                 


Thr Asp Glu Asp Ile Cys Arg Tyr Leu Asp Gly Lys Leu Ser Glu Ser 
385                 390                 395                 400 


Ile Leu Asn Ala Leu Leu Glu Asn Leu Asn Phe Asp Lys Phe Ile Gln 
                405                 410                 415     


Leu Ser Leu Lys Ala Leu Gln Gln Ile Leu Pro Leu Met Leu Gln Gly 
            420                 425                 430         


Gln Arg Tyr Asp Glu Ala Val Ser Ala Ile Tyr Gly Asp His Tyr Gly 
        435                 440                 445             


Lys Lys Ser Ala Glu Ile Asn Arg Leu Leu Pro Thr Ile Pro Ala Asp 
    450                 455                 460                 


Glu Ile Arg Asn Pro Val Val Leu Arg Thr Leu Thr Gln Ala Arg Lys 
465                 470                 475                 480 


Val Ile Asn Ala Val Val Arg Leu Tyr Gly Ser Pro Ala Arg Ile His 
                485                 490                 495     


Ile Glu Thr Gly Arg Glu Val Gly Lys Ser Tyr Gln Asp Arg Lys Lys 
            500                 505                 510         


Leu Glu Lys Gln Gln Glu Asp Asn Arg Lys Gln Arg Glu Ser Ala Val 
        515                 520                 525             


Lys Lys Phe Lys Glu Tyr Phe Pro Asn Phe Val Gly Glu Pro Lys Gly 
    530                 535                 540                 


Lys Asp Ile Leu Lys Met Arg Leu Tyr Glu Leu Gln Gln Ala Lys Cys 
545                 550                 555                 560 


Leu Tyr Ser Gly Lys Ser Leu Glu Leu His Arg Leu Leu Glu Lys Gly 
                565                 570                 575     


Tyr Val Glu Val Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp 
            580                 585                 590         


Ser Phe Asn Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gln Asn Lys 
        595                 600                 605             


Gly Asn Leu Thr Pro Tyr Glu Trp Leu Asp Gly Lys Asn Asn Ser Glu 
    610                 615                 620                 


His Trp Gln Asn Phe Val Ala Arg Val Gln Thr Ser Gly Phe Ser His 
625                 630                 635                 640 


Thr Lys Lys Gln Arg Ile Leu Ser His Lys Leu Asp Glu Lys Gly Phe 
                645                 650                 655     


Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys 
            660                 665                 670         


Asn Phe Ile Ala Asp Asn Met Leu Leu Thr Gly Lys Gly Lys Arg Lys 
        675                 680                 685             


Val Phe Ala Ser Asn Gly Gln Ile Thr Ala Leu Leu Arg Gly Arg Trp 
    690                 695                 700                 


Gly Leu Gln Lys Val Arg Asp Asp Asn Asp Arg His His Ala Leu Asp 
705                 710                 715                 720 


Ala Val Val Val Ala Cys Ser Thr Val Val Met Gln Gln Lys Ile Thr 
                725                 730                 735     


Arg Phe Val Arg Tyr Glu Glu Gly Asn Val Phe Ser Gly Glu Arg Ile 
            740                 745                 750         


Asp Arg Glu Thr Gly Glu Ile Ile Pro Leu His Phe Pro Ser Pro Trp 
        755                 760                 765             


Ala Phe Phe Arg Glu Asn Val Glu Ile Arg Ile Phe Ser Glu Asn Pro 
    770                 775                 780                 


Lys Leu Glu Leu Glu Asn Arg Leu Pro Asp Tyr Pro Gln Tyr Asn His 
785                 790                 795                 800 


Glu Phe Val Gln Pro Leu Phe Val Ser Arg Met Pro Thr Arg Lys Met 
                805                 810                 815     


Thr Gly Gln Gly His Met Glu Thr Val Lys Ser Ala Lys Arg Leu Asp 
            820                 825                 830         


Glu Gly Leu Ser Val Leu Lys Val Pro Leu Thr Gln Leu Lys Leu Ser 
        835                 840                 845             


Asp Leu Glu Arg Met Val Asn Arg Glu Arg Glu Val Thr Leu Tyr Glu 
    850                 855                 860                 


Ser Leu Lys Ala Arg Leu Glu Gln Phe Gly Asn Asp Pro Ala Lys Ala 
865                 870                 875                 880 


Phe Ala Glu Pro Phe His Lys Lys Gly Gly Ala Val Val Lys Ala Val 
                885                 890                 895     


Arg Val Glu Gln Thr Gln Lys Ser Gly Val Leu Val Arg Asp Gly Asn 
            900                 905                 910         


Gly Val Ala Asp Asn Ala Ser Met Val Arg Val Asp Val Phe Thr Lys 
        915                 920                 925             


Gly Gly Lys Tyr Phe Leu Val Pro Ile Tyr Thr Trp Gln Val Ala Lys 
    930                 935                 940                 


Gly Ile Leu Pro Asn Lys Ala Val Thr Ala Asn Val Asp Glu Ile Asp 
945                 950                 955                 960 


Trp Leu Glu Met Asp Glu Ser Tyr Gln Phe Ile Phe Thr Met Tyr Pro 
                965                 970                 975     


Asn Asp Leu Val Lys Val Lys Leu Lys Lys Glu Glu Phe Phe Gly Tyr 
            980                 985                 990         


Tyr Gly Gly Leu Asp Arg Ala Thr  Gly Ala Ile Val Ile  Lys Glu His 
        995                 1000                 1005             


Asp Leu  Glu Lys Ser Lys Gly  Lys Gln Gly Ile Tyr  Arg Ile Gly 
    1010                 1015                 1020             


Val Lys  Leu Ala Leu Ser Phe  Glu Lys Tyr Gln Val  Asp Glu Leu 
    1025                 1030                 1035             


Gly Lys  Asn Ile Arg Pro Cys  Arg Pro Thr Lys Arg  Gln His Val 
    1040                 1045                 1050             


Arg 
    


<210> 49
<211> 1105
<212> PRT
<213> Actinomyces coleocanis


<220>
<223> Actinomyces coleocanis DSM 15436

<400> 49
Met Asp Asn Lys Asn Tyr Arg Ile Gly Ile Asp Val Gly Leu Asn Ser 
1               5                   10                  15      


Ile Gly Phe Cys Ala Val Glu Val Asp Gln His Asp Thr Pro Leu Gly 
            20                  25                  30          


Phe Leu Asn Leu Ser Val Tyr Arg His Asp Ala Gly Ile Asp Pro Asn 
        35                  40                  45              


Gly Lys Lys Thr Asn Thr Thr Arg Leu Ala Met Ser Gly Val Ala Arg 
    50                  55                  60                  


Arg Thr Arg Arg Leu Phe Arg Lys Arg Lys Arg Arg Leu Ala Ala Leu 
65                  70                  75                  80  


Asp Arg Phe Ile Glu Ala Gln Gly Trp Thr Leu Pro Asp His Ala Asp 
                85                  90                  95      


Tyr Lys Asp Pro Tyr Thr Pro Trp Leu Val Arg Ala Glu Leu Ala Gln 
            100                 105                 110         


Thr Pro Ile Arg Asp Glu Asn Asp Leu His Glu Lys Leu Ala Ile Ala 
        115                 120                 125             


Val Arg His Ile Ala Arg His Arg Gly Trp Arg Ser Pro Trp Val Pro 
    130                 135                 140                 


Val Arg Ser Leu His Val Glu Gln Pro Pro Ser Asp Gln Tyr Leu Ala 
145                 150                 155                 160 


Leu Lys Glu Arg Val Glu Ala Lys Thr Leu Leu Gln Met Pro Glu Gly 
                165                 170                 175     


Ala Thr Pro Ala Glu Met Val Val Ala Leu Asp Leu Ser Val Asp Val 
            180                 185                 190         


Asn Leu Arg Pro Lys Asn Arg Glu Lys Thr Asp Thr Arg Pro Glu Asn 
        195                 200                 205             


Lys Lys Pro Gly Phe Leu Gly Gly Lys Leu Met Gln Ser Asp Asn Ala 
    210                 215                 220                 


Asn Glu Leu Arg Lys Ile Ala Lys Ile Gln Gly Leu Asp Asp Ala Leu 
225                 230                 235                 240 


Leu Arg Glu Leu Ile Glu Leu Val Phe Ala Ala Asp Ser Pro Lys Gly 
                245                 250                 255     


Ala Ser Gly Glu Leu Val Gly Tyr Asp Val Leu Pro Gly Gln His Gly 
            260                 265                 270         


Lys Arg Arg Ala Glu Lys Ala His Pro Ala Phe Gln Arg Tyr Arg Ile 
        275                 280                 285             


Ala Ser Ile Val Ser Asn Leu Arg Ile Arg His Leu Gly Ser Gly Ala 
    290                 295                 300                 


Asp Glu Arg Leu Asp Val Glu Thr Gln Lys Arg Val Phe Glu Tyr Leu 
305                 310                 315                 320 


Leu Asn Ala Lys Pro Thr Ala Asp Ile Thr Trp Ser Asp Val Ala Glu 
                325                 330                 335     


Glu Ile Gly Val Glu Arg Asn Leu Leu Met Gly Thr Ala Thr Gln Thr 
            340                 345                 350         


Ala Asp Gly Glu Arg Ala Ser Ala Lys Pro Pro Val Asp Val Thr Asn 
        355                 360                 365             


Val Ala Phe Ala Thr Cys Lys Ile Lys Pro Leu Lys Glu Trp Trp Leu 
    370                 375                 380                 


Asn Ala Asp Tyr Glu Ala Arg Cys Val Met Val Ser Ala Leu Ser His 
385                 390                 395                 400 


Ala Glu Lys Leu Thr Glu Gly Thr Ala Ala Glu Val Glu Val Ala Glu 
                405                 410                 415     


Phe Leu Gln Asn Leu Ser Asp Glu Asp Asn Glu Lys Leu Asp Ser Phe 
            420                 425                 430         


Ser Leu Pro Ile Gly Arg Ala Ala Tyr Ser Val Asp Ser Leu Glu Arg 
        435                 440                 445             


Leu Thr Lys Arg Met Ile Glu Asn Gly Glu Asp Leu Phe Glu Ala Arg 
    450                 455                 460                 


Val Asn Glu Phe Gly Val Ser Glu Asp Trp Arg Pro Pro Ala Glu Pro 
465                 470                 475                 480 


Ile Gly Ala Arg Val Gly Asn Pro Ala Val Asp Arg Val Leu Lys Ala 
                485                 490                 495     


Val Asn Arg Tyr Leu Met Ala Ala Glu Ala Glu Trp Gly Ala Pro Leu 
            500                 505                 510         


Ser Val Asn Ile Glu His Val Arg Glu Gly Phe Ile Ser Lys Arg Gln 
        515                 520                 525             


Ala Val Glu Ile Asp Arg Glu Asn Gln Lys Arg Tyr Gln Arg Asn Gln 
    530                 535                 540                 


Ala Val Arg Ser Gln Ile Ala Asp His Ile Asn Ala Thr Ser Gly Val 
545                 550                 555                 560 


Arg Gly Ser Asp Val Thr Arg Tyr Leu Ala Ile Gln Arg Gln Asn Gly 
                565                 570                 575     


Glu Cys Leu Tyr Cys Gly Thr Ala Ile Thr Phe Val Asn Ser Glu Met 
            580                 585                 590         


Asp His Ile Val Pro Arg Ala Gly Leu Gly Ser Thr Asn Thr Arg Asp 
        595                 600                 605             


Asn Leu Val Ala Thr Cys Glu Arg Cys Asn Lys Ser Lys Ser Asn Lys 
    610                 615                 620                 


Pro Phe Ala Val Trp Ala Ala Glu Cys Gly Ile Pro Gly Val Ser Val 
625                 630                 635                 640 


Ala Glu Ala Leu Lys Arg Val Asp Phe Trp Ile Ala Asp Gly Phe Ala 
                645                 650                 655     


Ser Ser Lys Glu His Arg Glu Leu Gln Lys Gly Val Lys Asp Arg Leu 
            660                 665                 670         


Lys Arg Lys Val Ser Asp Pro Glu Ile Asp Asn Arg Ser Met Glu Ser 
        675                 680                 685             


Val Ala Trp Met Ala Arg Glu Leu Ala His Arg Val Gln Tyr Tyr Phe 
    690                 695                 700                 


Asp Glu Lys His Thr Gly Thr Lys Val Arg Val Phe Arg Gly Ser Leu 
705                 710                 715                 720 


Thr Ser Ala Ala Arg Lys Ala Ser Gly Phe Glu Ser Arg Val Asn Phe 
                725                 730                 735     


Ile Gly Gly Asn Gly Lys Thr Arg Leu Asp Arg Arg His His Ala Met 
            740                 745                 750         


Asp Ala Ala Thr Val Ala Met Leu Arg Asn Ser Val Ala Lys Thr Leu 
        755                 760                 765             


Val Leu Arg Gly Asn Ile Arg Ala Ser Glu Arg Ala Ile Gly Ala Ala 
    770                 775                 780                 


Glu Thr Trp Lys Ser Phe Arg Gly Glu Asn Val Ala Asp Arg Gln Ile 
785                 790                 795                 800 


Phe Glu Ser Trp Ser Glu Asn Met Arg Val Leu Val Glu Lys Phe Asn 
                805                 810                 815     


Leu Ala Leu Tyr Asn Asp Glu Val Ser Ile Phe Ser Ser Leu Arg Leu 
            820                 825                 830         


Gln Leu Gly Asn Gly Lys Ala His Asp Asp Thr Ile Thr Lys Leu Gln 
        835                 840                 845             


Met His Lys Val Gly Asp Ala Trp Ser Leu Thr Glu Ile Asp Arg Ala 
    850                 855                 860                 


Ser Thr Pro Ala Leu Trp Cys Ala Leu Thr Arg Gln Pro Asp Phe Thr 
865                 870                 875                 880 


Trp Lys Asp Gly Leu Pro Ala Asn Glu Asp Arg Thr Ile Ile Val Asn 
                885                 890                 895     


Gly Thr His Tyr Gly Pro Leu Asp Lys Val Gly Ile Phe Gly Lys Ala 
            900                 905                 910         


Ala Ala Ser Leu Leu Val Arg Gly Gly Ser Val Asp Ile Gly Ser Ala 
        915                 920                 925             


Ile His His Ala Arg Ile Tyr Arg Ile Ala Gly Lys Lys Pro Thr Tyr 
    930                 935                 940                 


Gly Met Val Arg Val Phe Ala Pro Asp Leu Leu Arg Tyr Arg Asn Glu 
945                 950                 955                 960 


Asp Leu Phe Asn Val Glu Leu Pro Pro Gln Ser Val Ser Met Arg Tyr 
                965                 970                 975     


Ala Glu Pro Lys Val Arg Glu Ala Ile Arg Glu Gly Lys Ala Glu Tyr 
            980                 985                 990         


Leu Gly Trp Leu Val Val Gly Asp  Glu Leu Leu Leu Asp  Leu Ser Ser 
        995                 1000                 1005             


Glu Thr  Ser Gly Gln Ile Ala  Glu Leu Gln Gln Asp  Phe Pro Gly 
    1010                 1015                 1020             


Thr Thr  His Trp Thr Val Ala  Gly Phe Phe Ser Pro  Ser Arg Leu 
    1025                 1030                 1035             


Arg Leu  Arg Pro Val Tyr Leu  Ala Gln Glu Gly Leu  Gly Glu Asp 
    1040                 1045                 1050             


Val Ser  Glu Gly Ser Lys Ser  Ile Ile Ala Gly Gln  Gly Trp Arg 
    1055                 1060                 1065             


Pro Ala  Val Asn Lys Val Phe  Gly Ser Ala Met Pro  Glu Val Ile 
    1070                 1075                 1080             


Arg Arg  Asp Gly Leu Gly Arg  Lys Arg Arg Phe Ser  Tyr Ser Gly 
    1085                 1090                 1095             


Leu Pro  Val Ser Trp Gln Gly  
    1100                 1105 


<210> 50
<211> 1113
<212> PRT
<213> Actinomyces georgiae


<220>
<223> Actinomyces georgiae F0490

<400> 50
Met Ser Ala Ser Ser Gln Asn Val Glu Arg Ile Arg Tyr Lys Val Gly 
1               5                   10                  15      


Ile Asp Val Gly Leu Arg Ser Ile Gly Phe Cys Ala Val Gln Val Asp 
            20                  25                  30          


Ala Asp Asp Arg Pro Val Lys Leu Leu Asn Thr Val Val His Val His 
        35                  40                  45              


Asp Ala Gly Val Ser Pro Ala Asp Ala Lys Lys Ala Asp Thr Arg Lys 
    50                  55                  60                  


Leu Val Ser Gly Val Ala Arg Arg Thr Arg Arg Leu Tyr Arg Thr Arg 
65                  70                  75                  80  


Lys Arg Arg Leu Val Asp Leu Asp Arg Gln Leu Asp Gly Leu Gly Trp 
                85                  90                  95      


Pro Leu Val Asp Pro Ala Arg Phe Ala Asp Pro Arg Glu Pro Trp Phe 
            100                 105                 110         


Ala Arg Glu Lys Leu Val Ser Gly Arg Val Asp Asp Ala Asp Glu Arg 
        115                 120                 125             


Lys Glu Leu Leu Ser Val Ala Leu Arg His Ile Ala His His Arg Gly 
    130                 135                 140                 


Trp Arg Asn Pro Tyr Ser Thr Val Glu Ser Leu Gln Ala Asp Ala Pro 
145                 150                 155                 160 


Pro Ser Glu Phe Leu Gln Gly Leu Asn Gln Arg Val Ser Glu Lys Leu 
                165                 170                 175     


Gly Thr Glu Leu Asp Pro Gly Leu Thr Gln Gly Gln Leu Val Ala Lys 
            180                 185                 190         


Leu Leu His Arg Phe Pro Asn Ala Lys Ile Arg Gly Pro Glu Gly Ile 
        195                 200                 205             


Leu Arg Gly Lys Leu His Gln Ser Asp Asn Ala Gly Glu Leu Arg Leu 
    210                 215                 220                 


Ile Cys Arg Thr Gln Gly Leu Asp Cys His Ile Thr Glu Glu Leu Val 
225                 230                 235                 240 


Arg Leu Val Phe Gln Ala Lys Ser Pro Lys Ala Asn Lys Glu Met Arg 
                245                 250                 255     


Lys Arg Ile Gly Arg Asp Gln Leu Pro Gly Gln Gly Ala His Ile Arg 
            260                 265                 270         


Ala Glu Lys Ala His Pro Val Phe Gln Arg Phe Arg Ile Val Ala Val 
        275                 280                 285             


Leu Ala Asn Leu Arg Ile Arg Glu Ala His Val Asp Arg Arg Leu Thr 
    290                 295                 300                 


Ala Glu Glu Met Arg Thr Leu Thr Asp Phe Leu Leu Gly Leu Ala Gly 
305                 310                 315                 320 


Ser Glu Gln Pro Thr Trp Glu Glu Leu Ala Asp Asn Leu Asn Ile Glu 
                325                 330                 335     


Arg His Gln Leu Arg Gly Thr Ala Lys Ala Ser Val Asp Gly Ala Pro 
            340                 345                 350         


Ala Leu Arg Phe Pro Pro Ile Asp Ala Thr Thr Asp Arg Ile Tyr Ala 
        355                 360                 365             


Ser Lys Leu Lys Trp Leu Ala Glu Trp Trp Arg Gln Ala Asp Glu Glu 
    370                 375                 380                 


Arg Arg Gly Tyr Met Val Asp Ala Leu Ser Asn Ser Gly Gly Ser Glu 
385                 390                 395                 400 


Asp Glu Pro Tyr Leu Asp Asp Glu Ile Ala Glu Met Leu Glu Gln Ala 
                405                 410                 415     


Ser Glu Glu Asp Gln Ala Lys Leu Asp Ser Leu His Leu Pro Gly Gly 
            420                 425                 430         


Arg Ala Ser Tyr Cys Leu Asp Thr Leu Arg Arg Leu Thr Asp Ala Met 
        435                 440                 445             


Leu Gly Gly Gly Leu Asp Leu Phe Glu Ala Arg Lys Ala Val Phe His 
    450                 455                 460                 


Val Asp Asp Asp Trp Ala Pro Pro Thr Asp Pro Ile Gly Ala Pro Val 
465                 470                 475                 480 


Gly Asn Pro Pro Val Asp Arg Val Leu Lys His Val Ala Arg Trp Leu 
                485                 490                 495     


Glu Ala Ala Thr Gly Arg Trp Gly Ala Pro Gln Thr Ile Asn Ile Glu 
            500                 505                 510         


His Val Arg Glu Gly Leu Gly Ser Glu Lys Ala Ala Arg Glu Leu Thr 
        515                 520                 525             


Arg Met Asn Asp Arg Arg Arg Arg Asn Asn Gln Lys Leu Val Glu Glu 
    530                 535                 540                 


Met Gly Glu Lys Leu Gly Met Ser Gly Arg Ile Arg Arg Ser Asp Arg 
545                 550                 555                 560 


Met Arg Tyr Glu Ala Ile Arg Arg Gln Asn Cys Glu Cys Leu Tyr Cys 
                565                 570                 575     


Gly Gln Pro Ile Thr Tyr Gln Thr Met Glu Met Asp His Ile Val Pro 
            580                 585                 590         


Arg Ala Gly Ala Ala Ser Thr Asn Ser Arg Ser Asn Leu Ala Ala Val 
        595                 600                 605             


Cys Arg Arg Cys Asn His Gln Lys Gly Lys Leu Pro Phe Ala Val Trp 
    610                 615                 620                 


Ala Glu Ser Gln Asp Ser Pro Ala Glu Val Arg Leu Gln Asp Ala Val 
625                 630                 635                 640 


Gln Arg Val Arg His Trp Leu Arg Asp Ala Gly Met Gly Gln Lys Glu 
                645                 650                 655     


Leu Gln Ala Leu Arg Val Gln Val Ile Ala Arg Leu Lys Ser Lys Arg 
            660                 665                 670         


Pro Asp Glu Glu Phe Asp Gly Arg Ser Met Glu Ser Ile Ala Trp Met 
        675                 680                 685             


Ala Asn Glu Leu Arg Ala Arg Val Glu Ala Gln Tyr Arg Gly Ser Gly 
    690                 695                 700                 


Thr Thr Val Arg Val Tyr Arg Gly Ala Leu Thr Ala Glu Ala Arg Lys 
705                 710                 715                 720 


Ala Ser Gly Phe Glu Gly Arg Val Asn Leu Ile Gly Gly Arg Gly Lys 
                725                 730                 735     


Asp Arg Phe Asp Arg Arg His His Ala Met Asp Ala Leu Val Ile Ala 
            740                 745                 750         


Leu Met Asn Gln Ser Val Ala Gln Thr Leu Ala Leu Arg Leu Asn Met 
        755                 760                 765             


Arg Asp Ser Gln Trp Leu Thr Gln Ser Glu Gln Thr Trp Arg Gln Phe 
    770                 775                 780                 


His Gly Ala Pro Gly Glu Ala Ala Arg Lys Trp Glu Ala Trp Asp Arg 
785                 790                 795                 800 


Asp Met Arg Asp Ala Ser Asp Leu Phe Asn Leu Ala Leu Asp Gly Gly 
                805                 810                 815     


Arg Ile Pro Ile Thr Glu Asn Val Arg Leu Arg Val Gly Asn Gly Arg 
            820                 825                 830         


Val His Glu Asp Gly Val Ile Arg Phe Lys Pro Glu Tyr Glu Val Lys 
        835                 840                 845             


Gly Lys Thr Ile Lys Gly Gly Glu Ala Arg Leu Leu Gly Asp Ser Leu 
    850                 855                 860                 


Pro Ser Glu Gln Ile Asp Arg Ala Glu Thr Pro Ala Leu Trp Thr Ala 
865                 870                 875                 880 


Leu Thr Arg Leu Pro Glu Tyr Asp Arg Lys Ser Gly Leu Pro Glu Asn 
                885                 890                 895     


Pro Asp Arg Val Ile Arg Val Asn Gly Ala Val Val Gln Ala Thr Asp 
            900                 905                 910         


Arg Ile Arg Phe Phe Gly Thr Pro Ala Ser Val Ala Val Arg Gly Gly 
        915                 920                 925             


Tyr Ala Lys Leu Gly Glu Ser Ile His His Ala Arg Ile Tyr Arg Ile 
    930                 935                 940                 


Asn Gly Lys Thr Pro Lys Tyr Ala Met Ile Arg Val Tyr Thr Ile Asp 
945                 950                 955                 960 


Leu Met Arg Leu Asn His Glu Asp Ile Phe Thr Ala Val Leu Lys Pro 
                965                 970                 975     


Ser Thr Ile Ser Met Arg Cys Ala Glu Lys Lys Leu Lys Tyr Ala Ile 
            980                 985                 990         


Ala Glu Gly Asn Ala Glu Gln Ile  Gly Trp Leu Val Glu  Gly Asp Gln 
        995                 1000                 1005             


Leu Glu  Leu Asp Ala Ala Ala  Tyr Ala Lys Gly Val  Gly Ala Asp 
    1010                 1015                 1020             


Leu Met  Arg Glu Tyr Pro Met  Ala Thr Cys Trp Arg  Val Ala Gly 
    1025                 1030                 1035             


Phe Pro  Asp Glu Ala Lys Leu  Arg Leu Arg Pro Val  Leu Leu Ala 
    1040                 1045                 1050             


Ala Glu  Gly Met Gly Glu Asp  Ala Pro Lys Phe Met  Arg Glu Val 
    1055                 1060                 1065             


Leu Glu  Asn Gln Gly Trp Arg  Pro Ala Val Asn Ala  Leu Leu Ser 
    1070                 1075                 1080             


Pro Gly  Ser Val Arg Val Val  Arg Arg Asn Val Leu  Gly Glu Pro 
    1085                 1090                 1095             


Arg Phe  Lys Ser Ser Gly His  Leu Pro Thr Thr Val  Asp Leu Val 
    1100                 1105                 1110             


<210> 51
<211> 1101
<212> PRT
<213> Actinomyces naeslundii


<220>
<223> Actinomyces naeslundii str. Howell 279

<400> 51
Met Trp Tyr Ala Ser Leu Met Ser Ala His His Leu Arg Val Gly Ile 
1               5                   10                  15      


Asp Val Gly Thr His Ser Val Gly Leu Ala Thr Leu Arg Val Asp Asp 
            20                  25                  30          


His Gly Thr Pro Ile Glu Leu Leu Ser Ala Leu Ser His Ile His Asp 
        35                  40                  45              


Ser Gly Val Gly Lys Glu Gly Lys Lys Asp His Asp Thr Arg Lys Lys 
    50                  55                  60                  


Leu Ser Gly Ile Ala Arg Arg Ala Arg Arg Leu Leu His His Arg Arg 
65                  70                  75                  80  


Thr Gln Leu Gln Gln Leu Asp Glu Val Leu Arg Asp Leu Gly Phe Pro 
                85                  90                  95      


Ile Pro Thr Pro Gly Glu Phe Leu Asp Leu Asn Glu Gln Thr Asp Pro 
            100                 105                 110         


Tyr Arg Val Trp Arg Val Arg Ala Arg Leu Val Glu Glu Lys Leu Pro 
        115                 120                 125             


Glu Glu Leu Arg Gly Pro Ala Ile Ser Met Ala Val Arg His Ile Ala 
    130                 135                 140                 


Arg His Arg Gly Trp Arg Asn Pro Tyr Ser Lys Val Glu Ser Leu Leu 
145                 150                 155                 160 


Ser Pro Ala Glu Glu Ser Pro Phe Met Lys Ala Leu Arg Glu Arg Ile 
                165                 170                 175     


Leu Ala Thr Thr Gly Glu Val Leu Asp Asp Gly Ile Thr Pro Gly Gln 
            180                 185                 190         


Ala Met Ala Gln Val Ala Leu Thr His Asn Ile Ser Met Arg Gly Pro 
        195                 200                 205             


Glu Gly Ile Leu Gly Lys Leu His Gln Ser Asp Asn Ala Asn Glu Ile 
    210                 215                 220                 


Arg Lys Ile Cys Ala Arg Gln Gly Val Ser Pro Asp Val Cys Lys Gln 
225                 230                 235                 240 


Leu Leu Arg Ala Val Phe Lys Ala Asp Ser Pro Arg Gly Ser Ala Val 
                245                 250                 255     


Ser Arg Val Ala Pro Asp Pro Leu Pro Gly Gln Gly Ser Phe Arg Arg 
            260                 265                 270         


Ala Pro Lys Cys Asp Pro Glu Phe Gln Arg Phe Arg Ile Ile Ser Ile 
        275                 280                 285             


Val Ala Asn Leu Arg Ile Ser Glu Thr Lys Gly Glu Asn Arg Pro Leu 
    290                 295                 300                 


Thr Ala Asp Glu Arg Arg His Val Val Thr Phe Leu Thr Glu Asp Ser 
305                 310                 315                 320 


Gln Ala Asp Leu Thr Trp Val Asp Val Ala Glu Lys Leu Gly Val His 
                325                 330                 335     


Arg Arg Asp Leu Arg Gly Thr Ala Val His Thr Asp Asp Gly Glu Arg 
            340                 345                 350         


Ser Ala Ala Arg Pro Pro Ile Asp Ala Thr Asp Arg Ile Met Arg Gln 
        355                 360                 365             


Thr Lys Ile Ser Ser Leu Lys Thr Trp Trp Glu Glu Ala Asp Ser Glu 
    370                 375                 380                 


Gln Arg Gly Ala Met Ile Arg Tyr Leu Tyr Glu Asp Pro Thr Asp Ser 
385                 390                 395                 400 


Glu Cys Ala Glu Ile Ile Ala Glu Leu Pro Glu Glu Asp Gln Ala Lys 
                405                 410                 415     


Leu Asp Ser Leu His Leu Pro Ala Gly Arg Ala Ala Tyr Ser Arg Glu 
            420                 425                 430         


Ser Leu Thr Ala Leu Ser Asp His Met Leu Ala Thr Thr Asp Asp Leu 
        435                 440                 445             


His Glu Ala Arg Lys Arg Leu Phe Gly Val Asp Asp Ser Trp Ala Pro 
    450                 455                 460                 


Pro Ala Glu Ala Ile Asn Ala Pro Val Gly Asn Pro Ser Val Asp Arg 
465                 470                 475                 480 


Thr Leu Lys Ile Val Gly Arg Tyr Leu Ser Ala Val Glu Ser Met Trp 
                485                 490                 495     


Gly Thr Pro Glu Val Ile His Val Glu His Val Arg Asp Gly Phe Thr 
            500                 505                 510         


Ser Glu Arg Met Ala Asp Glu Arg Asp Lys Ala Asn Arg Arg Arg Tyr 
        515                 520                 525             


Asn Asp Asn Gln Glu Ala Met Lys Lys Ile Gln Arg Asp Tyr Gly Lys 
    530                 535                 540                 


Glu Gly Tyr Ile Ser Arg Gly Asp Ile Val Arg Leu Asp Ala Leu Glu 
545                 550                 555                 560 


Leu Gln Gly Cys Ala Cys Leu Tyr Cys Gly Thr Thr Ile Gly Tyr His 
                565                 570                 575     


Thr Cys Gln Leu Asp His Ile Val Pro Gln Ala Gly Pro Gly Ser Asn 
            580                 585                 590         


Asn Arg Arg Gly Asn Leu Val Ala Val Cys Glu Arg Cys Asn Arg Ser 
        595                 600                 605             


Lys Ser Asn Thr Pro Phe Ala Val Trp Ala Gln Lys Cys Gly Ile Pro 
    610                 615                 620                 


His Val Gly Val Lys Glu Ala Ile Gly Arg Val Arg Gly Trp Arg Lys 
625                 630                 635                 640 


Gln Thr Pro Asn Thr Ser Ser Glu Asp Leu Thr Arg Leu Lys Lys Glu 
                645                 650                 655     


Val Ile Ala Arg Leu Arg Arg Thr Gln Glu Asp Pro Glu Ile Asp Glu 
            660                 665                 670         


Arg Ser Met Glu Ser Val Ala Trp Met Ala Asn Glu Leu His His Arg 
        675                 680                 685             


Ile Ala Ala Ala Tyr Pro Glu Thr Thr Val Met Val Tyr Arg Gly Ser 
    690                 695                 700                 


Ile Thr Ala Ala Ala Arg Lys Ala Ala Gly Ile Asp Ser Arg Ile Asn 
705                 710                 715                 720 


Leu Ile Gly Glu Lys Gly Arg Lys Asp Arg Ile Asp Arg Arg His His 
                725                 730                 735     


Ala Val Asp Ala Ser Val Val Ala Leu Met Glu Ala Ser Val Ala Lys 
            740                 745                 750         


Thr Leu Ala Glu Arg Ser Ser Leu Arg Gly Glu Gln Arg Leu Thr Gly 
        755                 760                 765             


Lys Glu Gln Thr Trp Lys Gln Tyr Thr Gly Ser Thr Val Gly Ala Arg 
    770                 775                 780                 


Glu His Phe Glu Met Trp Arg Gly His Met Leu His Leu Thr Glu Leu 
785                 790                 795                 800 


Phe Asn Glu Arg Leu Ala Glu Asp Lys Val Tyr Val Thr Gln Asn Ile 
                805                 810                 815     


Arg Leu Arg Leu Ser Asp Gly Asn Ala His Thr Val Asn Pro Ser Lys 
            820                 825                 830         


Leu Val Ser His Arg Leu Gly Asp Gly Leu Thr Val Gln Gln Ile Asp 
        835                 840                 845             


Arg Ala Cys Thr Pro Ala Leu Trp Cys Ala Leu Thr Arg Glu Lys Asp 
    850                 855                 860                 


Phe Asp Glu Lys Asn Gly Leu Pro Ala Arg Glu Asp Arg Ala Ile Arg 
865                 870                 875                 880 


Val His Gly His Glu Ile Lys Ser Ser Asp Tyr Ile Gln Val Phe Ser 
                885                 890                 895     


Lys Arg Lys Lys Thr Asp Ser Asp Arg Asp Glu Thr Pro Phe Gly Ala 
            900                 905                 910         


Ile Ala Val Arg Gly Gly Phe Val Glu Ile Gly Pro Ser Ile His His 
        915                 920                 925             


Ala Arg Ile Tyr Arg Val Glu Gly Lys Lys Pro Val Tyr Ala Met Leu 
    930                 935                 940                 


Arg Val Phe Thr His Asp Leu Leu Ser Gln Arg His Gly Asp Leu Phe 
945                 950                 955                 960 


Ser Ala Val Ile Pro Pro Gln Ser Ile Ser Met Arg Cys Ala Glu Pro 
                965                 970                 975     


Lys Leu Arg Lys Ala Ile Thr Thr Gly Asn Ala Thr Tyr Leu Gly Trp 
            980                 985                 990         


Val Val Val Gly Asp Glu Leu Glu  Ile Asn Val Asp Ser  Phe Thr Lys 
        995                 1000                 1005             


Tyr Ala  Ile Gly Arg Phe Leu  Glu Asp Phe Pro Asn  Thr Thr Arg 
    1010                 1015                 1020             


Trp Arg  Ile Cys Gly Tyr Asp  Thr Asn Ser Lys Leu  Thr Leu Lys 
    1025                 1030                 1035             


Pro Ile  Val Leu Ala Ala Glu  Gly Leu Glu Asn Pro  Ser Ser Ala 
    1040                 1045                 1050             


Val Asn  Glu Ile Val Glu Leu  Lys Gly Trp Arg Val  Ala Ile Asn 
    1055                 1060                 1065             


Val Leu  Thr Lys Val His Pro  Thr Val Val Arg Arg  Asp Ala Leu 
    1070                 1075                 1080             


Gly Arg  Pro Arg Tyr Ser Ser  Arg Ser Asn Leu Pro  Thr Ser Trp 
    1085                 1090                 1095             


Thr Ile  Glu 
    1100     


<210> 52
<211> 1144
<212> PRT
<213> Actinomyces sp.


<220>
<223> Actinomyces sp. ICM47

<400> 52
Met Ser Met Ile Asp Ser Ser Glu Asn Val Pro Gly Ile Arg Tyr Arg 
1               5                   10                  15      


Val Gly Ile Asp Val Gly Leu Lys Ser Ile Gly Phe Cys Ala Val Glu 
            20                  25                  30          


Val Asp Arg Asn Asp Gln Pro Val Arg Met Leu Asn Ser Met Val Phe 
        35                  40                  45              


Ile His Asp Ala Gly Val Asp Pro Asn Glu Asn Lys Ala Ala Lys Ser 
    50                  55                  60                  


Arg Lys Leu Thr Ala Gly Val Ala Arg Arg Thr Arg Arg Leu Tyr Arg 
65                  70                  75                  80  


Thr Arg His Gln Arg Leu Val Asn Leu Asp Arg Val Leu Ser Lys Glu 
                85                  90                  95      


Phe Gly Trp Pro Leu Pro Asp Leu Thr Ser Phe Lys Asp Pro Arg Glu 
            100                 105                 110         


Pro Trp His Val Arg Ala Gly Leu Leu Glu Gly Tyr Ile Ala Asp Asp 
        115                 120                 125             


Glu Lys Arg Lys Glu Ala Leu Ser Ile Ala Leu Arg His Ile Ala Arg 
    130                 135                 140                 


His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Glu Thr Leu Leu Gln 
145                 150                 155                 160 


Pro Ser Glu Pro Ser Asp Phe Leu Lys Gly Leu Asn Asp Arg Ile Ser 
                165                 170                 175     


Glu Glu Leu Gly Arg Ala Phe Pro Ala Asp Ala Thr Pro Gly Gln Leu 
            180                 185                 190         


Val Asp Thr Tyr Leu Ala His Pro Asp Tyr Val Gly Arg Ala Gly Thr 
        195                 200                 205             


Pro Lys Leu Arg Gly Pro Gln Gly Ile Leu Ala Gly Lys Leu His Gln 
    210                 215                 220                 


Ser Asp Asn Ala Gln Glu Ile Arg Gly Ile Cys Asp Val Gln Arg Ile 
225                 230                 235                 240 


Glu Pro Ala Glu Arg Asp Arg Leu Ile Arg Val Val Phe Glu Ala Lys 
                245                 250                 255     


Ser Pro Lys Gly Ser Ala Lys Glu Arg Gly Leu Val Gly Tyr Asp Glu 
            260                 265                 270         


Leu Pro Gly Gln Gly Arg His Val Arg Ala Glu Lys Ala His Pro Ala 
        275                 280                 285             


Phe Gln Leu Phe Arg Met Val Ser Val Leu Ala Asn Leu Arg Ile Arg 
    290                 295                 300                 


Glu Gly Arg Glu Glu Arg Pro Leu Thr Pro Asp Glu Leu Glu Asp Leu 
305                 310                 315                 320 


Val Asp Phe Ile Asn Gln Val Ser Leu Lys Gln Glu Val Thr Trp Gln 
                325                 330                 335     


Asp Leu Ala Asp Lys Leu Arg Ile Glu Arg Ala Asp Leu Arg Gly Thr 
            340                 345                 350         


Ala Lys Ala Ser Phe Asp Gly Ser Pro Val Leu Arg Asn Pro Pro Thr 
        355                 360                 365             


Asp Val Thr Thr Glu Lys Ile Met Ala Cys Lys Val Lys Trp Leu Lys 
    370                 375                 380                 


Glu Trp Trp Lys Glu Ala Asp Asp Glu Gln Arg Gly Tyr Met Val Asp 
385                 390                 395                 400 


Ala Phe Ser Asn Ser Gly Gly Ser Glu Asp Gly Thr Asp Val Asn Asp 
                405                 410                 415     


Glu Val Ala Glu Leu Leu Glu Gln Ala Thr Glu Asp Asp Gln Leu Glu 
            420                 425                 430         


Phe Glu Lys Ile Ser Leu Pro Gln Gly Arg Ala Ala Tyr Ser Leu Asp 
        435                 440                 445             


Ser Leu Arg Arg Leu Thr Asp Arg Met Leu Arg Asp Gly Val Asp Leu 
    450                 455                 460                 


His Thr Ala Arg Arg Leu Glu Phe Asn Val Gly Asp Asp Trp Lys Pro 
465                 470                 475                 480 


Ala Val Glu Pro Ile Gly Ala Pro Thr Gly Asn Pro Ala Val Asp Arg 
                485                 490                 495     


Val Leu Lys Gln Val Ser Arg Trp Leu His Ala Ala Thr Glu Arg Trp 
            500                 505                 510         


Gly Glu Pro Thr Val Ile Asn Ile Glu His Ala Arg Asp Gly Leu Gly 
        515                 520                 525             


Ser Glu Arg Val Ala Arg Glu Leu Met Arg Glu Asn Glu Lys Arg Arg 
    530                 535                 540                 


Lys Ala Asn Ala Ser Ala Val Ala Glu Met Ala Ala Lys Leu Lys Leu 
545                 550                 555                 560 


Ser Gly Lys Val His Arg Ser Asp Gln Ile Arg Tyr Phe Ala Leu Gln 
                565                 570                 575     


Arg Gln Asn Cys Gln Cys Leu Tyr Cys Gly Ala Pro Ile Thr Tyr Thr 
            580                 585                 590         


Thr Ala Glu Met Asp His Ile Val Pro Arg Ala Asp Gly Ser Ser Thr 
        595                 600                 605             


Asn Asp Arg Ser Asn Leu Ala Ala Val Cys Arg Thr Cys Asn His Met 
    610                 615                 620                 


Lys Gly Lys Ile Pro Phe Ala Val Trp Ala Ser Ser Asp Lys Ala Asn 
625                 630                 635                 640 


Gln Gly Val Ser Leu Thr Gly Ala Leu Glu Arg Val Asn Met Trp Gln 
                645                 650                 655     


Arg Asp Ser Gly Met Ser Pro Arg Gln Leu Lys Gln Leu Gln Arg Glu 
            660                 665                 670         


Val Cys Ala Arg Leu Lys Ser Lys Lys Pro Asp Gln Glu Phe Asp Gly 
        675                 680                 685             


Arg Ser Met Glu Ser Val Ala Trp Met Ala Val Glu Leu Arg Thr Arg 
    690                 695                 700                 


Ile Glu Gly Phe Tyr Arg Ser Arg Asp Glu Glu Ser Val Pro Ser Val 
705                 710                 715                 720 


Gly Val Tyr Arg Gly Gln Leu Thr Ala Glu Ala Arg Arg Ala Ser Gly 
                725                 730                 735     


Phe Glu Ser Arg Val Asn Leu Ile Gly Gly Arg Gly Lys Thr Arg Phe 
            740                 745                 750         


Asp Arg Arg His His Ala Met Asp Ala Leu Val Ile Ala Leu Met Asn 
        755                 760                 765             


Pro Ser Val Ser Arg Thr Leu Ala Leu Arg Leu Asn Met Arg Asp Ala 
    770                 775                 780                 


Gln Arg Leu Thr Gly Val Glu Glu Thr Trp Lys His Phe Tyr Gly Lys 
785                 790                 795                 800 


Pro Gly Glu Ala Ser Lys Arg Phe Glu Ser Trp Arg Glu Ser Met Leu 
                805                 810                 815     


Arg Gly Val Glu Leu Phe Asn Ile Ala Leu Ser Asp Asn Ala Ile Pro 
            820                 825                 830         


Phe Val Glu Asn Ile Arg Leu Arg Val Gly Ser Ser Val Ile His Asp 
        835                 840                 845             


Ala Thr Val His Ser Phe Cys Pro Pro Lys Thr Pro Asp Gly Lys Gln 
    850                 855                 860                 


Ile Ile Thr Lys Gly Tyr Gly Glu Gln His Ser Leu Gly Ser Ala Met 
865                 870                 875                 880 


Pro Val Glu Leu Ile Asp Arg Ala Glu Thr Pro Ala Leu Trp Thr Ala 
                885                 890                 895     


Leu Thr Arg Cys Pro Asp Phe Asp Pro Lys Lys Gly Leu Pro Glu Asn 
            900                 905                 910         


Pro Gln Arg Thr Ile Ser Val Asn Gly Thr Arg Val Gly Pro Thr Glu 
        915                 920                 925             


Leu Val Asn Phe Phe Glu Phe Ser Lys Ser Gly Pro Lys Ala Cys Leu 
    930                 935                 940                 


Lys Val Arg Gly Gly Tyr Val Asp Leu Ser Gly Ala Ile His His Ala 
945                 950                 955                 960 


Arg Ile Tyr Arg Ile Ala Gly Lys Lys Thr Ala Tyr Ala Met Ile Arg 
                965                 970                 975     


Val Phe Gln Val Asp Leu Leu Arg Leu Lys Asp His Asp Val Phe Thr 
            980                 985                 990         


Thr Pro Leu Lys Pro Ser Thr Ile  Ser Met Arg Thr Ala  Glu Pro Lys 
        995                 1000                 1005             


Ile Arg  Glu Ala Leu Ala Asn  Gly Thr Ala Thr Gln  Ile Gly Trp 
    1010                 1015                 1020             


Leu Val  Glu Gly Asp Glu Leu  Val Ile Asp Thr Ser  Lys Tyr Ser 
    1025                 1030                 1035             


Gly Gly  Phe Ile Gly Glu Val  Leu Ala Arg Tyr Pro  Glu Ala Thr 
    1040                 1045                 1050             


Ser Trp  Arg Val Ala Gly Phe  Met Thr Pro Ala Lys  Leu Arg Ile 
    1055                 1060                 1065             


Lys Pro  Ile Leu Leu Ser Lys  Glu Gly Phe Val Asp  Glu Thr Gln 
    1070                 1075                 1080             


Ala Ala  Leu Leu Gly Val Glu  Val Thr Ser Glu Ala  Ile Gln Lys 
    1085                 1090                 1095             


Thr Val  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Val Leu Phe 
    1100                 1105                 1110             


Gly Ala  Gly Gly Val Arg Val  Ile Arg Arg Asn Cys  Leu Gly Glu 
    1115                 1120                 1125             


Glu Arg  Tyr His Ser Ser Ala  Ser Leu Pro Val Ser  Met Thr Leu 
    1130                 1135                 1140             


Glu 
    


<210> 53
<211> 1095
<212> PRT
<213> Actinomyces sp.


<220>
<223> Actinomyces sp. oral taxon 175 str. F0384

<400> 53
Met Pro Ala His His Leu Arg Val Gly Ile Asp Val Gly Thr His Ser 
1               5                   10                  15      


Val Gly Leu Ala Thr Leu Arg Val Asp Asp Gln Gly Thr Pro Ile Glu 
            20                  25                  30          


Leu Leu Ser Ala Leu Ser His Ile His Asp Ser Gly Ile Gly Lys Glu 
        35                  40                  45              


Gly Gln Lys Asp His Asp Thr Arg Lys Lys Leu Ser Gly Val Ala Arg 
    50                  55                  60                  


Arg Thr Arg His Leu Leu Arg Asn Arg Arg Glu Arg Leu Gln Gln Leu 
65                  70                  75                  80  


Asp Lys Val Leu Val Asp Leu Gly Phe Pro Ile Pro Lys Pro Glu Glu 
                85                  90                  95      


Tyr Pro Asp Leu Ser Glu Arg Thr Asp Pro Tyr Arg Val Trp Arg Val 
            100                 105                 110         


Arg Ala Arg Leu Val Glu Glu Thr Leu Pro Glu Glu Leu Arg Gly Pro 
        115                 120                 125             


Ala Ile Ser Met Ala Val Arg His Ile Ala Arg His Arg Gly Trp Arg 
    130                 135                 140                 


Asn Pro Tyr Ser Lys Val Glu Ser Leu Leu Ser Pro Ala Glu Glu Ser 
145                 150                 155                 160 


Ser Phe Met Lys Ala Leu Arg Lys Arg Ile Met Thr Lys Thr Gly Glu 
                165                 170                 175     


Val Leu Asp Asp Asp Ile Thr Pro Gly Gln Ala Met Ala Gln Val Ala 
            180                 185                 190         


Leu Thr His Lys Ile Tyr Met Arg Gly Pro Glu Gly Ile Leu Gly Lys 
        195                 200                 205             


Leu His Gln Ser Asp Asn Ala Asn Glu Ile Arg Lys Ile Cys Ala Arg 
    210                 215                 220                 


Gln Gly Ile Ser Ser Asp Val Cys Lys Gln Leu Leu Arg Ala Val Phe 
225                 230                 235                 240 


Lys Ala Glu Ser Pro Arg Gly Ser Ala Val Ser Arg Val Ala Pro Asp 
                245                 250                 255     


Pro Leu Pro Gly Gln Gly Ser Phe Arg Arg Ala Pro Lys Cys Asp Pro 
            260                 265                 270         


Glu Phe Gln Arg Phe Arg Ile Ile Ser Ile Val Ala Asn Leu Arg Ile 
        275                 280                 285             


Ser Glu Thr Lys Gly Glu Asn Arg Pro Leu Thr Val Asp Glu Arg Arg 
    290                 295                 300                 


Gln Val Val Ala Phe Leu Met Glu Asp Ser Gln Ala Asp Leu Thr Trp 
305                 310                 315                 320 


Val Asp Val Ala Glu Lys Leu Arg Val Ser Arg Gln Ala Leu Arg Gly 
                325                 330                 335     


Thr Ala Met Leu Thr Ala Asp Gly Glu Arg Ser Ala Ala Gln Pro Pro 
            340                 345                 350         


Ile Asp Val Thr Asp Gln Ile Met Arg Lys Thr Lys Ile Ser Ala Leu 
        355                 360                 365             


Lys Thr Trp Trp Asp Lys Ala Asp Ala Glu Arg Arg Gly Ala Met Val 
    370                 375                 380                 


Arg Tyr Leu Tyr Glu Gly Leu Glu Asp Ser Glu Cys Ala Glu Val Ile 
385                 390                 395                 400 


Ala Lys Leu Pro Glu Lys Asp His Ala Lys Leu Asp Ser Leu His Leu 
                405                 410                 415     


Pro Ala Gly Arg Ala Ala Tyr Ser Arg Glu Ser Leu Thr Ala Leu Ser 
            420                 425                 430         


Asp His Met Leu Glu Thr Thr Asn Asp Leu His Glu Ala Arg Lys Arg 
        435                 440                 445             


Leu Phe Gly Val Asp Asp Ser Trp Ala Pro Pro Ala Glu Pro Val Gly 
    450                 455                 460                 


Ala Pro Val Gly Asn Pro Ser Val Asp Arg Thr Leu Lys Ile Val Ala 
465                 470                 475                 480 


Arg Tyr Leu Ser Ala Val Glu Ser Ile Trp Gly Thr Pro Glu Val Ile 
                485                 490                 495     


His Val Glu His Val Arg Asp Gly Phe Thr Ser Glu Arg Thr Ala Glu 
            500                 505                 510         


Glu Arg Asp Lys Ala Asn Arg Ser Arg His Asn Asp Asn Gln Lys Ala 
        515                 520                 525             


Ile Glu Lys Ile Gln His Asp Tyr Gly Lys Glu Gly Tyr Ile Ser Arg 
    530                 535                 540                 


Gly Asp Ile Val Arg Phe His Ala Leu Lys Leu Gln Gly Ser Ala Cys 
545                 550                 555                 560 


Leu Tyr Cys Gly Thr Thr Ile Gly Tyr His Thr Cys Gln Leu Asp His 
                565                 570                 575     


Ile Val Pro Gln Ala Gly Pro Gly Ser Asn Asn Arg Arg Gly Asn Leu 
            580                 585                 590         


Val Ala Val Cys Glu Arg Cys Asn His Ser Lys Ser Asn Thr Pro Phe 
        595                 600                 605             


Ala Val Trp Ala Gln Lys Cys Gly Ile Pro His Val Gly Val Lys Glu 
    610                 615                 620                 


Ala Ile Ser Arg Val Asn Gly Trp Val Glu His Asn His Ser Thr Ser 
625                 630                 635                 640 


Ser Gly Asp Leu Thr Arg Leu Lys Lys Glu Val Ile Ala Arg Leu Arg 
                645                 650                 655     


Arg Thr Gln Lys Asp Pro Glu Ile Asp Glu Arg Ser Met Glu Ser Val 
            660                 665                 670         


Ala Trp Met Ala Asn Glu Leu His His Arg Ile Ala Ala Ala Tyr Pro 
        675                 680                 685             


Glu Thr Thr Val Met Val Tyr Arg Gly Ser Ile Thr Ala Ala Ala Arg 
    690                 695                 700                 


Lys Ala Ala Ser Ile Glu Ser Arg Ile Asn Leu Ile Gly Glu Lys Gly 
705                 710                 715                 720 


Arg Lys Asp Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ser Val 
                725                 730                 735     


Val Ala Leu Met Glu Pro Ser Val Ala Lys Thr Leu Ala Glu Arg Ser 
            740                 745                 750         


Ser Leu Arg Gly Glu Gln Arg Leu Thr Gly Gln Glu Gln Thr Trp Lys 
        755                 760                 765             


Gln Tyr Thr Gly Leu Thr Val Gly Ala Arg Glu Arg Phe Glu Ala Trp 
    770                 775                 780                 


Arg Gly His Met His Arg Leu Thr Glu Leu Phe Asn Glu Ser Leu Ala 
785                 790                 795                 800 


Ala Asp Glu Val Tyr Val Thr Gln Asn Ile Arg Leu Arg Leu Ser Asp 
                805                 810                 815     


Gly Ser Ala His Thr Val Lys Ala Ser Lys Leu Val Ser His Arg Leu 
            820                 825                 830         


Gly Asp Gly Leu Thr Val Gln Gln Ile Asp Arg Ala Cys Thr Pro Ala 
        835                 840                 845             


Leu Trp Cys Ala Leu Thr Arg Glu Ile Asp Phe Asp Glu Lys Asn Gly 
    850                 855                 860                 


Leu Pro Ala Arg Glu Asp Arg Val Ile Arg Val His Gly Gln Glu Ile 
865                 870                 875                 880 


Ser Ser Ala Asp Cys Ile Gln Val Phe Ser Lys Arg Lys Lys Thr Lys 
                885                 890                 895     


Ser Asp Arg Asp Glu Ala Pro Phe Gly Ala Ile Ala Val Arg Gly Gly 
            900                 905                 910         


Phe Val Glu Ile Gly Ser Ser Ile His His Ala Arg Ile Tyr Arg Ile 
        915                 920                 925             


Glu Gly Glu Lys Pro Ala Tyr Ala Met Leu Arg Val Phe Thr His Asp 
    930                 935                 940                 


Leu Leu Ser Gln Arg His Gly Asp Leu Phe Ser Ala Val Ile Pro Pro 
945                 950                 955                 960 


Gln Ser Ile Ser Met Arg Cys Ala Ala Thr Glu Leu Arg Gln Ala Ile 
                965                 970                 975     


Ser Glu Gly Arg Ala Thr Tyr Leu Gly Trp Ile Val Ser Gly Asp Glu 
            980                 985                 990         


Leu His Ile Pro Val Glu Thr Phe  Thr Thr His Lys Ile  Gly Ser Phe 
        995                 1000                 1005             


Leu Lys  Asp Tyr Pro Asn Thr  Thr Arg Trp Arg Ile  Cys Gly Tyr 
    1010                 1015                 1020             


Asp Ser  Glu Thr Met Leu Ile  Leu Lys Pro Arg Ile  Leu Ser Ala 
    1025                 1030                 1035             


Glu Gly  Leu Asn Asn Ser Ser  Asp Ile Ala Glu Tyr  Val Ile Lys 
    1040                 1045                 1050             


Asn Lys  Gly Trp Arg Val Ala  Ile Asn Lys Leu Ala  Lys Val His 
    1055                 1060                 1065             


Pro Thr  Val Val Arg Arg Asp  Ala Leu Gly Arg Pro  Arg His Ser 
    1070                 1075                 1080             


Ser Arg  Ser Asn Leu Pro Val  Thr Trp Ser Ile Glu  
    1085                 1090                 1095 


<210> 54
<211> 1181
<212> PRT
<213> Actinomyces sp.


<220>
<223> Actinomyces sp. oral taxon 180 str. F0310

<400> 54
Met Leu His Cys Ile Ala Val Ile Arg Val Pro Pro Ser Glu Glu Pro 
1               5                   10                  15      


Gly Phe Phe Glu Thr His Ala Asp Ser Cys Ala Leu Cys His His Gly 
            20                  25                  30          


Cys Met Thr Tyr Ala Ala Asn Asp Lys Ala Ile Arg Tyr Arg Val Gly 
        35                  40                  45              


Ile Asp Val Gly Leu Arg Ser Ile Gly Phe Cys Ala Val Glu Val Asp 
    50                  55                  60                  


Asp Glu Asp His Pro Ile Arg Ile Leu Asn Ser Val Val His Val His 
65                  70                  75                  80  


Asp Ala Gly Thr Gly Gly Pro Gly Glu Thr Glu Ser Leu Arg Lys Arg 
                85                  90                  95      


Ser Gly Val Ala Ala Arg Ala Arg Arg Arg Gly Arg Ala Glu Lys Gln 
            100                 105                 110         


Arg Leu Lys Lys Leu Asp Val Leu Leu Glu Glu Leu Gly Trp Gly Val 
        115                 120                 125             


Ser Ser Asn Glu Leu Leu Asp Ser His Ala Pro Trp His Ile Arg Lys 
    130                 135                 140                 


Arg Leu Val Ser Glu Tyr Ile Glu Asp Glu Thr Glu Arg Arg Gln Cys 
145                 150                 155                 160 


Leu Ser Val Ala Met Ala His Ile Ala Arg His Arg Gly Trp Arg Asn 
                165                 170                 175     


Ser Phe Ser Lys Val Asp Thr Leu Leu Leu Glu Gln Ala Pro Ser Asp 
            180                 185                 190         


Arg Met Gln Gly Leu Lys Glu Arg Val Glu Asp Arg Thr Gly Leu Gln 
        195                 200                 205             


Phe Ser Glu Glu Val Thr Gln Gly Glu Leu Val Ala Thr Leu Leu Glu 
    210                 215                 220                 


His Asp Gly Asp Val Thr Ile Arg Gly Phe Val Arg Lys Gly Gly Lys 
225                 230                 235                 240 


Ala Thr Lys Val His Gly Val Leu Glu Gly Lys Tyr Met Gln Ser Asp 
                245                 250                 255     


Leu Val Ala Glu Leu Arg Gln Ile Cys Arg Thr Gln Arg Val Ser Glu 
            260                 265                 270         


Thr Thr Phe Glu Lys Leu Val Leu Ser Ile Phe His Ser Lys Glu Pro 
        275                 280                 285             


Ala Pro Ser Ala Ala Arg Gln Arg Glu Arg Val Gly Leu Asp Glu Leu 
    290                 295                 300                 


Gln Leu Ala Leu Asp Pro Ala Ala Lys Gln Pro Arg Ala Glu Arg Ala 
305                 310                 315                 320 


His Pro Ala Phe Gln Lys Phe Lys Val Val Ala Thr Leu Ala Asn Met 
                325                 330                 335     


Arg Ile Arg Glu Gln Ser Ala Gly Glu Arg Ser Leu Thr Ser Glu Glu 
            340                 345                 350         


Leu Asn Arg Val Ala Arg Tyr Leu Leu Asn His Thr Glu Ser Glu Ser 
        355                 360                 365             


Pro Thr Trp Asp Asp Val Ala Arg Lys Leu Glu Val Pro Arg His Arg 
    370                 375                 380                 


Leu Arg Gly Ser Ser Arg Ala Ser Leu Glu Thr Gly Gly Gly Leu Thr 
385                 390                 395                 400 


Tyr Pro Pro Val Asp Asp Thr Thr Val Arg Val Met Ser Ala Glu Val 
                405                 410                 415     


Asp Trp Leu Ala Asp Trp Trp Asp Cys Ala Asn Asp Glu Ser Arg Gly 
            420                 425                 430         


His Met Ile Asp Ala Ile Ser Asn Gly Cys Gly Ser Glu Pro Asp Asp 
        435                 440                 445             


Val Glu Asp Glu Glu Val Asn Glu Leu Ile Ser Ser Ala Thr Ala Glu 
    450                 455                 460                 


Asp Met Leu Lys Leu Glu Leu Leu Ala Lys Lys Leu Pro Ser Gly Arg 
465                 470                 475                 480 


Val Ala Tyr Ser Leu Lys Thr Leu Arg Glu Val Thr Ala Ala Ile Leu 
                485                 490                 495     


Glu Thr Gly Asp Asp Leu Ser Gln Ala Ile Thr Arg Leu Tyr Gly Val 
            500                 505                 510         


Asp Pro Gly Trp Val Pro Thr Pro Ala Pro Ile Glu Ala Pro Val Gly 
        515                 520                 525             


Asn Pro Ser Val Asp Arg Val Leu Lys Gln Val Ala Arg Trp Leu Lys 
    530                 535                 540                 


Phe Ala Ser Lys Arg Trp Gly Val Pro Gln Thr Val Asn Ile Glu His 
545                 550                 555                 560 


Thr Arg Glu Gly Leu Lys Ser Ala Ser Leu Leu Glu Glu Glu Arg Glu 
                565                 570                 575     


Arg Trp Glu Arg Phe Glu Ala Arg Arg Glu Ile Arg Gln Lys Glu Met 
            580                 585                 590         


Tyr Lys Arg Leu Gly Ile Ser Gly Pro Phe Arg Arg Ser Asp Gln Val 
        595                 600                 605             


Arg Tyr Glu Ile Leu Asp Leu Gln Asp Cys Ala Cys Leu Tyr Cys Gly 
    610                 615                 620                 


Asn Glu Ile Asn Phe Gln Thr Phe Glu Val Asp His Ile Ile Pro Arg 
625                 630                 635                 640 


Val Asp Ala Ser Ser Asp Ser Arg Arg Thr Asn Leu Ala Ala Val Cys 
                645                 650                 655     


His Ser Cys Asn Ser Ala Lys Gly Gly Leu Ala Phe Gly Gln Trp Val 
            660                 665                 670         


Lys Arg Gly Asp Cys Pro Ser Gly Val Ser Leu Glu Asn Ala Ile Lys 
        675                 680                 685             


Arg Val Arg Ser Trp Ser Lys Asp Arg Leu Gly Leu Thr Glu Lys Ala 
    690                 695                 700                 


Met Gly Lys Arg Lys Ser Glu Val Ile Ser Arg Leu Lys Thr Glu Met 
705                 710                 715                 720 


Pro Tyr Glu Glu Phe Asp Gly Arg Ser Met Glu Ser Val Ala Trp Met 
                725                 730                 735     


Ala Ile Glu Leu Lys Lys Arg Ile Glu Gly Tyr Phe Asn Ser Asp Arg 
            740                 745                 750         


Pro Glu Gly Cys Ala Ala Val Gln Val Asn Ala Tyr Ser Gly Arg Leu 
        755                 760                 765             


Thr Ala Cys Ala Arg Arg Ala Ala His Val Asp Lys Arg Val Arg Leu 
    770                 775                 780                 


Ile Arg Leu Lys Gly Asp Asp Gly His His Lys Asn Arg Phe Asp Arg 
785                 790                 795                 800 


Arg Asn His Ala Met Asp Ala Leu Val Ile Ala Leu Met Thr Pro Ala 
                805                 810                 815     


Ile Ala Arg Thr Ile Ala Val Arg Glu Asp Arg Arg Glu Ala Gln Gln 
            820                 825                 830         


Leu Thr Arg Ala Phe Glu Ser Trp Lys Asn Phe Leu Gly Ser Glu Glu 
        835                 840                 845             


Arg Met Gln Asp Arg Trp Glu Ser Trp Ile Gly Asp Val Glu Tyr Ala 
    850                 855                 860                 


Cys Asp Arg Leu Asn Glu Leu Ile Asp Ala Asp Lys Ile Pro Val Thr 
865                 870                 875                 880 


Glu Asn Leu Arg Leu Arg Asn Ser Gly Lys Leu His Ala Asp Gln Pro 
                885                 890                 895     


Glu Ser Leu Lys Lys Ala Arg Arg Gly Ser Lys Arg Pro Arg Pro Gln 
            900                 905                 910         


Arg Tyr Val Leu Gly Asp Ala Leu Pro Ala Asp Val Ile Asn Arg Val 
        915                 920                 925             


Thr Asp Pro Gly Leu Trp Thr Ala Leu Val Arg Ala Pro Gly Phe Asp 
    930                 935                 940                 


Ser Gln Leu Gly Leu Pro Ala Asp Leu Asn Arg Gly Leu Lys Leu Arg 
945                 950                 955                 960 


Gly Lys Arg Ile Ser Ala Asp Phe Pro Ile Asp Tyr Phe Pro Thr Asp 
                965                 970                 975     


Ser Pro Ala Leu Ala Val Gln Gly Gly Tyr Val Gly Leu Glu Phe His 
            980                 985                 990         


His Ala Arg Leu Tyr Arg Ile Ile  Gly Pro Lys Glu Lys  Val Lys Tyr 
        995                 1000                 1005             


Ala Leu  Leu Arg Val Cys Ala  Ile Asp Leu Cys Gly  Ile Asp Cys 
    1010                 1015                 1020             


Asp Asp  Leu Phe Glu Val Glu  Leu Lys Pro Ser Ser  Ile Ser Met 
    1025                 1030                 1035             


Arg Thr  Ala Asp Ala Lys Leu  Lys Glu Ala Met Gly  Asn Gly Ser 
    1040                 1045                 1050             


Ala Lys  Gln Ile Gly Trp Leu  Val Leu Gly Asp Glu  Ile Gln Ile 
    1055                 1060                 1065             


Asp Pro  Thr Lys Phe Pro Lys  Gln Ser Ile Gly Lys  Phe Leu Lys 
    1070                 1075                 1080             


Glu Cys  Gly Pro Val Ser Ser  Trp Arg Val Ser Ala  Leu Asp Thr 
    1085                 1090                 1095             


Pro Ser  Lys Ile Thr Leu Lys  Pro Arg Leu Leu Ser  Asn Glu Pro 
    1100                 1105                 1110             


Leu Leu  Lys Thr Ser Arg Val  Gly Gly His Glu Ser  Asp Leu Val 
    1115                 1120                 1125             


Val Ala  Glu Cys Val Glu Lys  Ile Met Lys Lys Thr  Gly Trp Val 
    1130                 1135                 1140             


Val Glu  Ile Asn Ala Leu Cys  Gln Ser Gly Leu Ile  Arg Val Ile 
    1145                 1150                 1155             


Arg Arg  Asn Ala Leu Gly Glu  Val Arg Thr Ser Pro  Lys Ser Gly 
    1160                 1165                 1170             


Leu Pro  Ile Ser Leu Asn Leu  Arg 
    1175                 1180     


<210> 55
<211> 1103
<212> PRT
<213> Actinomyces sp.


<220>
<223> Actinomyces sp. oral taxon 181 str. F0379

<400> 55
Met Thr Lys Ile Asn Asp Asp Leu Arg Tyr Arg Val Gly Ile Asp Val 
1               5                   10                  15      


Gly Leu Lys Ser Ile Gly Phe Cys Ala Val Glu Val Asp Glu Asn Asp 
            20                  25                  30          


Gln Pro Leu Arg Leu Leu Asn Ser Met Val Phe Val His Asp Ala Gly 
        35                  40                  45              


Val Asp Pro Asn Glu Asn Lys Ala Ala Lys Ser Arg Lys Leu Thr Ala 
    50                  55                  60                  


Gly Val Ala Arg Arg Thr Gln Arg Gly Thr Ala Gln Asn Arg Arg Arg 
65                  70                  75                  80  


Leu Ala Glu Leu Asp Arg Ala Leu Ser Glu Glu Leu Asn Trp Pro Leu 
                85                  90                  95      


Pro Asn Leu Glu Asp Phe Glu Asp Ser Tyr Glu Pro Trp His Thr Arg 
            100                 105                 110         


Ala Glu Leu Val Glu His Tyr Ile Lys Asp Asp Ala Glu Arg Ala Glu 
        115                 120                 125             


Ala Leu Ala Ile Ala Ile Arg His Ile Ala Arg His Arg Gly Trp Arg 
    130                 135                 140                 


Asn Pro Tyr Leu Ser Val Asp Ser Leu Leu Thr Pro Gln Glu Pro Ser 
145                 150                 155                 160 


Lys Phe Leu Arg Gly Leu Asn Glu Arg Val Thr Gln Ala Leu Gly Arg 
                165                 170                 175     


Glu Phe Pro Ala Asp Ala Thr Pro Gly Gln Leu Ile Cys Ala Tyr Ile 
            180                 185                 190         


Asp Ser Pro Lys Tyr Ala Glu Thr Gln Gly Ile Arg Gly Asp Ser Gly 
        195                 200                 205             


Ile Leu Ser Gly Lys Leu His Gln Phe Asp Asn Val Gly Glu Ile Arg 
    210                 215                 220                 


Lys Ile Cys Glu Val Gln Arg Leu Asp His Asp Val Phe Lys Leu Leu 
225                 230                 235                 240 


Val Arg Lys Val Phe Phe Ala Lys Ser Pro Arg Gly Ser Ala Ala Gly 
                245                 250                 255     


Leu Val Gly His Asp Gln Ile Pro Gly Gln Gly Lys Tyr Ile Arg Ala 
            260                 265                 270         


Glu Lys Ala His Pro Asp Phe Gln Leu Phe Arg Ile Val Ala Val Leu 
        275                 280                 285             


Thr Asn Leu Arg Ile Arg Glu Gly Lys Ala Glu Arg Cys Leu Thr Pro 
    290                 295                 300                 


Asp Glu Leu Arg Gly Leu Val Asp Tyr Ile Leu Glu Val Gln Leu Lys 
305                 310                 315                 320 


Gln Gln Val Thr Trp Ala Asp Leu Ala Asp Asn Leu Gly Ile Glu Arg 
                325                 330                 335     


Thr Asp Leu Arg Gly Thr Ala Arg Ala Ser Phe Asp Gly Ser Pro Ala 
            340                 345                 350         


Leu Arg Phe Pro Pro Thr Asp Val Thr Ala Glu Lys Ile Met Ala Ser 
        355                 360                 365             


Lys Val Lys Trp Leu Lys Asp Trp Trp Asp Lys Ala Asp Ser Glu Arg 
    370                 375                 380                 


Arg Gly Phe Met Val Asp Ala Leu Ser Asn Ser Gly Gly Ser Thr Gly 
385                 390                 395                 400 


Asp Asn Asp Ile Asp Asp Glu Val Ala Ala Leu Leu Glu Ala Ala Thr 
                405                 410                 415     


Glu Asp Glu Gln Ala Glu Leu Glu Lys Ile Gln Leu Pro Gln Gly Arg 
            420                 425                 430         


Ala Ala Tyr Ser Leu Asp Ser Leu Arg Arg Leu Thr Lys Arg Met Leu 
        435                 440                 445             


Glu Glu Gly Val Asp Leu His Thr Ala Arg Lys Glu Glu Phe Asn Val 
    450                 455                 460                 


Asp Asp Asp Trp Arg Pro Glu Pro Glu Pro Ile Glu Ala Pro Val Gly 
465                 470                 475                 480 


Asn Pro Ala Val Asp Arg Val Leu Lys Gln Val Ala Arg Trp Leu Asn 
                485                 490                 495     


Met Ala Thr Asp Arg Trp Gly Val Pro Asp Val Ile Asn Ile Glu His 
            500                 505                 510         


Thr Arg Asp Gly Leu Gly Ser Glu Lys Val Ala Arg Glu Leu Leu Arg 
        515                 520                 525             


Glu Ser Gln Lys Arg Gln Asp Leu Asn Gln Lys Asp Met Asp Lys Met 
    530                 535                 540                 


Ile Arg Glu Leu Gly Ile Ser Gly Lys Ala Arg Arg Ser Ser Leu Ile 
545                 550                 555                 560 


Lys Tyr Gln Ala Ile Gln Arg Gln Asn Ser Met Cys Leu Tyr Cys Gly 
                565                 570                 575     


Thr Glu Ile Gly Phe Glu Thr Ala Glu Met Asp His Ile Val Pro Arg 
            580                 585                 590         


Ala Leu Ser Gly Ser Thr Asn Asp Arg Ser Asn Leu Ala Ala Val Cys 
        595                 600                 605             


Arg Ala Cys Asn His Gln Lys Gly Ala Val Pro Phe Ala Val Trp Ala 
    610                 615                 620                 


Thr Ser Gly Glu Ala His Ala Gly Val Ser Leu Glu Asp Ala Ile Lys 
625                 630                 635                 640 


Arg Val Arg Leu Trp Gln Lys Gly Pro Gly Met Ser Pro Lys Gln His 
                645                 650                 655     


Lys Ala Phe Gln Asn Glu Val Ile Ser Arg Leu Lys Ser Arg Lys Pro 
            660                 665                 670         


Asp Glu Glu Phe Asp Gly Arg Ser Met Glu Ser Val Ala Trp Met Ala 
        675                 680                 685             


Val Glu Leu Arg Thr Arg Ile Asp Gly Tyr Tyr Arg Lys Val Asn Ser 
    690                 695                 700                 


Asp Ser Val Pro Lys Val Gly Ile Tyr Arg Gly Gln Leu Thr Ala Glu 
705                 710                 715                 720 


Ala Arg Lys Ala Ser Gly Phe Glu Asn Arg Val Asn Leu Ile Gly Gly 
                725                 730                 735     


Lys Gly Lys Thr Arg Phe Asp Arg Arg His His Ala Met Asp Ala Leu 
            740                 745                 750         


Val Ile Ala Met Met Asn Gln Ser Val Ser Gln Thr Leu Ala Leu Arg 
        755                 760                 765             


Val Asn Met Arg Glu Ser Gln Arg Ile Thr Gly Gln Glu Glu Thr Trp 
    770                 775                 780                 


Lys Asn Phe Tyr Gly Lys Pro Gly Gln Ala Ser Glu Arg Phe Glu Lys 
785                 790                 795                 800 


Trp Arg Glu Gly Met Leu Arg Ala Val Glu Leu Phe Asn Ile Glu Leu 
                805                 810                 815     


Ala Lys Asn Ala Ile Pro Phe His Glu Asn Val Arg Leu Arg Val Gly 
            820                 825                 830         


Ser Ser Lys Val His Asp Asp Thr Val Arg Lys Phe Ile His Ala Lys 
        835                 840                 845             


Leu Gly Glu Ala Leu Ser Val Ala Met Ile Asp Cys Ala Glu Thr Pro 
    850                 855                 860                 


Ala Leu Trp Thr Ala Leu Thr Arg Leu Pro Asp Phe Asp Pro Lys Asp 
865                 870                 875                 880 


Gly Leu Pro Glu Asp Leu Ser Arg Glu Ile Tyr Ile His Ser Arg Lys 
                885                 890                 895     


Ile Thr Ala Asp Glu Gln Leu Asn Phe Phe Asn Ser Pro Ser Ala Cys 
            900                 905                 910         


Leu Lys Val Arg Gly Gly Tyr Val Glu Ile Gly Ser Ser Ile His His 
        915                 920                 925             


Ala Arg Val Tyr Arg Ile Asp Gly Lys Lys Thr Thr Tyr Ser Met Val 
    930                 935                 940                 


Arg Val Phe Ala Thr Asp Leu Val Lys Met Thr His Glu Asp Val Phe 
945                 950                 955                 960 


Thr Thr Pro Leu Lys Pro Ser Thr Ile Ser Met Arg Thr Ala Asp Pro 
                965                 970                 975     


Lys Ile Arg Lys Ala Leu Ala Asp Gly Thr Ala Thr Gln Ile Gly Trp 
            980                 985                 990         


Leu Val Glu Gly Asp Glu Leu Gln  Leu Glu Thr Asp Lys  Tyr Ser Gly 
        995                 1000                 1005             


Gly Leu  Ile Gly Glu Val Leu  Ala Glu Tyr Pro Gln  Leu Thr Ser 
    1010                 1015                 1020             


Trp Arg  Val Ala Gly Phe Tyr  Gly Val Thr Gln Leu  Arg Leu Arg 
    1025                 1030                 1035             


Pro Tyr  Met Leu Ala Ala Glu  Gly Ile Pro Ser Asp  Ala Ser Glu 
    1040                 1045                 1050             


Ser Leu  Arg Lys Val Ile Glu  Gly Lys Gly Trp Leu  Pro Ala Ile 
    1055                 1060                 1065             


Asn Ala  Leu Leu Ser Ser Gly  Cys Val Lys Val Val  Arg Arg Asn 
    1070                 1075                 1080             


Cys Leu  Gly Glu Pro Arg Phe  Asn Ala Lys Ser Ser  Leu Pro Val 
    1085                 1090                 1095             


Ser Gln  Leu Leu Arg 
    1100             


<210> 56
<211> 1120
<212> PRT
<213> Actinomyces sp.


<220>
<223> Actinomyces sp. oral taxon 848 str. F0332

<400> 56
Met Asn Ala Met Lys Gln Tyr Asn Ala Gly Ile Asp Val Gly Ile Asn 
1               5                   10                  15      


Ser Val Gly Phe Ala Ala Ile Glu Val Asp Ser Lys Gly Leu Pro Leu 
            20                  25                  30          


Asn Ile Leu Asn Asn Met Val Val Leu His Asp Ser Gly Val Asp Pro 
        35                  40                  45              


Gly Thr Ala Lys Thr Gly Ala Thr Arg Leu Ala Asn Ser Gly Thr Ala 
    50                  55                  60                  


Arg Arg Thr Arg Lys Leu Ile Ala Arg Arg Arg Lys Arg Leu Gln Lys 
65                  70                  75                  80  


Leu Asp Arg Tyr Ile Glu Val Gln Gly Trp Pro Leu Val Asp Phe Ser 
                85                  90                  95      


Ser Leu Pro Asp Pro Tyr Thr Pro Trp Lys Ile Arg Ala Lys Leu Thr 
            100                 105                 110         


Gln Asp Arg Leu Glu Gly Glu Glu Gln Gly Arg Gly Leu Ser Ile Ala 
        115                 120                 125             


Leu Arg His Met Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Glu Gly 
    130                 135                 140                 


Val Glu Ser Leu His Ser Pro Lys Glu Ala Ser Lys Gln Phe Lys Asp 
145                 150                 155                 160 


Leu Lys Asp Arg Val Thr Lys Val Ser Gly Val Ile Phe Asp Glu Asp 
                165                 170                 175     


Ala Thr Pro Ala Glu Val Val Cys Asp Ile Gly Leu Ser Pro Lys Gln 
            180                 185                 190         


Arg Leu Arg Ser Ala Pro Ser Ala Lys Tyr Lys Glu Gly Ala Thr Leu 
        195                 200                 205             


Ala Asp Glu Pro Val Gly Gly Lys Ser Lys Glu Gly Leu Leu Gly Gly 
    210                 215                 220                 


Lys Leu Met Gln Ser Asp Asn Ala Asn Glu Leu Arg Lys Ile Gly Ile 
225                 230                 235                 240 


Val Gln Gly Leu Ser Asn Glu Lys Val Asn Glu Ile Ile Asp Gln Val 
                245                 250                 255     


Phe Ala Ser Glu Ser Pro Lys Gly Gln Ala Gly Lys Arg Ala Lys Lys 
            260                 265                 270         


Asp Glu Leu Pro Gly Gln Glu Gln Tyr Val Arg Ala Leu Arg Ala His 
        275                 280                 285             


Leu Ala Phe Gln Arg Phe Arg Ile Val Ala Ala Val Ala Asn Leu Arg 
    290                 295                 300                 


Ile Leu Glu Ala Glu Pro Lys His Glu Arg Leu Leu Ser Gln Ser Glu 
305                 310                 315                 320 


Lys Asp Lys Val Ile Glu Phe Leu Met Ser Ala Asp Gly Asp Asp Gly 
                325                 330                 335     


Val Thr Trp Ser Asp Val Ala Glu Glu Leu Gly Ile Glu Arg Glu Cys 
            340                 345                 350         


Leu Ser Gly Thr Ala Lys Arg Gly Ala Asp Gly Glu Arg Pro Ser Ser 
        355                 360                 365             


Phe Pro Pro Thr Asn Ser Thr Asn Ile Ser Ile Val Arg Ser Lys Val 
    370                 375                 380                 


Lys Pro Leu Ile Glu Trp Trp Arg Lys Ala Ser Asp Asp Glu Gln Ala 
385                 390                 395                 400 


Thr Leu Val Thr Ala Leu Ser Asn Ala Asp Glu Leu Thr Asp Asp Gln 
                405                 410                 415     


Pro Ser Ala Glu Thr Val Arg Gln Phe Leu Ser Ser Pro Asp Glu Gln 
            420                 425                 430         


Ser Gln Glu Lys Ile Asp Lys Ile Ser Leu Pro Lys Gly Arg Ala Ala 
        435                 440                 445             


Tyr Ser Val Asn Ser Leu Glu Arg Leu Thr Arg Arg Met Leu Lys Asp 
    450                 455                 460                 


Ser Val Asp Leu Phe Glu Ala Arg Lys Arg Glu Phe Gly Val Asp Asn 
465                 470                 475                 480 


Asn Trp Thr Pro Thr Pro Asp Ser Ile Gly Glu Pro Val Gly Asn Pro 
                485                 490                 495     


Ala Val Asp Arg Val Leu Lys Ile Val Asn Arg Trp Leu Leu Ala Val 
            500                 505                 510         


Thr Arg Lys Trp Gly Pro Pro Lys Val Val Asn Ile Glu His Val Arg 
        515                 520                 525             


Val Gly Phe Thr Ser Ala Ala Gln Thr Arg Lys Tyr Glu Glu Glu Asn 
    530                 535                 540                 


Lys Thr Asn Arg Glu Arg Asn Leu Ala Ile Leu Glu Glu Leu Arg Asp 
545                 550                 555                 560 


Lys Phe Gly Thr Ser Gly Lys Ile Arg Arg Glu Asp Ile Thr Arg Phe 
                565                 570                 575     


Ala Ala Leu Arg Arg Gln Asn Cys Gln Cys Ala Tyr Cys Gly Glu Ala 
            580                 585                 590         


Ile Thr Phe Phe Asp Cys Glu Met Asp His Ile Val Pro Arg Lys Gly 
        595                 600                 605             


Pro Gly Ser Thr Asn Thr Arg Asn Asn Leu Val Ala Ile Cys Glu Arg 
    610                 615                 620                 


Cys Asn Lys Ser Lys Ser Asn Met Pro Phe Ser Leu Trp Ala Gln Asn 
625                 630                 635                 640 


Cys Asp Ile Pro Gly Val Ser Val Glu Ala Val Ile Asp Arg Val Arg 
                645                 650                 655     


Thr Trp Ile Lys Asp Pro Glu Leu Asn Pro Lys Gln Tyr Asn Asn Phe 
            660                 665                 670         


Lys Lys Asp Val Ile Glu Arg Leu Arg Lys Thr Val Asp Asp Asp Ala 
        675                 680                 685             


Ile Asp Asn Arg Ser Ile Glu Ser Val Ala Trp Met Ala Thr Glu Leu 
    690                 695                 700                 


Ala Asp Arg Ile Gly Ser His Phe Arg Thr Ala Gly Ala Asn Thr Lys 
705                 710                 715                 720 


Val Arg Val Tyr Arg Gly Trp Leu Thr Ser Glu Ala Arg Lys Ala Ser 
                725                 730                 735     


Gly Phe Glu Gly Lys Ile Asn Leu Ile Gly Gly Arg Gly Lys Thr Arg 
            740                 745                 750         


Leu Asp Arg Arg His His Ala Met Asp Ala Ala Thr Ile Ala Leu Met 
        755                 760                 765             


Arg Gln Ser Val Ala Gln Thr Leu Val Glu Arg Ala Ser Ile Arg Glu 
    770                 775                 780                 


Ser Asp Arg Leu Arg Arg Val Val Ser Ser Ser Trp Lys Asp Tyr Arg 
785                 790                 795                 800 


Gly Ala Asp Arg Asp Lys Gln Phe Ser Tyr Gly Ser Trp Leu Asn Ser 
                805                 810                 815     


Met Asn Ala Leu Ala Glu Leu Phe Asn Arg Ala Ile Asp Ala Asp Gly 
            820                 825                 830         


Ile Pro Val Thr Gln Asn Leu Arg Leu Arg Leu Gly Asn Gly Glu Ala 
        835                 840                 845             


His Asp Ala Thr Ile Arg Ser Leu Glu Lys Lys Arg Val Gly Ala Ser 
    850                 855                 860                 


Trp Thr Ile Gly Glu Ile Asp Arg Ala Ser Thr Pro Gln Leu Trp Leu 
865                 870                 875                 880 


Ala Leu Thr Arg Gln Glu Asp Phe Asp Gln Asn Asp Gly Leu Pro Ala 
                885                 890                 895     


Asn Ala Ser Arg Glu Leu Arg Val Lys Asn His Trp Phe His Ala Glu 
            900                 905                 910         


Glu Asn Val Thr Leu Phe Pro Thr Lys Ser Ala Ala Ile Ala Val Arg 
        915                 920                 925             


Gly Gly Tyr Ala Glu Ile Gly Asn Thr Ile His His Ala Arg Leu Tyr 
    930                 935                 940                 


Lys Leu Pro Gly Lys Lys Leu Thr Tyr Gly Met Ile Arg Val Phe Ala 
945                 950                 955                 960 


Ile Asp Leu Leu Cys Ala Trp His Thr Asp Leu Phe Ser Ser Pro Leu 
                965                 970                 975     


Leu Pro Glu Ser Ile Ser Leu Arg Thr Ala Glu Thr Lys Val Arg Arg 
            980                 985                 990         


Ala Val Glu Asp Gly Ala Ala Met  Tyr Ile Gly Trp Leu  Val Asp Gly 
        995                 1000                 1005             


Asp Glu  Ile Val Leu Asp Pro  Glu Thr Lys Ala Phe  Lys Ser Asn 
    1010                 1015                 1020             


Lys Ile  Gly Glu Tyr Leu Cys  Glu Phe Pro Gly Thr  Lys Arg Trp 
    1025                 1030                 1035             


Lys Val  Asp Gly Phe Pro Asp  Lys Glu Lys Leu Arg  Leu Arg Pro 
    1040                 1045                 1050             


Leu Gln  Leu Ala Gly Glu Gly  Leu Pro Glu Asp Val  Ser Ala Gly 
    1055                 1060                 1065             


Thr Glu  Glu Ile Leu Gly Pro  Lys Gly Asn Gly Trp  Arg Val Ala 
    1070                 1075                 1080             


Ile Asn  Ala Leu Phe Lys Ser  Ser Gln Leu Val Val  Val Arg Arg 
    1085                 1090                 1095             


Thr Ala  Leu Gly Met Val Arg  Lys Leu Ser Arg Arg  His Leu Pro 
    1100                 1105                 1110             


Leu Thr  Thr Arg Leu Arg Gly  
    1115                 1120 


<210> 57
<211> 1114
<212> PRT
<213> Actinomyces turicensis


<220>
<223> Actinomyces turicensis ACS-279-V-Col4

<400> 57
Met Gln Phe His Phe Tyr Met Val Tyr Val Thr Met Lys Gly Met Asn 
1               5                   10                  15      


Asp Lys Asp Ala Ser Gln Gln Leu Arg Tyr Arg Val Gly Ile Asp Val 
            20                  25                  30          


Gly Thr His Ser Ile Gly Phe Cys Ala Val Glu Val Asp Glu Ser Gly 
        35                  40                  45              


Met Pro Ile Gln Leu Leu Asn Ser Met Val His Lys His Asp Ser Gly 
    50                  55                  60                  


Ile Asp Pro Gly Gly Asn Asp Thr Ala Thr Thr Arg Leu Ala Glu Ala 
65                  70                  75                  80  


Gly Val Ala Arg Arg Thr Arg Arg Leu Ile Arg Arg Arg Lys Lys Arg 
                85                  90                  95      


Leu Gln Glu Leu Asp Ala Phe Ile Glu Glu Cys Gly Trp Pro Leu Val 
            100                 105                 110         


Asp Leu Ala Thr Ile Thr Asp Ala Arg Ser Pro Trp Arg Ile Arg Ala 
        115                 120                 125             


His Leu Ala Thr Glu His Ile Asp Asp Glu Ala Glu Gln Gly Lys Leu 
    130                 135                 140                 


Leu Ser Ile Ala Leu Arg His Met Ala Arg His Arg Gly Trp Arg Ser 
145                 150                 155                 160 


Pro Tyr Ala Arg Ile Ser Ser Leu His Ile Gln Ala Asp Pro Ser Glu 
                165                 170                 175     


Gln Leu Lys Ala Leu Ala Gln Arg Val Ser Glu Lys Thr Gly Ile Ser 
            180                 185                 190         


Leu Thr Ala Asp Gln Thr Pro Ala Gln Leu Ile Ser Val Tyr Leu Asp 
        195                 200                 205             


Val Phe Glu Thr Gly Lys Leu Arg Gly Pro Glu Gly Ile Leu Gly Gly 
    210                 215                 220                 


Lys Leu Met Gln Ser Asp Asn Ala Asn Glu Leu Arg Arg Ile Ala Thr 
225                 230                 235                 240 


Val Gln Gly Leu Asp Asn Asp Leu Leu Lys Lys Ile Ile Gly Phe Val 
                245                 250                 255     


Phe Ala Ala Glu Ser Pro Lys Gly Ser Ala Ala Lys Arg Val Gly Lys 
            260                 265                 270         


Asp Val Leu Pro Gly Ala His Gly Leu Arg Ala Glu Lys Ala His Pro 
        275                 280                 285             


Ala Phe Gln Gln Phe Arg Ile Val Ser Ile Val Gln Asn Leu Arg Ile 
    290                 295                 300                 


Lys Glu Gly Thr Gly Leu Arg Ala Leu Thr Ser Glu Glu Thr Glu Ile 
305                 310                 315                 320 


Val Val Asp Phe Leu Asn Gln Ala Gly Leu Thr Glu Ala Pro Thr Trp 
                325                 330                 335     


Glu Glu Val Ala Asp Asn Leu Glu Ile Pro Arg Ser His Leu Lys Gly 
            340                 345                 350         


Thr Ala Thr Glu Gly Phe Asp Gly Ile Ala Pro Ser Thr Arg Pro Pro 
        355                 360                 365             


Phe Asp Val Thr Ser Gln Lys Ile Leu Asn Gly Lys Leu Lys Lys Leu 
    370                 375                 380                 


Ser Ala Trp Trp Lys Asp Ala Asp Tyr Asp His Arg Cys Ala Met Val 
385                 390                 395                 400 


Asn Ala Leu Ser Asn Val Gly Ser Asp Asp Glu Gly Ser Leu Ala Asp 
                405                 410                 415     


Asp Asp Val Arg Glu Phe Leu Ser Asp Phe Thr Asp Glu Glu Leu Glu 
            420                 425                 430         


Ala Leu Asp Lys Val Glu Leu Pro Gly Gly Arg Ala Ala Tyr Ser Val 
        435                 440                 445             


Asp Ser Leu Glu Lys Leu Thr Asn Thr Met Leu Ser Glu Gly Cys Asp 
    450                 455                 460                 


Leu His Ser Ala Arg Lys Ile Ala Phe Gly Val Asp Asp Ser Trp Thr 
465                 470                 475                 480 


Pro Pro Ala Glu Pro Ile Gly Gln Pro Val Gly Asn Pro Ala Val Asp 
                485                 490                 495     


Arg Val Leu Lys Gln Val Ala Arg Trp Ile Ser Ala Ala Thr Asn Gln 
            500                 505                 510         


Trp Gly Thr Pro Glu Ser Val Asn Ile Glu His Val Arg Asp Ala Leu 
        515                 520                 525             


Gly Ser Glu Lys Ala Ser Arg Glu Tyr Gln Arg Ser Leu Gln Thr Arg 
    530                 535                 540                 


Arg Ile Arg Asn Glu Lys Leu Phe Ala Glu Met Arg Glu Arg Leu Asp 
545                 550                 555                 560 


Ile Gly Gly Lys Pro Arg Arg Ser Glu Leu Thr Arg Tyr Leu Ala Leu 
                565                 570                 575     


Gln Arg Gln Asn Cys Gln Cys Leu Tyr Cys Gly Met Pro Ile Thr Tyr 
            580                 585                 590         


Thr Asp Ala Glu Met Asp His Ile Val Pro Arg Lys Gly Ala Ala Ser 
        595                 600                 605             


Thr Asn Thr Arg Glu Asn Phe Ala Ala Val Cys Arg Ala Cys Asn His 
    610                 615                 620                 


Gln Lys Ser Asn Leu Pro Phe Ala Val Trp Ala Glu Lys Thr Glu Arg 
625                 630                 635                 640 


Pro Gly Val Ser Val Lys Glu Ala Tyr Lys Arg Val Ser Asp Met Arg 
                645                 650                 655     


Ile Glu Pro Gly Met Asn Gly Arg Gln Met Asn Glu Phe Arg Lys Ala 
            660                 665                 670         


Ile Arg Leu Arg Leu Thr Thr Lys His Ala Asp Ala Glu Ile Asp Gly 
        675                 680                 685             


Arg Ser Leu Glu Ser Val Ala Trp Met Ala Asn Glu Leu Arg His Arg 
    690                 695                 700                 


Ile Glu Gly Phe Tyr Arg Ser Ala Glu Asn Asp Val Thr Val Arg Val 
705                 710                 715                 720 


Phe Arg Gly Ala Val Thr Ala Glu Gly Arg Arg Ala Ser Gly Phe Glu 
                725                 730                 735     


Ser Arg Val Asn Leu Ile Gly Gly Lys Gly Lys Thr Arg Leu Asp Arg 
            740                 745                 750         


Arg His His Ala Met Asp Ala Leu Thr Ile Ala Leu Met Glu Pro Gly 
        755                 760                 765             


Ile Ala Gln Thr Ile Ala Leu Arg Met Asn Met Arg Glu Ser Gln Arg 
    770                 775                 780                 


Val Leu Gly Glu Gln Glu Thr Trp Lys Ser Phe Thr Gly Gly Ser Asp 
785                 790                 795                 800 


Thr Ala Arg Lys Arg Trp Glu His Trp Cys Glu Glu Met Leu Arg Ala 
                805                 810                 815     


Ser Glu Leu Phe Asn Val Phe Leu Ala Glu Asp Arg Ile Pro Ile Cys 
            820                 825                 830         


Gln Asn Lys Arg Leu Arg Leu Gly Ser Ser Ala Val His Lys Ala Ile 
        835                 840                 845             


Val Gln Pro Phe Glu Ala Ser Asp Lys Arg Ile Val Ser Asp Ala Met 
    850                 855                 860                 


Pro Val Glu Leu Ile Asp Arg Ala Ser Thr Pro Ala Leu Trp Thr Ala 
865                 870                 875                 880 


Leu Thr Arg Asp Pro Asp Phe Asp Pro Lys Glu Gly Leu Pro Ala Asn 
                885                 890                 895     


Pro Ser Arg Thr Ile Arg Leu His Asp Lys Arg Leu Gly Pro Asn Glu 
            900                 905                 910         


Thr Val Glu Phe Phe Pro Thr Ala Ala Ala Cys Leu Ala Ile Arg Gly 
        915                 920                 925             


Gly Tyr Cys Glu Ile Gly Ala Gly Ile His His Ala Arg Ile Phe Arg 
    930                 935                 940                 


Ile Ser Gly Lys Lys Thr Thr Tyr Ala Met Leu Arg Val Tyr Gln Cys 
945                 950                 955                 960 


Asp Leu Val Arg Phe Gln Lys Glu Asn Leu Leu Thr Val Glu Leu Pro 
                965                 970                 975     


Ala Asn Thr Ile Ser Val Arg Thr Ala Val Pro Lys Leu Arg Glu Ala 
            980                 985                 990         


Leu Ala His Gly Thr Ala Glu Gln  Ile Gly Trp Leu Val  Val Gly Asp 
        995                 1000                 1005             


Glu Leu  Lys Ile Asp Leu Ser  Gly Phe Thr Thr Gly  Gln Ile Glu 
    1010                 1015                 1020             


Thr Phe  Asn Glu Thr Tyr Pro  Gln Ala Thr Arg Trp  Glu Val Thr 
    1025                 1030                 1035             


Gly Phe  Pro Thr Lys Thr Gln  Leu Arg Leu Lys Pro  Leu Leu Ile 
    1040                 1045                 1050             


Ala Ser  Glu Gly Leu Ala Asp  Asp Val Pro Asp Asp  Ile Val Lys 
    1055                 1060                 1065             


Ile Val  Lys Gly Pro Gly Trp  Trp Pro Ala Ile Asp  Lys Leu Leu 
    1070                 1075                 1080             


Lys Ile  Gly Asn Val Val Leu  Tyr Arg Arg Asp Thr  His Gly Lys 
    1085                 1090                 1095             


Pro Arg  Val Val Ser His Arg  Ser Leu Pro Leu Ser  Ser Lys Leu 
    1100                 1105                 1110             


Gln 
    


<210> 58
<211> 1101
<212> PRT
<213> Akkermansia muciniphila

<400> 58
Met Ser Arg Ser Leu Thr Phe Ser Phe Asp Ile Gly Tyr Ala Ser Ile 
1               5                   10                  15      


Gly Trp Ala Val Ile Ala Ser Ala Ser His Asp Asp Ala Asp Pro Ser 
            20                  25                  30          


Val Cys Gly Cys Gly Thr Val Leu Phe Pro Lys Asp Asp Cys Gln Ala 
        35                  40                  45              


Phe Lys Arg Arg Glu Tyr Arg Arg Leu Arg Arg Asn Ile Arg Ser Arg 
    50                  55                  60                  


Arg Val Arg Ile Glu Arg Ile Gly Arg Leu Leu Val Gln Ala Gln Ile 
65                  70                  75                  80  


Ile Thr Pro Glu Met Lys Glu Thr Ser Gly His Pro Ala Pro Phe Tyr 
                85                  90                  95      


Leu Ala Ser Glu Ala Leu Lys Gly His Arg Thr Leu Ala Pro Ile Glu 
            100                 105                 110         


Leu Trp His Val Leu Arg Trp Tyr Ala His Asn Arg Gly Tyr Asp Asn 
        115                 120                 125             


Asn Ala Ser Trp Ser Asn Ser Leu Ser Glu Asp Gly Gly Asn Gly Glu 
    130                 135                 140                 


Asp Thr Glu Arg Val Lys His Ala Gln Asp Leu Met Asp Lys His Gly 
145                 150                 155                 160 


Thr Ala Thr Met Ala Glu Thr Ile Cys Arg Glu Leu Lys Leu Glu Glu 
                165                 170                 175     


Gly Lys Ala Asp Ala Pro Met Glu Val Ser Thr Pro Ala Tyr Lys Asn 
            180                 185                 190         


Leu Asn Thr Ala Phe Pro Arg Leu Ile Val Glu Lys Glu Val Arg Arg 
        195                 200                 205             


Ile Leu Glu Leu Ser Ala Pro Leu Ile Pro Gly Leu Thr Ala Glu Ile 
    210                 215                 220                 


Ile Glu Leu Ile Ala Gln His His Pro Leu Thr Thr Glu Gln Arg Gly 
225                 230                 235                 240 


Val Leu Leu Gln His Gly Ile Lys Leu Ala Arg Arg Tyr Arg Gly Ser 
                245                 250                 255     


Leu Leu Phe Gly Gln Leu Ile Pro Arg Phe Asp Asn Arg Ile Ile Ser 
            260                 265                 270         


Arg Cys Pro Val Thr Trp Ala Gln Val Tyr Glu Ala Glu Leu Lys Lys 
        275                 280                 285             


Gly Asn Ser Glu Gln Ser Ala Arg Glu Arg Ala Glu Lys Leu Ser Lys 
    290                 295                 300                 


Val Pro Thr Ala Asn Cys Pro Glu Phe Tyr Glu Tyr Arg Met Ala Arg 
305                 310                 315                 320 


Ile Leu Cys Asn Ile Arg Ala Asp Gly Glu Pro Leu Ser Ala Glu Ile 
                325                 330                 335     


Arg Arg Glu Leu Met Asn Gln Ala Arg Gln Glu Gly Lys Leu Thr Lys 
            340                 345                 350         


Ala Ser Leu Glu Lys Ala Ile Ser Ser Arg Leu Gly Lys Glu Thr Glu 
        355                 360                 365             


Thr Asn Val Ser Asn Tyr Phe Thr Leu His Pro Asp Ser Glu Glu Ala 
    370                 375                 380                 


Leu Tyr Leu Asn Pro Ala Val Glu Val Leu Gln Arg Ser Gly Ile Gly 
385                 390                 395                 400 


Gln Ile Leu Ser Pro Ser Val Tyr Arg Ile Ala Ala Asn Arg Leu Arg 
                405                 410                 415     


Arg Gly Lys Ser Val Thr Pro Asn Tyr Leu Leu Asn Leu Leu Lys Ser 
            420                 425                 430         


Arg Gly Glu Ser Gly Glu Ala Leu Glu Lys Lys Ile Glu Lys Glu Ser 
        435                 440                 445             


Lys Lys Lys Glu Ala Asp Tyr Ala Asp Thr Pro Leu Lys Pro Lys Tyr 
    450                 455                 460                 


Ala Thr Gly Arg Ala Pro Tyr Ala Arg Thr Val Leu Lys Lys Val Val 
465                 470                 475                 480 


Glu Glu Ile Leu Asp Gly Glu Asp Pro Thr Arg Pro Ala Arg Gly Glu 
                485                 490                 495     


Ala His Pro Asp Gly Glu Leu Lys Ala His Asp Gly Cys Leu Tyr Cys 
            500                 505                 510         


Leu Leu Asp Thr Asp Ser Ser Val Asn Gln His Gln Lys Glu Arg Arg 
        515                 520                 525             


Leu Asp Thr Met Thr Asn Asn His Leu Val Arg His Arg Met Leu Ile 
    530                 535                 540                 


Leu Asp Arg Leu Leu Lys Asp Leu Ile Gln Asp Phe Ala Asp Gly Gln 
545                 550                 555                 560 


Lys Asp Arg Ile Ser Arg Val Cys Val Glu Val Gly Lys Glu Leu Thr 
                565                 570                 575     


Thr Phe Ser Ala Met Asp Ser Lys Lys Ile Gln Arg Glu Leu Thr Leu 
            580                 585                 590         


Arg Gln Lys Ser His Thr Asp Ala Val Asn Arg Leu Lys Arg Lys Leu 
        595                 600                 605             


Pro Gly Lys Ala Leu Ser Ala Asn Leu Ile Arg Lys Cys Arg Ile Ala 
    610                 615                 620                 


Met Asp Met Asn Trp Thr Cys Pro Phe Thr Gly Ala Thr Tyr Gly Asp 
625                 630                 635                 640 


His Glu Leu Glu Asn Leu Glu Leu Glu His Ile Val Pro His Ser Phe 
                645                 650                 655     


Arg Gln Ser Asn Ala Leu Ser Ser Leu Val Leu Thr Trp Pro Gly Val 
            660                 665                 670         


Asn Arg Met Lys Gly Gln Arg Thr Gly Tyr Asp Phe Val Glu Gln Glu 
        675                 680                 685             


Gln Glu Asn Pro Val Pro Asp Lys Pro Asn Leu His Ile Cys Ser Leu 
    690                 695                 700                 


Asn Asn Tyr Arg Glu Leu Val Glu Lys Leu Asp Asp Lys Lys Gly His 
705                 710                 715                 720 


Glu Asp Asp Arg Arg Arg Lys Lys Lys Arg Lys Ala Leu Leu Met Val 
                725                 730                 735     


Arg Gly Leu Ser His Lys His Gln Ser Gln Asn His Glu Ala Met Lys 
            740                 745                 750         


Glu Ile Gly Met Thr Glu Gly Met Met Thr Gln Ser Ser His Leu Met 
        755                 760                 765             


Lys Leu Ala Cys Lys Ser Ile Lys Thr Ser Leu Pro Asp Ala His Ile 
    770                 775                 780                 


Asp Met Ile Pro Gly Ala Val Thr Ala Glu Val Arg Lys Ala Trp Asp 
785                 790                 795                 800 


Val Phe Gly Val Phe Lys Glu Leu Cys Pro Glu Ala Ala Asp Pro Asp 
                805                 810                 815     


Ser Gly Lys Ile Leu Lys Glu Asn Leu Arg Ser Leu Thr His Leu His 
            820                 825                 830         


His Ala Leu Asp Ala Cys Val Leu Gly Leu Ile Pro Tyr Ile Ile Pro 
        835                 840                 845             


Ala His His Asn Gly Leu Leu Arg Arg Val Leu Ala Met Arg Arg Ile 
    850                 855                 860                 


Pro Glu Lys Leu Ile Pro Gln Val Arg Pro Val Ala Asn Gln Arg His 
865                 870                 875                 880 


Tyr Val Leu Asn Asp Asp Gly Arg Met Met Leu Arg Asp Leu Ser Ala 
                885                 890                 895     


Ser Leu Lys Glu Asn Ile Arg Glu Gln Leu Met Glu Gln Arg Val Ile 
            900                 905                 910         


Gln His Val Pro Ala Asp Met Gly Gly Ala Leu Leu Lys Glu Thr Met 
        915                 920                 925             


Gln Arg Val Leu Ser Val Asp Gly Ser Gly Glu Asp Ala Met Val Ser 
    930                 935                 940                 


Leu Ser Lys Lys Lys Asp Gly Lys Lys Glu Lys Asn Gln Val Lys Ala 
945                 950                 955                 960 


Ser Lys Leu Val Gly Val Phe Pro Glu Gly Pro Ser Lys Leu Lys Ala 
                965                 970                 975     


Leu Lys Ala Ala Ile Glu Ile Asp Gly Asn Tyr Gly Val Ala Leu Asp 
            980                 985                 990         


Pro Lys Pro Val Val Ile Arg His  Ile Lys Val Phe Lys  Arg Ile Met 
        995                 1000                 1005             


Ala Leu  Lys Glu Gln Asn Gly  Gly Lys Pro Val Arg  Ile Leu Lys 
    1010                 1015                 1020             


Lys Gly  Met Leu Ile His Leu  Thr Ser Ser Lys Asp  Pro Lys His 
    1025                 1030                 1035             


Ala Gly  Val Trp Arg Ile Glu  Ser Ile Gln Asp Ser  Lys Gly Gly 
    1040                 1045                 1050             


Val Lys  Leu Asp Leu Gln Arg  Ala His Cys Ala Val  Pro Lys Asn 
    1055                 1060                 1065             


Lys Thr  His Glu Cys Asn Trp  Arg Glu Val Asp Leu  Ile Ser Leu 
    1070                 1075                 1080             


Leu Lys  Lys Tyr Gln Met Lys  Arg Tyr Pro Thr Ser  Tyr Thr Gly 
    1085                 1090                 1095             


Thr Pro  Arg 
    1100     


<210> 59
<211> 1113
<212> PRT
<213> Alcanivorax pacificus


<220>
<223> Alcanivorax pacificus W11-5

<400> 59
Met Arg Tyr Arg Val Gly Leu Asp Leu Gly Thr Ala Ser Val Gly Ala 
1               5                   10                  15      


Ala Val Phe Ser Met Asp Glu Gln Gly Asn Pro Met Glu Leu Ile Trp 
            20                  25                  30          


His Tyr Glu Arg Leu Phe Ser Glu Pro Leu Val Pro Asp Met Gly Gln 
        35                  40                  45              


Leu Lys Pro Lys Lys Ala Ala Arg Arg Leu Ala Arg Gln Gln Arg Arg 
    50                  55                  60                  


Gln Ile Asp Arg Arg Ala Ser Arg Leu Arg Arg Ile Ala Ile Val Ser 
65                  70                  75                  80  


Arg Arg Leu Gly Ile Ala Pro Gly Arg Asn Asp Ser Gly Val His Gly 
                85                  90                  95      


Asn Asp Val Pro Thr Leu Arg Ala Met Ala Val Asn Glu Arg Ile Glu 
            100                 105                 110         


Leu Gly Gln Leu Arg Ala Val Leu Leu Arg Met Gly Lys Lys Arg Gly 
        115                 120                 125             


Tyr Gly Gly Thr Phe Lys Ala Val Arg Lys Val Gly Glu Ala Gly Glu 
    130                 135                 140                 


Val Ala Ser Gly Ala Ser Arg Leu Glu Glu Glu Met Val Ala Leu Ala 
145                 150                 155                 160 


Ser Val Gln Asn Lys Asp Ser Val Thr Val Gly Glu Tyr Leu Ala Ala 
                165                 170                 175     


Arg Val Glu His Gly Leu Pro Ser Lys Leu Lys Val Ala Ala Asn Asn 
            180                 185                 190         


Glu Tyr Tyr Ala Pro Glu Tyr Ala Leu Phe Arg Gln Tyr Leu Gly Leu 
        195                 200                 205             


Pro Ala Ile Lys Gly Arg Pro Asp Cys Leu Pro Asn Met Tyr Ala Leu 
    210                 215                 220                 


Arg His Gln Ile Glu His Glu Phe Glu Arg Ile Trp Ala Thr Gln Ser 
225                 230                 235                 240 


Gln Phe His Asp Val Met Lys Asp His Gly Val Lys Glu Glu Ile Arg 
                245                 250                 255     


Asn Ala Ile Phe Phe Gln Arg Pro Leu Lys Ser Pro Ala Asp Lys Val 
            260                 265                 270         


Gly Arg Cys Ser Leu Gln Thr Asn Leu Pro Arg Ala Pro Arg Ala Gln 
        275                 280                 285             


Ile Ala Ala Gln Asn Phe Arg Ile Glu Lys Gln Met Ala Asp Leu Arg 
    290                 295                 300                 


Trp Gly Met Gly Arg Arg Ala Glu Met Leu Asn Asp His Gln Lys Ala 
305                 310                 315                 320 


Val Ile Arg Glu Leu Leu Asn Gln Gln Lys Glu Leu Ser Phe Arg Lys 
                325                 330                 335     


Ile Tyr Lys Glu Leu Glu Arg Ala Gly Cys Pro Gly Pro Glu Gly Lys 
            340                 345                 350         


Gly Leu Asn Met Asp Arg Ala Ala Leu Gly Gly Arg Asp Asp Leu Ser 
        355                 360                 365             


Gly Asn Thr Thr Leu Ala Ala Trp Arg Lys Leu Gly Leu Glu Asp Arg 
    370                 375                 380                 


Trp Gln Glu Leu Asp Glu Val Thr Gln Ile Gln Val Ile Asn Phe Leu 
385                 390                 395                 400 


Ala Asp Leu Gly Ser Pro Glu Gln Leu Asp Thr Asp Asp Trp Ser Cys 
                405                 410                 415     


Arg Phe Met Gly Lys Asn Gly Arg Pro Arg Asn Phe Ser Asp Glu Phe 
            420                 425                 430         


Val Ala Phe Met Asn Glu Leu Arg Met Thr Asp Gly Phe Asp Arg Leu 
        435                 440                 445             


Ser Lys Met Gly Phe Glu Gly Gly Arg Ser Ser Tyr Ser Ile Lys Ala 
    450                 455                 460                 


Leu Lys Ala Leu Thr Glu Trp Met Ile Ala Pro His Trp Arg Glu Thr 
465                 470                 475                 480 


Pro Glu Thr His Arg Val Asp Glu Glu Ala Ala Ile Arg Glu Cys Tyr 
                485                 490                 495     


Pro Glu Ser Leu Ala Thr Pro Ala Gln Gly Gly Arg Gln Ser Lys Leu 
            500                 505                 510         


Glu Pro Pro Pro Leu Thr Gly Asn Glu Val Val Asp Val Ala Leu Arg 
        515                 520                 525             


Gln Val Arg His Thr Ile Asn Met Met Ile Asp Asp Leu Gly Ser Val 
    530                 535                 540                 


Pro Ala Gln Ile Val Val Glu Met Ala Arg Glu Met Lys Gly Gly Val 
545                 550                 555                 560 


Thr Arg Arg Asn Asp Ile Glu Lys Gln Asn Lys Arg Phe Ala Ser Glu 
                565                 570                 575     


Arg Lys Lys Ala Ala Gln Ser Ile Glu Glu Asn Gly Lys Thr Pro Thr 
            580                 585                 590         


Pro Ala Arg Ile Leu Arg Tyr Gln Leu Trp Ile Glu Gln Gly His Gln 
        595                 600                 605             


Cys Pro Tyr Cys Glu Ser Asn Ile Ser Leu Glu Gln Ala Leu Ser Gly 
    610                 615                 620                 


Ala Tyr Thr Asn Phe Glu His Ile Leu Pro Arg Thr Leu Thr Gln Ile 
625                 630                 635                 640 


Gly Arg Lys Arg Ser Glu Leu Val Leu Ala His Arg Glu Cys Asn Asp 
                645                 650                 655     


Glu Lys Gly Asn Arg Thr Pro Tyr Gln Ala Phe Gly His Asp Asp Arg 
            660                 665                 670         


Arg Trp Arg Ile Val Glu Gln Arg Ala Asn Ala Leu Pro Lys Lys Ser 
        675                 680                 685             


Ser Arg Lys Thr Arg Leu Leu Leu Leu Lys Asp Phe Glu Gly Glu Ala 
    690                 695                 700                 


Leu Thr Asp Glu Ser Ile Asp Glu Phe Ala Asp Arg Gln Leu His Glu 
705                 710                 715                 720 


Ser Ser Trp Leu Ala Lys Val Thr Thr Gln Trp Leu Ser Ser Leu Gly 
                725                 730                 735     


Ser Asp Val Tyr Val Ser Arg Gly Ser Leu Thr Ala Glu Leu Arg Arg 
            740                 745                 750         


Arg Trp Gly Leu Asp Thr Val Ile Pro Gln Val Arg Phe Glu Ser Gly 
        755                 760                 765             


Met Pro Val Val Asp Glu Glu Gly Ala Glu Ile Thr Pro Glu Glu Phe 
    770                 775                 780                 


Glu Lys Phe Arg Leu Gln Trp Glu Gly His Arg Val Thr Arg Glu Met 
785                 790                 795                 800 


Arg Thr Asp Arg Arg Pro Asp Lys Arg Ile Asp His Arg His His Leu 
                805                 810                 815     


Val Asp Ala Ile Val Thr Ala Leu Thr Ser Arg Ser Leu Tyr Gln Gln 
            820                 825                 830         


Tyr Ala Lys Ala Trp Lys Val Ala Asp Glu Lys Gln Arg His Gly Arg 
        835                 840                 845             


Val Asp Val Lys Val Glu Leu Pro Met Pro Ile Leu Thr Ile Arg Asp 
    850                 855                 860                 


Ile Ala Leu Glu Ala Val Arg Ser Val Arg Ile Ser His Lys Pro Asp 
865                 870                 875                 880 


Arg Tyr Pro Asp Gly Arg Phe Phe Glu Ala Thr Ala Tyr Gly Ile Ala 
                885                 890                 895     


Gln Arg Leu Asp Glu Arg Ser Gly Glu Lys Val Asp Trp Leu Val Ser 
            900                 905                 910         


Arg Lys Ser Leu Thr Asp Leu Ala Pro Glu Lys Lys Ser Ile Asp Val 
        915                 920                 925             


Asp Lys Val Arg Ala Asn Ile Ser Arg Ile Val Gly Glu Ala Ile Arg 
    930                 935                 940                 


Leu His Ile Ser Asn Ile Phe Glu Lys Arg Val Ser Lys Gly Met Thr 
945                 950                 955                 960 


Pro Gln Gln Ala Leu Arg Glu Pro Ile Glu Phe Gln Gly Asn Ile Leu 
                965                 970                 975     


Arg Lys Val Arg Cys Phe Tyr Ser Lys Ala Asp Asp Cys Val Arg Ile 
            980                 985                 990         


Glu His Ser Ser Arg Arg Gly His  His Tyr Lys Met Leu  Leu Asn Asp 
        995                 1000                 1005             


Gly Phe  Ala Tyr Met Glu Val  Pro Cys Lys Glu Gly  Ile Leu Tyr 
    1010                 1015                 1020             


Gly Val  Pro Asn Leu Val Arg  Pro Ser Glu Ala Val  Gly Ile Lys 
    1025                 1030                 1035             


Arg Ala  Pro Glu Ser Gly Asp  Phe Ile Arg Phe Tyr  Lys Gly Asp 
    1040                 1045                 1050             


Thr Val  Lys Asn Ile Lys Thr  Gly Arg Val Tyr Thr  Ile Lys Gln 
    1055                 1060                 1065             


Ile Leu  Gly Asp Gly Gly Gly  Lys Leu Ile Leu Thr  Pro Val Thr 
    1070                 1075                 1080             


Glu Thr  Lys Pro Ala Asp Leu  Leu Ser Ala Lys Trp  Gly Arg Leu 
    1085                 1090                 1095             


Lys Val  Gly Gly Arg Asn Ile  His Leu Leu Arg Leu  Cys Ala Glu 
    1100                 1105                 1110             


<210> 60
<211> 1029
<212> PRT
<213> Alicycliphilus denitrificans


<220>
<223> Alicycliphilus denitrificans BC

<400> 60
Met Arg Ser Leu Arg Tyr Arg Leu Ala Leu Asp Leu Gly Ser Thr Ser 
1               5                   10                  15      


Leu Gly Trp Ala Leu Phe Arg Leu Asp Ala Cys Asn Arg Pro Thr Ala 
            20                  25                  30          


Val Ile Lys Ala Gly Val Arg Ile Phe Ser Asp Gly Arg Asn Pro Lys 
        35                  40                  45              


Asp Gly Ser Ser Leu Ala Val Thr Arg Arg Ala Ala Arg Ala Met Arg 
    50                  55                  60                  


Arg Arg Arg Asp Arg Leu Leu Lys Arg Lys Thr Arg Met Gln Ala Lys 
65                  70                  75                  80  


Leu Val Glu His Gly Phe Phe Pro Ala Asp Ala Gly Lys Arg Lys Ala 
                85                  90                  95      


Leu Glu Gln Leu Asn Pro Tyr Ala Leu Arg Ala Lys Gly Leu Gln Glu 
            100                 105                 110         


Ala Leu Leu Pro Gly Glu Phe Ala Arg Ala Leu Phe His Ile Asn Gln 
        115                 120                 125             


Arg Arg Gly Phe Lys Ser Asn Arg Lys Thr Asp Lys Lys Asp Asn Asp 
    130                 135                 140                 


Ser Gly Val Leu Lys Lys Ala Ile Gly Gln Leu Arg Gln Gln Met Ala 
145                 150                 155                 160 


Glu Gln Gly Ser Arg Thr Val Gly Glu Tyr Leu Trp Thr Arg Leu Gln 
                165                 170                 175     


Gln Gly Gln Gly Val Arg Ala Arg Tyr Arg Glu Lys Pro Tyr Thr Thr 
            180                 185                 190         


Glu Glu Gly Lys Lys Arg Ile Asp Lys Ser Tyr Asp Leu Tyr Ile Asp 
        195                 200                 205             


Arg Ala Met Ile Glu Gln Glu Phe Asp Ala Leu Trp Ala Ala Gln Ala 
    210                 215                 220                 


Ala Phe Asn Pro Thr Leu Phe His Glu Ala Ala Arg Ala Asp Leu Lys 
225                 230                 235                 240 


Asp Thr Leu Leu His Gln Arg Pro Leu Arg Pro Val Lys Pro Gly Arg 
                245                 250                 255     


Cys Thr Leu Leu Pro Glu Glu Glu Arg Ala Pro Leu Ala Leu Pro Ser 
            260                 265                 270         


Thr Gln Arg Phe Arg Ile His Gln Glu Val Asn His Leu Arg Leu Leu 
        275                 280                 285             


Asp Glu Asn Leu Arg Glu Val Ala Leu Thr Leu Ala Gln Arg Asp Ala 
    290                 295                 300                 


Val Val Thr Ala Leu Glu Thr Lys Ala Lys Leu Ser Phe Glu Gln Ile 
305                 310                 315                 320 


Arg Lys Leu Leu Lys Leu Ser Gly Ser Val Gln Phe Asn Leu Glu Asp 
                325                 330                 335     


Ala Lys Arg Thr Glu Leu Lys Gly Asn Ala Thr Ser Ala Ala Leu Ala 
            340                 345                 350         


Arg Lys Glu Leu Phe Gly Ala Ala Trp Ser Gly Phe Asp Glu Ala Leu 
        355                 360                 365             


Gln Asp Glu Ile Val Trp Gln Leu Val Thr Glu Glu Gly Glu Gly Ala 
    370                 375                 380                 


Leu Ile Ala Trp Leu Gln Thr His Thr Gly Val Asp Glu Ala Arg Ala 
385                 390                 395                 400 


Gln Ala Ile Val Asp Val Ser Leu Pro Glu Gly Tyr Gly Asn Leu Ser 
                405                 410                 415     


Arg Lys Ala Leu Ala Arg Ile Val Pro Ala Leu Arg Ala Ala Val Ile 
            420                 425                 430         


Thr Tyr Asp Lys Ala Val Gln Ala Ala Gly Phe Asp His His Ser Gln 
        435                 440                 445             


Leu Gly Phe Glu Tyr Asp Ala Ser Glu Val Glu Asp Leu Val His Pro 
    450                 455                 460                 


Glu Thr Gly Glu Ile Arg Ser Val Phe Lys Gln Leu Pro Tyr Tyr Gly 
465                 470                 475                 480 


Lys Ala Leu Gln Arg His Val Ala Phe Gly Ser Gly Lys Pro Glu Asp 
                485                 490                 495     


Pro Asp Glu Lys Arg Tyr Gly Lys Ile Ala Asn Pro Thr Val His Ile 
            500                 505                 510         


Gly Leu Asn Gln Val Arg Met Val Val Asn Ala Leu Ile Arg Arg Tyr 
        515                 520                 525             


Gly Arg Pro Thr Glu Val Val Ile Glu Leu Ala Arg Asp Leu Lys Gln 
    530                 535                 540                 


Ser Arg Glu Gln Lys Val Glu Ala Gln Arg Arg Gln Ala Asp Asn Gln 
545                 550                 555                 560 


Arg Arg Asn Ala Arg Ile Arg Arg Ser Ile Ala Glu Val Leu Gly Ile 
                565                 570                 575     


Gly Glu Glu Arg Val Arg Gly Ser Asp Ile Gln Lys Trp Ile Cys Trp 
            580                 585                 590         


Glu Glu Leu Ser Phe Asp Ala Ala Asp Arg Arg Cys Pro Tyr Ser Gly 
        595                 600                 605             


Val Gln Ile Ser Ala Ala Met Leu Leu Ser Asp Glu Val Glu Val Glu 
    610                 615                 620                 


His Ile Leu Pro Phe Ser Lys Thr Leu Asp Asp Ser Leu Asn Asn Arg 
625                 630                 635                 640 


Thr Val Ala Met Arg Gln Ala Asn Arg Ile Lys Arg Asn Arg Thr Pro 
                645                 650                 655     


Trp Asp Ala Arg Ala Glu Phe Glu Ala Gln Gly Trp Ser Tyr Glu Asp 
            660                 665                 670         


Ile Leu Gln Arg Ala Glu Arg Met Pro Leu Arg Lys Arg Tyr Arg Phe 
        675                 680                 685             


Ala Pro Asp Gly Tyr Glu Arg Trp Leu Gly Asp Asp Lys Asp Phe Leu 
    690                 695                 700                 


Ala Arg Ala Leu Asn Asp Thr Arg Tyr Leu Ser Arg Val Ala Ala Glu 
705                 710                 715                 720 


Tyr Leu Arg Leu Val Cys Pro Gly Thr Arg Val Ile Pro Gly Gln Leu 
                725                 730                 735     


Thr Ala Leu Leu Arg Gly Lys Phe Gly Leu Asn Asp Val Leu Gly Leu 
            740                 745                 750         


Asp Gly Glu Lys Asn Arg Asn Asp His Arg His His Ala Val Asp Ala 
        755                 760                 765             


Cys Val Ile Gly Val Thr Asp Gln Gly Leu Met Gln Arg Phe Ala Thr 
    770                 775                 780                 


Ala Ser Ala Gln Ala Arg Gly Asp Gly Leu Thr Arg Leu Val Asp Gly 
785                 790                 795                 800 


Met Pro Met Pro Trp Pro Thr Tyr Arg Asp His Val Glu Arg Ala Val 
                805                 810                 815     


Arg His Ile Trp Val Ser His Arg Pro Asp His Gly Phe Glu Gly Ala 
            820                 825                 830         


Met Met Glu Glu Thr Ser Tyr Gly Ile Arg Lys Asp Gly Ser Ile Lys 
        835                 840                 845             


Gln Arg Arg Lys Ala Asp Gly Ser Ala Gly Arg Glu Ile Ser Asn Leu 
    850                 855                 860                 


Ile Arg Ile His Glu Ala Thr Gln Pro Leu Arg His Gly Val Ser Ala 
865                 870                 875                 880 


Asp Gly Gln Pro Leu Ala Tyr Lys Gly Tyr Val Gly Gly Ser Asn Tyr 
                885                 890                 895     


Cys Ile Glu Ile Thr Val Asn Asp Lys Gly Lys Trp Glu Gly Glu Val 
            900                 905                 910         


Ile Ser Thr Phe Arg Ala Tyr Gly Val Val Arg Ala Gly Gly Met Gly 
        915                 920                 925             


Arg Leu Arg Asn Pro His Glu Gly Gln Asn Gly Arg Lys Leu Ile Met 
    930                 935                 940                 


Arg Leu Val Ile Gly Asp Ser Val Arg Leu Glu Val Asp Gly Ala Glu 
945                 950                 955                 960 


Arg Thr Met Arg Ile Val Lys Ile Ser Gly Ser Asn Gly Gln Ile Phe 
                965                 970                 975     


Met Ala Pro Ile His Glu Ala Asn Val Asp Ala Arg Asn Thr Asp Lys 
            980                 985                 990         


Gln Asp Ala Phe Thr Tyr Thr Ser  Lys Tyr Ala Gly Ser  Leu Gln Lys 
        995                 1000                 1005             


Ala Lys  Thr Arg Arg Val Thr  Ile Ser Pro Ile Gly  Glu Val Arg 
    1010                 1015                 1020             


Asp Pro  Gly Phe Lys Gly 
    1025                 


<210> 61
<211> 1029
<212> PRT
<213> Alicycliphilus sp.

<400> 61
Met Arg Ser Leu Arg Tyr Arg Leu Ala Leu Asp Leu Gly Ser Thr Ser 
1               5                   10                  15      


Leu Gly Trp Ala Leu Phe Arg Leu Asp Ala Cys Asn Arg Pro Thr Ala 
            20                  25                  30          


Val Ile Lys Ala Gly Val Arg Ile Phe Ser Asp Gly Arg Asn Pro Lys 
        35                  40                  45              


Asp Gly Ser Ser Leu Ala Val Thr Arg Arg Ala Ala Arg Ala Met Arg 
    50                  55                  60                  


Arg Arg Arg Asp Arg Leu Leu Lys Arg Lys Thr Arg Met Gln Ala Lys 
65                  70                  75                  80  


Leu Val Glu His Gly Phe Phe Pro Ala Asp Ala Gly Lys Arg Lys Ala 
                85                  90                  95      


Leu Glu Gln Leu Asn Pro Tyr Ala Leu Arg Ala Lys Gly Leu Gln Glu 
            100                 105                 110         


Ala Leu Leu Pro Gly Glu Phe Ala Arg Ala Leu Phe His Ile Asn Gln 
        115                 120                 125             


Arg Arg Gly Phe Lys Ser Asn Arg Lys Thr Asp Lys Lys Asp Asn Asp 
    130                 135                 140                 


Ser Gly Val Leu Lys Lys Ala Ile Gly Gln Leu Arg Gln Gln Met Ala 
145                 150                 155                 160 


Glu Gln Gly Ser Arg Thr Val Gly Glu Tyr Leu Trp Thr Arg Leu Gln 
                165                 170                 175     


Gln Gly Gln Gly Val Arg Ala Arg Tyr Arg Glu Lys Pro Tyr Thr Thr 
            180                 185                 190         


Glu Glu Gly Lys Lys Arg Ile Asp Lys Ser Tyr Asp Leu Tyr Ile Asp 
        195                 200                 205             


Arg Ala Met Ile Glu Gln Glu Phe Asp Ala Leu Trp Ala Ala Gln Ala 
    210                 215                 220                 


Ala Phe Asn Pro Thr Leu Phe His Glu Ala Ala Arg Ala Asp Leu Lys 
225                 230                 235                 240 


Asp Thr Leu Leu His Gln Arg Pro Leu Arg Pro Val Lys Pro Gly Arg 
                245                 250                 255     


Cys Thr Leu Leu Pro Glu Glu Glu Arg Ala Pro Leu Ala Leu Pro Ser 
            260                 265                 270         


Thr Gln Arg Phe Arg Ile His Gln Glu Val Asn His Leu Arg Leu Leu 
        275                 280                 285             


Asp Glu Asn Leu Arg Glu Val Ala Leu Thr Leu Ala Gln Arg Asp Ala 
    290                 295                 300                 


Val Val Thr Ala Leu Glu Thr Lys Ala Lys Leu Ser Phe Glu Gln Ile 
305                 310                 315                 320 


Arg Lys Leu Leu Lys Leu Ser Gly Ser Val Gln Phe Asn Leu Glu Asp 
                325                 330                 335     


Ala Lys Arg Thr Glu Leu Lys Gly Asn Ala Thr Ser Ala Ala Leu Ala 
            340                 345                 350         


Arg Lys Glu Leu Phe Gly Ala Ala Trp Ser Gly Phe Asp Glu Ala Leu 
        355                 360                 365             


Gln Asp Glu Ile Val Trp Gln Leu Val Thr Glu Glu Gly Glu Gly Ala 
    370                 375                 380                 


Leu Ile Ala Trp Leu Gln Thr His Thr Gly Val Asp Glu Ala Arg Ala 
385                 390                 395                 400 


Gln Ala Ile Val Asp Val Ser Leu Pro Glu Gly Tyr Gly Asn Leu Ser 
                405                 410                 415     


Arg Lys Ala Leu Ala Arg Ile Val Pro Ala Leu Arg Ala Ala Val Ile 
            420                 425                 430         


Thr Tyr Asp Lys Ala Val Gln Ala Ala Gly Phe Asp His His Ser Gln 
        435                 440                 445             


Leu Gly Phe Glu Tyr Asp Ala Ser Glu Val Glu Asp Leu Val His Pro 
    450                 455                 460                 


Glu Thr Gly Glu Ile Arg Ser Val Phe Lys Gln Leu Pro Tyr Tyr Gly 
465                 470                 475                 480 


Lys Ala Leu Gln Arg His Val Ala Phe Gly Ser Gly Lys Pro Glu Asp 
                485                 490                 495     


Pro Asp Glu Lys Arg Tyr Gly Lys Ile Ala Asn Pro Thr Val His Ile 
            500                 505                 510         


Gly Leu Asn Gln Val Arg Met Val Val Asn Ala Leu Ile Arg Arg Tyr 
        515                 520                 525             


Gly Arg Pro Thr Glu Val Val Ile Glu Leu Ala Arg Asp Leu Lys Gln 
    530                 535                 540                 


Ser Arg Glu Gln Lys Val Glu Ala Gln Arg Arg Gln Ala Asp Asn Gln 
545                 550                 555                 560 


Arg Arg Asn Ala Arg Ile Arg Arg Ser Ile Ala Glu Val Leu Gly Ile 
                565                 570                 575     


Gly Glu Glu Arg Val Arg Gly Ser Asp Ile Gln Lys Trp Ile Cys Trp 
            580                 585                 590         


Glu Glu Leu Ser Phe Asp Ala Ala Asp Arg Arg Cys Pro Tyr Ser Gly 
        595                 600                 605             


Val Gln Ile Ser Ala Ala Met Leu Leu Ser Asp Glu Val Glu Val Glu 
    610                 615                 620                 


His Ile Leu Pro Phe Ser Lys Thr Leu Asp Asp Ser Leu Asn Asn Arg 
625                 630                 635                 640 


Thr Val Ala Met Arg Gln Ala Asn Arg Ile Lys Arg Asn Arg Thr Pro 
                645                 650                 655     


Trp Asp Ala Arg Ala Glu Phe Glu Ala Gln Gly Trp Ser Tyr Glu Asp 
            660                 665                 670         


Ile Leu Gln Arg Ala Glu Arg Met Pro Leu Arg Lys Arg Tyr Arg Phe 
        675                 680                 685             


Ala Pro Asp Gly Tyr Glu Arg Trp Leu Gly Asp Asp Lys Asp Phe Leu 
    690                 695                 700                 


Ala Arg Ala Leu Asn Asp Thr Arg Tyr Leu Ser Arg Val Ala Ala Glu 
705                 710                 715                 720 


Tyr Leu Arg Leu Val Cys Pro Gly Thr Arg Val Ile Pro Gly Gln Leu 
                725                 730                 735     


Thr Ala Leu Leu Arg Gly Lys Phe Gly Leu Asn Asp Val Leu Gly Leu 
            740                 745                 750         


Asp Gly Glu Lys Asn Arg Asn Asp His Arg His His Ala Val Asp Ala 
        755                 760                 765             


Cys Val Ile Gly Val Thr Asp Gln Gly Leu Met Gln Arg Phe Ala Thr 
    770                 775                 780                 


Ala Ser Ala Gln Ala Arg Gly Asp Gly Leu Thr Arg Leu Val Asp Gly 
785                 790                 795                 800 


Met Pro Met Pro Trp Pro Thr Tyr Arg Asp His Val Glu Arg Ala Val 
                805                 810                 815     


Arg His Ile Trp Val Ser His Arg Pro Asp His Gly Phe Glu Gly Ala 
            820                 825                 830         


Met Met Glu Glu Thr Ser Tyr Gly Ile Arg Lys Asp Gly Ser Ile Lys 
        835                 840                 845             


Gln Arg Arg Lys Ala Asp Gly Ser Ala Gly Arg Glu Ile Ser Asn Leu 
    850                 855                 860                 


Ile Arg Ile His Glu Ala Thr Gln Pro Leu Arg His Gly Val Ser Ala 
865                 870                 875                 880 


Asp Gly Gln Pro Leu Ala Tyr Lys Gly Tyr Val Gly Gly Ser Asn Tyr 
                885                 890                 895     


Cys Ile Glu Ile Thr Val Asn Asp Lys Gly Lys Trp Glu Gly Glu Val 
            900                 905                 910         


Ile Ser Thr Phe Arg Ala Tyr Gly Val Val Arg Ala Gly Gly Met Gly 
        915                 920                 925             


Arg Leu Arg Asn Pro His Glu Gly Gln Asn Gly Arg Lys Leu Ile Met 
    930                 935                 940                 


Arg Leu Val Ile Gly Asp Ser Val Arg Leu Glu Val Asp Gly Ala Glu 
945                 950                 955                 960 


Arg Thr Met Arg Ile Val Lys Ile Ser Gly Ser Asn Gly Gln Ile Phe 
                965                 970                 975     


Met Ala Pro Ile His Glu Ala Asn Val Asp Ala Arg Asn Thr Asp Lys 
            980                 985                 990         


Gln Asp Ala Phe Thr Tyr Thr Ser  Lys Tyr Ala Gly Ser  Leu Gln Lys 
        995                 1000                 1005             


Ala Lys  Thr Arg Arg Val Thr  Ile Ser Pro Ile Gly  Glu Val Arg 
    1010                 1015                 1020             


Asp Pro  Gly Phe Lys Gly 
    1025                 


<210> 62
<211> 1146
<212> PRT
<213> Alicyclobacillus hesperidum


<220>
<223> Alicyclobacillus hesperidum URH17-3-68

<400> 62
Met Ala Tyr Arg Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Val Ala Leu Glu Lys Asp Glu Ser Gly Leu Lys Pro Val Arg 
            20                  25                  30          


Ile Gln Asp Leu Gly Val Arg Ile Phe Asp Lys Ala Glu Asp Ser Lys 
        35                  40                  45              


Thr Gly Ala Ser Leu Ala Leu Pro Arg Arg Glu Ala Arg Ser Ala Arg 
    50                  55                  60                  


Arg Arg Thr Arg Arg Arg Arg His Arg Leu Trp Arg Val Lys Arg Leu 
65                  70                  75                  80  


Leu Glu Gln His Gly Ile Leu Ser Met Glu Gln Ile Glu Ala Leu Tyr 
                85                  90                  95      


Ala Gln Arg Thr Ser Ser Pro Asp Val Tyr Ala Leu Arg Val Ala Gly 
            100                 105                 110         


Leu Asp Arg Cys Leu Ile Ala Glu Glu Ile Ala Arg Val Leu Ile His 
        115                 120                 125             


Ile Ala His Arg Arg Gly Phe Gln Ser Asn Arg Lys Ser Glu Ile Lys 
    130                 135                 140                 


Asp Ser Asp Ala Gly Lys Leu Leu Lys Ala Val Gln Glu Asn Glu Asn 
145                 150                 155                 160 


Leu Met Gln Ser Lys Gly Tyr Arg Thr Val Ala Glu Met Leu Val Ser 
                165                 170                 175     


Glu Ala Thr Lys Thr Asp Ala Glu Gly Lys Leu Val His Gly Lys Lys 
            180                 185                 190         


His Gly Tyr Val Ser Asn Val Arg Asn Lys Ala Gly Glu Tyr Arg His 
        195                 200                 205             


Thr Val Ser Arg Gln Ala Ile Val Asp Glu Val Arg Lys Ile Phe Ala 
    210                 215                 220                 


Ala Gln Arg Ala Leu Gly Asn Asp Val Met Ser Glu Glu Leu Glu Asp 
225                 230                 235                 240 


Ser Tyr Leu Lys Ile Leu Cys Ser Gln Arg Asn Phe Asp Asp Gly Pro 
                245                 250                 255     


Gly Gly Asp Ser Pro Tyr Gly His Gly Ser Val Ser Pro Asp Gly Val 
            260                 265                 270         


Arg Gln Ser Ile Tyr Glu Arg Met Val Gly Ser Cys Thr Phe Glu Thr 
        275                 280                 285             


Gly Glu Lys Arg Ala Pro Arg Ser Ser Tyr Ser Phe Glu Arg Phe Gln 
    290                 295                 300                 


Leu Leu Thr Lys Val Val Asn Leu Arg Ile Tyr Arg Gln Gln Glu Asp 
305                 310                 315                 320 


Gly Gly Arg Tyr Pro Cys Glu Leu Thr Gln Thr Glu Arg Ala Arg Val 
                325                 330                 335     


Ile Asp Cys Ala Tyr Glu Gln Thr Lys Ile Thr Tyr Gly Lys Leu Arg 
            340                 345                 350         


Lys Leu Leu Asp Met Lys Asp Thr Glu Ser Phe Ala Gly Leu Thr Tyr 
        355                 360                 365             


Gly Leu Asn Arg Ser Arg Asn Lys Thr Glu Asp Thr Val Phe Val Glu 
    370                 375                 380                 


Met Lys Phe Tyr His Glu Val Arg Lys Ala Leu Gln Arg Ala Gly Val 
385                 390                 395                 400 


Phe Ile Gln Asp Leu Ser Ile Glu Thr Leu Asp Gln Ile Gly Trp Ile 
                405                 410                 415     


Leu Ser Val Trp Lys Ser Asp Asp Asn Arg Arg Lys Lys Leu Ser Thr 
            420                 425                 430         


Leu Gly Leu Ser Asp Asn Val Ile Glu Glu Leu Leu Pro Leu Asn Gly 
        435                 440                 445             


Ser Lys Phe Gly His Leu Ser Leu Lys Ala Ile Arg Lys Ile Leu Pro 
    450                 455                 460                 


Phe Leu Glu Asp Gly Tyr Ser Tyr Asp Val Ala Cys Glu Leu Ala Gly 
465                 470                 475                 480 


Tyr Gln Phe Gln Gly Lys Thr Glu Tyr Val Lys Gln Arg Leu Leu Pro 
                485                 490                 495     


Pro Leu Gly Glu Gly Glu Val Thr Asn Pro Val Val Arg Arg Ala Leu 
            500                 505                 510         


Ser Gln Ala Ile Lys Val Val Asn Ala Val Ile Arg Lys His Gly Ser 
        515                 520                 525             


Pro Glu Ser Ile His Ile Glu Leu Ala Arg Glu Leu Ser Lys Asn Leu 
    530                 535                 540                 


Asp Glu Arg Arg Lys Ile Glu Lys Ala Gln Lys Glu Asn Gln Lys Asn 
545                 550                 555                 560 


Asn Glu Gln Ile Lys Asp Glu Ile Arg Glu Ile Leu Gly Ser Ala His 
                565                 570                 575     


Val Thr Gly Arg Asp Ile Val Lys Tyr Lys Leu Phe Lys Gln Gln Gln 
            580                 585                 590         


Glu Phe Cys Met Tyr Ser Gly Glu Lys Leu Asp Val Thr Arg Leu Phe 
        595                 600                 605             


Glu Pro Gly Tyr Ala Glu Val Asp His Ile Ile Pro Tyr Gly Ile Ser 
    610                 615                 620                 


Phe Asp Asp Ser Tyr Asp Asn Lys Val Leu Val Lys Thr Glu Gln Asn 
625                 630                 635                 640 


Arg Gln Lys Gly Asn Arg Thr Pro Leu Glu Tyr Leu Arg Asp Lys Pro 
                645                 650                 655     


Glu Gln Lys Ala Lys Phe Ile Ala Leu Val Glu Ser Ile Pro Leu Ser 
            660                 665                 670         


Gln Lys Lys Lys Asn His Leu Leu Met Asp Lys Arg Ala Ile Asp Leu 
        675                 680                 685             


Glu Gln Glu Gly Phe Arg Glu Arg Asn Leu Ser Asp Thr Arg Tyr Ile 
    690                 695                 700                 


Thr Arg Ala Leu Met Asn His Ile Gln Ala Trp Leu Leu Phe Asp Glu 
705                 710                 715                 720 


Thr Ala Ser Thr Arg Ser Lys Arg Val Val Cys Val Asn Gly Ala Val 
                725                 730                 735     


Thr Ala Tyr Met Arg Ala Arg Trp Gly Leu Thr Lys Asp Arg Asp Ala 
            740                 745                 750         


Gly Asp Lys His His Ala Ala Asp Ala Val Val Val Ala Cys Ile Gly 
        755                 760                 765             


Asp Ser Leu Ile Gln Arg Val Thr Lys Tyr Asp Lys Phe Lys Arg Asn 
    770                 775                 780                 


Ala Leu Ala Asp Arg Asn Arg Tyr Val Gln Gln Val Ser Lys Ser Glu 
785                 790                 795                 800 


Gly Ile Thr Gln Tyr Val Asp Lys Glu Thr Gly Glu Val Phe Thr Trp 
                805                 810                 815     


Glu Ser Phe Asp Glu Arg Lys Phe Leu Pro Asn Glu Pro Leu Glu Pro 
            820                 825                 830         


Trp Pro Phe Phe Arg Asp Glu Leu Leu Ala Arg Leu Ser Asp Asp Pro 
        835                 840                 845             


Ser Lys Asn Ile Arg Ala Ile Gly Leu Leu Thr Tyr Ser Glu Thr Glu 
    850                 855                 860                 


Gln Ile Asp Pro Ile Phe Val Ser Arg Met Pro Thr Arg Lys Val Thr 
865                 870                 875                 880 


Gly Ala Ala His Lys Glu Thr Ile Arg Ser Pro Arg Ile Val Lys Val 
                885                 890                 895     


Asp Asp Asn Lys Gly Thr Glu Ile Gln Val Val Val Ser Lys Val Ala 
            900                 905                 910         


Leu Thr Glu Leu Lys Leu Thr Lys Asp Gly Glu Ile Lys Asp Tyr Phe 
        915                 920                 925             


Arg Pro Glu Asp Asp Pro Arg Leu Tyr Asn Thr Leu Arg Glu Arg Leu 
    930                 935                 940                 


Val Gln Phe Gly Gly Asp Ala Lys Ala Ala Phe Lys Glu Pro Val Tyr 
945                 950                 955                 960 


Lys Ile Ser Lys Asp Gly Ser Val Arg Thr Pro Val Arg Lys Val Lys 
                965                 970                 975     


Ile Gln Glu Lys Leu Thr Leu Gly Val Pro Val His Gly Gly Arg Gly 
            980                 985                 990         


Ile Ala Glu Asn Gly Gly Met Val  Arg Ile Asp Val Phe  Ala Lys Gly 
        995                 1000                 1005             


Gly Lys  Tyr Tyr Phe Val Pro  Ile Tyr Val Ala Asp  Val Leu Lys 
    1010                 1015                 1020             


Arg Glu  Leu Pro Asn Arg Leu  Ala Thr Ala His Lys  Pro Tyr Ser 
    1025                 1030                 1035             


Glu Trp  Arg Val Val Asp Asp  Ser Tyr Gln Phe Lys  Phe Ser Leu 
    1040                 1045                 1050             


Tyr Pro  Asn Asp Ala Val Met  Ile Lys Pro Ser Arg  Glu Val Asp 
    1055                 1060                 1065             


Ile Thr  Tyr Lys Asp Arg Lys  Glu Pro Val Gly Cys  Arg Ile Met 
    1070                 1075                 1080             


Tyr Phe  Val Ser Ala Asn Ile  Ala Ser Ala Ser Ile  Ser Leu Arg 
    1085                 1090                 1095             


Thr His  Asp Asn Ser Gly Glu  Leu Glu Gly Leu Gly  Ile Gln Gly 
    1100                 1105                 1110             


Leu Glu  Val Phe Glu Lys Tyr  Val Val Gly Pro Leu  Gly Asp Thr 
    1115                 1120                 1125             


His Pro  Val Tyr Lys Glu Arg  Arg Met Pro Phe Arg  Val Glu Arg 
    1130                 1135                 1140             


Lys Met  Asn 
    1145     


<210> 63
<211> 1052
<212> PRT
<213> Aminomonas paucivorans


<220>
<223> Aminomonas paucivorans DSM 12260

<400> 63
Met Ile Gly Glu His Val Arg Gly Gly Cys Leu Phe Asp Asp His Trp 
1               5                   10                  15      


Thr Pro Asn Trp Gly Ala Phe Arg Leu Pro Asn Thr Val Arg Thr Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Asp Gly Ser Ser Leu Ala Glu Pro Arg 
        35                  40                  45              


Arg Gln Ala Arg Gly Leu Arg Arg Arg Leu Arg Arg Lys Thr Gln Arg 
    50                  55                  60                  


Leu Glu Asp Leu Arg Arg Leu Leu Ala Lys Glu Gly Val Leu Ser Leu 
65                  70                  75                  80  


Ser Asp Leu Glu Thr Leu Phe Arg Glu Thr Pro Ala Lys Asp Pro Tyr 
                85                  90                  95      


Gln Leu Arg Ala Glu Gly Leu Asp Arg Pro Leu Ser Phe Pro Glu Trp 
            100                 105                 110         


Val Arg Val Leu Tyr His Ile Thr Lys His Arg Gly Phe Gln Ser Asn 
        115                 120                 125             


Arg Arg Asn Pro Val Glu Asp Gly Gln Glu Arg Ser Arg Gln Glu Glu 
    130                 135                 140                 


Glu Gly Lys Leu Leu Ser Gly Val Gly Glu Asn Glu Arg Leu Leu Arg 
145                 150                 155                 160 


Glu Gly Gly Tyr Arg Thr Ala Gly Glu Met Leu Ala Arg Asp Pro Lys 
                165                 170                 175     


Phe Gln Asp His Arg Arg Asn Arg Ala Gly Asp Tyr Ser His Thr Leu 
            180                 185                 190         


Ser Arg Ser Leu Leu Leu Glu Glu Ala Arg Arg Leu Phe Gln Ser Gln 
        195                 200                 205             


Arg Thr Leu Gly Asn Pro His Ala Ser Ser Asn Leu Glu Glu Ala Phe 
    210                 215                 220                 


Leu His Leu Val Ala Phe Gln Asn Pro Phe Ala Ser Gly Glu Asp Ile 
225                 230                 235                 240 


Arg Asn Lys Ala Gly His Cys Ser Leu Glu Pro Asp Gln Ile Arg Ala 
                245                 250                 255     


Pro Arg Arg Ser Ala Ser Ala Glu Thr Phe Met Leu Leu Gln Lys Thr 
            260                 265                 270         


Gly Asn Leu Arg Leu Ile His Arg Arg Thr Gly Glu Glu Arg Pro Leu 
        275                 280                 285             


Thr Asp Lys Glu Arg Glu Gln Ile His Leu Leu Ala Trp Lys Gln Glu 
    290                 295                 300                 


Lys Val Thr His Lys Thr Leu Arg Arg His Leu Glu Ile Pro Glu Glu 
305                 310                 315                 320 


Trp Leu Phe Thr Gly Leu Pro Tyr His Arg Ser Gly Asp Lys Ala Glu 
                325                 330                 335     


Glu Lys Leu Phe Val His Leu Ala Gly Ile His Glu Ile Arg Lys Ala 
            340                 345                 350         


Leu Asp Lys Gly Pro Asp Pro Ala Val Trp Asp Thr Leu Arg Ser Arg 
        355                 360                 365             


Arg Asp Leu Leu Asp Ser Ile Ala Asp Thr Leu Thr Phe Tyr Lys Asn 
    370                 375                 380                 


Glu Asp Glu Ile Leu Pro Arg Leu Glu Ser Leu Gly Leu Ser Pro Glu 
385                 390                 395                 400 


Asn Ala Arg Ala Leu Ala Pro Leu Ser Phe Ser Gly Thr Ala His Leu 
                405                 410                 415     


Ser Leu Ser Ala Leu Gly Lys Leu Leu Pro His Leu Glu Glu Gly Lys 
            420                 425                 430         


Ser Tyr Thr Gln Ala Arg Ala Asp Ala Gly Tyr Ala Ala Pro Pro Pro 
        435                 440                 445             


Asp Arg His Pro Lys Leu Pro Pro Leu Glu Glu Ala Asp Trp Arg Asn 
    450                 455                 460                 


Pro Val Val Phe Arg Ala Leu Thr Gln Thr Arg Lys Val Val Asn Ala 
465                 470                 475                 480 


Leu Val Arg Arg Tyr Gly Pro Pro Trp Cys Ile His Leu Glu Thr Ala 
                485                 490                 495     


Arg Glu Leu Ser Gln Pro Ala Lys Val Arg Arg Arg Ile Glu Thr Glu 
            500                 505                 510         


Gln Gln Ala Asn Glu Lys Lys Lys Gln Gln Ala Glu Arg Glu Phe Leu 
        515                 520                 525             


Asp Ile Val Gly Thr Ala Pro Gly Pro Gly Asp Leu Leu Lys Met Arg 
    530                 535                 540                 


Leu Trp Arg Glu Gln Gly Gly Phe Cys Pro Tyr Cys Glu Glu Tyr Leu 
545                 550                 555                 560 


Asn Pro Thr Arg Leu Ala Glu Pro Gly Tyr Ala Glu Met Asp His Ile 
                565                 570                 575     


Leu Pro Tyr Ser Arg Ser Leu Asp Asn Gly Trp His Asn Arg Val Leu 
            580                 585                 590         


Val His Gly Lys Asp Asn Arg Asp Lys Gly Asn Arg Thr Pro Phe Glu 
        595                 600                 605             


Ala Phe Gly Gly Asp Thr Ala Arg Trp Asp Arg Leu Val Ala Trp Val 
    610                 615                 620                 


Gln Ala Ser His Leu Ser Ala Pro Lys Lys Arg Asn Leu Leu Arg Glu 
625                 630                 635                 640 


Asp Phe Gly Glu Glu Ala Glu Arg Glu Leu Lys Asp Arg Asn Leu Thr 
                645                 650                 655     


Asp Thr Arg Phe Ile Thr Lys Thr Ala Ala Thr Leu Leu Arg Asp Arg 
            660                 665                 670         


Leu Thr Phe His Pro Glu Ala Pro Lys Asp Pro Val Met Thr Leu Asn 
        675                 680                 685             


Gly Arg Leu Thr Ala Phe Leu Arg Lys Gln Trp Gly Leu His Lys Asn 
    690                 695                 700                 


Arg Lys Asn Gly Asp Leu His His Ala Leu Asp Ala Ala Val Leu Ala 
705                 710                 715                 720 


Val Ala Ser Arg Ser Phe Val Tyr Arg Leu Ser Ser His Asn Ala Ala 
                725                 730                 735     


Trp Gly Glu Leu Pro Arg Gly Arg Glu Ala Glu Asn Gly Phe Ser Leu 
            740                 745                 750         


Pro Tyr Pro Ala Phe Arg Ser Glu Val Leu Ala Arg Leu Cys Pro Thr 
        755                 760                 765             


Arg Glu Glu Ile Leu Leu Arg Leu Asp Gln Gly Gly Val Gly Tyr Asp 
    770                 775                 780                 


Glu Ala Phe Arg Asn Gly Leu Arg Pro Val Phe Val Ser Arg Ala Pro 
785                 790                 795                 800 


Ser Arg Arg Leu Arg Gly Lys Ala His Met Glu Thr Leu Arg Ser Pro 
                805                 810                 815     


Lys Trp Lys Asp His Pro Glu Gly Pro Arg Thr Ala Ser Arg Ile Pro 
            820                 825                 830         


Leu Lys Asp Leu Asn Leu Glu Lys Leu Glu Arg Met Val Gly Lys Asp 
        835                 840                 845             


Arg Asp Arg Lys Leu Tyr Glu Ala Leu Arg Glu Arg Leu Ala Ala Phe 
    850                 855                 860                 


Gly Gly Asn Gly Lys Lys Ala Phe Val Ala Pro Phe Arg Lys Pro Cys 
865                 870                 875                 880 


Arg Ser Gly Glu Gly Pro Leu Val Arg Ser Leu Arg Ile Phe Asp Ser 
                885                 890                 895     


Gly Tyr Ser Gly Val Glu Leu Arg Asp Gly Gly Glu Val Tyr Ala Val 
            900                 905                 910         


Ala Asp His Glu Ser Met Val Arg Val Asp Val Tyr Ala Lys Lys Asn 
        915                 920                 925             


Arg Phe Tyr Leu Val Pro Val Tyr Val Ala Asp Val Ala Arg Gly Ile 
    930                 935                 940                 


Val Lys Asn Arg Ala Ile Val Ala His Lys Ser Glu Glu Glu Trp Asp 
945                 950                 955                 960 


Leu Val Asp Gly Ser Phe Asp Phe Arg Phe Ser Leu Phe Pro Gly Asp 
                965                 970                 975     


Leu Val Glu Ile Glu Lys Lys Asp Gly Ala Tyr Leu Gly Tyr Tyr Lys 
            980                 985                 990         


Ser Cys His Arg Gly Asp Gly Arg  Leu Leu Leu Asp Arg  His Asp Arg 
        995                 1000                 1005             


Met Pro  Arg Glu Ser Asp Cys  Gly Thr Phe Tyr Val  Ser Thr Arg 
    1010                 1015                 1020             


Lys Asp  Val Leu Ser Met Ser  Lys Tyr Gln Val Asp  Pro Leu Gly 
    1025                 1030                 1035             


Glu Ile  Arg Leu Val Gly Ser  Glu Lys Pro Pro Phe  Val Leu 
    1040                 1045                 1050         


<210> 64
<211> 1361
<212> PRT
<213> Anaerococcus tetradius


<220>
<223> Anaerococcus tetradius ATCC 35098

<400> 64
Met Gly Asn Tyr Tyr Leu Gly Leu Asp Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Thr Asp Glu Asn Tyr Asn Ile Glu Arg Phe Lys Lys Lys 
            20                  25                  30          


Asn Met Trp Gly Ile Arg Leu Phe Asp Glu Ala Lys Thr Ala Glu Ser 
        35                  40                  45              


Arg Arg Ile His Arg Gln Ala Arg Arg Met Arg Gln Arg Lys Ile Gln 
    50                  55                  60                  


Arg Leu Asn Leu Leu Met Glu Leu Phe Asp Val Glu Ile Ser Lys Val 
65                  70                  75                  80  


Asp Glu Ser Phe Phe Ile Arg Lys Lys Glu Ser Asp Leu His Tyr Glu 
                85                  90                  95      


Asp Lys Ser Gln Asp Ser Arg Tyr Ala Leu Phe Asn Asp Lys Glu Phe 
            100                 105                 110         


Asn Asp Lys Asp Tyr His Asn Lys Tyr Pro Thr Ile Phe His Leu Ile 
        115                 120                 125             


Met Asp Leu Ile Glu Asn Asp Glu Lys Lys Asp Ile Arg Leu Leu Tyr 
    130                 135                 140                 


Leu Ala Cys His Tyr Leu Ile Lys Asn Arg Gly His Phe Ile Phe Glu 
145                 150                 155                 160 


Gly Gln Lys Phe Asp Val Asn Ser Ser Leu Asn Asn Asn Ile Asn Lys 
                165                 170                 175     


Leu Lys Ser His Leu Asp Gln Phe Tyr Asn Ile Cys Leu Asp Phe Asp 
            180                 185                 190         


Asn Asp Lys Leu Ile Glu Ile Leu Val Asn Gln Asn Leu Asn Ile Ser 
        195                 200                 205             


Glu Lys Ser Lys Lys Ile Lys Glu Leu Leu Arg Lys Thr Asn Leu Glu 
    210                 215                 220                 


Val Gly Ile Ala Asn Leu Ile Ala Gly Gly Ser Ile Lys Leu Ser Asn 
225                 230                 235                 240 


Met Phe Asp Asp Asp Glu Leu Lys Asn Leu Asp Tyr Asn Ser Leu Ser 
                245                 250                 255     


Phe Lys Asn Ser Asn Phe Asp Glu Gly Arg Glu Leu Phe Glu Glu Val 
            260                 265                 270         


Leu Glu Asp Arg Phe Glu Leu Val Glu Ile Leu Lys Asp Ile His Asp 
        275                 280                 285             


Ala Ser Val Leu Glu Thr Met Leu Ser Ser Ala Ser Ile Ser Pro Asp 
    290                 295                 300                 


Gly Gly Lys Tyr Ile Ser Ser Ser Met Ile Asn Ser Tyr Asn Lys His 
305                 310                 315                 320 


Lys Arg Asp Leu Lys Leu Leu Lys Lys Ile Ile Lys Lys Tyr Lys Lys 
                325                 330                 335     


Ser Glu Tyr Asp Asn Ile Phe Arg Asp Glu Asn Ile Lys Asn Asn Tyr 
            340                 345                 350         


Leu Ser Tyr Thr Arg Thr Gly Ile Asn Lys Asn Lys Lys Val Gln Ala 
        355                 360                 365             


Glu Asp Asn Thr Asp Ser Asp Gly Phe Tyr Lys Tyr Ile Val Lys Ile 
    370                 375                 380                 


Leu Lys Asp Ile Lys Glu Asn Asp Ser Asp Glu Asp Ile Lys Tyr Ile 
385                 390                 395                 400 


Leu Ser Glu Ile Asp Lys Lys Asn Phe Val Pro Lys Gln Arg Thr Lys 
                405                 410                 415     


Glu Asn Ser Val Ile Pro Tyr Gln Leu Arg Glu Ile Glu Leu Arg Lys 
            420                 425                 430         


Ile Ile Asp Asn Gln Ser Lys Tyr His Lys Phe Leu Asn Glu Val Asp 
        435                 440                 445             


Glu Lys Gly Ile Ser Val Lys Glu Lys Ile Ile Ser Leu Leu Thr Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Ile Gly Pro Leu Asn Pro Ser Tyr Asn Glu Glu 
465                 470                 475                 480 


Lys Asn Phe Thr Thr Ser Trp Val Lys Arg Leu Ala Lys Gly Lys Val 
                485                 490                 495     


Thr Pro Trp Asn Phe Glu Asp Met Val Asp Ile Asp Ala Ser Arg Glu 
            500                 505                 510         


Ala Phe Ile Glu Asn Lys Leu Asn Lys Cys Ser Phe Leu Leu Asp Glu 
        515                 520                 525             


Thr Val Leu Pro Lys Asp Ser Leu Leu Tyr Gln Glu Tyr Met Val Leu 
    530                 535                 540                 


Asn Glu Leu Asn Asn Leu Lys Ile Asn Gly Gln Ser Ile Asn Thr Asp 
545                 550                 555                 560 


Leu Lys Lys Ser Ile Tyr Glu Glu Leu Phe Lys Lys Tyr Lys Lys Val 
                565                 570                 575     


Thr Arg Lys Arg Leu Ile Ser Tyr Ile Lys Glu Lys Glu Asn Met Ser 
            580                 585                 590         


Gly Asp Ile Val Ile Thr Gly Ile Asp Gly Asp Phe Lys Gln Gly Leu 
        595                 600                 605             


Lys Ser Tyr Ile Ala Phe Lys Asp Ile Ile Gly Glu Lys Ile Asp Asp 
    610                 615                 620                 


Asp Ile Tyr Arg Lys Glu Val Glu Lys Ile Ile Arg Asp Ile Ser Leu 
625                 630                 635                 640 


Tyr Gly Asp Asp Lys Ser Phe Ile Gln Lys Lys Ile Lys Asn Glu Asn 
                645                 650                 655     


Lys Leu Asp Leu Ser Asp Asp Gln Ile Ser Lys Ile Ala Lys Leu Lys 
            660                 665                 670         


Phe Lys Asp Trp Gly Arg Phe Ser Lys Lys Leu Leu Val Gly Ile Lys 
        675                 680                 685             


Ala Ser Asp Lys Asn Thr Gly Glu Ile Asp Asn Ile Ile Gly Phe Met 
    690                 695                 700                 


Arg Asn Tyr Asn Tyr Asn Ile Met Gln Leu Met Ala Asn Val Phe Thr 
705                 710                 715                 720 


Phe Lys Asp Glu Ile Glu Lys Leu Asn Ser Lys Tyr Tyr Thr Asp Glu 
                725                 730                 735     


Lys Ile Asn Ile Asp Tyr Leu Asp Asp Leu Tyr Leu Ser Ser Pro Ala 
            740                 745                 750         


Lys Arg Met Leu Trp Gln Ser Phe Gln Ile Val Asp Glu Ile Lys Asn 
        755                 760                 765             


Ile Lys Asn Ser Asp Pro Lys Lys Ile Phe Ile Glu Met Ala Arg Ser 
    770                 775                 780                 


Lys Glu Asp Lys Pro Thr Arg Lys Met Ser Arg Lys Ser Arg Leu Glu 
785                 790                 795                 800 


Lys Leu Tyr Thr Asp Ser Lys Lys Gln Phe Ile Lys Leu Phe Gly Pro 
                805                 810                 815     


Asp Glu Tyr Asp Lys Leu Asn Asn Glu Ile Lys Asn Lys Ser Glu Ser 
            820                 825                 830         


Asp Phe Arg Trp Asp Asn Leu Tyr Leu Tyr Tyr Thr Gln Phe Gly Arg 
        835                 840                 845             


Cys Met Tyr Ser Leu Asp Pro Ile Asp Leu Glu Glu Leu Ser Asn Lys 
    850                 855                 860                 


Asn Leu Tyr Asp Gln Asp His Ile Tyr Pro Lys Ser Lys Ile Tyr Asp 
865                 870                 875                 880 


Asp Ser Ile Glu Asn Arg Val Leu Val Lys Lys Gln Leu Asn Leu Asp 
                885                 890                 895     


Lys Ser Asn Glu Tyr Pro Ile Pro Asp Arg Val Leu Asn Lys Asp Lys 
            900                 905                 910         


Asn Lys Leu Leu Ala Phe Trp Lys Met Leu Asn Glu Lys Glu Leu Ile 
        915                 920                 925             


Gly Asp Lys Lys Tyr Ala Arg Leu Ile Arg Lys Ser Pro Phe Thr Asp 
    930                 935                 940                 


Glu Glu Leu Gly Asp Phe Ile Ala Arg Gln Leu Val Glu Thr Arg Gln 
945                 950                 955                 960 


Ala Thr Lys Glu Thr Ala Asn Met Leu Lys Arg Leu Cys Pro Asp Ser 
                965                 970                 975     


Lys Ile Val Tyr Val Lys Ala Lys Asn Val Ser Asp Phe Arg Arg Lys 
            980                 985                 990         


Phe Asp Ile Leu Lys Cys Arg Ser  Ile Asn Asp Leu His  His Ala His 
        995                 1000                 1005             


Asp Ala  Tyr Leu Asn Ile Val  Val Gly Asn Val Phe  Asp Thr Lys 
    1010                 1015                 1020             


Phe Thr  Ser Asn Pro Leu Asn  Phe Ile Lys Asn Asn  Ser Lys Asn 
    1025                 1030                 1035             


Arg Ser  Tyr Asn Leu Glu Lys  Ile Tyr Asp Tyr Asp  Val Ile Arg 
    1040                 1045                 1050             


Asn Glu  Lys Ile Ala Trp Leu  Ala Glu Arg Lys Glu  Glu Asn Gln 
    1055                 1060                 1065             


Asp Gly  Ser Ile Ala Thr Val  Leu Lys Asn Leu Ser  Lys Asn Asp 
    1070                 1075                 1080             


Ile Arg  Val Thr Arg Arg Thr  Tyr Ile Lys Cys Glu  Asp Leu Phe 
    1085                 1090                 1095             


Asp Glu  Asn Ile Val Arg Lys  Gly Asn Gly Lys Phe  Pro Ile Lys 
    1100                 1105                 1110             


Glu Asn  Asn Asn Lys Ser Asp  Thr Asn Lys Tyr Gly  Gly Tyr Ser 
    1115                 1120                 1125             


Gly Ile  Lys Asn Ala Tyr Phe  Val Leu Leu Glu Asp  Glu Lys His 
    1130                 1135                 1140             


Asn Arg  Ile Leu Glu Ala Ile  Pro Ser Phe Ile Tyr  Lys Lys Glu 
    1145                 1150                 1155             


Lys Asn  Gly Glu Lys Gly Ser  Val Ile Asn Tyr Leu  Gln Asn Ile 
    1160                 1165                 1170             


Leu Gly  Ile Lys Ser Ala Lys  Ile Leu Arg Asp Lys  Ile Lys Ile 
    1175                 1180                 1185             


Gly Ser  Leu Leu Lys Ile Asp  Lys Phe Pro Tyr Asn  Leu Ala Gly 
    1190                 1195                 1200             


Lys Ser  Gly Asn Gly Ile Leu  Ile Ser Gly Gly Val  Gln Leu Ile 
    1205                 1210                 1215             


Leu Asp  Lys Asn Thr Ser Lys  Tyr Ile Lys Lys Ile  Glu Asn Tyr 
    1220                 1225                 1230             


Lys Tyr  Lys Leu Asp Glu Asn  Lys Asp Tyr Gln Ile  Asn Ile Phe 
    1235                 1240                 1245             


Asp Lys  Leu Ser Lys Glu Glu  Asn Ile Lys Leu Phe  Asp Leu Phe 
    1250                 1255                 1260             


Val Asp  Lys Phe Glu Asn Ser  Ile Tyr Lys Asn Arg  Val Asn Ile 
    1265                 1270                 1275             


Lys Leu  Lys Glu Ile Lys Leu  Ala Arg Pro Lys Phe  Glu His Leu 
    1280                 1285                 1290             


Ser Ile  Glu Glu Gln Ile Lys  Thr Leu Thr Gln Met  Leu Ile Leu 
    1295                 1300                 1305             


Phe Gly  Arg Glu Asn Asn Ala  Val Asn Leu Glu Tyr  Ile Gly Leu 
    1310                 1315                 1320             


Pro Lys  Asn Thr Gly Lys Thr  Lys Ile Asn Lys Lys  Ile Asn Asn 
    1325                 1330                 1335             


Lys Asp  Ile Lys Ile Ile Asn  Gln Ser Ile Thr Gly  Leu Tyr Glu 
    1340                 1345                 1350             


Thr Glu  Glu Asp Leu Ala Asn  Ile 
    1355                 1360     


<210> 65
<211> 1552
<212> PRT
<213> Anaerophaga sp.


<220>
<223> Anaerophaga sp. HS1

<400> 65
Met Phe Ser Gln Arg Asn Asn Pro Tyr Cys Glu Leu Leu Gln Asn Val 
1               5                   10                  15      


Lys Gln Leu Tyr Lys Glu Lys Phe Gly Lys Thr Asn Gln Val Asp Asn 
            20                  25                  30          


Ser Ile Ile Tyr Gly Phe Met Lys Arg Ile Leu Gly Leu Asp Leu Gly 
        35                  40                  45              


Thr Asn Ser Ile Gly Trp Ala Leu Val Glu Asn Asp Glu Asn Asp Arg 
    50                  55                  60                  


Lys Gly Lys Ile Ile Gly Met Gly Ser Arg Ile Ile Pro Met Asp Met 
65                  70                  75                  80  


Ser Glu Leu Asp Asn Phe Asn Lys Gly Ala Ser Ile Ser Lys Thr Ala 
                85                  90                  95      


Glu Arg Thr Arg Leu Arg Met Thr Arg Arg Leu Arg Glu Arg His Leu 
            100                 105                 110         


Leu Arg Arg Ala Arg Leu His Arg Ile Leu Asn Ile Met Gly Phe Leu 
        115                 120                 125             


Pro Glu His Tyr Arg Asn Ser Ile Asp Phe Ile Asp Lys Lys Gly Cys 
    130                 135                 140                 


Phe Phe Glu Gly Gln Glu Pro Lys Ile Ala Tyr Lys Pro Asp Lys Asn 
145                 150                 155                 160 


Ser Glu Gln Phe Cys Phe Leu Phe Thr Ser Ser Phe His Glu Met Leu 
                165                 170                 175     


Glu Asp Phe Arg Lys Phe Gln Pro Glu Leu Ile Gln Asn Arg Lys Lys 
            180                 185                 190         


Val Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr 
        195                 200                 205             


Gln Lys Ile Ser Lys Glu Glu Leu Ala Trp Ile Ile Leu Asn Phe Asn 
    210                 215                 220                 


Thr Lys Arg Gly Tyr Tyr His Leu Arg Gly Glu Asp Glu Asp Asn Gln 
225                 230                 235                 240 


Asp Asn Lys Lys Ile Lys Glu Phe Arg Ala Leu Lys Val Val Asn Val 
                245                 250                 255     


Thr Glu Arg Glu Gly Ala Asn Ser Ser Gly Lys Lys Trp Tyr Asp Met 
            260                 265                 270         


Glu Leu Glu Asn Gly Trp Val Tyr Ser Arg Gln Ser Asn Leu Pro Pro 
        275                 280                 285             


Asn Leu Glu Gly Lys Thr Ile Glu Leu Ile Val Ser Tyr Thr Leu Asp 
    290                 295                 300                 


Asn Asn Gly Asn Ile Lys Lys Asp Lys Asn Gly Lys Glu Lys Tyr Ser 
305                 310                 315                 320 


Leu Ser Met Pro Gly Glu Glu Asp Trp Asn Leu Val Lys Ile Lys Thr 
                325                 330                 335     


Glu Asn Asp Leu Lys Thr Ser Lys Lys Ser Val Gly Glu Tyr Ile Tyr 
            340                 345                 350         


Asp His Leu Leu Lys Asn Pro Asp Gln Lys Ile Arg Gly Lys Leu Ile 
        355                 360                 365             


Ser Thr Ile Glu Arg Lys Phe Tyr Lys Glu Glu Leu Ser Arg Ile Leu 
    370                 375                 380                 


Lys Thr Gln Met Asn Phe Tyr Glu Glu Leu Lys Asn Arg Glu Leu Tyr 
385                 390                 395                 400 


Gln Lys Cys Val Glu Glu Leu Tyr Pro Asn Asn Lys Ser His Gln Gln 
                405                 410                 415     


Thr Leu Leu Gln Lys Asp Phe Ile His Leu Ile Val Glu Asp Ile Ile 
            420                 425                 430         


Phe Tyr Gln Arg Pro Leu Lys Ser Lys Arg Ala Phe Val Asn Asn Cys 
        435                 440                 445             


Pro Leu Glu Tyr Arg Val Tyr Val Asp Lys Lys Ser Gly Glu Leu Ile 
    450                 455                 460                 


Lys Ser Gly Val Lys Cys Ile Pro Lys Ser His Pro Leu Phe Gln Glu 
465                 470                 475                 480 


Phe Arg Leu Trp Gln Tyr Val Arg Asn Leu Arg Ile Tyr Glu Arg Glu 
                485                 490                 495     


Arg Met Val Asn Gly Arg Leu Met Val Asn Val Asp Val Thr Asn Glu 
            500                 505                 510         


Leu Leu Pro Asp Glu Glu His Ile Val Arg Leu Phe Asp Leu Leu Asn 
        515                 520                 525             


Asp Arg Lys Ser Phe Lys Gln Asp Asp Val Leu Arg Phe Val Gly Ile 
    530                 535                 540                 


Lys Ser Pro Lys Asp Arg Lys Arg Tyr Ser Trp Asn Tyr Pro Glu Asp 
545                 550                 555                 560 


Lys Glu Leu Pro Gly Asn Glu Thr Arg His Leu Ile Leu Ala Trp Leu 
                565                 570                 575     


Lys Lys Val Asp Gly Val Pro Glu Asp Trp Leu Asp Pro Glu Lys Leu 
            580                 585                 590         


Lys Ala Leu Trp His Leu Leu Tyr Ser Val Thr Asp Arg Glu Glu Ile 
        595                 600                 605             


Ile Lys Gly Leu His Ser Phe Ala Lys Lys Tyr Glu Leu Pro Asp Thr 
    610                 615                 620                 


Phe Val Glu His Phe Lys Lys Ile Pro Arg Leu Glu Arg Glu Tyr Gly 
625                 630                 635                 640 


Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro Leu Met Arg Met 
                645                 650                 655     


Gly Lys Tyr Trp Lys Ala Glu Glu Ile Pro Ala Asp Leu Leu Glu Lys 
            660                 665                 670         


Ala Gln Lys Ile Ile Asp Ala Glu Ala Asp Asp Arg Ile Ser Asp Glu 
        675                 680                 685             


Val Arg Glu Lys Leu Leu His Leu Lys Asp Ile Ser Gln Leu Lys Gly 
    690                 695                 700                 


Leu Pro Leu Trp Gln Ala Ser Tyr Leu Val Tyr Gly Arg His Ser Glu 
705                 710                 715                 720 


Thr Gly Glu Val Val Lys Trp Arg Thr Ser Glu Asp Leu Glu Lys Tyr 
                725                 730                 735     


Ile Leu Gln Phe Lys Gln His Ser Leu Arg Asn Pro Val Val Glu Gln 
            740                 745                 750         


Val Ile Leu Glu Ala Leu Arg Val Val Lys Asp Ile Trp Glu His Tyr 
        755                 760                 765             


Gly Glu Gly Lys Glu Gly Phe Phe Asn Glu Ile His Val Glu Ile Gly 
    770                 775                 780                 


Arg Glu Leu Lys Asn Pro Ala Asp Lys Arg Lys Lys Ile Thr Ser Gln 
785                 790                 795                 800 


Ile Gln Glu Asn Glu Asn Thr Asn Leu Arg Ile Lys Ala Leu Leu Glu 
                805                 810                 815     


Glu Leu Phe Asn Asp Pro Ser Val Lys Asn Val Arg Pro Tyr Ser Pro 
            820                 825                 830         


Ala Gln Gln Glu Ile Leu Arg Ile Tyr Glu Asp Gly Val Leu Asn Gly 
        835                 840                 845             


Gln Lys Glu Ile Pro Asp Asp Ile Leu Lys Ile Ser Lys Met Ala Arg 
    850                 855                 860                 


Pro Ser Lys Ser Gln Leu Val Lys Tyr Lys Leu Trp Leu Glu Gln Lys 
865                 870                 875                 880 


Tyr Arg Ser Pro Tyr Thr Gly Glu Ile Ile Pro Leu Ser Gln Leu Phe 
                885                 890                 895     


Thr Ser Ala Tyr Glu Ile Glu His Ile Ile Pro Gln Ala Arg Tyr Phe 
            900                 905                 910         


Asp Asp Ser Phe Ser Asn Lys Val Ile Cys Glu Ala Glu Val Asn Arg 
        915                 920                 925             


Glu Lys Gly His Gln Leu Ala Phe Glu Phe Ile Thr Lys Arg Gly Gly 
    930                 935                 940                 


Asp Glu Ile Glu Leu Asn Phe Gly Lys Lys Val Thr Ile Leu Asn Val 
945                 950                 955                 960 


Glu Glu Tyr Gln Lys Phe Val Lys Asp His Tyr Gly Arg Ser Leu Arg 
                965                 970                 975     


Ser Leu Ser Lys Met Arg Lys Leu Leu Met Glu Asp Ile Pro Asp Asp 
            980                 985                 990         


Phe Ile Asp Arg Gln Leu Asn Asp  Ser Arg Tyr Ile Ser  Lys Val Val 
        995                 1000                 1005             


Arg Asn  Leu Leu Ser Asn Ile  Val Arg Ala Glu Asp  Glu Asn Ser 
    1010                 1015                 1020             


Leu Val  Ser Lys His Leu Ile  Thr Cys Thr Gly Gly  Val Thr Thr 
    1025                 1030                 1035             


Arg Leu  Lys His Glu Trp Gly  Leu Asn Asp Val Trp  Asn Glu Leu 
    1040                 1045                 1050             


Ile Thr  Pro Arg Phe Val Arg  Leu Asn Lys Met Gly  Lys Glu Lys 
    1055                 1060                 1065             


Phe Gly  Glu Trp Ile Asn Lys  Lys Gly Lys Gln Val  Phe Gln Ile 
    1070                 1075                 1080             


Gln Met  Pro Leu Glu Leu Gln  Lys Gly Phe Asn Lys  Lys Arg Ile 
    1085                 1090                 1095             


Asp His  Arg His His Ala Leu  Asp Ala Leu Val Val  Ala Cys Ala 
    1100                 1105                 1110             


Ser Arg  Ser His Val Asn Tyr  Leu Asn Asn Asp Ser  Ala Arg Ala 
    1115                 1120                 1125             


Asn Ala  Ser Glu Thr Arg Tyr  Asp Leu Arg Asn Lys  Leu Cys Tyr 
    1130                 1135                 1140             


Lys Asp  Lys Thr Asp Ser Asn  Gly Asn Tyr Arg Trp  Lys Phe Tyr 
    1145                 1150                 1155             


Lys Pro  Trp Glu Ser Phe Thr  Glu Glu Ala Lys Asn  Arg Leu Ala 
    1160                 1165                 1170             


Gly Thr  Val Val Ser Phe Lys  Ser Asn Arg Arg Ile  Met Thr Arg 
    1175                 1180                 1185             


Ser Ser  Asn Arg Tyr Phe Lys  Trp Val Asp Thr Ser  Glu Gly Lys 
    1190                 1195                 1200             


Lys Lys  Lys Leu Val Arg Gln  Ile Lys Gly Asp Asn  Gln Ala Ile 
    1205                 1210                 1215             


Arg Lys  Pro Leu His Lys Asp  Thr Val Leu Gly Lys  Val Ser Leu 
    1220                 1225                 1230             


Arg Lys  Glu Lys Lys Val Ser  Leu Ser Lys Ala Ile  Asp Leu Trp 
    1235                 1240                 1245             


Glu Ser  Ile Val Asp Lys Pro  Leu Lys Lys Arg Ile  Gln Ser Leu 
    1250                 1255                 1260             


Arg Glu  Gln Gly Tyr Asp Lys  Lys Leu Leu Leu Lys  Tyr Phe Lys 
    1265                 1270                 1275             


Asp Arg  Asn Asn Gln Phe Asn  Gly Gln Asp Ile Ser  Arg Val Asn 
    1280                 1285                 1290             


Ile Tyr  Phe Phe Asp Asn Asn  Leu Ala Ala Arg Arg  Val Thr Leu 
    1295                 1300                 1305             


Asp Ala  Ser Phe Asn Ser Glu  Lys Arg Ile Asp Gly  Ile Thr Asp 
    1310                 1315                 1320             


Ser Gly  Ile Lys Lys Ile Leu  Tyr Ala His Leu Gln  Asn Glu Lys 
    1325                 1330                 1335             


Tyr His  Gly Lys Lys Asp Glu  Lys Gly Asn Glu Ile  Ser Pro Tyr 
    1340                 1345                 1350             


Glu Leu  Ala Phe Ser Pro Glu  Gly Leu Glu Glu Met  Asn Ala Asn 
    1355                 1360                 1365             


Ile Lys  Lys Leu Asn Gly Gly  Lys Pro His Cys Pro  Ile Tyr Lys 
    1370                 1375                 1380             


Val Arg  Leu Ala Glu Thr Ile  Gly Glu Lys Phe Lys  Leu Gly Glu 
    1385                 1390                 1395             


Lys Gly  Asn Lys Asn Lys Lys  Tyr Val Glu Ala Ala  Lys Gly Thr 
    1400                 1405                 1410             


Asn Leu  Phe Phe Ala Val Tyr  Val Asp Glu Lys Gly  Val Arg Ser 
    1415                 1420                 1425             


Phe Glu  Thr Ile Pro Phe Ser  Val Ala Leu Glu Arg  Arg Lys Gln 
    1430                 1435                 1440             


Lys Leu  Ala Val Val Pro Glu  Glu Asn Glu Asn Lys  Glu Lys Leu 
    1445                 1450                 1455             


Leu Phe  Tyr Leu Ser Pro Asn  Asp Leu Val Tyr Val  Pro Asp Glu 
    1460                 1465                 1470             


Asp Glu  Lys Leu Ile Asp Tyr  Arg Gln Leu Ser Ile  Asn Pro Thr 
    1475                 1480                 1485             


Arg Ile  Tyr Lys Met Val Ser  Ser Ser Gly Thr Gln  Cys Phe Phe 
    1490                 1495                 1500             


Ile Pro  His Phe Val Ala Ser  Pro Ile Val Gln Thr  Met Glu Leu 
    1505                 1510                 1515             


Gly Pro  Asn Asn Lys Ser Glu  Arg Ala Trp Asp Gly  Gln Met Ile 
    1520                 1525                 1530             


Lys Asn  Val Cys Tyr Lys Leu  Ser Val Asp Arg Leu  Gly Asn Val 
    1535                 1540                 1545             


Lys Ile  Glu Lys 
    1550         


<210> 66
<211> 1515
<212> PRT
<213> Anaerophaga thermohalophila


<220>
<223> Anaerophaga thermohalophila DSM 12881

<400> 66
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Glu Ser Asp Glu Glu Gln Lys Ser Gly Lys Ile Gln Gly 
            20                  25                  30          


Ile Gly Ser Arg Ile Ile Pro Met Asp Gln Asn Glu Leu Asp Asn Phe 
        35                  40                  45              


Asn Lys Gly Asn Thr Val Ser Gln Thr Ala Glu Arg Thr Arg Leu Arg 
    50                  55                  60                  


Met Val Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu Lys Glu Ile Gly Phe Leu Pro Glu His Tyr Leu Glu 
                85                  90                  95      


Gln Ile Asp Phe Thr Glu Lys Pro Gly Gly Phe Leu Pro Gly Lys Glu 
            100                 105                 110         


Pro Lys Ile Ala Tyr Lys Pro Asp Asn Phe Lys Asp Lys Tyr Asp Phe 
        115                 120                 125             


Leu Phe Gln Asp Ser Tyr His Glu Met Leu Ser Asp Phe Gln Asp Lys 
    130                 135                 140                 


Asn Pro Glu Phe Ile Gln Lys Arg Lys Lys Val Pro Gln Asp Trp Thr 
145                 150                 155                 160 


Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Ala Lys Ile Thr Lys Glu 
                165                 170                 175     


Glu Leu Ala Trp Ile Ile Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr 
            180                 185                 190         


Gln Leu Arg Gly Glu Asp Glu Asp Val Ala Lys Asn Thr Lys Lys Glu 
        195                 200                 205             


Glu Phe His Ala Leu Lys Val Val Lys Val Lys Glu Arg Glu Asp Ser 
    210                 215                 220                 


Glu Gly Ala Ser Gly Lys Trp Tyr Asp Ile Glu Leu Glu Asn Gly Trp 
225                 230                 235                 240 


Val Tyr Pro Arg Gln Ser Asn Ile Arg Pro Asp Trp Glu Gly Lys Ile 
                245                 250                 255     


Leu Glu Leu Ile Val Thr Tyr Asn Leu Asp Lys Asp Gly Asn Ile Lys 
            260                 265                 270         


Thr Asp Lys Glu Gly Asn Glu Lys Arg Ser Phe Arg Met Pro Asn Lys 
        275                 280                 285             


Asp Asp Trp Thr Leu Arg Lys Lys Arg Thr Glu Asn Glu Ile Glu Lys 
    290                 295                 300                 


Ser Gly Lys Thr Val Gly Glu Tyr Ile Tyr Asp Asn Leu Leu Asp Ala 
305                 310                 315                 320 


Pro Asp Leu Lys Ile Arg Gly Lys Leu Val Ser Thr Ile Glu Arg Lys 
                325                 330                 335     


Tyr Tyr Arg Ser Glu Leu Glu Gln Ile Leu Thr Ala Gln Lys Lys Tyr 
            340                 345                 350         


His Pro Glu Leu Ser Asn Ser Glu Leu Phe Asn Lys Cys Ile Ser Asn 
        355                 360                 365             


Leu Tyr Pro Asn Asn Asp Ile His Arg Lys Ala Leu Leu Ser Lys Asp 
    370                 375                 380                 


Phe Val His Leu Ile Ile Asn Asp Ile Ile Phe Tyr Gln Arg Pro Leu 
385                 390                 395                 400 


Lys Ser Lys Arg Ser Thr Val Ser Asn Cys Pro Leu Glu Tyr Arg Val 
                405                 410                 415     


Tyr Val Asp Lys Val Thr Gly Glu Lys Lys Lys Val Pro Leu Lys Cys 
            420                 425                 430         


Ile Pro Lys Ser His Pro Leu Tyr Gln Glu Phe Arg Leu Trp Gln Tyr 
        435                 440                 445             


Val Lys Asn Leu Arg Leu Phe Glu Lys Glu Arg Phe Glu Asn Gly Arg 
    450                 455                 460                 


Leu Leu Thr Asn Val Asp Val Thr Glu Gln Phe Leu Pro Asp Glu Asp 
465                 470                 475                 480 


Lys Tyr Val Glu Leu Phe Glu Phe Leu Asn Gly Arg Lys Thr Phe Lys 
                485                 490                 495     


Gln Asp Asp Ile Leu Lys Phe Ala Gly Ile Lys Ser Ala Lys Asp Arg 
            500                 505                 510         


Val Lys Tyr Tyr Trp Asn Tyr Pro Gln Glu Lys Glu Tyr Pro Gly Asn 
        515                 520                 525             


Glu Thr Arg Tyr Leu Ile Glu Ser Arg Leu Lys Lys Ile Glu Asn Val 
    530                 535                 540                 


Pro Asp Glu Trp Leu Asn Tyr Glu Lys Ile Glu Glu Leu Trp His Leu 
545                 550                 555                 560 


Leu Tyr Ser Val Thr Asp Lys Val Glu Ile Glu Lys Gly Leu Gln Ser 
                565                 570                 575     


Phe Ala Ala Lys Tyr Gln Leu Pro Asp Leu Phe Val Glu Val Phe Lys 
            580                 585                 590         


Gly Phe Pro Arg Met Glu Arg Glu Tyr Gly Ala Phe Ser Lys Lys Ala 
        595                 600                 605             


Ile Lys Lys Leu Leu Pro Leu Met Arg Met Gly Lys Tyr Trp Lys Leu 
    610                 615                 620                 


Glu Asn Ile Asn Pro Asp Leu Ile Glu Lys Val Gln Lys Ile Ile Asp 
625                 630                 635                 640 


Gly Glu Ala Asp Asp Asn Ile Asn Asp Gly Ile Arg Glu Arg Phe Ser 
                645                 650                 655     


Glu Ile Asn Glu Met Ser Asp Leu Arg Gly Met Pro Leu Trp Lys Ala 
            660                 665                 670         


Ser Tyr Leu Val Tyr Gly Arg His Ser Glu Ala Ala Glu Val Ile Arg 
        675                 680                 685             


Trp Arg Thr Ser Ala Asp Leu Asp Gln Tyr Ile Lys Asp Phe Lys Gln 
    690                 695                 700                 


His Ala Leu Arg Asn Pro Ile Val Glu Gln Val Val Leu Glu Ala Leu 
705                 710                 715                 720 


Arg Val Val Lys Asp Val Trp Asn Tyr Phe Gly Glu Gly Arg Glu Lys 
                725                 730                 735     


Phe Phe Asp Glu Ile His Val Glu Ile Gly Arg Asp Leu Lys Asn Pro 
            740                 745                 750         


Ala Asp Lys Arg Gln Lys Ile Ala Asn Gln Ile Gln Glu Asn Glu Asn 
        755                 760                 765             


Thr Asn Leu Arg Ile Lys Ala Leu Leu Val Glu Leu Phe Asn Asp Pro 
    770                 775                 780                 


Glu Val Gln Asn Val Arg Pro Tyr Ser Pro Val Gln Gln Gln Leu Leu 
785                 790                 795                 800 


Lys Ile Tyr Glu Asp Gly Val Leu Asn Ala Glu Arg Asp Ile Pro Asp 
                805                 810                 815     


Asp Ile Gln Lys Ile Ser Arg Met Ala Asn Pro Thr Arg Asn Gln Leu 
            820                 825                 830         


Ile Arg Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr 
        835                 840                 845             


Gly Glu Ile Ile Pro Leu Asn Lys Leu Phe Thr Ser Glu Tyr Glu Val 
    850                 855                 860                 


Glu His Ile Ile Pro Arg Ala Arg Tyr Phe Asp Asp Ser Phe Ser Asn 
865                 870                 875                 880 


Lys Ile Ile Ser Glu Ala Glu Val Asn Arg Lys Lys Asp Arg Met Leu 
                885                 890                 895     


Ala Phe Glu Phe Ile Lys Lys Leu Gly Gly Ser Thr Ile Asp Leu Asn 
            900                 905                 910         


Tyr Gly Lys Lys Val Ser Val Leu Thr Val Glu Glu Tyr Gln Gln Phe 
        915                 920                 925             


Val Lys Asp His Tyr Gly Ile Asn Pro His Ser Arg Leu Lys Met Gln 
    930                 935                 940                 


Lys Leu Leu Met Asp Glu Ile Pro Glu Ser Phe Ile Glu Arg Gln Leu 
945                 950                 955                 960 


Asn Asp Ser Arg Tyr Ile Ser Lys Met Val Arg Asn Leu Leu Ser Asn 
                965                 970                 975     


Ile Val Arg Glu Glu Asn Glu Asn Ser Pro Val Ala Lys Gln Leu Ile 
            980                 985                 990         


Thr Cys Ser Gly Ser Ile Thr Asn  Thr Leu Lys Gln Glu  Trp Gly Leu 
        995                 1000                 1005             


Asn Asp  Val Trp Asn Thr Ile  Ile Thr Pro Arg Phe  Glu Arg Leu 
    1010                 1015                 1020             


Asn Lys  Met Gly Glu Gln Lys  Tyr Gly Glu Trp Val  Asn Lys Glu 
    1025                 1030                 1035             


Gly Lys  Pro Val Phe Gln Ile  Gln Met Pro Leu Glu  Leu Gln Lys 
    1040                 1045                 1050             


Gly Phe  Asn Lys Lys Arg Ile  Asp His Arg His His  Ala Leu Asp 
    1055                 1060                 1065             


Ala Leu  Ile Val Ala Ser Ala  Thr Arg Ser His Val  Asn Tyr Leu 
    1070                 1075                 1080             


Ser Asn  Glu Ala Ala Lys Thr  Asn Ala Lys Asp Thr  Arg Phe Asp 
    1085                 1090                 1095             


Leu Arg  Asn Arg Leu Cys Tyr  Lys Glu Lys Arg Gly  Gln Asn Arg 
    1100                 1105                 1110             


Asn Phe  Thr Trp Arg Phe Tyr  Lys Pro Trp Asn Thr  Phe Thr Glu 
    1115                 1120                 1125             


Asp Ala  Lys Asn Ala Leu Asn  Asp Ile Val Val Ser  Phe Lys Ser 
    1130                 1135                 1140             


Asn His  Arg Val Ile Asn Lys  Ser Thr Asn Arg Tyr  Phe Lys Trp 
    1145                 1150                 1155             


Glu Asn  Leu Pro Gly Gly Met  Lys Lys Lys Arg Leu  Val Arg Gln 
    1160                 1165                 1170             


Glu Lys  Gly Asp Asn Trp Ala  Ile Arg Gln Ser Leu  His Lys Asp 
    1175                 1180                 1185             


Thr Val  Leu Gly Lys Val Ser  Leu Arg Lys Val Lys  Pro Val Ser 
    1190                 1195                 1200             


Leu Ser  Val Ala Leu Asp Ser  Trp Asn Asn Ile Val  Asp Lys Ala 
    1205                 1210                 1215             


Leu Lys  Lys Lys Ile Arg Ser  Leu Lys Asp Gln Gly  Tyr Asp Lys 
    1220                 1225                 1230             


Lys Leu  Met Leu Lys Tyr Phe  Lys Asp Arg Arg Asn  Glu Tyr Asn 
    1235                 1240                 1245             


Gly Glu  Asn Ile Ser Arg Val  Asn Val Tyr Tyr Phe  Asp Glu Glu 
    1250                 1255                 1260             


Met Ala  Ala Arg Arg Val Asp  Leu Asp Thr Ser Phe  Asn Ser Glu 
    1265                 1270                 1275             


Lys Arg  Ile Glu Gly Ile Thr  Asp Ser Gly Ile Lys  Lys Ile Ile 
    1280                 1285                 1290             


Tyr Ala  His Leu Lys Asn Glu  Lys Tyr His Gly Gln  Lys Asp Asp 
    1295                 1300                 1305             


Lys Gly  Lys Asp Ile Ser Pro  Tyr Glu Leu Ala Phe  Ser Pro Glu 
    1310                 1315                 1320             


Gly Ile  Ala Glu Met Asn Ala  Asn Ile Lys Gln Leu  Asn Gly Gly 
    1325                 1330                 1335             


Lys Pro  His Cys Pro Ile Tyr  Lys Val Arg Leu Ala  Glu Pro Val 
    1340                 1345                 1350             


Gly Glu  Lys Phe Gln Leu Gly  Glu Thr Gly Asn Lys  Thr Glu Lys 
    1355                 1360                 1365             


Leu Val  Glu Val Ala Lys Gly  Thr Asn Leu Phe Phe  Gly Val Tyr 
    1370                 1375                 1380             


Ala Asn  Asp Glu Gly Val Arg  Ser Phe Ala Thr Val  Pro Phe Tyr 
    1385                 1390                 1395             


Leu Ala  Val Glu Arg Glu Lys  Gln Gly Leu Pro Ala  Val Pro Gln 
    1400                 1405                 1410             


Glu Asn  Glu Asn Gly Asp Gln  Leu Leu Phe Trp Leu  Ser Pro Asn 
    1415                 1420                 1425             


Asp Leu  Val Tyr Val Pro Ser  Glu Glu Asp Ala His  Phe Ala Asn 
    1430                 1435                 1440             


Pro Lys  Gln Ile Glu Leu Asp  Asn Ser Arg Ile Tyr  Lys Met Val 
    1445                 1450                 1455             


Ser Ser  Thr Gly Thr Gln Cys  Phe Phe Ile Pro His  Phe Val Ala 
    1460                 1465                 1470             


Thr Pro  Ile Val Gln Thr Ile  Glu Leu Gly Pro Asn  Asn Lys Ser 
    1475                 1480                 1485             


Glu Arg  Ala Trp Asp Gly Gln  Met Ile Lys Lys Val  Cys Tyr Lys 
    1490                 1495                 1500             


Leu Ser  Val Asp Arg Leu Gly  Asn Val Glu Ile Glu  
    1505                 1510                 1515 


<210> 67
<211> 1168
<212> PRT
<213> Azospirillum lipoferum

<400> 67
Met Ala Arg Pro Ala Phe Arg Ala Pro Arg Arg Glu His Val Asn Gly 
1               5                   10                  15      


Trp Thr Pro Asp Pro His Arg Ile Ser Lys Pro Phe Phe Ile Leu Val 
            20                  25                  30          


Ser Trp His Leu Leu Ser Arg Val Val Ile Asp Ser Ser Ser Gly Cys 
        35                  40                  45              


Phe Pro Gly Thr Ser Arg Asp His Thr Asp Lys Phe Ala Glu Trp Glu 
    50                  55                  60                  


Cys Ala Val Gln Pro Tyr Arg Leu Ser Phe Asp Leu Gly Thr Asn Ser 
65                  70                  75                  80  


Ile Gly Trp Gly Leu Leu Asn Leu Asp Arg Gln Gly Lys Pro Arg Glu 
                85                  90                  95      


Ile Arg Ala Leu Gly Ser Arg Ile Phe Ser Asp Gly Arg Asp Pro Gln 
            100                 105                 110         


Asp Lys Ala Ser Leu Ala Val Ala Arg Arg Leu Ala Arg Gln Met Arg 
        115                 120                 125             


Arg Arg Arg Asp Arg Tyr Leu Thr Arg Arg Thr Arg Leu Met Gly Ala 
    130                 135                 140                 


Leu Val Arg Phe Gly Leu Met Pro Ala Asp Pro Ala Ala Arg Lys Arg 
145                 150                 155                 160 


Leu Glu Val Ala Val Asp Pro Tyr Leu Ala Arg Glu Arg Ala Thr Arg 
                165                 170                 175     


Glu Arg Leu Glu Pro Phe Glu Ile Gly Arg Ala Leu Phe His Leu Asn 
            180                 185                 190         


Gln Arg Arg Gly Tyr Lys Pro Val Arg Thr Ala Thr Lys Pro Asp Glu 
        195                 200                 205             


Glu Ala Gly Lys Val Lys Glu Ala Val Glu Arg Leu Glu Ala Ala Ile 
    210                 215                 220                 


Ala Ala Ala Gly Ala Pro Thr Leu Gly Ala Trp Phe Ala Trp Arg Lys 
225                 230                 235                 240 


Thr Arg Gly Glu Thr Leu Arg Ala Arg Leu Ala Gly Lys Gly Lys Glu 
                245                 250                 255     


Ala Ala Tyr Pro Phe Tyr Pro Ala Arg Arg Met Leu Glu Ala Glu Phe 
            260                 265                 270         


Asp Thr Leu Trp Ala Glu Gln Ala Arg His His Pro Asp Leu Leu Thr 
        275                 280                 285             


Ala Glu Ala Arg Glu Ile Leu Arg His Arg Ile Phe His Gln Arg Pro 
    290                 295                 300                 


Leu Lys Pro Pro Pro Val Gly Arg Cys Thr Leu Tyr Pro Asp Asp Gly 
305                 310                 315                 320 


Arg Ala Pro Arg Ala Leu Pro Ser Ala Gln Arg Leu Arg Leu Phe Gln 
                325                 330                 335     


Glu Leu Ala Ser Leu Arg Val Ile His Leu Asp Leu Ser Glu Arg Pro 
            340                 345                 350         


Leu Thr Pro Ala Glu Arg Asp Arg Ile Val Ala Phe Val Gln Gly Arg 
        355                 360                 365             


Pro Pro Lys Ala Gly Arg Lys Pro Gly Lys Val Gln Lys Ser Val Pro 
    370                 375                 380                 


Phe Glu Lys Leu Arg Gly Leu Leu Glu Leu Pro Pro Gly Thr Gly Phe 
385                 390                 395                 400 


Ser Leu Glu Ser Asp Lys Arg Pro Glu Leu Leu Gly Asp Glu Thr Gly 
                405                 410                 415     


Ala Arg Ile Ala Pro Ala Phe Gly Pro Gly Trp Thr Ala Leu Pro Leu 
            420                 425                 430         


Glu Glu Gln Asp Ala Leu Val Glu Leu Leu Leu Thr Glu Ala Glu Pro 
        435                 440                 445             


Glu Arg Ala Ile Ala Ala Leu Thr Ala Arg Trp Ala Leu Asp Glu Ala 
    450                 455                 460                 


Thr Ala Ala Lys Leu Ala Gly Ala Thr Leu Pro Asp Phe His Gly Arg 
465                 470                 475                 480 


Tyr Gly Arg Arg Ala Val Ala Glu Leu Leu Pro Val Leu Glu Arg Glu 
                485                 490                 495     


Thr Arg Gly Asp Pro Asp Gly Arg Val Arg Pro Ile Arg Leu Asp Glu 
            500                 505                 510         


Ala Val Lys Leu Leu Arg Gly Gly Lys Asp His Ser Asp Phe Ser Arg 
        515                 520                 525             


Glu Gly Ala Leu Leu Asp Ala Leu Pro Tyr Tyr Gly Ala Val Leu Glu 
    530                 535                 540                 


Arg His Val Ala Phe Gly Thr Gly Asn Pro Ala Asp Pro Glu Glu Lys 
545                 550                 555                 560 


Arg Val Gly Arg Val Ala Asn Pro Thr Val His Ile Ala Leu Asn Gln 
                565                 570                 575     


Leu Arg His Leu Val Asn Ala Ile Leu Ala Arg His Gly Arg Pro Glu 
            580                 585                 590         


Glu Ile Val Ile Glu Leu Ala Arg Asp Leu Lys Arg Ser Ala Glu Asp 
        595                 600                 605             


Arg Arg Arg Glu Asp Lys Arg Gln Ala Asp Asn Gln Lys Arg Asn Glu 
    610                 615                 620                 


Glu Arg Lys Arg Leu Ile Leu Ser Leu Gly Glu Arg Pro Thr Pro Arg 
625                 630                 635                 640 


Asn Leu Leu Lys Leu Arg Leu Trp Glu Glu Gln Gly Pro Val Glu Asn 
                645                 650                 655     


Arg Arg Cys Pro Tyr Ser Gly Glu Thr Ile Ser Met Arg Met Leu Leu 
            660                 665                 670         


Ser Glu Gln Val Asp Ile Asp His Ile Leu Pro Phe Ser Val Ser Leu 
        675                 680                 685             


Asp Asp Ser Ala Ala Asn Lys Val Val Cys Leu Arg Glu Ala Asn Arg 
    690                 695                 700                 


Ile Lys Arg Asn Arg Ser Pro Trp Glu Ala Phe Gly His Asp Ser Glu 
705                 710                 715                 720 


Arg Trp Ala Gly Ile Leu Ala Arg Ala Glu Ala Leu Pro Lys Asn Lys 
                725                 730                 735     


Arg Trp Arg Phe Ala Pro Asp Ala Leu Glu Lys Leu Glu Gly Glu Gly 
            740                 745                 750         


Gly Leu Arg Ala Arg His Leu Asn Asp Thr Arg His Leu Ser Arg Leu 
        755                 760                 765             


Ala Val Glu Tyr Leu Arg Cys Val Cys Pro Lys Val Arg Val Ser Pro 
    770                 775                 780                 


Gly Arg Leu Thr Ala Leu Leu Arg Arg Arg Trp Gly Ile Asp Ala Ile 
785                 790                 795                 800 


Leu Ala Glu Ala Asp Gly Pro Pro Pro Glu Val Pro Ala Glu Thr Leu 
                805                 810                 815     


Asp Pro Ser Pro Ala Glu Lys Asn Arg Ala Asp His Arg His His Ala 
            820                 825                 830         


Leu Asp Ala Val Val Ile Gly Cys Ile Asp Arg Ser Met Val Gln Arg 
        835                 840                 845             


Val Gln Leu Ala Ala Ala Ser Ala Glu Arg Glu Ala Ala Ala Arg Glu 
    850                 855                 860                 


Asp Asn Ile Arg Arg Val Leu Glu Gly Phe Lys Glu Glu Pro Trp Asp 
865                 870                 875                 880 


Gly Phe Arg Ala Glu Leu Glu Arg Arg Ala Arg Thr Ile Val Val Ser 
                885                 890                 895     


His Arg Pro Glu His Gly Ile Gly Gly Ala Leu His Lys Glu Thr Ala 
            900                 905                 910         


Tyr Gly Pro Val Asp Pro Pro Glu Glu Gly Phe Asn Leu Val Val Arg 
        915                 920                 925             


Lys Pro Ile Asp Gly Leu Ser Lys Asp Glu Ile Asn Ser Val Arg Asp 
    930                 935                 940                 


Pro Arg Leu Arg Arg Ala Leu Ile Asp Arg Leu Ala Ile Arg Arg Arg 
945                 950                 955                 960 


Asp Ala Asn Asp Pro Ala Thr Ala Leu Ala Lys Ala Ala Glu Asp Leu 
                965                 970                 975     


Ala Ala Gln Pro Ala Ser Arg Gly Ile Arg Arg Val Arg Val Leu Lys 
            980                 985                 990         


Lys Glu Ser Asn Pro Ile Arg Val  Glu His Gly Gly Asn  Pro Ser Gly 
        995                 1000                 1005             


Pro Arg  Ser Gly Gly Pro Phe  His Lys Leu Leu Leu  Ala Gly Glu 
    1010                 1015                 1020             


Val His  His Val Asp Val Ala  Leu Arg Ala Asp Gly  Arg Arg Trp 
    1025                 1030                 1035             


Val Gly  His Trp Val Thr Leu  Phe Glu Ala His Gly  Gly Arg Gly 
    1040                 1045                 1050             


Ala Asp  Gly Ala Ala Ala Pro  Pro Arg Leu Gly Asp  Gly Glu Arg 
    1055                 1060                 1065             


Phe Leu  Met Arg Leu His Lys  Gly Asp Cys Leu Lys  Leu Glu His 
    1070                 1075                 1080             


Lys Gly  Arg Val Arg Val Met  Gln Val Val Lys Leu  Glu Pro Ser 
    1085                 1090                 1095             


Ser Asn  Ser Val Val Val Val  Glu Pro His Gln Val  Lys Thr Asp 
    1100                 1105                 1110             


Arg Ser  Lys His Val Lys Ile  Ser Cys Asp Gln Leu  Arg Ala Arg 
    1115                 1120                 1125             


Gly Ala  Arg Arg Val Thr Val  Asp Pro Leu Gly Arg  Val Arg Val 
    1130                 1135                 1140             


His Ala  Pro Gly Ala Arg Val  Gly Ile Gly Gly Asp  Ala Gly Arg 
    1145                 1150                 1155             


Thr Ala  Met Glu Pro Ala Glu  Asp Ile Ser 
    1160                 1165             


<210> 68
<211> 1068
<212> PRT
<213> Bacillus cereus


<220>
<223> Bacillus cereus BAG4X12-1

<400> 68
Met Arg Tyr Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Cys Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Gln Glu Lys Glu Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Ile Phe Asp Lys Ala Glu Asn Pro Lys Asp Gly Lys Ser Leu Ala Ala 
        35                  40                  45              


Pro Arg Arg Asp Ala Arg Ser Thr Arg Arg Thr Leu Arg Arg Lys Lys 
    50                  55                  60                  


His Arg Met Gln Arg Ile Lys Ile Leu Leu Val Lys Gln Gly Leu Leu 
65                  70                  75                  80  


Phe Lys Thr Glu Leu Asn His Leu Tyr Glu Ser Ala Thr Glu Phe Asp 
                85                  90                  95      


Val Trp Asn Leu Arg Leu Asp Ala Leu Glu Arg Lys Leu His Pro Lys 
            100                 105                 110         


Glu Phe Ala Arg Val Leu Ile His Leu Ala Lys Arg Arg Gly Phe Lys 
        115                 120                 125             


Ser Asn Arg Lys Glu Thr Thr Leu Ser Glu Asn Gly Gln Ile Leu Glu 
    130                 135                 140                 


Ser Ile Ser Glu Asn Gln Gln Ile Met Glu Gln Gln Asn Tyr Arg Thr 
145                 150                 155                 160 


Val Gly Glu Met Ile Leu Lys Asp Lys Lys Phe Glu Asn His Lys Arg 
                165                 170                 175     


Asn Lys Asp Gly Thr Tyr Ile Gly Thr Val Thr Arg Gln Gln Leu Gln 
            180                 185                 190         


Asp Glu Ile Gln Met Ile Phe His Thr Gln Arg Leu Tyr Lys Asn Asp 
        195                 200                 205             


Tyr Ala Thr Glu Glu Phe Glu Ser Ser Tyr Leu Glu Ile Trp Ala Ser 
    210                 215                 220                 


Gln Arg Pro Tyr Ala Ser Lys Asp Gln Ile Glu Lys Met Ile Gly Tyr 
225                 230                 235                 240 


Cys Thr Leu Glu Pro Lys Glu Lys Arg Thr Pro Lys Ala Ser Trp Ser 
                245                 250                 255     


Phe Gln Tyr Phe Val Ala Leu Gln Thr Ile Asn Asn Leu Arg Leu Ile 
            260                 265                 270         


Ser Lys Asp Lys Ile Glu Glu Leu Ser Phe Glu Glu Lys Lys Gln Ile 
        275                 280                 285             


Met Asn Leu Ala Leu Glu Lys Pro Ile Val Lys Tyr Ile Asp Ile Arg 
    290                 295                 300                 


Lys Leu Leu Ser Ile Pro Asn Asp Phe Gln Phe Asn Ser Leu Ser Tyr 
305                 310                 315                 320 


Ser Ala Asp Thr Val Asp Thr Thr Leu Glu Asn Lys Arg Cys Ile Glu 
                325                 330                 335     


Leu Lys Glu Tyr His Ser Ile Asn Lys Val Tyr Lys Gln Val Tyr Gly 
            340                 345                 350         


Lys Asn Thr Pro Asn Leu Leu Pro Ile Asp Tyr Asp Thr Ile Ala Tyr 
        355                 360                 365             


Gly Leu Thr Ile Phe Lys Asp Asp Lys Asp Ile Leu Glu Tyr Leu Gln 
    370                 375                 380                 


Asn Lys Tyr Val Asn Ala Lys Gly Lys Pro Ile Lys Asn Leu Ala Lys 
385                 390                 395                 400 


Lys Thr Tyr Asp Asp Thr Phe Ile Gln Ala Leu Leu Asn Leu Asn Phe 
                405                 410                 415     


Thr Lys Met Gly His Leu Ser Phe Lys Ala Leu Lys Asn Ile Ile Pro 
            420                 425                 430         


Phe Leu Glu Glu Gly Leu Ser Tyr Asp Lys Ala Cys Glu Lys Ala Gly 
        435                 440                 445             


Tyr Asn Phe Lys Gly Thr Ser Tyr Thr Glu Arg Thr Lys Tyr Leu Pro 
    450                 455                 460                 


Val Ile Pro Gln Asn Thr Asn Pro Val Val His Arg Ala Leu Ser Gln 
465                 470                 475                 480 


Thr Arg Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Asn 
                485                 490                 495     


Ala Ile His Ile Glu Thr Ala Arg Glu Leu Ser Lys Thr Phe Gln Glu 
            500                 505                 510         


Arg Lys Glu Ile Asp Ser Arg Tyr Gln Asp Asn Ser Lys Lys Asn Glu 
        515                 520                 525             


His Ala Ile His Lys Leu Lys Glu Leu Gly Asn Ile Asn Pro Ser Gly 
    530                 535                 540                 


Ile Asn Ile Val Lys Phe Lys Leu Trp Ser Glu Gln Asp Gly Arg Cys 
545                 550                 555                 560 


Met Tyr Ser Gly Lys Tyr Ile Glu Pro His Arg Leu Phe Glu Glu Gly 
                565                 570                 575     


Tyr Thr Glu Val Asp His Ile Leu Pro Tyr Ser Arg Ser Leu Asp Asp 
            580                 585                 590         


Ser Tyr Asn Asn Lys Ile Leu Thr Leu Gly Thr Glu Asn Gln Arg Lys 
        595                 600                 605             


Gly Asn Lys Thr Pro Tyr Glu Tyr Met Gly Asn Thr Ser Ile Trp Asp 
    610                 615                 620                 


Glu Phe Glu Thr Arg Val Gln Ser Asn Lys Lys Ile Asn Phe Lys Lys 
625                 630                 635                 640 


Gln Gln Lys Leu Leu Leu Gln Asn Phe Ser Tyr Ala Arg Glu Gln Glu 
                645                 650                 655     


Phe Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Tyr Leu 
            660                 665                 670         


Thr Ser Leu Ile Gln Gln His Leu Ile Phe Ser Glu Ser Ser Ser Lys 
        675                 680                 685             


Lys Lys Val Arg Thr Val Ser Gly Ile Ile Thr Ser His Leu Arg Ser 
    690                 695                 700                 


Arg Trp Gly Phe Asn Lys Asp Arg Lys Glu Gly His Ile His His Ala 
705                 710                 715                 720 


Leu Asp Ala Val Ile Val Ala Val Thr Ser Asn His Met Ile Gln Arg 
                725                 730                 735     


Val Thr Lys Tyr Tyr Lys Leu Lys Glu Leu Asn Lys Asn Leu Gln Ala 
            740                 745                 750         


Lys Gln Leu Pro Phe Pro Glu Pro Trp Glu Gly Phe Arg Leu Glu Leu 
        755                 760                 765             


Glu Ala Arg Ile Ser Pro Asn Thr Gln Gln Tyr Leu Lys Gly Ile His 
    770                 775                 780                 


Phe Lys Asn Tyr Ala Asp Val Asn Leu Ser Asp Ile Lys Pro Ile Phe 
785                 790                 795                 800 


Val Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Glu Leu His Gln Glu 
                805                 810                 815     


Thr Ile Arg Lys Phe Leu Gly Tyr Asn Glu Lys Gly Lys Val Leu Thr 
            820                 825                 830         


Ala Ile Lys Thr Lys Leu Glu Asp Ile Pro Phe Asp Ala Asn Gly Asp 
        835                 840                 845             


Phe Pro Met Tyr Gly Lys Glu Thr Asp Leu Tyr Thr Tyr Asn Ala Ile 
    850                 855                 860                 


Lys Glu Arg Tyr Leu Ser His Glu Lys Asp Lys Arg Lys Ser Phe Gln 
865                 870                 875                 880 


Glu Pro Leu Tyr Lys Pro Thr Lys Ser Gly Glu Ile Gly Pro Leu Ile 
                885                 890                 895     


Lys Ser Ile Lys Ile Met Asp Thr Arg Thr Ile Val Asn Pro Val Asn 
            900                 905                 910         


Gln Gly Lys Gly Val Val Tyr Asn Ser Lys Ile Ala Arg Thr Asp Val 
        915                 920                 925             


Phe Lys Lys Glu Asp Lys Tyr Tyr Leu Ile Pro Ile Tyr Thr Ile Asp 
    930                 935                 940                 


Leu Leu Lys Asn Ile Leu Pro His Lys Ala Ile Thr Ala Gly Lys Gly 
945                 950                 955                 960 


Tyr Glu Asp Trp Thr Thr Ile Asp Ser Ser Phe Thr Phe Leu Phe Ser 
                965                 970                 975     


Leu Phe Pro Asn Asp Leu Ile Gln Ile Val Pro Ser Lys Asn Lys Thr 
            980                 985                 990         


Ile Lys Ala Arg Thr Thr Val Ser  Lys Lys Glu Ile Leu  Leu Pro Ser 
        995                 1000                 1005             


Leu Thr  Gly Tyr Phe Lys Gly  Val His Ser Gly Thr  Ala Gly Ile 
    1010                 1015                 1020             


Thr Val  Glu Thr His Asp Gly  Ser Val Ile Ala Asn  Val Gly Ser 
    1025                 1030                 1035             


Lys Gln  Leu Leu Leu Phe Glu  Lys Tyr Gln Val Asp  Val Leu Gly 
    1040                 1045                 1050             


His Tyr  Thr Lys Ile Lys Glu  Glu Lys Arg Met Gly  Met Ala Ile 
    1055                 1060                 1065             


<210> 69
<211> 1078
<212> PRT
<213> Bacillus cereus


<220>
<223> Bacillus cereus BAG4X2-1

<400> 69
Met Arg Tyr Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Cys Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Gln Glu Lys Glu Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Ile Phe Asp Lys Ala Glu Asn Pro Lys Asp Gly Lys Ser Leu Ala Ala 
        35                  40                  45              


Pro Arg Arg Asp Ala Arg Ser Thr Arg Arg Thr Leu Arg Arg Lys Lys 
    50                  55                  60                  


His Arg Met Gln Arg Ile Lys Val Leu Leu Val Lys His Gly Leu Leu 
65                  70                  75                  80  


Ser Lys Thr Glu Leu Asp His Leu Tyr Glu Ser Ala Thr Glu Val Asp 
                85                  90                  95      


Val Trp Asn Leu Arg Leu Asp Ala Leu Glu Arg Lys Leu Tyr Pro Lys 
            100                 105                 110         


Glu Phe Ala Arg Ile Leu Ile His Leu Ala Lys Arg Arg Gly Phe Lys 
        115                 120                 125             


Ser Asn Arg Lys Glu Thr Thr Leu Ser Glu Asn Gly Gln Ile Leu Glu 
    130                 135                 140                 


Ser Ile Ser Glu Asn Gln Gln Ile Met Glu Lys Gln Asn Tyr Arg Thr 
145                 150                 155                 160 


Val Gly Glu Met Ile Leu Lys Asp Lys Lys Phe Glu Asn His Lys Arg 
                165                 170                 175     


Asn Lys Asn Gly Thr Tyr Val Gly Thr Val Thr Arg Gln Gln Leu Gln 
            180                 185                 190         


Asp Glu Ile Gln Met Ile Phe His Ala Gln Arg Leu Tyr Lys Asn Asp 
        195                 200                 205             


Tyr Ala Thr Glu Glu Phe Glu Ser Ser Tyr Leu Glu Ile Trp Ala Ser 
    210                 215                 220                 


Gln Arg Pro Tyr Ala Ser Lys Asp Gln Ile Glu Lys Met Ile Gly Tyr 
225                 230                 235                 240 


Cys Thr Leu Glu Pro Lys Glu Lys Arg Ala Pro Lys Ala Ser Trp Ser 
                245                 250                 255     


Phe Gln Tyr Phe Val Ala Leu Gln Thr Ile Asn Asn Leu Arg Leu Ile 
            260                 265                 270         


Ser Lys Asp Arg Ile Glu Glu Leu Ser Phe Glu Glu Lys Lys Gln Ile 
        275                 280                 285             


Met Asn Leu Ala Leu Glu Lys Ser Ile Val Lys Tyr Ile Asp Ile Arg 
    290                 295                 300                 


Lys Leu Leu Ser Val Pro Asn Glu Phe Gln Phe Asn Ser Leu Ser Tyr 
305                 310                 315                 320 


Ser Ala Asp Thr Val Asp Thr Ala Val Glu Ser Arg Lys Cys Ile Glu 
                325                 330                 335     


Leu Lys Glu Tyr His Ser Ile Asn Lys Val Tyr Lys Gln Ile Tyr Gly 
            340                 345                 350         


Glu Asn Ala Leu Asn Leu Leu Pro Lys Tyr Tyr Asp Thr Ile Ala Tyr 
        355                 360                 365             


Gly Leu Thr Ile Phe Lys Asp Asp Lys Asp Ile Leu Glu Tyr Leu Gln 
    370                 375                 380                 


Asn Lys Tyr Val Asn Ala Lys Gly Lys Pro Ile Ser Asn Phe Ala Asn 
385                 390                 395                 400 


Lys Thr Tyr Asp Asp Thr Phe Ile Gln Ala Leu Leu Asn Leu Asn Phe 
                405                 410                 415     


Thr Lys Met Gly His Leu Ser Phe Lys Ala Leu Lys Asn Ile Ile Pro 
            420                 425                 430         


Phe Leu Glu Glu Gly Leu Ser Tyr Asp Lys Ala Cys Glu Lys Ala Gly 
        435                 440                 445             


Tyr Asn Phe Lys Gly Thr Ser Tyr Thr Glu Gln Thr Lys Tyr Leu Pro 
    450                 455                 460                 


Val Ile Pro Gln Asn Thr Asn Pro Val Val His Arg Ala Leu Ser Gln 
465                 470                 475                 480 


Thr Arg Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Asn 
                485                 490                 495     


Ala Ile His Ile Glu Thr Ala Arg Glu Leu Ser Lys Thr Phe Gln Glu 
            500                 505                 510         


Arg Lys Glu Ile Asp Ser Met Tyr Gln Asp Asn Ser Lys Lys Asn Glu 
        515                 520                 525             


His Ala Ile His Lys Leu Lys Glu Leu Gly Asn Ile Asn Pro Ser Gly 
    530                 535                 540                 


Ile Asn Ile Val Lys Phe Lys Leu Trp Asn Glu Gln Asp Gly Arg Cys 
545                 550                 555                 560 


Met Tyr Ser Gly Lys Tyr Ile Glu Pro His Arg Leu Phe Glu Glu Gly 
                565                 570                 575     


Tyr Thr Glu Val Asp His Ile Leu Pro Tyr Ser Arg Ser Leu Asp Asp 
            580                 585                 590         


Ser Tyr Asn Asn Lys Thr Leu Thr Leu Gly Thr Glu Asn Gln Arg Lys 
        595                 600                 605             


Gly Asn Lys Ile Pro Tyr Glu Tyr Met Gly Asn Thr Ser Ile Trp Asn 
    610                 615                 620                 


Asp Phe Glu Thr Arg Val Gln Ser Asn Lys Lys Ile Asn Lys Lys Lys 
625                 630                 635                 640 


Gln Gln Lys Leu Leu Leu Gln His Phe Ser Tyr Ala Arg Glu Gln Glu 
                645                 650                 655     


Phe Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Tyr Leu 
            660                 665                 670         


Ser Ser Leu Ile Gln Gln His Leu Ile Phe Ser Glu Ser Ser Arg Lys 
        675                 680                 685             


Lys Lys Val His Thr Val Ser Gly Ile Ile Thr Ser His Leu Arg Ser 
    690                 695                 700                 


Arg Trp Gly Phe Asn Lys Asp Arg Lys Glu Gly His Ile His His Ala 
705                 710                 715                 720 


Leu Asp Ala Val Ile Val Ala Val Thr Ser Asp His Met Ile Gln Arg 
                725                 730                 735     


Val Thr Lys Tyr Tyr Lys Leu Lys Glu Leu Asn Arg Asn Leu Gln Ala 
            740                 745                 750         


Lys Arg Met Pro Phe Pro Glu Pro Trp Glu Gly Phe Arg Leu Glu Leu 
        755                 760                 765             


Glu Ala Arg Ile Ser Pro Asn Thr Gln Gln Tyr Leu Lys Gly Leu Arg 
    770                 775                 780                 


Phe Lys Asn Tyr Ala Asp Val Asn Leu Ser Glu Ile Lys Ser Ile Phe 
785                 790                 795                 800 


Val Ser Arg Met Pro Lys His Ser Ile Thr Gly Glu Leu His Gln Glu 
                805                 810                 815     


Thr Ile Arg Lys Phe Ile Gly Tyr Asn Glu Lys Gly Lys Val Leu Thr 
            820                 825                 830         


Ala Ile Lys Thr Lys Leu Glu Asp Ile Pro Phe Asp Ala Asn Gly Asp 
        835                 840                 845             


Phe Pro Met Tyr Gly Lys Glu Ser Asp Leu Tyr Thr Tyr Asn Ala Ile 
    850                 855                 860                 


Lys Glu Arg Tyr Leu Ser His Lys Lys Asp Lys Arg Lys Ser Phe Gln 
865                 870                 875                 880 


Glu Pro Leu Tyr Lys Pro Thr Lys Ser Gly Gly Ile Gly Pro Leu Ile 
                885                 890                 895     


Lys Ser Ile Lys Ile Met Asp Thr Arg Thr Ile Val Asn Pro Val Asn 
            900                 905                 910         


Gln Gly Lys Gly Val Val Tyr Asn Ser Lys Ile Ala Arg Thr Asp Val 
        915                 920                 925             


Phe Lys Lys Glu Glu Lys Tyr Tyr Leu Ile Pro Ile Tyr Thr Ile Asp 
    930                 935                 940                 


Leu Met Lys Asn Ile Leu Pro Gln Lys Ala Ile Thr Ala Gly Lys Gly 
945                 950                 955                 960 


Tyr Glu Asp Trp Thr Thr Ile Asp Pro Ser Phe Thr Phe Leu Phe Ser 
                965                 970                 975     


Leu Phe Pro Asn Asp Leu Ile Gln Ile Val Pro Ser Lys Asn Lys Thr 
            980                 985                 990         


Ile Lys Ala Arg Thr Thr Val Ser  Lys Lys Glu Val Leu  Leu Pro Ser 
        995                 1000                 1005             


Leu Thr  Gly Tyr Phe Lys Gly  Val His Ser Gly Thr  Ala Gly Ile 
    1010                 1015                 1020             


Thr Val  Glu Thr His Asp Gly  Ser Val Ile Ala Asn  Val Gly Ser 
    1025                 1030                 1035             


Lys Gln  Leu Leu Leu Ile Glu  Lys Tyr Gln Val Asp  Val Leu Gly 
    1040                 1045                 1050             


Asn Tyr  Thr Lys Ile Lys Glu  Glu Lys Arg Ile Gly  Leu Thr Thr 
    1055                 1060                 1065             


Tyr Asn  Asp Asn Lys Lys Ile  Ala Ala Cys 
    1070                 1075             


<210> 70
<211> 1069
<212> PRT
<213> Bacillus cereus


<220>
<223> Bacillus cereus Rock1-15

<400> 70
Met Asn Tyr Asp Ile Gly Leu Arg Ile Gly Ile Thr Ser Cys Gly Trp 
1               5                   10                  15      


Ser Ile Ile Asn Lys Asp Leu Glu Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Val Phe Glu Lys Ala Glu Asn Pro Asp Gly Thr Ala Ser Ala Ala Pro 
        35                  40                  45              


Arg Arg Glu Ala Arg Lys Ser Arg Arg Lys His Arg Arg Lys Lys His 
    50                  55                  60                  


Arg Ile Glu Arg Ile Lys Arg Leu Ile Val Gln His Asp Leu Leu Ser 
65                  70                  75                  80  


Lys Lys Glu Leu Asp Ser Leu Tyr Leu Ser Pro Phe Asn Ile Asp Val 
                85                  90                  95      


Trp Asn Leu Gln Val Glu Ala Leu Glu Arg Lys Leu Asp Asn Arg Glu 
            100                 105                 110         


Phe Ala Arg Val Leu Ile His Leu Val Gln Arg Arg Gly Phe Gln Thr 
        115                 120                 125             


Ile Arg Lys Ser Val Glu Ile Gln Glu Glu Gly Lys Leu Leu Glu Asn 
    130                 135                 140                 


Val Ser Glu Asn Glu Arg Ile Met Lys Val Asn Gly Tyr Lys Thr Val 
145                 150                 155                 160 


Gly Glu Met Phe Ser Lys His Glu Lys Phe Thr His His Lys Arg Asn 
                165                 170                 175     


Lys Asp Gly Ser Tyr Thr Ser Val Val Thr Arg Ser Leu Leu Leu Lys 
            180                 185                 190         


Glu Ile Lys Thr Ile Phe Asn Ser Gln Arg Ile Leu Gly Asn Val Phe 
        195                 200                 205             


Ser Thr Gln Lys Leu Glu Ser Asp Tyr Leu Tyr Ile Trp Gly Ser Gln 
    210                 215                 220                 


Arg Pro Thr Leu Thr Tyr Glu Gln Leu Met Ser Met Val Gly Asn Cys 
225                 230                 235                 240 


Ile Tyr Glu Lys Lys Glu Lys Arg Ala Pro Lys Thr Ser Trp Ala Phe 
                245                 250                 255     


Gln Tyr Phe Ser Leu Leu Gln Lys Ile Asn Lys Leu Lys Val Ser Asp 
            260                 265                 270         


Asp Asn Thr Leu Arg Lys Leu Ser Lys Glu Glu Arg Asp Ile Val Ile 
        275                 280                 285             


Glu Leu Ala Phe Lys Lys Lys Asn Val Ser Phe Val Asp Ile Arg Lys 
    290                 295                 300                 


Ala Leu Lys Leu Asn Asp Asn Thr Lys Phe Asn His Leu Thr Tyr Ser 
305                 310                 315                 320 


His Val Val Glu Thr Lys Lys Val Glu Lys Ala Thr Phe Ile Glu Leu 
                325                 330                 335     


Lys Gly Tyr His Leu Ile Lys Lys Gln Leu Lys Asp Arg Asn Val Glu 
            340                 345                 350         


Leu Thr Gln Glu Leu Gln Pro Lys Asp Tyr Asp Ala Ile Ala Ala Ala 
        355                 360                 365             


Ser Thr Phe Phe Lys Asn Asp Ile Glu Phe Arg Asp Tyr Leu Arg Asn 
    370                 375                 380                 


Gln Tyr Leu Asp Ser Asn Gly Lys Arg Lys Ser Asn Ile Ala Asn Lys 
385                 390                 395                 400 


Val Phe Glu Asp Lys Val Ile Ala Ala Val Phe Glu Leu Asn Phe Ser 
                405                 410                 415     


Lys Val Cys His Leu Ser Phe Lys Ser Leu Tyr Lys Leu Ile Pro His 
            420                 425                 430         


Leu Glu Lys Gly Leu Asp Tyr Lys Glu Ala Ile Leu Cys Ala Gly Tyr 
        435                 440                 445             


Asn Phe Arg Asp Glu Asn Lys Arg Asp Lys Lys Leu Phe Leu Pro Val 
    450                 455                 460                 


Ile Gln Gln Glu Thr Asn Pro Val Val His Arg Ala Leu Thr Gln Ala 
465                 470                 475                 480 


Arg Lys Val Ile Asn Ala Ile Ile Arg Glu Tyr Gly Ser Pro Asn Thr 
                485                 490                 495     


Ile Arg Phe Val Val Ala Asn Asp Leu Ala Lys Thr Tyr Lys Gln Arg 
            500                 505                 510         


Lys Glu Leu Glu Ser Thr Leu Lys Lys Asn Arg Ala Glu Asn Glu Lys 
        515                 520                 525             


Ile Lys Thr Lys Leu Leu Ser Met Gly Ile Ile Asn Pro Thr Gly Met 
    530                 535                 540                 


Asp Ile Val Lys Tyr Lys Leu Trp Tyr Glu Gln Ser Gly Ile Cys Leu 
545                 550                 555                 560 


Tyr Thr Gly Arg Gln Met Glu Leu Ser Ser Leu Phe Lys Pro Gly Tyr 
                565                 570                 575     


Ser Ile Val Asn His Ile Ile Pro Tyr Asn Arg Ser Phe Asp Asp Thr 
            580                 585                 590         


Tyr His Asn Arg Val Leu Thr Leu Thr Glu Thr Lys Tyr Glu Lys Gly 
        595                 600                 605             


Asn Lys Ile Pro Phe Glu Tyr Phe Gly Ala Glu Glu Thr Cys Trp Asn 
    610                 615                 620                 


Glu Tyr Glu Lys Arg Val Ser Thr Ser Lys Lys Ile His Asp Lys Lys 
625                 630                 635                 640 


Arg Glu Lys Leu Leu Ile Arg Asn Phe Asp Ile Glu Tyr Glu Asn Glu 
                645                 650                 655     


Met Ile Ser Asn Asn Val Phe Asp Thr His Tyr Ile Gly Ser Tyr Phe 
            660                 665                 670         


Glu Lys Tyr Ile Asp Glu His Leu Gln Phe Lys Lys Ser Thr Lys Lys 
        675                 680                 685             


Gln Lys Val Phe Ser Ile His Gly Asn Met Val Ala His Leu His Ser 
    690                 695                 700                 


Arg Trp Gly Phe Asn Lys Asn Ser Arg Glu Ile Tyr Leu Asn His Ala 
705                 710                 715                 720 


Val Asp Ala Ala Ile Val Ala Val Leu Thr Asp Gln Leu Ile Arg Asn 
                725                 730                 735     


Ile Ala Asp Tyr Tyr Arg Arg Asp Asn Ile Leu Glu Gln Lys Gly Ser 
            740                 745                 750         


Leu Lys Phe Pro Glu Pro Trp Lys Ser Phe Ser Ile Glu Leu Glu Ala 
        755                 760                 765             


Arg Ile Ser Pro Gln Val Arg Asp Leu Ile Lys Lys Leu Asn Leu Asp 
    770                 775                 780                 


Ser Tyr Leu Asp Val Asp Ile Leu His Ile Lys Pro Val Phe Ile Ser 
785                 790                 795                 800 


Lys Lys Pro Arg Arg Lys Val Asn Gly Glu Ala His Lys Ser Thr Ile 
                805                 810                 815     


Arg Ser Leu Ile Gly Ile Asn Glu Ile Gly Lys Thr Val Thr Cys Ile 
            820                 825                 830         


Lys Thr Arg Leu Glu Asp Ile Pro Phe Asp Glu Asn Gly Asp Phe Pro 
        835                 840                 845             


Met Tyr Gly Lys Asp Thr Asp Lys Tyr Thr Tyr Thr Ala Ile Lys Glu 
    850                 855                 860                 


Arg Tyr Leu Glu Phe Asn Lys Asp Lys Glu Lys Ala Phe Ser Thr Pro 
865                 870                 875                 880 


Leu Tyr Lys Leu Lys Arg Asn Gly Glu Pro Gly Asn Gln Ile Lys Ser 
                885                 890                 895     


Val Lys Ile Ile Asp Thr Arg Asn Ile Val Asn Lys Val Asn Gln Gly 
            900                 905                 910         


Lys Gly Ile Ala Tyr Asn Ser Asn Ile Ile Arg Val Asp Val Phe Ser 
        915                 920                 925             


Arg Asp Gln Lys Tyr Tyr Val Val Pro Ile Tyr Leu Arg Asp Phe Ile 
    930                 935                 940                 


Lys Gly Ser Leu Pro Asn Lys Ile Ile Thr Ala Ala Lys Gly Phe Met 
945                 950                 955                 960 


Gln Trp Pro Glu Thr Asp Asn Ser Tyr Thr Phe Leu Phe Ser Ile Phe 
                965                 970                 975     


Pro Asn Asp Leu Ile Lys Val Val Pro Lys Glu Gly Lys Phe Ile Lys 
            980                 985                 990         


Ala Lys Asn Glu Asn Lys Glu Asn  Ile Asn Leu Thr Glu  Ile Leu Gly 
        995                 1000                 1005             


Tyr Phe  Lys Gly Leu Asp Ser  Ser Thr Gly Ala Phe  Thr Leu Glu 
    1010                 1015                 1020             


Ser His  Asp Gly Ser Leu Leu  Ala Arg Gly Ile Gly  Thr Lys Asn 
    1025                 1030                 1035             


Leu Leu  Leu Ile Glu Lys Tyr  Gln Val Asp Val Leu  Gly Arg Tyr 
    1040                 1045                 1050             


Asn Lys  Val Gly Asn Glu Glu  Arg Gln Asp Ile Lys  Ile Gln Gln 
    1055                 1060                 1065             


Asn 
    


<210> 71
<211> 1088
<212> PRT
<213> Bacillus smithii


<220>
<223> Bacillus smithii 7_3_47FAA

<400> 71
Met Asn Tyr Lys Met Gly Leu Asp Ile Gly Ile Ala Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Leu Asp Leu Lys Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Ile Phe Asp Lys Ala Glu His Pro Gln Asn Gly Glu Ser Leu Ala Leu 
        35                  40                  45              


Pro Arg Arg Ile Ala Arg Ser Ala Arg Arg Arg Leu Arg Arg Arg Lys 
    50                  55                  60                  


His Arg Leu Glu Arg Ile Arg Arg Leu Leu Val Ser Glu Asn Val Leu 
65                  70                  75                  80  


Thr Lys Glu Glu Met Asn Leu Leu Phe Lys Gln Lys Lys Gln Ile Asp 
                85                  90                  95      


Val Trp Gln Leu Arg Val Asp Ala Leu Glu Arg Lys Leu Asn Asn Asp 
            100                 105                 110         


Glu Leu Ala Arg Val Leu Leu His Leu Ala Lys Arg Arg Gly Phe Lys 
        115                 120                 125             


Ser Asn Arg Lys Ser Glu Arg Asn Ser Lys Glu Ser Ser Glu Phe Leu 
    130                 135                 140                 


Lys Asn Ile Glu Glu Asn Gln Ser Ile Leu Ala Gln Tyr Arg Ser Val 
145                 150                 155                 160 


Gly Glu Met Ile Val Lys Asp Ser Lys Phe Ala Tyr His Lys Arg Asn 
                165                 170                 175     


Lys Leu Asp Ser Tyr Ser Asn Met Ile Ala Arg Asp Asp Leu Glu Arg 
            180                 185                 190         


Glu Ile Lys Leu Ile Phe Glu Lys Gln Arg Glu Phe Asn Asn Pro Val 
        195                 200                 205             


Cys Thr Glu Arg Leu Glu Glu Lys Tyr Leu Asn Ile Trp Ser Ser Gln 
    210                 215                 220                 


Arg Pro Phe Ala Ser Lys Glu Asp Ile Glu Lys Lys Val Gly Phe Cys 
225                 230                 235                 240 


Thr Phe Glu Pro Lys Glu Lys Arg Ala Pro Lys Ala Thr Tyr Thr Phe 
                245                 250                 255     


Gln Ser Phe Ile Val Trp Glu His Ile Asn Lys Leu Arg Leu Val Ser 
            260                 265                 270         


Pro Asp Glu Thr Arg Ala Leu Thr Glu Ile Glu Arg Asn Leu Leu Tyr 
        275                 280                 285             


Lys Gln Ala Phe Ser Lys Asn Lys Met Thr Tyr Tyr Asp Ile Arg Lys 
    290                 295                 300                 


Leu Leu Asn Leu Ser Asp Asp Ile His Phe Lys Gly Leu Leu Tyr Asp 
305                 310                 315                 320 


Pro Lys Ser Ser Leu Lys Gln Ile Glu Asn Ile Arg Phe Leu Glu Leu 
                325                 330                 335     


Asp Ser Tyr His Lys Ile Arg Lys Cys Ile Glu Asn Val Tyr Gly Lys 
            340                 345                 350         


Asp Gly Ile Arg Met Phe Asn Glu Thr Asp Ile Asp Thr Phe Gly Tyr 
        355                 360                 365             


Ala Leu Thr Ile Phe Lys Asp Asp Glu Asp Ile Val Ala Tyr Leu Gln 
    370                 375                 380                 


Asn Glu Tyr Ile Thr Lys Asn Gly Lys Arg Val Ser Asn Leu Ala Asn 
385                 390                 395                 400 


Lys Val Tyr Asp Lys Ser Leu Ile Asp Glu Leu Leu Asn Leu Ser Phe 
                405                 410                 415     


Ser Lys Phe Ala His Leu Ser Met Lys Ala Ile Arg Asn Ile Leu Pro 
            420                 425                 430         


Tyr Met Glu Gln Gly Glu Ile Tyr Ser Lys Ala Cys Glu Leu Ala Gly 
        435                 440                 445             


Tyr Asn Phe Thr Gly Pro Lys Lys Lys Glu Lys Ala Leu Leu Leu Pro 
    450                 455                 460                 


Val Ile Pro Asn Ile Ala Asn Pro Val Val Met Arg Ala Leu Thr Gln 
465                 470                 475                 480 


Ser Arg Lys Val Val Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Val 
                485                 490                 495     


Ser Ile His Ile Glu Leu Ala Arg Asp Leu Ser His Ser Phe Asp Glu 
            500                 505                 510         


Arg Lys Lys Ile Gln Lys Asp Gln Thr Glu Asn Arg Lys Lys Asn Glu 
        515                 520                 525             


Thr Ala Ile Lys Gln Leu Ile Glu Tyr Glu Leu Thr Lys Asn Pro Thr 
    530                 535                 540                 


Gly Leu Asp Ile Val Lys Phe Lys Leu Trp Ser Glu Gln Gln Gly Arg 
545                 550                 555                 560 


Cys Met Tyr Ser Leu Lys Pro Ile Glu Leu Glu Arg Leu Leu Glu Pro 
                565                 570                 575     


Gly Tyr Val Glu Val Asp His Ile Leu Pro Tyr Ser Arg Ser Leu Asp 
            580                 585                 590         


Asp Ser Tyr Ala Asn Lys Val Leu Val Leu Thr Lys Glu Asn Arg Glu 
        595                 600                 605             


Lys Gly Asn His Thr Pro Val Glu Tyr Leu Gly Leu Gly Ser Glu Arg 
    610                 615                 620                 


Trp Lys Lys Phe Glu Lys Phe Val Leu Ala Asn Lys Gln Phe Ser Lys 
625                 630                 635                 640 


Lys Lys Lys Gln Asn Leu Leu Arg Leu Arg Tyr Glu Glu Thr Glu Glu 
                645                 650                 655     


Lys Glu Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ser Lys 
            660                 665                 670         


Phe Phe Ala Asn Phe Ile Lys Glu His Leu Lys Phe Ala Asp Gly Asp 
        675                 680                 685             


Gly Gly Gln Lys Val Tyr Thr Ile Asn Gly Lys Ile Thr Ala His Leu 
    690                 695                 700                 


Arg Ser Arg Trp Asp Phe Asn Lys Asn Arg Glu Glu Ser Asp Leu His 
705                 710                 715                 720 


His Ala Val Asp Ala Val Ile Val Ala Cys Ala Thr Gln Gly Met Ile 
                725                 730                 735     


Lys Lys Ile Thr Glu Phe Tyr Lys Ala Arg Glu Gln Asn Lys Glu Ser 
            740                 745                 750         


Ala Lys Lys Lys Glu Pro Ile Phe Pro Gln Pro Trp Pro His Phe Ala 
        755                 760                 765             


Asp Glu Leu Lys Ala Arg Leu Ser Lys Phe Pro Gln Glu Ser Ile Glu 
    770                 775                 780                 


Ala Phe Ala Leu Gly Asn Tyr Asp Arg Lys Lys Leu Glu Ser Leu Arg 
785                 790                 795                 800 


Pro Val Phe Val Ser Arg Met Pro Lys Arg Ser Val Thr Gly Ala Ala 
                805                 810                 815     


His Gln Glu Thr Leu Arg Arg Cys Val Gly Ile Asp Glu Gln Ser Gly 
            820                 825                 830         


Lys Ile Gln Thr Ala Val Lys Thr Lys Leu Ser Asp Ile Lys Leu Asp 
        835                 840                 845             


Lys Asp Gly His Phe Pro Met Tyr Gln Lys Glu Ser Asp Pro Arg Thr 
    850                 855                 860                 


Tyr Glu Ala Ile Arg Gln Arg Leu Leu Glu His Asn Asn Asp Pro Lys 
865                 870                 875                 880 


Lys Ala Phe Gln Glu Pro Leu Tyr Lys Pro Lys Lys Asn Gly Glu Pro 
                885                 890                 895     


Gly Pro Val Ile Arg Thr Val Lys Ile Ile Asp Thr Lys Asn Lys Val 
            900                 905                 910         


Val His Leu Asp Gly Ser Lys Thr Val Ala Tyr Asn Ser Asn Ile Val 
        915                 920                 925             


Arg Thr Asp Val Phe Glu Lys Asp Gly Lys Tyr Tyr Cys Val Pro Val 
    930                 935                 940                 


Tyr Thr Met Asp Ile Met Lys Gly Thr Leu Pro Asn Lys Ala Ile Glu 
945                 950                 955                 960 


Ala Asn Lys Pro Tyr Ser Glu Trp Lys Glu Met Thr Glu Glu Tyr Thr 
                965                 970                 975     


Phe Gln Phe Ser Leu Phe Pro Asn Asp Leu Val Arg Ile Val Leu Pro 
            980                 985                 990         


Arg Glu Lys Thr Ile Lys Thr Ser  Thr Asn Glu Glu Ile  Ile Ile Lys 
        995                 1000                 1005             


Asp Ile  Phe Ala Tyr Tyr Lys  Thr Ile Asp Ser Ala  Thr Gly Gly 
    1010                 1015                 1020             


Leu Glu  Leu Ile Ser His Asp  Arg Asn Phe Ser Leu  Arg Gly Val 
    1025                 1030                 1035             


Gly Ser  Lys Thr Leu Lys Arg  Phe Glu Lys Tyr Gln  Val Asp Val 
    1040                 1045                 1050             


Leu Gly  Asn Ile His Lys Val  Lys Gly Glu Lys Arg  Val Gly Leu 
    1055                 1060                 1065             


Ala Ala  Pro Thr Asn Gln Lys  Lys Gly Lys Thr Val  Asp Ser Leu 
    1070                 1075                 1080             


Gln Ser  Val Ser Asp 
    1085             


<210> 72
<211> 1069
<212> PRT
<213> Bacillus thuringiensis

<400> 72
Met Asn Tyr Asp Ile Gly Leu Arg Ile Gly Ile Thr Ser Cys Gly Trp 
1               5                   10                  15      


Ser Ile Ile Asn Lys Asp Leu Glu Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Val Phe Glu Lys Ala Glu Asn Pro Asp Gly Thr Ala Ser Ala Ala Pro 
        35                  40                  45              


Arg Arg Glu Ala Arg Lys Ser Arg Arg Lys His Arg Arg Lys Lys His 
    50                  55                  60                  


Arg Ile Glu Arg Ile Lys Arg Leu Ile Val Gln His Asp Leu Leu Ser 
65                  70                  75                  80  


Lys Lys Glu Leu Asp Ser Leu Tyr Leu Ser Pro Phe Asn Ile Asp Val 
                85                  90                  95      


Trp Asn Leu Arg Val Glu Ala Leu Glu Arg Lys Leu Asp Asn Arg Glu 
            100                 105                 110         


Phe Ala Arg Val Leu Ile His Leu Val Gln Arg Arg Gly Phe Gln Thr 
        115                 120                 125             


Ile Arg Lys Ser Val Glu Ile Gln Glu Glu Gly Lys Leu Leu Glu Asn 
    130                 135                 140                 


Val Ser Glu Asn Glu Arg Ile Met Lys Val Asn Gly Tyr Lys Thr Val 
145                 150                 155                 160 


Gly Glu Met Phe Ser Lys His Glu Lys Phe Thr His His Lys Arg Asn 
                165                 170                 175     


Lys Asp Gly Ser Tyr Thr Ser Val Val Thr Arg Ser Leu Leu Leu Lys 
            180                 185                 190         


Glu Ile Lys Thr Ile Phe Asn Ser Gln Arg Ile Leu Gly Asn Val Phe 
        195                 200                 205             


Ser Thr Gln Lys Leu Glu Ser Asp Tyr Leu Tyr Ile Trp Gly Ser Gln 
    210                 215                 220                 


Arg Pro Thr Leu Thr Tyr Glu Gln Leu Met Ser Met Val Gly Asn Cys 
225                 230                 235                 240 


Ile Tyr Glu Lys Lys Glu Lys Arg Ala Pro Lys Thr Ser Trp Ala Phe 
                245                 250                 255     


Gln Tyr Phe Ser Leu Leu Gln Lys Ile Asn Lys Leu Lys Val Ser Asp 
            260                 265                 270         


Asp Asn Thr Leu Arg Lys Leu Ser Lys Glu Glu Arg Asp Ile Val Ile 
        275                 280                 285             


Glu Leu Ala Phe Lys Lys Lys Asn Val Ser Phe Val Asp Ile Arg Lys 
    290                 295                 300                 


Ala Leu Lys Leu Asn Asp Asn Thr Lys Phe Asn His Leu Thr Tyr Ser 
305                 310                 315                 320 


His Val Val Glu Thr Lys Lys Val Glu Lys Ala Thr Phe Ile Glu Leu 
                325                 330                 335     


Lys Gly Tyr His Leu Ile Lys Lys Gln Leu Lys Asp Arg Asn Val Glu 
            340                 345                 350         


Leu Thr Gln Glu Leu Gln Pro Lys Asp Tyr Asp Ala Ile Ala Ala Ala 
        355                 360                 365             


Ser Thr Phe Phe Lys Asn Asp Ile Glu Phe Arg Asp Tyr Leu Arg Asn 
    370                 375                 380                 


Gln Tyr Leu Asp Ser Asn Gly Lys Arg Lys Ser Asn Ile Ala Asn Lys 
385                 390                 395                 400 


Val Phe Glu Asp Lys Val Ile Ala Ala Val Phe Glu Leu Asn Phe Ser 
                405                 410                 415     


Lys Val Cys His Leu Ser Phe Lys Ser Leu Tyr Lys Leu Ile Pro His 
            420                 425                 430         


Leu Glu Lys Gly Leu Asp Tyr Lys Glu Ala Ile Leu Cys Ala Gly Tyr 
        435                 440                 445             


Asn Phe Arg Asp Glu Asn Lys Arg Asp Lys Lys Leu Phe Leu Pro Val 
    450                 455                 460                 


Ile Gln Gln Glu Thr Asn Pro Val Val His Arg Ala Leu Thr Gln Ala 
465                 470                 475                 480 


Arg Lys Val Ile Asn Ala Ile Ile Arg Glu Tyr Gly Ser Pro Asn Thr 
                485                 490                 495     


Ile Arg Phe Val Val Ala Asn Asp Leu Ala Lys Thr Tyr Lys Gln Arg 
            500                 505                 510         


Lys Glu Leu Glu Ser Thr Leu Lys Lys Asn Arg Ala Glu Asn Glu Lys 
        515                 520                 525             


Ile Lys Thr Lys Leu Leu Ser Met Gly Ile Ile Asn Pro Thr Gly Met 
    530                 535                 540                 


Asp Ile Val Lys Tyr Lys Leu Trp Tyr Glu Gln Ser Gly Ile Cys Leu 
545                 550                 555                 560 


Tyr Thr Gly Arg Gln Met Glu Leu Ser Ser Leu Phe Lys Pro Gly Tyr 
                565                 570                 575     


Ser Ile Val Asn His Ile Ile Pro Tyr Asn Arg Ser Phe Asp Asp Thr 
            580                 585                 590         


Tyr His Asn Arg Val Leu Thr Leu Thr Glu Thr Lys Tyr Glu Lys Gly 
        595                 600                 605             


Asn Lys Ile Pro Phe Glu Tyr Phe Gly Ala Glu Glu Thr Cys Trp Asn 
    610                 615                 620                 


Glu Tyr Glu Lys Arg Val Ser Thr Ser Lys Lys Ile His Asp Lys Lys 
625                 630                 635                 640 


Arg Glu Lys Leu Leu Ile Arg Asn Phe Asp Ile Glu Tyr Glu Asn Glu 
                645                 650                 655     


Met Ile Ser Asn Asn Val Phe Asp Thr His Tyr Ile Gly Ser Tyr Phe 
            660                 665                 670         


Glu Lys Tyr Ile Asp Glu His Leu Gln Phe Lys Lys Ser Thr Lys Lys 
        675                 680                 685             


Gln Lys Val Phe Ser Ile His Gly Asn Met Val Ala His Leu His Ser 
    690                 695                 700                 


Arg Trp Gly Phe Asn Lys Asn Ser Arg Glu Ile Tyr Leu Asn His Ala 
705                 710                 715                 720 


Val Asp Ala Ala Ile Val Ala Val Leu Thr Asp Gln Leu Ile Arg Asn 
                725                 730                 735     


Ile Ala Asp Tyr Tyr Arg Arg Asp Asn Ile Leu Glu Gln Lys Gly Ser 
            740                 745                 750         


Leu Lys Phe Pro Glu Pro Trp Lys Ser Phe Ser Ile Glu Leu Glu Ala 
        755                 760                 765             


Arg Ile Ser Pro Gln Val Arg Asp Leu Ile Lys Lys Leu Asn Leu Asp 
    770                 775                 780                 


Ser Tyr Leu Asp Val Asp Ile Leu His Ile Lys Pro Val Phe Ile Ser 
785                 790                 795                 800 


Lys Lys Pro Arg Arg Lys Val Asn Gly Glu Ala His Lys Ser Thr Ile 
                805                 810                 815     


Arg Ser Leu Ile Gly Ile Asn Glu Ile Gly Lys Thr Val Thr Cys Ile 
            820                 825                 830         


Lys Thr Arg Leu Glu Asp Ile Pro Phe Asp Glu Asn Gly Asp Phe Pro 
        835                 840                 845             


Met Tyr Gly Lys Asp Thr Asp Lys Tyr Thr Tyr Thr Ala Ile Lys Glu 
    850                 855                 860                 


Arg Tyr Leu Glu Phe Asn Lys Asp Lys Glu Lys Ala Phe Ser Thr Pro 
865                 870                 875                 880 


Leu Tyr Lys Leu Lys Arg Asn Gly Glu Pro Gly Asn Gln Ile Lys Ser 
                885                 890                 895     


Val Lys Ile Ile Asp Thr Arg Asn Ile Val Asn Lys Val Asn Gln Gly 
            900                 905                 910         


Lys Gly Ile Ala Tyr Asn Ser Asn Ile Ile Arg Val Asp Val Phe Ser 
        915                 920                 925             


Arg Asp Gln Lys Tyr Tyr Val Val Pro Ile Tyr Leu Arg Asp Phe Ile 
    930                 935                 940                 


Lys Gly Ser Leu Pro Asn Lys Ile Ile Thr Ala Ala Lys Gly Phe Met 
945                 950                 955                 960 


Gln Trp Pro Glu Thr Asp Asn Ser Tyr Thr Phe Leu Phe Ser Ile Phe 
                965                 970                 975     


Pro Asn Asp Leu Ile Lys Val Val Pro Lys Glu Gly Lys Phe Ile Lys 
            980                 985                 990         


Ala Lys Asn Glu Asn Lys Glu Asn  Ile Asn Leu Thr Glu  Ile Leu Gly 
        995                 1000                 1005             


Tyr Phe  Lys Gly Leu Asp Ser  Ser Thr Gly Ala Phe  Thr Leu Glu 
    1010                 1015                 1020             


Ser His  Asp Gly Ser Leu Leu  Ala Arg Gly Ile Gly  Thr Lys Asn 
    1025                 1030                 1035             


Leu Leu  Leu Ile Glu Lys Tyr  Gln Val Asp Val Leu  Gly Arg Tyr 
    1040                 1045                 1050             


Asn Lys  Val Gly Asn Glu Glu  Arg Gln Asp Ile Lys  Ile Gln Gln 
    1055                 1060                 1065             


Asn 
    


<210> 73
<211> 1509
<212> PRT
<213> Bacteroides coprophilus


<220>
<223> Bacteroides coprophilus DSM 18228

<400> 73
Met Lys Lys Thr Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Ser Asn Ile Asp Ser Glu Gly Lys Glu Lys Leu Val 
            20                  25                  30          


Gly Ile Ser Ser Cys Gly Ser Arg Ile Ile Pro Met Asp Ala Thr Thr 
        35                  40                  45              


Leu Gly Asp Phe Gly Lys Gly Asn Thr Lys Ser Pro Val Ala Glu Arg 
    50                  55                  60                  


Thr Arg Leu Arg Gly Ile Arg Arg Leu Leu Glu Arg Ser Leu Leu Arg 
65                  70                  75                  80  


Arg Glu Arg Leu His Arg Val Leu Ser Val Met Gly Phe Leu Pro Glu 
                85                  90                  95      


His Tyr Ala Ser Gln Leu Asp Arg Tyr Gly Lys Phe Leu Pro Glu Thr 
            100                 105                 110         


Glu Pro Lys Leu Ala Trp Tyr Lys Asp Asp Ser Gly Arg Tyr Gln Phe 
        115                 120                 125             


Leu Phe Gln Lys Ser Phe His Glu Met Leu Glu Asp Phe Arg Gln His 
    130                 135                 140                 


Gln Pro Glu Leu Val Ala Gly Glu Lys Lys Ile Pro Tyr Asp Trp Thr 
145                 150                 155                 160 


Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Gln Glu Ile Thr Lys Glu 
                165                 170                 175     


Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr 
            180                 185                 190         


Gln Leu Arg Gly Glu Glu Glu Gln Glu Glu Asn Asn Lys Ser Val Glu 
        195                 200                 205             


Tyr His Ala Leu Lys Val Val Ser Val Glu Asp Ser Gly Glu Arg Lys 
    210                 215                 220                 


Gly Lys Asp Ile Trp Tyr Asn Val Thr Leu Glu Asn Gly Trp Val Tyr 
225                 230                 235                 240 


Arg Arg Ala Ser Asn Ile Pro Leu Asp Trp Thr Gly Lys Val Lys Glu 
                245                 250                 255     


Phe Val Val Thr Thr Glu Leu Asp Asp Ala Gly Asn Pro Lys Lys Asp 
            260                 265                 270         


Lys Glu Gly Asn Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp Asp 
        275                 280                 285             


Trp Gly Leu Leu Lys Thr Arg Thr Gln Ala Gln Ile Asp Glu Ser Gly 
    290                 295                 300                 


Lys Thr Val Gly Thr Tyr Ile Tyr Glu Ser Leu Leu Cys Met Pro Asn 
305                 310                 315                 320 


Gln Lys Ile Arg Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Tyr Tyr 
                325                 330                 335     


Lys Asp Glu Leu Arg Gln Ile Leu Val Lys Gln Ser Glu Phe His Ala 
            340                 345                 350         


Ala Leu Gln Asp His Asn Leu Leu Leu Ser Cys Ile Glu Glu Leu Tyr 
        355                 360                 365             


Pro Asn Asn Glu Ala His Arg Arg Leu Leu Ser Ala Ser Ser Phe Ile 
    370                 375                 380                 


Tyr Phe Leu Ile Glu Asp Ile Leu Phe Tyr Gln Arg Pro Leu Lys Ser 
385                 390                 395                 400 


Gln Lys Gly Leu Ile Asp Asn Cys Pro Tyr Glu Ser His Ile Tyr Lys 
                405                 410                 415     


Asp Lys Lys Asp Gly Ser Leu His His Val Pro Leu Lys Cys Val Ser 
            420                 425                 430         


Lys Ser His Pro Leu Phe Gln Glu Phe Arg Leu Trp Gln Phe Leu Ser 
        435                 440                 445             


Asn Leu Arg Ile Tyr Gln Arg Glu Arg Met Met Asp Gly Ser Leu Lys 
    450                 455                 460                 


Leu Asp Val Asp Val Thr Arg Glu Phe Leu Pro Ser Glu Glu Asp Tyr 
465                 470                 475                 480 


Val Lys Leu Phe Asp Trp Leu Asn Glu Arg Lys Glu Ile Ser Gln Lys 
                485                 490                 495     


Phe Leu Leu Ala Tyr Lys Pro Phe Gly Leu Lys Lys Asn Glu Gln Ala 
            500                 505                 510         


Asn Tyr Arg Trp Asn Tyr Val Glu Asp Lys Ser Tyr Pro Cys Asn Glu 
        515                 520                 525             


Thr Arg Ala Glu Ile Lys Ser Arg Leu Ser Lys Ala Gly Val Pro Glu 
    530                 535                 540                 


Glu Phe Leu Thr Glu Glu Lys Glu Glu Ala Leu Trp His Ile Leu Tyr 
545                 550                 555                 560 


Ser Ile Ser Asp Lys Lys Glu Leu Thr Lys Ala Leu Gly Thr Phe Ala 
                565                 570                 575     


Ala Lys Asn Cys Leu Asn Glu Ser Phe Val Glu Val Phe Ala Lys Ile 
            580                 585                 590         


Pro Pro Phe Glu Ser Asn Tyr Ala Ala Tyr Ser Leu Lys Ala Ile Arg 
        595                 600                 605             


Lys Leu Leu Ala Leu Met Arg Met Gly Lys Tyr Trp Asn Glu Gln Ala 
    610                 615                 620                 


Ile Asp Arg Gln Thr Arg Asp Arg Ile Glu Lys Ile Leu Thr Gly Glu 
625                 630                 635                 640 


Tyr Asp Glu Thr Ile Arg Ser Arg Val Arg Glu Lys Ala Met Leu Leu 
                645                 650                 655     


Thr Asp Ile Ser Ser Phe Arg Gly Leu Pro Leu Trp Leu Ala Cys Tyr 
            660                 665                 670         


Ile Val Tyr Asp Arg His Ser Glu Ser Lys Glu Leu Val Lys Trp Glu 
        675                 680                 685             


Thr Pro Ala Asp Ile Asp His Phe Leu Ser Lys Phe Lys Gln Asn Ser 
    690                 695                 700                 


Leu Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Ser Leu Arg Thr 
705                 710                 715                 720 


Val Arg Asp Ile Trp Lys Gln Glu Gly Lys Ile Asp Glu Ile His Val 
                725                 730                 735     


Glu Leu Gly Arg Glu Met Lys Asn Pro Ala Lys Glu Arg Ala Arg Ile 
            740                 745                 750         


Thr Ala Gln Val Gln Glu Asn Glu Asn Thr Asn Leu Arg Ile Lys Ala 
        755                 760                 765             


Leu Leu Ala Glu Phe Met Asn Pro Glu Phe Glu Ile Glu Asn Val His 
    770                 775                 780                 


Pro Tyr Ser Pro Gly Gln Gln Glu Ile Leu Arg Ile Tyr Glu Asp Gly 
785                 790                 795                 800 


Val Leu Ser Gly Ile Ala Glu Lys Asp Leu Pro Asp Asp Ile Thr Ala 
                805                 810                 815     


Ile Leu Lys Lys Phe Arg Glu Asn Asp Val Lys Lys Arg Pro Thr Thr 
            820                 825                 830         


Ser Glu Val Leu Arg Tyr Lys Leu Trp Leu Glu Gln Arg Tyr Arg Ser 
        835                 840                 845             


Pro Tyr Thr Gly Arg Val Ile Pro Leu Gly Lys Leu Phe Thr Pro Ala 
    850                 855                 860                 


Tyr Glu Ile Glu His Val Ile Pro Gln Ser Arg Tyr Phe Asp Asp Ser 
865                 870                 875                 880 


Ile Ser Asn Lys Val Ile Cys Glu Ser Ala Val Asn Lys Leu Lys Asp 
                885                 890                 895     


Asn Cys Leu Gly Tyr Glu Phe Ile Lys Lys His Ser Gly Glu Met Val 
            900                 905                 910         


Glu Leu Gly Asn Gly Glu Thr Val Pro Val Phe Ser Val Glu Glu Tyr 
        915                 920                 925             


Glu Arg Phe Val Lys Glu Ser Tyr Phe Gly Asn Ser Lys Lys Met Lys 
    930                 935                 940                 


Lys Leu Leu Leu Glu Asp Ile Pro Asp Ser Phe Ile Glu Arg Gln Leu 
945                 950                 955                 960 


Asn Asp Ser Arg Tyr Ile Ser Arg Val Val Thr Ser Leu Leu Ser Asn 
                965                 970                 975     


Leu Val Cys Glu Glu Gly Glu Gln Asp Gly Leu Ser Lys Asn Val Ile 
            980                 985                 990         


Val Cys Thr Gly Gly Ile Thr Asp  Arg Leu Lys Lys Asp  Trp Gly Val 
        995                 1000                 1005             


Gln Glu  Val Trp Asn Arg Ile  Ile Leu Pro Arg Phe  Leu Arg Leu 
    1010                 1015                 1020             


Asn Glu  Ile Thr Gly Arg Thr  Asp Phe Thr Ser Thr  Ser Val Asn 
    1025                 1030                 1035             


Gly His  Leu Leu Pro Ala Leu  Pro Leu Tyr Leu Gln  Lys Gly Phe 
    1040                 1045                 1050             


Asn Lys  Lys Arg Ile Asp His  Arg His His Ala Met  Asp Ala Ile 
    1055                 1060                 1065             


Val Ile  Ala Cys Ala Asn Arg  Asn Ile Val Asn Tyr  Leu Asn Asn 
    1070                 1075                 1080             


Ser Ser  Ala Arg Lys Asn Ser  Glu Ile Ser Arg Tyr  Asp Leu Gln 
    1085                 1090                 1095             


Arg Leu  Leu Cys Glu Lys Val  Lys Thr Asp Ala Asn  Gly Asn Tyr 
    1100                 1105                 1110             


Lys Trp  Ile Leu Arg Lys Pro  Trp Glu Thr Phe Thr  Gln Asp Val 
    1115                 1120                 1125             


Tyr Ala  Ala Leu Thr Asn Ile  Val Val Ser Phe Lys  Gln Asn Leu 
    1130                 1135                 1140             


Arg Val  Ile Asn Arg Thr Thr  Asn Tyr Tyr Gln His  Tyr Asn Glu 
    1145                 1150                 1155             


Ala Gly  Glu Lys Arg Met Ile  Pro Gln Thr Lys Gly  Asp Arg Trp 
    1160                 1165                 1170             


Ala Ile  Arg Lys Pro Met His  Lys Asp Thr Val Tyr  Gly Glu Val 
    1175                 1180                 1185             


Asn Leu  Arg Lys Glu Lys Thr  Leu Pro Leu Arg Asp  Val Val Lys 
    1190                 1195                 1200             


Asn Pro  Ser Ile Val Val Asp  Lys Ser Leu Lys Asn  Lys Leu Tyr 
    1205                 1210                 1215             


Glu Leu  Leu Lys Ser Gln Tyr  Asp Leu Lys Ala Ile  Ala Lys Tyr 
    1220                 1225                 1230             


Phe Glu  Thr His Gln Asp Val  Trp Ala Asp Val Asn  Leu Lys Lys 
    1235                 1240                 1245             


Ile Lys  Val Tyr Tyr Phe Thr  Lys Glu Thr Asn Glu  Arg Phe Phe 
    1250                 1255                 1260             


Ala Thr  Arg Lys Ser Leu Asp  Pro Ser Phe Asp Gln  Lys Lys Ile 
    1265                 1270                 1275             


Glu Glu  Glu Val Thr Asp Thr  Gly Val Gln Lys Ile  Leu Leu His 
    1280                 1285                 1290             


His Leu  Gln Gln Asn Asn Asn  Asp Pro Asp Met Ala  Phe Ser Pro 
    1295                 1300                 1305             


Asp Gly  Ile Asp Arg Met Asn  Gln Asn Met Thr Ile  Leu Asn Asp 
    1310                 1315                 1320             


Gly Lys  Trp His Gln Pro Ile  Tyr Lys Val Arg Thr  Tyr Glu Lys 
    1325                 1330                 1335             


Ala Asp  Lys Phe Ala Val Gly  Glu Ser Gly Asn Lys  Ala Lys Lys 
    1340                 1345                 1350             


Phe Val  Glu Ala Ala Lys Gly  Thr Asn Leu Phe Phe  Ala Val Tyr 
    1355                 1360                 1365             


Glu Ser  Val Gln Glu Asp Glu  Ala Ile Gly Lys Gln  Val Cys Lys 
    1370                 1375                 1380             


Arg Thr  Phe Ala Thr Ile Pro  Leu Asn Glu Val Ile  Lys Arg Lys 
    1385                 1390                 1395             


Lys Gln  Gly Leu Pro Ala Ala  Pro Glu Asp Leu Asn  Gly Asn Leu 
    1400                 1405                 1410             


Pro Lys  Phe Val Leu Ser Pro  Asn Asp Leu Val Tyr  Leu Pro Thr 
    1415                 1420                 1425             


Glu Glu  Glu Arg Asn Ser Ser  Arg Ile Ile Gln Pro  Leu Asp Arg 
    1430                 1435                 1440             


Glu Arg  Ile Tyr Lys Met Val  Ser Ser Ser Gly Ser  Gln Cys Phe 
    1445                 1450                 1455             


Phe Ile  Lys Val Phe Val Ala  Asn Ser Ile Trp Asp  Lys Asn Glu 
    1460                 1465                 1470             


Tyr Ser  Ser Leu Asn Lys Met  Glu Arg Ala Ile Thr  Asn Glu Met 
    1475                 1480                 1485             


Ile Lys  Glu Ile Cys Val Pro  Ile Lys Ile Asp Arg  Leu Gly Asn 
    1490                 1495                 1500             


Val Ser  Leu Ile Gln Ile 
    1505                 


<210> 74
<211> 1504
<212> PRT
<213> Bacteroides coprosuis


<220>
<223> Bacteroides coprosuis DSM 18011

<400> 74
Met Lys Lys Val Leu Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Val Asn Gln Asn Asp Lys Gly Glu Phe Leu Ser Ile Glu Lys 
            20                  25                  30          


Ile Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Val Met Asp Lys Phe 
        35                  40                  45              


Gly Ala Gly Gln Thr Glu Ser Ser Thr Ala Gln Arg Thr Gln Tyr Arg 
    50                  55                  60                  


Gly Val Arg Arg Leu Arg Glu Arg Ser Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu His Ile Leu His Phe Leu Pro Gln His Tyr Asp Ala 
                85                  90                  95      


Ala Ile Gly Trp Asn Lys Lys Glu Asn Lys Thr Tyr Gly Lys Phe Leu 
            100                 105                 110         


Pro Gly Val Glu Val Asn Ile Pro Trp Val Ala Thr Asp Gln Gly His 
        115                 120                 125             


Gln Phe Ile Phe Met Asp Ser Tyr Ala Glu Met Leu Lys Asp Leu Lys 
    130                 135                 140                 


Gln His Gln Pro His Leu Phe Glu Lys Ser Ser Thr Pro Val Pro Leu 
145                 150                 155                 160 


Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Gln Ala Ile 
                165                 170                 175     


Ser Lys Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg 
            180                 185                 190         


Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Val Glu Asp Asn Thr Lys Arg 
        195                 200                 205             


Glu Glu Phe Tyr Ala Leu Lys Val Val Lys Val Glu Leu Asp Lys Asp 
    210                 215                 220                 


Asn Thr Ser Ala Lys Thr Trp Tyr Lys Val His Leu Glu Asn Gly Phe 
225                 230                 235                 240 


Ile Tyr Pro Cys Pro Ser Asp Thr Pro Ile Asp Ser Trp Val Gly Met 
                245                 250                 255     


Val Lys Asp Phe Ile Val Thr Thr Thr Leu Glu Lys Asp Gly Ser Glu 
            260                 265                 270         


Lys Arg Thr Ala Asp Gly Glu Ile Lys Arg Ser Phe Arg Ala Pro Lys 
        275                 280                 285             


Glu Asp Asp Trp Thr Leu Leu Lys Lys Lys Thr Glu Ser Glu Leu Glu 
    290                 295                 300                 


Lys Ser Gly Lys Gln Val Gly Ala Phe Ile Tyr Asp Thr Leu Leu Ser 
305                 310                 315                 320 


Asn Pro Asp Gln Lys Ile Ile Gly Gly Leu Ile Lys Thr Ile Glu Arg 
                325                 330                 335     


Lys Tyr Tyr Lys Lys Glu Leu Glu Gln Ile Leu Glu Thr Gln Gln Lys 
            340                 345                 350         


Phe Ile Ala Glu Leu Ser Asp Lys Lys Leu Phe Gln Ala Cys Ala Glu 
        355                 360                 365             


Glu Leu Tyr Pro Leu Asn Asp Ser His Arg Glu Asn Leu Leu Glu Arg 
    370                 375                 380                 


Asp Phe Lys His Leu Phe Val Gln Asp Ile Ile Phe Tyr His Arg Pro 
385                 390                 395                 400 


Leu Lys Thr Lys Lys Ser Leu Ile Ser Asn Cys Thr Tyr Glu Tyr Arg 
                405                 410                 415     


Thr Phe Tyr Lys Asn Gly Glu Lys Gln Ile Ser Pro Ile Lys Cys Ile 
            420                 425                 430         


Ala Lys Ser Asn Pro Leu Phe Gln Glu Phe Arg Val Trp Gln Phe Val 
        435                 440                 445             


Gln Asn Leu Arg Ile Leu Gln Arg Gln Arg Ser Glu Gly Asp Ser Ile 
    450                 455                 460                 


Lys Tyr Asn Val Asp Val Thr Ala Glu Phe Leu Lys Asp Glu Asn Asp 
465                 470                 475                 480 


Ile Ala Asn Leu Phe Thr Trp Leu Asn Glu Arg Lys Val Ile Lys Gln 
                485                 490                 495     


Asp Gln Leu Leu Lys Ser Tyr Phe Lys Leu Lys Val Asn Lys Glu Thr 
            500                 505                 510         


Lys Glu Leu Asp Tyr Arg Trp Asn Tyr Val Asp Asp Lys Asn Lys Glu 
        515                 520                 525             


Tyr Pro Cys Asn Ala Thr Arg Thr His Ile Leu Ser Phe Leu Glu Lys 
    530                 535                 540                 


Cys Lys Glu Glu Lys Arg Ile Glu Asp Asp Arg Phe Val Tyr Ser Leu 
545                 550                 555                 560 


Trp His Leu Leu Tyr Ser Val Val Glu Pro Ile Glu Leu Arg Gly Ala 
                565                 570                 575     


Leu Ala Lys Phe Ala Glu Arg Glu His Leu His Pro Ser Phe Val Asp 
            580                 585                 590         


Val Phe Ala Gln Phe Pro Pro Leu Glu Lys Glu Tyr Gly Ser Tyr Ser 
        595                 600                 605             


Glu Lys Ala Ile Lys Arg Leu Leu Pro Leu Met Arg Met Gly Asp Tyr 
    610                 615                 620                 


Trp His Glu Asp Lys Ile Asp Val Lys Thr Lys Gln Arg Ile Gln Arg 
625                 630                 635                 640 


Ile Ile Asp Gly Glu Ala Asp Asp Asp Ile Thr His Arg Ser Arg Glu 
                645                 650                 655     


Lys Val Glu Asn Leu Arg Ser Ile Thr Asp Phe Lys Gly Leu Pro Leu 
            660                 665                 670         


Trp Lys Ala Gly Tyr Val Val Tyr Asn Arg His Ser Glu Ser Gly Glu 
        675                 680                 685             


Leu Thr Lys Trp Lys Thr Pro His Glu Leu Ser Asn Tyr Ile Gln Asn 
    690                 695                 700                 


Glu Phe Lys Gln Tyr Ser Leu Arg Asn Pro Ile Val Glu Gln Ile Val 
705                 710                 715                 720 


Leu Glu Thr Leu Arg Val Val His Asp Leu Trp Val Lys His Gly Asp 
                725                 730                 735     


Phe Ser Glu Ile His Leu Glu Leu Gly Arg Asp Ile Lys Asn Ser Ser 
            740                 745                 750         


Asp Lys Arg Lys Arg Met Ala Glu Arg Gln Gln Glu Asn Glu Asn Ser 
        755                 760                 765             


Arg Gln Arg Val Leu Glu Met Leu Ile Asp Leu Lys Lys Glu Ala Ala 
    770                 775                 780                 


Phe Ala Asp Leu Asn Pro Tyr Ser Pro Ser Gln Gln Glu Lys Leu Arg 
785                 790                 795                 800 


Ile Val Glu Asp Gly Val Leu Arg Ser Asn Ile Glu Ile Pro Lys Asp 
                805                 810                 815     


Ile Glu Lys Ile Thr Lys Ser Ala Lys Pro Thr Ser Arg Glu Leu Thr 
            820                 825                 830         


Lys Tyr Arg Leu Trp Leu Asp Gln Lys Tyr Arg Ser Pro Tyr Thr Gly 
        835                 840                 845             


Gln Pro Ile Ser Leu Ala Gln Leu Phe Thr Ser Lys Tyr Glu Ile Glu 
    850                 855                 860                 


His Val Ile Pro Gln Ala Lys Tyr Phe Asp Asp Ser Phe Thr Asn Lys 
865                 870                 875                 880 


Val Ile Cys Glu Ser Glu Val Asn Lys Glu Lys Gly Ser Met Leu Ala 
                885                 890                 895     


His Glu Phe Ile Leu Lys Asn Gly Gly Ser Thr Val Asn Val Gly Gly 
            900                 905                 910         


Arg Gln Val Gln Val Leu Lys Asn Asp Ala Tyr Val Glu Leu Ile Asn 
        915                 920                 925             


Arg Leu Tyr Gly Lys Asn Asn Pro Val Lys Ala Lys Lys Leu Leu Ala 
    930                 935                 940                 


Glu Asp Ile Asp Glu Val Val Gly Asp Phe Ser Glu Arg Gln Leu Asn 
945                 950                 955                 960 


Asp Thr Arg Tyr Ile Ser Arg Val Val Gln Lys Leu Leu Ser Asn Ile 
                965                 970                 975     


Val Arg Glu Glu Asp Glu Gln Glu Ser Thr Ser Lys His Val Ile Gly 
            980                 985                 990         


Cys Ser Gly Gln Val Thr Thr Ala  Leu Lys Lys Asp Trp  Gly Leu Asn 
        995                 1000                 1005             


Asp Ile  Trp Asn Lys Ile Ile  Gln Pro Arg Phe Glu  Arg Leu Asn 
    1010                 1015                 1020             


Glu Met  Thr Ala Thr Glu Asp  Tyr Gly Val Trp Gln  Ser Pro Asn 
    1025                 1030                 1035             


His Phe  Gln Ile Arg Val Pro  Glu Glu Ile Gln Lys  Gly Phe Thr 
    1040                 1045                 1050             


Lys Lys  Arg Ile Asp His Arg  His His Ala Met Asp  Ala Leu Val 
    1055                 1060                 1065             


Ile Ala  Cys Ala Thr Arg Ser  His Ile Asn Tyr Ile  Ser Asn Arg 
    1070                 1075                 1080             


Ser Gly  Gln Asp Arg Asn Ala  Lys Phe Glu Thr Thr  Arg Thr Asp 
    1085                 1090                 1095             


Leu Arg  Ser Lys Leu Cys Tyr  Lys Glu Asn Ser Ser  Gly Asn Asn 
    1100                 1105                 1110             


Tyr Asn  Tyr Ile Phe Asn Lys  Pro Trp Asp Thr Phe  Thr Gln Asp 
    1115                 1120                 1125             


Ala His  Arg Ala Leu Glu Asn  Ile Val Val Ser His  Lys Gln Asn 
    1130                 1135                 1140             


Leu Arg  Val Leu Thr Lys Thr  Asn Asn Tyr Thr Gln  Phe Ile Asn 
    1145                 1150                 1155             


Lys Asp  Gly Lys Lys Asp Leu  Gln Lys Gln Val Lys  Gly Asp His 
    1160                 1165                 1170             


Phe Ala  Val Arg Lys Pro Met  His Gln Glu Thr Ile  Tyr Gly Arg 
    1175                 1180                 1185             


Val Ser  Ile Arg Ser Ile Lys  Glu Val Ala Leu Lys  Lys Ala Leu 
    1190                 1195                 1200             


Glu Asn  Trp Lys Gln Ile Val  Asp Arg Thr Leu Lys  Asp Lys Ile 
    1205                 1210                 1215             


Arg Glu  Leu Ile Gly Ala Tyr  Gly Lys Tyr Asp Ala  Gln Thr Ile 
    1220                 1225                 1230             


Leu Lys  Tyr Phe Lys Asp Arg  Asp Tyr Lys Phe Asn  Asn Leu Lys 
    1235                 1240                 1245             


Ile Asn  Arg Val Glu Val Tyr  Glu Tyr Asp His Asn  Cys Ala Ala 
    1250                 1255                 1260             


Val Arg  Lys Ser Ile Gly Asp  Asp Leu Thr Ile Lys  Gln Ile Glu 
    1265                 1270                 1275             


Arg Ile  Thr Asp Glu Ser Ile  Arg Lys Ile Leu Met  Asn His Leu 
    1280                 1285                 1290             


Ser Asn  Tyr Asp Asp Asn Leu  Lys Glu Ala Phe Ser  Pro Glu Gly 
    1295                 1300                 1305             


Leu Met  Glu Met Asn Lys Asn  Ile Lys Glu Leu Asn  Gly Gly Lys 
    1310                 1315                 1320             


Asn His  Gln Pro Ile Tyr Lys  Val Arg Leu Phe Glu  Asp Leu Gly 
    1325                 1330                 1335             


Ser Lys  Phe Pro Leu Gly Val  Ser His Asn Asn Pro  Asp Lys Tyr 
    1340                 1345                 1350             


Ala Ile  Ala Ala Lys Gly Thr  Asn Leu Phe Phe Gly  Ile Tyr Glu 
    1355                 1360                 1365             


Asp Gln  Glu Gly Lys Arg Met  Phe Asp Ser Ile Pro  Leu Asn Ile 
    1370                 1375                 1380             


Val Ile  Asp Arg Leu Lys Glu  Lys Lys Ser Pro Val  Pro Glu Thr 
    1385                 1390                 1395             


Tyr Asn  Glu Ser Lys Leu Lys  Phe His Leu Ser Pro  Asn Asp Leu 
    1400                 1405                 1410             


Val Tyr  Val Pro Thr Asp Glu  Glu Gln Lys Gln Pro  Glu Leu Val 
    1415                 1420                 1425             


Asp Val  Asp His Leu Ser Asp  Glu Gln Lys Gly Arg  Val Tyr Lys 
    1430                 1435                 1440             


Ala Val  Ser Phe Thr Gly Asn  Arg Ala Phe Phe Val  Asn His Arg 
    1445                 1450                 1455             


Val Ser  Lys Val Ile His Asp  Tyr Val Glu Phe Gly  Thr Lys Asn 
    1460                 1465                 1470             


Lys Ile  Glu Asn Asp Asp Asp  Lys Arg Ser Leu Lys  His Ile Cys 
    1475                 1480                 1485             


Trp Lys  Leu Lys Val Asn Arg  Leu Gly Glu Ile Thr  Asp Val Lys 
    1490                 1495                 1500             


Arg 
    


<210> 75
<211> 1504
<212> PRT
<213> Bacteroides dorei


<220>
<223> Bacteroides dorei DSM 17855

<400> 75
Met Lys Asn Ile Val Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Val Asn Gly Ser Val Asn Asp Asp Gly Ser Glu Gln Leu Val 
            20                  25                  30          


Lys Ile Gln Ala Ser Gly Ser Arg Ile Ile Pro Met Asp Ala Ala Met 
        35                  40                  45              


Ile Gly Asp Phe Asn Lys Gly Asn Ser Ile Ser Gln Thr Ala Glu Arg 
    50                  55                  60                  


Thr Arg Leu Arg Gly Val Arg Arg Leu Ser Glu Arg Tyr Leu Leu Arg 
65                  70                  75                  80  


Arg Glu Arg Leu His Arg Ile Leu Asp Ile Leu Gly Phe Leu Pro Phe 
                85                  90                  95      


His Phe Ala Gln Asp Leu Asp Arg His Gly Lys Ile Val Lys Gly Lys 
            100                 105                 110         


Glu Pro Lys Leu Ala Trp Arg Lys Asn Glu Ala Gly Gln Phe Glu Phe 
        115                 120                 125             


Ile Phe Gln Asp Ser Phe Lys Glu Met Leu Glu Asp Phe Lys Leu Asn 
    130                 135                 140                 


Tyr Pro Asn Leu Ile Thr Asp Asp Lys Lys Val Pro Tyr Asp Trp Thr 
145                 150                 155                 160 


Ile Tyr Tyr Leu Arg Lys Lys Gly Leu Thr Ser Lys Ile Ser Lys Glu 
                165                 170                 175     


Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr 
            180                 185                 190         


Gln Leu Arg Gly Glu Glu Glu Glu Glu Asn Lys Asp Lys Leu Val Glu 
        195                 200                 205             


Phe Tyr Ala Leu Lys Val Val Ala Val Glu Asp Ser Gly Glu Lys Lys 
    210                 215                 220                 


Gly Lys Asp Ile Trp Tyr Asn Val His Leu Glu Asn Gly Trp Val Tyr 
225                 230                 235                 240 


Arg Arg Thr Ser Asn Met Ser Leu Asp Trp Val Gly Lys Thr Lys Glu 
                245                 250                 255     


Phe Ile Val Thr Thr Asp Leu Glu Lys Asp Gly Thr Pro Lys Lys Asp 
            260                 265                 270         


Lys Glu Gly Asn Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp Asp 
        275                 280                 285             


Trp Ser Leu Val Lys Lys Lys Thr Glu Ala Asp Ile Asp Gln Thr His 
    290                 295                 300                 


Lys Thr Val Gly Ala Tyr Ile Tyr Asp Thr Leu Leu Gly Asn Pro Ser 
305                 310                 315                 320 


Gln Lys Ile Arg Gly Arg Leu Val Arg Thr Ile Glu Arg Lys Tyr Tyr 
                325                 330                 335     


Lys Glu Glu Leu Lys Leu Ile Leu Glu Lys Gln Lys Glu Phe His Leu 
            340                 345                 350         


Glu Leu Gln Asp Arg Ala Leu Tyr Ala Ala Cys Ile Glu Glu Leu Tyr 
        355                 360                 365             


Pro Ile Asn Glu Ala His Arg Asn Asn Val Gly Asn Arg Asp Phe Thr 
    370                 375                 380                 


Tyr Leu Phe Leu Glu Asp Ile Leu Phe Tyr Gln Arg Pro Leu Lys Ser 
385                 390                 395                 400 


Lys Lys Ser Leu Ile Asp Asn Cys Pro Tyr Glu Glu Asn Gln Gly Leu 
                405                 410                 415     


Asp Lys Glu Thr Gly Glu Ile Lys Ser Phe Pro Val Lys Cys Ile Ala 
            420                 425                 430         


Lys Ser His Pro Leu Phe Gln Glu Phe Arg Leu Trp Gln Phe Ile Ile 
        435                 440                 445             


Asn Leu Arg Ile Tyr Arg Lys Asp Leu Ala Gln Asp Val Asp Val Thr 
    450                 455                 460                 


Asn Glu Leu Leu Lys Thr Glu Glu Asp Tyr Val Ala Leu Phe Asp Trp 
465                 470                 475                 480 


Leu Asn Gly Lys Lys Glu Ile Asp Gln Lys Ala Phe Leu Lys Tyr Pro 
                485                 490                 495     


Val Phe Gly Leu Lys Lys Glu Ile Glu Asn Tyr Arg Trp Asn Tyr Val 
            500                 505                 510         


Gln Asp Lys Pro Tyr Pro Cys Asn Glu Thr Arg Ser Leu Met Leu Ala 
        515                 520                 525             


Arg Leu Glu Lys Cys Asp Ile Ser Ile Glu Phe Leu Thr Lys Glu Asn 
    530                 535                 540                 


Glu Glu Ala Leu Trp His Ile Leu Tyr Ser Val Glu Asp Lys Asn Glu 
545                 550                 555                 560 


Ile Val Lys Ala Leu Gln Lys Phe Ala Asp Lys His Asp Leu Asn Ala 
                565                 570                 575     


Ser Phe Val Asp Val Phe Gln Lys Phe Pro Pro Phe Lys Lys Glu Tyr 
            580                 585                 590         


Gly Ser Tyr Ser Ala Lys Ala Ile Lys Lys Leu Leu Pro Leu Met Arg 
        595                 600                 605             


Met Gly Lys Tyr Trp Ser Glu Asn Ser Ile Asp Lys Gly Thr Arg Glu 
    610                 615                 620                 


Arg Ile Asp Lys Ile Ile Thr Gly Glu Tyr Asp Glu Lys Ile Glu Asn 
625                 630                 635                 640 


Arg Val Arg Glu Lys Ala Ile His Leu Ala Asp Val Ser Asp Phe Lys 
                645                 650                 655     


Gly Leu Pro Leu Trp Leu Val Cys Tyr Ile Val Tyr Gly Arg His Ser 
            660                 665                 670         


Glu Ala Lys Glu Ile Ile Gln Trp Lys Ser Pro Ala Asp Ile Asp Ser 
        675                 680                 685             


Tyr Leu Arg Ser Phe Lys Gln His Ser Leu Arg Asn Pro Ile Val Glu 
    690                 695                 700                 


Gln Ile Ile Ile Glu Thr Leu Arg Val Val Arg Asp Ile Trp Lys Gln 
705                 710                 715                 720 


Val Gly Asn Ile Asp Glu Ile His Val Glu Leu Gly Arg Glu Met Lys 
                725                 730                 735     


Asn Pro Ala Asp Lys Arg Lys Lys Met Thr Gln Gln Met Ser Glu Asn 
            740                 745                 750         


Glu Asn Thr Asn Leu Arg Ile Lys Tyr Leu Leu Thr Glu Phe Leu Asn 
        755                 760                 765             


Pro Glu Tyr Glu Val Glu Asn Val Arg Pro Tyr Ser Pro Ser Gln Gln 
    770                 775                 780                 


Asp Ile Leu Arg Ile Tyr Glu Glu Gly Val Leu Asn Ser Val Ser Asp 
785                 790                 795                 800 


Leu Pro Glu Glu Ile Ser Asp Ile Leu Lys Lys Phe Thr Glu Thr Asp 
                805                 810                 815     


Leu Lys Lys Arg Pro Ser Arg Ser Glu Val Leu Arg Tyr Lys Leu Trp 
            820                 825                 830         


Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Glu Val Ile Pro Leu 
        835                 840                 845             


Gly Lys Leu Phe Thr Pro Ala Tyr Glu Ile Glu His Val Ile Pro Gln 
    850                 855                 860                 


Ser Tyr Tyr Phe Asp Asp Ser Phe Ser Asn Lys Val Ile Cys Glu Ala 
865                 870                 875                 880 


Glu Val Asn Lys Leu Lys Ser Asn Leu Leu Gly His Glu Phe Ile Val 
                885                 890                 895     


Lys His His Gly Glu Ile Val Glu Leu Pro Phe Gly Lys Lys Val Arg 
            900                 905                 910         


Ile Phe Thr Val Asp Glu Tyr Glu Gln Phe Val Lys Asp Asn Tyr Ser 
        915                 920                 925             


Arg Thr Arg Ser Lys Met Lys Lys Leu Leu Met Asp Asp Ile Pro Glu 
    930                 935                 940                 


Glu Phe Val Thr Arg Gln Leu Asn Asp Ser Arg Tyr Ile Ser Lys Val 
945                 950                 955                 960 


Val Lys Ser Leu Leu Ser Asn Ile Val Arg Glu Lys Gly Glu Glu Glu 
                965                 970                 975     


Ala Ile Ser Lys Asn Val Ile Pro Cys Thr Gly Gly Val Thr Asp Arg 
            980                 985                 990         


Leu Lys Lys Asp Trp Gly Ile Asn  Glu Val Trp Asn Lys  Ile Ile Leu 
        995                 1000                 1005             


Pro Arg  Phe Gln Arg Leu Asn  Glu Leu Thr Gly Thr  Asn Lys Phe 
    1010                 1015                 1020             


Thr Thr  Lys Asn Val Gly Ile  Gln Glu Ile Pro Thr  Met Pro Leu 
    1025                 1030                 1035             


Glu Leu  Gln Lys Gly Phe Asn  Lys Lys Arg Ile Asp  His Arg His 
    1040                 1045                 1050             


His Ala  Met Asp Ala Ile Ile  Ile Ala Cys Ala Asn  Arg Asn Ile 
    1055                 1060                 1065             


Ile Asn  Tyr Leu Asn Asn Lys  Ser Ala Thr Ala Lys  Ala Glu Leu 
    1070                 1075                 1080             


Ser Arg  Tyr Asp Leu Gln Lys  Met Leu Cys Asp Lys  Ala Lys Thr 
    1085                 1090                 1095             


Asp Asn  Asn Gly Asn Tyr Lys  Trp Val Ile Arg Lys  Pro Trp Ala 
    1100                 1105                 1110             


Ser Phe  Thr Gln Asp Thr Tyr  Leu Ala Leu Glu Asn  Ile Ile Val 
    1115                 1120                 1125             


Ser Phe  Lys Gln Asn Leu Arg  Val Ile Asn Lys Ala  Thr Asn Arg 
    1130                 1135                 1140             


Phe Leu  His Tyr Asn Glu Glu  Gly Lys Lys Ile Phe  Val Lys Gln 
    1145                 1150                 1155             


Gly Lys  Gly Asp Asn Trp Ala  Ile Arg Lys Ser Met  His Lys Asp 
    1160                 1165                 1170             


Thr Val  Phe Gly Glu Val Asn  Leu Arg Arg Ile Lys  Thr Val Ala 
    1175                 1180                 1185             


Leu Asn  Glu Ala Met Lys Asn  Pro Gln Ser Ile Val  Val Lys Asp 
    1190                 1195                 1200             


Phe Lys  Arg Lys Leu Leu Glu  Leu Trp Asn Leu Gly  Phe Asp Ala 
    1205                 1210                 1215             


Lys Arg  Ile Lys Lys Tyr Phe  Glu Asp Asn Arg Glu  Thr Trp Ser 
    1220                 1225                 1230             


Asp Ile  Asn Leu Ser Lys Ile  Glu Val Tyr Tyr Phe  Ser Lys Asp 
    1235                 1240                 1245             


Thr Lys  Asp Arg Phe Phe Ala  Thr Arg Lys Pro Leu  Asp Thr Ser 
    1250                 1255                 1260             


Phe Asp  Arg Lys Lys Ile Glu  Asn Asn Ile Thr Asp  Thr Gly Ile 
    1265                 1270                 1275             


Gln Lys  Ile Leu Leu Arg His  Leu Glu Leu Lys Asp  Asn Asn Pro 
    1280                 1285                 1290             


Asp Ile  Ala Phe Ser Pro Asp  Gly Ile Asp Glu Met  Asn Arg Asn 
    1295                 1300                 1305             


Ile Ile  Gln Leu Asn Asn Gly  Lys Tyr His Gln Pro  Ile Ile Lys 
    1310                 1315                 1320             


Ile Arg  Trp Tyr Glu Gln Ala  Asp Lys Phe Ala Val  Gly Gln Thr 
    1325                 1330                 1335             


Gly Asn  Lys Ser Ser Lys Phe  Val Glu Ala Ala Lys  Gly Thr Asn 
    1340                 1345                 1350             


Leu Phe  Phe Ala Val Tyr Glu  Ser Asn Ile Leu Asp  Lys Lys Thr 
    1355                 1360                 1365             


Asn Thr  Ile Ile Lys Lys Arg  Asn Tyr Ala Thr Ile  Pro Leu Asn 
    1370                 1375                 1380             


Val Ala  Ile Glu Arg Gln Lys  Gln Gly Leu Pro Val  Ala Pro Glu 
    1385                 1390                 1395             


Asp Glu  Asn Gly Asn Asp Pro  Ile Phe Val Leu Ser  Pro Asn Asp 
    1400                 1405                 1410             


Leu Val  Tyr Leu Pro Thr Asp  Asp Glu Leu Ala Asn  Gly Ile Ile 
    1415                 1420                 1425             


Ala Gln  Pro Leu Asp Arg Gly  Arg Ile Tyr Lys Met  Val Ser Ser 
    1430                 1435                 1440             


Ser Gly  Glu Gln Cys Phe Phe  Ile Lys His Ile Val  Ala Asn Val 
    1445                 1450                 1455             


Leu Val  Asp Lys Phe Glu Phe  Ser Pro Leu Asn Lys  Met Glu Arg 
    1460                 1465                 1470             


Ala Leu  Thr Gly Glu Met Ile  Lys Met Ile Cys Ile  Pro Ile Lys 
    1475                 1480                 1485             


Val Asp  Arg Leu Gly Asn Val  Leu Glu Ser Ser Ser  Ser Tyr Lys 
    1490                 1495                 1500             


Lys 
    


<210> 76
<211> 1509
<212> PRT
<213> Bacteroides eggerthii


<220>
<223> Bacteroides eggerthii 1_2_48FAA

<400> 76
Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Ser Val Ile Lys Glu Gln Ala Glu Arg Ile Trp Ile 
            20                  25                  30          


Glu Met Ala Gly Ser Arg Ile Ile Pro Met Asp Ala Ala Val Leu Gly 
        35                  40                  45              


Asp Phe Asp Lys Gly Asn Ser Ile Ser Gln Thr Ser Glu Arg Thr Arg 
    50                  55                  60                  


Leu Arg Gly Ala Arg Arg Leu Arg Glu Arg Gln Leu Leu Arg Arg Glu 
65                  70                  75                  80  


Arg Leu His Lys Val Leu Asn Ile Leu Gly Phe Leu Pro Asn His Tyr 
                85                  90                  95      


Leu Glu Tyr Ile Asp Phe Glu Lys His Pro Gly Lys Phe Leu Ala Asp 
            100                 105                 110         


Ala Glu Pro Lys Leu Ala Trp Val Lys Asp Glu Gln Gly Lys Tyr Thr 
        115                 120                 125             


Phe Leu Phe Gln Ala Ala Phe Asp Glu Met Leu Ala Asp Phe Ala Ile 
    130                 135                 140                 


His Gln Pro Ser Leu Val Ser Gly Asp Lys Lys Ile Pro Tyr Asp Trp 
145                 150                 155                 160 


Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Glu Met Ile Ser Lys 
                165                 170                 175     


Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr 
            180                 185                 190         


Tyr Gln Leu Arg Gly Glu Glu Glu Glu Asp Asn Ala Gly Lys Ser Val 
        195                 200                 205             


Glu Phe Tyr Ala Leu Lys Val Leu Thr Val Glu Ala Thr Asp Glu Lys 
    210                 215                 220                 


Lys Gly Arg Asp Val Trp Tyr Asn Val His Leu Glu Asn Gly Trp Ile 
225                 230                 235                 240 


Tyr Arg Arg Ser Ser Ser Val Pro Leu Asp Trp Glu Gly Gln Val Lys 
                245                 250                 255     


Glu Phe Ile Val Thr Thr Asp Leu Asn Pro Asp Gly Thr Pro Lys Leu 
            260                 265                 270         


Asp Lys Tyr Gly Glu Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp 
        275                 280                 285             


Asp Trp Met Leu Ile Lys Lys Arg Thr Glu Ala Asp Ile Ala Asn Thr 
    290                 295                 300                 


His Lys Thr Val Gly Ala Tyr Ile Tyr Asp Thr Leu Leu Gln Lys Pro 
305                 310                 315                 320 


Gln Gln Lys Ile Ile Gly Lys Leu Val Lys Thr Val Glu Arg Lys Leu 
                325                 330                 335     


Tyr Arg Asp Glu Leu Ser Leu Ile Leu Gln Lys Gln Cys Ala Phe His 
            340                 345                 350         


Ala Glu Leu Gln Asp Arg Ala Leu Tyr Ala Arg Cys Val Glu Ala Leu 
        355                 360                 365             


Tyr Pro Ser Asn Glu Val Arg Arg Lys Asn Ile Ala Asn Arg Asp Phe 
    370                 375                 380                 


Val Tyr Leu Leu Met Asp Asp Ile Leu Phe Tyr Gln Arg Pro Leu Lys 
385                 390                 395                 400 


Thr Lys Lys Ser Leu Ile Ala Asn Cys Pro Tyr Glu Glu Asn Glu Tyr 
                405                 410                 415     


Val Asp Arg Glu Thr Gly Glu Ile Lys Lys Thr Pro Leu Lys Cys Ile 
            420                 425                 430         


Ala Lys Ser His Pro Leu Phe Gln Glu Phe Arg Leu Trp Asn Phe Leu 
        435                 440                 445             


Ser Asn Ile Arg Ile Tyr Gln Lys Glu Lys Glu Ile Asn Gly Thr Leu 
    450                 455                 460                 


His Leu Asp Val Asp Val Thr Ala Glu Phe Leu Lys Thr Glu Asp Asp 
465                 470                 475                 480 


Tyr Val Ala Leu Phe Asp Trp Leu Asn Ser Arg Lys Glu Ile Glu Gln 
                485                 490                 495     


Lys Thr Phe Leu Lys Tyr Pro Lys Phe Gly Leu Lys Lys Glu Ile Ser 
            500                 505                 510         


Asn Tyr Arg Trp Asn Tyr Val Glu Asp Lys Gln Tyr Pro Cys Asn Glu 
        515                 520                 525             


Thr Arg His Ala Ile Leu Ser Ser Leu Glu Lys Ala Asn Val Cys Ile 
    530                 535                 540                 


Asp Phe Leu Ser Asn Glu Lys Glu Val Ala Leu Trp His Ile Leu Tyr 
545                 550                 555                 560 


Ser Val Ser Asp Lys Gln Glu Ile Glu Lys Ala Leu Arg Thr Phe Ala 
                565                 570                 575     


Ala Lys Asn Gly Leu Asp Glu Ser Phe Val Glu Ala Phe Lys Lys Phe 
            580                 585                 590         


Pro Pro Phe Lys Ser Glu Tyr Gly Ala Tyr Ser Ala Lys Ala Ile Lys 
        595                 600                 605             


Lys Met Leu Pro Leu Met Arg Cys Gly Lys Tyr Trp Asp Val Ser Ser 
    610                 615                 620                 


Ile Asp Asp Thr Thr Lys Glu Arg Ile Lys Lys Ile Val Thr Gly Glu 
625                 630                 635                 640 


Tyr Asp Glu Arg Ile Ser Val Lys Val Arg Asp Lys Val Met Asn Leu 
                645                 650                 655     


Ser Asp Ile Ser Cys Phe Arg Arg Leu Pro Leu Trp Leu Ala Cys Tyr 
            660                 665                 670         


Ile Val Tyr Asn Arg His Ser Glu Asp Lys Glu Ala Val Lys Trp Glu 
        675                 680                 685             


Ser Pro Ala Asp Ile Asp Ala Tyr Leu Ala Ser Phe Lys Gln His Ser 
    690                 695                 700                 


Leu Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val 
705                 710                 715                 720 


Val Arg Asp Ile Trp Lys Gln Val Gly Arg Ile Asp Glu Ile His Ile 
                725                 730                 735     


Glu Leu Gly Arg Glu Met Lys Asn Pro Ala Asp Lys Arg Lys Arg Met 
            740                 745                 750         


Thr Ala Gln Ile Leu Glu Asn Glu Asn Ala Asn Leu Arg Ile Lys Ala 
        755                 760                 765             


Leu Leu Ala Glu Phe Met Asn Pro Glu Tyr Glu Ile Glu Asn Val Arg 
    770                 775                 780                 


Pro Tyr Ser Pro Ser Gln Gln Glu Ile Leu Arg Ile Tyr Glu Asp Thr 
785                 790                 795                 800 


Val Leu His Ala Glu Asp Gln Leu Pro Glu Glu Ile Asp Ala Ile Leu 
                805                 810                 815     


Lys Lys Phe Asn Ser Ser Lys Val Pro Thr Lys Ser Glu Phe Leu Arg 
            820                 825                 830         


Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Glu 
        835                 840                 845             


Leu Ile Pro Leu Gly Lys Leu Phe Thr Ala Ala Tyr Glu Ile Glu His 
    850                 855                 860                 


Val Ile Pro Gln Ser Arg Tyr Phe Asp Asp Ser Phe Ser Asn Lys Val 
865                 870                 875                 880 


Ile Cys Glu Ser Ala Val Asn Lys Leu Lys Asp Asn Gln Leu Gly Tyr 
                885                 890                 895     


Glu Phe Ile Lys Asn His His Gly Gln Lys Val Glu Val Gly Phe Gly 
            900                 905                 910         


Lys Ser Val Glu Ile Phe Ser Val Asp Ser Tyr Glu Arg Phe Val Lys 
        915                 920                 925             


Glu Gln Tyr Ala Lys Ser Ala Val Lys Met Lys Lys Leu Leu Met Asp 
    930                 935                 940                 


Asp Ile Pro Glu Gln Phe Ile Glu Arg Gln Leu Asn Asp Ser Arg Tyr 
945                 950                 955                 960 


Ile Ser Lys Val Ile Lys Gly Leu Leu Ser Asn Ile Val Arg Glu Lys 
                965                 970                 975     


Asn Asp Ser Gly Glu Tyr Glu Pro Glu Ala Val Ser Lys Asn Ile Val 
            980                 985                 990         


Val Cys Thr Gly Ser Val Thr Asp  Arg Leu Lys Arg Asp  Trp Gly Met 
        995                 1000                 1005             


Asn Asp  Val Trp Asn Ser Ile  Val Tyr Pro Arg Phe  Glu Arg Leu 
    1010                 1015                 1020             


Asn Ser  Leu Thr Asp Thr Gln  Ser Phe Gly His Trp  Glu Asn Lys 
    1025                 1030                 1035             


Ser Gly  Lys Lys Val Phe Gln  Thr Glu Leu Pro Leu  Glu Tyr Gln 
    1040                 1045                 1050             


Lys Gly  Phe Ser Lys Lys Arg  Ile Asp His Arg His  His Ala Met 
    1055                 1060                 1065             


Asp Ala  Ile Val Ile Ala Cys  Ala Thr Arg Asn His  Val Asn Tyr 
    1070                 1075                 1080             


Leu Ser  Asn Glu Ser Ala Ser  Arg Asn Ala Lys Ile  Ser Arg Tyr 
    1085                 1090                 1095             


Asp Leu  Gln Arg Leu Leu Cys  Asp Lys Asn Arg Thr  Asp Asp Asn 
    1100                 1105                 1110             


Gly Asn  Tyr Lys Trp Val Ile  Lys Lys Pro Trp Asp  Thr Phe Thr 
    1115                 1120                 1125             


Gln Asp  Ala Arg Glu Val Leu  Ser Lys Ile Val Val  Ser Leu Lys 
    1130                 1135                 1140             


Gln Asn  Leu Arg Ile Ile Asn  Lys Thr Thr Asn Val  Tyr Arg His 
    1145                 1150                 1155             


Leu Asp  Ala Thr Gly Asn Arg  Val Tyr Glu Lys Gln  Lys Thr Gly 
    1160                 1165                 1170             


Asp Ser  Trp Ala Ile Arg Lys  Pro Met His Lys Asp  Thr Val Phe 
    1175                 1180                 1185             


Gly Ala  Val Asn Leu Arg Lys  Val Lys Val Val Arg  Leu Ser Val 
    1190                 1195                 1200             


Ala Leu  Asp Thr Pro Ala Met  Ile Val Asp Lys Arg  Val Lys Asn 
    1205                 1210                 1215             


Lys Val  Phe Glu Leu Leu Ser  Tyr Lys Tyr Asp Lys  Lys Arg Ile 
    1220                 1225                 1230             


Glu Lys  Tyr Phe Lys Glu Asn  Ala Phe Leu Trp Lys  Glu Leu Asp 
    1235                 1240                 1245             


Leu Ala  Lys Val Ala Val Tyr  Tyr Phe Thr Glu Ala  Thr Thr Glu 
    1250                 1255                 1260             


Pro Leu  Val Ala Val Arg Lys  Pro Leu Asp Ser Thr  Phe Asn Glu 
    1265                 1270                 1275             


Lys Lys  Ile Lys Glu Ser Val  Thr Asp Thr Gly Ile  Gln Lys Ile 
    1280                 1285                 1290             


Leu Leu  Asn His Leu Cys Thr  Lys Glu Gly Lys Pro  Asp Leu Ala 
    1295                 1300                 1305             


Phe Ser  Ala Glu Gly Ile Glu  Glu Met Asn Arg Asn  Leu Leu Gln 
    1310                 1315                 1320             


Leu Asn  Asn Gly Lys Ser His  Gln Pro Ile Tyr Lys  Val Arg Val 
    1325                 1330                 1335             


Tyr Glu  Pro Arg Gly Asn Lys  Phe Ser Val Gly Val  Leu Gly Asn 
    1340                 1345                 1350             


Lys Gly  Thr Lys Trp Val Glu  Ala Ala Lys Gly Thr  Asn Leu Phe 
    1355                 1360                 1365             


Phe Ala  Ile Tyr Ile Thr Glu  Asp Gly Lys Arg Thr  Tyr Glu Thr 
    1370                 1375                 1380             


Ile Pro  Leu Asn Val Val Ile  Glu Arg Glu Lys Gln  Gly Leu Val 
    1385                 1390                 1395             


Pro Val  Pro Asp Arg Asn Lys  Lys Gly Asp Lys Leu  Leu Phe Trp 
    1400                 1405                 1410             


Leu Ser  Pro Asn Asp Leu Val  Tyr Leu Pro Thr Glu  Glu Glu Arg 
    1415                 1420                 1425             


Glu Phe  Gly Arg Ile Asn Glu  Pro Ile Asp Arg Gly  Arg Ile Tyr 
    1430                 1435                 1440             


Lys Met  Val Ser Cys Thr Gly  Asn Glu Gly His Phe  Ile Pro Ala 
    1445                 1450                 1455             


Asn Val  Ala Asn Pro Ile Val  Pro Val Ile Glu Leu  Gly Ser Asn 
    1460                 1465                 1470             


Asn Lys  Ala Gln Arg Ala Trp  Thr Asn Glu Met Ile  Lys Asp Ile 
    1475                 1480                 1485             


Cys Ile  Pro Ile Lys Val Asp  Arg Leu Gly His Ile  Ile Glu Val 
    1490                 1495                 1500             


Lys Tyr  Arg Ile Asp Glu 
    1505                 


<210> 77
<211> 1526
<212> PRT
<213> Bacteroides faecis


<220>
<223> Bacteroides faecis MAJ27

<400> 77
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Leu Asn Ala Ala Asp Asp Asn Ser Leu Lys Tyr Ile Glu Ala 
            20                  25                  30          


Ala Gly Ser Arg Ile Ile Pro Met Asp Ala Ala Ile Leu Gly Asp Phe 
        35                  40                  45              


Asp Arg Gly Asn Ser Ile Ser Gln Thr Ala Glu Arg Thr Arg Ile Arg 
    50                  55                  60                  


Gly Met Arg His Leu Arg Glu Arg Tyr Leu Leu Arg Arg Ala Arg Leu 
65                  70                  75                  80  


His Arg Ile Leu Asn Leu Leu Gly Phe Leu Pro Phe His Tyr Ala Gln 
                85                  90                  95      


Asp Ile Asp Arg Tyr Gly Asn Phe Ser Ala Asp Met Glu Pro Lys Ile 
            100                 105                 110         


Ala Trp Cys Lys Asn Leu Glu Gly Glu Leu Glu Phe Ile Phe Ile Glu 
        115                 120                 125             


Ser Phe Asn Glu Met Leu Glu Asp Phe Arg Lys Asn Gln Pro Glu Leu 
    130                 135                 140                 


Val Ala Asp Asn Lys Lys Val Pro Tyr Asp Trp Val Ile Tyr Tyr Leu 
145                 150                 155                 160 


Arg Lys Lys Ala Leu Glu Lys Lys Ile Ser Lys Glu Glu Leu Ala Trp 
                165                 170                 175     


Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg Gly 
            180                 185                 190         


Glu Asp Asp Asp Glu Ser Met Lys Thr Ala Lys Thr Arg Gln Tyr Phe 
        195                 200                 205             


Asp Lys Gln Ile Ile Lys Asn Ile Ile Asp Thr Asn Gln Thr Tyr Lys 
    210                 215                 220                 


Gly Gln Arg Ile Leu Ile Val Glu Leu Gln Asn Gly Asp Lys Gly Lys 
225                 230                 235                 240 


Ile Phe Lys Lys Glu Ile Pro Asp Trp Ile Gly Gln Glu Lys Asn Ile 
                245                 250                 255     


Ile Val Thr Val Asp Ile Asp Lys Asp Gly Asn Asp Lys Tyr Glu Glu 
            260                 265                 270         


Ser Gly Ser Leu Ser Cys Arg Phe Lys Ile Pro Thr Asp Ala Glu Trp 
        275                 280                 285             


Glu Ser Glu Trp Lys Leu Ile Lys Met Lys Thr Gln Lys Asp Leu Asp 
    290                 295                 300                 


Glu Ser Asn Lys Thr Val Gly Thr Tyr Ile Tyr Asp Ser Ile Leu Gln 
305                 310                 315                 320 


Asn Pro Thr Gln Lys Val Arg Gly Lys Leu Val Arg Thr Ile Glu Arg 
                325                 330                 335     


Lys Tyr Tyr Lys Ala Glu Leu Lys Gln Ile Leu Glu Lys Gln Thr Glu 
            340                 345                 350         


Phe His Ser Glu Leu Gln Asp Lys Asp Leu Tyr Ile Glu Cys Leu Asn 
        355                 360                 365             


Glu Leu Tyr Ser Asn Asn Asp Thr His Arg Asn Ala Ile Thr Asp Arg 
    370                 375                 380                 


Asp Phe Val Tyr Leu Phe Met Asn Asp Ile Leu Phe Tyr Gln Arg Pro 
385                 390                 395                 400 


Leu Lys Ser Lys Lys Ser Leu Ile Asp Asn Cys Pro Tyr Glu Arg Asn 
                405                 410                 415     


Ile Tyr Ile Asp Lys Glu Thr Gly Glu Ile Lys Tyr Ser Pro Ile Lys 
            420                 425                 430         


Cys Ile Ala Lys Ser His Pro Leu Phe Gln Glu Phe Arg Leu Trp Lys 
        435                 440                 445             


Phe Ile Ser Ser Ile Arg Ile Tyr Gln Arg Glu Ser Val Val Glu Val 
    450                 455                 460                 


Val Asp Lys Gln Leu Asp Leu Phe Ser Ser Gln Ser Thr Ser Val Gln 
465                 470                 475                 480 


Lys Leu Val Thr Asp Val Asp Val Thr Asp Lys Phe Leu Thr Cys Glu 
                485                 490                 495     


Asn Asp Tyr Val Ala Leu Phe Glu Trp Leu Asn Lys Lys Lys Ile Ile 
            500                 505                 510         


Asp Gln Lys Glu Phe Leu Lys Tyr Arg Pro Phe Gly Leu Lys Gly Asp 
        515                 520                 525             


Ile Asp Asn Tyr Arg Trp Asn Tyr Val Glu Asp Lys Ser Tyr Pro Cys 
    530                 535                 540                 


Asn Glu Thr His Ala Met Ile Leu Thr Tyr Phe Ala Lys Ala Gly Ile 
545                 550                 555                 560 


Ser Glu Asp Ile Leu Thr Lys Glu Met Glu Glu Ala Leu Trp His Ile 
                565                 570                 575     


Leu Tyr Ser Val Glu Asp Arg Gln Glu Ile Thr Lys Ala Leu Arg Thr 
            580                 585                 590         


Phe Ala Ser Lys Tyr His Leu Ser Asp Ser Phe Val Lys Val Phe Ser 
        595                 600                 605             


Asn Ile Pro Pro Phe Lys Lys Glu Tyr Gly Ser Tyr Ser Ala Lys Ala 
    610                 615                 620                 


Ile Lys Lys Leu Leu Ser Leu Met Arg Met Gly Lys Tyr Trp Ser Glu 
625                 630                 635                 640 


Asp Ala Ile Asp Val Asn Thr Arg Glu Arg Ile Asp Lys Ile Val Thr 
                645                 650                 655     


Gly Glu Tyr Asp Glu Lys Ile Arg Asp Arg Val Arg Glu Lys Thr Ile 
            660                 665                 670         


Arg Leu Asn Asp Ile Arg His Phe Arg Ala Leu Pro Asp Trp Leu Ala 
        675                 680                 685             


Cys Tyr Val Val Tyr Asp Arg His Ser Glu Thr Arg Glu Ile Thr Glu 
    690                 695                 700                 


Trp Lys Ser Pro Glu Glu Ile Asp Glu Tyr Ile Arg Asn Phe Lys Gln 
705                 710                 715                 720 


His Ser Leu Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu 
                725                 730                 735     


Arg Thr Val Arg Asp Ile Trp Lys Gln Val Gly Cys Ile Asp Glu Ile 
            740                 745                 750         


His Val Glu Leu Gly Arg Glu Met Lys Asn Pro Ala Asp Lys Arg Lys 
        755                 760                 765             


Arg Ile Thr Ser Gln Ile Ile Glu Asn Glu Asn Ala Asn Leu Arg Val 
    770                 775                 780                 


Lys Ala Leu Leu Thr Glu Phe Val Asn Ser Glu Phe Glu Ile Glu Asn 
785                 790                 795                 800 


Val Arg Pro Tyr Ser Leu Ser Gln Gln Asp Ile Leu Arg Ile Tyr Glu 
                805                 810                 815     


Asp Gly Val Leu Asn Ser Val Ala Glu Val Pro Gly Asp Ile Ala Gly 
            820                 825                 830         


Ile Leu Lys Lys Phe Asn Glu Asn Asp Ala Lys Lys Arg Pro Thr Thr 
        835                 840                 845             


Ser Glu Ile Leu Arg Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Arg Ser 
    850                 855                 860                 


Pro Tyr Thr Gly Glu Met Ile Pro Leu Ser Lys Leu Phe Thr Ser Ala 
865                 870                 875                 880 


Tyr Glu Ile Glu His Val Ile Pro Gln Ser Arg Tyr Phe Asp Asp Ser 
                885                 890                 895     


Phe Ser Asn Lys Val Ile Cys Glu Ala Glu Val Asn Lys Leu Lys Asp 
            900                 905                 910         


Asn Ala Leu Gly Tyr Glu Phe Ile Lys Lys His His Gly Glu Lys Val 
        915                 920                 925             


Glu Leu Gly Phe Gly Lys Ile Val Glu Ile Phe Ser Val Ser Val Tyr 
    930                 935                 940                 


Glu Gln Phe Val Lys Asp Asn Tyr Ser Arg Asn Arg Gly Lys Met Lys 
945                 950                 955                 960 


Lys Leu Leu Met Asp Glu Ile Pro Glu Gln Phe Ile Glu Arg Gln Leu 
                965                 970                 975     


Asn Asp Ser Arg Tyr Ile Ser Lys Val Val Lys Thr Leu Leu Ser Asn 
            980                 985                 990         


Val Val Arg Glu Lys Ala Glu Gln  Glu Ala Val Ser Lys  Asn Val Ile 
        995                 1000                 1005             


Val Cys  Thr Gly Gly Val Thr  Asp Arg Leu Lys Lys  Asp Trp Gly 
    1010                 1015                 1020             


Ile Asn  Asp Val Trp Asn Lys  Ile Val Leu Pro Arg  Phe Leu Arg 
    1025                 1030                 1035             


Leu Asn  Glu Leu Thr Asn Ser  Thr Asn Phe Thr Ala  Lys Asn Ala 
    1040                 1045                 1050             


Ala Gly  Asn Glu Ile Pro Ala  Met Pro Leu Glu Leu  Gln Lys Gly 
    1055                 1060                 1065             


Phe Asn  Lys Lys Arg Ile Asp  His Arg His His Ala  Met Asp Ala 
    1070                 1075                 1080             


Ile Val  Ile Ala Cys Ala Asn  Arg Asn Ile Val Asn  Tyr Leu Asn 
    1085                 1090                 1095             


Asn Glu  Ser Ala Ser Arg Lys  Ala Lys Ile Ser Arg  His Asp Leu 
    1100                 1105                 1110             


Gln Ala  Ile Leu Cys Asp Lys  Val Arg Thr Asp Asp  Lys Gly Asn 
    1115                 1120                 1125             


Tyr Gln  Trp Arg Val Lys Lys  Pro Trp Asp Thr Phe  Thr Gln Asp 
    1130                 1135                 1140             


Val Tyr  Val Ala Leu Glu Asn  Ile Ile Val Ser Phe  Lys Gln Asn 
    1145                 1150                 1155             


Leu Arg  Val Ile Asn Lys Thr  Ser Asn Tyr Tyr Trp  His Tyr Glu 
    1160                 1165                 1170             


Asn Gly  Lys Lys Val Leu Val  Lys Gln Val Lys Gly  Asp Ser Trp 
    1175                 1180                 1185             


Ala Ile  Arg Lys Pro Met His  Lys Asp Thr Val Phe  Gly Glu Val 
    1190                 1195                 1200             


Asn Leu  Arg Lys Val Lys Ser  Val Ser Leu Asn Glu  Ala Leu Lys 
    1205                 1210                 1215             


Asn Pro  Gln Phe Ile Val Glu  Lys Asp Leu Lys Arg  Gln Leu Leu 
    1220                 1225                 1230             


Ser Leu  Leu Gln Gln Asn Phe  Asp Ile Lys Lys Ile  Lys Lys Tyr 
    1235                 1240                 1245             


Phe Glu  Glu His Lys Asp Ile  Trp Ser Asp Ile Ser  Leu Ser Lys 
    1250                 1255                 1260             


Met Asn  Ile Tyr Tyr Phe Thr  Lys Glu Thr Lys Asp  Arg Tyr Phe 
    1265                 1270                 1275             


Ala Thr  Arg Lys Pro Leu Asp  Ala Ser Phe Asp Lys  Lys Lys Ile 
    1280                 1285                 1290             


Glu Ser  Cys Ile Thr Asp Thr  Gly Ile Gln Gln Ile  Leu Leu Arg 
    1295                 1300                 1305             


His Leu  Glu Leu Lys Glu Asn  Asp Pro Glu Arg Ala  Phe Ser Pro 
    1310                 1315                 1320             


Asp Gly  Ile Asp Glu Met Asn  Arg Asn Ile Ile Gln  Leu Asn Lys 
    1325                 1330                 1335             


Gly Lys  Gly His His Pro Ile  Ala Lys Val Arg Val  Tyr Glu Lys 
    1340                 1345                 1350             


Ala Asp  Lys Phe Glu Val Gly  Gln Arg Gly Asn Lys  Ser Ser Lys 
    1355                 1360                 1365             


Phe Val  Glu Ala Ala Lys Gly  Thr Asn Leu Phe Phe  Ala Val Tyr 
    1370                 1375                 1380             


Glu Thr  Glu Tyr Pro Asp Glu  Lys Thr Asn Ser Ile  Val Arg Lys 
    1385                 1390                 1395             


Arg Asn  Tyr Ala Thr Ile Pro  Leu Asn Ile Ala Ile  Glu Arg Gln 
    1400                 1405                 1410             


Lys Arg  Gly Leu Ser Thr Ala  Pro Glu Asp Glu Lys  Gly Asn Val 
    1415                 1420                 1425             


Pro Ser  Phe Val Leu Ser Pro  Asn Asp Leu Val Tyr  Leu Pro Thr 
    1430                 1435                 1440             


Ser Glu  Asp Ile Val Asn Gly  His Ile Thr Gln Pro  Ile Asp Lys 
    1445                 1450                 1455             


Ser Arg  Ile Tyr Lys Met Val  Ser Ser Ser Gly Ser  Gln Cys Phe 
    1460                 1465                 1470             


Phe Ile  Lys His Asn Ile Ala  Asn Ile Ile Val Asp  Lys Tyr Glu 
    1475                 1480                 1485             


Phe Ser  Pro Leu Asn Lys Met  Glu Arg Ala Ile Ser  Asn Glu Met 
    1490                 1495                 1500             


Ile Lys  Glu Ile Cys Ile Pro  Val Lys Val Asp Arg  Leu Gly Asn 
    1505                 1510                 1515             


Ile Val  Lys Leu Gly Lys Ser  Glu 
    1520                 1525     


<210> 78
<211> 1509
<212> PRT
<213> Bacteroides fluxus


<220>
<223> Bacteroides fluxus YIT 12057

<400> 78
Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Ser Val Ile Lys Glu Gln Ala Glu Arg Ile Trp Ile 
            20                  25                  30          


Glu Met Ala Gly Ser Arg Ile Ile Pro Met Asp Ala Ala Val Leu Gly 
        35                  40                  45              


Asp Phe Asp Lys Gly Asn Ser Ile Ser Gln Thr Ser Glu Arg Thr Arg 
    50                  55                  60                  


Leu Arg Gly Val Arg Arg Leu Arg Glu Arg Gln Leu Leu Arg Arg Glu 
65                  70                  75                  80  


Arg Leu His Lys Val Leu Asn Ile Leu Gly Phe Leu Pro Asn His Tyr 
                85                  90                  95      


Leu Glu Tyr Ile Asp Phe Glu Lys His Pro Gly Lys Phe Leu Ser Asp 
            100                 105                 110         


Ala Glu Pro Lys Leu Pro Trp Val Lys Asp Glu Gln Gly Lys Tyr Thr 
        115                 120                 125             


Phe Leu Phe Gln Ala Ala Phe Asp Glu Met Leu Ala Asp Phe Ala Ile 
    130                 135                 140                 


His Gln Pro Ser Leu Val Ser Gly Asp Lys Lys Ile Pro Tyr Asp Trp 
145                 150                 155                 160 


Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Glu Met Ile Ser Lys 
                165                 170                 175     


Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr 
            180                 185                 190         


Tyr Gln Leu Arg Gly Glu Glu Glu Glu Asp Asn Ala Gly Lys Ser Val 
        195                 200                 205             


Glu Phe Tyr Ala Leu Lys Val Leu Thr Val Glu Ala Thr Asp Glu Lys 
    210                 215                 220                 


Lys Gly Arg Asp Val Trp Tyr Asn Val His Leu Glu Asn Gly Trp Ile 
225                 230                 235                 240 


Tyr Arg Arg Ser Ser Ser Val Pro Leu Asp Trp Glu Gly Gln Ile Lys 
                245                 250                 255     


Glu Phe Ile Val Thr Thr Asp Leu Asn Pro Asp Ser Thr Pro Lys Leu 
            260                 265                 270         


Asp Lys Tyr Gly Glu Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp 
        275                 280                 285             


Asp Trp Met Leu Ile Lys Lys Arg Thr Glu Ala Asp Ile Ala Asn Thr 
    290                 295                 300                 


His Lys Thr Val Gly Ala Tyr Ile Tyr Asp Thr Leu Leu Gln Lys Pro 
305                 310                 315                 320 


Gln Gln Lys Ile Ile Gly Lys Leu Val Lys Thr Val Glu Arg Lys Leu 
                325                 330                 335     


Tyr Arg Asp Glu Leu Ser Leu Ile Leu Gln Lys Gln Cys Ala Phe His 
            340                 345                 350         


Ala Glu Leu Gln Asp Arg Thr Leu Tyr Ala Arg Cys Val Glu Ala Leu 
        355                 360                 365             


Tyr Pro Asn Asn Glu Val Gln Arg Arg Asn Ile Ala Asn Arg Asp Phe 
    370                 375                 380                 


Val Tyr Leu Leu Met Asp Asp Val Leu Phe Tyr Gln Arg Pro Leu Lys 
385                 390                 395                 400 


Thr Lys Lys Ser Leu Ile Ala Asn Cys Pro Tyr Glu Glu Asn Glu Tyr 
                405                 410                 415     


Val Asp Arg Glu Thr Gly Glu Ile Lys Lys Ala Pro Leu Lys Cys Ile 
            420                 425                 430         


Ala Lys Ser His Pro Leu Phe Gln Glu Phe Arg Leu Trp Asn Phe Leu 
        435                 440                 445             


Ser Asn Ile Arg Ile Tyr Gln Lys Glu Lys Glu Ile Asn Gly Thr Leu 
    450                 455                 460                 


His Leu Asp Val Asp Val Thr Ala Glu Phe Leu Lys Thr Glu Asp Asp 
465                 470                 475                 480 


Tyr Val Ala Leu Phe Asp Trp Leu Asn Ser Arg Lys Glu Ile Glu Gln 
                485                 490                 495     


Lys Thr Phe Leu Lys Tyr Pro Lys Phe Gly Leu Lys Lys Glu Ile Ser 
            500                 505                 510         


Asn Tyr Arg Trp Asn Tyr Val Glu Asp Lys Gln Tyr Pro Cys Asn Glu 
        515                 520                 525             


Thr Arg His Ala Ile Leu Ser Arg Leu Glu Lys Ala Asn Val Cys Ile 
    530                 535                 540                 


Asp Phe Leu Ser Asn Glu Lys Glu Val Ala Leu Trp His Ile Leu Tyr 
545                 550                 555                 560 


Ser Val Ser Asp Lys Gln Glu Ile Glu Lys Ala Leu Arg Thr Phe Ala 
                565                 570                 575     


Ala Lys Asn Gly Leu Asp Glu Ser Phe Val Glu Ala Phe Lys Lys Phe 
            580                 585                 590         


Pro Pro Phe Lys Ser Glu Tyr Gly Ala Tyr Ser Ala Lys Ala Ile Lys 
        595                 600                 605             


Lys Leu Leu Pro Leu Met Arg Cys Gly Lys Tyr Trp Asp Val Ser Ser 
    610                 615                 620                 


Ile Asp Asp Thr Thr Lys Glu Arg Ile Lys Lys Ile Val Ala Gly Glu 
625                 630                 635                 640 


Tyr Asp Glu Arg Ile Ala Val Lys Val Arg Asp Lys Val Met Asn Leu 
                645                 650                 655     


Ser Asp Ile Ser Cys Phe Lys Arg Leu Pro Leu Trp Leu Ala Cys Tyr 
            660                 665                 670         


Ile Val Tyr Asn Arg His Ser Glu Asp Lys Glu Ala Val Lys Trp Glu 
        675                 680                 685             


Ser Pro Ala Asp Ile Asp Ala Tyr Leu Ala Ser Phe Lys Gln His Ser 
    690                 695                 700                 


Leu Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val 
705                 710                 715                 720 


Val Arg Asp Ile Trp Lys Gln Val Gly Arg Ile Asp Glu Ile His Ile 
                725                 730                 735     


Glu Leu Gly Arg Glu Met Lys Asn Pro Ala Asp Lys Arg Lys Arg Met 
            740                 745                 750         


Thr Ala Gln Ile Leu Glu Asn Glu Asn Ala Asn Leu Arg Ile Lys Ala 
        755                 760                 765             


Leu Leu Ala Glu Phe Met Asn Pro Glu Tyr Glu Ile Glu Asn Val Arg 
    770                 775                 780                 


Pro Tyr Ser Pro Ser Gln Gln Glu Ile Leu Arg Ile Tyr Glu Asp Met 
785                 790                 795                 800 


Val Leu His Ala Glu Asp Gln Leu Pro Glu Glu Ile Asp Ala Ile Leu 
                805                 810                 815     


Lys Lys Phe Asn Ser Ser Lys Val Pro Thr Lys Ser Glu Phe Leu Arg 
            820                 825                 830         


Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Glu 
        835                 840                 845             


Leu Ile Pro Leu Gly Lys Leu Phe Thr Ala Ala Tyr Glu Ile Glu His 
    850                 855                 860                 


Val Ile Pro Gln Ser Arg Tyr Phe Asp Asp Ser Phe Ser Asn Lys Val 
865                 870                 875                 880 


Ile Cys Glu Ser Ala Val Asn Lys Leu Lys Asp Asn Gln Leu Gly Tyr 
                885                 890                 895     


Glu Phe Ile Lys Asn His His Gly Gln Lys Val Glu Val Gly Phe Gly 
            900                 905                 910         


Lys Ser Val Glu Ile Phe Ser Val Asp Ser Tyr Glu Arg Phe Val Lys 
        915                 920                 925             


Glu Gln Tyr Ala Lys Ser Ala Val Lys Met Lys Lys Met Leu Met Asp 
    930                 935                 940                 


Asp Ile Pro Glu Gln Phe Ile Glu Arg Gln Leu Asn Asp Ser Arg Tyr 
945                 950                 955                 960 


Ile Ser Lys Val Ile Lys Gly Leu Leu Ser Asn Ile Val Arg Glu Lys 
                965                 970                 975     


Asn Asp Ser Gly Glu Tyr Glu Pro Glu Ala Val Ser Lys Asn Ile Val 
            980                 985                 990         


Val Cys Thr Gly Ser Val Thr Asp  Arg Leu Lys Arg Asp  Trp Gly Met 
        995                 1000                 1005             


Asn Asp  Val Trp Asn Ser Ile  Val Tyr Pro Arg Phe  Glu Arg Leu 
    1010                 1015                 1020             


Asn Ser  Leu Thr Asp Thr Gln  Ser Phe Gly His Trp  Glu Asn Lys 
    1025                 1030                 1035             


Ser Gly  Lys Lys Val Phe Gln  Thr Glu Leu Pro Leu  Glu Tyr Gln 
    1040                 1045                 1050             


Lys Gly  Phe Ser Lys Lys Arg  Ile Asp His Arg His  His Ala Met 
    1055                 1060                 1065             


Asp Ala  Ile Val Ile Ala Cys  Ala Thr Arg Asn His  Val Asn Tyr 
    1070                 1075                 1080             


Leu Ser  Asn Glu Ser Ala Ser  Arg Asn Ala Lys Ile  Ser Arg Tyr 
    1085                 1090                 1095             


Asp Leu  Gln Arg Leu Leu Cys  Asp Lys Ser Arg Thr  Asp Asp Asn 
    1100                 1105                 1110             


Gly Asn  Tyr Lys Trp Val Ile  Lys Lys Pro Trp Asp  Thr Phe Thr 
    1115                 1120                 1125             


Gln Asp  Ala Arg Glu Val Leu  Ser Lys Ile Val Val  Ser Leu Lys 
    1130                 1135                 1140             


Gln Asn  Leu Arg Ile Ile Asn  Lys Thr Thr Asn Val  Tyr Arg His 
    1145                 1150                 1155             


Leu Asp  Ala Thr Gly Asn Arg  Val Tyr Glu Lys Gln  Lys Thr Gly 
    1160                 1165                 1170             


Asp Ser  Trp Ala Ile Arg Lys  Pro Met His Lys Asp  Thr Val Phe 
    1175                 1180                 1185             


Gly Ala  Val Asn Leu Arg Lys  Val Lys Val Val Arg  Leu Ser Val 
    1190                 1195                 1200             


Ala Leu  Asp Ala Pro Thr Met  Ile Val Asp Lys Arg  Val Lys Asn 
    1205                 1210                 1215             


Lys Val  Phe Glu Leu Leu Ser  Tyr Lys Tyr Asp Lys  Lys Arg Ile 
    1220                 1225                 1230             


Glu Lys  Tyr Phe Lys Glu Asn  Ala Val Leu Trp Lys  Glu Leu Asp 
    1235                 1240                 1245             


Leu Ala  Arg Val Ala Val Tyr  Tyr Phe Thr Glu Ala  Thr Thr Glu 
    1250                 1255                 1260             


Pro Leu  Val Ala Val Arg Lys  Pro Leu Asp Ser Thr  Phe Asn Glu 
    1265                 1270                 1275             


Lys Lys  Ile Lys Glu Ser Val  Thr Asp Thr Gly Ile  Gln Lys Ile 
    1280                 1285                 1290             


Leu Leu  Asn His Leu Cys Thr  Lys Glu Gly Lys Pro  Asp Leu Ala 
    1295                 1300                 1305             


Phe Ser  Ala Glu Gly Ile Glu  Glu Met Asn Arg Asn  Leu Leu Gln 
    1310                 1315                 1320             


Leu Asn  Asn Gly Lys Arg His  Gln Pro Ile Tyr Lys  Val Arg Val 
    1325                 1330                 1335             


Tyr Glu  Pro Arg Gly Asn Lys  Phe Ser Val Gly Val  Leu Gly Asn 
    1340                 1345                 1350             


Lys Gly  Thr Lys Trp Val Glu  Ala Ala Lys Gly Thr  Asn Leu Phe 
    1355                 1360                 1365             


Phe Ala  Ile Tyr Ile Thr Glu  Asp Gly Lys Arg Thr  Tyr Glu Thr 
    1370                 1375                 1380             


Ile Pro  Leu Asn Met Val Ile  Glu Arg Glu Lys Gln  Gly Leu Ala 
    1385                 1390                 1395             


Pro Val  Pro Asp Lys Asn Glu  Lys Gly Asp Lys Leu  Leu Phe Trp 
    1400                 1405                 1410             


Leu Ser  Pro Asn Asp Leu Val  Tyr Leu Pro Thr Glu  Glu Glu Leu 
    1415                 1420                 1425             


Glu Phe  Gly Arg Ile Asn Glu  Pro Ile Asp Arg Gly  Arg Ile Tyr 
    1430                 1435                 1440             


Lys Met  Val Ser Ser Ser Gly  Asn Gln Cys Phe Phe  Ile Pro Gln 
    1445                 1450                 1455             


Ser Ile  Ser Asn Ala Ile Ile  Pro Thr Lys Glu Leu  Gly Ala Asn 
    1460                 1465                 1470             


Asn Lys  Ala Glu Arg Ser Trp  Asp Gly Ala Met Ile  Lys Asn Ile 
    1475                 1480                 1485             


Cys Ile  Pro Val Lys Val Asp  Arg Leu Gly Arg Ile  Ile Glu Val 
    1490                 1495                 1500             


Lys Tyr  Arg Ile Asn Glu 
    1505                 


<210> 79
<211> 1436
<212> PRT
<213> Bacteroides fragilis

<400> 79
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Glu Asn Lys Asp Glu Arg Ser Ser Ile Val 
            20                  25                  30          


Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Leu Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Met Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Glu Thr 
65                  70                  75                  80  


Leu Thr Glu Val Leu Lys Glu His Lys Leu Ile Thr Glu Asp Thr Ile 
                85                  90                  95      


Leu Ser Glu Asn Gly Asn Arg Thr Thr Phe Glu Thr Tyr Arg Leu Arg 
            100                 105                 110         


Ala Lys Ala Val Thr Glu Glu Ile Ser Leu Glu Glu Phe Ala Arg Val 
        115                 120                 125             


Leu Leu Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Gly Val Glu Glu Gly Thr Leu Ile Asp Gly Met Asp Ile Ala Arg 
145                 150                 155                 160 


Glu Leu Tyr Asn Asn Asn Leu Thr Pro Gly Glu Leu Cys Leu Gln Leu 
                165                 170                 175     


Leu Asp Ala Gly Lys Lys Phe Leu Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Asn Glu Leu Asp Arg Ile Trp Glu Lys Gln Lys Glu Tyr Tyr Pro 
        195                 200                 205             


Glu Ile Leu Thr Asp Val Leu Lys Glu Glu Leu Arg Gly Lys Lys Arg 
    210                 215                 220                 


Asp Ala Val Trp Ala Ile Cys Ala Lys Tyr Phe Val Trp Lys Glu Asn 
225                 230                 235                 240 


Tyr Thr Glu Trp Asn Lys Glu Lys Gly Lys Thr Glu Gln Gln Glu Arg 
                245                 250                 255     


Glu His Lys Leu Glu Gly Ile Tyr Ser Lys Arg Lys Arg Asp Glu Ala 
            260                 265                 270         


Lys Arg Glu Asn Leu Gln Trp Arg Val Asn Gly Leu Lys Glu Lys Leu 
        275                 280                 285             


Ser Leu Glu Gln Leu Val Ile Val Phe Gln Glu Met Asn Thr Gln Ile 
    290                 295                 300                 


Asn Asn Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Glu 
305                 310                 315                 320 


Leu Tyr Phe Asn Lys Gln Thr Val Gly Gln Tyr Gln Met Glu Met Leu 
                325                 330                 335     


Asp Lys Asn Pro Asn Ala Ser Leu Arg Asn Met Val Phe Tyr Arg Gln 
            340                 345                 350         


Asp Tyr Leu Asp Glu Phe Asn Met Leu Trp Glu Lys Gln Ala Val Tyr 
        355                 360                 365             


His Lys Glu Leu Thr Glu Glu Leu Lys Lys Glu Ile Arg Asp Ile Ile 
    370                 375                 380                 


Ile Phe Tyr Gln Arg Arg Leu Lys Ser Gln Lys Gly Leu Ile Gly Phe 
385                 390                 395                 400 


Cys Glu Phe Glu Ser Arg Gln Ile Glu Val Asp Ile Asp Gly Lys Lys 
                405                 410                 415     


Lys Ile Lys Thr Val Gly Asn Arg Val Ile Ser Arg Ser Ser Pro Leu 
            420                 425                 430         


Phe Gln Glu Phe Lys Ile Trp Gln Ile Leu Asn Asn Ile Glu Val Thr 
        435                 440                 445             


Val Val Gly Lys Lys Arg Lys Arg Arg Lys Leu Lys Glu Asn Tyr Ser 
    450                 455                 460                 


Ala Leu Phe Glu Glu Leu Asn Asp Ala Glu Gln Leu Glu Leu Asn Gly 
465                 470                 475                 480 


Ser Arg Arg Leu Cys Gln Glu Glu Lys Glu Leu Leu Ala Gln Glu Leu 
                485                 490                 495     


Phe Ile Arg Asp Lys Met Thr Lys Ser Glu Val Leu Lys Leu Leu Phe 
            500                 505                 510         


Asp Asn Pro Gln Glu Leu Asp Leu Asn Phe Lys Thr Ile Asp Gly Asn 
        515                 520                 525             


Lys Thr Gly Tyr Ala Leu Phe Gln Ala Tyr Ser Lys Met Ile Glu Met 
    530                 535                 540                 


Ser Gly His Glu Pro Val Asp Phe Lys Lys Pro Val Glu Lys Val Val 
545                 550                 555                 560 


Glu Tyr Ile Lys Ala Val Phe Asp Leu Leu Asn Trp Asn Thr Asp Ile 
                565                 570                 575     


Leu Gly Phe Asn Ser Asn Glu Glu Leu Asp Asn Gln Ser Tyr Tyr Lys 
            580                 585                 590         


Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Pro Thr Gly 
        595                 600                 605             


Asn Gly Arg Leu Ile Gln Lys Met Thr Glu Leu Tyr Gly Phe Glu Lys 
    610                 615                 620                 


Glu Tyr Ala Thr Ile Leu Ala Asn Val Ser Phe Gln Asp Asp Tyr Gly 
625                 630                 635                 640 


Ser Leu Ser Ala Lys Ala Ile His Lys Ile Leu Pro His Leu Lys Glu 
                645                 650                 655     


Gly Asn Arg Tyr Asp Val Ala Cys Val Tyr Ala Gly Tyr Arg His Ser 
            660                 665                 670         


Glu Ser Ser Leu Thr Arg Glu Glu Ile Ala Asn Lys Val Leu Lys Asp 
        675                 680                 685             


Arg Leu Met Leu Leu Pro Lys Asn Ser Leu His Asn Pro Val Val Glu 
    690                 695                 700                 


Lys Ile Leu Asn Gln Met Val Asn Val Ile Asn Val Ile Ile Asp Ile 
705                 710                 715                 720 


Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 
                725                 730                 735     


Lys Asn Ala Lys Glu Arg Glu Glu Leu Thr Lys Ser Ile Ala Gln Thr 
            740                 745                 750         


Thr Lys Ala His Glu Glu Tyr Lys Thr Leu Leu Gln Thr Glu Phe Gly 
        755                 760                 765             


Leu Thr Asn Val Ser Arg Thr Asp Ile Leu Arg Tyr Lys Leu Tyr Lys 
    770                 775                 780                 


Glu Leu Glu Ser Cys Gly Tyr Lys Thr Leu Tyr Ser Asn Thr Tyr Ile 
785                 790                 795                 800 


Ser Arg Glu Lys Leu Phe Ser Lys Glu Phe Asp Ile Glu His Ile Ile 
                805                 810                 815     


Pro Gln Ala Arg Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Glu 
            820                 825                 830         


Ala Arg Ser Val Asn Ile Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe 
        835                 840                 845             


Val Lys Glu Lys Phe Gly Glu Ser Gly Ala Asp Asn Ser Leu Glu His 
    850                 855                 860                 


Tyr Leu Asn Asn Ile Glu Asp Leu Phe Lys Ser Gly Lys Ile Ser Lys 
865                 870                 875                 880 


Thr Lys Tyr Asn Lys Leu Lys Met Ala Glu Gln Asp Ile Pro Asp Gly 
                885                 890                 895     


Phe Ile Glu Arg Asp Leu Arg Asn Thr Gln Tyr Ile Ala Lys Lys Ala 
            900                 905                 910         


Leu Ser Met Leu Asn Glu Ile Ser His Arg Val Val Ala Thr Ser Gly 
        915                 920                 925             


Ser Val Thr Asp Lys Leu Arg Glu Asp Trp Gln Leu Ile Asp Val Met 
    930                 935                 940                 


Lys Glu Leu Asn Trp Glu Lys Tyr Lys Ala Leu Gly Leu Val Glu Tyr 
945                 950                 955                 960 


Phe Glu Asp Arg Asp Gly Arg Gln Ile Gly Arg Ile Lys Asp Trp Thr 
                965                 970                 975     


Lys Arg Asn Asp His Arg His His Ala Met Asp Ala Leu Thr Val Ala 
            980                 985                 990         


Phe Thr Lys Asp Val Phe Ile Gln  Tyr Phe Asn Asn Lys  Asn Ala Ser 
        995                 1000                 1005             


Leu Asp  Pro Asn Ala Asn Glu  His Ala Ile Lys Asn  Lys Tyr Phe 
    1010                 1015                 1020             


Gln Asn  Gly Arg Ala Ile Ala  Pro Met Pro Leu Arg  Glu Phe Arg 
    1025                 1030                 1035             


Ala Glu  Ala Lys Lys His Leu  Glu Asn Thr Leu Ile  Ser Ile Lys 
    1040                 1045                 1050             


Ala Lys  Asn Lys Val Ile Thr  Gly Asn Ile Asn Lys  Thr Arg Lys 
    1055                 1060                 1065             


Lys Gly  Gly Val Asn Lys Asn  Met Gln Gln Thr Pro  Arg Gly Gln 
    1070                 1075                 1080             


Leu His  Leu Glu Thr Ile Tyr  Gly Ser Gly Lys Gln  Tyr Leu Thr 
    1085                 1090                 1095             


Lys Glu  Glu Lys Val Asn Ala  Ser Phe Asp Met Arg  Lys Ile Gly 
    1100                 1105                 1110             


Thr Val  Ser Lys Leu Ala Tyr  Arg Asp Ala Leu Leu  Lys Arg Leu 
    1115                 1120                 1125             


Tyr Glu  Asn Asp Asn Asp Pro  Lys Lys Ala Phe Ala  Gly Lys Asn 
    1130                 1135                 1140             


Ser Leu  Asp Lys Gln Pro Ile  Trp Leu Asp Lys Glu  Gln Met Arg 
    1145                 1150                 1155             


Lys Val  Pro Glu Lys Val Lys  Ile Val Thr Leu Glu  Ala Ile Tyr 
    1160                 1165                 1170             


Thr Ile  Arg Lys Glu Ile Ser  Pro Asp Leu Lys Val  Asp Lys Val 
    1175                 1180                 1185             


Ile Asp  Val Gly Val Arg Lys  Ile Leu Ile Asp Arg  Leu Asn Glu 
    1190                 1195                 1200             


Tyr Gly  Asn Asp Ala Lys Lys  Ala Phe Ser Asn Leu  Asp Glu Asn 
    1205                 1210                 1215             


Pro Ile  Trp Leu Asn Lys Glu  Lys Gly Ile Ser Ile  Lys Arg Val 
    1220                 1225                 1230             


Thr Ile  Ser Gly Ile Ser Asn  Ala Gln Ser Leu His  Val Lys Lys 
    1235                 1240                 1245             


Asp Lys  Asp Gly Lys Pro Ile  Leu Asp Glu Asn Gly  Arg Asn Ile 
    1250                 1255                 1260             


Pro Val  Asp Phe Val Asn Thr  Gly Asn Asn His His  Val Ala Val 
    1265                 1270                 1275             


Tyr Tyr  Arg Pro Val Ile Asp  Lys Arg Gly Gln Leu  Val Val Asp 
    1280                 1285                 1290             


Glu Ala  Gly Asn Pro Lys Tyr  Glu Leu Glu Glu Val  Val Val Ser 
    1295                 1300                 1305             


Phe Phe  Glu Ala Val Thr Arg  Ala Asn Leu Gly Gln  Pro Ile Ile 
    1310                 1315                 1320             


Asp Lys  Asp Tyr Lys Thr Thr  Glu Gly Trp Gln Phe  Leu Phe Ser 
    1325                 1330                 1335             


Met Lys  Gln Asn Glu Tyr Phe  Val Phe Pro Asn Glu  Lys Thr Gly 
    1340                 1345                 1350             


Phe Asn  Pro Lys Glu Ile Asp  Leu Leu Asp Val Glu  Asn Tyr Gly 
    1355                 1360                 1365             


Leu Ile  Ser Pro Asn Leu Phe  Arg Val Gln Lys Phe  Ser Leu Lys 
    1370                 1375                 1380             


Asn Tyr  Val Phe Arg His His  Leu Glu Thr Thr Ile  Lys Asp Thr 
    1385                 1390                 1395             


Ser Ser  Ile Leu Arg Gly Ile  Thr Trp Ile Asp Phe  Arg Ser Ser 
    1400                 1405                 1410             


Lys Gly  Leu Asp Thr Ile Val  Lys Val Arg Val Asn  His Ile Gly 
    1415                 1420                 1425             


Gln Ile  Val Ser Val Gly Glu  Tyr 
    1430                 1435     


<210> 80
<211> 1436
<212> PRT
<213> Bacteroides sp.

<400> 80
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Glu Asn Lys Asp Glu Arg Ser Ser Ile Val 
            20                  25                  30          


Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Leu Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Met Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Glu Thr 
65                  70                  75                  80  


Leu Thr Glu Val Leu Lys Glu His Lys Leu Ile Thr Glu Asp Thr Ile 
                85                  90                  95      


Leu Ser Glu Asn Gly Asn Arg Thr Thr Phe Glu Thr Tyr Arg Leu Arg 
            100                 105                 110         


Ala Lys Ala Val Thr Glu Glu Ile Ser Leu Glu Glu Phe Ala Arg Val 
        115                 120                 125             


Leu Leu Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Gly Val Glu Glu Gly Thr Leu Ile Asp Gly Met Asp Ile Ala Arg 
145                 150                 155                 160 


Glu Leu Tyr Asn Asn Asn Leu Thr Pro Gly Glu Leu Cys Leu Gln Leu 
                165                 170                 175     


Leu Asp Ala Gly Lys Lys Phe Leu Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Asn Glu Leu Asp Arg Ile Trp Glu Lys Gln Lys Glu Tyr Tyr Pro 
        195                 200                 205             


Glu Ile Leu Thr Asp Val Leu Lys Glu Glu Leu Arg Gly Lys Lys Arg 
    210                 215                 220                 


Asp Ala Val Trp Ala Ile Cys Ala Lys Tyr Phe Val Trp Lys Glu Asn 
225                 230                 235                 240 


Tyr Thr Glu Trp Asn Lys Glu Lys Gly Lys Thr Glu Gln Gln Glu Arg 
                245                 250                 255     


Glu His Lys Leu Glu Gly Ile Tyr Ser Lys Arg Lys Arg Asp Glu Ala 
            260                 265                 270         


Lys Arg Glu Asn Leu Gln Trp Arg Val Asn Gly Leu Lys Glu Lys Leu 
        275                 280                 285             


Ser Leu Glu Gln Leu Val Ile Val Phe Gln Glu Met Asn Thr Gln Ile 
    290                 295                 300                 


Asn Asn Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Glu 
305                 310                 315                 320 


Leu Tyr Phe Asn Lys Gln Thr Val Gly Gln Tyr Gln Met Glu Met Leu 
                325                 330                 335     


Asp Lys Asn Pro Asn Ala Ser Leu Arg Asn Met Val Phe Tyr Arg Gln 
            340                 345                 350         


Asp Tyr Leu Asp Glu Phe Asn Met Leu Trp Glu Lys Gln Ala Val Tyr 
        355                 360                 365             


His Lys Glu Leu Thr Glu Glu Leu Lys Lys Glu Ile Arg Asp Ile Ile 
    370                 375                 380                 


Ile Phe Tyr Gln Arg Arg Leu Lys Ser Gln Lys Gly Leu Ile Gly Phe 
385                 390                 395                 400 


Cys Glu Phe Glu Ser Arg Gln Ile Glu Val Asp Ile Asp Gly Lys Lys 
                405                 410                 415     


Lys Ile Lys Thr Val Gly Asn Arg Val Ile Ser Arg Ser Ser Pro Leu 
            420                 425                 430         


Phe Gln Glu Phe Lys Ile Trp Gln Ile Leu Asn Asn Ile Glu Val Thr 
        435                 440                 445             


Val Val Gly Lys Lys Arg Lys Arg Arg Lys Leu Lys Glu Asn Tyr Ser 
    450                 455                 460                 


Ala Leu Phe Glu Glu Leu Asn Asp Ala Glu Gln Leu Glu Leu Asn Gly 
465                 470                 475                 480 


Ser Arg Arg Leu Cys Gln Glu Glu Lys Glu Leu Leu Ala Gln Glu Leu 
                485                 490                 495     


Phe Ile Arg Asp Lys Met Thr Lys Ser Glu Val Leu Lys Leu Leu Phe 
            500                 505                 510         


Asp Asn Pro Gln Glu Leu Asp Leu Asn Phe Lys Thr Ile Asp Gly Asn 
        515                 520                 525             


Lys Thr Gly Tyr Ala Leu Phe Gln Ala Tyr Ser Lys Met Ile Glu Met 
    530                 535                 540                 


Ser Gly His Glu Pro Val Asp Phe Lys Lys Pro Val Glu Lys Val Val 
545                 550                 555                 560 


Glu Tyr Ile Lys Ala Val Phe Asp Leu Leu Asn Trp Asn Thr Asp Ile 
                565                 570                 575     


Leu Gly Phe Asn Ser Asn Glu Glu Leu Asp Asn Gln Pro Tyr Tyr Lys 
            580                 585                 590         


Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Pro Thr Gly 
        595                 600                 605             


Asn Gly Arg Leu Ile Gln Lys Met Thr Glu Leu Tyr Gly Phe Glu Lys 
    610                 615                 620                 


Glu Tyr Ala Thr Ile Leu Ala Asn Val Ser Phe Gln Asp Asp Tyr Gly 
625                 630                 635                 640 


Ser Leu Ser Ala Lys Ala Ile His Lys Ile Leu Pro His Leu Lys Glu 
                645                 650                 655     


Gly Asn Arg Tyr Asp Val Ala Cys Val Tyr Ala Gly Tyr Arg His Ser 
            660                 665                 670         


Glu Ser Ser Leu Thr Arg Glu Glu Ile Ala Asn Lys Val Leu Lys Asp 
        675                 680                 685             


Arg Leu Met Leu Leu Pro Lys Asn Ser Leu His Asn Pro Val Val Glu 
    690                 695                 700                 


Lys Ile Leu Asn Gln Met Val Asn Val Ile Asn Val Ile Ile Asp Ile 
705                 710                 715                 720 


Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 
                725                 730                 735     


Lys Asn Ala Lys Glu Arg Glu Glu Leu Thr Lys Ser Ile Ala Gln Thr 
            740                 745                 750         


Thr Lys Ala His Glu Glu Tyr Lys Thr Leu Leu Gln Thr Glu Phe Gly 
        755                 760                 765             


Leu Thr Asn Val Ser Arg Thr Asp Ile Leu Arg Tyr Lys Leu Tyr Lys 
    770                 775                 780                 


Glu Leu Glu Ser Cys Gly Tyr Lys Thr Leu Tyr Ser Asn Thr Tyr Ile 
785                 790                 795                 800 


Ser Arg Glu Lys Leu Phe Ser Lys Glu Phe Asp Ile Glu His Ile Ile 
                805                 810                 815     


Pro Gln Ala Arg Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Glu 
            820                 825                 830         


Ala Arg Ser Val Asn Ile Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe 
        835                 840                 845             


Val Lys Glu Lys Phe Gly Glu Ser Gly Ala Asp Asn Ser Leu Glu His 
    850                 855                 860                 


Tyr Leu Asn Asn Ile Glu Asp Leu Phe Lys Ser Gly Lys Ile Ser Lys 
865                 870                 875                 880 


Thr Lys Tyr Asn Lys Leu Lys Met Ala Glu Gln Asp Ile Pro Asp Gly 
                885                 890                 895     


Phe Ile Glu Arg Asp Leu Arg Asn Thr Gln Tyr Ile Ala Lys Lys Ala 
            900                 905                 910         


Leu Ser Met Leu Asn Glu Ile Ser His Arg Val Val Ala Thr Ser Gly 
        915                 920                 925             


Ser Val Thr Asp Lys Leu Arg Glu Asp Trp Gln Leu Ile Asp Val Met 
    930                 935                 940                 


Lys Glu Leu Asn Trp Glu Lys Tyr Lys Ala Leu Gly Leu Val Glu Tyr 
945                 950                 955                 960 


Phe Glu Asp Arg Asp Gly Arg Gln Ile Gly Arg Ile Lys Asp Trp Thr 
                965                 970                 975     


Lys Arg Asn Asp His Arg His His Ala Met Asp Ala Leu Thr Val Ala 
            980                 985                 990         


Phe Thr Lys Asp Val Phe Ile Gln  Tyr Phe Asn Asn Lys  Asn Ala Ser 
        995                 1000                 1005             


Leu Asp  Pro Asn Ala Asn Glu  His Ala Ile Lys Asn  Lys Tyr Phe 
    1010                 1015                 1020             


Gln Asn  Gly Arg Ala Ile Ala  Pro Met Pro Leu Arg  Glu Phe Arg 
    1025                 1030                 1035             


Ala Glu  Ala Lys Lys His Leu  Glu Asn Thr Leu Ile  Ser Ile Lys 
    1040                 1045                 1050             


Ala Lys  Asn Lys Val Ile Thr  Gly Asn Ile Asn Lys  Thr Arg Lys 
    1055                 1060                 1065             


Lys Gly  Gly Val Asn Lys Asn  Met Gln Gln Thr Pro  Arg Gly Gln 
    1070                 1075                 1080             


Leu His  Leu Glu Thr Ile Tyr  Gly Ser Gly Lys Gln  Tyr Leu Thr 
    1085                 1090                 1095             


Lys Glu  Glu Lys Val Asn Ala  Ser Phe Asp Met Arg  Lys Ile Gly 
    1100                 1105                 1110             


Thr Val  Ser Lys Ser Ala Tyr  Arg Asp Ala Leu Leu  Lys Arg Leu 
    1115                 1120                 1125             


Tyr Glu  Asn Asp Asn Asp Pro  Lys Lys Ala Phe Ala  Gly Lys Asn 
    1130                 1135                 1140             


Ser Leu  Asp Lys Gln Pro Ile  Trp Leu Asp Lys Glu  Gln Met Arg 
    1145                 1150                 1155             


Lys Val  Pro Glu Lys Val Lys  Ile Val Thr Leu Glu  Ala Ile Tyr 
    1160                 1165                 1170             


Thr Ile  Arg Lys Glu Ile Ser  Pro Asp Leu Lys Val  Asp Lys Val 
    1175                 1180                 1185             


Ile Asp  Val Gly Val Arg Lys  Ile Leu Ile Asp Arg  Leu Asn Glu 
    1190                 1195                 1200             


Tyr Gly  Asn Asp Ala Lys Lys  Ala Phe Ser Asn Leu  Asp Lys Asn 
    1205                 1210                 1215             


Pro Ile  Trp Leu Asn Lys Glu  Lys Gly Ile Ser Ile  Lys Arg Val 
    1220                 1225                 1230             


Thr Ile  Ser Gly Ile Ser Asn  Ala Gln Ser Leu His  Val Lys Lys 
    1235                 1240                 1245             


Asp Lys  Asp Gly Lys Pro Ile  Leu Asp Glu Asn Gly  Arg Asn Ile 
    1250                 1255                 1260             


Pro Val  Asp Phe Val Asn Thr  Gly Asn Asn His His  Val Ala Val 
    1265                 1270                 1275             


Tyr Tyr  Arg Pro Val Ile Asp  Lys Arg Gly Gln Leu  Val Val Asp 
    1280                 1285                 1290             


Glu Ala  Gly Asn Pro Lys Tyr  Glu Leu Glu Glu Val  Val Val Ser 
    1295                 1300                 1305             


Phe Phe  Glu Ala Val Thr Arg  Ala Asn Leu Gly Leu  Pro Ile Ile 
    1310                 1315                 1320             


Asp Lys  Asp Tyr Lys Thr Thr  Glu Gly Trp Gln Phe  Leu Phe Ser 
    1325                 1330                 1335             


Met Lys  Gln Asn Glu Tyr Phe  Val Phe Pro Asn Glu  Lys Thr Gly 
    1340                 1345                 1350             


Phe Asn  Pro Lys Glu Ile Asp  Leu Leu Asp Val Glu  Asn Tyr Gly 
    1355                 1360                 1365             


Leu Ile  Ser Pro Asn Leu Phe  Arg Val Gln Lys Phe  Ser Leu Lys 
    1370                 1375                 1380             


Asn Tyr  Val Phe Arg His His  Leu Glu Thr Thr Ile  Lys Asp Thr 
    1385                 1390                 1395             


Ser Ser  Ile Leu Arg Gly Ile  Thr Trp Ile Asp Phe  Arg Ser Ser 
    1400                 1405                 1410             


Lys Gly  Leu Asp Thr Ile Val  Lys Val Arg Val Asn  His Ile Gly 
    1415                 1420                 1425             


Gln Ile  Val Ser Val Gly Glu  Tyr 
    1430                 1435     


<210> 81
<211> 1512
<212> PRT
<213> Bacteroides nordii


<220>
<223> Bacteroides nordii CL02T12C05

<400> 81
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Ser Glu Glu Asp Gly Pro Ile Val Lys Lys Arg Ile 
            20                  25                  30          


Glu Leu Ala Gly Ser Arg Ile Ile Pro Met Asp Ala Ala Val Leu Gly 
        35                  40                  45              


Asn Phe Asp Ser Gly Val Thr Lys Ser Gln Thr Ala Glu Arg Thr Ser 
    50                  55                  60                  


Phe Arg Ser Ile Arg Arg Leu Arg Glu Arg Gln Leu Leu Arg Arg Glu 
65                  70                  75                  80  


Arg Leu His Lys Val Leu Gln Ile Leu Gly Phe Leu Pro Glu His Tyr 
                85                  90                  95      


Val Asn Asp Ile Asp Phe Glu Asn His Pro Gly Lys Ile Lys Arg Asn 
            100                 105                 110         


Thr Glu Pro Lys Leu Pro Trp Arg Lys Asn Ser Met Gly Gln Phe Glu 
        115                 120                 125             


Phe Ile Phe Gln Asp Ser Phe Glu Ala Met Leu Thr Asp Phe Ala Thr 
    130                 135                 140                 


His Gln Pro Val Phe Val Ser Glu Gly Lys Lys Val Pro Tyr Asp Trp 
145                 150                 155                 160 


Thr Leu Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Glu Gly Ile Ser Lys 
                165                 170                 175     


Glu Glu Leu Ala Trp Leu Ile Leu Asn Phe Asn Gln Lys Arg Gly Tyr 
            180                 185                 190         


Tyr Gln Leu Arg Gly Glu Glu Glu Glu Glu Gln Ser Asn Lys Leu Val 
        195                 200                 205             


Glu Phe Tyr Ala Leu Arg Val Val Lys Val Glu Ala Thr Asp Asp Lys 
    210                 215                 220                 


Lys Gly Lys Asp Thr Trp Tyr Asn Val His Leu Glu Asn Gly Trp Ile 
225                 230                 235                 240 


Tyr Arg Arg Thr Ser Asn Ile Pro Leu Asp Trp Glu Gly Lys Val Lys 
                245                 250                 255     


Glu Phe Ile Val Thr Thr Asp Leu Asn Glu Asp Gly Thr Pro Lys Leu 
            260                 265                 270         


Asp Lys Tyr Gly Glu Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp 
        275                 280                 285             


Asp Trp Thr Leu Ile Lys Lys Lys Thr Glu Ser Asp Ile Ala Asn Ser 
    290                 295                 300                 


His Lys Thr Val Gly Cys Tyr Ile Tyr Asp Ala Leu Leu Gln Asn Pro 
305                 310                 315                 320 


His Gln Lys Ile Lys Gly Arg Leu Val Arg Thr Val Glu Arg Lys Phe 
                325                 330                 335     


Tyr Lys Glu Glu Leu Arg Leu Ile Leu Glu Lys Gln Leu Ser Phe His 
            340                 345                 350         


Pro Glu Leu Gln Asp Arg Asp Leu Tyr Arg Ala Cys Ile Asp Ala Leu 
        355                 360                 365             


Tyr Val Ser Asn Glu Ala His Lys Asn Asn Ile Ser Gly Arg Asp Phe 
    370                 375                 380                 


Val Tyr Leu Phe Ile Asp Asp Ile Ile Phe Tyr Gln Arg Pro Leu Lys 
385                 390                 395                 400 


Thr Lys Lys Ser Leu Ile Asp Asn Cys Pro Tyr Glu Glu Asn Gln Tyr 
                405                 410                 415     


Met Asp Arg Glu Thr Gly Glu Val Lys Gln Ala Pro Ile Lys Cys Ile 
            420                 425                 430         


Ala Lys Ser His Pro Leu Phe Gln Glu Phe Arg Leu Trp Gln Phe Ile 
        435                 440                 445             


Ser Asn Ile Arg Ile Tyr Gln Arg Glu Arg Val Leu Asp Asp Gly Lys 
    450                 455                 460                 


Leu Glu Thr Asp Val Asp Val Thr Pro Asp Phe Leu Lys Thr Glu Asp 
465                 470                 475                 480 


Asp Tyr Thr Thr Leu Phe Glu Trp Phe Asn Asp Arg Lys Glu Val Asp 
                485                 490                 495     


Gln Lys Ala Phe Leu Lys Asn Pro Gln Phe Gly Leu Lys Lys Thr Phe 
            500                 505                 510         


Thr Glu Tyr Arg Trp Asn Tyr Val Glu Asp Lys Ser Tyr Pro Cys Asn 
        515                 520                 525             


Glu Thr Arg Asn Ala Ile Leu Asn Gly Leu Gln Lys Ala Gly Val Ser 
    530                 535                 540                 


Ala Asp Phe Leu Ser Arg Glu Val Glu Glu Ala Leu Trp His Ile Leu 
545                 550                 555                 560 


Tyr Ser Val Glu Asp Lys Ile Glu Ile Glu Ser Ala Leu Arg Lys Phe 
                565                 570                 575     


Ala Ser Lys His Asp Leu Asp Asp Arg Phe Ala Asp Val Phe Lys Lys 
            580                 585                 590         


Leu Pro Pro Phe Lys Lys Glu Tyr Gly Ala Tyr Ser Ala Lys Ala Ile 
        595                 600                 605             


Lys Lys Leu Leu Pro Leu Met Arg Ile Gly Lys Tyr Trp Glu Leu Ser 
    610                 615                 620                 


Asn Ile Asp Asp Lys Thr Lys Glu Arg Ile Asp Lys Ile Ile Thr Gly 
625                 630                 635                 640 


Glu Trp Asp Glu Asn Ile His Asp Arg Val Arg Glu Lys Ala Ile Lys 
                645                 650                 655     


Leu Ser Asp Ile Thr Asp Phe Lys Gly Leu Pro Leu Trp Leu Ser Cys 
            660                 665                 670         


Tyr Val Val Tyr Asn Arg His Ser Glu Ala Arg Ala Ile Ala Lys Trp 
        675                 680                 685             


Glu Ser Pro Glu Asp Ile Asp Ser Tyr Leu Arg Leu Phe Arg Gln His 
    690                 695                 700                 


Ser Leu Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu Arg 
705                 710                 715                 720 


Thr Val Arg Asp Ile Trp Lys Arg Val Gly Gln Ile Asp Glu Ile His 
                725                 730                 735     


Val Glu Leu Gly Arg Glu Ile Lys Asn Pro Ala Asp Lys Arg Ala Lys 
            740                 745                 750         


Met Thr Ala Gln Ile Val Glu Asn Glu Asn Thr Asn Leu Arg Ile Lys 
        755                 760                 765             


Ala Leu Leu Ala Glu Phe Ile Asn Ser Glu Tyr Glu Ile Glu Asn Val 
    770                 775                 780                 


Arg Pro Tyr Ser Ser Asn Gln Gln Glu Lys Leu Lys Ile Tyr Glu Asp 
785                 790                 795                 800 


Thr Val Leu Asn Gly Val Lys Glu Ile Pro Glu Asp Ile Asn Thr Ile 
                805                 810                 815     


Leu Lys Lys Phe Arg Glu Ser Asp Leu Lys Lys Arg Pro Thr Lys Ser 
            820                 825                 830         


Asp Phe Leu His Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Cys Ser Pro 
        835                 840                 845             


Tyr Thr Gly Arg Ile Ile Pro Leu Gly Lys Leu Phe Thr Ser Ala Tyr 
    850                 855                 860                 


Glu Ile Glu His Ile Ile Pro Gln Ala His Tyr Phe Asp Asp Ser Phe 
865                 870                 875                 880 


Ser Asn Lys Val Ile Cys Glu Ala Glu Val Asn Gly Leu Lys Asp Lys 
                885                 890                 895     


Lys Leu Gly Tyr Glu Phe Ile Lys His Asn Pro Gly Lys Met Val Glu 
            900                 905                 910         


Ile Gly Phe Gly Lys Pro Pro Val Arg Ile Phe Ser Val Glu Glu Tyr 
        915                 920                 925             


Glu Arg Phe Val Lys Glu Asn Tyr Ser Gly Ile Lys Asn Lys Met Asn 
    930                 935                 940                 


Lys Leu Leu Met Asp Asp Ile Pro Glu Thr Phe Ile Glu Arg Gln Leu 
945                 950                 955                 960 


Asn Asp Ser Arg Tyr Ile Ser Lys Val Val Lys Ser Leu Leu Ser Asn 
                965                 970                 975     


Ile Val Arg Glu Lys Asp Ser Asn Gly Glu Tyr Glu Pro Glu Ala Ile 
            980                 985                 990         


Ser Lys Asn Val Ile Val Cys Thr  Gly Ser Val Thr Asp  Arg Leu Lys 
        995                 1000                 1005             


Arg Asp  Trp Gly Val Asn Asp  Val Trp Asn Ser Ile  Ile Tyr Pro 
    1010                 1015                 1020             


Arg Phe  Glu Arg Leu Asn Glu  Leu Thr Gly Ser Gln  Gln Phe Gly 
    1025                 1030                 1035             


Cys Trp  Glu Asn Lys Glu Gly  Lys Arg Val Phe Gln  Thr Ala Val 
    1040                 1045                 1050             


Pro Leu  Glu Met Gln Lys Gly  Phe Ser Lys Lys Arg  Ile Asp His 
    1055                 1060                 1065             


Arg His  His Ala Met Asp Ala  Ile Val Ile Ala Cys  Ala Thr Arg 
    1070                 1075                 1080             


Asn His  Ile Asn Tyr Leu Ser  Asn Glu Ser Ala Ser  Lys Lys Ala 
    1085                 1090                 1095             


Lys Ile  Ser Arg Thr Asp Leu  Gln Arg Leu Leu Cys  Thr Lys Cys 
    1100                 1105                 1110             


Arg Thr  Asp Asp Asn Gly Asn  Tyr Lys Trp Ile Val  Lys Lys Pro 
    1115                 1120                 1125             


Trp Pro  Ala Phe Thr Gln Asp  Ile Arg Lys Ala Leu  Glu Asn Ile 
    1130                 1135                 1140             


Thr Val  Ser Phe Lys Gln Asn  Leu Arg Val Ile Asn  Lys Thr Thr 
    1145                 1150                 1155             


Asn Tyr  Tyr Val His Phe Asp  Glu Ser Gly Lys Lys  Val Leu Glu 
    1160                 1165                 1170             


Lys Gln  Ile Asn Gly Asp Ser  Trp Ala Ile Arg Lys  Pro Met His 
    1175                 1180                 1185             


Lys Asp  Thr Val Phe Gly Lys  Val Asn Leu Gln Lys  Val Lys Glu 
    1190                 1195                 1200             


Val Arg  Leu Ser Leu Ala Leu  Asp Thr Pro Lys Met  Ile Val Asp 
    1205                 1210                 1215             


Lys Lys  Leu Lys Glu Lys Val  Leu Gln Leu Tyr Ser  Tyr Lys Tyr 
    1220                 1225                 1230             


Asp Lys  Lys Arg Ile Asp Lys  Tyr Phe Lys Glu Asn  Ala Ser Leu 
    1235                 1240                 1245             


Trp Lys  Asp Leu Asn Leu Ser  Lys Val Ala Val Tyr  Tyr Phe Thr 
    1250                 1255                 1260             


Asn Asp  Ser Thr Glu Pro Leu  Val Ala Val Arg Lys  Pro Leu Asp 
    1265                 1270                 1275             


Thr Ser  Phe Asn Ala Lys Lys  Ile Lys Glu Ser Val  Thr Asp Thr 
    1280                 1285                 1290             


Gly Ile  Gln Lys Ile Leu Leu  Asn His Leu Ser Asn  Asn Gln Asp 
    1295                 1300                 1305             


Asp Pro  Asn Leu Ala Phe Ser  Pro Asp Gly Ile Asp  Lys Met Asn 
    1310                 1315                 1320             


Lys Asn  Leu Thr Ala Leu Asn  Asp Gly Lys Tyr His  Gln Pro Ile 
    1325                 1330                 1335             


Tyr Lys  Val Arg Val Cys Glu  Pro Gln Gly Asn Lys  Phe Ser Val 
    1340                 1345                 1350             


Gly Thr  Ser Gly Asn Lys Thr  Ser Lys Tyr Val Glu  Ala Ala Lys 
    1355                 1360                 1365             


Gly Thr  Asn Leu Phe Phe Ala  Val Tyr Gln Thr Glu  Asp Gly Lys 
    1370                 1375                 1380             


Arg Ser  Tyr Glu Thr Ile Pro  Leu Asn Val Val Ile  Glu Arg Glu 
    1385                 1390                 1395             


Lys Leu  Gly Trp Thr Pro Val  Pro Glu Asn Asn Asn  Asn Gly Asp 
    1400                 1405                 1410             


Lys Leu  Leu Phe Trp Leu Ser  Pro Asn Asp Leu Val  Tyr Val Pro 
    1415                 1420                 1425             


Thr Ala  Asp Glu Leu Asn Asn  Gly Met Arg Leu Asp  Asn Met Asp 
    1430                 1435                 1440             


Lys Gly  Arg Ile Tyr Lys Met  Ile Ser Cys Ser Gly  Pro Gln Cys 
    1445                 1450                 1455             


Phe Phe  Ile Pro Gln Asn Val  Ser Asn Ala Ile Ile  Pro Val Ile 
    1460                 1465                 1470             


Glu Leu  Gly Ala Asn Asn Lys  Ala Glu Lys Ser Trp  Asn Asn Glu 
    1475                 1480                 1485             


Met Ile  Lys Val Val Cys Val  Pro Ile Arg Val Asp  Arg Leu Gly 
    1490                 1495                 1500             


Cys Ile  Thr Gln Ile Asn Asn  Gln Lys 
    1505                 1510         


<210> 82
<211> 1436
<212> PRT
<213> Bacteroides sp.


<220>
<223> Bacteroides sp. 2_1_16

<400> 82
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Glu Asn Lys Asp Glu Arg Ser Ser Ile Val 
            20                  25                  30          


Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Leu Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Met Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Glu Thr 
65                  70                  75                  80  


Leu Thr Glu Val Leu Lys Glu His Lys Leu Ile Thr Glu Asp Thr Ile 
                85                  90                  95      


Leu Ser Glu Asn Gly Asn Arg Thr Thr Phe Glu Thr Tyr Arg Leu Arg 
            100                 105                 110         


Ala Lys Ala Val Thr Glu Glu Ile Ser Leu Glu Glu Phe Ala Arg Val 
        115                 120                 125             


Leu Leu Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Gly Val Glu Glu Gly Thr Leu Ile Asp Gly Met Asp Ile Ala Arg 
145                 150                 155                 160 


Glu Leu Tyr Asn Asn Asn Leu Thr Pro Gly Glu Leu Cys Leu Gln Leu 
                165                 170                 175     


Leu Asp Ala Gly Lys Lys Phe Leu Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Asn Glu Leu Asp Arg Ile Trp Glu Lys Gln Lys Glu Tyr Tyr Pro 
        195                 200                 205             


Glu Ile Leu Thr Asp Val Leu Lys Glu Glu Leu Arg Gly Lys Lys Arg 
    210                 215                 220                 


Asp Ala Val Trp Ala Ile Cys Ala Lys Tyr Phe Val Trp Lys Glu Thr 
225                 230                 235                 240 


Tyr Thr Glu Trp Asn Lys Glu Lys Gly Lys Thr Glu Gln Gln Glu Arg 
                245                 250                 255     


Glu His Lys Leu Glu Gly Ile Tyr Ser Lys Arg Lys Arg Asp Glu Ala 
            260                 265                 270         


Lys Arg Glu Asn Leu Gln Trp Arg Val Asn Gly Leu Lys Glu Lys Leu 
        275                 280                 285             


Ser Leu Glu Gln Leu Val Ile Val Phe Gln Glu Met Asn Thr Gln Ile 
    290                 295                 300                 


Asn Asn Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Glu 
305                 310                 315                 320 


Leu Tyr Phe Asn Lys Gln Thr Val Gly Gln Tyr Gln Met Glu Met Leu 
                325                 330                 335     


Asp Lys Asn Pro Asn Ala Ser Leu Arg Asn Met Val Phe Tyr Arg Gln 
            340                 345                 350         


Asp Tyr Leu Asp Glu Phe Asn Met Leu Trp Glu Lys Gln Ala Val Tyr 
        355                 360                 365             


His Lys Glu Leu Thr Glu Glu Leu Lys Lys Glu Ile Arg Asp Ile Ile 
    370                 375                 380                 


Ile Phe Tyr Gln Arg Arg Leu Lys Ser Gln Lys Gly Leu Ile Gly Phe 
385                 390                 395                 400 


Cys Glu Phe Glu Ser Arg Gln Ile Glu Val Asp Ile Asp Gly Lys Lys 
                405                 410                 415     


Lys Ile Lys Thr Val Gly Asn Arg Val Ile Ser Arg Ser Ser Pro Leu 
            420                 425                 430         


Phe Gln Glu Phe Lys Ile Trp Gln Ile Leu Asn Asn Ile Glu Val Thr 
        435                 440                 445             


Val Val Gly Lys Lys Arg Lys Arg Arg Lys Leu Lys Glu Asn Tyr Ser 
    450                 455                 460                 


Ala Ile Phe Glu Glu Leu Asn Asp Ala Glu Gln Leu Glu Leu Asn Gly 
465                 470                 475                 480 


Ser Arg Arg Leu Cys Gln Glu Glu Lys Glu Leu Leu Ala Gln Glu Leu 
                485                 490                 495     


Phe Val Arg Asp Lys Met Thr Lys Ser Glu Val Leu Lys Leu Leu Phe 
            500                 505                 510         


Asp Asn Pro Gln Glu Leu Asp Leu Asn Phe Lys Thr Ile Asp Gly Asn 
        515                 520                 525             


Lys Thr Gly Tyr Ala Leu Phe Gln Ala Tyr Ser Lys Met Ile Glu Met 
    530                 535                 540                 


Ser Gly His Glu Pro Val Asp Phe Lys Lys Pro Val Glu Lys Val Val 
545                 550                 555                 560 


Glu Tyr Ile Lys Ala Val Phe Asp Leu Leu Asn Trp Asn Thr Asp Ile 
                565                 570                 575     


Leu Gly Phe Asn Ser Asn Glu Glu Leu Asp Asn Gln Ser Tyr Tyr Lys 
            580                 585                 590         


Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Pro Thr Gly 
        595                 600                 605             


Asn Gly Arg Leu Ile Gln Lys Met Thr Glu Leu Tyr Gly Phe Glu Lys 
    610                 615                 620                 


Glu Tyr Ala Thr Ile Leu Ala Asn Val Ser Phe Gln Asp Asp Tyr Gly 
625                 630                 635                 640 


Ser Leu Ser Ala Lys Ala Ile His Lys Ile Leu Pro His Leu Lys Glu 
                645                 650                 655     


Gly Asn Arg Tyr Asp Val Ala Cys Val Tyr Ala Gly Tyr Arg His Ser 
            660                 665                 670         


Glu Ser Ser Leu Thr Arg Glu Glu Ile Ala Asn Lys Val Leu Lys Asp 
        675                 680                 685             


Arg Leu Met Leu Leu Pro Lys Asn Ser Leu His Asn Pro Val Val Glu 
    690                 695                 700                 


Lys Ile Leu Asn Gln Met Val Asn Val Ile Asn Val Ile Ile Asp Ile 
705                 710                 715                 720 


Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 
                725                 730                 735     


Lys Asn Ala Lys Glu Arg Glu Glu Leu Thr Lys Ser Ile Ala Gln Thr 
            740                 745                 750         


Thr Lys Ala Asn Glu Glu Tyr Lys Thr Leu Leu Gln Thr Glu Phe Gly 
        755                 760                 765             


Leu Thr Asn Val Ser Arg Thr Asp Ile Leu Arg Tyr Lys Leu Tyr Lys 
    770                 775                 780                 


Glu Leu Glu Ser Cys Gly Tyr Lys Thr Leu Tyr Ser Asn Thr Tyr Ile 
785                 790                 795                 800 


Ser Arg Glu Lys Leu Phe Ser Lys Glu Phe Asp Ile Glu His Ile Ile 
                805                 810                 815     


Pro Gln Ala Arg Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Glu 
            820                 825                 830         


Ala Arg Ser Val Asn Ile Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe 
        835                 840                 845             


Val Lys Glu Lys Phe Gly Glu Ser Gly Ala Asp Asn Ser Leu Glu His 
    850                 855                 860                 


Tyr Leu Asn Asn Ile Glu Asp Leu Phe Lys Ser Gly Lys Ile Ser Lys 
865                 870                 875                 880 


Thr Lys Tyr Asn Lys Leu Lys Met Ala Glu Gln Asp Ile Pro Asp Gly 
                885                 890                 895     


Phe Ile Glu Arg Asp Leu Arg Asn Thr Gln Tyr Ile Ala Lys Lys Ala 
            900                 905                 910         


Leu Ser Met Leu Asn Glu Ile Ser His Arg Val Val Ala Thr Ser Gly 
        915                 920                 925             


Ser Val Thr Asp Lys Leu Arg Glu Asp Trp Gln Leu Ile Asp Val Met 
    930                 935                 940                 


Lys Glu Leu Asn Trp Glu Lys Tyr Lys Ala Leu Gly Leu Val Glu Tyr 
945                 950                 955                 960 


Phe Glu Asp Arg Asp Gly Arg Gln Ile Gly Arg Ile Lys Asp Trp Thr 
                965                 970                 975     


Lys Arg Asn Asp His Arg His His Ala Met Asp Ala Leu Thr Val Ala 
            980                 985                 990         


Phe Thr Lys Asp Val Phe Ile Gln  Tyr Phe Asn Asn Lys  Asn Ala Ser 
        995                 1000                 1005             


Leu Asp  Pro Asn Ala Asn Glu  His Ala Ile Lys Asn  Lys Tyr Phe 
    1010                 1015                 1020             


Gln Asn  Gly Arg Ala Ile Ala  Pro Met Pro Leu Arg  Glu Phe Arg 
    1025                 1030                 1035             


Ala Glu  Ala Lys Lys His Leu  Glu Asn Thr Leu Ile  Ser Ile Lys 
    1040                 1045                 1050             


Ala Lys  Asn Lys Val Ile Thr  Gly Asn Ile Asn Lys  Thr Arg Lys 
    1055                 1060                 1065             


Lys Gly  Gly Val Asn Lys Asn  Met Gln Gln Thr Pro  Arg Gly Gln 
    1070                 1075                 1080             


Leu His  Leu Glu Thr Ile Tyr  Gly Ser Gly Lys Gln  Tyr Leu Thr 
    1085                 1090                 1095             


Lys Glu  Glu Lys Val Asn Ala  Ser Phe Asp Met Arg  Lys Ile Glu 
    1100                 1105                 1110             


Thr Val  Ser Lys Ser Ala Tyr  Arg Asp Ala Leu Leu  Lys Arg Leu 
    1115                 1120                 1125             


Tyr Glu  Asn Asp Asn Asp Pro  Lys Lys Ala Phe Ala  Gly Lys Asn 
    1130                 1135                 1140             


Ser Leu  Asp Lys Gln Pro Ile  Trp Leu Asp Lys Glu  Gln Met Arg 
    1145                 1150                 1155             


Lys Val  Pro Glu Lys Val Lys  Ile Val Thr Leu Glu  Ala Ile Tyr 
    1160                 1165                 1170             


Thr Ile  Arg Lys Glu Ile Ser  Pro Asp Leu Lys Val  Asp Lys Val 
    1175                 1180                 1185             


Ile Asp  Val Gly Val Arg Lys  Ile Leu Ile Asp Arg  Leu Asn Glu 
    1190                 1195                 1200             


Tyr Gly  Asn Asp Ala Lys Lys  Ala Phe Ser Asn Leu  Asp Lys Asn 
    1205                 1210                 1215             


Pro Ile  Trp Leu Asn Lys Glu  Lys Gly Ile Ser Ile  Lys Arg Val 
    1220                 1225                 1230             


Thr Ile  Ser Gly Ile Ser Asn  Ala Gln Ser Leu His  Val Lys Lys 
    1235                 1240                 1245             


Asp Lys  Asp Gly Lys Pro Ile  Leu Asp Glu Asn Gly  Arg Asn Ile 
    1250                 1255                 1260             


Pro Val  Asp Phe Val Asn Thr  Gly Asn Asn His His  Val Ala Val 
    1265                 1270                 1275             


Tyr Tyr  Arg Pro Val Ile Asp  Lys Arg Gly Gln Leu  Val Val Asp 
    1280                 1285                 1290             


Glu Ala  Gly Asn Pro Lys Tyr  Glu Leu Glu Glu Val  Val Val Ser 
    1295                 1300                 1305             


Phe Phe  Glu Ala Val Thr Arg  Ala Asn Leu Gly Leu  Pro Ile Ile 
    1310                 1315                 1320             


Asp Lys  Asp Tyr Lys Thr Thr  Glu Gly Trp Gln Phe  Leu Phe Ser 
    1325                 1330                 1335             


Met Lys  Gln Asn Glu Tyr Phe  Val Phe Pro Asn Glu  Lys Ile Gly 
    1340                 1345                 1350             


Phe Asn  Pro Lys Glu Ile Asp  Leu Leu Asp Val Glu  Asn Tyr Gly 
    1355                 1360                 1365             


Leu Ile  Ser Pro Asn Leu Phe  Arg Val Gln Lys Phe  Ser Leu Lys 
    1370                 1375                 1380             


Asn Tyr  Val Phe Arg His His  Leu Glu Thr Thr Ile  Lys Asp Thr 
    1385                 1390                 1395             


Ser Ser  Ile Leu Arg Gly Ile  Thr Trp Ile Asp Phe  Arg Ser Ser 
    1400                 1405                 1410             


Lys Gly  Leu Asp Thr Ile Val  Lys Val Arg Val Asn  His Ile Gly 
    1415                 1420                 1425             


Gln Ile  Val Ser Val Gly Glu  Tyr 
    1430                 1435     


<210> 83
<211> 1517
<212> PRT
<213> Bacteroides sp.


<220>
<223> Bacteroides sp. 20_3

<400> 83
Met Lys Lys Ile Val Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Ile Asn Ala Tyr Ile Asn Lys Glu His Leu Tyr Gly Ile Glu 
            20                  25                  30          


Ala Cys Gly Ser Arg Ile Ile Pro Met Asp Ala Ala Ile Leu Gly Asn 
        35                  40                  45              


Phe Asp Lys Gly Asn Ser Ile Ser Gln Thr Ala Asp Arg Thr Ser Tyr 
    50                  55                  60                  


Arg Gly Ile Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg 
65                  70                  75                  80  


Leu His Arg Ile Leu Asp Leu Leu Gly Phe Leu Pro Lys His Tyr Ser 
                85                  90                  95      


Asp Ser Leu Asn Arg Tyr Gly Lys Phe Leu Asn Asp Ile Glu Cys Lys 
            100                 105                 110         


Leu Pro Trp Val Lys Asp Glu Thr Gly Ser Tyr Lys Phe Ile Phe Gln 
        115                 120                 125             


Glu Ser Phe Lys Glu Met Leu Ala Asn Phe Thr Glu His His Pro Ile 
    130                 135                 140                 


Leu Ile Ala Asn Asn Lys Lys Val Pro Tyr Asp Trp Thr Ile Tyr Tyr 
145                 150                 155                 160 


Leu Arg Lys Lys Ala Leu Thr Gln Lys Ile Ser Lys Glu Glu Leu Ala 
                165                 170                 175     


Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg 
            180                 185                 190         


Gly Glu Glu Glu Glu Thr Pro Asn Lys Leu Val Glu Tyr Tyr Ser Leu 
        195                 200                 205             


Lys Val Glu Lys Val Glu Asp Ser Gly Glu Arg Lys Gly Lys Asp Thr 
    210                 215                 220                 


Trp Tyr Asn Val His Leu Glu Asn Gly Met Ile Tyr Arg Arg Thr Ser 
225                 230                 235                 240 


Asn Ile Pro Leu Asp Trp Glu Gly Lys Thr Lys Glu Phe Ile Val Thr 
                245                 250                 255     


Thr Asp Leu Glu Ala Asp Gly Ser Pro Lys Lys Asp Lys Glu Gly Asn 
            260                 265                 270         


Ile Lys Arg Ser Phe Arg Ala Pro Lys Asp Asp Asp Trp Thr Leu Ile 
        275                 280                 285             


Lys Lys Lys Thr Glu Ala Asp Ile Asp Lys Ile Lys Met Thr Val Gly 
    290                 295                 300                 


Ala Tyr Ile Tyr Asp Thr Leu Leu Gln Lys Pro Asp Gln Lys Ile Arg 
305                 310                 315                 320 


Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Tyr Tyr Lys Asn Glu Leu 
                325                 330                 335     


Tyr Gln Ile Leu Lys Thr Gln Ser Glu Phe His Glu Glu Leu Arg Asp 
            340                 345                 350         


Lys Gln Leu Tyr Ile Ala Cys Leu Asn Glu Leu Tyr Pro Asn Asn Glu 
        355                 360                 365             


Pro Arg Arg Asn Ser Ile Ser Thr Arg Asp Phe Cys His Leu Phe Ile 
    370                 375                 380                 


Glu Asp Ile Ile Phe Tyr Gln Arg Pro Leu Lys Ser Lys Lys Ser Leu 
385                 390                 395                 400 


Ile Asp Asn Cys Pro Tyr Glu Glu Asn Arg Tyr Ile Asp Lys Glu Ser 
                405                 410                 415     


Gly Glu Ile Lys His Ala Ser Ile Lys Cys Ile Ala Lys Ser His Pro 
            420                 425                 430         


Leu Tyr Gln Glu Phe Arg Leu Trp Gln Phe Ile Val Asn Leu Arg Ile 
        435                 440                 445             


Tyr Arg Lys Glu Thr Asp Val Asp Val Thr Gln Glu Leu Leu Pro Thr 
    450                 455                 460                 


Glu Ala Asp Tyr Val Thr Leu Phe Glu Trp Leu Asn Glu Lys Lys Glu 
465                 470                 475                 480 


Ile Asp Gln Lys Ala Phe Phe Lys Tyr Pro Pro Phe Gly Phe Lys Lys 
                485                 490                 495     


Thr Thr Ser Asn Tyr Arg Trp Asn Tyr Val Glu Asp Lys Pro Tyr Pro 
            500                 505                 510         


Cys Asn Glu Thr His Ala Gln Ile Ile Ala Arg Leu Gly Lys Ala His 
        515                 520                 525             


Ile Pro Lys Ala Phe Leu Ser Lys Glu Lys Glu Glu Thr Leu Trp His 
    530                 535                 540                 


Ile Leu Tyr Ser Ile Glu Asp Lys Gln Glu Ile Glu Lys Ala Leu His 
545                 550                 555                 560 


Ser Phe Ala Asn Lys Asn Asn Leu Ser Glu Glu Phe Ile Glu Gln Phe 
                565                 570                 575     


Lys Asn Phe Pro Pro Phe Lys Lys Glu Tyr Gly Ser Tyr Ser Ala Lys 
            580                 585                 590         


Ala Ile Lys Lys Leu Leu Pro Leu Met Arg Met Gly Lys Tyr Trp Ser 
        595                 600                 605             


Ile Glu Asn Ile Asp Asn Gly Thr Arg Ile Arg Ile Asn Lys Ile Ile 
    610                 615                 620                 


Asp Gly Glu Tyr Asp Glu Asn Ile Arg Glu Arg Val Arg Gln Lys Ala 
625                 630                 635                 640 


Ile Asn Leu Thr Asp Ile Thr His Phe Arg Ala Leu Pro Leu Trp Leu 
                645                 650                 655     


Ala Cys Tyr Leu Val Tyr Asp Arg His Ser Glu Val Lys Asp Ile Val 
            660                 665                 670         


Lys Trp Lys Thr Pro Lys Asp Ile Asp Leu Tyr Leu Lys Ser Phe Lys 
        675                 680                 685             


Gln His Ser Leu Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr 
    690                 695                 700                 


Leu Arg Thr Val Arg Asp Ile Trp Gln Gln Val Gly His Ile Asp Glu 
705                 710                 715                 720 


Ile His Ile Glu Leu Gly Arg Glu Met Lys Asn Pro Ala Asp Lys Arg 
                725                 730                 735     


Ala Arg Met Ser Gln Gln Met Ile Lys Asn Glu Asn Thr Asn Leu Arg 
            740                 745                 750         


Ile Lys Ala Leu Leu Thr Glu Phe Leu Asn Pro Glu Phe Gly Ile Glu 
        755                 760                 765             


Asn Val Arg Pro Tyr Ser Pro Ser Gln Gln Asp Leu Leu Arg Ile Tyr 
    770                 775                 780                 


Glu Glu Gly Val Leu Asn Ser Ile Leu Glu Leu Pro Glu Asp Ile Gly 
785                 790                 795                 800 


Ile Ile Leu Gly Lys Phe Asn Gln Thr Asp Thr Leu Lys Arg Pro Thr 
                805                 810                 815     


Arg Ser Glu Ile Leu Arg Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Arg 
            820                 825                 830         


Ser Pro Tyr Thr Gly Glu Met Ile Pro Leu Ser Lys Leu Phe Thr Pro 
        835                 840                 845             


Ala Tyr Glu Ile Glu His Ile Ile Pro Gln Ser Arg Tyr Phe Asp Asp 
    850                 855                 860                 


Ser Leu Ser Asn Lys Val Ile Cys Glu Ser Glu Ile Asn Lys Leu Lys 
865                 870                 875                 880 


Asp Arg Ser Leu Gly Tyr Glu Phe Ile Lys Asn His His Gly Glu Lys 
                885                 890                 895     


Val Glu Leu Ala Phe Asp Lys Pro Val Glu Val Leu Ser Val Glu Ala 
            900                 905                 910         


Tyr Glu Lys Leu Val His Glu Ser Tyr Ser His Asn Arg Ser Lys Met 
        915                 920                 925             


Lys Lys Leu Leu Met Glu Asp Ile Pro Asp Gln Phe Ile Glu Arg Gln 
    930                 935                 940                 


Leu Asn Asp Ser Arg Tyr Ile Ser Lys Val Val Lys Ser Leu Leu Ser 
945                 950                 955                 960 


Asn Ile Val Arg Glu Glu Asn Glu Gln Glu Ala Ile Ser Lys Asn Val 
                965                 970                 975     


Ile Pro Cys Thr Gly Gly Ile Thr Asp Arg Leu Lys Lys Asp Trp Gly 
            980                 985                 990         


Ile Asn Asp Val Trp Asn Lys Ile  Val Leu Pro Arg Phe  Ile Arg Leu 
        995                 1000                 1005             


Asn Glu  Leu Thr Glu Ser Thr  Arg Phe Thr Ser Ile  Asn Thr Asn 
    1010                 1015                 1020             


Asn Thr  Met Ile Pro Ser Met  Pro Leu Glu Leu Gln  Lys Gly Phe 
    1025                 1030                 1035             


Asn Lys  Lys Arg Ile Asp His  Arg His His Ala Met  Asp Ala Ile 
    1040                 1045                 1050             


Ile Ile  Ala Cys Ala Asn Arg  Asn Ile Val Asn Tyr  Leu Asn Asn 
    1055                 1060                 1065             


Val Ser  Ala Ser Lys Asn Thr  Lys Ile Thr Arg Arg  Asp Leu Gln 
    1070                 1075                 1080             


Thr Leu  Leu Cys His Lys Asp  Lys Thr Asp Asn Asn  Gly Asn Tyr 
    1085                 1090                 1095             


Lys Trp  Val Ile Asp Lys Pro  Trp Glu Thr Phe Thr  Gln Asp Thr 
    1100                 1105                 1110             


Leu Thr  Ala Leu Gln Lys Ile  Thr Val Ser Phe Lys  Gln Asn Leu 
    1115                 1120                 1125             


Arg Val  Ile Asn Lys Thr Thr  Asn His Tyr Gln His  Tyr Glu Asn 
    1130                 1135                 1140             


Gly Lys  Lys Ile Val Ser Asn  Gln Ser Lys Gly Asp  Ser Trp Ala 
    1145                 1150                 1155             


Ile Arg  Lys Ser Met His Lys  Glu Thr Val His Gly  Glu Val Asn 
    1160                 1165                 1170             


Leu Arg  Met Ile Lys Thr Val  Ser Phe Asn Glu Ala  Leu Lys Lys 
    1175                 1180                 1185             


Pro Gln  Ala Ile Val Glu Met  Asp Leu Lys Lys Lys  Ile Leu Ala 
    1190                 1195                 1200             


Met Leu  Glu Leu Gly Tyr Asp  Thr Lys Arg Ile Lys  Asn Tyr Phe 
    1205                 1210                 1215             


Glu Glu  Asn Lys Asp Thr Trp  Gln Asp Ile Asn Pro  Ser Lys Ile 
    1220                 1225                 1230             


Lys Val  Tyr Tyr Phe Thr Lys  Glu Thr Lys Asp Arg  Tyr Phe Ala 
    1235                 1240                 1245             


Val Arg  Lys Pro Ile Asp Thr  Ser Phe Asp Lys Lys  Lys Ile Lys 
    1250                 1255                 1260             


Glu Ser  Ile Thr Asp Thr Gly  Ile Gln Gln Ile Met  Leu Arg His 
    1265                 1270                 1275             


Leu Glu  Thr Lys Asp Asn Asp  Pro Thr Leu Ala Phe  Ser Pro Asp 
    1280                 1285                 1290             


Gly Ile  Asp Glu Met Asn Arg  Asn Ile Leu Ile Leu  Asn Lys Gly 
    1295                 1300                 1305             


Lys Lys  His Gln Pro Ile Tyr  Lys Val Arg Val Tyr  Glu Lys Ala 
    1310                 1315                 1320             


Glu Lys  Phe Thr Val Gly Gln  Lys Gly Asn Lys Arg  Thr Lys Phe 
    1325                 1330                 1335             


Val Glu  Ala Ala Lys Gly Thr  Asn Leu Phe Phe Ala  Ile Tyr Glu 
    1340                 1345                 1350             


Thr Glu  Glu Ile Asp Lys Asp  Thr Lys Lys Val Ile  Arg Lys Arg 
    1355                 1360                 1365             


Ser Tyr  Ser Thr Ile Pro Leu  Asn Val Val Ile Glu  Arg Gln Lys 
    1370                 1375                 1380             


Gln Gly  Leu Ser Ser Ala Pro  Glu Asp Glu Asn Gly  Asn Leu Pro 
    1385                 1390                 1395             


Lys Tyr  Ile Leu Ser Pro Asn  Asp Leu Val Tyr Val  Pro Thr Gln 
    1400                 1405                 1410             


Glu Glu  Ile Asn Lys Gly Glu  Val Val Met Pro Ile  Asp Arg Asp 
    1415                 1420                 1425             


Arg Ile  Tyr Lys Met Val Asp  Ser Ser Gly Ile Thr  Ala Asn Phe 
    1430                 1435                 1440             


Ile Pro  Ala Ser Thr Ala Asn  Leu Ile Phe Ala Leu  Pro Lys Ala 
    1445                 1450                 1455             


Thr Ala  Glu Ile Tyr Cys Asn  Gly Glu Asn Cys Ile  Gln Asn Glu 
    1460                 1465                 1470             


Tyr Gly  Ile Gly Ser Pro Gln  Ser Lys Asn Gln Lys  Ala Ile Thr 
    1475                 1480                 1485             


Gly Glu  Met Val Lys Glu Ile  Cys Phe Pro Ile Lys  Val Asp Arg 
    1490                 1495                 1500             


Leu Gly  Asn Ile Ile Gln Val  Gly Ser Cys Ile Leu  Thr Asn 
    1505                 1510                 1515         


<210> 84
<211> 1424
<212> PRT
<213> Bacteroides sp.


<220>
<223> Bacteroides sp. 3_1_19

<400> 84
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Glu Thr Asp Glu Glu Val Ser Ser Ile Ile 
            20                  25                  30          


Arg Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Thr Gln Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Glu Arg Thr Leu Lys 
    50                  55                  60                  


Arg Ser Met Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Asp Ala 
65                  70                  75                  80  


Leu Val Glu Phe Leu Lys Glu Leu Gly Phe Ile Thr Asp Glu Thr Ile 
                85                  90                  95      


Leu Ser Glu Gln Gly Asn Arg Thr Thr Phe Glu Thr Cys Arg Leu Arg 
            100                 105                 110         


Ala Lys Ala Ala Glu Glu Glu Ile Ser Leu Glu Glu Leu Ser Arg Val 
        115                 120                 125             


Leu Leu Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Val 
    130                 135                 140                 


Lys Lys Glu Glu Asp Gly Val Leu Ile Asp Gly Met Glu Ile Ala Lys 
145                 150                 155                 160 


Lys Leu Tyr Glu Glu Asp Leu Thr Pro Gly Gln Leu Cys Ser Gln Leu 
                165                 170                 175     


Leu Glu Ser Gly Lys Lys Val Leu Pro Asp Phe Tyr His Ser Asp Leu 
            180                 185                 190         


Gln Glu Glu Leu Asp Arg Ile Trp Ser Val Gln Lys Gln Phe His Pro 
        195                 200                 205             


Asp Val Phe Cys Asp Ala Ala Lys Glu Glu Ile Lys Gly Lys Asn Arg 
    210                 215                 220                 


Ser Gln Thr Trp Ala Ile Leu Ala Asn Tyr Phe Val Trp Lys Glu Glu 
225                 230                 235                 240 


Val Val Gly Trp Asn Asp Arg Glu Ala Lys Asn Glu Thr Ile Glu Lys 
                245                 250                 255     


Glu Cys Lys Leu Val Gly Leu Lys Arg Thr Thr Lys Gly Tyr Glu Leu 
            260                 265                 270         


Lys Lys Glu Asn Tyr Arg Trp Arg Ala Gln Ala Leu Thr Glu Gln Leu 
        275                 280                 285             


Gly Leu Glu Glu Ile Ala Val Val Leu Gln Glu Ile Asn Gly Gln Ile 
    290                 295                 300                 


Asn Ala Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Val 
305                 310                 315                 320 


Leu Tyr Phe Asn His Gln Thr Val Gly Gln Tyr Gln Met Ala Glu Leu 
                325                 330                 335     


Asp Lys Asn Pro His Ala Ser Leu Arg Asn Met Val Phe Tyr Arg Gln 
            340                 345                 350         


Asp Tyr Leu Asp Glu Phe Asp Arg Ile Trp Glu Lys Gln Ala Glu Phe 
        355                 360                 365             


His Lys Glu Leu Thr Ala Glu Leu Lys Lys Glu Ile Arg Asp Met Ile 
    370                 375                 380                 


Ile Phe Tyr Gln Arg Arg Leu Lys Ser Gln Lys Gly Leu Ile Ser Phe 
385                 390                 395                 400 


Cys Glu Phe Glu Arg Leu Glu Ile Val Val Glu Lys Asp Gly Lys Lys 
                405                 410                 415     


Gln Thr Lys Val Ile Gly Cys Lys Val Ile Pro Arg Ser His Pro Leu 
            420                 425                 430         


Phe Gln Glu Phe Lys Val Trp Gln Thr Leu Asn Asp Ile Lys Val Leu 
        435                 440                 445             


Gly Arg Glu Lys Lys Arg Asn Ala Leu Ser Ala Ser Glu Ser Arg Ala 
    450                 455                 460                 


Leu Tyr Pro Glu Glu Lys Glu Ile Leu Ala Arg Glu Leu Ala Ile Lys 
465                 470                 475                 480 


Glu Asn Met Lys Lys Ala Asp Val Leu Lys Leu Leu Phe Glu Asn Pro 
                485                 490                 495     


Gln Glu Leu Asp Leu Asn Phe Lys Gln Ile Asp Gly Asn Arg Thr Gly 
            500                 505                 510         


Phe Ser Leu Phe Ser Ala Tyr Ser Lys Met Ile Glu Lys Tyr Gly Tyr 
        515                 520                 525             


Glu Pro Leu Asp Phe Lys Lys Pro Ala Asp Glu Ile Ile Gly Gln Leu 
    530                 535                 540                 


Arg Thr Ile Phe Thr Asp Leu Gly Trp Asn Thr Asn Leu Phe Thr Ile 
545                 550                 555                 560 


Asp Leu Thr Lys Glu Gly Lys Glu Leu Glu Met Gln Pro Tyr Phe Arg 
                565                 570                 575     


Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Ser Thr Gly 
            580                 585                 590         


Asn Gly Lys Leu Ile Glu Lys Ile Met Gln Leu Cys Gly Val Glu Lys 
        595                 600                 605             


Glu Tyr Ala Val Glu Leu Ala Ser Leu Ser Phe Gln Asp Asp Tyr Gly 
    610                 615                 620                 


Ser Leu Ser Ala Lys Ala Ile Lys Arg Ile Leu Pro Tyr Leu Lys Glu 
625                 630                 635                 640 


Gly Asn Leu Tyr Asp Val Ala Cys Glu Tyr Ala Gly Tyr Arg His Ser 
                645                 650                 655     


Lys Ser Ser Leu Thr Lys Glu Glu Ile Glu Asn Lys Val Leu Lys Gly 
            660                 665                 670         


Lys Leu Glu Val Leu Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu 
        675                 680                 685             


Lys Ile Leu Ser Gln Met Val Asn Val Ile Asn Thr Ile Ile Asp Thr 
    690                 695                 700                 


Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 
705                 710                 715                 720 


Lys Ser Ala Lys Glu Arg Glu Glu Leu Thr Lys Ala Ile Ala Lys Ser 
                725                 730                 735     


Thr Arg Glu His Glu Glu Ile Arg Lys Leu Leu Gln Asp Glu Phe Gly 
            740                 745                 750         


Met Met Asn Val Ser Arg Asn Asp Ile Ile Arg Tyr Lys Leu Tyr Glu 
        755                 760                 765             


Glu Leu Lys Asp Asn Gly Tyr Lys Thr Leu Tyr Ser Asn Gln Tyr Ile 
    770                 775                 780                 


Pro Lys Glu Lys Ile Phe Ser Lys Glu Ile Asp Ile Glu His Ile Ile 
785                 790                 795                 800 


Pro Gln Ser Arg Leu Phe Asp Asp Ser Leu Ser Asn Lys Thr Leu Glu 
                805                 810                 815     


Tyr Lys Ala Ile Asn Ile Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe 
            820                 825                 830         


Val Lys Glu Lys Tyr Gly Glu Glu Gly Leu Gln Gln Tyr Ile Asn Arg 
        835                 840                 845             


Cys Glu Ser Leu Phe Asn Asp Lys Lys Ala Lys Leu Arg Lys Leu Lys 
    850                 855                 860                 


Met Glu Gln Lys Asp Ile Pro Asp Gly Phe Ile Asp Arg Asp Leu Arg 
865                 870                 875                 880 


Asn Thr Gln Tyr Ile Ala Lys Lys Ala Leu Ala Met Leu Asn Glu Ile 
                885                 890                 895     


Cys Arg Arg Val Val Ala Thr Thr Gly Ser Ile Thr Asp Gln Leu Arg 
            900                 905                 910         


Glu Asp Trp Gln Leu Val Asp Val Met Lys Glu Leu Asn Leu Pro Lys 
        915                 920                 925             


Tyr Glu Ala Leu Gly Phe Val Glu Thr Tyr Glu Asp Lys Asp Gly Arg 
    930                 935                 940                 


Lys Ile Lys Arg Ile Lys Asp Trp Thr Lys Arg Asn Asp His Arg His 
945                 950                 955                 960 


His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Lys Asp Ala Phe Ile 
                965                 970                 975     


Gln Tyr Phe Asn Asn Lys Asn Ala Ala Gln Asp Ser Gly Asn Arg Asn 
            980                 985                 990         


His Thr Asn Ile Ile Gly Ile Lys  Thr Arg Tyr Phe Asp  Lys Gly Arg 
        995                 1000                 1005             


Ala Leu  Pro Pro Ile Pro Leu  Glu Gln Phe Arg Ile  Glu Ala Lys 
    1010                 1015                 1020             


Gln His  Leu Glu Lys Leu Leu  Val Ser Ile Lys Ala  Lys Asn Lys 
    1025                 1030                 1035             


Val Val  Thr Val Asn Val Asn  Arg Thr Lys Lys Arg  Lys Gly Glu 
    1040                 1045                 1050             


Asn Thr  Lys Ile Gln Gln Thr  Pro Arg Gly Gln Leu  His Leu Glu 
    1055                 1060                 1065             


Thr Val  Tyr Gly Ser His Lys  Gln Tyr Val Thr Lys  Ile Glu Lys 
    1070                 1075                 1080             


Val Asn  Ala Ser Phe Asp Ala  Ala Lys Ile Ala Thr  Val Ser Lys 
    1085                 1090                 1095             


Arg Ala  Tyr Arg Asn Ala Leu  Leu Lys Arg Leu Glu  Thr Phe Gly 
    1100                 1105                 1110             


Asn Asp  Pro Lys Lys Ala Phe  Thr Gly Lys Asn Ala  Leu Glu Lys 
    1115                 1120                 1125             


Asn Pro  Leu Tyr Ala Asp Lys  Tyr Gln Thr Ile Arg  Val Pro Glu 
    1130                 1135                 1140             


Lys Val  Gln Thr Val Glu Phe  Glu Thr Ile Tyr Thr  Ile Arg Lys 
    1145                 1150                 1155             


Pro Val  Asp Pro Ala Leu Asn  Val Asp Lys Val Val  Asp Val Lys 
    1160                 1165                 1170             


Val Arg  Ala Ile Leu Glu Arg  Arg Leu Lys Glu Tyr  Gly Gly Asp 
    1175                 1180                 1185             


Pro Lys  Lys Ala Phe Val Asn  Phe Trp Glu Asn Pro  Ile Trp Leu 
    1190                 1195                 1200             


Asn Lys  Glu Lys Gly Ile Ser  Ile Lys Arg Val Ser  Ile Arg Gly 
    1205                 1210                 1215             


Ile Asn  Asn Ala Gln Ser Ile  His Val Lys Lys Asp  Lys Asn Gly 
    1220                 1225                 1230             


Asn Pro  Ile Trp Asp Glu Asn  Gly Lys Gln Ile Pro  Val Asp Phe 
    1235                 1240                 1245             


Val Asn  Thr Gly Asn Asn His  His Val Ala Ile Tyr  Arg Lys Pro 
    1250                 1255                 1260             


Val Leu  Asp Lys Lys Gly Gln  Val Thr Phe Asp Glu  Asp Gly Asn 
    1265                 1270                 1275             


Leu Met  Tyr Glu Leu Asp Glu  Val Val Val Pro Phe  Phe Glu Ala 
    1280                 1285                 1290             


Val Thr  Arg Ala Asn Leu Gly  Leu Pro Ile Ile Asp  Lys Asp Tyr 
    1295                 1300                 1305             


Arg Lys  Ser Glu Gly Trp Gln  Phe Leu Phe Ser Met  Lys Gln Asn 
    1310                 1315                 1320             


Glu Tyr  Phe Val Phe Pro Asn  Glu Lys Thr Gly Phe  Asn Pro Lys 
    1325                 1330                 1335             


Glu Val  Asp Leu Leu Asn Pro  Asp Asn Tyr Ala Met  Ile Ser Pro 
    1340                 1345                 1350             


Asn Leu  Phe Arg Val Gln Thr  Met Ser Lys Val Met  Tyr Gly Asn 
    1355                 1360                 1365             


Asn Val  Val Arg Asp Tyr Lys  Phe Arg His His Leu  Glu Thr Thr 
    1370                 1375                 1380             


Val Lys  Asp Met Lys Glu Leu  Lys Asp Ile Ala Tyr  Lys Gln Tyr 
    1385                 1390                 1395             


Lys Thr  Leu Ser Phe Gly Asn  Ser Val Val Lys Ile  Arg Ile Asn 
    1400                 1405                 1410             


His Ile  Gly Gln Ile Val Ser  Val Gly Glu Tyr 
    1415                 1420                 


<210> 85
<211> 1510
<212> PRT
<213> Bacteroides sp.


<220>
<223> Bacteroides sp. D2

<400> 85
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asp Ser Glu Glu Gln Arg Ile Leu Gly Met Gly Ser Arg 
            20                  25                  30          


Ile Ile Pro Met Asp Gln Gly Val Leu Asp Thr Phe Ser Gly Gly Asn 
        35                  40                  45              


Pro Val Glu Thr Gln Thr Ala Ala Arg Thr Ala Tyr Arg Gly Thr Arg 
    50                  55                  60                  


Arg Leu Arg Glu Arg Ala Leu Leu Arg Arg Glu Arg Leu Ile Arg Val 
65                  70                  75                  80  


Leu Asn Met Met Lys Phe Leu Pro Glu His Tyr Ala Ser Gln Ile Asp 
                85                  90                  95      


Phe Glu Lys Arg Leu Gly Gln Phe Phe Asp Glu Lys Glu Pro Lys Leu 
            100                 105                 110         


Ala Trp Lys Gln Asn Asp Glu Gly Arg Phe Glu Phe Ile Phe Gln Gln 
        115                 120                 125             


Ser Phe Asn Glu Met Ile Glu Glu Phe Lys Asn Lys Gly Val Val Arg 
    130                 135                 140                 


Glu Asp Lys Lys Ile Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys 
145                 150                 155                 160 


Lys Ala Leu Ser Gln Glu Ile Glu Lys Glu Glu Leu Ala Trp Ile Leu 
                165                 170                 175     


Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu 
            180                 185                 190         


Glu Glu Glu Asn Pro Asn Lys Leu Val Glu Tyr Tyr Ser Leu Lys Ile 
        195                 200                 205             


Val Asp Val Ile Ala Asp Glu Lys Pro Asn Ser Lys Gly Asp Ile Trp 
    210                 215                 220                 


Tyr Ser Leu His Leu Glu Asn Gly Trp Ile Tyr Arg Arg Ser Ser Lys 
225                 230                 235                 240 


Ile Pro Leu Phe Gly Trp Lys Asp Lys Thr Arg Asp Phe Ile Val Thr 
                245                 250                 255     


Thr Asp Leu Asn Asp Asp Gly Thr Val Lys Lys Asp Lys Glu Gly Ile 
            260                 265                 270         


Glu Lys Arg Ser Phe Arg Ala Pro Ser Glu Asn Asp Trp Val Leu Leu 
        275                 280                 285             


Lys Lys Lys Thr Glu Ser Asp Ile Glu Lys Ser His Lys Thr Val Gly 
    290                 295                 300                 


Ala Tyr Val Tyr Glu Thr Leu Leu Gln Asn Pro Met Gln Lys Val Arg 
305                 310                 315                 320 


Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Phe Tyr Lys Asp Glu Leu 
                325                 330                 335     


Lys Gln Ile Leu Glu Lys Gln Arg Glu Phe His Pro Glu Leu Arg Asp 
            340                 345                 350         


Glu Asp Leu Tyr Asn Asp Cys Val Arg Glu Leu Tyr Arg Ser Asn Glu 
        355                 360                 365             


Thr Tyr Gln Phe Ile Leu Ser Lys Arg Asp Phe Val His Leu Phe Leu 
    370                 375                 380                 


Asp Asp Ile Leu Phe Tyr Gln Arg Pro Leu Arg Ser Gln Lys Ser Ala 
385                 390                 395                 400 


Ile Gly Asp Cys Ile Leu Glu Phe Lys Thr Tyr Lys Asp Lys Asp Gly 
                405                 410                 415     


Asn Asn Ile Lys Glu Tyr Leu Lys Val Ile Ser Lys Ser Asn Pro Leu 
            420                 425                 430         


Tyr Gln Glu Phe Arg Ile Trp Gln Trp Leu Tyr Asn Leu Lys Ile Tyr 
        435                 440                 445             


Arg Lys Glu Asp Asp Glu Asp Val Thr Leu Gln Phe Ile Ala Asn Ile 
    450                 455                 460                 


Glu Asp Lys Glu Gln Leu Phe Asp Phe Leu Ser Asn Arg Lys Ser Ile 
465                 470                 475                 480 


Glu Gln Lys Pro Leu Leu Glu Tyr Leu Ile Lys Ala Lys Gly Leu Lys 
                485                 490                 495     


Lys Gln Val Lys Thr Glu Ala Tyr Arg Trp Asn Tyr Val Glu Asp Lys 
            500                 505                 510         


Ile Tyr Pro Cys Ser Glu Thr Lys Thr Met Ile Ser Thr Arg Leu Ala 
        515                 520                 525             


Lys Val Glu Asn Ile Pro Asp Asn Phe Phe Thr Lys Glu Ile Glu Gln 
    530                 535                 540                 


Lys Leu Trp His Ile Ile Tyr Ser Val Thr Asp Lys Asn Glu Phe Glu 
545                 550                 555                 560 


Lys Ala Leu Arg Thr Phe Ala Lys Lys Tyr Asp Leu Asp Ile Ala Ser 
                565                 570                 575     


Phe Val Asp Asn Phe Lys Lys Ile Pro Pro Phe Lys Asn Glu Tyr Gly 
            580                 585                 590         


Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro Leu Met Arg Leu 
        595                 600                 605             


Gly Lys Tyr Trp Lys Trp Asn Asp Ile Asp Asn Asn Thr Gln Asn Arg 
    610                 615                 620                 


Ile Ser Lys Ile Ile Thr Gly Glu Tyr Asp Glu Glu Ile Lys Asp Ile 
625                 630                 635                 640 


Val Arg Glu Lys Ser Ile Ala Leu Thr Asn Glu Asn Asp Phe Gln Gly 
                645                 650                 655     


Leu Gln Leu Trp Leu Ala Gln Tyr Leu Val Tyr Gly Arg His Ser Glu 
            660                 665                 670         


Ala Asp Ile Ala Gly Lys Trp His Ser Val Ala Asp Leu Glu Lys Tyr 
        675                 680                 685             


Leu Asn Glu Phe Lys Gln His Ser Leu Arg Asn Pro Ile Val Glu Gln 
    690                 695                 700                 


Ile Ile Thr Glu Thr Leu Arg Val Val Arg Asp Ile Trp Arg Lys Tyr 
705                 710                 715                 720 


Gly Gln Gly Ala Glu Asn Phe Phe Ser Glu Ile His Val Glu Leu Gly 
                725                 730                 735     


Arg Asp Met Lys Asn Thr Ala Asp Glu Arg Lys Lys Ile Val Asn Val 
            740                 745                 750         


Val Thr Glu Asn Glu Asn Thr Asn Leu Arg Ile Lys Ala Leu Leu Met 
        755                 760                 765             


Glu Leu Lys Asn Asn Ser Asp Gly Lys Leu Glu Val Glu Asn Val Arg 
    770                 775                 780                 


Pro Tyr Ser Pro Thr Gln Gln Asp Ile Leu Lys Ile Tyr Glu Glu Tyr 
785                 790                 795                 800 


Ala Ile Ser Thr Gly Leu Asp Asn Glu Lys Asp Glu Lys Val Lys Glu 
                805                 810                 815     


Asp Ile Lys Lys Ile Ser Arg Val Ala Gln Pro Thr Thr Thr Glu Leu 
            820                 825                 830         


Gln Arg Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Cys Ser Pro Tyr Thr 
        835                 840                 845             


Gly Lys Val Ile Pro Leu Gly Lys Leu Phe Thr Glu Glu Tyr Gln Ile 
    850                 855                 860                 


Glu His Ile Ile Pro Lys Ser Arg Tyr Tyr Asp Asp Ser Phe Ser Asn 
865                 870                 875                 880 


Lys Val Ile Cys Glu Ala Ala Val Asn Lys Leu Lys Asp Lys Cys Leu 
                885                 890                 895     


Gly Leu Glu Phe Ile Lys Asn Tyr His Gly Gln Ile Val Glu Thr Gly 
            900                 905                 910         


Phe Gly Gln Lys Val Thr Ile Phe Asp Glu Glu Ala Tyr Gln Asn Phe 
        915                 920                 925             


Val Lys Gln His Tyr Ala Tyr Asn Arg Ser Lys Arg Thr Lys Leu Leu 
    930                 935                 940                 


Leu Glu Glu Ile Pro Glu Lys Met Ile Glu Arg Gln Met Asn Asp Thr 
945                 950                 955                 960 


Arg Tyr Ile Ser Lys Phe Val Leu Pro Leu Leu Ser Asn Leu Val Arg 
                965                 970                 975     


Ala Glu Glu Asn Asp Asn Gly Val Asn Ser Lys Asn Val Leu Pro Val 
            980                 985                 990         


Asn Gly Lys Ile Thr Thr Met Leu  Lys Gln Asp Trp Gly  Leu Asn Asp 
        995                 1000                 1005             


Val Trp  Asn Asp Leu Ile Leu  Pro Arg Phe Val Arg  Met Asn Glu 
    1010                 1015                 1020             


Leu Ala  Lys Thr Ile Ala Phe  Thr Ser Trp Asn Glu  Gln His Gln 
    1025                 1030                 1035             


Lys Tyr  Leu Pro Thr Val Pro  Leu Glu Leu Ser Lys  Gly Phe Gln 
    1040                 1045                 1050             


Lys Lys  Arg Ile Asp His Arg  His His Ala Met Asp  Ala Leu Val 
    1055                 1060                 1065             


Ile Ala  Cys Ala Thr Arg Asp  His Val Asn Leu Leu  Asn Asn Lys 
    1070                 1075                 1080             


His Ala  Asn Thr Asp Thr Ile  Arg Tyr Asp Leu Gln  Arg Lys Leu 
    1085                 1090                 1095             


Arg Leu  Phe Glu Arg Val Thr  Tyr Ile Asp Pro Gln  Thr Lys Asn 
    1100                 1105                 1110             


Asn Val  Thr Lys Asp Ile Pro  Lys Glu Phe Lys Lys  Pro Trp Asp 
    1115                 1120                 1125             


Asn Phe  Thr Val Asp Ala Arg  Asn Glu Leu Glu Lys  Ile Ile Val 
    1130                 1135                 1140             


Ser Phe  Lys Gln Asn Leu Arg  Ile Ile Asn Lys Ala  Thr Asn Ile 
    1145                 1150                 1155             


Tyr Thr  Lys Tyr Glu Asn Gly  Lys Lys Ile Lys Val  Gly Gln Lys 
    1160                 1165                 1170             


Gly Leu  Asn Trp Ala Ile Arg  Lys Pro Leu His Lys  Glu Thr Val 
    1175                 1180                 1185             


Phe Ala  Lys Val Ser Leu Arg  Lys Arg Lys Thr Val  Arg Leu Ser 
    1190                 1195                 1200             


Glu Ala  Leu Lys Asp Trp Lys  Lys Ile Val Asp Lys  Lys Leu Lys 
    1205                 1210                 1215             


Gln Glu  Ile Lys Arg Leu Thr  Cys Gln Tyr Gly Lys  Phe Asp Val 
    1220                 1225                 1230             


Asp Thr  Ile Leu Arg Tyr Phe  Lys Asp Arg Lys Tyr  Gln Phe Gly 
    1235                 1240                 1245             


Glu Val  Asp Val Ser Lys Val  Lys Met Tyr Tyr Phe  Asp Glu Glu 
    1250                 1255                 1260             


Asn Ala  Ala Val Arg Lys Asn  Val Asp Thr Ser Phe  Thr Glu Lys 
    1265                 1270                 1275             


Phe Ile  Gln Gly Ser Val Thr  Asp Thr Gly Ile Gln  Lys Ile Leu 
    1280                 1285                 1290             


Leu Asn  His Leu Glu Ala Lys  Gly Asn Lys Val Glu  Ile Ala Phe 
    1295                 1300                 1305             


Ser Pro  Glu Gly Ile Glu Glu  Met Asn Lys Asn Ile  Ile Gln Leu 
    1310                 1315                 1320             


Asn Glu  Gly Lys Leu His Leu  Pro Ile Phe Lys Val  Arg Val Tyr 
    1325                 1330                 1335             


Glu Thr  Ile Gly Asn Lys Phe  Ser Val Gly Val Lys  Gly Asn Lys 
    1340                 1345                 1350             


Lys Asp  Lys Tyr Val Glu Ala  Ala Lys Gly Thr Asn  Leu Phe Phe 
    1355                 1360                 1365             


Ala Ile  Tyr Val Asp Glu Asn  Gly Ile Arg Ser Tyr  Glu Thr Ile 
    1370                 1375                 1380             


Pro Leu  Asn Ile Val Ile Glu  Arg Leu Lys Gln Gly  Leu Ser Val 
    1385                 1390                 1395             


Val Pro  Glu Lys Asn Arg Lys  Glu His Ser Leu Leu  Phe Tyr Leu 
    1400                 1405                 1410             


Ser Pro  Asn Asp Leu Val Tyr  Val Pro Ile Glu Asp  Glu Arg Glu 
    1415                 1420                 1425             


Asn Ile  His Ala Val Asn Leu  Asp Gln Leu Asn Asn  Glu Gln Arg 
    1430                 1435                 1440             


Lys Arg  Ile Tyr Lys Met Val  Ser Cys Thr Gly Ser  Glu Cys His 
    1445                 1450                 1455             


Phe Val  Pro Tyr Tyr Val Ala  Ser Pro Ile Val Asn  Lys Val Glu 
    1460                 1465                 1470             


Tyr Ser  Ser Leu Asn Lys Ile  Gly Arg Ser Leu Thr  Gly Glu Met 
    1475                 1480                 1485             


Ile Lys  Asp Val Cys Ile Lys  Leu Lys Val Asp Arg  Leu Gly Asn 
    1490                 1495                 1500             


Val Lys  Gly Ile Ser Gly Leu  
    1505                 1510 


<210> 86
<211> 1436
<212> PRT
<213> Bacteroides sp.


<220>
<223> Bacteroides sp. D2

<400> 86
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asp Glu Ala Glu Asn Lys Asp Glu Arg Ser Ser Ile Val 
            20                  25                  30          


Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Leu Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Met Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Glu Thr 
65                  70                  75                  80  


Leu Met Glu Val Leu Lys Glu His Lys Leu Ile Thr Glu Asp Thr Ile 
                85                  90                  95      


Leu Ser Glu Asn Gly Asn Arg Thr Thr Phe Glu Thr Tyr Arg Leu Arg 
            100                 105                 110         


Ala Lys Ala Ala Thr Glu Lys Ile Ser Leu Glu Glu Phe Ala Arg Val 
        115                 120                 125             


Leu Leu Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Cys Arg Lys Ala 
    130                 135                 140                 


Lys Gly Ala Glu Glu Gly Thr Leu Ile Asp Gly Met Asp Ile Ala Arg 
145                 150                 155                 160 


Glu Leu Tyr Asn Asn Asn Leu Thr Pro Gly Glu Leu Cys Leu Gln Leu 
                165                 170                 175     


Leu Asp Ala Gly Lys Lys Tyr Leu Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Asn Glu Leu Asp Arg Ile Trp Glu Lys Gln Lys Glu Tyr Tyr Pro 
        195                 200                 205             


Glu Ile Leu Thr Glu Val Leu Lys Glu Glu Leu Arg Gly Lys Lys Arg 
    210                 215                 220                 


Asp Ala Val Trp Ala Ile Cys Ala Lys Ser Phe Val Trp Glu Glu Tyr 
225                 230                 235                 240 


Tyr Thr Glu Trp Asn Lys Glu Lys Gly Lys Thr Glu Gln Gln Glu Arg 
                245                 250                 255     


Glu His Lys Leu Glu Gly Ile Tyr Ser Lys Arg Lys Arg Asp Glu Ala 
            260                 265                 270         


Lys Arg Glu Asn Leu Gln Trp Arg Val Asn Gly Leu Lys Glu Lys Leu 
        275                 280                 285             


Ser Leu Glu Gln Leu Val Ile Val Leu Gln Glu Met Asn Ile Gln Ile 
    290                 295                 300                 


Asn Asn Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Glu 
305                 310                 315                 320 


Leu Tyr Phe Asn Lys Gln Thr Val Gly Gln Tyr Gln Met Glu Met Leu 
                325                 330                 335     


Asp Lys Asn Pro Asn Ala Ser Leu Arg Asn Met Val Phe Tyr Arg Gln 
            340                 345                 350         


Asp Tyr Leu Asp Glu Phe Asn Thr Leu Trp Glu Lys Gln Ala Glu Tyr 
        355                 360                 365             


His Lys Glu Leu Thr Gly Glu Leu Lys Lys Glu Ile Arg Asp Ile Val 
    370                 375                 380                 


Ile Phe Tyr Gln Arg Arg Leu Lys Ser Gln Lys Gly Leu Val Gly Phe 
385                 390                 395                 400 


Cys Glu Phe Glu Ser Arg Gln Ile Glu Val Glu Ile Asp Gly Lys Lys 
                405                 410                 415     


Lys Ile Lys Thr Val Gly Asn Arg Val Ile Pro Arg Ser Ser Pro Leu 
            420                 425                 430         


Phe Gln Glu Phe Lys Ile Trp Gln Ile Leu Asn Asn Ile Glu Val Thr 
        435                 440                 445             


Val Val Gly Lys Lys Gly Lys Arg Arg Lys Gln Lys Asp Asn Ser Pro 
    450                 455                 460                 


Thr Leu Phe Asp Gly Leu Asp Asp Thr Glu Gln Leu Glu Leu Asn Gly 
465                 470                 475                 480 


Ser Arg Tyr Leu Tyr Gln Glu Glu Lys Glu Leu Leu Ala Gln Glu Leu 
                485                 490                 495     


Phe Val Arg Asp Lys Met Thr Lys Ser Asp Val Leu Lys Leu Leu Phe 
            500                 505                 510         


Asp Asn Pro Gln Glu Leu Asp Leu Asn Phe Lys Thr Ile Asp Gly Asn 
        515                 520                 525             


Lys Thr Gly Tyr Thr Leu Phe Gln Ala Tyr Ser Lys Met Ile Glu Met 
    530                 535                 540                 


Ser Gly His Glu Pro Val Asp Phe Lys Lys Thr Val Glu Lys Val Val 
545                 550                 555                 560 


Glu His Val Lys Ala Val Phe Asp Leu Leu Asn Trp Asn Thr Asp Ile 
                565                 570                 575     


Leu Gly Phe Asn Ser Asn Glu Glu Leu Asp Asn Gln Ser Tyr Tyr Lys 
            580                 585                 590         


Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Pro Thr Gly 
        595                 600                 605             


Asn Ala Arg Leu Val Gln Lys Ile Thr Glu Leu Tyr Gly Phe Glu Lys 
    610                 615                 620                 


Glu Tyr Ala Ile Ile Leu Ala Asn Val Thr Phe Gln Asp Asp Tyr Gly 
625                 630                 635                 640 


Ser Leu Ser Ala Lys Ala Ile His Lys Ile Leu Pro His Leu Lys Glu 
                645                 650                 655     


Gly Asn Arg Tyr Asp Val Ala Cys Ala Tyr Ala Gly Tyr Lys His Ser 
            660                 665                 670         


Glu Ser Ser Leu Thr Lys Glu Glu Ile Ala Asn Lys Ala Leu Lys Asp 
        675                 680                 685             


Arg Leu Thr Leu Leu Pro Lys Asn Asn Leu Arg Asn Pro Val Val Glu 
    690                 695                 700                 


Lys Ile Leu Asn Gln Met Val Asn Val Ile Asn Ala Ile Ile Asp Thr 
705                 710                 715                 720 


Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 
                725                 730                 735     


Lys Asn Ala Lys Glu Arg Glu Glu Leu Thr Lys Phe Ile Ala Glu Thr 
            740                 745                 750         


Thr Arg Lys His Glu Glu Phe Lys Ile Leu Leu Gln Ser Glu Phe Gly 
        755                 760                 765             


Leu Thr Asn Val Ser Arg Thr Asp Ile Leu Arg Tyr Lys Leu Tyr Lys 
    770                 775                 780                 


Glu Leu Glu Ser Cys Gly Tyr Lys Thr Leu Tyr Ser Asn Thr Tyr Ile 
785                 790                 795                 800 


Pro Arg Glu Lys Leu Phe Ser Lys Glu Phe Asp Ile Glu His Ile Ile 
                805                 810                 815     


Pro Gln Ala Arg Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Glu 
            820                 825                 830         


Ala Arg Ser Ile Asn Leu Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe 
        835                 840                 845             


Val Lys Glu Lys Phe Gly Glu Ser Gly Ala Asp Asn Ser Leu Asp His 
    850                 855                 860                 


Tyr Leu Asn Asn Ile Glu Asp Leu Phe Lys Ser Gly Lys Ile Ser Lys 
865                 870                 875                 880 


Thr Lys Tyr Asn Lys Leu Lys Met Ala Glu Gln Asp Ile Pro Asp Gly 
                885                 890                 895     


Phe Ile Asn Arg Asp Leu Arg Asn Thr Gln Tyr Ile Ala Lys Lys Ala 
            900                 905                 910         


Leu Ser Met Leu Asn Glu Ile Ser Arg Arg Val Val Ala Thr Ser Gly 
        915                 920                 925             


Thr Ile Thr Asp Lys Leu Arg Gln Asp Trp Gln Leu Val Asp Val Met 
    930                 935                 940                 


Lys Glu Leu Asn Trp Glu Lys Tyr Lys Ala Leu Gly Leu Val Glu Tyr 
945                 950                 955                 960 


Phe Glu Asp Lys Asp Gly Arg Gln Ile Gly Arg Ile Lys Asp Trp Thr 
                965                 970                 975     


Lys Arg Asn Asp His Arg His His Ala Met Asp Ala Leu Thr Val Ala 
            980                 985                 990         


Phe Thr Lys Asp Ile Phe Ile Gln  Tyr Phe Asn Asn Lys  Asn Ala Ser 
        995                 1000                 1005             


Leu Asn  Ser Asn Thr Asn Glu  Tyr Ala Ile Lys Asn  Lys Tyr Phe 
    1010                 1015                 1020             


Gln Asn  Gly Arg Ala Ile Ala  Pro Ile Pro Leu Arg  Glu Phe Arg 
    1025                 1030                 1035             


Val Glu  Ala Lys Lys His Leu  Glu Asn Thr Leu Ile  Ser Ile Lys 
    1040                 1045                 1050             


Ala Lys  Asn Lys Val Val Thr  Gly Asn Ile Asn Lys  Thr Lys Lys 
    1055                 1060                 1065             


Arg Gly  Gly Val Asn Lys Tyr  Leu Gln Gln Thr Pro  Arg Gly Gln 
    1070                 1075                 1080             


Leu His  Leu Glu Thr Ile Tyr  Gly Ser Gly Lys Gln  Tyr Leu Thr 
    1085                 1090                 1095             


Lys Glu  Glu Lys Val Asn Ala  Ser Phe Asp Met Lys  Lys Ile Ala 
    1100                 1105                 1110             


Thr Val  Ser Lys Ser Ala Tyr  Arg Asp Val Leu Leu  Lys Arg Leu 
    1115                 1120                 1125             


His Glu  Asn Asp Asn Asp Pro  Lys Lys Ala Phe Thr  Gly Lys Asn 
    1130                 1135                 1140             


Ser Leu  Asp Lys Gln Pro Ile  Trp Leu Asp Lys Glu  Gln Thr Arg 
    1145                 1150                 1155             


Lys Val  Pro Glu Lys Val Lys  Thr Val Thr Leu Glu  Thr Ile Tyr 
    1160                 1165                 1170             


Thr Val  Arg Lys Glu Ile Ser  Pro Asp Leu Lys Val  Asp Lys Val 
    1175                 1180                 1185             


Ile Asp  Ala Gly Val Arg Lys  Ile Leu Thr Gly Arg  Leu Asn Glu 
    1190                 1195                 1200             


Tyr Gly  Asn Asp Ala Lys Lys  Ala Phe Ser Asn Leu  Asp Glu Asn 
    1205                 1210                 1215             


Pro Ile  Trp Leu Asn Lys Glu  Lys Gly Ile Ser Ile  Lys Arg Val 
    1220                 1225                 1230             


Thr Ile  Ser Gly Ile Ser Asn  Ala Gln Ser Leu His  Val Lys Lys 
    1235                 1240                 1245             


Asp Lys  Asp Gly Lys Pro Ile  Leu Asp Glu Asp Ser  Arg Asn Ile 
    1250                 1255                 1260             


Pro Val  Asp Phe Val Asn Thr  Gly Asn Asn His His  Val Ala Val 
    1265                 1270                 1275             


Tyr Arg  Arg Pro Val Ile Asp  Lys Arg Gly Gln Leu  Val Ile Asp 
    1280                 1285                 1290             


Glu Ala  Gly Asn Pro Lys Tyr  Glu Leu Glu Glu Val  Val Val Ser 
    1295                 1300                 1305             


Phe Phe  Glu Ala Val Thr Arg  Ala Asn Leu Gly Gln  Pro Ile Ile 
    1310                 1315                 1320             


Asp Lys  Asp Tyr Lys Thr Ser  Glu Gly Trp Gln Phe  Leu Phe Ser 
    1325                 1330                 1335             


Met Lys  Gln Asn Glu Tyr Phe  Val Phe Pro Asn Glu  Lys Thr Gly 
    1340                 1345                 1350             


Phe Asn  Pro Lys Glu Ile Asp  Leu Leu Asp Ala Glu  Asn Tyr Gly 
    1355                 1360                 1365             


Val Ile  Ser Pro Asn Leu Phe  Arg Val Gln Lys Phe  Ala His Lys 
    1370                 1375                 1380             


Asn Tyr  Val Phe Arg His His  Leu Glu Thr Thr Ile  Lys Asp Thr 
    1385                 1390                 1395             


Ser Ser  Ile Leu Lys Gly Ile  Thr Trp Ile Asp Phe  Arg Ser Ser 
    1400                 1405                 1410             


Lys Gly  Leu Asp Ala Ile Val  Lys Val Arg Val Asn  His Ile Gly 
    1415                 1420                 1425             


Gln Ile  Val Ser Val Gly Glu  Tyr 
    1430                 1435     


<210> 87
<211> 1508
<212> PRT
<213> Bacteroides uniformis


<220>
<223> Bacteroides uniformis CL03T00C23

<400> 87
Met Arg Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Ser Val Ile Lys Glu Gln Thr Glu Arg Ile Trp Ile 
            20                  25                  30          


Glu Met Ala Gly Ser Arg Ile Ile Pro Met Asp Ala Ala Ile Leu Gly 
        35                  40                  45              


Asp Phe Asp Lys Gly Asn Ser Ile Ser Gln Thr Ala Glu Arg Thr Arg 
    50                  55                  60                  


Phe Arg Gly Val Arg Arg Leu Arg Glu Arg Gln Leu Leu Arg Arg Glu 
65                  70                  75                  80  


Arg Leu His Lys Val Leu Lys Ile Leu Gly Phe Leu Pro Glu His Tyr 
                85                  90                  95      


Leu Lys Gly Ile Asp Phe Glu Lys His Thr Gly Lys Phe Leu Ser Gly 
            100                 105                 110         


Ser Glu Pro Lys Leu Pro Trp Val Lys Asp Arg Trp Gly Lys Tyr Ser 
        115                 120                 125             


Phe Leu Phe Gln Thr Ala Phe Asn Glu Met Leu Ala Asp Phe Ala Lys 
    130                 135                 140                 


His Gln Pro Ser Leu Val Phe Asp Gly Lys Lys Ile Pro Tyr Asp Trp 
145                 150                 155                 160 


Thr Val Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Glu Met Ile Ser Lys 
                165                 170                 175     


Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr 
            180                 185                 190         


Tyr Gln Leu Arg Gly Glu Glu Glu Glu Asp Asn Ala Gly Lys Ser Val 
        195                 200                 205             


Glu Phe Tyr Ala Leu Lys Val Leu Ser Val Glu Ala Thr Asp Glu Lys 
    210                 215                 220                 


Lys Gly Arg Asp Ile Trp Tyr Asn Val His Leu Glu Asn Gly Trp Val 
225                 230                 235                 240 


Tyr Arg Arg Ser Ser Asn Val Pro Leu Asp Trp Glu Gly Arg Val Lys 
                245                 250                 255     


Glu Phe Ile Val Thr Thr Asp Leu Asn Pro Asp Gly Thr Pro Lys Leu 
            260                 265                 270         


Asp Lys Tyr Gly Glu Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp 
        275                 280                 285             


Asp Trp Met Leu Ile Lys Lys Arg Thr Glu Ala Asp Ile Thr Gly Thr 
    290                 295                 300                 


His Lys Thr Ile Gly Ser Tyr Ile Tyr Asp Ala Leu Leu Gln Glu Pro 
305                 310                 315                 320 


Gln Gln Lys Ile Ile Gly Lys Leu Val Lys Thr Val Glu Arg Lys Phe 
                325                 330                 335     


Tyr Lys Glu Glu Leu Asn Phe Ile Leu Gln Lys Gln Cys Ala Phe His 
            340                 345                 350         


Ala Glu Leu Gln Asp Arg Asp Leu Tyr Met Arg Cys Ile Glu Ala Leu 
        355                 360                 365             


Tyr Pro Gly Asn Glu Val Gln Arg Arg Asn Ile Ala Asn Arg Asp Phe 
    370                 375                 380                 


Ile Tyr Leu Leu Ile Asp Asp Val Leu Phe Tyr Gln Arg Pro Leu Lys 
385                 390                 395                 400 


Thr Lys Lys Ser Leu Ile Ala Asn Cys Pro Tyr Glu Glu Asn Glu Tyr 
                405                 410                 415     


Val Asn Arg Lys Thr Gly Glu Ile Lys Thr Ala Pro Leu Lys Cys Ile 
            420                 425                 430         


Ala Lys Ser His Pro Leu Phe Gln Glu Phe Arg Leu Trp Tyr Phe Leu 
        435                 440                 445             


Ser Asn Ile Arg Val Tyr Gln Lys Glu Arg Glu Val Asn Gly Thr Leu 
    450                 455                 460                 


His Leu Asp Val Asp Val Thr Thr Glu Phe Leu Lys Thr Glu Asp Asp 
465                 470                 475                 480 


Tyr Val Ala Leu Phe Asp Trp Leu Asn Ser Arg Lys Glu Ile Asp Gln 
                485                 490                 495     


Lys Ala Phe Leu Arg Tyr Pro Ala Phe Gly Leu Lys Lys Glu Ile Asn 
            500                 505                 510         


Asn Tyr Arg Trp Asn Tyr Val Glu Asp Lys Phe Tyr Pro Cys Asn Glu 
        515                 520                 525             


Thr Arg His Ala Ile Leu Ser Arg Leu Glu Lys Ala Gly Ile Gly Ile 
    530                 535                 540                 


Asp Phe Leu Ser Asp Glu Lys Glu Thr Ala Leu Trp His Ile Leu Tyr 
545                 550                 555                 560 


Ser Val Ser Asp Lys Gln Glu Ile Glu Lys Ala Leu Ala Thr Phe Ala 
                565                 570                 575     


Val Lys Asn Gly Leu Asn Glu Ser Phe Val Glu Val Phe Lys Lys Phe 
            580                 585                 590         


Pro Pro Phe Lys Ser Glu Tyr Gly Ala Tyr Ser Ala Lys Ala Ile Lys 
        595                 600                 605             


Lys Leu Leu Pro Leu Met Arg Cys Gly Lys Tyr Trp Asp Met Ser Leu 
    610                 615                 620                 


Ile Asp Gly Thr Thr Lys Glu Arg Ile Glu Arg Ile Ile Ala Gly Glu 
625                 630                 635                 640 


Cys Asp Glu Ser Ile Gly Ala Lys Val Arg Glu Lys Ala Met Asn Leu 
                645                 650                 655     


Ser Asp Ile Ser Cys Phe Lys Arg Leu Pro Leu Trp Leu Ala Cys Tyr 
            660                 665                 670         


Val Val Tyr Asn Arg His Ser Glu Asp Lys Glu Ile Thr Lys Trp Glu 
        675                 680                 685             


Thr Pro Ala Asp Ile Asp Ala Tyr Leu Ala Ala Phe Lys Gln His Ser 
    690                 695                 700                 


Leu Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val 
705                 710                 715                 720 


Val Arg Asp Ile Trp Lys Gln Val Gly Lys Ile Asp Glu Ile Arg Ile 
                725                 730                 735     


Glu Leu Gly Arg Glu Met Lys Asn Pro Ala Asp Lys Arg Lys Arg Met 
            740                 745                 750         


Thr Thr Gln Ile Leu Glu Asn Glu Asn Ala Asn Leu Arg Ile Lys Ala 
        755                 760                 765             


Leu Leu Ala Glu Phe Val Asn Pro Glu Tyr Gly Val Glu Asn Val Arg 
    770                 775                 780                 


Pro Tyr Ser Pro Ser Gln Gln Glu Ile Leu Arg Ile Tyr Glu Asp Ala 
785                 790                 795                 800 


Val Leu Lys Gly Glu Glu Gln Ile Pro Glu Asp Ile Asp Val Ile Leu 
                805                 810                 815     


Lys Lys Phe Asn Thr Ser Lys Leu Pro Thr Lys Ser Glu Phe Leu Arg 
            820                 825                 830         


Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Glu 
        835                 840                 845             


Leu Ile Pro Leu Ala Lys Leu Phe Thr Ala Ala Tyr Glu Ile Glu His 
    850                 855                 860                 


Val Ile Pro Gln Ser Arg Tyr Phe Asp Asp Ser Phe Ser Asn Lys Val 
865                 870                 875                 880 


Ile Cys Glu Ser Ala Val Asn Lys Leu Lys Asp Asn Gln Leu Gly Tyr 
                885                 890                 895     


Glu Phe Ile Lys Asn His His Gly Gln Lys Val Glu Val Gly Phe Gly 
            900                 905                 910         


Lys Thr Val Glu Ile Phe Ser Val Asp Ser Tyr Glu Arg Phe Val Lys 
        915                 920                 925             


Glu Gln Tyr Ala Lys Ser Gly Ile Lys Met Lys Lys Leu Leu Met Asp 
    930                 935                 940                 


Asp Ile Pro Glu Gln Phe Ile Glu Arg Gln Leu Asn Asp Ser Arg Tyr 
945                 950                 955                 960 


Ile Ser Lys Val Val Lys Gly Leu Leu Ser Asn Ile Val Arg Glu Lys 
                965                 970                 975     


Asn Asp Ser Gly Glu Tyr Glu Pro Glu Ala Val Ser Lys Asn Ile Leu 
            980                 985                 990         


Val Cys Thr Gly Ser Val Thr Asp  Arg Leu Lys Lys Asp  Trp Gly Met 
        995                 1000                 1005             


Asn Asp  Val Trp Asn Ser Ile  Val Ser Pro Arg Phe  Glu Arg Leu 
    1010                 1015                 1020             


Asn Ala  Leu Thr Glu Thr Gln  Cys Phe Gly His Trp  Glu Asn Lys 
    1025                 1030                 1035             


Asp Gly  Lys Lys Val Phe Gln  Thr Ala Val Pro Leu  Glu Tyr Gln 
    1040                 1045                 1050             


Lys Gly  Phe Ser Lys Lys Arg  Ile Asp His Arg His  His Ala Met 
    1055                 1060                 1065             


Asp Ala  Ile Val Ile Ala Cys  Ala Thr Arg Asn His  Val Asn Tyr 
    1070                 1075                 1080             


Leu Asn  Asn Glu Ser Ala Ser  Arg Asn Ala Lys Ile  Ser Arg Tyr 
    1085                 1090                 1095             


Asp Leu  Gln Arg Leu Leu Cys  Asp Lys Ser Arg Gly  Asp Gly Asn 
    1100                 1105                 1110             


Gly Asn  Tyr Arg Trp Ile Ile  Lys Lys Pro Trp Thr  Thr Phe Thr 
    1115                 1120                 1125             


Gln Asp  Ala Arg Glu Ala Leu  Ser Gly Ile Ile Val  Ser Leu Lys 
    1130                 1135                 1140             


Gln Asn  Leu Arg Ile Ile Asn  Lys Thr Thr Asn Ile  Tyr Gln His 
    1145                 1150                 1155             


Phe Asp  Ala Asn Gly Thr Arg  Val Tyr Glu Lys Gln  Lys Ile Gly 
    1160                 1165                 1170             


Asp Ser  Trp Ala Ile Arg Lys  Pro Met His Lys Asp  Thr Val Phe 
    1175                 1180                 1185             


Gly Ala  Val Asn Leu Arg Lys  Val Lys Val Val Arg  Leu Ser Val 
    1190                 1195                 1200             


Ala Leu  Asp Thr Pro Ser Met  Ile Val Asn Lys Arg  Val Lys Asn 
    1205                 1210                 1215             


Lys Val  Leu Glu Leu Leu Ser  Tyr Lys Tyr Asp Lys  Lys Lys Ile 
    1220                 1225                 1230             


Glu Lys  Tyr Phe Lys Glu Asn  Ala Phe Leu Trp Lys  Glu Leu Asp 
    1235                 1240                 1245             


Ile Ala  Lys Val Ala Val Tyr  Tyr Phe Thr Glu Asn  Thr Thr Glu 
    1250                 1255                 1260             


Pro Leu  Val Ala Val Arg Lys  Ser Leu Asp Ser Thr  Phe Asn Glu 
    1265                 1270                 1275             


Lys Lys  Ile Ala Ser Val Thr  Asp Thr Gly Ile Gln  Lys Ile Leu 
    1280                 1285                 1290             


Leu Asn  His Leu Lys Ser Lys  Glu Gly Lys Ala Glu  Leu Ala Phe 
    1295                 1300                 1305             


Ser Ala  Glu Gly Ile Glu Glu  Met Asn Arg Asn Leu  Leu Gln Leu 
    1310                 1315                 1320             


Asn Asp  Gly Lys Gly His Gln  Pro Ile Tyr Lys Val  Arg Val Tyr 
    1325                 1330                 1335             


Glu Pro  Arg Gly Asn Lys Phe  Lys Val Gly Val Leu  Gly Asn Lys 
    1340                 1345                 1350             


Gly Ala  Lys Trp Val Glu Ala  Ala Lys Gly Thr Asn  Leu Phe Phe 
    1355                 1360                 1365             


Ala Ile  Tyr Ile Thr Glu Asp  Gly Asn Arg Thr Tyr  Glu Thr Ile 
    1370                 1375                 1380             


Pro Leu  Asn Trp Val Ile Glu  Arg Glu Lys Gln Gly  Leu Val Pro 
    1385                 1390                 1395             


Val Pro  Asp Arg Asn Glu Lys  Gly Asp Lys Leu Leu  Phe Trp Leu 
    1400                 1405                 1410             


Ser Pro  Asn Asp Leu Val Tyr  Leu Pro Thr Glu Glu  Glu Arg Asp 
    1415                 1420                 1425             


Phe Gly  Arg Ile Asn Glu Pro  Ile Asp Arg Gly Arg  Ile Tyr Lys 
    1430                 1435                 1440             


Met Val  Ser Ser Ser Gly Asn  Gln Cys Phe Phe Ile  Pro Gln Ser 
    1445                 1450                 1455             


Ile Ser  Asn Ala Ile Ile Ser  Thr Lys Glu Leu Gly  Ser Asn Asn 
    1460                 1465                 1470             


Lys Ala  Glu Lys Ser Trp Asp  Gly Glu Met Ile Lys  Asn Ile Cys 
    1475                 1480                 1485             


Ile Pro  Val Lys Val Asp Arg  Leu Gly Arg Ile Ile  Glu Val Lys 
    1490                 1495                 1500             


Tyr Arg  Val Asn Glu 
    1505             


<210> 88
<211> 1504
<212> PRT
<213> Bacteroides vulgatus


<220>
<223> Bacteroides vulgatus CL09T03C04

<400> 88
Met Lys Asn Ile Val Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Val Asn Gly Ser Val Asn Asp Asp Gly Ser Glu Gln Leu Val 
            20                  25                  30          


Lys Ile Gln Ala Ser Gly Ser Arg Ile Ile Pro Met Asp Ala Ala Met 
        35                  40                  45              


Ile Gly Asp Phe Asn Lys Gly Asn Ser Ile Ser Gln Thr Ala Glu Arg 
    50                  55                  60                  


Thr Arg Leu Arg Gly Val Arg Arg Leu Ser Glu Arg Tyr Leu Leu Arg 
65                  70                  75                  80  


Arg Glu Arg Leu His Arg Ile Leu Asp Ile Leu Gly Phe Leu Pro Phe 
                85                  90                  95      


His Phe Ala Gln Asp Leu Asp Arg His Gly Lys Ile Val Lys Gly Lys 
            100                 105                 110         


Glu Pro Lys Leu Ala Trp Arg Lys Asn Glu Ala Gly Gln Phe Glu Phe 
        115                 120                 125             


Ile Phe Gln Asp Ser Phe Lys Glu Met Leu Glu Asp Phe Lys Leu Asn 
    130                 135                 140                 


His Pro Asn Leu Ile Thr Asp Asp Lys Lys Val Pro Tyr Asp Trp Thr 
145                 150                 155                 160 


Ile Tyr Tyr Leu Arg Lys Lys Gly Leu Thr Ser Lys Ile Ser Lys Glu 
                165                 170                 175     


Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr 
            180                 185                 190         


Gln Leu Arg Gly Glu Glu Glu Glu Glu Asn Lys Asn Lys Leu Val Glu 
        195                 200                 205             


Phe Tyr Ala Leu Lys Val Val Ala Val Glu Asp Ser Gly Glu Lys Lys 
    210                 215                 220                 


Gly Lys Asp Ile Trp Tyr Asn Val His Leu Glu Asn Gly Trp Val Tyr 
225                 230                 235                 240 


Arg Arg Thr Ser Asn Met Pro Leu Asp Trp Val Gly Lys Thr Lys Glu 
                245                 250                 255     


Phe Ile Val Thr Thr Asp Leu Glu Lys Asp Gly Thr Pro Lys Lys Asp 
            260                 265                 270         


Lys Glu Gly Asn Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp Asp 
        275                 280                 285             


Trp Ser Leu Leu Lys Lys Lys Thr Glu Ala Asp Ile Asp Gln Thr His 
    290                 295                 300                 


Lys Thr Val Gly Val Tyr Ile Tyr Asp Thr Leu Leu Gly Asn Pro Ser 
305                 310                 315                 320 


Gln Lys Ile Arg Gly Arg Leu Val Arg Thr Ile Glu Arg Lys Tyr Tyr 
                325                 330                 335     


Lys Glu Glu Leu Lys Gln Ile Leu Glu Lys Gln Lys Glu Phe His Leu 
            340                 345                 350         


Glu Leu Gln Asp Arg Ala Leu Tyr Ala Ala Cys Ile Glu Glu Leu Tyr 
        355                 360                 365             


Pro Ile Asn Glu Ala His Arg Asn Asn Val Gly Asn Arg Asp Phe Thr 
    370                 375                 380                 


Tyr Leu Phe Leu Glu Asp Ile Leu Phe Tyr Gln Arg Pro Leu Lys Ser 
385                 390                 395                 400 


Lys Lys Ser Leu Ile Asp Asn Cys Pro Tyr Glu Glu Asn Gln Gly Leu 
                405                 410                 415     


Asp Lys Glu Thr Gly Glu Ile Lys Ser Phe Pro Val Lys Cys Ile Ala 
            420                 425                 430         


Lys Ser His Pro Leu Phe Gln Glu Phe Arg Leu Trp Gln Phe Ile Val 
        435                 440                 445             


Asn Leu Arg Ile Tyr Arg Lys Asp Leu Ala Gln Asp Val Asp Val Thr 
    450                 455                 460                 


Asn Glu Leu Leu Lys Thr Glu Glu Asp Tyr Val Ala Leu Phe Asp Trp 
465                 470                 475                 480 


Leu Asn Gly Lys Lys Glu Ile Asp Gln Lys Ala Phe Leu Lys Tyr Pro 
                485                 490                 495     


Val Phe Gly Leu Lys Lys Glu Ile Glu Asn Tyr Arg Trp Asn Tyr Val 
            500                 505                 510         


Gln Asp Lys Pro Tyr Pro Cys Asn Glu Thr Arg Ser Leu Met Leu Ala 
        515                 520                 525             


Arg Leu Glu Lys Cys Asp Ile Ser Ile Glu Phe Leu Thr Lys Glu Asn 
    530                 535                 540                 


Glu Glu Ala Leu Trp His Ile Leu Tyr Ser Val Glu Asp Lys Asn Glu 
545                 550                 555                 560 


Ile Val Lys Ala Leu Gln Lys Phe Ala Asp Lys His Asp Leu Asn Ala 
                565                 570                 575     


Ser Phe Val Asp Val Phe Gln Lys Phe Pro Pro Phe Lys Lys Glu Tyr 
            580                 585                 590         


Gly Ser Tyr Ser Ala Lys Ala Ile Lys Lys Leu Leu Pro Leu Met Arg 
        595                 600                 605             


Met Gly Lys Tyr Trp Ser Glu Asn Ser Ile Asp Lys Gly Thr Arg Glu 
    610                 615                 620                 


Arg Ile Asp Lys Ile Ile Thr Gly Glu Tyr Asp Glu Lys Ile Glu Asn 
625                 630                 635                 640 


Arg Val Arg Glu Lys Ala Ile His Leu Ala Asp Val Ser Asp Phe Lys 
                645                 650                 655     


Gly Leu Pro Leu Trp Leu Val Cys Tyr Ile Val Tyr Gly Arg His Ser 
            660                 665                 670         


Glu Ala Lys Glu Ile Thr Gln Trp Lys Ser Pro Ala Asp Ile Asp Ser 
        675                 680                 685             


Tyr Leu Arg Ser Phe Lys Gln His Ser Leu Arg Asn Pro Ile Val Glu 
    690                 695                 700                 


Gln Ile Ile Ile Glu Thr Leu Arg Val Val Arg Asp Ile Trp Lys Gln 
705                 710                 715                 720 


Val Gly Asn Ile Asp Glu Ile His Val Glu Leu Gly Arg Glu Met Lys 
                725                 730                 735     


Asn Pro Ala Asp Lys Arg Lys Lys Met Thr Gln Gln Met Ser Glu Asn 
            740                 745                 750         


Glu Asn Thr Asn Leu Arg Ile Lys Tyr Leu Leu Thr Glu Phe Leu Asn 
        755                 760                 765             


Pro Glu Tyr Glu Val Glu Asn Val Arg Pro Tyr Ser Pro Ser Gln Gln 
    770                 775                 780                 


Asp Ile Leu Arg Ile Tyr Glu Glu Gly Val Leu Asn Ser Val Ser Asp 
785                 790                 795                 800 


Leu Pro Glu Glu Ile Ser Asp Ile Leu Lys Lys Phe Thr Glu Thr Asp 
                805                 810                 815     


Leu Lys Lys Arg Pro Ser Arg Ser Glu Ile Leu Arg Tyr Lys Leu Trp 
            820                 825                 830         


Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Glu Val Ile Pro Leu 
        835                 840                 845             


Gly Lys Leu Phe Thr Pro Ala Tyr Glu Ile Glu His Val Ile Pro Gln 
    850                 855                 860                 


Ser Cys Tyr Phe Asp Asp Ser Phe Ser Asn Lys Val Ile Cys Glu Ala 
865                 870                 875                 880 


Glu Val Asn Lys Leu Lys Ser Asn Leu Leu Gly His Glu Phe Ile Val 
                885                 890                 895     


Lys His His Gly Glu Ile Val Glu Leu Pro Phe Gly Lys Lys Val Arg 
            900                 905                 910         


Ile Phe Thr Val Asp Glu Tyr Glu Gln Phe Val Lys Asp Asn Tyr Ser 
        915                 920                 925             


Arg Thr Arg Ser Lys Met Lys Lys Leu Leu Met Asp Asp Ile Pro Glu 
    930                 935                 940                 


Glu Phe Val Thr Arg Gln Leu Asn Asp Ser Arg Tyr Ile Ser Lys Val 
945                 950                 955                 960 


Val Lys Ser Leu Leu Ser Asn Ile Val Arg Glu Lys Gly Glu Glu Glu 
                965                 970                 975     


Ala Ile Ser Lys Asn Val Ile Pro Cys Thr Gly Gly Val Thr Asp Arg 
            980                 985                 990         


Leu Lys Lys Asp Trp Gly Ile Asn  Glu Val Trp Asn Lys  Ile Ile Leu 
        995                 1000                 1005             


Pro Arg  Phe Gln Arg Leu Asn  Glu Leu Thr Gly Thr  Asn Lys Phe 
    1010                 1015                 1020             


Thr Thr  Lys Asn Val Gly Ile  Gln Glu Ile Pro Thr  Met Pro Leu 
    1025                 1030                 1035             


Glu Leu  Gln Lys Gly Phe Asn  Lys Lys Arg Ile Asp  His Arg His 
    1040                 1045                 1050             


His Ala  Met Asp Ala Ile Ile  Ile Ala Cys Ala Asn  Arg Asn Ile 
    1055                 1060                 1065             


Ile Asn  Tyr Leu Asn Asn Glu  Ser Ala Thr Ala Lys  Ala Glu Leu 
    1070                 1075                 1080             


Ser Arg  Tyr Asp Leu Gln Lys  Met Leu Cys Asp Lys  Ala Lys Thr 
    1085                 1090                 1095             


Asp Asn  Asn Gly Asn Tyr Lys  Trp Val Ile Arg Lys  Pro Trp Ala 
    1100                 1105                 1110             


Ser Phe  Thr Gln Asp Thr Tyr  Leu Ala Leu Glu Asn  Ile Ile Val 
    1115                 1120                 1125             


Ser Phe  Lys Gln Asn Leu Arg  Val Ile Asn Lys Ala  Thr Asn Arg 
    1130                 1135                 1140             


Phe Leu  His Tyr Asn Glu Glu  Gly Lys Lys Ile Phe  Val Lys Gln 
    1145                 1150                 1155             


Gly Lys  Gly Asp Asn Trp Ala  Ile Arg Lys Ser Met  His Lys Asp 
    1160                 1165                 1170             


Thr Val  Phe Gly Glu Val Asn  Leu Arg Arg Ile Lys  Thr Val Ala 
    1175                 1180                 1185             


Leu Asn  Glu Ala Met Lys Asn  Pro Gln Ser Ile Val  Val Lys Asp 
    1190                 1195                 1200             


Phe Lys  Arg Lys Leu Leu Glu  Leu Trp Asn Leu Gly  Phe Asp Ala 
    1205                 1210                 1215             


Lys Arg  Ile Lys Lys Tyr Phe  Glu Asp Asn Arg Glu  Thr Trp Ser 
    1220                 1225                 1230             


Asp Ile  Asn Leu Ser Lys Ile  Glu Val Tyr Tyr Phe  Ser Lys Asp 
    1235                 1240                 1245             


Thr Lys  Asp Arg Phe Phe Ala  Thr Arg Lys Pro Leu  Asp Thr Ser 
    1250                 1255                 1260             


Phe Asp  Arg Lys Lys Ile Glu  Asn Asn Ile Thr Asp  Thr Gly Ile 
    1265                 1270                 1275             


Gln Lys  Ile Leu Leu Arg His  Leu Glu Leu Lys Asp  Asn Asn Pro 
    1280                 1285                 1290             


Asp Ile  Ala Phe Ser Pro Asp  Gly Ile Asp Glu Met  Asn Arg Asn 
    1295                 1300                 1305             


Ile Ile  Gln Leu Asn Asn Gly  Lys Tyr His Gln Pro  Ile Ile Lys 
    1310                 1315                 1320             


Ile Arg  Trp Tyr Glu Gln Ala  Asp Lys Phe Ala Val  Gly Gln Thr 
    1325                 1330                 1335             


Gly Asn  Lys Phe Ser Lys Phe  Val Glu Ala Ala Lys  Gly Thr Asn 
    1340                 1345                 1350             


Leu Phe  Phe Ala Val Tyr Glu  Ser Asn Ile Leu Asp  Lys Lys Thr 
    1355                 1360                 1365             


Asn Thr  Ile Ile Lys Lys Arg  Asn Tyr Ala Thr Ile  Pro Leu Asn 
    1370                 1375                 1380             


Val Ala  Ile Glu Arg Gln Lys  Gln Gly Leu Pro Val  Ala Pro Glu 
    1385                 1390                 1395             


Asp Glu  Asn Gly Asn Asp Pro  Ile Phe Val Leu Ser  Pro Asn Asp 
    1400                 1405                 1410             


Leu Val  Tyr Leu Pro Thr Asp  Asp Glu Leu Ala Asn  Gly Ile Ile 
    1415                 1420                 1425             


Ala Gln  Pro Leu Asp Arg Gly  Arg Ile Tyr Lys Met  Val Ser Cys 
    1430                 1435                 1440             


Thr Gly  Asn Glu Gly His Phe  Ile Pro Ala Arg Ile  Ala Asn Pro 
    1445                 1450                 1455             


Ile Leu  Gln Thr Ile Glu Leu  Gly Ser Asn Asn Lys  Ala Gln Lys 
    1460                 1465                 1470             


Ala Trp  Thr Asp Glu Met Ile  Lys Glu Ile Cys Met  Pro Ile Lys 
    1475                 1480                 1485             


Val Asp  Arg Leu Gly Asn Val  Leu Glu Ser Ser Ser  Ser Tyr Lys 
    1490                 1495                 1500             


Lys 
    


<210> 89
<211> 1434
<212> PRT
<213> Unknown


<220>
<223> Description of Unknown: Bacteroidetes oral taxon 274 
      str. F0058 polypeptide

<400> 89
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Tyr Val Lys Gln Ala Gln Asn Asp Ser Glu Lys Ser Glu Ile Ala 
            20                  25                  30          


Glu Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Lys Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Pro Ile Ser Thr Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Ala Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Gln Glu 
65                  70                  75                  80  


Leu Ile Glu Leu Leu Lys Asp Tyr Gln Val Ile Ser Asp Lys Thr Ile 
                85                  90                  95      


Leu Ala Glu Asp Gly Lys Glu Thr Thr Phe Glu Thr Leu Arg Leu Arg 
            100                 105                 110         


Val Lys Ser Ala Lys Glu Gln Val Ser Leu Glu Glu Leu Ala Arg Ile 
        115                 120                 125             


Leu Leu Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Asn Glu Asp Glu Gly Gln Leu Ile Asp Gly Met Glu Ile Ala Arg 
145                 150                 155                 160 


Arg Leu Tyr Asp Glu Asn Leu Thr Thr Gly Gln Leu Ser Leu Gln Leu 
                165                 170                 175     


Leu Lys Glu Gly Lys Lys Ser Leu Pro Asp Tyr Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln His Glu Leu Asp Lys Val Trp Asn Phe Gln Lys Gln Phe His Pro 
        195                 200                 205             


Asp Ile Leu Thr Asp Glu Phe Tyr Thr Ser Ile Gln Gly Lys Gly Gln 
    210                 215                 220                 


Lys Ala Thr Arg Glu Ser Phe Ser Ser Lys Tyr Gly Ile Asp Thr Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Ser Arg Glu Glu Lys Lys Leu Gln Ala Tyr Gln Trp 
                245                 250                 255     


Arg Ala Asp Ala Thr His Lys Glu Leu Thr Lys Glu Glu Leu Ala Phe 
            260                 265                 270         


Val Ile Thr Glu Ile Asn Asn Asn Ile Asn Asn Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Ile Phe Ala Asn Glu Thr 
    290                 295                 300                 


Val Gly Glu Tyr Leu Trp Lys Gln Ile Gln Asn Asp Pro His Thr Ser 
305                 310                 315                 320 


Leu Lys Asn Gln Val Phe Tyr Arg Gln Asp Tyr Phe Asp Glu Phe Glu 
                325                 330                 335     


Arg Ile Trp Glu Thr Gln Ser Gly Phe Tyr Pro Gln Ile Leu Thr Glu 
            340                 345                 350         


Ser Leu Lys Asn Glu Leu Arg Asp Ile Leu Ile Phe Tyr Gln Arg Lys 
        355                 360                 365             


Leu Lys Ser Gln Lys Ala Leu Val Ser Ile Cys Glu Phe Glu Ser Lys 
    370                 375                 380                 


Glu Ile Pro Leu Lys Asp Lys Gln Gly Asn Pro Ile Ser Lys Asn Gly 
385                 390                 395                 400 


Ile Pro Val Thr Lys Leu Val Gly Pro Lys Val Ala Pro Lys Ser Ser 
                405                 410                 415     


Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln Asn Leu Asn Asn Val Leu 
            420                 425                 430         


Val Arg Pro Lys Gly Ser Arg Lys Arg Lys Val Thr Thr Asn Gln Gln 
        435                 440                 445             


Ser Thr Leu Leu Glu Gly Gln Glu Pro Val Phe Glu Leu Asn Leu Glu 
    450                 455                 460                 


Gln Lys Glu Leu Leu Phe Glu Glu Leu Asn Leu Lys Gly Asn Leu Lys 
465                 470                 475                 480 


Thr Asp Tyr Cys Leu Glu Leu Ile Gly Tyr Ser Ala Lys Glu Trp Glu 
                485                 490                 495     


Met Asn Tyr Pro Thr Leu Glu Gly Asn Lys Thr Asn Lys Ala Leu Tyr 
            500                 505                 510         


Glu Ala Tyr Leu Lys Ile Ile Asp Ser Glu Gly Tyr Asp Ala Lys Lys 
        515                 520                 525             


Leu Leu Lys Val Lys Thr Asp Lys Asp Asp Ile Asn Leu Asp Asp Ile 
    530                 535                 540                 


Lys Val Ser Ala Ser Glu Ile Lys Thr Met Ile Ser Asp Ile Phe Asn 
545                 550                 555                 560 


Glu Leu Gly Ile Asn Thr Lys Ile Leu Asp Phe Asp Ala Glu Leu Glu 
                565                 570                 575     


Arg Lys Gln Phe Glu Ala Gln Ala Ser Tyr Arg Leu Trp His Leu Leu 
            580                 585                 590         


Tyr Ser Tyr Glu Gly Asp Asp Ser Lys Ser Gly Asn Glu Leu Leu Tyr 
        595                 600                 605             


Arg Leu Leu Glu Asp Lys Phe Gly Phe Lys Arg Glu His Ser Lys Thr 
    610                 615                 620                 


Leu Ala Asn Val Ser Leu Leu Ser Asp Tyr Gly Asn Leu Ser Thr Lys 
625                 630                 635                 640 


Ala Ile Arg Thr Ile Tyr Pro Tyr Ile Lys Glu Asn Lys Phe Ser Thr 
                645                 650                 655     


Ala Cys Glu Leu Ala Gly Tyr Arg His Ser Lys Leu Ser Ile Ser Lys 
            660                 665                 670         


Glu Glu Asn Glu Asn Arg Thr Leu Lys Asp Thr Leu Asp Val Leu Lys 
        675                 680                 685             


Lys Asn Ser Leu Arg Gln Pro Val Val Glu Lys Ile Leu Asn Gln Met 
    690                 695                 700                 


Ile Asn Leu Ile Asn Glu Leu Ile Glu Lys His Ser Glu Lys Asp Glu 
705                 710                 715                 720 


Lys Gly Asn Ile Val Lys Tyr Phe Lys Phe Asp Glu Ile His Ile Glu 
                725                 730                 735     


Leu Ala Arg Glu Leu Lys Lys Asn Ala Glu Glu Arg Arg Glu Leu Asp 
            740                 745                 750         


Ser Lys Val Arg Glu Gly Lys Asp Arg Asn Glu Lys Ile Ile Thr Ile 
        755                 760                 765             


Leu Lys Ser Glu Phe Gly Leu Pro Tyr Pro Thr Lys Asn Asp Ile Thr 
    770                 775                 780                 


Arg Tyr Arg Leu Tyr Glu Glu Leu Lys Asp Asn Gly Tyr Lys Asp Leu 
785                 790                 795                 800 


Tyr Thr Asn Thr Tyr Ile Pro Arg Glu Lys Leu Phe Ser Lys Glu Ile 
                805                 810                 815     


Asp Ile Glu His Ile Ile Pro Lys Ser Arg Leu Phe Asn Asp Ser Phe 
            820                 825                 830         


Ser Asn Lys Thr Ile Cys Tyr Arg Gln Asp Asn Leu Asn Lys Gly Glu 
        835                 840                 845             


Arg Thr Ala Tyr Asp Tyr Ile Glu Gly Leu Gly Lys Thr Gln Leu Asp 
    850                 855                 860                 


Glu Tyr Leu Asn Arg Val Glu Asn Leu Tyr Thr Asn Lys Phe Ile Thr 
865                 870                 875                 880 


Lys Ala Lys Tyr Arg Asn Leu Leu Lys Lys Glu Ser Glu Ile Gly Asp 
                885                 890                 895     


Gly Phe Ile Glu Arg Asp Leu Arg Glu Thr Gln Tyr Ile Ala Lys Lys 
            900                 905                 910         


Ala Lys Glu Met Leu Leu Gln Ile Thr Arg His Val Val Ser Thr Thr 
        915                 920                 925             


Gly Ser Ile Thr Asp Arg Leu Arg Asp Asp Trp Glu Leu Val Asn Val 
    930                 935                 940                 


Met Arg Glu Leu Asn Leu Pro Lys Tyr Lys Val Leu Gly Leu Thr Glu 
945                 950                 955                 960 


Ile Gln Glu Arg Lys Asn Gly Gln Thr Val Glu Val Ile Thr Asp Trp 
                965                 970                 975     


Thr Lys Arg Asn Asp His Arg His His Ala Met Asp Ala Leu Thr Val 
            980                 985                 990         


Ala Phe Thr Lys His Ser His Ile  Gln Tyr Leu Asn Phe  Leu Asn Ala 
        995                 1000                 1005             


Arg Lys  Asp Glu Lys His Lys  Glu Tyr Ser Asn Ile  Met Gly Ile 
    1010                 1015                 1020             


Gln Gln  Leu Glu Thr Glu Lys  Thr Thr Asp Lys Asp  Gly Lys Asp 
    1025                 1030                 1035             


Arg Arg  Val Phe Lys Thr Pro  Ile Pro Asn Phe Arg  Gln Val Ala 
    1040                 1045                 1050             


Lys Glu  His Leu Glu Ser Ile  Leu Ile Ser His Lys  Thr Lys Asn 
    1055                 1060                 1065             


Lys Val  Val Thr Arg Ala Thr  Asn Lys Ile Ala Gly  Ser Lys Lys 
    1070                 1075                 1080             


Gln Gln  Glu Thr Leu Ser Pro  Arg Gly Gln Leu His  Lys Glu Thr 
    1085                 1090                 1095             


Val Tyr  Gly Lys Tyr Arg Arg  Tyr Val Gln Lys Glu  Glu Lys Ile 
    1100                 1105                 1110             


Gly Ser  Lys Phe Asp Leu Gln  Thr Ile Glu Arg Val  Ala Asn Pro 
    1115                 1120                 1125             


Leu Tyr  Lys Arg Leu Leu Thr  Lys Arg Leu Glu Glu  Asn Gly Gly 
    1130                 1135                 1140             


Asp Pro  Lys Lys Ala Phe Thr  Gly Lys Asn Ala Leu  Ala Lys Ser 
    1145                 1150                 1155             


Pro Ile  Tyr Leu Asp Glu Thr  Gln Thr Gln Gln Leu  Pro Glu Lys 
    1160                 1165                 1170             


Val Lys  Leu Val Trp Leu Glu  Thr Asp Phe Ser Ile  Arg Lys Asp 
    1175                 1180                 1185             


Ile Thr  Pro Asp Asn Phe Lys  Asp Glu Lys Ser Ile  Asp Lys Val 
    1190                 1195                 1200             


Leu Asp  Glu Gly Ile Lys Arg  Ile Leu Lys Asp Arg  Leu Lys Ser 
    1205                 1210                 1215             


Phe Asp  Gly Asp Ala Lys Arg  Ala Phe Thr Asp Leu  Glu Gln Asn 
    1220                 1225                 1230             


Pro Ile  Trp Leu Asn Lys Glu  Lys Gly Ile Ala Ile  Lys Arg Val 
    1235                 1240                 1245             


Thr Ile  Ser Gly Val Ser Asn  Ala Glu Pro Leu His  Thr Lys Lys 
    1250                 1255                 1260             


Asp His  Leu Gly Asn Glu Ile  Phe Asp Asp Thr Gly  Lys Pro Ile 
    1265                 1270                 1275             


Pro Val  Asp Tyr Val Ser Thr  Gly Asn Asn His His  Ile Ala Ile 
    1280                 1285                 1290             


Tyr Arg  Asp Glu Asn Gly Asn  Leu Gln Glu Lys Ala  Val Ser Phe 
    1295                 1300                 1305             


Phe Glu  Ala Val Thr Arg Ala  Asn Gln Gly Leu Pro  Thr Val Asp 
    1310                 1315                 1320             


Lys Thr  Tyr Asn Gln His Leu  Gly Trp Gln Phe Leu  Phe Thr Met 
    1325                 1330                 1335             


Lys Gln  Asn Glu Met Phe Val  Phe Pro Asn Lys Glu  Thr Gly Phe 
    1340                 1345                 1350             


Asp Pro  Gln Glu Ile Asp Leu  Leu Asp Pro Lys Asn  Lys Lys Leu 
    1355                 1360                 1365             


Ile Ser  Pro Asn Leu Phe Arg  Val Gln Lys Ile Ser  Thr Lys Asn 
    1370                 1375                 1380             


Tyr Phe  Phe Arg His His Leu  Glu Thr Ser Val Glu  Thr His Asn 
    1385                 1390                 1395             


Ala Leu  Asn Gly Val Thr Tyr  Lys Ser Gln Leu Gly  Leu Asn Gly 
    1400                 1405                 1410             


Ile Thr  Asp Ile Ile Lys Val  Arg Ile Asn His Leu  Gly Asp Ile 
    1415                 1420                 1425             


Val His  Ile Gly Glu Tyr 
    1430                 


<210> 90
<211> 1153
<212> PRT
<213> Barnesiella intestinihominis


<220>
<223> Barnesiella intestinihominis YIT 11860

<400> 90
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Leu Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ser Val Ile Arg Glu Asn Ser Glu Glu Gln Glu Leu Val Ala Met Gly 
            20                  25                  30          


Ser Arg Val Val Ser Leu Thr Ala Ala Glu Leu Ser Ser Phe Thr Gln 
        35                  40                  45              


Gly Asn Gly Val Ser Ile Asn Ser Gln Arg Thr Gln Lys Arg Thr Gln 
    50                  55                  60                  


Arg Lys Gly Tyr Asp Arg Tyr Gln Leu Arg Arg Thr Leu Leu Arg Asn 
65                  70                  75                  80  


Lys Leu Asp Thr Leu Gly Met Leu Pro Asp Asp Ser Leu Ser Tyr Leu 
                85                  90                  95      


Pro Lys Leu Gln Leu Trp Gly Leu Arg Ala Lys Ala Val Thr Gln Arg 
            100                 105                 110         


Ile Glu Leu Asn Glu Leu Gly Arg Val Leu Leu His Leu Asn Gln Lys 
        115                 120                 125             


Arg Gly Tyr Lys Ser Ile Lys Ser Asp Phe Ser Gly Asp Lys Lys Ile 
    130                 135                 140                 


Thr Asp Tyr Val Lys Thr Val Lys Thr Arg Tyr Asp Glu Leu Lys Glu 
145                 150                 155                 160 


Met Arg Leu Thr Ile Gly Glu Leu Phe Phe Arg Arg Leu Thr Glu Asn 
                165                 170                 175     


Ala Phe Phe Arg Cys Lys Glu Gln Val Tyr Pro Arg Gln Ala Tyr Val 
            180                 185                 190         


Glu Glu Phe Asp Cys Ile Met Asn Cys Gln Arg Lys Phe Tyr Pro Asp 
        195                 200                 205             


Ile Leu Thr Asp Glu Thr Ile Arg Cys Ile Arg Asp Glu Ile Ile Tyr 
    210                 215                 220                 


Tyr Gln Arg Pro Leu Lys Ser Cys Lys Tyr Leu Val Ser Arg Cys Glu 
225                 230                 235                 240 


Phe Glu Lys Arg Phe Tyr Leu Asn Ala Ala Gly Lys Lys Thr Glu Ala 
                245                 250                 255     


Gly Pro Lys Val Ser Pro Arg Thr Ser Pro Leu Phe Gln Val Cys Arg 
            260                 265                 270         


Leu Trp Glu Ser Ile Asn Asn Ile Val Val Lys Asp Arg Arg Asn Glu 
        275                 280                 285             


Ile Val Phe Ile Ser Ala Glu Gln Arg Ala Ala Leu Phe Asp Phe Leu 
    290                 295                 300                 


Asn Thr His Glu Lys Leu Lys Gly Ser Asp Leu Leu Lys Leu Leu Gly 
305                 310                 315                 320 


Leu Ser Lys Thr Tyr Gly Tyr Arg Leu Gly Glu Gln Phe Lys Thr Gly 
                325                 330                 335     


Ile Gln Gly Asn Lys Thr Arg Val Glu Ile Glu Arg Ala Leu Gly Asn 
            340                 345                 350         


Tyr Pro Asp Lys Lys Arg Leu Leu Gln Phe Asn Leu Gln Glu Glu Ser 
        355                 360                 365             


Ser Ser Met Val Asn Thr Glu Thr Gly Glu Ile Ile Pro Met Ile Ser 
    370                 375                 380                 


Leu Ser Phe Glu Gln Glu Pro Leu Tyr Arg Leu Trp His Val Leu Tyr 
385                 390                 395                 400 


Ser Ile Asp Asp Arg Glu Gln Leu Gln Ser Val Leu Arg Gln Lys Phe 
                405                 410                 415     


Gly Ile Asp Asp Asp Glu Val Leu Glu Arg Leu Ser Ala Ile Asp Leu 
            420                 425                 430         


Val Lys Ala Gly Phe Gly Asn Lys Ser Ser Lys Ala Ile Arg Arg Ile 
        435                 440                 445             


Leu Pro Phe Leu Gln Leu Gly Met Asn Tyr Ala Glu Ala Cys Glu Ala 
    450                 455                 460                 


Ala Gly Tyr Asn His Ser Asn Asn Tyr Thr Lys Ala Glu Asn Glu Ala 
465                 470                 475                 480 


Arg Ala Leu Leu Asp Arg Leu Pro Ala Ile Lys Lys Asn Glu Leu Arg 
                485                 490                 495     


Gln Pro Val Val Glu Lys Ile Leu Asn Gln Met Val Asn Val Val Asn 
            500                 505                 510         


Ala Leu Met Glu Lys Tyr Gly Arg Phe Asp Glu Ile Arg Val Glu Leu 
        515                 520                 525             


Ala Arg Glu Leu Lys Gln Ser Lys Glu Glu Arg Ser Asn Thr Tyr Lys 
    530                 535                 540                 


Ser Ile Asn Lys Asn Gln Arg Glu Asn Glu Gln Ile Ala Lys Arg Ile 
545                 550                 555                 560 


Val Glu Tyr Gly Val Pro Thr Arg Ser Arg Ile Gln Lys Tyr Lys Met 
                565                 570                 575     


Trp Glu Glu Ser Lys His Cys Cys Ile Tyr Cys Gly Gln Pro Val Asp 
            580                 585                 590         


Val Gly Asp Phe Leu Arg Gly Phe Asp Val Glu Val Glu His Ile Ile 
        595                 600                 605             


Pro Lys Ser Leu Tyr Phe Asp Asp Ser Phe Ala Asn Lys Val Cys Ser 
    610                 615                 620                 


Cys Arg Ser Cys Asn Lys Glu Lys Asn Asn Arg Thr Ala Tyr Asp Tyr 
625                 630                 635                 640 


Met Lys Ser Lys Gly Glu Lys Ala Leu Ser Asp Tyr Val Glu Arg Val 
                645                 650                 655     


Asn Thr Met Tyr Thr Asn Asn Gln Ile Ser Lys Thr Lys Trp Gln Asn 
            660                 665                 670         


Leu Leu Thr Pro Val Asp Lys Ile Ser Ile Asp Phe Ile Asp Arg Gln 
        675                 680                 685             


Leu Arg Glu Ser Gln Tyr Ile Ala Arg Lys Ala Lys Glu Ile Leu Thr 
    690                 695                 700                 


Ser Ile Cys Tyr Asn Val Thr Ala Thr Ser Gly Ser Val Thr Ser Phe 
705                 710                 715                 720 


Leu Arg His Val Trp Gly Trp Asp Thr Val Leu His Asp Leu Asn Phe 
                725                 730                 735     


Asp Arg Tyr Lys Lys Val Gly Leu Thr Glu Val Ile Glu Val Asn His 
            740                 745                 750         


Arg Gly Ser Val Ile Arg Arg Glu Gln Ile Lys Asp Trp Ser Lys Arg 
        755                 760                 765             


Phe Asp His Arg His His Ala Ile Asp Ala Leu Thr Ile Ala Cys Thr 
    770                 775                 780                 


Lys Gln Ala Tyr Ile Gln Arg Leu Asn Asn Leu Arg Ala Glu Glu Gly 
785                 790                 795                 800 


Pro Asp Phe Asn Lys Met Ser Leu Glu Arg Tyr Ile Gln Ser Gln Pro 
                805                 810                 815     


His Phe Ser Val Ala Gln Val Arg Glu Ala Val Asp Arg Ile Leu Val 
            820                 825                 830         


Ser Phe Arg Ala Gly Lys Arg Ala Val Thr Pro Gly Lys Arg Tyr Ile 
        835                 840                 845             


Arg Lys Asn Arg Lys Arg Ile Ser Val Gln Ser Val Leu Ile Pro Arg 
    850                 855                 860                 


Gly Ala Leu Ser Glu Glu Ser Val Tyr Gly Val Ile His Val Trp Glu 
865                 870                 875                 880 


Lys Asp Glu Gln Gly His Val Ile Gln Lys Gln Arg Ala Val Met Lys 
                885                 890                 895     


Tyr Pro Ile Thr Ser Ile Asn Arg Glu Met Leu Asp Lys Glu Lys Val 
            900                 905                 910         


Val Asp Lys Arg Ile His Arg Ile Leu Ser Gly Arg Leu Ala Gln Tyr 
        915                 920                 925             


Asn Asp Asn Pro Lys Glu Ala Phe Ala Lys Pro Val Tyr Ile Asp Lys 
    930                 935                 940                 


Glu Cys Arg Ile Pro Ile Arg Thr Val Arg Cys Phe Ala Lys Pro Ala 
945                 950                 955                 960 


Ile Asn Thr Leu Val Pro Leu Lys Lys Asp Asp Lys Gly Asn Pro Val 
                965                 970                 975     


Ala Trp Val Asn Pro Gly Asn Asn His His Val Ala Ile Tyr Arg Asp 
            980                 985                 990         


Glu Asp Gly Lys Tyr Lys Glu Arg  Thr Val Thr Phe Trp  Glu Ala Val 
        995                 1000                 1005             


Asp Arg  Cys Arg Val Gly Ile  Pro Ala Ile Val Thr  Gln Pro Asp 
    1010                 1015                 1020             


Thr Ile  Trp Asp Asn Ile Leu  Gln Arg Asn Asp Ile  Ser Glu Asn 
    1025                 1030                 1035             


Val Leu  Glu Ser Leu Pro Asp  Val Lys Trp Gln Phe  Val Leu Ser 
    1040                 1045                 1050             


Leu Gln  Gln Asn Glu Met Phe  Ile Leu Gly Met Asn  Glu Glu Asp 
    1055                 1060                 1065             


Tyr Arg  Tyr Ala Met Asp Gln  Gln Asp Tyr Ala Leu  Leu Asn Lys 
    1070                 1075                 1080             


Tyr Leu  Tyr Arg Val Gln Lys  Leu Ser Lys Ser Asp  Tyr Ser Phe 
    1085                 1090                 1095             


Arg Tyr  His Thr Glu Thr Ser  Val Glu Asp Lys Tyr  Asp Gly Lys 
    1100                 1105                 1110             


Pro Asn  Leu Lys Leu Ser Met  Gln Met Gly Lys Leu  Lys Arg Val 
    1115                 1120                 1125             


Ser Ile  Lys Ser Leu Leu Gly  Leu Asn Pro His Lys  Val His Ile 
    1130                 1135                 1140             


Ser Val  Leu Gly Glu Ile Lys  Glu Ile Ser 
    1145                 1150             


<210> 91
<211> 1352
<212> PRT
<213> Belliella baltica

<400> 91
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ile Lys Glu Pro Glu Lys Asp Val Val Gly Ser Glu Ile Val 
            20                  25                  30          


Asp Met Gly Val Arg Ile Val Pro Leu Ser Ser Asp Glu Glu Asn Asp 
        35                  40                  45              


Phe Ala Lys Gly Asn Thr Ile Ser Ile Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Ala Arg Arg Asn Leu Gln Arg Phe Lys Gln Arg Arg Asn Ala 
65                  70                  75                  80  


Leu Leu Glu Ile Phe Lys Glu Lys Lys Leu Ile Ser Thr Asn Phe Lys 
                85                  90                  95      


Tyr Ala Glu Asp Gly Pro Ser Ser Thr Phe Ser Thr Leu Asn Leu Arg 
            100                 105                 110         


Ala Lys Ala Ala Lys Glu Lys Ile Glu Leu Gln Asp Leu Val Lys Val 
        115                 120                 125             


Leu Leu Gln Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Ser Glu Glu Asp Asp Gly Ser Ala Ile Asp Ser Met Gly Ile Ala 
145                 150                 155                 160 


Lys Glu Leu Tyr Glu Asn Asp Leu Thr Pro Gly Gln Trp Val Tyr Glu 
                165                 170                 175     


Ala Leu Gln Lys Gly Arg Lys Asn Val Pro Asp Phe Tyr Arg Ser Asp 
            180                 185                 190         


Leu Gln Glu Glu Phe Lys Lys Ile Val Asn Tyr Gln Ser Glu Phe Phe 
        195                 200                 205             


Pro Asp Ile Phe Asn Ala Ser Phe Val Glu Asp Trp Met Gly Lys Ala 
    210                 215                 220                 


Ser Thr Pro Thr Lys Gln Tyr Phe Asn Lys Lys Gly Val Gln Leu Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Lys Arg Glu Glu Arg Arg Leu Gln Glu Tyr Lys Trp 
                245                 250                 255     


Arg Ala Glu Ala Val Asn Phe Lys Ile Asp Leu Ser Glu Ile Ala Leu 
            260                 265                 270         


Ile Leu Ser Gln Ile Asn Ser Gln Ile Ser Asn Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Lys Asn Leu Thr 
    290                 295                 300                 


Val Gly Gln Tyr Leu Tyr Gln Gln Ile Lys Lys Asn Pro His Thr Arg 
305                 310                 315                 320 


Leu Lys Gly Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Arg Ile Trp Ser Val Gln Ser Ser Phe Tyr Pro Gln Leu Asn Asp Ala 
            340                 345                 350         


Leu Lys Arg Glu Val Arg Asp Ile Thr Ile Phe Phe Gln Arg Arg Leu 
        355                 360                 365             


Lys Ser Gln Lys His Leu Ile Ser Asn Cys Glu Phe Glu Asp His His 
    370                 375                 380                 


Lys Val Val Pro Lys Ser His Pro Val Phe Gln Glu Phe Arg Ile Trp 
385                 390                 395                 400 


Gln Asn Leu Asn Asn Leu Leu Leu Ile Lys Lys Asp Asn Leu Asn Glu 
                405                 410                 415     


Lys Phe Asp Leu Glu Leu Glu Ser Lys Ile Ala Leu Ala Asn Glu Leu 
            420                 425                 430         


Ala Phe Lys Arg Glu Leu Asn Val Lys Asp Ala Leu Lys Ile Leu Gly 
        435                 440                 445             


Leu Lys Pro Asn Glu Trp Glu Phe Asn Phe Thr Lys Ile Glu Gly Asn 
    450                 455                 460                 


Arg Thr Asn Gln Ala Phe Phe Asp Ala Phe Ala Lys Ile Ile Glu Leu 
465                 470                 475                 480 


Glu Asp Gly Glu Pro Ile Asp Leu Gly Asp Leu Lys Ala Asp Asp Ile 
                485                 490                 495     


Leu Asp Gln Phe Ser Glu Ala Phe Leu Arg Ile Gly Ile Asp Thr Glu 
            500                 505                 510         


Leu Leu Gln Val Asn Ser Asp Ile Glu Gly Ala Glu Tyr Glu Lys Gln 
        515                 520                 525             


Ser Tyr Ile Gln Phe Trp His Leu Leu Tyr Ser Ser Glu Asp Asp Gln 
    530                 535                 540                 


Lys Leu Lys Leu Asn Leu Ile Arg Lys Phe Gly Phe Lys Pro Glu His 
545                 550                 555                 560 


Ala Lys Ile Leu Ala Ser Ile Ser Leu Gln Asp Asp His Ala Ser Leu 
                565                 570                 575     


Ser Ser Arg Ala Ile Lys Lys Ile Leu Pro His Leu Gln Ser Gly Leu 
            580                 585                 590         


Ile Tyr Asp Lys Ala Cys Thr Tyr Ala Gly Tyr Asn His Ser Ser Ser 
        595                 600                 605             


Phe Thr Lys Asp Glu Asn Glu Lys Arg Glu Leu Arg Ala Glu Leu Glu 
    610                 615                 620                 


Leu Leu Lys Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Leu 
625                 630                 635                 640 


Asn Gln Met Ile Asn Val Val Asn Ala Ile Leu Lys Asp Pro Glu Leu 
                645                 650                 655     


Gly Arg Pro Asp Glu Ile Arg Val Glu Met Ala Arg Glu Leu Lys Ala 
            660                 665                 670         


Asn Ala Glu Gln Arg Lys Asn Met Thr Ser Asn Ile Ala Ser Ala Thr 
        675                 680                 685             


Arg Asp His Asp Lys Tyr Arg Glu Ile Leu Lys Ser Glu Phe Gly Leu 
    690                 695                 700                 


Lys Arg Val Thr Lys Asn Asp Leu Leu Arg Tyr Lys Leu Trp Leu Glu 
705                 710                 715                 720 


Thr Asp Gly Ile Ser Leu Tyr Thr Gly Lys Pro Ile Glu Ala Ser Lys 
                725                 730                 735     


Leu Phe Ser Lys Glu Tyr Asp Ile Glu His Ile Ile Pro Lys Ala Arg 
            740                 745                 750         


Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Ile Cys Glu Arg Gln Leu 
        755                 760                 765             


Asn Ile Asp Lys Ala Asn Val Thr Ala Phe Ser Phe Leu Gln Asn Lys 
    770                 775                 780                 


Leu Ser Ala Asp Glu Phe Glu Gln Tyr Gln Ser Arg Val Lys Ser Leu 
785                 790                 795                 800 


Tyr Gly Lys Leu Ser Lys Ala Lys Ile Gln Lys Leu Leu Met Ala Asn 
                805                 810                 815     


Asp Lys Ile Pro Glu Asp Phe Ile Ala Arg Gln Leu Gln Glu Thr Arg 
            820                 825                 830         


Tyr Ile Ser Lys Lys Ala Lys Glu Ile Leu Phe Glu Ile Ser Arg Arg 
        835                 840                 845             


Val Ser Val Thr Thr Gly Thr Ile Thr Asp Lys Leu Arg Glu Asp Trp 
    850                 855                 860                 


Gly Leu Val Glu Ile Met Lys Glu Leu Asn Trp Glu Lys Tyr Asp Lys 
865                 870                 875                 880 


Leu Gly Leu Thr Tyr Thr Ile Glu Gly Lys His Gly Glu Arg Leu Asn 
                885                 890                 895     


Lys Ile Lys Asp Trp Ser Lys Arg Asn Asp His Arg His His Ala Met 
            900                 905                 910         


Asp Ala Leu Thr Val Ala Leu Thr Lys Pro Ala Tyr Ile Gln Tyr Leu 
        915                 920                 925             


Asn Asn Leu Asn Ala Lys Gly Leu Asn Asn Lys Lys Gly Thr Glu Val 
    930                 935                 940                 


Phe Ala Ile Glu Gln Lys Tyr Leu Lys Arg Glu Asn Gly Lys Leu Cys 
945                 950                 955                 960 


Phe Ile Pro Pro Ile Glu Asn Ile Arg Ser Glu Ala Lys Lys His Leu 
                965                 970                 975     


Ser Arg Ile Leu Val Ser Tyr Lys Ala Lys Asn Lys Val Val Thr Ile 
            980                 985                 990         


Asn Lys Asn Lys Thr Lys Ser Lys  Ala Gly Leu Asn Glu  Gln Ile Ala 
        995                 1000                 1005             


Leu Thr  Pro Arg Gly Gln Leu  His Lys Glu Thr Val  Tyr Gly Lys 
    1010                 1015                 1020             


Ser Phe  His Tyr Ser Thr Lys  Phe Glu Lys Ile Gly  Ala Ser Phe 
    1025                 1030                 1035             


Asn Val  Gln Lys Ile Asn Thr  Val Ala Lys Lys Glu  Glu Arg Glu 
    1040                 1045                 1050             


Ala Leu  Leu Lys Arg Leu Ala  Glu Asn Gly Asn Asp  Pro Lys Lys 
    1055                 1060                 1065             


Ala Phe  Thr Gly Lys Asn Thr  Leu Asn Lys Met Pro  Ile Tyr Leu 
    1070                 1075                 1080             


Asp Leu  Gly Lys Asn Ile Lys  Leu Ser Glu Lys Val  Lys Thr Val 
    1085                 1090                 1095             


Val Leu  Glu Gln Asn Tyr Thr  Ile Arg Lys Asn Ile  Asp Pro Asp 
    1100                 1105                 1110             


Leu Lys  Val Asp Lys Val Ile  Asp Val Gly Ile Lys  Arg Ile Leu 
    1115                 1120                 1125             


Glu Ser  Arg Leu Glu Glu Phe  Gly Gly Asn Ala Lys  Leu Ala Phe 
    1130                 1135                 1140             


Ser Asn  Leu Glu Glu Asn Pro  Ile Trp Leu Asn Lys  Glu Lys Gly 
    1145                 1150                 1155             


Ile Ser  Ile Lys Arg Val Lys  Ile Ser Gly Val Ser  Asn Val Glu 
    1160                 1165                 1170             


Ser Leu  His Val Lys Lys Asp  His Phe Gly Glu Pro  Ile Leu Asp 
    1175                 1180                 1185             


Gln Glu  Gly Asn Glu Ile Pro  Val Asp Phe Val Ser  Thr Gly Asn 
    1190                 1195                 1200             


Asn His  His Val Ala Ile Tyr  Glu Asp Glu Asn Gly  Asn Leu Gln 
    1205                 1210                 1215             


Glu Glu  Val Val Ser Phe Phe  Glu Ala Val Val Arg  Gln Asn Gln 
    1220                 1225                 1230             


Gly Leu  Pro Ile Ile Lys Lys  Asn His Thr Leu Gly  Trp Lys Phe 
    1235                 1240                 1245             


Leu Phe  Thr Leu Lys Gln Asn  Glu Tyr Phe Val Phe  Pro Ser Asp 
    1250                 1255                 1260             


Asp Phe  Val Pro Ala Asp Val  Asp Leu Met Asp Glu  Gln Asn Tyr 
    1265                 1270                 1275             


His Leu  Ile Ser Pro Asn Leu  Phe Arg Val Gln Lys  Ile Ala Arg 
    1280                 1285                 1290             


Lys Asn  Tyr Val Phe Asn Asn  His Leu Glu Thr Lys  Ala Val Asp 
    1295                 1300                 1305             


Asn Asp  Leu Leu Lys Ser Lys  Lys Glu Leu Ser Lys  Ile Thr Tyr 
    1310                 1315                 1320             


His Phe  Tyr Gln Thr Pro Glu  His Leu Arg Gly Ile  Ile Lys Ile 
    1325                 1330                 1335             


Arg Ile  Asn His Leu Gly Lys  Ile Ile Gln Ile Gly  Glu Tyr 
    1340                 1345                 1350         


<210> 92
<211> 1415
<212> PRT
<213> Bergeyella zoohelcum


<220>
<223> Bergeyella zoohelcum ATCC 43767

<400> 92
Met Lys His Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Ile Glu Arg Asn Ile Glu Glu Lys Tyr Gly Lys Ile Ile Gly 
            20                  25                  30          


Met Gly Ser Arg Ile Val Pro Met Gly Ala Glu Leu Ser Lys Phe Glu 
        35                  40                  45              


Gln Gly Gln Ala Gln Thr Lys Asn Ala Asp Arg Arg Thr Asn Arg Gly 
    50                  55                  60                  


Ala Arg Arg Leu Asn Lys Arg Tyr Lys Gln Arg Arg Asn Lys Leu Ile 
65                  70                  75                  80  


Tyr Ile Leu Gln Lys Leu Asp Met Leu Pro Ser Gln Ile Lys Leu Lys 
                85                  90                  95      


Glu Asp Phe Ser Asp Pro Asn Lys Ile Asp Lys Ile Thr Ile Leu Pro 
            100                 105                 110         


Ile Ser Lys Lys Gln Glu Gln Leu Thr Ala Phe Asp Leu Val Ser Leu 
        115                 120                 125             


Arg Val Lys Ala Leu Thr Glu Lys Val Gly Leu Glu Asp Leu Gly Lys 
    130                 135                 140                 


Ile Ile Tyr Lys Tyr Asn Gln Leu Arg Gly Tyr Ala Gly Gly Ser Leu 
145                 150                 155                 160 


Glu Pro Glu Lys Glu Asp Ile Phe Asp Glu Glu Gln Ser Lys Asp Lys 
                165                 170                 175     


Lys Asn Lys Ser Phe Ile Ala Phe Ser Lys Ile Val Phe Leu Gly Glu 
            180                 185                 190         


Pro Gln Glu Glu Ile Phe Lys Asn Lys Lys Leu Asn Arg Arg Ala Ile 
        195                 200                 205             


Ile Val Glu Thr Glu Glu Gly Asn Phe Glu Gly Ser Thr Phe Leu Glu 
    210                 215                 220                 


Asn Ile Lys Val Gly Asp Ser Leu Glu Leu Leu Ile Asn Ile Ser Ala 
225                 230                 235                 240 


Ser Lys Ser Gly Asp Thr Ile Thr Ile Lys Leu Pro Asn Lys Thr Asn 
                245                 250                 255     


Trp Arg Lys Lys Met Glu Asn Ile Glu Asn Gln Leu Lys Glu Lys Ser 
            260                 265                 270         


Lys Glu Met Gly Arg Glu Phe Tyr Ile Ser Glu Phe Leu Leu Glu Leu 
        275                 280                 285             


Leu Lys Glu Asn Arg Trp Ala Lys Ile Arg Asn Asn Thr Ile Leu Arg 
    290                 295                 300                 


Ala Arg Tyr Glu Ser Glu Phe Glu Ala Ile Trp Asn Glu Gln Val Lys 
305                 310                 315                 320 


His Tyr Pro Phe Leu Glu Asn Leu Asp Lys Lys Thr Leu Ile Glu Ile 
                325                 330                 335     


Val Ser Phe Ile Phe Pro Gly Glu Lys Glu Ser Gln Lys Lys Tyr Arg 
            340                 345                 350         


Glu Leu Gly Leu Glu Lys Gly Leu Lys Tyr Ile Ile Lys Asn Gln Val 
        355                 360                 365             


Val Phe Tyr Gln Arg Glu Leu Lys Asp Gln Ser His Leu Ile Ser Asp 
    370                 375                 380                 


Cys Arg Tyr Glu Pro Asn Glu Lys Ala Ile Ala Lys Ser His Pro Val 
385                 390                 395                 400 


Phe Gln Glu Tyr Lys Val Trp Glu Gln Ile Asn Lys Leu Ile Val Asn 
                405                 410                 415     


Thr Lys Ile Glu Ala Gly Thr Asn Arg Lys Gly Glu Lys Lys Tyr Lys 
            420                 425                 430         


Tyr Ile Asp Arg Pro Ile Pro Thr Ala Leu Lys Glu Trp Ile Phe Glu 
        435                 440                 445             


Glu Leu Gln Asn Lys Lys Glu Ile Thr Phe Ser Ala Ile Phe Lys Lys 
    450                 455                 460                 


Leu Lys Ala Glu Phe Asp Leu Arg Glu Gly Ile Asp Phe Leu Asn Gly 
465                 470                 475                 480 


Met Ser Pro Lys Asp Lys Leu Lys Gly Asn Glu Thr Lys Leu Gln Leu 
                485                 490                 495     


Gln Lys Ser Leu Gly Glu Leu Trp Asp Val Leu Gly Leu Asp Ser Ile 
            500                 505                 510         


Asn Arg Gln Ile Glu Leu Trp Asn Ile Leu Tyr Asn Glu Lys Gly Asn 
        515                 520                 525             


Glu Tyr Asp Leu Thr Ser Asp Arg Thr Ser Lys Val Leu Glu Phe Ile 
    530                 535                 540                 


Asn Lys Tyr Gly Asn Asn Ile Val Asp Asp Asn Ala Glu Glu Thr Ala 
545                 550                 555                 560 


Ile Arg Ile Ser Lys Ile Lys Phe Ala Arg Ala Tyr Ser Ser Leu Ser 
                565                 570                 575     


Leu Lys Ala Val Glu Arg Ile Leu Pro Leu Val Arg Ala Gly Lys Tyr 
            580                 585                 590         


Phe Asn Asn Asp Phe Ser Gln Gln Leu Gln Ser Lys Ile Leu Lys Leu 
        595                 600                 605             


Leu Asn Glu Asn Val Glu Asp Pro Phe Ala Lys Ala Ala Gln Thr Tyr 
    610                 615                 620                 


Leu Asp Asn Asn Gln Ser Val Leu Ser Glu Gly Gly Val Gly Asn Ser 
625                 630                 635                 640 


Ile Ala Thr Ile Leu Val Tyr Asp Lys His Thr Ala Lys Glu Tyr Ser 
                645                 650                 655     


His Asp Glu Leu Tyr Lys Ser Tyr Lys Glu Ile Asn Leu Leu Lys Gln 
            660                 665                 670         


Gly Asp Leu Arg Asn Pro Leu Val Glu Gln Ile Ile Asn Glu Ala Leu 
        675                 680                 685             


Val Leu Ile Arg Asp Ile Trp Lys Asn Tyr Gly Ile Lys Pro Asn Glu 
    690                 695                 700                 


Ile Arg Val Glu Leu Ala Arg Asp Leu Lys Asn Ser Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Thr Ile His Lys Arg Asn Lys Asp Asn Gln Thr Ile Asn Asn Lys 
                725                 730                 735     


Ile Lys Glu Thr Leu Val Lys Asn Lys Lys Glu Leu Ser Leu Ala Asn 
            740                 745                 750         


Ile Glu Lys Val Lys Leu Trp Glu Ala Gln Arg His Leu Ser Pro Tyr 
        755                 760                 765             


Thr Gly Gln Pro Ile Pro Leu Ser Asp Leu Phe Asp Lys Glu Lys Tyr 
    770                 775                 780                 


Asp Val Asp His Ile Ile Pro Ile Ser Arg Tyr Phe Asp Asp Ser Phe 
785                 790                 795                 800 


Thr Asn Lys Val Ile Ser Glu Lys Ser Val Asn Gln Glu Lys Ala Asn 
                805                 810                 815     


Arg Thr Ala Met Glu Tyr Phe Glu Val Gly Ser Leu Lys Tyr Ser Ile 
            820                 825                 830         


Phe Thr Lys Glu Gln Phe Ile Ala His Val Asn Glu Tyr Phe Ser Gly 
        835                 840                 845             


Val Lys Arg Lys Asn Leu Leu Ala Thr Ser Ile Pro Glu Asp Pro Val 
    850                 855                 860                 


Gln Arg Gln Ile Lys Asp Thr Gln Tyr Ile Ala Ile Arg Val Lys Glu 
865                 870                 875                 880 


Glu Leu Asn Lys Ile Val Gly Asn Glu Asn Val Lys Thr Thr Thr Gly 
                885                 890                 895     


Ser Ile Thr Asp Tyr Leu Arg Asn His Trp Gly Leu Thr Asp Lys Phe 
            900                 905                 910         


Lys Leu Leu Leu Lys Glu Arg Tyr Glu Ala Leu Leu Glu Ser Glu Lys 
        915                 920                 925             


Phe Leu Glu Ala Glu Tyr Asp Asn Tyr Lys Lys Asp Phe Asp Ser Arg 
    930                 935                 940                 


Lys Lys Glu Tyr Glu Glu Lys Glu Val Leu Phe Glu Glu Gln Glu Leu 
945                 950                 955                 960 


Thr Arg Glu Glu Phe Ile Lys Glu Tyr Lys Glu Asn Tyr Ile Arg Tyr 
                965                 970                 975     


Lys Lys Asn Lys Leu Ile Ile Lys Gly Trp Ser Lys Arg Ile Asp His 
            980                 985                 990         


Arg His His Ala Ile Asp Ala Leu  Ile Val Ala Cys Thr  Glu Pro Ala 
        995                 1000                 1005             


His Ile  Lys Arg Leu Asn Asp  Leu Asn Lys Val Leu  Gln Asp Trp 
    1010                 1015                 1020             


Leu Val  Glu His Lys Ser Glu  Phe Met Pro Asn Phe  Glu Gly Ser 
    1025                 1030                 1035             


Asn Ser  Glu Leu Leu Glu Glu  Ile Leu Ser Leu Pro  Glu Asn Glu 
    1040                 1045                 1050             


Arg Thr  Glu Ile Phe Thr Gln  Ile Glu Lys Phe Arg  Ala Ile Glu 
    1055                 1060                 1065             


Met Pro  Trp Lys Gly Phe Pro  Glu Gln Val Glu Gln  Lys Leu Lys 
    1070                 1075                 1080             


Glu Ile  Ile Ile Ser His Lys  Pro Lys Asp Lys Leu  Leu Leu Gln 
    1085                 1090                 1095             


Tyr Asn  Lys Ala Gly Asp Arg  Gln Ile Lys Leu Arg  Gly Gln Leu 
    1100                 1105                 1110             


His Glu  Gly Thr Leu Tyr Gly  Ile Ser Gln Gly Lys  Glu Ala Tyr 
    1115                 1120                 1125             


Arg Ile  Pro Leu Thr Lys Phe  Gly Gly Ser Lys Phe  Ala Thr Glu 
    1130                 1135                 1140             


Lys Asn  Ile Gln Lys Ile Val  Ser Pro Phe Leu Ser  Gly Phe Ile 
    1145                 1150                 1155             


Ala Asn  His Leu Lys Glu Tyr  Asn Asn Lys Lys Glu  Glu Ala Phe 
    1160                 1165                 1170             


Ser Ala  Glu Gly Ile Met Asp  Leu Asn Asn Lys Leu  Ala Gln Tyr 
    1175                 1180                 1185             


Arg Asn  Glu Lys Gly Glu Leu  Lys Pro His Thr Pro  Ile Ser Thr 
    1190                 1195                 1200             


Val Lys  Ile Tyr Tyr Lys Asp  Pro Ser Lys Asn Lys  Lys Lys Lys 
    1205                 1210                 1215             


Asp Glu  Glu Asp Leu Ser Leu  Gln Lys Leu Asp Arg  Glu Lys Ala 
    1220                 1225                 1230             


Phe Asn  Glu Lys Leu Tyr Val  Lys Thr Gly Asp Asn  Tyr Leu Phe 
    1235                 1240                 1245             


Ala Val  Leu Glu Gly Glu Ile  Lys Thr Lys Lys Thr  Ser Gln Ile 
    1250                 1255                 1260             


Lys Arg  Leu Tyr Asp Ile Ile  Ser Phe Phe Asp Ala  Thr Asn Phe 
    1265                 1270                 1275             


Leu Lys  Glu Glu Phe Arg Asn  Ala Pro Asp Lys Lys  Thr Phe Asp 
    1280                 1285                 1290             


Lys Asp  Leu Leu Phe Arg Gln  Tyr Phe Glu Glu Arg  Asn Lys Ala 
    1295                 1300                 1305             


Lys Leu  Leu Phe Thr Leu Lys  Gln Gly Asp Phe Val  Tyr Leu Pro 
    1310                 1315                 1320             


Asn Glu  Asn Glu Glu Val Ile  Leu Asp Lys Glu Ser  Pro Leu Tyr 
    1325                 1330                 1335             


Asn Gln  Tyr Trp Gly Asp Leu  Lys Glu Arg Gly Lys  Asn Ile Tyr 
    1340                 1345                 1350             


Val Val  Gln Lys Phe Ser Lys  Lys Gln Ile Tyr Phe  Ile Lys His 
    1355                 1360                 1365             


Thr Ile  Ala Asp Ile Ile Lys  Lys Asp Val Glu Phe  Gly Ser Gln 
    1370                 1375                 1380             


Asn Cys  Tyr Glu Thr Val Glu  Gly Arg Ser Ile Lys  Glu Asn Cys 
    1385                 1390                 1395             


Phe Lys  Leu Glu Ile Asp Arg  Leu Gly Asn Ile Val  Lys Val Ile 
    1400                 1405                 1410             


Lys Arg  
    1415 


<210> 93
<211> 1430
<212> PRT
<213> Bergeyella zoohelcum


<220>
<223> Bergeyella zoohelcum CCUG 30536

<400> 93
Met Lys His Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Val Lys Glu Ala Gln Asn Asp Asn Glu Gln Ser Glu Ile Val 
            20                  25                  30          


Asp Val Gly Val Arg Val Asn Pro Leu Thr Thr Asp Glu Lys Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Pro Ile Ser Thr Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Ser Ala Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Lys Glu 
65                  70                  75                  80  


Leu Ile Glu Leu Leu Lys Glu His Gln Leu Ile Ser Thr Asp Thr Ile 
                85                  90                  95      


Leu Thr Glu Asn Gly Lys Gly Thr Thr Phe Gln Thr Leu Glu Leu Arg 
            100                 105                 110         


Ala Lys Ser Ala Lys Glu Lys Ile Ser Leu Glu Glu Leu Ala Arg Val 
        115                 120                 125             


Phe Leu Thr Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Asn Glu Asp Glu Gly Gln Leu Ile Asp Gly Met Glu Ile Ala Lys 
145                 150                 155                 160 


Arg Leu Tyr Glu Glu Asn Leu Thr Thr Gly Gln Leu Ser Leu Gln Leu 
                165                 170                 175     


Leu Lys Glu Gly Lys Lys Ser Leu Pro Asp Tyr Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Phe Glu Leu Asp Lys Val Trp Asn Phe Gln Lys Gln Phe His Ser 
        195                 200                 205             


Asp Ile Leu Thr Asp Glu Phe Tyr Ala Gln Leu Lys Gly Lys Gly Gln 
    210                 215                 220                 


Arg Ala Thr Ser Ala Leu Phe Leu Ala Lys Tyr Gln Ile Tyr Thr Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Ser Arg Glu Asp Lys Lys Leu Gln Ala Tyr Gln Trp 
                245                 250                 255     


Arg Val Asp Ala Leu Ser Lys Glu Leu Thr Arg Glu Gln Leu Ala Phe 
            260                 265                 270         


Val Ile Thr Glu Ile Asn Asn Asn Leu Asn Asn Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Asn Glu Thr 
    290                 295                 300                 


Val Gly Glu Tyr Leu Trp Lys Gln Ile Ala Ala Asn Pro His Thr Ser 
305                 310                 315                 320 


Leu Lys Asn Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Gln Ile Trp Lys Thr Gln Ser Ala Phe Tyr Pro Glu Ile Leu Thr Asp 
            340                 345                 350         


Glu Leu Lys Lys Glu Leu Arg Asp Val Val Ile Phe Tyr Gln Arg Lys 
        355                 360                 365             


Leu Lys Ser Gln Lys Ser Leu Val Ser Phe Cys Glu Phe Glu Asn Lys 
    370                 375                 380                 


Glu Ile Glu Ile Lys Lys Glu Asp Gly Thr Ser Thr Lys Lys Val Ile 
385                 390                 395                 400 


Gly Leu Lys Val Ala Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys 
                405                 410                 415     


Ile Trp Gln Asn Leu Asn Asn Val Leu Ile Arg Lys Lys Gly Ser Lys 
            420                 425                 430         


Thr Lys Lys Val Ala Lys Asn Gln Gln Ala Val Leu Phe Glu Glu Glu 
        435                 440                 445             


Lys Thr Ile Ser Glu Leu Asp Leu Glu Ala Lys Gln Ala Leu Phe Asn 
    450                 455                 460                 


Glu Leu Asn Leu Lys Gly Asn Leu Lys Ala Asp Tyr Cys Leu Glu Ile 
465                 470                 475                 480 


Leu Gly Tyr Ser Pro Lys Glu Trp Glu Met Asn Tyr Ser Val Leu Glu 
                485                 490                 495     


Gly Asn Arg Thr Asn Lys Ala Leu Tyr Glu Ala Tyr Leu Lys Ile Thr 
            500                 505                 510         


Asp Leu Glu Gly Tyr Asp Ala Lys Asn His Leu Lys Val Lys Leu Asn 
        515                 520                 525             


Lys Asp Glu Val Glu Leu Asp Asp Leu Lys Val Pro Ala Ser Glu Ile 
    530                 535                 540                 


Lys Asp Met Val Gln Ala Ile Phe Lys Glu Ala Gly Ile Asn Thr Asp 
545                 550                 555                 560 


Ile Leu His Phe Asn Ala Glu Leu Asp Gly Lys Asp Phe Glu Asn Gln 
                565                 570                 575     


Ala Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser Tyr Glu Gly Asp Asp 
            580                 585                 590         


Ser Lys Ser Gly Asn Glu Leu Leu Tyr Lys Leu Leu Glu Thr Lys Phe 
        595                 600                 605             


Gly Phe Lys Lys Glu Tyr Ala Gln Ile Leu Ala Asn Val Ser Leu Ser 
    610                 615                 620                 


Asp Asp Tyr Gly Ser Leu Ser Thr Lys Ala Met Arg Lys Ile His Pro 
625                 630                 635                 640 


Tyr Ile Lys Glu Asn Lys Phe Ser Thr Ala Cys Glu Leu Ala Gly Tyr 
                645                 650                 655     


Arg His Ser Lys His Ser Leu Thr Lys Glu Glu Asn Asp Asn Arg Val 
            660                 665                 670         


Leu Lys Asp Ser Leu Glu Val Leu Lys Lys Asn Ser Leu Arg Gln Pro 
        675                 680                 685             


Val Val Glu Lys Ile Leu Asn Gln Met Ile Asn Leu Val Asn Ala Leu 
    690                 695                 700                 


Leu Lys Lys Tyr Arg Thr Glu Asn Pro Asn Phe Lys Phe Asp Glu Ile 
705                 710                 715                 720 


Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn Ala Glu Glu Arg Ala 
                725                 730                 735     


Asn Met Thr Ala Asn Ile Asn Lys Ala Lys Thr Glu His Glu Lys Ile 
            740                 745                 750         


Ile Lys Ile Leu Lys Asn Glu Phe Gly Leu Pro Asn Pro Thr Arg Asn 
        755                 760                 765             


Asp Ile Ile Arg Tyr Arg Leu Tyr Glu Glu Leu Lys Ala Asn Gly Tyr 
    770                 775                 780                 


Lys Asp Leu Tyr Thr Asn Ile Lys Ile Pro Gln Glu Lys Leu Phe Thr 
785                 790                 795                 800 


Lys Glu Ile Asp Ile Glu His Ile Ile Pro Lys Ser Arg Val Phe Asp 
                805                 810                 815     


Asp Ser Phe Ser Asn Lys Thr Leu Ser Phe Arg Lys Thr Asn Leu Asp 
            820                 825                 830         


Lys Gly Glu Arg Thr Ala Phe Asp Tyr Met Glu Ser Lys Phe Gly Ala 
        835                 840                 845             


Asp Lys Leu Glu Glu Tyr Val Ala Arg Val Glu Asp Leu Tyr Lys Asn 
    850                 855                 860                 


Asn Ile Ile Ser Lys Ala Lys Tyr Gln Lys Leu Leu Lys Lys Glu Ser 
865                 870                 875                 880 


Glu Ile Gly Asp Gly Phe Val Glu Arg Asp Leu Arg Glu Thr Gln Tyr 
                885                 890                 895     


Ile Ala Lys Lys Ala Lys Glu Ile Leu Leu Gln Ile Thr Pro Asn Val 
            900                 905                 910         


Leu Ser Thr Ser Gly Gly Ile Thr Asp Arg Leu Arg Glu Asp Trp Asp 
        915                 920                 925             


Leu Ile Asn Val Met Lys Glu Leu Asn Leu Pro Lys Tyr Arg Ala Leu 
    930                 935                 940                 


Gly Leu Thr Gln Met Glu Asp Arg Lys Tyr Gly Gln Gln Val Glu Val 
945                 950                 955                 960 


Ile Thr Asp Trp Thr Lys Arg Asn Asp His Arg His His Ala Met Asp 
                965                 970                 975     


Ala Leu Thr Val Ala Phe Thr Lys His Asn His Ile Gln Tyr Leu Asn 
            980                 985                 990         


Tyr Leu Asn Ala Arg Lys Asn Glu  Lys His Lys Glu His  Ser Asn Ile 
        995                 1000                 1005             


Met Gly  Ile Gln Gln Leu Glu  Thr Ile Lys Val Thr  Asp Lys Asn 
    1010                 1015                 1020             


Gly Asn  Glu Lys Arg Val Phe  Lys Ala Pro Met Pro  Asn Phe Arg 
    1025                 1030                 1035             


Gln Val  Thr Lys Ala Phe Leu  Glu Asn Ile Leu Ile  Ser His Lys 
    1040                 1045                 1050             


Ala Lys  Asn Lys Val Val Thr  Lys Asn Lys Asn Lys  Val Ala Gly 
    1055                 1060                 1065             


Ser Asn  Lys Val Gln Glu Val  Leu Thr Pro Arg Gly  Gln Leu His 
    1070                 1075                 1080             


Lys Glu  Thr Val Tyr Gly Lys  Tyr Gln Tyr Tyr Val  Gln Lys Glu 
    1085                 1090                 1095             


Glu Lys  Ile Gly Ala Lys Phe  Asp Leu Glu Thr Ile  Lys Lys Val 
    1100                 1105                 1110             


Ala Asn  Pro Leu Tyr Gln Ser  Leu Leu Lys Lys Arg  Leu Glu Glu 
    1115                 1120                 1125             


Asn Gly  Gly Asp Pro Lys Lys  Ala Phe Thr Gly Lys  Asn Ser Leu 
    1130                 1135                 1140             


Ala Lys  Asn Pro Ile Tyr Leu  Asp Asp Thr Gln Thr  Glu Gln Leu 
    1145                 1150                 1155             


Pro Glu  Lys Val Lys Leu Val  Trp Leu Glu Asn Ser  Phe Ser Ile 
    1160                 1165                 1170             


Arg Lys  Asp Ile Thr Pro Glu  Asn Phe Lys Asp Glu  Lys Leu Ile 
    1175                 1180                 1185             


Asp Lys  Ile Leu Asp Glu Gly  Val Lys Arg Ile Leu  Lys Glu Arg 
    1190                 1195                 1200             


Leu Gln  Ser Phe Gly Asn Asp  Ala Lys Lys Ala Phe  Ser Asp Leu 
    1205                 1210                 1215             


Asp Lys  Asn Pro Ile Trp Leu  Asn Lys Glu Lys Gly  Ile Thr Ile 
    1220                 1225                 1230             


Lys Arg  Val Thr Ile Ser Gly  Val Ala Asn Ala Glu  Pro Leu His 
    1235                 1240                 1245             


Thr Lys  Lys Asp His Leu Gly  Lys Glu Ile Leu Asp  Lys Glu Gly 
    1250                 1255                 1260             


Lys Pro  Ile Pro Val Asp Phe  Ile Ser Thr Gly Ser  Asn His His 
    1265                 1270                 1275             


Val Ala  Val Tyr Arg Asp Glu  Lys Gly Asn Leu Gln  Glu Lys Val 
    1280                 1285                 1290             


Val Ser  Val Phe Glu Ala Val  Val Arg Ala Asn Gln  Gly Leu Pro 
    1295                 1300                 1305             


Ile Ile  Asp Lys Thr Tyr Asn  Gln His Leu Gly Trp  Glu Phe Leu 
    1310                 1315                 1320             


Phe Thr  Met Lys Gln Asn Glu  Met Phe Val Phe Pro  Asn Glu Ser 
    1325                 1330                 1335             


Thr Gly  Phe Asn Pro Asn Asp  Ile Asp Leu Leu Asp  Pro Lys Asn 
    1340                 1345                 1350             


Lys Arg  Ile Ile Ser Pro Asn  Leu Phe Arg Val Gln  Lys Phe Ser 
    1355                 1360                 1365             


Lys Leu  Gln Tyr Gly Asn Ser  Phe Val Arg Glu Phe  Val Phe Arg 
    1370                 1375                 1380             


His His  Leu Glu Thr Thr Val  Glu Asp Arg Lys Glu  Leu Gln Gly 
    1385                 1390                 1395             


Ile Thr  Tyr Lys Gln Met Lys  Asn Ser Thr Phe Phe  Asn Asp Ile 
    1400                 1405                 1410             


Ile Lys  Val Arg Ile Asn His  Leu Gly Asp Ile Val  Ser Ile Gly 
    1415                 1420                 1425             


Glu Tyr  
    1430 


<210> 94
<211> 1420
<212> PRT
<213> Bifidobacterium bifidum

<400> 94
Met Ser Arg Lys Asn Tyr Val Asp Asp Tyr Ala Ile Ser Leu Asp Ile 
1               5                   10                  15      


Gly Asn Ala Ser Val Gly Trp Ser Ala Phe Thr Pro Asn Tyr Arg Leu 
            20                  25                  30          


Val Arg Ala Lys Gly His Glu Leu Ile Gly Val Arg Leu Phe Asp Pro 
        35                  40                  45              


Ala Asp Thr Ala Glu Ser Arg Arg Met Ala Arg Thr Thr Arg Arg Arg 
    50                  55                  60                  


Tyr Ser Arg Arg Arg Trp Arg Leu Arg Leu Leu Asp Ala Leu Phe Asp 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Ile Asp Pro Ser Phe Leu Ala Arg Arg Lys Tyr 
                85                  90                  95      


Ser Trp Val His Pro Asp Asp Glu Asn Asn Ala Asp Cys Trp Tyr Gly 
            100                 105                 110         


Ser Val Leu Phe Asp Ser Asn Glu Gln Asp Lys Arg Phe Tyr Glu Lys 
        115                 120                 125             


Tyr Pro Thr Ile Tyr His Leu Arg Lys Ala Leu Met Glu Asp Asp Ser 
    130                 135                 140                 


Gln His Asp Ile Arg Glu Ile Tyr Leu Ala Ile His His Met Val Lys 
145                 150                 155                 160 


Tyr Arg Gly Asn Phe Leu Val Glu Gly Thr Leu Glu Ser Ser Asn Ala 
                165                 170                 175     


Phe Lys Glu Asp Glu Leu Leu Lys Leu Leu Gly Arg Ile Thr Arg Tyr 
            180                 185                 190         


Glu Met Ser Glu Gly Glu Gln Asn Ser Asp Ile Glu Gln Asp Asp Glu 
        195                 200                 205             


Asn Lys Leu Val Ala Pro Ala Asn Gly Gln Leu Ala Asp Ala Leu Cys 
    210                 215                 220                 


Ala Thr Arg Gly Ser Arg Ser Met Arg Val Asp Asn Ala Leu Glu Ala 
225                 230                 235                 240 


Leu Ser Ala Val Asn Asp Leu Ser Arg Glu Gln Arg Ala Ile Val Lys 
                245                 250                 255     


Ala Ile Phe Ala Gly Leu Glu Gly Asn Lys Leu Asp Leu Ala Lys Ile 
            260                 265                 270         


Phe Val Ser Lys Glu Phe Ser Ser Glu Asn Lys Lys Ile Leu Gly Ile 
        275                 280                 285             


Tyr Phe Asn Lys Ser Asp Tyr Glu Glu Lys Cys Val Gln Ile Val Asp 
    290                 295                 300                 


Ser Gly Leu Leu Asp Asp Glu Glu Arg Glu Phe Leu Asp Arg Met Gln 
305                 310                 315                 320 


Gly Gln Tyr Asn Ala Ile Ala Leu Lys Gln Leu Leu Gly Arg Ser Thr 
                325                 330                 335     


Ser Val Ser Asp Ser Lys Cys Ala Ser Tyr Asp Ala His Arg Ala Asn 
            340                 345                 350         


Trp Asn Leu Ile Lys Leu Gln Leu Arg Thr Lys Glu Asn Glu Lys Asp 
        355                 360                 365             


Ile Asn Glu Asn Tyr Gly Ile Leu Val Gly Trp Lys Ile Asp Ser Gly 
    370                 375                 380                 


Gln Arg Lys Ser Val Arg Gly Glu Ser Ala Tyr Glu Asn Met Arg Lys 
385                 390                 395                 400 


Lys Ala Asn Val Phe Phe Lys Lys Met Ile Glu Thr Ser Asp Leu Ser 
                405                 410                 415     


Glu Thr Asp Lys Asn Arg Leu Ile His Asp Ile Glu Glu Asp Lys Leu 
            420                 425                 430         


Phe Pro Ile Gln Arg Asp Ser Asp Asn Gly Val Ile Pro His Gln Leu 
        435                 440                 445             


His Gln Asn Glu Leu Lys Gln Ile Ile Lys Lys Gln Gly Lys Tyr Tyr 
    450                 455                 460                 


Pro Phe Leu Leu Asp Ala Phe Glu Lys Asp Gly Lys Gln Ile Asn Lys 
465                 470                 475                 480 


Ile Glu Gly Leu Leu Thr Phe Arg Val Pro Tyr Phe Val Gly Pro Leu 
                485                 490                 495     


Val Val Pro Glu Asp Leu Gln Lys Ser Asp Asn Ser Glu Asn His Trp 
            500                 505                 510         


Met Val Arg Lys Lys Lys Gly Glu Ile Thr Pro Trp Asn Phe Asp Glu 
        515                 520                 525             


Met Val Asp Lys Asp Ala Ser Gly Arg Lys Phe Ile Glu Arg Leu Val 
    530                 535                 540                 


Gly Thr Asp Ser Tyr Leu Leu Gly Glu Pro Thr Leu Pro Lys Asn Ser 
545                 550                 555                 560 


Leu Leu Tyr Gln Glu Tyr Glu Val Leu Asn Glu Leu Asn Asn Val Arg 
                565                 570                 575     


Leu Ser Val Arg Thr Gly Asn His Trp Asn Asp Lys Arg Arg Met Arg 
            580                 585                 590         


Leu Gly Arg Glu Glu Lys Thr Leu Leu Cys Gln Arg Leu Phe Met Lys 
        595                 600                 605             


Gly Gln Thr Val Thr Lys Arg Thr Ala Glu Asn Leu Leu Arg Lys Glu 
    610                 615                 620                 


Tyr Gly Arg Thr Tyr Glu Leu Ser Gly Leu Ser Asp Glu Ser Lys Phe 
625                 630                 635                 640 


Thr Ser Ser Leu Ser Thr Tyr Gly Lys Met Cys Arg Ile Phe Gly Glu 
                645                 650                 655     


Lys Tyr Val Asn Glu His Arg Asp Leu Met Glu Lys Ile Val Glu Leu 
            660                 665                 670         


Gln Thr Val Phe Glu Asp Lys Glu Thr Leu Leu His Gln Leu Arg Gln 
        675                 680                 685             


Leu Glu Gly Ile Ser Glu Ala Asp Cys Ala Leu Leu Val Asn Thr His 
    690                 695                 700                 


Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Leu Thr Thr Lys Ala 
705                 710                 715                 720 


Gly Glu Cys Lys Ile Ser Asp Asp Phe Ala Pro Arg Lys His Ser Ile 
                725                 730                 735     


Ile Glu Ile Met Arg Ala Glu Asp Arg Asn Leu Met Glu Ile Ile Thr 
            740                 745                 750         


Asp Lys Gln Leu Gly Phe Ser Asp Trp Ile Glu Gln Glu Asn Leu Gly 
        755                 760                 765             


Ala Glu Asn Gly Ser Ser Leu Met Glu Val Val Asp Asp Leu Arg Val 
    770                 775                 780                 


Ser Pro Lys Val Lys Arg Gly Ile Ile Gln Ser Ile Arg Leu Ile Asp 
785                 790                 795                 800 


Asp Ile Ser Lys Ala Val Gly Lys Arg Pro Ser Arg Ile Phe Leu Glu 
                805                 810                 815     


Leu Ala Asp Asp Ile Gln Pro Ser Gly Arg Thr Ile Ser Arg Lys Ser 
            820                 825                 830         


Arg Leu Gln Asp Leu Tyr Arg Asn Ala Asn Leu Gly Lys Glu Phe Lys 
        835                 840                 845             


Gly Ile Ala Asp Glu Leu Asn Ala Cys Ser Asp Lys Asp Leu Gln Asp 
    850                 855                 860                 


Asp Arg Leu Phe Leu Tyr Tyr Thr Gln Leu Gly Lys Asp Met Tyr Thr 
865                 870                 875                 880 


Gly Glu Glu Leu Asp Leu Asp Arg Leu Ser Ser Ala Tyr Asp Ile Asp 
                885                 890                 895     


His Ile Ile Pro Gln Ala Val Thr Gln Asn Asp Ser Ile Asp Asn Arg 
            900                 905                 910         


Val Leu Val Ala Arg Ala Glu Asn Ala Arg Lys Thr Asp Ser Phe Thr 
        915                 920                 925             


Tyr Met Pro Gln Ile Ala Asp Arg Met Arg Asn Phe Trp Gln Ile Leu 
    930                 935                 940                 


Leu Asp Asn Gly Leu Ile Ser Arg Val Lys Phe Glu Arg Leu Thr Arg 
945                 950                 955                 960 


Gln Asn Glu Phe Ser Glu Arg Glu Lys Glu Arg Phe Val Gln Arg Ser 
                965                 970                 975     


Leu Val Glu Thr Arg Gln Ile Met Lys Asn Val Ala Thr Leu Met Arg 
            980                 985                 990         


Gln Arg Tyr Gly Asn Ser Ala Ala  Val Ile Gly Leu Asn  Ala Glu Leu 
        995                 1000                 1005             


Thr Lys  Glu Met His Arg Tyr  Leu Gly Phe Ser His  Lys Asn Arg 
    1010                 1015                 1020             


Asp Ile  Asn Asp Tyr His His  Ala Gln Asp Ala Leu  Cys Val Gly 
    1025                 1030                 1035             


Ile Ala  Gly Gln Phe Ala Ala  Asn Arg Gly Phe Phe  Ala Asp Gly 
    1040                 1045                 1050             


Glu Val  Ser Asp Gly Ala Gln  Asn Ser Tyr Asn Gln  Tyr Leu Arg 
    1055                 1060                 1065             


Asp Tyr  Leu Arg Gly Tyr Arg  Glu Lys Leu Ser Ala  Glu Asp Arg 
    1070                 1075                 1080             


Lys Gln  Gly Arg Ala Phe Gly  Phe Ile Val Gly Ser  Met Arg Ser 
    1085                 1090                 1095             


Gln Asp  Glu Gln Lys Arg Val  Asn Pro Arg Thr Gly  Glu Val Val 
    1100                 1105                 1110             


Trp Ser  Glu Glu Asp Lys Asp  Tyr Leu Arg Lys Val  Met Asn Tyr 
    1115                 1120                 1125             


Arg Lys  Met Leu Val Thr Gln  Lys Val Gly Asp Asp  Phe Gly Ala 
    1130                 1135                 1140             


Leu Tyr  Asp Glu Thr Arg Tyr  Ala Ala Thr Asp Pro  Lys Gly Ile 
    1145                 1150                 1155             


Lys Gly  Ile Pro Phe Asp Gly  Ala Lys Gln Asp Thr  Ser Leu Tyr 
    1160                 1165                 1170             


Gly Gly  Phe Ser Ser Ala Lys  Pro Ala Tyr Ala Val  Leu Ile Glu 
    1175                 1180                 1185             


Ser Lys  Gly Lys Thr Arg Leu  Val Asn Val Thr Met  Gln Glu Tyr 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Arg Pro  Ser Asp Asp Glu Leu  Arg Lys Val 
    1205                 1210                 1215             


Leu Ala  Lys Lys Lys Ser Glu  Tyr Ala Lys Ala Asn  Ile Leu Leu 
    1220                 1225                 1230             


Arg His  Val Pro Lys Met Gln  Leu Ile Arg Tyr Gly  Gly Gly Leu 
    1235                 1240                 1245             


Met Val  Ile Lys Ser Ala Gly  Glu Leu Asn Asn Ala  Gln Gln Leu 
    1250                 1255                 1260             


Trp Leu  Pro Tyr Glu Glu Tyr  Cys Tyr Phe Asp Asp  Leu Ser Gln 
    1265                 1270                 1275             


Gly Lys  Gly Ser Leu Glu Lys  Asp Asp Leu Lys Lys  Leu Leu Asp 
    1280                 1285                 1290             


Ser Ile  Leu Gly Ser Val Gln  Cys Leu Tyr Pro Trp  His Arg Phe 
    1295                 1300                 1305             


Thr Glu  Glu Glu Leu Ala Asp  Leu His Val Ala Phe  Asp Lys Leu 
    1310                 1315                 1320             


Pro Glu  Asp Glu Lys Lys Asn  Val Ile Thr Gly Ile  Val Ser Ala 
    1325                 1330                 1335             


Leu His  Ala Asp Ala Lys Thr  Ala Asn Leu Ser Ile  Val Gly Met 
    1340                 1345                 1350             


Thr Gly  Ser Trp Arg Arg Met  Asn Asn Lys Ser Gly  Tyr Thr Phe 
    1355                 1360                 1365             


Ser Asp  Glu Asp Glu Phe Ile  Phe Gln Ser Pro Ser  Gly Leu Phe 
    1370                 1375                 1380             


Glu Lys  Arg Val Thr Val Gly  Glu Leu Lys Arg Lys  Ala Lys Lys 
    1385                 1390                 1395             


Glu Val  Asn Ser Lys Tyr Arg  Thr Asn Glu Lys Arg  Leu Pro Thr 
    1400                 1405                 1410             


Leu Ser  Gly Ala Ser Gln Pro  
    1415                 1420 


<210> 95
<211> 1138
<212> PRT
<213> Bifidobacterium dentium

<400> 95
Met Leu Cys Arg Cys His Arg Arg Tyr Arg Ile Gly Ile Asp Val Gly 
1               5                   10                  15      


Leu Met Ser Val Gly Leu Ala Ala Ile Glu Val Asp Glu Thr Gly Phe 
            20                  25                  30          


Pro Ile Arg Ile Leu Asn Ile Gln Ser Val Ile His Asp Gly Gly Ile 
        35                  40                  45              


Asp Pro Gln Leu Gly Lys Lys Lys Ser Ile Ser Arg Lys Ala Ile Ser 
    50                  55                  60                  


Gly Val Ala Arg Arg Thr Arg Arg Met Arg Arg Arg Lys Val Val Arg 
65                  70                  75                  80  


Leu Arg Gln Leu Asp Ala Thr Leu Glu Ser Leu Gly Phe Pro Ile Val 
                85                  90                  95      


Glu Pro Asp Ser Leu Asp Thr Trp Glu Ile Trp Leu Thr Arg Ala Lys 
            100                 105                 110         


Leu Ala Ser Ser Tyr Ile Gln Asp Asp Glu Thr Arg Lys Glu Asp Val 
        115                 120                 125             


Ser Ile Ala Leu Arg His Ile Ala Arg His Arg Gly Trp Arg Asn Pro 
    130                 135                 140                 


Tyr Ser Asn Val Glu Ser Leu Phe Val Asp Val Ala Pro Ser Glu Gln 
145                 150                 155                 160 


Tyr Glu Glu Leu Arg Arg Lys Ala Glu Glu Lys Leu Gly Thr Ser Leu 
                165                 170                 175     


Ser Gly Asn Pro Thr Ser Ala Glu Ile Val Glu Cys Ile Leu Lys Arg 
            180                 185                 190         


Gln Val Gly Glu Val Gln Leu Arg Thr Arg Ser Arg Lys Gly Val Asn 
        195                 200                 205             


Gly Asn Ala Val Glu Lys Glu Gly Leu Leu Pro Thr Lys Leu Met Gln 
    210                 215                 220                 


Ser Asp Asn Ala Ala Glu Ile Arg Arg Ile Phe Lys Val Gln Arg Ile 
225                 230                 235                 240 


Asp Asp Glu Thr Gly Arg Lys Leu Leu Arg Ala Val Phe Lys Ala Cys 
                245                 250                 255     


Ser Pro Lys Gly Ser Val Glu Arg Arg Val Gly Arg Asp Ala Leu Ala 
            260                 265                 270         


Pro Gly Leu Pro Arg Ala Leu Lys Ala Ser Leu Ala Phe Gln Glu Tyr 
        275                 280                 285             


Arg Ile Ala Asn Val Leu Thr Asn Leu Val Ile Ser Glu Asp Gly Thr 
    290                 295                 300                 


Lys Arg Lys Leu Thr Ile Ala Glu Lys Gln Arg Val Phe Gly Phe Leu 
305                 310                 315                 320 


Ser Ser Asn Glu Thr Asp Asp Ile Thr Trp Ile Asp Val Ala Glu Lys 
                325                 330                 335     


Leu Gly Leu Glu Arg Arg Gln Ile Gln Gly Val Gly Cys Leu Thr Ala 
            340                 345                 350         


Asp Gly Glu Glu Arg Ile Ser Ser Thr Pro Pro Arg Asn Ile Thr Ala 
        355                 360                 365             


Leu His Ile His Ser Ala Lys Pro Val Ile Arg Glu Lys Leu Val Ala 
    370                 375                 380                 


Trp Trp Lys Ala Ala Ser Pro Thr Val Arg Glu Thr Met Val Glu Leu 
385                 390                 395                 400 


Leu Ser Asn Thr Val Asp Ile Asp Arg Val Arg Glu Asp Met Asp Tyr 
                405                 410                 415     


Ser Ser Ala Val Ala Phe Ile Asp Ser Leu Gly Asp Glu Glu Leu Thr 
            420                 425                 430         


Ala Leu Asp Ser Val Asp Leu Leu Ser Gly Arg Ala Ala Tyr Ser Arg 
        435                 440                 445             


Gln Thr Leu Lys Gln Leu Thr Glu Arg Met Leu Asn Thr Asp Asp Asp 
    450                 455                 460                 


Leu His Glu Ala Arg Lys Ala Val Phe Gly Val Asp Asp Asn Trp Lys 
465                 470                 475                 480 


Pro Pro Val Asp Ala Ile Ser Thr Ser Val Gly Asn Pro Ala Val Asp 
                485                 490                 495     


Arg Val Leu Lys Ile Val Asn Arg Tyr Leu Leu Ala Cys Gln Lys Arg 
            500                 505                 510         


Trp Arg Asn Pro Gln Ser Val Gln Ile Glu His Val Arg Glu Ser Phe 
        515                 520                 525             


Ser Ser Val Ala Lys Ala Lys Glu Thr Glu Arg Val Gln Gly Glu Arg 
    530                 535                 540                 


Ala Arg Tyr Arg Asn Asp Leu Arg Arg Glu Leu Cys Glu Gln Glu Gly 
545                 550                 555                 560 


Leu Asn Lys Ile Arg Glu Ser Asp Ile Arg Arg Trp Glu Ser Val Gln 
                565                 570                 575     


Arg Gln Asn Gly Thr Cys Leu Tyr Cys Gly Ser Pro Ile Thr Phe Arg 
            580                 585                 590         


Thr Cys Glu Met Asp His Ile Val Pro Arg Lys Gly Val Gly Ser Thr 
        595                 600                 605             


Asn Thr Arg Val Asn Leu Ala Ala Ala Cys Ala Ala Cys Asn Lys Leu 
    610                 615                 620                 


Lys Ser Asn Thr Ala Phe Ser Val Trp Ala Arg Thr Glu Gly Ala Ala 
625                 630                 635                 640 


Asn Arg Lys Val Ser Gln Arg Asp Ala Ile Glu Arg Val Lys Thr Phe 
                645                 650                 655     


Ile Phe Asn Lys Ser Val Pro Pro Arg Glu Gln Arg Ala Phe Lys Gln 
            660                 665                 670         


Ala Val Ile Ser Arg Leu Arg Gln Ala Glu Ser Asp Pro Ala Ile Asp 
        675                 680                 685             


Asn Arg Ser Ile Glu Ser Val Ala Trp Met Ala Asp Glu Leu His Arg 
    690                 695                 700                 


Arg Ile Glu Ala Tyr Phe Asn Gln Asp Ala Asp Val Ser Gly Asn Thr 
705                 710                 715                 720 


Pro Ala Thr Gln Val Trp Val Phe Gln Gly Arg Val Thr Ala Leu Ala 
                725                 730                 735     


Arg Lys Ala Ser Gly Ile Glu Gly Arg Ile His Phe Ala Gly Glu Trp 
            740                 745                 750         


Lys Lys Thr Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ala Val 
        755                 760                 765             


Ile Ala Met Met Asn His Ser Ala Ala Gln Thr Leu Val Glu Arg Asp 
    770                 775                 780                 


Ser Leu Arg Leu Ser Gln Trp Ile Thr Arg Lys Pro Glu Thr Trp Lys 
785                 790                 795                 800 


Asn Tyr Pro Phe Ser Glu Gly Gln Lys Lys Thr Arg Phe Lys Glu Trp 
                805                 810                 815     


Leu Asp Cys Met Asn Ala Leu Leu Asp Leu Leu Asn Asp Ala Leu Asp 
            820                 825                 830         


Ser Asp Arg Val Pro Val Thr Arg Cys Gln Arg Met Ser Leu Gly Asn 
        835                 840                 845             


Ser Gln Ala His Ala Ala Thr Ile Arg Lys Met Lys Arg Val Glu Leu 
    850                 855                 860                 


Phe Ser Pro Met Asp Ala Asp Leu Ile Arg Arg Ala Ser Thr Pro Ala 
865                 870                 875                 880 


Leu Tyr Cys Ala Leu Thr Arg Leu Pro Glu Tyr Ser Pro Glu Lys Gly 
                885                 890                 895     


Leu Pro Glu Asn Arg Gly Arg Glu Ile Val Leu Asn Gly Arg His Ile 
            900                 905                 910         


Arg Ser Thr Glu Thr Val Asp Phe Phe Ala Ser Gly Ala Ala Gln Leu 
        915                 920                 925             


Met Val Arg Asn Gly Ser Ala Glu Ile Gly Asp Ser Ile His His Met 
    930                 935                 940                 


Arg Ile Tyr Arg Tyr Arg Lys Thr Gly Ala Lys Ser Gln Glu Tyr Val 
945                 950                 955                 960 


Tyr Gly Met Ile Arg Val Phe Gln Ile Asp Leu Leu His Ala Ser Ser 
                965                 970                 975     


Glu Asn Leu Phe Ala Val Gln Leu Pro Ser Gln Ser Val Ser Val Arg 
            980                 985                 990         


Tyr Gly Asp Lys Asn Val Val Gln  Ala Ile Gln Glu Gly  Arg Ala Glu 
        995                 1000                 1005             


Tyr Leu  Gly His Ile Val Pro  Asn Asp Glu Ile Leu  Ile Ser Tyr 
    1010                 1015                 1020             


Glu Gly  Val Arg Met Lys Asp  Ser Glu Lys Ile Gly  Ala Tyr Ala 
    1025                 1030                 1035             


Asn Asp  Phe Ser Gly Thr Ala  Ser Glu Leu Ala Gln  Arg Arg His 
    1040                 1045                 1050             


Trp Val  Val Val Gly Ser Asp  Val Ser Lys Leu Ala  Leu Arg Pro 
    1055                 1060                 1065             


Ser Tyr  Leu Ser Glu Glu Gly  Leu Glu Asn Ser Gly  Ser Glu Ser 
    1070                 1075                 1080             


Glu Arg  Leu Ser Lys Gln Thr  Arg Lys Val Ile Glu  Gly Lys Gly 
    1085                 1090                 1095             


Trp Val  Val Ala Val Asn Ile  Leu Ala Lys Tyr His  Pro Val Val 
    1100                 1105                 1110             


Ile Arg  Arg Asn Ala Leu Gly  Glu Pro Arg Phe Arg  Thr Asn Ser 
    1115                 1120                 1125             


Gly Met  Pro Val Ser Trp Arg  Trp Asp Arg 
    1130                 1135             


<210> 96
<211> 1187
<212> PRT
<213> Bifidobacterium longum

<400> 96
Met Leu Ser Arg Gln Leu Leu Gly Ala Ser His Leu Ala Arg Pro Val 
1               5                   10                  15      


Ser Tyr Ser Tyr Asn Val Gln Asp Asn Asp Val His Cys Ser Tyr Gly 
            20                  25                  30          


Glu Arg Cys Phe Met Arg Gly Lys Arg Tyr Arg Ile Gly Ile Asp Val 
        35                  40                  45              


Gly Leu Asn Ser Val Gly Leu Ala Ala Val Glu Val Ser Asp Glu Asn 
    50                  55                  60                  


Ser Pro Val Arg Leu Leu Asn Ala Gln Ser Val Ile His Asp Gly Gly 
65                  70                  75                  80  


Val Asp Pro Gln Lys Asn Lys Glu Ala Ile Thr Arg Lys Asn Met Ser 
                85                  90                  95      


Gly Val Ala Arg Arg Thr Arg Arg Met Arg Arg Arg Lys Arg Glu Arg 
            100                 105                 110         


Leu His Lys Leu Asp Met Leu Leu Gly Lys Phe Gly Tyr Pro Val Ile 
        115                 120                 125             


Glu Pro Glu Ser Leu Asp Lys Pro Phe Glu Glu Trp His Val Arg Ala 
    130                 135                 140                 


Glu Leu Ala Thr Arg Tyr Ile Glu Asp Asp Glu Leu Arg Arg Glu Ser 
145                 150                 155                 160 


Ile Ser Ile Ala Leu Arg His Met Ala Arg His Arg Gly Trp Arg Asn 
                165                 170                 175     


Pro Tyr Arg Gln Val Asp Ser Leu Ile Ser Asp Asn Pro Tyr Ser Lys 
            180                 185                 190         


Gln Tyr Gly Glu Leu Lys Glu Lys Ala Lys Ala Tyr Asn Asp Asp Ala 
        195                 200                 205             


Thr Ala Ala Glu Glu Glu Ser Thr Pro Ala Gln Leu Val Val Ala Met 
    210                 215                 220                 


Leu Asp Ala Gly Tyr Ala Glu Ala Pro Arg Leu Arg Trp Arg Thr Gly 
225                 230                 235                 240 


Ser Lys Lys Pro Asp Ala Glu Gly Tyr Leu Pro Val Arg Leu Met Gln 
                245                 250                 255     


Glu Asp Asn Ala Asn Glu Leu Lys Gln Ile Phe Arg Val Gln Arg Val 
            260                 265                 270         


Pro Ala Asp Glu Trp Lys Pro Leu Phe Arg Ser Val Phe Tyr Ala Val 
        275                 280                 285             


Ser Pro Lys Gly Ser Ala Glu Gln Arg Val Gly Gln Asp Pro Leu Ala 
    290                 295                 300                 


Pro Glu Gln Ala Arg Ala Leu Lys Ala Ser Leu Ala Phe Gln Glu Tyr 
305                 310                 315                 320 


Arg Ile Ala Asn Val Ile Thr Asn Leu Arg Ile Lys Asp Ala Ser Ala 
                325                 330                 335     


Glu Leu Arg Lys Leu Thr Val Asp Glu Lys Gln Ser Ile Tyr Asp Gln 
            340                 345                 350         


Leu Val Ser Pro Ser Ser Glu Asp Ile Thr Trp Ser Asp Leu Cys Asp 
        355                 360                 365             


Phe Leu Gly Phe Lys Arg Ser Gln Leu Lys Gly Val Gly Ser Leu Thr 
    370                 375                 380                 


Glu Asp Gly Glu Glu Arg Ile Ser Ser Arg Pro Pro Arg Leu Thr Ser 
385                 390                 395                 400 


Val Gln Arg Ile Tyr Glu Ser Asp Asn Lys Ile Arg Lys Pro Leu Val 
                405                 410                 415     


Ala Trp Trp Lys Ser Ala Ser Asp Asn Glu His Glu Ala Met Ile Arg 
            420                 425                 430         


Leu Leu Ser Asn Thr Val Asp Ile Asp Lys Val Arg Glu Asp Val Ala 
        435                 440                 445             


Tyr Ala Ser Ala Ile Glu Phe Ile Asp Gly Leu Asp Asp Asp Ala Leu 
    450                 455                 460                 


Thr Lys Leu Asp Ser Val Asp Leu Pro Ser Gly Arg Ala Ala Tyr Ser 
465                 470                 475                 480 


Val Glu Thr Leu Gln Lys Leu Thr Arg Gln Met Leu Thr Thr Asp Asp 
                485                 490                 495     


Asp Leu His Glu Ala Arg Lys Thr Leu Phe Asn Val Thr Asp Ser Trp 
            500                 505                 510         


Arg Pro Pro Ala Asp Pro Ile Gly Glu Pro Leu Gly Asn Pro Ser Val 
        515                 520                 525             


Asp Arg Val Leu Lys Asn Val Asn Arg Tyr Leu Met Asn Cys Gln Gln 
    530                 535                 540                 


Arg Trp Gly Asn Pro Val Ser Val Asn Ile Glu His Val Arg Ser Ser 
545                 550                 555                 560 


Phe Ser Ser Val Ala Phe Ala Arg Lys Asp Lys Arg Glu Tyr Glu Lys 
                565                 570                 575     


Asn Asn Glu Lys Arg Ser Ile Phe Arg Ser Ser Leu Ser Glu Gln Leu 
            580                 585                 590         


Arg Ala Asp Glu Gln Met Glu Lys Val Arg Glu Ser Asp Leu Arg Arg 
        595                 600                 605             


Leu Glu Ala Ile Gln Arg Gln Asn Gly Gln Cys Leu Tyr Cys Gly Arg 
    610                 615                 620                 


Thr Ile Thr Phe Arg Thr Cys Glu Met Asp His Ile Val Pro Arg Lys 
625                 630                 635                 640 


Gly Val Gly Ser Thr Asn Thr Arg Thr Asn Phe Ala Ala Val Cys Ala 
                645                 650                 655     


Glu Cys Asn Arg Met Lys Ser Asn Thr Pro Phe Ala Ile Trp Ala Arg 
            660                 665                 670         


Ser Glu Asp Ala Gln Thr Arg Gly Val Ser Leu Ala Glu Ala Lys Lys 
        675                 680                 685             


Arg Val Thr Met Phe Thr Phe Asn Pro Lys Ser Tyr Ala Pro Arg Glu 
    690                 695                 700                 


Val Lys Ala Phe Lys Gln Ala Val Ile Ala Arg Leu Gln Gln Thr Glu 
705                 710                 715                 720 


Asp Asp Ala Ala Ile Asp Asn Arg Ser Ile Glu Ser Val Ala Trp Met 
                725                 730                 735     


Ala Asp Glu Leu His Arg Arg Ile Asp Trp Tyr Phe Asn Ala Lys Gln 
            740                 745                 750         


Tyr Val Asn Ser Ala Ser Ile Asp Asp Ala Glu Ala Glu Thr Met Lys 
        755                 760                 765             


Thr Thr Val Ser Val Phe Gln Gly Arg Val Thr Ala Ser Ala Arg Arg 
    770                 775                 780                 


Ala Ala Gly Ile Glu Gly Lys Ile His Phe Ile Gly Gln Gln Ser Lys 
785                 790                 795                 800 


Thr Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ser Val Ile Ala 
                805                 810                 815     


Met Met Asn Thr Ala Ala Ala Gln Thr Leu Met Glu Arg Glu Ser Leu 
            820                 825                 830         


Arg Glu Ser Gln Arg Leu Ile Gly Leu Met Pro Gly Glu Arg Ser Trp 
        835                 840                 845             


Lys Glu Tyr Pro Tyr Glu Gly Thr Ser Arg Tyr Glu Ser Phe His Leu 
    850                 855                 860                 


Trp Leu Asp Asn Met Asp Val Leu Leu Glu Leu Leu Asn Asp Ala Leu 
865                 870                 875                 880 


Asp Asn Asp Arg Ile Ala Val Met Gln Ser Gln Arg Tyr Val Leu Gly 
                885                 890                 895     


Asn Ser Ile Ala His Asp Ala Thr Ile His Pro Leu Glu Lys Val Pro 
            900                 905                 910         


Leu Gly Ser Ala Met Ser Ala Asp Leu Ile Arg Arg Ala Ser Thr Pro 
        915                 920                 925             


Ala Leu Trp Cys Ala Leu Thr Arg Leu Pro Asp Tyr Asp Glu Lys Glu 
    930                 935                 940                 


Gly Leu Pro Glu Asp Ser His Arg Glu Ile Arg Val His Asp Thr Arg 
945                 950                 955                 960 


Tyr Ser Ala Asp Asp Glu Met Gly Phe Phe Ala Ser Gln Ala Ala Gln 
                965                 970                 975     


Ile Ala Val Gln Glu Gly Ser Ala Asp Ile Gly Ser Ala Ile His His 
            980                 985                 990         


Ala Arg Val Tyr Arg Cys Trp Lys  Thr Asn Ala Lys Gly  Val Arg Lys 
        995                 1000                 1005             


Tyr Phe  Tyr Gly Met Ile Arg  Val Phe Gln Thr Asp  Leu Leu Arg 
    1010                 1015                 1020             


Ala Cys  His Asp Asp Leu Phe  Thr Val Pro Leu Pro  Pro Gln Ser 
    1025                 1030                 1035             


Ile Ser  Met Arg Tyr Gly Glu  Pro Arg Val Val Gln  Ala Leu Gln 
    1040                 1045                 1050             


Ser Gly  Asn Ala Gln Tyr Leu  Gly Ser Leu Val Val  Gly Asp Glu 
    1055                 1060                 1065             


Ile Glu  Met Asp Phe Ser Ser  Leu Asp Val Asp Gly  Gln Ile Gly 
    1070                 1075                 1080             


Glu Tyr  Leu Gln Phe Phe Ser  Gln Phe Ser Gly Gly  Asn Leu Ala 
    1085                 1090                 1095             


Trp Lys  His Trp Val Val Asp  Gly Phe Phe Asn Gln  Thr Gln Leu 
    1100                 1105                 1110             


Arg Ile  Arg Pro Arg Tyr Leu  Ala Ala Glu Gly Leu  Ala Lys Ala 
    1115                 1120                 1125             


Phe Ser  Asp Asp Val Val Pro  Asp Gly Val Gln Lys  Ile Val Thr 
    1130                 1135                 1140             


Lys Gln  Gly Trp Leu Pro Pro  Val Asn Thr Ala Ser  Lys Thr Ala 
    1145                 1150                 1155             


Val Arg  Ile Val Arg Arg Asn  Ala Phe Gly Glu Pro  Arg Leu Ser 
    1160                 1165                 1170             


Ser Ala  His His Met Pro Cys  Ser Trp Gln Trp Arg  His Glu 
    1175                 1180                 1185         


<210> 97
<211> 1124
<212> PRT
<213> Bifidobacterium longum


<220>
<223> Bifidobacterium longum subsp. longum 2-2B

<400> 97
Leu Thr Gly His Ser Gly His Thr Phe Trp Pro Thr Ser Ser Ser Pro 
1               5                   10                  15      


Pro Ile Gln Leu Glu Gln Glu Lys Arg Pro Leu Pro Gln Arg Asn Thr 
            20                  25                  30          


Ser Gln Asn Gly His Thr Phe Trp Pro Ile Thr Arg Glu Arg Cys Phe 
        35                  40                  45              


Met Arg Gly Lys Arg Tyr Arg Ile Gly Ile Asp Val Gly Leu Asn Ser 
    50                  55                  60                  


Val Gly Leu Ala Ala Val Glu Val Ser Asp Glu Asn Ser Pro Val Arg 
65                  70                  75                  80  


Leu Leu Asn Ala Gln Ser Val Ile His Asp Gly Gly Val Asp Pro Gln 
                85                  90                  95      


Lys Asn Lys Glu Ala Ile Thr Arg Lys Asn Met Ser Gly Val Ala Arg 
            100                 105                 110         


Arg Thr Arg Arg Met Arg Arg Arg Lys Arg Glu Arg Leu His Lys Leu 
        115                 120                 125             


Asp Met Leu Leu Gly Lys Phe Gly Tyr Pro Val Ile Glu Pro Glu Ser 
    130                 135                 140                 


Leu Asp Lys Pro Phe Glu Glu Trp His Val Arg Ala Glu Leu Ala Thr 
145                 150                 155                 160 


Arg Tyr Ile Glu Asp Asp Glu Leu Arg Arg Glu Ser Ile Ser Ile Ala 
                165                 170                 175     


Leu Arg His Met Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Arg Gln 
            180                 185                 190         


Val Asp Ser Leu Ile Ser Asp Asn Pro Tyr Ser Lys Gln Tyr Gly Glu 
        195                 200                 205             


Leu Lys Glu Lys Ala Lys Ala Tyr Asn Asp Asp Ala Thr Ala Ala Glu 
    210                 215                 220                 


Glu Glu Ser Thr Pro Ala Gln Leu Val Val Ala Met Leu Asp Ala Gly 
225                 230                 235                 240 


Tyr Ala Glu Ala Pro Arg Leu Arg Trp Arg Thr Gly Ser Lys Lys Pro 
                245                 250                 255     


Asp Ala Glu Gly Tyr Leu Pro Val Arg Leu Met Gln Glu Asp Asn Ala 
            260                 265                 270         


Asn Glu Leu Lys Gln Ile Phe Arg Val Gln Arg Val Pro Ala Asp Glu 
        275                 280                 285             


Trp Lys Pro Leu Phe Arg Ser Val Phe Tyr Ala Val Ser Pro Lys Gly 
    290                 295                 300                 


Ser Ala Glu Gln Arg Val Gly Gln Asp Pro Leu Ala Pro Glu Gln Ala 
305                 310                 315                 320 


Arg Ala Leu Lys Ala Ser Leu Ala Phe Gln Glu Tyr Arg Ile Ala Asn 
                325                 330                 335     


Val Ile Thr Asn Leu Arg Ile Lys Asp Ala Ser Ala Glu Leu Arg Lys 
            340                 345                 350         


Leu Thr Val Asp Glu Lys Gln Ser Ile Tyr Asp Gln Leu Val Ser Pro 
        355                 360                 365             


Ser Ser Glu Asp Ile Thr Trp Ser Asp Leu Cys Asp Phe Leu Gly Phe 
    370                 375                 380                 


Lys Arg Ser Gln Leu Lys Gly Val Gly Ser Leu Thr Glu Asp Gly Glu 
385                 390                 395                 400 


Glu Arg Ile Ser Ser Arg Pro Pro Arg Leu Thr Ser Val Gln Arg Ile 
                405                 410                 415     


Tyr Glu Ser Asp Asn Lys Ile Arg Lys Pro Leu Val Ala Trp Trp Lys 
            420                 425                 430         


Ser Ala Ser Asp Asn Glu His Glu Ala Met Ile Arg Leu Leu Ser Asn 
        435                 440                 445             


Thr Val Asp Ile Asp Lys Val Arg Glu Asp Val Ala Tyr Ala Ser Ala 
    450                 455                 460                 


Ile Glu Phe Ile Asp Gly Leu Asp Asp Asp Ala Leu Thr Lys Leu Asp 
465                 470                 475                 480 


Ser Val Asp Leu Pro Ser Gly Arg Ala Ala Tyr Ser Val Glu Thr Leu 
                485                 490                 495     


Gln Lys Leu Thr Arg Gln Met Leu Thr Thr Asp Asp Asp Leu His Glu 
            500                 505                 510         


Ala Arg Lys Thr Leu Phe Asn Val Thr Asp Ser Trp Arg Pro Pro Ala 
        515                 520                 525             


Asp Pro Ile Gly Glu Pro Leu Gly Asn Pro Ser Val Asp Arg Val Leu 
    530                 535                 540                 


Lys Asn Val Asn Arg Tyr Leu Met Asn Cys Gln Gln Arg Trp Gly Asn 
545                 550                 555                 560 


Pro Val Ser Val Asn Ile Glu His Val Arg Ser Ser Phe Ser Ser Val 
                565                 570                 575     


Ala Phe Ala Arg Lys Asp Lys Arg Glu Tyr Glu Lys Asn Asn Glu Lys 
            580                 585                 590         


Arg Ser Ile Phe Arg Ser Ser Leu Ser Glu Gln Leu Arg Ala Asp Glu 
        595                 600                 605             


Gln Met Glu Lys Val Arg Glu Ser Asp Leu Arg Arg Leu Glu Ala Ile 
    610                 615                 620                 


Gln Arg Gln Asn Gly Gln Cys Leu Tyr Cys Gly Arg Thr Ile Thr Phe 
625                 630                 635                 640 


Arg Thr Cys Glu Met Asp His Ile Val Pro Arg Lys Gly Val Gly Ser 
                645                 650                 655     


Thr Asn Thr Arg Thr Asn Phe Ala Ala Val Cys Ala Glu Cys Asn Arg 
            660                 665                 670         


Met Lys Ser Asn Thr Pro Phe Ala Ile Trp Ala Arg Ser Glu Asp Ala 
        675                 680                 685             


Gln Thr Arg Gly Val Ser Leu Ala Glu Ala Lys Lys Arg Val Thr Met 
    690                 695                 700                 


Phe Thr Phe Asn Pro Lys Ser Tyr Ala Pro Arg Glu Val Lys Ala Phe 
705                 710                 715                 720 


Lys Gln Ala Val Ile Ala Arg Leu Gln Gln Thr Glu Asp Asp Ala Ala 
                725                 730                 735     


Ile Asp Asn Arg Ser Ile Glu Ser Val Ala Trp Met Ala Asp Glu Leu 
            740                 745                 750         


His Arg Arg Ile Asp Trp Tyr Phe Asn Ala Lys Gln Tyr Val Asn Ser 
        755                 760                 765             


Ala Ser Ile Asp Asp Ala Glu Ala Glu Thr Met Lys Thr Thr Val Ser 
    770                 775                 780                 


Val Phe Gln Gly Arg Val Thr Ala Ser Ala Arg Arg Ala Ala Gly Ile 
785                 790                 795                 800 


Glu Gly Lys Ile His Phe Ile Gly Gln Gln Ser Lys Thr Arg Leu Asp 
                805                 810                 815     


Arg Arg His His Ala Val Asp Ala Ser Val Ile Ala Met Met Asn Thr 
            820                 825                 830         


Ala Ala Ala Gln Thr Leu Met Glu Arg Glu Ser Leu Arg Glu Ser Gln 
        835                 840                 845             


Arg Leu Ile Gly Leu Met Pro Gly Glu Arg Ser Trp Lys Glu Tyr Pro 
    850                 855                 860                 


Tyr Glu Gly Thr Ser Arg Tyr Glu Ser Phe His Leu Trp Leu Asp Asn 
865                 870                 875                 880 


Met Asp Val Leu Leu Glu Leu Leu Asn Asp Ala Leu Asp Asn Asp Arg 
                885                 890                 895     


Ile Ala Val Met Gln Ser Gln Arg Tyr Val Leu Gly Asn Ser Ile Ala 
            900                 905                 910         


His Asp Ala Thr Ile His Pro Leu Glu Lys Val Pro Leu Gly Ser Ala 
        915                 920                 925             


Met Ser Ala Asp Leu Ile Arg Arg Ala Ser Thr Pro Ala Leu Trp Cys 
    930                 935                 940                 


Ala Leu Thr Arg Leu Pro Asp Tyr Asp Glu Lys Glu Gly Leu Pro Glu 
945                 950                 955                 960 


Asp Ser His Arg Glu Ile Arg Val His Asp Thr Arg Tyr Ser Ala Asp 
                965                 970                 975     


Asp Glu Met Gly Phe Phe Ala Ser Gln Ala Ala Gln Ile Ala Val Gln 
            980                 985                 990         


Glu Gly Ser Ala Asp Ile Gly Ser  Ala Ile His His Ala  Arg Val Tyr 
        995                 1000                 1005             


Arg Cys  Trp Lys Thr Asn Ala  Lys Gly Val Arg Lys  Tyr Phe Tyr 
    1010                 1015                 1020             


Gly Met  Ile Arg Val Phe Gln  Thr Asp Leu Leu Arg  Ala Cys His 
    1025                 1030                 1035             


Asp Asp  Leu Phe Thr Val Pro  Leu Pro Pro Gln Ser  Ile Ser Met 
    1040                 1045                 1050             


Arg Tyr  Gly Glu Pro Arg Val  Val Gln Ala Leu Gln  Ser Gly Asn 
    1055                 1060                 1065             


Ala Gln  Tyr Leu Gly Ser Leu  Val Val Gly Asp Glu  Ile Glu Met 
    1070                 1075                 1080             


Asp Phe  Pro Val Ser Met Leu  Met Val Arg Leu Ala  Ser Ile Tyr 
    1085                 1090                 1095             


Asn Ser  Ser Arg Ser Leu Val  Glu Gly Thr Leu His  Gly Asn Ile 
    1100                 1105                 1110             


Gly Leu  Leu Met Asp Ser Leu  Thr Arg Arg Ser 
    1115                 1120                 


<210> 98
<211> 1138
<212> PRT
<213> Bifidobacterium sp.

<400> 98
Met Asn Ser Val Gly Leu Ala Ala Val Glu Val Ser Asp Glu Asn Ser 
1               5                   10                  15      


Pro Val Arg Leu Leu Asn Ala Gln Ser Val Ile His Asp Gly Gly Val 
            20                  25                  30          


Asp Pro Gln Lys Asn Lys Glu Ala Ile Thr Arg Lys Asn Met Ser Gly 
        35                  40                  45              


Val Ala Arg Arg Thr Arg Arg Met Arg Arg Arg Lys Arg Glu Arg Leu 
    50                  55                  60                  


His Lys Leu Asp Met Leu Leu Gly Lys Phe Gly Tyr Pro Val Ile Glu 
65                  70                  75                  80  


Pro Glu Ser Leu Asp Lys Pro Phe Glu Glu Trp His Val Arg Ala Glu 
                85                  90                  95      


Leu Ala Thr Arg Tyr Ile Glu Asp Asp Glu Leu Arg Arg Glu Ser Ile 
            100                 105                 110         


Ser Ile Ala Leu Arg His Met Ala Arg His Arg Gly Trp Arg Asn Pro 
        115                 120                 125             


Tyr Arg Gln Val Asp Ser Leu Ile Ser Asp Asn Pro Tyr Ser Lys Gln 
    130                 135                 140                 


Tyr Gly Glu Leu Lys Glu Lys Ala Lys Ala Tyr Asn Asp Asp Ala Thr 
145                 150                 155                 160 


Ala Ala Glu Glu Glu Ser Thr Pro Ala Gln Leu Val Val Ala Met Leu 
                165                 170                 175     


Asp Ala Gly Tyr Ala Glu Ala Pro Arg Leu Arg Trp Arg Thr Gly Ser 
            180                 185                 190         


Lys Lys Pro Asp Ala Glu Gly Tyr Leu Pro Val Arg Leu Met Gln Glu 
        195                 200                 205             


Asp Asn Ala Asn Glu Leu Lys Gln Ile Phe Arg Val Gln Arg Val Pro 
    210                 215                 220                 


Ala Asp Glu Trp Lys Pro Leu Phe Arg Ser Val Phe Tyr Ala Val Ser 
225                 230                 235                 240 


Pro Lys Gly Ser Ala Glu Gln Arg Val Gly Gln Asp Pro Leu Ala Pro 
                245                 250                 255     


Glu Gln Ala Arg Ala Leu Lys Ala Ser Leu Ala Phe Gln Glu Tyr Arg 
            260                 265                 270         


Ile Ala Asn Val Ile Thr Asn Leu Arg Ile Lys Asp Ala Ser Ala Glu 
        275                 280                 285             


Leu Arg Lys Leu Thr Val Asp Glu Lys Gln Ser Ile Tyr Asp Gln Leu 
    290                 295                 300                 


Val Ser Pro Ser Ser Glu Asp Ile Thr Trp Ser Asp Leu Cys Asp Phe 
305                 310                 315                 320 


Leu Gly Phe Lys Arg Ser Gln Leu Lys Gly Val Gly Ser Leu Thr Glu 
                325                 330                 335     


Asp Gly Glu Glu Arg Ile Ser Ser Arg Pro Pro Arg Leu Thr Ser Val 
            340                 345                 350         


Gln Arg Ile Tyr Glu Ser Asp Asn Lys Ile Arg Lys Pro Leu Val Ala 
        355                 360                 365             


Trp Trp Lys Ser Ala Ser Asp Asn Glu His Glu Ala Met Ile Arg Leu 
    370                 375                 380                 


Leu Ser Asn Thr Val Asp Ile Asp Lys Val Arg Glu Asp Val Ala Tyr 
385                 390                 395                 400 


Ala Ser Ala Ile Glu Phe Ile Asp Gly Leu Asp Asp Asp Ala Leu Thr 
                405                 410                 415     


Lys Leu Asp Ser Val Asp Leu Pro Ser Gly Arg Ala Ala Tyr Ser Val 
            420                 425                 430         


Glu Thr Leu Gln Lys Leu Thr Arg Gln Met Leu Thr Thr Asp Asp Asp 
        435                 440                 445             


Leu His Glu Ala Arg Lys Thr Leu Phe Asn Val Thr Asp Ser Trp Arg 
    450                 455                 460                 


Pro Pro Ala Asp Pro Ile Gly Glu Pro Leu Gly Asn Pro Ser Val Asp 
465                 470                 475                 480 


Arg Val Leu Lys Asn Val Asn Arg Tyr Leu Met Asn Cys Gln Gln Arg 
                485                 490                 495     


Trp Gly Asn Pro Val Ser Val Asn Ile Glu His Val Arg Ser Ser Phe 
            500                 505                 510         


Ser Ser Val Ala Phe Ala Arg Lys Asp Lys Arg Glu Tyr Glu Lys Asn 
        515                 520                 525             


Asn Glu Lys Arg Ser Ile Phe Arg Ser Ser Leu Ser Glu Gln Leu Arg 
    530                 535                 540                 


Ala Asp Glu Gln Met Glu Lys Val Arg Glu Ser Asp Leu Arg Arg Leu 
545                 550                 555                 560 


Glu Ala Ile Gln Arg Gln Asn Gly Gln Cys Leu Tyr Cys Gly Arg Thr 
                565                 570                 575     


Ile Thr Phe Arg Thr Cys Glu Met Asp His Ile Val Pro Arg Lys Gly 
            580                 585                 590         


Val Gly Ser Thr Asn Thr Arg Thr Asn Phe Ala Ala Val Cys Ala Glu 
        595                 600                 605             


Cys Asn Arg Met Lys Ser Asn Thr Pro Phe Ala Ile Trp Ala Arg Ser 
    610                 615                 620                 


Glu Asp Ala Gln Thr Arg Gly Val Ser Leu Ala Glu Ala Lys Lys Arg 
625                 630                 635                 640 


Val Thr Met Phe Thr Phe Asn Pro Lys Ser Tyr Ala Pro Arg Glu Val 
                645                 650                 655     


Lys Ala Phe Lys Gln Ala Val Ile Ala Arg Leu Gln Gln Thr Glu Asp 
            660                 665                 670         


Asp Ala Ala Ile Asp Asn Arg Ser Ile Glu Ser Val Ala Trp Met Ala 
        675                 680                 685             


Asp Glu Leu His Arg Arg Ile Asp Trp Tyr Phe Asn Ala Lys Gln Tyr 
    690                 695                 700                 


Val Asn Ser Ala Ser Ile Asp Asp Ala Glu Ala Glu Thr Met Lys Thr 
705                 710                 715                 720 


Thr Val Ser Val Phe Gln Gly Arg Val Thr Ala Ser Ala Arg Arg Ala 
                725                 730                 735     


Ala Gly Ile Glu Gly Lys Ile His Phe Ile Gly Gln Gln Ser Lys Thr 
            740                 745                 750         


Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ser Val Ile Ala Met 
        755                 760                 765             


Met Asn Thr Ala Ala Ala Gln Thr Leu Met Glu Arg Glu Ser Leu Arg 
    770                 775                 780                 


Glu Ser Gln Arg Leu Ile Gly Leu Met Pro Gly Glu Arg Ser Trp Lys 
785                 790                 795                 800 


Glu Tyr Pro Tyr Glu Gly Thr Ser Arg Tyr Glu Ser Phe His Leu Trp 
                805                 810                 815     


Leu Asp Asn Met Asp Val Leu Leu Glu Leu Leu Asn Asp Ala Leu Asp 
            820                 825                 830         


Asn Asp Arg Ile Ala Val Met Gln Ser Gln Arg Tyr Val Leu Gly Asn 
        835                 840                 845             


Ser Ile Ala His Asp Ala Thr Ile His Pro Leu Glu Lys Val Pro Leu 
    850                 855                 860                 


Gly Ser Ala Met Ser Ala Asp Leu Ile Arg Arg Ala Ser Thr Pro Ala 
865                 870                 875                 880 


Leu Trp Cys Ala Leu Thr Arg Leu Pro Asp Tyr Asp Glu Lys Glu Gly 
                885                 890                 895     


Leu Pro Glu Asp Ser His Arg Glu Ile Arg Val His Asp Thr Arg Tyr 
            900                 905                 910         


Ser Ala Asp Asp Glu Met Gly Phe Phe Ala Ser Gln Ala Ala Gln Ile 
        915                 920                 925             


Ala Val Gln Glu Gly Ser Ala Asp Ile Gly Ser Ala Ile His His Ala 
    930                 935                 940                 


Arg Val Tyr Arg Cys Trp Lys Thr Asn Ala Lys Gly Val Arg Lys Tyr 
945                 950                 955                 960 


Phe Tyr Gly Met Ile Arg Val Phe Gln Thr Asp Leu Leu Arg Ala Cys 
                965                 970                 975     


His Asp Asp Leu Phe Thr Val Pro Leu Pro Pro Gln Ser Ile Ser Met 
            980                 985                 990         


Arg Tyr Gly Glu Pro Arg Val Val  Gln Ala Leu Gln Ser  Gly Asn Ala 
        995                 1000                 1005             


Gln Tyr  Leu Gly Ser Leu Val  Val Gly Asp Glu Ile  Glu Met Asp 
    1010                 1015                 1020             


Phe Ser  Ser Leu Asp Val Asp  Gly Gln Ile Gly Glu  Tyr Leu Gln 
    1025                 1030                 1035             


Phe Phe  Ser Gln Phe Ser Gly  Gly Asn Leu Ala Trp  Lys His Trp 
    1040                 1045                 1050             


Val Val  Asp Gly Phe Phe Asn  Gln Thr Gln Leu Arg  Ile Arg Pro 
    1055                 1060                 1065             


Arg Tyr  Leu Ala Ala Glu Gly  Leu Ala Lys Ala Phe  Ser Asp Asp 
    1070                 1075                 1080             


Val Val  Pro Asp Gly Val Gln  Lys Ile Val Thr Lys  Gln Gly Trp 
    1085                 1090                 1095             


Leu Pro  Pro Val Asn Thr Ala  Ser Lys Thr Ala Val  Arg Ile Val 
    1100                 1105                 1110             


Arg Arg  Asn Ala Phe Gly Glu  Pro Arg Leu Ser Ser  Ala His His 
    1115                 1120                 1125             


Met Pro  Cys Ser Trp Gln Trp  Arg His Glu 
    1130                 1135             


<210> 99
<211> 1151
<212> PRT
<213> Bifidobacterium sp.


<220>
<223> Bifidobacterium sp. 12_1_47BFAA

<400> 99
Met Arg Gly Lys Arg Tyr Arg Ile Gly Ile Asp Val Gly Leu Asn Ser 
1               5                   10                  15      


Val Gly Leu Ala Ala Val Glu Val Ser Asp Glu Asn Ser Pro Val Arg 
            20                  25                  30          


Leu Leu Asn Ala Gln Ser Val Ile His Asp Gly Gly Val Asp Pro Gln 
        35                  40                  45              


Lys Asn Lys Glu Ala Ile Thr Arg Lys Asn Met Ser Gly Val Ala Arg 
    50                  55                  60                  


Arg Thr Arg Arg Met Arg Arg Arg Lys Arg Glu Arg Leu His Lys Leu 
65                  70                  75                  80  


Asp Met Leu Leu Gly Lys Phe Gly Tyr Pro Val Ile Glu Pro Glu Ser 
                85                  90                  95      


Leu Asp Lys Pro Phe Glu Glu Trp His Val Arg Ala Glu Leu Ala Thr 
            100                 105                 110         


Arg Tyr Ile Glu Asp Asp Glu Leu Arg Arg Glu Ser Ile Ser Ile Ala 
        115                 120                 125             


Leu Arg His Met Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Arg Gln 
    130                 135                 140                 


Val Asp Ser Leu Ile Ser Asp Asn Pro Tyr Ser Lys Gln Tyr Gly Glu 
145                 150                 155                 160 


Leu Lys Glu Lys Ala Lys Ala Tyr Asn Asp Asp Ala Thr Ala Ala Glu 
                165                 170                 175     


Glu Glu Ser Thr Pro Ala Gln Leu Val Val Ala Met Leu Asp Ala Gly 
            180                 185                 190         


Tyr Ala Glu Ala Pro Arg Leu Arg Trp Arg Thr Gly Ser Lys Lys Pro 
        195                 200                 205             


Asp Ala Glu Gly Tyr Leu Pro Val Arg Leu Met Gln Glu Asp Asn Ala 
    210                 215                 220                 


Asn Glu Leu Lys Gln Ile Phe Arg Val Gln Arg Val Pro Ala Asp Glu 
225                 230                 235                 240 


Trp Lys Pro Leu Phe Arg Ser Val Phe Tyr Ala Val Ser Pro Lys Gly 
                245                 250                 255     


Ser Ala Glu Gln Arg Val Gly Gln Asp Pro Leu Ala Pro Glu Gln Ala 
            260                 265                 270         


Arg Ala Leu Lys Ala Ser Leu Ala Phe Gln Glu Tyr Arg Ile Ala Asn 
        275                 280                 285             


Val Ile Thr Asn Leu Arg Ile Lys Asp Ala Ser Ala Glu Leu Arg Lys 
    290                 295                 300                 


Leu Thr Val Asp Glu Lys Gln Ser Ile Tyr Asp Gln Leu Val Ser Pro 
305                 310                 315                 320 


Ser Ser Glu Asp Ile Thr Trp Ser Asp Leu Cys Asp Phe Leu Gly Phe 
                325                 330                 335     


Lys Arg Ser Gln Leu Lys Gly Val Gly Ser Leu Thr Glu Asp Gly Glu 
            340                 345                 350         


Glu Arg Ile Ser Ser Arg Pro Pro Arg Leu Thr Ser Val Gln Arg Ile 
        355                 360                 365             


Tyr Glu Ser Asp Asn Lys Ile Arg Lys Pro Leu Val Ala Trp Trp Lys 
    370                 375                 380                 


Ser Ala Ser Asp Asn Glu His Glu Ala Met Ile Arg Leu Leu Ser Asn 
385                 390                 395                 400 


Thr Val Asp Ile Asp Lys Val Arg Glu Asp Val Ala Tyr Ala Ser Ala 
                405                 410                 415     


Ile Glu Phe Ile Asp Gly Leu Asp Asp Asp Ala Leu Thr Lys Leu Asp 
            420                 425                 430         


Ser Val Asp Leu Pro Ser Gly Arg Ala Ala Tyr Ser Val Glu Thr Leu 
        435                 440                 445             


Gln Lys Leu Thr Arg Gln Met Leu Thr Thr Asp Asp Asp Leu His Glu 
    450                 455                 460                 


Ala Arg Lys Thr Leu Phe Asn Val Thr Asp Ser Trp Arg Pro Pro Ala 
465                 470                 475                 480 


Asp Pro Ile Gly Glu Pro Leu Gly Asn Pro Ser Val Asp Arg Val Leu 
                485                 490                 495     


Lys Asn Val Asn Arg Tyr Leu Met Asn Cys Gln Gln Arg Trp Gly Asn 
            500                 505                 510         


Pro Val Ser Val Asn Ile Glu His Val Arg Ser Ser Phe Ser Ser Val 
        515                 520                 525             


Ala Phe Ala Arg Lys Asp Lys Arg Glu Tyr Glu Lys Asn Asn Glu Lys 
    530                 535                 540                 


Arg Ser Ile Phe Arg Ser Ser Leu Ser Glu Gln Leu Arg Ala Asp Glu 
545                 550                 555                 560 


Gln Met Glu Lys Val Arg Glu Ser Asp Leu Arg Arg Leu Glu Ala Ile 
                565                 570                 575     


Gln Arg Gln Asn Gly Gln Cys Leu Tyr Cys Gly Arg Thr Ile Thr Phe 
            580                 585                 590         


Arg Thr Cys Glu Met Asp His Ile Val Pro Arg Lys Gly Val Gly Ser 
        595                 600                 605             


Thr Asn Thr Arg Thr Asn Phe Ala Ala Val Cys Ala Glu Cys Asn Arg 
    610                 615                 620                 


Met Lys Ser Asn Thr Pro Phe Ala Ile Trp Ala Arg Ser Glu Asp Ala 
625                 630                 635                 640 


Gln Thr Arg Gly Val Ser Leu Ala Glu Ala Lys Lys Arg Val Thr Met 
                645                 650                 655     


Phe Thr Phe Asn Pro Lys Ser Tyr Ala Pro Arg Glu Val Lys Ala Phe 
            660                 665                 670         


Lys Gln Ala Val Ile Ala Arg Leu Gln Gln Thr Glu Asp Asp Ala Ala 
        675                 680                 685             


Ile Asp Asn Arg Ser Ile Glu Ser Val Ala Trp Met Ala Asp Glu Leu 
    690                 695                 700                 


His Arg Arg Ile Asp Trp Tyr Phe Asn Ala Lys Gln Tyr Val Asn Ser 
705                 710                 715                 720 


Ala Ser Ile Asp Asp Ala Glu Ala Glu Thr Met Lys Thr Thr Val Ser 
                725                 730                 735     


Val Phe Gln Gly Arg Val Thr Ala Ser Ala Arg Arg Ala Ala Gly Ile 
            740                 745                 750         


Glu Gly Lys Ile His Phe Ile Gly Gln Gln Ser Lys Thr Arg Leu Asp 
        755                 760                 765             


Arg Arg His His Ala Val Asp Ala Ser Val Ile Ala Met Met Asn Thr 
    770                 775                 780                 


Ala Ala Ala Gln Thr Leu Met Glu Arg Glu Ser Leu Arg Glu Ser Gln 
785                 790                 795                 800 


Arg Leu Ile Gly Leu Met Pro Gly Glu Arg Ser Trp Lys Glu Tyr Pro 
                805                 810                 815     


Tyr Glu Gly Thr Ser Arg Tyr Glu Ser Phe His Leu Trp Leu Asp Asn 
            820                 825                 830         


Met Asp Val Leu Leu Glu Leu Leu Asn Asp Ala Leu Asp Asn Asp Arg 
        835                 840                 845             


Ile Ala Val Met Gln Ser Gln Arg Tyr Val Leu Gly Asn Ser Ile Ala 
    850                 855                 860                 


His Asp Ala Thr Ile His Pro Leu Glu Lys Val Pro Leu Gly Ser Ala 
865                 870                 875                 880 


Met Ser Ala Asp Leu Ile Arg Arg Ala Ser Thr Pro Ala Leu Trp Cys 
                885                 890                 895     


Ala Leu Thr Arg Leu Pro Asp Tyr Asp Glu Lys Glu Gly Leu Pro Glu 
            900                 905                 910         


Asp Ser His Arg Glu Ile Arg Val His Asp Thr Arg Tyr Ser Ala Asp 
        915                 920                 925             


Asp Glu Met Gly Phe Phe Ala Ser Gln Ala Ala Gln Ile Ala Val Gln 
    930                 935                 940                 


Glu Gly Ser Ala Asp Ile Gly Ser Ala Ile His His Ala Arg Val Tyr 
945                 950                 955                 960 


Arg Cys Trp Lys Thr Asn Ala Lys Gly Val Arg Lys Tyr Phe Tyr Gly 
                965                 970                 975     


Met Ile Arg Val Phe Gln Thr Asp Leu Leu Arg Ala Cys His Asp Asp 
            980                 985                 990         


Leu Phe Thr Val Pro Leu Pro Pro  Gln Ser Ile Ser Met  Arg Tyr Gly 
        995                 1000                 1005             


Glu Pro  Arg Val Val Gln Ala  Leu Gln Ser Gly Asn  Ala Gln Tyr 
    1010                 1015                 1020             


Leu Gly  Ser Leu Val Val Gly  Asp Glu Ile Glu Met  Asp Phe Ser 
    1025                 1030                 1035             


Ser Leu  Asp Val Asp Gly Gln  Ile Gly Glu Tyr Leu  Gln Phe Phe 
    1040                 1045                 1050             


Ser Gln  Phe Ser Gly Gly Asn  Leu Ala Trp Lys His  Trp Val Val 
    1055                 1060                 1065             


Asp Gly  Phe Phe Asn Gln Thr  Gln Leu Arg Ile Arg  Pro Arg Tyr 
    1070                 1075                 1080             


Leu Ala  Ala Glu Gly Leu Ala  Lys Ala Phe Ser Asp  Asp Val Val 
    1085                 1090                 1095             


Pro Asp  Gly Val Gln Lys Ile  Val Thr Lys Gln Gly  Trp Leu Pro 
    1100                 1105                 1110             


Pro Val  Asn Thr Ala Ser Lys  Thr Ala Val Arg Ile  Val Arg Arg 
    1115                 1120                 1125             


Asn Ala  Phe Gly Glu Pro Arg  Leu Ser Ser Ala His  His Met Pro 
    1130                 1135                 1140             


Cys Ser  Trp Gln Trp Arg His  Glu 
    1145                 1150     


<210> 100
<211> 1092
<212> PRT
<213> Brevibacillus laterosporus


<220>
<223> Brevibacillus laterosporus GI-9

<400> 100
Met Ala Tyr Thr Met Gly Ile Asp Val Gly Ile Ala Ser Cys Gly Trp 
1               5                   10                  15      


Ala Ile Val Asp Leu Glu Arg Gln Arg Ile Ile Asp Ile Gly Val Arg 
            20                  25                  30          


Thr Phe Glu Lys Ala Glu Asn Pro Lys Asn Gly Glu Ala Leu Ala Val 
        35                  40                  45              


Pro Arg Arg Glu Ala Arg Ser Ser Arg Arg Arg Leu Arg Arg Lys Lys 
    50                  55                  60                  


His Arg Ile Glu Arg Leu Lys Tyr Met Phe Val Arg Asn Gly Leu Ala 
65                  70                  75                  80  


Val Asp Ile Gln His Leu Glu Gln Thr Leu Arg Ser Gln Asn Glu Ile 
                85                  90                  95      


Asp Val Trp Gln Leu Arg Val Asp Gly Leu Asp Arg Met Leu Thr Gln 
            100                 105                 110         


Lys Glu Trp Leu Arg Val Leu Ile His Leu Ala Gln Arg Arg Gly Phe 
        115                 120                 125             


Gln Ser Asn Arg Lys Thr Asp Gly Ser Ser Glu Asp Gly Gln Val Leu 
    130                 135                 140                 


Val Asn Val Thr Glu Asn Asp Arg Leu Met Glu Glu Lys Asp Tyr Arg 
145                 150                 155                 160 


Thr Val Ala Glu Met Met Val Lys Asp Glu Lys Phe Ser Asp His Lys 
                165                 170                 175     


Arg Asn Lys Asn Gly Asn Tyr His Gly Val Val Ser Arg Ala Ser Leu 
            180                 185                 190         


Leu Val Glu Ile His Thr Leu Phe Glu Ser Gln Arg Gln His His Asn 
        195                 200                 205             


Phe Leu Ala Ser Lys Asp Phe Glu Leu Glu Tyr Ile Asn Ile Trp Ser 
    210                 215                 220                 


Ser Gln Arg Pro Val Ala Thr Lys Asp Gln Ile Glu Lys Met Ile Gly 
225                 230                 235                 240 


Thr Cys Thr Phe Leu Pro Lys Glu Lys Arg Ala Pro Lys Ala Ser Trp 
                245                 250                 255     


His Phe Gln Tyr Phe Met Leu Leu Gln Thr Ile Asn His Ile Arg Ile 
            260                 265                 270         


Thr Asn Ala Gln Gly Thr Arg Pro Leu Asn Lys Glu Glu Ile Glu Gln 
        275                 280                 285             


Val Val Asn Met Ala Leu Thr Lys Ser Lys Val Ser Tyr His Asp Ile 
    290                 295                 300                 


Arg Lys Val Leu Asp Leu Ser Glu Glu Tyr Gln Phe Val Gly Leu Asp 
305                 310                 315                 320 


Tyr Gly Lys Glu Asp Glu Lys Lys Lys Val Glu Ser Lys Glu Thr Ile 
                325                 330                 335     


Ile Lys Leu Asp Asp Tyr His Lys Leu Asn Lys Ile Phe Asn Glu Val 
            340                 345                 350         


Glu Leu Ala Lys Gly Glu Thr Trp Glu Ala Val Asp Tyr Asp Thr Val 
        355                 360                 365             


Ala Tyr Ala Leu Thr Phe Phe Lys Asp Asp Glu Asp Ile Arg Asp Tyr 
    370                 375                 380                 


Leu Gln Asn Lys Tyr Lys Asp Ser Lys Asn Arg Leu Val Lys Asn Val 
385                 390                 395                 400 


Ala Asn Lys Glu Tyr Thr Asn Glu Leu Ile Glu Lys Val Ser Thr Leu 
                405                 410                 415     


Ser Phe Arg Lys Val Gly His Leu Ser Leu Lys Ala Leu Arg Lys Ile 
            420                 425                 430         


Ile Pro Phe Leu Glu Gln Gly Met Thr Tyr Asp Lys Ala Cys Gln Ala 
        435                 440                 445             


Ala Gly Phe Asn Phe Gln Gly Ile Ser Lys Lys Lys Arg Ser Val Val 
    450                 455                 460                 


Leu Pro Val Ile Asp Gln Ile Ser Asn Pro Val Val Asn Arg Ala Leu 
465                 470                 475                 480 


Thr Gln Thr Arg Lys Val Ile Asn Ala Leu Ile Lys Lys Tyr Gly Ser 
                485                 490                 495     


Pro Glu Thr Ile His Ile Glu Thr Ala Arg Glu Leu Ser Lys Arg Phe 
            500                 505                 510         


Asp Glu Arg Lys Asn Ile Thr Lys Asp Tyr Lys Glu Asn Arg Asp Lys 
        515                 520                 525             


Asn Glu Arg Ala Lys Lys His Leu Ser Glu Leu Gly Ile Ile Asn Pro 
    530                 535                 540                 


Thr Gly Leu Asp Ile Val Lys Tyr Lys Leu Trp Cys Glu Gln Gln Gly 
545                 550                 555                 560 


Arg Cys Met Tyr Ser Asn Gln Pro Ile Ser Phe Glu Arg Leu Arg Glu 
                565                 570                 575     


Ser Gly Tyr Thr Glu Val Asp His Ile Ile Pro Tyr Ser Arg Ser Met 
            580                 585                 590         


Asn Asp Ser Tyr Asn Asn Arg Val Leu Val Met Thr Arg Glu Asn Arg 
        595                 600                 605             


Glu Lys Ser Asn Gln Thr Pro Tyr Glu Tyr Met Gly Asn Asp Thr Gln 
    610                 615                 620                 


Arg Trp Asp Glu Phe Glu Gln Arg Val Thr Thr Asn Pro Gln Ile Lys 
625                 630                 635                 640 


Lys Glu Lys Arg Gln Asn Leu Leu Leu Lys Gly Phe Thr Asn Arg Arg 
                645                 650                 655     


Glu Leu Glu Met Leu Glu Arg Asn Leu Asn Asp Thr Arg His Ile Thr 
            660                 665                 670         


Lys Tyr Leu Ser His Phe Ile Ser Thr Asn Leu Glu Phe Ser Pro Ser 
        675                 680                 685             


Asp Lys Lys Lys Lys Val Val Asn Thr Ser Gly Arg Ile Thr Ser His 
    690                 695                 700                 


Leu Arg Ser Arg Trp Gly Leu Glu Lys Asn Arg Glu Gln Asn Asp Leu 
705                 710                 715                 720 


His His Ala Met Asp Ala Val Val Ile Ala Val Thr Ser Asp Ser Phe 
                725                 730                 735     


Ile Gln Gln Val Thr Asn Tyr Tyr Lys Arg Lys Glu Arg Arg Glu Leu 
            740                 745                 750         


Asn Gly Asp Asp Lys Phe Pro Leu Pro Trp Lys Phe Phe Arg Glu Glu 
        755                 760                 765             


Val Ile Ala Arg Leu Ser Pro Asn Pro Lys Glu Gln Ile Glu Ala Leu 
    770                 775                 780                 


Pro Asn His Phe Tyr Ser Glu Asp Glu Leu Ala Asp Leu Gln Pro Ile 
785                 790                 795                 800 


Phe Val Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Glu Ala His Gln 
                805                 810                 815     


Ala Gln Phe Arg Arg Val Val Gly Lys Thr Lys Glu Gly Lys Asn Ile 
            820                 825                 830         


Thr Ala Lys Lys Thr Ala Leu Val Asp Ile Ser Tyr Asp Lys Asn Gly 
        835                 840                 845             


Asp Phe Asn Met Tyr Gly Arg Glu Thr Asp Pro Ala Thr Tyr Glu Ala 
    850                 855                 860                 


Ile Lys Glu Arg Tyr Leu Glu Phe Gly Gly Asn Ala Lys Lys Ala Phe 
865                 870                 875                 880 


Ser Thr Asp Leu His Lys Pro Lys Lys Asp Gly Thr Lys Gly Pro Leu 
                885                 890                 895     


Ile Lys Ser Val Arg Ile Met Glu Asn Lys Thr Leu Val His Pro Val 
            900                 905                 910         


Asn Lys Gly Lys Gly Val Val Tyr Asn Ser Ser Ile Val Arg Thr Asp 
        915                 920                 925             


Val Phe Gln Arg Lys Glu Lys Tyr Tyr Leu Leu Pro Val Tyr Val Thr 
    930                 935                 940                 


Asp Val Thr Lys Gly Lys Leu Pro Asn Lys Val Ile Ala Ala Lys Lys 
945                 950                 955                 960 


Gly Tyr Asp Asp Trp Ile Glu Val Asp Asp Ser Phe Thr Phe Leu Tyr 
                965                 970                 975     


Ser Leu Tyr Pro Asn Asp Leu Ile Phe Ile Arg Gln Asn Pro Lys Lys 
            980                 985                 990         


Lys Ile Ser Leu Lys Lys Arg Ile  Glu Ser His Ser Ile  Ser Asp Ser 
        995                 1000                 1005             


Lys Glu  Val Gln Glu Ile Leu  Thr Tyr Tyr Lys Gly  Val Asp Ser 
    1010                 1015                 1020             


Ser Thr  Ala Ala Ile Glu Phe  Ile Thr His Asp Gly  Ser Tyr Tyr 
    1025                 1030                 1035             


Ala Lys  Gly Val Gly Val Gln  Asn Leu Asp Cys Phe  Glu Lys Tyr 
    1040                 1045                 1050             


Gln Val  Asp Ile Leu Gly Asn  Tyr Ser Lys Val Lys  Gly Glu Lys 
    1055                 1060                 1065             


Arg Leu  Glu Leu Glu Thr Ser  Asp Asn Asn His Lys  Gly Lys Asp 
    1070                 1075                 1080             


Val Asn  Ser Ile Lys Ser Thr  Ser Arg 
    1085                 1090         


<210> 101
<211> 1428
<212> PRT
<213> Burkholderiales bacterium


<220>
<223> Burkholderiales bacterium 1_1_47

<400> 101
Met Gly Lys Thr His Ile Ile Gly Val Gly Leu Asp Leu Gly Gly Thr 
1               5                   10                  15      


Tyr Thr Gly Thr Phe Ile Thr Ser His Pro Ser Asp Glu Ala Glu His 
            20                  25                  30          


Arg Asp His Ser Ser Ala Phe Thr Val Val Asn Ser Glu Lys Leu Ser 
        35                  40                  45              


Phe Ser Ser Lys Ser Arg Thr Ala Val Arg His Arg Val Arg Ser Tyr 
    50                  55                  60                  


Lys Gly Phe Asp Leu Arg Arg Arg Leu Leu Leu Leu Val Ala Glu Tyr 
65                  70                  75                  80  


Gln Leu Leu Gln Lys Lys Gln Thr Leu Ala Pro Glu Glu Arg Glu Asn 
                85                  90                  95      


Leu Arg Ile Ala Leu Ser Gly Tyr Leu Lys Arg Lys Gly Tyr Ala Arg 
            100                 105                 110         


Thr Glu Ala Glu Thr Asp Thr Ser Val Leu Glu Ser Leu Asp Pro Ser 
        115                 120                 125             


Val Phe Ser Ser Ala Pro Ser Phe Thr Asn Phe Phe Asn Asp Ser Glu 
    130                 135                 140                 


Pro Leu Asn Ile Gln Trp Glu Ala Ile Ala Asn Ser Pro Glu Thr Thr 
145                 150                 155                 160 


Lys Ala Leu Asn Lys Glu Leu Ser Gly Gln Lys Glu Ala Asp Phe Lys 
                165                 170                 175     


Lys Tyr Ile Lys Thr Ser Phe Pro Glu Tyr Ser Ala Lys Glu Ile Leu 
            180                 185                 190         


Ala Asn Tyr Val Glu Gly Arg Arg Ala Ile Leu Asp Ala Ser Lys Tyr 
        195                 200                 205             


Ile Ala Asn Leu Gln Ser Leu Gly His Lys His Arg Ser Lys Tyr Leu 
    210                 215                 220                 


Ser Asp Ile Leu Gln Asp Met Lys Arg Asp Ser Arg Ile Thr Arg Leu 
225                 230                 235                 240 


Ser Glu Ala Phe Gly Ser Thr Asp Asn Leu Trp Arg Ile Ile Gly Asn 
                245                 250                 255     


Ile Ser Asn Leu Gln Glu Arg Ala Val Arg Trp Tyr Phe Asn Asp Ala 
            260                 265                 270         


Lys Phe Glu Gln Gly Gln Glu Gln Leu Asp Ala Val Lys Leu Lys Asn 
        275                 280                 285             


Val Leu Val Arg Ala Leu Lys Tyr Leu Arg Ser Asp Asp Lys Glu Trp 
    290                 295                 300                 


Ser Ala Ser Gln Lys Gln Ile Ile Gln Ser Leu Glu Gln Ser Gly Asp 
305                 310                 315                 320 


Val Leu Asp Val Leu Ala Gly Leu Asp Pro Asp Arg Thr Ile Pro Pro 
                325                 330                 335     


Tyr Glu Asp Gln Asn Asn Arg Arg Pro Pro Glu Asp Gln Thr Leu Tyr 
            340                 345                 350         


Leu Asn Pro Lys Ala Leu Ser Ser Glu Tyr Gly Glu Lys Trp Lys Ser 
        355                 360                 365             


Trp Ala Asn Lys Phe Ala Gly Ala Tyr Pro Leu Leu Thr Glu Asp Leu 
    370                 375                 380                 


Thr Glu Ile Leu Lys Asn Thr Asp Arg Lys Ser Arg Ile Lys Ile Arg 
385                 390                 395                 400 


Ser Asp Val Leu Pro Asp Ser Asp Tyr Arg Leu Ala Tyr Ile Leu Gln 
                405                 410                 415     


Arg Ala Phe Asp Arg Ser Ile Ala Leu Asp Glu Cys Ser Ile Arg Arg 
            420                 425                 430         


Thr Ala Glu Asp Phe Glu Asn Gly Val Val Ile Lys Asn Glu Lys Leu 
        435                 440                 445             


Glu Asp Val Leu Ser Gly His Gln Leu Glu Glu Phe Leu Glu Phe Ala 
    450                 455                 460                 


Asn Arg Tyr Tyr Gln Glu Thr Ala Lys Ala Lys Asn Gly Leu Trp Phe 
465                 470                 475                 480 


Pro Glu Asn Ala Leu Leu Glu Arg Ala Asp Leu His Pro Pro Met Lys 
                485                 490                 495     


Asn Lys Ile Leu Asn Val Ile Val Gly Gln Ala Leu Gly Val Ser Pro 
            500                 505                 510         


Ala Glu Gly Thr Asp Phe Ile Glu Glu Ile Trp Asn Ser Lys Val Lys 
        515                 520                 525             


Gly Arg Ser Thr Val His Ser Ile Cys Asn Ala Ile Glu Asn Glu Arg 
    530                 535                 540                 


Lys Thr Tyr Gly Pro Tyr Phe Ser Glu Asp Tyr Lys Phe Val Lys Thr 
545                 550                 555                 560 


Ala Leu Lys Glu Gly Lys Thr Glu Lys Glu Leu Ser Lys Lys Phe Ala 
                565                 570                 575     


Ala Val Ile Lys Val Leu Lys Met Val Ser Glu Val Val Pro Phe Ile 
            580                 585                 590         


Gly Lys Glu Leu Arg Leu Ser Asp Glu Ala Gln Ser Lys Phe Asp Asn 
        595                 600                 605             


Pro Tyr Ser Leu Ala Gln Leu Tyr Asn Leu Ile Glu Thr Glu Arg Asn 
    610                 615                 620                 


Gly Phe Ser Lys Val Ser Leu Ala Ala His Leu Glu Asn Ala Trp Arg 
625                 630                 635                 640 


Met Thr Met Thr Asp Gly Ser Ala Gln Cys Cys Arg Leu Pro Ala Asp 
                645                 650                 655     


Cys Val Arg Pro Phe Asp Gly Phe Ile Arg Lys Ala Ile Asp Arg Asn 
            660                 665                 670         


Ser Trp Glu Val Ala Lys Arg Ile Ala Glu Glu Val Lys Lys Ser Val 
        675                 680                 685             


Asp Phe Thr Asn Gly Thr Val Lys Ile Pro Val Ala Ile Glu Ala Asn 
    690                 695                 700                 


Ser Phe Asn Phe Thr Ala Ser Leu Thr Asp Leu Lys Tyr Ile Gln Leu 
705                 710                 715                 720 


Lys Glu Gln Lys Leu Lys Lys Lys Leu Glu Asp Ile Gln Arg Asn Glu 
                725                 730                 735     


Glu Asn Gln Glu Lys Arg Trp Leu Ser Lys Glu Glu Arg Ile Arg Ala 
            740                 745                 750         


Asp Ser His Gly Ile Cys Ala Tyr Thr Gly Arg Pro Leu Asp Asp Val 
        755                 760                 765             


Gly Glu Ile Asp His Ile Ile Pro Arg Ser Leu Thr Leu Lys Lys Ser 
    770                 775                 780                 


Glu Ser Ile Tyr Asn Ser Glu Val Asn Leu Ile Phe Val Ser Ala Gln 
785                 790                 795                 800 


Gly Asn Gln Glu Lys Lys Asn Asn Ile Tyr Leu Leu Ser Asn Leu Ala 
                805                 810                 815     


Lys Asn Tyr Leu Ala Ala Val Phe Gly Ala Ser Asp Leu Ser Gln Ile 
            820                 825                 830         


Thr Asn Glu Ile Glu Ser Thr Val Leu Gln Leu Lys Ala Ala Gly Arg 
        835                 840                 845             


Leu Gly Tyr Phe Asp Leu Leu Ser Glu Lys Glu Arg Ala Cys Ala Arg 
    850                 855                 860                 


His Ala Leu Phe Leu Asn Ser Asp Ser Glu Ala Arg Arg Ala Val Ile 
865                 870                 875                 880 


Asp Val Leu Gly Ser Arg Arg Lys Ala Ser Val Asn Gly Thr Gln Ala 
                885                 890                 895     


Trp Phe Val Arg Ser Ile Phe Ser Lys Val Arg Gln Ala Leu Ala Ala 
            900                 905                 910         


Trp Thr Gln Glu Thr Gly Asn Glu Leu Ile Phe Asp Ala Ile Ser Val 
        915                 920                 925             


Pro Ala Ala Asp Ser Ser Glu Met Arg Lys Arg Phe Ala Glu Tyr Arg 
    930                 935                 940                 


Pro Glu Phe Arg Lys Pro Lys Val Gln Pro Val Ala Ser His Ser Ile 
945                 950                 955                 960 


Asp Ala Met Cys Ile Tyr Leu Ala Ala Cys Ser Asp Pro Phe Lys Thr 
                965                 970                 975     


Lys Arg Met Gly Ser Gln Leu Ala Ile Tyr Glu Pro Ile Asn Phe Asp 
            980                 985                 990         


Asn Leu Phe Thr Gly Ser Cys Gln  Val Ile Gln Asn Thr  Pro Arg Asn 
        995                 1000                 1005             


Phe Ser  Asp Lys Thr Asn Ile  Ala Asn Ser Pro Ile  Phe Lys Glu 
    1010                 1015                 1020             


Thr Ile  Tyr Ala Glu Arg Phe  Leu Asp Ile Ile Val  Ser Arg Gly 
    1025                 1030                 1035             


Glu Ile  Phe Ile Gly Tyr Pro  Ser Asn Met Pro Phe  Glu Glu Lys 
    1040                 1045                 1050             


Pro Asn  Arg Ile Ser Ile Gly  Gly Lys Asp Pro Phe  Ser Ile Leu 
    1055                 1060                 1065             


Ser Val  Leu Gly Ala Tyr Leu  Asp Lys Ala Pro Ser  Ser Glu Lys 
    1070                 1075                 1080             


Glu Lys  Leu Thr Ile Tyr Arg  Val Val Lys Asn Lys  Ala Phe Glu 
    1085                 1090                 1095             


Leu Phe  Ser Lys Val Ala Gly  Ser Lys Phe Thr Ala  Glu Glu Asp 
    1100                 1105                 1110             


Lys Ala  Ala Lys Ile Leu Glu  Ala Leu His Phe Val  Thr Val Lys 
    1115                 1120                 1125             


Gln Asp  Val Ala Ala Thr Val  Ser Asp Leu Ile Lys  Ser Lys Lys 
    1130                 1135                 1140             


Glu Leu  Ser Lys Asp Ser Ile  Glu Asn Leu Ala Lys  Gln Lys Gly 
    1145                 1150                 1155             


Cys Leu  Lys Lys Val Glu Tyr  Ser Ser Lys Glu Phe  Lys Phe Lys 
    1160                 1165                 1170             


Gly Ser  Leu Ile Ile Pro Ala  Ala Val Glu Trp Gly  Lys Val Leu 
    1175                 1180                 1185             


Trp Asn  Val Phe Lys Glu Asn  Thr Ala Glu Glu Leu  Lys Asp Glu 
    1190                 1195                 1200             


Asn Ala  Leu Arg Lys Ala Leu  Glu Ala Ala Trp Pro  Ser Ser Phe 
    1205                 1210                 1215             


Gly Thr  Arg Asn Leu His Ser  Lys Ala Lys Arg Val  Phe Ser Leu 
    1220                 1225                 1230             


Pro Val  Val Ala Thr Gln Ser  Gly Ala Val Arg Ile  Arg Arg Lys 
    1235                 1240                 1245             


Thr Ala  Phe Gly Asp Phe Val  Tyr Gln Ser Gln Asp  Thr Asn Asn 
    1250                 1255                 1260             


Leu Tyr  Ser Ser Phe Pro Val  Lys Asn Gly Lys Leu  Asp Trp Ser 
    1265                 1270                 1275             


Ser Pro  Ile Ile His Pro Ala  Leu Gln Asn Arg Asn  Leu Thr Ala 
    1280                 1285                 1290             


Tyr Gly  Tyr Arg Phe Val Asp  His Asp Arg Ser Ile  Ser Met Ser 
    1295                 1300                 1305             


Glu Phe  Arg Glu Val Tyr Asn  Lys Asp Asp Leu Met  Arg Ile Glu 
    1310                 1315                 1320             


Leu Ala  Gln Gly Thr Ser Ser  Arg Arg Tyr Leu Arg  Val Glu Met 
    1325                 1330                 1335             


Pro Gly  Glu Lys Phe Leu Ala  Trp Phe Gly Glu Asn  Ser Ile Ser 
    1340                 1345                 1350             


Leu Gly  Ser Ser Phe Lys Phe  Ser Val Ser Glu Val  Phe Asp Asn 
    1355                 1360                 1365             


Lys Ile  Tyr Thr Glu Asn Ala  Glu Phe Thr Lys Phe  Leu Pro Lys 
    1370                 1375                 1380             


Pro Arg  Glu Asp Asn Lys His  Asn Gly Thr Ile Phe  Phe Glu Leu 
    1385                 1390                 1395             


Val Gly  Pro Arg Val Ile Phe  Asn Tyr Ile Val Gly  Gly Ala Ala 
    1400                 1405                 1410             


Ser Ser  Leu Lys Glu Ile Phe  Ser Glu Ala Gly Lys  Glu Arg Ser 
    1415                 1420                 1425             


<210> 102
<211> 1442
<212> PRT
<213> Caenispirillum salinarum


<220>
<223> Caenispirillum salinarum AK4

<400> 102
Met Pro Val Leu Ser Pro Leu Ser Pro Asn Ala Ala Gln Gly Arg Arg 
1               5                   10                  15      


Arg Trp Ser Leu Ala Leu Asp Ile Gly Glu Gly Ser Ile Gly Trp Ala 
            20                  25                  30          


Val Ala Glu Val Asp Ala Glu Gly Arg Val Leu Gln Leu Thr Gly Thr 
        35                  40                  45              


Gly Val Thr Leu Phe Pro Ser Ala Trp Ser Asn Glu Asn Gly Thr Tyr 
    50                  55                  60                  


Val Ala His Gly Ala Ala Asp Arg Ala Val Arg Gly Gln Gln Gln Arg 
65                  70                  75                  80  


His Asp Ser Arg Arg Arg Arg Leu Ala Gly Leu Ala Arg Leu Cys Ala 
                85                  90                  95      


Pro Val Leu Glu Arg Ser Pro Glu Asp Leu Lys Asp Leu Thr Arg Thr 
            100                 105                 110         


Pro Pro Lys Ala Asp Pro Arg Ala Ile Phe Phe Leu Arg Ala Asp Ala 
        115                 120                 125             


Ala Arg Arg Pro Leu Asp Gly Pro Glu Leu Phe Arg Val Leu His His 
    130                 135                 140                 


Met Ala Ala His Arg Gly Ile Arg Leu Ala Glu Leu Gln Glu Val Asp 
145                 150                 155                 160 


Pro Pro Pro Glu Ser Asp Ala Asp Asp Ala Ala Pro Ala Ala Thr Glu 
                165                 170                 175     


Asp Glu Asp Gly Thr Arg Arg Ala Ala Ala Asp Glu Arg Ala Phe Arg 
            180                 185                 190         


Arg Leu Met Ala Glu His Met His Arg His Gly Thr Gln Pro Thr Cys 
        195                 200                 205             


Gly Glu Ile Met Ala Gly Arg Leu Arg Glu Thr Pro Ala Gly Ala Gln 
    210                 215                 220                 


Pro Val Thr Arg Ala Arg Asp Gly Leu Arg Val Gly Gly Gly Val Ala 
225                 230                 235                 240 


Val Pro Thr Arg Ala Leu Ile Glu Gln Glu Phe Asp Ala Ile Arg Ala 
                245                 250                 255     


Ile Gln Ala Pro Arg His Pro Asp Leu Pro Trp Asp Ser Leu Arg Arg 
            260                 265                 270         


Leu Val Leu Asp Gln Ala Pro Ile Ala Val Pro Pro Ala Thr Pro Cys 
        275                 280                 285             


Leu Phe Leu Glu Glu Leu Arg Arg Arg Gly Glu Thr Phe Gln Gly Arg 
    290                 295                 300                 


Thr Ile Thr Arg Glu Ala Ile Asp Arg Gly Leu Thr Val Asp Pro Leu 
305                 310                 315                 320 


Ile Gln Ala Leu Arg Ile Arg Glu Thr Val Gly Asn Leu Arg Leu His 
                325                 330                 335     


Glu Arg Ile Thr Glu Pro Asp Gly Arg Gln Arg Tyr Val Pro Arg Ala 
            340                 345                 350         


Met Pro Glu Leu Gly Leu Ser His Gly Glu Leu Thr Ala Pro Glu Arg 
        355                 360                 365             


Asp Thr Leu Val Arg Ala Leu Met His Asp Pro Asp Gly Leu Ala Ala 
    370                 375                 380                 


Lys Asp Gly Arg Ile Pro Tyr Thr Arg Leu Arg Lys Leu Ile Gly Tyr 
385                 390                 395                 400 


Asp Asn Ser Pro Val Cys Phe Ala Gln Glu Arg Asp Thr Ser Gly Gly 
                405                 410                 415     


Gly Ile Thr Val Asn Pro Thr Asp Pro Leu Met Ala Arg Trp Ile Asp 
            420                 425                 430         


Gly Trp Val Asp Leu Pro Leu Lys Ala Arg Ser Leu Tyr Val Arg Asp 
        435                 440                 445             


Val Val Ala Arg Gly Ala Asp Ser Ala Ala Leu Ala Arg Leu Leu Ala 
    450                 455                 460                 


Glu Gly Ala His Gly Val Pro Pro Val Ala Ala Ala Ala Val Pro Ala 
465                 470                 475                 480 


Ala Thr Ala Ala Ile Leu Glu Ser Asp Ile Met Gln Pro Gly Arg Tyr 
                485                 490                 495     


Ser Val Cys Pro Trp Ala Ala Glu Ala Ile Leu Asp Ala Trp Ala Asn 
            500                 505                 510         


Ala Pro Thr Glu Gly Phe Tyr Asp Val Thr Arg Gly Leu Phe Gly Phe 
        515                 520                 525             


Ala Pro Gly Glu Ile Val Leu Glu Asp Leu Arg Arg Ala Arg Gly Ala 
    530                 535                 540                 


Leu Leu Ala His Leu Pro Arg Thr Met Ala Ala Ala Arg Thr Pro Asn 
545                 550                 555                 560 


Arg Ala Ala Gln Gln Arg Gly Pro Leu Pro Ala Tyr Glu Ser Val Ile 
                565                 570                 575     


Pro Ser Gln Leu Ile Thr Ser Leu Arg Arg Ala His Lys Gly Arg Ala 
            580                 585                 590         


Ala Asp Trp Ser Ala Ala Asp Pro Glu Glu Arg Asn Pro Phe Leu Arg 
        595                 600                 605             


Thr Trp Thr Gly Asn Ala Ala Thr Asp His Ile Leu Asn Gln Val Arg 
    610                 615                 620                 


Lys Thr Ala Asn Glu Val Ile Thr Lys Tyr Gly Asn Arg Arg Gly Trp 
625                 630                 635                 640 


Asp Pro Leu Pro Ser Arg Ile Thr Val Glu Leu Ala Arg Glu Ala Lys 
                645                 650                 655     


His Gly Val Ile Arg Arg Asn Glu Ile Ala Lys Glu Asn Arg Glu Asn 
            660                 665                 670         


Glu Gly Arg Arg Lys Lys Glu Ser Ala Ala Leu Asp Thr Phe Cys Gln 
        675                 680                 685             


Asp Asn Thr Val Ser Trp Gln Ala Gly Gly Leu Pro Lys Glu Arg Ala 
    690                 695                 700                 


Ala Leu Arg Leu Arg Leu Ala Gln Arg Gln Glu Phe Phe Cys Pro Tyr 
705                 710                 715                 720 


Cys Ala Glu Arg Pro Lys Leu Arg Ala Thr Asp Leu Phe Ser Pro Ala 
                725                 730                 735     


Glu Thr Glu Ile Asp His Val Ile Glu Arg Arg Met Gly Gly Asp Gly 
            740                 745                 750         


Pro Asp Asn Leu Val Leu Ala His Lys Asp Cys Asn Asn Ala Lys Gly 
        755                 760                 765             


Lys Lys Thr Pro His Glu His Ala Gly Asp Leu Leu Asp Ser Pro Ala 
    770                 775                 780                 


Leu Ala Ala Leu Trp Gln Gly Trp Arg Lys Glu Asn Ala Asp Arg Leu 
785                 790                 795                 800 


Lys Gly Lys Gly His Lys Ala Arg Thr Pro Arg Glu Asp Lys Asp Phe 
                805                 810                 815     


Met Asp Arg Val Gly Trp Arg Phe Glu Glu Asp Ala Arg Ala Lys Ala 
            820                 825                 830         


Glu Glu Asn Gln Glu Arg Arg Gly Arg Arg Met Leu His Asp Thr Ala 
        835                 840                 845             


Arg Ala Thr Arg Leu Ala Arg Leu Tyr Leu Ala Ala Ala Val Met Pro 
    850                 855                 860                 


Glu Asp Pro Ala Glu Ile Gly Ala Pro Pro Val Glu Thr Pro Pro Ser 
865                 870                 875                 880 


Pro Glu Asp Pro Thr Gly Tyr Thr Ala Ile Tyr Arg Thr Ile Ser Arg 
                885                 890                 895     


Val Gln Pro Val Asn Gly Ser Val Thr His Met Leu Arg Gln Arg Leu 
            900                 905                 910         


Leu Gln Arg Asp Lys Asn Arg Asp Tyr Gln Thr His His Ala Glu Asp 
        915                 920                 925             


Ala Cys Leu Leu Leu Leu Ala Gly Pro Ala Val Val Gln Ala Phe Asn 
    930                 935                 940                 


Thr Glu Ala Ala Gln His Gly Ala Asp Ala Pro Asp Asp Arg Pro Val 
945                 950                 955                 960 


Asp Leu Met Pro Thr Ser Asp Ala Tyr His Gln Gln Arg Arg Ala Arg 
                965                 970                 975     


Ala Leu Gly Arg Val Pro Leu Ala Thr Val Asp Ala Ala Leu Ala Asp 
            980                 985                 990         


Ile Val Met Pro Glu Ser Asp Arg  Gln Asp Pro Glu Thr  Gly Arg Val 
        995                 1000                 1005             


His Trp  Arg Leu Thr Arg Ala  Gly Arg Gly Leu Lys  Arg Arg Ile 
    1010                 1015                 1020             


Asp Asp  Leu Thr Arg Asn Cys  Val Ile Leu Ser Arg  Pro Arg Arg 
    1025                 1030                 1035             


Pro Ser  Glu Thr Gly Thr Pro  Gly Ala Leu His Asn  Ala Thr His 
    1040                 1045                 1050             


Tyr Gly  Arg Arg Glu Ile Thr  Val Asp Gly Arg Thr  Asp Thr Val 
    1055                 1060                 1065             


Val Thr  Gln Arg Met Asn Ala  Arg Asp Leu Val Ala  Leu Leu Asp 
    1070                 1075                 1080             


Asn Ala  Lys Ile Val Pro Ala  Ala Arg Leu Asp Ala  Ala Ala Pro 
    1085                 1090                 1095             


Gly Asp  Thr Ile Leu Lys Glu  Ile Cys Thr Glu Ile  Ala Asp Arg 
    1100                 1105                 1110             


His Asp  Arg Val Val Asp Pro  Glu Gly Thr His Ala  Arg Arg Trp 
    1115                 1120                 1125             


Ile Ser  Ala Arg Leu Ala Ala  Leu Val Pro Ala His  Ala Glu Ala 
    1130                 1135                 1140             


Val Ala  Arg Asp Ile Ala Glu  Leu Ala Asp Leu Asp  Ala Leu Ala 
    1145                 1150                 1155             


Asp Ala  Asp Arg Thr Pro Glu  Gln Glu Ala Arg Arg  Ser Ala Leu 
    1160                 1165                 1170             


Arg Gln  Ser Pro Tyr Leu Gly  Arg Ala Ile Ser Ala  Lys Lys Ala 
    1175                 1180                 1185             


Asp Gly  Arg Ala Arg Ala Arg  Glu Gln Glu Ile Leu  Thr Arg Ala 
    1190                 1195                 1200             


Leu Leu  Asp Pro His Trp Gly  Pro Arg Gly Leu Arg  His Leu Ile 
    1205                 1210                 1215             


Met Arg  Glu Ala Arg Ala Pro  Ser Leu Val Arg Ile  Arg Ala Asn 
    1220                 1225                 1230             


Lys Thr  Asp Ala Phe Gly Arg  Pro Val Pro Asp Ala  Ala Val Trp 
    1235                 1240                 1245             


Val Lys  Thr Asp Gly Asn Ala  Val Ser Gln Leu Trp  Arg Leu Thr 
    1250                 1255                 1260             


Ser Val  Val Thr Asp Asp Gly  Arg Arg Ile Pro Leu  Pro Lys Pro 
    1265                 1270                 1275             


Ile Glu  Lys Arg Ile Glu Ile  Ser Asn Leu Glu Tyr  Ala Arg Leu 
    1280                 1285                 1290             


Asn Gly  Leu Asp Glu Gly Ala  Gly Val Thr Gly Asn  Asn Ala Pro 
    1295                 1300                 1305             


Pro Arg  Pro Leu Arg Gln Asp  Ile Asp Arg Leu Thr  Pro Leu Trp 
    1310                 1315                 1320             


Arg Asp  His Gly Thr Ala Pro  Gly Gly Tyr Leu Gly  Thr Ala Val 
    1325                 1330                 1335             


Gly Glu  Leu Glu Asp Lys Ala  Arg Ser Ala Leu Arg  Gly Lys Ala 
    1340                 1345                 1350             


Met Arg  Gln Thr Leu Thr Asp  Ala Gly Ile Thr Ala  Glu Ala Gly 
    1355                 1360                 1365             


Trp Arg  Leu Asp Ser Glu Gly  Ala Val Cys Asp Leu  Glu Val Ala 
    1370                 1375                 1380             


Lys Gly  Asp Thr Val Lys Lys  Asp Gly Lys Thr Tyr  Lys Val Gly 
    1385                 1390                 1395             


Val Ile  Thr Gln Gly Ile Phe  Gly Met Pro Val Asp  Ala Ala Gly 
    1400                 1405                 1410             


Ser Ala  Pro Arg Thr Pro Glu  Asp Cys Glu Lys Phe  Glu Glu Gln 
    1415                 1420                 1425             


Tyr Gly  Ile Lys Pro Trp Lys  Ala Lys Gly Ile Pro  Leu Ala 
    1430                 1435                 1440         


<210> 103
<211> 984
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 1098

<400> 103
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 104
<211> 984
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 111-3

<400> 104
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asn Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 105
<211> 987
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 132-6

<400> 105
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asn Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Asn Glu Leu Arg 
            980                 985         


<210> 106
<211> 984
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 151-9

<400> 106
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asn Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asn Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 107
<211> 984
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 1909

<400> 107
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Cys Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 108
<211> 965
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 1957

<400> 108
Met Lys Ile Ile Gly Phe Asn Leu Gly Ile Ala Asn Ile Gly Trp Ala 
1               5                   10                  15      


Leu Arg Glu Asn Asp Glu Ile Ile Asp Cys Gly Val Arg Val Phe Asp 
            20                  25                  30          


Ile Pro Glu Asn Pro Lys Asn Gly Asn Ser Leu Ala Leu Glu Arg Arg 
        35                  40                  45              


Glu Asn Lys Ala Arg Met Lys Ile Val Lys Arg Lys Lys Ala Arg Met 
    50                  55                  60                  


Leu Ala Thr Lys Thr Phe Leu Lys Lys Glu Leu Asn Val Asp Leu Ser 
65                  70                  75                  80  


Lys Leu Phe Leu Ile Gly Ser Thr Gln Ser Ile Tyr Glu Leu Arg Thr 
                85                  90                  95      


Lys Ala Leu Ser Ser Leu Ile Ser Lys Glu Glu Leu Ser Ala Ile Ile 
            100                 105                 110         


Leu His Ile Ala Lys His Arg Gly Tyr Asp Asp Ser Ala Leu Lys Asn 
        115                 120                 125             


Glu Asn Gly Thr Ile Ile Glu Ala Leu Asn Lys Asn Lys Glu Ala Met 
    130                 135                 140                 


Leu Lys Phe Lys Ser Val Gly Glu Tyr Phe Tyr Lys Asn Phe Val Gln 
145                 150                 155                 160 


Asn Lys Glu Val Lys Lys Ile Arg Asn Thr Thr Glu Asp Tyr Ser Asn 
                165                 170                 175     


Ser Val Pro Arg Ser Leu Leu Lys Gln Glu Leu Asp Leu Ile Leu Asp 
            180                 185                 190         


Lys Gln Lys Glu Leu Gly Leu Ile Lys Asn Ala Asp Phe Lys Glu Lys 
        195                 200                 205             


Leu Phe Glu Ile Ile Phe Phe Lys Arg Pro Leu Lys Asp Phe Ser Asn 
    210                 215                 220                 


Lys Ile Gly Asn Cys Ile Phe Phe Glu Asn Glu Lys Arg Ala Ala Lys 
225                 230                 235                 240 


Asn Thr Ile Ser Ala Cys Glu Phe Val Ala Leu Gly Lys Val Val Asn 
                245                 250                 255     


Leu Leu Lys Ser Ile Glu Lys Asp Ile Gly Ile Val Tyr Glu Lys Asp 
            260                 265                 270         


Ser Ile Asn Glu Ile Met Ser Ile Ile Leu Asp Lys Thr Ser Ile Ser 
        275                 280                 285             


Tyr Lys Lys Ile Arg Asp Ile Leu Asn Leu Pro Gln Asp Ile Asn Phe 
    290                 295                 300                 


Lys Gly Leu Asp Tyr Ser Lys Asn Asn Ala Glu Asn Ser Lys Leu Val 
305                 310                 315                 320 


Asp Leu Lys Lys Leu Asn Glu Phe Lys Lys Ala Leu Gly Asp Gly Phe 
                325                 330                 335     


Ala Asn Leu Asp Lys Asp Ile Leu Asp Ser Ile Ala Thr Asp Ile Thr 
            340                 345                 350         


Leu Thr Lys Asp Thr Ala Thr Leu Lys Glu Lys Leu Lys Asn Tyr Asn 
        355                 360                 365             


Val Leu Asn Ala Glu Gln Ile Glu Lys Leu Ser Glu Leu Val Phe Asn 
    370                 375                 380                 


Asp His Ile Asn Leu Ser Leu Lys Ala Leu Lys Gln Ile Ile Pro Leu 
385                 390                 395                 400 


Met Tyr Glu Gly Lys Arg Tyr Asp Glu Ala Cys Glu Leu Cys Asn Phe 
                405                 410                 415     


Thr Ile Ala Lys Asn Gln Glu Lys Asn Glu Tyr Leu Pro Leu Phe Glu 
            420                 425                 430         


Lys Thr Arg Phe Ala Lys Asp Ile Ser Ser Pro Val Val Ile Arg Ala 
        435                 440                 445             


Ile Cys Glu Phe Arg Lys Leu Leu Asn Asp Ile Ile Arg Arg Tyr Gly 
    450                 455                 460                 


Ser Val His Lys Ile His Leu Glu Leu Thr Arg Asp Phe Gly Ile Ser 
465                 470                 475                 480 


Phe Asn Asp Arg Lys Lys Ile Ile Lys Glu Ile Glu Gln Asn Glu Gln 
                485                 490                 495     


Ser Arg Ile Lys Ala Leu Glu Thr Ile Lys Glu Leu Lys Leu Glu Glu 
            500                 505                 510         


Thr Ser Lys Asn Ile Gln Ile Val Arg Leu Phe Glu Asp Gln Lys Gly 
        515                 520                 525             


Ile Cys Pro Tyr Ser Gly Leu Lys Met Asp Leu Lys Cys Leu Asp Glu 
    530                 535                 540                 


Leu Val Ile Asp Tyr Ile Arg Pro Tyr Asn Arg Ser Leu Asp Asp Ser 
545                 550                 555                 560 


Tyr Ser Asn Lys Ile Leu Thr Phe Lys Lys Leu Asn Asp Leu Lys Gln 
                565                 570                 575     


Gly Lys Thr Pro Phe Glu Ala Phe Gly Glu Asp Glu Lys Leu Trp Ala 
            580                 585                 590         


Glu Ile Asn Glu Arg Ile Lys Glu Tyr Asn Gly Lys Lys Arg Phe Lys 
        595                 600                 605             


Ile Phe Asp Lys Phe Phe Lys Asp Lys Lys Pro Phe Asp Phe Thr Glu 
    610                 615                 620                 


Gln Thr Leu Gln Asp Thr Arg Trp Leu Thr Lys Leu Val Ala Ser Tyr 
625                 630                 635                 640 


Leu Asn Glu Tyr Leu Leu Phe Leu Pro Ile Asn Glu Asp Glu Asn Thr 
                645                 650                 655     


Ala Leu Gly Tyr Gly Glu Lys Gly Ser Lys Gln His Val Val Leu Ser 
            660                 665                 670         


Ser Gly Met Ile Thr Gln Met Leu Arg Asn Phe Trp Tyr Leu Gly Phe 
        675                 680                 685             


Lys Asn His Lys Asp Tyr Lys Asn Asn Ala Met Asp Ala Ile Ile Val 
    690                 695                 700                 


Ala Phe Thr Thr Asn Ser Ile Ile Phe Ala Phe Asn Asn Phe Lys Lys 
705                 710                 715                 720 


Glu Leu Asp Leu Ala Lys Ala Glu Phe Tyr Ala Asn Lys Ile Ser Glu 
                725                 730                 735     


Ser Asp Tyr Leu Leu Lys Arg Lys Phe Leu Pro Pro Phe Ser Gly Phe 
            740                 745                 750         


Lys Glu Gln Ala Leu Glu Lys Val Lys Asn Ile Phe Val Ser His Ser 
        755                 760                 765             


Leu Lys Ile Lys Asn Lys Gly Thr Leu His Glu Leu Thr Pro Leu Lys 
    770                 775                 780                 


Ile Lys Glu Leu Lys Asn Thr Tyr Gly Asp Leu Asp Leu Ala Val Lys 
785                 790                 795                 800 


Leu Gly Lys Ile Arg Lys Tyr Asn Asp Lys Tyr Tyr Ala Asn Ala Lys 
                805                 810                 815     


Gly Ser Leu Val Arg Thr Asp Leu Phe Ala Asp Lys Glu Asn Lys Phe 
            820                 825                 830         


His Ala Val Ser Ile Tyr Lys Ala Asp Phe Ser Thr Lys Lys Leu Pro 
        835                 840                 845             


Asn Lys Thr Pro Ala Thr Thr Ser Asn Gly Glu Thr Lys Glu Gly Ile 
    850                 855                 860                 


Glu Met Asn Glu Asn Tyr Asn Phe Cys Met Ser Leu Tyr Lys Asn Thr 
865                 870                 875                 880 


Pro Ile Ser Val Lys Ile Lys Gly Met Lys Glu Pro Ile Ile Cys Tyr 
                885                 890                 895     


Tyr His Gly Phe Asn Thr Ser Gly Ser Lys Ile Thr Tyr Lys Lys His 
            900                 905                 910         


Asp Asn Asn Tyr His Asn Leu Ser Glu Asp Glu Met Val Val Phe Arg 
        915                 920                 925             


Lys Asn Asp Lys Glu Ser Ile Val Val Gly Lys Ile Leu Glu Ile Lys 
    930                 935                 940                 


Lys Tyr Ser Ile Ser Pro Ser Gly Glu Leu Ser Leu Ile Glu Asn Glu 
945                 950                 955                 960 


Glu Arg Lys Trp Phe 
                965 


<210> 109
<211> 984
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 2692

<400> 109
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Thr Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 110
<211> 984
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 59-2

<400> 110
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Gly Lys 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Thr Gln Ser Phe Leu Lys Tyr Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Ser Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 111
<211> 965
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 67-8

<400> 111
Met Lys Ile Ile Gly Phe Asn Leu Gly Ile Ala Asn Ile Gly Trp Ala 
1               5                   10                  15      


Leu Arg Glu Asn Asp Glu Ile Ile Asp Cys Gly Val Arg Val Phe Asp 
            20                  25                  30          


Ile Pro Glu Asn Pro Lys Asn Gly Asn Ser Leu Ala Leu Glu Arg Arg 
        35                  40                  45              


Glu Asn Lys Ala Arg Met Lys Ile Val Lys Arg Lys Lys Ala Arg Met 
    50                  55                  60                  


Leu Ala Thr Lys Thr Phe Leu Lys Lys Glu Leu Asn Val Asp Leu Ser 
65                  70                  75                  80  


Lys Leu Phe Leu Ile Gly Ser Thr Gln Ser Ile Tyr Glu Leu Arg Thr 
                85                  90                  95      


Lys Ala Leu Ser Ser Leu Ile Ser Lys Glu Glu Leu Ser Ala Ile Ile 
            100                 105                 110         


Leu His Ile Ala Lys His Arg Gly Tyr Asp Asp Ser Ala Leu Lys Asn 
        115                 120                 125             


Glu Asn Gly Thr Ile Ile Glu Ala Leu Asn Lys Asn Lys Glu Ala Met 
    130                 135                 140                 


Leu Lys Phe Lys Ser Val Gly Glu Tyr Phe Tyr Lys Asn Phe Val Gln 
145                 150                 155                 160 


Asn Lys Glu Val Lys Lys Ile Arg Asn Thr Thr Glu Asp Tyr Ser Asn 
                165                 170                 175     


Ser Val Pro Arg Ser Leu Leu Lys Gln Glu Leu Asp Leu Ile Leu Asp 
            180                 185                 190         


Lys Gln Lys Glu Leu Gly Leu Ile Lys Asn Ala Asp Phe Lys Ala Lys 
        195                 200                 205             


Leu Phe Glu Ile Ile Phe Phe Lys Arg Pro Leu Lys Asp Phe Ser Asn 
    210                 215                 220                 


Lys Ile Gly Asn Cys Ile Phe Phe Glu Asn Glu Lys Arg Ala Ala Lys 
225                 230                 235                 240 


Asn Thr Ile Ser Ala Cys Glu Phe Val Ala Leu Gly Lys Val Val Asn 
                245                 250                 255     


Leu Leu Lys Ser Ile Glu Lys Asp Ile Gly Ile Val Tyr Glu Lys Asp 
            260                 265                 270         


Ser Ile Asn Glu Ile Met Ser Ile Ile Leu Asp Lys Thr Ser Ile Ser 
        275                 280                 285             


Tyr Lys Lys Ile Arg Asp Ile Leu Asn Leu Pro Gln Asp Ile Asn Phe 
    290                 295                 300                 


Lys Gly Leu Asp Tyr Ser Lys Asn Asn Ala Glu Asn Ser Lys Leu Val 
305                 310                 315                 320 


Asp Leu Lys Lys Leu Asn Glu Phe Lys Lys Ala Leu Gly Asp Gly Phe 
                325                 330                 335     


Ala Asn Leu Asp Lys Asp Ile Leu Asp Ser Ile Ala Thr Asp Ile Thr 
            340                 345                 350         


Leu Thr Lys Asp Thr Ala Thr Leu Lys Glu Lys Leu Lys Asn Tyr Asn 
        355                 360                 365             


Val Leu Asn Ala Glu Gln Ile Glu Lys Leu Ser Glu Leu Val Phe Asn 
    370                 375                 380                 


Asp His Ile Asn Leu Ser Leu Lys Ala Leu Lys Gln Ile Ile Pro Leu 
385                 390                 395                 400 


Met Tyr Glu Gly Lys Arg Tyr Asp Glu Ala Cys Glu Leu Cys Asn Phe 
                405                 410                 415     


Thr Ile Ala Lys Asn Gln Glu Lys Asn Glu Tyr Leu Pro Leu Phe Glu 
            420                 425                 430         


Lys Thr Arg Phe Ala Lys Asp Ile Ser Ser Pro Val Val Ile Arg Ala 
        435                 440                 445             


Ile Cys Glu Phe Arg Lys Leu Leu Asn Asp Ile Ile Arg Arg Tyr Gly 
    450                 455                 460                 


Ser Val His Lys Ile His Leu Glu Leu Thr Arg Asp Phe Gly Ile Ser 
465                 470                 475                 480 


Phe Asn Asp Arg Lys Lys Ile Ile Lys Glu Ile Glu Gln Asn Glu Gln 
                485                 490                 495     


Ser Arg Ile Lys Ala Leu Glu Thr Ile Lys Glu Leu Lys Leu Glu Glu 
            500                 505                 510         


Thr Ser Lys Asn Ile Gln Ile Val Arg Leu Phe Glu Asp Gln Lys Gly 
        515                 520                 525             


Ile Cys Pro Tyr Ser Gly Leu Lys Met Asp Leu Lys Cys Leu Asp Glu 
    530                 535                 540                 


Leu Val Ile Asp Tyr Ile Arg Pro Tyr Asn Arg Ser Leu Asp Asp Ser 
545                 550                 555                 560 


Tyr Ser Asn Lys Val Leu Thr Phe Lys Lys Leu Asn Asp Leu Lys Gln 
                565                 570                 575     


Gly Lys Thr Pro Phe Glu Ala Phe Gly Glu Asp Glu Lys Leu Trp Ala 
            580                 585                 590         


Glu Ile Asn Glu Arg Ile Lys Glu Tyr Asn Gly Lys Lys Arg Phe Lys 
        595                 600                 605             


Ile Phe Asp Lys Phe Phe Lys Asp Lys Lys Pro Phe Asp Phe Thr Glu 
    610                 615                 620                 


Gln Thr Leu Gln Asp Thr Arg Trp Leu Thr Lys Leu Val Ala Ser Tyr 
625                 630                 635                 640 


Leu Asn Glu Tyr Leu Ser Phe Leu Pro Ile Ser Glu Asp Glu Asn Thr 
                645                 650                 655     


Ala Leu Gly Tyr Gly Glu Lys Gly Ser Lys Gln His Val Val Leu Ser 
            660                 665                 670         


Ser Gly Met Ile Thr Gln Met Leu Arg Asn Phe Trp Tyr Leu Gly Phe 
        675                 680                 685             


Lys Asn His Lys Asn Tyr Lys Asn Asn Ala Met Asp Ala Ile Ile Val 
    690                 695                 700                 


Ala Phe Thr Thr Asn Ser Ile Ile Phe Ala Phe Asn Asn Phe Lys Lys 
705                 710                 715                 720 


Glu Leu Asp Leu Ala Lys Ala Glu Phe Tyr Ala Asn Lys Ile Ser Glu 
                725                 730                 735     


Ser Asp Tyr Leu Leu Lys Arg Lys Phe Leu Pro Pro Phe Ser Gly Phe 
            740                 745                 750         


Lys Glu Gln Ala Leu Glu Lys Val Lys Asn Ile Phe Val Ser His Ser 
        755                 760                 765             


Leu Lys Ile Lys Asn Lys Gly Thr Leu His Glu Leu Thr Pro Leu Lys 
    770                 775                 780                 


Ile Lys Glu Leu Lys Asn Thr Tyr Gly Asp Leu Asp Leu Ala Val Lys 
785                 790                 795                 800 


Leu Gly Lys Ile Arg Lys Tyr Asn Asp Lys Tyr Tyr Ala Asn Thr Lys 
                805                 810                 815     


Gly Ser Leu Val Arg Thr Asp Leu Phe Val Asp Lys Glu Asn Lys Phe 
            820                 825                 830         


His Ala Val Ser Ile Tyr Lys Ala Asp Phe Ser Thr Lys Lys Leu Pro 
        835                 840                 845             


Asn Lys Thr Pro Ala Thr Thr Ser Asn Gly Glu Thr Lys Glu Gly Ile 
    850                 855                 860                 


Glu Met Asn Glu Asn Tyr Asn Phe Cys Met Ser Leu Tyr Lys Asn Thr 
865                 870                 875                 880 


Pro Val Ser Val Lys Ile Lys Gly Met Lys Glu Pro Ile Ile Cys Tyr 
                885                 890                 895     


Tyr His Gly Phe Asn Thr Ser Gly Ser Lys Ile Thr Tyr Lys Lys His 
            900                 905                 910         


Asp Asn Asn Tyr His Asn Leu Ser Glu Asp Glu Met Val Val Phe Arg 
        915                 920                 925             


Lys Asn Asp Lys Glu Ser Ile Val Val Gly Lys Ile Leu Glu Ile Lys 
    930                 935                 940                 


Lys Tyr Ser Ile Ser Pro Ser Gly Glu Leu Ser Leu Ile Glu Asn Glu 
945                 950                 955                 960 


Lys Arg Lys Trp Phe 
                965 


<210> 112
<211> 965
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 80352

<400> 112
Met Lys Ile Ile Gly Phe Asn Leu Gly Ile Ala Asn Ile Gly Trp Ala 
1               5                   10                  15      


Leu Arg Glu Asn Asp Glu Ile Ile Asp Cys Gly Val Arg Val Phe Asp 
            20                  25                  30          


Ile Pro Glu Asn Pro Lys Asn Gly Asn Ser Leu Ala Leu Glu Arg Arg 
        35                  40                  45              


Glu Asn Lys Ala Arg Met Lys Ile Val Lys Arg Lys Lys Ala Arg Met 
    50                  55                  60                  


Leu Ala Thr Lys Thr Phe Leu Lys Lys Glu Leu Asn Val Asp Leu Ser 
65                  70                  75                  80  


Lys Leu Phe Leu Ile Gly Ser Thr Gln Ser Ile Tyr Glu Leu Arg Thr 
                85                  90                  95      


Lys Ala Leu Ser Ser Leu Ile Ser Lys Glu Glu Leu Ser Ala Ile Ile 
            100                 105                 110         


Leu His Ile Ala Lys His Arg Gly Tyr Asp Asp Ser Ala Leu Lys Asn 
        115                 120                 125             


Glu Asn Gly Thr Ile Ile Glu Ala Leu Asn Lys Asn Lys Glu Ala Met 
    130                 135                 140                 


Leu Lys Phe Lys Ser Val Gly Glu Tyr Phe Tyr Lys Asn Phe Val Gln 
145                 150                 155                 160 


Asn Lys Glu Val Lys Lys Ile Arg Asn Thr Thr Glu Asp Tyr Ser Asn 
                165                 170                 175     


Ser Val Pro Arg Ser Leu Leu Lys Gln Glu Leu Asp Leu Ile Leu Asp 
            180                 185                 190         


Lys Gln Lys Glu Leu Gly Leu Ile Lys Asn Ala Asp Phe Lys Ala Lys 
        195                 200                 205             


Leu Phe Glu Ile Ile Phe Phe Lys Arg Pro Leu Lys Asp Phe Ser Asn 
    210                 215                 220                 


Lys Ile Gly Asn Cys Ile Phe Phe Glu Asn Glu Lys Arg Ala Ala Lys 
225                 230                 235                 240 


Asn Thr Ile Ser Ala Cys Glu Phe Val Ala Leu Gly Lys Val Val Asn 
                245                 250                 255     


Leu Leu Lys Ser Ile Glu Lys Asp Ile Gly Ile Val Tyr Glu Lys Asp 
            260                 265                 270         


Ser Ile Asn Glu Ile Met Ser Ile Ile Leu Asp Lys Thr Ser Ile Ser 
        275                 280                 285             


Tyr Lys Lys Ile Arg Asp Ile Leu Asn Leu Pro Gln Asp Ile Asn Phe 
    290                 295                 300                 


Lys Gly Leu Asp Tyr Ser Lys Asn Asn Val Glu Asn Ser Lys Leu Val 
305                 310                 315                 320 


Asp Leu Lys Lys Leu Asn Glu Phe Lys Lys Ala Leu Gly Asp Gly Phe 
                325                 330                 335     


Thr Asn Leu Asp Lys Asp Ile Leu Asp Ser Ile Ala Thr Asp Ile Thr 
            340                 345                 350         


Leu Thr Lys Asp Thr Ala Thr Leu Lys Glu Lys Leu Lys Asn Tyr Asn 
        355                 360                 365             


Val Leu Asn Ala Glu Gln Ile Glu Lys Leu Ser Glu Leu Val Phe Asn 
    370                 375                 380                 


Asp His Ile Asn Leu Ser Leu Lys Ala Leu Lys Gln Ile Ile Pro Leu 
385                 390                 395                 400 


Met Tyr Glu Gly Lys Arg Tyr Asp Glu Ala Cys Glu Leu Cys Asn Phe 
                405                 410                 415     


Thr Ile Ala Lys Asn Gln Glu Lys Asn Glu Tyr Leu Pro Leu Phe Glu 
            420                 425                 430         


Lys Thr Arg Phe Ala Lys Asp Ile Ser Ser Pro Val Val Ile Arg Ala 
        435                 440                 445             


Ile Cys Glu Phe Arg Lys Leu Leu Asn Asp Ile Ile Arg Arg Tyr Gly 
    450                 455                 460                 


Ser Val His Lys Ile His Leu Glu Leu Thr Arg Asp Phe Gly Ile Ser 
465                 470                 475                 480 


Phe Asn Asp Arg Lys Lys Ile Ile Lys Glu Ile Glu Gln Asn Glu Gln 
                485                 490                 495     


Ser Arg Ile Lys Ala Leu Glu Thr Ile Lys Glu Leu Lys Leu Glu Glu 
            500                 505                 510         


Thr Ser Lys Asn Ile Gln Ile Val Arg Leu Phe Glu Asp Gln Lys Gly 
        515                 520                 525             


Ile Cys Pro Tyr Ser Gly Leu Lys Met Asp Leu Lys Cys Leu Asp Glu 
    530                 535                 540                 


Leu Val Ile Asp Tyr Ile Arg Pro Tyr Asn Arg Ser Leu Asp Asp Ser 
545                 550                 555                 560 


Tyr Ser Asn Lys Val Leu Thr Phe Lys Lys Leu Asn Asp Leu Lys Gln 
                565                 570                 575     


Gly Lys Thr Pro Phe Glu Ala Phe Gly Glu Asp Glu Lys Leu Trp Ala 
            580                 585                 590         


Glu Ile Asn Glu Arg Ile Lys Glu Tyr Asn Gly Lys Lys Arg Phe Lys 
        595                 600                 605             


Ile Phe Asp Lys Phe Phe Lys Asp Lys Lys Pro Phe Asp Phe Thr Glu 
    610                 615                 620                 


Gln Thr Leu Gln Asp Thr Arg Trp Leu Thr Lys Leu Val Ala Ser Tyr 
625                 630                 635                 640 


Leu Asn Glu Tyr Leu Ser Phe Leu Pro Ile Ser Glu Asp Glu Asn Thr 
                645                 650                 655     


Ala Leu Gly Tyr Gly Glu Lys Gly Ser Lys Gln His Val Ile Leu Ser 
            660                 665                 670         


Ser Gly Met Ile Thr Gln Met Leu Arg Asn Phe Trp Tyr Leu Gly Phe 
        675                 680                 685             


Lys Asn His Lys Asp Tyr Lys Asn Asn Ala Met Asp Ala Ile Ile Val 
    690                 695                 700                 


Ala Phe Thr Thr Asn Ser Ile Ile Phe Thr Phe Asn Asn Phe Lys Lys 
705                 710                 715                 720 


Glu Leu Asp Leu Ala Lys Ala Glu Phe Tyr Ala Asn Lys Ile Ser Glu 
                725                 730                 735     


Ser Asp Tyr Leu Leu Lys Arg Lys Phe Leu Pro Pro Phe Ser Gly Phe 
            740                 745                 750         


Lys Glu Gln Ala Leu Glu Lys Val Lys Asn Ile Phe Val Ser His Ser 
        755                 760                 765             


Leu Lys Ile Lys Asn Lys Gly Thr Leu His Glu Leu Thr Pro Leu Lys 
    770                 775                 780                 


Ile Lys Glu Leu Lys Asn Thr Tyr Gly Asp Leu Asp Leu Ala Val Lys 
785                 790                 795                 800 


Leu Gly Lys Ile Arg Lys Tyr Asn Asp Lys Tyr Tyr Ala Asn Ala Lys 
                805                 810                 815     


Gly Ser Leu Val Arg Thr Asp Leu Phe Ala Asp Lys Glu Asn Lys Phe 
            820                 825                 830         


His Ala Val Ser Ile Tyr Lys Ala Asp Phe Ser Thr Lys Lys Leu Pro 
        835                 840                 845             


Asn Lys Thr Pro Ala Thr Thr Ser Asn Gly Glu Thr Lys Glu Gly Ile 
    850                 855                 860                 


Glu Met Asn Glu Asn Tyr Asn Phe Cys Met Ser Leu Tyr Lys Asn Thr 
865                 870                 875                 880 


Pro Ile Ser Val Lys Ile Lys Gly Met Lys Glu Pro Ile Ile Cys Tyr 
                885                 890                 895     


Tyr His Gly Phe Asn Thr Ser Gly Ser Lys Ile Thr Tyr Lys Lys His 
            900                 905                 910         


Asp Asn Asn Tyr His Asn Leu Ser Glu Asp Glu Met Val Val Phe Arg 
        915                 920                 925             


Lys Asn Asp Lys Glu Ser Ile Val Val Gly Lys Ile Leu Glu Ile Lys 
    930                 935                 940                 


Lys Tyr Ser Ile Ser Pro Ser Gly Glu Leu Ser Leu Ile Glu Asn Glu 
945                 950                 955                 960 


Glu Arg Lys Trp Phe 
                965 


<210> 113
<211> 987
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 80352

<400> 113
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Thr Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Glu Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Asn Glu Leu Arg 
            980                 985         


<210> 114
<211> 984
<212> PRT
<213> Campylobacter jejuni

<400> 114
Met Ala Lys Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Ile Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ile Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Gly Lys 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Leu Tyr Thr Lys Asp Asp Leu 
        275                 280                 285             


Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu Thr Tyr Lys 
    290                 295                 300                 


Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu Phe Lys Gly 
305                 310                 315                 320 


Glu Lys Gly Asn Tyr Phe Ile Glu Phe Lys Lys Tyr Lys Glu Phe Ile 
                325                 330                 335     


Lys Ala Leu Gly Glu His Ser Leu Ser Gln Asp Asp Leu Asn Glu Ile 
            340                 345                 350         


Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu Lys Lys Ala 
        355                 360                 365             


Leu Ala Lys Tyr Asp Leu Asn Glu Asn Gln Ile Asp Asn Leu Ser Lys 
    370                 375                 380                 


Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala Leu Lys Leu 
385                 390                 395                 400 


Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu Ala Cys Asn 
                405                 410                 415     


Glu Leu Thr Leu Lys Val Ala Ile Asn Glu Asp Lys Lys Asp Phe Leu 
            420                 425                 430         


Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr Asn Pro Val 
        435                 440                 445             


Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn Ala Leu Leu 
    450                 455                 460                 


Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu Ala Arg Glu 
465                 470                 475                 480 


Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys Glu Gln Asn 
                485                 490                 495     


Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys Glu Lys Leu 
            500                 505                 510         


Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg Leu Phe Lys 
        515                 520                 525             


Glu Gln Lys Glu Phe Cys Val Tyr Ser Gly Glu Lys Ile Lys Leu Ser 
    530                 535                 540                 


Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile Tyr Pro Tyr 
545                 550                 555                 560 


Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu Val Phe Thr 
                565                 570                 575     


Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu Ala Phe Gly 
            580                 585                 590         


Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala Lys Asn Leu 
        595                 600                 605             


Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr Lys Asp Lys 
    610                 615                 620                 


Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr Arg Tyr Ile 
625                 630                 635                 640 


Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp Phe Leu Pro 
                645                 650                 655     


Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln Lys Gly Ser 
            660                 665                 670         


Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser Ala Leu Arg 
        675                 680                 685             


His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His Leu His His 
    690                 695                 700                 


Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser Ile Val Lys 
705                 710                 715                 720 


Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Thr Ala Glu Leu 
                725                 730                 735     


Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys Arg Lys Phe 
            740                 745                 750         


Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp Lys Ile Asp 
        755                 760                 765             


Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser Gly Ala Leu 
    770                 775                 780                 


His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln Ser Tyr Gly 
785                 790                 795                 800 


Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys Ile Arg Lys 
                805                 810                 815     


Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg Val Asp Ile 
            820                 825                 830         


Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro Ile Tyr Thr 
        835                 840                 845             


Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val Ala Arg Ser 
    850                 855                 860                 


Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu Asn Tyr Glu 
865                 870                 875                 880 


Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile Gln Thr Lys 
                885                 890                 895     


Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe Thr Ser Ser 
            900                 905                 910         


Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe Glu Thr Leu 
        915                 920                 925             


Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu Lys Glu Val 
    930                 935                 940                 


Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe Glu Lys Tyr 
945                 950                 955                 960 


Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe Arg Gln Arg 
                965                 970                 975     


Glu Glu Phe Lys Asn Glu Leu Arg 
            980                 


<210> 115
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 110-21

<400> 115
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asn Ile Lys Asn Ser Asp Asn Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Leu Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Val Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Asn Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Leu Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Thr Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Ile Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Val Gln Gly Lys Asp Lys Lys Ser Gly Leu Ile Lys Asp Trp Ile Leu 
865                 870                 875                 880 


Met Asp Glu Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu 
                885                 890                 895     


Ile Leu Ile Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr 
            900                 905                 910         


Asn Ala Phe Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp 
        915                 920                 925             


Asn Lys Phe Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn 
    930                 935                 940                 


Ala Asn Glu Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu 
945                 950                 955                 960 


Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys 
                965                 970                 975     


Ala Glu Phe Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 985         


<210> 116
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 129-258

<400> 116
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asn Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Val Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Asn Glu Leu Arg 
            980                 985         


<210> 117
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 1336

<400> 117
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Gly Lys 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Ser Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Leu Leu Met Lys Lys Glu Arg Gln 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Ala Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asn Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Gln Lys Tyr Lys 
                325                 330                 335     


Glu Phe Val Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Val Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Thr Phe Gly Asn Asp Arg Val Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Thr Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Ala Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Thr 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Leu Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Met Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Val Gln Gly Lys Asp Lys Lys Ser Gly Leu Ile Lys Asp Trp Ile Leu 
865                 870                 875                 880 


Met Asp Glu Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu 
                885                 890                 895     


Ile Leu Ile Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Tyr 
            900                 905                 910         


Glu Arg Leu Asp Ser Ser Asn Ala Ser Leu Thr Val Ser Lys His Asp 
        915                 920                 925             


Asn Lys Phe Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn 
    930                 935                 940                 


Ala Asn Glu Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu 
945                 950                 955                 960 


Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys 
                965                 970                 975     


Ala Glu Phe Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 985         


<210> 118
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 140-16

<400> 118
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Ile Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 119
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 1577

<400> 119
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Val Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 120
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 1854

<400> 120
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ser Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Asn Glu Leu Arg 
            980                 985         


<210> 121
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 1997-10

<400> 121
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn Arg Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Asn Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Val Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val Tyr Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 122
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 2008-1025

<400> 122
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asn Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Val Gln Gly Lys Asp Lys Lys Ser Gly Leu Ile Lys Asp Trp Ile Leu 
865                 870                 875                 880 


Met Asp Glu Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu 
                885                 890                 895     


Ile Leu Ile Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe 
            900                 905                 910         


Asn Ala Phe Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp 
        915                 920                 925             


Asn Lys Phe Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn 
    930                 935                 940                 


Ala Asn Glu Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu 
945                 950                 955                 960 


Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys 
                965                 970                 975     


Ala Glu Phe Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 985         


<210> 123
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 2008-872

<400> 123
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 124
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 2008-979

<400> 124
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Glu Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Asn Glu Leu Arg 
            980                 985         


<210> 125
<211> 965
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 2008-988

<400> 125
Met Lys Ile Ile Gly Phe Asn Leu Gly Ile Ala Asn Ile Gly Trp Ala 
1               5                   10                  15      


Leu Arg Glu Asn Asp Glu Ile Ile Asp Cys Gly Val Arg Val Phe Asp 
            20                  25                  30          


Ile Pro Glu Asn Pro Lys Asn Gly Asn Ser Leu Ala Leu Glu Arg Arg 
        35                  40                  45              


Glu Asn Lys Ala Arg Met Lys Ile Val Lys Arg Lys Lys Ala Arg Met 
    50                  55                  60                  


Leu Ala Thr Lys Thr Phe Leu Lys Lys Glu Leu Asn Val Asp Leu Ser 
65                  70                  75                  80  


Lys Leu Phe Leu Ile Gly Ser Thr Gln Ser Ile Tyr Glu Leu Arg Ala 
                85                  90                  95      


Lys Ala Leu Ser Ser Leu Ile Ser Lys Glu Glu Leu Ser Ala Ile Ile 
            100                 105                 110         


Leu His Ile Ala Lys His Arg Gly Tyr Asp Asp Ser Ala Leu Lys Asn 
        115                 120                 125             


Glu Asn Gly Thr Ile Ile Glu Ala Leu Asn Lys Asn Lys Glu Thr Met 
    130                 135                 140                 


Leu Lys Phe Lys Ser Val Gly Glu Tyr Phe Tyr Lys Asn Phe Val Gln 
145                 150                 155                 160 


Asn Lys Glu Val Lys Lys Ile Arg Asn Thr Thr Glu Asp Tyr Ser Asn 
                165                 170                 175     


Ser Val Pro Arg Ser Leu Leu Lys Gln Glu Leu Asp Leu Ile Leu Asp 
            180                 185                 190         


Lys Gln Lys Glu Leu Gly Leu Ile Lys Asn Ala Asp Phe Lys Glu Lys 
        195                 200                 205             


Leu Phe Glu Ile Ile Phe Phe Lys Arg Pro Leu Lys Asp Phe Ser Asn 
    210                 215                 220                 


Lys Ile Gly Asn Cys Ile Phe Phe Glu Asn Glu Lys Arg Ala Ala Lys 
225                 230                 235                 240 


Asn Thr Ile Ser Ala Cys Glu Phe Val Ala Leu Gly Lys Val Val Asn 
                245                 250                 255     


Leu Leu Lys Ser Ile Glu Lys Asp Ile Gly Ile Val Tyr Glu Lys Asp 
            260                 265                 270         


Ser Ile Asn Glu Ile Met Ser Ile Ile Leu Asp Lys Thr Ser Ile Ser 
        275                 280                 285             


Tyr Lys Lys Ile Arg Asp Ile Leu Asn Leu Pro Gln Glu Ile Asn Phe 
    290                 295                 300                 


Lys Gly Leu Asp Tyr Ser Lys Asn Asn Val Glu Asn Ser Lys Leu Val 
305                 310                 315                 320 


Asp Leu Lys Lys Leu Asn Glu Phe Lys Lys Ala Leu Gly Asp Gly Phe 
                325                 330                 335     


Ala Asn Leu Asp Lys Asp Ile Leu Asp Ser Ile Ala Thr Asp Ile Thr 
            340                 345                 350         


Leu Thr Lys Asp Thr Ala Thr Leu Lys Glu Lys Leu Lys Asn Tyr Asn 
        355                 360                 365             


Val Leu Asn Ala Glu Gln Ile Glu Lys Leu Ser Glu Leu Val Phe Asn 
    370                 375                 380                 


Asp His Ile Asn Leu Ser Leu Lys Ala Leu Lys Gln Ile Ile Pro Leu 
385                 390                 395                 400 


Met Tyr Glu Gly Lys Arg Tyr Asp Glu Ala Cys Glu Leu Cys Asn Phe 
                405                 410                 415     


Thr Ile Ala Lys Asn Gln Glu Lys Ser Glu Tyr Leu Pro Leu Phe Glu 
            420                 425                 430         


Lys Thr Arg Phe Ala Lys Asp Ile Ser Ser Pro Val Val Ile Arg Ala 
        435                 440                 445             


Ile Cys Glu Phe Arg Lys Leu Leu Asn Asp Ile Ile Arg Arg Tyr Gly 
    450                 455                 460                 


Ser Val His Lys Ile His Leu Glu Leu Thr Arg Asp Phe Gly Ile Ser 
465                 470                 475                 480 


Phe Ser Asp Arg Lys Lys Ile Ile Lys Glu Ile Glu Gln Asn Glu Gln 
                485                 490                 495     


Ser Arg Ile Lys Ala Leu Glu Thr Ile Lys Glu Leu Lys Leu Glu Glu 
            500                 505                 510         


Thr Ser Lys Asn Ile Gln Ile Val Arg Leu Phe Glu Asp Gln Lys Gly 
        515                 520                 525             


Ile Cys Pro Tyr Ser Gly Leu Lys Met Asp Leu Asn Arg Leu Asp Glu 
    530                 535                 540                 


Leu Val Ile Asp Tyr Ile Arg Pro Tyr Asn Arg Ser Leu Asp Asp Ser 
545                 550                 555                 560 


Tyr Ser Asn Lys Val Leu Thr Phe Lys Lys Leu Ser Asp Leu Lys Gln 
                565                 570                 575     


Gly Lys Thr Pro Phe Glu Ala Phe Gly Glu Asp Glu Lys Leu Trp Ala 
            580                 585                 590         


Glu Ile Asn Glu Arg Ile Lys Glu Tyr Asn Gly Lys Lys Arg Phe Lys 
        595                 600                 605             


Ile Phe Asp Lys Phe Phe Lys Asp Lys Lys Pro Phe Asp Phe Thr Glu 
    610                 615                 620                 


Gln Thr Leu Gln Asp Thr Arg Trp Leu Thr Lys Leu Val Ala Ser Tyr 
625                 630                 635                 640 


Leu Asn Glu Tyr Leu Ser Phe Leu Pro Ile Ser Glu Asp Glu Asn Thr 
                645                 650                 655     


Ala Leu Gly Tyr Gly Glu Lys Gly Ser Lys Gln His Val Ile Leu Ser 
            660                 665                 670         


Ser Gly Met Ile Thr Gln Met Leu Arg Asn Phe Trp Tyr Leu Gly Phe 
        675                 680                 685             


Lys Asn His Lys Asp Tyr Lys Asn Asn Ala Met Asp Ala Ile Ile Val 
    690                 695                 700                 


Ala Phe Thr Thr Asn Ser Ile Ile Phe Ala Phe Asn Asn Phe Lys Lys 
705                 710                 715                 720 


Glu Leu Asp Leu Ala Lys Ala Glu Phe Tyr Ala Asn Lys Ile Ser Glu 
                725                 730                 735     


Ser Asp Tyr Leu Leu Lys Arg Lys Phe Leu Pro Pro Phe Ser Gly Phe 
            740                 745                 750         


Lys Glu Gln Ala Leu Glu Lys Val Lys Asn Ile Phe Val Ser His Ser 
        755                 760                 765             


Leu Lys Ile Lys Asn Lys Gly Thr Leu His Asp Leu Thr Pro Leu Lys 
    770                 775                 780                 


Ile Lys Glu Leu Lys Asn Thr Tyr Gly Asp Leu Asp Leu Ala Val Lys 
785                 790                 795                 800 


Leu Gly Lys Ile Arg Lys Tyr Asn Asp Lys Tyr Tyr Ala Asn Ala Asn 
                805                 810                 815     


Gly Ser Leu Val Arg Ala Asp Leu Phe Val Asp Lys Lys Asn Lys Phe 
            820                 825                 830         


His Ala Val Ser Ile Tyr Lys Ala Asp Phe Ser Thr Lys Lys Leu Pro 
        835                 840                 845             


Asn Lys Thr Pro Ala Thr Thr Ser Asn Gly Glu Thr Lys Glu Gly Ile 
    850                 855                 860                 


Glu Met Asn Glu Asn Tyr Asn Phe Cys Met Ser Leu Tyr Lys Asn Thr 
865                 870                 875                 880 


Pro Ile Ser Val Lys Ile Lys Gly Met Lys Glu Pro Ile Ile Cys Tyr 
                885                 890                 895     


Tyr His Gly Phe Asn Thr Ser Gly Ser Lys Ile Thr Tyr Lys Lys His 
            900                 905                 910         


Asp Asn Asn Tyr His Asn Leu Ser Glu Asp Glu Met Val Val Phe Arg 
        915                 920                 925             


Lys Asn Asp Lys Glu Ser Ile Ala Val Gly Lys Ile Leu Glu Ile Lys 
    930                 935                 940                 


Lys Tyr Ser Ile Ser Pro Ser Gly Glu Leu Ser Leu Ile Glu Asn Glu 
945                 950                 955                 960 


Glu Arg Lys Trp Phe 
                965 


<210> 126
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 2008-988

<400> 126
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Thr Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 127
<211> 961
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 260.94

<400> 127
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Gly Lys 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Thr Gln Ser Phe Leu Lys Tyr Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Ser Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Gly Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Leu Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Asn Val Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Glu Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Lys Gly Ser Lys 
            660                 665                 670         


Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser Ala Leu Arg His 
        675                 680                 685             


Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His Leu His His Ala 
    690                 695                 700                 


Ile Asp Ala Ala Ile Ile Ala Tyr Ala Asn Asn Ser Ile Val Lys Asp 
705                 710                 715                 720 


Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser Ala Glu Leu Tyr 
                725                 730                 735     


Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys Arg Lys Phe Phe 
            740                 745                 750         


Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp Lys Ile Asp Glu 
        755                 760                 765             


Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser Gly Ala Leu His 
    770                 775                 780                 


Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln Ser Tyr Gly Gly 
785                 790                 795                 800 


Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys Ile Arg Lys Val 
                805                 810                 815     


Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg Val Asp Ile Phe 
            820                 825                 830         


Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro Ile Tyr Thr Met 
        835                 840                 845             


Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val Ala Arg Ser Lys 
    850                 855                 860                 


Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu Asn Tyr Glu Phe 
865                 870                 875                 880 


Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile Gln Thr Lys Asp 
                885                 890                 895     


Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe Thr Ser Ser Thr 
            900                 905                 910         


Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe Glu Thr Leu Ser 
        915                 920                 925             


Lys Asn Leu Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu 
    930                 935                 940                 


Val Thr Lys Ala Glu Phe Arg Gln Arg Glu Asp Phe Lys Asn Glu Leu 
945                 950                 955                 960 


Arg 
    


<210> 128
<211> 985
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 414

<400> 128
Met Ala Lys Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Val Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Thr Leu Ile Ser Pro Tyr Glu Leu Arg Phe Lys Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Leu Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asn Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Val Lys Glu Asn Glu Glu Lys Leu Ala Asn Tyr Lys 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Asn Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Val Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Glu Phe Val Ala Leu Thr Arg Ile Val 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Asn Lys Asn Asn Ser Tyr Ile Lys Asp Asp 
        275                 280                 285             


Leu Asn Ala Leu Leu Ser Glu Val Leu Lys Asn Gly Thr Leu Thr Tyr 
    290                 295                 300                 


Lys Gln Thr Lys Lys Ile Leu Gly Leu Ser Asp Asp Tyr Glu Phe Lys 
305                 310                 315                 320 


Gly Gln Lys Gly Asn Tyr Phe Ile Glu Phe Lys Lys Tyr Lys Glu Phe 
                325                 330                 335     


Ile Lys Ala Leu Cys Glu His Asn Leu Asn Gln Asp Asp Leu Asn Glu 
            340                 345                 350         


Ile Ala Lys Asp Ile Thr Leu Val Lys Asp Glu Thr Lys Leu Lys Lys 
        355                 360                 365             


Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Glu Asn Leu Ser 
    370                 375                 380                 


Lys Ile Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala Leu Lys 
385                 390                 395                 400 


Leu Ile Val Pro Leu Met Arg Glu Gly Lys Lys Tyr Asp Glu Val Cys 
                405                 410                 415     


Asn Glu Leu Asn Leu Lys Thr Ala Ile Asn Glu Asp Lys Lys Glu Phe 
            420                 425                 430         


Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Asn Asn Pro 
        435                 440                 445             


Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn Ser Leu 
    450                 455                 460                 


Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Val Gly Lys Asn His Arg Glu Arg Ser Lys Ile Glu Lys Glu Gln 
                485                 490                 495     


Asn Glu Asn Phe Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys Glu Lys 
            500                 505                 510         


Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg Leu Phe 
        515                 520                 525             


Lys Glu Gln Lys Glu Phe Cys Val Tyr Ser Gly Glu Lys Ile Lys Ile 
    530                 535                 540                 


Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile Tyr Pro 
545                 550                 555                 560 


Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu Val Phe 
                565                 570                 575     


Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu Ala Phe 
            580                 585                 590         


Gly Lys Asp Asp Val Lys Trp Gln Lys Ile Glu Thr Leu Ala Lys Asn 
        595                 600                 605             


Leu Pro Ala Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr Lys Asp 
    610                 615                 620                 


Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr Arg Tyr 
625                 630                 635                 640 


Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Glu Phe Leu 
                645                 650                 655     


Pro Leu Ser Asp Asp Glu Asn Ile Lys Leu Asn Asp Thr Gln Lys Gly 
            660                 665                 670         


Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser Val Leu 
        675                 680                 685             


Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His Leu His 
    690                 695                 700                 


His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Ala Ser Val Val 
705                 710                 715                 720 


Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Asn Tyr Thr Ala Glu 
                725                 730                 735     


Leu Tyr Ala Lys Lys Ile Asn Glu Leu Asp Phe Lys Asn Lys Arg Lys 
            740                 745                 750         


Phe Phe Glu Pro Phe Ser Asn Phe Arg Gln Lys Val Leu Glu Lys Ile 
        755                 760                 765             


Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser Gly Ala 
    770                 775                 780                 


Leu His Glu Glu Thr Phe Tyr Lys Glu Glu Glu Phe Tyr Lys Glu Tyr 
785                 790                 795                 800 


Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys Ile Arg 
                805                 810                 815     


Lys Val Asn Gly Lys Ile Val Ser Asn Ala Asn Met Phe Arg Val Asp 
            820                 825                 830         


Ile Phe Lys Tyr Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro Ile Tyr 
        835                 840                 845             


Thr Met Asp Phe Ala Leu Gly Ile Leu Pro Asn Lys Ala Val Val Gly 
    850                 855                 860                 


Gly Lys Asp Lys Gln Gly Ile Ile Lys Asp Trp Leu Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Leu 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Lys Ser Phe 
            900                 905                 910         


Lys Ser Ser Thr Ala Gly Leu Val Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Asn Leu Asn Glu Asn Gln Lys Lys Leu Phe Lys Ser Ala Asn Glu 
    930                 935                 940                 


Lys Lys Val Val Ala Glu Gly Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Ile Thr Lys Ala Glu Ile 
                965                 970                 975     


Lys Glu Arg Glu Asn Phe Lys Lys Lys 
            980                 985 


<210> 129
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 51037

<400> 129
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Val Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Thr 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 130
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 51494

<400> 130
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Thr Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Glu Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Leu Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 131
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 53161

<400> 131
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Gly Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asn Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Val Gln Gly Lys Asp Lys Lys Ser Gly Leu Ile Lys Asp Trp Ile Leu 
865                 870                 875                 880 


Met Asp Glu Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu 
                885                 890                 895     


Ile Leu Ile Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe 
            900                 905                 910         


Asn Ala Phe Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp 
        915                 920                 925             


Asn Lys Phe Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn 
    930                 935                 940                 


Ala Asn Glu Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu 
945                 950                 955                 960 


Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys 
                965                 970                 975     


Ala Glu Phe Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 985         


<210> 132
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 60004

<400> 132
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Gly Lys 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Thr Gln Ser Phe Leu Lys Tyr Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Ile Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Ile Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Ile Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 133
<211> 984
<212> PRT
<213> Campylobacter jejuni

<400> 133
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Thr Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Ile Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Ile Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Ile Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Leu Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Thr Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Glu Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Ala Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Val Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 134
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 84-25

<400> 134
Met Val Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 135
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 87459

<400> 135
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Phe Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 136
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni ATCC 33560

<400> 136
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Thr Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 137
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni CF93-6

<400> 137
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Val Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Gly Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Asn Glu Leu Arg 
            980                 985         


<210> 138
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni CG8486

<400> 138
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 139
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni HB93-13

<400> 139
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Leu Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 140
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni LMG 23210

<400> 140
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Val Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Asn Glu Leu Arg 
            980                 985         


<210> 141
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni LMG 23211

<400> 141
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Thr Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Asp Glu His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Ile Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Ile Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Gly Val Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Glu Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Ala Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Val Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 142
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni LMG 23263

<400> 142
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Val Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Phe Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 143
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni LMG 23264

<400> 143
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asn Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 144
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni LMG 23269

<400> 144
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asn Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe His Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Val Gln Gly Lys Asp Lys Lys Ser Gly Leu Ile Lys Asp Trp Ile Leu 
865                 870                 875                 880 


Met Asp Glu Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu 
                885                 890                 895     


Ile Leu Ile Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe 
            900                 905                 910         


Asn Ala Phe Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp 
        915                 920                 925             


Asn Lys Phe Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn 
    930                 935                 940                 


Ala Asn Glu Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu 
945                 950                 955                 960 


Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys 
                965                 970                 975     


Ala Glu Phe Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 985         


<210> 145
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni LMG 23357

<400> 145
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Cys Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Gly Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Ser Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Lys Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asn Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Gln Lys Tyr Lys 
                325                 330                 335     


Glu Phe Val Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Val Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Thr Phe Gly Asn Asp Arg Val Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Thr Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Ala Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Thr 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Leu Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Ser Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Val Gln Gly Lys Asp Lys Lys Ser Gly Leu Ile Lys Asp Trp Ile Leu 
865                 870                 875                 880 


Met Asp Glu Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu 
                885                 890                 895     


Ile Leu Ile Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Tyr 
            900                 905                 910         


Glu Arg Leu Asp Ser Ser Asn Ala Ser Leu Thr Val Ser Lys His Asp 
        915                 920                 925             


Asn Lys Phe Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn 
    930                 935                 940                 


Ala Asn Glu Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu 
945                 950                 955                 960 


Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys 
                965                 970                 975     


Ala Glu Phe Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 985         


<210> 146
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

<400> 146
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Val Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 147
<211> 983
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni NW

<400> 147
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Val Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Phe Tyr Gln Ser 
785                 790                 795                 800 


Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys Ile 
                805                 810                 815     


Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg Val 
            820                 825                 830         


Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro Ile 
        835                 840                 845             


Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val Ala 
    850                 855                 860                 


Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu Asn 
865                 870                 875                 880 


Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile Gln 
                885                 890                 895     


Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe Thr 
            900                 905                 910         


Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe Glu 
        915                 920                 925             


Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu Lys 
    930                 935                 940                 


Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe Glu 
945                 950                 955                 960 


Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe Arg 
                965                 970                 975     


Gln Arg Glu Asp Phe Lys Lys 
            980             


<210> 148
<211> 987
<212> PRT
<213> Campylobacter jejuni

<400> 148
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asn Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Pro Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Val Gln Gly Lys Asp Lys Lys Ser Gly Leu Ile Lys Asp Trp Ile Leu 
865                 870                 875                 880 


Met Asp Glu Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu 
                885                 890                 895     


Ile Leu Ile Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe 
            900                 905                 910         


Asn Ala Phe Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp 
        915                 920                 925             


Asn Lys Phe Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn 
    930                 935                 940                 


Ala Asn Glu Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu 
945                 950                 955                 960 


Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys 
                965                 970                 975     


Ala Glu Phe Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 985         


<210> 149
<211> 1003
<212> PRT
<213> Campylobacter lari

<400> 149
Met Arg Ile Leu Gly Phe Asp Ile Gly Ile Asn Ser Ile Gly Trp Ala 
1               5                   10                  15      


Phe Val Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe Thr 
            20                  25                  30          


Lys Ala Glu Asn Pro Lys Asn Lys Glu Ser Leu Ala Leu Pro Arg Arg 
        35                  40                  45              


Asn Ala Arg Ser Ser Arg Arg Arg Leu Lys Arg Arg Lys Ala Arg Leu 
    50                  55                  60                  


Ile Ala Ile Lys Arg Ile Leu Ala Lys Glu Leu Lys Leu Asn Tyr Lys 
65                  70                  75                  80  


Asp Tyr Val Ala Ala Asp Gly Glu Leu Pro Lys Ala Tyr Glu Gly Ser 
                85                  90                  95      


Leu Ala Ser Val Tyr Glu Leu Arg Tyr Lys Ala Leu Thr Gln Asn Leu 
            100                 105                 110         


Glu Thr Lys Asp Leu Ala Arg Val Ile Leu His Ile Ala Lys His Arg 
        115                 120                 125             


Gly Tyr Met Asn Lys Asn Glu Lys Lys Ser Asn Asp Ala Lys Lys Gly 
    130                 135                 140                 


Lys Ile Leu Ser Ala Leu Lys Asn Asn Ala Leu Lys Leu Glu Asn Tyr 
145                 150                 155                 160 


Gln Ser Val Gly Glu Tyr Phe Tyr Lys Glu Phe Phe Gln Lys Tyr Lys 
                165                 170                 175     


Lys Asn Thr Lys Asn Phe Ile Lys Ile Arg Asn Thr Lys Asp Asn Tyr 
            180                 185                 190         


Asn Asn Cys Val Leu Ser Ser Asp Leu Glu Lys Glu Leu Lys Leu Ile 
        195                 200                 205             


Leu Glu Lys Gln Lys Glu Phe Gly Tyr Asn Tyr Ser Glu Asp Phe Ile 
    210                 215                 220                 


Asn Glu Ile Leu Lys Val Ala Phe Phe Gln Arg Pro Leu Lys Asp Phe 
225                 230                 235                 240 


Ser His Leu Val Gly Ala Cys Thr Phe Phe Glu Glu Glu Lys Arg Ala 
                245                 250                 255     


Cys Lys Asn Ser Tyr Ser Ala Trp Glu Phe Val Ala Leu Thr Lys Ile 
            260                 265                 270         


Ile Asn Glu Ile Lys Ser Leu Glu Lys Ile Ser Gly Glu Ile Val Pro 
        275                 280                 285             


Thr Gln Thr Ile Asn Glu Val Leu Asn Leu Ile Leu Asp Lys Gly Ser 
    290                 295                 300                 


Ile Thr Tyr Lys Lys Phe Arg Ser Cys Ile Asn Leu His Glu Ser Ile 
305                 310                 315                 320 


Ser Phe Lys Ser Leu Lys Tyr Asp Lys Glu Asn Ala Glu Asn Ala Lys 
                325                 330                 335     


Leu Ile Asp Phe Arg Lys Leu Val Glu Phe Lys Lys Ala Leu Gly Val 
            340                 345                 350         


His Ser Leu Ser Arg Gln Glu Leu Asp Gln Ile Ser Thr His Ile Thr 
        355                 360                 365             


Leu Ile Lys Asp Asn Val Lys Leu Lys Thr Val Leu Glu Lys Tyr Asn 
    370                 375                 380                 


Leu Ser Asn Glu Gln Ile Asn Asn Leu Leu Glu Ile Glu Phe Asn Asp 
385                 390                 395                 400 


Tyr Ile Asn Leu Ser Phe Lys Ala Leu Gly Met Ile Leu Pro Leu Met 
                405                 410                 415     


Arg Glu Gly Lys Arg Tyr Asp Glu Ala Cys Glu Ile Ala Asn Leu Lys 
            420                 425                 430         


Pro Lys Thr Val Asp Glu Lys Lys Asp Phe Leu Pro Ala Phe Cys Asp 
        435                 440                 445             


Ser Ile Phe Ala His Glu Leu Ser Asn Pro Val Val Asn Arg Ala Ile 
    450                 455                 460                 


Ser Glu Tyr Arg Lys Val Leu Asn Ala Leu Leu Lys Lys Tyr Gly Lys 
465                 470                 475                 480 


Val His Lys Ile His Leu Glu Leu Ala Arg Asp Val Gly Leu Ser Lys 
                485                 490                 495     


Lys Ala Arg Glu Lys Ile Glu Lys Glu Gln Lys Glu Asn Gln Ala Val 
            500                 505                 510         


Asn Ala Trp Ala Leu Lys Glu Cys Glu Asn Ile Gly Leu Lys Ala Ser 
        515                 520                 525             


Ala Lys Asn Ile Leu Lys Leu Lys Leu Trp Lys Glu Gln Lys Glu Ile 
    530                 535                 540                 


Cys Ile Tyr Ser Gly Asn Lys Ile Ser Ile Glu His Leu Lys Asp Glu 
545                 550                 555                 560 


Lys Ala Leu Glu Val Asp His Ile Tyr Pro Tyr Ser Arg Ser Phe Asp 
                565                 570                 575     


Asp Ser Phe Ile Asn Lys Val Leu Val Phe Thr Lys Glu Asn Gln Glu 
            580                 585                 590         


Lys Leu Asn Lys Thr Pro Phe Glu Ala Phe Gly Lys Asn Ile Glu Lys 
        595                 600                 605             


Trp Ser Lys Ile Gln Thr Leu Ala Gln Asn Leu Pro Tyr Lys Lys Lys 
    610                 615                 620                 


Asn Lys Ile Leu Asp Glu Asn Phe Lys Asp Lys Gln Gln Glu Asp Phe 
625                 630                 635                 640 


Ile Ser Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Thr Leu Ile Ala 
                645                 650                 655     


Lys Tyr Thr Lys Glu Tyr Leu Asn Phe Leu Leu Leu Ser Glu Asn Glu 
            660                 665                 670         


Asn Ala Asn Leu Lys Ser Gly Glu Lys Gly Ser Lys Ile His Val Gln 
        675                 680                 685             


Thr Ile Ser Gly Met Leu Thr Ser Val Leu Arg His Thr Trp Gly Phe 
    690                 695                 700                 


Asp Lys Lys Asp Arg Asn Asn His Leu His His Ala Leu Asp Ala Ile 
705                 710                 715                 720 


Ile Val Ala Tyr Ser Thr Asn Ser Ile Ile Lys Ala Phe Ser Asp Phe 
                725                 730                 735     


Arg Lys Asn Gln Glu Leu Leu Lys Ala Arg Phe Tyr Ala Lys Glu Leu 
            740                 745                 750         


Thr Ser Asp Asn Tyr Lys His Gln Val Lys Phe Phe Glu Pro Phe Lys 
        755                 760                 765             


Ser Phe Arg Glu Lys Ile Leu Ser Lys Ile Asp Glu Ile Phe Val Ser 
    770                 775                 780                 


Lys Pro Pro Arg Lys Arg Ala Arg Arg Ala Leu His Lys Asp Thr Phe 
785                 790                 795                 800 


His Ser Glu Asn Lys Ile Ile Asp Lys Cys Ser Tyr Asn Ser Lys Glu 
                805                 810                 815     


Gly Leu Gln Ile Ala Leu Ser Cys Gly Arg Val Arg Lys Ile Gly Thr 
            820                 825                 830         


Lys Tyr Val Glu Asn Asp Thr Ile Val Arg Val Asp Ile Phe Lys Lys 
        835                 840                 845             


Gln Asn Lys Phe Tyr Ala Ile Pro Ile Tyr Ala Met Asp Phe Ala Leu 
    850                 855                 860                 


Gly Ile Leu Pro Asn Lys Ile Val Ile Thr Gly Lys Asp Lys Asn Asn 
865                 870                 875                 880 


Asn Pro Lys Gln Trp Gln Thr Ile Asp Glu Ser Tyr Glu Phe Cys Phe 
                885                 890                 895     


Ser Leu Tyr Lys Asn Asp Leu Ile Leu Leu Gln Lys Lys Asn Met Gln 
            900                 905                 910         


Glu Pro Glu Phe Ala Tyr Tyr Asn Asp Phe Ser Ile Ser Thr Ser Ser 
        915                 920                 925             


Ile Cys Val Glu Lys His Asp Asn Lys Phe Glu Asn Leu Thr Ser Asn 
    930                 935                 940                 


Gln Lys Leu Leu Phe Ser Asn Ala Lys Glu Gly Ser Val Lys Val Glu 
945                 950                 955                 960 


Ser Leu Gly Ile Gln Asn Leu Lys Val Phe Glu Lys Tyr Ile Ile Thr 
                965                 970                 975     


Pro Leu Gly Asp Lys Ile Lys Ala Asp Phe Gln Pro Arg Glu Asn Ile 
            980                 985                 990         


Ser Leu Lys Thr Ser Lys Lys Tyr  Gly Leu Arg 
        995                 1000             


<210> 150
<211> 1430
<212> PRT
<213> Capnocytophaga canimorsus

<400> 150
Met Lys His Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Val Lys Glu Ala Gln Asn Asp Asn Glu Gln Ser Glu Ile Val 
            20                  25                  30          


Asp Val Gly Val Arg Val Asn Pro Leu Thr Thr Asp Glu Lys Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Pro Ile Ser Thr Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Ser Ala Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Lys Glu 
65                  70                  75                  80  


Leu Ile Glu Leu Leu Lys Glu His Gln Leu Ile Ser Thr Asp Thr Ile 
                85                  90                  95      


Leu Thr Glu Asn Gly Lys Gly Thr Thr Phe Gln Thr Leu Glu Leu Arg 
            100                 105                 110         


Ala Lys Ser Ala Lys Glu Lys Ile Ser Leu Glu Glu Leu Ala Arg Val 
        115                 120                 125             


Phe Leu Thr Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Asn Glu Asp Glu Gly Gln Leu Ile Asp Gly Met Glu Ile Ala Lys 
145                 150                 155                 160 


Arg Leu Tyr Glu Glu Asn Leu Thr Thr Gly Gln Leu Ser Leu Gln Leu 
                165                 170                 175     


Leu Lys Glu Gly Lys Lys Ser Leu Pro Asp Tyr Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Phe Glu Leu Asp Lys Val Trp Asn Phe Gln Lys Gln Phe His Ser 
        195                 200                 205             


His Ile Leu Thr Asp Glu Phe Tyr Ala Gln Leu Lys Gly Lys Gly Gln 
    210                 215                 220                 


Arg Ala Thr Ser Ala Leu Phe Leu Ala Lys Tyr Gln Ile Tyr Thr Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Ser Arg Glu Asp Lys Lys Leu Gln Ala Tyr Gln Trp 
                245                 250                 255     


Arg Val Asp Ala Leu Ser Lys Glu Leu Thr Arg Glu Gln Leu Ala Phe 
            260                 265                 270         


Val Ile Thr Glu Ile Asn Asn Asn Leu Asn Asn Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Asn Glu Thr 
    290                 295                 300                 


Val Gly Glu Tyr Leu Trp Lys Gln Ile Ala Ala Asn Pro His Thr Ser 
305                 310                 315                 320 


Leu Lys Asn Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Gln Ile Trp Lys Thr Gln Ser Ala Phe Tyr Pro Glu Ile Leu Thr Asp 
            340                 345                 350         


Glu Leu Lys Lys Glu Leu Arg Asp Val Val Ile Phe Tyr Gln Arg Lys 
        355                 360                 365             


Leu Lys Ser Gln Lys Ser Leu Val Ser Phe Cys Glu Phe Glu Asn Lys 
    370                 375                 380                 


Glu Ile Glu Ile Lys Lys Glu Asp Gly Thr Ser Thr Lys Lys Val Ile 
385                 390                 395                 400 


Gly Leu Lys Val Ala Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys 
                405                 410                 415     


Ile Trp Gln Asn Leu Asn Asn Val Leu Ile Arg Lys Lys Gly Ser Lys 
            420                 425                 430         


Thr Lys Lys Val Asp Lys Asn Gln Gln Ala Val Leu Phe Glu Glu Glu 
        435                 440                 445             


Lys Thr Ile Phe Glu Leu Asp Leu Glu Ala Lys Gln Ala Leu Phe Asn 
    450                 455                 460                 


Glu Leu Asn Leu Lys Gly Asn Leu Lys Ala Tyr Tyr Cys Leu Glu Ile 
465                 470                 475                 480 


Leu Gly Tyr Ser Pro Lys Glu Trp Glu Met Asn Tyr Ser Val Leu Glu 
                485                 490                 495     


Gly Asn Arg Thr Asn Lys Ala Leu Tyr Glu Ala Tyr Leu Lys Ile Thr 
            500                 505                 510         


Asp Leu Glu Gly Tyr Asp Ala Lys Asn His Leu Lys Val Lys Leu Asn 
        515                 520                 525             


Lys Asp Glu Val Glu Leu Asp Asp Leu Lys Val Pro Ala Ser Glu Ile 
    530                 535                 540                 


Lys Asp Met Val Gln Ala Ile Phe Lys Glu Ala Gly Ile Asn Thr Asp 
545                 550                 555                 560 


Ile Leu His Phe Asn Ala Glu Leu Asp Gly Lys Asp Phe Glu Asn Gln 
                565                 570                 575     


Ala Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser Tyr Glu Gly Asp Asp 
            580                 585                 590         


Ser Lys Ser Gly Asn Glu Leu Leu Tyr Lys Leu Leu Glu Thr Lys Phe 
        595                 600                 605             


Gly Phe Lys Lys Glu Tyr Ala Gln Ile Leu Ala Asn Val Ser Leu Ser 
    610                 615                 620                 


Asp Asp Tyr Gly Ser Leu Ser Thr Lys Ala Met Arg Lys Ile His Pro 
625                 630                 635                 640 


Tyr Ile Lys Glu Asn Lys Phe Ser Thr Ala Cys Glu Leu Ala Gly Tyr 
                645                 650                 655     


Arg His Ser Lys His Ser Leu Thr Lys Glu Glu Asn Asp Asn Arg Val 
            660                 665                 670         


Leu Lys Asp Ser Leu Glu Val Leu Lys Lys Asn Ser Leu Arg Gln Pro 
        675                 680                 685             


Val Val Glu Lys Ile Leu Asn Gln Met Ile Asn Leu Val Asn Ala Leu 
    690                 695                 700                 


Leu Lys Lys Tyr Arg Thr Glu Asn Pro Asn Phe Lys Phe Asp Glu Ile 
705                 710                 715                 720 


Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn Ala Glu Glu Arg Ala 
                725                 730                 735     


Asn Met Thr Val Asn Ile Asn Lys Ala Lys Thr Glu His Glu Lys Ile 
            740                 745                 750         


Ile Lys Ile Leu Lys Asn Glu Phe Gly Leu Pro Asn Pro Thr Arg Asn 
        755                 760                 765             


Asp Ile Ile Arg Tyr Arg Leu Tyr Glu Glu Leu Lys Ala Asn Gly Tyr 
    770                 775                 780                 


Lys Asp Leu Tyr Thr Asn Glu Tyr Ile Glu Lys Gln Asp Leu Phe Thr 
785                 790                 795                 800 


Lys Asn Ile Asp Ile Glu His Ile Ile Pro Lys Ser Arg Val Phe Asp 
                805                 810                 815     


Asp Ser Phe Ser Asn Lys Thr Leu Ser Phe Arg Lys Thr Asn Leu Asp 
            820                 825                 830         


Lys Gly Glu Arg Thr Ala Phe Asp Tyr Ile Glu Ser Lys Phe Gly Ala 
        835                 840                 845             


Asp Lys Leu Glu Glu Tyr Val Ala Arg Val Glu Asp Leu Tyr Lys Asn 
    850                 855                 860                 


Asn Ile Ile Ser Lys Ala Lys Tyr Gln Lys Leu Leu Lys Lys Glu Ser 
865                 870                 875                 880 


Glu Ile Gly Asp Gly Phe Val Glu Arg Asp Leu Arg Glu Thr Gln Tyr 
                885                 890                 895     


Ile Ala Lys Lys Ala Lys Glu Ile Leu Leu Gln Ile Thr Pro Asn Val 
            900                 905                 910         


Leu Ser Thr Ser Gly Gly Ile Thr Asp Arg Leu Arg Glu Asp Trp Asp 
        915                 920                 925             


Leu Ile Asn Val Met Lys Glu Leu Asn Leu Pro Lys Tyr Arg Ala Leu 
    930                 935                 940                 


Gly Leu Thr Gln Met Glu Asp Arg Lys Tyr Gly Gln Gln Val Glu Val 
945                 950                 955                 960 


Ile Ile Asp Trp Thr Lys Arg Asn Asp His Arg His His Ala Met Asp 
                965                 970                 975     


Ala Leu Thr Val Ala Phe Thr Lys His Asn His Ile Gln Tyr Leu Asn 
            980                 985                 990         


Tyr Leu Asn Ala Arg Lys Asn Glu  Lys His Arg Glu His  Ser Asn Ile 
        995                 1000                 1005             


Met Gly  Ile Gln Gln Leu Glu  Thr Ile Lys Val Thr  Asp Lys Asn 
    1010                 1015                 1020             


Gly Asn  Glu Lys Arg Val Phe  Lys Ala Pro Met Pro  Asn Phe Arg 
    1025                 1030                 1035             


Gln Val  Thr Lys Ala Phe Leu  Glu Asn Val Leu Ile  Ser His Lys 
    1040                 1045                 1050             


Ala Lys  Asn Lys Val Val Thr  Lys Asn Lys Asn Lys  Val Ala Gly 
    1055                 1060                 1065             


Ser Asn  Lys Val Gln Glu Val  Leu Thr Pro Arg Gly  Gln Leu His 
    1070                 1075                 1080             


Lys Glu  Thr Val Tyr Gly Lys  Tyr Gln Tyr Tyr Val  Gln Lys Glu 
    1085                 1090                 1095             


Glu Lys  Ile Gly Gly Lys Phe  Asp Leu Glu Thr Ile  Lys Lys Val 
    1100                 1105                 1110             


Ala Asn  Pro Leu Tyr Gln Ser  Leu Leu Lys Lys Arg  Leu Glu Glu 
    1115                 1120                 1125             


Asn Gly  Gly Asp Pro Lys Lys  Ala Phe Thr Gly Lys  Asn Ser Leu 
    1130                 1135                 1140             


Ala Lys  Asn Pro Ile Tyr Leu  Asp Asp Ala Gln Thr  Glu Gln Leu 
    1145                 1150                 1155             


Pro Glu  Lys Val Lys Leu Val  Trp Leu Glu Asn Ser  Phe Ser Ile 
    1160                 1165                 1170             


Arg Lys  Asp Ile Thr Pro Glu  Asn Phe Lys Asp Glu  Lys Leu Ile 
    1175                 1180                 1185             


Asp Lys  Ile Leu Asp Glu Gly  Val Lys Arg Ile Leu  Lys Glu Arg 
    1190                 1195                 1200             


Leu Gln  Ser Phe Gly Asn Asp  Ala Lys Lys Ala Phe  Ser Asp Leu 
    1205                 1210                 1215             


Asp Lys  Asn Pro Ile Trp Leu  Asn Lys Glu Lys Gly  Ile Ala Ile 
    1220                 1225                 1230             


Lys Arg  Val Ala Ile Ser Gly  Val Ala Asn Ala Glu  Pro Leu His 
    1235                 1240                 1245             


Thr Lys  Lys Asp His Leu Gly  Lys Glu Ile Leu Asp  Lys Glu Gly 
    1250                 1255                 1260             


Lys Ser  Ile Pro Val Asp Phe  Ile Ser Thr Gly Asn  Asn His His 
    1265                 1270                 1275             


Val Ala  Val Tyr Arg Asp Glu  Lys Gly Asn Leu Gln  Glu Lys Val 
    1280                 1285                 1290             


Val Ser  Val Phe Glu Ala Val  Val Arg Ala Asn Gln  Gly Leu Pro 
    1295                 1300                 1305             


Ile Ile  Asp Lys Thr Tyr Asn  Gln His Leu Gly Trp  Glu Phe Leu 
    1310                 1315                 1320             


Phe Thr  Met Lys Gln Asn Glu  Met Phe Val Phe Ser  Asn Glu Ser 
    1325                 1330                 1335             


Thr Gly  Phe Asn Pro Asn Asp  Ile Asp Leu Leu Asp  Pro Lys Asn 
    1340                 1345                 1350             


Lys Lys  Ile Ile Ser Pro Asn  Leu Phe Arg Val Gln  Lys Phe Ser 
    1355                 1360                 1365             


Lys Leu  Gln Tyr Gly Asn Ser  Phe Val Arg Glu Phe  Val Phe Arg 
    1370                 1375                 1380             


His His  Leu Glu Thr Thr Val  Glu Asp Arg Lys Glu  Leu Gln Gly 
    1385                 1390                 1395             


Ile Thr  Tyr Lys Gln Met Lys  Asn Ser Ala Phe Phe  Asn Asp Ile 
    1400                 1405                 1410             


Ile Lys  Val Arg Ile Asn His  Leu Gly Gly Ile Val  Ser Val Gly 
    1415                 1420                 1425             


Glu Tyr  
    1430 


<210> 151
<211> 1436
<212> PRT
<213> Capnocytophaga gingivalis


<220>
<223> Capnocytophaga gingivalis ATCC 33624

<400> 151
Met Lys Tyr Ile Lys Tyr Ile Leu Gly Leu Asp Ile Gly Ser Asn Ser 
1               5                   10                  15      


Ile Gly Trp Ala Leu Ile Gln Leu Asp Leu Leu Gln Lys Thr Lys Arg 
            20                  25                  30          


Ile Ile Ala Ala Gly Ser Arg Ile Ile Pro Met Asp Gln Lys Val Leu 
        35                  40                  45              


Ser Asp Phe Gly Lys Gly Ile Thr Ile Ser Pro Thr Ala Gln Arg Thr 
    50                  55                  60                  


Ser Tyr Arg Asn Ala Arg His Cys Arg Glu Arg His Leu Leu Arg Arg 
65                  70                  75                  80  


Glu Arg Leu His Arg Val Leu His Ile Leu Gly Phe Leu Pro Thr His 
                85                  90                  95      


Tyr Asp Lys Gln Ile Asp Phe Ser Lys Arg Tyr Gly Lys Phe Val Asp 
            100                 105                 110         


Asn Thr Glu Pro Lys Ile Ala Tyr Asn Glu Gly Lys Phe Leu Phe Met 
        115                 120                 125             


Asp Ser Phe Gln Glu Met Leu Ser Asp Phe Lys Ser His Gln Pro Asp 
    130                 135                 140                 


Leu Phe Tyr Thr Lys Lys Asn Gly Glu Glu Ser Lys Ile Pro Tyr Asp 
145                 150                 155                 160 


Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Gln Lys Ile Ser 
                165                 170                 175     


Lys Glu Glu Leu Ala Trp Ile Ile Leu Asn Phe Asn Gln Lys Arg Gly 
            180                 185                 190         


Tyr Tyr Gln Leu Arg Glu Glu Glu Gly Asn Lys Glu Asn Asp Phe Glu 
        195                 200                 205             


Ile Ile Ser Ser Lys Ile Ile Ser Val Ile Lys Lys Asp Lys Asp Lys 
    210                 215                 220                 


Lys Tyr Asn Lys Tyr Trp Tyr Asp Ile Ile Leu Glu Asn Gly Leu Val 
225                 230                 235                 240 


Tyr Gln Ala Ala Phe Tyr Asn Asp Phe Val Tyr Asn Trp Ile Asn Gln 
                245                 250                 255     


Asp Arg Glu Phe Ile Ile Glu Arg Thr Ser Leu Lys Asn Gly Ala Glu 
            260                 265                 270         


Lys Val Lys Leu Ser Tyr Leu Pro Thr Phe Asp Glu Ile Asp Lys Met 
        275                 280                 285             


Asp Lys Lys Glu Gln Asp Lys Tyr Tyr Lys Lys Ile Lys Ile Lys Thr 
    290                 295                 300                 


Glu Asn Ser Ile Gly Asn Lys Thr Val Gly Cys Tyr Ile Tyr Asp His 
305                 310                 315                 320 


Ile Leu Gln Asn Pro Asn Glu Lys Ile Lys Gly Lys Leu Val Arg Thr 
                325                 330                 335     


Ile Glu Arg Lys Tyr Tyr Lys Glu Glu Leu Lys Ala Ile Leu Glu Lys 
            340                 345                 350         


Gln Ile Ala Leu Gln Pro Glu Leu Phe Thr Asp Gln Leu Leu Ala Asp 
        355                 360                 365             


Cys Ile Arg Glu Leu Tyr Ser Lys Asn Glu Ala Gln Gln Arg Asn Leu 
    370                 375                 380                 


Ala Ala Arg Asp Phe Val His Leu Leu Val Glu Asp Ile Ile Phe Tyr 
385                 390                 395                 400 


Gln Arg Pro Leu Arg Arg Gln Lys Ser Thr Leu Ala Asn Cys Ser Leu 
                405                 410                 415     


Glu Ser Arg Ser Tyr Ile Asp Lys Asp Ser His Thr Arg Lys Glu Ala 
            420                 425                 430         


Pro Leu Lys Val Cys Pro Lys Ser Asn Pro Tyr Tyr Gln Glu Phe Arg 
        435                 440                 445             


Val Leu Gln Trp Leu Gln Asn Leu Lys Ile Tyr Glu Ile Asp Ser Asp 
    450                 455                 460                 


Gln Glu Val Thr His Gln Phe Ile Lys Thr Leu Glu Asp Lys Gln Gln 
465                 470                 475                 480 


Leu Phe Glu Phe Leu Met Ala Gln Lys Glu Ile Asp Cys Glu Glu Leu 
                485                 490                 495     


Leu Lys Tyr Phe Leu Asn Gln Thr Tyr Pro Asn Ala Lys Glu Lys Ala 
            500                 505                 510         


Leu Lys Ser Glu Leu Lys Lys Trp Lys Asp Thr Tyr Arg Trp Asn Tyr 
        515                 520                 525             


Val Tyr Asp Ile Gly Glu Lys Ser Ser Lys Lys Tyr Pro Met Asn Glu 
    530                 535                 540                 


Thr Arg Tyr Glu Leu Lys Arg His Leu Glu Lys Val Ala Asn Leu Pro 
545                 550                 555                 560 


Asp Asp Phe Leu Ser Ser Glu Val Glu Tyr Leu Leu Trp His Leu Ile 
                565                 570                 575     


Tyr Ser Val Lys Asp Lys Val Ala Tyr Glu Lys Gly Leu Lys Lys Phe 
            580                 585                 590         


Ala Gln Lys His His Leu Asp Lys Asp Ser Phe Val Glu Ser Phe Lys 
        595                 600                 605             


Lys Phe Asn Pro Tyr Pro Ser Glu Tyr Gly Ser Phe Ser Glu Lys Ala 
    610                 615                 620                 


Ile Arg Lys Leu Leu Pro Leu Met Arg Phe Gly Ala His Trp Asp Phe 
625                 630                 635                 640 


Asn His Ile Asp Lys Asn Thr Gln Lys Arg Ile Glu Asp Leu Ile Thr 
                645                 650                 655     


Gly Val Glu Asn Glu Glu Ile Arg Thr Ile Leu Arg Glu Lys Ala Glu 
            660                 665                 670         


Lys Tyr Gln Leu Glu Lys Glu Thr Asp Phe Gln Asp Leu Pro Leu Trp 
        675                 680                 685             


Leu Ala Gln Tyr Ile Val Tyr Asn Arg His Ala Glu Ala Ser Ser Leu 
    690                 695                 700                 


Glu Lys Trp Thr Ser Val Asn Asp Leu Glu Thr Tyr Leu Asn Glu Phe 
705                 710                 715                 720 


Lys Gln His Ser Leu Arg Asn Pro Ile Val Glu Gln Val Val Met Glu 
                725                 730                 735     


Thr Leu Arg Val Val Arg Asp Ile Trp Gln Gln Tyr Gly Gln Gly Gln 
            740                 745                 750         


Ala Ser Phe Phe Asn Glu Ile His Ile Glu Leu Gly Arg Glu Leu Lys 
        755                 760                 765             


Lys Thr Ala Lys Glu Arg Glu Lys Leu Ser Lys Gln Asn Gln Lys Asn 
    770                 775                 780                 


Glu Asp Ile Asn Leu Ser Ile Lys Glu Lys Leu Lys Glu Leu Glu Lys 
785                 790                 795                 800 


Tyr Asn Thr Arg Ala Tyr Ser Ile Thr His Gln Glu Lys Tyr Lys Leu 
                805                 810                 815     


Trp Leu Glu Gln Lys His Ile Ser Pro Tyr Thr Gly Gln Ile Ile Ser 
            820                 825                 830         


Pro Glu Asn Leu Phe Thr Asp Asn Tyr Glu Ile Glu His Ile Ile Pro 
        835                 840                 845             


Gln Ser Arg Phe Phe Asp Asp Ser Leu Ser Asn Lys Val Val Cys Glu 
    850                 855                 860                 


Ser Ile Val Asn Lys Ala Pro Tyr Lys Asp Arg Gln Leu Gly Leu Glu 
865                 870                 875                 880 


Phe Ile Lys Asn Gln Gly Gly Arg Ile Val Lys Glu Leu Ser Lys Glu 
                885                 890                 895     


Asn Lys Thr Ile Lys Ile Phe Thr Glu Glu Gln Tyr Arg Thr Phe Ile 
            900                 905                 910         


Lys Glu His Tyr Ser Asn Asn Pro Glu Lys Thr Lys Lys Leu Leu Leu 
        915                 920                 925             


Glu Glu Ile Pro Glu Lys Met Val Ala Arg Gln Met Asn Asp Thr Cys 
    930                 935                 940                 


Tyr Ile Ser Lys Phe Ile Ser Glu Ile Leu Ser Lys Ile Val Arg Ser 
945                 950                 955                 960 


Asp Glu Gln Asp Glu Gly Val His Ser Lys Asn Val Ile Leu Cys Thr 
                965                 970                 975     


Gly Lys Ile Thr Ser Ile Leu Arg Gln Asp Trp Gly Leu Asn Asp Ile 
            980                 985                 990         


Trp Asp Asn Leu Ile Leu Pro Arg  Phe Glu Arg Met Asn  Asn Leu Leu 
        995                 1000                 1005             


Gln Lys  Glu Lys Phe Thr Ile  Tyr Ser Ile Glu Lys  Gln Lys Lys 
    1010                 1015                 1020             


Ile Pro  Val Val Pro Ile Asn  Asp Gln Phe Lys Ser  Phe Gln Lys 
    1025                 1030                 1035             


Lys Arg  Ile Asp His Arg His  His Ala Met Asp Ala  Ile Ile Ile 
    1040                 1045                 1050             


Ala Cys  Thr Thr Arg Glu His  Ile Asn Tyr Ile Asn  Asn Gln His 
    1055                 1060                 1065             


Ala Leu  Glu Lys Glu Lys Asp  Lys Lys Glu Lys Gln  Glu Glu Arg 
    1070                 1075                 1080             


Asp Lys  Leu Arg Glu Lys Leu  Cys Ile Lys Lys Tyr  Asn Asn Arg 
    1085                 1090                 1095             


Ser Glu  Gly Asn Tyr Ser Trp  Ile Phe Lys Lys Pro  Trp Asp Thr 
    1100                 1105                 1110             


Phe Thr  Gln Glu Val Arg Val  Ala Leu Glu Asp Ile  Val Val Ser 
    1115                 1120                 1125             


Phe Lys  Gln Asn Leu Arg Val  Ile Asn Lys Ala Thr  Asn Tyr Tyr 
    1130                 1135                 1140             


Glu Arg  Trp Val Glu Glu Asn  Gly Lys Tyr Ile Lys  Lys Met Val 
    1145                 1150                 1155             


Lys Gln  Glu Gly Thr Asn Trp  Ala Ile Arg Lys Pro  Leu His Glu 
    1160                 1165                 1170             


Glu Thr  Ile Ser Gly Lys Ile  Tyr Leu Asp Arg Glu  Lys Ile Thr 
    1175                 1180                 1185             


Lys Asn  Asp Ile Leu Thr Ala  Thr Arg Lys Thr Val  Asp Ser Ser 
    1190                 1195                 1200             


Phe Asp  Asp Lys Arg Ile Lys  Lys Ile Thr Asp Thr  Gly Ile Gln 
    1205                 1210                 1215             


Lys Ile  Leu Leu Asn Tyr Leu  Lys Tyr Lys Gly Ser  Pro Glu Ile 
    1220                 1225                 1230             


Ala Phe  Ser Pro Glu Gly Leu  Glu Glu Leu Asn Lys  Asn Leu Ser 
    1235                 1240                 1245             


Ile Tyr  Asn Asp Gly Lys Pro  His Lys Pro Ile Tyr  Lys Val Arg 
    1250                 1255                 1260             


Ile Tyr  Glu Lys Gly Ser Gly  Arg Phe Ala Leu Gly  Glu Lys Gly 
    1265                 1270                 1275             


Arg Lys  Tyr Lys Lys Tyr Val  Gln Gly Ala Ser Asn  Leu Tyr Phe 
    1280                 1285                 1290             


Gly Ile  Tyr Gln Gly Ala Lys  Arg Ser Phe Ala Thr  Ile Pro Leu 
    1295                 1300                 1305             


Asn Glu  Val Ile Glu Arg Gln  Lys Gln Gly Leu Pro  Ser Val Pro 
    1310                 1315                 1320             


Glu Tyr  Asn Glu Lys Gly Asp  Leu Leu Leu Phe Ser  Leu Ser Pro 
    1325                 1330                 1335             


Asn Asp  Leu Val Tyr Val Pro  Ile Glu Gly Glu Ile  Ile Glu Asn 
    1340                 1345                 1350             


Ile Asp  Phe Arg Asn Leu Ser  Lys Glu Gln Lys Glu  Arg Ile Tyr 
    1355                 1360                 1365             


Asn Val  Asn Asp Phe Ser Ser  Thr Cys Tyr Phe Thr  Pro Asn Arg 
    1370                 1375                 1380             


Ile Ala  Lys Ala Ile Phe Pro  Lys Glu Val Asp Leu  Gln Arg Lys 
    1385                 1390                 1395             


Gly Asp  Lys Leu Ser Gly Ser  Tyr Asp Thr Lys Thr  Ala Ser Leu 
    1400                 1405                 1410             


Glu Gly  Ile Gln Ile Lys Glu  Val Cys Ile Lys Leu  Lys Val Asp 
    1415                 1420                 1425             


Arg Leu  Gly Asn Ile Ser Lys  Ala 
    1430                 1435     


<210> 152
<211> 1426
<212> PRT
<213> Capnocytophaga ochracea

<400> 152
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Phe 
1               5                   10                  15      


Ala His Ile Val Glu Asp Glu Asn Lys Glu Lys Ser Glu Ile Lys Glu 
            20                  25                  30          


Leu Gly Val Arg Ile Val Ser Leu Thr Thr Asp Glu Gln Ser Asp Phe 
        35                  40                  45              


Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asn Arg Thr Leu Lys His 
    50                  55                  60                  


Gly Ala Arg Leu Asn Leu Asp Arg Tyr Gln Gln Arg Arg Lys Tyr Leu 
65                  70                  75                  80  


Ile Asp Leu Leu Gln Lys Ala Asn Leu Ile Thr Pro Ser Ser Ile Leu 
                85                  90                  95      


Ala Glu Asn Gly Lys Asn Thr Thr His Ser Thr Trp Gln Leu Arg Ala 
            100                 105                 110         


Lys Ala Val Thr Glu Arg Ile Glu Lys Glu Glu Phe Ala Arg Ile Leu 
        115                 120                 125             


Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala Lys 
    130                 135                 140                 


Thr Glu Asp Glu Gly Gln Ala Ile Asp Gly Met Ala Ile Ala Lys Arg 
145                 150                 155                 160 


Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gln Leu Ser Leu Gln Leu Leu 
                165                 170                 175     


Gln Gln Asn Lys Lys Leu Leu Pro Asp Phe Tyr Arg Ser Asp Leu Gln 
            180                 185                 190         


Lys Glu Phe Asp Leu Val Trp Asn Phe Gln Lys Gln Phe Tyr Pro Asp 
        195                 200                 205             


Ile Leu Thr Asp Ile Phe Tyr Lys Glu Leu Gln Gly Lys Gly Lys Asp 
    210                 215                 220                 


Ala Thr Ser Lys Ala Phe Ser Lys Arg Tyr His Phe Asp Thr Thr Glu 
225                 230                 235                 240 


Asn Lys Gly Ser Lys Glu Ser Val Arg Leu Gln Ala Tyr Gln Trp Arg 
                245                 250                 255     


Ala Glu Ala Ile Ser Lys Gln Leu Ser Lys Glu Glu Val Ala Tyr Val 
            260                 265                 270         


Leu Thr Glu Ile Asn Asn Asn Leu Asn Asn Ala Ser Gly Tyr Leu Gly 
        275                 280                 285             


Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Arg Gln Thr Val 
    290                 295                 300                 


Gly Gln Tyr Leu Tyr Ala Lys Leu Gln Glu Asn Arg His Asn Ser Leu 
305                 310                 315                 320 


Lys Asn Lys Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu Arg 
                325                 330                 335     


Ile Trp Glu Thr Gln Ala Ser Phe His Lys Glu Leu Thr Asp Glu Leu 
            340                 345                 350         


Lys Lys Gln Ile Arg Asp Val Val Ile Phe Tyr Gln Arg Lys Pro Lys 
        355                 360                 365             


Ser Gln Lys Gly Leu Ile Ser Phe Cys Glu Phe Glu Ser Lys Glu Ile 
    370                 375                 380                 


Glu Ile Glu Lys Asp Gly Lys Thr Ile Thr Lys Asn Ile Gly Ala Arg 
385                 390                 395                 400 


Val Val Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln 
                405                 410                 415     


Ile Leu Asn Asn Val Ile Cys Lys Arg Lys Gly Ile Arg Lys Lys Lys 
            420                 425                 430         


Ile Ser Ala Lys Thr Thr Gln Leu Asp Leu Leu Asn Glu Ser Ser Gln 
        435                 440                 445             


Thr Ile Phe Ser Leu Asp Met Glu Cys Lys Gln Leu Leu Phe Asp Glu 
    450                 455                 460                 


Leu Asn Leu Lys Gly Asp Leu Lys Ser Asp Lys Val Leu Lys Leu Leu 
465                 470                 475                 480 


Gly Tyr Ser Pro Gln Glu Trp Glu Ile Asn Tyr Asn Gln Leu Glu Gly 
                485                 490                 495     


Asn Arg Thr Gln Lys Ala Leu Tyr Glu Ala Tyr Leu Lys Ile Val Glu 
            500                 505                 510         


Met Glu Ala His Asp Val Lys Asp Ile Leu Gln Ile Lys Ser Ala Lys 
        515                 520                 525             


Asp Asp Trp Ser Leu Asp Glu Ser Pro Leu Ser Ala Ser Glu Ile Arg 
    530                 535                 540                 


Glu Lys Val Lys Ala Ile Phe Gln Thr Leu Gly Ile Cys Thr Lys Ile 
545                 550                 555                 560 


Leu Tyr Phe Asp Pro Leu Leu Pro Val Lys Glu Phe Glu Glu Gln Asp 
                565                 570                 575     


Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asp Ser 
            580                 585                 590         


Thr Ser Gly Asn Glu Thr Leu Tyr Arg Ile Leu Glu Lys Lys Tyr Ala 
        595                 600                 605             


Phe Lys Arg Glu His Ala Arg Ile Leu Ala Asn Val Ala Leu Gln Asp 
    610                 615                 620                 


Asp Tyr Gly Ser Leu Ser Thr Lys Ala Ile Arg Lys Ile Tyr Pro Asn 
625                 630                 635                 640 


Ile Lys Glu Asn Gln Tyr Ser Thr Ala Cys Glu Lys Ala Gly Tyr Lys 
                645                 650                 655     


His Ser Lys Leu Ser Leu Thr Thr Glu Glu Leu Glu Ala Arg Glu Leu 
            660                 665                 670         


Lys Asn Ile Ile Pro Leu Leu Lys Lys Asn Ala Leu Arg Asn Pro Val 
        675                 680                 685             


Val Glu Lys Ile Leu Asn Gln Met Ile Asn Val Val Asn Ala Leu Ile 
    690                 695                 700                 


Glu Lys Asn Ser Glu Arg Asp Ala Glu Gly Lys Ile Thr Lys Tyr Phe 
705                 710                 715                 720 


His Phe Asp Glu Ile Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn 
                725                 730                 735     


Ala Gln Lys Arg Tyr Glu Met Thr Gln Asn Ile Asn Lys Ala Lys Leu 
            740                 745                 750         


Glu His Gln Lys Ile Ser Glu Ile Leu Gln Lys Glu Phe Gly Ile Lys 
        755                 760                 765             


Asn Pro Thr Lys Ser Asp Ile Ile Arg Tyr Arg Leu Tyr Gln Glu Leu 
    770                 775                 780                 


Glu His Asn Gly Tyr Lys Glu Leu Tyr Thr Asn Ala Pro Ile Ala Arg 
785                 790                 795                 800 


Asp Met Leu Phe Ser Lys Asn Ile Glu Ile Glu His Ile Val Pro Lys 
                805                 810                 815     


Ala Arg Val Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Thr Phe His 
            820                 825                 830         


Arg Ile Asn Ser Asp Lys Gly Glu Tyr Thr Ala Phe Asp Tyr Ile Thr 
        835                 840                 845             


Ser Leu Asn Ser Glu Glu Glu Leu Asn Gln Tyr Leu Thr Arg Val Glu 
    850                 855                 860                 


Asn Ala Tyr Lys Thr Lys Ser Ile Ser Pro Thr Lys Tyr Lys Asn Leu 
865                 870                 875                 880 


Leu Lys Lys Ala Ser Glu Ile Gly Asp Asp Phe Ile Asn Arg Asp Leu 
                885                 890                 895     


Arg Asp Thr Gln Tyr Ile Ala Lys Lys Ala Lys Glu Ile Leu Phe Gln 
            900                 905                 910         


Val Thr Lys Asn Val Leu Ser Thr Ser Gly Ser Ile Thr Asp Arg Leu 
        915                 920                 925             


Arg Glu Asp Trp Gly Leu Val Asp Val Met Lys Glu Leu Asn Met Pro 
    930                 935                 940                 


Lys Tyr Gln Ser Leu Gly Leu Thr Glu Val Glu Glu Arg Lys Asp Gly 
945                 950                 955                 960 


Asn Lys Val Thr Val Ile Lys Asn Trp Thr Lys Arg Asn Asp His Arg 
                965                 970                 975     


His His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Lys Pro Ser Tyr 
            980                 985                 990         


Ile Gln Tyr Leu Asn His Leu Asn  Ala Arg Lys Asp Glu  Asn Asn Lys 
        995                 1000                 1005             


Asn Tyr  Ser Val Ile Leu Ala  Ile Glu Glu Lys Glu  Thr Ile Lys 
    1010                 1015                 1020             


Val Pro  Thr Asn Asn Gly Lys  Asn Lys Arg Val Phe  Ile Glu Pro 
    1025                 1030                 1035             


Ile Pro  Asn Phe Arg Gln Val  Ala Lys Lys His Leu  Glu Glu Ile 
    1040                 1045                 1050             


Phe Ile  Ser His Lys Ala Lys  Asn Lys Val Val Thr  Lys Asn Thr 
    1055                 1060                 1065             


Asn Lys  Pro Ala Gly Thr Asp  Lys Gln Gln Ile Thr  Leu Thr Pro 
    1070                 1075                 1080             


Arg Gly  Gln Leu His Lys Glu  Thr Ile Tyr Gly Lys  Tyr Gln Tyr 
    1085                 1090                 1095             


Tyr Ile  Asn Lys Glu Glu Lys  Ile Gly Val Lys Phe  Asp Glu Arg 
    1100                 1105                 1110             


Thr Ile  Ala Lys Val Ser Asn  Pro Val Tyr Arg Glu  Ala Leu Leu 
    1115                 1120                 1125             


Lys Arg  Leu Gln Ala Asn Asp  Asn Asp Pro Lys Lys  Ala Phe Ala 
    1130                 1135                 1140             


Gly Lys  Asn Ala Leu Ser Lys  Asn Pro Ile Tyr Leu  Asp Glu Ser 
    1145                 1150                 1155             


Lys Thr  Lys Thr Leu Pro Glu  Lys Val Asn Leu Thr  Tyr Leu Glu 
    1160                 1165                 1170             


Glu Asp  Phe Ser Ile Arg Lys  Asp Ile Ser Pro Asp  Asn Phe Lys 
    1175                 1180                 1185             


Asp Leu  Lys Ser Ile Glu Lys  Val Ile Asp Gln Gly  Val Lys Arg 
    1190                 1195                 1200             


Ile Leu  Ile Lys Arg Leu Gln  Ala Tyr Asp Asn Asp  Pro Lys Lys 
    1205                 1210                 1215             


Ala Phe  Val Asp Leu Glu Lys  Asn Pro Ile Trp Leu  Asn Lys Glu 
    1220                 1225                 1230             


Lys Gly  Ile Ala Ile Lys Arg  Val Thr Ile Ser Gly  Val Asn Asn 
    1235                 1240                 1245             


Ala Gln  Pro Leu His Ile Gly  Lys Asp His Leu Gly  Lys Thr Thr 
    1250                 1255                 1260             


Leu Asn  Lys Glu Gly Lys Glu  Ile Pro Val Asp Tyr  Val Ser Thr 
    1265                 1270                 1275             


Gly Asn  Asn His His Val Ala  Ile Tyr Arg Asp Lys  Glu Gly Asn 
    1280                 1285                 1290             


Leu Gln  Glu Gln Ile Val Ser  Phe Phe Asp Ala Val  Val Arg Ala 
    1295                 1300                 1305             


Gln Gln  Gly Ile Pro Ile Ile  Asp Lys Thr Tyr Lys  Gln Ala Glu 
    1310                 1315                 1320             


Gly Trp  Gln Phe Leu Phe Thr  Met Lys Gln Asn Glu  Met Phe Val 
    1325                 1330                 1335             


Phe Pro  Asn Ala Thr Thr Gly  Phe Asn Pro Ala Glu  Ile Asp Leu 
    1340                 1345                 1350             


Leu Asp  Pro Lys Asn Lys Lys  Leu Ile Ser Pro Asn  Leu Phe Arg 
    1355                 1360                 1365             


Val Gln  Lys Ile Ala Thr Lys  Asp Tyr Phe Phe Arg  His His Leu 
    1370                 1375                 1380             


Glu Thr  Asn Val Glu Thr Asp  Asn Ile Leu Lys Asn  Val Thr Trp 
    1385                 1390                 1395             


Lys Arg  Glu Gly Leu Ser Gly  Leu Lys Asp Ile Val  Lys Val Arg 
    1400                 1405                 1410             


Ile Asn  His Leu Gly Asp Ile  Val Ser Ile Gly Glu  Tyr 
    1415                 1420                 1425     


<210> 153
<211> 1437
<212> PRT
<213> Capnocytophaga sp.


<220>
<223> Capnocytophaga sp. CM59

<400> 153
Met Lys Tyr Ile Lys Tyr Ile Leu Gly Leu Asp Ile Gly Ser Asn Ser 
1               5                   10                  15      


Ile Gly Trp Ala Leu Ile Gln Leu Asp Leu Leu Gln Lys Thr Lys Arg 
            20                  25                  30          


Ile Ile Ala Thr Gly Ser Arg Ile Ile Pro Met Asp Gln Lys Val Leu 
        35                  40                  45              


Ser Asp Phe Gly Lys Gly Ile Thr Ile Ser Pro Thr Ala Gln Arg Thr 
    50                  55                  60                  


Ser Tyr Arg Asn Ala Arg His Cys Arg Glu Arg His Leu Leu Arg Arg 
65                  70                  75                  80  


Glu Arg Leu His Arg Val Leu His Ile Leu Gly Phe Leu Pro Thr His 
                85                  90                  95      


Tyr Asp Lys Gln Ile Asp Phe Ser Lys Arg Tyr Gly Lys Phe Val Asp 
            100                 105                 110         


Asn Thr Glu Pro Lys Ile Ala Tyr Asn Glu Arg Lys Phe Leu Phe Met 
        115                 120                 125             


Asp Ser Phe Gln Glu Met Leu Ala Asp Phe Lys Ile His Gln Pro Asp 
    130                 135                 140                 


Leu Phe Tyr Thr Lys Lys Asn Gly Glu Glu Ser Lys Ile Pro Tyr Asp 
145                 150                 155                 160 


Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Arg Lys Ile Ser 
                165                 170                 175     


Lys Glu Glu Leu Ala Trp Ile Ile Leu Asn Phe Asn Gln Lys Arg Gly 
            180                 185                 190         


Tyr Tyr Gln Leu Arg Glu Glu Glu Glu Glu Asn Lys Glu Asn Asp Phe 
        195                 200                 205             


Glu Ile Ile Ser Ser Lys Ile Ile Ser Val Ile Lys Lys Asp Lys Asp 
    210                 215                 220                 


Lys Lys Tyr Asn Lys Tyr Trp Tyr Asp Ile Ile Leu Glu Asn Gly Leu 
225                 230                 235                 240 


Val Tyr Gln Ala Ala Phe Tyr Asn Asp Phe Val Tyr Asn Trp Ile Asn 
                245                 250                 255     


Gln Asp Arg Glu Phe Ile Ile Glu Arg Ile Ser Leu Lys Asn Gly Thr 
            260                 265                 270         


Glu Lys Val Lys Leu Ser Tyr Leu Pro Thr Phe Asp Glu Ile Asp Lys 
        275                 280                 285             


Met Asp Lys Lys Glu Gln Asp Lys Tyr Tyr Lys Lys Ile Lys Ile Lys 
    290                 295                 300                 


Thr Glu Asn Ser Ile Gly Asn Lys Thr Val Gly Cys Tyr Ile Tyr Asp 
305                 310                 315                 320 


His Ile Leu Gln Asn Pro Asn Glu Lys Ile Lys Gly Lys Leu Val Arg 
                325                 330                 335     


Thr Ile Glu Arg Lys Tyr Tyr Lys Glu Glu Leu Lys Ala Ile Leu Glu 
            340                 345                 350         


Lys Gln Val Ala Leu Gln Pro Glu Leu Phe Thr Asp Gln Leu Phe Ala 
        355                 360                 365             


Asp Cys Ile Arg Glu Leu Tyr Ser Lys Asn Glu Ala Gln Gln Arg Asn 
    370                 375                 380                 


Leu Ala Ala Arg Asp Phe Val His Leu Phe Val Glu Asp Ile Ile Phe 
385                 390                 395                 400 


Tyr Gln Arg Ser Leu Arg Arg Gln Lys Ser Thr Leu Ala Asn Cys Ser 
                405                 410                 415     


Leu Glu Ser Arg Ser Tyr Ile Asp Lys Asp Ser His Thr Arg Lys Glu 
            420                 425                 430         


Ala Pro Leu Lys Val Cys Pro Lys Ser Asn Pro Tyr Tyr Gln Glu Phe 
        435                 440                 445             


Arg Val Leu Gln Trp Leu Gln Asn Leu Lys Ile Tyr Glu Ile Asp Thr 
    450                 455                 460                 


Asp Gln Glu Val Thr His Glu Phe Ile Lys Thr Leu Glu Asp Lys Gln 
465                 470                 475                 480 


Gln Phe Phe Asp Phe Leu Met Asn Gln Lys Glu Ile Asp Cys Glu Glu 
                485                 490                 495     


Leu Leu Lys Tyr Phe Leu Asn Gln Thr Tyr Pro Asn Ala Arg Glu Lys 
            500                 505                 510         


Ala Leu Lys Ser Glu Leu Lys Lys Trp Lys Asp Thr Tyr Arg Trp Asn 
        515                 520                 525             


Tyr Val Tyr Asp Ile Gly Glu Lys Ser Ser Lys Lys Tyr Pro Met Asn 
    530                 535                 540                 


Glu Thr Arg Tyr Glu Leu Lys Arg His Leu Glu Lys Val Ala Asn Leu 
545                 550                 555                 560 


Pro Asp Asp Phe Leu Ser Ser Glu Val Glu Tyr Leu Leu Trp His Leu 
                565                 570                 575     


Ile Tyr Ser Val Lys Asp Lys Val Ala Tyr Glu Lys Gly Leu Lys Thr 
            580                 585                 590         


Phe Ala Gln Lys His His Leu Asp Lys Asp Ser Phe Val Glu Ser Phe 
        595                 600                 605             


Lys Lys Phe Lys Pro Tyr Pro Ser Glu Tyr Gly Ser Phe Ser Glu Lys 
    610                 615                 620                 


Ala Ile Arg Lys Leu Leu Pro Leu Met Arg Phe Gly Ser Tyr Trp Asp 
625                 630                 635                 640 


Phe Asn His Ile Asp Lys Asn Thr Gln Lys Arg Ile Glu Asp Leu Ile 
                645                 650                 655     


Thr Gly Val Glu Asn Glu Glu Ile Arg Thr Ile Leu Arg Glu Lys Ala 
            660                 665                 670         


Glu Lys Tyr Gln Leu Glu Lys Glu Thr Asp Phe Gln Asp Leu Pro Leu 
        675                 680                 685             


Trp Leu Ala Gln Tyr Ile Val Tyr Asn Arg His Ala Glu Ala Ser Ser 
    690                 695                 700                 


Leu Glu Lys Trp Thr Ser Val Asn Asp Leu Glu Thr Tyr Leu Asn Glu 
705                 710                 715                 720 


Phe Lys Gln Tyr Ser Leu Arg Asn Pro Ile Val Glu Gln Val Val Met 
                725                 730                 735     


Glu Thr Leu Arg Val Val Arg Asp Ile Trp Gln Gln Tyr Gly Gln Gly 
            740                 745                 750         


Gln Ala Ser Phe Phe Asp Glu Ile His Ile Glu Leu Gly Arg Glu Leu 
        755                 760                 765             


Lys Lys Thr Ala Lys Glu Arg Glu Lys Leu Ser Lys Gln Asn Gln Lys 
    770                 775                 780                 


Asn Glu Asp Ile Asn Leu Ser Ile Lys Glu Lys Leu Lys Glu Leu Glu 
785                 790                 795                 800 


Lys Tyr Asn Thr Arg Ala Tyr Ser Ile Thr His Gln Glu Lys Tyr Lys 
                805                 810                 815     


Leu Trp Leu Glu Gln Lys His Ile Ser Pro Tyr Thr Gly Gln Ile Ile 
            820                 825                 830         


Ser Pro Glu Asn Leu Phe Thr Asp Asn Tyr Glu Ile Glu His Ile Ile 
        835                 840                 845             


Pro Gln Ser Arg Phe Phe Asp Asp Ser Leu Ser Asn Lys Val Val Cys 
    850                 855                 860                 


Glu Ser Ile Val Asn Lys Ala Pro Tyr Lys Asp Arg Gln Leu Gly Leu 
865                 870                 875                 880 


Glu Phe Ile Lys Asn Gln Gly Gly Arg Ile Val Lys Glu Leu Ser Thr 
                885                 890                 895     


Glu Asn Lys Thr Ile Lys Ile Phe Thr Glu Glu Gln Tyr Arg Thr Phe 
            900                 905                 910         


Ile Lys Glu His Tyr Ser Asn Asn Pro Glu Lys Thr Lys Lys Leu Leu 
        915                 920                 925             


Leu Glu Glu Ile Pro Glu Lys Met Val Ala Arg Gln Met Asn Asp Thr 
    930                 935                 940                 


Cys Tyr Ile Ser Lys Phe Ile Ser Glu Ile Leu Ser Lys Ile Val Arg 
945                 950                 955                 960 


Ser Asp Glu Gln Asp Glu Gly Val His Ser Lys Asn Val Ile Leu Cys 
                965                 970                 975     


Thr Gly Lys Ile Thr Ser Ala Leu Lys Gln Asp Trp Gly Val Asn Asp 
            980                 985                 990         


Val Trp Asn Asp Leu Ile Leu Pro  Arg Phe Glu Arg Met  Asn Asp Leu 
        995                 1000                 1005             


Thr Gln  Ser Thr Leu Phe Thr  Thr Tyr Asn Glu Lys  Tyr Gln Lys 
    1010                 1015                 1020             


Tyr Leu  Pro Thr Val Pro Met  Glu Tyr Ser Asn Gly  Phe Gln Lys 
    1025                 1030                 1035             


Lys Arg  Ile Asp His Arg His  His Ala Met Asp Ala  Ile Ile Ile 
    1040                 1045                 1050             


Ala Cys  Ala Thr Arg Glu His  Ile Asn Tyr Ile Asn  Asn Gln His 
    1055                 1060                 1065             


Ala Leu  Glu Lys Gly Lys Asp  Lys Lys Glu Lys Gln  Lys Glu His 
    1070                 1075                 1080             


Asp Lys  Leu Arg Glu Lys Leu  Cys Ile Lys Lys Asp  Asn Lys Gly 
    1085                 1090                 1095             


Ser Glu  Glu Asn Tyr Ser Trp  Ile Phe Lys Lys Pro  Trp Asp Thr 
    1100                 1105                 1110             


Phe Thr  Gln Glu Val Gln Ala  Ala Leu Glu Gly Ile  Val Val Ser 
    1115                 1120                 1125             


Phe Lys  Gln Asn Leu Arg Val  Ile Asn Lys Ala Thr  Asn Tyr Tyr 
    1130                 1135                 1140             


Glu Arg  Trp Val Glu Glu Asn  Gly Lys Tyr Ile Lys  Lys Met Val 
    1145                 1150                 1155             


Lys Gln  Glu Gly Thr Asn Trp  Ala Ile Arg Lys Pro  Leu His Glu 
    1160                 1165                 1170             


Glu Thr  Ile Ser Gly Lys Ile  Tyr Leu Asp Arg Glu  Glu Ile Thr 
    1175                 1180                 1185             


Lys Asn  Asp Ile Leu Thr Ala  Thr Arg Lys Thr Val  Asp Ser Ser 
    1190                 1195                 1200             


Phe Asp  Glu Lys Arg Ile Lys  Lys Ile Thr Asp Thr  Gly Ile Gln 
    1205                 1210                 1215             


Lys Ile  Leu Leu Asn Tyr Leu  Lys Tyr Lys Gly Ser  Pro Glu Ile 
    1220                 1225                 1230             


Ala Phe  Ser Pro Glu Gly Leu  Glu Glu Leu Asn Lys  Asn Leu Ser 
    1235                 1240                 1245             


Ile Tyr  Asn Asp Gly Lys Pro  His Lys Pro Ile Tyr  Lys Val Arg 
    1250                 1255                 1260             


Ile Tyr  Glu Lys Gly Ser Gly  Arg Phe Ala Leu Gly  Glu Lys Gly 
    1265                 1270                 1275             


Arg Lys  Tyr Lys Lys Tyr Val  Gln Gly Ala Pro Asn  Leu Tyr Phe 
    1280                 1285                 1290             


Gly Ile  Tyr Gln Gly Ala Asn  Lys Arg Ser Phe Ala  Thr Ile Pro 
    1295                 1300                 1305             


Leu Asn  Glu Val Ile Glu Arg  Gln Lys Gln Gly Arg  Pro Ser Ile 
    1310                 1315                 1320             


Pro Glu  Tyr Asn Glu Lys Gly  Asp Pro Leu Leu Phe  Ser Leu Ser 
    1325                 1330                 1335             


Pro Asn  Asp Leu Val Tyr Val  Pro Val Glu Gly Glu  Ile Ile Glu 
    1340                 1345                 1350             


Asp Ile  Asp Phe Gln Asn Leu  Ser Lys Glu Gln Lys  Glu Arg Ile 
    1355                 1360                 1365             


Tyr Asn  Val Asn Asp Phe Ser  Ser Thr Cys Tyr Phe  Thr Pro Asn 
    1370                 1375                 1380             


Arg Ile  Ala Lys Ala Ile Phe  Pro Lys Glu Val Asp  Leu Gln Arg 
    1385                 1390                 1395             


Lys Gly  Asp Lys Leu Pro Gly  Ser Tyr Asp Thr Lys  Thr Ala Ser 
    1400                 1405                 1410             


Leu Glu  Gly Ile Gln Ile Lys  Glu Val Cys Ile Lys  Leu Lys Ile 
    1415                 1420                 1425             


Asp Arg  Leu Gly Asn Ile Ser  Lys Ala 
    1430                 1435         


<210> 154
<211> 1471
<212> PRT
<213> Capnocytophaga sp.


<220>
<223> Capnocytophaga sp. oral taxon 324 str. F0483

<400> 154
Met Cys Lys Tyr Phe Tyr Ile Lys Asn Phe Ile Thr Phe Val Leu Ser 
1               5                   10                  15      


Lys Ser Ile Ile Pro Met Lys His Ile Leu Gly Leu Asp Leu Gly Ser 
            20                  25                  30          


Asn Ser Ile Gly Trp Ala Phe Val Gln Gln Asp Phe Glu Asn Lys Gln 
        35                  40                  45              


Gly Lys Ile Ile Ala Thr Gly Ser Arg Ile Ile Pro Met Asp Gln Gly 
    50                  55                  60                  


Ile Leu Gly Asp Phe Glu Arg Gly Asn Thr Val Ser Gln Thr Ala Glu 
65                  70                  75                  80  


Arg Thr Thr Tyr Arg Ser Thr Arg Arg Leu Arg Glu Arg His Leu Leu 
                85                  90                  95      


Arg Arg Glu Arg Leu His Arg Val Leu His Ile Leu Gly Phe Leu Pro 
            100                 105                 110         


Pro His Tyr Asp Ala Gln Ile Asp Phe Thr Lys Arg Tyr Gly Lys Phe 
        115                 120                 125             


Ile Asp Asn Ala Glu Pro Lys Ile Ala Tyr Asn Asn Gly Asn Phe Ile 
    130                 135                 140                 


Phe Met Asn Ser Phe Asn Glu Met Ile Glu Asp Phe Lys Lys His Gln 
145                 150                 155                 160 


Pro Gln Leu Phe Tyr Lys Lys Ser Asn Gly Glu Glu Ser Lys Ile Pro 
                165                 170                 175     


Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Gln Lys 
            180                 185                 190         


Ile Thr Gln Gln Glu Leu Ala Trp Leu Ile Leu His Phe Asn Gln Lys 
        195                 200                 205             


Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Glu Thr Glu Asn Pro Asn 
    210                 215                 220                 


Lys Glu Val Ala Phe His Ser Leu Lys Val Val Asp Val Glu Ala Glu 
225                 230                 235                 240 


Ala Pro Asn Lys Lys Gly Glu Ile Trp Tyr Thr Ile Arg Leu Glu Asn 
                245                 250                 255     


Gly Trp Ile Tyr Arg Arg Thr Ser Lys Ile Pro Leu Asp Asp Trp Lys 
            260                 265                 270         


Gly Lys Thr Arg Asp Phe Ile Val Thr Thr Asp Leu Asn Asp Asp Gly 
        275                 280                 285             


Thr Ile Lys Val Asp Lys Glu Gly Lys Glu Lys Arg Ser Phe Arg Ala 
    290                 295                 300                 


Pro Asp Glu Asn Asp Trp Asn Leu Leu Lys Lys Lys Thr Glu His Asp 
305                 310                 315                 320 


Ile Asp Phe Ser Gly Lys Thr Val Gly Ala Tyr Ile Tyr Asp His Leu 
                325                 330                 335     


Leu Gln Asn Pro Asn Gln Lys Ile Lys Gly Lys Leu Val Arg Thr Ile 
            340                 345                 350         


Glu Arg Lys Tyr Tyr Lys Asp Glu Leu Lys Ala Ile Leu Ala Lys Gln 
        355                 360                 365             


Ile Ala Leu Gln Pro Glu Leu Phe Thr Glu Thr Leu Leu Ala Asp Cys 
    370                 375                 380                 


Ile Arg Glu Leu Tyr Arg Lys Asn Glu Thr Gln Gln Gln Asn Leu Leu 
385                 390                 395                 400 


Ser Lys Asp Phe Leu His Leu Phe Val Glu Asp Ile Ile Phe Tyr Gln 
                405                 410                 415     


Arg Pro Leu Arg Ser Lys Lys Ser Thr Ile Ala Asn Cys Thr Leu Glu 
            420                 425                 430         


Lys Arg Ser Tyr Ile Asp Lys Glu Thr Asn Glu Arg Lys Asp Ala Pro 
        435                 440                 445             


Ile Lys Val Cys Ala Lys Ser Asn Pro Tyr Tyr Gln Glu Phe Arg Val 
    450                 455                 460                 


Leu Gln Trp Leu Gln Asn Leu Arg Ile Tyr Glu Ile Glu Thr Asp Arg 
465                 470                 475                 480 


Glu Val Thr Ala Glu Phe Ile Glu Thr Pro Gln Asp Cys Glu Ala Leu 
                485                 490                 495     


Phe Asn Phe Leu Met Ser Gln Lys Glu Ile Asp Asn Lys Gly Leu Leu 
            500                 505                 510         


Lys Tyr Phe Leu Phe Ala Lys Asn Pro Gln Ile Lys Asp Lys Ala Ala 
        515                 520                 525             


Lys Ser Glu Leu Lys Lys Trp Leu Thr Thr Tyr Arg Trp Asn Tyr Val 
    530                 535                 540                 


Tyr Asp Ala Ala Asp Asn Ser Ser Lys Lys Tyr Pro Met Asn Glu Thr 
545                 550                 555                 560 


Gly Tyr Glu Leu Gln Arg Tyr Leu Gln Lys Val Glu Gly Leu Pro Ala 
                565                 570                 575     


Asn Phe Leu Thr Phe Asp Ile Thr Tyr Gln Leu Trp His Leu Leu Tyr 
            580                 585                 590         


Ser Val Lys Asp Lys Val Glu Phe Glu Lys Ala Leu Lys Lys Phe Ala 
        595                 600                 605             


Lys Lys Lys Gln Leu Asp Lys Thr Ser Phe Val Asp Ser Phe Lys Asn 
    610                 615                 620                 


Phe Lys Pro Tyr Pro Asn Glu Tyr Gly Ser Phe Ser Glu Lys Ala Ile 
625                 630                 635                 640 


Lys Lys Leu Leu Pro Leu Met Arg Phe Gly Asn His Trp Asp Phe Asn 
                645                 650                 655     


Arg Ile Asp Val Ser Thr Gln Lys Arg Ile Asp Asp Leu Ile Asn Gly 
            660                 665                 670         


Val Ala Asn Glu Asp Ile Arg Thr Ile Ile Arg Glu Lys Ala Glu Lys 
        675                 680                 685             


Tyr Gln Leu Asn Ser Glu Thr Cys Phe Gln Asp Leu Pro Leu Trp Leu 
    690                 695                 700                 


Ala Gln Tyr Val Val Tyr Asn Arg His Ala Glu Ala Thr Asp Ile Glu 
705                 710                 715                 720 


Lys Trp Thr Ser Val Ser Asp Leu Glu Ala Tyr Leu Glu Asp Phe Lys 
                725                 730                 735     


Gln His Ser Leu Arg Asn Pro Ile Val Glu Gln Val Val Thr Glu Thr 
            740                 745                 750         


Leu Arg Val Val Arg Asp Ile Trp Gln Gln Tyr Gly Gly Gly Gln Ala 
        755                 760                 765             


Asn Phe Phe Asp Glu Ile His Ile Glu Leu Gly Arg Glu Leu Lys Lys 
    770                 775                 780                 


Thr Ala Glu Glu Arg Lys Gln Leu Ser Asp Lys Asn Gln Glu Asn Glu 
785                 790                 795                 800 


Ser Thr Asn Leu Arg Ile Lys Lys Leu Leu Ala Glu Leu Lys Glu Asp 
                805                 810                 815     


Ala Ser Ile Gln Asn Val Arg Pro Tyr Ser Leu Val Gln Gln Glu Leu 
            820                 825                 830         


Leu Lys Ile Tyr Glu Glu Gly Val Phe Ser Ala Thr Asp Glu Val Glu 
        835                 840                 845             


Glu Asp Ile Gln Lys Ile Arg Lys Lys Ala Glu Pro Ser Lys Ala Asp 
    850                 855                 860                 


Leu Gln Arg Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Lys Ser Pro Tyr 
865                 870                 875                 880 


Thr Gly Glu Val Ile Ser Leu Thr Lys Leu Phe Thr Glu Glu Tyr Glu 
                885                 890                 895     


Ile Glu His Ile Ile Pro Gln Ser Arg Tyr Tyr Asp Asp Ser Leu Ser 
            900                 905                 910         


Asn Lys Val Ile Cys Glu Ser Ala Val Asn Lys Leu Lys Thr Asn Gln 
        915                 920                 925             


Leu Gly Leu Glu Phe Ile Gln Asn His His Gly Glu Lys Val Arg Ile 
    930                 935                 940                 


Thr Ala Asn Lys Glu Val Thr Ile Phe Thr Glu Glu Gln Tyr Lys Glu 
945                 950                 955                 960 


Phe Val Lys Lys His Tyr Ala Asn Asn Ser Ala Lys Gln Gln Lys Leu 
                965                 970                 975     


Leu Leu Asn Glu Ile Pro Glu Lys Met Val Ala Arg Gln Leu Asn Asp 
            980                 985                 990         


Thr Arg Tyr Ile Ser Lys Tyr Ile  Ser Glu Ile Leu Ser  Lys Ile Val 
        995                 1000                 1005             


Arg Ser  Asp Glu Lys Asp Glu  Gly Val Asn Ser Lys  Asn Ile Ile 
    1010                 1015                 1020             


Pro Cys  Thr Gly Lys Ile Thr  Thr Ala Leu Lys Gln  Asp Trp Gly 
    1025                 1030                 1035             


Leu Asn  Asp Val Trp Asn Lys  Leu Ile Leu Pro Arg  Phe Glu Arg 
    1040                 1045                 1050             


Met Asn  Gln Leu Thr Gln Thr  Gln Leu Phe Thr Ser  Tyr Asn Asp 
    1055                 1060                 1065             


Arg Leu  Gln Lys Asn Leu Pro  Thr Val Pro Ile Glu  Tyr Ser Gln 
    1070                 1075                 1080             


Gly Phe  Gln Lys Lys Arg Ile  Asp His Arg His His  Ala Met Asp 
    1085                 1090                 1095             


Ala Leu  Val Ile Ala Cys Ala  Thr Arg Glu His Ile  Asn Tyr Met 
    1100                 1105                 1110             


Asn Asn  Gln His Ala Leu Asp  Lys Ser Lys Asp Lys  Lys Glu Lys 
    1115                 1120                 1125             


Gln Gln  Ser Arg Ile Asp Leu  Arg Thr Ile Leu Cys  Glu Lys Lys 
    1130                 1135                 1140             


Asn Asn  Asn Trp Gln Phe Lys  Lys Pro Trp Ser Thr  Phe Thr Gln 
    1145                 1150                 1155             


Glu Ala  Lys Glu Ala Leu Glu  His Ile Val Val Ser  Phe Lys Gln 
    1160                 1165                 1170             


Asn Leu  Arg Val Ile Asn Lys  Ala Thr Asn Tyr Tyr  Glu Lys Trp 
    1175                 1180                 1185             


Glu Glu  Lys Asn Gly Val Leu  Val Lys Lys Lys Val  Lys Gln Glu 
    1190                 1195                 1200             


Gly Thr  Asn Trp Ala Ile Arg  Lys Pro Leu His Lys  Glu Thr Val 
    1205                 1210                 1215             


Ser Gly  Lys Ile Val Leu Asp  Arg Lys Ile Gly Lys  Asp Lys Ile 
    1220                 1225                 1230             


Leu Thr  Ala Thr Arg Lys Ala  Val Asp Ile Thr Phe  Thr Glu Lys 
    1235                 1240                 1245             


Ile Ile  Ser Ser Ile Thr Asp  Thr Gly Ile Gln Lys  Ile Leu Leu 
    1250                 1255                 1260             


Asn Tyr  Leu Lys Tyr Lys Gly  Ser Pro Glu Val Ala  Phe Ser Thr 
    1265                 1270                 1275             


Glu Gly  Leu Glu Glu Leu Asn  Lys Asn Ile Ala Gln  Tyr Asn Asn 
    1280                 1285                 1290             


Gly Lys  Lys His Gln Pro Ile  Tyr Lys Val Arg Ile  Phe Glu Glu 
    1295                 1300                 1305             


Gly Ser  Lys Phe Pro Leu Gly  Glu Thr Gly Ala Lys  Ala Thr Lys 
    1310                 1315                 1320             


Tyr Val  Glu Ala Ala Lys Gly  Thr Asn Leu Phe Phe  Gly Val Tyr 
    1325                 1330                 1335             


Gln Gly  Lys Gly Lys Arg Thr  Tyr Ala Thr Ile Pro  Leu Asn Glu 
    1340                 1345                 1350             


Val Ile  Glu Arg Gln Lys Gln  Gly Leu Pro Ser Val  Pro Glu Arg 
    1355                 1360                 1365             


Asn Glu  Lys Gly Glu Pro Leu  Leu Phe Ser Leu Ser  Pro Asn Asp 
    1370                 1375                 1380             


Leu Val  Tyr Val Pro Met Glu  Gly Glu Ile Ala Glu  Thr Ile Asp 
    1385                 1390                 1395             


Phe Asn  Asn Leu Ser Lys Glu  Gln Lys Glu Arg Ile  Tyr Lys Thr 
    1400                 1405                 1410             


Val Ser  Phe Thr Gly Asn Gln  Cys Phe Phe Val Gln  Glu Ala Val 
    1415                 1420                 1425             


Ala Thr  Pro Ile Val Asn Lys  Met Glu Tyr Ser Pro  Leu Asn Lys 
    1430                 1435                 1440             


Met Glu  Arg Asp Ile Leu Gly  Thr Met Ile Lys Glu  Val Cys Ile 
    1445                 1450                 1455             


Lys Leu  Lys Val Asp Arg Leu  Gly Asn Ile Thr Lys  Ala 
    1460                 1465                 1470     


<210> 155
<211> 1450
<212> PRT
<213> Capnocytophaga sp.


<220>
<223> Capnocytophaga sp. oral taxon 326 str. F0382

<400> 155
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Ser Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Val Glu Gln Asp Phe Glu Asn Lys Gln Gly Lys Ile Ile Ala 
            20                  25                  30          


Thr Gly Ser Arg Ile Ile Pro Met Asp Gln Gly Ile Leu Gly Asp Phe 
        35                  40                  45              


Glu Lys Gly Asn Thr Val Ser Gln Thr Ala Glu Arg Thr Thr Tyr Arg 
    50                  55                  60                  


Ser Met Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu His Ile Leu Gly Phe Leu Pro Pro His Tyr Asp Ala 
                85                  90                  95      


Gln Ile Asp Phe Thr Lys Arg Tyr Gly Lys Phe Ile Asp Asn Ala Glu 
            100                 105                 110         


Pro Lys Ile Ala Tyr Asn Asn Gly Asn Phe Ile Phe Met Asn Ser Phe 
        115                 120                 125             


Asn Glu Met Ile Glu Asp Phe Lys Lys Tyr Gln Pro Gln Leu Phe Tyr 
    130                 135                 140                 


Lys Lys Ser Asn Gly Glu Glu Ser Lys Ile Pro Tyr Asp Trp Thr Ile 
145                 150                 155                 160 


Tyr Tyr Leu Arg Lys Lys Val Leu Ser Gln Lys Ile Thr Gln Gln Glu 
                165                 170                 175     


Leu Ala Trp Leu Ile Leu His Phe Asn Gln Lys Arg Gly Tyr Tyr Gln 
            180                 185                 190         


Leu Arg Gly Glu Glu Glu Thr Glu Asn Pro Asn Lys Glu Val Ala Phe 
        195                 200                 205             


His Ser Leu Lys Val Val Asp Val Glu Ala Glu Ala Pro Asn Lys Lys 
    210                 215                 220                 


Gly Glu Ile Trp Tyr Thr Ile Arg Leu Glu Asn Gly Trp Ile Tyr Arg 
225                 230                 235                 240 


Arg Thr Ser Lys Ile Pro Leu Asp Asp Trp Lys Gly Lys Thr Arg Asp 
                245                 250                 255     


Phe Ile Val Thr Thr Asp Leu Asn Asp Asp Gly Thr Ile Lys Val Asp 
            260                 265                 270         


Lys Glu Gly Lys Glu Lys Arg Ser Phe Arg Ala Pro Asp Glu Asn Asp 
        275                 280                 285             


Trp Asn Leu Leu Lys Lys Lys Thr Glu His Asp Ile Asp Phe Ser Gly 
    290                 295                 300                 


Lys Thr Val Gly Ala Tyr Ile Tyr Asp His Leu Leu Gln Asn Pro Asn 
305                 310                 315                 320 


Gln Lys Ile Lys Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Tyr Tyr 
                325                 330                 335     


Lys Asp Glu Leu Lys Ala Ile Leu Ala Lys Gln Ile Ala Leu Gln Pro 
            340                 345                 350         


Glu Leu Phe Thr Glu Thr Leu Leu Ala Asp Cys Ile Arg Glu Leu Tyr 
        355                 360                 365             


Arg Lys Asn Glu Thr Gln Gln Gln Asn Leu Leu Ser Lys Asp Phe Leu 
    370                 375                 380                 


His Leu Phe Val Glu Asp Ile Ile Phe Tyr Gln Arg Pro Leu Arg Ser 
385                 390                 395                 400 


Lys Lys Ser Thr Ile Ala Asn Cys Thr Leu Glu Lys Arg Ser Tyr Ile 
                405                 410                 415     


Asp Lys Glu Thr Asn Glu Arg Lys Asp Thr Phe Ile Lys Val Cys Ala 
            420                 425                 430         


Lys Ser Asn Pro Tyr Tyr Gln Glu Phe Arg Val Leu Gln Trp Leu Gln 
        435                 440                 445             


Asn Leu Arg Ile Tyr Glu Ile Glu Thr Asp Arg Glu Val Thr Ala Glu 
    450                 455                 460                 


Phe Ile Glu Thr Ala Glu Asp Tyr Glu Ala Leu Phe Asn Phe Leu Met 
465                 470                 475                 480 


Ser Gln Lys Glu Ile Asp Asn Glu Gly Leu Leu Lys Tyr Phe Leu Phe 
                485                 490                 495     


Ala Lys Asn Pro Gln Ile Lys Asp Lys Val Ala Lys Ser Glu Leu Lys 
            500                 505                 510         


Lys Trp Leu Thr Thr Tyr Arg Trp Asn Tyr Val Tyr Asp Ala Ala Asp 
        515                 520                 525             


Asn Ser Ser Lys Lys Tyr Pro Met Asn Glu Thr Gly Tyr Asp Leu Gln 
    530                 535                 540                 


Arg Tyr Leu Gln Lys Val Glu Gly Leu Pro Ala Asn Phe Leu Thr Phe 
545                 550                 555                 560 


Asp Ile Thr Tyr Arg Leu Trp His Leu Leu Tyr Ser Val Lys Asp Lys 
                565                 570                 575     


Val Glu Phe Glu Lys Ala Leu Lys Lys Phe Ala Gln Glu Tyr Gln Leu 
            580                 585                 590         


Asp Glu Ala Ser Phe Val Asp Ser Phe Lys Asn Phe Lys Pro Tyr Pro 
        595                 600                 605             


Asn Glu Tyr Gly Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro 
    610                 615                 620                 


Leu Met Arg Phe Gly Asn His Trp Asp Phe Asn Arg Ile Asp Val Ser 
625                 630                 635                 640 


Thr Gln Lys Arg Ile Asp Asp Leu Ile Asn Gly Val Ala Asn Asp Glu 
                645                 650                 655     


Ile Arg Thr Ile Ile Arg Glu Lys Ala Glu Lys Tyr Gln Leu Asn Ser 
            660                 665                 670         


Glu Ser Cys Phe Gln Gly Leu Pro Leu Trp Leu Ala Gln Tyr Val Val 
        675                 680                 685             


Tyr Asn Arg His Ala Glu Ala Thr Asp Ile Glu Lys Trp Thr Ser Val 
    690                 695                 700                 


Ser Asp Leu Glu Thr Tyr Leu Glu Asp Phe Lys Gln His Ser Leu Arg 
705                 710                 715                 720 


Asn Pro Ile Val Glu Gln Val Val Thr Glu Thr Leu Arg Val Val Arg 
                725                 730                 735     


Asp Ile Trp Gln Gln Tyr Gly Gly Gly Gln Ala Asn Phe Phe Asp Glu 
            740                 745                 750         


Ile His Ile Glu Leu Gly Arg Glu Leu Lys Lys Thr Ala Glu Glu Arg 
        755                 760                 765             


Lys Gln Leu Ser Asn Arg Asn Gln Glu Asn Glu Asn Thr Asn Leu Arg 
    770                 775                 780                 


Ile Lys Lys Leu Leu Ala Glu Leu Lys Glu Asp Ala Ser Ile Gln Asn 
785                 790                 795                 800 


Val Arg Pro Tyr Ser Pro Val Gln Gln Glu Leu Leu Lys Ile Tyr Glu 
                805                 810                 815     


Glu Gly Val Phe Ser Ser Thr Asp Gln Val Glu Glu Asp Ile Gln Lys 
            820                 825                 830         


Ile Arg Lys Lys Ala Glu Pro Thr Thr Pro Glu Ile Gln Arg Tyr Lys 
        835                 840                 845             


Leu Trp Leu Glu Gln Lys Tyr Lys Ser Pro Tyr Thr Gly Glu Val Ile 
    850                 855                 860                 


Ser Leu Thr Lys Leu Phe Thr Glu Glu Tyr Glu Ile Glu His Ile Ile 
865                 870                 875                 880 


Pro Gln Ser Arg Tyr Tyr Asp Asp Ser Leu Ser Asn Lys Val Ile Cys 
                885                 890                 895     


Glu Ser Ala Val Asn Lys Leu Lys Thr Asn Gln Leu Gly Leu Glu Phe 
            900                 905                 910         


Ile Gln Asn His His Gly Glu Lys Val Arg Ile Thr Gly Asn Lys Glu 
        915                 920                 925             


Val Thr Ile Phe Thr Glu Glu Gln Tyr Lys Glu Phe Val Lys Lys His 
    930                 935                 940                 


Tyr Ala Asn Asn Ser Ala Lys Gln Gln Lys Leu Leu Leu Asn Glu Ile 
945                 950                 955                 960 


Pro Glu Lys Met Val Ala Arg Gln Leu Asn Asp Thr Arg Tyr Ile Ser 
                965                 970                 975     


Lys Tyr Ile Ser Glu Ile Leu Ser Lys Ile Val Arg Ser Asp Glu Lys 
            980                 985                 990         


Asp Glu Gly Val Asn Ser Lys Asn  Val Ile Pro Cys Thr  Gly Lys Ile 
        995                 1000                 1005             


Thr Thr  Ala Leu Lys Gln Asp  Trp Gly Leu Asn Asp  Val Trp Asn 
    1010                 1015                 1020             


Glu Leu  Ile Leu Pro Arg Phe  Glu Arg Met Asn Gln  Leu Thr Gln 
    1025                 1030                 1035             


Thr Gln  Leu Phe Thr Ser Tyr  Asn Asp Arg Phe Gln  Lys Asn Leu 
    1040                 1045                 1050             


Pro Thr  Val Pro Ile Glu Tyr  Ser Gln Gly Phe Gln  Lys Lys Arg 
    1055                 1060                 1065             


Ile Asp  His Arg His His Ala  Met Asp Ala Leu Val  Ile Ala Cys 
    1070                 1075                 1080             


Ala Thr  Arg Glu His Ile Asn  Tyr Met Asn Asn Gln  His Ala Leu 
    1085                 1090                 1095             


Asp Lys  Asn Lys Asp Lys Lys  Glu Lys Gln Gln Ser  Arg Ile Asp 
    1100                 1105                 1110             


Leu Arg  Thr Ile Leu Cys Glu  Lys Lys Asn Asn Asn  Trp Gln Phe 
    1115                 1120                 1125             


Lys Lys  Pro Trp Ser Thr Phe  Thr Gln Glu Thr Lys  Glu Ala Leu 
    1130                 1135                 1140             


Glu His  Ile Val Val Ser Phe  Lys Gln Asn Leu Arg  Val Ile Asn 
    1145                 1150                 1155             


Lys Ala  Thr Asn Tyr Tyr Glu  Lys Trp Glu Glu Lys  Asn Gly Val 
    1160                 1165                 1170             


Leu Val  Lys Lys Lys Val Lys  Gln Glu Gly Thr Asn  Trp Ala Ile 
    1175                 1180                 1185             


Arg Lys  Pro Leu His Lys Glu  Thr Val Ser Gly Lys  Ile Val Leu 
    1190                 1195                 1200             


Asp Arg  Lys Ile Gly Lys Asp  Lys Ile Leu Thr Ala  Thr Arg Lys 
    1205                 1210                 1215             


Glu Val  Asp Ile Thr Phe Thr  Glu Lys Ile Ile Ser  Ser Ile Thr 
    1220                 1225                 1230             


Asp Thr  Gly Ile Gln Lys Ile  Leu Leu Asn Tyr Leu  Asn Tyr Lys 
    1235                 1240                 1245             


Gly Ser  Pro Glu Val Ala Phe  Ser Ala Glu Gly Leu  Glu Glu Leu 
    1250                 1255                 1260             


Asn Lys  Asn Ile Ala Gln Tyr  Asn Asp Gly Lys Lys  His Gln Pro 
    1265                 1270                 1275             


Ile Tyr  Lys Val Arg Ile Phe  Glu Glu Gly Ser Lys  Phe Pro Leu 
    1280                 1285                 1290             


Gly Glu  Thr Gly Ala Lys Ala  Thr Lys Phe Val Glu  Ala Ala Lys 
    1295                 1300                 1305             


Gly Thr  Asn Leu Phe Phe Gly  Val Tyr Gln Gly Lys  Glu Lys Arg 
    1310                 1315                 1320             


Ser Tyr  Ala Thr Ile Pro Leu  Asn Glu Val Ile Glu  Arg Gln Lys 
    1325                 1330                 1335             


Gln Gly  Leu Pro Ser Val Pro  Glu Arg Asn Glu Lys  Gly Glu Pro 
    1340                 1345                 1350             


Leu Leu  Phe Ser Leu Ser Pro  Asn Asp Leu Val Tyr  Val Pro Met 
    1355                 1360                 1365             


Glu Gly  Glu Ile Ala Glu Thr  Ile Asp Phe Asn Asn  Leu Ser Lys 
    1370                 1375                 1380             


Glu Gln  Lys Glu Arg Ile Tyr  Lys Thr Val Ser Phe  Thr Gly Asn 
    1385                 1390                 1395             


Gln Cys  Phe Phe Val Gln Glu  Ala Val Ala Thr Pro  Ile Val Asn 
    1400                 1405                 1410             


Lys Met  Glu Tyr Ser Pro Leu  Asn Lys Met Glu Arg  Asp Ile Leu 
    1415                 1420                 1425             


Gly Thr  Met Ile Lys Glu Val  Cys Ile Lys Leu Lys  Val Asp Arg 
    1430                 1435                 1440             


Leu Gly  Asn Ile Thr Lys Ala  
    1445                 1450 


<210> 156
<211> 1435
<212> PRT
<213> Capnocytophaga sp.


<220>
<223> Capnocytophaga sp. oral taxon 329 str. F0087

<400> 156
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Phe 
1               5                   10                  15      


Ala His Ile Val Glu Asp Glu Asn Lys Glu Lys Ser Glu Ile Lys Glu 
            20                  25                  30          


Leu Gly Val Arg Ile Val Ser Leu Ala Thr Asp Glu Gln Ser Asp Phe 
        35                  40                  45              


Glu Lys Gly Lys Ser Ile Ser Thr Asn Ala Asn Arg Thr Leu Lys His 
    50                  55                  60                  


Gly Ala Arg Leu Asn Leu Asp Arg Tyr Gln Gln Arg Arg Lys Phe Leu 
65                  70                  75                  80  


Ile Asp Leu Leu Gln Lys Ala Asn Leu Ile Thr Ser Ala Ser Ile Leu 
                85                  90                  95      


Ala Glu Asn Gly Lys Asn Thr Thr His Ser Thr Trp Gln Leu Arg Ala 
            100                 105                 110         


Lys Ala Val Thr Glu Arg Ile Glu Lys Glu Glu Phe Ala Arg Val Leu 
        115                 120                 125             


Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Asn Ser Arg Lys Thr Lys 
    130                 135                 140                 


Thr Glu Asp Glu Gly Gln Ala Ile Asp Gly Met Ala Ile Ala Lys Cys 
145                 150                 155                 160 


Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gln Leu Ser Leu Gln Leu Leu 
                165                 170                 175     


Gln Gln Asn Lys Lys Leu Leu Pro Asp Phe Tyr Arg Ser Asp Leu Gln 
            180                 185                 190         


Lys Glu Phe Asp Leu Val Trp Asn Leu Gln Lys Gln Phe Tyr Pro Asp 
        195                 200                 205             


Ile Leu Thr Asp Ser Phe Tyr Lys Glu Leu Gln Gly Lys Gly Lys Asp 
    210                 215                 220                 


Ala Thr Ser Lys Ala Phe Ser Lys Arg Tyr His Phe Asp Thr Ala Glu 
225                 230                 235                 240 


Asn Lys Gly Ser Lys Glu Ser Val Arg Leu Gln Ala Tyr Gln Trp Arg 
                245                 250                 255     


Ala Glu Ala Ile Ser Lys Gln Leu Ser Lys Glu Glu Val Ala Tyr Val 
            260                 265                 270         


Leu Thr Glu Ile Asn Asn Asn Leu Asn Asn Ser Ser Gly Tyr Leu Gly 
        275                 280                 285             


Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Arg Gln Thr Val 
    290                 295                 300                 


Gly Gln Tyr Leu Tyr Ala Gln Leu Gln Glu Asn Arg His Asn Ser Leu 
305                 310                 315                 320 


Lys Asn Lys Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu Arg 
                325                 330                 335     


Ile Trp Glu Thr Gln Ala Ser Phe His Lys Glu Leu Thr Asp Glu Leu 
            340                 345                 350         


Lys Lys Gln Ile Arg Asp Val Val Ile Phe Tyr Gln Arg Lys Leu Lys 
        355                 360                 365             


Ser Gln Lys Gly Leu Val Ser Phe Cys Glu Phe Glu Ser Lys Glu Ile 
    370                 375                 380                 


Glu Ile Glu Lys Asp Gly Lys Ala Ile Thr Lys Ser Ile Gly Ala Arg 
385                 390                 395                 400 


Val Val Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln 
                405                 410                 415     


Ile Leu Asn Asn Val Thr Cys Lys Arg Lys Gly Ile Arg Lys Lys Lys 
            420                 425                 430         


Ser Ser Ala Lys Ser Thr Glu Leu Asp Leu Phe Asn Glu Pro Ser Gln 
        435                 440                 445             


Ser Ile Phe Ser Leu Asp Met Glu Cys Lys Gln Leu Leu Phe Asp Glu 
    450                 455                 460                 


Leu Asn Leu Lys Gly Asp Leu Lys Ser Asp Lys Val Leu Lys Leu Leu 
465                 470                 475                 480 


Gly Tyr Ser Pro Gln Glu Trp Glu Ile Asn Tyr Asn Gln Leu Glu Gly 
                485                 490                 495     


Asn Arg Thr Gln Lys Ser Leu Tyr Glu Ala Tyr Leu Lys Ile Ile Glu 
            500                 505                 510         


Ile Glu Gly Tyr Glu Val Lys Asp Ile Leu Gln Ile Lys Ser Thr Lys 
        515                 520                 525             


Asp Asp Trp Ser Leu Asp Glu Ser Pro Leu Ser Ala Ser Glu Ile Arg 
    530                 535                 540                 


Glu Arg Val Lys Val Ile Phe Gln Thr Leu Gly Ile Cys Thr Lys Ile 
545                 550                 555                 560 


Leu Tyr Phe Asp Pro Leu Leu Pro Val Lys Glu Phe Glu Gln Gln Tyr 
                565                 570                 575     


Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asp Ser 
            580                 585                 590         


Thr Ser Gly Asn Glu Thr Leu Tyr Arg Ile Leu Glu Lys Lys Tyr Ala 
        595                 600                 605             


Phe Lys Arg Glu His Ala Thr Ile Leu Ala Asn Val Ala Leu Gln Asp 
    610                 615                 620                 


Asp Tyr Gly Ser Leu Ser Thr Lys Ala Ile Arg Lys Ile Tyr Pro Tyr 
625                 630                 635                 640 


Ile Lys Glu Asn Gln Tyr Ser Thr Ala Cys Glu Leu Ala Gly Tyr Lys 
                645                 650                 655     


His Ser Lys Leu Ser Leu Thr Thr Glu Glu Leu Glu Ala Arg Glu Leu 
            660                 665                 670         


Lys Asn Ile Ile Pro Leu Leu Lys Lys Asn Ala Leu Arg Asn Pro Val 
        675                 680                 685             


Val Glu Lys Ile Leu Asn Gln Met Ile Asn Val Val Asn Ala Leu Ile 
    690                 695                 700                 


Glu Lys Asn Ser Glu Arg Asp Ala Glu Gly Lys Ile Thr Lys Tyr Phe 
705                 710                 715                 720 


His Phe Asp Glu Ile Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn 
                725                 730                 735     


Ala Gln Glu Arg Tyr Glu Met Thr Gln Asn Ile Asn Lys Ala Lys Leu 
            740                 745                 750         


Glu His Gln Lys Ile Ser Glu Lys Leu Gln Lys Gln Phe Gly Ile Lys 
        755                 760                 765             


Asn Pro Thr Lys Ser Asp Ile Ile Arg Tyr Arg Leu Tyr Gln Glu Leu 
    770                 775                 780                 


Glu His Asn Gly Tyr Lys Glu Leu Tyr Thr Asn Thr Tyr Ile Ala Pro 
785                 790                 795                 800 


Asp Val Leu Phe Ser Lys Asn Ile Asp Ile Glu His Ile Val Pro Lys 
                805                 810                 815     


Ala Arg Val Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Ala Phe Lys 
            820                 825                 830         


Glu Phe Asn Ile Lys Lys Gly Glu Ser Thr Ala Phe Asp Tyr Ile Thr 
        835                 840                 845             


Ser Leu Asn Cys Glu Gly Glu Leu Asn Gln Tyr Leu Thr Arg Val Glu 
    850                 855                 860                 


Asn Ala Tyr Lys Thr Lys Ser Ile Ser Leu Thr Lys Tyr Lys Asn Leu 
865                 870                 875                 880 


Leu Lys Lys Ala Ser Glu Ile Gly Asp Gly Phe Ile Asn Arg Asp Leu 
                885                 890                 895     


Arg Asp Thr Gln Tyr Ile Ala Lys Lys Ala Lys Glu Ile Leu Phe Gln 
            900                 905                 910         


Val Thr Lys Asn Val Leu Ser Thr Ser Gly Ser Ile Thr Asp Arg Leu 
        915                 920                 925             


Arg Glu Asp Trp Gly Leu Val Asp Val Met Lys Glu Leu Asn Met Pro 
    930                 935                 940                 


Lys Tyr Gln Ser Leu Gly Leu Thr Glu Val Glu Glu Arg Lys Asp Gly 
945                 950                 955                 960 


Asn Lys Val Thr Val Ile Lys Asp Trp Thr Lys Arg Asn Asp His Arg 
                965                 970                 975     


His His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Lys Pro Ser Tyr 
            980                 985                 990         


Ile Gln Tyr Leu Asn His Leu Asn  Ala Arg Lys Asp Glu  Asn Asn Lys 
        995                 1000                 1005             


Asn Tyr  Ser Val Ile Leu Ala  Ile Glu Lys Lys Glu  Thr Ile Lys 
    1010                 1015                 1020             


Val Pro  Ile Asn Asn Gly Lys  Asn Lys Arg Val Phe  Ile Glu Pro 
    1025                 1030                 1035             


Ile Leu  Asn Phe Arg Gln Val  Ala Lys Lys His Leu  Glu Glu Ile 
    1040                 1045                 1050             


Phe Ile  Ser His Lys Ala Lys  Asn Lys Val Val Thr  Lys Asn Ile 
    1055                 1060                 1065             


Asn Lys  Pro Ala Gly Thr Asp  Lys Gln Gln Ile Thr  Leu Thr Pro 
    1070                 1075                 1080             


Arg Gly  Gln Leu His Lys Glu  Thr Ile Tyr Gly Lys  Tyr Gln Tyr 
    1085                 1090                 1095             


Tyr Val  Asn Lys Glu Glu Lys  Val Gly Val Lys Phe  Asp Glu Arg 
    1100                 1105                 1110             


Thr Ile  Thr Lys Val Ser Asn  Pro Leu Tyr Arg Glu  Ala Leu Leu 
    1115                 1120                 1125             


Lys Arg  Leu Gln Ala Asn Asp  Asn Asp Pro Lys Lys  Ala Phe Ala 
    1130                 1135                 1140             


Gly Lys  Asn Ala Leu Ser Lys  Asn Pro Ile Tyr Leu  Asp Glu Ala 
    1145                 1150                 1155             


Lys Thr  Lys Thr Leu Pro Glu  Lys Val Asn Leu Thr  Tyr Leu Glu 
    1160                 1165                 1170             


Glu Asp  Phe Ser Ile Arg Lys  Asp Ile Ser Pro Asp  Asn Phe Lys 
    1175                 1180                 1185             


Asp Leu  Lys Ser Ile Glu Lys  Val Ile Asp Gln Gly  Val Lys Arg 
    1190                 1195                 1200             


Ile Leu  Ile Lys Arg Leu Gln  Ala Tyr Asp Asn Asp  Pro Lys Lys 
    1205                 1210                 1215             


Ala Phe  Val Asp Leu Glu Lys  Asn Pro Ile Trp Leu  Asn Lys Glu 
    1220                 1225                 1230             


Lys Gly  Ile Ala Ile Lys Arg  Val Thr Ile Ser Gly  Val Ser Asn 
    1235                 1240                 1245             


Ala Gln  Pro Leu His Ile Gly  Lys Asp His Leu Gly  Lys Thr Thr 
    1250                 1255                 1260             


Leu Asn  Lys Glu Gly Lys Glu  Val Pro Val Asp Tyr  Val Ser Thr 
    1265                 1270                 1275             


Gly Asn  Asn His His Val Ala  Ile Tyr Arg Asp Lys  Glu Gly Asn 
    1280                 1285                 1290             


Leu Gln  Glu Gln Ile Val Ser  Phe Phe Glu Ala Val  Val Arg Ala 
    1295                 1300                 1305             


Gln Gln  Gly Leu Pro Ile Ile  Asp Lys Asn Tyr Lys  Gln Ala Glu 
    1310                 1315                 1320             


Gly Trp  Gln Phe Met Phe Thr  Met Lys Gln Asn Glu  Met Phe Val 
    1325                 1330                 1335             


Phe Pro  Asn Glu Ala Thr Gly  Phe Asn Pro Ala Glu  Ile Asp Leu 
    1340                 1345                 1350             


Leu Asp  Pro Lys Asn Lys Lys  Leu Ile Ser Pro Asn  Leu Phe Arg 
    1355                 1360                 1365             


Val Gln  Thr Ile Ser Ile Val  Lys Tyr Gly Asn Ser  Val Val Arg 
    1370                 1375                 1380             


Asp Phe  Lys Phe Arg His His  Leu Glu Thr Thr Leu  Gln Asp Asp 
    1385                 1390                 1395             


Lys Ile  Leu Gln Gly Ile Thr  Phe Gln Gln Ile Lys  Ser Leu Glu 
    1400                 1405                 1410             


Pro Leu  Arg Asn Ile Val Lys  Val Arg Ile Asn His  Leu Gly Asp 
    1415                 1420                 1425             


Ile Val  Asn Ile Gly Glu Tyr  
    1430                 1435 


<210> 157
<211> 1426
<212> PRT
<213> Capnocytophaga sp.


<220>
<223> Capnocytophaga sp. oral taxon 335 str. F0486

<400> 157
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Phe 
1               5                   10                  15      


Thr His Ile Val Glu Asp Glu Asn Lys Glu Lys Ser Glu Ile Lys Glu 
            20                  25                  30          


Leu Gly Val Arg Ile Val Ser Leu Thr Thr Asp Glu Gln Ser Asp Phe 
        35                  40                  45              


Glu Lys Gly Lys Ser Ile Ser Thr Asn Ala Asn Arg Thr Leu Lys His 
    50                  55                  60                  


Gly Ala Arg Leu Asn Leu Asp Arg Tyr Gln Gln Arg Arg Lys Phe Leu 
65                  70                  75                  80  


Ile Asp Leu Leu Gln Lys Ala Asn Leu Ile Thr Ser Ser Ser Ile Leu 
                85                  90                  95      


Ala Glu Asn Gly Lys Asn Thr Thr His Ser Thr Trp Gln Leu Arg Ala 
            100                 105                 110         


Lys Ala Val Thr Glu Arg Ile Glu Lys Glu Glu Phe Ala Arg Val Leu 
        115                 120                 125             


Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala Lys 
    130                 135                 140                 


Thr Glu Asp Glu Gly Gln Ala Ile Asp Gly Met Ala Ile Ala Lys Arg 
145                 150                 155                 160 


Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gln Leu Ser Leu Gln Leu Leu 
                165                 170                 175     


Gln Gln Asn Lys Lys Leu Leu Pro Asp Phe Tyr Arg Ser Asp Leu Gln 
            180                 185                 190         


Lys Glu Phe Asp Leu Val Trp Asn Phe Gln Lys Gln Phe Tyr Pro Asp 
        195                 200                 205             


Ile Leu Thr Asp Ser Phe Tyr Lys Glu Leu Gln Gly Lys Gly Lys Asp 
    210                 215                 220                 


Ala Thr Ser Lys Ala Phe Ser Lys Arg Tyr His Phe Asp Thr Ala Glu 
225                 230                 235                 240 


Asn Lys Gly Ser Arg Glu Ser Val Arg Leu Gln Ala Tyr Gln Trp Arg 
                245                 250                 255     


Ala Glu Ala Ile Ser Lys Gln Leu Ser Lys Glu Glu Val Ala Tyr Val 
            260                 265                 270         


Leu Thr Glu Ile Asn Asn Asn Leu Asn Asn Ala Ser Gly Tyr Leu Gly 
        275                 280                 285             


Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Arg Gln Thr Val 
    290                 295                 300                 


Gly Gln Tyr Leu Tyr Ala Gln Leu Gln Glu Asn Lys His Asn Ser Leu 
305                 310                 315                 320 


Lys Asn Lys Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu Arg 
                325                 330                 335     


Ile Trp Glu Thr Gln Ala Ser Phe His Lys Glu Leu Thr Glu Glu Leu 
            340                 345                 350         


Lys Lys Gln Ile Arg Asp Val Val Ile Phe Tyr Gln Arg Lys Leu Lys 
        355                 360                 365             


Ser Gln Lys Gly Leu Ile Ser Phe Cys Glu Phe Glu Ser Lys Glu Ile 
    370                 375                 380                 


Glu Ile Glu Lys Asp Gly Lys Thr Ile Thr Lys Ser Ile Gly Ala Arg 
385                 390                 395                 400 


Val Val Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln 
                405                 410                 415     


Ile Leu Asn Asn Val Thr Cys Lys Arg Lys Gly Ile Arg Lys Lys Lys 
            420                 425                 430         


Ser Ser Ala Lys Ser Thr Glu Leu Asp Leu Phe Asn Glu Pro Ser Gln 
        435                 440                 445             


Thr Ile Phe Ser Leu Asp Met Glu Cys Lys Gln Leu Leu Phe Glu Glu 
    450                 455                 460                 


Leu Asn Leu Lys Gly Asp Leu Lys Ser Asp Lys Val Leu Lys Leu Leu 
465                 470                 475                 480 


Gly Tyr Ser Pro Gln Glu Trp Glu Ile Asn Tyr Asn Gln Leu Glu Gly 
                485                 490                 495     


Asn Arg Thr Gln Lys Ala Leu Tyr Glu Ala Tyr Leu Lys Ile Val Glu 
            500                 505                 510         


Met Glu Ala His Asp Val Lys Asp Ile Leu Gln Ile Lys Ser Thr Lys 
        515                 520                 525             


Asp Asp Trp Ala Leu Glu Glu Ser Pro Leu Ser Ala Ser Glu Ile Arg 
    530                 535                 540                 


Glu Arg Val Lys Ala Ile Phe Gln Thr Leu Gly Ile Cys Thr Lys Ile 
545                 550                 555                 560 


Leu Tyr Phe Asp Pro Leu Leu Pro Val Lys Glu Phe Glu Glu Gln Asp 
                565                 570                 575     


Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asp Ser 
            580                 585                 590         


Thr Ser Gly Asn Glu Thr Leu Tyr Arg Ile Leu Glu Lys Lys Tyr Ala 
        595                 600                 605             


Phe Lys Arg Glu His Ala Thr Ile Leu Ala Asn Val Thr Leu Gln Asp 
    610                 615                 620                 


Asp Tyr Gly Ser Leu Ser Thr Lys Ala Ile Arg Lys Ile Tyr Pro Tyr 
625                 630                 635                 640 


Ile Lys Glu Asn Gln Tyr Ser Thr Ala Cys Glu Lys Ala Gly Tyr Lys 
                645                 650                 655     


His Ser Lys Leu Ser Leu Thr Thr Glu Glu Leu Glu Ala Arg Glu Leu 
            660                 665                 670         


Lys Asn Ile Ile Pro Leu Leu Lys Lys Asn Ala Leu Arg Asn Pro Val 
        675                 680                 685             


Val Glu Lys Ile Leu Asn Gln Met Ile Asn Val Val Asn Ala Leu Ile 
    690                 695                 700                 


Glu Lys Asn Ser Glu Arg Asp Ala Glu Gly Lys Ile Thr Lys Tyr Phe 
705                 710                 715                 720 


His Phe Asp Glu Ile Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn 
                725                 730                 735     


Ala Gln Glu Arg Tyr Glu Met Thr Gln Asn Ile Asn Lys Ala Lys Leu 
            740                 745                 750         


Glu His Gln Lys Ile Ser Gly Ile Leu Gln Lys Glu Phe Gly Ile Lys 
        755                 760                 765             


Asn Pro Thr Lys Ser Asp Ile Thr Arg Tyr Arg Leu Tyr Gln Glu Leu 
    770                 775                 780                 


Ala His Asn Gly Tyr Asn Asp Leu Tyr Thr Asn Thr Tyr Ile Pro Lys 
785                 790                 795                 800 


Glu Leu Leu Phe Ser Lys Asn Ile Asp Ile Glu His Ile Val Ser Lys 
                805                 810                 815     


Ala Arg Val Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Ala Phe Arg 
            820                 825                 830         


Glu Phe Asn Ile Lys Lys Gly Glu Ser Thr Ala Phe Asp Tyr Ile Thr 
        835                 840                 845             


Ser Leu Asn Asn Glu Glu Glu Leu Asn Gln Tyr Leu Asn Arg Val Glu 
    850                 855                 860                 


Asn Ala Tyr Lys Thr Lys Asn Ile Ser Pro Ala Lys Tyr Lys Asn Leu 
865                 870                 875                 880 


Leu Lys Lys Ala Ser Glu Ile Gly Asp Gly Phe Ile Asn Arg Asp Leu 
                885                 890                 895     


Arg Asp Thr Gln Tyr Ile Ala Lys Lys Ala Lys Glu Ile Leu Phe Gln 
            900                 905                 910         


Val Thr Lys Asn Val Leu Ser Thr Ser Gly Ser Ile Thr Asp Arg Leu 
        915                 920                 925             


Arg Glu Asp Trp Gly Leu Val Asp Val Met Lys Glu Leu Asn Met Pro 
    930                 935                 940                 


Lys Tyr Gln Ser Leu Gly Leu Thr Glu Val Glu Glu Arg Lys Glu Gly 
945                 950                 955                 960 


Asn Lys Val Thr Val Ile Lys Asn Trp Thr Lys Arg Asn Asp His Arg 
                965                 970                 975     


His His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Lys Pro Ser Tyr 
            980                 985                 990         


Ile Gln Tyr Leu Asn His Leu Asn  Ala Arg Lys Asp Lys  Asn Asn Lys 
        995                 1000                 1005             


Asn Tyr  Ser Val Ile Leu Ala  Ile Glu Glu Lys Glu  Thr Ile Lys 
    1010                 1015                 1020             


Val Pro  Thr Asn Asn Gly Lys  Asn Lys Arg Val Phe  Ile Glu Pro 
    1025                 1030                 1035             


Ile Pro  Asn Phe Arg Gln Val  Ala Lys Lys His Leu  Glu Glu Ile 
    1040                 1045                 1050             


Phe Ile  Ser His Lys Ala Lys  Asn Lys Val Val Thr  Lys Asn Thr 
    1055                 1060                 1065             


Asn Lys  Pro Ala Gly Thr Asp  Lys Gln Gln Ile Thr  Leu Thr Pro 
    1070                 1075                 1080             


Arg Gly  Gln Leu His Lys Glu  Thr Val Tyr Gly Lys  Tyr Gln Tyr 
    1085                 1090                 1095             


Tyr Val  Asn Lys Glu Glu Lys  Ile Gly Val Lys Phe  Asp Lys Glu 
    1100                 1105                 1110             


Thr Ile  Ala Lys Val Ser Asn  Pro Val Tyr Arg Glu  Ala Leu Leu 
    1115                 1120                 1125             


Lys Arg  Leu Gln Ala Asn Asp  Asn Asp Pro Lys Lys  Ala Phe Ala 
    1130                 1135                 1140             


Gly Lys  Asn Ala Leu Ser Lys  Asn Pro Ile Tyr Leu  Asp Glu Ala 
    1145                 1150                 1155             


Lys Thr  Lys Thr Leu Thr Glu  Lys Val Asn Leu Thr  Tyr Leu Glu 
    1160                 1165                 1170             


Glu Asp  Phe Ser Ile Arg Lys  Asp Ile Ser Pro Asp  Asn Phe Lys 
    1175                 1180                 1185             


Asp Leu  Lys Ser Ile Glu Lys  Val Ile Asp Gln Gly  Val Lys Arg 
    1190                 1195                 1200             


Ile Leu  Ile Lys Arg Leu Gln  Asp Tyr Asp Asn Asp  Pro Lys Lys 
    1205                 1210                 1215             


Ala Phe  Val Asp Leu Glu Lys  Asn Pro Ile Trp Leu  Asn Lys Glu 
    1220                 1225                 1230             


Lys Gly  Ile Ala Ile Lys Arg  Val Thr Ile Ser Gly  Val Asn Asn 
    1235                 1240                 1245             


Ala Gln  Pro Leu His Ile Gly  Lys Asp His Leu Gly  Lys Thr Thr 
    1250                 1255                 1260             


Leu Asn  Lys Glu Gly Lys Glu  Ile Pro Val Asp Tyr  Val Ser Thr 
    1265                 1270                 1275             


Gly Asn  Asn His His Val Ala  Ile Tyr Arg Asp Lys  Glu Gly Asn 
    1280                 1285                 1290             


Leu Gln  Glu Gln Ile Val Ser  Phe Phe Glu Ala Val  Val Gly Ala 
    1295                 1300                 1305             


Gln Gln  Gly Leu Pro Ile Val  Asp Lys Thr Tyr Lys  Gln Ala Glu 
    1310                 1315                 1320             


Gly Trp  Gln Phe Leu Phe Thr  Met Lys Gln Asn Glu  Met Phe Val 
    1325                 1330                 1335             


Phe Pro  Asn Glu Ala Thr Gly  Phe Asn Pro Ala Glu  Ile Asp Leu 
    1340                 1345                 1350             


Leu Asp  Pro Lys Asn Lys Lys  Gln Ile Ser Pro Asn  Leu Phe Arg 
    1355                 1360                 1365             


Val Gln  Lys Ile Ala Thr Lys  Asp Tyr Phe Phe Arg  His His Leu 
    1370                 1375                 1380             


Glu Thr  Asn Val Asp Thr Asp  Asn Val Leu Lys Asn  Thr Thr Trp 
    1385                 1390                 1395             


Lys Arg  Glu Gly Leu Ser Gly  Leu Lys Asp Ile Val  Lys Val Arg 
    1400                 1405                 1410             


Ile Asn  His Leu Gly Asp Ile  Val Ser Ile Gly Glu  Tyr 
    1415                 1420                 1425     


<210> 158
<211> 1432
<212> PRT
<213> Capnocytophaga sp.


<220>
<223> Capnocytophaga sp. oral taxon 380 str. F0488

<400> 158
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Phe 
1               5                   10                  15      


Ala His Ile Val Glu Asp Glu Asn Lys Glu Lys Ser Glu Ile Lys Glu 
            20                  25                  30          


Leu Gly Val Arg Ile Val Ser Leu Thr Thr Asp Glu Gln Ser Asp Phe 
        35                  40                  45              


Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asn Arg Thr Leu Lys His 
    50                  55                  60                  


Gly Ala Arg Leu Asn Leu Asp Arg Tyr Gln Gln Arg Arg Lys Tyr Leu 
65                  70                  75                  80  


Ile Asp Leu Leu His Lys Ala Asn Leu Ile Thr Pro Ser Ser Ile Leu 
                85                  90                  95      


Ala Glu Asn Gly Lys Asn Thr Thr His Ser Thr Trp Gln Leu Arg Ala 
            100                 105                 110         


Lys Ala Val Thr Glu Arg Ile Glu Lys Glu Glu Phe Ala Arg Ile Leu 
        115                 120                 125             


Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala Lys 
    130                 135                 140                 


Thr Glu Asp Glu Gly Gln Ala Ile Asp Gly Met Ala Ile Ala Lys Arg 
145                 150                 155                 160 


Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gln Leu Ser Leu Gln Leu Leu 
                165                 170                 175     


Gln Gln Asn Lys Lys Leu Leu Pro Asp Phe Tyr Arg Ser Asp Leu Gln 
            180                 185                 190         


Lys Glu Phe Asp Leu Val Trp Asn Phe Gln Lys Gln Phe Tyr Pro Asp 
        195                 200                 205             


Ile Leu Thr Asp Ile Phe Tyr Lys Glu Leu Gln Gly Lys Gly Lys Asp 
    210                 215                 220                 


Ala Thr Ser Lys Ala Phe Ser Lys Arg Tyr His Phe Asp Thr Ala Glu 
225                 230                 235                 240 


Asn Lys Gly Ser Lys Glu Ser Val Arg Leu Gln Ala Tyr Gln Trp Arg 
                245                 250                 255     


Ala Glu Ala Val Ser Lys Gln Leu Ser Lys Glu Glu Val Ala Tyr Val 
            260                 265                 270         


Leu Thr Glu Ile Asn Asn Asn Leu Asn Asn Ala Ser Gly Tyr Leu Gly 
        275                 280                 285             


Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Arg Gln Thr Val 
    290                 295                 300                 


Gly Gln Tyr Leu Tyr Ala Gln Leu Gln Glu Asn Arg His Asn Ser Leu 
305                 310                 315                 320 


Lys Asn Lys Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu Arg 
                325                 330                 335     


Ile Trp Glu Thr Gln Ala Leu Phe His Lys Glu Leu Thr Asp Glu Leu 
            340                 345                 350         


Lys Lys Gln Ile Arg Asp Val Val Ile Phe Tyr Gln Arg Lys Pro Lys 
        355                 360                 365             


Ser Gln Lys Gly Leu Ile Ser Phe Cys Glu Phe Glu Ser Lys Glu Ile 
    370                 375                 380                 


Glu Ile Glu Lys Asp Gly Lys Thr Ile Thr Lys Asn Ile Gly Ala Arg 
385                 390                 395                 400 


Val Val Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln 
                405                 410                 415     


Ile Leu Asn Asn Val Ile Cys Lys Arg Lys Gly Ile Arg Lys Lys Lys 
            420                 425                 430         


Ile Ser Ala Lys Thr Thr Gln Leu Asp Leu Leu Asn Glu Ser Ser Gln 
        435                 440                 445             


Thr Ile Phe Ser Leu Asp Met Glu Cys Lys Gln Leu Leu Phe Asp Glu 
    450                 455                 460                 


Leu Asn Leu Lys Gly Asp Leu Lys Ser Asp Lys Val Leu Lys Leu Leu 
465                 470                 475                 480 


Gly Tyr Ser Pro Gln Glu Trp Glu Ile Asn Tyr Asn Gln Leu Glu Gly 
                485                 490                 495     


Asn Arg Thr Gln Lys Ala Leu Tyr Glu Ala Tyr Leu Lys Ile Val Glu 
            500                 505                 510         


Met Glu Ala His Asp Val Lys Asp Ile Leu Gln Ile Lys Ser Thr Lys 
        515                 520                 525             


Asp Asp Trp Ser Leu Asp Glu Ser Pro Leu Ser Ala Ser Glu Ile Arg 
    530                 535                 540                 


Glu Ser Val Lys Ala Ile Phe Gln Ala Leu Gly Ile Cys Thr Lys Ile 
545                 550                 555                 560 


Leu Tyr Phe Asp Pro Leu Leu Pro Val Lys Asp Phe Glu Glu Gln Asp 
                565                 570                 575     


Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asp Ser 
            580                 585                 590         


Thr Ser Gly Asn Glu Thr Leu Tyr Arg Ile Leu Glu Lys Lys Tyr Ala 
        595                 600                 605             


Phe Lys Arg Glu His Ala Arg Ile Leu Ala Asn Val Ala Leu Gln Asp 
    610                 615                 620                 


Asp Tyr Gly Ser Leu Ser Thr Lys Ala Ile Arg Lys Ile Tyr Pro Asn 
625                 630                 635                 640 


Ile Lys Glu Asn Gln Tyr Ser Thr Ala Cys Glu Met Ala Gly Tyr Lys 
                645                 650                 655     


His Ser Lys Leu Ser Leu Thr Thr Glu Glu Leu Glu Ala Arg Glu Leu 
            660                 665                 670         


Lys Asn Ile Ile Pro Leu Leu Lys Lys Asn Ala Leu Arg Asn Pro Val 
        675                 680                 685             


Val Glu Lys Ile Leu Asn Gln Met Ile Asn Val Val Asn Ala Leu Ile 
    690                 695                 700                 


Glu Lys Asn Ser Glu Arg Asp Ala Glu Gly Lys Ile Thr Lys Tyr Phe 
705                 710                 715                 720 


His Phe Asp Glu Ile Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn 
                725                 730                 735     


Ala Gln Lys Arg Tyr Glu Met Thr Gln Asn Ile Asn Lys Ala Lys Ser 
            740                 745                 750         


Glu His Gln Lys Ile Ser Glu Ile Leu Gln Lys Glu Phe Gly Ile Lys 
        755                 760                 765             


Asn Pro Thr Lys Ser Asp Ile Ile Arg Tyr Arg Leu Tyr Lys Glu Leu 
    770                 775                 780                 


Glu His Asn Gly Tyr Lys Glu Leu Tyr Thr Asn Thr Tyr Ile Ala Pro 
785                 790                 795                 800 


Asp Val Leu Phe Ser Lys Asn Ile Asp Ile Glu His Ile Val Pro Lys 
                805                 810                 815     


Ala Arg Val Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Ala Phe Lys 
            820                 825                 830         


Asp Phe Asn Ile Lys Lys Gly Glu Ser Thr Ala Phe Asp Tyr Ile Thr 
        835                 840                 845             


Ser Leu Lys Asn Glu Glu Lys Leu Asn Gln Tyr Leu Ala Arg Val Glu 
    850                 855                 860                 


Asn Ala Tyr Lys Thr Lys Asn Ile Ser Pro Ala Lys Tyr Lys Asn Leu 
865                 870                 875                 880 


Leu Lys Lys Ala Ser Glu Ile Gly Asp Gly Phe Ile Asn Arg Asp Leu 
                885                 890                 895     


Arg Asp Thr Gln Tyr Ile Ala Lys Lys Ala Lys Glu Ile Leu Phe Gln 
            900                 905                 910         


Val Thr Lys Asn Val Leu Ser Thr Ser Gly Ser Ile Thr Asp Arg Leu 
        915                 920                 925             


Arg Glu Asp Trp Ser Leu Val Asp Val Met Lys Glu Leu Asn Met Pro 
    930                 935                 940                 


Lys Tyr Gln Ser Leu Gly Leu Thr Glu Val Glu Glu Arg Lys Asp Gly 
945                 950                 955                 960 


Asn Lys Val Thr Val Ile Lys Asp Trp Thr Lys Arg Asn Asp His Arg 
                965                 970                 975     


His His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Lys Pro Ser Tyr 
            980                 985                 990         


Ile Gln Tyr Leu Asn His Leu Asn  Ala Arg Lys Asp Glu  Asn Asn Lys 
        995                 1000                 1005             


Asn Tyr  Ser Val Ile Leu Ala  Ile Glu Lys Lys Glu  Thr Ile Lys 
    1010                 1015                 1020             


Val Pro  Thr Asn Asn Gly Lys  Asn Lys Arg Val Phe  Ile Glu Pro 
    1025                 1030                 1035             


Ile Pro  Asn Phe Arg Gln Val  Ala Lys Lys His Leu  Glu Glu Ile 
    1040                 1045                 1050             


Phe Ile  Ser His Lys Ala Lys  Asn Lys Val Val Thr  Lys Asn Thr 
    1055                 1060                 1065             


Asn Lys  Pro Ala Gly Thr Asn  Lys Gln Gln Ile Thr  Leu Thr Pro 
    1070                 1075                 1080             


Arg Gly  Gln Leu His Lys Glu  Thr Ile Tyr Gly Lys  Tyr Gln Tyr 
    1085                 1090                 1095             


Tyr Val  Asn Lys Glu Glu Lys  Val Gly Val Lys Phe  Asp Lys Glu 
    1100                 1105                 1110             


Thr Ile  Ala Lys Val Ser Asn  Pro Leu Tyr Arg Glu  Ala Leu Leu 
    1115                 1120                 1125             


Lys Arg  Leu Gln Ala Asn Asp  Asn Asp Pro Lys Lys  Ala Phe Thr 
    1130                 1135                 1140             


Gly Lys  Asn Ala Leu Ser Lys  Asn Pro Ile Tyr Leu  Asp Glu Ala 
    1145                 1150                 1155             


Lys Thr  Lys Thr Leu Pro Glu  Lys Val Asn Leu Thr  Tyr Leu Glu 
    1160                 1165                 1170             


Glu Asp  Phe Ser Val Arg Lys  Lys Ile Val Pro Lys  Asn Pro Thr 
    1175                 1180                 1185             


Ser Lys  Glu Phe Val Pro Asn  Leu Lys Ser Ile Glu  Lys Val Val 
    1190                 1195                 1200             


Asp Glu  Gly Val Arg Asn Ile  Leu Ile Glu Arg Leu  Arg Val Tyr 
    1205                 1210                 1215             


Asn Asn  Asp Pro Glu Lys Ala  Phe Val Asp Leu Glu  Lys Asn Pro 
    1220                 1225                 1230             


Ile Trp  Leu Asn Lys Glu Lys  Gly Ile Ala Ile Lys  Arg Val Thr 
    1235                 1240                 1245             


Ile Ser  Gly Val Asn Asn Ala  Gln Pro Leu His Ile  Gly Lys Asp 
    1250                 1255                 1260             


His Leu  Gly Lys Thr Thr Leu  Asn Lys Glu Gly Lys  Glu Ile Pro 
    1265                 1270                 1275             


Val Asp  Tyr Val Ser Thr Gly  Asn Asn His His Val  Ala Ile Tyr 
    1280                 1285                 1290             


Arg Asp  Lys Glu Gly Asn Leu  Gln Glu Gln Ile Val  Ser Phe Phe 
    1295                 1300                 1305             


Glu Ala  Val Val Arg Thr Gln  Gln Gly Leu Pro Ile  Ile Asp Lys 
    1310                 1315                 1320             


Thr Tyr  Lys Gln Glu Glu Gly  Trp Gln Phe Leu Phe  Thr Met Lys 
    1325                 1330                 1335             


Gln Asn  Glu Met Phe Val Phe  Pro Asn Glu Ala Thr  Gly Phe Asn 
    1340                 1345                 1350             


Pro Ala  Glu Ile Asp Leu Leu  Asp Pro Lys Asn Lys  Lys Gln Ile 
    1355                 1360                 1365             


Ser Pro  Asn Leu Phe Arg Val  Gln Lys Ile Ala Thr  Lys Asp Tyr 
    1370                 1375                 1380             


Phe Phe  Arg His His Leu Glu  Thr Asn Val Glu Thr  Asp Asn Val 
    1385                 1390                 1395             


Leu Lys  Asn Thr Thr Trp Lys  Arg Glu Gly Leu Ser  Gly Leu Lys 
    1400                 1405                 1410             


Asp Ile  Val Lys Val Arg Ile  Asn His Leu Gly Asp  Ile Val Ser 
    1415                 1420                 1425             


Ile Gly  Glu Tyr 
    1430         


<210> 159
<211> 1450
<212> PRT
<213> Capnocytophaga sp.


<220>
<223> Capnocytophaga sp. oral taxon 412 str. F0487

<400> 159
Met Lys His Ile Leu Gly Leu Asp Leu Gly Ser Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Val Gln Gln Asp Phe Glu Asn Lys Gln Gly Lys Ile Ile Ala 
            20                  25                  30          


Thr Gly Ser Arg Ile Ile Pro Met Asp Gln Gly Ile Leu Gly Asp Phe 
        35                  40                  45              


Glu Arg Gly Asn Thr Val Ser Gln Thr Ala Glu Arg Thr Thr Tyr Arg 
    50                  55                  60                  


Asn Thr Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu His Ile Leu Gly Phe Leu Pro Pro His Tyr Asp Ser 
                85                  90                  95      


Gln Ile Asp Phe Thr Lys Arg Tyr Gly Lys Phe Ile Asp Asn Ala Glu 
            100                 105                 110         


Pro Lys Ile Ala Tyr Asn Asn Gly Asn Phe Ile Phe Met Asn Ser Phe 
        115                 120                 125             


Asn Glu Met Ile Glu Asp Phe Lys Lys Tyr Gln Pro Gln Leu Phe Tyr 
    130                 135                 140                 


Lys Lys Ser Asn Gly Glu Glu Ser Lys Ile Pro Tyr Asp Trp Thr Ile 
145                 150                 155                 160 


Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Gln Lys Ile Thr Gln Gln Glu 
                165                 170                 175     


Leu Ala Trp Leu Ile Leu His Phe Asn Gln Lys Arg Gly Tyr Tyr Gln 
            180                 185                 190         


Leu Arg Gly Glu Glu Glu Thr Glu Asn Pro Asn Lys Glu Val Ala Phe 
        195                 200                 205             


His Ser Leu Glu Val Val Asp Val Glu Ala Glu Ala Pro Asn Lys Lys 
    210                 215                 220                 


Gly Glu Ile Trp Tyr Thr Ile Arg Leu Glu Asn Gly Trp Ile Tyr Arg 
225                 230                 235                 240 


Arg Thr Ser Lys Ile Pro Leu Asp Asp Trp Lys Gly Lys Thr Arg Asp 
                245                 250                 255     


Phe Ile Val Thr Thr Asp Leu Asn Asp Asp Gly Thr Ile Lys Leu Asp 
            260                 265                 270         


Lys Glu Gly Lys Glu Lys Arg Ser Phe Arg Ala Pro Asp Glu Asn Asp 
        275                 280                 285             


Trp Asn Leu Leu Lys Lys Lys Thr Glu His Asp Ile Asp Phe Ser Gly 
    290                 295                 300                 


Lys Thr Val Gly Ala Tyr Ile Tyr Asp His Leu Leu Gln Asn Pro Asn 
305                 310                 315                 320 


Gln Lys Ile Lys Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Tyr Tyr 
                325                 330                 335     


Lys Asp Glu Leu Lys Ala Ile Leu Ala Lys Gln Ile Ala Leu Gln Pro 
            340                 345                 350         


Glu Leu Phe Thr Glu Thr Leu Leu Ala Asp Cys Ile Arg Glu Leu Tyr 
        355                 360                 365             


Arg Lys Asn Glu Thr Gln Gln Gln Asn Leu Leu Ser Lys Asp Phe Leu 
    370                 375                 380                 


His Leu Phe Val Glu Asp Ile Ile Phe Tyr Gln Arg Pro Leu Arg Ser 
385                 390                 395                 400 


Lys Lys Ser Thr Ile Ala Asn Cys Thr Leu Glu Lys Arg Ser Tyr Ile 
                405                 410                 415     


Asp Lys Glu Thr Asn Glu Arg Lys Asp Thr Pro Ile Lys Val Cys Ala 
            420                 425                 430         


Lys Ser Asn Pro Tyr Tyr Gln Glu Phe Arg Val Leu Gln Trp Leu Gln 
        435                 440                 445             


Asn Leu Arg Ile Tyr Glu Ile Glu Thr Asp Arg Glu Val Thr Ala Glu 
    450                 455                 460                 


Phe Ile Glu Thr Ala Gln Asp Asn Glu Ala Leu Phe Asn Phe Leu Met 
465                 470                 475                 480 


Ser Gln Lys Glu Ile Asp Asn Glu Ser Leu Leu Lys Tyr Phe Leu Phe 
                485                 490                 495     


Ala Lys Asn Pro Gln Ile Lys Asp Lys Val Ala Lys Ser Glu Leu Lys 
            500                 505                 510         


Lys Trp Leu Thr Thr Tyr Arg Trp Asn Tyr Val Tyr Asp Ala Ala Asp 
        515                 520                 525             


Asn Ser Ser Lys Lys Tyr Pro Met Asn Glu Thr Gly Tyr Glu Leu Gln 
    530                 535                 540                 


Gln Tyr Leu Gln Lys Val Glu Gly Leu Pro Ala Asn Phe Leu Thr Phe 
545                 550                 555                 560 


Asp Ile Thr Tyr Arg Leu Trp His Leu Leu Tyr Ser Val Lys Asp Lys 
                565                 570                 575     


Val Glu Phe Glu Lys Ala Leu Lys Lys Phe Ala Gln Glu Tyr Gln Leu 
            580                 585                 590         


Asp Glu Ala Ser Phe Val Asp Ser Phe Lys Asn Phe Lys Pro Tyr Pro 
        595                 600                 605             


Asn Glu Tyr Gly Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro 
    610                 615                 620                 


Leu Met Arg Phe Gly Asn His Trp Asp Phe Asn Arg Ile Asp Val Ser 
625                 630                 635                 640 


Thr Gln Lys Arg Ile Asp Asp Leu Ile Asn Gly Val Ala Asn Asp Glu 
                645                 650                 655     


Ile Arg Thr Ile Ile Arg Glu Lys Ala Glu Lys Tyr Gln Leu Asn Ser 
            660                 665                 670         


Glu Thr Cys Phe Gln Gly Leu Pro Leu Trp Leu Ala Gln Tyr Val Val 
        675                 680                 685             


Tyr Asn Arg His Ala Glu Ala Ala Asp Ile Glu Lys Trp Thr Ser Val 
    690                 695                 700                 


Asn Asp Leu Glu Ala Tyr Leu Glu Asp Phe Lys Gln His Ser Leu Arg 
705                 710                 715                 720 


Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val Val Arg 
                725                 730                 735     


Asp Ile Trp Gln Arg Tyr Gly Gly Gly Gln Ala Asn Phe Phe Asp Glu 
            740                 745                 750         


Ile His Ile Glu Leu Gly Arg Glu Leu Lys Lys Thr Ala Glu Glu Arg 
        755                 760                 765             


Lys Gln Leu Ser Asn Arg Asn Gln Glu Asn Glu Asn Thr Asn Leu Arg 
    770                 775                 780                 


Ile Lys Lys Leu Leu Ala Glu Leu Lys Glu Asp Ala Ser Ile Gln Asn 
785                 790                 795                 800 


Val Arg Pro Tyr Ser Pro Val Gln Gln Glu Leu Leu Lys Ile Tyr Glu 
                805                 810                 815     


Glu Gly Val Phe Ser Ala Thr Asp Glu Val Glu Glu Asp Ile Gln Lys 
            820                 825                 830         


Ile Arg Lys Lys Ala Glu Pro Thr Thr Pro Glu Ile Gln Arg Tyr Lys 
        835                 840                 845             


Leu Trp Leu Glu Gln Lys Tyr Lys Ser Pro Tyr Thr Gly Glu Val Ile 
    850                 855                 860                 


Ser Leu Thr Lys Leu Phe Thr Glu Glu Tyr Glu Ile Glu His Ile Ile 
865                 870                 875                 880 


Pro Gln Ser Arg Tyr Tyr Asp Asp Ser Leu Ser Asn Lys Val Ile Cys 
                885                 890                 895     


Glu Ser Ala Val Asn Lys Leu Lys Thr Asn Gln Leu Gly Leu Glu Phe 
            900                 905                 910         


Ile Gln Asn His His Gly Glu Lys Val Arg Ile Thr Ala Asn Lys Glu 
        915                 920                 925             


Val Thr Ile Phe Thr Glu Glu Gln Tyr Lys Glu Phe Val Lys Lys His 
    930                 935                 940                 


Tyr Ala Asn Asn Ser Ala Lys Gln Gln Lys Leu Leu Leu Asn Glu Ile 
945                 950                 955                 960 


Pro Glu Lys Met Val Ala Arg Gln Leu Asn Asp Thr Arg Tyr Ile Ser 
                965                 970                 975     


Lys Tyr Ile Ser Glu Ile Leu Ser Lys Ile Val Arg Ser Asp Glu Lys 
            980                 985                 990         


Asp Glu Gly Val Asn Ser Lys Asn  Ile Ile Pro Cys Thr  Gly Lys Ile 
        995                 1000                 1005             


Thr Thr  Ala Leu Lys Gln Asp  Trp Gly Leu Asn Asp  Val Trp Asn 
    1010                 1015                 1020             


Glu Leu  Ile Leu Pro Arg Phe  Glu Arg Met Asn Gln  Leu Thr Gln 
    1025                 1030                 1035             


Thr Gln  Leu Phe Thr Ser Tyr  Asn Asp Arg Phe Gln  Lys Asn Leu 
    1040                 1045                 1050             


Pro Thr  Val Pro Ile Glu Tyr  Ser Gln Gly Phe Gln  Lys Lys Arg 
    1055                 1060                 1065             


Ile Asp  His Arg His His Ala  Met Asp Ala Leu Val  Ile Ala Cys 
    1070                 1075                 1080             


Ala Thr  Arg Glu His Ile Asn  Tyr Met Asn Asn Gln  His Ala Leu 
    1085                 1090                 1095             


Asp Lys  Ser Lys Asp Lys Lys  Glu Lys Gln Gln Ser  Arg Ile Asp 
    1100                 1105                 1110             


Leu Arg  Thr Ile Leu Cys Glu  Lys Lys Asn Asn Asn  Trp Gln Phe 
    1115                 1120                 1125             


Lys Lys  Pro Trp Ser Thr Phe  Thr Gln Glu Ala Gln  Glu Ala Leu 
    1130                 1135                 1140             


Glu His  Ile Val Val Ser Phe  Lys Gln Asn Leu Arg  Val Ile Asn 
    1145                 1150                 1155             


Lys Ala  Thr Asn Tyr Tyr Glu  Lys Trp Glu Glu Lys  Asn Gly Val 
    1160                 1165                 1170             


Leu Val  Lys Lys Lys Val Lys  Gln Glu Gly Thr Asn  Trp Ala Ile 
    1175                 1180                 1185             


Arg Lys  Pro Leu His Lys Glu  Thr Val Ser Gly Lys  Ile Val Leu 
    1190                 1195                 1200             


Asp Arg  Lys Ile Gly Lys Asp  Lys Ile Leu Thr Ala  Thr Arg Lys 
    1205                 1210                 1215             


Ser Val  Asp Ile Thr Phe Thr  Glu Lys Ile Ile Ser  Ser Ile Thr 
    1220                 1225                 1230             


Asp Thr  Gly Ile Gln Lys Ile  Leu Leu Asn Tyr Leu  Lys Tyr Lys 
    1235                 1240                 1245             


Gly Ser  Pro Glu Val Ala Phe  Ser Ala Glu Gly Leu  Glu Glu Leu 
    1250                 1255                 1260             


Asn Lys  Asn Ile Ala Gln Tyr  Asn Asp Gly Lys Lys  His Gln Pro 
    1265                 1270                 1275             


Ile Tyr  Lys Val Arg Ile Phe  Glu Glu Gly Ser Lys  Phe Pro Leu 
    1280                 1285                 1290             


Gly Glu  Thr Gly Ala Lys Ala  Thr Lys Tyr Val Glu  Ala Ala Lys 
    1295                 1300                 1305             


Gly Thr  Asn Leu Phe Phe Gly  Val Tyr Gln Gly Lys  Gly Lys Arg 
    1310                 1315                 1320             


Thr Tyr  Ala Thr Ile Pro Leu  Asn Glu Val Ile Glu  Arg Gln Lys 
    1325                 1330                 1335             


Gln Gly  Leu Pro Ser Val Pro  Glu Arg Asn Glu Lys  Gly Glu Pro 
    1340                 1345                 1350             


Leu Leu  Phe Ser Leu Ser Pro  Asn Asp Leu Val Tyr  Val Pro Met 
    1355                 1360                 1365             


Glu Gly  Glu Ile Ala Glu Thr  Ile Asp Phe Asn Asn  Leu Ser Lys 
    1370                 1375                 1380             


Glu Gln  Lys Glu Arg Ile Tyr  Lys Thr Val Ser Phe  Thr Gly Asn 
    1385                 1390                 1395             


Gln Cys  Phe Phe Val Gln Glu  Ala Val Ala Thr Pro  Ile Val Asn 
    1400                 1405                 1410             


Lys Ile  Glu Tyr Ser Pro Leu  Asn Lys Met Glu Arg  Asp Ile Leu 
    1415                 1420                 1425             


Gly Thr  Met Ile Lys Glu Val  Cys Ile Lys Leu Lys  Val Asp Arg 
    1430                 1435                 1440             


Leu Gly  Asn Ile Thr Lys Ala  
    1445                 1450 


<210> 160
<211> 1426
<212> PRT
<213> Capnocytophaga sputigena


<220>
<223> Capnocytophaga sputigena ATCC 33612

<400> 160
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Ile Thr Ser Ile Ser Phe 
1               5                   10                  15      


Ala His Ile Val Glu Asp Glu Asn Lys Glu Lys Ser Glu Ile Lys Glu 
            20                  25                  30          


Leu Gly Val Arg Ile Val Ser Leu Thr Thr Asp Glu Gln Ser Asp Phe 
        35                  40                  45              


Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asn Arg Thr Leu Lys His 
    50                  55                  60                  


Gly Ala Arg Leu Asn Leu Asp Arg Tyr Gln Gln Arg Arg Lys Tyr Leu 
65                  70                  75                  80  


Ile Asp Leu Leu Gln Lys Ala Asn Leu Ile Thr Ser Ser Ser Ile Leu 
                85                  90                  95      


Ala Glu Asn Gly Lys Asn Thr Thr His Ser Thr Trp Gln Leu Arg Ala 
            100                 105                 110         


Lys Ala Val Thr Glu Arg Ile Glu Lys Glu Glu Phe Ala Arg Val Leu 
        115                 120                 125             


Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala Lys 
    130                 135                 140                 


Thr Glu Asp Glu Gly Gln Ala Ile Asp Gly Met Ala Ile Ala Lys Arg 
145                 150                 155                 160 


Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gln Leu Ser Leu Gln Leu Leu 
                165                 170                 175     


Gln Gln Asn Lys Lys Leu Leu Pro Asp Phe Tyr Arg Ser Asp Leu Gln 
            180                 185                 190         


Arg Glu Phe Asp Leu Val Trp Asn Phe Gln Lys Gln Phe Tyr Pro Asp 
        195                 200                 205             


Ile Leu Thr Asp Ser Phe Tyr Lys Glu Leu Gln Gly Lys Gly Lys Asp 
    210                 215                 220                 


Ala Thr Ser Lys Ala Phe Ser Lys Arg Tyr His Phe Asp Thr Ala Glu 
225                 230                 235                 240 


Asn Lys Gly Ser Lys Glu Ser Val Arg Leu Gln Ala Tyr Gln Trp Arg 
                245                 250                 255     


Ala Glu Ala Ile Ser Lys Gln Leu Ser Lys Glu Glu Val Ala Tyr Val 
            260                 265                 270         


Leu Thr Glu Ile Asn Asn Asn Leu Asn Asn Ala Ser Gly Tyr Leu Gly 
        275                 280                 285             


Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Arg Gln Thr Val 
    290                 295                 300                 


Gly Gln Tyr Leu Tyr Ala Gln Leu Gln Glu Asn Arg His Asn Ser Leu 
305                 310                 315                 320 


Lys Asn Lys Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu Arg 
                325                 330                 335     


Ile Trp Glu Thr Gln Ala Ser Phe His Lys Glu Leu Thr Asp Glu Leu 
            340                 345                 350         


Lys Lys Gln Ile Arg Asp Val Val Ile Phe Tyr Gln Arg Lys Leu Lys 
        355                 360                 365             


Ser Gln Lys Gly Leu Ile Ser Phe Cys Glu Phe Glu Ser Lys Glu Ile 
    370                 375                 380                 


Glu Ile Glu Lys Asp Gly Lys Thr Ile Thr Lys Thr Ile Gly Ala Arg 
385                 390                 395                 400 


Val Val Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln 
                405                 410                 415     


Ile Leu Asn Asn Val Thr Cys Lys Arg Lys Gly Ile Arg Lys Lys Lys 
            420                 425                 430         


Ser Ser Ala Lys Ser Thr Glu Leu Asp Leu Phe Asn Glu Pro Ser Gln 
        435                 440                 445             


Thr Ile Phe Ser Leu Asp Met Glu Cys Lys Gln Leu Leu Phe Asp Glu 
    450                 455                 460                 


Leu Asn Leu Lys Gly Asp Leu Lys Ser Asp Lys Val Leu Lys Leu Leu 
465                 470                 475                 480 


Gly Tyr Ser Pro Gln Glu Trp Glu Ile Asn Tyr Asn Gln Leu Glu Gly 
                485                 490                 495     


Asn Arg Thr Gln Lys Ala Leu Tyr Glu Ala Tyr Leu Lys Ile Val Glu 
            500                 505                 510         


Met Glu Ala His Asp Val Lys Asp Ile Leu Gln Ile Lys Ser Ala Lys 
        515                 520                 525             


Asp Asp Trp Ser Leu Asp Glu Ser Pro Leu Ser Ala Ser Glu Ile Lys 
    530                 535                 540                 


Glu Lys Val Lys Asp Ile Phe Gln Ala Leu Gly Ile Cys Thr Lys Ile 
545                 550                 555                 560 


Leu Tyr Phe Asp Pro Leu Leu Pro Val Lys Glu Phe Glu Lys Gln Asp 
                565                 570                 575     


Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asp Ser 
            580                 585                 590         


Thr Ser Gly Asn Glu Thr Leu Tyr Arg Ile Leu Glu Lys Lys Tyr Ala 
        595                 600                 605             


Phe Lys Arg Glu His Ala Arg Ile Leu Ala Asn Val Ala Leu Gln Asp 
    610                 615                 620                 


Asp Tyr Gly Ser Leu Ser Thr Lys Ala Ile Arg Lys Ile Tyr Pro Asn 
625                 630                 635                 640 


Ile Lys Glu Asn Gln Tyr Ser Lys Ala Cys Glu Leu Ala Gly Tyr Lys 
                645                 650                 655     


His Ser Lys Leu Ser Leu Thr Thr Glu Glu Leu Glu Ala Arg Glu Leu 
            660                 665                 670         


Lys Asn Ile Ile Pro Leu Leu Lys Lys Asn Ala Leu Arg Asn Pro Val 
        675                 680                 685             


Val Glu Lys Ile Leu Asn Gln Met Ile Asn Val Val Asn Ala Leu Ile 
    690                 695                 700                 


Glu Lys Asn Ser Glu Arg Asp Ala Glu Gly Lys Ile Thr Lys Tyr Phe 
705                 710                 715                 720 


His Phe Asp Glu Ile Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn 
                725                 730                 735     


Ala Gln Lys Arg Tyr Glu Met Thr Gln Asn Ile Asn Lys Ala Lys Leu 
            740                 745                 750         


Glu His Gln Lys Ile Ser Glu Ile Leu Gln Lys Lys Phe Gly Ile Lys 
        755                 760                 765             


Asn Pro Thr Lys Ser Asp Ile Ile Arg Tyr Arg Leu Tyr Gln Glu Leu 
    770                 775                 780                 


Glu His Asn Gly Tyr Lys Glu Leu Tyr Thr Asn Ala Pro Ile Ala Arg 
785                 790                 795                 800 


Asp Met Leu Phe Ser Lys Asn Ile Glu Ile Glu His Ile Val Pro Lys 
                805                 810                 815     


Ala Arg Val Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Thr Phe His 
            820                 825                 830         


Arg Ile Asn Ser Asn Lys Gly Glu Tyr Thr Ala Phe Asp Tyr Ile Thr 
        835                 840                 845             


Ser Leu Asn Ser Glu Glu Glu Leu Asn Gln Tyr Leu Thr Arg Val Glu 
    850                 855                 860                 


Asn Ala Tyr Lys Thr Lys Ser Ile Ser Leu Thr Lys Tyr Lys Asn Leu 
865                 870                 875                 880 


Leu Lys Lys Ala Ser Glu Ile Gly Asp Gly Phe Ile Asn Arg Asp Leu 
                885                 890                 895     


Arg Asp Thr Gln Tyr Ile Ala Lys Lys Ala Lys Glu Ile Leu Phe Gln 
            900                 905                 910         


Val Thr Lys Asn Val Leu Ser Thr Ser Gly Ser Ile Thr Asp Arg Leu 
        915                 920                 925             


Arg Glu Asp Trp Gly Leu Val Asp Val Met Lys Glu Leu Asn Met Pro 
    930                 935                 940                 


Lys Tyr Gln Ser Leu Gly Leu Thr Glu Val Glu Glu Arg Lys Glu Gly 
945                 950                 955                 960 


Asn Lys Val Thr Val Ile Lys Asn Trp Thr Lys Arg Asn Asp His Arg 
                965                 970                 975     


His His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Lys Pro Ser Tyr 
            980                 985                 990         


Ile Gln Tyr Leu Asn His Leu Asn  Ala Arg Lys Asp Glu  Asn Asn Lys 
        995                 1000                 1005             


Asn Tyr  Ser Val Ile Leu Ala  Ile Glu Glu Lys Glu  Thr Ile Lys 
    1010                 1015                 1020             


Val Pro  Thr Asn Asn Gly Lys  Asn Lys Arg Val Phe  Ile Glu Pro 
    1025                 1030                 1035             


Ile Pro  Asn Phe Arg Gln Val  Ala Lys Lys His Leu  Glu Glu Ile 
    1040                 1045                 1050             


Phe Ile  Ser His Lys Ala Lys  Asn Lys Val Val Thr  Lys Asn Val 
    1055                 1060                 1065             


Asn Lys  Pro Ala Gly Thr Asp  Lys Gln Gln Ile Thr  Leu Thr Pro 
    1070                 1075                 1080             


Arg Gly  Gln Leu His Lys Glu  Thr Ile Tyr Gly Lys  Tyr Gln Tyr 
    1085                 1090                 1095             


Tyr Val  Asn Lys Glu Glu Lys  Val Gly Val Lys Phe  Asp Glu Arg 
    1100                 1105                 1110             


Thr Ile  Thr Lys Val Ser Asn  Pro Leu Tyr Arg Glu  Ala Leu Leu 
    1115                 1120                 1125             


Lys Arg  Leu Gln Ala Asn Asp  Asn Asp Pro Lys Lys  Ala Phe Thr 
    1130                 1135                 1140             


Gly Lys  Asn Ala Leu Ser Lys  Asn Pro Ile Tyr Leu  Asp Glu Thr 
    1145                 1150                 1155             


Lys Thr  Lys Thr Leu Pro Glu  Lys Val Asn Leu Thr  Tyr Leu Glu 
    1160                 1165                 1170             


Glu Asp  Phe Ser Ile Arg Lys  Asp Ile Ser Pro Asp  Asn Phe Lys 
    1175                 1180                 1185             


Asp Leu  Lys Ser Ile Glu Lys  Val Ile Asp Gln Gly  Val Lys Arg 
    1190                 1195                 1200             


Ile Leu  Ile Lys Arg Leu Gln  Asp Tyr Asp Asn Asp  Pro Lys Lys 
    1205                 1210                 1215             


Ala Phe  Val Asp Leu Glu Lys  Asn Pro Ile Trp Leu  Asn Lys Glu 
    1220                 1225                 1230             


Lys Gly  Ile Ala Ile Lys Arg  Val Thr Ile Ser Gly  Val Ser Asn 
    1235                 1240                 1245             


Ala Gln  Pro Leu His Ile Gly  Lys Asp His Leu Gly  Lys Thr Thr 
    1250                 1255                 1260             


Leu Asn  Lys Glu Gly Asn Glu  Ile Pro Val Asp Tyr  Val Ser Thr 
    1265                 1270                 1275             


Gly Asn  Asn His His Val Ala  Ile Tyr Arg Asp Lys  Glu Gly Asn 
    1280                 1285                 1290             


Leu Gln  Glu Gln Ile Val Ser  Phe Phe Glu Ala Val  Val Arg Thr 
    1295                 1300                 1305             


Gln Gln  Gly Leu Pro Ile Ile  Asp Lys Thr Tyr Lys  Gln Glu Glu 
    1310                 1315                 1320             


Gly Trp  Gln Phe Leu Phe Thr  Met Lys Gln Asn Glu  Met Phe Val 
    1325                 1330                 1335             


Phe Pro  Asn Ala Thr Thr Gly  Phe Asn Pro Ala Glu  Ile Asp Leu 
    1340                 1345                 1350             


Leu Asp  Pro Lys Asn Lys Lys  Leu Ile Ser Pro Asn  Leu Phe Arg 
    1355                 1360                 1365             


Val Gln  Lys Ile Ala Thr Lys  Asp Tyr Phe Phe Arg  His His Leu 
    1370                 1375                 1380             


Glu Thr  Asn Val Glu Thr Asp  Asn Val Leu Lys Asn  Thr Thr Trp 
    1385                 1390                 1395             


Lys Arg  Glu Gly Leu Ser Gly  Leu Lys Asp Ile Val  Lys Val Arg 
    1400                 1405                 1410             


Ile Asn  His Leu Gly Asp Ile  Val Ser Ile Gly Glu  Tyr 
    1415                 1420                 1425     


<210> 161
<211> 1140
<212> PRT
<213> Catellicoccus marimammalium


<220>
<223> Catellicoccus marimammalium M35/04/3

<400> 161
Met Lys Asn Met Thr Lys Val Asn Val Gly Leu Asp Val Gly Ile Ser 
1               5                   10                  15      


Ser Ala Gly Trp Ser Val Ile Asn Ala Glu Thr Asn Gln Ile Leu Glu 
            20                  25                  30          


Ser Gly Val Arg Leu Phe Ser Gly Ser Asp Ala Asp Glu Asn Val Asn 
        35                  40                  45              


Arg Arg Asn Gln Arg Gln Gly Arg Arg Leu Phe Arg Arg Arg Lys Leu 
    50                  55                  60                  


Arg Ile Gln Glu Ala Lys Lys Tyr Leu Glu Asn Val Phe Gln Leu Lys 
65                  70                  75                  80  


Asp Ile Glu Pro Lys Asp Glu Trp Asn Pro Tyr Glu Ile Arg Val Arg 
                85                  90                  95      


Ala Leu Asn Glu Lys Val Ser Lys Glu Glu Leu Ser Ile Ala Leu Leu 
            100                 105                 110         


Asn Ile Val Lys His Arg Gly Ile Ser Tyr Glu Leu Glu Asp Val Thr 
        115                 120                 125             


Asp Glu Glu Gly Thr Asn Thr Gln Ser Phe Gln Ser Gly Leu Asp Tyr 
    130                 135                 140                 


Asn Arg Arg Leu Leu Lys Thr Lys Thr Val Gly Glu Ile Gln Tyr Asp 
145                 150                 155                 160 


Arg Leu Gln Lys Tyr Gly Gln Val Arg Gly Gln Ile Gln Thr Glu Asp 
                165                 170                 175     


Gly Leu Leu Ile Asn Ile Phe Pro Thr Lys Asn Tyr Val Glu Glu Val 
            180                 185                 190         


Glu Arg Ile Leu Glu Thr Gln Lys Lys Tyr His Pro Glu Ile Asp Asp 
        195                 200                 205             


Val Phe Ile Glu Lys Ile Ile Ser Phe Val Thr Arg Lys Arg Glu Tyr 
    210                 215                 220                 


Phe Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile Tyr 
225                 230                 235                 240 


Arg Glu Asn Gly Glu Thr Leu Asp Asn Leu Phe Glu Ile Leu Ile Gly 
                245                 250                 255     


Lys Asp Lys Phe Tyr Pro Glu Glu Tyr Arg Ala Ala Gly Ser Ser Tyr 
            260                 265                 270         


Thr Ala Gln Ile Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Pro Thr Thr Glu Asp His His Leu Thr Lys Ala Gln Lys Glu Glu Ile 
    290                 295                 300                 


Ile Thr Glu Leu Lys Asn Thr Ser Arg Leu Ser Gly Gly Met Leu Lys 
305                 310                 315                 320 


Leu Ile Ser Lys Val Thr Lys Ala Pro Lys Glu Glu Ile Ser Gly Tyr 
                325                 330                 335     


Arg Lys Asp Glu Lys Asp Lys Pro Asp Leu His Ser Leu Ala Tyr Tyr 
            340                 345                 350         


Arg Lys Gln Lys Asn Met Leu Glu Lys Glu Gly Ile Gln Ile Ala Asp 
        355                 360                 365             


Phe Ser Glu Glu Leu Leu Asp Glu Leu Ala Thr Met Met Thr Leu Asn 
    370                 375                 380                 


Thr Glu Pro Gly Glu Ile Arg Lys Gln Leu Asn Lys Ile Thr Asn Gln 
385                 390                 395                 400 


Tyr Asp Ile Leu Thr Pro Glu Val Ile Glu Val Leu Val Lys Asn His 
                405                 410                 415     


Thr Ala Phe Val Ala Thr Ser Asn His Lys Trp His Arg Phe Ser Leu 
            420                 425                 430         


Lys Leu Met Lys Glu Phe Ile Pro Glu Leu Leu Glu Thr Ser Lys Glu 
        435                 440                 445             


Gln Ser Thr Ile Leu Cys Glu Arg Gly Phe Ile Gln Asn Arg Ala Ser 
    450                 455                 460                 


Tyr Leu Asp Glu Asn His His Phe Asn Tyr Ala Glu Leu Arg Glu Asn 
465                 470                 475                 480 


Leu Tyr Asn Pro Val Val Arg Lys Ser Thr Cys Glu Met Leu Lys Val 
                485                 490                 495     


Phe Thr Ala Ile Gln Glu Lys Tyr Pro Asn Ile Gln Asn Val Ile Val 
            500                 505                 510         


Glu Leu Pro Arg Glu Thr Asn Glu Asp Glu Gln Lys Arg Lys Ile Lys 
        515                 520                 525             


Lys Ile Asn Asp Asn Asn Ala Lys Arg Lys Lys Glu Ile Leu Lys Glu 
    530                 535                 540                 


Ala Gln Ala Gln Ser Gly Leu Ser Glu Glu Ala Leu Glu Glu Lys Leu 
545                 550                 555                 560 


Leu Lys Thr Lys Gly Leu Tyr Leu Lys Leu Met Leu Trp Tyr Glu Gln 
                565                 570                 575     


Glu Gly Lys Cys Val Tyr Ser Gly Gln Glu Ile Pro Leu Ser Asp Leu 
            580                 585                 590         


Leu Gln Asn Lys Gly Gly Tyr Glu Val Asp His Ile Ile Pro Ile Ser 
        595                 600                 605             


Ile Ser Phe Asp Asp Arg Leu Cys Asn Lys Val Leu Val Arg Gln Gln 
    610                 615                 620                 


Leu Asn Ser Gln Lys Ser Asn Gln Thr Pro Phe Glu Tyr Met Thr Thr 
625                 630                 635                 640 


His Thr Asp Gly His Leu Ser Phe His Glu Leu Lys Glu Leu Val Gly 
                645                 650                 655     


Lys Asn Lys Arg Phe Ser Lys Glu Lys Arg Glu Leu Leu Leu Ala Glu 
            660                 665                 670         


Ile Tyr Ser Asn Asp Ile Glu Thr Arg Lys Arg Phe Ile Asn Arg Asn 
        675                 680                 685             


Leu Val Asp Thr Ser Tyr Thr Ala Arg Ile Val Leu Asn Ala Leu Gln 
    690                 695                 700                 


Gln Tyr Lys Lys Glu Asn Gln Leu Ser Met Asn Val Ser Val Val Arg 
705                 710                 715                 720 


Gly Ala Met Thr Asn Ile Leu Arg Lys Lys Val Lys Leu Asp Lys Thr 
                725                 730                 735     


Arg Glu Thr Phe His His His Ala Ile Asp Ala Ser Leu Met Ala Val 
            740                 745                 750         


Ile Pro Asn Ile Glu Phe Phe Lys Glu Arg Lys Glu Trp Leu Pro Lys 
        755                 760                 765             


Ser Ala Asn Glu Glu Val Val Glu Val Glu Val Ser Glu Glu Glu Thr 
    770                 775                 780                 


Met Pro Glu Lys Glu Phe Lys Val Lys Met Arg Leu Pro Glu Ser Phe 
785                 790                 795                 800 


Ile Gln Asp Val Gln Ile Leu Gln Arg Asn Ser Phe Ala Lys Glu Glu 
                805                 810                 815     


Val Ser Gly Pro Gln Thr Arg Glu Arg Asn Leu Lys Ile Lys Phe Ser 
            820                 825                 830         


His Gln Val Asp Gln Lys Met Asn Arg Lys Val Ala Asp Asp Thr Ile 
        835                 840                 845             


Tyr Gly Thr Arg Gln Ala Gln Leu Gly Lys Asp Lys Lys Glu Glu Thr 
    850                 855                 860                 


Tyr Val Ile Gly Lys Ile Lys Asp Ile Tyr Asn Tyr Asp Glu Tyr Val 
865                 870                 875                 880 


Arg Phe Lys Lys Arg Tyr Asp Lys Asn Lys Glu Ser Phe Leu Met Tyr 
                885                 890                 895     


His His Asp Pro Gln Thr Phe Glu Lys Leu Glu Glu Ile Leu Ala Gln 
            900                 905                 910         


Tyr Pro Glu Tyr Ile Glu Asp Glu Lys Gly Lys Lys Lys Lys Val Ser 
        915                 920                 925             


Pro Phe Ala Leu Tyr Arg Glu Glu Asn Gly Pro Val Thr Lys Tyr Ala 
    930                 935                 940                 


Lys Lys Asn Asn Gly Pro Val Ile Lys Gln Leu Lys Tyr Tyr Asp Ser 
945                 950                 955                 960 


Lys Leu Asn Arg Lys Ile Asp Ile Ser His Lys Tyr Ser Thr Lys Asn 
                965                 970                 975     


Arg Gln Val Val Leu Gln Ser Leu Lys Pro Tyr Arg Thr Asp Val Tyr 
            980                 985                 990         


Arg Asn Gln Asp Thr Gly Glu Tyr  Thr Leu Val Gly Ile  Asp Gln Asn 
        995                 1000                 1005             


Asp Gly  Lys Phe Val Asn Gly  His Tyr Gly Ile Pro  Lys Ser Arg 
    1010                 1015                 1020             


Tyr Glu  Glu Ile Lys Ala Asn  Asn Lys Leu Ser Glu  His Asp Glu 
    1025                 1030                 1035             


Phe Val  Phe Ser Leu Tyr Lys  Asn Ser Met Val Lys  Val Ile Asp 
    1040                 1045                 1050             


Glu Asn  Gly Glu Ser Ile Val  Val Arg Tyr Leu Ser  Arg Ser Met 
    1055                 1060                 1065             


Pro Asn  Arg Lys Asn Asn Ala  Glu Ile Lys Pro Val  Glu Lys Tyr 
    1070                 1075                 1080             


Gln Phe  Glu Asp Gly Glu Val  Val Pro Val Tyr Gly  Lys Cys Arg 
    1085                 1090                 1095             


Lys Gln  Met Gln Thr Val Phe  Val Lys Lys Gly Trp  Thr Leu Leu 
    1100                 1105                 1110             


Lys Gly  Asn Thr Asp Ile Leu  Gly Asn Thr Tyr Phe  Val Glu Lys 
    1115                 1120                 1125             


Glu Ser  Glu Asn Pro Lys Lys  Met Ile Asp Asp Lys  
    1130                 1135                 1140 


<210> 162
<211> 1329
<212> PRT
<213> Catenibacterium mitsuokai


<220>
<223> Catenibacterium mitsuokai DSM 15897

<400> 162
Ile Val Asp Tyr Cys Ile Gly Leu Asp Leu Gly Thr Gly Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Val Asp Met Asn His Arg Leu Met Lys Arg Asn Gly Lys 
            20                  25                  30          


His Leu Trp Gly Ser Arg Leu Phe Ser Asn Ala Glu Thr Ala Ala Asn 
        35                  40                  45              


Arg Arg Ala Ser Arg Ser Ile Arg Arg Arg Tyr Asn Lys Arg Arg Glu 
    50                  55                  60                  


Arg Ile Arg Leu Leu Arg Ala Ile Leu Gln Asp Met Val Leu Glu Lys 
65                  70                  75                  80  


Asp Pro Thr Phe Phe Ile Arg Leu Glu His Thr Ser Phe Leu Asp Glu 
                85                  90                  95      


Glu Asp Lys Ala Lys Tyr Leu Gly Thr Asp Tyr Lys Asp Asn Tyr Asn 
            100                 105                 110         


Leu Phe Ile Asp Glu Asp Phe Asn Asp Tyr Thr Tyr Tyr His Lys Tyr 
        115                 120                 125             


Pro Thr Ile Tyr His Leu Arg Lys Ala Leu Cys Glu Ser Thr Glu Lys 
    130                 135                 140                 


Ala Asp Pro Arg Leu Ile Tyr Leu Ala Leu His His Ile Val Lys Tyr 
145                 150                 155                 160 


Arg Gly Asn Phe Leu Tyr Glu Gly Gln Lys Phe Asn Met Asp Ala Ser 
                165                 170                 175     


Asn Ile Glu Asp Lys Leu Ser Asp Ile Phe Thr Gln Phe Thr Ser Phe 
            180                 185                 190         


Asn Asn Ile Pro Tyr Glu Asp Asp Glu Lys Lys Asn Leu Glu Ile Leu 
        195                 200                 205             


Glu Ile Leu Lys Lys Pro Leu Ser Lys Lys Ala Lys Val Asp Glu Val 
    210                 215                 220                 


Met Thr Leu Ile Ala Pro Glu Lys Asp Tyr Lys Ser Ala Phe Lys Glu 
225                 230                 235                 240 


Leu Val Thr Gly Ile Ala Gly Asn Lys Met Asn Val Thr Lys Met Ile 
                245                 250                 255     


Leu Cys Glu Pro Ile Lys Gln Gly Asp Ser Glu Ile Lys Leu Lys Phe 
            260                 265                 270         


Ser Asp Ser Asn Tyr Asp Asp Gln Phe Ser Glu Val Glu Lys Asp Leu 
        275                 280                 285             


Gly Glu Tyr Val Glu Phe Val Asp Ala Leu His Asn Val Tyr Ser Trp 
    290                 295                 300                 


Val Glu Leu Gln Thr Ile Met Gly Ala Thr His Thr Asp Asn Ala Ser 
305                 310                 315                 320 


Ile Ser Glu Ala Met Val Ser Arg Tyr Asn Lys His His Asp Asp Leu 
                325                 330                 335     


Lys Leu Leu Lys Asp Cys Ile Lys Asn Asn Val Pro Asn Lys Tyr Phe 
            340                 345                 350         


Asp Met Phe Arg Asn Asp Ser Glu Lys Ser Lys Gly Tyr Tyr Asn Tyr 
        355                 360                 365             


Ile Asn Arg Pro Ser Lys Ala Pro Val Asp Glu Phe Tyr Lys Tyr Val 
    370                 375                 380                 


Lys Lys Cys Ile Glu Lys Val Asp Thr Pro Glu Ala Lys Gln Ile Leu 
385                 390                 395                 400 


Asn Asp Ile Glu Leu Glu Asn Phe Leu Leu Lys Gln Asn Ser Arg Thr 
                405                 410                 415     


Asn Gly Ser Val Pro Tyr Gln Met Gln Leu Asp Glu Met Ile Lys Ile 
            420                 425                 430         


Ile Asp Asn Gln Ala Glu Tyr Tyr Pro Ile Leu Lys Glu Lys Arg Glu 
        435                 440                 445             


Gln Leu Leu Ser Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Phe Gly Pro 
    450                 455                 460                 


Leu Asn Glu Thr Ser Glu His Ala Trp Ile Lys Arg Leu Glu Gly Lys 
465                 470                 475                 480 


Glu Asn Gln Arg Ile Leu Pro Trp Asn Tyr Gln Asp Ile Val Asp Val 
                485                 490                 495     


Asp Ala Thr Ala Glu Gly Phe Ile Lys Arg Met Arg Ser Tyr Cys Thr 
            500                 505                 510         


Tyr Phe Pro Asp Glu Glu Val Leu Pro Lys Asn Ser Leu Ile Val Ser 
        515                 520                 525             


Lys Tyr Glu Val Tyr Asn Glu Leu Asn Lys Ile Arg Val Asp Asp Lys 
    530                 535                 540                 


Leu Leu Glu Val Asp Val Lys Asn Asp Ile Tyr Asn Glu Leu Phe Met 
545                 550                 555                 560 


Lys Asn Lys Thr Val Thr Glu Lys Lys Leu Lys Asn Trp Leu Val Asn 
                565                 570                 575     


Asn Gln Cys Cys Ser Lys Asp Ala Glu Ile Lys Gly Phe Gln Lys Glu 
            580                 585                 590         


Asn Gln Phe Ser Thr Ser Leu Thr Pro Trp Ile Asp Phe Thr Asn Ile 
        595                 600                 605             


Phe Gly Lys Ile Asp Gln Ser Asn Phe Asp Leu Ile Glu Asn Ile Ile 
    610                 615                 620                 


Tyr Asp Leu Thr Val Phe Glu Asp Lys Lys Ile Met Lys Arg Arg Leu 
625                 630                 635                 640 


Lys Lys Lys Tyr Ala Leu Pro Asp Asp Lys Val Lys Gln Ile Leu Lys 
                645                 650                 655     


Leu Lys Tyr Lys Asp Trp Ser Arg Leu Ser Lys Lys Leu Leu Asp Gly 
            660                 665                 670         


Ile Val Ala Asp Asn Arg Phe Gly Ser Ser Val Thr Val Leu Asp Val 
        675                 680                 685             


Leu Glu Met Ser Arg Leu Asn Leu Met Glu Ile Ile Asn Asp Lys Asp 
    690                 695                 700                 


Leu Gly Tyr Ala Gln Met Ile Glu Glu Ala Thr Ser Cys Pro Glu Asp 
705                 710                 715                 720 


Gly Lys Phe Thr Tyr Glu Glu Val Glu Arg Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Leu Lys Arg Gly Ile Trp Gln Ser Leu Gln Ile Val Glu Glu Ile Thr 
            740                 745                 750         


Lys Val Met Lys Cys Arg Pro Lys Tyr Ile Tyr Ile Glu Phe Glu Arg 
        755                 760                 765             


Ser Glu Glu Ala Lys Glu Arg Thr Glu Ser Lys Ile Lys Lys Leu Glu 
    770                 775                 780                 


Asn Val Tyr Lys Asp Leu Asp Glu Gln Thr Lys Lys Glu Tyr Lys Ser 
785                 790                 795                 800 


Val Leu Glu Glu Leu Lys Gly Phe Asp Asn Thr Lys Lys Ile Ser Ser 
                805                 810                 815     


Asp Ser Leu Phe Leu Tyr Phe Thr Gln Leu Gly Lys Cys Met Tyr Ser 
            820                 825                 830         


Gly Lys Lys Leu Asp Ile Asp Ser Leu Asp Lys Tyr Gln Ile Asp His 
        835                 840                 845             


Ile Val Pro Gln Ser Leu Val Lys Asp Asp Ser Phe Asp Asn Arg Val 
    850                 855                 860                 


Leu Val Val Pro Ser Glu Asn Gln Arg Lys Leu Asp Asp Leu Val Val 
865                 870                 875                 880 


Pro Phe Asp Ile Arg Asp Lys Met Tyr Arg Phe Trp Lys Leu Leu Phe 
                885                 890                 895     


Asp His Glu Leu Ile Ser Pro Lys Lys Phe Tyr Ser Leu Ile Lys Thr 
            900                 905                 910         


Glu Tyr Thr Glu Arg Asp Glu Glu Arg Phe Ile Asn Arg Gln Leu Val 
        915                 920                 925             


Glu Thr Arg Gln Ile Thr Lys Asn Val Thr Gln Ile Ile Glu Asp His 
    930                 935                 940                 


Tyr Ser Thr Thr Lys Val Ala Ala Ile Arg Ala Asn Leu Ser His Glu 
945                 950                 955                 960 


Phe Arg Val Lys Asn His Ile Tyr Lys Asn Arg Asp Ile Asn Asp Tyr 
                965                 970                 975     


His His Ala His Asp Ala Tyr Ile Val Ala Leu Ile Gly Gly Phe Met 
            980                 985                 990         


Arg Asp Arg Tyr Pro Asn Met His  Asp Ser Lys Ala Val  Tyr Ser Glu 
        995                 1000                 1005             


Tyr Met  Lys Met Phe Arg Lys  Asn Lys Asn Asp Gln  Lys Arg Trp 
    1010                 1015                 1020             


Lys Asp  Gly Phe Val Ile Asn  Ser Met Asn Tyr Pro  Tyr Glu Val 
    1025                 1030                 1035             


Asp Gly  Lys Leu Ile Trp Asn  Pro Asp Leu Ile Asn  Glu Ile Lys 
    1040                 1045                 1050             


Lys Cys  Phe Tyr Tyr Lys Asp  Cys Tyr Cys Thr Thr  Lys Leu Asp 
    1055                 1060                 1065             


Gln Lys  Ser Gly Gln Leu Phe  Asn Leu Thr Val Leu  Ser Asn Asp 
    1070                 1075                 1080             


Ala His  Ala Asp Lys Gly Val  Thr Lys Ala Val Val  Pro Val Asn 
    1085                 1090                 1095             


Lys Asn  Arg Ser Asp Val His  Lys Tyr Gly Gly Phe  Ser Gly Leu 
    1100                 1105                 1110             


Gln Tyr  Thr Ile Val Ala Ile  Glu Gly Gln Lys Lys  Lys Gly Lys 
    1115                 1120                 1125             


Lys Thr  Glu Leu Val Lys Lys  Ile Ser Gly Val Pro  Leu His Leu 
    1130                 1135                 1140             


Lys Ala  Ala Ser Ile Asn Glu  Lys Ile Asn Tyr Ile  Glu Glu Lys 
    1145                 1150                 1155             


Glu Gly  Leu Ser Asp Val Arg  Ile Ile Lys Asp Asn  Ile Pro Val 
    1160                 1165                 1170             


Asn Gln  Met Ile Glu Met Asp  Gly Gly Glu Tyr Leu  Leu Thr Ser 
    1175                 1180                 1185             


Pro Thr  Glu Tyr Val Asn Ala  Arg Gln Leu Val Leu  Asn Glu Lys 
    1190                 1195                 1200             


Gln Cys  Ala Leu Ile Ala Asp  Ile Tyr Asn Ala Ile  Tyr Lys Gln 
    1205                 1210                 1215             


Asp Tyr  Asp Asn Leu Asp Asp  Ile Leu Met Ile Gln  Leu Tyr Ile 
    1220                 1225                 1230             


Glu Leu  Thr Asn Lys Met Lys  Val Leu Tyr Pro Ala  Tyr Arg Gly 
    1235                 1240                 1245             


Ile Ala  Glu Lys Phe Glu Ser  Met Asn Glu Asn Tyr  Val Val Ile 
    1250                 1255                 1260             


Ser Lys  Glu Glu Lys Ala Asn  Ile Ile Lys Gln Met  Leu Ile Val 
    1265                 1270                 1275             


Met His  Arg Gly Pro Gln Asn  Gly Asn Ile Val Tyr  Asp Asp Phe 
    1280                 1285                 1290             


Lys Ile  Ser Asp Arg Ile Gly  Arg Leu Lys Thr Lys  Asn His Asn 
    1295                 1300                 1305             


Leu Asn  Asn Ile Val Phe Ile  Ser Gln Ser Pro Thr  Gly Ile Tyr 
    1310                 1315                 1320             


Thr Lys  Lys Tyr Lys Leu 
    1325                 


<210> 163
<211> 1419
<212> PRT
<213> Chryseobacterium sp.


<220>
<223> Chryseobacterium sp. CF314

<400> 163
Met Met Ile Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile 
1               5                   10                  15      


Gly Trp Ala Leu Ile Lys Gln Asn Phe Glu Asn Lys Tyr Gly Glu Ile 
            20                  25                  30          


Leu Gly Met Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Val Leu Gly 
        35                  40                  45              


Glu Phe Gly Lys Gly Asn Ser Val Ser Gln Thr Ala Ala Arg Thr Gly 
    50                  55                  60                  


Tyr Arg Gly Val Arg Arg Leu Arg Glu Arg Phe Leu Leu Arg Arg Glu 
65                  70                  75                  80  


Arg Leu His Arg Val Leu Asn Val Leu Asn Phe Leu Pro Glu His Tyr 
                85                  90                  95      


Ala Ser Gln Ile Asp Phe Glu Lys Arg Phe Gly Lys Phe Lys Tyr Glu 
            100                 105                 110         


Thr Glu Pro Lys Leu Ala Tyr Asn Asn Asp Gly Phe Phe Phe Lys Asn 
        115                 120                 125             


Ser Phe Asp Glu Met Leu Gly Asp Phe Lys Asp His Gln Phe His Leu 
    130                 135                 140                 


Leu Glu Asn Gly Arg Lys Val Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu 
145                 150                 155                 160 


Arg Lys Lys Ala Leu Ser Gln Lys Ile Glu Lys Glu Glu Leu Ala Trp 
                165                 170                 175     


Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg Gly 
            180                 185                 190         


Glu Asp Phe Glu Glu Glu Lys Asp Arg Val Phe Val Arg Leu Lys Val 
        195                 200                 205             


Asp Arg Val Val Asp Ser Gly Glu Asn Ile Lys Gly Lys Ile Leu Tyr 
    210                 215                 220                 


Asp Val Tyr Phe Glu Asn Gly Trp Lys Tyr Glu Lys Gln Ile Val Lys 
225                 230                 235                 240 


Thr Glu Asp Trp Ile Gly Arg Thr Lys Glu Phe Ile Val Thr Glu Ser 
                245                 250                 255     


Ile Leu Lys Asn Gly Asp Thr Lys Arg Thr Phe Lys Ala Val Asp Ser 
            260                 265                 270         


Glu Lys Asp Trp Ile Ala Ile Lys Thr Lys Thr Glu Gln Glu Ile Asp 
        275                 280                 285             


Lys Ser His Lys Thr Val Gly Ala Tyr Ile Tyr Glu Ala Leu Leu Gln 
    290                 295                 300                 


Asn Pro Lys Gln Lys Ile Lys Gly Lys Leu Val Arg Thr Ile Glu Arg 
305                 310                 315                 320 


Lys Phe Tyr Arg Glu Glu Leu Lys Lys Ile Leu Glu Arg Gln Lys Glu 
                325                 330                 335     


Phe His Pro Glu Leu Gln Ser Asp Asp Leu Tyr Asn Asp Cys Ile Arg 
            340                 345                 350         


Glu Leu Tyr Arg Asn Asn Glu Ala His Gln Ile Thr Leu Ser Lys Lys 
        355                 360                 365             


Asp Phe Val His Leu Leu Leu Asn Asp Leu Ile Phe Tyr Gln Arg Pro 
    370                 375                 380                 


Leu Arg Ser Gln Lys Ser Ser Val Ser Asn Cys Thr Leu Glu Phe Arg 
385                 390                 395                 400 


Lys Tyr Lys Asp Glu Asn Gly Val Glu His Ala Gln Tyr Leu Lys Thr 
                405                 410                 415     


Ile Pro Lys Ser Asn Pro Tyr Tyr Gln Glu Phe Arg Val Trp Gln Trp 
            420                 425                 430         


Met Phe Asn Leu Asn Ile Tyr Arg Lys Asp Asp Asp Thr Asn Val Thr 
        435                 440                 445             


Lys Glu Phe Leu Ser Ser Thr Glu Asp Tyr Glu Thr Leu Phe Glu Phe 
    450                 455                 460                 


Leu Asn Asn Arg Lys Glu Val Asp Gln Lys Ala Leu Leu Arg His Phe 
465                 470                 475                 480 


Lys Leu Asn Glu Lys Thr His Arg Trp Asn Tyr Val Glu Asp Lys Lys 
                485                 490                 495     


Tyr Pro Cys Asn Glu Thr Lys Thr Met Ile Ser Thr Arg Leu Glu Lys 
            500                 505                 510         


Val Glu Asn Tyr Pro Ser Asp Phe Leu Thr Arg Glu Met Glu Gln Asn 
        515                 520                 525             


Ile Trp His Ile Ile Tyr Ser Val Asn Asp Lys Ile Glu Tyr Glu Lys 
    530                 535                 540                 


Ala Leu Lys Ser Phe Ala His Lys Asn Asn Leu Asp Glu Asn Ser Phe 
545                 550                 555                 560 


Phe Glu Ala Phe Lys Lys Phe Pro Pro Phe Lys Ser Glu Tyr Gly Ser 
                565                 570                 575     


Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro Leu Leu Arg Leu Gly 
            580                 585                 590         


Lys Tyr Trp Asn Trp Glu Ser Ile Asp Arg Lys Ser Gln Gly Arg Ile 
        595                 600                 605             


Glu Lys Ile Ile Thr Gly Glu Phe Asp Gly Asn Ile Lys Asp Lys Val 
    610                 615                 620                 


Arg Glu Lys Ala Ile His Leu Thr Ala Glu Asn Asp Phe Gln Gly Leu 
625                 630                 635                 640 


Gln Leu Trp Leu Ala Gln Tyr Ile Val Tyr Gly Arg His Ser Glu Ala 
                645                 650                 655     


Ser Met Ile Gly Lys Trp Asn Ser Ala Asp Asp Leu Glu Glu Phe Leu 
            660                 665                 670         


Lys Gly Phe Lys Gln His Ser Leu Arg Asn Pro Ile Val Glu Gln Val 
        675                 680                 685             


Ile Thr Glu Thr Leu Arg Val Val Lys Asp Ile Trp Leu Lys Tyr Gly 
    690                 695                 700                 


Asn Gly Ala Lys Asp Phe Phe Ser Glu Ile His Ile Glu Leu Gly Arg 
705                 710                 715                 720 


Glu Met Lys Gln Thr Lys Asp Glu Arg Val Asp Ala Thr Lys Arg Ile 
                725                 730                 735     


Thr Glu Asn Glu Asn Thr Asn Leu Arg Ile Lys Ala Leu Leu Ala Glu 
            740                 745                 750         


Met Met Asn Asp Asn Ser Val Glu Asn Ile Arg Pro Tyr Ser Pro Met 
        755                 760                 765             


Gln Gln Glu Ile Leu Lys Ile Tyr Glu Asp Gly Ile Leu Lys Ser Asp 
    770                 775                 780                 


Ile Glu Ile Asp Asp Asp Ile Leu Lys Ile Ser Lys Thr Ala Gln Pro 
785                 790                 795                 800 


Ser Ser Ser Asp Leu Lys Arg Tyr Lys Leu Trp Leu Glu Gln Arg Tyr 
                805                 810                 815     


Lys Ser Pro Tyr Thr Gly Gln Ile Ile Pro Leu Asn Lys Leu Phe Thr 
            820                 825                 830         


Ser Glu Tyr Glu Ile Glu His Ile Ile Pro Gln Ser Arg Tyr Phe Asp 
        835                 840                 845             


Asp Ser Phe Ser Asn Lys Ile Ile Cys Glu Ser Ala Val Asn Lys Leu 
    850                 855                 860                 


Lys Asp Asn Tyr Ile Gly Leu Gly Phe Ile Lys Gln Phe Gly Gly Met 
865                 870                 875                 880 


Ile Val Glu Cys Gly Phe Gly Lys Ser Val Glu Ile Phe Lys Ala Glu 
                885                 890                 895     


Glu Tyr Glu Asp Phe Val Lys Lys His Tyr Ala Asn Asn Arg Ser Lys 
            900                 905                 910         


Arg Asn Lys Leu Leu Leu Glu Glu Ile Pro Glu Lys Met Ile Asp Arg 
        915                 920                 925             


Gln Leu Asn Asp Thr Arg His Ile Ser Lys Tyr Ile Ser Gly Val Leu 
    930                 935                 940                 


Ser Asn Ile Val Arg Gln Glu Asp Gly Thr Asp Glu Gly Val Asn Ser 
945                 950                 955                 960 


Lys Asn Ile Val Pro Gly Asn Gly Lys Ile Thr Thr Gln Leu Lys Gln 
                965                 970                 975     


Asp Trp Gly Leu Asn Asp Val Trp Asn Glu Leu Ile Leu Pro Arg Phe 
            980                 985                 990         


Glu Arg Met Asn Gln Leu Thr Asn  Ser Thr Asp Phe Thr  Ser Trp Asn 
        995                 1000                 1005             


Lys Asn  His Gln Lys Phe Leu  Pro Thr Val Pro Ile  Glu Phe Ser 
    1010                 1015                 1020             


Lys Gly  Phe Ser Lys Lys Arg  Ile Asp His Arg His  His Ala Met 
    1025                 1030                 1035             


Asp Ala  Leu Val Ile Ala Cys  Ala Thr Lys Asp His  Ile Asn Leu 
    1040                 1045                 1050             


Leu Asn  Asn Gln Ser Ala Lys  Ser Asp Thr Lys Arg  Tyr Asp Leu 
    1055                 1060                 1065             


Lys Arg  Lys Leu Met Lys Phe  Glu Arg Val Val Tyr  Ser His Ser 
    1070                 1075                 1080             


Lys Thr  Gly Glu Lys Ile Glu  Lys Glu Val Pro Lys  Gln Phe Leu 
    1085                 1090                 1095             


Lys Pro  Trp Asp Asn Phe Thr  Val Asp Ala Lys Asn  Lys Met Glu 
    1100                 1105                 1110             


Thr Ile  Ile Val Ser Phe Lys  Gln Asn Leu Arg Val  Ile Asn Lys 
    1115                 1120                 1125             


Ala Thr  Asn His Tyr Glu Lys  Trp Ile Glu Lys Asp  Gly Ile Lys 
    1130                 1135                 1140             


Arg Lys  Glu Leu Ile Lys Gln  Glu Gly Thr Asn Trp  Ala Ile Arg 
    1145                 1150                 1155             


Lys Pro  Met His Lys Glu Thr  Val Ser Gly Lys Val  Asp Leu Pro 
    1160                 1165                 1170             


Gly Ile  Lys Ile Pro Lys Gly  Lys Ile Leu Thr Ala  Thr Arg Lys 
    1175                 1180                 1185             


Ser Leu  Asp Thr Ser Phe Asp  Leu Lys Thr Ile Asn  Ser Ile Thr 
    1190                 1195                 1200             


Asp Thr  Gly Ile Gln Lys Ile  Leu Lys Asn Tyr Leu  Glu Phe Lys 
    1205                 1210                 1215             


Gly Ser  Ser Glu Leu Ala Phe  Ser Pro Glu Gly Ile  Glu Asp Met 
    1220                 1225                 1230             


Asn Lys  Asn Ile Glu Lys Phe  Asn Asp Gly Lys Pro  His Gln Ser 
    1235                 1240                 1245             


Ile Asn  Lys Val Arg Ile Phe  Glu Leu Gly Ser Lys  Phe Ser Val 
    1250                 1255                 1260             


Gly Gln  Thr Gly Asn Lys Lys  Asp Lys Tyr Val Glu  Ala Ala Lys 
    1265                 1270                 1275             


Gly Thr  Asn Leu Phe Phe Ala  Val Tyr Glu Asp Lys  Asn Gly Lys 
    1280                 1285                 1290             


Arg Ser  Tyr Glu Thr Ile Pro  Leu Asn Glu Val Ile  Glu Arg Gln 
    1295                 1300                 1305             


Lys Gln  Gly Leu Asp Ser Val  Ser Phe Lys Asn Lys  Glu Asp Phe 
    1310                 1315                 1320             


Leu Leu  Cys Pro Asn Asp Leu  Val Tyr Val Pro Ser  Glu Asp Glu 
    1325                 1330                 1335             


Leu Glu  Asn Ile Tyr Asn Ile  Asp Phe Lys Asn Leu  Thr Thr Glu 
    1340                 1345                 1350             


Lys Thr  Gly Asn Ile Tyr Lys  Val Val Ser Phe Ser  Gly Asn Gln 
    1355                 1360                 1365             


Ile Phe  Phe Ile Arg Gln Asp  Ile Ala Ile Ser Ile  Val Asn Lys 
    1370                 1375                 1380             


Ala Glu  Phe Ser Thr Leu Asn  Lys Met Glu Arg Ala  Ile Asp Gly 
    1385                 1390                 1395             


Ser Met  Ile Lys Glu Asn Cys  Ile Lys Leu Lys Ile  Asp Arg Leu 
    1400                 1405                 1410             


Gly Asn  Ile Ala Lys Ile 
    1415                 


<210> 164
<211> 1021
<212> PRT
<213> Clostridium cellulolyticum

<400> 164
Met Lys Tyr Thr Leu Gly Leu Asp Val Gly Ile Ala Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Ile Asp Lys Asp Asn Asn Lys Ile Ile Asp Leu Gly Val Arg 
            20                  25                  30          


Cys Phe Asp Lys Ala Glu Glu Ser Lys Thr Gly Glu Ser Leu Ala Thr 
        35                  40                  45              


Ala Arg Arg Ile Ala Arg Gly Met Arg Arg Arg Ile Ser Arg Arg Ser 
    50                  55                  60                  


Gln Arg Leu Arg Leu Val Lys Lys Leu Phe Val Gln Tyr Glu Ile Ile 
65                  70                  75                  80  


Lys Asp Ser Ser Glu Phe Asn Arg Ile Phe Asp Thr Ser Arg Asp Gly 
                85                  90                  95      


Trp Lys Asp Pro Trp Glu Leu Arg Tyr Asn Ala Leu Ser Arg Ile Leu 
            100                 105                 110         


Lys Pro Tyr Glu Leu Val Gln Val Leu Thr His Ile Thr Lys Arg Arg 
        115                 120                 125             


Gly Phe Lys Ser Asn Arg Lys Glu Asp Leu Ser Thr Thr Lys Glu Gly 
    130                 135                 140                 


Val Val Ile Thr Ser Ile Lys Asn Asn Ser Glu Met Leu Arg Thr Lys 
145                 150                 155                 160 


Asn Tyr Arg Thr Ile Gly Glu Met Ile Phe Met Glu Thr Pro Glu Asn 
                165                 170                 175     


Ser Asn Lys Arg Asn Lys Val Asp Glu Tyr Ile His Thr Ile Ala Arg 
            180                 185                 190         


Glu Asp Leu Leu Asn Glu Ile Lys Tyr Ile Phe Ser Ile Gln Arg Lys 
        195                 200                 205             


Leu Gly Ser Pro Phe Val Thr Glu Lys Leu Glu His Asp Phe Leu Asn 
    210                 215                 220                 


Ile Trp Glu Phe Gln Arg Pro Phe Ala Ser Gly Asp Ser Ile Leu Ser 
225                 230                 235                 240 


Lys Val Gly Lys Cys Thr Leu Leu Lys Glu Glu Leu Arg Ala Pro Thr 
                245                 250                 255     


Ser Cys Tyr Thr Ser Glu Tyr Phe Gly Leu Leu Gln Ser Ile Asn Asn 
            260                 265                 270         


Leu Val Leu Val Glu Asp Asn Asn Thr Leu Thr Leu Asn Asn Asp Gln 
        275                 280                 285             


Arg Ala Lys Ile Ile Glu Tyr Ala His Phe Lys Asn Glu Ile Lys Tyr 
    290                 295                 300                 


Ser Glu Ile Arg Lys Leu Leu Asp Ile Glu Pro Glu Ile Leu Phe Lys 
305                 310                 315                 320 


Ala His Asn Leu Thr His Lys Asn Pro Ser Gly Asn Asn Glu Ser Lys 
                325                 330                 335     


Lys Phe Tyr Glu Met Lys Ser Tyr His Lys Leu Lys Ser Thr Leu Pro 
            340                 345                 350         


Thr Asp Ile Trp Gly Lys Leu His Ser Asn Lys Glu Ser Leu Asp Asn 
        355                 360                 365             


Leu Phe Tyr Cys Leu Thr Val Tyr Lys Asn Asp Asn Glu Ile Lys Asp 
    370                 375                 380                 


Tyr Leu Gln Ala Asn Asn Leu Asp Tyr Leu Ile Glu Tyr Ile Ala Lys 
385                 390                 395                 400 


Leu Pro Thr Phe Asn Lys Phe Lys His Leu Ser Leu Val Ala Met Lys 
                405                 410                 415     


Arg Ile Ile Pro Phe Met Glu Lys Gly Tyr Lys Tyr Ser Asp Ala Cys 
            420                 425                 430         


Asn Met Ala Glu Leu Asp Phe Thr Gly Ser Ser Lys Leu Glu Lys Cys 
        435                 440                 445             


Asn Lys Leu Thr Val Glu Pro Ile Ile Glu Asn Val Thr Asn Pro Val 
    450                 455                 460                 


Val Ile Arg Ala Leu Thr Gln Ala Arg Lys Val Ile Asn Ala Ile Ile 
465                 470                 475                 480 


Gln Lys Tyr Gly Leu Pro Tyr Met Val Asn Ile Glu Leu Ala Arg Glu 
                485                 490                 495     


Ala Gly Met Thr Arg Gln Asp Arg Asp Asn Leu Lys Lys Glu His Glu 
            500                 505                 510         


Asn Asn Arg Lys Ala Arg Glu Lys Ile Ser Asp Leu Ile Arg Gln Asn 
        515                 520                 525             


Gly Arg Val Ala Ser Gly Leu Asp Ile Leu Lys Trp Arg Leu Trp Glu 
    530                 535                 540                 


Asp Gln Gly Gly Arg Cys Ala Tyr Ser Gly Lys Pro Ile Pro Val Cys 
545                 550                 555                 560 


Asp Leu Leu Asn Asp Ser Leu Thr Gln Ile Asp His Ile Tyr Pro Tyr 
                565                 570                 575     


Ser Arg Ser Met Asp Asp Ser Tyr Met Asn Lys Val Leu Val Leu Thr 
            580                 585                 590         


Asp Glu Asn Gln Asn Lys Arg Ser Tyr Thr Pro Tyr Glu Val Trp Gly 
        595                 600                 605             


Ser Thr Glu Lys Trp Glu Asp Phe Glu Ala Arg Ile Tyr Ser Met His 
    610                 615                 620                 


Leu Pro Gln Ser Lys Glu Lys Arg Leu Leu Asn Arg Asn Phe Ile Thr 
625                 630                 635                 640 


Lys Asp Leu Asp Ser Phe Ile Ser Arg Asn Leu Asn Asp Thr Arg Tyr 
                645                 650                 655     


Ile Ser Arg Phe Leu Lys Asn Tyr Ile Glu Ser Tyr Leu Gln Phe Ser 
            660                 665                 670         


Asn Asp Ser Pro Lys Ser Cys Val Val Cys Val Asn Gly Gln Cys Thr 
        675                 680                 685             


Ala Gln Leu Arg Ser Arg Trp Gly Leu Asn Lys Asn Arg Glu Glu Ser 
    690                 695                 700                 


Asp Leu His His Ala Leu Asp Ala Ala Val Ile Ala Cys Ala Asp Arg 
705                 710                 715                 720 


Lys Ile Ile Lys Glu Ile Thr Asn Tyr Tyr Asn Glu Arg Glu Asn His 
                725                 730                 735     


Asn Tyr Lys Val Lys Tyr Pro Leu Pro Trp His Ser Phe Arg Gln Asp 
            740                 745                 750         


Leu Met Glu Thr Leu Ala Gly Val Phe Ile Ser Arg Ala Pro Arg Arg 
        755                 760                 765             


Lys Ile Thr Gly Pro Ala His Asp Glu Thr Ile Arg Ser Pro Lys His 
    770                 775                 780                 


Phe Asn Lys Gly Leu Thr Ser Val Lys Ile Pro Leu Thr Thr Val Thr 
785                 790                 795                 800 


Leu Glu Lys Leu Glu Thr Met Val Lys Asn Thr Lys Gly Gly Ile Ser 
                805                 810                 815     


Asp Lys Ala Val Tyr Asn Val Leu Lys Asn Arg Leu Ile Glu His Asn 
            820                 825                 830         


Asn Lys Pro Leu Lys Ala Phe Ala Glu Lys Ile Tyr Lys Pro Leu Lys 
        835                 840                 845             


Asn Gly Thr Asn Gly Ala Ile Ile Arg Ser Ile Arg Val Glu Thr Pro 
    850                 855                 860                 


Ser Tyr Thr Gly Val Phe Arg Asn Glu Gly Lys Gly Ile Ser Asp Asn 
865                 870                 875                 880 


Ser Leu Met Val Arg Val Asp Val Phe Lys Lys Lys Asp Lys Tyr Tyr 
                885                 890                 895     


Leu Val Pro Ile Tyr Val Ala His Met Ile Lys Lys Glu Leu Pro Ser 
            900                 905                 910         


Lys Ala Ile Val Pro Leu Lys Pro Glu Ser Gln Trp Glu Leu Ile Asp 
        915                 920                 925             


Ser Thr His Glu Phe Leu Phe Ser Leu Tyr Gln Asn Asp Tyr Leu Val 
    930                 935                 940                 


Ile Lys Thr Lys Lys Gly Ile Thr Glu Gly Tyr Tyr Arg Ser Cys His 
945                 950                 955                 960 


Arg Gly Thr Gly Ser Leu Ser Leu Met Pro His Phe Ala Asn Asn Lys 
                965                 970                 975     


Asn Val Lys Ile Asp Ile Gly Val Arg Thr Ala Ile Ser Ile Glu Lys 
            980                 985                 990         


Tyr Asn Val Asp Ile Leu Gly Asn  Lys Ser Ile Val Lys  Gly Glu Pro 
        995                 1000                 1005             


Arg Arg  Gly Met Glu Lys Tyr  Asn Ser Phe Lys Ser  Asn 
    1010                 1015                 1020     


<210> 165
<211> 1065
<212> PRT
<213> Clostridium perfringens


<220>
<223> Clostridium perfringens C str. JGS1495

<400> 165
Met Asn Lys Asp Ile Asn Tyr Ala Leu Gly Leu Asp Ile Gly Ile Thr 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Ile Asn Leu Asp Leu Asn Arg Ile Glu Asp 
            20                  25                  30          


Leu Gly Val Arg Ile Phe Asn Ala Ala Glu Asn Pro Lys Asp Gly Ser 
        35                  40                  45              


Ser Leu Ala Leu Pro Arg Arg Leu Ala Arg Gly Arg Arg Arg Leu Leu 
    50                  55                  60                  


Arg Arg Lys Ala Tyr Arg Val Glu Arg Val Arg Lys Leu Ile Val Lys 
65                  70                  75                  80  


Asn Asn Ile Leu Thr Lys Glu Glu Leu Glu Gly Leu Phe Lys Asn Lys 
                85                  90                  95      


Glu Val Ile Asp Val Trp Glu Ala Arg Val Lys Gly Leu Asp Tyr Lys 
            100                 105                 110         


Leu Ser Arg Glu Glu Trp Ala Lys Ile Leu Ile Asn Phe Cys Lys Arg 
        115                 120                 125             


Arg Gly Phe Lys Ser Asn Arg Lys Asn Glu Thr Lys Asp Lys Glu Ala 
    130                 135                 140                 


Gly Gln Ile Leu Ser Ser Ile Ser Tyr Asn Ile Glu Lys Met Lys Glu 
145                 150                 155                 160 


Thr Asn Ser Arg Thr Ile Gly Glu Tyr Ile Tyr Asn Glu Val Lys Asn 
                165                 170                 175     


Ser Asp Asp Ser Tyr Ala Pro Leu Arg Asn Lys Phe Gly Glu Tyr Lys 
            180                 185                 190         


Met Cys Val Ser Arg Asp Val Leu Arg Glu Glu Ile His Thr Leu Phe 
        195                 200                 205             


Glu Lys Gln Arg Glu Leu Gly Asn Asn Phe Ala Ser Asp Glu Ile Glu 
    210                 215                 220                 


Asp Lys Tyr Phe Glu Ile Phe Asn Ser Gln Arg Pro Phe Ser Asn Phe 
225                 230                 235                 240 


Glu Asp Leu Glu Lys Leu Val Gly Phe Cys Thr Phe Glu Arg Lys Lys 
                245                 250                 255     


His Lys Arg Ala Pro Lys His Cys Ile Ser Ser Glu Glu Phe Thr Leu 
            260                 265                 270         


Tyr Glu Gly Ile Asn Lys Leu Ser Ile Ile Lys Asp Gly Glu Lys Arg 
        275                 280                 285             


Lys Leu Ser Glu Glu Glu Arg Thr Leu Val Val Asn Glu Ala Phe Asn 
    290                 295                 300                 


Lys Lys Glu Ile Lys Tyr Thr Thr Leu Arg Lys Leu Leu Gly Leu Ser 
305                 310                 315                 320 


Glu Asp Glu Leu Phe Ser Thr Leu Thr Tyr Ser Ile Asp Lys Asp Ile 
                325                 330                 335     


Ser Lys Thr Glu Asn Thr Lys Phe Val Ser Leu Lys Gly Tyr His Glu 
            340                 345                 350         


Ile Lys Arg Ala Ile Glu Lys Gly Val Ser Lys Lys Ala Trp Gln Asp 
        355                 360                 365             


Ile Glu Asn Asn Arg Asn Leu Leu Asn Asp Ile Ala Tyr Val Leu Thr 
    370                 375                 380                 


Leu Gly Lys Thr Asp Asp Glu Ile Glu Lys Gln Leu Arg Leu Arg Asn 
385                 390                 395                 400 


Val Pro Glu Glu Leu Phe Glu Ser Leu Leu Asp Met Ser Phe Ser Lys 
                405                 410                 415     


Phe Asn Asn Leu Ser Ile Tyr Ala Leu Glu Lys Ile Leu Pro Phe Met 
            420                 425                 430         


Lys Glu Gly Tyr Gln Tyr Asn Glu Ala Cys Glu Lys Ala Gly Tyr Asn 
        435                 440                 445             


Phe Lys Ala Ile Tyr Glu Gly Val Arg Thr Lys Lys Leu Pro Val Ile 
    450                 455                 460                 


Glu Ile Asp Glu Ile Val Asn Pro Val Val Asn Arg Ala Leu Ala Gln 
465                 470                 475                 480 


Thr Arg Lys Val Ile Asn Ser Val Ile Asp Lys Tyr Gly Ser Pro Val 
                485                 490                 495     


Arg Ile Asn Ile Glu Leu Ala Arg Asp Leu Ala Lys Asn Phe Lys Asp 
            500                 505                 510         


Arg Lys Leu Ile Glu Lys Glu Gln Lys Glu Asn Arg Ala Asn Leu Asp 
        515                 520                 525             


Lys Ile Arg Glu Asn Leu Arg Glu Leu Met Asp Lys Glu Pro Thr Ala 
    530                 535                 540                 


Val Glu Val Leu Lys Tyr Arg Leu Trp Glu Gln Gln Arg Gly Glu Cys 
545                 550                 555                 560 


Ala Tyr Thr Gln Ser Gln Ile Ala Leu Glu Arg Leu Phe Ser Pro Gly 
                565                 570                 575     


Tyr Cys Glu Ile Asp His Ile Ile Pro Phe Ser Arg Ser Phe Asp Asp 
            580                 585                 590         


Ser Leu Ser Asn Lys Ile Leu Val Leu Gly Ser Glu Asn Gln Arg Lys 
        595                 600                 605             


Gly Asn Lys Ile Pro Tyr Glu Tyr Phe Gly Glu Asp Ser Glu Arg Trp 
    610                 615                 620                 


Asn Ser Phe Glu Ile Trp Val Lys Gly Ser Tyr Leu Asn Tyr Lys Lys 
625                 630                 635                 640 


Lys Ala Asn Leu Leu Lys Lys Lys Phe Thr Glu Glu Glu Gln Arg Asp 
                645                 650                 655     


Trp Lys Ala Arg Asn Leu Gln Asp Thr Lys Tyr Ile Cys Arg Tyr Ile 
            660                 665                 670         


Ser Asn Phe Val Asn Asn Arg Leu Glu Phe Lys Glu Ser Glu Asn Lys 
        675                 680                 685             


Gln Lys Val Ile Thr Val Asn Gly Arg Ala Thr Ala Tyr Leu Arg Ser 
    690                 695                 700                 


Arg Trp Gly Leu Asn Lys Val Arg Glu Asp Gly Asp Lys His His Ala 
705                 710                 715                 720 


Leu Asp Ala Ala Val Val Gly Val Thr Thr Gln Gly Met Val Gln Lys 
                725                 730                 735     


Ile Ser Lys Tyr Ser Lys Ala His Glu Leu Tyr Thr Val Arg Lys Asn 
            740                 745                 750         


Asp Glu Phe Val Asp Val Glu Thr Gly Glu Cys Val Asp Val Asp Glu 
        755                 760                 765             


Tyr Lys Glu Ile Arg Lys Asp Ile Leu Pro Arg Pro Trp Arg Gly Phe 
    770                 775                 780                 


Ser Glu Glu Leu Lys Leu Arg Leu Ser Asp Asn Pro Leu Glu Glu Leu 
785                 790                 795                 800 


Lys Lys Leu Pro Ile Glu Thr Tyr Asn Glu Glu Phe Ile Lys Glu Asn 
                805                 810                 815     


Val Lys Pro Ile Phe Val Ser Arg Val Pro Phe Arg Lys Ile Ser Gly 
            820                 825                 830         


Lys Leu Phe Lys Glu Thr Ile Tyr Ser Glu Arg Ala Phe Lys Asp Gly 
        835                 840                 845             


Tyr Phe Val Ser Lys Lys Ser Leu Val Asp Leu Lys Arg Gly Asp Leu 
    850                 855                 860                 


Asp Asn Phe Tyr Asn Tyr Glu Cys Asp Lys Lys Leu Tyr Asp Ala Ile 
865                 870                 875                 880 


Ser Glu Arg Met Lys Glu Phe Asn Tyr Asn Gly Lys Lys Ala Phe Glu 
                885                 890                 895     


Ser Pro Phe Arg Lys Pro Thr Lys Ser Gly Lys Glu Gly Pro Val Val 
            900                 905                 910         


Arg Ser Val Lys Ile Lys Ser Ala Ala Pro Phe Lys Asp Gly Ile Pro 
        915                 920                 925             


Met Asn Glu Gly Leu Val Ala Lys Glu Gly Met Val Arg Ile Asp Ile 
    930                 935                 940                 


Tyr Glu Lys Glu Gly Lys Tyr Phe Val Val Pro Val Tyr Arg Tyr Gln 
945                 950                 955                 960 


Leu Ala Lys Gly Ile Val Pro Lys Arg Ala Ala Ile Ala Gly Lys Ser 
                965                 970                 975     


Glu Leu Lys Trp Pro Ile Met Asp Gln Thr Tyr Asn Phe Lys Phe Ser 
            980                 985                 990         


Ile Phe Lys Asn Asp Leu Ile Glu  Ile Lys Tyr Ala Lys  Lys Asp Gly 
        995                 1000                 1005             


Tyr Phe  Gly Tyr Tyr Asp Gly  Phe Asp Arg His Thr  Ala Ser Leu 
    1010                 1015                 1020             


Val Ile  Glu Asn His Asp Asn  Ser Asp Arg Tyr Arg  Gly Ile Gly 
    1025                 1030                 1035             


Val Lys  Thr Gly Val Val Glu  Phe Asn Lys Tyr Glu  Val Asp Val 
    1040                 1045                 1050             


Leu Gly  Asn Tyr His Lys Val  Asn Leu Gly Gly Asn  
    1055                 1060                 1065 


<210> 166
<211> 1065
<212> PRT
<213> Clostridium perfringens


<220>
<223> Clostridium perfringens D str. JGS1721

<400> 166
Met Asn Lys Asp Ile Asn Tyr Ala Leu Gly Leu Asp Ile Gly Ile Thr 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Ile Asn Leu Asp Leu Asn Arg Ile Glu Asp 
            20                  25                  30          


Leu Gly Val Arg Ile Phe Asn Ala Ala Glu Asn Leu Lys Asp Gly Ser 
        35                  40                  45              


Ser Leu Ala Leu Pro Arg Arg Leu Ala Arg Gly Arg Arg Arg Leu Leu 
    50                  55                  60                  


Arg Arg Lys Ala Tyr Arg Val Glu Arg Val Arg Lys Leu Ile Leu Lys 
65                  70                  75                  80  


Asn Asn Ile Leu Thr Lys Glu Glu Leu Glu Gly Leu Phe Lys Asn Lys 
                85                  90                  95      


Glu Val Ile Asp Val Trp Glu Ala Arg Val Lys Gly Leu Asp Tyr Lys 
            100                 105                 110         


Leu Ser Arg Glu Glu Trp Ala Lys Ile Leu Ile Asn Phe Cys Lys Arg 
        115                 120                 125             


Arg Gly Phe Lys Ser Asn Arg Lys Asn Glu Ala Lys Asp Lys Glu Ala 
    130                 135                 140                 


Gly Gln Ile Leu Ser Ser Ile Ser Tyr Asn Ile Glu Lys Met Lys Glu 
145                 150                 155                 160 


Thr Asn Ser Arg Thr Ile Gly Glu Tyr Ile Tyr Asn Glu Val Lys Asn 
                165                 170                 175     


Ser Glu Asp Ser Tyr Ala Pro Leu Arg Asn Lys Phe Gly Glu Tyr Lys 
            180                 185                 190         


Met Cys Val Ser Arg Asp Val Ile Arg Glu Glu Ile His Thr Leu Phe 
        195                 200                 205             


Glu Lys Gln Arg Glu Leu Gly Asn Asn Phe Ala Ser Asp Glu Ile Glu 
    210                 215                 220                 


Asp Lys Tyr Phe Glu Ile Phe Asn Ser Gln Arg Pro Phe Ser Asn Phe 
225                 230                 235                 240 


Glu Asp Leu Glu Lys Leu Val Gly Phe Cys Thr Phe Glu Arg Lys Lys 
                245                 250                 255     


His Lys Arg Ala Pro Lys His Cys Ile Ser Ser Glu Glu Phe Thr Leu 
            260                 265                 270         


Tyr Glu Gly Ile Asn Lys Leu Ser Ile Ile Lys Asp Gly Glu Lys Arg 
        275                 280                 285             


Lys Leu Ser Glu Glu Glu Arg Thr Leu Val Val Asn Glu Ala Phe Asn 
    290                 295                 300                 


Lys Lys Glu Ile Lys Tyr Thr Thr Leu Arg Lys Leu Leu Gly Leu Ser 
305                 310                 315                 320 


Glu Glu Glu Leu Phe Ser Thr Leu Thr Tyr Ser Ile Asp Lys Asp Ile 
                325                 330                 335     


Ser Lys Thr Glu Asn Thr Lys Phe Val Ser Leu Lys Gly Tyr His Glu 
            340                 345                 350         


Ile Lys Arg Ala Ile Glu Lys Gly Val Ser Lys Lys Ala Trp Gln Asp 
        355                 360                 365             


Ile Glu Asn Asn Arg Asn Leu Leu Asn Asp Ile Ala Tyr Val Leu Thr 
    370                 375                 380                 


Leu Gly Lys Thr Asp Asp Glu Ile Glu Lys Gln Leu Arg Leu Arg Asn 
385                 390                 395                 400 


Val Pro Glu Glu Leu Phe Glu Ser Leu Leu Asp Met Ser Phe Asn Lys 
                405                 410                 415     


Phe Asn Asn Leu Ser Ile Tyr Ala Leu Glu Lys Ile Leu Pro Phe Met 
            420                 425                 430         


Lys Glu Gly Tyr Gln Tyr Asn Glu Ala Cys Glu Lys Ala Gly Tyr Asn 
        435                 440                 445             


Phe Lys Ala Ile Tyr Glu Gly Val Arg Thr Lys Lys Leu Pro Val Ile 
    450                 455                 460                 


Glu Ile Asp Glu Ile Val Asn Pro Val Val Asn Arg Ala Leu Ala Gln 
465                 470                 475                 480 


Thr Arg Lys Val Ile Asn Ser Val Ile Asp Lys Tyr Gly Ser Pro Val 
                485                 490                 495     


Arg Ile Asn Ile Glu Leu Ala Arg Asp Leu Ala Lys Asn Phe Lys Asp 
            500                 505                 510         


Arg Lys Leu Ile Glu Lys Glu Gln Lys Glu Asn Arg Ala Asn Leu Asp 
        515                 520                 525             


Lys Ile Arg Glu Asn Leu Arg Glu Leu Met Asp Lys Glu Pro Thr Val 
    530                 535                 540                 


Val Glu Val Leu Lys Tyr Arg Leu Trp Glu Gln Gln Arg Gly Glu Cys 
545                 550                 555                 560 


Ala Tyr Thr Gln Ser Gln Ile Pro Leu Glu Arg Leu Phe Ser Pro Gly 
                565                 570                 575     


Tyr Cys Glu Ile Asp His Ile Ile Pro Phe Ser Arg Ser Phe Asp Asp 
            580                 585                 590         


Ser Leu Ser Asn Lys Ile Leu Val Leu Gly Ser Glu Asn Gln Arg Lys 
        595                 600                 605             


Gly Asn Arg Thr Pro Tyr Glu Tyr Phe Gly Glu Asp Ser Glu Arg Trp 
    610                 615                 620                 


Asn Ser Phe Glu Ile Trp Val Lys Gly Ser Tyr Leu Asn Tyr Lys Lys 
625                 630                 635                 640 


Lys Ala Asn Leu Leu Lys Lys Lys Phe Ser Glu Glu Glu Gln Arg Asp 
                645                 650                 655     


Trp Lys Ala Arg Asn Leu Gln Asp Thr Lys Tyr Ile Cys Arg Tyr Ile 
            660                 665                 670         


Ser Asn Phe Val Asn Asn Arg Leu Glu Phe Lys Glu Ser Glu Asn Lys 
        675                 680                 685             


Gln Lys Val Ile Thr Val Asn Gly Arg Ala Thr Ala Tyr Leu Arg Ser 
    690                 695                 700                 


Arg Trp Gly Leu Asn Lys Val Arg Glu Asp Gly Asp Lys His His Ala 
705                 710                 715                 720 


Leu Asp Ala Ala Val Val Gly Val Thr Thr Gln Gly Met Val Gln Lys 
                725                 730                 735     


Ile Ser Lys Tyr Ser Lys Ala His Glu Leu Tyr Thr Val Arg Lys Asn 
            740                 745                 750         


Asp Glu Phe Val Asp Val Glu Thr Gly Glu Cys Val Asp Val Asp Glu 
        755                 760                 765             


Tyr Lys Glu Ile Arg Lys Asp Ile Leu Pro Arg Pro Trp Arg Gly Phe 
    770                 775                 780                 


Ser Glu Glu Leu Lys Leu Arg Leu Ser Asp Asn Pro Leu Glu Glu Leu 
785                 790                 795                 800 


Lys Lys Ser Pro Ile Glu Thr Tyr Asn Glu Glu Phe Ile Lys Glu Asn 
                805                 810                 815     


Val Lys Pro Ile Phe Val Ser Arg Val Pro Phe Arg Lys Ile Ser Gly 
            820                 825                 830         


Lys Leu Phe Lys Glu Thr Ile Tyr Ser Glu Arg Ala Phe Lys Asp Gly 
        835                 840                 845             


Tyr Phe Val Ser Lys Lys Ser Leu Val Asp Leu Lys Arg Gly Asp Leu 
    850                 855                 860                 


Asp Asn Phe Tyr Asn Tyr Glu Cys Asp Lys Lys Leu Tyr Asp Ala Ile 
865                 870                 875                 880 


Ser Glu Arg Met Lys Glu Phe Asn Tyr Asn Gly Lys Lys Ala Phe Glu 
                885                 890                 895     


Ser Pro Phe Arg Lys Pro Thr Lys Ser Gly Lys Glu Gly Pro Val Val 
            900                 905                 910         


Arg Ser Val Lys Ile Lys Ser Ala Val Pro Phe Lys Asp Gly Ile Pro 
        915                 920                 925             


Met Asn Glu Gly Leu Val Ala Lys Glu Gly Met Val Arg Ile Asp Ile 
    930                 935                 940                 


Tyr Glu Lys Glu Gly Lys Tyr Phe Val Val Pro Val Tyr Arg Tyr Gln 
945                 950                 955                 960 


Leu Ala Lys Gly Ile Val Pro Lys Arg Ala Ala Ile Ala Lys Lys Asp 
                965                 970                 975     


Glu Leu Lys Trp Pro Ile Met Asp Gln Thr Tyr Asn Phe Lys Phe Ser 
            980                 985                 990         


Ile Tyr Lys Asn Asp Leu Ile Glu  Val Lys Tyr Asp Lys  Lys Gly Val 
        995                 1000                 1005             


Tyr Phe  Gly Tyr Tyr Asp Gly  Phe Asp Arg Asn Ser  Ala Ser Leu 
    1010                 1015                 1020             


Thr Ile  Glu Lys His Asp Asn  Ser Glu Arg Tyr Arg  Ser Ile Gly 
    1025                 1030                 1035             


Leu Lys  Val Gly Val Leu Glu  Ile Asn Lys Tyr Glu  Val Asp Val 
    1040                 1045                 1050             


Leu Gly  Asn Tyr His Lys Val  Lys Leu Gly Gly Asn  
    1055                 1060                 1065 


<210> 167
<211> 1116
<212> PRT
<213> Clostridium spiroforme


<220>
<223> Clostridium spiroforme DSM 1552

<400> 167
Met Val Glu Phe Leu Leu Lys Glu Met Lys Ile Met Gly Arg Leu Val 
1               5                   10                  15      


Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly Tyr Gly Val Ile Asp 
            20                  25                  30          


Ile Asp Lys Asn Glu Phe Val Asp Tyr Gly Val Arg Leu Phe Lys Glu 
        35                  40                  45              


Gly Thr Ala Ile Asn Asn Glu Glu Arg Arg Ser Lys Arg Gly Ala Arg 
    50                  55                  60                  


Arg Leu Lys Arg Arg Lys Thr Asn Arg Ile Ala Asp Met Lys Lys Leu 
65                  70                  75                  80  


Leu Glu Arg Asn Gly Leu Ile Asp Glu Gln Tyr Thr Ala Leu Asn Asn 
                85                  90                  95      


Pro Tyr Glu Ile Arg Lys Lys Gly Leu Lys Asn Lys Leu Ser Asn Tyr 
            100                 105                 110         


Glu Leu Ala Thr Ala Ile Leu His Ile Thr Lys Asn Arg Gly Thr Cys 
        115                 120                 125             


Leu Glu Ser Asn Ala Asp Glu Thr Gln Asp Glu Glu Ser Thr Lys Asn 
    130                 135                 140                 


Ile Leu Ser Lys Asn Ala Leu Glu Leu Lys Asp Lys Tyr Ile Cys Glu 
145                 150                 155                 160 


Ile Gln Leu Ala Arg Leu Glu Glu Ser Gly Lys Ile Arg Gly Ile Asn 
                165                 170                 175     


Asn Asn Phe Lys Thr Glu Asp Tyr Leu Lys Glu Leu Ser Lys Ile Leu 
            180                 185                 190         


Glu Asn Gln Asp Leu Glu Lys Glu Thr Ile Asp Lys Ile Lys Glu Ile 
        195                 200                 205             


Val Ala Arg Arg Arg Arg Tyr Asp Gln Gly Pro Gly Ser Glu Lys Ser 
    210                 215                 220                 


Pro Thr Pro Tyr Gly Ser Tyr Arg Met Glu Asn Gly Glu Leu Val His 
225                 230                 235                 240 


Val Asn Leu Ile Asp Met Met Arg Gly Lys Cys Ser Val Phe Pro Asp 
                245                 250                 255     


Gln Leu Arg Ala Pro Gln Gln Ser Tyr Ser Ala Glu Leu Phe Asn Leu 
            260                 265                 270         


Leu Asn Asp Leu Asn Asn Leu Lys Ile Asn Gly Glu Lys Leu Ser Ser 
        275                 280                 285             


Thr Glu Lys Gln Lys Ile Ile Asp Phe Val Asn Glu Lys Gly Gly Ile 
    290                 295                 300                 


Thr Val Lys Gln Leu Leu Lys Leu Ile Asp Val Gly Ile Thr Glu Ile 
305                 310                 315                 320 


Ser Gly Phe Arg Ile Asp Lys Asn Glu Lys Pro Leu Ile Thr Glu Phe 
                325                 330                 335     


Lys Gly Tyr Lys Lys Val Leu Lys Val Phe Lys Asn Tyr Asn Gln Glu 
            340                 345                 350         


Ser Leu Leu Asn Asp Lys Ser Ile Val Asp Thr Ile Met Asp Ile Asn 
        355                 360                 365             


Thr Lys Ile Lys Ser Ile Asp Glu Arg Ser Asp Gln Leu Lys Gln Val 
    370                 375                 380                 


Leu Pro Ser Leu Asp Thr Ser Ile Ile Asn Asp Leu Ala Ser Ile Lys 
385                 390                 395                 400 


Gly Val Ser Gly Tyr His Ser Leu Ser Leu Lys Ala Leu Asn Leu Ile 
                405                 410                 415     


Asn Asn Glu Met Leu Lys Thr Glu Met Asn Gln Met Gln Val Leu His 
            420                 425                 430         


Gln Leu Asp Ile Phe Asp Lys Asn Arg Val Ser Leu Lys Gly Gln Arg 
        435                 440                 445             


Gln Ile Tyr Ala Asp Asp Asn Ala Ile Leu Ser Pro Val Ala Lys Arg 
    450                 455                 460                 


Ala His Arg Glu Thr Phe Lys Val Ile Asn Lys Leu Arg Ser Ile Tyr 
465                 470                 475                 480 


Gly Glu Phe Asp Ser Ile Val Ile Glu Thr Thr Arg Asp Lys Asn Thr 
                485                 490                 495     


Gln Asp Gln Lys Lys Arg Ile Lys Asn Asn Gln Lys Asn Tyr Glu Glu 
            500                 505                 510         


Arg Asn Thr Glu Val Asn Asn Phe Leu Lys Glu Ala Gly Tyr Asn Pro 
        515                 520                 525             


Glu Asn Ile Asn Ala Lys Thr Lys Met Lys Ile Arg Leu Tyr Ile Glu 
    530                 535                 540                 


Gln Asp Ala Lys Ser Ala Tyr Thr Leu Gln Asp Ile Asn Leu Lys Glu 
545                 550                 555                 560 


Leu Ile Glu Asp Glu Lys Ala Tyr Glu Ile Asp His Ile Ile Pro Ile 
                565                 570                 575     


Ser Ile Ser Leu Asp Asp Ser Phe Asn Asn Lys Val Leu Thr Thr His 
            580                 585                 590         


Asp Glu Asn Gln Glu Lys Gly Asn Leu Thr Pro Ile Ser Ala Phe Leu 
        595                 600                 605             


Lys Gly Lys Phe His Asn Gly Asn Leu Asn Thr Tyr Lys Val Phe Ile 
    610                 615                 620                 


Gln Asn Asn Lys Asn Leu Asn Arg Lys Lys Lys Glu Tyr Leu Leu Cys 
625                 630                 635                 640 


Glu Asp Asp Ile Thr Arg Tyr Glu Val Val Gln Asn Phe Ile Asn Arg 
                645                 650                 655     


Asn Leu Val Asp Thr Ser Tyr Ala Cys Arg Thr Val Met Asn Thr Leu 
            660                 665                 670         


Val His Tyr Phe Lys Asp Asn Glu Ile Asn Thr Lys Val His Thr Ile 
        675                 680                 685             


Lys Gly Gln Ala Thr Ser Thr Phe Arg Lys Arg Ile Gly Leu Ile Lys 
    690                 695                 700                 


Asp Arg Glu Glu Asp Tyr Phe His His Ala Ile Asp Ala Leu Ile Val 
705                 710                 715                 720 


Ala Ser Leu Lys Lys Met Asn Leu Ile Asn Ser Tyr Leu Met Lys Val 
                725                 730                 735     


Asp Phe Asn Glu Met Tyr Asp Glu Glu Thr Gly Glu Ile Phe Asn Val 
            740                 745                 750         


Leu Pro Asp Asn Ser Tyr Leu Asp Glu Lys Tyr Ile Ser Phe Val Ser 
        755                 760                 765             


Asn Leu Lys Asn Ile Tyr Glu Glu Ser Asn Lys Tyr Ile Arg Gly Val 
    770                 775                 780                 


Met Ile Lys Glu Lys Met Thr Tyr Pro Leu Ile Lys Val Ser His Lys 
785                 790                 795                 800 


Ile Asp Thr Lys Pro Asn Arg Lys Ile Ser Asp Asp Thr Ile Tyr Ser 
                805                 810                 815     


Thr Arg Asn Val Asp Asn Gln Asp Met Leu Val Glu Arg Ile Lys Asn 
            820                 825                 830         


Ile Tyr Asp Pro Lys Glu Asn Ala Ala Asn Thr Leu Ile Asn Asp Ile 
        835                 840                 845             


Ile Asn Asp Asn Thr Asp Lys Tyr Ile Met Tyr His Lys Asp Pro Gln 
    850                 855                 860                 


Thr Phe Asp Lys Ile Lys Ala Ile Val Leu Asn His Phe Asn Glu Phe 
865                 870                 875                 880 


Lys Thr Asp Lys Asn Cys Tyr Ile Val Thr Lys Glu Gly Leu Tyr Lys 
                885                 890                 895     


Leu Lys Gly Thr Ser Pro Leu Ala Leu Tyr Tyr Glu Glu Phe Gly Pro 
            900                 905                 910         


Ile Thr Lys Tyr Ala Lys Lys Asn Asn Gly Pro Thr Ile His Ser Met 
        915                 920                 925             


Lys Phe Tyr Ser Glu Lys Leu Gly Asn His Leu Ser Ile Thr His Lys 
    930                 935                 940                 


Tyr Ser Thr Val Asn Lys Lys Val Ile Thr Lys Gln Ile Ser Pro Tyr 
945                 950                 955                 960 


Arg Thr Asp Phe Tyr Gln Ser Pro Glu Gly Lys Tyr Lys Phe Val Thr 
                965                 970                 975     


Val Arg Tyr Lys Asp Val Ala Tyr Asn Ala Lys Lys Asp Lys Tyr Ile 
            980                 985                 990         


Ile Asp His Ser Trp Tyr Arg Glu  Gln Lys Lys Leu Lys  Lys Ile Ala 
        995                 1000                 1005             


Asp Glu  Trp Ile Phe Val Cys  Ser Val His Arg Asp  Glu Leu Ile 
    1010                 1015                 1020             


Gly Ile  Met Lys Ala Asp Gly  Gln Lys Arg Ile Phe  Asp Ser Ser 
    1025                 1030                 1035             


Thr Glu  Ser Asp Gly Glu Thr  Leu Tyr His Asp Ala  Lys Thr Tyr 
    1040                 1045                 1050             


Glu Ile  Leu Lys Phe Thr Ala  Thr Asn Asn Asp Ile  Thr Gly Arg 
    1055                 1060                 1065             


Phe Glu  Val Lys Pro Ile Tyr  Cys Tyr Cys Lys Lys  Gln Leu Met 
    1070                 1075                 1080             


Val Ser  Ile Gly Thr Cys Arg  Lys Ile Gln Lys Phe  Ala Thr Asp 
    1085                 1090                 1095             


Val Leu  Gly Asn Leu Tyr Ile  Val Lys Asp Asn Val  Leu Lys Leu 
    1100                 1105                 1110             


Glu Phe  Lys 
    1115     


<210> 168
<211> 1338
<212> PRT
<213> Coprococcus catus


<220>
<223> Coprococcus catus GD/7

<400> 168
Met Lys Gln Glu Tyr Phe Leu Gly Leu Asp Met Gly Thr Gly Ser Leu 
1               5                   10                  15      


Gly Trp Ala Val Thr Asp Ser Thr Tyr Gln Val Met Arg Lys His Gly 
            20                  25                  30          


Lys Ala Leu Trp Gly Thr Arg Leu Phe Glu Ser Ala Ser Thr Ala Glu 
        35                  40                  45              


Glu Arg Arg Met Phe Arg Thr Ala Arg Arg Arg Leu Asp Arg Arg Asn 
    50                  55                  60                  


Trp Arg Ile Gln Val Leu Gln Glu Ile Phe Ser Glu Glu Ile Ser Lys 
65                  70                  75                  80  


Val Asp Pro Gly Phe Phe Leu Arg Met Lys Glu Ser Lys Tyr Tyr Pro 
                85                  90                  95      


Glu Asp Lys Arg Asp Ala Glu Gly Asn Cys Pro Glu Leu Pro Tyr Ala 
            100                 105                 110         


Leu Phe Val Asp Asp Asn Tyr Thr Asp Lys Asn Tyr His Lys Asp Tyr 
        115                 120                 125             


Pro Thr Ile Tyr His Leu Arg Lys Met Leu Met Glu Thr Thr Glu Ile 
    130                 135                 140                 


Pro Asp Ile Arg Leu Val Tyr Leu Val Leu His His Met Met Lys His 
145                 150                 155                 160 


Arg Gly His Phe Leu Leu Ser Gly Asp Ile Ser Gln Ile Lys Glu Phe 
                165                 170                 175     


Lys Ser Thr Phe Glu Gln Leu Ile Gln Asn Ile Gln Asp Glu Glu Leu 
            180                 185                 190         


Glu Trp His Ile Ser Leu Asp Asp Ala Ala Ile Gln Phe Val Glu His 
        195                 200                 205             


Val Leu Lys Asp Arg Asn Leu Thr Arg Ser Thr Lys Lys Ser Arg Leu 
    210                 215                 220                 


Ile Lys Gln Leu Asn Ala Lys Ser Ala Cys Glu Lys Ala Ile Leu Asn 
225                 230                 235                 240 


Leu Leu Ser Gly Gly Thr Val Lys Leu Ser Asp Ile Phe Asn Asn Lys 
                245                 250                 255     


Glu Leu Asp Glu Ser Glu Arg Pro Lys Val Ser Phe Ala Asp Ser Gly 
            260                 265                 270         


Tyr Asp Asp Tyr Ile Gly Ile Val Glu Ala Glu Leu Ala Glu Gln Tyr 
        275                 280                 285             


Tyr Ile Ile Ala Ser Ala Lys Ala Val Tyr Asp Trp Ser Val Leu Val 
    290                 295                 300                 


Glu Ile Leu Gly Asn Ser Val Ser Ile Ser Glu Ala Lys Ile Lys Val 
305                 310                 315                 320 


Tyr Gln Lys His Gln Ala Asp Leu Lys Thr Leu Lys Lys Ile Val Arg 
                325                 330                 335     


Gln Tyr Met Thr Lys Glu Asp Tyr Lys Arg Val Phe Val Asp Thr Glu 
            340                 345                 350         


Glu Lys Leu Asn Asn Tyr Ser Ala Tyr Ile Gly Met Thr Lys Lys Asn 
        355                 360                 365             


Gly Lys Lys Val Asp Leu Lys Ser Lys Gln Cys Thr Gln Ala Asp Phe 
    370                 375                 380                 


Tyr Asp Phe Leu Lys Lys Asn Val Ile Lys Val Ile Asp His Lys Glu 
385                 390                 395                 400 


Ile Thr Gln Glu Ile Glu Ser Glu Ile Glu Lys Glu Asn Phe Leu Pro 
                405                 410                 415     


Lys Gln Val Thr Lys Asp Asn Gly Val Ile Pro Tyr Gln Val His Asp 
            420                 425                 430         


Tyr Glu Leu Lys Lys Ile Leu Asp Asn Leu Gly Thr Arg Met Pro Phe 
        435                 440                 445             


Ile Lys Glu Asn Ala Glu Lys Ile Gln Gln Leu Phe Glu Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Asn Arg Val Asp Asp Gly Lys Asp Gly 
465                 470                 475                 480 


Lys Phe Thr Trp Ser Val Arg Lys Ser Asp Ala Arg Ile Tyr Pro Trp 
                485                 490                 495     


Asn Phe Thr Glu Val Ile Asp Val Glu Ala Ser Ala Glu Lys Phe Ile 
            500                 505                 510         


Arg Arg Met Thr Asn Lys Cys Thr Tyr Leu Val Gly Glu Asp Val Leu 
        515                 520                 525             


Pro Lys Asp Ser Leu Val Tyr Ser Lys Phe Met Val Leu Asn Glu Leu 
    530                 535                 540                 


Asn Asn Leu Arg Leu Asn Gly Glu Lys Ile Ser Val Glu Leu Lys Gln 
545                 550                 555                 560 


Arg Ile Tyr Glu Glu Leu Phe Cys Lys Tyr Arg Lys Val Thr Arg Lys 
                565                 570                 575     


Lys Leu Glu Arg Tyr Leu Val Ile Glu Gly Ile Ala Lys Lys Gly Val 
            580                 585                 590         


Glu Ile Thr Gly Ile Asp Gly Asp Phe Lys Ala Ser Leu Thr Ala Tyr 
        595                 600                 605             


His Asp Phe Lys Glu Arg Leu Thr Asp Val Gln Leu Ser Gln Arg Ala 
    610                 615                 620                 


Lys Glu Ala Ile Val Leu Asn Val Val Leu Phe Gly Asp Asp Lys Lys 
625                 630                 635                 640 


Leu Leu Lys Gln Arg Leu Ser Lys Met Tyr Pro Asn Leu Thr Thr Gly 
                645                 650                 655     


Gln Leu Lys Gly Ile Cys Ser Leu Ser Tyr Gln Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Lys Thr Phe Leu Glu Glu Ile Thr Val Pro Ala Pro Gly Thr Gly 
        675                 680                 685             


Glu Val Trp Asn Ile Met Thr Ala Leu Trp Gln Thr Asn Asp Asn Leu 
    690                 695                 700                 


Met Gln Leu Leu Ser Arg Asn Tyr Gly Phe Thr Asn Glu Val Glu Glu 
705                 710                 715                 720 


Phe Asn Thr Leu Lys Lys Glu Thr Asp Leu Ser Tyr Lys Thr Val Asp 
                725                 730                 735     


Glu Leu Tyr Val Ser Pro Ala Val Lys Arg Gln Ile Trp Gln Thr Leu 
            740                 745                 750         


Lys Val Val Lys Glu Ile Gln Lys Val Met Gly Asn Ala Pro Lys Arg 
        755                 760                 765             


Val Phe Val Glu Met Ala Arg Glu Lys Gln Glu Gly Lys Arg Ser Asp 
    770                 775                 780                 


Ser Arg Lys Lys Gln Leu Val Glu Leu Tyr Arg Ala Cys Lys Asn Glu 
785                 790                 795                 800 


Glu Arg Asp Trp Ile Thr Glu Leu Asn Ala Gln Ser Asp Gln Gln Leu 
                805                 810                 815     


Arg Ser Asp Lys Leu Phe Leu Tyr Tyr Ile Gln Lys Gly Arg Cys Met 
            820                 825                 830         


Tyr Ser Gly Glu Thr Ile Gln Leu Asp Glu Leu Trp Asp Asn Thr Lys 
        835                 840                 845             


Tyr Asp Ile Asp His Ile Tyr Pro Gln Ser Lys Thr Met Asp Asp Ser 
    850                 855                 860                 


Leu Asn Asn Arg Val Leu Val Lys Lys Asn Tyr Asn Ala Ile Lys Ser 
865                 870                 875                 880 


Asp Thr Tyr Pro Leu Ser Leu Asp Ile Gln Lys Lys Met Met Ser Phe 
                885                 890                 895     


Trp Lys Met Leu Gln Gln Gln Gly Phe Ile Thr Lys Glu Lys Tyr Val 
            900                 905                 910         


Arg Leu Val Arg Ser Asp Glu Leu Ser Ala Asp Glu Leu Ala Gly Phe 
        915                 920                 925             


Ile Glu Arg Gln Ile Val Glu Thr Arg Gln Ser Thr Lys Ala Val Ala 
    930                 935                 940                 


Thr Ile Leu Lys Glu Ala Leu Pro Asp Thr Glu Ile Val Tyr Val Lys 
945                 950                 955                 960 


Ala Gly Asn Val Ser Asn Phe Arg Gln Thr Tyr Glu Leu Leu Lys Val 
                965                 970                 975     


Arg Glu Met Asn Asp Leu His His Ala Lys Asp Ala Tyr Leu Asn Ile 
            980                 985                 990         


Val Val Gly Asn Ala Tyr Phe Val  Lys Phe Thr Lys Asn  Ala Ala Trp 
        995                 1000                 1005             


Phe Ile  Arg Asn Asn Pro Gly  Arg Ser Tyr Asn Leu  Lys Arg Met 
    1010                 1015                 1020             


Phe Glu  Phe Asp Ile Glu Arg  Ser Gly Glu Ile Ala  Trp Lys Ala 
    1025                 1030                 1035             


Gly Asn  Lys Gly Ser Ile Val  Thr Val Lys Lys Val  Met Gln Lys 
    1040                 1045                 1050             


Asn Asn  Ile Leu Val Thr Arg  Lys Ala Tyr Glu Val  Lys Gly Gly 
    1055                 1060                 1065             


Leu Phe  Asp Gln Gln Ile Met  Lys Lys Gly Lys Gly  Gln Val Pro 
    1070                 1075                 1080             


Ile Lys  Gly Asn Asp Glu Arg  Leu Ala Asp Ile Glu  Lys Tyr Gly 
    1085                 1090                 1095             


Gly Tyr  Asn Lys Ala Ala Gly  Thr Tyr Phe Met Leu  Val Lys Ser 
    1100                 1105                 1110             


Leu Asp  Lys Lys Gly Lys Glu  Ile Arg Thr Ile Glu  Phe Val Pro 
    1115                 1120                 1125             


Leu Tyr  Leu Lys Asn Gln Ile  Glu Ile Asn His Glu  Ser Ala Ile 
    1130                 1135                 1140             


Gln Tyr  Leu Ala Gln Glu Arg  Gly Leu Asn Ser Pro  Glu Ile Leu 
    1145                 1150                 1155             


Leu Ser  Lys Ile Lys Ile Asp  Thr Leu Phe Lys Val  Asp Gly Phe 
    1160                 1165                 1170             


Lys Met  Trp Leu Ser Gly Arg  Thr Gly Asn Gln Leu  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ala  Asn Gln Leu Ile Leu  Ser His Gln Glu Ala  Ala Ile Leu 
    1190                 1195                 1200             


Lys Gly  Val Val Lys Tyr Val  Asn Arg Lys Asn Glu  Asn Lys Asp 
    1205                 1210                 1215             


Ala Lys  Leu Ser Glu Arg Asp  Gly Met Thr Glu Glu  Lys Leu Leu 
    1220                 1225                 1230             


Gln Leu  Tyr Asp Thr Phe Leu  Asp Lys Leu Ser Asn  Thr Val Tyr 
    1235                 1240                 1245             


Ser Ile  Arg Leu Ser Ala Gln  Ile Lys Thr Leu Thr  Glu Lys Arg 
    1250                 1255                 1260             


Ala Lys  Phe Ile Gly Leu Ser  Asn Glu Asp Gln Cys  Ile Val Leu 
    1265                 1270                 1275             


Asn Glu  Ile Leu His Met Phe  Gln Cys Gln Ser Gly  Ser Ala Asn 
    1280                 1285                 1290             


Leu Lys  Leu Ile Gly Gly Pro  Gly Ser Ala Gly Ile  Leu Val Met 
    1295                 1300                 1305             


Asn Asn  Asn Ile Thr Ala Cys  Lys Gln Ile Ser Val  Ile Asn Gln 
    1310                 1315                 1320             


Ser Pro  Thr Gly Ile Tyr Glu  Lys Glu Ile Asp Leu  Ile Lys Leu 
    1325                 1330                 1335             


<210> 169
<211> 1384
<212> PRT
<213> Coriobacterium glomerans

<400> 169
Met Lys Leu Arg Gly Ile Glu Asp Asp Tyr Ser Ile Gly Leu Asp Met 
1               5                   10                  15      


Gly Thr Ser Ser Val Gly Trp Ala Val Thr Asp Glu Arg Gly Thr Leu 
            20                  25                  30          


Ala His Phe Lys Arg Lys Pro Thr Trp Gly Ser Arg Leu Phe Arg Glu 
        35                  40                  45              


Ala Gln Thr Ala Ala Val Ala Arg Met Pro Arg Gly Gln Arg Arg Arg 
    50                  55                  60                  


Tyr Val Arg Arg Arg Trp Arg Leu Asp Leu Leu Gln Lys Leu Phe Glu 
65                  70                  75                  80  


Gln Gln Met Glu Gln Ala Asp Pro Asp Phe Phe Ile Arg Leu Arg Gln 
                85                  90                  95      


Ser Arg Leu Leu Arg Asp Asp Arg Ala Glu Glu His Ala Asp Tyr Arg 
            100                 105                 110         


Trp Pro Leu Phe Asn Asp Cys Lys Phe Thr Glu Arg Asp Tyr Tyr Gln 
        115                 120                 125             


Arg Phe Pro Thr Ile Tyr His Val Arg Ser Trp Leu Met Glu Thr Asp 
    130                 135                 140                 


Glu Gln Ala Asp Ile Arg Leu Ile Tyr Leu Ala Leu His Asn Ile Val 
145                 150                 155                 160 


Lys His Arg Gly Asn Phe Leu Arg Glu Gly Gln Ser Leu Ser Ala Lys 
                165                 170                 175     


Ser Ala Arg Pro Asp Glu Ala Leu Asn His Leu Arg Glu Thr Leu Arg 
            180                 185                 190         


Val Trp Ser Ser Glu Arg Gly Phe Glu Cys Ser Ile Ala Asp Asn Gly 
        195                 200                 205             


Ser Ile Leu Ala Met Leu Thr His Pro Asp Leu Ser Pro Ser Asp Arg 
    210                 215                 220                 


Arg Lys Lys Ile Ala Pro Leu Phe Asp Val Lys Ser Asp Asp Ala Ala 
225                 230                 235                 240 


Ala Asp Lys Lys Leu Gly Ile Ala Leu Ala Gly Ala Val Ile Gly Leu 
                245                 250                 255     


Lys Thr Glu Phe Lys Asn Ile Phe Gly Asp Phe Pro Cys Glu Asp Ser 
            260                 265                 270         


Ser Ile Tyr Leu Ser Asn Asp Glu Ala Val Asp Ala Val Arg Ser Ala 
        275                 280                 285             


Cys Pro Asp Asp Cys Ala Glu Leu Phe Asp Arg Leu Cys Glu Val Tyr 
    290                 295                 300                 


Ser Ala Tyr Val Leu Gln Gly Leu Leu Ser Tyr Ala Pro Gly Gln Thr 
305                 310                 315                 320 


Ile Ser Ala Asn Met Val Glu Lys Tyr Arg Arg Tyr Gly Glu Asp Leu 
                325                 330                 335     


Ala Leu Leu Lys Lys Leu Val Lys Ile Tyr Ala Pro Asp Gln Tyr Arg 
            340                 345                 350         


Met Phe Phe Ser Gly Ala Thr Tyr Pro Gly Thr Gly Ile Tyr Asp Ala 
        355                 360                 365             


Ala Gln Ala Arg Gly Tyr Thr Lys Tyr Asn Leu Gly Pro Lys Lys Ser 
    370                 375                 380                 


Glu Tyr Lys Pro Ser Glu Ser Met Gln Tyr Asp Asp Phe Arg Lys Ala 
385                 390                 395                 400 


Val Glu Lys Leu Phe Ala Lys Thr Asp Ala Arg Ala Asp Glu Arg Tyr 
                405                 410                 415     


Arg Met Met Met Asp Arg Phe Asp Lys Gln Gln Phe Leu Arg Arg Leu 
            420                 425                 430         


Lys Thr Ser Asp Asn Gly Ser Ile Tyr His Gln Leu His Leu Glu Glu 
        435                 440                 445             


Leu Lys Ala Ile Val Glu Asn Gln Gly Arg Phe Tyr Pro Phe Leu Lys 
    450                 455                 460                 


Arg Asp Ala Asp Lys Leu Val Ser Leu Val Ser Phe Arg Ile Pro Tyr 
465                 470                 475                 480 


Tyr Val Gly Pro Leu Ser Thr Arg Asn Ala Arg Thr Asp Gln His Gly 
                485                 490                 495     


Glu Asn Arg Phe Ala Trp Ser Glu Arg Lys Pro Gly Met Gln Asp Glu 
            500                 505                 510         


Pro Ile Phe Pro Trp Asn Trp Glu Ser Ile Ile Asp Arg Ser Lys Ser 
        515                 520                 525             


Ala Glu Lys Phe Ile Leu Arg Met Thr Gly Met Cys Thr Tyr Leu Gln 
    530                 535                 540                 


Gln Glu Pro Val Leu Pro Lys Ser Ser Leu Leu Tyr Glu Glu Phe Cys 
545                 550                 555                 560 


Val Leu Asn Glu Leu Asn Gly Ala His Trp Ser Ile Asp Gly Asp Asp 
                565                 570                 575     


Glu His Arg Phe Asp Ala Ala Asp Arg Glu Gly Ile Ile Glu Glu Leu 
            580                 585                 590         


Phe Arg Arg Lys Arg Thr Val Ser Tyr Gly Asp Val Ala Gly Trp Met 
        595                 600                 605             


Glu Arg Glu Arg Asn Gln Ile Gly Ala His Val Cys Gly Gly Gln Gly 
    610                 615                 620                 


Glu Lys Gly Phe Glu Ser Lys Leu Gly Ser Tyr Ile Phe Phe Cys Lys 
625                 630                 635                 640 


Asp Val Phe Lys Val Glu Arg Leu Glu Gln Ser Asp Tyr Pro Met Ile 
                645                 650                 655     


Glu Arg Ile Ile Leu Trp Asn Thr Leu Phe Glu Asp Arg Lys Ile Leu 
            660                 665                 670         


Ser Gln Arg Leu Lys Glu Glu Tyr Gly Ser Arg Leu Ser Ala Glu Gln 
        675                 680                 685             


Ile Lys Thr Ile Cys Lys Lys Arg Phe Thr Gly Trp Gly Arg Leu Ser 
    690                 695                 700                 


Glu Lys Phe Leu Thr Gly Ile Thr Val Gln Val Asp Glu Asp Ser Val 
705                 710                 715                 720 


Ser Ile Met Asp Val Leu Arg Glu Gly Cys Pro Val Ser Gly Lys Arg 
                725                 730                 735     


Gly Arg Ala Met Val Met Met Glu Ile Leu Arg Asp Glu Glu Leu Gly 
            740                 745                 750         


Phe Gln Lys Lys Val Asp Asp Phe Asn Arg Ala Phe Phe Ala Glu Asn 
        755                 760                 765             


Ala Gln Ala Leu Gly Val Asn Glu Leu Pro Gly Ser Pro Ala Val Arg 
    770                 775                 780                 


Arg Ser Leu Asn Gln Ser Ile Arg Ile Val Asp Glu Ile Ala Ser Ile 
785                 790                 795                 800 


Ala Gly Lys Ala Pro Ala Asn Ile Phe Ile Glu Val Thr Arg Asp Glu 
                805                 810                 815     


Asp Pro Lys Lys Lys Gly Arg Arg Thr Lys Arg Arg Tyr Asn Asp Leu 
            820                 825                 830         


Lys Asp Ala Leu Glu Ala Phe Lys Lys Glu Asp Pro Glu Leu Trp Arg 
        835                 840                 845             


Glu Leu Cys Glu Thr Ala Pro Asn Asp Met Asp Glu Arg Leu Ser Leu 
    850                 855                 860                 


Tyr Phe Met Gln Arg Gly Lys Cys Leu Tyr Ser Gly Arg Ala Ile Asp 
865                 870                 875                 880 


Ile His Gln Leu Ser Asn Ala Gly Ile Tyr Glu Val Asp His Ile Ile 
                885                 890                 895     


Pro Arg Thr Tyr Val Lys Asp Asp Ser Leu Glu Asn Lys Ala Leu Val 
            900                 905                 910         


Tyr Arg Glu Glu Asn Gln Arg Lys Thr Asp Met Leu Leu Ile Asp Pro 
        915                 920                 925             


Glu Ile Arg Arg Arg Met Ser Gly Tyr Trp Arg Met Leu His Glu Ala 
    930                 935                 940                 


Lys Leu Ile Gly Asp Lys Lys Phe Arg Asn Leu Leu Arg Ser Arg Ile 
945                 950                 955                 960 


Asp Asp Lys Ala Leu Lys Gly Phe Ile Ala Arg Gln Leu Val Glu Thr 
                965                 970                 975     


Gly Gln Met Val Lys Leu Val Arg Ser Leu Leu Glu Ala Arg Tyr Pro 
            980                 985                 990         


Glu Thr Asn Ile Ile Ser Val Lys  Ala Ser Ile Ser His  Asp Leu Arg 
        995                 1000                 1005             


Thr Ala  Ala Glu Leu Val Lys  Cys Arg Glu Ala Asn  Asp Phe His 
    1010                 1015                 1020             


His Ala  His Asp Ala Phe Leu  Ala Cys Arg Val Gly  Leu Phe Ile 
    1025                 1030                 1035             


Gln Lys  Arg His Pro Cys Val  Tyr Glu Asn Pro Ile  Gly Leu Ser 
    1040                 1045                 1050             


Gln Val  Val Arg Asn Tyr Val  Arg Gln Gln Ala Asp  Ile Phe Lys 
    1055                 1060                 1065             


Arg Cys  Arg Thr Ile Pro Gly  Ser Ser Gly Phe Ile  Val Asn Ser 
    1070                 1075                 1080             


Phe Met  Thr Ser Gly Phe Asp  Lys Glu Thr Gly Glu  Ile Phe Lys 
    1085                 1090                 1095             


Asp Asp  Trp Asp Ala Glu Ala  Glu Val Glu Gly Ile  Arg Arg Ser 
    1100                 1105                 1110             


Leu Asn  Phe Arg Gln Cys Phe  Ile Ser Arg Met Pro  Phe Glu Asp 
    1115                 1120                 1125             


His Gly  Val Phe Trp Asp Ala  Thr Ile Tyr Ser Pro  Arg Ala Lys 
    1130                 1135                 1140             


Lys Thr  Ala Ala Leu Pro Leu  Lys Gln Gly Leu Asn  Pro Ser Arg 
    1145                 1150                 1155             


Tyr Gly  Ser Phe Ser Arg Glu  Gln Phe Ala Tyr Phe  Phe Ile Tyr 
    1160                 1165                 1170             


Lys Ala  Arg Asn Pro Arg Lys  Glu Gln Thr Leu Phe  Glu Phe Ala 
    1175                 1180                 1185             


Gln Val  Pro Val Arg Leu Ser  Ala Gln Ile Arg Gln  Asp Glu Asn 
    1190                 1195                 1200             


Ala Leu  Glu Arg Tyr Ala Arg  Glu Leu Ala Lys Asp  Gln Gly Leu 
    1205                 1210                 1215             


Glu Phe  Ile Arg Ile Glu Arg  Ser Lys Ile Leu Lys  Asn Gln Leu 
    1220                 1225                 1230             


Ile Glu  Ile Asp Gly Asp Arg  Leu Cys Ile Thr Gly  Lys Glu Glu 
    1235                 1240                 1245             


Val Arg  Asn Ala Cys Glu Leu  Ala Phe Ala Gln Asp  Glu Met Arg 
    1250                 1255                 1260             


Val Ile  Arg Met Leu Val Ser  Glu Lys Pro Val Ser  Arg Glu Cys 
    1265                 1270                 1275             


Val Ile  Ser Leu Phe Asn Arg  Ile Leu Leu His Gly  Asp Gln Ala 
    1280                 1285                 1290             


Ser Arg  Arg Leu Ser Lys Gln  Leu Lys Leu Ala Leu  Leu Ser Glu 
    1295                 1300                 1305             


Ala Phe  Ser Glu Ala Ser Asp  Asn Val Gln Arg Asn  Val Val Leu 
    1310                 1315                 1320             


Gly Leu  Ile Ala Ile Phe Asn  Gly Ser Thr Asn Met  Val Asn Leu 
    1325                 1330                 1335             


Ser Asp  Ile Gly Gly Ser Lys  Phe Ala Gly Asn Val  Arg Ile Lys 
    1340                 1345                 1350             


Tyr Lys  Lys Glu Leu Ala Ser  Pro Lys Val Asn Val  His Leu Ile 
    1355                 1360                 1365             


Asp Gln  Ser Val Thr Gly Met  Phe Glu Arg Arg Thr  Lys Ile Gly 
    1370                 1375                 1380             


Leu 
    


<210> 170
<211> 1099
<212> PRT
<213> Corynebacterium accolens


<220>
<223> Corynebacterium accolens ATCC 49725

<400> 170
Met Ser Leu Ser Tyr Arg Val Gly Ile Asp Val Gly Thr Tyr Ser Leu 
1               5                   10                  15      


Gly Cys Thr Ala Ile Glu Val Asp Asp Asn Asp Gln Pro Val Asn Ile 
            20                  25                  30          


Leu Ser Ser Val Ser Leu Ile His Asp Ser Gly Leu Asp Pro Asp Gln 
        35                  40                  45              


Gln Lys Arg Ala Val Thr Arg Leu Ala Ser Ser Gly Val Ala Arg Arg 
    50                  55                  60                  


Thr Arg Arg Leu Tyr Arg Arg Arg Arg Arg Arg Met Ile Asn Leu Glu 
65                  70                  75                  80  


Lys Phe Leu Thr Ser Gln Gly Trp Glu Thr Arg Pro Phe Glu His Tyr 
                85                  90                  95      


Ser Asp Pro Tyr Leu Pro Trp Asn Ala Arg Val Ala Leu Val Asn Gly 
            100                 105                 110         


Tyr Ile Ser Asp Asp Ala Gln Arg Gly Met Tyr Leu Ser Ile Ala Phe 
        115                 120                 125             


Arg His Ile Ala Asn His Arg Gly Trp Arg Asn Pro Tyr Trp Lys Val 
    130                 135                 140                 


Ser Ser Leu Tyr Ser Pro Asp Lys Pro Ser Asp Ala Phe Glu Gln Ile 
145                 150                 155                 160 


Arg Lys Glu Leu Glu Glu Ser Thr Gly His Lys Ile Pro Glu Thr Val 
                165                 170                 175     


Thr Val Gly Gln Leu Ile Ser Phe Ala Gln Phe Gly Lys Asp Arg Leu 
            180                 185                 190         


Arg Gly Gly Gly Lys Lys Lys Asp Glu Lys Lys Pro Gln Glu Gln Val 
        195                 200                 205             


Asn Gln Ala Val Ile Ser Ala Arg Leu His Gln Ile Asp His Ala Arg 
    210                 215                 220                 


Glu Ile Asn Glu Ile Cys Arg Val Gln Lys Ile Asp Asp Ala Leu Arg 
225                 230                 235                 240 


Lys Gln Ile Leu Asp Leu Val Phe Ala Ala Glu Ser Pro Lys Gly Ala 
                245                 250                 255     


Gln Ile Gly Arg Val Gly Lys Asp Pro Leu Gln Pro Lys Leu Pro Arg 
            260                 265                 270         


Ala Leu Lys Ala Ser Asp Ala Phe Gln Gln Tyr Arg Ile Val Ala Leu 
        275                 280                 285             


Ala Gly Asn Leu Arg Ile Tyr Arg Asp Gly Val Ser Thr Pro Leu Asp 
    290                 295                 300                 


Arg Asp Glu Lys Leu Ile Val Phe Asn Tyr Leu Ile Asn Leu Ser His 
305                 310                 315                 320 


Lys Glu Glu Pro Ser Trp Leu Lys Val Ala Glu Val Leu Asn Ile Asp 
                325                 330                 335     


Arg Gly Gln Leu His Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
            340                 345                 350         


Ala Gly Ala Ala Pro Pro Val His Asp Thr Asn Arg Thr Ile Leu Gly 
        355                 360                 365             


Cys Lys Ile Lys Pro Leu Val His Trp Trp Glu Gly Ala Asn Asp Asp 
    370                 375                 380                 


Glu Arg Ala Ala Met Leu Lys Ala Leu Ser Asn Ser Glu Val Glu Asp 
385                 390                 395                 400 


Phe Asp Ser Pro Ala Gly Ala Gln Thr Gln Ala Phe Phe Ala Asn Leu 
                405                 410                 415     


Asp Glu Ser Glu Gln Glu Lys Leu Asp Ser Leu His Leu Pro Ile Gly 
            420                 425                 430         


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Met Arg Leu Thr Ser Arg Met 
        435                 440                 445             


Leu Asp Glu Asn Leu Asp Leu Tyr Glu Ala Arg Leu Ala Glu Phe Asp 
    450                 455                 460                 


Ile Pro Lys Asp Trp Ala Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 
465                 470                 475                 480 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Gly Val Ala Arg Trp Leu 
                485                 490                 495     


Glu Ala Ala Ala Asp Glu Trp Gly Ala Pro Lys Ser Val Val Ile Glu 
            500                 505                 510         


His Val Arg Asp Gly Phe Ile Ser Lys Ser Lys Ala Asn Glu Ile Asp 
        515                 520                 525             


Arg Ala Asn Asn Ala Arg His Lys Arg Asn Arg Glu Leu Phe Lys Gln 
    530                 535                 540                 


Met Gln Glu Asn Leu Gly Ile Asp Gly Lys Leu Arg Ser Ser Asp Leu 
545                 550                 555                 560 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
                565                 570                 575     


Gly Ser Pro Ile Thr Tyr Thr Thr Cys Glu Met Asp His Ile Val Pro 
            580                 585                 590         


Arg Ala Gly Glu Gly Ser Thr Asn Thr Arg Asp Asn Leu Val Ala Thr 
        595                 600                 605             


Cys His Arg Cys Asn Leu Ala Lys Lys Asn Ile Pro Phe Ala Val Trp 
    610                 615                 620                 


Ala Ala Gln Thr Asn Ile Pro Gly Val Ser Val Lys Glu Ala Leu Asp 
625                 630                 635                 640 


Arg Thr Arg His Trp Ser Glu Asp Ser Gly Met Thr Ser Lys Asp Phe 
                645                 650                 655     


Lys Lys Phe Arg Lys Asn Val Cys Asp Arg Leu Lys Arg Thr Val Val 
            660                 665                 670         


Asp Glu Pro Leu Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
        675                 680                 685             


Asn Glu Leu Arg Gly Arg Val Ala Gln Arg Phe Gln Glu Glu Asn Thr 
    690                 695                 700                 


Val Val Asn Val Tyr Arg Gly Glu Leu Thr Ala Glu Ala Arg Arg Ala 
705                 710                 715                 720 


Ala Gly Ile Ser Asp Lys Leu Arg Phe Ile Asp Gly Thr Gly Lys Ser 
                725                 730                 735     


Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ala Val Val Ala Phe 
            740                 745                 750         


Thr Gln Asn Tyr Val Ala Glu Thr Leu Ala Ile Arg Ser Asn Lys Lys 
        755                 760                 765             


Arg Glu Ala Gln Leu Leu Gln Ala Ala Glu Gln Trp Lys Glu Phe Thr 
    770                 775                 780                 


Gly Ser Asp Ala Glu His Arg Ala Ala Trp Asn Ala Trp Leu Pro Lys 
785                 790                 795                 800 


Met Gln Lys Leu Ala Val Leu Leu Gln Lys Ala Leu Asp Glu Asp Arg 
                805                 810                 815     


Ile Ala Val Thr Ser Asn Leu Arg Leu Arg Leu Gly Asn Gly Arg Ala 
            820                 825                 830         


His Glu Asp Ser Ile Gly Glu Leu Lys Thr Ile Arg Val Gly Asp Ala 
        835                 840                 845             


Ile Ser Val Thr Asp Ile Asp Arg Ala Ser Ser Glu Ala Leu Trp Cys 
    850                 855                 860                 


Ala Leu Thr Arg Glu Pro Asp Phe Asp Glu Asn Asn Gly Leu Pro Glu 
865                 870                 875                 880 


Asn Pro Asp Arg Arg Ile Arg Ile His Gly Thr Trp Tyr Asp Ala Glu 
                885                 890                 895     


Asp Asp Ile Glu Val Phe Pro Val Gly Ala Gly Ala Ile Lys Val Arg 
            900                 905                 910         


Gly Gly Tyr Ala Glu Leu Ser Arg Phe His His Ala Arg Ile Tyr Lys 
        915                 920                 925             


Ile Pro Gly Lys Lys Ala Pro Val Tyr Cys Met Leu Arg Val Tyr Asn 
    930                 935                 940                 


Ala Asp Leu Ile Arg His Arg His Glu Asp Leu Phe Ser Val Glu Ile 
945                 950                 955                 960 


Lys Pro Gln Thr Met Ser Val Arg Gln Ala Glu Pro Lys Leu Arg Lys 
                965                 970                 975     


Ala Leu Ala Glu Asn Thr Ala Glu Tyr Leu Gly Trp Leu Val Thr Asp 
            980                 985                 990         


Asp Glu Leu Val Ile Asp Thr Ser  Asn Phe Asn Thr Gly  Gln Ile Ala 
        995                 1000                 1005             


Glu Met  Gln Ser Glu Leu Gly  Gln Val Arg Arg Trp  Arg Leu Asp 
    1010                 1015                 1020             


Gly Phe  Tyr Ser Pro Ser Thr  Leu Arg Leu Arg Pro  Leu Gln Met 
    1025                 1030                 1035             


Ser Ala  Glu Gly Leu Arg Glu  Asp Thr Ser Ile Gly  Ala Lys Lys 
    1040                 1045                 1050             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Ile Asn  Lys Leu Phe 
    1055                 1060                 1065             


Gly Glu  Gly His Val Thr Val  Val Arg Arg Asp Ala  Leu Gly Arg 
    1070                 1075                 1080             


Ala Arg  Leu Thr Ser Asn Ala  His Leu Pro Ile Ser  Trp Lys Ala 
    1085                 1090                 1095             


Glu 
    


<210> 171
<211> 1099
<212> PRT
<213> Corynebacterium accolens


<220>
<223> Corynebacterium accolens ATCC 49726

<400> 171
Met Ser Leu Leu Tyr Arg Val Gly Ile Asp Val Gly Thr Tyr Ser Leu 
1               5                   10                  15      


Gly Cys Thr Ala Ile Glu Val Asp Asp Asn Asp Gln Pro Val Ser Ile 
            20                  25                  30          


Leu Ser Ser Val Ser Leu Ile His Asp Ser Gly Leu Asp Pro Asp Gln 
        35                  40                  45              


Gln Lys Arg Ala Val Thr Arg Leu Ala Ser Ser Gly Val Ala Arg Arg 
    50                  55                  60                  


Thr Arg Arg Leu Tyr Arg Arg Arg Arg Arg Arg Met Val Lys Leu Glu 
65                  70                  75                  80  


Asn Phe Leu Thr Ala Gln Gly Trp Glu Thr Leu Pro Phe Glu Arg Tyr 
                85                  90                  95      


Ser Asp Pro Tyr Leu Pro Trp His Ala Arg Val Ala Leu Val Asn Gly 
            100                 105                 110         


Tyr Ile Ser Asp Asp Thr Gln Arg Gly Gln Tyr Leu Ser Ile Ala Phe 
        115                 120                 125             


Arg His Ile Ala Asn His Arg Gly Trp Arg Asn Pro Tyr Trp Lys Val 
    130                 135                 140                 


Ser Ser Leu Tyr Ser Pro Asp Lys Pro Ser Asp Ala Phe Glu Gln Ile 
145                 150                 155                 160 


Arg Lys Glu Leu Glu Ala Ser Thr Gly Arg Gln Ile Pro Glu Thr Ala 
                165                 170                 175     


Thr Val Gly Gln Leu Ile Ser Phe Ala Gln Phe Gly Lys Asp Arg Leu 
            180                 185                 190         


Arg Gly Gly Gly Lys Gln Lys Asp Lys Lys Lys Pro Gln Glu Gln Val 
        195                 200                 205             


Asn Gln Ala Val Ile Ser Ala Arg Leu His Gln Ile Asp His Ala Arg 
    210                 215                 220                 


Glu Ile Asn Glu Ile Cys Arg Val Gln Lys Ile Asp Asp Thr Leu Arg 
225                 230                 235                 240 


Lys Gln Ile Leu Asp Leu Val Phe Ala Ala Glu Ser Pro Lys Gly Ala 
                245                 250                 255     


Gln Lys Gly Arg Val Gly Lys Asp Pro Leu Gln Pro Lys Leu Phe Arg 
            260                 265                 270         


Ala Leu Lys Ala Ser Asp Ala Phe Gln Gln Tyr Arg Ile Ala Ala Leu 
        275                 280                 285             


Thr Gly Asn Leu Arg Ile Tyr Arg Asn Gly Val Thr Val Pro Leu Asp 
    290                 295                 300                 


Arg Asp Glu Lys Leu Ile Val Phe Asn Tyr Leu Val Asn Leu Pro Lys 
305                 310                 315                 320 


Lys Glu Glu Pro Ser Trp Leu Lys Ile Ala Glu Ile Leu Asn Ile Asp 
                325                 330                 335     


Arg Gly Gln Leu Arg Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
            340                 345                 350         


Ala Gly Ala Thr Pro Pro Val His Asp Thr Asn Arg Thr Ile Leu Asp 
        355                 360                 365             


Ser Lys Val Lys Pro Leu Ala His Trp Trp Glu Asn Ala Ser Asp Asp 
    370                 375                 380                 


Glu Arg Ala Ala Met Leu Lys Ser Leu Ser Asn Ser Glu Val Glu Asp 
385                 390                 395                 400 


Phe Asp Ser Pro Ala Gly Ala Gln Val Gln Ala Phe Phe Ala Asp Leu 
                405                 410                 415     


Asp Glu Thr Glu Gln Glu Lys Leu Asp Ser Leu His Leu Pro Met Gly 
            420                 425                 430         


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Met Arg Leu Thr Asn Arg Met 
        435                 440                 445             


Leu Asp Glu Asn Leu Asp Leu Tyr Glu Ala Arg Leu Ala Glu Phe Gly 
    450                 455                 460                 


Ile Pro Lys Asp Trp Ala Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 
465                 470                 475                 480 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Gly Val Ala Arg Trp Leu 
                485                 490                 495     


Glu Ala Ala Ala Asp Glu Trp Gly Ala Pro Lys Ser Val Val Ile Glu 
            500                 505                 510         


His Val Arg Asp Gly Phe Val Ser Lys Ser Lys Ala Ile Glu Ile Asp 
        515                 520                 525             


Arg Ala Asn Asn Asn Arg His Lys Arg Asn Arg Glu Leu Phe Gln Lys 
    530                 535                 540                 


Met Gln Glu Asn Leu Gly Ile Glu Gly Lys Val Arg Ser Ser Asp Leu 
545                 550                 555                 560 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
                565                 570                 575     


Gly Ser Pro Ile Thr Tyr Thr Thr Cys Glu Met Asp His Ile Val Pro 
            580                 585                 590         


Arg Ala Gly Glu Gly Ser Thr Asn Thr Arg Asp Asn Leu Val Ala Thr 
        595                 600                 605             


Cys His Arg Cys Asn Leu Ala Lys Lys Asn Ile Pro Phe Ala Val Trp 
    610                 615                 620                 


Ala Glu Lys Ser Thr Ile Pro Gly Val Ser Val Lys Glu Ala Leu Asp 
625                 630                 635                 640 


Arg Thr Arg His Trp Ser Glu Asp Ser Gly Met Ser Lys Lys Asp Phe 
                645                 650                 655     


Gln Lys Phe Arg Lys Asn Val Cys Glu Arg Leu Asn Arg Thr Val Val 
            660                 665                 670         


Asp Glu Pro Leu Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
        675                 680                 685             


Asn Glu Leu Arg Gly Arg Val Ala Gln Arg Phe Gln Glu Glu Asn Thr 
    690                 695                 700                 


Thr Val Asn Val Tyr Arg Gly Ala Leu Thr Ala Glu Ala Arg Arg Ala 
705                 710                 715                 720 


Ala Gly Ile Thr Asp Lys Leu Arg Phe Ile Asp Gly Thr Gly Lys Ser 
                725                 730                 735     


Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ala Val Val Ala Phe 
            740                 745                 750         


Ile His Asn Tyr Val Ala Glu Thr Leu Ala Ile Arg Ser Asn Lys Lys 
        755                 760                 765             


Arg Glu Ala Gln Leu Leu Gln Gly Thr Ser Gln Trp Lys Glu Phe Thr 
    770                 775                 780                 


Gly Ser Asp Asp Lys His Arg Ala Val Trp Asn Ala Trp Ile Pro Lys 
785                 790                 795                 800 


Met Gln Lys Leu Ala Val Leu Leu Gln Ile Ala Leu Asp Glu Asp Arg 
                805                 810                 815     


Ile Val Val Thr Ser Asn Leu Arg Leu Arg Leu Gly Asn Gly Arg Ala 
            820                 825                 830         


His Glu Asp Thr Ile Ser Glu Leu Lys Thr Ile Arg Val Gly Asp Ala 
        835                 840                 845             


Ile Ser Val Thr Asp Ile Asp Arg Ala Ser Ser Glu Ala Leu Trp Cys 
    850                 855                 860                 


Ala Leu Thr Arg Glu Pro Asp Phe Asp Glu Lys Asp Gly Leu Pro Glu 
865                 870                 875                 880 


Asn Pro Asn Arg Arg Ile Arg Val His Gly Thr Trp Tyr Asp Ala Glu 
                885                 890                 895     


Asp Glu Ile Glu Val Phe Pro Val Gly Ala Gly Ala Ile Lys Val Arg 
            900                 905                 910         


Gly Gly Tyr Ala Lys Leu Ser Arg Phe His His Ala Arg Val Tyr Lys 
        915                 920                 925             


Ile Pro Gly Lys Lys Ala Pro Ile Tyr Cys Met Leu Arg Val Tyr Asn 
    930                 935                 940                 


Thr Asp Leu Val Gln His Arg His Glu Asp Leu Phe Ser Val Glu Leu 
945                 950                 955                 960 


Lys Pro Gln Thr Met Ser Val Arg Gln Ala Glu Pro Lys Leu Arg Lys 
                965                 970                 975     


Ala Leu Ala Glu Asn Thr Ala Glu Tyr Leu Gly Trp Leu Val Thr Asp 
            980                 985                 990         


Asp Glu Leu Ile Ile Asp Thr Ser  Thr Phe Arg Thr Gly  Leu Ile Glu 
        995                 1000                 1005             


Glu Met  Gln Ser Glu Phe Gly  Leu Val Arg Arg Trp  Arg Leu Asp 
    1010                 1015                 1020             


Gly Phe  Asp Ser Pro Ser Leu  Leu Thr Leu Arg Pro  Leu His Met 
    1025                 1030                 1035             


Ser Ala  Glu Gly Leu Pro Asp  Asp Cys Ala Leu Gly  Ser Arg Lys 
    1040                 1045                 1050             


Ile Ile  Asp Thr Lys Gly Trp  Arg Val Ser Ile Asn  Lys Val Phe 
    1055                 1060                 1065             


Asn Ala  Gly Asn Thr Thr Val  Val Arg Arg Asp Ala  Leu Gly Arg 
    1070                 1075                 1080             


Ala Arg  Leu Thr Ser Asn Ala  His Leu Pro Ile Ser  Trp Lys Glu 
    1085                 1090                 1095             


Glu 
    


<210> 172
<211> 1084
<212> PRT
<213> Corynebacterium diphtheriae

<400> 172
Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 
1               5                   10                  15      


Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 
            20                  25                  30          


Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Lys Ile Lys 
        35                  40                  45              


Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 
    50                  55                  60                  


Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 
65                  70                  75                  80  


Ile Gln Arg Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 
                85                  90                  95      


Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 
            100                 105                 110         


Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 
        115                 120                 125             


Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 
    130                 135                 140                 


Leu Tyr Leu Pro Asp Glu Pro Ser Asp Ala Phe Lys Ala Ile Arg Glu 
145                 150                 155                 160 


Glu Ile Lys Arg Ala Ser Gly Gln Pro Val Pro Glu Thr Ala Thr Val 
                165                 170                 175     


Gly Gln Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 
            180                 185                 190         


Glu Gly Gly Val Leu Ser Ala Arg Leu Gln Gln Ser Asp His Ala Arg 
        195                 200                 205             


Glu Ile Gln Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 
    210                 215                 220                 


Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 
225                 230                 235                 240 


Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn Arg 
                245                 250                 255     


Ala Leu Lys Ala Ser Asp Ala Phe Gln Arg Tyr Arg Ile Ala Ala Leu 
            260                 265                 270         


Ile Gly Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 
        275                 280                 285             


Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Ala Pro 
    290                 295                 300                 


Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 
305                 310                 315                 320 


Arg Gly Gln Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
                325                 330                 335     


Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 
            340                 345                 350         


Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 
        355                 360                 365             


Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 
    370                 375                 380                 


Phe Asp Ser Pro Glu Gly Ala Lys Val Gln Ala Phe Phe Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 
                405                 410                 415     


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 
            420                 425                 430         


Leu Ala Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gln Glu Phe Gly 
        435                 440                 445             


Ile Glu Pro Ser Trp Thr Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 
    450                 455                 460                 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 
465                 470                 475                 480 


Lys Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 
                485                 490                 495     


His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 
            500                 505                 510         


Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln Glu 
        515                 520                 525             


Met Gln Glu Lys Leu Asn Val Gln Gly Lys Pro Ser Arg Ala Asp Leu 
    530                 535                 540                 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
545                 550                 555                 560 


Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 
                565                 570                 575     


Arg Ala Gly Gln Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 
            580                 585                 590         


Cys His Arg Cys Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 
        595                 600                 605             


Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 
    610                 615                 620                 


Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Ala Thr Met 
                645                 650                 655     


Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
            660                 665                 670         


Asn Glu Leu Arg Ser Arg Val Ala Gln His Phe Ala Ser His Gly Thr 
        675                 680                 685             


Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 
    690                 695                 700                 


Ser Gly Ile Ser Gly Lys Leu Glu Phe Leu Asp Gly Val Gly Lys Ser 
705                 710                 715                 720 


Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 
                725                 730                 735     


Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 
            740                 745                 750         


Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr 
        755                 760                 765             


Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gln Lys 
    770                 775                 780                 


Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 
785                 790                 795                 800 


Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 
                805                 810                 815     


His Glu Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gln 
            820                 825                 830         


Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 
        835                 840                 845             


Ala Leu Thr Arg Glu Pro Asp Phe Asp Pro Lys Asp Gly Leu Pro Ala 
    850                 855                 860                 


Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 
865                 870                 875                 880 


Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 
                885                 890                 895     


Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 
            900                 905                 910         


Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 
        915                 920                 925             


Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gln Asp Leu Phe Ser Val Glu 
    930                 935                 940                 


Leu Lys Pro Gln Thr Met Ser Met Arg Gln Ala Glu Lys Lys Leu Arg 
945                 950                 955                 960 


Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 
                965                 970                 975     


Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 
            980                 985                 990         


Lys Ala Val Glu Ala Glu Leu Gly  Thr Ile Arg Arg Trp  Arg Val Asp 
        995                 1000                 1005             


Gly Phe  Phe Gly Asp Thr Arg  Leu Arg Leu Arg Pro  Leu Gln Met 
    1010                 1015                 1020             


Ser Lys  Glu Gly Ile Lys Lys  Glu Ser Ala Pro Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Lys Leu Phe 
    1040                 1045                 1050             


Ser Glu  Gly Asn Val Thr Val  Val Arg Arg Asp Ser  Leu Gly Arg 
    1055                 1060                 1065             


Val Arg  Leu Glu Ser Thr Ala  His Leu Pro Val Thr  Trp Lys Val 
    1070                 1075                 1080             


Gln 
    


<210> 173
<211> 1084
<212> PRT
<213> Corynebacterium diphtheriae

<400> 173
Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 
1               5                   10                  15      


Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 
            20                  25                  30          


Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Lys Met Lys 
        35                  40                  45              


Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 
    50                  55                  60                  


Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 
65                  70                  75                  80  


Ile Gln Arg Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 
                85                  90                  95      


Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 
            100                 105                 110         


Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 
        115                 120                 125             


Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 
    130                 135                 140                 


Leu Tyr Leu Pro Asp Glu Pro Ser Asp Ala Phe Lys Ser Ile Arg Glu 
145                 150                 155                 160 


Glu Ile Lys Arg Ala Ser Gly Gln Pro Val Pro Glu Thr Ala Thr Val 
                165                 170                 175     


Gly Gln Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 
            180                 185                 190         


Glu Gly Gly Val Leu Ser Ala Arg Leu Gln Gln Ser Asp His Ala Arg 
        195                 200                 205             


Glu Ile Gln Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 
    210                 215                 220                 


Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 
225                 230                 235                 240 


Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn Arg 
                245                 250                 255     


Ala Leu Lys Ala Ser Asp Ala Phe Gln Arg Tyr Arg Ile Ala Ala Leu 
            260                 265                 270         


Ile Gly Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 
        275                 280                 285             


Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Ala Pro 
    290                 295                 300                 


Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 
305                 310                 315                 320 


Arg Gly Gln Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
                325                 330                 335     


Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 
            340                 345                 350         


Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 
        355                 360                 365             


Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 
    370                 375                 380                 


Phe Asp Ser Pro Glu Gly Ala Lys Val Gln Ala Phe Phe Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 
                405                 410                 415     


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 
            420                 425                 430         


Leu Ala Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gln Glu Phe Gly 
        435                 440                 445             


Ile Glu Pro Ser Trp Thr Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 
    450                 455                 460                 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 
465                 470                 475                 480 


Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 
                485                 490                 495     


His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 
            500                 505                 510         


Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln Glu 
        515                 520                 525             


Met Gln Glu Lys Leu Asn Val Gln Gly Lys Pro Ser Arg Ala Asp Leu 
    530                 535                 540                 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
545                 550                 555                 560 


Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 
                565                 570                 575     


Arg Ala Gly Gln Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 
            580                 585                 590         


Cys His Arg Cys Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 
        595                 600                 605             


Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 
    610                 615                 620                 


Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Ala Thr Met 
                645                 650                 655     


Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
            660                 665                 670         


Asn Glu Leu Arg Ser Arg Val Ala Gln His Phe Ala Ser His Gly Thr 
        675                 680                 685             


Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 
    690                 695                 700                 


Ser Gly Ile Ser Gly Lys Leu Glu Phe Leu Asp Gly Val Gly Lys Ser 
705                 710                 715                 720 


Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 
                725                 730                 735     


Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 
            740                 745                 750         


Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr 
        755                 760                 765             


Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gln Lys 
    770                 775                 780                 


Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 
785                 790                 795                 800 


Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 
                805                 810                 815     


His Glu Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gln 
            820                 825                 830         


Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 
        835                 840                 845             


Ala Leu Thr Arg Glu Pro Asp Phe Asp Pro Lys Asp Gly Leu Pro Ala 
    850                 855                 860                 


Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 
865                 870                 875                 880 


Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 
                885                 890                 895     


Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 
            900                 905                 910         


Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 
        915                 920                 925             


Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gln Asp Leu Phe Ser Val Glu 
    930                 935                 940                 


Leu Lys Pro Gln Thr Met Ser Met Arg Gln Ala Glu Lys Lys Leu Arg 
945                 950                 955                 960 


Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 
                965                 970                 975     


Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 
            980                 985                 990         


Lys Ala Val Glu Ala Glu Leu Gly  Thr Ile Arg Arg Trp  Arg Val Asp 
        995                 1000                 1005             


Gly Phe  Phe Gly Asp Thr Arg  Leu Arg Leu Arg Pro  Leu Gln Met 
    1010                 1015                 1020             


Ser Lys  Glu Gly Ile Lys Lys  Glu Ser Ala Pro Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Lys Leu Phe 
    1040                 1045                 1050             


Ser Glu  Gly Asn Val Thr Val  Val Arg Arg Asp Ser  Leu Gly Arg 
    1055                 1060                 1065             


Val Arg  Leu Glu Ser Thr Ala  His Leu Pro Val Thr  Trp Lys Val 
    1070                 1075                 1080             


Gln 
    


<210> 174
<211> 1084
<212> PRT
<213> Corynebacterium diphtheriae

<400> 174
Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 
1               5                   10                  15      


Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 
            20                  25                  30          


Leu Val Ser His Ile His Asp Ser Arg Leu Asp Pro Asp Lys Ile Lys 
        35                  40                  45              


Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 
    50                  55                  60                  


Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 
65                  70                  75                  80  


Ile Gln Arg Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 
                85                  90                  95      


Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 
            100                 105                 110         


Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 
        115                 120                 125             


Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 
    130                 135                 140                 


Leu Tyr Leu Pro Asp Glu Pro Ser Asp Ala Phe Lys Ala Ile Arg Glu 
145                 150                 155                 160 


Glu Ile Lys Arg Ala Ser Gly Gln Pro Val Pro Glu Thr Ala Thr Val 
                165                 170                 175     


Gly Gln Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 
            180                 185                 190         


Glu Gly Gly Val Leu Ser Ala Arg Leu Gln Gln Ser Asp His Ala Arg 
        195                 200                 205             


Glu Ile Gln Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 
    210                 215                 220                 


Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 
225                 230                 235                 240 


Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn Arg 
                245                 250                 255     


Ala Leu Lys Ala Ser Asp Ala Phe Gln Arg Tyr Arg Ile Ala Ala Leu 
            260                 265                 270         


Ile Gly Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 
        275                 280                 285             


Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Ala Pro 
    290                 295                 300                 


Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 
305                 310                 315                 320 


Arg Gly Gln Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
                325                 330                 335     


Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 
            340                 345                 350         


Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 
        355                 360                 365             


Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 
    370                 375                 380                 


Phe Asp Ser Pro Glu Gly Ala Lys Val Gln Ala Phe Phe Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 
                405                 410                 415     


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 
            420                 425                 430         


Leu Ala Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gln Glu Phe Gly 
        435                 440                 445             


Ile Glu Pro Ser Trp Thr Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 
    450                 455                 460                 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 
465                 470                 475                 480 


Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 
                485                 490                 495     


His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 
            500                 505                 510         


Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln Glu 
        515                 520                 525             


Met Gln Glu Lys Leu Asn Ile Gln Gly Lys Pro Ser Arg Ala Asp Leu 
    530                 535                 540                 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
545                 550                 555                 560 


Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 
                565                 570                 575     


Arg Ala Gly Gln Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 
            580                 585                 590         


Cys His Arg Cys Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 
        595                 600                 605             


Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 
    610                 615                 620                 


Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Val Thr Met 
                645                 650                 655     


Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
            660                 665                 670         


Asn Glu Leu Arg Ser Arg Val Ala Gln His Phe Ala Ser Arg Gly Thr 
        675                 680                 685             


Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 
    690                 695                 700                 


Ser Gly Ile Ser Gly Lys Leu Glu Phe Leu Asp Gly Val Gly Lys Ser 
705                 710                 715                 720 


Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 
                725                 730                 735     


Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 
            740                 745                 750         


Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr 
        755                 760                 765             


Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gln Lys 
    770                 775                 780                 


Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 
785                 790                 795                 800 


Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 
                805                 810                 815     


His Glu Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gln 
            820                 825                 830         


Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 
        835                 840                 845             


Ala Leu Thr Arg Glu Pro Asp Phe Asp Pro Lys Asp Gly Leu Pro Ala 
    850                 855                 860                 


Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 
865                 870                 875                 880 


Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 
                885                 890                 895     


Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 
            900                 905                 910         


Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 
        915                 920                 925             


Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gln Asp Leu Phe Ser Val Glu 
    930                 935                 940                 


Leu Lys Pro Gln Thr Met Ser Met Arg Gln Ala Glu Lys Lys Leu Arg 
945                 950                 955                 960 


Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 
                965                 970                 975     


Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 
            980                 985                 990         


Lys Ala Val Glu Ala Glu Leu Gly  Thr Ile Arg Arg Trp  Arg Val Asp 
        995                 1000                 1005             


Gly Phe  Phe Gly Asp Thr Arg  Leu Arg Leu Arg Pro  Leu Gln Met 
    1010                 1015                 1020             


Ser Lys  Glu Gly Ile Lys Lys  Glu Ser Ala Pro Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Lys Leu Phe 
    1040                 1045                 1050             


Ser Glu  Gly Asn Val Thr Val  Val Arg Arg Asp Ser  Leu Gly Arg 
    1055                 1060                 1065             


Val Arg  Leu Glu Ser Thr Ala  His Leu Pro Val Thr  Trp Lys Val 
    1070                 1075                 1080             


Gln 
    


<210> 175
<211> 1084
<212> PRT
<213> Corynebacterium diphtheriae


<220>
<223> Corynebacterium diphtheriae bv. intermedius str. NCTC 5011

<400> 175
Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 
1               5                   10                  15      


Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 
            20                  25                  30          


Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Glu Ile Lys 
        35                  40                  45              


Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 
    50                  55                  60                  


Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 
65                  70                  75                  80  


Ile Gln Arg Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 
                85                  90                  95      


Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 
            100                 105                 110         


Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 
        115                 120                 125             


Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 
    130                 135                 140                 


Leu Tyr Leu Pro Asp Gly Pro Ser Asp Ala Phe Lys Ala Ile Arg Glu 
145                 150                 155                 160 


Glu Ile Lys Arg Ala Ser Gly Gln Pro Val Pro Glu Thr Ala Thr Val 
                165                 170                 175     


Gly Gln Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 
            180                 185                 190         


Glu Gly Gly Val Leu Ser Ala Arg Leu Gln Gln Ser Asp His Ala Arg 
        195                 200                 205             


Glu Ile Gln Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 
    210                 215                 220                 


Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 
225                 230                 235                 240 


Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn Arg 
                245                 250                 255     


Ala Leu Lys Ala Ser Asp Ala Phe Gln Arg Tyr Arg Ile Ala Ala Leu 
            260                 265                 270         


Ile Gly Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 
        275                 280                 285             


Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Ala Pro 
    290                 295                 300                 


Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 
305                 310                 315                 320 


Arg Gly Gln Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
                325                 330                 335     


Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 
            340                 345                 350         


Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 
        355                 360                 365             


Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 
    370                 375                 380                 


Phe Asp Ser Pro Glu Gly Ala Lys Val Gln Ala Phe Phe Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 
                405                 410                 415     


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 
            420                 425                 430         


Leu Ala Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gln Glu Phe Gly 
        435                 440                 445             


Ile Glu Pro Ser Trp Thr Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 
    450                 455                 460                 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 
465                 470                 475                 480 


Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 
                485                 490                 495     


His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 
            500                 505                 510         


Gly Asp Met Gln Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln Glu 
        515                 520                 525             


Met Gln Glu Lys Leu Asn Val Gln Gly Lys Pro Ser Arg Ala Asp Leu 
    530                 535                 540                 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
545                 550                 555                 560 


Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 
                565                 570                 575     


Arg Ala Gly Gln Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 
            580                 585                 590         


Cys His Arg Cys Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 
        595                 600                 605             


Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 
    610                 615                 620                 


Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Pro Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Ala Thr Met 
                645                 650                 655     


Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
            660                 665                 670         


Asn Glu Leu Arg Ser Arg Val Ala Gln His Phe Ala Ser His Gly Thr 
        675                 680                 685             


Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 
    690                 695                 700                 


Ser Gly Ile Ser Gly Lys Leu Lys Phe Phe Asp Gly Val Gly Lys Ser 
705                 710                 715                 720 


Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 
                725                 730                 735     


Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 
            740                 745                 750         


Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr 
        755                 760                 765             


Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gln Lys 
    770                 775                 780                 


Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 
785                 790                 795                 800 


Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 
                805                 810                 815     


His Lys Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gln 
            820                 825                 830         


Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 
        835                 840                 845             


Ala Leu Thr Arg Glu Pro Asp Phe Asp Pro Lys Glu Gly Leu Pro Ala 
    850                 855                 860                 


Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 
865                 870                 875                 880 


Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 
                885                 890                 895     


Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 
            900                 905                 910         


Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 
        915                 920                 925             


Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gln Asp Leu Phe Ser Val Glu 
    930                 935                 940                 


Leu Lys Pro Gln Thr Met Ser Met Arg Gln Ala Glu Lys Lys Leu Arg 
945                 950                 955                 960 


Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 
                965                 970                 975     


Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 
            980                 985                 990         


Lys Ala Val Glu Ala Glu Leu Gly  Thr Ile Arg Arg Trp  Arg Val Asp 
        995                 1000                 1005             


Gly Phe  Phe Ser Pro Ser Lys  Leu Arg Leu Arg Pro  Leu Gln Met 
    1010                 1015                 1020             


Ser Lys  Glu Gly Ile Lys Lys  Glu Ser Ala Pro Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Lys Leu Phe 
    1040                 1045                 1050             


Ser Asp  Gly Asn Val Thr Val  Val Arg Arg Asp Ser  Leu Gly Arg 
    1055                 1060                 1065             


Val Arg  Leu Glu Ser Thr Ala  His Leu Pro Val Thr  Trp Lys Val 
    1070                 1075                 1080             


Gln 
    


<210> 176
<211> 1084
<212> PRT
<213> Corynebacterium diphtheriae

<400> 176
Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 
1               5                   10                  15      


Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 
            20                  25                  30          


Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Lys Ile Lys 
        35                  40                  45              


Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 
    50                  55                  60                  


Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 
65                  70                  75                  80  


Ile Gln Arg Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 
                85                  90                  95      


Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 
            100                 105                 110         


Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 
        115                 120                 125             


Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 
    130                 135                 140                 


Leu Tyr Leu Pro Asp Glu Pro Ser Asp Ala Phe Lys Ala Ile Arg Glu 
145                 150                 155                 160 


Glu Ile Lys Arg Ala Ser Gly Gln Pro Val Pro Glu Thr Ala Thr Val 
                165                 170                 175     


Gly Gln Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 
            180                 185                 190         


Glu Gly Gly Val Leu Ser Ala Arg Leu Gln Gln Ser Asp His Ala Arg 
        195                 200                 205             


Glu Ile Gln Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 
    210                 215                 220                 


Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 
225                 230                 235                 240 


Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn Arg 
                245                 250                 255     


Ala Leu Lys Ala Ser Asp Ala Phe Gln Arg Tyr Arg Ile Ala Ala Leu 
            260                 265                 270         


Ile Gly Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 
        275                 280                 285             


Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Ala Pro 
    290                 295                 300                 


Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 
305                 310                 315                 320 


Arg Gly Gln Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
                325                 330                 335     


Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 
            340                 345                 350         


Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 
        355                 360                 365             


Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 
    370                 375                 380                 


Phe Asp Ser Pro Glu Gly Ala Lys Val Gln Ala Phe Phe Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 
                405                 410                 415     


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 
            420                 425                 430         


Leu Ala Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gln Glu Phe Gly 
        435                 440                 445             


Ile Glu Pro Ser Trp Thr Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 
    450                 455                 460                 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 
465                 470                 475                 480 


Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 
                485                 490                 495     


His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 
            500                 505                 510         


Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln Glu 
        515                 520                 525             


Met Gln Glu Lys Leu Asn Val Gln Gly Lys Pro Ser Arg Ala Asp Leu 
    530                 535                 540                 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
545                 550                 555                 560 


Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 
                565                 570                 575     


Arg Ala Gly Gln Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 
            580                 585                 590         


Cys His Arg Cys Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 
        595                 600                 605             


Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 
    610                 615                 620                 


Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Ala Thr Met 
                645                 650                 655     


Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
            660                 665                 670         


Asn Glu Leu Arg Ser Arg Val Ala Gln His Phe Ala Ser His Gly Thr 
        675                 680                 685             


Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 
    690                 695                 700                 


Ser Gly Ile Ser Gly Lys Leu Glu Phe Leu Asp Gly Val Gly Lys Ser 
705                 710                 715                 720 


Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 
                725                 730                 735     


Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 
            740                 745                 750         


Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr 
        755                 760                 765             


Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gln Lys 
    770                 775                 780                 


Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 
785                 790                 795                 800 


Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 
                805                 810                 815     


His Glu Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gln 
            820                 825                 830         


Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 
        835                 840                 845             


Ala Leu Thr Arg Glu Pro Asp Phe Asp Pro Lys Asp Gly Leu Pro Ala 
    850                 855                 860                 


Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 
865                 870                 875                 880 


Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 
                885                 890                 895     


Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 
            900                 905                 910         


Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 
        915                 920                 925             


Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gln Asp Leu Phe Ser Val Glu 
    930                 935                 940                 


Leu Lys Pro Gln Thr Met Ser Met Arg Gln Ala Glu Lys Lys Leu Arg 
945                 950                 955                 960 


Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 
                965                 970                 975     


Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 
            980                 985                 990         


Lys Ala Val Glu Ala Glu Leu Gly  Thr Ile Arg Arg Trp  Arg Val Asp 
        995                 1000                 1005             


Gly Phe  Phe Gly Asp Thr Arg  Leu Arg Leu Arg Pro  Leu Gln Met 
    1010                 1015                 1020             


Ser Lys  Glu Gly Ile Lys Lys  Glu Ser Ala Pro Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Lys Leu Phe 
    1040                 1045                 1050             


Ser Glu  Gly Asn Val Thr Val  Val Arg Arg Asp Ser  Leu Gly Arg 
    1055                 1060                 1065             


Val Arg  Leu Glu Ser Thr Ala  His Leu Pro Val Thr  Trp Lys Val 
    1070                 1075                 1080             


Gln 
    


<210> 177
<211> 1084
<212> PRT
<213> Corynebacterium diphtheriae

<400> 177
Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 
1               5                   10                  15      


Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 
            20                  25                  30          


Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Glu Ile Lys 
        35                  40                  45              


Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 
    50                  55                  60                  


Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 
65                  70                  75                  80  


Ile Gln Arg Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 
                85                  90                  95      


Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 
            100                 105                 110         


Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 
        115                 120                 125             


Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 
    130                 135                 140                 


Leu Tyr Leu Pro Asp Gly Pro Ser Asp Ala Phe Lys Ala Ile Arg Glu 
145                 150                 155                 160 


Glu Ile Lys Arg Ala Ser Gly Gln Pro Val Pro Glu Thr Ala Thr Val 
                165                 170                 175     


Gly Gln Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 
            180                 185                 190         


Glu Gly Gly Val Leu Ser Ala Arg Leu Gln Gln Ser Asp His Ala Arg 
        195                 200                 205             


Glu Ile Gln Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 
    210                 215                 220                 


Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 
225                 230                 235                 240 


Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn Arg 
                245                 250                 255     


Ala Leu Lys Ala Ser Asp Ala Phe Gln Arg Tyr Arg Ile Ala Ala Leu 
            260                 265                 270         


Ile Gly Asn Leu Arg Val Trp Val Asp Gly Glu Lys Arg Ile Leu Ser 
        275                 280                 285             


Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Thr Pro 
    290                 295                 300                 


Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 
305                 310                 315                 320 


Arg Gly Gln Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
                325                 330                 335     


Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 
            340                 345                 350         


Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 
        355                 360                 365             


Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 
    370                 375                 380                 


Phe Asp Ser Pro Glu Arg Ala Lys Val Gln Ala Phe Phe Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 
                405                 410                 415     


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 
            420                 425                 430         


Leu Ser Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gln Glu Phe Gly 
        435                 440                 445             


Ile Glu Pro Ser Trp Thr Pro Pro Thr Pro Arg Ile Gly Glu Pro Val 
    450                 455                 460                 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 
465                 470                 475                 480 


Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 
                485                 490                 495     


His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 
            500                 505                 510         


Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln Glu 
        515                 520                 525             


Met Gln Glu Lys Leu Asn Val Gln Gly Lys Pro Ser Arg Ala Asp Leu 
    530                 535                 540                 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
545                 550                 555                 560 


Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 
                565                 570                 575     


Arg Ala Gly Gln Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 
            580                 585                 590         


Cys His Arg Cys Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 
        595                 600                 605             


Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 
    610                 615                 620                 


Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Ala Thr Met 
                645                 650                 655     


Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
            660                 665                 670         


Asn Glu Leu Arg Ser Arg Val Ala Gln His Phe Ala Ser His Gly Thr 
        675                 680                 685             


Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 
    690                 695                 700                 


Ser Gly Ile Ser Gly Lys Leu Glu Phe Leu Asp Gly Val Gly Lys Ser 
705                 710                 715                 720 


Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 
                725                 730                 735     


Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 
            740                 745                 750         


Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr 
        755                 760                 765             


Gly Lys Asp Ala Glu His Arg Ala Thr Trp Arg Val Trp Cys Gln Lys 
    770                 775                 780                 


Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 
785                 790                 795                 800 


Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 
                805                 810                 815     


His Glu Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gln 
            820                 825                 830         


Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 
        835                 840                 845             


Ala Leu Thr Arg Glu Pro Asp Phe Asp Pro Lys Asp Gly Leu Pro Ala 
    850                 855                 860                 


Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 
865                 870                 875                 880 


Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 
                885                 890                 895     


Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 
            900                 905                 910         


Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 
        915                 920                 925             


Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gln Asp Leu Phe Ser Val Glu 
    930                 935                 940                 


Leu Lys Pro Gln Thr Met Ser Met Arg Gln Ala Glu Lys Lys Leu Arg 
945                 950                 955                 960 


Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 
                965                 970                 975     


Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 
            980                 985                 990         


Lys Ala Val Glu Ala Glu Leu Gly  Thr Ile Arg Arg Trp  Arg Val Asp 
        995                 1000                 1005             


Gly Phe  Phe Gly Asp Thr Arg  Leu Arg Leu Arg Pro  Leu Gln Met 
    1010                 1015                 1020             


Ser Lys  Glu Gly Ile Lys Lys  Glu Ser Ala Pro Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Lys Leu Phe 
    1040                 1045                 1050             


Ser Glu  Gly Asn Val Thr Val  Val Arg Arg Asp Ser  Leu Gly Arg 
    1055                 1060                 1065             


Val Arg  Leu Glu Ser Thr Ala  His Leu Pro Val Thr  Trp Lys Val 
    1070                 1075                 1080             


Gln 
    


<210> 178
<211> 1084
<212> PRT
<213> Corynebacterium diphtheriae

<400> 178
Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 
1               5                   10                  15      


Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 
            20                  25                  30          


Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Glu Ile Lys 
        35                  40                  45              


Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 
    50                  55                  60                  


Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 
65                  70                  75                  80  


Ile Gln Arg Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 
                85                  90                  95      


Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 
            100                 105                 110         


Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 
        115                 120                 125             


Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 
    130                 135                 140                 


Leu Tyr Leu Pro Asp Gly Pro Ser Asp Ala Phe Lys Ala Ile Arg Glu 
145                 150                 155                 160 


Glu Ile Lys Arg Ala Ser Gly Gln Pro Val Pro Glu Thr Ala Thr Val 
                165                 170                 175     


Gly Gln Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 
            180                 185                 190         


Glu Gly Gly Val Leu Ser Ala Arg Leu Gln Gln Ser Asp Tyr Ala Arg 
        195                 200                 205             


Glu Ile Gln Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 
    210                 215                 220                 


Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 
225                 230                 235                 240 


Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn Arg 
                245                 250                 255     


Ala Leu Lys Ala Ser Asp Ala Phe Gln Arg Tyr Arg Ile Ala Ala Leu 
            260                 265                 270         


Ile Gly Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 
        275                 280                 285             


Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Thr Pro 
    290                 295                 300                 


Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 
305                 310                 315                 320 


Arg Gly Gln Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
                325                 330                 335     


Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 
            340                 345                 350         


Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 
        355                 360                 365             


Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 
    370                 375                 380                 


Phe Asp Ser Pro Glu Gly Ala Lys Val Gln Ala Phe Phe Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 
                405                 410                 415     


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 
            420                 425                 430         


Leu Ser Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gln Glu Phe Gly 
        435                 440                 445             


Ile Glu Pro Ser Trp Thr Pro Pro Thr Pro Arg Ile Gly Glu Pro Val 
    450                 455                 460                 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 
465                 470                 475                 480 


Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 
                485                 490                 495     


His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 
            500                 505                 510         


Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln Glu 
        515                 520                 525             


Met Gln Glu Lys Leu Asn Val Gln Gly Lys Pro Ser Arg Ala Asp Leu 
    530                 535                 540                 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
545                 550                 555                 560 


Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 
                565                 570                 575     


Arg Ala Gly Gln Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 
            580                 585                 590         


Cys His Arg Cys Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 
        595                 600                 605             


Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 
    610                 615                 620                 


Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Ala Thr Met 
                645                 650                 655     


Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
            660                 665                 670         


Asn Glu Leu Arg Ser Arg Val Ala Gln His Phe Ala Ser His Gly Thr 
        675                 680                 685             


Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 
    690                 695                 700                 


Ser Gly Ile Ser Gly Lys Leu Lys Phe Phe Asp Gly Val Gly Lys Ser 
705                 710                 715                 720 


Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 
                725                 730                 735     


Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 
            740                 745                 750         


Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr 
        755                 760                 765             


Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gln Lys 
    770                 775                 780                 


Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 
785                 790                 795                 800 


Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 
                805                 810                 815     


His Lys Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Ser Ser Gln 
            820                 825                 830         


Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 
        835                 840                 845             


Ala Leu Thr Arg Glu Pro Gly Phe Asp Pro Lys Glu Gly Leu Pro Ala 
    850                 855                 860                 


Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 
865                 870                 875                 880 


Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 
                885                 890                 895     


Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 
            900                 905                 910         


Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 
        915                 920                 925             


Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gln Asp Leu Phe Ser Val Glu 
    930                 935                 940                 


Leu Lys Pro Gln Thr Met Ser Met Arg Gln Ala Glu Lys Lys Leu Arg 
945                 950                 955                 960 


Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 
                965                 970                 975     


Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 
            980                 985                 990         


Lys Ala Val Glu Ala Glu Leu Gly  Thr Ile Arg Arg Trp  Arg Val Asp 
        995                 1000                 1005             


Gly Phe  Phe Ser Pro Ser Lys  Leu Arg Leu Arg Pro  Leu Gln Met 
    1010                 1015                 1020             


Ser Lys  Glu Gly Ile Lys Lys  Glu Ser Ala Pro Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Lys Leu Phe 
    1040                 1045                 1050             


Ser Asp  Gly Asn Val Thr Val  Val Arg Arg Asp Ser  Leu Gly Arg 
    1055                 1060                 1065             


Val Arg  Leu Glu Ser Thr Ala  His Leu Pro Val Thr  Trp Lys Val 
    1070                 1075                 1080             


Gln 
    


<210> 179
<211> 1084
<212> PRT
<213> Corynebacterium diphtheriae

<400> 179
Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 
1               5                   10                  15      


Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 
            20                  25                  30          


Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Lys Met Lys 
        35                  40                  45              


Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 
    50                  55                  60                  


Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 
65                  70                  75                  80  


Ile Gln Arg Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 
                85                  90                  95      


Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 
            100                 105                 110         


Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 
        115                 120                 125             


Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 
    130                 135                 140                 


Leu Tyr Leu Pro Asp Glu Pro Ser Asp Ala Phe Lys Ser Ile Arg Glu 
145                 150                 155                 160 


Glu Ile Lys Arg Ala Ser Gly Gln Pro Val Pro Glu Thr Ala Thr Val 
                165                 170                 175     


Gly Gln Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 
            180                 185                 190         


Glu Gly Gly Val Leu Ser Ala Arg Leu Gln Gln Ser Asp His Ala Arg 
        195                 200                 205             


Glu Ile Gln Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 
    210                 215                 220                 


Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 
225                 230                 235                 240 


Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn Arg 
                245                 250                 255     


Ala Leu Lys Ala Ser Asp Ser Phe Gln Arg Tyr Arg Ile Ala Ala Leu 
            260                 265                 270         


Ile Ser Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 
        275                 280                 285             


Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Ala Pro 
    290                 295                 300                 


Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 
305                 310                 315                 320 


Arg Gly Gln Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
                325                 330                 335     


Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 
            340                 345                 350         


Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 
        355                 360                 365             


Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 
    370                 375                 380                 


Phe Asp Ser Pro Glu Gly Ala Lys Val Gln Ala Phe Phe Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 
                405                 410                 415     


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 
            420                 425                 430         


Leu Ala Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gln Glu Phe Gly 
        435                 440                 445             


Ile Glu Pro Ser Trp Thr Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 
    450                 455                 460                 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 
465                 470                 475                 480 


Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 
                485                 490                 495     


His Val Arg Asp Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 
            500                 505                 510         


Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln Glu 
        515                 520                 525             


Met Gln Glu Lys Leu Asn Val Gln Gly Lys Pro Ser Arg Ala Asp Leu 
    530                 535                 540                 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
545                 550                 555                 560 


Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 
                565                 570                 575     


Arg Ala Gly Gln Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 
            580                 585                 590         


Cys His Arg Cys Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 
        595                 600                 605             


Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 
    610                 615                 620                 


Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Ala Thr Met 
                645                 650                 655     


Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
            660                 665                 670         


Asn Glu Leu Arg Ser Arg Val Ala Gln His Phe Ala Ser His Gly Thr 
        675                 680                 685             


Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 
    690                 695                 700                 


Ser Gly Ile Ser Gly Lys Leu Glu Phe Leu Asp Gly Val Gly Lys Ser 
705                 710                 715                 720 


Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 
                725                 730                 735     


Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 
            740                 745                 750         


Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr 
        755                 760                 765             


Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gln Lys 
    770                 775                 780                 


Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 
785                 790                 795                 800 


Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 
                805                 810                 815     


His Glu Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gln 
            820                 825                 830         


Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 
        835                 840                 845             


Ala Leu Thr Arg Glu Pro Asp Phe Asp Pro Lys Asp Gly Leu Pro Ala 
    850                 855                 860                 


Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 
865                 870                 875                 880 


Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 
                885                 890                 895     


Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 
            900                 905                 910         


Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 
        915                 920                 925             


Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gln Asp Leu Phe Ser Val Glu 
    930                 935                 940                 


Leu Lys Pro Gln Thr Met Ser Met Arg Gln Ala Glu Lys Lys Leu Arg 
945                 950                 955                 960 


Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 
                965                 970                 975     


Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 
            980                 985                 990         


Lys Ala Val Glu Ala Glu Leu Gly  Thr Ile Arg Arg Trp  Arg Val Asp 
        995                 1000                 1005             


Gly Phe  Phe Gly Asp Thr Arg  Leu Arg Leu Arg Pro  Leu Gln Met 
    1010                 1015                 1020             


Ser Lys  Glu Gly Ile Lys Lys  Glu Leu Ala Pro Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Lys Leu Phe 
    1040                 1045                 1050             


Ser Glu  Gly Asn Val Thr Val  Val Arg Arg Asp Ser  Leu Gly Arg 
    1055                 1060                 1065             


Val Arg  Leu Glu Ser Thr Ala  His Leu Pro Val Thr  Trp Lys Val 
    1070                 1075                 1080             


Gln 
    


<210> 180
<211> 1089
<212> PRT
<213> Corynebacterium matruchotii


<220>
<223> Corynebacterium matruchotii ATCC 14266

<400> 180
Met Asn Ser Ala Asn Val Asn Tyr Arg Val Gly Ile Asp Val Gly Ser 
1               5                   10                  15      


Tyr Ser Leu Gly Met Ala Ala Ile Ala Ile Asp Asp Asp Gly Lys Pro 
            20                  25                  30          


Thr Glu Ile Leu Ser Ala Ile Ser Leu Ile His Asp Ser Gly Val Asp 
        35                  40                  45              


Pro Asp Ser Ala Lys Ser Ala Ala Thr Arg Leu Ala Thr Ser Gly Ile 
    50                  55                  60                  


Ala Arg Arg Thr Arg Arg Leu Tyr Arg Arg Lys Arg Lys Arg Leu Ala 
65                  70                  75                  80  


Lys Leu Asp Lys Phe Ile Ser Ser Gln Gly Trp Pro Leu Lys Glu Phe 
                85                  90                  95      


Glu Lys Tyr Glu Asp Pro Phe Tyr Pro Trp Arg Val Arg Ala Glu Leu 
            100                 105                 110         


Ala Thr Thr Ala Ile Thr Asp Gln Gln Glu Leu Gly Glu Lys Leu Ser 
        115                 120                 125             


Ile Ala Leu Arg His Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr 
    130                 135                 140                 


Ser Lys Val Thr Ala Leu Tyr Thr Val Thr Glu Pro Ser Asp Ala Phe 
145                 150                 155                 160 


Leu Ala Met Gln Glu Glu Cys Ala Lys Gln Leu Gly Arg Thr Ile Pro 
                165                 170                 175     


Glu Thr Ile Thr Val Gly Gln Leu Val Thr Gly Met Asn Leu Gly Lys 
            180                 185                 190         


Thr Arg Leu Arg Gly Glu Asn Ser Leu Leu Ala Ala Arg Pro Arg Gln 
        195                 200                 205             


Ser Asp Asn Ala Asn Glu Ile His Thr Ile Ala Lys Val Gln Gly Leu 
    210                 215                 220                 


Ser Asn Glu Leu Val Arg Gln Ile Ile Asp His Val Phe Ala Ala Glu 
225                 230                 235                 240 


Ser Pro Lys Gly Ser Ala Ala Glu Gln Val Gly Lys Asp Pro Leu Gln 
                245                 250                 255     


Pro Thr Lys Lys Arg Ala Leu Lys Ala Ser Asp Ala Phe Gln Gln Tyr 
            260                 265                 270         


Arg Ile Ala Ala Leu Ile Gly Asn Leu Arg Ile Arg Gly Gly Lys Gly 
        275                 280                 285             


Asn Arg Arg Leu Thr Thr Glu Glu Thr Arg Leu Val Phe Asp Tyr Leu 
    290                 295                 300                 


Arg Ser Leu Pro Ala Lys Gln Glu Pro Thr Trp Gln Leu Val Ala Glu 
305                 310                 315                 320 


Gln Leu Lys Ile Asp Arg Gly Asn Leu Val Gly Thr Ala Ile Met Thr 
                325                 330                 335     


Asp Asp Gly Glu Arg Ala Gly Ala Lys Pro Pro Val His Asp Thr Asn 
            340                 345                 350         


Arg Ile Met Glu Asn Thr Lys Ile Lys Pro Leu Ala Thr Trp Trp Lys 
        355                 360                 365             


Ser Ala Asp Ala Asp Ala Arg Ala Ala Met Val Lys Ala Leu Ser Asn 
    370                 375                 380                 


Ala Glu Val Asp Asp Phe Asp Ser Gln Ala Gly Ala Gln Val Gln Glu 
385                 390                 395                 400 


Phe Phe Phe Gly Ile Ser Asp Glu Asp Gln Glu Lys Leu Asp Gly Leu 
                405                 410                 415     


His Leu Pro Ile Gly Arg Ala Ala Tyr Ser Glu Asp Thr Leu Asp Arg 
            420                 425                 430         


Leu Thr Lys Arg Met Ile Gly Glu Gly Met Asp Leu Tyr Glu Ala Arg 
        435                 440                 445             


Gln Ala Glu Phe Lys Ile Ser Asn Asp Trp Ala Pro Pro Ala Pro Glu 
    450                 455                 460                 


Ile Gly Glu Arg Val Gly Asn Pro Ala Val Asp Arg Val Leu Lys Ala 
465                 470                 475                 480 


Thr Ala Arg Trp Leu Asn Ala Ala Glu Arg Gln Trp Gly Ala Pro Lys 
                485                 490                 495     


Ser Val Asn Ile Glu His Val Arg Ala Ala Phe Met Ser Glu Ser Ser 
            500                 505                 510         


Ala Arg Glu Leu Asp Arg Asp Asn Gln Gln Arg Ala Lys Arg Asn Val 
        515                 520                 525             


Lys Val Val Ala Glu Met Gln Glu Lys Leu Gly Ile Glu Gly Arg Pro 
    530                 535                 540                 


Ser Arg Ala Asp Val Trp Arg Phe Gln Ser Ile Gln Arg Gln Asn Gly 
545                 550                 555                 560 


Lys Cys Ala Tyr Cys Gly Ala Glu Ile Ser Phe Lys Asn Ser Glu Met 
                565                 570                 575     


Asp His Ile Ile Pro Gln Ala Gly Glu Gly Ser Thr Asn Thr Arg Asp 
            580                 585                 590         


Asn Leu Val Ala Val Cys Arg Glu Cys Asn Ser Ser Lys Ser Asn Ile 
        595                 600                 605             


Ala Phe Ala Val Trp Ala Glu Asn Thr Ser Arg Pro Gly Val Ser Val 
    610                 615                 620                 


Gln Lys Ala Ile Glu Arg Thr His His Trp Val Thr Asp Ser Gly Leu 
625                 630                 635                 640 


Arg Lys Pro Glu Phe Asp Lys Phe Arg Lys Gln Val Cys Asp Arg Leu 
                645                 650                 655     


Arg Arg Lys Ala Thr Asp Glu Pro Ile Asp Ala Arg Ser Leu Glu Ser 
            660                 665                 670         


Val Ala Trp Met Ala Asn Glu Leu Arg Ser Arg Ile Ala Gln Lys Phe 
        675                 680                 685             


Lys Asp Gly Asp Thr Lys Val Arg Val Tyr Lys Gly Ala Leu Thr Ala 
    690                 695                 700                 


Glu Ala Arg Arg Ala Ser Gly Ile Ser Gly Lys Leu Glu Phe Val Asp 
705                 710                 715                 720 


Gly Lys Gly Lys Ser Arg Leu Asp Arg Arg His His Ala Val Asp Ala 
                725                 730                 735     


Ala Val Val Ala Phe Thr Ser Asn Tyr Val Ala Glu Thr Leu Ala Leu 
            740                 745                 750         


Arg Ser Asn Met Lys Phe Asp Gln Glu Leu Arg Arg Lys Ala Pro Gln 
        755                 760                 765             


Trp Arg Glu Phe Thr Gly Ser Asp His Val His Gln Val Glu Trp Thr 
    770                 775                 780                 


Lys Trp Lys Tyr Arg Met Gln Ala Leu Ala Glu Leu Leu Asn Asn Ala 
785                 790                 795                 800 


Leu Val Gln Asp Arg Ile Val Val Met His Asn Leu Arg Leu Arg Leu 
                805                 810                 815     


Gly Asn Gly Ala Ala His Glu Asp Thr Ile Gly Lys Leu Thr Arg Leu 
            820                 825                 830         


Lys Val Gly Asp Ala Ile Ser Thr Thr Asp Ile Asp Arg Ala Ser Ser 
        835                 840                 845             


Glu Ala Leu Trp Cys Ala Leu Thr Arg Asp Pro Asp Tyr Asp Pro Lys 
    850                 855                 860                 


Thr Gly Leu Pro Glu Asn Pro Asn Arg Thr Ile Arg Ile His Gly Thr 
865                 870                 875                 880 


His Leu Thr Ala Ser Asp Glu Ile Thr Val Phe Pro Val Ala Ala Ala 
                885                 890                 895     


Ser Ile Pro Ile Arg Asp Gly Phe Ala Lys Leu Gly Ser Asn Tyr His 
            900                 905                 910         


His Val Arg Leu Phe Arg Val Pro Ser Gly Lys Lys Tyr Lys Tyr Cys 
        915                 920                 925             


Leu Met Gln Val Tyr Thr Val Asp Leu Leu Lys Phe Arg Lys Glu Asp 
    930                 935                 940                 


Leu Phe Thr Val Glu Leu Lys Pro Gln Thr Ile Ser Val Arg Thr Cys 
945                 950                 955                 960 


Glu Ala Leu Leu Arg Lys Ala Leu Ala Asn Gly Thr Ala Glu Tyr Leu 
                965                 970                 975     


Gly Trp Leu Val Ser Asp Asp Glu Leu Leu Ile Asp Thr Ser Ser Phe 
            980                 985                 990         


Asp Thr Pro Gly Ile Val Lys Leu  Arg Glu Glu Tyr Gly  Pro Val Asn 
        995                 1000                 1005             


Arg Trp  Arg Leu Ala Gly Leu  Thr Ser Val Thr Arg  Leu Asn Leu 
    1010                 1015                 1020             


Arg Pro  Leu Tyr Leu Ser Lys  Glu Gly Leu Lys Pro  Asn Val Asn 
    1025                 1030                 1035             


Pro Glu  Ile Lys Lys Ile Ile  Asp Asn Arg Ser Trp  Ile Ile Thr 
    1040                 1045                 1050             


Val Asn  Lys Leu Phe Ser Ser  Gly His Val Lys Ile  Ile Arg Arg 
    1055                 1060                 1065             


Asp Ala  Leu Gly Arg Pro Arg  Leu His Ser Ala Ala  His Leu Pro 
    1070                 1075                 1080             


Ile Cys  Trp Glu Val Lys 
    1085                 


<210> 181
<211> 1069
<212> PRT
<213> Corynebacterium matruchotii


<220>
<223> Corynebacterium matruchotii ATCC 33806

<400> 181
Met Ala Ala Ile Ala Ile Asp Asp Asp Gly Lys Pro Thr Glu Ile Leu 
1               5                   10                  15      


Ser Ala Ile Ser Leu Ile His Asp Ser Gly Val Asp Pro Asp Ser Ala 
            20                  25                  30          


Lys Ser Ala Ala Thr Arg Leu Ala Thr Ser Gly Ile Ala Arg Arg Thr 
        35                  40                  45              


Arg Arg Leu Tyr Arg Arg Lys Arg Lys Arg Leu Ala Lys Leu Asp Lys 
    50                  55                  60                  


Phe Ile Ser Ser Gln Gly Trp Pro Leu Lys Glu Phe Glu Lys Tyr Glu 
65                  70                  75                  80  


Asp Pro Phe Tyr Pro Trp Arg Val Arg Ala Glu Leu Ala Thr Thr Ala 
                85                  90                  95      


Ile Thr Asp Gln Gln Glu Leu Gly Glu Lys Leu Ser Ile Ala Leu Arg 
            100                 105                 110         


His Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ser Lys Val Thr 
        115                 120                 125             


Ala Leu Tyr Thr Val Thr Glu Pro Ser Asp Ala Phe Leu Ala Met Gln 
    130                 135                 140                 


Glu Glu Cys Ala Lys Gln Leu Gly Arg Thr Ile Pro Glu Thr Ile Thr 
145                 150                 155                 160 


Val Gly Gln Leu Val Thr Gly Met Asn Leu Gly Lys Thr Arg Leu Arg 
                165                 170                 175     


Gly Glu Asn Ser Leu Leu Ala Ala Arg Pro Arg Gln Ser Asp Asn Ala 
            180                 185                 190         


Asn Glu Ile His Thr Ile Ala Lys Val Gln Gly Leu Ser Asn Glu Leu 
        195                 200                 205             


Val Arg Gln Ile Ile Asp His Val Phe Ala Ala Glu Ser Pro Lys Gly 
    210                 215                 220                 


Ser Ala Ala Glu Gln Val Gly Lys Asp Pro Leu Gln Pro Thr Lys Lys 
225                 230                 235                 240 


Arg Ala Leu Lys Ala Ser Asp Ala Phe Gln Gln Tyr Arg Ile Ala Ala 
                245                 250                 255     


Leu Ile Gly Asn Leu Arg Ile Arg Gly Gly Lys Gly Asn Arg Arg Leu 
            260                 265                 270         


Thr Thr Glu Glu Thr Arg Leu Val Phe Asp Tyr Leu Arg Ser Leu Pro 
        275                 280                 285             


Ala Lys Gln Glu Pro Thr Trp Gln Leu Val Ala Glu Gln Leu Lys Ile 
    290                 295                 300                 


Asp Arg Gly Asn Leu Val Gly Thr Ala Ile Met Thr Asp Asp Gly Glu 
305                 310                 315                 320 


Arg Ala Gly Ala Lys Pro Pro Val His Asp Thr Asn Arg Ile Met Glu 
                325                 330                 335     


Asn Thr Lys Ile Lys Pro Leu Ala Thr Trp Trp Lys Ser Ala Asp Ala 
            340                 345                 350         


Asp Ala Arg Ala Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp 
        355                 360                 365             


Asp Phe Asp Ser Gln Ala Gly Ala Gln Val Gln Glu Phe Phe Phe Gly 
    370                 375                 380                 


Ile Ser Asp Glu Asp Gln Glu Lys Leu Asp Gly Leu His Leu Pro Ile 
385                 390                 395                 400 


Gly Arg Ala Ala Tyr Ser Glu Asp Thr Leu Asp Arg Leu Thr Lys Arg 
                405                 410                 415     


Met Ile Gly Glu Gly Met Asp Leu Tyr Glu Ala Arg Gln Ala Glu Phe 
            420                 425                 430         


Lys Ile Ser Asn Asp Trp Ala Pro Pro Ala Pro Glu Ile Gly Glu Arg 
        435                 440                 445             


Val Gly Asn Pro Ala Val Asp Arg Val Leu Lys Ala Thr Ala Arg Trp 
    450                 455                 460                 


Leu Asn Ala Ala Glu Arg Gln Trp Gly Ala Pro Lys Ser Val Asn Ile 
465                 470                 475                 480 


Glu His Val Arg Ala Ala Phe Met Ser Glu Ser Ser Ala Arg Glu Leu 
                485                 490                 495     


Asp Arg Asp Asn Gln Gln Arg Ala Lys Arg Asn Val Lys Val Val Ala 
            500                 505                 510         


Glu Met Gln Glu Lys Leu Gly Ile Glu Gly Arg Pro Ser Arg Ala Asp 
        515                 520                 525             


Val Trp Arg Phe Gln Ser Ile Gln Arg Gln Asn Gly Lys Cys Ala Tyr 
    530                 535                 540                 


Cys Gly Ala Glu Ile Ser Phe Lys Asn Ser Glu Met Asp His Ile Ile 
545                 550                 555                 560 


Pro Gln Val Gly Glu Gly Ser Thr Asn Thr Arg Asp Asn Leu Val Ala 
                565                 570                 575     


Val Cys Arg Glu Cys Asn Ser Ser Lys Ser Asn Ile Ala Phe Ala Val 
            580                 585                 590         


Trp Ala Glu Asn Thr Ser Arg Pro Gly Val Ser Val Gln Lys Ala Ile 
        595                 600                 605             


Glu Arg Thr His His Trp Val Thr Asp Ser Gly Leu Arg Lys Pro Glu 
    610                 615                 620                 


Phe Asp Lys Phe Arg Lys Gln Val Cys Asp Arg Leu Arg Arg Lys Ala 
625                 630                 635                 640 


Thr Asp Glu Pro Ile Asp Ala Arg Ser Leu Glu Ser Val Ala Trp Met 
                645                 650                 655     


Ala Asn Glu Leu Arg Ser Arg Ile Ala Gln Lys Phe Lys Asp Gly Asp 
            660                 665                 670         


Thr Lys Val Arg Val Tyr Lys Gly Ala Leu Thr Ala Glu Ala Arg Arg 
        675                 680                 685             


Ala Ser Gly Ile Ser Gly Lys Leu Glu Phe Val Asp Gly Lys Gly Lys 
    690                 695                 700                 


Ser Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ala Val Val Ala 
705                 710                 715                 720 


Phe Thr Ser Asn Tyr Val Ala Glu Thr Leu Ala Leu Arg Ser Asn Met 
                725                 730                 735     


Lys Phe Asp Gln Glu Leu Arg Arg Lys Ala Pro Gln Trp Arg Glu Phe 
            740                 745                 750         


Thr Gly Ser Asp His Val His Gln Val Glu Trp Thr Lys Trp Lys Tyr 
        755                 760                 765             


Arg Met Gln Ala Leu Ala Glu Leu Leu Asn Asn Ala Leu Val Gln Asp 
    770                 775                 780                 


Arg Ile Val Val Met His Asn Leu Arg Leu Arg Leu Gly Asn Gly Ala 
785                 790                 795                 800 


Ala His Glu Asp Thr Ile Gly Lys Leu Thr Arg Leu Lys Val Gly Asp 
                805                 810                 815     


Ala Ile Ser Thr Thr Asp Ile Asp Arg Ala Ser Ser Glu Ala Leu Trp 
            820                 825                 830         


Cys Ala Leu Thr Arg Asp Pro Asp Tyr Asp Pro Lys Thr Gly Leu Pro 
        835                 840                 845             


Glu Asn Pro Asn Arg Thr Ile Arg Ile His Gly Thr His Leu Thr Ala 
    850                 855                 860                 


Ser Asp Glu Ile Thr Val Phe Pro Val Ala Ala Ala Ser Ile Pro Ile 
865                 870                 875                 880 


Arg Asp Gly Phe Ala Lys Leu Gly Ser Asn Tyr His His Val Arg Leu 
                885                 890                 895     


Phe Arg Val Pro Ser Gly Lys Lys Tyr Lys Tyr Cys Leu Met Gln Val 
            900                 905                 910         


Tyr Thr Val Asp Leu Leu Lys Phe Arg Lys Glu Asp Leu Phe Thr Val 
        915                 920                 925             


Glu Leu Lys Pro Gln Thr Ile Ser Val Arg Thr Cys Glu Ala Leu Leu 
    930                 935                 940                 


Arg Lys Ala Leu Ala Asn Gly Thr Ala Glu Tyr Leu Gly Trp Leu Val 
945                 950                 955                 960 


Ser Asp Asp Glu Leu Leu Ile Asp Thr Ser Ser Phe Asp Thr Pro Gly 
                965                 970                 975     


Ile Val Lys Leu Arg Glu Glu Tyr Gly Pro Val Asn Arg Trp Arg Leu 
            980                 985                 990         


Ala Gly Leu Thr Ser Val Thr Arg  Leu Asn Leu Arg Pro  Leu Tyr Leu 
        995                 1000                 1005             


Ser Lys  Glu Gly Leu Lys Pro  Asn Val Asn Pro Glu  Ile Lys Lys 
    1010                 1015                 1020             


Ile Ile  Asp Asn Arg Ser Trp  Ile Ile Thr Val Asn  Lys Leu Phe 
    1025                 1030                 1035             


Ser Ser  Gly His Val Lys Ile  Ile Arg Arg Asp Ala  Leu Gly Arg 
    1040                 1045                 1050             


Pro Arg  Leu His Ser Ala Ala  His Leu Pro Ile Cys  Trp Glu Val 
    1055                 1060                 1065             


Lys 
    


<210> 182
<211> 1079
<212> PRT
<213> Dinoroseobacter shibae

<400> 182
Met Arg Leu Gly Leu Asp Ile Gly Thr Ser Ser Ile Gly Trp Trp Leu 
1               5                   10                  15      


Tyr Glu Thr Asp Gly Ala Gly Ser Asp Ala Arg Ile Thr Gly Val Val 
            20                  25                  30          


Asp Gly Gly Val Arg Ile Phe Ser Asp Gly Arg Asp Pro Lys Ser Gly 
        35                  40                  45              


Ala Ser Leu Ala Val Asp Arg Arg Ala Ala Arg Ala Met Arg Arg Arg 
    50                  55                  60                  


Arg Asp Arg Tyr Leu Arg Arg Arg Ala Thr Leu Met Lys Val Leu Ala 
65                  70                  75                  80  


Glu Thr Gly Leu Met Pro Ala Asp Pro Ala Glu Ala Lys Ala Leu Glu 
                85                  90                  95      


Ala Leu Asp Pro Phe Ala Leu Arg Ala Ala Gly Leu Asp Glu Pro Leu 
            100                 105                 110         


Pro Leu Pro His Leu Gly Arg Ala Leu Phe His Leu Asn Gln Arg Arg 
        115                 120                 125             


Gly Phe Lys Ser Asn Arg Lys Thr Asp Arg Gly Asp Asn Glu Ser Gly 
    130                 135                 140                 


Lys Ile Lys Asp Ala Thr Ala Arg Leu Asp Met Glu Met Met Ala Asn 
145                 150                 155                 160 


Gly Ala Arg Thr Tyr Gly Glu Phe Leu His Lys Arg Arg Gln Lys Ala 
                165                 170                 175     


Thr Asp Pro Arg His Val Pro Ser Val Arg Thr Arg Leu Ser Ile Ala 
            180                 185                 190         


Asn Arg Gly Gly Pro Asp Gly Lys Glu Glu Ala Gly Tyr Asp Phe Tyr 
        195                 200                 205             


Pro Asp Arg Arg His Leu Glu Glu Glu Phe His Lys Leu Trp Ala Ala 
    210                 215                 220                 


Gln Gly Ala His His Pro Glu Leu Thr Glu Thr Leu Arg Asp Leu Leu 
225                 230                 235                 240 


Phe Glu Lys Ile Phe Phe Gln Arg Pro Leu Lys Glu Pro Glu Val Gly 
                245                 250                 255     


Leu Cys Leu Phe Ser Gly His His Gly Val Pro Pro Lys Asp Pro Arg 
            260                 265                 270         


Leu Pro Lys Ala His Pro Leu Thr Gln Arg Arg Val Leu Tyr Glu Thr 
        275                 280                 285             


Val Asn Gln Leu Arg Val Thr Ala Asp Gly Arg Glu Ala Arg Pro Leu 
    290                 295                 300                 


Thr Arg Glu Glu Arg Asp Gln Val Ile His Ala Leu Asp Asn Lys Lys 
305                 310                 315                 320 


Pro Thr Lys Ser Leu Ser Ser Met Val Leu Lys Leu Pro Ala Leu Ala 
                325                 330                 335     


Lys Val Leu Lys Leu Arg Asp Gly Glu Arg Phe Thr Leu Glu Thr Gly 
            340                 345                 350         


Val Arg Asp Ala Ile Ala Cys Asp Pro Leu Arg Ala Ser Pro Ala His 
        355                 360                 365             


Pro Asp Arg Phe Gly Pro Arg Trp Ser Ile Leu Asp Ala Asp Ala Gln 
    370                 375                 380                 


Trp Glu Val Ile Ser Arg Ile Arg Arg Val Gln Ser Asp Ala Glu His 
385                 390                 395                 400 


Ala Ala Leu Val Asp Trp Leu Thr Glu Ala His Gly Leu Asp Arg Ala 
                405                 410                 415     


His Ala Glu Ala Thr Ala His Ala Pro Leu Pro Asp Gly Tyr Gly Arg 
            420                 425                 430         


Leu Gly Leu Thr Ala Thr Thr Arg Ile Leu Tyr Gln Leu Thr Ala Asp 
        435                 440                 445             


Val Val Thr Tyr Ala Asp Ala Val Lys Ala Cys Gly Trp His His Ser 
    450                 455                 460                 


Asp Gly Arg Thr Gly Glu Cys Phe Asp Arg Leu Pro Tyr Tyr Gly Glu 
465                 470                 475                 480 


Val Leu Glu Arg His Val Ile Pro Gly Ser Tyr His Pro Asp Asp Asp 
                485                 490                 495     


Asp Ile Thr Arg Phe Gly Arg Ile Thr Asn Pro Thr Val His Ile Gly 
            500                 505                 510         


Leu Asn Gln Leu Arg Arg Leu Val Asn Arg Ile Ile Glu Thr His Gly 
        515                 520                 525             


Lys Pro His Gln Ile Val Val Glu Leu Ala Arg Asp Leu Lys Lys Ser 
    530                 535                 540                 


Glu Glu Gln Lys Arg Ala Asp Ile Lys Arg Ile Arg Asp Thr Thr Glu 
545                 550                 555                 560 


Ala Ala Lys Lys Arg Ser Glu Lys Leu Glu Glu Leu Glu Ile Glu Asp 
                565                 570                 575     


Asn Gly Arg Asn Arg Met Leu Leu Arg Leu Trp Glu Asp Leu Asn Pro 
            580                 585                 590         


Asp Asp Ala Met Arg Arg Phe Cys Pro Tyr Thr Gly Thr Arg Ile Ser 
        595                 600                 605             


Ala Ala Met Ile Phe Asp Gly Ser Cys Asp Val Asp His Ile Leu Pro 
    610                 615                 620                 


Tyr Ser Arg Thr Leu Asp Asp Ser Phe Pro Asn Arg Thr Leu Cys Leu 
625                 630                 635                 640 


Arg Glu Ala Asn Arg Gln Lys Arg Asn Gln Thr Pro Trp Gln Ala Trp 
                645                 650                 655     


Gly Asp Thr Pro His Trp His Ala Ile Ala Ala Asn Leu Lys Asn Leu 
            660                 665                 670         


Pro Glu Asn Lys Arg Trp Arg Phe Ala Pro Asp Ala Met Thr Arg Phe 
        675                 680                 685             


Glu Gly Glu Asn Gly Phe Leu Asp Arg Ala Leu Lys Asp Thr Gln Tyr 
    690                 695                 700                 


Leu Ala Arg Ile Ser Arg Ser Tyr Leu Asp Thr Leu Phe Thr Lys Gly 
705                 710                 715                 720 


Gly His Val Trp Val Val Pro Gly Arg Phe Thr Glu Met Leu Arg Arg 
                725                 730                 735     


His Trp Gly Leu Asn Ser Leu Leu Ser Asp Ala Gly Arg Gly Ala Val 
            740                 745                 750         


Lys Ala Lys Asn Arg Thr Asp His Arg His His Ala Ile Asp Ala Ala 
        755                 760                 765             


Val Ile Ala Ala Thr Asp Pro Gly Leu Leu Asn Arg Ile Ser Arg Ala 
    770                 775                 780                 


Ala Gly Gln Gly Glu Ala Ala Gly Gln Ser Ala Glu Leu Ile Ala Arg 
785                 790                 795                 800 


Asp Thr Pro Pro Pro Trp Glu Gly Phe Arg Asp Asp Leu Arg Val Arg 
                805                 810                 815     


Leu Asp Arg Ile Ile Val Ser His Arg Ala Asp His Gly Arg Ile Asp 
            820                 825                 830         


His Ala Ala Arg Lys Gln Gly Arg Asp Ser Thr Ala Gly Gln Leu His 
        835                 840                 845             


Gln Glu Thr Ala Tyr Ser Ile Val Asp Asp Ile His Val Ala Ser Arg 
    850                 855                 860                 


Thr Asp Leu Leu Ser Leu Lys Pro Ala Gln Leu Leu Asp Glu Pro Gly 
865                 870                 875                 880 


Arg Ser Gly Gln Val Arg Asp Pro Gln Leu Arg Lys Ala Leu Arg Val 
                885                 890                 895     


Ala Thr Gly Gly Lys Thr Gly Lys Asp Phe Glu Asn Ala Leu Arg Tyr 
            900                 905                 910         


Phe Ala Ser Lys Pro Gly Pro Tyr Gln Ala Ile Arg Arg Val Arg Ile 
        915                 920                 925             


Ile Lys Pro Leu Gln Ala Gln Ala Arg Val Pro Val Pro Ala Gln Asp 
    930                 935                 940                 


Pro Ile Lys Ala Tyr Gln Gly Gly Ser Asn His Leu Phe Glu Ile Trp 
945                 950                 955                 960 


Arg Leu Pro Asp Gly Glu Ile Glu Ala Gln Val Ile Thr Ser Phe Glu 
                965                 970                 975     


Ala His Thr Leu Glu Gly Glu Lys Arg Pro His Pro Ala Ala Lys Arg 
            980                 985                 990         


Leu Leu Arg Val His Lys Gly Asp  Met Val Ala Leu Glu  Arg Asp Gly 
        995                 1000                 1005             


Arg Arg  Val Val Gly His Val  Gln Lys Met Asp Ile  Ala Asn Gly 
    1010                 1015                 1020             


Leu Phe  Ile Val Pro His Asn  Glu Ala Asn Ala Asp  Thr Arg Asn 
    1025                 1030                 1035             


Asn Asp  Lys Ser Asp Pro Phe  Lys Trp Ile Gln Ile  Gly Ala Arg 
    1040                 1045                 1050             


Pro Ala  Ile Ala Ser Gly Ile  Arg Arg Val Ser Val  Asp Glu Ile 
    1055                 1060                 1065             


Gly Arg  Leu Arg Asp Gly Gly  Thr Arg Pro Ile 
    1070                 1075                 


<210> 183
<211> 1332
<212> PRT
<213> Dolosigranulum pigrum


<220>
<223> Dolosigranulum pigrum ATCC 51524

<400> 183
Met Gln Lys Asn Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Lys Asp Asp Tyr Thr Leu Ile Arg Lys Arg Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Ile Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Glu Thr Ala Lys Glu Thr Arg Leu 
    50                  55                  60                  


Lys Arg Gly Thr Arg Arg Arg Tyr Gln Arg Arg Arg Asn Arg Leu Ile 
65                  70                  75                  80  


Tyr Leu Gln Asp Ile Phe Gln Gln Pro Met Leu Ala Ile Asp Glu Asn 
                85                  90                  95      


Phe Phe His Arg Leu Asp Asp Ser Phe Phe Val Pro Asp Asp Lys Ser 
            100                 105                 110         


Tyr Asp Arg His Pro Ile Phe Gly Ser Leu Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Asn Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Ala Asp Leu Arg Leu Val Tyr Thr Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Thr Ser Ile Ser Glu Thr Phe Glu Gln Phe Leu Asp Thr Tyr 
            180                 185                 190         


Ser Asp Ile Phe Lys Glu Gln Leu Val Gly Asp Ile Ser Lys Val Glu 
        195                 200                 205             


Glu Ile Leu Ser Ser Lys Gln Ser Arg Ser Arg Lys His Glu Gln Ile 
    210                 215                 220                 


Met Ala Leu Phe Pro Asn Glu Asn Lys Leu Gly Asn Phe Gly Arg Phe 
225                 230                 235                 240 


Met Met Leu Ile Val Gly Asn Thr Ser Asn Phe Lys Pro Val Phe Asp 
                245                 250                 255     


Leu Asp Asp Glu Tyr Lys Leu Lys Leu Ser Asp Glu Thr Tyr Glu Glu 
            260                 265                 270         


Asp Leu Asp Thr Leu Leu Gly Met Thr Asp Asp Val Phe Leu Asp Val 
        275                 280                 285             


Phe Met Ala Ala Lys Asn Val Tyr Asp Ala Val Glu Met Ser Ala Ile 
    290                 295                 300                 


Ile Ser Thr Asp Thr Gly Asn Ser Lys Ala Val Leu Ser Asn Gln Met 
305                 310                 315                 320 


Ile Asn Phe Tyr Asp Glu His Lys Val Asp Leu Ala Gln Leu Lys Gln 
                325                 330                 335     


Phe Phe Lys Thr His Leu Pro Asp Lys Tyr Tyr Glu Cys Phe Ser Asp 
            340                 345                 350         


Pro Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn Gln 
        355                 360                 365             


Glu Asp Phe Tyr Lys Tyr Ile Glu Lys Val Met Lys Thr Ile Lys Ser 
    370                 375                 380                 


Asp Lys Lys Asp Tyr Phe Leu Asp Lys Ile Asp Arg Glu Val Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Ser Phe Tyr Asn Ser Val Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Gln Ala Ile Leu Asp Arg Gln Ser Gln Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Ala Glu Asn Arg Asp Lys Ile Glu Ser Leu Val Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Thr Val Ser Asp Gln Ser Glu Phe 
    450                 455                 460                 


Ala Trp Met Glu Arg Gln Ser Asp Glu Pro Ile Arg Pro Trp Asn Phe 
465                 470                 475                 480 


Asp Glu Ile Val Asn Lys Glu Arg Ser Ala Glu Lys Phe Ile Glu Arg 
                485                 490                 495     


Met Thr Asn Met Asp Thr Tyr Leu Leu Glu Glu Lys Val Leu Pro Lys 
            500                 505                 510         


Arg Ser Leu Leu Tyr Gln Thr Phe Glu Val Tyr Asn Glu Leu Thr Lys 
        515                 520                 525             


Val Arg Tyr Thr Asn Glu Gln Gly Lys Thr Glu Lys Leu Asn Arg Gln 
    530                 535                 540                 


Gln Lys Ala Glu Ile Ile Glu Thr Leu Phe Lys Gln Lys Asn Arg Val 
545                 550                 555                 560 


Arg Glu Lys Asp Ile Ala Asn Tyr Leu Glu Gln Tyr Gly Tyr Val Asp 
                565                 570                 575     


Gly Thr Asp Ile Lys Gly Val Glu Asp Lys Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr Asn Asp Leu Ala Lys Ile Asp Gly Ala Lys Ala Tyr Leu Asp 
        595                 600                 605             


Asp Pro Glu Tyr Ala Asp Val Trp Glu Asp Ile Ile Lys Ile Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Lys Ala Met Arg Lys Lys Gln Leu Gln Thr Tyr Ser 
625                 630                 635                 640 


Asp Thr Leu Ser Pro Glu Ile Leu Lys Lys Leu Glu Arg Lys His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Phe Ser Lys Lys Leu Ile Asn Gly Leu Arg Asp 
            660                 665                 670         


Glu Gly Ser Asn Lys Thr Ile Leu Asp Tyr Leu Lys Ser Asp Glu Gly 
        675                 680                 685             


Ser Ser Gly Pro Thr Asn Arg Asn Phe Met Gln Leu Ile Arg Asp Asn 
    690                 695                 700                 


Thr Leu Ser Phe Lys Lys Lys Ile Glu Asp Ala Gln Thr Ile Glu Asp 
705                 710                 715                 720 


Thr Thr His Ile Tyr Asp Thr Val Ala Glu Leu Pro Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Arg Gln Ala Leu Lys Ile Val Glu Glu Ile Ile 
            740                 745                 750         


Asp Ile Ile Gly Tyr Glu Pro Glu Asn Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Ser Gln Thr Thr Lys Lys Gly Lys Asp Leu Ser Lys Glu Arg Leu 
    770                 775                 780                 


Glu Lys Leu Thr Glu Ala Ile Lys Glu Phe Asp Gly Pro Ser Asp Val 
785                 790                 795                 800 


Lys Val Lys Asp Leu Lys Asn Glu Asn Leu Arg Asn Asp Arg Leu Tyr 
                805                 810                 815     


Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Asn Glu Pro Leu 
            820                 825                 830         


Asp Ile Asn Asn Leu Ser Lys Tyr Asp Ile Asp His Ile Ile Pro Gln 
        835                 840                 845             


Ser Phe Thr Thr Asp Asn Ser Ile Asp Asn Lys Val Leu Val Ser Arg 
    850                 855                 860                 


Thr Lys Asn Gln Gly Asn Lys Ser Asp Asp Val Pro Ser Ile Asn Ile 
865                 870                 875                 880 


Val His Lys Met Lys Pro Phe Trp Arg Gln Leu His Lys Ala Gly Leu 
                885                 890                 895     


Ile Ser Asp Arg Lys Phe Lys Asn Leu Thr Lys Ala Glu His Gly Gly 
            900                 905                 910         


Leu Thr Glu Ala Asp Arg Ala His Phe Leu Asn Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Asn Leu Leu Asp Ser Gln Tyr 
    930                 935                 940                 


Asn Thr Ala Glu Glu Gln Arg Ile Asn Ile Val Leu Leu Lys Ser Ser 
945                 950                 955                 960 


Met Thr Ser Arg Phe Arg Lys Glu Phe Lys Leu Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Gly His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Ala Thr Thr Ile Met Lys Val Tyr  Pro Asn Leu Lys Pro  Gln Phe Val 
        995                 1000                 1005             


Tyr Gly  Gln Tyr Lys Lys Thr  Ser Met Phe Lys Glu  Glu Lys Ala 
    1010                 1015                 1020             


Thr Ala  Arg Lys His Phe Tyr  Ser Asn Ile Thr Lys  Phe Phe Lys 
    1025                 1030                 1035             


Lys Glu  Lys Val Val Asn Glu  Glu Thr Gly Glu Ile  Leu Trp Asp 
    1040                 1045                 1050             


Thr Glu  Arg His Leu Ser Thr  Ile Lys Arg Val Leu  Ser Trp Lys 
    1055                 1060                 1065             


Gln Met  Asn Ile Val Lys Lys  Val Glu Lys Gln Lys  Gly Gln Leu 
    1070                 1075                 1080             


Trp Lys  Glu Thr Ile Tyr Pro  Lys Gly Asp Ser Ser  Lys Leu Ile 
    1085                 1090                 1095             


Pro Val  Lys Glu Gly Met Asp  Pro Gln Lys Tyr Gly  Gly Leu Ser 
    1100                 1105                 1110             


Gln Val  Ser Glu Ala Phe Ala  Val Val Ile Thr His  Glu Lys Gly 
    1115                 1120                 1125             


Lys Lys  Lys Gln Leu Lys Ser  Asp Leu Ile Ser Ile  Pro Ile Val 
    1130                 1135                 1140             


Asp Gln  Lys Ala Tyr Glu Gln  His Pro Thr Ala Tyr  Leu Glu Glu 
    1145                 1150                 1155             


Ala Gly  Tyr Asn Asn Pro Thr  Val Leu His Glu Leu  Phe Lys Tyr 
    1160                 1165                 1170             


Gln Leu  Phe Glu Leu Glu Asp  Gly Ser Arg Arg Met  Ile Ala Ser 
    1175                 1180                 1185             


Ala Lys  Glu Phe Gln Lys Gly  Asn Gln Met Val Leu  Pro Leu Glu 
    1190                 1195                 1200             


Leu Val  Glu Leu Leu Tyr His  Ala Asn Arg Tyr Asp  Lys Val Lys 
    1205                 1210                 1215             


Phe Pro  Asp Ser Ile Glu Tyr  Val His Asp Asn Leu  Ala Lys Phe 
    1220                 1225                 1230             


Asp Asp  Leu Leu Glu Tyr Val  Ile Asp Phe Ser Asn  Lys Tyr Ile 
    1235                 1240                 1245             


Asn Ala  Asp Lys Asn Val Gln  Lys Ile Gln Lys Ile  Tyr Lys Glu 
    1250                 1255                 1260             


His Gly  Thr Glu Asp Val Glu  Leu Thr Val Glu Ser  Phe Val Asn 
    1265                 1270                 1275             


Leu Met  Thr Phe Thr Ala Met  Gly Ala Pro Ala Thr  Phe Lys Phe 
    1280                 1285                 1290             


Tyr Gly  Glu Ser Ile Thr Arg  Ser Arg Tyr Thr Ser  Ile Thr Glu 
    1295                 1300                 1305             


Phe Arg  Gly Ser Thr Leu Ile  Phe Gln Ser Ile Thr  Gly Leu Tyr 
    1310                 1315                 1320             


Glu Thr  Arg Tyr Lys Leu Glu  Asp Asn 
    1325                 1330         


<210> 184
<211> 1340
<212> PRT
<213> Dorea longicatena


<220>
<223> Dorea longicatena DSM 13814

<400> 184
Met Glu Gln Glu Tyr Tyr Leu Gly Leu Asp Met Gly Thr Gly Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Thr Asp Ser Glu Tyr His Val Leu Arg Lys His Gly 
            20                  25                  30          


Lys Ala Leu Trp Gly Val Arg Leu Phe Glu Ser Ala Ser Thr Ala Glu 
        35                  40                  45              


Glu Arg Arg Met Phe Arg Thr Ser Arg Arg Arg Leu Asp Arg Arg Asn 
    50                  55                  60                  


Trp Arg Ile Glu Ile Leu Gln Glu Ile Phe Ala Glu Glu Ile Ser Lys 
65                  70                  75                  80  


Lys Asp Pro Gly Phe Phe Leu Arg Met Lys Glu Ser Lys Tyr Tyr Pro 
                85                  90                  95      


Glu Asp Lys Arg Asp Ile Asn Gly Asn Cys Pro Glu Leu Pro Tyr Ala 
            100                 105                 110         


Leu Phe Val Asp Asp Asp Phe Thr Asp Lys Asp Tyr His Lys Lys Phe 
        115                 120                 125             


Pro Thr Ile Tyr His Leu Arg Lys Met Leu Met Asn Thr Glu Glu Thr 
    130                 135                 140                 


Pro Asp Ile Arg Leu Val Tyr Leu Ala Ile His His Met Met Lys His 
145                 150                 155                 160 


Arg Gly His Phe Leu Leu Ser Gly Asp Ile Asn Glu Ile Lys Glu Phe 
                165                 170                 175     


Gly Thr Thr Phe Ser Lys Leu Leu Glu Asn Ile Lys Asn Glu Glu Leu 
            180                 185                 190         


Asp Trp Asn Leu Glu Leu Gly Lys Glu Glu Tyr Ala Val Val Glu Ser 
        195                 200                 205             


Ile Leu Lys Asp Asn Met Leu Asn Arg Ser Thr Lys Lys Thr Arg Leu 
    210                 215                 220                 


Ile Lys Ala Leu Lys Ala Lys Ser Ile Cys Glu Lys Ala Val Leu Asn 
225                 230                 235                 240 


Leu Leu Ala Gly Gly Thr Val Lys Leu Ser Asp Ile Phe Gly Leu Glu 
                245                 250                 255     


Glu Leu Asn Glu Thr Glu Arg Pro Lys Ile Ser Phe Ala Asp Asn Gly 
            260                 265                 270         


Tyr Asp Asp Tyr Ile Gly Glu Val Glu Asn Glu Leu Gly Glu Gln Phe 
        275                 280                 285             


Tyr Ile Ile Glu Thr Ala Lys Ala Val Tyr Asp Trp Ala Val Leu Val 
    290                 295                 300                 


Glu Ile Leu Gly Lys Tyr Thr Ser Ile Ser Glu Ala Lys Val Ala Thr 
305                 310                 315                 320 


Tyr Glu Lys His Lys Ser Asp Leu Gln Phe Leu Lys Lys Ile Val Arg 
                325                 330                 335     


Lys Tyr Leu Thr Lys Glu Glu Tyr Lys Asp Ile Phe Val Ser Thr Ser 
            340                 345                 350         


Asp Lys Leu Lys Asn Tyr Ser Ala Tyr Ile Gly Met Thr Lys Ile Asn 
        355                 360                 365             


Gly Lys Lys Val Asp Leu Gln Ser Lys Arg Cys Ser Lys Glu Glu Phe 
    370                 375                 380                 


Tyr Asp Phe Ile Lys Lys Asn Val Leu Lys Lys Leu Glu Gly Gln Pro 
385                 390                 395                 400 


Glu Tyr Glu Tyr Leu Lys Glu Glu Leu Glu Arg Glu Thr Phe Leu Pro 
                405                 410                 415     


Lys Gln Val Asn Arg Asp Asn Gly Val Ile Pro Tyr Gln Ile His Leu 
            420                 425                 430         


Tyr Glu Leu Lys Lys Ile Leu Gly Asn Leu Arg Asp Lys Ile Asp Leu 
        435                 440                 445             


Ile Lys Glu Asn Glu Asp Lys Leu Val Gln Leu Phe Glu Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Asn Lys Ile Asp Asp Gly Lys Glu Gly 
465                 470                 475                 480 


Lys Phe Thr Trp Ala Val Arg Lys Ser Asn Glu Lys Ile Tyr Pro Trp 
                485                 490                 495     


Asn Phe Glu Asn Val Val Asp Ile Glu Ala Ser Ala Glu Lys Phe Ile 
            500                 505                 510         


Arg Arg Met Thr Asn Lys Cys Thr Tyr Leu Met Gly Glu Asp Val Leu 
        515                 520                 525             


Pro Lys Asp Ser Leu Leu Tyr Ser Lys Tyr Met Val Leu Asn Glu Leu 
    530                 535                 540                 


Asn Asn Val Lys Leu Asp Gly Glu Lys Leu Ser Val Glu Leu Lys Gln 
545                 550                 555                 560 


Arg Leu Tyr Thr Asp Val Phe Cys Lys Tyr Arg Lys Val Thr Val Lys 
                565                 570                 575     


Lys Ile Lys Asn Tyr Leu Lys Cys Glu Gly Ile Ile Ser Gly Asn Val 
            580                 585                 590         


Glu Ile Thr Gly Ile Asp Gly Asp Phe Lys Ala Ser Leu Thr Ala Tyr 
        595                 600                 605             


His Asp Phe Lys Glu Ile Leu Thr Gly Thr Glu Leu Ala Lys Lys Asp 
    610                 615                 620                 


Lys Glu Asn Ile Ile Thr Asn Ile Val Leu Phe Gly Asp Asp Lys Lys 
625                 630                 635                 640 


Leu Leu Lys Lys Arg Leu Asn Arg Leu Tyr Pro Gln Ile Thr Pro Asn 
                645                 650                 655     


Gln Leu Lys Lys Ile Cys Ala Leu Ser Tyr Thr Gly Trp Gly Arg Phe 
            660                 665                 670         


Ser Lys Lys Phe Leu Glu Glu Ile Thr Ala Pro Asp Pro Glu Thr Gly 
        675                 680                 685             


Glu Val Trp Asn Ile Ile Thr Ala Leu Trp Glu Ser Asn Asn Asn Leu 
    690                 695                 700                 


Met Gln Leu Leu Ser Asn Glu Tyr Arg Phe Met Glu Glu Val Glu Thr 
705                 710                 715                 720 


Tyr Asn Met Gly Lys Gln Thr Lys Thr Leu Ser Tyr Glu Thr Val Glu 
                725                 730                 735     


Asn Met Tyr Val Ser Pro Ser Val Lys Arg Gln Ile Trp Gln Thr Leu 
            740                 745                 750         


Lys Ile Val Lys Glu Leu Glu Lys Val Met Lys Glu Ser Pro Lys Arg 
        755                 760                 765             


Val Phe Ile Glu Met Ala Arg Glu Lys Gln Glu Ser Lys Arg Thr Glu 
    770                 775                 780                 


Ser Arg Lys Lys Gln Leu Ile Asp Leu Tyr Lys Ala Cys Lys Asn Glu 
785                 790                 795                 800 


Glu Lys Asp Trp Val Lys Glu Leu Gly Asp Gln Glu Glu Gln Lys Leu 
                805                 810                 815     


Arg Ser Asp Lys Leu Tyr Leu Tyr Tyr Thr Gln Lys Gly Arg Cys Met 
            820                 825                 830         


Tyr Ser Gly Glu Val Ile Glu Leu Lys Asp Leu Trp Asp Asn Thr Lys 
        835                 840                 845             


Tyr Asp Ile Asp His Ile Tyr Pro Gln Ser Lys Thr Met Asp Asp Ser 
    850                 855                 860                 


Leu Asn Asn Arg Val Leu Val Lys Lys Lys Tyr Asn Ala Thr Lys Ser 
865                 870                 875                 880 


Asp Lys Tyr Pro Leu Asn Glu Asn Ile Arg His Glu Arg Lys Gly Phe 
                885                 890                 895     


Trp Lys Ser Leu Leu Asp Gly Gly Phe Ile Ser Lys Glu Lys Tyr Glu 
            900                 905                 910         


Arg Leu Ile Arg Asn Thr Glu Leu Ser Pro Glu Glu Leu Ala Gly Phe 
        915                 920                 925             


Ile Glu Arg Gln Ile Val Glu Thr Arg Gln Ser Thr Lys Ala Val Ala 
    930                 935                 940                 


Glu Ile Leu Lys Gln Val Phe Pro Glu Ser Glu Ile Val Tyr Val Lys 
945                 950                 955                 960 


Ala Gly Thr Val Ser Arg Phe Arg Lys Asp Phe Glu Leu Leu Lys Val 
                965                 970                 975     


Arg Glu Val Asn Asp Leu His His Ala Lys Asp Ala Tyr Leu Asn Ile 
            980                 985                 990         


Val Val Gly Asn Ser Tyr Tyr Val  Lys Phe Thr Lys Asn  Ala Ser Trp 
        995                 1000                 1005             


Phe Ile  Lys Glu Asn Pro Gly  Arg Thr Tyr Asn Leu  Lys Lys Met 
    1010                 1015                 1020             


Phe Thr  Ser Gly Trp Asn Ile  Glu Arg Asn Gly Glu  Val Ala Trp 
    1025                 1030                 1035             


Glu Val  Gly Lys Lys Gly Thr  Ile Val Thr Val Lys  Gln Ile Met 
    1040                 1045                 1050             


Asn Lys  Asn Asn Ile Leu Val  Thr Arg Gln Val His  Glu Ala Lys 
    1055                 1060                 1065             


Gly Gly  Leu Phe Asp Gln Gln  Ile Met Lys Lys Gly  Lys Gly Gln 
    1070                 1075                 1080             


Ile Ala  Ile Lys Glu Thr Asp  Glu Arg Leu Ala Ser  Ile Glu Lys 
    1085                 1090                 1095             


Tyr Gly  Gly Tyr Asn Lys Ala  Ala Gly Ala Tyr Phe  Met Leu Val 
    1100                 1105                 1110             


Glu Ser  Lys Asp Lys Lys Gly  Lys Thr Ile Arg Thr  Ile Glu Phe 
    1115                 1120                 1125             


Ile Pro  Leu Tyr Leu Lys Asn  Lys Ile Glu Ser Asp  Glu Ser Ile 
    1130                 1135                 1140             


Ala Leu  Asn Phe Leu Glu Lys  Gly Arg Gly Leu Lys  Glu Pro Lys 
    1145                 1150                 1155             


Ile Leu  Leu Lys Lys Ile Lys  Ile Asp Thr Leu Phe  Asp Val Asp 
    1160                 1165                 1170             


Gly Phe  Lys Met Trp Leu Ser  Gly Arg Thr Gly Asp  Arg Leu Leu 
    1175                 1180                 1185             


Phe Lys  Cys Ala Asn Gln Leu  Ile Leu Asp Glu Lys  Ile Ile Val 
    1190                 1195                 1200             


Thr Met  Lys Lys Ile Val Lys  Phe Ile Gln Arg Arg  Gln Glu Asn 
    1205                 1210                 1215             


Arg Glu  Leu Lys Leu Ser Asp  Lys Asp Gly Ile Asp  Asn Glu Val 
    1220                 1225                 1230             


Leu Met  Glu Ile Tyr Asn Thr  Phe Val Asp Lys Leu  Glu Asn Thr 
    1235                 1240                 1245             


Val Tyr  Arg Ile Arg Leu Ser  Glu Gln Ala Lys Thr  Leu Ile Asp 
    1250                 1255                 1260             


Lys Gln  Lys Glu Phe Glu Arg  Leu Ser Leu Glu Asp  Lys Ser Ser 
    1265                 1270                 1275             


Thr Leu  Phe Glu Ile Leu His  Ile Phe Gln Cys Gln  Ser Ser Ala 
    1280                 1285                 1290             


Ala Asn  Leu Lys Met Ile Gly  Gly Pro Gly Lys Ala  Gly Ile Leu 
    1295                 1300                 1305             


Val Met  Asn Asn Asn Ile Ser  Lys Cys Asn Lys Ile  Ser Ile Ile 
    1310                 1315                 1320             


Asn Gln  Ser Pro Thr Gly Ile  Phe Glu Asn Glu Ile  Asp Leu Leu 
    1325                 1330                 1335             


Lys Ile  
    1340 


<210> 185
<211> 1380
<212> PRT
<213> Eggerthella sp.


<220>
<223> Eggerthella sp. YY7918

<400> 185
Met Asn Leu Arg His Val Gly Asn Tyr Asn Ile Gly Leu Asp Met Gly 
1               5                   10                  15      


Thr Ala Ser Val Gly Trp Ala Ala Ile Asp Glu Gln Gly Glu Leu Leu 
            20                  25                  30          


His Phe Lys Gly Lys Pro Thr Trp Gly Ser Arg Leu Phe Asp Ser Ala 
        35                  40                  45              


Asn Thr Ala Ala Thr Ala Arg Met Pro Arg Gly Gln Arg Arg Arg Tyr 
    50                  55                  60                  


Ile Arg Arg Arg Trp Arg Leu Asp Leu Leu Gln Lys Phe Phe Ser Glu 
65                  70                  75                  80  


Glu Met Ala Glu Lys Asp Pro Glu Phe Phe Ile Arg Leu Arg Gln Ser 
                85                  90                  95      


Ser Leu Trp Pro Glu Asp Arg Glu Gly Gly His Thr Ala Tyr His Trp 
            100                 105                 110         


Pro Leu Phe Asn Asp Ser Asp Phe Asn Glu Lys Glu Tyr Tyr Glu Lys 
        115                 120                 125             


Phe Pro Thr Ile Phe His Leu Arg Gln Trp Leu Met Glu Thr Asp Glu 
    130                 135                 140                 


Lys Ala Asp Ile Arg Leu Ile Tyr Leu Ala Phe His Asn Ile Val Lys 
145                 150                 155                 160 


His Arg Gly Asn Phe Leu Gln Glu Asn Asn Asp Ser Leu Ser Ala Gln 
                165                 170                 175     


Asn Ala Asn Met Arg Glu Ser Leu Glu Ser Phe Cys Ile Ala Leu Glu 
            180                 185                 190         


Glu Trp Cys Asp Glu Lys Glu Leu Thr Cys Ser Cys Asp Pro Gln Lys 
        195                 200                 205             


Leu Glu His Leu Phe Lys Glu Val Lys Tyr Arg Ser Asp Ile Arg Asp 
    210                 215                 220                 


Gly Phe Ala Ala Leu Leu Gly Leu Ala Cys Ser Gly Glu Asn Glu Val 
225                 230                 235                 240 


Asp Val Lys Ala Met Ala Lys Glu Met Gly Lys Ala Ile Val Gly Tyr 
                245                 250                 255     


Lys Ala Asp Phe Ser Lys Ile Phe Thr Glu Cys Asp Lys Glu Gly Ser 
            260                 265                 270         


Ser Phe Arg Leu Ser Asp Asp Glu Gly Pro Glu Ala Phe Leu Asp Ile 
        275                 280                 285             


Cys Pro Asp Asp Gly Ile Ala Leu Phe Glu Ala Ile Gln Met Val Tyr 
    290                 295                 300                 


Ser Ser Phe Ile Leu Thr Gly Met Leu Thr Glu Lys Gly Leu Ser Leu 
305                 310                 315                 320 


Ser Lys Ile Ser Ala Tyr Asn Gln Tyr Gly Gln Asp Leu Glu Ser Leu 
                325                 330                 335     


Lys Ala Leu Val Lys Glu Tyr Val Pro Asn Glu Tyr Ser Ser Phe Phe 
            340                 345                 350         


Arg Gly Pro Thr Tyr Ser Gly Ser Thr Glu Tyr Asp Pro Ser Lys Ala 
        355                 360                 365             


Gln Gly Tyr Thr Arg Tyr Asn Leu Gly Pro Ser Lys Lys Gly Ser Gly 
    370                 375                 380                 


Ala Lys Pro Met Ala Tyr Glu Asp Phe Lys Lys Ser Val Glu Gln Leu 
385                 390                 395                 400 


Phe Ala Asn Thr Asn Ala Ile Asn Asp Glu Arg Tyr Lys Glu Met Met 
                405                 410                 415     


Gly Arg Phe Ala Glu Glu Lys Phe Leu Arg Arg Leu Arg Thr Ser Asp 
            420                 425                 430         


Asn Gly Arg Ile Pro Phe Gln Leu Asn Leu Glu Glu Met Thr Ala Ile 
        435                 440                 445             


Ile Ile Asn Gln Gly Lys Tyr Tyr Pro Phe Leu Leu Glu Gln Gln Glu 
    450                 455                 460                 


Lys Leu Glu Ser Leu Val Arg Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
465                 470                 475                 480 


Leu Thr Arg Ile Asn Ala Arg Leu Asp Ser Lys Gly Asn Ala Cys Phe 
                485                 490                 495     


Ala Trp Ser Lys Arg Lys Asp Gly Met Asp Ser Ala Ser Ile Lys Pro 
            500                 505                 510         


Trp Asn Trp Asp Glu Val Ile Asp Lys His Ala Ser Ala Gln Ala Phe 
        515                 520                 525             


Ile Glu Arg Met Thr Gly Thr Cys Thr Tyr Leu Arg Gly Glu Pro Val 
    530                 535                 540                 


Leu Pro Arg Cys Ser Leu Leu Tyr Glu Glu Tyr Cys Val Leu Asn Glu 
545                 550                 555                 560 


Leu Asn Gly Ala Arg Trp Thr Gln Asp Gly Asp Lys Phe Ile Arg Phe 
                565                 570                 575     


Asp Tyr Lys Asp Arg Ser Asp Ile Ile Glu Glu Leu Phe Lys Lys Arg 
            580                 585                 590         


Arg Gly Arg Ile Gln Tyr Ala Ala Val Ala Asp Trp Met Lys Gln Glu 
        595                 600                 605             


Arg Ser His Ala Asn Val His Val Ser Gly Gly Gln Gly Glu Asn Ala 
    610                 615                 620                 


Phe Glu Ser Arg Leu Ser Ser Tyr His Phe Phe Cys Asn Asp Val Phe 
625                 630                 635                 640 


Gly Val Asp Glu Leu Pro Gly Ser Tyr Val Asp Met Val Glu Glu Ile 
                645                 650                 655     


Ile Leu Trp Ser Thr Leu Phe Glu Asp Arg Ser Ile Leu Arg Glu Glu 
            660                 665                 670         


Ile Gln Arg Lys Tyr Gly Asp Val Leu Asn Glu Glu Gln Ile Lys Thr 
        675                 680                 685             


Ile Cys Lys Lys Arg Phe Ser Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    690                 695                 700                 


Leu Cys Ser Leu Lys Ala Gln Thr Asp Asn Gly Pro Lys Ser Ile Met 
705                 710                 715                 720 


Asp Ile Leu Gln Glu Gly Asp Gln Asn Asn Gly Arg Val Gly Arg Ala 
                725                 730                 735     


Met Val Phe Gln Glu Ile Leu His Asp Glu Gln Leu Gly Phe Glu Gln 
            740                 745                 750         


Lys Ile Glu Glu Glu Asn Thr Gln Ser Met Leu Glu Gly Glu Asn Leu 
        755                 760                 765             


Leu Ile Glu Asp Leu Pro Gly Ser Pro Ala Ile Arg Arg Ser Ile Asn 
    770                 775                 780                 


Gln Ala Val Arg Ile Val Asp Glu Ile Val Gly Ile Ala Gly His Ala 
785                 790                 795                 800 


Pro Asp Asn Ile Phe Ile Glu Val Thr Arg Glu Asp Asp Thr Lys Lys 
                805                 810                 815     


Lys Gly Lys Arg Thr Thr Thr Arg Tyr Ser Asn Ile Gln Lys Ala Leu 
            820                 825                 830         


Glu Ala Leu Lys Glu Glu Gly Ala Glu Ala Leu Arg Glu Leu Lys Thr 
        835                 840                 845             


Tyr Lys His Asn Glu Leu Asp Lys Arg Leu Ser Leu Tyr Phe Met Gln 
    850                 855                 860                 


Asn Gly Lys Ser Leu Tyr Ser Gly Ile Pro Leu Asp Ile Arg Arg Leu 
865                 870                 875                 880 


Ser Glu Tyr Gln Ile Asp His Ile Ile Pro Gln Ser Tyr Ile Lys Asp 
                885                 890                 895     


Asp Ser Tyr Glu Asn Met Ala Leu Val Leu Pro Gly Glu Asn Gln Ser 
            900                 905                 910         


Lys Ala Asp Asn Leu Leu Ile Ser Gln Asp Ile Arg Ile Lys Met Lys 
        915                 920                 925             


Ala Thr Trp Thr Ala Leu His Lys Ala Gly Leu Met Gly Asp Lys Lys 
    930                 935                 940                 


Tyr Asn Asn Leu Met Asn Ser Ser Ile Ser Asp Ala Lys Met Lys Gly 
945                 950                 955                 960 


Phe Ile Asn Arg Gln Leu Val Glu Thr Ser Gln Ser Val Lys Leu Thr 
                965                 970                 975     


Gln Met Met Leu Ser Gln Lys Tyr Pro Gly Ala Lys Val Arg Pro Ile 
            980                 985                 990         


Lys Ala Ser Ile Ser Ser Gln Leu  Arg Asp Ala Cys Asp  Leu Val Lys 
        995                 1000                 1005             


Cys Arg  Glu Ala Asn Asp Tyr  His His Ala His Asp  Ala Tyr Leu 
    1010                 1015                 1020             


Ala Cys  Gln Val Gly Arg Phe  Val Leu Lys Arg His  Ser Ser Met 
    1025                 1030                 1035             


Phe Asp  Asn Pro Ile Gly Met  Thr Lys Val Ile Arg  Asp Phe Val 
    1040                 1045                 1050             


Lys Arg  Gln Gly Gln Glu Phe  Lys Arg Asn Gly Lys  Leu Pro Ala 
    1055                 1060                 1065             


Tyr Ala  Ser Arg Ser Gly Phe  Ile Val Gln Ser Phe  Met Arg Ser 
    1070                 1075                 1080             


Gly Phe  Asp Ala Glu Thr Gly  Glu Leu Leu Arg Asp  Asp Trp Asn 
    1085                 1090                 1095             


Ala Pro  Phe Glu Ile Ala Arg  Ile Lys Arg Cys Leu  Asn Tyr Arg 
    1100                 1105                 1110             


Asp Cys  Tyr Ile Ser Arg Met  Pro Met Glu Asp Ser  Gly Ala Phe 
    1115                 1120                 1125             


Trp Asp  Ala Thr Ile Tyr Ser  Pro Lys Ala Gly Lys  Lys Gly Ala 
    1130                 1135                 1140             


Leu Pro  Val Lys Gln Gly Leu  Pro Val Glu Lys Tyr  Gly Ser Tyr 
    1145                 1150                 1155             


Ser Arg  Glu Gln Phe Ala Tyr  Phe Phe Val Tyr Lys  Ala Tyr Asn 
    1160                 1165                 1170             


Pro Lys  Lys Lys Ala Tyr Arg  Leu Glu Phe Glu Ala  Val Pro Val 
    1175                 1180                 1185             


Arg Val  Ala Ser Ala Val Glu  Thr Arg Glu Asn Ala  Leu Glu Glu 
    1190                 1195                 1200             


Tyr Ala  Lys Ser Val Ala Lys  Gln Ala Gly Leu Glu  Phe Val Glu 
    1205                 1210                 1215             


Val Ala  Arg Pro Lys Val Tyr  Lys Tyr Gln Leu Ile  Glu Leu Gly 
    1220                 1225                 1230             


Glu Asp  Arg Leu Tyr Ile Thr  Gly Lys Arg Glu Val  Arg Asn Ala 
    1235                 1240                 1245             


Ser Gln  Leu Ala Phe Ser Leu  Asp Glu Ile Asp Leu  Leu Lys Arg 
    1250                 1255                 1260             


Leu Ala  Glu Gly Glu Glu Thr  Ser Ser Glu Glu Arg  Glu Arg Leu 
    1265                 1270                 1275             


Phe Asp  Val Leu Ile Glu Lys  Tyr Ala Arg Tyr Ala  Pro Arg Leu 
    1280                 1285                 1290             


Ala Arg  Gln Leu Ser Val Asp  Ser Met Ser Ala Thr  Phe Glu Thr 
    1295                 1300                 1305             


Leu Asn  Ala Glu Glu Gln Leu  Gly Ile Leu Leu Ser  Leu Val Glu 
    1310                 1315                 1320             


Ile Ala  Asn Gly Lys Arg Asn  Met Ile Asp Leu Ser  Ser Ala Gly 
    1325                 1330                 1335             


Gly Ser  Lys Asn Ala Gly Cys  Met Asn Pro Thr Phe  Ser Ser Glu 
    1340                 1345                 1350             


Leu Ser  Ser Pro Gly Ser Asn  Phe Thr Phe Ile Asp  Gln Ser Val 
    1355                 1360                 1365             


Thr Gly  Met Phe Glu Arg Arg  Gln Arg Leu Glu Leu  
    1370                 1375                 1380 


<210> 186
<211> 1195
<212> PRT
<213> Elusimicrobium minutum

<400> 186
Met Gln Lys Asn Ile Asn Thr Lys Gln Asn His Ile Tyr Ile Lys Gln 
1               5                   10                  15      


Ala Gln Lys Ile Lys Glu Lys Leu Gly Asp Lys Pro Tyr Arg Ile Gly 
            20                  25                  30          


Leu Asp Leu Gly Val Gly Ser Ile Gly Phe Ala Ile Val Ser Met Glu 
        35                  40                  45              


Glu Asn Asp Gly Asn Val Leu Leu Pro Lys Glu Ile Ile Met Val Gly 
    50                  55                  60                  


Ser Arg Ile Phe Lys Ala Ser Ala Gly Ala Ala Asp Arg Lys Leu Ser 
65                  70                  75                  80  


Arg Gly Gln Arg Asn Asn His Arg His Thr Arg Glu Arg Met Arg Tyr 
                85                  90                  95      


Leu Trp Lys Val Leu Ala Glu Gln Lys Leu Ala Leu Pro Val Pro Ala 
            100                 105                 110         


Asp Leu Asp Arg Lys Glu Asn Ser Ser Glu Gly Glu Thr Ser Ala Lys 
        115                 120                 125             


Arg Phe Leu Gly Asp Val Leu Gln Lys Asp Ile Tyr Glu Leu Arg Val 
    130                 135                 140                 


Lys Ser Leu Asp Glu Arg Leu Ser Leu Gln Glu Leu Gly Tyr Val Leu 
145                 150                 155                 160 


Tyr His Ile Ala Gly His Arg Gly Ser Ser Ala Ile Arg Thr Phe Glu 
                165                 170                 175     


Asn Asp Ser Glu Glu Ala Gln Lys Glu Asn Thr Glu Asn Lys Lys Ile 
            180                 185                 190         


Ala Gly Asn Ile Lys Arg Leu Met Ala Lys Lys Asn Tyr Arg Thr Tyr 
        195                 200                 205             


Gly Glu Tyr Leu Tyr Lys Glu Phe Phe Glu Asn Lys Glu Lys His Lys 
    210                 215                 220                 


Arg Glu Lys Ile Ser Asn Ala Ala Asn Asn His Lys Phe Ser Pro Thr 
225                 230                 235                 240 


Arg Asp Leu Val Ile Lys Glu Ala Glu Ala Ile Leu Lys Lys Gln Ala 
                245                 250                 255     


Gly Lys Asp Gly Phe His Lys Glu Leu Thr Glu Glu Tyr Ile Glu Lys 
            260                 265                 270         


Leu Thr Lys Ala Ile Gly Tyr Glu Ser Glu Lys Leu Ile Pro Glu Ser 
        275                 280                 285             


Gly Phe Cys Pro Tyr Leu Lys Asp Glu Lys Arg Leu Pro Ala Ser His 
    290                 295                 300                 


Lys Leu Asn Glu Glu Arg Arg Leu Trp Glu Thr Leu Asn Asn Ala Arg 
305                 310                 315                 320 


Tyr Ser Asp Pro Ile Val Asp Ile Val Thr Gly Glu Ile Thr Gly Tyr 
                325                 330                 335     


Tyr Glu Lys Gln Phe Thr Lys Glu Gln Lys Gln Lys Leu Phe Asp Tyr 
            340                 345                 350         


Leu Leu Thr Gly Ser Glu Leu Thr Pro Ala Gln Thr Lys Lys Leu Leu 
        355                 360                 365             


Gly Leu Lys Asn Thr Asn Phe Glu Asp Ile Ile Leu Gln Gly Arg Asp 
    370                 375                 380                 


Lys Lys Ala Gln Lys Ile Lys Gly Tyr Lys Leu Ile Lys Leu Glu Ser 
385                 390                 395                 400 


Met Pro Phe Trp Ala Arg Leu Ser Glu Ala Gln Gln Asp Ser Phe Leu 
                405                 410                 415     


Tyr Asp Trp Asn Ser Cys Pro Asp Glu Lys Leu Leu Thr Glu Lys Leu 
            420                 425                 430         


Ser Asn Glu Tyr His Leu Thr Glu Glu Glu Ile Asp Asn Ala Phe Asn 
        435                 440                 445             


Glu Ile Val Leu Ser Ser Ser Tyr Ala Pro Leu Gly Lys Ser Ala Met 
    450                 455                 460                 


Leu Ile Ile Leu Glu Lys Ile Lys Asn Asp Leu Ser Tyr Thr Glu Ala 
465                 470                 475                 480 


Val Glu Glu Ala Leu Lys Glu Gly Lys Leu Thr Lys Glu Lys Gln Ala 
                485                 490                 495     


Ile Lys Asp Arg Leu Pro Tyr Tyr Gly Ala Val Leu Gln Glu Ser Thr 
            500                 505                 510         


Gln Lys Ile Ile Ala Lys Gly Phe Ser Pro Gln Phe Lys Asp Lys Gly 
        515                 520                 525             


Tyr Lys Thr Pro His Thr Asn Lys Tyr Glu Leu Glu Tyr Gly Arg Ile 
    530                 535                 540                 


Ala Asn Pro Val Val His Gln Thr Leu Asn Glu Leu Arg Lys Leu Val 
545                 550                 555                 560 


Asn Glu Ile Ile Asp Ile Leu Gly Lys Lys Pro Cys Glu Ile Gly Leu 
                565                 570                 575     


Glu Thr Ala Arg Glu Leu Lys Lys Ser Ala Glu Asp Arg Ser Lys Leu 
            580                 585                 590         


Ser Arg Glu Gln Asn Asp Asn Glu Ser Asn Arg Asn Arg Ile Tyr Glu 
        595                 600                 605             


Ile Tyr Ile Arg Pro Gln Gln Gln Val Ile Ile Thr Arg Arg Glu Asn 
    610                 615                 620                 


Pro Arg Asn Tyr Ile Leu Lys Phe Glu Leu Leu Glu Glu Gln Lys Ser 
625                 630                 635                 640 


Gln Cys Pro Phe Cys Gly Gly Gln Ile Ser Pro Asn Asp Ile Ile Asn 
                645                 650                 655     


Asn Gln Ala Asp Ile Glu His Leu Phe Pro Ile Ala Glu Ser Glu Asp 
            660                 665                 670         


Asn Gly Arg Asn Asn Leu Val Ile Ser His Ser Ala Cys Asn Ala Asp 
        675                 680                 685             


Lys Ala Lys Arg Ser Pro Trp Ala Ala Phe Ala Ser Ala Ala Lys Asp 
    690                 695                 700                 


Ser Lys Tyr Asp Tyr Asn Arg Ile Leu Ser Asn Val Lys Glu Asn Ile 
705                 710                 715                 720 


Pro His Lys Ala Trp Arg Phe Asn Gln Gly Ala Phe Glu Lys Phe Ile 
                725                 730                 735     


Glu Asn Lys Pro Met Ala Ala Arg Phe Lys Thr Asp Asn Ser Tyr Ile 
            740                 745                 750         


Ser Lys Val Ala His Lys Tyr Leu Ala Cys Leu Phe Glu Lys Pro Asn 
        755                 760                 765             


Ile Ile Cys Val Lys Gly Ser Leu Thr Ala Gln Leu Arg Met Ala Trp 
    770                 775                 780                 


Gly Leu Gln Gly Leu Met Ile Pro Phe Ala Lys Gln Leu Ile Thr Glu 
785                 790                 795                 800 


Lys Glu Ser Glu Ser Phe Asn Lys Asp Val Asn Ser Asn Lys Lys Ile 
                805                 810                 815     


Arg Leu Asp Asn Arg His His Ala Leu Asp Ala Ile Val Ile Ala Tyr 
            820                 825                 830         


Ala Ser Arg Gly Tyr Gly Asn Leu Leu Asn Lys Met Ala Gly Lys Asp 
        835                 840                 845             


Tyr Lys Ile Asn Tyr Ser Glu Arg Asn Trp Leu Ser Lys Ile Leu Leu 
    850                 855                 860                 


Pro Pro Asn Asn Ile Val Trp Glu Asn Ile Asp Ala Asp Leu Glu Ser 
865                 870                 875                 880 


Phe Glu Ser Ser Val Lys Thr Ala Leu Lys Asn Ala Phe Ile Ser Val 
                885                 890                 895     


Lys His Asp His Ser Asp Asn Gly Glu Leu Val Lys Gly Thr Met Tyr 
            900                 905                 910         


Lys Ile Phe Tyr Ser Glu Arg Gly Tyr Thr Leu Thr Thr Tyr Lys Lys 
        915                 920                 925             


Leu Ser Ala Leu Lys Leu Thr Asp Pro Gln Lys Lys Lys Thr Pro Lys 
    930                 935                 940                 


Asp Phe Leu Glu Thr Ala Leu Leu Lys Phe Lys Gly Arg Glu Ser Glu 
945                 950                 955                 960 


Met Lys Asn Glu Lys Ile Lys Ser Ala Ile Glu Asn Asn Lys Arg Leu 
                965                 970                 975     


Phe Asp Val Ile Gln Asp Asn Leu Glu Lys Ala Lys Lys Leu Leu Glu 
            980                 985                 990         


Glu Glu Asn Glu Lys Ser Lys Ala  Glu Gly Lys Lys Glu  Lys Asn Ile 
        995                 1000                 1005             


Asn Asp  Ala Ser Ile Tyr Gln  Lys Ala Ile Ser Leu  Ser Gly Asp 
    1010                 1015                 1020             


Lys Tyr  Val Gln Leu Ser Lys  Lys Glu Pro Gly Lys  Phe Phe Ala 
    1025                 1030                 1035             


Ile Ser  Lys Pro Thr Pro Thr  Thr Thr Gly Tyr Gly  Tyr Asp Thr 
    1040                 1045                 1050             


Gly Asp  Ser Leu Cys Val Asp  Leu Tyr Tyr Asp Asn  Lys Gly Lys 
    1055                 1060                 1065             


Leu Cys  Gly Glu Ile Ile Arg  Lys Ile Asp Ala Gln  Gln Lys Asn 
    1070                 1075                 1080             


Pro Leu  Lys Tyr Lys Glu Gln  Gly Phe Thr Leu Phe  Glu Arg Ile 
    1085                 1090                 1095             


Tyr Gly  Gly Asp Ile Leu Glu  Val Asp Phe Asp Ile  His Ser Asp 
    1100                 1105                 1110             


Lys Asn  Ser Phe Arg Asn Asn  Thr Gly Ser Ala Pro  Glu Asn Arg 
    1115                 1120                 1125             


Val Phe  Ile Lys Val Gly Thr  Phe Thr Glu Ile Thr  Asn Asn Asn 
    1130                 1135                 1140             


Ile Gln  Ile Trp Phe Gly Asn  Ile Ile Lys Ser Thr  Gly Gly Gln 
    1145                 1150                 1155             


Asp Asp  Ser Phe Thr Ile Asn  Ser Met Gln Gln Tyr  Asn Pro Arg 
    1160                 1165                 1170             


Lys Leu  Ile Leu Ser Ser Cys  Gly Phe Ile Lys Tyr  Arg Ser Pro 
    1175                 1180                 1185             


Ile Leu  Lys Asn Lys Glu Gly  
    1190                 1195 


<210> 187
<211> 1337
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis ATCC 29200

<400> 187
Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Asp Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Gly Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Asn Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Thr Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Ile Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210> 188
<211> 1337
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis ATCC 4200

<400> 188
Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Ala Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Ile Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Ser 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Gly Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Asn Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Ala Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Val Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210> 189
<211> 1337
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis D6

<400> 189
Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Ala Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Asn Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Thr His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Asn Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Thr Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Ile Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Gln Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210> 190
<211> 1337
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis E1Sol

<400> 190
Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Asp Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Thr Ser Val Lys Glu Gln Phe Gln Gln Phe Met Val Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Val Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Lys Val Val Lys Lys Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Ala Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Thr Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Met Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Ser  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Val Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210> 191
<211> 1150
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis Fly1

<400> 191
Met Tyr Ser Ile Gly Leu Asp Leu Gly Ile Ser Ser Val Gly Trp Ser 
1               5                   10                  15      


Val Ile Asp Glu Arg Thr Gly Asn Val Ile Asp Leu Gly Val Arg Leu 
            20                  25                  30          


Phe Ser Ala Lys Asn Ser Glu Lys Asn Leu Glu Arg Arg Thr Asn Arg 
        35                  40                  45              


Gly Gly Arg Arg Leu Ile Arg Arg Lys Thr Asn Arg Leu Lys Asp Ala 
    50                  55                  60                  


Lys Lys Ile Leu Ala Ala Val Gly Phe Tyr Glu Asp Lys Ser Leu Lys 
65                  70                  75                  80  


Asn Ser Cys Pro Tyr Gln Leu Arg Val Lys Gly Leu Thr Glu Pro Leu 
                85                  90                  95      


Ser Lys Gly Glu Ile Tyr Lys Val Thr Leu His Ile Leu Lys Lys Arg 
            100                 105                 110         


Gly Ile Ser Tyr Leu Asp Glu Asp Asp Thr Glu Ala Ala Lys Glu Ser 
        115                 120                 125             


Gln Asp Tyr Lys Glu Gln Val Arg Lys Asn Ala Gln Leu Leu Thr Lys 
    130                 135                 140                 


Tyr Thr Pro Gly Gln Ile Gln Leu Gln Arg Leu Lys Glu Asn Asn Arg 
145                 150                 155                 160 


Val Lys Thr Gly Ile Asn Ala Gln Gly Asn Tyr Gln Leu Asn Val Phe 
                165                 170                 175     


Lys Val Ser Ala Tyr Ala Asn Glu Leu Ala Thr Ile Leu Lys Thr Gln 
            180                 185                 190         


Gln Ala Phe Tyr Pro Asn Glu Leu Thr Asp Asp Trp Ile Ala Leu Phe 
        195                 200                 205             


Val Gln Pro Gly Ile Ala Glu Glu Ala Gly Leu Ile Tyr Arg Lys Arg 
    210                 215                 220                 


Pro Tyr Tyr His Gly Pro Gly Asn Glu Ala Asn Asn Ser Pro Tyr Gly 
225                 230                 235                 240 


Arg Trp Ser Asp Phe Lys Lys Thr Gly Gln Pro Ala Thr Asn Ile Phe 
                245                 250                 255     


Asp Arg Leu Ile Gly Lys Asp Phe Gln Gly Glu Leu Arg Ala Ser Gly 
            260                 265                 270         


Leu Ser Leu Ser Ala Gln Gln Tyr Asn Leu Leu Asn Asp Leu Thr Asn 
        275                 280                 285             


Leu Lys Ile Asp Gly Glu Ile Pro Leu Ser Pro Glu Gln Lys Glu Tyr 
    290                 295                 300                 


Ile Leu Ala Glu Leu Met Thr Lys Glu Phe Thr Arg Phe Gly Val Asn 
305                 310                 315                 320 


Asp Val Ala Lys Leu Leu Gly Val Lys Lys Glu Arg Leu Ser Gly Trp 
                325                 330                 335     


Arg Leu Asp Lys Lys Gly Lys Pro Glu Ile His Thr Leu Lys Gly Tyr 
            340                 345                 350         


Arg Asn Trp Arg Lys Ile Phe Ala Glu Ser Gly Ile Asp Leu Ala Thr 
        355                 360                 365             


Leu Pro Thr Glu Thr Ile Asp Cys Leu Ala Lys Val Leu Thr Leu Asn 
    370                 375                 380                 


Thr Glu His Glu Gly Ile Glu Asn Thr Leu Ala Phe Glu Leu Pro Glu 
385                 390                 395                 400 


Leu Ala Glu Ser Val Lys Leu Leu Val Leu Asp Arg Tyr Lys Glu Leu 
                405                 410                 415     


Ser Gln Ser Val Ser Thr Gln Ala Trp His Arg Phe Ser Leu Lys Thr 
            420                 425                 430         


Leu His Leu Leu Ile Pro Glu Leu Met Asn Ala Thr Ser Glu Gln Asn 
        435                 440                 445             


Thr Leu Leu Glu Gln Phe Gln Leu Lys Ser Asp Val Arg Lys Arg Tyr 
    450                 455                 460                 


Ser Glu Tyr Lys Lys Leu Pro Thr Lys Asp Val Leu Thr Glu Ile Tyr 
465                 470                 475                 480 


Asn Pro Thr Val Asn Lys Thr Val Ser Gln Ala Phe Lys Val Ile Asp 
                485                 490                 495     


Ala Leu Leu Val Lys Tyr Gly Lys Glu Gln Ile Arg Tyr Ile Thr Ile 
            500                 505                 510         


Glu Met Pro Arg Asp Asp Asn Glu Glu Asp Glu Lys Lys Arg Ile Lys 
        515                 520                 525             


Glu Leu His Ala Lys Asn Ser Gln Arg Lys Asn Asp Ser Gln Ser Tyr 
    530                 535                 540                 


Phe Met Gln Lys Ser Gly Trp Ser Gln Glu Lys Phe Gln Thr Thr Ile 
545                 550                 555                 560 


Gln Lys Asn Arg Arg Phe Leu Ala Lys Leu Leu Tyr Tyr Tyr Glu Gln 
                565                 570                 575     


Asp Gly Ile Cys Ala Tyr Thr Gly Leu Ser Ile Ser Pro Glu Leu Leu 
            580                 585                 590         


Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 
        595                 600                 605             


Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 
    610                 615                 620                 


Gln Val Lys Gly Gln Gln Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 
625                 630                 635                 640 


Phe Lys Lys Ile Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gln Lys 
                645                 650                 655     


Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 
            660                 665                 670         


Glu Thr Arg Asn Ile Phe Asp Ser Glu Gln Val Glu Lys Phe Leu Ala 
        675                 680                 685             


Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 
    690                 695                 700                 


Leu Gln Ser Phe Phe Ala Asn His Glu Thr Lys Val Arg Val Val Asn 
705                 710                 715                 720 


Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 
                725                 730                 735     


Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 
            740                 745                 750         


Ala Val Thr Pro Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 
        755                 760                 765             


Glu Glu Thr Gly Glu Lys Val Met Arg Glu Ile Asp Phe Glu Thr Gly 
    770                 775                 780                 


Glu Ile Val Asp Glu Met Ser Tyr Gln Glu Phe Lys Lys Ser Lys Lys 
785                 790                 795                 800 


Tyr Glu Arg Lys Thr Tyr Gln Val Lys Trp Pro Asn Phe Arg Glu Gln 
                805                 810                 815     


Leu Lys Pro Val Asn Leu His Pro Arg Ile Lys Phe Ser His Gln Val 
            820                 825                 830         


Asp Arg Lys Ala Asn Arg Lys Leu Ser Asp Ala Thr Ile Tyr Ser Val 
        835                 840                 845             


Arg Glu Lys Thr Glu Val Lys Thr Leu Lys Ser Gly Lys Gln Lys Ile 
    850                 855                 860                 


Thr Thr Asp Glu Tyr Thr Ile Gly Lys Ile Lys Asp Ile Tyr Thr Val 
865                 870                 875                 880 


Asp Gly Trp Glu Ala Phe Lys Lys Lys Gln Asp Lys Leu Leu Met Lys 
                885                 890                 895     


Asp Leu Asp Glu Lys Thr Tyr Glu Arg Leu Leu Ser Ile Ala Glu Thr 
            900                 905                 910         


Thr Pro Asp Phe Gln Glu Val Glu Glu Lys Asn Gly Lys Val Lys Arg 
        915                 920                 925             


Val Lys Arg Ser Pro Phe Ala Val Tyr Cys Glu Glu Asn Asp Ile Pro 
    930                 935                 940                 


Ala Ile Gln Lys Tyr Ala Lys Lys Asn Asn Gly Pro Leu Ile Arg Ser 
945                 950                 955                 960 


Leu Lys Tyr Tyr Asp Gly Lys Leu Asn Lys His Ile Asn Ile Thr Lys 
                965                 970                 975     


Asp Ser Gln Gly Arg Pro Val Glu Lys Thr Lys Asn Gly Arg Lys Val 
            980                 985                 990         


Thr Leu Gln Ser Leu Lys Pro Tyr  Arg Tyr Asp Ile Tyr  Gln Asp Leu 
        995                 1000                 1005             


Glu Thr  Lys Ala Tyr Tyr Thr  Val Gln Leu Tyr Tyr  Ser Asp Leu 
    1010                 1015                 1020             


Arg Phe  Val Glu Gly Lys Tyr  Gly Ile Thr Glu Lys  Glu Tyr Met 
    1025                 1030                 1035             


Lys Lys  Val Ala Glu Gln Thr  Lys Gly Gln Val Val  Arg Phe Cys 
    1040                 1045                 1050             


Phe Ser  Leu Gln Lys Asn Asp  Gly Leu Glu Ile Glu  Trp Lys Asp 
    1055                 1060                 1065             


Ser Gln  Arg Tyr Asp Val Arg  Phe Tyr Asn Phe Gln  Ser Ala Asn 
    1070                 1075                 1080             


Ser Ile  Asn Phe Lys Gly Leu  Glu Gln Glu Met Met  Pro Ala Glu 
    1085                 1090                 1095             


Asn Gln  Phe Lys Gln Lys Pro  Tyr Asn Asn Gly Ala  Ile Asn Leu 
    1100                 1105                 1110             


Asn Ile  Ala Lys Tyr Gly Lys  Glu Gly Lys Lys Leu  Arg Lys Phe 
    1115                 1120                 1125             


Asn Thr  Asp Ile Leu Gly Lys  Lys His Tyr Leu Tyr  Tyr Glu Lys 
    1130                 1135                 1140             


Glu Pro  Lys Asn Ile Ile Lys  
    1145                 1150 


<210> 192
<211> 1337
<212> PRT
<213> Enterococcus faecalis

<400> 192
Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Asp Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Val Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asn Gln Arg Tyr Asn Ala Asn Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Thr Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Val Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210> 193
<211> 1150
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis R508

<400> 193
Met Tyr Ser Ile Gly Leu Asp Leu Gly Ile Ser Ser Val Gly Trp Ser 
1               5                   10                  15      


Val Ile Asp Glu Arg Thr Gly Asn Val Ile Asp Leu Gly Val Arg Leu 
            20                  25                  30          


Phe Ser Ala Lys Asn Ser Glu Lys Asn Leu Glu Arg Arg Thr Asn Arg 
        35                  40                  45              


Gly Gly Arg Arg Leu Ile Arg Arg Lys Thr Asn Arg Leu Lys Asp Ala 
    50                  55                  60                  


Lys Lys Ile Leu Ala Ala Val Gly Phe Tyr Glu Asp Lys Ser Leu Lys 
65                  70                  75                  80  


Asn Ser Cys Pro Tyr Gln Leu Arg Val Lys Gly Leu Thr Glu Pro Leu 
                85                  90                  95      


Ser Lys Gly Glu Ile Tyr Lys Val Thr Leu His Ile Leu Lys Lys Arg 
            100                 105                 110         


Gly Ile Ser Tyr Leu Asp Glu Asp Asp Thr Glu Ala Ala Lys Glu Ser 
        115                 120                 125             


Gln Asp Tyr Lys Glu Gln Val Arg Lys Asn Ala Gln Leu Leu Thr Lys 
    130                 135                 140                 


Tyr Thr Pro Gly Gln Ile Gln Leu Gln Arg Leu Lys Glu Asn Asn Arg 
145                 150                 155                 160 


Val Lys Thr Gly Ile Asn Val Gln Gly Asn Tyr Gln Leu Asn Val Phe 
                165                 170                 175     


Lys Val Ser Ala Tyr Ala Asn Glu Leu Ala Thr Ile Leu Lys Thr Gln 
            180                 185                 190         


Gln Ala Phe Tyr Pro Asn Glu Leu Thr Asp Asp Trp Ile Ala Leu Phe 
        195                 200                 205             


Val Gln Pro Gly Ile Ala Glu Glu Ala Gly Leu Ile Tyr Arg Lys Arg 
    210                 215                 220                 


Pro Tyr Tyr His Gly Pro Gly Asn Glu Ala Asn Asn Ser Pro Tyr Gly 
225                 230                 235                 240 


Arg Trp Ser Asp Phe Gln Lys Thr Gly Glu Pro Ala Thr Asn Ile Phe 
                245                 250                 255     


Asp Lys Leu Ile Gly Lys Asp Phe Gln Gly Glu Leu Arg Ala Ser Gly 
            260                 265                 270         


Leu Ser Leu Ser Ala Gln Gln Tyr Asn Leu Leu Asn Asp Leu Thr Asn 
        275                 280                 285             


Leu Lys Ile Asp Gly Glu Val Pro Leu Ser Ser Glu Gln Lys Glu Tyr 
    290                 295                 300                 


Ile Leu Thr Glu Leu Met Thr Lys Glu Phe Thr Arg Phe Gly Val Asn 
305                 310                 315                 320 


Asp Val Val Lys Leu Leu Gly Val Lys Lys Glu Arg Leu Ser Gly Trp 
                325                 330                 335     


Arg Leu Asp Lys Lys Gly Lys Pro Glu Ile His Thr Leu Lys Gly Tyr 
            340                 345                 350         


Arg Asn Trp Arg Lys Ile Phe Ala Glu Ala Gly Ile Asp Leu Ala Thr 
        355                 360                 365             


Leu Pro Thr Glu Thr Ile Asp Cys Leu Ala Lys Val Leu Thr Leu Asn 
    370                 375                 380                 


Thr Glu Arg Glu Gly Ile Glu Asn Thr Leu Ala Phe Glu Leu Pro Glu 
385                 390                 395                 400 


Leu Ser Glu Ser Val Lys Leu Leu Val Leu Asp Arg Tyr Lys Glu Leu 
                405                 410                 415     


Ser Gln Ser Ile Ser Thr Gln Ser Trp His Arg Phe Ser Leu Lys Thr 
            420                 425                 430         


Leu His Leu Leu Ile Pro Glu Leu Met Asn Ala Thr Ser Glu Gln Asn 
        435                 440                 445             


Thr Leu Leu Glu Gln Phe Gln Leu Lys Ser Asp Val Arg Lys Arg Tyr 
    450                 455                 460                 


Ser Glu Tyr Lys Lys Leu Pro Thr Lys Asp Val Leu Ala Glu Ile Tyr 
465                 470                 475                 480 


Asn Pro Thr Val Asn Lys Thr Val Ser Gln Ala Phe Lys Val Ile Asp 
                485                 490                 495     


Ala Leu Leu Val Lys Tyr Gly Lys Glu Gln Ile Arg Tyr Ile Thr Ile 
            500                 505                 510         


Glu Met Pro Arg Asp Asp Asn Glu Glu Asp Glu Lys Lys Arg Ile Lys 
        515                 520                 525             


Glu Leu His Ala Lys Asn Ser Gln Arg Lys Asn Asp Ser Gln Ser Tyr 
    530                 535                 540                 


Phe Met Gln Lys Ser Gly Trp Ser Gln Glu Lys Phe Gln Thr Thr Ile 
545                 550                 555                 560 


Gln Lys Asn Arg Arg Phe Leu Ala Lys Leu Leu Tyr Tyr Tyr Glu Gln 
                565                 570                 575     


Asp Gly Ile Cys Ala Tyr Thr Gly Leu Pro Ile Ser Pro Glu Leu Leu 
            580                 585                 590         


Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 
        595                 600                 605             


Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 
    610                 615                 620                 


Gln Val Lys Gly Gln Gln Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 
625                 630                 635                 640 


Phe Lys Lys Ile Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gln Lys 
                645                 650                 655     


Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 
            660                 665                 670         


Glu Thr Arg Asn Ile Phe Asp Ser Glu Gln Val Glu Lys Phe Leu Ala 
        675                 680                 685             


Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 
    690                 695                 700                 


Leu Gln Ser Phe Phe Thr Asn Gln Glu Thr Lys Val Arg Val Val Asn 
705                 710                 715                 720 


Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 
                725                 730                 735     


Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 
            740                 745                 750         


Ala Val Thr Pro Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 
        755                 760                 765             


Glu Glu Thr Gly Glu Lys Val Met Arg Glu Ile Asp Phe Glu Thr Gly 
    770                 775                 780                 


Glu Ile Val Asn Glu Met Ser Tyr Arg Glu Phe Lys Lys Ser Lys Lys 
785                 790                 795                 800 


Tyr Glu Arg Lys Thr Tyr Gln Val Lys Trp Pro Asn Phe Arg Glu Gln 
                805                 810                 815     


Leu Lys Pro Val Asn Leu His Pro Arg Ile Lys Phe Ser His Gln Val 
            820                 825                 830         


Asp Arg Lys Ala Asn Arg Lys Leu Ser Asp Ala Thr Ile Tyr Ser Val 
        835                 840                 845             


Arg Glu Lys Thr Glu Val Lys Thr Leu Lys Ser Gly Lys Gln Lys Ile 
    850                 855                 860                 


Thr Thr Asp Glu Tyr Thr Ile Gly Lys Ile Lys Asp Ile Tyr Thr Leu 
865                 870                 875                 880 


Asp Gly Trp Glu Ala Phe Lys Lys Lys Gln Asp Lys Leu Leu Met Lys 
                885                 890                 895     


Asp Leu Asp Glu Lys Thr Tyr Glu Arg Leu Leu Ser Ile Ala Glu Thr 
            900                 905                 910         


Thr Pro Asp Phe Gln Glu Val Glu Glu Lys Asn Gly Lys Val Lys Arg 
        915                 920                 925             


Val Lys Arg Ser Pro Phe Ala Val Tyr Cys Glu Glu Asn Asp Ile Pro 
    930                 935                 940                 


Ala Ile Gln Lys Tyr Ala Lys Lys Asn Asn Gly Pro Leu Ile Arg Ser 
945                 950                 955                 960 


Leu Lys Tyr Tyr Asp Gly Lys Leu Asn Lys His Ile Asn Ile Thr Lys 
                965                 970                 975     


Asp Ser Gln Gly Arg Pro Val Glu Lys Thr Lys Asn Gly Arg Lys Val 
            980                 985                 990         


Thr Leu Gln Ser Leu Lys Pro Tyr  Arg Tyr Asp Ile Tyr  Gln Asp Leu 
        995                 1000                 1005             


Glu Thr  Lys Ala Tyr Tyr Thr  Val Gln Leu Tyr Tyr  Ser Asp Leu 
    1010                 1015                 1020             


Arg Phe  Val Glu Gly Lys Tyr  Gly Ile Thr Glu Lys  Glu Tyr Met 
    1025                 1030                 1035             


Lys Lys  Val Ala Glu Gln Thr  Lys Gly Gln Val Val  Arg Phe Cys 
    1040                 1045                 1050             


Phe Ser  Leu Gln Lys Asn Asp  Gly Leu Glu Ile Glu  Trp Lys Asp 
    1055                 1060                 1065             


Ser Gln  Arg Tyr Asp Val Arg  Phe Tyr Asn Phe Gln  Ser Ala Asn 
    1070                 1075                 1080             


Ser Ile  Asn Phe Lys Gly Leu  Glu Gln Glu Ile Met  Pro Ala Glu 
    1085                 1090                 1095             


Asn Gln  Phe Lys Gln Lys Pro  Tyr Asn Asn Gly Ala  Ile Asn Leu 
    1100                 1105                 1110             


Asn Ile  Ala Lys Tyr Gly Lys  Glu Gly Lys Lys Leu  Arg Lys Phe 
    1115                 1120                 1125             


Asn Thr  Asp Ile Leu Gly Lys  Lys His Tyr Leu Phe  Tyr Glu Lys 
    1130                 1135                 1140             


Glu Pro  Lys Asn Ile Ile Lys  
    1145                 1150 


<210> 194
<211> 1150
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis T11

<400> 194
Met Tyr Ser Ile Gly Leu Asp Leu Gly Ile Ser Ser Val Gly Trp Ser 
1               5                   10                  15      


Val Ile Asp Glu Arg Thr Gly Asn Val Ile Asp Leu Gly Val Arg Leu 
            20                  25                  30          


Phe Ser Ala Lys Asn Ser Glu Lys Asn Leu Glu Arg Arg Thr Asn Arg 
        35                  40                  45              


Gly Gly Arg Arg Leu Ile Arg Arg Lys Thr Asn Arg Leu Lys Asp Ala 
    50                  55                  60                  


Lys Lys Ile Leu Ala Ala Val Gly Phe Tyr Glu Asp Lys Ser Leu Lys 
65                  70                  75                  80  


Asn Ser Cys Pro Tyr Gln Leu Arg Val Lys Gly Leu Thr Glu Pro Leu 
                85                  90                  95      


Ser Lys Gly Glu Ile Tyr Lys Val Thr Leu His Ile Leu Lys Lys Arg 
            100                 105                 110         


Gly Ile Ser Tyr Leu Asp Glu Asp Asp Thr Glu Ala Ala Lys Glu Ser 
        115                 120                 125             


Gln Asp Tyr Lys Glu Gln Val Arg Glu Asn Ala Gln Leu Leu Thr Lys 
    130                 135                 140                 


Tyr Thr Pro Gly Gln Ile Gln Leu Gln Arg Leu Lys Glu Asn Asn Arg 
145                 150                 155                 160 


Val Lys Thr Gly Ile Asn Ala Gln Gly Asn Tyr Gln Leu Asn Val Phe 
                165                 170                 175     


Lys Val Ser Ala Tyr Ala Asn Glu Leu Ala Thr Ile Leu Lys Thr Gln 
            180                 185                 190         


Gln Ala Phe Tyr Pro Asn Glu Leu Thr Asp Asp Trp Ile Ala Leu Phe 
        195                 200                 205             


Val Gln Pro Gly Ile Ala Glu Glu Ala Gly Leu Ile Tyr Arg Lys Arg 
    210                 215                 220                 


Pro Tyr Tyr His Gly Pro Gly Asn Glu Ala Asn Asn Ser Pro Tyr Gly 
225                 230                 235                 240 


Arg Trp Ser Asp Phe Lys Lys Thr Gly Gln Pro Ala Thr Asn Ile Phe 
                245                 250                 255     


Asp Lys Leu Ile Gly Lys Asp Phe Gln Gly Glu Leu Arg Ala Ser Gly 
            260                 265                 270         


Leu Ser Leu Ser Ala Gln Gln Tyr Asn Leu Leu Asn Asp Leu Thr Asn 
        275                 280                 285             


Leu Lys Ile Asp Gly Glu Ile Pro Leu Ser Pro Glu Gln Lys Glu Tyr 
    290                 295                 300                 


Ile Leu Ala Glu Leu Met Thr Lys Glu Phe Thr Arg Phe Gly Val Asn 
305                 310                 315                 320 


Asp Val Val Lys Leu Leu Gly Val Lys Lys Glu Arg Leu Ser Gly Trp 
                325                 330                 335     


Arg Leu Asp Lys Lys Gly Lys Pro Glu Ile His Thr Leu Lys Gly Tyr 
            340                 345                 350         


Arg Asn Trp Arg Lys Ile Phe Ala Glu Ser Gly Ile Asp Leu Ala Met 
        355                 360                 365             


Leu Pro Thr Glu Thr Ile Asp Cys Leu Ala Lys Ile Leu Thr Leu Asn 
    370                 375                 380                 


Thr Glu Arg Glu Gly Ile Glu Asn Thr Leu Ala Phe Glu Leu Pro Glu 
385                 390                 395                 400 


Leu Ala Glu Ser Val Lys Leu Leu Val Leu Asp Arg Tyr Lys Glu Leu 
                405                 410                 415     


Ser Gln Ser Val Ser Thr Gln Ala Trp His Arg Phe Ser Leu Lys Thr 
            420                 425                 430         


Leu His Leu Leu Ile Pro Glu Leu Met Asn Ala Thr Ser Glu Gln Asn 
        435                 440                 445             


Thr Leu Leu Glu Gln Phe Gln Leu Lys Ser Asp Val Arg Lys Arg Tyr 
    450                 455                 460                 


Ser Glu Tyr Lys Lys Leu Pro Thr Lys Asp Val Leu Thr Glu Ile Tyr 
465                 470                 475                 480 


Asn Pro Thr Val Asn Lys Thr Val Ser Gln Ala Phe Lys Val Ile Asp 
                485                 490                 495     


Ala Leu Leu Val Lys Tyr Gly Lys Glu Gln Ile Arg Tyr Ile Thr Ile 
            500                 505                 510         


Glu Met Pro Arg Asp Asp Asn Glu Glu Asp Glu Lys Lys Arg Ile Lys 
        515                 520                 525             


Glu Leu His Ala Lys Asn Ser Gln Arg Lys Asn Asp Ser Gln Ser Tyr 
    530                 535                 540                 


Phe Met Gln Lys Ser Gly Trp Ser Gln Glu Lys Phe Gln Thr Thr Ile 
545                 550                 555                 560 


Gln Lys Asn Arg Arg Phe Leu Ala Lys Leu Leu Tyr Tyr Tyr Glu Gln 
                565                 570                 575     


Asp Gly Ile Cys Ala Tyr Thr Gly Leu Ser Ile Ser Pro Glu Leu Leu 
            580                 585                 590         


Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 
        595                 600                 605             


Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 
    610                 615                 620                 


Gln Val Lys Gly Gln Gln Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 
625                 630                 635                 640 


Phe Lys Lys Ile Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gln Lys 
                645                 650                 655     


Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 
            660                 665                 670         


Glu Thr Arg Asn Ile Phe Asp Ser Glu Gln Val Glu Lys Phe Leu Ala 
        675                 680                 685             


Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 
    690                 695                 700                 


Leu Gln Ser Phe Phe Ala Asn Gln Glu Thr Lys Val Arg Val Val Asn 
705                 710                 715                 720 


Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 
                725                 730                 735     


Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 
            740                 745                 750         


Ala Val Thr Pro Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 
        755                 760                 765             


Glu Glu Thr Gly Glu Lys Val Met Arg Glu Ile Asp Phe Glu Thr Gly 
    770                 775                 780                 


Glu Ile Val Asp Glu Met Ser Tyr Arg Glu Phe Lys Lys Ser Lys Lys 
785                 790                 795                 800 


Tyr Glu Arg Lys Thr Tyr Gln Val Lys Trp Pro Asn Phe Arg Glu Gln 
                805                 810                 815     


Leu Lys Pro Val Asn Leu His Pro Arg Ile Lys Phe Ser His Gln Val 
            820                 825                 830         


Asp Arg Lys Ala Asn Arg Lys Leu Ser Asp Ala Thr Ile Tyr Ser Val 
        835                 840                 845             


Arg Glu Lys Thr Glu Val Lys Thr Leu Lys Ser Gly Lys Gln Lys Ile 
    850                 855                 860                 


Thr Thr Asp Glu Tyr Thr Ile Gly Lys Ile Lys Asp Ile Tyr Thr Val 
865                 870                 875                 880 


Asp Gly Trp Glu Ala Phe Lys Lys Lys Gln Asp Lys Leu Leu Met Lys 
                885                 890                 895     


Asp Leu Asp Glu Lys Thr Tyr Glu Arg Leu Leu Ser Ile Ala Glu Thr 
            900                 905                 910         


Thr Pro Asp Phe Gln Glu Val Glu Glu Lys Asn Gly Lys Val Lys Arg 
        915                 920                 925             


Val Lys Arg Ser Pro Phe Ala Val Tyr Cys Glu Glu Asn Asp Ile Pro 
    930                 935                 940                 


Ala Ile Arg Lys Tyr Ala Lys Lys Asn Asn Gly Pro Leu Ile Arg Ser 
945                 950                 955                 960 


Leu Lys Tyr Tyr Asp Gly Lys Leu Asn Lys His Ile Asn Ile Thr Lys 
                965                 970                 975     


Asp Ser Gln Gly Arg Pro Val Glu Lys Thr Lys Asn Gly Arg Lys Val 
            980                 985                 990         


Thr Leu Gln Ser Leu Lys Pro Tyr  Arg Tyr Asp Ile Tyr  Gln Asp Leu 
        995                 1000                 1005             


Glu Thr  Lys Ala Tyr Tyr Thr  Val Gln Leu Tyr Tyr  Ser Asp Leu 
    1010                 1015                 1020             


Arg Phe  Val Glu Gly Lys Tyr  Gly Ile Thr Glu Lys  Glu Tyr Met 
    1025                 1030                 1035             


Lys Lys  Val Ala Glu Gln Thr  Lys Gly Gln Val Val  Arg Phe Cys 
    1040                 1045                 1050             


Phe Ser  Leu Gln Lys Asn Asp  Gly Leu Glu Ile Glu  Trp Lys Asp 
    1055                 1060                 1065             


Ser Gln  Arg Tyr Asp Val Arg  Phe Tyr Asn Phe Gln  Ser Ala Asn 
    1070                 1075                 1080             


Ser Ile  Asn Phe Lys Gly Leu  Glu Gln Glu Met Met  Pro Ala Glu 
    1085                 1090                 1095             


Asn Gln  Phe Lys Gln Lys Pro  Tyr Asn Asn Gly Ala  Ile Asn Leu 
    1100                 1105                 1110             


Asn Ile  Ala Lys Tyr Gly Lys  Glu Gly Lys Lys Leu  Arg Lys Phe 
    1115                 1120                 1125             


Asn Thr  Asp Ile Leu Gly Lys  Lys His Tyr Leu Tyr  Tyr Glu Lys 
    1130                 1135                 1140             


Glu Pro  Lys Asn Ile Ile Lys  
    1145                 1150 


<210> 195
<211> 1150
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis TX0012

<400> 195
Met Tyr Ser Ile Gly Leu Asp Leu Gly Ile Ser Ser Val Gly Trp Ser 
1               5                   10                  15      


Val Ile Asp Glu Arg Thr Gly Asn Val Ile Asp Leu Gly Val Arg Leu 
            20                  25                  30          


Phe Ser Ala Lys Asn Ser Glu Lys Asn Leu Glu Arg Arg Thr Asn Arg 
        35                  40                  45              


Gly Gly Arg Arg Leu Ile Arg Arg Lys Thr Asn Arg Leu Lys Asp Ala 
    50                  55                  60                  


Lys Lys Ile Leu Ala Ala Val Gly Phe Tyr Glu Asp Lys Ser Leu Lys 
65                  70                  75                  80  


Asn Ser Cys Pro Tyr Gln Leu Arg Val Lys Gly Leu Thr Glu Pro Leu 
                85                  90                  95      


Ser Arg Gly Glu Ile Tyr Lys Val Thr Leu His Ile Leu Lys Lys Arg 
            100                 105                 110         


Gly Ile Ser Tyr Leu Asp Glu Val Asp Thr Glu Ala Ala Lys Glu Ser 
        115                 120                 125             


Gln Asp Tyr Lys Glu Gln Val Arg Lys Asn Ala Gln Leu Leu Thr Lys 
    130                 135                 140                 


Tyr Thr Pro Gly Gln Ile Gln Leu Gln Arg Leu Lys Glu Asn Asn Arg 
145                 150                 155                 160 


Val Lys Thr Gly Ile Asn Ala Gln Gly Asn Tyr Gln Leu Asn Val Phe 
                165                 170                 175     


Lys Val Ser Ala Tyr Ala Asn Glu Leu Ala Thr Ile Leu Lys Thr Gln 
            180                 185                 190         


Gln Ala Phe Tyr Pro Asn Glu Leu Thr Asp Asp Trp Ile Ala Leu Phe 
        195                 200                 205             


Val Gln Pro Gly Ile Ala Glu Glu Ala Gly Leu Ile Tyr Arg Lys Arg 
    210                 215                 220                 


Pro Tyr Tyr His Gly Pro Gly Asn Glu Ala Asn Asn Ser Pro Tyr Gly 
225                 230                 235                 240 


Arg Trp Ser Asp Phe Gln Lys Thr Gly Glu Pro Ala Thr Asn Ile Phe 
                245                 250                 255     


Asp Lys Leu Ile Gly Lys Asp Phe Gln Gly Glu Leu Arg Ala Ser Gly 
            260                 265                 270         


Leu Ser Leu Ser Ala Gln Gln Tyr Asn Leu Leu Asn Asp Leu Thr Asn 
        275                 280                 285             


Leu Lys Ile Asp Gly Glu Val Pro Leu Ser Ser Glu Gln Lys Glu Tyr 
    290                 295                 300                 


Ile Leu Thr Glu Leu Met Thr Lys Glu Phe Thr Arg Phe Gly Val Asn 
305                 310                 315                 320 


Asp Val Val Lys Leu Leu Gly Val Lys Lys Glu Arg Leu Ser Gly Trp 
                325                 330                 335     


Arg Leu Asp Lys Lys Gly Lys Pro Glu Ile His Thr Leu Lys Gly Tyr 
            340                 345                 350         


Arg Asn Trp Arg Lys Ile Phe Ala Glu Ala Gly Ile Asp Leu Ala Thr 
        355                 360                 365             


Leu Pro Thr Glu Thr Ile Asp Cys Leu Ala Lys Val Leu Thr Leu Asn 
    370                 375                 380                 


Thr Glu Arg Glu Gly Ile Glu Asn Thr Leu Ala Phe Glu Leu Pro Glu 
385                 390                 395                 400 


Leu Ser Glu Ser Val Lys Leu Leu Val Leu Asp Arg Tyr Lys Glu Leu 
                405                 410                 415     


Ser Gln Ser Ile Ser Thr Gln Ser Trp His Arg Phe Ser Leu Lys Thr 
            420                 425                 430         


Leu His Leu Leu Ile Pro Glu Leu Met Asn Ala Thr Ser Glu Gln Asn 
        435                 440                 445             


Thr Leu Leu Glu Gln Phe Gln Leu Lys Ser Asp Val Arg Lys Arg Tyr 
    450                 455                 460                 


Ser Glu Tyr Lys Lys Leu Pro Thr Lys Asp Val Leu Ala Glu Ile Tyr 
465                 470                 475                 480 


Asn Pro Thr Val Asn Lys Thr Val Ser Gln Ala Phe Lys Val Ile Asp 
                485                 490                 495     


Ala Leu Leu Val Lys Tyr Gly Lys Glu Gln Ile Arg Tyr Ile Thr Ile 
            500                 505                 510         


Glu Met Pro Arg Asp Asp Asn Glu Glu Asp Glu Lys Lys Arg Ile Lys 
        515                 520                 525             


Glu Leu His Ala Lys Asn Ser Gln Arg Lys Asn Asp Ser Gln Ser Tyr 
    530                 535                 540                 


Phe Met Gln Lys Ser Gly Trp Ser Gln Glu Lys Phe Gln Thr Thr Ile 
545                 550                 555                 560 


Gln Lys Asn Arg Arg Phe Leu Ala Lys Leu Leu Tyr Tyr Tyr Glu Gln 
                565                 570                 575     


Asp Gly Ile Cys Ala Tyr Thr Gly Leu Pro Ile Ser Pro Glu Leu Leu 
            580                 585                 590         


Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 
        595                 600                 605             


Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 
    610                 615                 620                 


Gln Val Lys Gly Gln Gln Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 
625                 630                 635                 640 


Phe Lys Lys Ile Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gln Lys 
                645                 650                 655     


Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 
            660                 665                 670         


Glu Thr Arg Asn Ile Phe Asp Ser Glu Gln Val Glu Lys Phe Leu Ala 
        675                 680                 685             


Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 
    690                 695                 700                 


Leu Gln Ser Phe Phe Thr Asn Gln Glu Thr Lys Val Arg Val Val Asn 
705                 710                 715                 720 


Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 
                725                 730                 735     


Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 
            740                 745                 750         


Ala Val Thr Ser Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 
        755                 760                 765             


Glu Glu Thr Gly Glu Lys Val Met Arg Glu Ile Asp Phe Glu Thr Gly 
    770                 775                 780                 


Glu Ile Val Asn Glu Met Ser Tyr Trp Glu Phe Lys Lys Ser Lys Lys 
785                 790                 795                 800 


Tyr Glu Arg Lys Thr Tyr Gln Val Lys Trp Pro Asn Phe Arg Glu Gln 
                805                 810                 815     


Leu Lys Pro Val Asn Leu His Pro Arg Ile Lys Phe Ser His Gln Val 
            820                 825                 830         


Asp Arg Lys Ala Asn Arg Lys Leu Ser Asp Ala Thr Ile Tyr Ser Val 
        835                 840                 845             


Arg Glu Lys Thr Glu Val Lys Thr Leu Lys Ser Gly Lys Gln Lys Ile 
    850                 855                 860                 


Thr Thr Asp Glu Tyr Thr Ile Gly Lys Ile Lys Asp Ile Tyr Thr Leu 
865                 870                 875                 880 


Asp Gly Trp Glu Ala Phe Lys Lys Lys Gln Asp Lys Leu Leu Met Lys 
                885                 890                 895     


Asp Leu Asp Glu Lys Thr Tyr Glu Arg Leu Leu Ser Ile Ala Glu Thr 
            900                 905                 910         


Thr Pro Asp Phe Gln Glu Val Glu Glu Lys Asn Gly Lys Val Lys Arg 
        915                 920                 925             


Val Lys Arg Ser Pro Phe Ala Val Tyr Cys Glu Glu Asn Asp Ile Pro 
    930                 935                 940                 


Ala Ile Gln Lys Tyr Ala Lys Lys Asn Asn Gly Pro Leu Ile Arg Ser 
945                 950                 955                 960 


Leu Lys Tyr Tyr Asp Gly Lys Leu Asn Lys His Ile Asn Ile Thr Lys 
                965                 970                 975     


Asp Ser Gln Gly Arg Pro Val Glu Lys Thr Lys Asn Gly Arg Lys Val 
            980                 985                 990         


Thr Leu Gln Ser Leu Lys Pro Tyr  Arg Tyr Asp Ile Tyr  Gln Asp Leu 
        995                 1000                 1005             


Glu Thr  Lys Ala Tyr Tyr Thr  Val Gln Leu Tyr Tyr  Ser Asp Leu 
    1010                 1015                 1020             


Arg Phe  Val Glu Gly Lys Tyr  Gly Ile Thr Glu Lys  Glu Tyr Met 
    1025                 1030                 1035             


Lys Lys  Val Ala Glu Gln Thr  Lys Gly Gln Val Val  Arg Phe Cys 
    1040                 1045                 1050             


Phe Ser  Leu Gln Lys Asn Asp  Gly Leu Glu Ile Glu  Trp Lys Asp 
    1055                 1060                 1065             


Ser Gln  Arg Tyr Asp Val Arg  Phe Tyr Asn Phe Gln  Ser Ala Asn 
    1070                 1075                 1080             


Ser Ile  Asn Phe Lys Gly Leu  Glu Gln Glu Met Met  Pro Ala Glu 
    1085                 1090                 1095             


Asn Gln  Phe Lys Gln Lys Pro  Tyr Asn Asn Gly Ala  Ile Asn Leu 
    1100                 1105                 1110             


Asn Ile  Ala Lys Tyr Gly Lys  Glu Gly Lys Lys Leu  Arg Lys Phe 
    1115                 1120                 1125             


Asn Thr  Asp Ile Leu Gly Lys  Lys His Tyr Leu Phe  Tyr Glu Lys 
    1130                 1135                 1140             


Glu Pro  Lys Asn Ile Ile Lys  
    1145                 1150 


<210> 196
<211> 1150
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis TX0012

<400> 196
Met Tyr Ser Ile Gly Leu Asp Leu Gly Ile Ser Ser Val Gly Trp Ser 
1               5                   10                  15      


Val Ile Asp Glu Arg Thr Gly Asn Val Ile Asp Leu Gly Val Arg Leu 
            20                  25                  30          


Phe Ser Ala Lys Asn Ser Glu Lys Asn Leu Glu Arg Arg Thr Asn Arg 
        35                  40                  45              


Gly Gly Arg Arg Leu Ile Arg Arg Lys Thr Asn Arg Leu Lys Asp Ala 
    50                  55                  60                  


Lys Lys Ile Leu Ala Ala Val Gly Phe Tyr Glu Asp Lys Ser Leu Lys 
65                  70                  75                  80  


Asn Ser Cys Pro Tyr Gln Leu Arg Val Lys Gly Leu Thr Glu Pro Leu 
                85                  90                  95      


Ser Arg Gly Glu Ile Tyr Lys Val Thr Leu His Ile Leu Lys Lys Arg 
            100                 105                 110         


Gly Ile Ser Tyr Leu Asp Glu Val Asp Thr Glu Ala Ala Lys Glu Ser 
        115                 120                 125             


Gln Asp Tyr Lys Glu Gln Val Arg Lys Asn Ala Gln Leu Leu Thr Lys 
    130                 135                 140                 


Tyr Thr Pro Gly Gln Ile Gln Leu Gln Arg Leu Lys Glu Asn Asn Arg 
145                 150                 155                 160 


Val Lys Thr Gly Ile Asn Ala Gln Gly Asn Tyr Gln Leu Asn Val Phe 
                165                 170                 175     


Lys Val Ser Ala Tyr Ala Asn Glu Leu Ala Thr Ile Leu Lys Thr Gln 
            180                 185                 190         


Gln Ala Phe Tyr Pro Asn Glu Leu Thr Asp Asp Trp Ile Ala Leu Phe 
        195                 200                 205             


Val Gln Pro Gly Ile Ala Glu Glu Ala Gly Leu Ile Tyr Arg Lys Arg 
    210                 215                 220                 


Pro Tyr Tyr His Gly Pro Gly Asn Glu Ala Asn Asn Ser Pro Tyr Gly 
225                 230                 235                 240 


Arg Trp Ser Asp Phe Gln Lys Thr Gly Glu Pro Ala Thr Asn Ile Phe 
                245                 250                 255     


Asp Lys Leu Ile Gly Lys Asp Phe Gln Gly Glu Leu Arg Ala Ser Gly 
            260                 265                 270         


Leu Ser Leu Ser Ala Gln Gln Tyr Asn Leu Leu Asn Asp Leu Thr Asn 
        275                 280                 285             


Leu Lys Ile Asp Gly Glu Val Pro Leu Ser Ser Glu Gln Lys Glu Tyr 
    290                 295                 300                 


Ile Leu Thr Glu Leu Met Thr Lys Glu Phe Thr Arg Phe Gly Val Asn 
305                 310                 315                 320 


Asp Val Val Lys Leu Leu Gly Val Lys Lys Glu Arg Leu Ser Gly Trp 
                325                 330                 335     


Arg Leu Asp Lys Lys Gly Lys Pro Glu Ile His Thr Leu Lys Gly Tyr 
            340                 345                 350         


Arg Asn Trp Arg Lys Ile Phe Ala Glu Ala Gly Ile Asp Leu Ala Thr 
        355                 360                 365             


Leu Pro Thr Glu Thr Ile Asp Cys Leu Ala Lys Val Leu Thr Leu Asn 
    370                 375                 380                 


Thr Glu Arg Glu Gly Ile Glu Asn Thr Leu Ala Phe Glu Leu Pro Glu 
385                 390                 395                 400 


Leu Ser Glu Ser Val Lys Leu Leu Val Leu Asp Arg Tyr Lys Glu Leu 
                405                 410                 415     


Ser Gln Ser Ile Ser Thr Gln Ser Trp His Arg Phe Ser Leu Lys Thr 
            420                 425                 430         


Leu His Leu Leu Ile Pro Glu Leu Met Asn Ala Thr Ser Glu Gln Asn 
        435                 440                 445             


Thr Leu Leu Glu Gln Phe Gln Leu Lys Ser Asp Val Arg Lys Arg Tyr 
    450                 455                 460                 


Ser Glu Tyr Lys Lys Leu Pro Thr Lys Asp Val Leu Ala Glu Ile Tyr 
465                 470                 475                 480 


Asn Pro Thr Val Asn Lys Thr Val Ser Gln Ala Phe Lys Val Ile Asp 
                485                 490                 495     


Ala Leu Leu Val Lys Tyr Gly Lys Glu Gln Ile Arg Tyr Ile Thr Ile 
            500                 505                 510         


Glu Met Pro Arg Asp Asp Asn Glu Glu Asp Glu Lys Lys Arg Ile Lys 
        515                 520                 525             


Glu Leu His Ala Lys Asn Ser Gln Arg Lys Asn Asp Ser Gln Ser Tyr 
    530                 535                 540                 


Phe Met Gln Lys Ser Gly Trp Ser Gln Glu Lys Phe Gln Thr Thr Ile 
545                 550                 555                 560 


Gln Lys Asn Arg Arg Phe Leu Ala Lys Leu Leu Tyr Tyr Tyr Glu Gln 
                565                 570                 575     


Asp Gly Ile Cys Ala Tyr Thr Gly Leu Pro Ile Ser Pro Glu Leu Leu 
            580                 585                 590         


Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 
        595                 600                 605             


Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 
    610                 615                 620                 


Gln Val Lys Gly Gln Gln Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 
625                 630                 635                 640 


Phe Lys Lys Ile Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gln Lys 
                645                 650                 655     


Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 
            660                 665                 670         


Glu Thr Arg Asn Ile Phe Asp Ser Glu Gln Val Glu Lys Phe Leu Ala 
        675                 680                 685             


Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 
    690                 695                 700                 


Leu Gln Ser Phe Phe Thr Asn Gln Glu Thr Lys Val Arg Val Val Asn 
705                 710                 715                 720 


Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 
                725                 730                 735     


Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 
            740                 745                 750         


Ala Val Thr Ser Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 
        755                 760                 765             


Glu Glu Thr Gly Glu Lys Val Met Arg Glu Ile Asp Phe Glu Thr Gly 
    770                 775                 780                 


Glu Ile Val Asn Glu Met Ser Tyr Trp Glu Phe Lys Lys Ser Lys Lys 
785                 790                 795                 800 


Tyr Glu Arg Lys Thr Tyr Gln Val Lys Trp Pro Asn Phe Arg Glu Gln 
                805                 810                 815     


Leu Lys Pro Val Asn Leu His Pro Arg Ile Lys Phe Ser His Gln Val 
            820                 825                 830         


Asp Arg Lys Ala Asn Arg Lys Leu Ser Asp Ala Thr Ile Tyr Ser Val 
        835                 840                 845             


Arg Glu Lys Thr Glu Val Lys Thr Leu Lys Ser Gly Lys Gln Lys Ile 
    850                 855                 860                 


Thr Thr Asp Glu Tyr Thr Ile Gly Lys Ile Lys Asp Ile Tyr Thr Leu 
865                 870                 875                 880 


Asp Gly Trp Glu Ala Phe Lys Lys Lys Gln Asp Lys Leu Leu Met Lys 
                885                 890                 895     


Asp Leu Asp Glu Lys Thr Tyr Glu Arg Leu Leu Ser Ile Ala Glu Thr 
            900                 905                 910         


Thr Pro Asp Phe Gln Glu Val Glu Glu Lys Asn Gly Lys Val Lys Arg 
        915                 920                 925             


Val Lys Arg Ser Pro Phe Ala Val Tyr Cys Glu Glu Asn Asp Ile Pro 
    930                 935                 940                 


Ala Ile Gln Lys Tyr Ala Lys Lys Asn Asn Gly Pro Leu Ile Arg Ser 
945                 950                 955                 960 


Leu Lys Tyr Tyr Asp Gly Lys Leu Asn Lys His Ile Asn Ile Thr Lys 
                965                 970                 975     


Asp Ser Gln Gly Arg Pro Val Glu Lys Thr Lys Asn Gly Arg Lys Val 
            980                 985                 990         


Thr Leu Gln Ser Leu Lys Pro Tyr  Arg Tyr Asp Ile Tyr  Gln Asp Leu 
        995                 1000                 1005             


Glu Thr  Lys Ala Tyr Tyr Thr  Val Gln Leu Tyr Tyr  Ser Asp Leu 
    1010                 1015                 1020             


Arg Phe  Val Glu Gly Lys Tyr  Gly Ile Thr Glu Lys  Glu Tyr Met 
    1025                 1030                 1035             


Lys Lys  Val Ala Glu Gln Thr  Lys Gly Gln Val Val  Arg Phe Cys 
    1040                 1045                 1050             


Phe Ser  Leu Gln Lys Asn Asp  Gly Leu Glu Ile Glu  Trp Lys Asp 
    1055                 1060                 1065             


Ser Gln  Arg Tyr Asp Val Arg  Phe Tyr Asn Phe Gln  Ser Ala Asn 
    1070                 1075                 1080             


Ser Ile  Asn Phe Lys Gly Leu  Glu Gln Glu Met Met  Pro Ala Glu 
    1085                 1090                 1095             


Asn Gln  Phe Lys Gln Lys Pro  Tyr Asn Asn Gly Ala  Ile Asn Leu 
    1100                 1105                 1110             


Asn Ile  Ala Lys Tyr Gly Lys  Glu Gly Lys Lys Leu  Arg Lys Phe 
    1115                 1120                 1125             


Asn Thr  Asp Ile Leu Gly Lys  Lys His Tyr Leu Phe  Tyr Glu Lys 
    1130                 1135                 1140             


Glu Pro  Lys Asn Ile Ile Lys  
    1145                 1150 


<210> 197
<211> 1337
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis TX0470

<400> 197
Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Ala Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Thr Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Asn Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Thr His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Val Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Thr Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Ile Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210> 198
<211> 1150
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis TX1342

<400> 198
Met Tyr Ser Ile Gly Leu Asp Leu Gly Val Ser Ser Val Gly Trp Ser 
1               5                   10                  15      


Val Ile Asp Glu Arg Thr Gly Asn Val Ile Asp Leu Gly Val Arg Leu 
            20                  25                  30          


Phe Ser Ala Lys Asn Ser Glu Lys Asn Leu Glu Arg Arg Thr Asn Arg 
        35                  40                  45              


Gly Gly Arg Arg Leu Ile Arg Arg Lys Thr Asn Arg Leu Lys Asp Ala 
    50                  55                  60                  


Lys Lys Ile Leu Ala Ala Val Gly Phe Tyr Glu Asp Lys Ser Leu Lys 
65                  70                  75                  80  


Asn Ser Cys Pro Tyr Gln Leu Arg Val Lys Gly Leu Thr Glu Pro Leu 
                85                  90                  95      


Ser Lys Gly Glu Ile Tyr Lys Val Thr Leu His Ile Leu Lys Lys Arg 
            100                 105                 110         


Gly Ile Ser Tyr Leu Asp Glu Asp Asp Thr Glu Ala Ala Lys Glu Ser 
        115                 120                 125             


Gln Asp Tyr Lys Glu Gln Val Arg Glu Asn Ala Gln Leu Leu Thr Lys 
    130                 135                 140                 


Tyr Thr Pro Gly Gln Ile Gln Leu Gln Arg Leu Lys Glu Asn Asn Arg 
145                 150                 155                 160 


Val Lys Thr Gly Ile Asn Ala Gln Gly Asn Tyr Gln Leu Asn Val Phe 
                165                 170                 175     


Lys Val Ser Ala Tyr Ala Asn Glu Leu Ala Thr Ile Leu Lys Thr Gln 
            180                 185                 190         


Gln Ala Phe Tyr Pro Asn Glu Leu Thr Asp Asp Trp Ile Ala Leu Phe 
        195                 200                 205             


Val Gln Pro Gly Ile Ala Glu Glu Ala Gly Leu Ile Tyr Arg Lys Arg 
    210                 215                 220                 


Pro Tyr Tyr His Gly Pro Gly Asn Glu Ala Asn Asn Ser Pro Tyr Gly 
225                 230                 235                 240 


Arg Trp Ser Asp Phe Lys Lys Thr Gly Gln Pro Ala Thr Asn Ile Phe 
                245                 250                 255     


Asp Lys Leu Ile Gly Lys Asp Phe Gln Gly Glu Leu Arg Ala Ser Gly 
            260                 265                 270         


Leu Ser Leu Ser Ala Gln Gln Tyr Asn Leu Leu Asn Asp Leu Thr Asn 
        275                 280                 285             


Leu Lys Ile Asp Gly Glu Ile Pro Leu Ser Pro Glu Gln Lys Glu Tyr 
    290                 295                 300                 


Ile Leu Ala Glu Leu Met Thr Lys Glu Phe Thr Arg Phe Gly Ile Asn 
305                 310                 315                 320 


Asp Val Ala Lys Leu Leu Gly Val Lys Lys Glu Arg Leu Ser Gly Trp 
                325                 330                 335     


Arg Leu Asp Lys Lys Gly Lys Pro Glu Ile His Thr Leu Lys Gly Tyr 
            340                 345                 350         


Arg Asn Trp Arg Lys Ile Phe Ala Glu Ser Gly Ile Asp Leu Ala Thr 
        355                 360                 365             


Leu Pro Thr Glu Thr Ile Asp Cys Leu Ala Lys Val Leu Thr Leu Asn 
    370                 375                 380                 


Thr Glu Arg Glu Gly Ile Glu Asn Thr Leu Ala Phe Glu Leu Pro Glu 
385                 390                 395                 400 


Leu Ala Glu Ser Val Lys Leu Leu Val Leu Asp Arg Tyr Lys Glu Leu 
                405                 410                 415     


Ser Gln Ser Val Ser Thr Gln Ala Trp His Arg Phe Ser Leu Lys Thr 
            420                 425                 430         


Leu His Leu Leu Ile Pro Glu Leu Met Asn Ala Thr Ser Glu Gln Asn 
        435                 440                 445             


Thr Leu Leu Glu Gln Phe Gln Leu Lys Ser Asp Val Arg Lys Arg Tyr 
    450                 455                 460                 


Ser Glu Tyr Lys Lys Leu Pro Thr Lys Asp Val Leu Thr Glu Ile Tyr 
465                 470                 475                 480 


Asn Pro Thr Val Asn Lys Thr Val Ser Gln Ala Phe Lys Val Ile Asp 
                485                 490                 495     


Ala Leu Leu Val Lys Tyr Gly Lys Glu Gln Ile Arg Tyr Ile Thr Ile 
            500                 505                 510         


Glu Met Pro Arg Asp Asp Asn Glu Glu Asp Glu Lys Lys Arg Ile Lys 
        515                 520                 525             


Glu Leu His Ala Lys Asn Ser Gln Arg Lys Asn Asp Ser Gln Ser Tyr 
    530                 535                 540                 


Phe Met Gln Lys Ser Gly Trp Ser Gln Glu Lys Phe Gln Thr Thr Ile 
545                 550                 555                 560 


Gln Lys Asn Arg Arg Phe Leu Ala Lys Leu Leu Tyr Tyr Tyr Glu Gln 
                565                 570                 575     


Asp Gly Ile Cys Ala Tyr Thr Gly Leu Ser Ile Ser Pro Glu Leu Leu 
            580                 585                 590         


Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 
        595                 600                 605             


Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 
    610                 615                 620                 


Gln Val Lys Gly Gln Gln Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 
625                 630                 635                 640 


Phe Lys Lys Ile Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gln Lys 
                645                 650                 655     


Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 
            660                 665                 670         


Glu Thr Arg Asn Ile Phe Asp Ser Glu Gln Val Glu Lys Phe Leu Ala 
        675                 680                 685             


Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 
    690                 695                 700                 


Leu Gln Ser Phe Phe Ala Asn Gln Glu Thr Lys Val Arg Val Val Asn 
705                 710                 715                 720 


Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 
                725                 730                 735     


Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 
            740                 745                 750         


Ala Val Thr Pro Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 
        755                 760                 765             


Glu Glu Thr Gly Glu Lys Val Met Arg Glu Ile Asp Phe Glu Thr Gly 
    770                 775                 780                 


Glu Ile Val Asp Glu Met Ser Tyr Arg Glu Phe Lys Lys Ser Lys Lys 
785                 790                 795                 800 


Tyr Glu Arg Lys Thr Tyr Gln Val Lys Trp Pro Asn Phe Arg Glu Gln 
                805                 810                 815     


Leu Lys Pro Val Asn Leu His Pro Arg Ile Lys Phe Ser His Gln Val 
            820                 825                 830         


Asp Arg Lys Ala Asn Arg Lys Leu Ser Asp Ala Thr Ile Tyr Ser Val 
        835                 840                 845             


Arg Glu Lys Thr Glu Val Lys Thr Leu Lys Ser Gly Lys Gln Lys Ile 
    850                 855                 860                 


Thr Thr Asp Glu Tyr Thr Ile Gly Lys Ile Lys Asp Ile Tyr Thr Val 
865                 870                 875                 880 


Asp Gly Trp Glu Ala Phe Lys Lys Lys Gln Asp Lys Leu Leu Met Lys 
                885                 890                 895     


Asp Leu Asp Glu Lys Thr Tyr Glu Arg Leu Leu Ser Ile Ala Glu Thr 
            900                 905                 910         


Thr Pro Asp Phe Gln Glu Val Glu Glu Lys Asn Gly Lys Val Lys Arg 
        915                 920                 925             


Val Lys Arg Ser Pro Phe Ala Val Tyr Cys Glu Glu Asn Asp Ile Pro 
    930                 935                 940                 


Ala Ile Arg Lys Tyr Ala Lys Asn Asn Asn Gly Pro Leu Ile Arg Ser 
945                 950                 955                 960 


Leu Lys Tyr Tyr Asp Gly Lys Leu Asn Lys His Ile Asn Ile Thr Lys 
                965                 970                 975     


Asp Ser Gln Gly Arg Pro Val Glu Lys Thr Lys Asn Gly Arg Lys Val 
            980                 985                 990         


Thr Leu Gln Ser Leu Lys Pro Tyr  Arg Tyr Asp Ile Tyr  Gln Asp Leu 
        995                 1000                 1005             


Glu Thr  Lys Ala Tyr Tyr Thr  Val Gln Leu Tyr Tyr  Ser Asp Leu 
    1010                 1015                 1020             


Arg Phe  Val Glu Gly Lys Tyr  Gly Ile Thr Glu Lys  Glu Tyr Met 
    1025                 1030                 1035             


Lys Lys  Val Ala Glu Gln Thr  Lys Gly Gln Val Val  Arg Phe Cys 
    1040                 1045                 1050             


Phe Ser  Leu Gln Lys Asn Asp  Gly Leu Glu Ile Glu  Trp Lys Asp 
    1055                 1060                 1065             


Ser Gln  Cys Tyr Asp Val Arg  Phe Tyr Asn Phe Gln  Ser Ala Asn 
    1070                 1075                 1080             


Ser Ile  Asn Phe Lys Gly Leu  Glu Gln Glu Met Met  Pro Ala Glu 
    1085                 1090                 1095             


Asn Gln  Phe Lys Gln Lys Pro  Tyr Asn Asn Gly Ala  Ile Asn Leu 
    1100                 1105                 1110             


Asn Ile  Ala Lys Tyr Gly Lys  Glu Gly Lys Lys Leu  Arg Lys Phe 
    1115                 1120                 1125             


Asn Thr  Asp Ile Leu Gly Lys  Lys His Tyr Leu Tyr  Tyr Glu Lys 
    1130                 1135                 1140             


Glu Pro  Lys Asn Ile Ile Lys  
    1145                 1150 


<210> 199
<211> 1337
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis TX4244

<400> 199
Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Asp Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Gly Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Leu Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Asn Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Thr Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Ile Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210> 200
<211> 1339
<212> PRT
<213> Enterococcus faecium


<220>
<223> Enterococcus faecium 1,141,733

<400> 200
Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Asp Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Ala Lys Leu Gln Phe Ser Lys 
            260                 265                 270         


Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly Asp 
        275                 280                 285             


Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala Val 
    290                 295                 300                 


Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala Lys 
305                 310                 315                 320 


Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp Leu 
                325                 330                 335     


Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr Arg 
            340                 345                 350         


Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile Glu 
        355                 360                 365             


Gly His Ala Thr Gln Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu Leu 
    370                 375                 380                 


Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln Glu 
385                 390                 395                 400 


Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro His 
                405                 410                 415     


Gln Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys Lys 
            420                 425                 430         


His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu Leu 
        435                 440                 445             


Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln Glu 
    450                 455                 460                 


Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile Lys 
465                 470                 475                 480 


Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val Arg 
                485                 490                 495     


Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Met Pro His Asn Lys 
            500                 505                 510         


Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn Tyr 
    530                 535                 540                 


Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu Lys 
545                 550                 555                 560 


Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu Lys 
                565                 570                 575     


Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe Asn 
            580                 585                 590         


Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn Lys 
        595                 600                 605             


Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met Phe 
    610                 615                 620                 


Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met Ile 
625                 630                 635                 640 


Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile Ile 
                645                 650                 655     


Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu Ile 
705                 710                 715                 720 


Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile Val 
                725                 730                 735     


Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro Ala 
        755                 760                 765             


Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg Gly 
    770                 775                 780                 


Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu Lys 
785                 790                 795                 800 


Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser Ser 
                805                 810                 815     


Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp 
            820                 825                 830         


Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile Asp 
    850                 855                 860                 


Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp Asp 
865                 870                 875                 880 


Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr Asp 
                885                 890                 895     


Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu Thr 
            900                 905                 910         


Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu His 
    930                 935                 940                 


His Arg Phe Asn Lys Ala Glu Asp Thr Asn Glu Pro Ile Arg Lys Val 
945                 950                 955                 960 


Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn Arg 
                965                 970                 975     


Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Gly Val Val  Ala Leu Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Gln  Leu Ala Pro Glu Phe  Val Tyr Gly Glu Tyr  Leu Lys Phe 
    1010                 1015                 1020             


Asn Ala  His Lys Ala Asn Lys  Ala Thr Val Lys Lys  Glu Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Lys Phe Phe  Glu Ser Asp Thr Pro  Val Cys Asp 
    1040                 1045                 1050             


Glu Asn  Gly Glu Ile Phe Trp  Asp Lys Ser Lys Ser  Ile Ala Gln 
    1055                 1060                 1065             


Val Lys  Lys Val Ile Asn His  His His Met Asn Ile  Val Lys Lys 
    1070                 1075                 1080             


Thr Glu  Ile Gln Lys Gly Gly  Phe Ser Lys Glu Thr  Val Glu Pro 
    1085                 1090                 1095             


Lys Lys  Asp Ser Ser Lys Leu  Leu Pro Arg Lys Asn  Asn Trp Asp 
    1100                 1105                 1110             


Pro Ala  Lys Tyr Gly Gly Leu  Gly Ser Pro Asn Val  Ala Tyr Thr 
    1115                 1120                 1125             


Val Ala  Phe Thr Tyr Glu Lys  Gly Lys Ala Arg Lys  Arg Thr Asn 
    1130                 1135                 1140             


Ala Leu  Glu Gly Ile Thr Ile  Met Glu Arg Glu Ala  Phe Glu Gln 
    1145                 1150                 1155             


Ser Pro  Val Leu Phe Leu Lys  Asn Lys Gly Tyr Glu  Gln Ala Glu 
    1160                 1165                 1170             


Ile Glu  Met Lys Leu Pro Lys  Tyr Ala Leu Phe Glu  Leu Glu Asn 
    1175                 1180                 1185             


Gly Arg  Lys Arg Met Val Ala  Ser Asn Lys Glu Ala  Gln Lys Ala 
    1190                 1195                 1200             


Asn Ser  Phe Leu Leu Pro Glu  His Leu Val Thr Leu  Leu Tyr His 
    1205                 1210                 1215             


Ala Lys  Gln Tyr Asp Glu Ile  Ser His Lys Glu Ser  Phe Asp Tyr 
    1220                 1225                 1230             


Val Asn  Glu His His Lys Glu  Phe Ser Glu Val Phe  Ala Arg Val 
    1235                 1240                 1245             


Leu Glu  Phe Ala Gly Lys Tyr  Thr Leu Ala Glu Lys  Asn Ile Glu 
    1250                 1255                 1260             


Lys Leu  Glu Lys Ile Tyr Lys  Glu Asn Gln Thr Asp  Asp Leu Ala 
    1265                 1270                 1275             


Lys Leu  Ala Ser Ser Phe Val  Asn Leu Met Gln Phe  Asn Ala Met 
    1280                 1285                 1290             


Gly Ala  Pro Ala Asp Phe Lys  Phe Phe Asp Val Thr  Ile Pro Arg 
    1295                 1300                 1305             


Lys Arg  Tyr Thr Ser Leu Thr  Glu Ile Trp Gln Ser  Thr Ile Ile 
    1310                 1315                 1320             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Arg Met Gly 
    1325                 1330                 1335             


Lys 
    


<210> 201
<211> 1340
<212> PRT
<213> Enterococcus faecium


<220>
<223> Enterococcus faecium 1,231,408

<400> 201
Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Pro Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Gly Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Glu Ala Lys Leu Gln Phe Ser 
            260                 265                 270         


Lys Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly 
        275                 280                 285             


Asp Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala 
    290                 295                 300                 


Val Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala 
305                 310                 315                 320 


Lys Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp 
                325                 330                 335     


Leu Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr 
            340                 345                 350         


Arg Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile 
        355                 360                 365             


Glu Gly His Ala Thr Gln Glu Ala Phe Tyr Lys Phe Val Lys Lys Glu 
    370                 375                 380                 


Leu Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln 
385                 390                 395                 400 


Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro 
                405                 410                 415     


His Gln Ile His Leu Ser Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys 
            420                 425                 430         


Lys His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu 
        435                 440                 445             


Leu Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln 
    450                 455                 460                 


Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 
465                 470                 475                 480 


Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 
                485                 490                 495     


Arg Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Met Pro His Asn 
            500                 505                 510         


Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr 
        515                 520                 525             


Asn Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn 
    530                 535                 540                 


Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 
545                 550                 555                 560 


Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu 
                565                 570                 575     


Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 
            580                 585                 590         


Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 
        595                 600                 605             


Lys Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 
    610                 615                 620                 


Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 
625                 630                 635                 640 


Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 
                645                 650                 655     


Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Lys Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile 
        675                 680                 685             


Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 
    690                 695                 700                 


Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 
705                 710                 715                 720 


Ile Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 
                725                 730                 735     


Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
            740                 745                 750         


Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 
        755                 760                 765             


Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg 
    770                 775                 780                 


Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 
785                 790                 795                 800 


Lys Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 
                805                 810                 815     


Ser Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
            820                 825                 830         


Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 
        835                 840                 845             


Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 
    850                 855                 860                 


Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 
865                 870                 875                 880 


Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 
                885                 890                 895     


Asp Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu 
            900                 905                 910         


Thr Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu 
    930                 935                 940                 


His His Arg Phe Asn Lys Ala Glu Asp Thr Asn Asp Pro Ile Arg Lys 
945                 950                 955                 960 


Val Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn 
                965                 970                 975     


Arg Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Gly Val  Val Ala Leu Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Gln Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Leu Lys 
    1010                 1015                 1020             


Phe Asn  Ala His Lys Ala Asn  Lys Ala Thr Val Lys  Lys Glu Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Lys Phe  Phe Glu Ser Asp Thr  Pro Val Cys 
    1040                 1045                 1050             


Asp Glu  Asn Gly Glu Ile Phe  Trp Asp Lys Ser Lys  Ser Ile Ala 
    1055                 1060                 1065             


Gln Val  Lys Lys Val Ile Asn  His His His Met Asn  Ile Val Lys 
    1070                 1075                 1080             


Lys Thr  Glu Ile Gln Lys Gly  Gly Phe Ser Lys Glu  Thr Val Glu 
    1085                 1090                 1095             


Pro Lys  Lys Asp Ser Ser Lys  Leu Leu Pro Arg Lys  Asn Asn Trp 
    1100                 1105                 1110             


Asp Pro  Ala Lys Tyr Gly Gly  Leu Gly Ser Pro Asn  Val Ala Tyr 
    1115                 1120                 1125             


Thr Val  Ala Phe Thr Tyr Glu  Lys Gly Lys Ala Arg  Lys Arg Thr 
    1130                 1135                 1140             


Asn Ala  Leu Glu Gly Ile Thr  Ile Met Glu Arg Glu  Ala Phe Glu 
    1145                 1150                 1155             


Gln Ser  Pro Val Leu Phe Leu  Lys Asn Lys Gly Tyr  Glu Gln Ala 
    1160                 1165                 1170             


Glu Ile  Glu Met Lys Leu Pro  Lys Tyr Ala Leu Phe  Glu Leu Glu 
    1175                 1180                 1185             


Asn Gly  Arg Lys Arg Met Val  Ala Ser Asn Lys Glu  Ala Gln Lys 
    1190                 1195                 1200             


Ala Asn  Ser Phe Leu Leu Pro  Glu His Leu Val Thr  Leu Leu Tyr 
    1205                 1210                 1215             


His Ala  Lys Gln Tyr Asp Glu  Ile Ser His Lys Glu  Ser Phe Asp 
    1220                 1225                 1230             


Tyr Val  Asn Glu His His Lys  Glu Phe Ser Glu Val  Phe Ala Arg 
    1235                 1240                 1245             


Val Leu  Glu Phe Ala Gly Lys  Tyr Thr Leu Ala Glu  Lys Asn Ile 
    1250                 1255                 1260             


Glu Lys  Leu Glu Lys Ile Tyr  Lys Glu Asn Gln Thr  Asp Asp Leu 
    1265                 1270                 1275             


Ala Lys  Leu Ala Ser Ser Phe  Val Asn Leu Met Gln  Phe Asn Ala 
    1280                 1285                 1290             


Met Gly  Ala Pro Ala Asp Phe  Lys Phe Phe Asp Val  Thr Ile Pro 
    1295                 1300                 1305             


Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile Trp Gln  Ser Thr Ile 
    1310                 1315                 1320             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Arg Met 
    1325                 1330                 1335             


Gly Lys  
    1340 


<210> 202
<211> 1339
<212> PRT
<213> Enterococcus faecium


<220>
<223> Enterococcus faecium E1133

<400> 202
Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Asp Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Ala Lys Leu Gln Phe Ser Lys 
            260                 265                 270         


Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly Asp 
        275                 280                 285             


Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala Val 
    290                 295                 300                 


Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala Lys 
305                 310                 315                 320 


Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp Leu 
                325                 330                 335     


Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr Arg 
            340                 345                 350         


Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile Glu 
        355                 360                 365             


Gly His Ala Thr Gln Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu Leu 
    370                 375                 380                 


Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln Glu 
385                 390                 395                 400 


Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro His 
                405                 410                 415     


Gln Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys Lys 
            420                 425                 430         


His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu Leu 
        435                 440                 445             


Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln Glu 
    450                 455                 460                 


Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile Lys 
465                 470                 475                 480 


Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val Arg 
                485                 490                 495     


Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Ile Pro His Asn Lys 
            500                 505                 510         


Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn Tyr 
    530                 535                 540                 


Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu Lys 
545                 550                 555                 560 


Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu Lys 
                565                 570                 575     


Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe Asn 
            580                 585                 590         


Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn Lys 
        595                 600                 605             


Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met Phe 
    610                 615                 620                 


Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met Ile 
625                 630                 635                 640 


Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile Ile 
                645                 650                 655     


Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu Ile 
705                 710                 715                 720 


Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile Val 
                725                 730                 735     


Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro Ala 
        755                 760                 765             


Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg Gly 
    770                 775                 780                 


Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu Lys 
785                 790                 795                 800 


Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser Ser 
                805                 810                 815     


Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp 
            820                 825                 830         


Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile Asp 
    850                 855                 860                 


Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp Asp 
865                 870                 875                 880 


Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr Asp 
                885                 890                 895     


Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu Thr 
            900                 905                 910         


Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu His 
    930                 935                 940                 


His Arg Phe Asn Lys Ala Glu Asp Thr Asn Glu Pro Ile Arg Lys Val 
945                 950                 955                 960 


Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn Arg 
                965                 970                 975     


Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Gly Val Val  Ala Leu Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Gln  Leu Ala Pro Glu Phe  Val Tyr Gly Glu Tyr  Leu Lys Phe 
    1010                 1015                 1020             


Asn Ala  His Lys Ala Asn Lys  Ala Thr Val Lys Lys  Glu Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Lys Phe Phe  Glu Ser Asp Thr Pro  Val Cys Asp 
    1040                 1045                 1050             


Glu Asn  Gly Glu Ile Phe Trp  Asp Lys Ser Lys Ser  Ile Ala Gln 
    1055                 1060                 1065             


Val Lys  Lys Val Ile Asn His  His His Met Asn Ile  Val Lys Lys 
    1070                 1075                 1080             


Thr Glu  Ile Gln Lys Gly Gly  Phe Ser Glu Glu Thr  Val Glu Pro 
    1085                 1090                 1095             


Lys Lys  Asp Ser Ser Lys Leu  Leu Pro Arg Lys Asn  Asn Trp Asp 
    1100                 1105                 1110             


Pro Ala  Lys Tyr Gly Gly Leu  Gly Ser Pro Asn Val  Ala Tyr Thr 
    1115                 1120                 1125             


Val Ala  Phe Thr Tyr Glu Lys  Gly Lys Ala Arg Lys  Arg Thr Asn 
    1130                 1135                 1140             


Ala Leu  Glu Gly Ile Thr Ile  Met Glu Arg Glu Ala  Phe Glu Gln 
    1145                 1150                 1155             


Ser Pro  Val Leu Phe Leu Lys  Asn Lys Gly Tyr Glu  Gln Ala Glu 
    1160                 1165                 1170             


Ile Glu  Met Lys Leu Pro Lys  Tyr Ala Leu Phe Glu  Leu Glu Asn 
    1175                 1180                 1185             


Gly Arg  Lys Arg Met Val Ala  Ser Asn Lys Glu Ala  Gln Lys Ala 
    1190                 1195                 1200             


Asn Ser  Phe Leu Leu Pro Glu  His Leu Val Thr Leu  Leu Tyr His 
    1205                 1210                 1215             


Ala Lys  Gln Tyr Asp Glu Ile  Ser His Lys Glu Ser  Phe Asp Tyr 
    1220                 1225                 1230             


Val Asn  Glu His His Lys Glu  Phe Ser Glu Val Phe  Ala Arg Val 
    1235                 1240                 1245             


Leu Glu  Phe Ala Gly Lys Tyr  Thr Leu Ala Glu Lys  Asn Ile Glu 
    1250                 1255                 1260             


Lys Leu  Glu Lys Ile Tyr Lys  Glu Asn Gln Thr Asp  Asp Leu Ala 
    1265                 1270                 1275             


Lys Leu  Ala Ser Ser Phe Val  Asn Leu Met Gln Phe  Asn Ala Met 
    1280                 1285                 1290             


Gly Ala  Pro Ala Asp Phe Lys  Phe Phe Asp Val Thr  Ile Pro Arg 
    1295                 1300                 1305             


Lys Arg  Tyr Thr Ser Leu Thr  Glu Ile Trp Gln Ser  Thr Ile Ile 
    1310                 1315                 1320             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Arg Met Gly 
    1325                 1330                 1335             


Lys 
    


<210> 203
<211> 1340
<212> PRT
<213> Enterococcus faecium


<220>
<223> Enterococcus faecium E3083

<400> 203
Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Asp Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Glu Ala Lys Leu Gln Phe Ser 
            260                 265                 270         


Lys Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly 
        275                 280                 285             


Asp Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala 
    290                 295                 300                 


Val Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala 
305                 310                 315                 320 


Lys Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp 
                325                 330                 335     


Leu Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr 
            340                 345                 350         


Arg Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile 
        355                 360                 365             


Glu Gly His Ala Thr Gln Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu 
    370                 375                 380                 


Leu Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln 
385                 390                 395                 400 


Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro 
                405                 410                 415     


His Gln Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys 
            420                 425                 430         


Lys His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu 
        435                 440                 445             


Leu Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln 
    450                 455                 460                 


Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 
465                 470                 475                 480 


Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 
                485                 490                 495     


Arg Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Ile Pro His Asn 
            500                 505                 510         


Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr 
        515                 520                 525             


Asn Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn 
    530                 535                 540                 


Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 
545                 550                 555                 560 


Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu 
                565                 570                 575     


Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 
            580                 585                 590         


Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 
        595                 600                 605             


Lys Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 
    610                 615                 620                 


Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 
625                 630                 635                 640 


Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 
                645                 650                 655     


Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Lys Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile 
        675                 680                 685             


Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 
    690                 695                 700                 


Asn Cys Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 
705                 710                 715                 720 


Ile Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 
                725                 730                 735     


Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
            740                 745                 750         


Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 
        755                 760                 765             


Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg 
    770                 775                 780                 


Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 
785                 790                 795                 800 


Lys Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 
                805                 810                 815     


Ser Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
            820                 825                 830         


Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 
        835                 840                 845             


Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 
    850                 855                 860                 


Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 
865                 870                 875                 880 


Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 
                885                 890                 895     


Asp Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu 
            900                 905                 910         


Thr Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu 
    930                 935                 940                 


His His Arg Phe Asn Lys Ala Glu Asp Thr Asn Glu Pro Ile Arg Lys 
945                 950                 955                 960 


Val Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn 
                965                 970                 975     


Arg Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Gly Val  Val Ala Leu Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Gln Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Leu Lys 
    1010                 1015                 1020             


Phe Asn  Ala His Lys Ala Asn  Lys Ala Thr Val Lys  Lys Glu Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Lys Phe  Phe Glu Ser Asp Thr  Pro Val Cys 
    1040                 1045                 1050             


Asp Glu  Asn Gly Glu Ile Phe  Trp Asp Lys Ser Lys  Ser Ile Ala 
    1055                 1060                 1065             


Gln Val  Lys Lys Val Ile Asn  His His His Met Asn  Ile Val Lys 
    1070                 1075                 1080             


Lys Thr  Glu Ile Gln Lys Gly  Gly Phe Ser Lys Glu  Thr Val Glu 
    1085                 1090                 1095             


Pro Lys  Lys Asp Ser Ser Lys  Leu Leu Pro Arg Lys  Asn Asn Trp 
    1100                 1105                 1110             


Asp Pro  Thr Lys Tyr Gly Gly  Leu Gly Ser Pro Asn  Val Ala Tyr 
    1115                 1120                 1125             


Thr Val  Ala Phe Thr Tyr Glu  Lys Gly Lys Ala Arg  Lys Arg Thr 
    1130                 1135                 1140             


Asn Ala  Leu Glu Gly Ile Thr  Ile Met Glu Arg Glu  Ala Phe Glu 
    1145                 1150                 1155             


Gln Ser  Pro Val Leu Phe Leu  Lys Asn Lys Gly Tyr  Glu Gln Ala 
    1160                 1165                 1170             


Glu Ile  Glu Met Lys Leu Pro  Lys Tyr Ala Leu Phe  Glu Leu Glu 
    1175                 1180                 1185             


Asn Gly  Arg Lys Arg Met Val  Ala Ser Asn Lys Glu  Ala Gln Lys 
    1190                 1195                 1200             


Ala Asn  Ser Phe Leu Leu Pro  Glu His Leu Val Thr  Leu Leu Tyr 
    1205                 1210                 1215             


His Ala  Lys Gln Tyr Asp Glu  Ile Ser His Lys Glu  Ser Phe Asp 
    1220                 1225                 1230             


Tyr Val  Asn Glu His His Lys  Glu Phe Ser Glu Val  Phe Ala Arg 
    1235                 1240                 1245             


Val Leu  Glu Phe Ala Gly Lys  Tyr Thr Leu Ala Glu  Lys Asn Ile 
    1250                 1255                 1260             


Glu Lys  Leu Glu Lys Ile Tyr  Lys Glu Asn Gln Thr  Asp Asp Leu 
    1265                 1270                 1275             


Ala Lys  Leu Ala Ser Ser Phe  Val Asn Leu Met Gln  Phe Asn Ala 
    1280                 1285                 1290             


Met Gly  Ala Pro Ala Asp Phe  Lys Phe Phe Asp Val  Thr Ile Pro 
    1295                 1300                 1305             


Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile Trp Gln  Ser Thr Ile 
    1310                 1315                 1320             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Arg Met 
    1325                 1330                 1335             


Gly Lys  
    1340 


<210> 204
<211> 1340
<212> PRT
<213> Enterococcus faecium


<220>
<223> Enterococcus faecium PC4.1

<400> 204
Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Asp Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Glu Ala Lys Leu Gln Phe Ser 
            260                 265                 270         


Lys Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly 
        275                 280                 285             


Asp Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala 
    290                 295                 300                 


Val Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala 
305                 310                 315                 320 


Lys Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp 
                325                 330                 335     


Leu Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr 
            340                 345                 350         


Arg Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile 
        355                 360                 365             


Glu Gly His Ala Thr Gln Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu 
    370                 375                 380                 


Leu Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln 
385                 390                 395                 400 


Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro 
                405                 410                 415     


His Gln Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys 
            420                 425                 430         


Lys His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu 
        435                 440                 445             


Leu Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln 
    450                 455                 460                 


Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 
465                 470                 475                 480 


Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 
                485                 490                 495     


Arg Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Ile Pro His Asn 
            500                 505                 510         


Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr 
        515                 520                 525             


Asn Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn 
    530                 535                 540                 


Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 
545                 550                 555                 560 


Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu 
                565                 570                 575     


Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 
            580                 585                 590         


Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 
        595                 600                 605             


Lys Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 
    610                 615                 620                 


Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 
625                 630                 635                 640 


Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 
                645                 650                 655     


Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Lys Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile 
        675                 680                 685             


Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 
    690                 695                 700                 


Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 
705                 710                 715                 720 


Ile Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 
                725                 730                 735     


Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
            740                 745                 750         


Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 
        755                 760                 765             


Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg 
    770                 775                 780                 


Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 
785                 790                 795                 800 


Lys Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 
                805                 810                 815     


Ser Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
            820                 825                 830         


Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 
        835                 840                 845             


Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 
    850                 855                 860                 


Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 
865                 870                 875                 880 


Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 
                885                 890                 895     


Asp Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu 
            900                 905                 910         


Thr Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu 
    930                 935                 940                 


His His Arg Phe Asn Lys Ala Glu Asp Thr Asn Glu Pro Ile Arg Lys 
945                 950                 955                 960 


Val Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn 
                965                 970                 975     


Arg Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Gly Val  Val Ala Leu Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Gln Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Leu Lys 
    1010                 1015                 1020             


Phe Asn  Ala His Lys Ala Asn  Lys Ala Thr Val Lys  Lys Glu Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Lys Phe  Phe Glu Ser Asp Thr  Pro Val Cys 
    1040                 1045                 1050             


Asp Glu  Asn Gly Glu Ile Phe  Trp Asp Lys Ser Lys  Ser Ile Ala 
    1055                 1060                 1065             


Gln Val  Lys Lys Val Ile Asn  His His His Met Asn  Ile Val Lys 
    1070                 1075                 1080             


Lys Thr  Glu Ile Gln Lys Gly  Gly Phe Ser Lys Glu  Thr Val Glu 
    1085                 1090                 1095             


Pro Lys  Lys Asp Ser Ser Lys  Leu Leu Pro Arg Lys  Asn Asn Trp 
    1100                 1105                 1110             


Asp Pro  Ala Lys Tyr Gly Gly  Leu Gly Ser Pro Asn  Val Ala Tyr 
    1115                 1120                 1125             


Thr Val  Ala Phe Thr Tyr Glu  Lys Gly Lys Ala Arg  Lys Arg Thr 
    1130                 1135                 1140             


Asn Ala  Leu Glu Gly Ile Thr  Ile Met Glu Arg Glu  Ala Phe Glu 
    1145                 1150                 1155             


Gln Ser  Pro Val Leu Phe Leu  Lys Asn Lys Gly Tyr  Glu Gln Ala 
    1160                 1165                 1170             


Glu Ile  Glu Met Lys Leu Pro  Lys Tyr Ala Leu Phe  Glu Leu Glu 
    1175                 1180                 1185             


Asn Gly  Arg Lys Arg Met Val  Ala Ser Asn Lys Glu  Ala Gln Lys 
    1190                 1195                 1200             


Ala Asn  Ser Phe Leu Leu Pro  Glu His Leu Val Thr  Leu Leu Tyr 
    1205                 1210                 1215             


His Ala  Lys Gln Tyr Asp Glu  Ile Ser His Lys Glu  Ser Phe Asp 
    1220                 1225                 1230             


Tyr Val  Asn Glu His His Lys  Glu Phe Ser Glu Val  Phe Ala Arg 
    1235                 1240                 1245             


Val Leu  Glu Phe Ala Gly Lys  Tyr Thr Leu Ala Glu  Lys Asn Ile 
    1250                 1255                 1260             


Glu Lys  Leu Glu Lys Ile Tyr  Lys Glu Asn Gln Thr  Asp Asp Leu 
    1265                 1270                 1275             


Ala Lys  Leu Ala Ser Ser Phe  Val Asn Leu Met Gln  Phe Asn Ala 
    1280                 1285                 1290             


Met Gly  Ala Pro Ala Asp Phe  Lys Phe Phe Asp Val  Thr Ile Pro 
    1295                 1300                 1305             


Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile Trp Gln  Ser Thr Ile 
    1310                 1315                 1320             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Arg Met 
    1325                 1330                 1335             


Gly Lys  
    1340 


<210> 205
<211> 1340
<212> PRT
<213> Enterococcus faecium


<220>
<223> Enterococcus faecium TX1330

<400> 205
Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Asp Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Glu Ala Lys Leu Gln Phe Ser 
            260                 265                 270         


Lys Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly 
        275                 280                 285             


Asp Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala 
    290                 295                 300                 


Val Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala 
305                 310                 315                 320 


Lys Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp 
                325                 330                 335     


Leu Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr 
            340                 345                 350         


Arg Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile 
        355                 360                 365             


Glu Gly His Ala Thr Gln Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu 
    370                 375                 380                 


Leu Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln 
385                 390                 395                 400 


Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro 
                405                 410                 415     


His Gln Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys 
            420                 425                 430         


Lys His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu 
        435                 440                 445             


Leu Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln 
    450                 455                 460                 


Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 
465                 470                 475                 480 


Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 
                485                 490                 495     


Arg Phe Ile Glu Arg Met Asn Asn Thr Asp Met Tyr Ile Pro His Asn 
            500                 505                 510         


Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr 
        515                 520                 525             


Asn Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn 
    530                 535                 540                 


Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 
545                 550                 555                 560 


Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu 
                565                 570                 575     


Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 
            580                 585                 590         


Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 
        595                 600                 605             


Lys Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 
    610                 615                 620                 


Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 
625                 630                 635                 640 


Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 
                645                 650                 655     


Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Lys Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile 
        675                 680                 685             


Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 
    690                 695                 700                 


Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 
705                 710                 715                 720 


Ile Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 
                725                 730                 735     


Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
            740                 745                 750         


Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 
        755                 760                 765             


Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg 
    770                 775                 780                 


Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 
785                 790                 795                 800 


Lys Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 
                805                 810                 815     


Ser Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
            820                 825                 830         


Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 
        835                 840                 845             


Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 
    850                 855                 860                 


Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 
865                 870                 875                 880 


Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 
                885                 890                 895     


Asp Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu 
            900                 905                 910         


Thr Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu 
    930                 935                 940                 


His His Arg Phe Asn Lys Ala Glu Asp Thr Asn Glu Pro Ile Arg Lys 
945                 950                 955                 960 


Val Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn 
                965                 970                 975     


Arg Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Gly Val  Val Ala Leu Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Gln Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Leu Lys 
    1010                 1015                 1020             


Phe Asn  Ala His Lys Ala Asn  Lys Ala Thr Val Lys  Lys Glu Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Lys Phe  Phe Glu Ser Asp Thr  Pro Val Cys 
    1040                 1045                 1050             


Asp Glu  Asn Gly Glu Ile Phe  Trp Asp Lys Ser Lys  Ser Ile Ala 
    1055                 1060                 1065             


Gln Val  Lys Lys Val Ile Asn  His His His Met Asn  Ile Val Lys 
    1070                 1075                 1080             


Lys Thr  Glu Ile Gln Lys Gly  Gly Phe Ser Lys Glu  Thr Val Glu 
    1085                 1090                 1095             


Pro Lys  Lys Asp Ser Ser Lys  Leu Leu Pro Arg Lys  Asn Asn Trp 
    1100                 1105                 1110             


Asp Pro  Ala Lys Tyr Gly Gly  Leu Gly Ser Pro Asn  Val Ala Tyr 
    1115                 1120                 1125             


Thr Val  Ala Phe Thr Tyr Glu  Lys Gly Lys Ala Arg  Lys Arg Thr 
    1130                 1135                 1140             


Asn Ala  Leu Glu Gly Ile Thr  Ile Met Glu Arg Glu  Ala Phe Glu 
    1145                 1150                 1155             


Gln Ser  Pro Val Leu Phe Leu  Lys Asn Lys Gly Tyr  Glu Gln Ala 
    1160                 1165                 1170             


Glu Ile  Glu Met Lys Leu Pro  Lys Tyr Ala Leu Phe  Glu Leu Glu 
    1175                 1180                 1185             


Asn Gly  Arg Lys Arg Met Val  Ala Ser Asn Lys Glu  Ala Gln Lys 
    1190                 1195                 1200             


Ala Asn  Ser Phe Leu Leu Pro  Glu His Leu Val Thr  Leu Leu Tyr 
    1205                 1210                 1215             


His Ala  Lys Gln Tyr Asp Glu  Ile Ser His Lys Glu  Ser Phe Asp 
    1220                 1225                 1230             


Tyr Val  Asn Glu His His Lys  Glu Phe Ser Glu Val  Phe Ala Arg 
    1235                 1240                 1245             


Val Leu  Glu Phe Ala Gly Lys  Tyr Thr Leu Ala Glu  Lys Asn Ile 
    1250                 1255                 1260             


Glu Lys  Leu Glu Lys Ile Tyr  Lys Glu Asn Gln Thr  Asp Asp Leu 
    1265                 1270                 1275             


Ala Lys  Leu Ala Ser Ser Phe  Val Asn Leu Met Gln  Phe Asn Ala 
    1280                 1285                 1290             


Met Gly  Ala Pro Ala Asp Phe  Lys Phe Phe Asp Val  Thr Ile Pro 
    1295                 1300                 1305             


Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile Trp Gln  Ser Thr Ile 
    1310                 1315                 1320             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Arg Met 
    1325                 1330                 1335             


Gly Lys  
    1340 


<210> 206
<211> 1340
<212> PRT
<213> Enterococcus faecium


<220>
<223> Enterococcus faecium TX1337RF

<400> 206
Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Asp Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Glu Ala Lys Leu Gln Phe Ser 
            260                 265                 270         


Lys Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly 
        275                 280                 285             


Asp Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala 
    290                 295                 300                 


Val Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala 
305                 310                 315                 320 


Lys Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp 
                325                 330                 335     


Leu Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr 
            340                 345                 350         


Arg Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile 
        355                 360                 365             


Glu Gly His Ala Thr Gln Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu 
    370                 375                 380                 


Leu Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln 
385                 390                 395                 400 


Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro 
                405                 410                 415     


His Gln Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys 
            420                 425                 430         


Lys His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu 
        435                 440                 445             


Leu Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln 
    450                 455                 460                 


Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 
465                 470                 475                 480 


Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 
                485                 490                 495     


Arg Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Met Pro His Asn 
            500                 505                 510         


Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr 
        515                 520                 525             


Asn Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn 
    530                 535                 540                 


Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 
545                 550                 555                 560 


Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu 
                565                 570                 575     


Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 
            580                 585                 590         


Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 
        595                 600                 605             


Lys Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 
    610                 615                 620                 


Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 
625                 630                 635                 640 


Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 
                645                 650                 655     


Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Lys Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile 
        675                 680                 685             


Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 
    690                 695                 700                 


Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 
705                 710                 715                 720 


Ile Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 
                725                 730                 735     


Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
            740                 745                 750         


Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 
        755                 760                 765             


Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg 
    770                 775                 780                 


Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 
785                 790                 795                 800 


Lys Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 
                805                 810                 815     


Ser Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
            820                 825                 830         


Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 
        835                 840                 845             


Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 
    850                 855                 860                 


Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 
865                 870                 875                 880 


Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 
                885                 890                 895     


Asp Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu 
            900                 905                 910         


Thr Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu 
    930                 935                 940                 


His His Arg Phe Asn Lys Ala Glu Asp Thr Asn Glu Pro Ile Arg Lys 
945                 950                 955                 960 


Val Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn 
                965                 970                 975     


Arg Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Gly Val  Val Ala Leu Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Gln Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Leu Lys 
    1010                 1015                 1020             


Phe Asn  Ala His Lys Ala Asn  Lys Ala Thr Val Lys  Lys Glu Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Lys Phe  Phe Glu Ser Asp Thr  Pro Val Cys 
    1040                 1045                 1050             


Asp Glu  Asn Gly Glu Ile Phe  Trp Asp Lys Ser Lys  Ser Ile Ala 
    1055                 1060                 1065             


Gln Val  Lys Lys Val Ile Asn  His His His Met Asn  Ile Val Lys 
    1070                 1075                 1080             


Lys Thr  Glu Ile Gln Lys Gly  Gly Phe Ser Lys Glu  Thr Val Glu 
    1085                 1090                 1095             


Pro Lys  Lys Asp Ser Ser Lys  Leu Leu Pro Arg Lys  Asn Asn Trp 
    1100                 1105                 1110             


Asp Pro  Ala Lys Tyr Gly Gly  Leu Gly Ser Pro Asn  Val Ala Tyr 
    1115                 1120                 1125             


Thr Val  Ala Phe Thr Tyr Glu  Lys Gly Lys Ala Arg  Lys Arg Thr 
    1130                 1135                 1140             


Asn Ala  Leu Glu Gly Ile Thr  Ile Met Glu Arg Glu  Ala Phe Glu 
    1145                 1150                 1155             


Gln Ser  Pro Val Leu Phe Leu  Lys Asn Lys Gly Tyr  Glu Gln Ala 
    1160                 1165                 1170             


Glu Ile  Glu Met Lys Leu Pro  Lys Tyr Ala Leu Phe  Glu Leu Glu 
    1175                 1180                 1185             


Asn Gly  Arg Lys Arg Met Val  Ala Ser Asn Lys Glu  Ala Gln Lys 
    1190                 1195                 1200             


Ala Asn  Ser Phe Leu Leu Pro  Glu His Leu Val Thr  Leu Leu Tyr 
    1205                 1210                 1215             


His Ala  Lys Gln Tyr Asp Glu  Ile Ser His Lys Glu  Ser Phe Asp 
    1220                 1225                 1230             


Tyr Val  Asn Glu His His Lys  Glu Phe Ser Glu Val  Phe Ala Arg 
    1235                 1240                 1245             


Val Leu  Glu Phe Ala Gly Lys  Tyr Thr Leu Ala Glu  Lys Asn Ile 
    1250                 1255                 1260             


Glu Lys  Leu Glu Lys Ile Tyr  Lys Glu Asn Gln Thr  Asp Asp Leu 
    1265                 1270                 1275             


Ala Lys  Leu Ala Ser Ser Phe  Val Asn Leu Met Gln  Phe Asn Ala 
    1280                 1285                 1290             


Met Gly  Ala Pro Ala Asp Phe  Lys Phe Phe Asp Val  Thr Ile Pro 
    1295                 1300                 1305             


Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile Trp Gln  Ser Thr Ile 
    1310                 1315                 1320             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Arg Met 
    1325                 1330                 1335             


Gly Lys  
    1340 


<210> 207
<211> 1336
<212> PRT
<213> Enterococcus hirae

<400> 207
Met Thr Lys Asp Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Asp Tyr Gln Leu Met Lys Arg Lys Met 
            20                  25                  30          


Ser Val His Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Ala Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Phe Arg Arg Thr 
    50                  55                  60                  


Lys Arg Thr Asn Arg Arg Arg Leu Ala Arg Arg Lys Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Leu Gln Asp Leu Phe Ala Glu Glu Leu Cys Lys Gln Asp Asp Cys 
                85                  90                  95      


Phe Phe Val Arg Leu Glu Glu Ser Phe Leu Val Pro Glu Glu Lys Gln 
            100                 105                 110         


Tyr Lys Pro Ala Ser Ile Phe Pro Thr Leu Glu Glu Glu Lys Glu Tyr 
        115                 120                 125             


Tyr Gln Lys Tyr Pro Thr Ile Tyr His Leu Arg Gln Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Glu Lys Glu Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Phe Glu Gly Asp Leu Asp Thr 
                165                 170                 175     


Glu Asn Thr Ser Ile Glu Glu Ser Phe Arg Val Phe Leu Glu Gln Tyr 
            180                 185                 190         


Ser Lys Gln Ser Asp Gln Pro Leu Ile Val His Gln Pro Val Leu Thr 
        195                 200                 205             


Ile Leu Thr Asp Lys Leu Ser Lys Thr Lys Lys Val Glu Glu Ile Leu 
    210                 215                 220                 


Lys Tyr Tyr Pro Thr Glu Lys Ile Asn Ser Phe Phe Ala Gln Cys Leu 
225                 230                 235                 240 


Lys Leu Ile Val Gly Asn Gln Ala Asn Phe Lys Arg Ile Phe Asp Leu 
                245                 250                 255     


Glu Ala Glu Val Lys Leu Gln Phe Ser Lys Glu Thr Tyr Glu Glu Asp 
            260                 265                 270         


Leu Glu Ser Leu Leu Glu Lys Ile Gly Asp Glu Tyr Leu Asp Ile Phe 
        275                 280                 285             


Leu Gln Ala Lys Lys Val His Asp Ala Ile Leu Leu Ser Glu Ile Ile 
    290                 295                 300                 


Ser Ser Thr Val Lys His Thr Lys Ala Lys Leu Ser Ser Gly Met Val 
305                 310                 315                 320 


Glu Arg Tyr Glu Arg His Lys Ala Asp Leu Ala Lys Phe Lys Gln Phe 
                325                 330                 335     


Val Lys Glu Asn Val Pro Gln Lys Ala Thr Val Phe Phe Lys Asp Thr 
            340                 345                 350         


Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Lys Gly Lys Thr Thr Gln Glu 
        355                 360                 365             


Glu Phe Tyr Lys Phe Val Lys Lys Glu Leu Ser Gly Val Val Gly Ser 
    370                 375                 380                 


Glu Pro Phe Leu Glu Lys Ile Asp Gln Glu Thr Phe Leu Leu Lys Gln 
385                 390                 395                 400 


Arg Thr Tyr Thr Asn Gly Val Ile Pro His Gln Val His Leu Ile Glu 
                405                 410                 415     


Leu Lys Ala Ile Ile Asp Gln Gln Lys Gln His Tyr Pro Phe Leu Glu 
            420                 425                 430         


Glu Ala Gly Pro Lys Ile Ile Ala Leu Phe Lys Phe Arg Ile Pro Tyr 
        435                 440                 445             


Tyr Val Gly Pro Leu Ala Lys Glu Gln Glu Ala Ser Ser Phe Ala Trp 
    450                 455                 460                 


Ile Glu Arg Lys Thr Ala Glu Lys Ile Asn Pro Trp Asn Phe Ser Glu 
465                 470                 475                 480 


Val Val Asp Ile Glu Lys Ser Ala Met Arg Phe Ile Gln Arg Met Thr 
                485                 490                 495     


Lys Gln Asp Thr Tyr Leu Pro Thr Glu Lys Val Leu Pro Lys Asn Ser 
            500                 505                 510         


Leu Leu Tyr Gln Lys Tyr Met Ile Phe Asn Glu Leu Thr Lys Val Ser 
        515                 520                 525             


Tyr Lys Asp Glu Arg Gly Val Lys Gln Tyr Phe Ser Gly Asp Glu Lys 
    530                 535                 540                 


Gln Gln Ile Phe Lys Gln Leu Phe Gln Lys Glu Arg Gly Lys Ile Thr 
545                 550                 555                 560 


Val Lys Lys Leu Gln Asn Phe Leu Tyr Thr His Tyr His Ile Glu Asn 
                565                 570                 575     


Ala Gln Ile Phe Gly Ile Glu Lys Ala Phe Asn Ala Ser Tyr Ser Thr 
            580                 585                 590         


Tyr His Asp Phe Met Lys Leu Ala Lys Thr Asn Gln Lys Ala Met Gln 
        595                 600                 605             


Glu Trp Leu Glu Gln Pro Glu Met Glu Pro Ile Phe Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Met Ile Lys His Gln Leu 
625                 630                 635                 640 


Ser Lys Tyr Gln Glu Val Phe Gly Glu Lys Leu Leu Lys Glu Phe Ala 
                645                 650                 655     


Arg Lys His Tyr Thr Gly Trp Gly Arg Phe Ser Ala Lys Leu Ile His 
            660                 665                 670         


Gly Ile Arg Asp Arg Lys Thr Asn Lys Thr Ile Leu Asp Tyr Leu Ile 
        675                 680                 685             


Asn Asp Asp Asp Val Pro Ala Asn Arg Asn Arg Asn Leu Met Gln Leu 
    690                 695                 700                 


Ile Asn Asp Glu His Leu Ser Phe Lys Glu Glu Ile Ala Lys Ala Thr 
705                 710                 715                 720 


Val Phe Ser Lys His Lys Ser Leu Val Asp Val Ile Gln Asp Leu Pro 
                725                 730                 735     


Gly Ser Pro Ala Ile Lys Lys Gly Ile Trp Gln Ser Leu Lys Ile Val 
            740                 745                 750         


Glu Glu Leu Ile Ala Ile Ile Gly Tyr Lys Pro Lys Asn Ile Val Ile 
        755                 760                 765             


Glu Met Ala Arg Glu Asn Gln Lys Thr His Arg Thr Ser Pro Arg Leu 
    770                 775                 780                 


Lys Ala Leu Glu Asn Gly Leu Lys Gln Ile Gly Ser Thr Leu Leu Lys 
785                 790                 795                 800 


Glu Gln Pro Thr Asp Asn Lys Ala Leu Gln Lys Glu Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Pro Leu Glu 
            820                 825                 830         


Ile Glu Asn Leu His Gln Tyr Glu Val Asp His Ile Ile Pro Arg Ser 
        835                 840                 845             


Phe Ile Val Asp Asn Ser Ile Asp Asn Lys Val Leu Val Ala Ser Lys 
    850                 855                 860                 


Gln Asn Gln Lys Lys Arg Asp Asp Val Pro Lys Lys Gln Ile Val Asn 
865                 870                 875                 880 


Glu Gln Arg Ile Phe Trp Asn Gln Leu Lys Glu Ala Lys Leu Ile Ser 
                885                 890                 895     


Pro Lys Lys Tyr Ala Tyr Leu Thr Lys Ile Glu Leu Thr Pro Glu Asp 
            900                 905                 910         


Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Asn Ile Leu His Gln Ser Phe Asn Gln Glu Glu Glu 
    930                 935                 940                 


Gly Thr Asp Cys Asp Gly Val Gln Ile Ile Thr Leu Lys Ala Thr Leu 
945                 950                 955                 960 


Thr Ser Gln Phe Arg Gln Thr Phe Gly Leu Tyr Lys Val Arg Glu Ile 
                965                 970                 975     


Asn Pro His His His Ala His Asp Ala Tyr Leu Asn Gly Phe Ile Ala 
            980                 985                 990         


Asn Val Leu Leu Lys Arg Tyr Pro  Lys Leu Ala Pro Glu  Phe Val Tyr 
        995                 1000                 1005             


Gly Lys  Tyr Val Lys Tyr Ser  Leu Ala Arg Glu Asn  Lys Ala Thr 
    1010                 1015                 1020             


Ala Lys  Lys Glu Phe Tyr Ser  Asn Ile Leu Lys Phe  Leu Glu Ser 
    1025                 1030                 1035             


Asp Glu  Pro Phe Cys Asp Glu  Asn Gly Glu Ile Tyr  Trp Glu Lys 
    1040                 1045                 1050             


Ser His  His Leu Pro Arg Ile  Lys Lys Val Leu Ser  Ser His Gln 
    1055                 1060                 1065             


Val Asn  Val Val Lys Lys Val  Glu Gln Gln Lys Gly  Gly Phe Tyr 
    1070                 1075                 1080             


Lys Glu  Thr Val Asn Ser Lys  Glu Lys Pro Asp Lys  Leu Ile Glu 
    1085                 1090                 1095             


Arg Lys  Asn Asn Trp Asp Val  Thr Lys Tyr Gly Gly  Phe Gly Ser 
    1100                 1105                 1110             


Pro Val  Ile Ala Tyr Ala Ile  Ala Phe Val Tyr Ala  Lys Gly Lys 
    1115                 1120                 1125             


Thr Gln  Lys Lys Thr Arg Ala  Ile Glu Gly Ile Thr  Ile Met Glu 
    1130                 1135                 1140             


Gln Ala  Ala Phe Glu Lys Asp  Pro Thr Thr Phe Leu  Lys Glu Lys 
    1145                 1150                 1155             


Gly Phe  Pro Gln Val Thr Glu  Phe Ile Lys Leu Pro  Lys Tyr Thr 
    1160                 1165                 1170             


Leu Phe  Glu Phe Asp Asn Gly  Arg Arg Arg Phe Leu  Ala Ser His 
    1175                 1180                 1185             


Lys Glu  Ser Gln Lys Gly Asn  Pro Phe Ile Leu Ser  Asp Gln Leu 
    1190                 1195                 1200             


Val Thr  Leu Leu Tyr His Ala  Gln His Tyr Asp Lys  Ile Thr Tyr 
    1205                 1210                 1215             


Gln Glu  Ser Phe Asp Tyr Val  Asn Thr His Leu Ser  Asp Phe Ser 
    1220                 1225                 1230             


Ala Ile  Leu Thr Glu Val Leu  Ala Phe Ala Glu Lys  Tyr Thr Leu 
    1235                 1240                 1245             


Ala Asp  Lys Asn Ile Glu Arg  Ile Gln Glu Leu Tyr  Glu Glu Asn 
    1250                 1255                 1260             


Lys Tyr  Gly Glu Thr Ser Met  Ile Ala Gln Ser Phe  Leu Gln Leu 
    1265                 1270                 1275             


Leu Gln  Phe Asn Ala Ile Gly  Ala Pro Ala Asp Phe  Lys Phe Phe 
    1280                 1285                 1290             


Gly Val  Thr Ile Pro Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile 
    1295                 1300                 1305             


Trp Asp  Ala Thr Ile Ile Tyr  Gln Ser Val Thr Gly  Leu Tyr Glu 
    1310                 1315                 1320             


Thr Arg  Ile Arg Met Gly Asp  Leu Trp Ala Gly Glu  Gln 
    1325                 1330                 1335     


<210> 208
<211> 1330
<212> PRT
<213> Enterococcus italicus


<220>
<223> Enterococcus italicus DSM 15952

<400> 208
Met Lys Asn Asp Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ser Val Val Thr Asp Asp Tyr Lys Val Ile Ser Lys Lys Met 
            20                  25                  30          


Asn Val Phe Gly Asn Thr Glu Lys Lys Ser Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Ser Gly Gln Thr Ala Gln Glu Ala Arg Met 
    50                  55                  60                  


Lys Arg Thr Ser Arg Arg Arg Ile Ala Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Gln Pro Glu Met Asn His Leu Asp Asn Asn 
                85                  90                  95      


Phe Phe Tyr Arg Leu Asn Glu Ser Phe Leu Val Ala Asp Asp Ala Lys 
            100                 105                 110         


Tyr Asp Lys His Pro Ile Phe Gly Thr Leu Asp Glu Glu Ile His Phe 
        115                 120                 125             


His Glu Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Gly Asp Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Ile Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly Asn Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Asn Ser Val Ile Glu Leu Ser Lys Val Phe Val Gln Leu Tyr 
            180                 185                 190         


Asn Gln Thr Leu Ser Glu Leu Glu Gly Phe Gln Phe Ile Asp Glu Ser 
        195                 200                 205             


Ile Asp Phe Ser Glu Val Leu Thr Gln Gln Leu Ser Lys Ser Glu Arg 
    210                 215                 220                 


Ala Asp Asn Val Leu Lys Leu Phe Pro Asp Glu Lys Gly Thr Gly Ile 
225                 230                 235                 240 


Phe Ala Gln Phe Ile Lys Leu Ile Val Gly Asn Gln Gly Asn Phe Lys 
                245                 250                 255     


Lys Val Phe Gln Leu Glu Glu Asp Gln Lys Leu Gln Leu Ser Thr Asp 
            260                 265                 270         


Asp Tyr Glu Glu Asn Ile Glu Asn Leu Leu Ala Ile Ile Gly Asp Glu 
        275                 280                 285             


Tyr Gly Asp Ile Phe Val Ala Ala Gln Asn Leu Tyr Gln Ala Ile Leu 
    290                 295                 300                 


Leu Ala Gly Ile Leu Thr Ser Thr Glu Lys Thr Arg Ala Lys Leu Ser 
305                 310                 315                 320 


Ala Ser Met Ile Gln Arg Tyr Glu Glu His Ala Lys Asp Leu Lys Leu 
                325                 330                 335     


Leu Lys Arg Phe Val Lys Glu His Ile Pro Asp Lys Tyr Ala Glu Ile 
            340                 345                 350         


Phe Asn Asp Ala Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys 
        355                 360                 365             


Thr Lys Glu Glu Glu Phe Tyr Lys Tyr Leu Lys Thr Thr Leu Val Gln 
    370                 375                 380                 


Lys Ser Gly Tyr Gln Tyr Phe Ile Glu Lys Ile Glu Gln Glu Asn Phe 
385                 390                 395                 400 


Leu Arg Lys Gln Arg Ile Tyr Asp Asn Gly Val Ile Pro His Gln Val 
                405                 410                 415     


His Ala Glu Glu Leu Arg Ala Ile Leu Arg Lys Gln Glu Lys Tyr Tyr 
            420                 425                 430         


Ser Phe Leu Lys Glu Asn His Glu Lys Ile Glu Gln Ile Phe Lys Val 
        435                 440                 445             


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys His Asn Glu Gln Ser 
    450                 455                 460                 


Arg Phe Ala Trp Asn Ile Arg Lys Ser Asp Glu Pro Ile Arg Pro Trp 
465                 470                 475                 480 


Asn Met Asn Asp Val Val Asp Glu Asn Ala Ser Ala Val Ala Phe Ile 
                485                 490                 495     


Glu Arg Met Thr Ile Lys Asp Ile Tyr Leu Asn Glu Asn Val Leu Pro 
            500                 505                 510         


Arg His Ser Leu Ile Tyr Glu Lys Phe Thr Val Phe Asn Glu Leu Thr 
        515                 520                 525             


Lys Val Leu Tyr Ala Asp Asp Arg Gly Val Phe Gln Arg Phe Ser Ala 
    530                 535                 540                 


Glu Glu Lys Glu Asp Ile Phe Glu Lys Leu Phe Lys Ser Glu Arg Lys 
545                 550                 555                 560 


Val Thr Lys Lys Lys Leu Glu Asn Tyr Leu Arg Ile Glu Leu Ser Ile 
                565                 570                 575     


Ser Ser Pro Ser Val Lys Gly Ile Glu Glu Gln Phe Asn Ala Asn Phe 
            580                 585                 590         


Gly Thr Tyr Leu Asp Leu Lys Lys Phe Asp Glu Leu His Pro Tyr Leu 
        595                 600                 605             


Asp Asp Glu Lys Tyr Gln Asp Thr Leu Glu Glu Val Ile Lys Val Leu 
    610                 615                 620                 


Thr Val Phe Glu Asp Arg Ser Met Ile Gln Asn Gln Leu Glu Gln Leu 
625                 630                 635                 640 


Pro Leu Asn Leu Ser Thr Lys Thr Ile Lys Ala Leu Ser Arg Arg Lys 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Arg Leu Ile Asp Gly Ile His 
            660                 665                 670         


Asp Lys Asn Ser Gly Lys Thr Ile Leu Asp Tyr Leu Ile Glu Asp Glu 
        675                 680                 685             


Ser Asp Ser Tyr Ile Val Asn Arg Asn Phe Met Gln Leu Ile Asn Asp 
    690                 695                 700                 


Asp His Leu Ser Phe Lys Lys Ile Ile Glu Asp Ser Gln Pro Tyr Lys 
705                 710                 715                 720 


Glu Gln Gln Ser Ala Glu Glu Ile Val Ser Glu Leu Ser Gly Ser Pro 
                725                 730                 735     


Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu 
            740                 745                 750         


Val Ala Ile Met Gly Tyr Lys Pro Lys Asn Ile Val Val Glu Met Ala 
        755                 760                 765             


Arg Glu Asn Gln Thr Thr Gly Arg Gly Lys Gln Asn Ser Lys Pro Arg 
    770                 775                 780                 


Leu Lys Gly Ile Glu Asn Gly Leu Lys Glu Phe Ser Asp Ser Val Leu 
785                 790                 795                 800 


Lys Gly Ser Ser Ile Asp Asn Lys Gln Leu Gln Asn Asp Arg Leu Tyr 
                805                 810                 815     


Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly His Glu Leu 
            820                 825                 830         


Asp Ile Asp His Leu Ser Thr Tyr Asp Ile Asp His Ile Ile Pro Gln 
        835                 840                 845             


Ser Phe Leu Thr Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Thr Ser 
    850                 855                 860                 


Lys Ser Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val 
865                 870                 875                 880 


Arg Lys Met Asp Arg Phe Trp Arg Lys Leu Leu Asn Ala Lys Leu Ile 
                885                 890                 895     


Ser Glu Arg Lys Tyr Thr Asn Leu Thr Lys Lys Glu Leu Thr Glu Ser 
            900                 905                 910         


Asp Lys Ala Gly Phe Leu Lys Arg Gln Leu Val Glu Thr Arg Gln Ile 
        915                 920                 925             


Thr Lys His Val Ala Thr Ile Leu Asp Ser Lys Phe Asn Glu Asp Ser 
    930                 935                 940                 


Asn Asn Arg Asp Val Gln Ile Ile Thr Leu Lys Ser Ala Leu Val Ser 
945                 950                 955                 960 


Glu Phe Arg Lys Thr Phe Asn Leu Tyr Lys Val Arg Glu Ile Asn Asp 
                965                 970                 975     


Leu His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Ala Leu Ser 
            980                 985                 990         


Leu Leu Arg Val Tyr Pro Gln Leu  Lys Pro Glu Phe Val  Tyr Gly Glu 
        995                 1000                 1005             


Tyr Gly  Lys Asn Ser Ile His  Asp Gln Asn Lys Ala  Thr Ile Lys 
    1010                 1015                 1020             


Lys Gln  Phe Tyr Ser Asn Ile  Thr Arg Tyr Phe Ala  Ser Lys Asp 
    1025                 1030                 1035             


Tyr Ile  Ile Asn Asp Asp Gly  Glu Ile Leu Trp Asn  Lys Gln Glu 
    1040                 1045                 1050             


Thr Ile  Ala Gln Val Ile Lys  Thr Leu Gly Met His  Gln Val Asn 
    1055                 1060                 1065             


Val Val  Lys Lys Val Glu Ile  Gln Lys Gly Gly Phe  Ser Lys Glu 
    1070                 1075                 1080             


Ser Ile  Gln Pro Lys Gly Glu  Ser Gln Lys Leu Ile  Arg Arg Lys 
    1085                 1090                 1095             


Gln Gln  Trp Asn Thr Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Val 
    1100                 1105                 1110             


Val Ala  Tyr Ala Ile Leu Leu  Ser Phe Asp Lys Gly  Lys Arg Lys 
    1115                 1120                 1125             


Ala Arg  Ser Phe Lys Ile Val  Gly Ile Thr Ile Gln  Asp Arg Glu 
    1130                 1135                 1140             


Ser Phe  Glu Gly Asn Pro Ile  Leu Tyr Leu Ser Lys  Lys Asp Tyr 
    1145                 1150                 1155             


His Asn  Pro Lys Val Glu Ala  Ile Leu Pro Lys Tyr  Ser Leu Phe 
    1160                 1165                 1170             


Glu Phe  Glu Asn Gly Arg Arg  Arg Met Val Ala Ser  Ala Ser Glu 
    1175                 1180                 1185             


Thr Gln  Lys Gly Asn Gln Leu  Ile Ile Pro Gly His  Leu Met Glu 
    1190                 1195                 1200             


Leu Leu  Tyr His Ser Lys Lys  Ile Ile Asn Gly Lys  Asn Ser Asp 
    1205                 1210                 1215             


Ser Val  Ser Tyr Ile Gln Asn  Asn Lys Glu Lys Phe  Arg Glu Ile 
    1220                 1225                 1230             


Phe Glu  Tyr Ile Val Asp Phe  Ser Ser Lys Tyr Ile  Ser Ala Asp 
    1235                 1240                 1245             


Ala Asn  Leu Asn Lys Ile Glu  Lys Ile Phe Glu Asn  Asn Phe His 
    1250                 1255                 1260             


Lys Ala  Ser Glu Gln Glu Ile  Ala Lys Ser Phe Ile  Asn Leu Leu 
    1265                 1270                 1275             


Thr Phe  Thr Ala Met Gly Ala  Pro Ala Asp Phe Glu  Phe Phe Gly 
    1280                 1285                 1290             


Glu Lys  Ile Pro Arg Lys Arg  Tyr Val Ser Ile Ser  Glu Ile Ile 
    1295                 1300                 1305             


Asp Ala  Val Phe Ile His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr 
    1310                 1315                 1320             


Arg Val  Arg Leu Thr Glu Val  
    1325                 1330 


<210> 209
<211> 1096
<212> PRT
<213> Eubacterium dolichum


<220>
<223> Eubacterium dolichum DSM 3991

<400> 209
Met Met Glu Val Phe Met Gly Arg Leu Val Leu Gly Leu Asp Ile Gly 
1               5                   10                  15      


Ile Thr Ser Val Gly Phe Gly Ile Ile Asp Leu Asp Glu Ser Glu Ile 
            20                  25                  30          


Val Asp Tyr Gly Val Arg Leu Phe Lys Glu Gly Thr Ala Ala Glu Asn 
        35                  40                  45              


Glu Thr Arg Arg Thr Lys Arg Gly Gly Arg Arg Leu Lys Arg Arg Arg 
    50                  55                  60                  


Val Thr Arg Arg Glu Asp Met Leu His Leu Leu Lys Gln Ala Gly Ile 
65                  70                  75                  80  


Ile Ser Thr Ser Phe His Pro Leu Asn Asn Pro Tyr Asp Val Arg Val 
                85                  90                  95      


Lys Gly Leu Asn Glu Arg Leu Asn Gly Glu Glu Leu Ala Thr Ala Leu 
            100                 105                 110         


Leu His Leu Cys Lys His Arg Gly Ser Ser Val Glu Thr Ile Glu Asp 
        115                 120                 125             


Asp Glu Ala Lys Ala Lys Glu Ala Gly Glu Thr Lys Lys Val Leu Ser 
    130                 135                 140                 


Met Asn Asp Gln Leu Leu Lys Ser Gly Lys Tyr Val Cys Glu Ile Gln 
145                 150                 155                 160 


Lys Glu Arg Leu Arg Thr Asn Gly His Ile Arg Gly His Glu Asn Asn 
                165                 170                 175     


Phe Lys Thr Arg Ala Tyr Val Asp Glu Ala Phe Gln Ile Leu Ser His 
            180                 185                 190         


Gln Asp Leu Ser Asn Glu Leu Lys Ser Ala Ile Ile Thr Ile Ile Ser 
        195                 200                 205             


Arg Lys Arg Met Tyr Tyr Asp Gly Pro Gly Gly Pro Leu Ser Pro Thr 
    210                 215                 220                 


Pro Tyr Gly Arg Tyr Thr Tyr Phe Gly Gln Lys Glu Pro Ile Asp Leu 
225                 230                 235                 240 


Ile Glu Lys Met Arg Gly Lys Cys Ser Leu Phe Pro Asn Glu Pro Arg 
                245                 250                 255     


Ala Pro Lys Leu Ala Tyr Ser Ala Glu Leu Phe Asn Leu Leu Asn Asp 
            260                 265                 270         


Leu Asn Asn Leu Ser Ile Glu Gly Glu Lys Leu Thr Ser Glu Gln Lys 
        275                 280                 285             


Ala Met Ile Leu Lys Ile Val His Glu Lys Gly Lys Ile Thr Pro Lys 
    290                 295                 300                 


Gln Leu Ala Lys Glu Val Gly Val Ser Leu Glu Gln Ile Arg Gly Phe 
305                 310                 315                 320 


Arg Ile Asp Thr Lys Gly Ser Pro Leu Leu Ser Glu Leu Thr Gly Tyr 
                325                 330                 335     


Lys Met Ile Arg Glu Val Leu Glu Lys Ser Asn Asp Glu His Leu Glu 
            340                 345                 350         


Asp His Val Phe Tyr Asp Glu Ile Ala Glu Ile Leu Thr Lys Thr Lys 
        355                 360                 365             


Asp Ile Glu Gly Arg Lys Lys Gln Ile Ser Glu Leu Ser Ser Asp Leu 
    370                 375                 380                 


Asn Glu Glu Ser Val His Gln Leu Ala Gly Leu Thr Lys Phe Thr Ala 
385                 390                 395                 400 


Tyr His Ser Leu Ser Phe Lys Ala Leu Arg Leu Ile Asn Glu Glu Met 
                405                 410                 415     


Leu Lys Thr Glu Leu Asn Gln Met Gln Ser Ile Thr Leu Phe Gly Leu 
            420                 425                 430         


Lys Gln Asn Asn Glu Leu Ser Val Lys Gly Met Lys Asn Ile Gln Ala 
        435                 440                 445             


Asp Asp Thr Ala Ile Leu Ser Pro Val Ala Lys Arg Ala Gln Arg Glu 
    450                 455                 460                 


Thr Phe Lys Val Val Asn Arg Leu Arg Glu Ile Tyr Gly Glu Phe Asp 
465                 470                 475                 480 


Ser Ile Val Val Glu Met Ala Arg Glu Lys Asn Ser Glu Glu Gln Arg 
                485                 490                 495     


Lys Ala Ile Arg Glu Arg Gln Lys Phe Phe Glu Met Arg Asn Lys Gln 
            500                 505                 510         


Val Ala Asp Ile Ile Gly Asp Asp Arg Lys Ile Asn Ala Lys Leu Arg 
        515                 520                 525             


Glu Lys Leu Val Leu Tyr Gln Glu Gln Asp Gly Lys Thr Ala Tyr Ser 
    530                 535                 540                 


Leu Glu Pro Ile Asp Leu Lys Leu Leu Ile Asp Asp Pro Asn Ala Tyr 
545                 550                 555                 560 


Glu Val Asp His Ile Ile Pro Ile Ser Ile Ser Leu Asp Asp Ser Ile 
                565                 570                 575     


Thr Asn Lys Val Leu Val Thr His Arg Glu Asn Gln Glu Lys Gly Asn 
            580                 585                 590         


Leu Thr Pro Ile Ser Ala Phe Val Lys Gly Arg Phe Thr Lys Gly Ser 
        595                 600                 605             


Leu Ala Gln Tyr Lys Ala Tyr Cys Leu Lys Leu Lys Glu Lys Asn Ile 
    610                 615                 620                 


Lys Thr Asn Lys Gly Tyr Arg Lys Lys Val Glu Gln Tyr Leu Leu Asn 
625                 630                 635                 640 


Glu Asn Asp Ile Tyr Lys Tyr Asp Ile Gln Lys Glu Phe Ile Asn Arg 
                645                 650                 655     


Asn Leu Val Asp Thr Ser Tyr Ala Ser Arg Val Val Leu Asn Thr Leu 
            660                 665                 670         


Thr Thr Tyr Phe Lys Gln Asn Glu Ile Pro Thr Lys Val Phe Thr Val 
        675                 680                 685             


Lys Gly Ser Leu Thr Asn Ala Phe Arg Arg Lys Ile Asn Leu Lys Lys 
    690                 695                 700                 


Asp Arg Asp Glu Asp Tyr Gly His His Ala Ile Asp Ala Leu Ile Ile 
705                 710                 715                 720 


Ala Ser Met Pro Lys Met Arg Leu Leu Ser Thr Ile Phe Ser Arg Tyr 
                725                 730                 735     


Lys Ile Glu Asp Ile Tyr Asp Glu Ser Thr Gly Glu Val Phe Ser Ser 
            740                 745                 750         


Gly Asp Asp Ser Met Tyr Tyr Asp Asp Arg Tyr Phe Ala Phe Ile Ala 
        755                 760                 765             


Ser Leu Lys Ala Ile Lys Val Arg Lys Phe Ser His Lys Ile Asp Thr 
    770                 775                 780                 


Lys Pro Asn Arg Ser Val Ala Asp Glu Thr Ile Tyr Ser Thr Arg Val 
785                 790                 795                 800 


Ile Asp Gly Lys Glu Lys Val Val Lys Lys Tyr Lys Asp Ile Tyr Asp 
                805                 810                 815     


Pro Lys Phe Thr Ala Leu Ala Glu Asp Ile Leu Asn Asn Ala Tyr Gln 
            820                 825                 830         


Glu Lys Tyr Leu Met Ala Leu His Asp Pro Gln Thr Phe Asp Gln Ile 
        835                 840                 845             


Val Lys Val Val Asn Tyr Tyr Phe Glu Glu Met Ser Lys Ser Glu Lys 
    850                 855                 860                 


Tyr Phe Thr Lys Asp Lys Lys Gly Arg Ile Lys Ile Ser Gly Met Asn 
865                 870                 875                 880 


Pro Leu Ser Leu Tyr Arg Asp Glu His Gly Met Leu Lys Lys Tyr Ser 
                885                 890                 895     


Lys Lys Gly Asp Gly Pro Ala Ile Thr Gln Met Lys Tyr Phe Asp Gly 
            900                 905                 910         


Val Leu Gly Asn His Ile Asp Ile Ser Ala His Tyr Gln Val Arg Asp 
        915                 920                 925             


Lys Lys Val Val Leu Gln Gln Ile Ser Pro Tyr Arg Thr Asp Phe Tyr 
    930                 935                 940                 


Tyr Ser Lys Glu Asn Gly Tyr Lys Phe Val Thr Ile Arg Tyr Lys Asp 
945                 950                 955                 960 


Val Arg Trp Ser Glu Lys Lys Lys Lys Tyr Val Ile Asp Gln Gln Asp 
                965                 970                 975     


Tyr Ala Met Lys Lys Ala Glu Lys Lys Ile Asp Asp Thr Tyr Glu Phe 
            980                 985                 990         


Gln Phe Ser Met His Arg Asp Glu  Leu Ile Gly Ile Thr  Lys Ala Glu 
        995                 1000                 1005             


Gly Glu  Ala Leu Ile Tyr Pro  Asp Glu Thr Trp His  Asn Phe Asn 
    1010                 1015                 1020             


Phe Phe  Phe His Ala Gly Glu  Thr Pro Glu Ile Leu  Lys Phe Thr 
    1025                 1030                 1035             


Ala Thr  Asn Asn Asp Lys Ser  Asn Lys Ile Glu Val  Lys Pro Ile 
    1040                 1045                 1050             


His Cys  Tyr Cys Lys Met Arg  Leu Met Pro Thr Ile  Ser Lys Lys 
    1055                 1060                 1065             


Ile Val  Arg Ile Asp Lys Tyr  Ala Thr Asp Val Val  Gly Asn Leu 
    1070                 1075                 1080             


Tyr Lys  Val Lys Lys Asn Thr  Leu Lys Phe Glu Phe  Asp 
    1085                 1090                 1095     


<210> 210
<211> 1114
<212> PRT
<213> Eubacterium rectale

<400> 210
Met Asn Tyr Thr Glu Lys Glu Lys Leu Phe Met Lys Tyr Ile Leu Ala 
1               5                   10                  15      


Leu Asp Ile Gly Ile Ala Ser Val Gly Trp Ala Ile Leu Asp Lys Glu 
            20                  25                  30          


Ser Glu Thr Val Ile Glu Ala Gly Ser Asn Ile Phe Pro Glu Ala Ser 
        35                  40                  45              


Ala Ala Asp Asn Gln Leu Arg Arg Asp Met Arg Gly Ala Lys Arg Asn 
    50                  55                  60                  


Asn Arg Arg Leu Lys Thr Arg Ile Asn Asp Phe Ile Lys Leu Trp Glu 
65                  70                  75                  80  


Asn Asn Asn Leu Ser Ile Pro Gln Phe Lys Ser Thr Glu Ile Val Gly 
                85                  90                  95      


Leu Lys Val Arg Ala Ile Thr Glu Glu Ile Thr Leu Asp Glu Leu Tyr 
            100                 105                 110         


Leu Ile Leu Tyr Ser Tyr Leu Lys His Arg Gly Ile Ser Tyr Leu Glu 
        115                 120                 125             


Asp Ala Leu Asp Asp Thr Val Ser Gly Ser Ser Ala Tyr Ala Asn Gly 
    130                 135                 140                 


Leu Lys Leu Asn Ala Lys Glu Leu Glu Thr His Tyr Pro Cys Glu Ile 
145                 150                 155                 160 


Gln Gln Glu Arg Leu Asn Thr Ile Gly Lys Tyr Arg Gly Gln Ser Gln 
                165                 170                 175     


Ile Ile Asn Glu Asn Gly Glu Val Leu Asp Leu Ser Asn Val Phe Thr 
            180                 185                 190         


Ile Gly Ala Tyr Arg Lys Glu Ile Gln Arg Val Phe Glu Ile Gln Lys 
        195                 200                 205             


Lys Tyr His Pro Glu Leu Thr Asp Glu Phe Cys Asp Gly Tyr Met Leu 
    210                 215                 220                 


Ile Phe Asn Arg Lys Arg Lys Tyr Tyr Glu Gly Pro Gly Asn Glu Lys 
225                 230                 235                 240 


Ser Arg Thr Asp Tyr Gly Arg Phe Thr Thr Lys Leu Asp Ala Asn Gly 
                245                 250                 255     


Asn Tyr Ile Thr Glu Asp Asn Ile Phe Glu Lys Leu Ile Gly Lys Cys 
            260                 265                 270         


Ser Val Tyr Pro Asp Glu Leu Arg Ala Ala Ala Ala Ser Tyr Thr Ala 
        275                 280                 285             


Gln Glu Tyr Asn Val Leu Asn Asp Leu Asn Asn Leu Thr Ile Asn Gly 
    290                 295                 300                 


Arg Lys Leu Glu Glu Asn Glu Lys His Glu Ile Val Glu Arg Ile Lys 
305                 310                 315                 320 


Ser Ser Asn Thr Ile Asn Met Arg Lys Ile Ile Ser Asp Cys Met Gly 
                325                 330                 335     


Glu Asn Ile Asp Asp Phe Ala Gly Ala Arg Ile Asp Lys Ser Gly Lys 
            340                 345                 350         


Glu Ile Phe His Lys Phe Glu Val Tyr Asn Lys Met Arg Lys Ala Leu 
        355                 360                 365             


Leu Glu Ile Gly Ile Asp Ile Ser Asn Tyr Ser Arg Glu Glu Leu Asp 
    370                 375                 380                 


Glu Ile Gly Tyr Ile Met Thr Ile Asn Thr Asp Lys Glu Ala Met Met 
385                 390                 395                 400 


Glu Ala Phe Gln Lys Ser Trp Ile Asp Leu Ser Asp Asp Val Lys Gln 
                405                 410                 415     


Cys Leu Ile Asn Met Arg Lys Thr Asn Gly Ala Leu Phe Asn Lys Trp 
            420                 425                 430         


Gln Ser Phe Ser Leu Lys Ile Met Asn Glu Leu Ile Pro Glu Met Tyr 
        435                 440                 445             


Ala Gln Pro Lys Glu Gln Met Thr Leu Leu Thr Glu Met Gly Val Thr 
    450                 455                 460                 


Lys Gly Thr Gln Glu Glu Phe Ala Gly Leu Lys Tyr Ile Pro Val Asp 
465                 470                 475                 480 


Val Val Ser Glu Asp Ile Phe Asn Pro Val Val Arg Arg Ser Val Arg 
                485                 490                 495     


Ile Ser Phe Lys Ile Leu Asn Ala Val Leu Lys Lys Tyr Lys Ala Leu 
            500                 505                 510         


Asp Thr Ile Val Ile Glu Met Pro Arg Asp Arg Asn Ser Glu Glu Gln 
        515                 520                 525             


Lys Lys Arg Ile Asn Asp Ser Gln Lys Leu Asn Glu Lys Glu Met Glu 
    530                 535                 540                 


Tyr Ile Glu Lys Lys Leu Ala Val Thr Tyr Gly Ile Lys Leu Ser Pro 
545                 550                 555                 560 


Ser Asp Phe Ser Ser Gln Lys Gln Leu Ser Leu Lys Leu Lys Leu Trp 
                565                 570                 575     


Asn Glu Gln Asp Gly Ile Cys Leu Tyr Ser Gly Lys Thr Ile Asp Pro 
            580                 585                 590         


Asn Asp Ile Ile Asn Asn Pro Gln Leu Phe Glu Ile Asp His Ile Ile 
        595                 600                 605             


Pro Arg Ser Ile Ser Phe Asp Asp Ala Arg Ser Asn Lys Val Leu Val 
    610                 615                 620                 


Tyr Arg Ser Glu Asn Gln Lys Lys Gly Asn Gln Thr Pro Tyr Tyr Tyr 
625                 630                 635                 640 


Leu Thr His Ser His Ser Glu Trp Ser Phe Glu Gln Tyr Lys Ala Thr 
                645                 650                 655     


Val Met Asn Leu Ser Lys Lys Lys Glu Tyr Ala Ile Ser Arg Lys Lys 
            660                 665                 670         


Ile Gln Asn Leu Leu Tyr Ser Glu Asp Ile Thr Lys Met Asp Val Leu 
        675                 680                 685             


Lys Gly Phe Ile Asn Arg Asn Ile Asn Asp Thr Ser Tyr Ala Ser Arg 
    690                 695                 700                 


Leu Val Leu Asn Thr Ile Gln Asn Phe Phe Met Ala Asn Glu Ala Asp 
705                 710                 715                 720 


Thr Lys Val Lys Val Ile Lys Gly Ser Tyr Thr His Gln Met Arg Cys 
                725                 730                 735     


Asn Leu Lys Leu Asp Lys Asn Arg Asp Glu Ser Tyr Ser His His Ala 
            740                 745                 750         


Val Asp Ala Met Leu Ile Gly Tyr Ser Glu Leu Gly Tyr Glu Ala Tyr 
        755                 760                 765             


His Lys Leu Gln Gly Glu Phe Ile Asp Phe Glu Thr Gly Glu Ile Leu 
    770                 775                 780                 


Arg Lys Asp Met Trp Asp Glu Asn Met Ser Asp Glu Val Tyr Ala Asp 
785                 790                 795                 800 


Tyr Leu Tyr Gly Lys Lys Trp Ala Asn Ile Arg Asn Glu Val Val Lys 
                805                 810                 815     


Ala Glu Lys Asn Val Lys Tyr Trp His Tyr Val Met Arg Lys Ser Asn 
            820                 825                 830         


Arg Gly Leu Cys Asn Gln Thr Ile Arg Gly Thr Arg Glu Tyr Asp Gly 
        835                 840                 845             


Lys Gln Tyr Lys Ile Asn Lys Leu Asp Ile Arg Thr Lys Glu Gly Ile 
    850                 855                 860                 


Lys Val Phe Ala Lys Leu Ala Phe Ser Lys Lys Asp Ser Asp Arg Glu 
865                 870                 875                 880 


Arg Leu Leu Val Tyr Leu Asn Asp Arg Arg Thr Phe Asp Asp Leu Cys 
                885                 890                 895     


Lys Ile Tyr Glu Asp Tyr Ser Asp Ala Ala Asn Pro Phe Val Gln Tyr 
            900                 905                 910         


Glu Lys Glu Thr Gly Asp Ile Ile Arg Lys Tyr Ser Lys Lys His Asn 
        915                 920                 925             


Gly Pro Arg Ile Asp Lys Leu Lys Tyr Lys Asp Gly Glu Val Gly Ala 
    930                 935                 940                 


Cys Ile Asp Ile Ser His Lys Tyr Gly Phe Glu Lys Gly Ser Lys Lys 
945                 950                 955                 960 


Val Ile Leu Glu Ser Leu Val Pro Tyr Arg Met Asp Val Tyr Tyr Lys 
                965                 970                 975     


Glu Glu Asn His Ser Tyr Tyr Leu Val Gly Val Lys Gln Ser Asp Ile 
            980                 985                 990         


Lys Phe Glu Lys Gly Arg Asn Val  Ile Asp Glu Glu Ala  Tyr Ala Arg 
        995                 1000                 1005             


Ile Leu  Val Asn Glu Lys Met  Ile Gln Pro Gly Gln  Ser Arg Ala 
    1010                 1015                 1020             


Asp Leu  Glu Asn Leu Gly Phe  Lys Phe Lys Leu Ser  Phe Tyr Lys 
    1025                 1030                 1035             


Asn Asp  Ile Ile Glu Tyr Glu  Lys Asp Gly Lys Ile  Tyr Thr Glu 
    1040                 1045                 1050             


Arg Leu  Val Ser Arg Thr Met  Pro Lys Gln Arg Asn  Tyr Ile Glu 
    1055                 1060                 1065             


Thr Lys  Pro Ile Asp Lys Ala  Lys Phe Glu Lys Gln  Asn Leu Val 
    1070                 1075                 1080             


Gly Leu  Gly Lys Thr Lys Phe  Ile Lys Lys Tyr Arg  Tyr Asp Ile 
    1085                 1090                 1095             


Leu Gly  Asn Lys Tyr Ser Cys  Ser Glu Glu Lys Phe  Thr Ser Phe 
    1100                 1105                 1110             


Cys 
    


<210> 211
<211> 1391
<212> PRT
<213> Eubacterium sp.


<220>
<223> Eubacterium sp. AS15

<400> 211
Met Glu Asn Lys Gln Tyr Tyr Ile Gly Leu Asp Val Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Thr Asp Thr Ser Tyr Asn Leu Leu Arg Ala Lys 
            20                  25                  30          


Gly Lys Asp Met Trp Gly Ala Arg Leu Phe Asp Glu Ala Lys Thr Ala 
        35                  40                  45              


Val Glu Arg Arg Thr Lys Arg Thr Ser Arg Arg Arg Ser Glu Arg Glu 
    50                  55                  60                  


Lys Ala Arg Lys Ala Met Leu Lys Glu Leu Phe Ala Asp Glu Ile Asn 
65                  70                  75                  80  


Lys Val Asp Pro Asn Phe Phe Ile Arg Leu Glu Glu Ser Lys Phe Phe 
                85                  90                  95      


Leu Asp Asp Arg Ser Glu Asn Asn Arg Gln Arg Tyr Thr Leu Phe Asn 
            100                 105                 110         


Asp Ala Lys Phe Thr Asp Lys Asp Tyr Tyr Glu Lys Tyr Lys Thr Ile 
        115                 120                 125             


Phe His Leu Arg Ser Ala Leu Ile Asn Ser Asp Glu Lys Phe Asp Val 
    130                 135                 140                 


Arg Leu Val Phe Leu Ala Ile Leu Asn Leu Phe Ser His Arg Gly His 
145                 150                 155                 160 


Phe Leu Asn Ala Ser Leu Lys Gly Asp Gly Glu Ile Gln Gly Val Asp 
                165                 170                 175     


Ile Phe Tyr Asn Asp Leu Tyr Glu Val Cys Glu Glu Phe Glu Ile Asp 
            180                 185                 190         


Leu Pro Gln Ile Ser Asn Ile Asp Asn Phe Glu Lys Ile Leu Ser Gln 
        195                 200                 205             


Lys Gly Lys Ser Arg Thr Lys Ile Leu Glu Glu Leu Ser Glu Glu Leu 
    210                 215                 220                 


Ser Ile Ser Lys Lys Glu Lys Ile Lys Tyr Ser Leu Leu Lys Leu Ile 
225                 230                 235                 240 


Cys Gly Met Lys Ile Lys Val Val Asp Ile Tyr Ala Asp Glu Asp Ile 
                245                 250                 255     


Gln Glu Asp Asp Lys Lys Lys Asp Leu Gly Phe Arg Glu Ser Asp Tyr 
            260                 265                 270         


Glu Lys Ser Ser Leu Glu Val Lys Glu Ile Ile Gly Asp Asp His Phe 
        275                 280                 285             


Glu Leu Ile Glu Arg Ala Lys Ala Val His Asp Ile Gly Leu Leu Ala 
    290                 295                 300                 


Asn Ile Ile Gly Asn Ser Lys Tyr Leu Cys Glu Ala Arg Val Glu Ala 
305                 310                 315                 320 


Tyr Asp Asn His His Lys Asp Leu Gln Lys Ile Lys Glu Leu Leu Lys 
                325                 330                 335     


Lys Tyr Asp Ile Lys Ala Tyr Thr Asp Met Phe Arg Lys Met Thr Asp 
            340                 345                 350         


Lys Asn Tyr Ser Ala Tyr Val Gly Ser Val Asn Ser Asn Ile Ala Lys 
        355                 360                 365             


Glu Arg Arg Ser Val Asp Asn Arg Lys Ile Glu Asp Leu Tyr Glu Tyr 
    370                 375                 380                 


Ile Lys Lys Ile Ala Leu Lys Asn Ile Ser Asp Asp Asn Glu Asp Lys 
385                 390                 395                 400 


Ile Glu Ile Leu Lys Lys Ile Glu Thr Gly Glu Phe Leu Lys Lys Gln 
                405                 410                 415     


Leu Thr Ala Ser Asn Gly Val Ile Pro Asn Gln Leu Gln Ser Arg Glu 
            420                 425                 430         


Leu Arg Ala Ile Leu Lys Lys Ala Glu Asn Tyr Leu Pro Phe Leu Lys 
        435                 440                 445             


Glu Lys Gly Glu Lys Asn Leu Thr Val Ser Glu Met Ile Ile Gln Leu 
    450                 455                 460                 


Phe Glu Phe Gln Ile Pro Tyr Tyr Val Gly Pro Leu Asp Lys Asn Pro 
465                 470                 475                 480 


Lys Lys Asp Lys Asn Ala Asn Ser Trp Ala Val Ile Pro Ser Gly Gly 
                485                 490                 495     


Arg Ile Leu Pro Trp Asn Phe Glu Asp Lys Val Asp Val Lys Gly Ser 
            500                 505                 510         


Arg Lys Glu Phe Ile Glu Lys Met Val Arg Lys Cys Thr Tyr Leu Ser 
        515                 520                 525             


Glu Glu His Thr Leu Pro Lys Gln Ser Leu Leu Tyr Glu Lys Phe Met 
    530                 535                 540                 


Val Leu Asn Glu Ile Asn Asn Ile Lys Ile Asp Gly Glu Lys Ile Ser 
545                 550                 555                 560 


Val Glu Ala Lys Gln Lys Ile Tyr Asn Asp Leu Phe Met Lys Gly Lys 
                565                 570                 575     


Lys Val Ser Gln Lys Ala Ile Lys Gln Glu Leu Ile Ser Leu Asn Ile 
            580                 585                 590         


Met Ser Lys Asp Ser Val Leu Ser Gly Ile Asp Thr Val Cys Asn Ala 
        595                 600                 605             


Tyr Leu Ser Ser Ile Ala Lys Phe Arg Gly Val Phe Asp Glu Asn Val 
    610                 615                 620                 


Asn Asn Gln Ser Thr Ile Asp Met Ile Glu Asp Ile Ile Phe Leu Lys 
625                 630                 635                 640 


Thr Val Tyr Ser Asp Glu Lys Arg Phe Val Lys Glu Glu Ile Val Glu 
                645                 650                 655     


Lys Tyr Gly Asp Glu Ile Asp Lys Asp Lys Ile Lys Arg Ile Leu Gly 
            660                 665                 670         


Phe Lys Phe Ser Asn Trp Gly Asn Ile Ser Lys Ser Phe Leu Glu Leu 
        675                 680                 685             


Glu Gly Ala Asp Val Gly Thr Gly Glu Ile Arg Ser Ile Ile Gln Ser 
    690                 695                 700                 


Leu Trp Glu Thr Asn Phe Asn Leu Met Glu Leu Leu Ser Ser Arg Phe 
705                 710                 715                 720 


Thr Tyr Met Asp Glu Leu Glu Lys Arg Val Lys Lys Leu Glu Lys Pro 
                725                 730                 735     


Leu Ser Glu Trp Thr Ile Glu Asp Leu Asp Asp Met Tyr Leu Ser Ser 
            740                 745                 750         


Pro Val Lys Arg Met Ile Trp Gln Ser Met Lys Ile Val Asp Glu Ile 
        755                 760                 765             


Gln Thr Val Ile Gly Tyr Ala Pro Lys Arg Ile Phe Val Glu Met Thr 
    770                 775                 780                 


Arg Ser Glu Gly Glu Lys Val Arg Thr Lys Ser Arg Lys Asp Arg Leu 
785                 790                 795                 800 


Lys Glu Leu Tyr Ser Ala Ile Lys Glu Asp Ser Lys Gln Trp Val Lys 
                805                 810                 815     


Glu Leu Asp Ala Lys Asp Glu Ser Tyr Phe Arg Ser Lys Lys Met Tyr 
            820                 825                 830         


Leu Tyr Tyr Leu Gln Lys Gly Arg Cys Met Tyr Ser Gly Glu Val Ile 
        835                 840                 845             


Glu Leu Asp Lys Leu Met Asp Asp Asn Leu Tyr Asp Ile Asp His Ile 
    850                 855                 860                 


Tyr Pro Arg Ser Phe Val Lys Asp Asp Ser Leu Asp Asn Leu Val Leu 
865                 870                 875                 880 


Val Lys Lys Glu Ile Asn Asn Arg Lys Gln Asn Asp Pro Ile Thr Pro 
                885                 890                 895     


Gln Ile Gln Ala Ser Cys Gln Gly Phe Trp Lys Val Leu His Glu Gln 
            900                 905                 910         


Gly Phe Ile Ser Asn Glu Lys Tyr Ser Arg Leu Thr Arg Lys Thr Gln 
        915                 920                 925             


Glu Phe Ser Asp Glu Glu Lys Leu Ser Phe Ile Asn Arg Gln Ile Val 
    930                 935                 940                 


Glu Thr Gly Gln Ala Thr Lys Cys Met Ala Gln Ile Leu Gln Lys Ser 
945                 950                 955                 960 


Met Gly Glu Asp Val Asp Val Val Phe Ser Lys Ala Arg Leu Val Ser 
                965                 970                 975     


Glu Phe Arg His Lys Phe Glu Leu Phe Lys Ser Arg Leu Ile Asn Asp 
            980                 985                 990         


Phe His His Ala Asn Asp Ala Tyr  Leu Asn Ile Val Val  Gly Asn Ser 
        995                 1000                 1005             


Tyr Phe  Val Lys Phe Thr Arg  Asn Pro Ala Asn Phe  Ile Lys Asp 
    1010                 1015                 1020             


Ala Arg  Lys Asn Pro Asp Asn  Pro Ala Tyr Lys Tyr  His Met Asp 
    1025                 1030                 1035             


Arg Phe  Phe Glu Arg Asp Val  Lys Ser Lys Ser Glu  Val Ala Trp 
    1040                 1045                 1050             


Ile Gly  Gln Ser Glu Gly Asn  Ala Gly Thr Ile Ala  Ile Val Lys 
    1055                 1060                 1065             


Lys Thr  Met Ser Lys Asn Ser  Pro Leu Ile Thr Lys  Lys Val Glu 
    1070                 1075                 1080             


Glu Gly  His Gly Ser Ile Thr  Lys Glu Thr Ile Val  Gly Val Lys 
    1085                 1090                 1095             


Glu Ile  Lys Phe Gly Arg Asn  Lys Val Glu Lys Ala  Asp Lys Thr 
    1100                 1105                 1110             


Pro Lys  Lys Ala Asn Leu Gln  Ala Tyr Arg Pro Ile  Lys Thr Ser 
    1115                 1120                 1125             


Asp Glu  Arg Leu Cys Asn Ile  Leu Arg Tyr Gly Gly  Arg Thr Ser 
    1130                 1135                 1140             


Ile Ser  Ile Ser Gly Tyr Cys  Leu Val Glu Tyr Val  Lys Lys Arg 
    1145                 1150                 1155             


Lys Thr  Ile Arg Ser Leu Glu  Ala Ile Pro Val Tyr  Leu Gly Arg 
    1160                 1165                 1170             


Lys Asp  Ser Leu Ser Glu Glu  Lys Leu Leu Asn Tyr  Phe Arg Tyr 
    1175                 1180                 1185             


Asn Leu  Asn Asp Gly Gly Lys  Asp Ser Val Ser Asp  Ile Arg Leu 
    1190                 1195                 1200             


Cys Leu  Pro Phe Ile Ser Thr  Asn Ser Leu Val Lys  Ile Asp Gly 
    1205                 1210                 1215             


Tyr Leu  Tyr Tyr Leu Gly Gly  Lys Asn Asp Asp Arg  Ile Gln Leu 
    1220                 1225                 1230             


Tyr Asn  Ala Tyr Gln Leu Lys  Met Lys Lys Glu Glu  Val Glu Tyr 
    1235                 1240                 1245             


Ile Arg  Lys Ile Glu Lys Ala  Val Ser Met Ser Lys  Phe Asp Glu 
    1250                 1255                 1260             


Ile Asp  Arg Glu Lys Asn Pro  Val Leu Thr Glu Glu  Lys Asn Ile 
    1265                 1270                 1275             


Glu Leu  Tyr Asn Lys Ile Gln  Asp Lys Phe Glu Asn  Thr Val Phe 
    1280                 1285                 1290             


Ser Lys  Arg Met Ser Leu Val  Lys Tyr Asn Lys Lys  Asp Leu Ser 
    1295                 1300                 1305             


Phe Gly  Asp Phe Leu Lys Asn  Lys Lys Ser Lys Phe  Glu Glu Ile 
    1310                 1315                 1320             


Asp Leu  Glu Lys Gln Cys Lys  Val Leu Tyr Asn Ile  Ile Phe Asn 
    1325                 1330                 1335             


Leu Ser  Asn Leu Lys Glu Val  Asp Leu Ser Asp Ile  Gly Gly Ser 
    1340                 1345                 1350             


Lys Ser  Thr Gly Lys Cys Arg  Cys Lys Lys Asn Ile  Thr Asn Tyr 
    1355                 1360                 1365             


Lys Glu  Phe Lys Leu Ile Gln  Gln Ser Ile Thr Gly  Leu Tyr Ser 
    1370                 1375                 1380             


Cys Glu  Lys Asp Leu Met Thr  Ile 
    1385                 1390     


<210> 212
<211> 1107
<212> PRT
<213> Eubacterium ventriosum


<220>
<223> Eubacterium ventriosum ATCC 27560

<400> 212
Met Gly Tyr Thr Val Gly Leu Asp Ile Gly Val Ala Ser Val Gly Val 
1               5                   10                  15      


Ala Val Leu Asp Glu Asn Asp Asn Ile Val Glu Ala Val Ser Asn Ile 
            20                  25                  30          


Phe Asp Glu Ala Asp Thr Ser Asn Asn Lys Val Arg Arg Thr Leu Arg 
        35                  40                  45              


Glu Gly Arg Arg Thr Lys Arg Arg Gln Lys Thr Arg Ile Glu Asp Phe 
    50                  55                  60                  


Lys Gln Leu Trp Glu Thr Ser Gly Tyr Ile Ile Pro His Lys Leu His 
65                  70                  75                  80  


Leu Asn Ile Ile Glu Leu Arg Asn Lys Gly Leu Thr Glu Leu Leu Ser 
                85                  90                  95      


Leu Asp Glu Leu Tyr Cys Val Leu Leu Ser Met Leu Lys His Arg Gly 
            100                 105                 110         


Ile Ser Tyr Leu Glu Asp Ala Asp Asp Gly Glu Lys Gly Asn Ala Tyr 
        115                 120                 125             


Lys Lys Gly Leu Ala Phe Asn Glu Lys Gln Leu Lys Glu Lys Met Pro 
    130                 135                 140                 


Cys Glu Ile Gln Leu Glu Arg Met Lys Lys Tyr Gly Lys Tyr His Gly 
145                 150                 155                 160 


Glu Phe Ile Ile Glu Ile Asn Asp Glu Lys Glu Tyr Gln Ser Asn Val 
                165                 170                 175     


Phe Thr Thr Lys Ala Tyr Lys Lys Glu Leu Glu Lys Ile Phe Glu Thr 
            180                 185                 190         


Gln Arg Cys Asn Gly Asn Lys Ile Asn Thr Lys Phe Ile Lys Lys Tyr 
        195                 200                 205             


Met Glu Ile Tyr Glu Arg Lys Arg Glu Tyr Tyr Ile Gly Pro Gly Asn 
    210                 215                 220                 


Glu Lys Ser Arg Thr Asp Tyr Gly Ile Tyr Thr Thr Arg Thr Asp Glu 
225                 230                 235                 240 


Glu Gly Asn Phe Ile Asp Glu Lys Asn Ile Phe Gly Lys Leu Ile Gly 
                245                 250                 255     


Lys Cys Ser Val Tyr Pro Glu Glu Tyr Arg Ala Ser Ser Ala Ser Tyr 
            260                 265                 270         


Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Lys Ile 
        275                 280                 285             


Asn Asn Glu Lys Leu Thr Glu Phe Gln Lys Lys Glu Ile Val Glu Ile 
    290                 295                 300                 


Ile Lys Asp Ala Ser Ser Val Asn Met Arg Lys Ile Ile Lys Lys Val 
305                 310                 315                 320 


Ile Asp Glu Asp Ile Glu Gln Tyr Ser Gly Ala Arg Ile Asp Lys Lys 
                325                 330                 335     


Gly Lys Glu Ile Tyr His Thr Phe Glu Ile Tyr Arg Lys Leu Lys Lys 
            340                 345                 350         


Glu Leu Lys Thr Ile Asn Val Asp Ile Asp Ser Phe Thr Arg Glu Glu 
        355                 360                 365             


Leu Asp Lys Thr Met Asp Ile Leu Thr Leu Asn Thr Glu Arg Glu Ser 
    370                 375                 380                 


Ile Val Lys Ala Phe Asp Glu Gln Lys Phe Val Tyr Glu Glu Asn Leu 
385                 390                 395                 400 


Ile Lys Lys Leu Ile Glu Phe Arg Lys Asn Asn Gln Arg Leu Phe Ser 
                405                 410                 415     


Gly Trp His Ser Phe Ser Tyr Lys Ala Met Leu Gln Leu Ile Pro Val 
            420                 425                 430         


Met Tyr Lys Glu Pro Lys Glu Gln Met Gln Leu Leu Thr Glu Met Asn 
        435                 440                 445             


Val Phe Lys Ser Lys Lys Glu Lys Tyr Val Asn Tyr Lys Tyr Ile Pro 
    450                 455                 460                 


Glu Asn Glu Val Val Lys Glu Ile Tyr Asn Pro Val Val Val Lys Ser 
465                 470                 475                 480 


Ile Arg Thr Thr Val Lys Ile Leu Asn Ala Leu Ile Lys Lys Tyr Gly 
                485                 490                 495     


Tyr Pro Glu Ser Val Val Ile Glu Met Pro Arg Asp Lys Asn Ser Asp 
            500                 505                 510         


Asp Glu Lys Glu Lys Ile Asp Met Asn Gln Lys Lys Asn Gln Glu Glu 
        515                 520                 525             


Tyr Glu Lys Ile Leu Asn Lys Ile Tyr Asp Glu Lys Gly Ile Glu Ile 
    530                 535                 540                 


Thr Asn Lys Asp Tyr Lys Lys Gln Lys Lys Leu Val Leu Lys Leu Lys 
545                 550                 555                 560 


Leu Trp Asn Glu Gln Glu Gly Leu Cys Leu Tyr Ser Gly Lys Lys Ile 
                565                 570                 575     


Ala Ile Glu Asp Leu Leu Asn His Pro Glu Phe Phe Glu Ile Asp His 
            580                 585                 590         


Ile Ile Pro Lys Ser Ile Ser Leu Asp Asp Ser Arg Ser Asn Lys Val 
        595                 600                 605             


Leu Val Tyr Lys Thr Glu Asn Ser Ile Lys Glu Asn Asp Thr Pro Tyr 
    610                 615                 620                 


His Tyr Leu Thr Arg Ile Asn Gly Lys Trp Gly Phe Asp Glu Tyr Lys 
625                 630                 635                 640 


Ala Asn Val Leu Glu Leu Arg Arg Arg Gly Lys Ile Asp Asp Lys Lys 
                645                 650                 655     


Val Asn Asn Leu Leu Cys Met Glu Asp Ile Thr Lys Ile Asp Val Val 
            660                 665                 670         


Lys Gly Phe Ile Asn Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg 
        675                 680                 685             


Val Val Leu Asn Glu Met Gln Ser Phe Phe Glu Ser Arg Lys Tyr Cys 
    690                 695                 700                 


Asn Thr Lys Val Lys Val Ile Arg Gly Ser Leu Thr Tyr Gln Met Arg 
705                 710                 715                 720 


Gln Asp Leu His Leu Lys Lys Asn Arg Glu Glu Ser Tyr Ser His His 
                725                 730                 735     


Ala Val Asp Ala Met Leu Ile Ala Phe Ser Gln Lys Gly Tyr Glu Ala 
            740                 745                 750         


Tyr Arg Lys Ile Gln Lys Asp Cys Tyr Asp Phe Glu Thr Gly Glu Ile 
        755                 760                 765             


Leu Asp Lys Glu Lys Trp Asn Lys Tyr Ile Asp Asp Asp Glu Phe Asp 
    770                 775                 780                 


Asp Ile Leu Tyr Lys Glu Arg Met Asn Glu Ile Arg Lys Lys Ile Ile 
785                 790                 795                 800 


Glu Ala Glu Glu Lys Val Lys Tyr Asn Tyr Lys Ile Asp Lys Lys Cys 
                805                 810                 815     


Asn Arg Gly Leu Cys Asn Gln Thr Ile Tyr Gly Thr Arg Glu Lys Asp 
            820                 825                 830         


Gly Lys Ile His Lys Ile Ser Ser Tyr Asn Ile Tyr Asp Asp Lys Glu 
        835                 840                 845             


Cys Asn Ser Leu Lys Lys Met Ile Asn Ser Gly Lys Gly Ser Asp Leu 
    850                 855                 860                 


Leu Met Tyr Asn Asn Asp Pro Lys Thr Tyr Arg Asp Met Leu Lys Ile 
865                 870                 875                 880 


Leu Glu Thr Tyr Ser Ser Glu Lys Asn Pro Phe Val Ala Tyr Asn Lys 
                885                 890                 895     


Glu Thr Gly Asp Tyr Phe Arg Lys Tyr Ser Lys Asn His Asn Gly Pro 
            900                 905                 910         


Lys Val Glu Lys Val Lys Tyr Tyr Ser Gly Gln Ile Asn Ser Cys Ile 
        915                 920                 925             


Asp Ile Ser His Lys Tyr Gly His Ala Lys Asn Ser Lys Lys Val Val 
    930                 935                 940                 


Leu Val Ser Leu Asn Pro Tyr Arg Thr Asp Val Tyr Tyr Asp Asn Asp 
945                 950                 955                 960 


Thr Gly Lys Tyr Tyr Leu Val Gly Val Lys Tyr Asn His Ile Lys Cys 
                965                 970                 975     


Val Gly Asn Lys Tyr Val Ile Asp Ser Glu Thr Tyr Asn Glu Leu Leu 
            980                 985                 990         


Arg Lys Glu Gly Val Leu Asn Ser  Asp Glu Asn Leu Glu  Asp Leu Asn 
        995                 1000                 1005             


Ser Lys  Asn Ile Thr Tyr Lys  Phe Ser Leu Tyr Lys  Asn Asp Ile 
    1010                 1015                 1020             


Ile Gln  Tyr Glu Lys Gly Gly  Glu Tyr Tyr Thr Glu  Arg Phe Leu 
    1025                 1030                 1035             


Ser Arg  Ile Lys Glu Gln Lys  Asn Leu Ile Glu Thr  Lys Pro Ile 
    1040                 1045                 1050             


Asn Lys  Pro Asn Phe Gln Arg  Lys Asn Lys Lys Gly  Glu Trp Glu 
    1055                 1060                 1065             


Asn Thr  Arg Asn Gln Ile Ala  Leu Ala Lys Thr Lys  Tyr Val Gly 
    1070                 1075                 1080             


Lys Leu  Val Thr Asp Val Leu  Gly Asn Cys Tyr Ile  Val Asn Met 
    1085                 1090                 1095             


Glu Lys  Phe Ser Leu Val Val  Asp Lys 
    1100                 1105         


<210> 213
<211> 1391
<212> PRT
<213> Eubacterium yurii


<220>
<223> Eubacterium yurii subsp. margaretiae ATCC 43715

<400> 213
Met Glu Asn Lys Gln Tyr Tyr Ile Gly Leu Asp Val Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Thr Asp Thr Ser Tyr Asn Leu Leu Arg Ala Lys 
            20                  25                  30          


Gly Lys Asp Met Trp Gly Ala Arg Leu Phe Glu Lys Ala Asn Thr Ala 
        35                  40                  45              


Ala Glu Arg Arg Thr Lys Arg Thr Ser Arg Arg Arg Ser Glu Arg Glu 
    50                  55                  60                  


Lys Ala Arg Lys Ala Met Leu Lys Glu Leu Phe Ala Asp Glu Ile Asn 
65                  70                  75                  80  


Arg Val Asp Pro Ser Phe Phe Ile Arg Leu Glu Glu Ser Lys Phe Phe 
                85                  90                  95      


Leu Asp Asp Arg Ser Glu Asn Asn Arg Gln Arg Tyr Thr Leu Phe Asn 
            100                 105                 110         


Asp Ala Thr Phe Thr Asp Lys Asp Tyr Tyr Glu Lys Tyr Lys Thr Ile 
        115                 120                 125             


Phe His Leu Arg Ser Ala Leu Ile Asn Ser Asp Glu Lys Phe Asp Val 
    130                 135                 140                 


Arg Leu Val Phe Leu Ala Ile Leu Asn Leu Phe Ser His Arg Gly His 
145                 150                 155                 160 


Phe Leu Asn Ala Ser Leu Lys Gly Asp Gly Asp Ile Gln Gly Met Asp 
                165                 170                 175     


Val Phe Tyr Asn Asp Leu Val Glu Ser Cys Glu Tyr Phe Glu Ile Glu 
            180                 185                 190         


Leu Pro Arg Ile Thr Asn Ile Asp Asn Phe Glu Lys Ile Leu Ser Gln 
        195                 200                 205             


Lys Gly Lys Ser Arg Thr Lys Ile Leu Glu Glu Leu Ser Glu Glu Leu 
    210                 215                 220                 


Ser Ile Ser Lys Lys Asp Lys Ser Lys Tyr Asn Leu Ile Lys Leu Ile 
225                 230                 235                 240 


Ser Gly Leu Glu Ala Ser Val Val Glu Leu Tyr Asn Ile Glu Asp Ile 
                245                 250                 255     


Gln Asp Glu Asn Lys Lys Ile Lys Ile Gly Phe Arg Glu Ser Asp Tyr 
            260                 265                 270         


Glu Glu Ser Ser Leu Lys Val Lys Glu Ile Ile Gly Asp Glu Tyr Phe 
        275                 280                 285             


Asp Leu Val Glu Arg Ala Lys Ser Val His Asp Met Gly Leu Leu Ser 
    290                 295                 300                 


Asn Ile Ile Gly Asn Ser Lys Tyr Leu Cys Glu Ala Arg Val Glu Ala 
305                 310                 315                 320 


Tyr Glu Asn His His Lys Asp Leu Leu Lys Ile Lys Glu Leu Leu Lys 
                325                 330                 335     


Lys Tyr Asp Lys Lys Ala Tyr Asn Asp Met Phe Arg Lys Met Thr Asp 
            340                 345                 350         


Lys Asn Tyr Ser Ala Tyr Val Gly Ser Val Asn Ser Asn Ile Ala Lys 
        355                 360                 365             


Glu Arg Arg Ser Val Asp Lys Arg Lys Ile Glu Asp Leu Tyr Lys Tyr 
    370                 375                 380                 


Ile Glu Asp Thr Ala Leu Lys Asn Ile Pro Asp Asp Asn Lys Asp Lys 
385                 390                 395                 400 


Ile Glu Ile Leu Glu Lys Ile Lys Leu Gly Glu Phe Leu Lys Lys Gln 
                405                 410                 415     


Leu Thr Ala Ser Asn Gly Val Ile Pro Asn Gln Leu Gln Ser Arg Glu 
            420                 425                 430         


Leu Arg Ala Ile Leu Lys Lys Ala Glu Asn Tyr Leu Pro Phe Leu Lys 
        435                 440                 445             


Glu Lys Gly Glu Lys Asn Leu Thr Val Ser Glu Met Ile Ile Gln Leu 
    450                 455                 460                 


Phe Glu Phe Gln Ile Pro Tyr Tyr Val Gly Pro Leu Asp Lys Asn Pro 
465                 470                 475                 480 


Lys Lys Asp Asn Lys Ala Asn Ser Trp Ala Lys Ile Lys Gln Gly Gly 
                485                 490                 495     


Arg Ile Leu Pro Trp Asn Phe Glu Asp Lys Val Asp Val Lys Gly Ser 
            500                 505                 510         


Arg Lys Glu Phe Ile Glu Lys Met Val Arg Lys Cys Thr Tyr Ile Ser 
        515                 520                 525             


Asp Glu His Thr Leu Pro Lys Gln Ser Leu Leu Tyr Glu Lys Phe Met 
    530                 535                 540                 


Val Leu Asn Glu Ile Asn Asn Ile Lys Ile Asp Gly Glu Lys Ile Ser 
545                 550                 555                 560 


Val Glu Ala Lys Gln Lys Ile Tyr Asn Asp Leu Phe Val Lys Gly Lys 
                565                 570                 575     


Lys Val Ser Gln Lys Asp Ile Lys Lys Glu Leu Ile Ser Leu Asn Ile 
            580                 585                 590         


Met Asp Lys Asp Ser Val Leu Ser Gly Thr Asp Thr Val Cys Asn Ala 
        595                 600                 605             


Tyr Leu Ser Ser Ile Gly Lys Phe Thr Gly Val Phe Lys Glu Glu Ile 
    610                 615                 620                 


Asn Lys Gln Ser Ile Val Asp Met Ile Glu Asp Ile Ile Phe Leu Lys 
625                 630                 635                 640 


Thr Val Tyr Gly Asp Glu Lys Arg Phe Val Lys Glu Glu Ile Val Glu 
                645                 650                 655     


Lys Tyr Gly Asp Glu Ile Asp Lys Asp Lys Ile Lys Arg Ile Leu Gly 
            660                 665                 670         


Phe Lys Phe Ser Asn Trp Gly Asn Leu Ser Lys Ser Phe Leu Glu Leu 
        675                 680                 685             


Glu Gly Ala Asp Val Gly Thr Gly Glu Val Arg Ser Ile Ile Gln Ser 
    690                 695                 700                 


Leu Trp Glu Thr Asn Phe Asn Leu Met Glu Leu Leu Ser Ser Arg Phe 
705                 710                 715                 720 


Thr Tyr Met Asp Glu Leu Glu Lys Arg Val Lys Lys Leu Glu Lys Pro 
                725                 730                 735     


Leu Ser Glu Trp Thr Ile Glu Asp Leu Asp Asp Met Tyr Leu Ser Ser 
            740                 745                 750         


Pro Val Lys Arg Met Ile Trp Gln Ser Met Lys Ile Val Asp Glu Ile 
        755                 760                 765             


Gln Thr Val Ile Gly Tyr Ala Pro Lys Arg Ile Phe Val Glu Met Thr 
    770                 775                 780                 


Arg Ser Glu Gly Glu Lys Val Arg Thr Lys Ser Arg Lys Asp Arg Leu 
785                 790                 795                 800 


Lys Glu Leu Tyr Asn Gly Ile Lys Glu Asp Ser Lys Gln Trp Val Lys 
                805                 810                 815     


Glu Leu Asp Ser Lys Asp Glu Ser Tyr Phe Arg Ser Lys Lys Met Tyr 
            820                 825                 830         


Leu Tyr Tyr Leu Gln Lys Gly Arg Cys Met Tyr Ser Gly Glu Val Ile 
        835                 840                 845             


Glu Leu Asp Lys Leu Met Asp Asp Asn Leu Tyr Asp Ile Asp His Ile 
    850                 855                 860                 


Tyr Pro Arg Ser Phe Val Lys Asp Asp Ser Leu Asp Asn Leu Val Leu 
865                 870                 875                 880 


Val Lys Lys Glu Ile Asn Asn Arg Lys Gln Asn Asp Pro Ile Thr Pro 
                885                 890                 895     


Gln Ile Gln Ala Ser Cys Gln Gly Phe Trp Lys Ile Leu His Asp Gln 
            900                 905                 910         


Gly Phe Met Ser Asn Glu Lys Tyr Ser Arg Leu Thr Arg Lys Thr Gln 
        915                 920                 925             


Glu Phe Ser Asp Glu Glu Lys Leu Ser Phe Ile Asn Arg Gln Ile Val 
    930                 935                 940                 


Glu Thr Gly Gln Ala Thr Lys Cys Met Ala Gln Ile Leu Gln Lys Ser 
945                 950                 955                 960 


Met Gly Glu Asp Val Asp Val Val Phe Ser Lys Ala Arg Leu Val Ser 
                965                 970                 975     


Glu Phe Arg His Lys Phe Glu Leu Phe Lys Ser Arg Leu Ile Asn Asp 
            980                 985                 990         


Phe His His Ala Asn Asp Ala Tyr  Leu Asn Ile Val Val  Gly Asn Ser 
        995                 1000                 1005             


Tyr Phe  Val Lys Phe Thr Arg  Asn Pro Ala Asn Phe  Ile Lys Asp 
    1010                 1015                 1020             


Ala Arg  Lys Asn Pro Asp Asn  Pro Val Tyr Lys Tyr  His Met Asp 
    1025                 1030                 1035             


Arg Phe  Phe Glu Arg Asp Val  Lys Ser Lys Ser Glu  Val Ala Trp 
    1040                 1045                 1050             


Ile Gly  Gln Ser Glu Gly Asn  Ser Gly Thr Ile Val  Ile Val Lys 
    1055                 1060                 1065             


Lys Thr  Met Ala Lys Asn Ser  Pro Leu Ile Thr Lys  Lys Val Glu 
    1070                 1075                 1080             


Glu Gly  His Gly Ser Ile Thr  Lys Glu Thr Ile Val  Gly Val Lys 
    1085                 1090                 1095             


Glu Ile  Lys Phe Gly Arg Asn  Lys Val Glu Lys Ala  Asp Lys Thr 
    1100                 1105                 1110             


Pro Lys  Lys Pro Asn Leu Gln  Ala Tyr Arg Pro Ile  Lys Thr Ser 
    1115                 1120                 1125             


Asp Glu  Arg Leu Cys Asn Ile  Leu Arg Tyr Gly Gly  Arg Thr Ser 
    1130                 1135                 1140             


Ile Ser  Ile Ser Gly Tyr Cys  Leu Val Glu Tyr Val  Lys Lys Arg 
    1145                 1150                 1155             


Lys Thr  Ile Arg Ser Leu Glu  Ala Ile Pro Val Tyr  Leu Gly Arg 
    1160                 1165                 1170             


Lys Asp  Ser Leu Ser Glu Glu  Lys Leu Leu Asn Tyr  Phe Arg Tyr 
    1175                 1180                 1185             


Asn Leu  Asn Asp Gly Gly Lys  Asp Ser Val Ser Asp  Ile Arg Leu 
    1190                 1195                 1200             


Cys Leu  Pro Phe Ile Ser Thr  Asn Ser Leu Val Lys  Ile Asp Gly 
    1205                 1210                 1215             


Tyr Leu  Tyr Tyr Leu Gly Gly  Lys Asn Asp Asp Arg  Ile Gln Leu 
    1220                 1225                 1230             


Tyr Asn  Ala Tyr Gln Leu Lys  Met Lys Lys Glu Glu  Val Glu Tyr 
    1235                 1240                 1245             


Ile Arg  Lys Ile Glu Lys Ala  Val Ser Met Ser Lys  Phe Asp Glu 
    1250                 1255                 1260             


Ile Asp  Arg Glu Lys Asn Pro  Val Leu Thr Glu Glu  Lys Asn Ile 
    1265                 1270                 1275             


Glu Leu  Tyr Asn Lys Ile Gln  Asp Lys Phe Glu Asn  Thr Val Phe 
    1280                 1285                 1290             


Ser Lys  Arg Met Ser Leu Val  Lys Tyr Asn Lys Lys  Asp Leu Ser 
    1295                 1300                 1305             


Phe Gly  Asp Phe Leu Lys Asn  Lys Lys Ser Lys Phe  Glu Glu Ile 
    1310                 1315                 1320             


Asp Leu  Glu Lys Gln Cys Lys  Val Leu Tyr Asn Ile  Ile Phe Asn 
    1325                 1330                 1335             


Leu Ser  Asn Leu Lys Glu Val  Asp Leu Ser Asp Ile  Gly Gly Ser 
    1340                 1345                 1350             


Lys Ser  Thr Gly Lys Cys Arg  Cys Lys Lys Asn Ile  Thr Asn Tyr 
    1355                 1360                 1365             


Lys Glu  Phe Lys Leu Ile Gln  Gln Ser Ile Thr Gly  Leu Tyr Ser 
    1370                 1375                 1380             


Cys Glu  Lys Asp Leu Met Thr  Ile 
    1385                 1390     


<210> 214
<211> 1142
<212> PRT
<213> Facklamia hominis


<220>
<223> Facklamia hominis CCUG 36813

<400> 214
Met Tyr Ser Val Gly Leu Asp Ile Gly Ile Ala Ser Cys Gly Tyr Ser 
1               5                   10                  15      


Ile Ile Asn Asp Val Asn Gly Asn Ile Val Glu Leu Gly Thr Leu Leu 
            20                  25                  30          


Phe Lys Ser Arg Asn Ser Asp Asn Asn Glu Glu Arg Arg Thr Asn Arg 
        35                  40                  45              


Gly Ser Arg Arg Leu Ile Asn Arg Arg Arg Thr Arg Leu Asp Asp Gly 
    50                  55                  60                  


Lys Lys Leu Leu Ala Glu Lys Gly Phe Lys Gln Asp Ser Lys Leu Lys 
65                  70                  75                  80  


His Val Cys Pro Tyr Glu Leu Arg Val Lys Gly Leu His Glu Lys Leu 
                85                  90                  95      


Thr Gln Gly Glu Ile Tyr Lys Val Val Leu His Ile Leu Lys Lys Arg 
            100                 105                 110         


Gly Ile Ser Tyr Leu Asp Glu Ser Asp Glu Asn Ser Ser Gly Ile Asp 
        115                 120                 125             


Gly Ala Ser Tyr Lys Asp Gln Val Asn Leu Asn Leu Asn Leu Gln Lys 
    130                 135                 140                 


Glu Leu Thr Pro Gly Gln Ile Gln Leu Lys Arg Leu Lys Glu Asn Gly 
145                 150                 155                 160 


Arg Ile Lys Ser Gly Val Thr Phe Glu Asn Gly Tyr Gln Leu Asn Val 
                165                 170                 175     


Phe Ser Val Ser Ala Tyr Ala Asn Glu Leu Asn Lys Ile Leu Thr Lys 
            180                 185                 190         


Gln Ser Glu Tyr Tyr Ser Glu Ile Asp Gln Ile Trp Ile Asp Arg Phe 
        195                 200                 205             


Thr Lys Asn Gly Tyr Arg Lys Glu Ala Gly Leu Val Tyr Arg Lys Arg 
    210                 215                 220                 


Pro Tyr Tyr Asp Gly Pro Gly Asn Glu Lys Asn Asn Ser Ile Tyr Gly 
225                 230                 235                 240 


Arg Trp Ala Asn Phe Lys Glu Asp Gly His Pro Lys Glu Asn Ile Phe 
                245                 250                 255     


Asp Gln Leu Ile Gly Leu Asp Ser Val Asp Ser Thr Gln Val Arg Ala 
            260                 265                 270         


Ser Ala Ser Thr Leu Thr Ala Gln Lys Tyr Asn Leu Leu Asn Asp Leu 
        275                 280                 285             


Asn Asn Leu Thr Ile Ile Glu Asp Asp Arg Lys Phe Thr Thr Asp Glu 
    290                 295                 300                 


Lys Val Ser Ile Ile Asn Tyr Leu Met Thr Gln Asp Ile Thr Arg Phe 
305                 310                 315                 320 


Gly Pro Lys Glu Leu Ala Lys Phe Tyr Gln Leu Glu Val Asp Gln Ile 
                325                 330                 335     


Arg Gly Trp Arg Ile Asp Asn Lys Gly Asn Pro Glu Ile His Ser Leu 
            340                 345                 350         


Lys Val Tyr Arg Asp Trp Lys Lys Ile Phe Asn Thr Ser Ser Ile Asp 
        355                 360                 365             


Leu Thr Ser Ile Gln Thr Trp Val Val Asp Glu Leu Ala Asn Val Ile 
    370                 375                 380                 


Thr Leu Asn Thr Glu Ile Pro Ser Thr Leu Ala Thr Leu Lys Ile Lys 
385                 390                 395                 400 


Ile Pro Asp Ile Asp Gln Gln Ile Leu Asn Phe Val Glu Asn Asn Phe 
                405                 410                 415     


Tyr Glu Leu Lys Lys Lys Thr Ser Lys Asn Ser Trp His Ser Phe Ser 
            420                 425                 430         


Leu Lys Thr Leu Asn Ile Leu Ile Pro Glu Leu Leu Asn Thr Ser Glu 
        435                 440                 445             


Glu Gln Asn Thr Ile Leu Glu Arg Leu Asn Leu Lys Phe Asp Leu Lys 
    450                 455                 460                 


Asn Lys Tyr Ala Glu Lys Asn Gln Ile Pro Val Lys Glu Leu Leu Glu 
465                 470                 475                 480 


Gln Ile Tyr Asn Pro Thr Val Thr Lys Ser Val His Gln Ser Ile Lys 
                485                 490                 495     


Leu Phe Asn Glu Ile Ile Glu Lys Tyr Gly Lys Asn Asn Ile Ser Tyr 
            500                 505                 510         


Val Thr Ile Glu Met Pro Arg Asp Lys Asn Asp Gln Asp Gln Lys Asp 
        515                 520                 525             


Thr Ile Lys Arg Ile Asn Lys Leu Asn Ser Glu Arg Lys Asn Asp Ser 
    530                 535                 540                 


Glu Lys Tyr Phe Leu Glu Arg Ser Gly Trp Asp Thr Ile Arg Phe Glu 
545                 550                 555                 560 


Ser Ala Leu Lys Lys Pro Arg Phe Ala Glu Lys Leu Leu Phe Tyr Tyr 
                565                 570                 575     


Glu Gln Lys Gly Lys Cys Ala Tyr Ser Gly Gln Asp Ile Leu Ala Glu 
            580                 585                 590         


Ser Leu Leu Asn Glu Ser Cys Glu Val Asp His Ile Ile Pro Leu Ser 
        595                 600                 605             


Ile Ser Phe Asp Asp Ser Ile His Asn Lys Val Leu Val Thr Ala Ser 
    610                 615                 620                 


Ser Asn Gln Glu Lys Gly Gln Arg Thr Pro Tyr Met Ala Phe Ile Asp 
625                 630                 635                 640 


Gly Ala Lys Leu Gly Gln Ser Trp Asp Asp Phe Val Ala Trp Val Asn 
                645                 650                 655     


Ser Cys Gly Phe His Arg Lys Lys Val Gln Asn Leu Leu Tyr Glu Glu 
            660                 665                 670         


Asn Ile Phe Asn Pro Asp Val Gln Arg Gly Phe Val Ser Arg Asn Leu 
        675                 680                 685             


Asn Asp Thr Arg Tyr Ala Ser Arg Ile Val Leu Asn Ala Ile Gln Ser 
    690                 695                 700                 


Phe Phe Tyr Lys Gln Lys Asp Leu Thr Lys Val Lys Val Val Asn Gly 
705                 710                 715                 720 


Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ser Ser Leu Asp Lys 
                725                 730                 735     


Asn Arg Asp Thr Tyr His His His Ala Val Asp Ala Thr Leu Cys Ala 
            740                 745                 750         


Val Thr Pro Phe Ile Asn Ile Val Lys Tyr Glu Phe Phe Glu Glu Asp 
        755                 760                 765             


Gly Ile Lys Tyr Met Val Asp Leu Thr Thr Gly Glu Lys Val Ala Tyr 
    770                 775                 780                 


Ser Asp Tyr Lys Lys Met Lys Phe Tyr Asp Lys Arg Ala Tyr Val Pro 
785                 790                 795                 800 


Ile Trp Asp Gly Phe Ile Lys Gln Leu Thr Pro Ala Asn Leu Tyr Pro 
                805                 810                 815     


Lys Ile Lys Phe Ser His Gln Val Asp Ser Lys Trp Asn Arg Lys Ile 
            820                 825                 830         


Ser Asp Ala Thr Ile Tyr Ser Thr Arg Lys Ile Val Glu Thr Lys Ile 
        835                 840                 845             


Asn Lys Lys Gly Val Ala Lys Glu Thr Val Lys Asp Ile Val Ile Asp 
    850                 855                 860                 


Lys Ile Lys Asp Ile Tyr Thr Pro Glu Gly Trp Arg Lys Phe Lys Glu 
865                 870                 875                 880 


Lys Gln Asp Lys Leu Leu Met Lys Asn Phe Asp Glu Lys Thr Tyr Asn 
                885                 890                 895     


Lys Leu Ile Lys Ile Ala Lys Glu Tyr Pro Glu Lys Lys Glu Val Gln 
            900                 905                 910         


Thr Ser Asn Gly Lys Val Ser Leu Val Glu Val Ser Pro Phe Lys Met 
        915                 920                 925             


Tyr Cys Glu Glu Gln Asn Val Pro Ala Ile Arg Lys Tyr Ser Lys Lys 
    930                 935                 940                 


Gly Asn Gly Pro Tyr Ile Arg Ser Leu Lys Phe Tyr Asp Lys Glu Leu 
945                 950                 955                 960 


Gly Lys His Ile Asn Ile Thr Lys Asp Ser Tyr Gly Asn Asp Ile Glu 
                965                 970                 975     


Arg Thr Ile Arg Asn Lys Lys Ile Ile Leu Lys Asn Gln Asn Ser Trp 
            980                 985                 990         


Arg Thr Asp Val Tyr Tyr Asn Ser  Val Asn Asn Cys Tyr  Glu Leu Leu 
        995                 1000                 1005             


Gly Ile  Lys Tyr Cys His Leu  Lys Phe Tyr Arg Gly  Lys Tyr Gly 
    1010                 1015                 1020             


Ile Pro  Lys Ser Ile Tyr Asp  Glu Leu Lys Lys Glu  Asp Glu Ile 
    1025                 1030                 1035             


Ser Ser  Glu Ser Val Phe Lys  Phe Ser Leu Tyr Arg  His Asp Arg 
    1040                 1045                 1050             


Val Arg  Phe Glu Lys Asp Gly  Glu Tyr Ile Glu Ala  Leu Phe Gly 
    1055                 1060                 1065             


Ser Lys  Asn Glu Ser Asn Lys  Asn Tyr Leu Glu Leu  Ser Pro Ile 
    1070                 1075                 1080             


Asp Lys  Asn Lys Trp Leu Ser  Lys Glu Asn Val Lys  Phe Phe Gly 
    1085                 1090                 1095             


Glu Val  Ala Ala Ser Gly Arg  Phe Ile Lys Gly Leu  Lys Pro Gly 
    1100                 1105                 1110             


Ile Lys  Val Ile Lys Gln Ser  Thr Asp Tyr Met Gly  His Val Tyr 
    1115                 1120                 1125             


Ala Ile  His Gln Glu Lys Leu  Lys Phe Val Leu Ser  Asp Ala 
    1130                 1135                 1140         


<210> 215
<211> 1512
<212> PRT
<213> Fibrobacter succinogenes

<400> 215
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Val Asn Ala Asp Glu Ile Thr Arg Asp Asp Gly Ser Arg Tyr 
            20                  25                  30          


Leu Lys Pro Asn Gly Ile Ser Ala Ala Gly Ser Arg Ile Ile Pro Met 
        35                  40                  45              


Ser Ala Asp Ile Leu Gly Asp Phe Glu Lys Gly Asn Ser Ile Ser Gln 
    50                  55                  60                  


Thr Ala Glu Arg Thr Arg Met Arg Met Ala Arg Arg Leu His Glu Arg 
65                  70                  75                  80  


Ala Leu Leu Arg Arg Glu Arg Leu Leu Arg Val Leu Asn Leu Leu Asp 
                85                  90                  95      


Phe Leu Pro Lys His Phe Ala Asp Lys Ile Asp Arg Tyr Gly Lys Phe 
            100                 105                 110         


Thr Asp Asp Ser Glu Pro Lys Leu Ala Trp Arg Lys Asn Thr Glu Gly 
        115                 120                 125             


Lys Tyr Glu Phe Ile Phe Gln Asp Ala Phe Asn Glu Met Leu Ala Glu 
    130                 135                 140                 


Phe Lys Asp Lys Gln Pro Glu Ile Val Glu Glu Gly Lys Lys Ile Pro 
145                 150                 155                 160 


Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Glu Lys Ala 
                165                 170                 175     


Leu Ser Lys Glu Glu Leu Ser Trp Ile Leu Leu Gln Phe Asn Gln Lys 
            180                 185                 190         


Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Glu Glu Ile Pro Gln Asp 
        195                 200                 205             


Lys Lys Ile Glu Tyr Leu Ala Gln Lys Val Val Lys Val Glu Ala Thr 
    210                 215                 220                 


Asp Gln Lys Lys Gly Asp Asp Val Trp Tyr Asn Val Tyr Leu Glu Asn 
225                 230                 235                 240 


Gly Met Ile Tyr Arg Arg Thr Ser Lys Ala Pro Leu Asp Trp Glu Gly 
                245                 250                 255     


Lys Val Lys Glu Phe Ile Val Thr Thr Glu Val Glu Asn Asp Gly Glu 
            260                 265                 270         


Thr Pro Lys Lys Asp Lys Glu Gly Asn Ile Lys Arg Ser Phe Arg Ala 
        275                 280                 285             


Pro Lys Glu Asp Asp Trp Thr Leu Leu Lys Lys Lys Thr Glu Ala Asp 
    290                 295                 300                 


Ile Glu Asn Ser His Lys Thr Val Gly Cys Tyr Ile Tyr Asp Ser Leu 
305                 310                 315                 320 


Leu Asn Asn Pro Lys Gln Lys Ile Ile Gly Lys Leu Val Arg Thr Val 
                325                 330                 335     


Glu Arg Lys Phe Tyr Lys Glu Glu Leu Thr Gln Ile Leu Lys Lys Gln 
            340                 345                 350         


Val Glu Leu Ile Pro Glu Leu Arg Asp Asp Asn Leu Tyr Lys Gln Cys 
        355                 360                 365             


Ile Glu Glu Leu Tyr Pro Ile Asn Glu Ala His Arg Asn Thr Ile Ala 
    370                 375                 380                 


Lys Thr Asp Phe Ala Asn Leu Phe Ile Asn Asp Ile Leu Phe Tyr Gln 
385                 390                 395                 400 


Arg Pro Leu Lys Ser Lys Lys Ser Gln Ile Asp Asn Cys Pro Tyr Glu 
                405                 410                 415     


Glu Arg Ile Phe Ile Asp Ser Lys Thr Gly Glu Lys Lys Lys Val Pro 
            420                 425                 430         


Val Lys Cys Ile Ala Lys Ser Asn Pro Leu Phe Gln Glu Phe Arg Leu 
        435                 440                 445             


Trp Gln Phe Ile Gln Asn Leu Arg Ile Tyr Gln Arg Glu Lys Glu Ile 
    450                 455                 460                 


Asp Gly Lys Leu Leu Thr Asp Ile Asp Ile Thr Ser Glu Cys Leu Lys 
465                 470                 475                 480 


Ser Glu Glu Asp Tyr Val Arg Leu Phe Asp Trp Leu Asn Asp Arg Glu 
                485                 490                 495     


Thr Ile Glu Gln Glu Asp Leu Leu Lys His Leu Phe Asn Thr Lys Lys 
            500                 505                 510         


Ser Lys Asn Lys Glu Asn Pro Tyr Arg Trp Asn Tyr Val Glu Asp Lys 
        515                 520                 525             


Val Tyr Pro Cys Asn Glu Thr Arg Ala Thr Ile Leu Lys Gly Phe Ser 
    530                 535                 540                 


Lys Cys Gly Ile Asn Ala Ser Val Leu Ser Pro Glu Leu Glu Met Ala 
545                 550                 555                 560 


Leu Trp His Ile Leu Tyr Ser Val Glu Asp Lys Lys Glu Ile Glu Thr 
                565                 570                 575     


Ala Leu Thr His Phe Ala Gln Lys Gln Gly Trp Asn Asp Asp Phe Ala 
            580                 585                 590         


Lys Val Phe Ser Lys Ala Lys Pro Phe Lys Lys Asp Tyr Gly Ser Tyr 
        595                 600                 605             


Ser Glu Lys Ala Ile Lys Lys Leu Leu Ser Leu Met Arg Met Gly Lys 
    610                 615                 620                 


Tyr Trp Asn Gln Asp Asn Ile Asp Lys Asn Thr Leu Asp Arg Ile Asp 
625                 630                 635                 640 


Lys Ile Ile Asn Gly Glu Tyr Asp Glu Lys Ile Ser Asn Arg Val Arg 
                645                 650                 655     


Asp Asn Ala Ile Asn Leu Lys Asp Ile Ser Asp Phe Arg Gly Leu Pro 
            660                 665                 670         


Val Trp Leu Ala Cys Tyr Ile Val Tyr Asp Arg His Ser Glu Ala Lys 
        675                 680                 685             


Asp Cys Thr Lys Trp Asn Ser Pro Glu Glu Ile Asp Ser Tyr Leu Lys 
    690                 695                 700                 


Lys Phe Lys Gln His Ser Leu Arg Asn Pro Ile Val Glu Gln Val Val 
705                 710                 715                 720 


Thr Glu Thr Leu Arg Thr Val Arg Asp Ile Trp Ile Gln Glu Glu Gln 
                725                 730                 735     


Ile Asp Glu Ile His Leu Glu Leu Gly Arg Asp Leu Lys Asn Pro Ala 
            740                 745                 750         


Asp Lys Arg Lys Lys Met Ser Glu Asn Ile Leu Lys Asn Glu Asn Thr 
        755                 760                 765             


Asn Leu Arg Ile Lys Ala Met Leu Met Glu Phe Met Asn Pro Ser Met 
    770                 775                 780                 


Gly Ile Glu Asn Val Arg Pro Tyr Ser Pro Ser Gln Gln Asp Ile Leu 
785                 790                 795                 800 


Arg Ile Tyr Glu Glu Asn Ala Leu Asp Asn Leu Thr Lys Asp Asp Lys 
                805                 810                 815     


Asp Phe Asp Phe Ile Ser Lys Ile Ser Lys Gln Ala Gln Pro Ser Lys 
            820                 825                 830         


Thr Asp Ile Ile Arg Tyr Lys Cys Trp Leu Glu Gln Lys Tyr Arg Ser 
        835                 840                 845             


Pro Tyr Thr Gly Lys Thr Ile Ser Leu Ser Lys Leu Phe Thr Pro Ala 
    850                 855                 860                 


Tyr Glu Ile Glu His Val Ile Pro Gln Ser Leu Tyr Phe Asp Asp Ser 
865                 870                 875                 880 


Phe Ser Asn Lys Val Ile Cys Glu Ala Glu Val Asn Lys Leu Lys Asp 
                885                 890                 895     


Arg Gln Leu Gly Tyr Lys Phe Ile Ala Glu His His Gly Glu Lys Val 
            900                 905                 910         


Gln Leu Ser Gln Gly Glu Val Val Glu Ile Leu Ser Val Asp Ala Tyr 
        915                 920                 925             


Glu Lys Phe Val Lys Glu Asn Tyr Ala Asn Asn Arg Ile Lys Met Lys 
    930                 935                 940                 


Lys Leu Leu Met Glu Ser Ile Pro Asp Glu Phe Ile Glu Arg Gln Leu 
945                 950                 955                 960 


Asn Asp Ser Arg Tyr Ile Ser Lys Val Val Lys Gly Leu Leu Ser Asn 
                965                 970                 975     


Ile Val Arg Glu Lys Ile Asp Asp Glu Asn Tyr Glu Pro Glu Ala Val 
            980                 985                 990         


Ser Lys Asn Leu Ile Ser Cys Asn  Gly Ala Ile Thr Asp  Arg Leu Lys 
        995                 1000                 1005             


Lys Asp  Trp Gly Met Asn Asp  Val Trp Asn Ser Ile  Ile Leu Pro 
    1010                 1015                 1020             


Arg Phe  Ile Arg Met Asn Gln  Ile Thr Gly Lys Asp  Cys Phe Thr 
    1025                 1030                 1035             


Thr Thr  Asn Ala Glu Gly His  Leu Ile Pro Gln Met  Pro Leu Glu 
    1040                 1045                 1050             


Leu Gln  Lys Gly Phe Asn Lys  Lys Arg Ile Asp His  Arg His His 
    1055                 1060                 1065             


Ala Met  Asp Ala Ile Val Ile  Ala Cys Thr Thr Arg  Asp His Val 
    1070                 1075                 1080             


Asn Leu  Leu Asn Asn Glu Ala  Ala His Ser Lys Phe  Asn Ala Thr 
    1085                 1090                 1095             


Arg Tyr  Gln Leu Gln Arg Lys  Leu Arg Arg Phe Glu  Lys Ala Val 
    1100                 1105                 1110             


Ile Asp  Gly Lys Glu Arg Glu  Val Ala Lys Glu Phe  Leu Lys Pro 
    1115                 1120                 1125             


Trp Asp  Ser Phe Ser Ser Asp  Ser Lys Asn Ile Leu  Glu Asn Ile 
    1130                 1135                 1140             


Ile Val  Ser Phe Lys Gln Asn  Gln Arg Val Ile Asn  Lys Thr Thr 
    1145                 1150                 1155             


Asn Ala  Phe Leu His Phe Asp  Glu Asn Gly Lys Lys  Thr Phe Ile 
    1160                 1165                 1170             


Lys Gln  Gly Lys Gly Asp Ser  Trp Ala Ile Arg Lys  Ser Met His 
    1175                 1180                 1185             


Lys Asp  Thr Val Phe Gly Glu  Ile Asn Leu Arg Lys  Val Arg Ser 
    1190                 1195                 1200             


Val Ser  Leu Asn Glu Ala Ile  Lys Val Pro Glu Arg  Val Leu Asn 
    1205                 1210                 1215             


Lys Lys  Ile Lys Glu Lys Ile  Leu Glu Leu Lys Asn  Asn Lys Ile 
    1220                 1225                 1230             


Asp Ala  Lys Asn Ile Lys Lys  Tyr Ile Glu Glu Asn  His Thr Gly 
    1235                 1240                 1245             


Gly Tyr  Gly Ile Asp Ser Ser  Lys Ile Asp Val Phe  Tyr Phe Thr 
    1250                 1255                 1260             


Lys Glu  Thr Lys Glu Arg Phe  Phe Ala Thr Arg Lys  Thr Leu Asp 
    1265                 1270                 1275             


Thr Ser  Phe Asn Gln Ala Lys  Ile Lys Asp Ser Ile  Ala Asp Ser 
    1280                 1285                 1290             


Gly Ile  Gln Lys Ile Leu Leu  Ala His Leu Lys Ser  Lys Asn Gly 
    1295                 1300                 1305             


Asp Ala  Glu Gln Ala Phe Ser  Pro Asp Gly Ile Asp  Glu Met Asn 
    1310                 1315                 1320             


Lys Asn  Ile Val Glu Leu Asn  Asn Gly Lys Phe His  Gln Pro Ile 
    1325                 1330                 1335             


Leu Lys  Val Arg Val Tyr Glu  Lys Ala Asp Lys Phe  Ala Val Gly 
    1340                 1345                 1350             


Gln Lys  Gly Asn Lys Lys Val  Lys Phe Val Glu Ala  Ala Lys Gly 
    1355                 1360                 1365             


Thr Asn  Leu Phe Phe Ala Ile  Phe Glu Lys Asp Gly  Lys Arg Ser 
    1370                 1375                 1380             


Tyr Leu  Thr Ile Pro Leu Asn  Val Met Ile Asp Cys  Gln Lys Gln 
    1385                 1390                 1395             


Tyr Gly  Asn Gln Trp Lys Asn  Asn Ile Glu Ala Tyr  Leu Lys Glu 
    1400                 1405                 1410             


Lys Glu  Leu Val Glu Lys Asp  Val Lys Leu Gln Phe  Ile Leu Ser 
    1415                 1420                 1425             


Pro Asn  Asp Leu Val Tyr Leu  Pro Thr Glu Gly Ser  Ile Asp Lys 
    1430                 1435                 1440             


Lys Arg  Ile Tyr Lys Val Val  Ser Phe Thr Asn Asn  Arg Leu Tyr 
    1445                 1450                 1455             


Ala Ile  Pro Tyr Ala Ile Ala  Lys Ser Ile Val Asp  Lys Asn Glu 
    1460                 1465                 1470             


Phe Thr  Gln Leu Asn Lys Ile  Glu Phe Thr Asp Asn  Lys Glu Ser 
    1475                 1480                 1485             


Ile Lys  Asp Ala Cys Val Pro  Val Ile Ile Asp Arg  Leu Gly Asn 
    1490                 1495                 1500             


Val Ile  Glu Phe Asn Gly Lys  Arg Leu 
    1505                 1510         


<210> 216
<211> 1365
<212> PRT
<213> Filifactor alocis

<400> 216
Met Thr Lys Glu Tyr Tyr Leu Gly Leu Asp Val Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Thr Asp Ser Gln Tyr Asn Leu Cys Lys Phe Lys Lys 
            20                  25                  30          


Lys Asp Met Trp Gly Ile Arg Leu Phe Glu Ser Ala Asn Thr Ala Lys 
        35                  40                  45              


Asp Arg Arg Leu Gln Arg Gly Asn Arg Arg Arg Leu Glu Arg Lys Lys 
    50                  55                  60                  


Gln Arg Ile Asp Leu Leu Gln Glu Ile Phe Ser Pro Glu Ile Cys Lys 
65                  70                  75                  80  


Ile Asp Pro Thr Phe Phe Ile Arg Leu Asn Glu Ser Arg Leu His Leu 
                85                  90                  95      


Glu Asp Lys Ser Asn Asp Phe Lys Tyr Pro Leu Phe Ile Glu Lys Asp 
            100                 105                 110         


Tyr Ser Asp Ile Glu Tyr Tyr Lys Glu Phe Pro Thr Ile Phe His Leu 
        115                 120                 125             


Arg Lys His Leu Ile Glu Ser Glu Glu Lys Gln Asp Ile Arg Leu Ile 
    130                 135                 140                 


Tyr Leu Ala Leu His Asn Ile Ile Lys Thr Arg Gly His Phe Leu Ile 
145                 150                 155                 160 


Asp Gly Asp Leu Gln Ser Ala Lys Gln Leu Arg Pro Ile Leu Asp Thr 
                165                 170                 175     


Phe Leu Leu Ser Leu Gln Glu Glu Gln Asn Leu Ser Val Ser Leu Ser 
            180                 185                 190         


Glu Asn Gln Lys Asp Glu Tyr Glu Glu Ile Leu Lys Asn Arg Ser Ile 
        195                 200                 205             


Ala Lys Ser Glu Lys Val Lys Lys Leu Lys Asn Leu Phe Glu Ile Ser 
    210                 215                 220                 


Asp Glu Leu Glu Lys Glu Glu Lys Lys Ala Gln Ser Ala Val Ile Glu 
225                 230                 235                 240 


Asn Phe Cys Lys Phe Ile Val Gly Asn Lys Gly Asp Val Cys Lys Phe 
                245                 250                 255     


Leu Arg Val Ser Lys Glu Glu Leu Glu Ile Asp Ser Phe Ser Phe Ser 
            260                 265                 270         


Glu Gly Lys Tyr Glu Asp Asp Ile Val Lys Asn Leu Glu Glu Lys Val 
        275                 280                 285             


Pro Glu Lys Val Tyr Leu Phe Glu Gln Met Lys Ala Met Tyr Asp Trp 
    290                 295                 300                 


Asn Ile Leu Val Asp Ile Leu Glu Thr Glu Glu Tyr Ile Ser Phe Ala 
305                 310                 315                 320 


Lys Val Lys Gln Tyr Glu Lys His Lys Thr Asn Leu Arg Leu Leu Arg 
                325                 330                 335     


Asp Ile Ile Leu Lys Tyr Cys Thr Lys Asp Glu Tyr Asn Arg Met Phe 
            340                 345                 350         


Asn Asp Glu Lys Glu Ala Gly Ser Tyr Thr Ala Tyr Val Gly Lys Leu 
        355                 360                 365             


Lys Lys Asn Asn Lys Lys Tyr Trp Ile Glu Lys Lys Arg Asn Pro Glu 
    370                 375                 380                 


Glu Phe Tyr Lys Ser Leu Gly Lys Leu Leu Asp Lys Ile Glu Pro Leu 
385                 390                 395                 400 


Lys Glu Asp Leu Glu Val Leu Thr Met Met Ile Glu Glu Cys Lys Asn 
                405                 410                 415     


His Thr Leu Leu Pro Ile Gln Lys Asn Lys Asp Asn Gly Val Ile Pro 
            420                 425                 430         


His Gln Val His Glu Val Glu Leu Lys Lys Ile Leu Glu Asn Ala Lys 
        435                 440                 445             


Lys Tyr Tyr Ser Phe Leu Thr Glu Thr Asp Lys Asp Gly Tyr Ser Val 
    450                 455                 460                 


Val Gln Lys Ile Glu Ser Ile Phe Arg Phe Arg Ile Pro Tyr Tyr Val 
465                 470                 475                 480 


Gly Pro Leu Ser Thr Arg His Gln Glu Lys Gly Ser Asn Val Trp Met 
                485                 490                 495     


Val Arg Lys Pro Gly Arg Glu Asp Arg Ile Tyr Pro Trp Asn Met Glu 
            500                 505                 510         


Glu Ile Ile Asp Phe Glu Lys Ser Asn Glu Asn Phe Ile Thr Arg Met 
        515                 520                 525             


Thr Asn Lys Cys Thr Tyr Leu Ile Gly Glu Asp Val Leu Pro Lys His 
    530                 535                 540                 


Ser Leu Leu Tyr Ser Lys Tyr Met Val Leu Asn Glu Leu Asn Asn Val 
545                 550                 555                 560 


Lys Val Arg Gly Lys Lys Leu Pro Thr Ser Leu Lys Gln Lys Val Phe 
                565                 570                 575     


Glu Asp Leu Phe Glu Asn Lys Ser Lys Val Thr Gly Lys Asn Leu Leu 
            580                 585                 590         


Glu Tyr Leu Gln Ile Gln Asp Lys Asp Ile Gln Ile Asp Asp Leu Ser 
        595                 600                 605             


Gly Phe Asp Lys Asp Phe Lys Thr Ser Leu Lys Ser Tyr Leu Asp Phe 
    610                 615                 620                 


Lys Lys Gln Ile Phe Gly Glu Glu Ile Glu Lys Glu Ser Ile Gln Asn 
625                 630                 635                 640 


Met Ile Glu Asp Ile Ile Lys Trp Ile Thr Ile Tyr Gly Asn Asp Lys 
                645                 650                 655     


Glu Met Leu Lys Arg Val Ile Arg Ala Asn Tyr Ser Asn Gln Leu Thr 
            660                 665                 670         


Glu Glu Gln Met Lys Lys Ile Thr Gly Phe Gln Tyr Ser Gly Trp Gly 
        675                 680                 685             


Asn Phe Ser Lys Met Phe Leu Lys Gly Ile Ser Gly Ser Asp Val Ser 
    690                 695                 700                 


Thr Gly Glu Thr Phe Asp Ile Ile Thr Ala Met Trp Glu Thr Asp Asn 
705                 710                 715                 720 


Asn Leu Met Gln Ile Leu Ser Lys Lys Phe Thr Phe Met Asp Asn Val 
                725                 730                 735     


Glu Asp Phe Asn Ser Gly Lys Val Gly Lys Ile Asp Lys Ile Thr Tyr 
            740                 745                 750         


Asp Ser Thr Val Lys Glu Met Phe Leu Ser Pro Glu Asn Lys Arg Ala 
        755                 760                 765             


Val Trp Gln Thr Ile Gln Val Ala Glu Glu Ile Lys Lys Val Met Gly 
    770                 775                 780                 


Cys Glu Pro Lys Lys Ile Phe Ile Glu Met Ala Arg Gly Gly Glu Lys 
785                 790                 795                 800 


Val Lys Lys Arg Thr Lys Ser Arg Lys Ala Gln Leu Leu Glu Leu Tyr 
                805                 810                 815     


Ala Ala Cys Glu Glu Asp Cys Arg Glu Leu Ile Lys Glu Ile Glu Asp 
            820                 825                 830         


Arg Asp Glu Arg Asp Phe Asn Ser Met Lys Leu Phe Leu Tyr Tyr Thr 
        835                 840                 845             


Gln Phe Gly Lys Cys Met Tyr Ser Gly Asp Asp Ile Asp Ile Asn Glu 
    850                 855                 860                 


Leu Ile Arg Gly Asn Ser Lys Trp Asp Arg Asp His Ile Tyr Pro Gln 
865                 870                 875                 880 


Ser Lys Ile Lys Asp Asp Ser Ile Asp Asn Leu Val Leu Val Asn Lys 
                885                 890                 895     


Thr Tyr Asn Ala Lys Lys Ser Asn Glu Leu Leu Ser Glu Asp Ile Gln 
            900                 905                 910         


Lys Lys Met His Ser Phe Trp Leu Ser Leu Leu Asn Lys Lys Leu Ile 
        915                 920                 925             


Thr Lys Ser Lys Tyr Asp Arg Leu Thr Arg Lys Gly Asp Phe Thr Asp 
    930                 935                 940                 


Glu Glu Leu Ser Gly Phe Ile Ala Arg Gln Leu Val Glu Thr Arg Gln 
945                 950                 955                 960 


Ser Thr Lys Ala Ile Ala Asp Ile Phe Lys Gln Ile Tyr Ser Ser Glu 
                965                 970                 975     


Val Val Tyr Val Lys Ser Ser Leu Val Ser Asp Phe Arg Lys Lys Pro 
            980                 985                 990         


Leu Asn Tyr Leu Lys Ser Arg Arg  Val Asn Asp Tyr His  His Ala Lys 
        995                 1000                 1005             


Asp Ala  Tyr Leu Asn Ile Val  Val Gly Asn Val Tyr  Asn Lys Lys 
    1010                 1015                 1020             


Phe Thr  Ser Asn Pro Ile Gln  Trp Met Lys Lys Asn  Arg Asp Thr 
    1025                 1030                 1035             


Asn Tyr  Ser Leu Asn Lys Val  Phe Glu His Asp Val  Val Ile Asn 
    1040                 1045                 1050             


Gly Glu  Val Ile Trp Glu Lys  Cys Thr Tyr His Glu  Asp Thr Asn 
    1055                 1060                 1065             


Thr Tyr  Asp Gly Gly Thr Leu  Asp Arg Ile Arg Lys  Ile Val Glu 
    1070                 1075                 1080             


Arg Asp  Asn Ile Leu Tyr Thr  Glu Tyr Ala Tyr Cys  Glu Lys Gly 
    1085                 1090                 1095             


Glu Leu  Phe Asn Ala Thr Ile  Gln Asn Lys Asn Gly  Asn Ser Thr 
    1100                 1105                 1110             


Val Ser  Leu Lys Lys Gly Leu  Asp Val Lys Lys Tyr  Gly Gly Tyr 
    1115                 1120                 1125             


Phe Ser  Ala Asn Thr Ser Tyr  Phe Ser Leu Ile Glu  Phe Glu Asp 
    1130                 1135                 1140             


Lys Lys  Gly Asp Arg Ala Arg  His Ile Ile Gly Val  Pro Ile Tyr 
    1145                 1150                 1155             


Ile Ala  Asn Met Leu Glu His  Ser Pro Ser Ala Phe  Leu Glu Tyr 
    1160                 1165                 1170             


Cys Glu  Gln Lys Gly Tyr Gln  Asn Val Arg Ile Leu  Val Glu Lys 
    1175                 1180                 1185             


Ile Lys  Lys Asn Ser Leu Leu  Ile Ile Asn Gly Tyr  Pro Leu Arg 
    1190                 1195                 1200             


Ile Arg  Gly Glu Asn Glu Val  Asp Thr Ser Phe Lys  Arg Ala Ile 
    1205                 1210                 1215             


Gln Leu  Lys Leu Asp Gln Lys  Asn Tyr Glu Leu Val  Arg Asn Ile 
    1220                 1225                 1230             


Glu Lys  Phe Leu Glu Lys Tyr  Val Glu Lys Lys Gly  Asn Tyr Pro 
    1235                 1240                 1245             


Ile Asp  Glu Asn Arg Asp His  Ile Thr His Glu Lys  Met Asn Gln 
    1250                 1255                 1260             


Leu Tyr  Glu Val Leu Leu Ser  Lys Met Lys Lys Phe  Asn Lys Lys 
    1265                 1270                 1275             


Gly Met  Ala Asp Pro Ser Asp  Arg Ile Glu Lys Ser  Lys Pro Lys 
    1280                 1285                 1290             


Phe Ile  Lys Leu Glu Asp Leu  Ile Asp Lys Ile Asn  Val Ile Asn 
    1295                 1300                 1305             


Lys Met  Leu Asn Leu Leu Arg  Cys Asp Asn Asp Thr  Lys Ala Asp 
    1310                 1315                 1320             


Leu Ser  Leu Ile Glu Leu Pro  Lys Asn Ala Gly Ser  Phe Val Val 
    1325                 1330                 1335             


Lys Lys  Asn Thr Ile Gly Lys  Ser Lys Ile Ile Leu  Val Asn Gln 
    1340                 1345                 1350             


Ser Val  Thr Gly Leu Tyr Glu  Asn Arg Arg Glu Leu  
    1355                 1360                 1365 


<210> 217
<211> 1347
<212> PRT
<213> Finegoldia magna


<220>
<223> Finegoldia magna ACS-171-V-Col3

<400> 217
Met Lys Ser Glu Lys Lys Tyr Tyr Ile Gly Leu Asp Val Gly Thr Asn 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Thr Asp Glu Phe Tyr Asn Ile Leu Arg Ala 
            20                  25                  30          


Lys Gly Lys Asp Leu Trp Gly Val Arg Leu Phe Glu Lys Ala Lys Thr 
        35                  40                  45              


Ala Ala Asp Thr Arg Thr Phe Arg Ser Gly Arg Arg Arg Asn Asp Arg 
    50                  55                  60                  


Lys Gly Met Arg Leu Gln Ile Leu Arg Glu Ile Phe Glu Asp Glu Ile 
65                  70                  75                  80  


Lys Lys Val Asp Lys Asp Phe Tyr Asp Arg Leu Asp Glu Ser Lys Phe 
                85                  90                  95      


Trp Ala Glu Asp Lys Lys Val Ser Gly Lys Tyr Ser Leu Phe Asn Asp 
            100                 105                 110         


Lys Asn Phe Ser Asp Lys Gln Tyr Phe Glu Lys Phe Pro Thr Ile Phe 
        115                 120                 125             


His Leu Arg Lys Tyr Leu Met Glu Glu His Gly Lys Val Asp Ile Arg 
    130                 135                 140                 


Tyr Tyr Phe Leu Ala Ile Asn Gln Met Met Lys Arg Arg Gly His Phe 
145                 150                 155                 160 


Leu Ile Asp Gly Gln Ile Ser His Val Thr Asp Asp Lys Pro Leu Lys 
                165                 170                 175     


Glu Gln Leu Ile Leu Leu Ile Asn Asp Leu Leu Lys Ile Glu Leu Glu 
            180                 185                 190         


Glu Glu Leu Met Asp Ser Ile Phe Glu Ile Leu Ala Asp Val Asn Glu 
        195                 200                 205             


Lys Arg Thr Asp Lys Lys Asn Asn Leu Lys Glu Leu Ile Lys Gly Gln 
    210                 215                 220                 


Asp Phe Asn Lys Gln Glu Gly Asn Ile Leu Asn Ser Ile Phe Glu Ser 
225                 230                 235                 240 


Ile Val Thr Gly Lys Ala Lys Ile Lys Asn Ile Ile Ser Asp Glu Asp 
                245                 250                 255     


Ile Leu Glu Lys Ile Lys Glu Asp Asn Lys Glu Asp Phe Val Leu Thr 
            260                 265                 270         


Gly Asp Ser Tyr Glu Glu Asn Leu Gln Tyr Phe Glu Glu Val Leu Gln 
        275                 280                 285             


Glu Asn Ile Thr Leu Phe Asn Thr Leu Lys Ser Thr Tyr Asp Phe Val 
    290                 295                 300                 


Ile Leu Gln Ser Ile Leu Lys Gly Lys Ser Thr Leu Ser Asp Ala Gln 
305                 310                 315                 320 


Val Glu Arg Tyr Asp Glu His Lys Lys Asp Leu Glu Ile Leu Lys Lys 
                325                 330                 335     


Val Ile Lys Lys Tyr Asp Glu Asp Gly Lys Leu Phe Lys Gln Val Phe 
            340                 345                 350         


Lys Glu Asp Asn Gly Asn Gly Tyr Val Ser Tyr Ile Gly Tyr Tyr Leu 
        355                 360                 365             


Asn Lys Asn Lys Lys Ile Thr Ala Lys Lys Lys Ile Ser Asn Ile Glu 
    370                 375                 380                 


Phe Thr Lys Tyr Val Lys Gly Ile Leu Glu Lys Gln Cys Asp Cys Glu 
385                 390                 395                 400 


Asp Glu Ala Val Lys Tyr Leu Leu Gly Lys Ile Glu Gln Glu Asn Phe 
                405                 410                 415     


Leu Leu Lys Gln Ile Ser Ser Ile Asn Ser Val Ile Pro His Gln Ile 
            420                 425                 430         


His Leu Phe Glu Leu Asp Lys Ile Leu Glu Asn Leu Ala Lys Asn Tyr 
        435                 440                 445             


Pro Ser Phe Asn Asn Lys Lys Glu Glu Phe Thr Lys Ile Glu Lys Ile 
    450                 455                 460                 


Arg Lys Thr Phe Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn 
465                 470                 475                 480 


Asp Tyr His Lys Asn Asn Gly Gly Asn Ala Trp Ile Phe Arg Asn Lys 
                485                 490                 495     


Gly Glu Lys Ile Arg Pro Trp Asn Phe Glu Lys Ile Val Asp Leu His 
            500                 505                 510         


Lys Ser Glu Glu Glu Phe Ile Lys Arg Met Leu Asn Gln Cys Thr Tyr 
        515                 520                 525             


Leu Pro Glu Glu Thr Val Leu Pro Lys Ser Ser Ile Leu Tyr Ser Glu 
    530                 535                 540                 


Tyr Met Val Leu Asn Glu Leu Asn Asn Leu Arg Ile Lys Gly Lys Pro 
545                 550                 555                 560 


Leu Asp Thr Asp Val Lys Leu Lys Leu Ile Glu Glu Leu Phe Lys Lys 
                565                 570                 575     


Lys Thr Lys Val Thr Leu Lys Ser Ile Arg Asp Tyr Met Ile Arg Asn 
            580                 585                 590         


Asn Phe Ala Asp Lys Glu Asp Phe Asp Asn Ser Glu Lys Asn Leu Glu 
        595                 600                 605             


Ile Val Ser Asn Met Lys Ser Tyr Ile Asp Phe Asn Asn Ile Leu Gly 
    610                 615                 620                 


Asp Lys Phe Glu Leu Glu Met Val Glu Asp Leu Ile Glu Lys Ile Thr 
625                 630                 635                 640 


Ile His Thr Gly Asn Lys Thr Leu Leu Lys Lys Tyr Ile Glu Glu Thr 
                645                 650                 655     


Tyr Pro Asp Leu Ser Ser Ser Gln Ile Gln Lys Ile Ile Asn Leu Lys 
            660                 665                 670         


Tyr Lys Asp Trp Gly Arg Leu Ser Arg Lys Leu Leu Asp Gly Ile Lys 
        675                 680                 685             


Gly Arg Asn Lys Thr Asp Asp Val Asn Thr Val Ile Asn Phe Met Arg 
    690                 695                 700                 


Asn Ser Ser Asp Asn Leu Met Gln Ile Ile Glu Gly Lys Asn Tyr Ser 
705                 710                 715                 720 


Phe Asn Glu Tyr Ile Asp Asn Leu Arg Lys Lys Tyr Ile Pro Gln Glu 
                725                 730                 735     


Ile Ser Tyr Glu Val Val Glu Asn Leu Tyr Val Ser Pro Ser Val Lys 
            740                 745                 750         


Lys Met Ile Trp Gln Val Ile Arg Val Thr Glu Glu Ile Thr Lys Val 
        755                 760                 765             


Met Gly Tyr Asp Pro Asp Lys Ile Phe Ile Glu Met Ala Lys Ser Glu 
    770                 775                 780                 


Glu Glu Lys Lys Thr Thr Ile Ser Arg Lys Asn Lys Leu Leu Asp Leu 
785                 790                 795                 800 


Tyr Lys Ala Ile Lys Lys Asp Glu Arg Asp Ser Gln Tyr Glu Lys Leu 
                805                 810                 815     


Leu Thr Gly Leu Asn Lys Leu Asp Glu Ser Glu Leu Arg Ser Lys Lys 
            820                 825                 830         


Leu Tyr Leu Tyr Tyr Thr Gln Met Gly Arg Asp Met Tyr Thr Gly Glu 
        835                 840                 845             


Lys Ile Asp Leu Asp Lys Leu Phe Asp Ser Thr His Tyr Asp Lys Asp 
    850                 855                 860                 


His Ile Ile Pro Gln Ser Met Lys Lys Asp Asp Ser Ile Ile Asn Asn 
865                 870                 875                 880 


Leu Val Leu Val Asn Lys Asn Ala Asn Gln Thr Thr Lys Gly Asn Ile 
                885                 890                 895     


Tyr Pro Val Pro Ser Ser Ile Arg Asn Asn Pro Asp Ile Tyr Asn Tyr 
            900                 905                 910         


Trp Lys Tyr Leu Met Glu Lys Glu Phe Ile Ser Lys Glu Lys Tyr Asn 
        915                 920                 925             


Arg Leu Ile Arg Asn Thr Pro Leu Thr Asn Glu Glu Leu Gly Val Phe 
    930                 935                 940                 


Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Ser Thr Lys Ala Ile Lys 
945                 950                 955                 960 


Glu Leu Phe Glu Lys Phe Tyr Gln Lys Ser Lys Ile Ile Pro Val Lys 
                965                 970                 975     


Ala Ser Leu Ala Ser Asp Leu Arg Lys Asp Met Asn Thr Leu Lys Ser 
            980                 985                 990         


Arg Glu Val Asn Asp Leu His His  Ala His Asp Ala Phe  Leu Asn Ile 
        995                 1000                 1005             


Val Ala  Gly Asp Val Trp Asn  Arg Glu Phe Thr Ser  Asn Pro Ile 
    1010                 1015                 1020             


Asn Tyr  Val Asn Glu Asn Arg  Glu Gly Asp Lys Val  Lys Tyr Ser 
    1025                 1030                 1035             


Leu Ser  Lys Tyr Phe Thr Arg  Pro Arg Lys Ser Lys  Gly Lys Val 
    1040                 1045                 1050             


Ile Trp  Thr Pro Glu Lys Gly  Arg Lys Leu Ile Val  Asp Thr Leu 
    1055                 1060                 1065             


Asn Lys  Pro Ser Val Leu Ile  Ser Asn Glu Ser His  Val Lys Lys 
    1070                 1075                 1080             


Gly Glu  Leu Phe Asn Ala Thr  Ile Ser Gly Lys Lys  Asp Tyr Lys 
    1085                 1090                 1095             


Lys Gly  Lys Ile Tyr Leu Pro  Leu Lys Lys Asp Asp  Arg Leu Lys 
    1100                 1105                 1110             


Asp Val  Ser Lys Tyr Gly Gly  Tyr Lys Ala Ile Asn  Gly Ala Phe 
    1115                 1120                 1125             


Phe Phe  Leu Val Glu His Thr  Lys Ser Lys Lys Arg  Ile Arg Ser 
    1130                 1135                 1140             


Ile Glu  Leu Phe Pro Leu His  Leu Leu Ser Lys Phe  Tyr Glu Asp 
    1145                 1150                 1155             


Lys Asn  Thr Val Leu Asp Tyr  Ala Ile Asn Val Leu  Gln Leu Gln 
    1160                 1165                 1170             


Asp Pro  Lys Ile Ile Ile Asp  Lys Ile Asn Tyr Arg  Thr Glu Ile 
    1175                 1180                 1185             


Ile Ile  Asp Asn Phe Ser Tyr  Leu Ile Ser Thr Lys  Ser Asn Asp 
    1190                 1195                 1200             


Gly Ser  Ile Thr Val Lys Pro  Asn Glu Gln Met Tyr  Trp Arg Val 
    1205                 1210                 1215             


Asp Glu  Ile Ser Asn Leu Lys  Lys Ile Glu Asn Lys  Tyr Lys Lys 
    1220                 1225                 1230             


Asp Ala  Ile Leu Thr Glu Glu  Asp Arg Lys Ile Met  Glu Ser Tyr 
    1235                 1240                 1245             


Ile Asp  Lys Ile Tyr Gln Gln  Phe Lys Ala Gly Lys  Tyr Lys Asn 
    1250                 1255                 1260             


Arg Arg  Thr Thr Asp Thr Ile  Ile Glu Lys Tyr Glu  Ile Ile Asp 
    1265                 1270                 1275             


Leu Asp  Thr Leu Asp Asn Lys  Gln Leu Tyr Gln Leu  Leu Val Ala 
    1280                 1285                 1290             


Phe Ile  Ser Leu Ser Tyr Lys  Thr Ser Asn Asn Ala  Val Asp Phe 
    1295                 1300                 1305             


Thr Val  Ile Gly Leu Gly Thr  Glu Cys Gly Lys Pro  Arg Ile Thr 
    1310                 1315                 1320             


Asn Leu  Pro Asp Asn Thr Tyr  Leu Val Tyr Lys Ser  Ile Thr Gly 
    1325                 1330                 1335             


Ile Tyr  Glu Lys Arg Ile Arg  Ile Lys 
    1340                 1345         


<210> 218
<211> 1348
<212> PRT
<213> Finegoldia magna

<400> 218
Met Lys Ser Glu Lys Lys Tyr Tyr Ile Gly Leu Asp Val Gly Thr Asn 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Thr Asp Glu Phe Tyr Asn Ile Leu Arg Ala 
            20                  25                  30          


Lys Gly Lys Asp Leu Trp Gly Val Arg Leu Phe Glu Lys Ala Asp Thr 
        35                  40                  45              


Ala Ala Asn Thr Arg Ile Phe Arg Ser Gly Arg Arg Arg Asn Asp Arg 
    50                  55                  60                  


Lys Gly Met Arg Leu Gln Ile Leu Arg Glu Ile Phe Glu Asp Glu Ile 
65                  70                  75                  80  


Lys Lys Val Asp Lys Asp Phe Tyr Asp Arg Leu Asp Glu Ser Lys Phe 
                85                  90                  95      


Trp Ala Glu Asp Lys Lys Val Ser Gly Lys Tyr Ser Leu Phe Asn Asp 
            100                 105                 110         


Lys Asn Phe Ser Asp Lys Gln Tyr Phe Glu Lys Phe Pro Thr Ile Phe 
        115                 120                 125             


His Leu Arg Lys Tyr Leu Met Glu Glu His Gly Lys Val Asp Ile Arg 
    130                 135                 140                 


Tyr Tyr Phe Leu Ala Ile Asn Gln Met Met Lys Arg Arg Gly His Phe 
145                 150                 155                 160 


Leu Ile Asp Gly Gln Ile Ser His Val Thr Asp Asp Lys Pro Leu Lys 
                165                 170                 175     


Glu Gln Leu Ile Leu Leu Ile Asn Asp Leu Leu Lys Ile Glu Leu Glu 
            180                 185                 190         


Glu Glu Leu Met Asp Ser Ile Phe Glu Ile Leu Ala Asp Val Asn Glu 
        195                 200                 205             


Lys Arg Thr Asp Lys Lys Asn Asn Leu Lys Glu Leu Ile Lys Gly Gln 
    210                 215                 220                 


Asp Phe Asn Lys Gln Glu Gly Asn Ile Leu Asn Ser Ile Phe Glu Ser 
225                 230                 235                 240 


Ile Val Thr Gly Lys Ala Lys Ile Lys Asn Ile Ile Ser Asp Glu Asp 
                245                 250                 255     


Ile Leu Glu Lys Ile Lys Glu Asp Asn Lys Glu Asp Phe Val Leu Thr 
            260                 265                 270         


Gly Asp Ser Tyr Glu Glu Asn Leu Gln Tyr Phe Glu Glu Val Leu Gln 
        275                 280                 285             


Glu Asn Ile Thr Leu Phe Asn Thr Leu Lys Ser Thr Tyr Asp Phe Leu 
    290                 295                 300                 


Ile Leu Gln Ser Ile Leu Lys Gly Lys Ser Thr Leu Ser Asp Ala Gln 
305                 310                 315                 320 


Val Glu Arg Tyr Asp Glu His Lys Lys Asp Leu Glu Ile Leu Lys Lys 
                325                 330                 335     


Val Ile Lys Lys Tyr Asp Glu Asp Gly Lys Leu Phe Lys Gln Val Phe 
            340                 345                 350         


Lys Glu Asp Asn Gly Asn Gly Tyr Val Ser Tyr Ile Gly Tyr Tyr Leu 
        355                 360                 365             


Asn Lys Asn Lys Lys Ile Thr Ala Lys Lys Lys Ile Ser Asn Ile Glu 
    370                 375                 380                 


Phe Thr Lys Tyr Val Lys Gly Ile Leu Glu Lys Gln Cys Asp Cys Glu 
385                 390                 395                 400 


Asp Glu Asp Val Lys Tyr Leu Leu Gly Lys Ile Glu Gln Glu Asn Phe 
                405                 410                 415     


Leu Leu Lys Gln Ile Ser Ser Ile Asn Ser Val Ile Pro His Gln Ile 
            420                 425                 430         


His Leu Phe Glu Leu Asp Lys Ile Leu Glu Asn Leu Ala Lys Asn Tyr 
        435                 440                 445             


Pro Ser Phe Asn Asn Lys Lys Glu Glu Phe Thr Lys Ile Glu Lys Ile 
    450                 455                 460                 


Arg Lys Thr Phe Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn 
465                 470                 475                 480 


Asp Tyr His Lys Asn Asn Gly Gly Asn Ala Trp Ile Phe Arg Asn Lys 
                485                 490                 495     


Gly Glu Lys Ile Arg Pro Trp Asn Phe Glu Lys Ile Val Asp Leu His 
            500                 505                 510         


Lys Ser Glu Glu Glu Phe Ile Lys Arg Met Leu Asn Gln Cys Thr Tyr 
        515                 520                 525             


Leu Pro Glu Glu Thr Val Leu Pro Lys Ser Ser Ile Leu Tyr Ser Glu 
    530                 535                 540                 


Tyr Met Val Leu Asn Glu Leu Asn Asn Leu Arg Ile Asn Gly Lys Pro 
545                 550                 555                 560 


Leu Asp Thr Asp Val Lys Leu Lys Leu Ile Glu Glu Leu Phe Lys Lys 
                565                 570                 575     


Lys Thr Lys Val Thr Leu Lys Ser Ile Arg Asp Tyr Met Val Arg Asn 
            580                 585                 590         


Asn Phe Ala Asp Lys Glu Asp Phe Asp Asn Ser Glu Lys Asn Leu Glu 
        595                 600                 605             


Ile Ala Ser Asn Met Lys Ser Tyr Ile Asp Phe Asn Asn Ile Leu Glu 
    610                 615                 620                 


Asp Lys Phe Asp Val Glu Met Val Glu Asp Leu Ile Glu Lys Ile Thr 
625                 630                 635                 640 


Ile His Thr Gly Asn Lys Lys Leu Leu Lys Lys Tyr Ile Glu Glu Thr 
                645                 650                 655     


Tyr Pro Asp Leu Ser Ser Ser Gln Ile Gln Lys Ile Ile Asn Leu Lys 
            660                 665                 670         


Tyr Lys Asp Trp Gly Arg Leu Ser Arg Lys Leu Leu Asp Gly Ile Lys 
        675                 680                 685             


Gly Thr Lys Lys Glu Thr Glu Lys Thr Asp Thr Val Ile Asn Phe Leu 
    690                 695                 700                 


Arg Asn Ser Ser Asp Asn Leu Met Gln Ile Ile Gly Ser Gln Asn Tyr 
705                 710                 715                 720 


Ser Phe Asn Glu Tyr Ile Asp Lys Leu Arg Lys Lys Tyr Ile Pro Gln 
                725                 730                 735     


Glu Ile Ser Tyr Glu Val Val Glu Asn Leu Tyr Val Ser Pro Ser Val 
            740                 745                 750         


Lys Lys Met Ile Trp Gln Val Ile Arg Val Thr Glu Glu Ile Thr Lys 
        755                 760                 765             


Val Met Gly Tyr Asp Pro Asp Lys Ile Phe Ile Glu Met Ala Lys Ser 
    770                 775                 780                 


Glu Glu Glu Lys Lys Thr Thr Ile Ser Arg Lys Asn Lys Leu Leu Asp 
785                 790                 795                 800 


Leu Tyr Lys Ala Ile Lys Lys Asp Glu Arg Asp Ser Gln Tyr Glu Lys 
                805                 810                 815     


Leu Leu Thr Gly Leu Asn Lys Leu Asp Asp Ser Asp Leu Arg Ser Arg 
            820                 825                 830         


Lys Leu Tyr Leu Tyr Tyr Thr Gln Met Gly Arg Asp Met Tyr Thr Gly 
        835                 840                 845             


Glu Lys Ile Asp Leu Asp Lys Leu Phe Asp Ser Thr His Tyr Asp Lys 
    850                 855                 860                 


Asp His Ile Ile Pro Gln Ser Met Lys Lys Asp Asp Ser Ile Ile Asn 
865                 870                 875                 880 


Asn Leu Val Leu Val Asn Lys Asn Ala Asn Gln Thr Thr Lys Gly Asn 
                885                 890                 895     


Ile Tyr Pro Val Pro Ser Ser Ile Arg Asn Asn Pro Lys Ile Tyr Asn 
            900                 905                 910         


Tyr Trp Lys Tyr Leu Met Glu Lys Glu Phe Ile Ser Lys Glu Lys Tyr 
        915                 920                 925             


Asn Arg Leu Ile Arg Asn Thr Pro Leu Thr Asn Glu Glu Leu Gly Gly 
    930                 935                 940                 


Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Ser Thr Lys Ala Ile 
945                 950                 955                 960 


Lys Glu Leu Phe Glu Lys Phe Tyr Gln Lys Ser Lys Ile Ile Pro Val 
                965                 970                 975     


Lys Ala Ser Leu Ala Ser Asp Leu Arg Lys Asp Met Asn Thr Leu Lys 
            980                 985                 990         


Ser Arg Glu Val Asn Asp Leu His  His Ala His Asp Ala  Phe Leu Asn 
        995                 1000                 1005             


Ile Val  Ala Gly Asp Val Trp  Asn Arg Glu Phe Thr  Ser Asn Pro 
    1010                 1015                 1020             


Ile Asn  Tyr Val Lys Glu Asn  Arg Glu Gly Asp Lys  Val Lys Tyr 
    1025                 1030                 1035             


Ser Leu  Ser Lys Asp Phe Thr  Arg Pro Arg Lys Ser  Lys Gly Lys 
    1040                 1045                 1050             


Val Ile  Trp Thr Pro Glu Lys  Gly Arg Lys Leu Ile  Val Asp Thr 
    1055                 1060                 1065             


Leu Asn  Lys Pro Ser Val Leu  Ile Ser Asn Glu Ser  His Val Lys 
    1070                 1075                 1080             


Lys Gly  Glu Leu Phe Asn Ala  Thr Ile Ala Gly Lys  Lys Asp Tyr 
    1085                 1090                 1095             


Lys Lys  Gly Lys Ile Tyr Leu  Pro Leu Lys Lys Asp  Asp Arg Leu 
    1100                 1105                 1110             


Gln Asp  Val Ser Lys Tyr Gly  Gly Tyr Lys Ala Ile  Asn Gly Ala 
    1115                 1120                 1125             


Phe Phe  Phe Leu Val Glu His  Thr Lys Ser Lys Lys  Arg Ile Arg 
    1130                 1135                 1140             


Ser Ile  Glu Leu Phe Pro Leu  His Leu Leu Ser Lys  Phe Tyr Glu 
    1145                 1150                 1155             


Asp Lys  Asn Thr Val Leu Asp  Tyr Ala Ile Asn Val  Leu Gln Leu 
    1160                 1165                 1170             


Gln Asp  Pro Lys Ile Ile Ile  Asp Lys Ile Asn Tyr  Arg Thr Glu 
    1175                 1180                 1185             


Ile Ile  Ile Asp Asn Phe Ser  Tyr Leu Ile Ser Thr  Lys Ser Asn 
    1190                 1195                 1200             


Asp Gly  Ser Ile Thr Val Lys  Pro Asn Glu Gln Met  Tyr Trp Arg 
    1205                 1210                 1215             


Val Asp  Glu Ile Ser Asn Leu  Lys Lys Ile Glu Asn  Lys Tyr Lys 
    1220                 1225                 1230             


Lys Asp  Ala Ile Leu Thr Glu  Glu Asp Arg Lys Ile  Met Glu Ser 
    1235                 1240                 1245             


Tyr Ile  Asp Lys Ile Tyr Gln  Gln Phe Lys Ala Gly  Lys Tyr Lys 
    1250                 1255                 1260             


Asn Arg  Arg Thr Thr Asp Thr  Ile Ile Glu Lys Tyr  Glu Ile Ile 
    1265                 1270                 1275             


Asp Leu  Asp Thr Leu Asp Asn  Lys Gln Leu Tyr Gln  Leu Leu Val 
    1280                 1285                 1290             


Ala Phe  Ile Ser Leu Ser Tyr  Lys Thr Ser Asn Asn  Ala Val Asp 
    1295                 1300                 1305             


Phe Thr  Val Ile Gly Leu Gly  Thr Glu Cys Gly Lys  Pro Arg Ile 
    1310                 1315                 1320             


Thr Asn  Leu Pro Asp Asn Thr  Tyr Leu Val Tyr Lys  Ser Ile Thr 
    1325                 1330                 1335             


Gly Ile  Tyr Glu Lys Arg Ile  Arg Ile Lys 
    1340                 1345             


<210> 219
<211> 1348
<212> PRT
<213> Finegoldia magna


<220>
<223> Finegoldia magna SY403409CC001050417

<400> 219
Met Lys Ser Glu Lys Lys Tyr Tyr Ile Gly Leu Asp Val Gly Thr Asn 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Thr Asp Glu Phe Tyr Asn Ile Leu Arg Ala 
            20                  25                  30          


Lys Gly Lys Asp Leu Trp Gly Val Arg Leu Phe Glu Lys Ala Lys Thr 
        35                  40                  45              


Ala Ala Asp Thr Arg Thr Phe Arg Ser Gly Arg Arg Arg Asn Asp Arg 
    50                  55                  60                  


Lys Gly Val Arg Leu Gln Ile Leu Arg Glu Ile Phe Glu Asp Glu Ile 
65                  70                  75                  80  


Lys Lys Val Asp Lys Asp Phe Tyr Asp Arg Leu Asp Glu Ser Lys Phe 
                85                  90                  95      


Trp Ala Glu Asp Lys Lys Val Ser Gly Lys Tyr Ser Leu Phe Asn Asp 
            100                 105                 110         


Lys Asn Phe Ser Asp Lys Gln Tyr Phe Glu Lys Phe Pro Thr Ile Phe 
        115                 120                 125             


His Leu Arg Lys Tyr Leu Met Glu Glu His Gly Lys Val Asp Ile Arg 
    130                 135                 140                 


Tyr Tyr Phe Leu Ala Ile Asn Gln Met Met Lys Arg Arg Gly His Phe 
145                 150                 155                 160 


Leu Ile Asp Gly Gln Ile Ser His Val Thr Asp Asp Lys Pro Leu Lys 
                165                 170                 175     


Gln Gln Leu Ile Leu Leu Ile Asn Asp Leu Leu Lys Ile Glu Leu Glu 
            180                 185                 190         


Glu Glu Phe Met Asp Ser Ile Phe Glu Ile Leu Ala Asp Val Asn Glu 
        195                 200                 205             


Lys Lys Thr Glu Lys Lys Asn Ile Leu Lys Glu Leu Ile Asn Ala Gln 
    210                 215                 220                 


Asp Phe Asn Lys Gln Glu Gly Lys Ile Leu Tyr Ser Ile Phe Glu Ser 
225                 230                 235                 240 


Ile Val Thr Gly Lys Ala Lys Ile Lys Asn Ile Ile Ser Asp Glu Asp 
                245                 250                 255     


Ile Leu Glu Lys Ile Lys Glu Asp Asn Lys Glu Asp Phe Val Leu Thr 
            260                 265                 270         


Gly Asp Ser Tyr Glu Glu Asn Leu Gln Tyr Phe Glu Glu Val Leu Gln 
        275                 280                 285             


Glu Asn Ile Thr Leu Phe Asn Thr Leu Lys Ser Ala Tyr Asp Phe Val 
    290                 295                 300                 


Ile Leu Gln Ser Ile Leu Lys Gly Lys Ser Thr Leu Ser Asp Ala Gln 
305                 310                 315                 320 


Val Glu Arg Tyr Asp Glu His Lys Lys Asp Leu Glu Ile Leu Lys Lys 
                325                 330                 335     


Val Ile Lys Lys Tyr Asp Glu Asp Gly Lys Leu Phe Lys Gln Val Phe 
            340                 345                 350         


Lys Glu Asp Asn Gly Asn Gly Tyr Val Ser Tyr Ile Gly Tyr Tyr Leu 
        355                 360                 365             


Asn Lys Asn Lys Lys Ile Thr Ala Lys Lys Lys Ile Ser Asn Ile Glu 
    370                 375                 380                 


Phe Thr Lys Tyr Val Lys Gly Ile Leu Glu Lys Gln Cys Asp Cys Glu 
385                 390                 395                 400 


Asp Glu Asp Val Lys Tyr Leu Leu Gly Lys Ile Glu Gln Glu Asn Phe 
                405                 410                 415     


Leu Leu Lys Gln Ile Ser Ser Ile Asn Ser Val Ile Pro His Gln Ile 
            420                 425                 430         


His Leu Phe Glu Leu Asp Lys Ile Leu Glu Asn Leu Ala Lys Tyr Tyr 
        435                 440                 445             


Pro Ser Phe Asn Asn Lys Lys Glu Glu Phe Thr Lys Ile Glu Lys Ile 
    450                 455                 460                 


Arg Lys Thr Phe Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn 
465                 470                 475                 480 


Asp Tyr His Lys Asn Asn Gly Gly Asn Ala Trp Ile Phe Arg Asn Lys 
                485                 490                 495     


Gly Glu Lys Ile Arg Pro Trp Asn Phe Glu Lys Ile Val Asp Leu His 
            500                 505                 510         


Lys Ser Glu Glu Glu Phe Ile Lys Arg Met Leu Asn Gln Cys Thr Tyr 
        515                 520                 525             


Leu Pro Glu Glu Thr Val Leu Pro Lys Ser Ser Ile Leu Tyr Ser Glu 
    530                 535                 540                 


Tyr Met Val Leu Asn Glu Leu Asn Asn Leu Arg Ile Asn Gly Lys Pro 
545                 550                 555                 560 


Ile Asp Thr Asp Val Lys Leu Lys Leu Ile Glu Glu Leu Phe Lys Lys 
                565                 570                 575     


Lys Thr Lys Val Thr Leu Lys Ser Ile Arg Asp Tyr Met Ile Arg Asn 
            580                 585                 590         


Asn Phe Ala Asp Lys Glu Asp Phe Asp Asn Ser Glu Lys Asn Leu Glu 
        595                 600                 605             


Ile Val Ser Asn Met Lys Ser Tyr Ile Asp Phe Asn Asn Ile Leu Gly 
    610                 615                 620                 


Asp Lys Phe Glu Leu Glu Met Val Glu Asp Leu Ile Glu Lys Ile Thr 
625                 630                 635                 640 


Ile His Thr Gly Asn Lys Lys Leu Leu Lys Lys Tyr Ile Glu Glu Thr 
                645                 650                 655     


Tyr Pro Asp Leu Ser Ser Ser Gln Ile Gln Lys Ile Ile Asn Leu Lys 
            660                 665                 670         


Tyr Lys Asp Trp Gly Arg Leu Ser Arg Lys Leu Leu Asp Gly Ile Thr 
        675                 680                 685             


Gly Thr Asn Ile Glu Thr Gly Glu Ile Asp Thr Val Ile Asn Phe Leu 
    690                 695                 700                 


Arg Asn Ser Ser Asp Asn Leu Met Gln Ile Ile Gly Ser Gln Asn Tyr 
705                 710                 715                 720 


Ser Phe Asn Asn Asp Ile Asp Lys Leu Arg Lys Lys Tyr Ile Pro Gln 
                725                 730                 735     


Glu Ile Ser Tyr Glu Val Val Glu Asn Leu Tyr Val Ser Pro Ser Val 
            740                 745                 750         


Lys Lys Met Ile Trp Gln Val Ile Arg Ile Thr Glu Glu Ile Thr Lys 
        755                 760                 765             


Val Met Gly Tyr Asp Pro Asp Lys Ile Phe Ile Glu Met Ala Lys Ser 
    770                 775                 780                 


Glu Glu Gly Lys Lys Thr Thr Ile Ser Arg Lys Asn Lys Leu Leu Ala 
785                 790                 795                 800 


Leu Tyr Lys Ala Ile Lys Lys Asp Glu Arg Asp Ser Gln Tyr Glu Lys 
                805                 810                 815     


Leu Leu Thr Gly Leu Asn Lys Leu Asp Asp Ser Asp Leu Arg Ser Arg 
            820                 825                 830         


Lys Leu Tyr Leu Tyr Tyr Thr Gln Met Gly Arg Asp Met Tyr Thr Gly 
        835                 840                 845             


Glu Lys Ile Asp Leu Asp Lys Leu Phe Asp Ser Thr His Tyr Asp Lys 
    850                 855                 860                 


Asp His Ile Ile Pro Gln Ser Met Lys Lys Asp Asp Ser Ile Ile Asn 
865                 870                 875                 880 


Asn Leu Val Leu Val Asn Lys Asn Ala Asn Gln Thr Thr Lys Gly Asn 
                885                 890                 895     


Ile Tyr Pro Val Pro Ser Ser Ile Arg Asn Asn Pro Lys Ile Tyr Asn 
            900                 905                 910         


Tyr Trp Lys Tyr Leu Met Glu Lys Glu Phe Ile Ser Lys Glu Lys Tyr 
        915                 920                 925             


Asn Arg Leu Ile Arg Asn Thr Pro Leu Thr Asn Glu Glu Leu Gly Gly 
    930                 935                 940                 


Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Ser Thr Lys Ala Ile 
945                 950                 955                 960 


Lys Glu Leu Phe Glu Lys Phe Tyr Lys Lys Ser Lys Ile Ile Pro Val 
                965                 970                 975     


Lys Ala Ile Leu Ala Ser Asp Leu Arg Lys Asp Met Asn Thr Leu Lys 
            980                 985                 990         


Ser Arg Glu Val Asn Asp Leu His  His Ala His Asp Ala  Phe Leu Asn 
        995                 1000                 1005             


Ile Val  Ala Gly Asp Val Trp  Asn Arg Glu Phe Thr  Ser Asn Pro 
    1010                 1015                 1020             


Ile Asn  Tyr Val Lys Glu Asn  Arg Glu Gly Asp Lys  Val Lys Tyr 
    1025                 1030                 1035             


Ser Leu  Ser Lys Tyr Phe Thr  Arg Pro Arg Lys Ser  Lys Gly Lys 
    1040                 1045                 1050             


Val Ile  Trp Thr Pro Glu Lys  Gly Arg Lys Leu Ile  Val Asp Thr 
    1055                 1060                 1065             


Leu Asn  Lys Pro Ser Val Leu  Ile Ser Asn Glu Ser  His Val Lys 
    1070                 1075                 1080             


Lys Gly  Glu Leu Phe Asn Ala  Thr Ile Ala Gly Lys  Lys Asp Tyr 
    1085                 1090                 1095             


Lys Lys  Gly Lys Ile Tyr Leu  Pro Leu Lys Lys Asp  Asp Arg Leu 
    1100                 1105                 1110             


Gln Asp  Val Ser Lys Tyr Gly  Gly Tyr Lys Ala Ile  Asn Gly Ala 
    1115                 1120                 1125             


Phe Phe  Phe Leu Val Glu His  Thr Lys Ser Lys Lys  Arg Ile Arg 
    1130                 1135                 1140             


Ser Ile  Glu Leu Phe Pro Leu  His Leu Leu Ser Lys  Phe Tyr Glu 
    1145                 1150                 1155             


Asp Lys  Asn Thr Val Leu Asp  Tyr Ala Ile Asn Val  Leu Gln Leu 
    1160                 1165                 1170             


Gln Asp  Pro Lys Ile Ile Ile  Asp Lys Ile Asn Tyr  Arg Thr Glu 
    1175                 1180                 1185             


Ile Ile  Ile Asp Asn Phe Ser  Tyr Leu Ile Ser Thr  Lys Ser Asn 
    1190                 1195                 1200             


Asp Gly  Ser Ile Thr Val Lys  Pro Asn Glu Gln Met  Tyr Trp Arg 
    1205                 1210                 1215             


Val Asp  Glu Ile Ser Asn Leu  Lys Lys Ile Glu Asn  Lys Tyr Lys 
    1220                 1225                 1230             


Lys Asp  Ala Ile Leu Thr Glu  Glu Asp Arg Lys Ile  Met Glu Ser 
    1235                 1240                 1245             


Tyr Ile  Asp Lys Ile Tyr Gln  Gln Phe Lys Ala Gly  Lys Tyr Lys 
    1250                 1255                 1260             


Asn Arg  Arg Thr Thr Asp Thr  Ile Ile Glu Lys Tyr  Glu Ile Ile 
    1265                 1270                 1275             


Asp Leu  Asp Thr Leu Asp Asn  Lys Gln Leu Tyr Gln  Leu Leu Val 
    1280                 1285                 1290             


Ala Phe  Ile Ser Leu Ser Tyr  Lys Thr Ser Asn Asn  Ala Val Asp 
    1295                 1300                 1305             


Phe Thr  Val Ile Gly Leu Gly  Thr Glu Cys Gly Lys  Pro Arg Ile 
    1310                 1315                 1320             


Thr Asn  Leu Pro Asp Asn Thr  Tyr Leu Val Tyr Lys  Ser Ile Thr 
    1325                 1330                 1335             


Gly Ile  Tyr Glu Lys Arg Ile  Arg Ile Lys 
    1340                 1345             


<210> 220
<211> 1516
<212> PRT
<213> Flavobacteriaceae bacterium


<220>
<223> Flavobacteriaceae bacterium S85

<400> 220
Met Leu Lys Gln Gln Lys Asp Lys Ile Ile Gly Met Asn Lys Lys Ile 
1               5                   10                  15      


Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp Ala Leu Val Lys 
            20                  25                  30          


Gln Asp Leu Glu Asn Lys Tyr Gly Glu Ile Ile Gly Cys Gly Ser Arg 
        35                  40                  45              


Ile Ile Pro Met Ser Gln Asp Val Leu Gly Lys Phe Asp Ala Gly Ile 
    50                  55                  60                  


Ser Ile Ser Gln Thr Ala Glu Arg Thr Asn Tyr Arg Ser Val Arg Lys 
65                  70                  75                  80  


Leu Ile Gln Arg Asn Thr Leu Arg Arg Glu Arg Leu His Arg Val Leu 
                85                  90                  95      


His Gln Leu Asp Phe Leu Pro Lys His Tyr Asn Asp Ser Ile Asp Phe 
            100                 105                 110         


Glu Lys Lys Leu Gly Gln Phe Lys Thr Asp Lys Glu Thr Lys Leu Asn 
        115                 120                 125             


Tyr Phe Val Asn Gln His Gly Lys His Glu Phe Leu Phe Lys Asp Ser 
    130                 135                 140                 


Phe Asn Glu Met Val Lys Glu Phe Lys Glu Glu Gln Pro Glu Leu Phe 
145                 150                 155                 160 


Tyr Ile Lys Asn Asn Gly Lys Glu Thr Lys Ile Pro Tyr Asp Trp Thr 
                165                 170                 175     


Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Lys Lys Ile Ser Lys Glu 
            180                 185                 190         


Glu Leu Ser Trp Leu Val Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr 
        195                 200                 205             


Gln Leu Arg Gly Glu Ile Asp Glu Glu Lys Glu Lys Asn Lys Arg Tyr 
    210                 215                 220                 


Glu Lys Leu Tyr Val Ser Glu Val Val Lys Thr Asn Asn Thr Ile Lys 
225                 230                 235                 240 


Lys Thr Gly Glu Tyr Leu Tyr Asp Ile Tyr Phe Asp Asn Gly Trp Lys 
                245                 250                 255     


Tyr Glu Lys Gln Thr Thr Lys Pro Gln Asp Trp Leu His Lys His Lys 
            260                 265                 270         


Glu Phe Ile Ile Thr Thr Thr Thr Leu Lys Asn Gly Glu Thr Lys Arg 
        275                 280                 285             


Thr Phe Lys Thr Val Asp Ser Glu Lys Asp Trp Ile Ala Ile Lys Ser 
    290                 295                 300                 


Lys Thr Glu Gln Asp Ile Lys Glu Ser Asn Lys Thr Val Gly Ala Phe 
305                 310                 315                 320 


Ile Tyr Asp Thr Leu Leu Lys Asn Pro Thr Gln Lys Ile Arg Gly Ser 
                325                 330                 335     


Leu Val Lys Thr Ile Glu Arg Lys Phe Tyr Arg Glu Glu Phe Glu Lys 
            340                 345                 350         


Ile Leu Lys Glu Gln Ile Lys His Arg Pro Glu Ile Asn Val Asn Thr 
        355                 360                 365             


Ala Ile Gly Lys Glu Asn Tyr Thr Lys Cys Val Thr Glu Leu Tyr Pro 
    370                 375                 380                 


Arg Asn Glu Ala His Ala Asn Asn Ile Leu Thr Asn Asp Phe Asn Tyr 
385                 390                 395                 400 


Leu Phe Thr Lys Asp Ile Leu Phe Tyr Gln Arg Pro Leu Lys Ser Lys 
                405                 410                 415     


Lys Ser Glu Ile Ala Asn Cys Gln Tyr Glu Tyr Arg Thr Tyr Ile Lys 
            420                 425                 430         


Lys Lys Glu Lys Thr Gly Lys Glu Glu Arg Val Lys Gln Pro Leu Lys 
        435                 440                 445             


Ala Thr Pro Lys Ser His Pro Leu Phe Gln Glu Phe Arg Leu Trp Gln 
    450                 455                 460                 


Phe Ile His Asn Leu Lys Ile Tyr Ile Arg Glu Thr Thr Val Gly Asn 
465                 470                 475                 480 


Lys Pro Leu Phe Asp Val Asp Ile Thr Asp Thr Phe Phe Thr Ser Glu 
                485                 490                 495     


Asn Asp Trp Ala Thr Leu Phe Glu Tyr Leu Asn Asn Lys Lys Glu Ile 
            500                 505                 510         


Glu Gln Lys His Val Leu Glu Tyr Leu Val Ser Lys Lys Ile Ile Ser 
        515                 520                 525             


Lys Ser Glu Lys Thr Asp Tyr Arg Trp Asn Tyr Val Glu Asp Lys Lys 
    530                 535                 540                 


Tyr Pro Gly Asn Glu Thr Arg Val Asp Phe Ile Asn Arg Leu Lys Lys 
545                 550                 555                 560 


Val Glu Asn Leu Asn Val Asp Glu Phe Leu Thr Ser Glu Leu Glu Phe 
                565                 570                 575     


Lys Leu Trp His Ile Ile Tyr Ser Val Thr Asp Lys Asn Glu Tyr Glu 
            580                 585                 590         


Lys Ala Leu Glu Asn Phe Ala Ile Arg Gln Asn Ile Asp Lys Asp Ser 
        595                 600                 605             


Phe Val Asn Ser Phe Lys Lys Phe Pro Pro Phe Lys Ser Asp Tyr Gly 
    610                 615                 620                 


Ala Tyr Ser Thr Lys Ala Ile Lys Lys Leu Leu Pro Leu Met Arg Leu 
625                 630                 635                 640 


Gly Lys Phe Trp Asp Gly Ser Glu Ile Pro Lys Val Val Val Glu Lys 
                645                 650                 655     


Ile Thr Asp Ile Lys Thr Arg Leu Thr Ser Val Asn Tyr Asp Glu Ser 
            660                 665                 670         


Leu Phe Lys Lys Asp Glu Lys Lys Ile Leu Glu Thr Ile Val Asp Asp 
        675                 680                 685             


Ile Thr Pro Lys Gln Leu Leu Lys Ser Phe Val Lys Leu Lys Gly Lys 
    690                 695                 700                 


Asn His Leu Ala Gly Leu Asn Thr Tyr Gln Ala Cys Tyr Leu Val Tyr 
705                 710                 715                 720 


Glu Arg His Ser Glu Ser Ser Asp Ile Thr Gln Trp Glu Asn Pro Asp 
                725                 730                 735     


Asp Ile Asp Ser Phe Leu Asn His Phe Lys Gln His Ser Leu Arg Asn 
            740                 745                 750         


Pro Ile Val Glu Gln Val Val Thr Glu Thr Leu Arg Thr Val Arg Asp 
        755                 760                 765             


Ile Trp Lys Tyr Tyr Gly Asn Gly Ser Pro Asn Tyr Phe Asn Glu Ile 
    770                 775                 780                 


His Ile Glu Leu Gly Arg Glu Met Lys Asn Pro Ala Asp Lys Arg Lys 
785                 790                 795                 800 


Gln Met Ser Ala Lys Ile Asn Glu Asn Glu Asn Thr Asn Gln Arg Ile 
                805                 810                 815     


Lys Gly Ile Leu Gln Glu Leu Met Asn Asp Gly Val Gln Asp Ile Lys 
            820                 825                 830         


Pro Tyr Ser Pro Ser Gln Gln Glu Ile Leu Lys Ile Tyr Glu Glu Gly 
        835                 840                 845             


Ile Ser Gln Asn Pro Asn Val Asp Tyr Ser Lys Val Ser Glu Asp Glu 
    850                 855                 860                 


Ile Thr Lys Ile Lys Lys Ser Asn Asn Pro Thr Leu Lys Glu Ile Gln 
865                 870                 875                 880 


Arg Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Ile Ser Pro Tyr Thr Gly 
                885                 890                 895     


Lys Pro Ile Pro Leu Ser Glu Leu Phe Thr Pro Ala Tyr Gln Ile Glu 
            900                 905                 910         


His Ile Ile Pro Gln Ser Arg Tyr Phe Asp Asn Ser Leu Ser Asn Lys 
        915                 920                 925             


Ile Ile Cys Glu Ser Glu Val Asn Glu Asp Lys Ser Asn Lys Thr Ala 
    930                 935                 940                 


Tyr Glu Tyr Leu Lys Thr Asn Gly Gly Ser Ile Val His Gly His His 
945                 950                 955                 960 


Leu Leu Ser Leu Lys Glu Tyr Glu Asp His Cys Gln His Tyr Phe Lys 
                965                 970                 975     


Lys Asn Arg Thr Lys Leu Lys Asn Leu Leu Ser Glu Glu Ile Pro Glu 
            980                 985                 990         


Gly Phe Ile Asn Arg Gln Leu Asn  Asp Ser Arg Tyr Ile  Ser Lys Leu 
        995                 1000                 1005             


Ile Lys  Gly Leu Leu Ser Asn  Ile Val Arg Glu Glu  Asn Glu Gln 
    1010                 1015                 1020             


Glu Ala  Thr Ser Lys Asn Ile  Val Pro Val Thr Gly  Ser Ile Thr 
    1025                 1030                 1035             


Ser Lys  Leu Lys Gln Asp Trp  Gly Leu Asn Asp Lys  Trp Asn Glu 
    1040                 1045                 1050             


Ile Ile  Ala Pro Arg Phe Lys  Arg Leu Asn Lys Met  Thr Asn Ser 
    1055                 1060                 1065             


Asn Asp  Phe Gly Tyr Phe Asp  Glu Lys Ile Asn Thr  Phe Arg Ile 
    1070                 1075                 1080             


Gln Val  Pro Asp Ala Ile Ser  Arg Gly Phe Asn Lys  Lys Arg Ile 
    1085                 1090                 1095             


Asp His  Arg His His Thr Leu  Asp Ala Leu Val Ile  Ala Cys Cys 
    1100                 1105                 1110             


Thr Lys  Lys His Ile Gln Tyr  Leu Asn Ser Leu Asn  Asn Glu Ile 
    1115                 1120                 1125             


Ile Lys  His Glu Leu Lys Pro  Ser Ile Leu Ile Lys  Asn Ala Gln 
    1130                 1135                 1140             


Gly Asp  Tyr Thr Lys His Phe  Met Leu Pro Trp Asn  Asn Phe Pro 
    1145                 1150                 1155             


Ile Asp  Cys Lys Asn Ala Ile  Glu Asn Thr Ile Val  Ser Phe Lys 
    1160                 1165                 1170             


Gln Asn  Leu Arg Val Ile Asn  Lys Thr Ser Asn Lys  Tyr Gln Ser 
    1175                 1180                 1185             


Tyr Lys  Asp Glu Asn Gly Asn  Leu Arg Leu Gly Lys  Asp Gly Lys 
    1190                 1195                 1200             


Pro Lys  Lys Gly Leu Thr Lys  Gln Thr Lys Gly Asn  Asn Trp Ala 
    1205                 1210                 1215             


Val Arg  Lys Ala Met His Glu  Asp Thr Phe Tyr Gly  Glu Ile Val 
    1220                 1225                 1230             


Asp Gly  Glu Asn Lys Gly Lys  Leu Lys Ile Lys Thr  Leu Leu Asp 
    1235                 1240                 1245             


Thr Ser  Phe Asp Val Lys Lys  Ile Glu Asp Lys Val  Leu Asp Lys 
    1250                 1255                 1260             


Ser Ile  Arg Thr Ile Leu Ile  Asn Tyr Leu Lys Gln  Asp Lys Tyr 
    1265                 1270                 1275             


Lys Asn  Leu Ser Lys Pro His  Glu Glu Ala Phe Ser  Pro Asn Gly 
    1280                 1285                 1290             


Ile Ile  Glu Met Asn Lys Asn  Ile Ile Ser Leu Asn  Asn Asn Ile 
    1295                 1300                 1305             


Pro His  Lys Pro Ile Lys Arg  Val Thr Leu Lys His  Glu Lys Gly 
    1310                 1315                 1320             


Lys Lys  Phe Ser Ile Lys Thr  Leu Leu Asp Lys Lys  Thr Lys Phe 
    1325                 1330                 1335             


Ala Lys  Ser Ala Thr Gly Thr  Asn Val Phe Phe Cys  Ile Tyr Lys 
    1340                 1345                 1350             


Asn Ile  Asn Gly Lys Ile Lys  Tyr His Thr Pro Ser  Phe Glu Glu 
    1355                 1360                 1365             


Ile Ile  Glu Ile Gln Lys Gln  Glu Phe Glu Ile Lys  Tyr Lys Ser 
    1370                 1375                 1380             


Lys Leu  Asn Val Pro Glu Thr  Leu Phe Asp Lys Lys  Glu Ser Phe 
    1385                 1390                 1395             


Glu Leu  Leu Phe Tyr Leu Gln  Pro Asn Asp Leu Val  Tyr Leu Pro 
    1400                 1405                 1410             


Asn Asp  Glu Glu Leu Lys Asn  Arg Gln Leu Ile Asp  Phe Asn Asn 
    1415                 1420                 1425             


Leu Asn  Lys Lys Gln Ile Lys  Arg Ile Tyr Lys Phe  Thr Asp Gly 
    1430                 1435                 1440             


Ser Gly  Thr Thr Ala Asn Phe  Ile Pro Tyr Gln Val  Ala Lys Val 
    1445                 1450                 1455             


Ile Phe  Asn Leu Asn Lys Lys  Glu Gln Ala Lys Ser  Ser Phe Lys 
    1460                 1465                 1470             


Tyr Pro  Ile Gln Asn Glu Phe  Gly Val Gly Ser Pro  Gln Ser Lys 
    1475                 1480                 1485             


Asn Gln  Lys Ser Ile Glu Gly  Ile Leu Ile Lys Glu  Arg Cys Ile 
    1490                 1495                 1500             


Lys Leu  Lys Ile Asp Arg Leu  Gly Asn Ile Ser Lys  Ala 
    1505                 1510                 1515     


<210> 221
<211> 1473
<212> PRT
<213> Flavobacterium branchiophilum

<400> 221
Met Ala Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Val Glu Arg Glu Asn Ile Asp Phe Ser Leu Ile Asp Lys Gly 
            20                  25                  30          


Val Arg Ile Phe Ser Glu Gly Val Lys Ser Glu Lys Gly Ile Glu Ser 
        35                  40                  45              


Ser Arg Ala Ala Glu Arg Thr Gly Tyr Arg Ser Ala Arg Lys Ile Lys 
    50                  55                  60                  


Tyr Arg Arg Lys Leu Arg Lys Tyr Glu Thr Leu Lys Val Leu Ser Leu 
65                  70                  75                  80  


Asn Arg Met Cys Pro Leu Ser Ile Glu Glu Val Glu Glu Trp Lys Lys 
                85                  90                  95      


Ser Gly Phe Lys Asp Tyr Pro Leu Asn Pro Glu Phe Leu Lys Trp Leu 
            100                 105                 110         


Ser Thr Asp Glu Glu Ser Asn Val Asn Pro Tyr Phe Phe Arg Asp Arg 
        115                 120                 125             


Ala Ser Lys His Lys Val Ser Leu Phe Glu Leu Gly Arg Ala Phe Tyr 
    130                 135                 140                 


His Ile Ala Gln Arg Arg Gly Phe Leu Ser Asn Arg Leu Asp Gln Ser 
145                 150                 155                 160 


Ala Glu Gly Ile Leu Glu Glu His Cys Pro Lys Ile Glu Ala Ile Val 
                165                 170                 175     


Glu Asp Leu Ile Ser Ile Asp Glu Ile Ser Thr Asn Ile Thr Asp Tyr 
            180                 185                 190         


Phe Phe Glu Thr Gly Ile Leu Asp Ser Asn Glu Lys Asn Gly Tyr Ala 
        195                 200                 205             


Lys Asp Leu Asp Glu Gly Asp Lys Lys Leu Val Ser Leu Tyr Lys Ser 
    210                 215                 220                 


Leu Leu Ala Ile Leu Lys Lys Asn Glu Ser Asp Phe Glu Asn Cys Lys 
225                 230                 235                 240 


Ser Glu Ile Ile Glu Arg Leu Asn Lys Lys Asp Val Leu Gly Lys Val 
                245                 250                 255     


Lys Gly Lys Ile Lys Asp Ile Ser Gln Ala Met Leu Asp Gly Asn Tyr 
            260                 265                 270         


Lys Thr Leu Gly Gln Tyr Phe Tyr Ser Leu Tyr Ser Lys Glu Lys Ile 
        275                 280                 285             


Arg Asn Gln Tyr Thr Ser Arg Glu Glu His Tyr Leu Ser Glu Phe Ile 
    290                 295                 300                 


Thr Ile Cys Lys Val Gln Gly Ile Asp Gln Ile Asn Glu Glu Glu Lys 
305                 310                 315                 320 


Ile Asn Glu Lys Lys Phe Asp Gly Leu Ala Lys Asp Leu Tyr Lys Ala 
                325                 330                 335     


Ile Phe Phe Gln Arg Pro Leu Lys Ser Gln Lys Gly Leu Ile Gly Lys 
            340                 345                 350         


Cys Ser Phe Glu Lys Ser Lys Ser Arg Cys Ala Ile Ser His Pro Asp 
        355                 360                 365             


Phe Glu Glu Tyr Arg Met Trp Thr Tyr Leu Asn Thr Ile Lys Ile Gly 
    370                 375                 380                 


Thr Gln Ser Asp Lys Lys Leu Arg Phe Leu Thr Gln Asp Glu Lys Leu 
385                 390                 395                 400 


Lys Leu Val Pro Lys Phe Tyr Arg Lys Asn Asp Phe Asn Phe Asp Val 
                405                 410                 415     


Leu Ala Lys Glu Leu Ile Glu Lys Gly Ser Ser Phe Gly Phe Tyr Lys 
            420                 425                 430         


Ser Ser Lys Lys Asn Asp Phe Phe Tyr Trp Phe Asn Tyr Lys Pro Thr 
        435                 440                 445             


Asp Thr Val Ala Ala Cys Gln Val Ala Ala Ser Leu Lys Asn Ala Ile 
    450                 455                 460                 


Gly Glu Asp Trp Lys Thr Lys Ser Phe Lys Tyr Gln Thr Ile Asn Ser 
465                 470                 475                 480 


Asn Lys Glu Gln Val Ser Arg Thr Val Asp Tyr Lys Asp Leu Trp His 
                485                 490                 495     


Leu Leu Thr Val Ala Thr Ser Asp Val Tyr Leu Tyr Glu Phe Ala Ile 
            500                 505                 510         


Asp Lys Leu Gly Leu Asp Glu Lys Asn Ala Lys Ala Phe Ser Lys Thr 
        515                 520                 525             


Lys Leu Lys Lys Asp Phe Ala Ser Leu Ser Leu Ser Ala Ile Asn Lys 
    530                 535                 540                 


Ile Leu Pro Tyr Leu Lys Glu Gly Leu Leu Tyr Ser His Ala Val Phe 
545                 550                 555                 560 


Val Ala Asn Ile Glu Asn Ile Val Asp Glu Asn Ile Trp Lys Asp Glu 
                565                 570                 575     


Lys Gln Arg Asp Tyr Ile Lys Thr Gln Ile Ser Glu Ile Ile Glu Asn 
            580                 585                 590         


Tyr Thr Leu Glu Lys Ser Arg Phe Glu Ile Ile Asn Gly Leu Leu Lys 
        595                 600                 605             


Glu Tyr Lys Ser Glu Asn Glu Asp Gly Lys Arg Val Tyr Tyr Ser Lys 
    610                 615                 620                 


Glu Ala Glu Gln Ser Phe Glu Asn Asp Leu Lys Lys Lys Leu Val Leu 
625                 630                 635                 640 


Phe Tyr Lys Ser Asn Glu Ile Glu Asn Lys Glu Gln Gln Glu Thr Ile 
                645                 650                 655     


Phe Asn Glu Leu Leu Pro Ile Phe Ile Gln Gln Leu Lys Asp Tyr Glu 
            660                 665                 670         


Phe Ile Lys Ile Gln Arg Leu Asp Gln Lys Val Leu Ile Phe Leu Lys 
        675                 680                 685             


Gly Lys Asn Glu Thr Gly Gln Ile Phe Cys Thr Glu Glu Lys Gly Thr 
    690                 695                 700                 


Ala Glu Glu Lys Glu Lys Lys Ile Lys Asn Arg Leu Lys Lys Leu Tyr 
705                 710                 715                 720 


His Pro Ser Asp Ile Glu Lys Phe Lys Lys Lys Ile Ile Lys Asp Glu 
                725                 730                 735     


Phe Gly Asn Glu Lys Ile Val Leu Gly Ser Pro Leu Thr Pro Ser Ile 
            740                 745                 750         


Lys Asn Pro Met Ala Met Arg Ala Leu His Gln Leu Arg Lys Val Leu 
        755                 760                 765             


Asn Ala Leu Ile Leu Glu Gly Gln Ile Asp Glu Lys Thr Ile Ile His 
    770                 775                 780                 


Ile Glu Met Ala Arg Glu Leu Asn Asp Ala Asn Lys Arg Lys Gly Ile 
785                 790                 795                 800 


Gln Asp Tyr Gln Asn Asp Asn Lys Lys Phe Arg Glu Asp Ala Ile Lys 
                805                 810                 815     


Glu Ile Lys Lys Leu Tyr Phe Glu Asp Cys Lys Lys Glu Val Glu Pro 
            820                 825                 830         


Thr Glu Asp Asp Ile Leu Arg Tyr Gln Leu Trp Met Glu Gln Asn Arg 
        835                 840                 845             


Ser Glu Ile Tyr Glu Glu Gly Lys Asn Ile Ser Ile Cys Asp Ile Ile 
    850                 855                 860                 


Gly Ser Asn Pro Ala Tyr Asp Ile Glu His Thr Ile Pro Arg Ser Arg 
865                 870                 875                 880 


Ser Gln Asp Asn Ser Gln Met Asn Lys Thr Leu Cys Ser Gln Arg Phe 
                885                 890                 895     


Asn Arg Glu Val Lys Lys Gln Ser Met Pro Ile Glu Leu Asn Asn His 
            900                 905                 910         


Leu Glu Ile Leu Pro Arg Ile Ala His Trp Lys Glu Glu Ala Asp Asn 
        915                 920                 925             


Leu Thr Arg Glu Ile Glu Ile Ile Ser Arg Ser Ile Lys Ala Ala Ala 
    930                 935                 940                 


Thr Lys Glu Ile Lys Asp Lys Lys Ile Arg Arg Arg His Tyr Leu Thr 
945                 950                 955                 960 


Leu Lys Arg Asp Tyr Leu Gln Gly Lys Tyr Asp Arg Phe Ile Trp Glu 
                965                 970                 975     


Glu Pro Lys Val Gly Phe Lys Asn Ser Gln Ile Pro Asp Thr Gly Ile 
            980                 985                 990         


Ile Thr Lys Tyr Ala Gln Ala Tyr  Leu Lys Ser Tyr Phe  Lys Lys Val 
        995                 1000                 1005             


Glu Ser  Val Lys Gly Gly Met  Val Ala Glu Phe Arg  Lys Ile Trp 
    1010                 1015                 1020             


Gly Ile  Gln Glu Ser Phe Ile  Asp Glu Asn Gly Met  Lys His Tyr 
    1025                 1030                 1035             


Lys Val  Lys Asp Arg Ser Lys  His Thr His His Thr  Ile Asp Ala 
    1040                 1045                 1050             


Ile Thr  Ile Ala Cys Met Thr  Lys Glu Lys Tyr Asp  Val Leu Ala 
    1055                 1060                 1065             


His Ala  Trp Thr Leu Glu Asp  Gln Gln Asn Lys Lys  Glu Ala Arg 
    1070                 1075                 1080             


Ser Ile  Ile Glu Ala Ser Lys  Pro Trp Lys Thr Phe  Lys Glu Asp 
    1085                 1090                 1095             


Leu Leu  Lys Ile Glu Glu Glu  Ile Leu Val Ser His  Tyr Thr Pro 
    1100                 1105                 1110             


Asp Asn  Val Lys Lys Gln Ala  Lys Lys Ile Val Arg  Val Arg Gly 
    1115                 1120                 1125             


Lys Lys  Gln Phe Val Ala Glu  Val Glu Arg Asp Val  Asn Gly Lys 
    1130                 1135                 1140             


Ala Val  Pro Lys Lys Ala Ala  Ser Gly Lys Thr Ile  Tyr Lys Leu 
    1145                 1150                 1155             


Asp Gly  Glu Gly Lys Lys Leu  Pro Arg Leu Gln Gln  Gly Asp Thr 
    1160                 1165                 1170             


Ile Arg  Gly Ser Leu His Gln  Asp Ser Ile Tyr Gly  Ala Ile Lys 
    1175                 1180                 1185             


Asn Pro  Leu Asn Thr Asp Glu  Ile Lys Tyr Val Ile  Arg Lys Asp 
    1190                 1195                 1200             


Leu Glu  Ser Ile Lys Gly Ser  Asp Val Glu Ser Ile  Val Asp Glu 
    1205                 1210                 1215             


Val Val  Lys Glu Lys Ile Lys  Glu Ala Ile Ala Asn  Lys Val Leu 
    1220                 1225                 1230             


Leu Leu  Ser Ser Asn Ala Gln  Gln Lys Asn Lys Leu  Val Gly Thr 
    1235                 1240                 1245             


Val Trp  Met Asn Glu Glu Lys  Arg Ile Ala Ile Asn  Lys Val Arg 
    1250                 1255                 1260             


Ile Tyr  Ala Asn Ser Val Lys  Asn Pro Leu His Ile  Lys Glu His 
    1265                 1270                 1275             


Ser Leu  Leu Ser Lys Ser Lys  His Val His Lys Gln  Lys Val Tyr 
    1280                 1285                 1290             


Gly Gln  Asn Asp Glu Asn Tyr  Ala Met Ala Ile Tyr  Glu Leu Asp 
    1295                 1300                 1305             


Gly Lys  Arg Asp Phe Glu Leu  Ile Asn Ile Phe Asn  Leu Ala Lys 
    1310                 1315                 1320             


Leu Ile  Lys Gln Gly Gln Gly  Phe Tyr Pro Leu His  Lys Lys Lys 
    1325                 1330                 1335             


Glu Ile  Lys Gly Lys Ile Val  Phe Val Pro Ile Glu  Lys Arg Asn 
    1340                 1345                 1350             


Lys Arg  Asp Val Val Leu Lys  Arg Gly Gln Gln Val  Val Phe Tyr 
    1355                 1360                 1365             


Asp Lys  Glu Val Glu Asn Pro  Lys Asp Ile Ser Glu  Ile Val Asp 
    1370                 1375                 1380             


Phe Lys  Gly Arg Ile Tyr Ile  Ile Glu Gly Leu Ser  Ile Gln Arg 
    1385                 1390                 1395             


Ile Val  Arg Pro Ser Gly Lys  Val Asp Glu Tyr Gly  Val Ile Met 
    1400                 1405                 1410             


Leu Arg  Tyr Phe Lys Glu Ala  Arg Lys Ala Asp Asp  Ile Lys Gln 
    1415                 1420                 1425             


Asp Asn  Phe Lys Pro Asp Gly  Val Phe Lys Leu Gly  Glu Asn Lys 
    1430                 1435                 1440             


Pro Thr  Arg Lys Met Asn His  Asn Gln Phe Thr Ala  Phe Val Glu 
    1445                 1450                 1455             


Gly Ile  Asp Phe Lys Val Leu  Pro Ser Gly Lys Phe  Glu Lys Ile 
    1460                 1465                 1470             


<210> 222
<211> 1459
<212> PRT
<213> Flavobacterium columnare

<400> 222
Met Lys Phe Asn Leu Gly Leu Asp Ile Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Asp Tyr Glu Asn Lys Lys Gly Lys Ile Ile Ala 
            20                  25                  30          


Ala Gly Ser Arg Ile Ile Pro Met Thr Gln Asp Ile Leu Asp Lys Phe 
        35                  40                  45              


Gly Ser Gly Ala Ile Thr Glu Thr Gln Thr Ala Leu Arg Thr Asp Tyr 
    50                  55                  60                  


Arg Ser Lys Arg Lys Leu Ile Gln Arg Phe Leu Leu Arg Arg Glu Arg 
65                  70                  75                  80  


Leu His Arg Val Leu Asn Val Leu Asp Phe Leu Pro Lys His Tyr Ala 
                85                  90                  95      


Glu Ser Ile Asp Phe Glu Lys Tyr Phe Gly Lys Phe Leu Pro Asn Thr 
            100                 105                 110         


Glu Pro Lys Leu Ala Tyr Asn Gln Asn Gln Phe Ile Phe Gln Asn Ser 
        115                 120                 125             


Phe Leu Glu Met Leu Lys Glu Phe Gln Glu Lys His Pro Glu Leu Leu 
    130                 135                 140                 


Thr Asn Asn Lys Lys Ile Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg 
145                 150                 155                 160 


Lys Lys Ala Leu Asn Gln Arg Ile Glu Lys Glu Glu Leu Ala Trp Leu 
                165                 170                 175     


Leu Leu Gln Phe Asn Gln Lys Arg Gly Tyr Asn Gln Leu Arg Asp Glu 
            180                 185                 190         


Glu Glu Glu Ser Val Pro Asn Lys Gln Val Glu Phe Tyr Ser Leu Lys 
        195                 200                 205             


Ile Ile Asp Val Val Ala Asp Gln Pro Lys Glu Gly Arg Asp Lys Arg 
    210                 215                 220                 


Trp Tyr Ser Ile Asn Leu Glu Asn Gly Trp Thr Tyr Arg Arg Glu Ser 
225                 230                 235                 240 


Lys Thr Pro Leu Phe Asn Trp Glu Gly Lys Thr Lys Asp Phe Ile Val 
                245                 250                 255     


Thr Thr Asp Leu Asn Gln Asp Gly Ser Ile Lys Lys Asp Lys Glu Gly 
            260                 265                 270         


Lys Glu Lys Arg Ser Phe Arg Ala Pro Ser Glu Gly Asp Trp Thr Leu 
        275                 280                 285             


Leu Lys Lys Lys Thr Glu Lys Glu Ile Tyr Glu Ser Gly Lys Thr Leu 
    290                 295                 300                 


Gly Thr Tyr Ile Tyr Asp Ala Leu Leu Asn Thr Pro Asp Leu Lys Ile 
305                 310                 315                 320 


Lys Gly Asp Phe Ile Arg Thr Ile Asp Arg Ser Ile Tyr Lys Glu Glu 
                325                 330                 335     


Leu Gln Gln Ile Ile Asn Lys Gln Lys Glu Tyr His Leu Glu Leu Asn 
            340                 345                 350         


Ser Ser Lys Leu Tyr Lys Ala Cys Leu Glu Glu Leu Tyr Pro Lys Asn 
        355                 360                 365             


Glu Ile Tyr Lys Ser Ala Leu Lys Asn Lys Asp Ile Ala Tyr Leu Phe 
    370                 375                 380                 


Ile Asn Asp Ile Leu Tyr Tyr Gln Arg Pro Leu Lys Ala Pro Lys Tyr 
385                 390                 395                 400 


Asn Ile Gly Lys Cys Thr Tyr Glu Ser Arg Thr Phe Lys Lys Glu Asp 
                405                 410                 415     


Lys Lys Ile Arg Glu Tyr Ile Pro Ala Val Ala Lys Ser His Pro Leu 
            420                 425                 430         


Phe Gln Glu Phe Arg Leu Trp Gln Trp Ile Lys Asn Leu Lys Ile Tyr 
        435                 440                 445             


Glu Lys Leu Ser Ser Asp Asn Cys Thr Asp Phe Phe Leu Thr Asn Glu 
    450                 455                 460                 


Gln Asp Phe Glu Asn Leu Phe Glu Phe Leu Trp Asn Lys Lys Glu Ile 
465                 470                 475                 480 


Asp His Lys Gly Ile Leu Glu Tyr Leu Val Lys Thr Lys Phe Pro Asp 
                485                 490                 495     


Leu Lys Pro Lys Gln Val Lys Thr Lys Val Lys Glu Tyr Arg Trp Asn 
            500                 505                 510         


Tyr Val Tyr Asp His Glu Lys Asp Glu Ser Lys Thr Tyr Pro Cys Gly 
        515                 520                 525             


Glu Thr Tyr Phe Leu Leu Lys Asn Lys Leu Asp Lys Ile Tyr Asn Ala 
    530                 535                 540                 


Gln Asp Asp Phe Leu Asp Lys Glu Arg Leu Tyr Asn Leu Trp His Ile 
545                 550                 555                 560 


Ile Tyr Ser Val Thr Asp Lys Lys Gln Tyr Glu Lys Ala Leu Ala Lys 
                565                 570                 575     


Phe Ala Leu Lys Asn His Leu Asp Thr Lys Ser Phe Val Asn Thr Phe 
            580                 585                 590         


Lys Arg Ile Pro Pro Phe Lys Asn Asp Tyr Ala Ile Tyr Ser Leu Lys 
        595                 600                 605             


Ala Ile Lys Lys Leu Leu Pro Leu Met Arg Val Gly Lys Tyr Trp Asn 
    610                 615                 620                 


Tyr Asp Asp Ile Asp Pro Ile Thr Lys Gln Lys Ile Gln Cys Ile Ile 
625                 630                 635                 640 


Thr Gly Glu Glu Asn Asp Thr Ile Ser Thr Leu Val Arg Glu Lys Thr 
                645                 650                 655     


Asn His Phe Ser Asn Glu Asn Asp Phe Lys Asn Leu Pro Leu Trp Leu 
            660                 665                 670         


Ala Gly Tyr Ile Val Tyr Asn Ser His Asn Glu Ser Ser Glu Ile Glu 
        675                 680                 685             


Lys Trp Lys Ser Pro Gln Asp Ile Asp Thr Phe Leu Lys Lys Phe Lys 
    690                 695                 700                 


Gln His Ala Leu Arg Asn Pro Ile Val Glu Gln Val Val Thr Glu Thr 
705                 710                 715                 720 


Leu Arg Val Val Arg Asp Ile Trp Ser Lys Lys Gly Gln Gly Lys Lys 
                725                 730                 735     


Asp Phe Phe Asn Glu Ile His Ile Glu Leu Gly Lys Asp Leu Lys Asn 
            740                 745                 750         


Pro Val Asp Lys Arg Arg Lys Leu Ser Ser Thr Asn Thr Lys Asn Glu 
        755                 760                 765             


Ser Thr Asn Thr Arg Ile Lys Ala Leu Leu Ile Glu Leu Phe Thr Gln 
    770                 775                 780                 


Gly Val Glu Asn Val Lys Pro Asn Ser Pro Lys His Gln Glu Ile Leu 
785                 790                 795                 800 


Lys Ile Phe Glu Glu Gly Ala Leu Asn Ser Gly Ile Glu Ile Glu Glu 
                805                 810                 815     


Asp Ile Ile Lys Ile Ser Asn Thr Asp Gln Pro Thr Lys Lys Gln Leu 
            820                 825                 830         


Glu Leu Tyr Ile Leu Trp Leu Glu His Lys Tyr Lys Ser Pro Tyr Thr 
        835                 840                 845             


Gly Gln Ser Ile Pro Leu Ser Lys Leu Phe Thr Pro Asn Tyr Glu Ile 
    850                 855                 860                 


Glu His Ile Ile Pro Arg Ser Lys Tyr Tyr Asp Asp Asn Leu Ser Asn 
865                 870                 875                 880 


Lys Val Ile Cys Glu Thr Glu Ile Asn Arg Leu Lys Asn Asn Gln Leu 
                885                 890                 895     


Gly Tyr Glu Phe Ile Asn Asn His Glu Ile Arg Glu Val Thr Leu Glu 
            900                 905                 910         


Glu Gly Lys Thr Ile Arg Leu Leu Ser Pro Glu Gln Tyr Trp Asn Phe 
        915                 920                 925             


Val Thr Thr Tyr Tyr Ala Lys Asn Lys Ala Lys Arg Glu Asn Leu Leu 
    930                 935                 940                 


Leu Lys Glu Leu Pro Val Gln Met Val Glu Lys Gln Leu Asn Asp Thr 
945                 950                 955                 960 


Arg Tyr Val Ser Lys Tyr Val Met Gln Leu Leu Ser Lys Ile Val Arg 
                965                 970                 975     


Lys Glu Asp Gly Thr Asp Asn Gly Ile Asn Ser Thr Asn Ile Leu Ser 
            980                 985                 990         


Ile Ser Gly Lys Met Thr Arg Ala  Leu Lys Asn Asp Trp  Asp Leu Asn 
        995                 1000                 1005             


Asp Val  Trp Asn Asp Leu Leu  Leu Tyr Arg Phe Glu  Arg Leu Asn 
    1010                 1015                 1020             


Thr Ile  Thr Lys Thr Asn Leu  Phe Thr Thr Tyr Ser  Glu Gln Lys 
    1025                 1030                 1035             


Gln Lys  Arg Met Pro Ile Val  Pro Asp Gln Tyr Ala  Lys Gly Phe 
    1040                 1045                 1050             


His Lys  Lys Arg Leu Asp His  Arg His His Ala Leu  Asp Ala Ile 
    1055                 1060                 1065             


Val Ile  Ala Cys Ile Thr Arg  Asn His Ile Asn Tyr  Met Asn Asn 
    1070                 1075                 1080             


Gln Asn  Ile Gln Gly Glu Lys  Leu Lys Lys Asn Ala  Ile Glu Lys 
    1085                 1090                 1095             


Glu Asn  Tyr Arg Glu Ile Leu  Gln Lys Ser Arg Leu  Asp Ile Arg 
    1100                 1105                 1110             


Ala Gln  Leu Cys Glu Lys Lys  Tyr Asn Asp Asn Asp  Pro Thr Lys 
    1115                 1120                 1125             


Tyr Asn  Trp Val Phe Ile Lys  Pro Trp Ala Asp Phe  Thr Glu Asn 
    1130                 1135                 1140             


Thr Lys  Asp Ile Leu Glu Ser  Ile Ile Pro Ser Phe  Lys Gln Asn 
    1145                 1150                 1155             


Leu Arg  Ile Ile Asn Lys Thr  Val Asn Tyr Tyr Glu  Lys Tyr Asn 
    1160                 1165                 1170             


Glu Asn  Gly Lys Lys Val Lys  Val Arg Gln Ile Lys  Gly Asp Asn 
    1175                 1180                 1185             


Trp Ala  Ile Arg Lys Pro Leu  His Lys Glu Thr Ile  Ser Gly Lys 
    1190                 1195                 1200             


Val His  Leu Ser Tyr Lys Thr  Pro Ala Lys Gly Lys  Ile Leu Thr 
    1205                 1210                 1215             


Ala Thr  Arg Lys Val Leu Asp  Ser Ser Met Asp Phe  Lys Ser Ile 
    1220                 1225                 1230             


Glu Lys  Ile Thr Asp Thr Gly  Ile Gln Lys Ile Leu  Lys Asn Tyr 
    1235                 1240                 1245             


Leu Glu  Tyr Lys Lys Ser Pro  Glu Leu Ala Phe Ser  Pro Glu Gly 
    1250                 1255                 1260             


Ile Glu  Glu Leu Asn Ala Thr  Ile Thr Lys Tyr Asn  Asn Gly Phe 
    1265                 1270                 1275             


His His  Lys Pro Ile Tyr Lys  Val Arg Ile Tyr Glu  Glu Gly Val 
    1280                 1285                 1290             


Lys Phe  Pro Leu Gly Asn Lys  Gly Asn Lys Lys Ser  Lys Tyr Val 
    1295                 1300                 1305             


Glu Ala  Glu Lys Gly Thr Asn  Leu Phe Phe Ala Ile  Tyr Lys Asp 
    1310                 1315                 1320             


Gln Glu  Asn Asn Arg Tyr Phe  Glu Thr Ile Pro Phe  Asn Asp Val 
    1325                 1330                 1335             


Leu Glu  Thr Leu Lys Lys Gly  Met Ser Ala Val Pro  Glu Lys Asn 
    1340                 1345                 1350             


Gln Glu  Glu Asn Thr Leu Val  Phe Ala Leu Ser Pro  Gln Asp Leu 
    1355                 1360                 1365             


Val Phe  Val Pro Thr Leu Asp  Glu Ile Glu Asn Pro  Asp Ile Val 
    1370                 1375                 1380             


Asp Phe  Lys Asn Leu Thr Lys  Asp Gln Thr Asn Arg  Ile Tyr Lys 
    1385                 1390                 1395             


Met Val  Ser Ser Ser Gly Lys  Gln Cys Phe Phe Ile  Lys Ala Glu 
    1400                 1405                 1410             


Val Ala  Thr Ser Ile Val Asn  Lys Met Glu Phe Ser  Thr Ser Asn 
    1415                 1420                 1425             


Lys Met  Glu Asn Ser Ile Glu  Gly Ile Gln Ile Lys  Ser Asn Cys 
    1430                 1435                 1440             


Trp Lys  Leu Lys Leu Asp Arg  Leu Gly Thr Ile Thr  Arg Val Ile 
    1445                 1450                 1455             


Lys 
    


<210> 223
<211> 1535
<212> PRT
<213> Flavobacterium columnare

<400> 223
Met Thr Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Ile Arg Asp Thr Glu Asn Glu Gly Ile Asn Gln Ile Leu Asp Lys 
            20                  25                  30          


Gly Ala Arg Ile Phe Ser Glu Gly Val Lys Ser Glu Asn Gly Lys Glu 
        35                  40                  45              


Ile Ser Arg Ala Ala Glu Arg Thr Ala Tyr Arg Ser Ala Arg Lys Ile 
    50                  55                  60                  


Lys Tyr Arg Arg Lys Leu Arg Lys Tyr Glu Thr Leu Lys Val Leu Ser 
65                  70                  75                  80  


Ile Asn Gly Met Cys Pro Leu Ser Val Glu Glu Val Glu Gln Trp Lys 
                85                  90                  95      


Lys Ser Gly Phe Lys Glu Tyr Pro Leu Asn Pro Glu Phe Leu Asp Trp 
            100                 105                 110         


Leu Arg Thr Asn Glu Asp Lys Asn Ile Asn Pro Tyr Leu Phe Arg Asp 
        115                 120                 125             


Lys Ala Ser Lys Gln Lys Val Thr Leu Phe Glu Leu Gly Arg Ala Leu 
    130                 135                 140                 


Tyr His Ile Ala Gln Arg Arg Gly Phe Leu Ser Asn Arg Leu Asp Gln 
145                 150                 155                 160 


Ser Ala Glu Gly Val Phe Glu Glu His Asn Pro Gln Ile Gln Asn Leu 
                165                 170                 175     


Ile Glu Asp Leu Asp Ser Ser Asn Thr Ile Leu Asn Glu Leu Lys Glu 
            180                 185                 190         


Tyr Tyr Ile Asn Leu Gly Ile Ile Asp Glu Thr Glu Lys Ser Gly Phe 
        195                 200                 205             


Lys Lys Asp Leu Asp Glu Gly Glu Lys Lys Leu Lys Ser Leu Tyr Asn 
    210                 215                 220                 


Ser Leu Val Ala Ile Thr Lys Lys Asn Ala Asn Asp Ile Glu Thr Cys 
225                 230                 235                 240 


Lys Gln Glu Leu Ile Ala Arg Leu Asn Lys Lys Glu Asp Leu Gly Lys 
                245                 250                 255     


Val Lys Gly Lys Ile Lys Asp Ile Ser Gln Ala Met Leu Asp Arg Asn 
            260                 265                 270         


Phe Lys Thr Leu Gly Gln Tyr Phe Phe Ser Leu Tyr Asn Lys Glu Arg 
        275                 280                 285             


Ile Arg Asn Gln Tyr Thr Ser Arg Glu Glu His Tyr Leu Glu Glu Phe 
    290                 295                 300                 


Ile Ile Ile Cys Gln Thr Gln Gly Ile Glu Gly Ile Asn Thr Asn Glu 
305                 310                 315                 320 


Lys Leu Pro Glu Lys Lys Phe Thr Gly Leu Ala Lys Asp Leu Tyr Arg 
                325                 330                 335     


Ala Ile Phe Phe Gln Arg Pro Leu Lys Ser Gln Lys Gly Leu Ile Gly 
            340                 345                 350         


Lys Cys Ser Phe Glu Lys Asn Lys Ser Arg Cys Ala Val Ser His Pro 
        355                 360                 365             


Asp Tyr Glu Glu Phe Arg Met Trp Ser Tyr Leu Asn Thr Ile Lys Ile 
    370                 375                 380                 


Gly Thr Gln Ser Glu Lys Thr Leu Arg Phe Leu Thr Leu Glu Glu Lys 
385                 390                 395                 400 


Leu Lys Leu Val Pro Lys Phe Tyr Arg Lys Ser Asp Phe Asn Phe Glu 
                405                 410                 415     


Val Leu Ala Lys Glu Leu Val Glu Lys Gly Ala Ser Phe Gly Tyr Tyr 
            420                 425                 430         


Lys Ser Ser Lys Lys Asn Glu Phe Phe Tyr Trp Phe Asn Tyr Lys Pro 
        435                 440                 445             


Thr Asp Ser Val Ser Ala Cys Val Val Ser Ala Ser Leu Glu Asn Ala 
    450                 455                 460                 


Ile Gly Lys Asp Trp Lys Ile Lys Thr Phe Glu Tyr Gln Thr Arg Asn 
465                 470                 475                 480 


Thr Glu Lys Asn Glu Val Thr Lys Ser Val Asp Tyr Lys Asp Leu Trp 
                485                 490                 495     


His Leu Leu Ser Val Ala Thr Ser Asp Thr Tyr Leu Tyr Asp Phe Ala 
            500                 505                 510         


Ile Glu Lys Leu Lys Leu Glu Pro Lys Asn Ala Lys Ala Phe Ser Lys 
        515                 520                 525             


Thr Lys Leu Lys Lys Asp Phe Ala Ser Leu Ser Leu Ala Ala Ile Ala 
    530                 535                 540                 


Lys Ile Leu Pro Tyr Leu Lys Gln Gly Leu Leu Tyr Ser His Ala Val 
545                 550                 555                 560 


Phe Met Ala Asn Ile Glu Asn Ile Val Asp Ala Asp Ile Trp Lys Asp 
                565                 570                 575     


Glu Glu Gln Gln Lys Phe Ile Gln Ser Lys Ile Val Glu Leu Val Asp 
            580                 585                 590         


Asn Tyr Ile Val Glu Lys Ser Lys Leu Glu Leu Ile Asn Gly Leu Leu 
        595                 600                 605             


Lys Ile Tyr Asn Thr Glu Asp Lys Glu Gly Arg Lys Val Tyr Tyr Ser 
    610                 615                 620                 


Lys Glu Ala Glu Ser Leu Phe Glu Ala Asp Leu Arg Lys Lys Leu Val 
625                 630                 635                 640 


Pro Phe Tyr Lys Ala Asn Ile Ile Ile Glu Glu His Glu Gln Glu Ile 
                645                 650                 655     


Ile Phe Gln Asp Leu Phe Pro Ile Leu Met Asp Gln Leu Lys Lys Gln 
            660                 665                 670         


Glu Phe Ile Lys Ile Gly Arg Leu Asp Lys Gln Ile Glu Ala Phe Leu 
        675                 680                 685             


Glu Gly Glu Asn Glu Glu Gly Gln Ile Phe Cys Asn His Thr Asp Lys 
    690                 695                 700                 


Leu Lys Lys Leu Tyr His Pro Ser Asp Ile Glu Val Phe Lys Lys Lys 
705                 710                 715                 720 


Thr Ile Lys Asp Glu Trp Gly Asn Glu Lys Val Val Leu Gly Ser Pro 
                725                 730                 735     


Leu Thr Thr Ser Ile Lys Asn Pro Met Ala Met Arg Ala Leu His Gln 
            740                 745                 750         


Leu Arg Lys Val Leu Asn Thr Leu Ile Ala Asn Asp Gln Ile Asp Glu 
        755                 760                 765             


Asp Thr Arg Ile His Ile Glu Met Ala Arg Glu Leu Asn Asp Ala Asn 
    770                 775                 780                 


Lys Arg Lys Gly Ile Gln Asp Phe Gln Asn Glu Asn Lys Lys Phe Arg 
785                 790                 795                 800 


Glu Glu Ala Ile Lys Glu Ile Lys Lys Leu Tyr Leu Glu Glu Cys His 
                805                 810                 815     


Lys Asp Val Asn Pro Thr Glu Asp Asp Ile Leu Arg Tyr Gln Leu Trp 
            820                 825                 830         


Leu Glu Gln Gly Lys Cys Glu Ile Tyr Glu Glu Gly Asn Asn Ile Ser 
        835                 840                 845             


Ile Cys Asp Ile Ile Gly Ser Asn Pro Ser Tyr Asp Ile Glu His Thr 
    850                 855                 860                 


Ile Pro Arg Ser Ile Ser Gln Asp Asn Ser Gln Met Asn Lys Thr Leu 
865                 870                 875                 880 


Cys Ser Leu Lys Phe Asn Arg Ser Ile Lys Lys Gln Lys Met Pro Val 
                885                 890                 895     


Glu Leu Ser Asn Tyr Asn Asp Ile Leu Pro Arg Ile Ala His Trp Lys 
            900                 905                 910         


Lys Glu Ala Glu Glu Leu Thr Arg Gln Ile Glu Thr Ile Ser Arg Ser 
        915                 920                 925             


Ile Lys Ser Ala Ala Thr Lys Val Ala Lys Asp Lys Asn Ile Arg Lys 
    930                 935                 940                 


Arg His Tyr Leu Thr Leu Lys Arg Asp Tyr Ile Leu Gly Lys Tyr Glu 
945                 950                 955                 960 


Arg Phe Thr Trp Glu Glu Pro Lys Val Gly Phe Lys Asn Ser Gln Ile 
                965                 970                 975     


Pro Asp Thr Gly Ile Ile Thr Lys Tyr Ala Gln Ala Tyr Leu Lys Ser 
            980                 985                 990         


Tyr Phe Lys Arg Val Glu Ser Val  Lys Gly Gly Ala Val  Ala Glu Phe 
        995                 1000                 1005             


Arg Lys  Leu Trp Gly Ile Gln  Glu Ser Phe Ile Asp  Glu Asn Trp 
    1010                 1015                 1020             


Trp Lys  His Tyr Lys Asp Lys  Asp Arg Asp Lys His  Thr His His 
    1025                 1030                 1035             


Thr Ile  Asp Ala Ile Thr Ile  Ala Cys Met Pro Lys  Asp Lys Tyr 
    1040                 1045                 1050             


Asp Leu  Leu Ala His Ala Trp  Arg Leu Glu Asp Glu  Gln Asp Lys 
    1055                 1060                 1065             


Lys Ala  Ala Lys Val Leu Ile  Glu Gln Ala Lys Pro  Trp Lys Thr 
    1070                 1075                 1080             


Phe Lys  Glu Asp Ile Glu Lys  Ile Glu Thr Glu Ile  Leu Val Ser 
    1085                 1090                 1095             


His Phe  Thr Pro Asp Asn Val  Lys Lys Gln Ser Lys  Ser Ile Ile 
    1100                 1105                 1110             


Lys Asn  Arg Gly Lys Lys Val  Tyr Val Leu Lys Asn  Glu Leu Pro 
    1115                 1120                 1125             


Val Asn  Phe Lys Asn Lys Ile  Glu Gly Lys Asp Tyr  Phe Lys Leu 
    1130                 1135                 1140             


Lys Phe  Asp Ser Lys Ile Leu  Tyr Lys Ile Pro Lys  Lys Lys Glu 
    1145                 1150                 1155             


Lys Gln  Thr Asp Thr Phe Tyr  Glu Glu Leu Pro Lys  Asn Tyr Leu 
    1160                 1165                 1170             


Asn Gly  Val Glu Gly Lys Asp  Tyr Phe Lys Ile Asn  Thr Thr Gly 
    1175                 1180                 1185             


Lys Thr  Phe Tyr Lys Ile Pro  Ile Phe Asn Gln Gly  Asp Thr Ile 
    1190                 1195                 1200             


Arg Gly  Ser Leu His Gln Glu  Thr Thr Tyr Gly Ala  Ile Lys Leu 
    1205                 1210                 1215             


Pro Asp  Ile Asp Ile Glu Thr  Lys Lys Pro Leu His  Thr Asp Lys 
    1220                 1225                 1230             


Gly Gly  Phe Ile Leu Lys Lys  Asp Ile Lys Gly Asn  Glu Ile Val 
    1235                 1240                 1245             


Phe Phe  Val Val Arg Lys Glu  Ile Ser Lys Ile Ser  Glu Asn Asp 
    1250                 1255                 1260             


Val Gln  Asn Ile Val Asp Asn  Val Val Arg Lys Lys  Ile Glu Asn 
    1265                 1270                 1275             


Ala Ile  Ala Asn Ser Leu Ile  Thr Phe Lys Ile Val  Lys Lys Lys 
    1280                 1285                 1290             


Lys Val  Ala Val Ile Lys Glu  Gly Val Thr Ile Trp  Met Arg Glu 
    1295                 1300                 1305             


Pro Asn  Ile Glu Lys Gly Ile  Glu Gly Ile Pro Ile  Lys Lys Val 
    1310                 1315                 1320             


Arg Ile  Ile Thr Asn Ser Val  Lys Asn Pro Ile Glu  Ile Lys Val 
    1325                 1330                 1335             


His Ser  Pro Leu Ser Lys Ser  Arg His Lys His Lys  Gln Lys Val 
    1340                 1345                 1350             


Tyr Gly  Gln Asn Asp Glu Asn  Tyr Ala Met Ala Leu  Tyr Glu Leu 
    1355                 1360                 1365             


Asp Gly  Lys Arg Glu Phe Glu  Leu Ile Asn Asn Phe  Asn Leu Ala 
    1370                 1375                 1380             


Lys Leu  Leu Lys Gln Ser Gln  Ser Tyr Tyr Pro Leu  His Lys Glu 
    1385                 1390                 1395             


Lys Glu  Ile Lys Gly Lys Lys  Ile Leu Val Pro Ile  Glu Lys Arg 
    1400                 1405                 1410             


Asn Asn  Lys Asp Val Ile Leu  Lys Arg Gly Gln Gln  Val Val Phe 
    1415                 1420                 1425             


Tyr Asp  Lys Thr Val Glu Asn  Pro Lys Asp Ile Ser  Glu Ile Ile 
    1430                 1435                 1440             


Asp Phe  Arg Glu Arg Ile Tyr  Ile Ile Glu Gly Leu  Thr Ile Gln 
    1445                 1450                 1455             


Arg Gln  Lys Asp Lys Lys Thr  Ser Lys Val Asn Glu  Tyr Gly Ile 
    1460                 1465                 1470             


Ile Gln  Leu Arg His Phe Lys  Glu Ala Arg Lys Ser  Glu Glu Ile 
    1475                 1480                 1485             


Ser Lys  Asp Asn Phe Lys Pro  Asp Gly Glu Phe Lys  Ile Asn Glu 
    1490                 1495                 1500             


Asn Lys  Pro Thr Arg Lys Met  Asn His Asn Gln Phe  Thr Ala Phe 
    1505                 1510                 1515             


Val Glu  Gly Ile Asp Phe Lys  Val Leu Pro Ser Gly  Lys Phe Gln 
    1520                 1525                 1530             


Lys Ile  
    1535 


<210> 224
<211> 1354
<212> PRT
<213> Flavobacterium psychrophilum


<220>
<223> Flavobacterium psychrophilum JIP02/86

<400> 224
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ile Asn Glu Ala Glu Asn Glu Ile Glu Val Ser Ser Ile Val 
            20                  25                  30          


Asn Thr Gly Val Arg Ile Val Pro Leu Thr Thr Asp Glu Glu Ser Asp 
        35                  40                  45              


Phe Lys Lys Gly Asn Thr Ile Ser Ile Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Ala Arg Arg Gly Leu Gln Arg Phe Lys Gln Arg Arg Glu Ala 
65                  70                  75                  80  


Leu Leu Glu Thr Phe Asn Arg Ile Lys Phe Ile Ala Thr Asp Phe Val 
                85                  90                  95      


Tyr Ala Glu Thr Gly Ala Ala Thr Thr Phe Ser Ser Tyr Gln Leu Arg 
            100                 105                 110         


Ala Lys Ser Ala Val Glu Ala Val Thr Lys Glu Glu Leu Val Lys Val 
        115                 120                 125             


Leu Leu Met Leu Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Thr Ala Glu Glu Gly Asp Ala Ile Asp Gly Met Lys Ile Ala Lys 
145                 150                 155                 160 


Glu Ile Phe Glu Asn Asn Leu Thr Pro Gly Gln Trp Val Tyr Asn Ser 
                165                 170                 175     


Leu Ser Lys Gly Gly Lys Phe Ile Pro Asp Phe Tyr His Ser Asp Leu 
            180                 185                 190         


Gln Lys Glu Leu Glu Lys Ile Val Arg Phe Gln Asn Gln Phe His Ser 
        195                 200                 205             


Glu Gln Ile Asn Asp Lys Leu Leu Ala Asp Ile Gln Gly Lys Ser Arg 
    210                 215                 220                 


Thr Gln Thr Ser Gln His Phe Ser Lys Thr Leu Asn Ile Pro Leu Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Thr Arg Glu Glu Thr Lys Leu Gln His Tyr Gln Trp 
                245                 250                 255     


Arg Asn Glu Ala Leu Ala Asn Glu Leu Asp Met Lys Ile Leu Ala Phe 
            260                 265                 270         


Ile Ile Thr Glu Ile Asn Asn Gln Ile Asn Gln Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Gln Glu Thr 
    290                 295                 300                 


Val Gly Gln Tyr Gln Tyr Lys Gln Leu Gln Glu Asn Val His Ala Lys 
305                 310                 315                 320 


Leu Lys Asn Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Lys Ile Trp Glu Thr Gln Ala Lys Phe His Ser Glu Leu Asn Glu Lys 
            340                 345                 350         


Leu Lys Ala Glu Ile Arg Asp Ile Thr Ile Phe Tyr Gln Arg Lys Leu 
        355                 360                 365             


Lys Ser Gln Lys His Leu Val Ser Phe Cys Glu Phe Glu Lys Gly His 
    370                 375                 380                 


Lys Ala Ile Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Arg Ile Trp 
385                 390                 395                 400 


Gln Asn Leu Asn Asn Val Val Val Lys Asn Glu Thr Thr Lys Glu Val 
                405                 410                 415     


Phe Glu Leu Ser Glu Glu Leu Lys Gln Leu Ile Ala Glu Glu Leu Gln 
            420                 425                 430         


Phe Lys Glu Ser Met Thr Asp Val Gln Met Leu Thr Phe Cys Glu Leu 
        435                 440                 445             


Lys Lys Gly Thr His Thr Val Asn Phe Lys Lys Ile Glu Gly Asn Arg 
    450                 455                 460                 


Thr Asn Thr Ser Ile Tyr Lys Ala Phe Glu Lys Ile Leu Glu Val Glu 
465                 470                 475                 480 


Gly Tyr Glu Ile Asp Phe Ser Lys Met Lys Pro Leu Glu Ile Lys Glu 
                485                 490                 495     


Thr Val Ala Pro Ile Phe Glu Thr Leu Asn Ile Asn Thr Val Ile Leu 
            500                 505                 510         


Asp Phe Asp Pro Thr Ile Gln Gly Asn Asp Phe Asp Lys Gln Pro Tyr 
        515                 520                 525             


Tyr Gln Leu Trp His Leu Leu Tyr Ser Ala Glu Asp Asp Asp Lys Leu 
    530                 535                 540                 


Lys Glu Thr Leu Lys Thr Lys Phe Gly Phe Lys Glu Asn His Leu Pro 
545                 550                 555                 560 


Phe Ile Leu Asn Ile Asn Leu Gln Ala Asp Tyr Gly Ser Leu Ser Ala 
                565                 570                 575     


Lys Ala Ile Lys Lys Ile Leu Pro His Leu Met Asp Gly His Ile Tyr 
            580                 585                 590         


Asp Lys Ala Cys Leu Met Val Gly Tyr Asn His Ser Ser Ser Leu Thr 
        595                 600                 605             


Thr Ala Gln Asn Asn Asp Arg Val Leu Lys Asp Thr Leu Glu Leu Leu 
    610                 615                 620                 


Lys Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Leu Asn Gln 
625                 630                 635                 640 


Met Ile Asn Val Ile Asn Ala Ile Met Lys Asp Pro Ala Met Gly Lys 
                645                 650                 655     


Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys Ala Asn Asn 
            660                 665                 670         


Glu Gln Arg Lys Lys Ala Thr Ser Asp Ile Asn Thr Ala Thr Thr Glu 
        675                 680                 685             


His Glu Arg Ile Arg Lys Leu Leu His Ser Glu Phe Asn Ile Pro Arg 
    690                 695                 700                 


Val Thr Arg Asn Asp Ile Ile Arg Tyr Lys Leu Trp Leu Glu Thr Gly 
705                 710                 715                 720 


Gly Ile Ser Leu Tyr Thr Gly Asn Pro Ile Lys Ala Ser Asp Leu Phe 
                725                 730                 735     


Ser Lys Asn Tyr Asp Ile Glu His Ile Ile Pro Lys Ser Arg Leu Phe 
            740                 745                 750         


Asp Asp Ser Phe Ser Asn Lys Thr Leu Cys Glu Arg Gln Leu Asn Ile 
        755                 760                 765             


Asp Lys Ser Asn Lys Thr Ala Tyr Ser Phe Leu Gln Glu Lys Leu Ser 
    770                 775                 780                 


Glu Asn Asp Phe Ala Ala Tyr Glu Asn Arg Val Lys Asp Leu Phe Lys 
785                 790                 795                 800 


Thr Gly Lys Ile Lys Ser Tyr Thr Lys Tyr Lys Lys Leu Leu Met Ala 
                805                 810                 815     


Asp Asn Glu Ile Pro Glu Gly Phe Ile Asp Arg Gln Leu Arg Glu Thr 
            820                 825                 830         


Gln Tyr Ile Ala Lys Lys Ala Lys Glu Ile Leu Leu Glu Val Ser Arg 
        835                 840                 845             


Asn Val Thr Ala Thr Ile Gly Ser Val Thr Asp Lys Leu Arg Gln Asp 
    850                 855                 860                 


Trp Glu Leu Val Asp Val Met Lys Glu Leu Asn Trp Glu Lys Tyr Asp 
865                 870                 875                 880 


Lys Leu Gly Leu Thr His Ile Glu Glu Gly Lys Asn Gly Glu Arg Leu 
                885                 890                 895     


Ser Lys Ile Lys Asp Trp Thr Lys Arg Asn Asp His Arg His His Ala 
            900                 905                 910         


Met Asp Ala Ile Thr Val Ala Phe Thr Lys Pro Ala Tyr Ile Gln Tyr 
        915                 920                 925             


Leu Asn Asn Leu Asn Ala Lys Thr Gln Gly Glu Asn Lys Ala Asn Ser 
    930                 935                 940                 


Ile Ile Gly Ile Glu Asn Lys His Leu Tyr Arg Asp Lys Asn Asn Lys 
945                 950                 955                 960 


Leu Arg Phe Ile Ser Pro Met Lys Asn Phe Arg Glu Glu Ala Lys Lys 
                965                 970                 975     


Gln Leu Glu Ser Ile Leu Ile Ser Tyr Lys Ala Lys Asn Lys Val Val 
            980                 985                 990         


Thr Lys Asn Lys Asn Thr Thr Lys  Lys Ser Gly Gly Thr  Asn Gln Lys 
        995                 1000                 1005             


Ile Gln  Leu Thr Pro Arg Gly  Arg Leu His Lys Glu  Thr Val Tyr 
    1010                 1015                 1020             


Gly Lys  Leu Gln Gln Tyr Ala  Thr Lys Glu Glu Lys  Val Asn Ala 
    1025                 1030                 1035             


Ser Phe  Thr Glu Asp Tyr Ile  Gln Lys Val Ala Lys  Lys Glu Tyr 
    1040                 1045                 1050             


Arg Glu  Ala Leu Leu Lys Arg  Leu Glu Glu Asn Asp  Asn Asp Pro 
    1055                 1060                 1065             


Lys Lys  Ala Phe Thr Gly Lys  Asn Ala Leu Asn Lys  Thr Pro Ile 
    1070                 1075                 1080             


Tyr Ile  Ser Leu Lys Asp Asn  Ile Ile Val Pro Glu  Lys Val Lys 
    1085                 1090                 1095             


Thr Val  Trp Leu Glu Thr Asp  Tyr Thr Ile Arg Lys  Asp Ile Thr 
    1100                 1105                 1110             


Pro Asp  Leu Lys Ile Asp Lys  Val Ile Asp Val Gly  Ile Lys Arg 
    1115                 1120                 1125             


Ile Leu  Gln Asn Arg Leu Asn  Glu Phe Asn Gly Asp  Pro Lys Lys 
    1130                 1135                 1140             


Ala Phe  Val Asn Leu Gly Glu  Ser Pro Ile Trp Leu  Asn Lys Glu 
    1145                 1150                 1155             


Lys Gly  Ile Ala Ile Lys Arg  Val Thr Ile Ser Gly  Val Ser Asn 
    1160                 1165                 1170             


Ala Gln  Ala Leu His Thr Lys  Lys Asp His Leu Gly  Asn Glu Ile 
    1175                 1180                 1185             


Leu Asp  Lys Asn Gly Asn Pro  Ile Pro Val Asp Phe  Ile Ser Thr 
    1190                 1195                 1200             


Gly Asn  Asn His His Val Ala  Ile Tyr Arg Asp Glu  Lys Gly Asn 
    1205                 1210                 1215             


Leu Gln  Glu Glu Val Val Ser  Phe Tyr Asp Ala Val  Ile Arg Arg 
    1220                 1225                 1230             


Asn Leu  Gly Leu Ser Val Ile  Asn Lys Asn His Glu  Lys Gly Trp 
    1235                 1240                 1245             


Glu Phe  Leu Phe Ser Met Lys  Gln Asn Glu Phe Phe  Ile Phe Pro 
    1250                 1255                 1260             


Ser Asp  Gly Phe Asn Pro His  Glu Ile Asp Leu Leu  Asn Pro Asn 
    1265                 1270                 1275             


Asn Tyr  His Leu Ile Ser Pro  Asn Ile Phe Arg Val  Gln Lys Ile 
    1280                 1285                 1290             


Ser Thr  Lys Asn Tyr Met Phe  Asn His His Leu Glu  Thr Lys Ala 
    1295                 1300                 1305             


Val Asp  Gly Glu Met Leu Lys  Ser Lys Lys Glu Leu  Ser Lys Thr 
    1310                 1315                 1320             


Ser Tyr  His Phe Ile Gln Thr  Pro Thr Asn Leu Asn  Gly Ile Ile 
    1325                 1330                 1335             


Lys Val  Arg Ile Asn His Leu  Gly Lys Ile Val His  Leu Gly Glu 
    1340                 1345                 1350             


Tyr 
    


<210> 225
<211> 1458
<212> PRT
<213> Fluviicola taffensis

<400> 225
Met Thr Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly 
1               5                   10                  15      


Trp Ala Leu Ile Asn Gln Asp Phe Asp Asn Lys Lys Gly Glu Ile Leu 
            20                  25                  30          


Gly Met Gly Ser Arg Ile Ile Pro Met Thr Gln Asp Ile Lys Asp Glu 
        35                  40                  45              


Phe Gly Lys Gly Asn Ser Ile Ser Gln Thr Ala Glu Arg Thr Arg Leu 
    50                  55                  60                  


Arg Gly Val Arg Arg Leu Ile His Arg Thr Leu Leu Arg Arg Glu Arg 
65                  70                  75                  80  


Leu His Arg Val Leu Asn Ile Ile Gly Phe Leu Pro Glu His Tyr Ala 
                85                  90                  95      


Asn Gln Ile Asp Phe Glu Lys Arg Phe Gly Lys Phe Lys Pro Glu Ser 
            100                 105                 110         


Glu Pro Lys Ile Ser Phe Asp Gly Asn Asp Val Phe Leu Phe Glu Lys 
        115                 120                 125             


Ser Tyr Gln Glu Met Leu Val Asp Phe Lys Ile His Gln Pro Gln Leu 
    130                 135                 140                 


Val Ser Asn Gly Lys Lys Ile Pro His Asp Trp Thr Ile Tyr Tyr Leu 
145                 150                 155                 160 


Arg Lys Lys Ala Leu Ser Lys Lys Ile Glu Lys Glu Glu Leu Ala Trp 
                165                 170                 175     


Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg Gly 
            180                 185                 190         


Glu Glu Glu Glu Glu Thr Pro Asn Lys Leu Val Glu Phe His Ser Leu 
        195                 200                 205             


Lys Ile Val Glu Val Asn Ala Asp Glu Pro Gln Lys Gly Lys Pro Glu 
    210                 215                 220                 


Ile Trp Tyr Ser Leu Val Leu Glu Asn Gly Trp Val Tyr Arg Arg Ala 
225                 230                 235                 240 


Ser Lys Thr Pro Leu Phe Asp Trp Lys Asp Lys Ile Arg Glu Phe Ile 
                245                 250                 255     


Val Thr Thr Glu Ile Asn Asn Asp Gly Thr Val Lys Thr Asp Lys Glu 
            260                 265                 270         


Gly Thr Glu Lys Arg Ser Phe Arg Ala Pro Lys Pro Glu Asp Trp Thr 
        275                 280                 285             


Leu Gln Lys Lys Lys Thr Glu Phe Glu Leu Ser Lys Ser Gly Asn Glu 
    290                 295                 300                 


Val Gly Ala Phe Ile Tyr Glu Ser Ile Leu Gln Lys Pro Asn Gln Lys 
305                 310                 315                 320 


Ile Arg Gly Lys Leu Ile Ser Thr Ile Glu Arg Lys Phe Tyr Lys Glu 
                325                 330                 335     


Glu Leu Lys Thr Ile Leu Lys Thr Gln Leu Phe Phe His Lys Glu Leu 
            340                 345                 350         


Lys Asp Glu Lys Leu Tyr Asn Ala Cys Ile Glu Glu Leu Tyr Lys Asn 
        355                 360                 365             


Asn Glu Ala His Arg Ser Leu Leu Ser Asn Lys Gly Phe Glu His Leu 
    370                 375                 380                 


Phe Ile Asn Asp Ile Leu Phe Tyr Gln Arg Pro Leu Arg Ser Lys Lys 
385                 390                 395                 400 


Ser Gln Ile Ser Asn Cys Pro Leu Glu Lys Arg Thr Tyr Lys Lys Glu 
                405                 410                 415     


Gly Ile Glu Ile Thr Glu Gly Ile Lys Val Ile Ser Lys Ser Asn Pro 
            420                 425                 430         


Ile Tyr Gln Glu Phe Arg Leu Trp Gln Trp Ile Ser Asn Leu Ser Leu 
        435                 440                 445             


Tyr Cys Ile Glu Pro Thr Glu Thr Asn Val Thr Ser Thr Phe Leu Asn 
    450                 455                 460                 


Ser Ile Glu Asp Tyr Glu Asn Leu Phe Glu Phe Leu Asn Asn Arg Lys 
465                 470                 475                 480 


Glu Ile Glu Gln Lys His Leu Leu Lys Tyr Leu Leu Glu Asn Gln Gly 
                485                 490                 495     


Phe Lys Gly Lys Leu Leu Thr Asn Glu Leu Glu Lys Phe Arg Trp Asn 
            500                 505                 510         


Phe Val Ala Asp Lys Lys Tyr Pro Cys Asn Glu Thr Gly Ser Leu Leu 
        515                 520                 525             


His Thr Arg Leu Ser Lys Val Lys Asn Ile Ser Pro Asp Phe Leu Thr 
    530                 535                 540                 


Lys Glu Ile Glu His Gln Leu Trp His Ile Ile Tyr Ser Val Thr Asp 
545                 550                 555                 560 


Lys Ile Glu Tyr Glu Gln Ala Leu Lys Thr Phe Ala Arg Lys Asn Asn 
                565                 570                 575     


Leu Asp Val Asp Ser Phe Phe Glu His Phe Lys Lys Ile Pro Pro Phe 
            580                 585                 590         


Glu Ser Thr Tyr Gly Ala Tyr Ser Glu Lys Ala Ile Lys Lys Leu Leu 
        595                 600                 605             


Pro Leu Ile Arg Leu Gly Lys Tyr Trp Asn Trp Glu Ala Ile Asp Ser 
    610                 615                 620                 


Ile Ser Lys Asp Arg Ile Ser Lys Ile Leu Ser Gly Glu Tyr Asp Glu 
625                 630                 635                 640 


Asn Ile Lys Asn Arg Val Arg Glu Lys Ala Val His Leu Thr Ser Glu 
                645                 650                 655     


Asn Asn Phe Gln Gly Leu Gln Glu Trp Leu Ala Lys Tyr Ile Val Tyr 
            660                 665                 670         


Asp Arg His Ser Glu Gly Asn Asp Leu Gly Lys Trp Thr Ser Val Ser 
        675                 680                 685             


Asp Leu Glu Thr Tyr Leu Lys Glu Phe Lys Gln His Ser Leu Arg Asn 
    690                 695                 700                 


Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val Val Lys Asp 
705                 710                 715                 720 


Ile Trp Ile Lys His Gly Lys Gly Thr Glu Asn Phe Phe Asp Glu Ile 
                725                 730                 735     


His Val Glu Leu Gly Arg Glu Met Lys Asn Asn Ser Glu Asp Arg Lys 
            740                 745                 750         


Arg Leu Thr Asn Thr Ile Thr Glu Asn Glu Asn Thr Asn Leu Arg Ile 
        755                 760                 765             


Lys Ala Leu Leu Met Glu Met Met Asn Asp Asn Asp Val Glu Asn Val 
    770                 775                 780                 


Arg Pro Tyr Ser Pro Ser Gln Gln Glu Ile Leu Lys Ile Tyr Glu Asp 
785                 790                 795                 800 


Gly Ala Leu Asn Ser Asn Ile Glu Leu Asp Asp Glu Ile Val Lys Ile 
                805                 810                 815     


Ser Lys Lys Ala Glu Pro Thr Lys Ser Glu Leu Gln Arg Tyr Lys Leu 
            820                 825                 830         


Trp Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Gln Val Ile Pro 
        835                 840                 845             


Leu Asn Lys Leu Phe Thr Ser Glu Tyr Glu Ile Glu His Val Val Pro 
    850                 855                 860                 


Gln Ser Arg Phe Phe Asp Asp Ser Phe Ser Asn Lys Val Ile Cys Glu 
865                 870                 875                 880 


Ser Ala Val Asn Lys Arg Lys Asp Asn Gln Leu Gly Leu Gln Phe Ile 
                885                 890                 895     


Lys Asn His Ser Gly Glu Lys Val Glu Leu Gly Phe Gly Lys Val Val 
            900                 905                 910         


Gln Val Phe Thr Glu Glu Gln Tyr Leu Asp Phe Val Lys Glu His Tyr 
        915                 920                 925             


Ser Lys Asn Arg Ser Lys His Asn Lys Leu Leu Leu Glu Glu Ile Pro 
    930                 935                 940                 


Glu Lys Met Ile Glu Arg Gln Leu Asn Asp Thr Arg Tyr Ile Ser Lys 
945                 950                 955                 960 


Phe Val Ser Ser Ile Leu Ser Asn Ile Val Arg Ser Glu Lys Asp Asp 
                965                 970                 975     


Asp Gly Leu Asn Ser Lys Asn Ile Leu Pro Gly Asn Gly Lys Ile Thr 
            980                 985                 990         


Thr Glu Leu Lys Arg Asp Trp Gly  Leu Asn Asp Val Trp  Asn Asp Leu 
        995                 1000                 1005             


Ile Leu  Pro Arg Phe Glu Arg  Met Asn Thr Ile Thr  Asn Ser Asp 
    1010                 1015                 1020             


Leu Phe  Thr Thr Tyr Asn Asp  Lys Tyr Gln Lys His  Leu Pro Thr 
    1025                 1030                 1035             


Val Pro  Phe Glu Tyr Ser Lys  Gly Phe Gln Lys Lys  Arg Ile Asp 
    1040                 1045                 1050             


His Arg  His His Ala Met Asp  Ala Leu Val Ile Ala  Cys Ala Thr 
    1055                 1060                 1065             


Arg Asp  His Leu Asn Leu Met  Asn Asn Gln Ser Ala  Lys Ser Glu 
    1070                 1075                 1080             


Leu Lys  Arg Tyr Asp Leu Gln  Asn Lys Leu Arg Lys  Lys Glu Pro 
    1085                 1090                 1095             


Tyr Phe  Asn Gln Lys Glu Asn  Lys Gln Lys Glu Ala  Phe Lys Asp 
    1100                 1105                 1110             


Phe Ile  Lys Pro Trp Gly Thr  Phe Thr Glu Asp Ser  Lys Asn Ala 
    1115                 1120                 1125             


Leu Glu  Lys Ile Ile Ile Ser  Phe Lys Gln Asn Leu  Arg Val Ile 
    1130                 1135                 1140             


Asn Lys  Ala Thr Asn Ser Tyr  Glu Ser Tyr Lys Asp  Glu Asp Gly 
    1145                 1150                 1155             


Asn Leu  Arg Ile Gly Lys Asp  Gly Lys Pro Glu Lys  Gly Leu Ile 
    1160                 1165                 1170             


Lys Gln  Lys Gly Leu Asn Trp  Ala Ile Arg Lys Pro  Leu His Lys 
    1175                 1180                 1185             


Asp Thr  Val Ser Gly Gln Ile  Asn Leu Ser Arg Ile  Lys Leu Pro 
    1190                 1195                 1200             


Asn Gly  Lys Ile Leu Thr Ala  Thr Arg Lys Asn Leu  Asp Thr Ser 
    1205                 1210                 1215             


Phe Asp  Leu Lys Thr Ile Glu  Asn Ser Ile Thr Asp  Thr Gly Ile 
    1220                 1225                 1230             


Gln Lys  Ile Leu Lys Asn Tyr  Leu Leu Ser Lys Glu  Ser Pro Glu 
    1235                 1240                 1245             


Leu Ala  Phe Ser Pro Glu Gly  Leu Glu Glu Met Asn  Asn Glu Ile 
    1250                 1255                 1260             


Glu Lys  Tyr Asn Asn Gly Lys  Phe His His Pro Ile  Asn Lys Ala 
    1265                 1270                 1275             


Arg Ile  Tyr Glu Leu Gly Ser  Lys Phe Asn Val Gly  Gln Thr Gly 
    1280                 1285                 1290             


Asn Arg  Arg Asp Lys Phe Val  Glu Ala Ala Lys Gly  Thr Asn Leu 
    1295                 1300                 1305             


Phe Phe  Ala Ile Tyr Gln Asp  Glu Asn Lys Asn Arg  Ser Tyr Glu 
    1310                 1315                 1320             


Thr Ile  Pro Leu Asn Glu Val  Ile Glu His Gln Lys  Trp Arg Ala 
    1325                 1330                 1335             


Ser Leu  Pro Lys Glu Glu Gln  Glu Lys Ile Pro Leu  Val Pro Val 
    1340                 1345                 1350             


Asn Lys  Leu Lys Gly Thr Phe  Ile Phe Ser Leu Ser  Pro Asn Asp 
    1355                 1360                 1365             


Leu Val  Tyr Val Pro Ser Asn  Asp Glu Leu Glu Arg  Ser Ala Ser 
    1370                 1375                 1380             


Ile Asp  Phe Ser Lys Leu Lys  Lys Glu Gln Ile Asn  Arg Leu Tyr 
    1385                 1390                 1395             


Lys Met  Val Ser Ser Ser Gly  Ser Gln Cys Phe Phe  Val Lys Ser 
    1400                 1405                 1410             


Glu Val  Ala Thr Ser Val Val  Asn Lys Met Glu Tyr  Ser Ser Leu 
    1415                 1420                 1425             


Asn Lys  Met Glu Lys Ser Ile  Asp Asn Leu Met Val  Lys Glu Ile 
    1430                 1435                 1440             


Cys Ile  Lys Leu Lys Ile Asp  Arg Leu Gly Asn Ile  Ser Lys Ala 
    1445                 1450                 1455             


<210> 226
<211> 1646
<212> PRT
<213> Francisella tularensis

<400> 226
Met Asn Ile Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Ala Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Ser 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Lys Gln Leu Asn Leu Glu Trp Asn Lys Asp Thr Gln Gln Thr Ile Ser 
                85                  90                  95      


Phe Leu Leu Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Ala Pro Glu Ala Val Lys Ala Ile Leu Met 
        115                 120                 125             


Ser Ile Leu Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Gln Ser Ala Thr Glu Asn Asp Ser Lys Ile Asp Glu Leu Tyr Asn Lys 
145                 150                 155                 160 


Leu Leu Gln Lys Ala Leu Glu Phe Lys Leu Arg Lys Leu Cys Ile Asp 
                165                 170                 175     


Ile Lys Glu Asp Lys Val Thr Thr Lys Thr Leu Lys Glu Leu Ser Asn 
            180                 185                 190         


Thr Glu Phe Lys Leu Leu Ala Asn Tyr Leu Val Asp Tyr Asp Arg Ile 
        195                 200                 205             


Leu Arg Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Arg 
    210                 215                 220                 


Glu Leu Asn Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg Asn Ile Ile Ile Asn Asp Val Ile Leu Glu Lys Leu Thr Asp 
                245                 250                 255     


Asp Leu Asp Ile Trp Asn Leu Asn Phe Asp Lys Phe Asp Phe Glu Lys 
            260                 265                 270         


Asn Leu Glu Lys Leu Glu Asn Gln Glu Asp Lys Asp Tyr Leu Gln Thr 
        275                 280                 285             


His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met 
    290                 295                 300                 


Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn 
305                 310                 315                 320 


Val Leu Val Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys 
                325                 330                 335     


Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu 
            340                 345                 350         


Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg 
        355                 360                 365             


Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp Tyr Trp Asp Glu 
    370                 375                 380                 


Gln Lys Phe Ala Glu Thr Tyr Ser Asp Trp Ile Leu Gly Glu Trp Arg 
385                 390                 395                 400 


Val Gly Ala Lys Asp Lys Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr 
                405                 410                 415     


Lys Asn Leu Cys Asp Glu Leu Lys Gln Lys Val Gly Ile Asn Gln Asp 
            420                 425                 430         


Gly Ile Ile Asn Gln Thr Lys Ser Asp Phe Val Asp Phe Leu Leu Glu 
        435                 440                 445             


Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg 
    450                 455                 460                 


Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp 
465                 470                 475                 480 


Asn Lys Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu 
                485                 490                 495     


Gln Thr Val Gln Asn Tyr Leu Gly Asn Phe Glu Ile Asp Leu Lys Asp 
            500                 505                 510         


Leu Lys Ser Ser Lys Glu Gln Pro Tyr Phe Val Lys Tyr Lys Ser Leu 
        515                 520                 525             


Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala 
    530                 535                 540                 


Arg Val Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu Leu 
545                 550                 555                 560 


Leu Leu Asn Glu Ile Tyr Ser His Ala Lys Lys Leu Lys Gln Asn Thr 
                565                 570                 575     


Ser Ser Glu Leu Glu Lys Leu Glu Leu Cys Lys Lys Leu Asp Glu Val 
            580                 585                 590         


Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Val Asn 
        595                 600                 605             


Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr Tyr 
    610                 615                 620                 


Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu 
625                 630                 635                 640 


Tyr Arg Tyr Asp Lys Lys Leu Asp Lys Tyr Asn Asn Thr Gly Arg Phe 
                645                 650                 655     


Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg Gln 
            660                 665                 670         


Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val Ser 
        675                 680                 685             


Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile 
    690                 695                 700                 


Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys Glu 
705                 710                 715                 720 


Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His Lys 
                725                 730                 735     


Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile Phe 
            740                 745                 750         


Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn Tyr 
        755                 760                 765             


Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu Pro 
    770                 775                 780                 


Asn Gln Ala Ser Lys Leu Glu Phe Asp Arg Lys Ile Lys Lys Phe Asn 
785                 790                 795                 800 


Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu Arg 
                805                 810                 815     


Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala His 
            820                 825                 830         


Arg Met Gln Gln Ile Lys Val Ala Lys Pro Val Glu Gly Asn Lys Asp 
        835                 840                 845             


Asn Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro Thr 
    850                 855                 860                 


Arg Ile Val Asp Gly Ala Val Lys Lys Ile Ala Thr Ile Leu Ala Arg 
865                 870                 875                 880 


Asn Ile Val Asp Asp Asn Trp Asp Asn Ile Lys Gln Ala Leu Ser Asn 
                885                 890                 895     


Asn Gln Gln Leu His Val Pro Ile Ile Thr Glu Ser Asn Ala Phe Glu 
            900                 905                 910         


Phe Glu Pro Ala Leu Ala Asp Ile Lys Gly Lys Ser Leu Lys Asp Lys 
        915                 920                 925             


Arg Lys Lys Ala Leu Glu Arg Ile Asp Pro Glu Asn Val Phe Lys Asp 
    930                 935                 940                 


Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr Ser 
945                 950                 955                 960 


Asp Ala Asn Leu Ala Asn Gly Asp Phe Asp Gly Ala Lys Glu Glu Leu 
                965                 970                 975     


Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn Asp 
            980                 985                 990         


Glu Ala Asn Leu Ile Cys Val Thr  Arg Glu Asp Asn Gln  Asn Arg Gly 
        995                 1000                 1005             


Asn Lys  Ala Val Phe Leu Tyr  Asp Leu Lys Pro Asn  Tyr Lys Leu 
    1010                 1015                 1020             


Lys Gln  Phe Asn Thr Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile 
    1025                 1030                 1035             


Ala Asp  Thr Ile Trp Asp Ala  Ser Lys Gln Asp Phe  Lys Phe Gly 
    1040                 1045                 1050             


Asn Tyr  Arg Ser Phe Ile Asn  Leu Thr Pro Gln Glu  Gln Ile Ala 
    1055                 1060                 1065             


Phe Arg  His Ala Leu Phe Leu  Ala Asp Lys Asn Pro  Ile Lys Lys 
    1070                 1075                 1080             


Ala Val  Ile Arg Ala Ile Asp  Asn Arg Asn Arg Thr  Phe Val Asn 
    1085                 1090                 1095             


Gly Thr  Gln Arg Tyr Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr 
    1100                 1105                 1110             


Leu Arg  Ala Lys Lys Glu Asn  Leu Ala Thr Asn Arg  Ile Thr Phe 
    1115                 1120                 1125             


Asp Tyr  Phe Gly Ile Glu Thr  Thr Asn Ser Asn Gly  Arg Gly Ile 
    1130                 1135                 1140             


Ala Asp  Val Arg Lys Leu Tyr  Glu Lys Val Asp Ser  Asp Ile Gln 
    1145                 1150                 1155             


Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Asp Ser Tyr  Ser His Leu 
    1160                 1165                 1170             


Ile Asp  Ala Met Ile Ala Phe  Cys Val Ala Ala Asp  Glu His Lys 
    1175                 1180                 1185             


Asn Glu  Gly Ser Ile Gly Leu  Lys Met Gly Asn Gln  Tyr Gly Leu 
    1190                 1195                 1200             


Phe Pro  Thr Pro Asp Lys Tyr  Asp Glu Asn Thr Gly  Glu Ile Ile 
    1205                 1210                 1215             


Ser Trp  His Asn Asp Asp Ile  Phe Arg Lys Ile Lys  Val Ser Asp 
    1220                 1225                 1230             


Asn Gln  Phe Ser Asp Lys Lys  Leu Val Arg Lys Lys  Ala Thr Glu 
    1235                 1240                 1245             


Gly Phe  Asn Thr His Arg Gln  Met Thr Arg Asp Gly  Ile Tyr Gly 
    1250                 1255                 1260             


Glu Ser  Tyr Leu Pro Ile Leu  Ile His Lys Asn Leu  Asn Glu Val 
    1265                 1270                 1275             


Arg Lys  Gly Tyr Asn Trp Glu  Asn Ser Glu Glu Ile  Lys Ile Phe 
    1280                 1285                 1290             


Lys Gly  Lys Lys Tyr Asp Ile  Gln Gln Leu Asn Asn  Leu Val Tyr 
    1295                 1300                 1305             


Cys Leu  Lys Phe Val Asp Lys  Pro Ile Ser Ile Asp  Ile Gln Ile 
    1310                 1315                 1320             


Thr Thr  Leu Glu Glu Leu Arg  Asn Ile Leu Glu Thr  Asn Asn Ile 
    1325                 1330                 1335             


Ser Thr  Thr Ala Glu Tyr Tyr  Tyr Ile Asn Leu Lys  Thr Gln Lys 
    1340                 1345                 1350             


Leu His  Glu Tyr Tyr Ile Glu  Asn Tyr Asn Thr Ala  Leu Gly Tyr 
    1355                 1360                 1365             


Lys Lys  Tyr Thr Lys Glu Met  Glu Phe Leu Arg Ser  Leu Ala Tyr 
    1370                 1375                 1380             


Arg Thr  Glu Arg Val Lys Ile  Lys Ser Ile Asp Asp  Val Ser Met 
    1385                 1390                 1395             


Ile Leu  Ala Lys Asp Ser Asn  Phe Lys Ala Gly Lys  Ile Glu Leu 
    1400                 1405                 1410             


Pro Phe  Lys Thr Glu Trp Gln  Arg Leu Tyr Leu Glu  Trp Gln Asn 
    1415                 1420                 1425             


Thr Thr  Ile Lys Asp Asn His  Glu Phe Leu Lys Ser  Tyr Phe Ser 
    1430                 1435                 1440             


Val Lys  Asn Ala Thr Lys Gln  His Lys Lys Val Arg  Lys Asp Phe 
    1445                 1450                 1455             


Ser Leu  Pro Ile Ser Thr Asn  Glu Gly Lys Leu Leu  Val Lys Arg 
    1460                 1465                 1470             


Lys Thr  Trp Asp Asn Asn Phe  Ile Tyr Gln Ile Leu  Asn Asp Ser 
    1475                 1480                 1485             


Asp Ser  Arg Ala Asp Gly Thr  Lys Pro Phe Ile Pro  Ala Phe Asp 
    1490                 1495                 1500             


Ile Ser  Lys Asn Glu Ile Val  Glu Thr Ile Ile Lys  Ser Phe Thr 
    1505                 1510                 1515             


Ser Lys  Asn Ile Phe Trp Leu  Pro Lys Asn Ile Glu  Leu Gln Lys 
    1520                 1525                 1530             


Val Asp  Asn Lys Ser Ile Phe  Ala Ile Asp Thr Ser  Arg Trp Phe 
    1535                 1540                 1545             


Glu Val  Glu Thr Pro Lys Asp  Leu Ile Glu Ile Gly  Val Ser Thr 
    1550                 1555                 1560             


Ile Gln  Tyr Lys Ile Asp Asn  Asn Ser Arg Pro Lys  Val Arg Val 
    1565                 1570                 1575             


Lys Leu  Asp Tyr Val Met Asp  Asp Asp Ser Lys Ile  Asn Tyr Phe 
    1580                 1585                 1590             


Met Asn  His Ser Leu Leu Lys  Ser Arg Tyr Pro Asp  Lys Val Leu 
    1595                 1600                 1605             


Glu Ile  Leu Lys Gln Ser Thr  Ile Ile Glu Phe Glu  Ser Ser Gly 
    1610                 1615                 1620             


Phe Asn  Lys Thr Ile Lys Glu  Met Leu Gly Met Thr  Leu Ala Gly 
    1625                 1630                 1635             


Ile Tyr  Asn Glu Thr Ser Asn  Asn 
    1640                 1645     


<210> 227
<211> 1629
<212> PRT
<213> Francisella tularensis

<400> 227
Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Arg Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ile 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Ile Gln Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Glu Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Arg Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Thr Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asn  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Thr  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asp Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Leu  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Thr  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Ile Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Val  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Val Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Thr Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Thr Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210> 228
<211> 1629
<212> PRT
<213> Francisella novicida


<220>
<223> Francisella novicida FTG

<400> 228
Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Val  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Val Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Thr Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Thr Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Thr Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210> 229
<211> 1629
<212> PRT
<213> Francisella novicida


<220>
<223> Francisella novicida GA99-3548

<400> 229
Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Lys Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Arg Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Glu Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Thr Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Gly Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Leu Lys Asp Gln Asp Lys Lys Glu Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Asn Ala Gly 
            420                 425                 430         


Leu Ile Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ile Ile Gln Asp Tyr Leu Glu Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Lys Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu Asp Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Asp Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  His Asp Leu 
        995                 1000                 1005             


Ala Asn  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Ser Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Val Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Thr  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asp Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Leu  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Thr  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Val  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Val Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Thr Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Thr Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210> 230
<211> 1629
<212> PRT
<213> Francisella tularensis

<400> 230
Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210> 231
<211> 1629
<212> PRT
<213> Francisella novicida


<220>
<223> Francisella novicida GA99-3549

<400> 231
Met Asn Val Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Arg Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ile 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Glu Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Thr Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Gly Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Glu Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu Asp Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Ile Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Asp Asn Leu Ala Ser Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Asp Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  His Asp Leu 
        995                 1000                 1005             


Ala Asn  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Ser Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Val Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asn Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Thr  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asp Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Gly Asn Ser  Glu Glu Leu Lys Ile  His Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Ile Asp Lys Ser Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Thr 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Thr  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Val  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Val Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Thr Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Thr Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210> 232
<211> 1323
<212> PRT
<213> Fructobacillus fructosus


<220>
<223> Fructobacillus fructosus KCTC 3544

<400> 232
Met Val Tyr Asp Val Gly Leu Asp Ile Gly Thr Gly Ser Val Gly Trp 
1               5                   10                  15      


Val Ala Leu Asp Glu Asn Gly Lys Leu Ala Arg Ala Lys Gly Lys Asn 
            20                  25                  30          


Leu Val Gly Val Arg Leu Phe Asp Thr Ala Gln Thr Ala Ala Asp Arg 
        35                  40                  45              


Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg Lys Trp Arg 
    50                  55                  60                  


Leu Arg Leu Leu Asp Glu Leu Phe Ser Ala Glu Ile Asn Glu Ile Asp 
65                  70                  75                  80  


Ser Ser Phe Phe Gln Arg Leu Lys Tyr Ser Tyr Val His Pro Lys Asp 
                85                  90                  95      


Glu Glu Asn Lys Ala His Tyr Tyr Gly Gly Tyr Leu Phe Pro Thr Glu 
            100                 105                 110         


Glu Glu Thr Lys Lys Phe His Arg Ser Tyr Pro Thr Ile Tyr His Leu 
        115                 120                 125             


Arg Gln Glu Leu Met Ala Gln Pro Asn Lys Arg Phe Asp Ile Arg Glu 
    130                 135                 140                 


Ile Tyr Leu Ala Ile His His Leu Val Lys Tyr Arg Gly His Phe Leu 
145                 150                 155                 160 


Ser Ser Gln Glu Lys Ile Thr Ile Gly Ser Thr Tyr Asn Pro Glu Asp 
                165                 170                 175     


Leu Ala Asn Ala Ile Glu Val Tyr Ala Asp Glu Lys Gly Leu Ser Trp 
            180                 185                 190         


Glu Leu Asn Asn Pro Glu Gln Leu Thr Glu Ile Ile Ser Gly Glu Ala 
        195                 200                 205             


Gly Tyr Gly Leu Asn Lys Ser Met Lys Ala Asp Glu Ala Leu Lys Leu 
    210                 215                 220                 


Phe Glu Phe Asp Asn Asn Gln Asp Lys Val Ala Ile Lys Thr Leu Leu 
225                 230                 235                 240 


Ala Gly Leu Thr Gly Asn Gln Ile Asp Phe Ala Lys Leu Phe Gly Lys 
                245                 250                 255     


Asp Ile Ser Asp Lys Asp Glu Ala Lys Leu Trp Lys Leu Lys Leu Asp 
            260                 265                 270         


Asp Glu Ala Leu Glu Glu Lys Ser Gln Thr Ile Leu Ser Gln Leu Thr 
        275                 280                 285             


Asp Glu Glu Ile Glu Leu Phe His Ala Val Val Gln Ala Tyr Asp Gly 
    290                 295                 300                 


Phe Val Leu Ile Gly Leu Leu Asn Gly Ala Asp Ser Val Ser Ala Ala 
305                 310                 315                 320 


Met Val Gln Leu Tyr Asp Gln His Arg Glu Asp Arg Lys Leu Leu Lys 
                325                 330                 335     


Ser Leu Ala Gln Lys Ala Gly Leu Lys His Lys Arg Phe Ser Glu Ile 
            340                 345                 350         


Tyr Glu Gln Leu Ala Leu Ala Thr Asp Glu Ala Thr Ile Lys Asn Gly 
        355                 360                 365             


Ile Ser Thr Ala Arg Glu Leu Val Glu Glu Ser Asn Leu Ser Lys Glu 
    370                 375                 380                 


Val Lys Glu Asp Thr Leu Arg Arg Leu Asp Glu Asn Glu Phe Leu Pro 
385                 390                 395                 400 


Lys Gln Arg Thr Lys Ala Asn Ser Val Ile Pro His Gln Leu His Leu 
                405                 410                 415     


Ala Glu Leu Gln Lys Ile Leu Gln Asn Gln Gly Gln Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Leu Asp Thr Phe Glu Lys Glu Asp Gly Gln Asp Asn Lys Ile Glu 
        435                 440                 445             


Glu Leu Leu Arg Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr 
    450                 455                 460                 


Lys Lys Asp Val Glu His Ala Gly Gly Asp Ala Asp Asn His Trp Val 
465                 470                 475                 480 


Glu Arg Asn Glu Gly Phe Glu Lys Ser Arg Val Thr Pro Trp Asn Phe 
                485                 490                 495     


Asp Lys Val Phe Asn Arg Asp Lys Ala Ala Arg Asp Phe Ile Glu Arg 
            500                 505                 510         


Leu Thr Gly Asn Asp Thr Tyr Leu Ile Gly Glu Lys Thr Leu Pro Gln 
        515                 520                 525             


Asn Ser Leu Arg Tyr Gln Leu Phe Thr Val Leu Asn Glu Leu Asn Asn 
    530                 535                 540                 


Val Arg Val Asn Gly Lys Lys Phe Asp Ser Lys Thr Lys Ala Asp Leu 
545                 550                 555                 560 


Ile Asn Asp Leu Phe Lys Ala Arg Lys Thr Val Ser Leu Ser Ala Leu 
                565                 570                 575     


Lys Asp Tyr Leu Lys Ala Gln Gly Lys Gly Asp Val Thr Ile Thr Gly 
            580                 585                 590         


Leu Ala Asp Glu Ser Lys Phe Asn Ser Ser Leu Ser Ser Tyr Asn Asp 
        595                 600                 605             


Leu Lys Lys Thr Phe Asp Ala Glu Tyr Leu Glu Asn Glu Asp Asn Gln 
    610                 615                 620                 


Glu Thr Leu Glu Lys Ile Ile Glu Ile Gln Thr Val Phe Glu Asp Ser 
625                 630                 635                 640 


Lys Ile Ala Ser Arg Glu Leu Ser Lys Leu Pro Leu Asp Asp Asp Gln 
                645                 650                 655     


Val Lys Lys Leu Ser Gln Thr His Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Glu Lys Leu Leu Asp Ser Lys Ile Ile Asp Glu Arg Gly Gln Lys Val 
        675                 680                 685             


Ser Ile Leu Asp Lys Leu Lys Ser Thr Ser Gln Asn Phe Met Ser Ile 
    690                 695                 700                 


Ile Asn Asn Asp Lys Tyr Gly Val Gln Ala Trp Ile Thr Glu Gln Asn 
705                 710                 715                 720 


Thr Gly Ser Ser Lys Leu Thr Phe Asp Glu Lys Val Asn Glu Leu Thr 
                725                 730                 735     


Thr Ser Pro Ala Asn Lys Arg Gly Ile Lys Gln Ser Phe Ala Val Leu 
            740                 745                 750         


Asn Asp Ile Lys Lys Ala Met Lys Glu Glu Pro Arg Arg Val Tyr Leu 
        755                 760                 765             


Glu Phe Ala Arg Glu Asp Gln Thr Ser Val Arg Ser Val Pro Arg Tyr 
    770                 775                 780                 


Asn Gln Leu Lys Glu Lys Tyr Gln Ser Lys Ser Leu Ser Glu Glu Ala 
785                 790                 795                 800 


Lys Val Leu Lys Lys Thr Leu Asp Gly Asn Lys Asn Lys Met Ser Asp 
                805                 810                 815     


Asp Arg Tyr Phe Leu Tyr Phe Gln Gln Gln Gly Lys Asp Met Tyr Thr 
            820                 825                 830         


Gly Arg Pro Ile Asn Phe Glu Arg Leu Ser Gln Asp Tyr Asp Ile Asp 
        835                 840                 845             


His Ile Ile Pro Gln Ala Phe Thr Lys Asp Asp Ser Leu Asp Asn Arg 
    850                 855                 860                 


Val Leu Val Ser Arg Pro Glu Asn Ala Arg Lys Ser Asp Ser Phe Ala 
865                 870                 875                 880 


Tyr Thr Asp Glu Val Gln Lys Gln Asp Gly Ser Leu Trp Thr Ser Leu 
                885                 890                 895     


Leu Lys Ser Gly Phe Ile Asn Arg Lys Lys Tyr Glu Arg Leu Thr Lys 
            900                 905                 910         


Ala Gly Lys Tyr Leu Asp Gly Gln Lys Thr Gly Phe Ile Ala Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Ile Lys Asn Val Ala Ser Leu Ile Glu 
    930                 935                 940                 


Gly Glu Tyr Glu Asn Ser Lys Ala Val Ala Ile Arg Ser Glu Ile Thr 
945                 950                 955                 960 


Ala Asp Met Arg Leu Leu Val Gly Ile Lys Lys His Arg Glu Ile Asn 
                965                 970                 975     


Ser Phe His His Ala Phe Asp Ala Leu Leu Ile Thr Ala Ala Gly Gln 
            980                 985                 990         


Tyr Met Gln Asn Arg Tyr Pro Asp  Arg Asp Ser Thr Asn  Val Tyr Asn 
        995                 1000                 1005             


Glu Phe  Asp Arg Tyr Thr Asn  Asp Tyr Leu Lys Asn  Leu Arg Gln 
    1010                 1015                 1020             


Leu Ser  Ser Arg Asp Glu Val  Arg Arg Leu Lys Ser  Phe Gly Phe 
    1025                 1030                 1035             


Val Val  Gly Thr Met Arg Lys  Gly Asn Glu Asp Trp  Ser Glu Glu 
    1040                 1045                 1050             


Asn Thr  Ser Tyr Leu Arg Lys  Val Met Met Phe Lys  Asn Ile Leu 
    1055                 1060                 1065             


Thr Thr  Lys Lys Thr Glu Lys  Asp Arg Gly Pro Leu  Asn Lys Glu 
    1070                 1075                 1080             


Thr Ile  Phe Ser Pro Lys Ser  Gly Lys Lys Leu Ile  Pro Leu Asn 
    1085                 1090                 1095             


Ser Lys  Arg Ser Asp Thr Ala  Leu Tyr Gly Gly Tyr  Ser Asn Val 
    1100                 1105                 1110             


Tyr Ser  Ala Tyr Met Thr Leu  Val Arg Ala Asn Gly  Lys Asn Leu 
    1115                 1120                 1125             


Leu Ile  Lys Ile Pro Ile Ser  Ile Ala Asn Gln Ile  Glu Val Gly 
    1130                 1135                 1140             


Asn Leu  Lys Ile Asn Asp Tyr  Ile Val Asn Asn Pro  Ala Ile Lys 
    1145                 1150                 1155             


Lys Phe  Glu Lys Ile Leu Ile  Ser Lys Leu Pro Leu  Gly Gln Leu 
    1160                 1165                 1170             


Val Asn  Glu Asp Gly Asn Leu  Ile Tyr Leu Ala Ser  Asn Glu Tyr 
    1175                 1180                 1185             


Arg His  Asn Ala Lys Gln Leu  Trp Leu Ser Thr Thr  Asp Ala Asp 
    1190                 1195                 1200             


Lys Ile  Ala Ser Ile Ser Glu  Asn Ser Ser Asp Glu  Glu Leu Leu 
    1205                 1210                 1215             


Glu Ala  Tyr Asp Ile Leu Thr  Ser Glu Asn Val Lys  Asn Arg Phe 
    1220                 1225                 1230             


Pro Phe  Phe Lys Lys Asp Ile  Asp Lys Leu Ser Gln  Val Arg Asp 
    1235                 1240                 1245             


Glu Phe  Leu Asp Ser Asp Lys  Arg Ile Ala Val Ile  Gln Thr Ile 
    1250                 1255                 1260             


Leu Arg  Gly Leu Gln Ile Asp  Ala Ala Tyr Gln Ala  Pro Val Lys 
    1265                 1270                 1275             


Ile Ile  Ser Lys Lys Val Ser  Asp Trp His Lys Leu  Gln Gln Ser 
    1280                 1285                 1290             


Gly Gly  Ile Lys Leu Ser Asp  Asn Ser Glu Met Ile  Tyr Gln Ser 
    1295                 1300                 1305             


Ala Thr  Gly Ile Phe Glu Thr  Arg Val Lys Ile Ser  Asp Leu Leu 
    1310                 1315                 1320             


<210> 233
<211> 1374
<212> PRT
<213> Fusobacterium nucleatum


<220>
<223> Fusobacterium nucleatum subsp. vincentii ATCC 49256

<400> 233
Met Lys Lys Gln Lys Phe Ser Asp Tyr Tyr Leu Gly Phe Asp Ile Gly 
1               5                   10                  15      


Thr Asn Ser Val Gly Trp Cys Val Thr Asp Leu Asp Tyr Asn Val Leu 
            20                  25                  30          


Arg Phe Asn Lys Lys Asp Met Trp Gly Ser Arg Leu Phe Asp Glu Ala 
        35                  40                  45              


Lys Thr Ala Ala Glu Arg Arg Val Gln Arg Asn Ser Arg Arg Arg Leu 
    50                  55                  60                  


Lys Arg Arg Lys Trp Arg Leu Asn Leu Leu Glu Glu Ile Phe Ser Asp 
65                  70                  75                  80  


Glu Ile Met Lys Ile Asp Ser Asn Phe Phe Arg Arg Leu Lys Glu Ser 
                85                  90                  95      


Ser Leu Trp Leu Glu Asp Lys Asn Ser Lys Glu Lys Phe Thr Leu Phe 
            100                 105                 110         


Asn Asp Asp Asn Tyr Lys Asp Tyr Asp Phe Tyr Lys Gln Tyr Pro Thr 
        115                 120                 125             


Ile Phe His Leu Arg Asp Glu Leu Ile Lys Asn Pro Glu Lys Lys Asp 
    130                 135                 140                 


Ile Arg Leu Ile Tyr Leu Ala Leu His Ser Ile Phe Lys Ser Arg Gly 
145                 150                 155                 160 


His Phe Leu Phe Glu Gly Gln Asn Leu Lys Glu Ile Lys Asn Phe Glu 
                165                 170                 175     


Thr Leu Tyr Asn Asn Leu Ile Ser Phe Leu Glu Asp Asn Gly Ile Asn 
            180                 185                 190         


Lys Ser Ile Asp Lys Asp Asn Ile Glu Lys Leu Glu Lys Ile Ile Cys 
        195                 200                 205             


Asp Ser Gly Lys Gly Leu Lys Asp Lys Glu Lys Glu Phe Lys Gly Ile 
    210                 215                 220                 


Phe Asn Ser Asp Lys Gln Leu Val Ala Ile Phe Lys Leu Ser Val Gly 
225                 230                 235                 240 


Ser Ser Val Ser Leu Asn Asp Leu Phe Asp Thr Asp Glu Tyr Lys Lys 
                245                 250                 255     


Glu Glu Val Glu Lys Glu Lys Ile Ser Phe Arg Glu Gln Ile Tyr Glu 
            260                 265                 270         


Asp Asp Lys Pro Ile Tyr Tyr Ser Ile Leu Gly Glu Lys Ile Glu Leu 
        275                 280                 285             


Leu Asp Ile Ala Lys Ser Phe Tyr Asp Phe Met Val Leu Asn Asn Ile 
    290                 295                 300                 


Leu Ser Asp Ser Asn Tyr Ile Ser Glu Ala Lys Val Lys Leu Tyr Glu 
305                 310                 315                 320 


Glu His Lys Lys Asp Leu Lys Asn Leu Lys Tyr Ile Ile Arg Lys Tyr 
                325                 330                 335     


Asn Lys Glu Asn Tyr Asp Lys Leu Phe Lys Asp Lys Asn Glu Asn Asn 
            340                 345                 350         


Tyr Pro Ala Tyr Ile Gly Leu Asn Lys Glu Lys Asp Lys Lys Glu Val 
        355                 360                 365             


Val Glu Lys Ser Arg Leu Lys Ile Asp Asp Leu Ile Lys Val Ile Lys 
    370                 375                 380                 


Gly Tyr Leu Pro Lys Pro Glu Arg Ile Glu Glu Lys Asp Lys Thr Ile 
385                 390                 395                 400 


Phe Asn Glu Ile Leu Asn Lys Ile Glu Leu Lys Thr Ile Leu Pro Lys 
                405                 410                 415     


Gln Arg Ile Ser Asp Asn Gly Thr Leu Pro Tyr Gln Ile His Glu Val 
            420                 425                 430         


Glu Leu Glu Lys Ile Leu Glu Asn Gln Ser Lys Tyr Tyr Asp Phe Leu 
        435                 440                 445             


Asn Tyr Glu Glu Asn Gly Val Ser Thr Lys Asp Lys Leu Leu Lys Thr 
    450                 455                 460                 


Phe Lys Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Ser Tyr His 
465                 470                 475                 480 


Lys Asp Lys Gly Gly Asn Ser Trp Ile Val Arg Lys Glu Glu Gly Lys 
                485                 490                 495     


Ile Leu Pro Trp Asn Phe Glu Gln Lys Val Asp Ile Glu Lys Ser Ala 
            500                 505                 510         


Glu Glu Phe Ile Lys Arg Met Thr Asn Lys Cys Thr Tyr Leu Asn Gly 
        515                 520                 525             


Glu Asp Val Ile Pro Lys Asp Ser Phe Leu Tyr Ser Glu Tyr Ile Ile 
    530                 535                 540                 


Leu Asn Glu Leu Asn Lys Val Gln Val Asn Asp Glu Phe Leu Asn Glu 
545                 550                 555                 560 


Glu Asn Lys Arg Lys Ile Ile Asp Glu Leu Phe Lys Glu Asn Lys Lys 
                565                 570                 575     


Val Ser Glu Lys Lys Phe Lys Glu Tyr Leu Leu Val Asn Gln Ile Ala 
            580                 585                 590         


Asn Arg Thr Val Glu Leu Lys Gly Ile Lys Asp Ser Phe Asn Ser Asn 
        595                 600                 605             


Tyr Val Ser Tyr Ile Lys Phe Lys Asp Ile Phe Gly Glu Lys Leu Asn 
    610                 615                 620                 


Leu Asp Ile Tyr Lys Glu Ile Ser Glu Lys Ser Ile Leu Trp Lys Cys 
625                 630                 635                 640 


Leu Tyr Gly Asp Asp Lys Lys Ile Phe Glu Lys Lys Ile Lys Asn Glu 
                645                 650                 655     


Tyr Gly Asp Ile Leu Asn Lys Asp Glu Ile Lys Lys Ile Asn Ser Phe 
            660                 665                 670         


Lys Phe Asn Thr Trp Gly Arg Leu Ser Glu Lys Leu Leu Thr Gly Ile 
        675                 680                 685             


Glu Phe Ile Asn Leu Glu Thr Gly Glu Cys Tyr Ser Ser Val Met Glu 
    690                 695                 700                 


Ala Leu Arg Arg Thr Asn Tyr Asn Leu Met Glu Leu Leu Ser Ser Lys 
705                 710                 715                 720 


Phe Thr Leu Gln Glu Ser Ile Asp Asn Glu Asn Lys Glu Met Asn Glu 
                725                 730                 735     


Val Ser Tyr Arg Asp Leu Ile Glu Glu Ser Tyr Val Ser Pro Ser Leu 
            740                 745                 750         


Lys Arg Ala Ile Leu Gln Thr Leu Lys Ile Tyr Glu Glu Ile Lys Lys 
        755                 760                 765             


Ile Thr Gly Arg Val Pro Lys Lys Val Phe Ile Glu Met Ala Arg Gly 
    770                 775                 780                 


Gly Asp Glu Ser Met Lys Asn Lys Lys Ile Pro Ala Arg Gln Glu Gln 
785                 790                 795                 800 


Leu Lys Lys Leu Tyr Asp Ser Cys Gly Asn Asp Ile Ala Asn Phe Ser 
                805                 810                 815     


Ile Asp Ile Lys Glu Met Lys Asn Ser Leu Ser Ser Tyr Asp Asn Asn 
            820                 825                 830         


Ser Leu Arg Gln Lys Lys Leu Tyr Leu Tyr Tyr Leu Gln Phe Gly Lys 
        835                 840                 845             


Cys Met Tyr Thr Gly Arg Glu Ile Asp Leu Asp Arg Leu Leu Gln Asn 
    850                 855                 860                 


Asn Asp Thr Tyr Asp Ile Asp His Ile Tyr Pro Arg Ser Lys Val Ile 
865                 870                 875                 880 


Lys Asp Asp Ser Phe Asp Asn Leu Val Leu Val Leu Lys Asn Glu Asn 
                885                 890                 895     


Ala Glu Lys Ser Asn Glu Tyr Pro Val Lys Lys Glu Ile Gln Glu Lys 
            900                 905                 910         


Met Lys Ser Phe Trp Arg Phe Leu Lys Glu Lys Asn Phe Ile Ser Asp 
        915                 920                 925             


Glu Lys Tyr Lys Arg Leu Thr Gly Lys Asp Asp Phe Glu Leu Arg Gly 
    930                 935                 940                 


Phe Met Ala Arg Gln Leu Val Asn Val Arg Gln Thr Thr Lys Glu Val 
945                 950                 955                 960 


Gly Lys Ile Leu Gln Gln Ile Glu Pro Glu Ile Lys Ile Val Tyr Ser 
                965                 970                 975     


Lys Ala Glu Ile Ala Ser Ser Phe Arg Glu Met Phe Asp Phe Ile Lys 
            980                 985                 990         


Val Arg Glu Leu Asn Asp Thr His  His Ala Lys Asp Ala  Tyr Leu Asn 
        995                 1000                 1005             


Ile Val  Ala Gly Asn Val Tyr  Asn Thr Lys Phe Thr  Glu Lys Pro 
    1010                 1015                 1020             


Tyr Arg  Tyr Leu Gln Glu Ile  Lys Glu Asn Tyr Asp  Val Lys Lys 
    1025                 1030                 1035             


Ile Tyr  Asn Tyr Asp Ile Lys  Asn Ala Trp Asp Lys  Glu Asn Ser 
    1040                 1045                 1050             


Leu Glu  Ile Val Lys Lys Asn  Met Glu Lys Asn Thr  Val Asn Ile 
    1055                 1060                 1065             


Thr Arg  Phe Ile Lys Glu Glu  Lys Gly Glu Leu Phe  Asn Leu Asn 
    1070                 1075                 1080             


Pro Ile  Lys Lys Gly Glu Thr  Ser Asn Glu Ile Ile  Ser Ile Lys 
    1085                 1090                 1095             


Pro Lys  Leu Tyr Asp Gly Lys  Asp Asn Lys Leu Asn  Glu Lys Tyr 
    1100                 1105                 1110             


Gly Tyr  Tyr Thr Ser Leu Lys  Ala Ala Tyr Phe Ile  Tyr Val Glu 
    1115                 1120                 1125             


His Glu  Lys Lys Asn Lys Lys  Val Lys Thr Phe Glu  Arg Ile Thr 
    1130                 1135                 1140             


Arg Ile  Asp Ser Thr Leu Ile  Lys Asn Glu Lys Asn  Leu Ile Lys 
    1145                 1150                 1155             


Tyr Leu  Val Ser Gln Lys Lys  Leu Leu Asn Pro Lys  Ile Ile Lys 
    1160                 1165                 1170             


Lys Ile  Tyr Lys Glu Gln Thr  Leu Ile Ile Asp Ser  Tyr Pro Tyr 
    1175                 1180                 1185             


Thr Phe  Thr Gly Val Asp Ser  Asn Lys Lys Val Glu  Leu Lys Asn 
    1190                 1195                 1200             


Lys Lys  Gln Leu Tyr Leu Glu  Lys Lys Tyr Glu Gln  Ile Leu Lys 
    1205                 1210                 1215             


Asn Ala  Leu Lys Phe Val Glu  Asp Asn Gln Gly Glu  Thr Glu Glu 
    1220                 1225                 1230             


Asn Tyr  Lys Phe Ile Tyr Leu  Lys Lys Arg Asn Asn  Asn Glu Lys 
    1235                 1240                 1245             


Asn Glu  Thr Ile Asp Ala Val  Lys Glu Arg Tyr Asn  Ile Glu Phe 
    1250                 1255                 1260             


Asn Glu  Met Tyr Asp Lys Phe  Leu Glu Lys Leu Ser  Ser Lys Asp 
    1265                 1270                 1275             


Tyr Lys  Asn Tyr Ile Asn Asn  Lys Leu Tyr Thr Asn  Phe Leu Asn 
    1280                 1285                 1290             


Ser Lys  Glu Lys Phe Lys Lys  Leu Lys Leu Trp Glu  Lys Ser Leu 
    1295                 1300                 1305             


Ile Leu  Arg Glu Phe Leu Lys  Ile Phe Asn Lys Asn  Thr Tyr Gly 
    1310                 1315                 1320             


Lys Tyr  Glu Ile Lys Asp Ser  Gln Thr Lys Glu Lys  Leu Phe Ser 
    1325                 1330                 1335             


Phe Pro  Glu Asp Thr Gly Arg  Ile Arg Leu Gly Gln  Ser Ser Leu 
    1340                 1345                 1350             


Gly Asn  Asn Lys Glu Leu Leu  Glu Glu Ser Val Thr  Gly Leu Phe 
    1355                 1360                 1365             


Val Lys  Lys Ile Lys Leu 
    1370                 


<210> 234
<211> 1367
<212> PRT
<213> Fusobacterium sp.


<220>
<223> Fusobacterium sp. 1_1_41FAA

<400> 234
Met Lys Lys Gln Gln Phe Ser Asp Tyr Tyr Leu Gly Phe Asp Ile Gly 
1               5                   10                  15      


Thr Asn Ser Val Gly Trp Cys Val Thr Asp Phe Asn Tyr Asn Val Leu 
            20                  25                  30          


Arg Phe Asn Lys Lys Asp Met Trp Gly Ser Arg Leu Phe Asp Glu Ala 
        35                  40                  45              


Lys Thr Ala Ala Glu Arg Arg Val Gln Arg Asn Ser Arg Arg Arg Leu 
    50                  55                  60                  


Lys Arg Arg Lys Trp Arg Leu Asn Leu Leu Glu Glu Ile Phe Ser Asp 
65                  70                  75                  80  


Glu Ile Leu Lys Ile Asp Ser Asn Phe Phe Arg Arg Leu Lys Glu Ser 
                85                  90                  95      


Ser Leu Trp Leu Glu Asp Lys Ser Ser Lys Glu Lys Phe Thr Leu Phe 
            100                 105                 110         


Asn Asp Asp Asn Tyr Lys Asp Tyr Asp Phe Tyr Lys Gln Tyr Pro Thr 
        115                 120                 125             


Ile Phe His Leu Arg Asn Glu Leu Ile Lys Asn Pro Glu Lys Lys Asp 
    130                 135                 140                 


Ile Arg Leu Val Tyr Leu Ala Leu His Ser Ile Phe Lys Ser Arg Gly 
145                 150                 155                 160 


His Phe Leu Phe Glu Gly Gln Asn Leu Lys Asp Ile Lys Asn Phe Glu 
                165                 170                 175     


Thr Leu Tyr Asn Asn Leu Met Ala Phe Leu Glu Asp Asn Asp Ile Tyr 
            180                 185                 190         


Lys Asn Ile Asp Ser Ser Tyr Ile Gly Asn Leu Glu Asn Ile Ile Cys 
        195                 200                 205             


Asp Ser Lys Lys Gly Leu Lys Asp Lys Glu Lys Glu Phe Lys Glu Ile 
    210                 215                 220                 


Phe Asn Ser Asp Lys Gln Leu Val Gly Phe Phe Lys Leu Ser Val Gly 
225                 230                 235                 240 


Ser Ser Val Ser Leu Asn Asp Leu Phe Asp Thr Asp Glu Tyr Lys Lys 
                245                 250                 255     


Gly Glu Val Glu Lys Glu Lys Ile Ser Phe Arg Glu Gln Ile Tyr Glu 
            260                 265                 270         


Asp Asp Lys Pro Ile Tyr Tyr Ser Ile Leu Gly Glu Lys Ile Glu Phe 
        275                 280                 285             


Leu Asp Ile Ala Lys Ser Phe Tyr Asp Phe Met Val Leu Asn Asn Ile 
    290                 295                 300                 


Leu Ala Asp Ser Gln Tyr Ile Ser Glu Ala Lys Val Lys Leu Tyr Asp 
305                 310                 315                 320 


Glu His Lys Arg Asp Leu Lys Asn Leu Lys Tyr Ile Ile Arg Lys Tyr 
                325                 330                 335     


Asn Lys Glu Asn Tyr Asp Lys Leu Phe Lys Asp Lys Asn Glu Ser Asn 
            340                 345                 350         


Tyr Ser Ala Tyr Ile Gly Leu Asn Lys Glu Lys Gly Lys Lys Glu Val 
        355                 360                 365             


Ile Glu Lys Ser Arg Leu Lys Ile Asp Asp Phe Ala Lys Ile Ile Lys 
    370                 375                 380                 


Gly Tyr Leu Pro Lys Ala Glu Lys Ile Asp Glu Lys Asp Arg Ser Ile 
385                 390                 395                 400 


Phe Asn Glu Ile Leu Asp Lys Ile Glu Leu Lys Thr Ile Leu Pro Lys 
                405                 410                 415     


Gln Arg Ile Ser Asp Asn Gly Thr Leu Pro Tyr Gln Ile His Glu Ala 
            420                 425                 430         


Glu Leu Glu Lys Ile Leu Glu Asn Gln Ala Lys Tyr Tyr Asp Phe Leu 
        435                 440                 445             


Asn His Glu Glu Asn Gly Ile Ser Thr Lys Asp Lys Leu Leu Met Thr 
    450                 455                 460                 


Phe Lys Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Ser Tyr His 
465                 470                 475                 480 


Lys Asn Lys Gly Gly Asn Ser Trp Ile Val Arg Lys Glu Glu Gly Lys 
                485                 490                 495     


Ile Leu Pro Trp Asn Phe Glu Gln Lys Val Asp Ile Glu Lys Ser Ala 
            500                 505                 510         


Glu Glu Phe Ile Lys Arg Met Thr Asn Lys Cys Thr Tyr Leu Asn Gly 
        515                 520                 525             


Glu Asp Val Ile Pro Lys Asp Ser Phe Leu Tyr Ser Glu Tyr Ile Ile 
    530                 535                 540                 


Leu Asn Glu Leu Asn Lys Val Gln Val Asn Asp Glu Phe Leu Asn Lys 
545                 550                 555                 560 


Glu Ile Lys Lys Lys Ile Ile Glu Asp Leu Phe Lys Lys Ser Lys Lys 
                565                 570                 575     


Ile Ser Glu Lys Asn Phe Arg Glu Tyr Leu Leu Val Asn Gln Ile Thr 
            580                 585                 590         


Asn Lys Thr Val Glu Leu Lys Gly Val Lys Asp Ala Phe Asn Ser Asn 
        595                 600                 605             


Tyr Val Ser Tyr Ile Lys Phe Lys Asp Ile Phe Gly Asp Lys Leu Asn 
    610                 615                 620                 


Leu Asp Ile Tyr Lys Glu Ile Ser Glu Lys Ser Ile Leu Trp Lys Cys 
625                 630                 635                 640 


Leu Tyr Gly Asp Asp Lys Lys Ile Phe Glu Lys Lys Ile Lys Ser Val 
                645                 650                 655     


Tyr Gly Asp Ile Leu Thr Lys Asp Glu Ile Lys Lys Ile Asn Ser Phe 
            660                 665                 670         


Lys Phe Asn Thr Trp Gly Arg Leu Ser Glu Lys Leu Leu Thr Glu Ile 
        675                 680                 685             


Glu Phe Ile Asp Leu Glu Thr Gly Glu Cys Tyr Ser Ser Val Met Asp 
    690                 695                 700                 


Ala Leu Arg Arg Thr Asn Tyr Asn Leu Met Glu Leu Leu Ser Ser Lys 
705                 710                 715                 720 


Phe Thr Leu Gln Glu Asn Ile Asp Asn Glu Asn Lys Glu Val Ser Glu 
                725                 730                 735     


Phe Ser Tyr Arg Asp Leu Val Glu Glu Ser Tyr Val Ser Pro Ser Leu 
            740                 745                 750         


Lys Arg Ala Ile Leu Gln Thr Leu Lys Ile Tyr Glu Glu Ile Arg Lys 
        755                 760                 765             


Ile Thr Gly Arg Ile Pro Lys Lys Val Phe Ile Glu Met Ala Arg Gly 
    770                 775                 780                 


Gly Asp Glu Thr Met Lys Asn Lys Lys Ile Pro Ala Arg Gln Glu Gln 
785                 790                 795                 800 


Leu Lys Lys Leu Tyr Asp Ser Cys Gly Lys Asp Ile Ser Asn Phe Ser 
                805                 810                 815     


Ile Asp Ile Lys Glu Met Lys Asn Ser Leu Asn Ser Tyr Asp Asn Asn 
            820                 825                 830         


Ser Leu Arg Gln Lys Lys Leu Tyr Leu Tyr Tyr Leu Gln Phe Gly Lys 
        835                 840                 845             


Cys Met Tyr Thr Gly Lys Glu Ile Asp Leu Asn Arg Leu Leu Gln Asn 
    850                 855                 860                 


Asn Asp Thr Tyr Asp Ile Asp His Ile Tyr Pro Arg Ser Lys Val Ile 
865                 870                 875                 880 


Lys Asp Asp Ser Phe Asp Asn Leu Val Leu Val Leu Lys Asn Glu Asn 
                885                 890                 895     


Ala Glu Lys Ser Asn Glu Tyr Pro Leu Lys Lys Glu Ile Gln Glu Lys 
            900                 905                 910         


Met Lys Ser Phe Trp Lys Phe Leu Lys Glu Lys Asn Phe Ile Ser Asp 
        915                 920                 925             


Glu Lys Tyr Lys Arg Leu Thr Gly Lys Asp Glu Phe Glu Leu Arg Gly 
    930                 935                 940                 


Phe Met Ala Arg Gln Leu Val Asn Val Arg Gln Thr Thr Lys Glu Ala 
945                 950                 955                 960 


Gly Lys Ile Leu Gln Gln Ile Glu Pro Glu Ile Lys Ile Val Tyr Ser 
                965                 970                 975     


Lys Ala Glu Ile Ala Ser Ser Phe Arg Glu Met Phe Asp Phe Ile Lys 
            980                 985                 990         


Val Arg Glu Leu Asn Asp Thr His  His Ala Lys Asp Ala  Tyr Leu Asn 
        995                 1000                 1005             


Ile Val  Ala Gly Asn Val Tyr  Asn Thr Lys Phe Thr  Glu Lys Pro 
    1010                 1015                 1020             


Tyr Arg  Tyr Leu Gln Glu Ile  Lys Glu Asn Tyr Asp  Val Lys Lys 
    1025                 1030                 1035             


Ile Tyr  Asn Tyr Asp Ile Lys  Asn Ala Trp Asp Lys  Glu Lys Ser 
    1040                 1045                 1050             


Leu Glu  Ile Val Lys Lys Asn  Met Glu Lys Asn Thr  Val Asn Ile 
    1055                 1060                 1065             


Thr Arg  Phe Ile Lys Glu Glu  Lys Gly Gln Leu Phe  Asp Leu Asn 
    1070                 1075                 1080             


Pro Ile  Arg Lys Gly Glu Thr  Ser Asn Glu Ile Ile  Ala Ile Lys 
    1085                 1090                 1095             


Pro Lys  Phe Tyr Glu Gly Ser  Thr Glu Lys Leu Asn  Glu Lys Tyr 
    1100                 1105                 1110             


Gly Tyr  Tyr Lys Ser Leu Asn  Pro Ala Tyr Phe Ile  Tyr Val Glu 
    1115                 1120                 1125             


His Lys  Glu Lys Asn Lys Ile  Ile Arg Ser Phe Glu  Arg Val Asn 
    1130                 1135                 1140             


Leu Val  Asp Val Asn Lys Ile  Lys Asp Glu Lys Ser  Leu Ile Lys 
    1145                 1150                 1155             


Tyr Leu  Ile Glu Asn Lys Gly  Leu Ile Glu Pro Lys  Val Ile Lys 
    1160                 1165                 1170             


Lys Val  Tyr Lys Arg Gln Val  Ile Leu Ile Asn Asn  Phe Pro Tyr 
    1175                 1180                 1185             


Ser Ile  Val Ala Leu Asp Ser  Asn Lys Leu Met Asp  Phe Glu Asn 
    1190                 1195                 1200             


Leu Lys  Pro Leu Phe Leu Glu  Arg Lys Tyr Glu Lys  Ile Leu Lys 
    1205                 1210                 1215             


Asn Ala  Ile Lys Phe Leu Glu  Asp Asn Gln Gly Lys  Thr Glu Glu 
    1220                 1225                 1230             


Tyr Tyr  Lys Phe Leu Tyr Leu  Lys Lys Lys Asp Arg  Asn Glu Lys 
    1235                 1240                 1245             


Asn Glu  Thr Ile Asp Ser Val  Lys Glu Arg Tyr Asn  Ile Glu Phe 
    1250                 1255                 1260             


Asn Glu  Met Tyr Asp Lys Phe  Leu Glu Lys Leu Asp  Ser Lys Asp 
    1265                 1270                 1275             


Tyr Lys  Asn Tyr Ile Asn Asn  Lys Lys Tyr Ser Glu  Leu Val Asn 
    1280                 1285                 1290             


Val Lys  Glu Lys Phe Ile Lys  Leu Asn Leu Phe Asp  Lys Ala Phe 
    1295                 1300                 1305             


Thr Leu  Lys Ser Phe Leu Asp  Leu Phe Asn Arg Lys  Thr Met Ala 
    1310                 1315                 1320             


Asp Phe  Ser Lys Val Gly Leu  Thr Lys Tyr Leu Gly  Lys Ile Gln 
    1325                 1330                 1335             


Lys Ile  Ser Ser Asn Val Leu  Ser Lys Asn Glu Leu  His Leu Leu 
    1340                 1345                 1350             


Glu Glu  Ser Val Thr Gly Leu  Phe Val Lys Lys Ile  Lys Leu 
    1355                 1360                 1365         


<210> 235
<211> 1367
<212> PRT
<213> Fusobacterium sp.


<220>
<223> Fusobacterium sp. 3_1_27

<400> 235
Met Lys Lys Gln Lys Phe Ser Asp Tyr Tyr Leu Gly Phe Asp Ile Gly 
1               5                   10                  15      


Thr Asn Ser Val Gly Trp Cys Val Thr Asp Leu Asp Tyr Asn Val Leu 
            20                  25                  30          


Arg Phe Asn Lys Lys Asp Met Trp Gly Ser Arg Leu Phe Asp Glu Ala 
        35                  40                  45              


Lys Thr Ala Ala Glu Arg Arg Val Gln Arg Asn Ser Arg Arg Arg Leu 
    50                  55                  60                  


Lys Arg Arg Lys Trp Arg Leu Asn Leu Leu Glu Glu Ile Phe Ser Asp 
65                  70                  75                  80  


Glu Ile Met Lys Ile Asp Ser Asn Phe Phe Arg Arg Leu Lys Glu Ser 
                85                  90                  95      


Ser Leu Trp Leu Glu Asp Lys Asn Ser Lys Glu Lys Phe Thr Leu Phe 
            100                 105                 110         


Asn Asp Asp Asn Tyr Lys Asp Tyr Asp Phe Tyr Lys Gln Tyr Pro Thr 
        115                 120                 125             


Ile Phe His Leu Arg Asp Glu Leu Ile Lys Asn Pro Glu Lys Lys Asp 
    130                 135                 140                 


Ile Arg Leu Ile Tyr Leu Ala Leu His Ser Ile Phe Lys Ser Arg Gly 
145                 150                 155                 160 


His Phe Leu Phe Glu Gly Gln Asn Leu Lys Glu Ile Lys Asn Phe Glu 
                165                 170                 175     


Thr Leu Tyr Asn Asn Leu Ile Ser Phe Leu Glu Asp Asn Gly Ile Asn 
            180                 185                 190         


Lys Ser Ile Asp Lys Asp Asn Ile Lys Lys Leu Glu Lys Ile Ile Cys 
        195                 200                 205             


Asp Ser Gly Lys Gly Leu Lys Asp Lys Glu Lys Glu Phe Lys Glu Ile 
    210                 215                 220                 


Phe Asn Ser Asp Lys Gln Leu Val Ala Ile Phe Lys Leu Ser Val Gly 
225                 230                 235                 240 


Ser Ser Val Ser Leu Asn Asp Leu Phe Asp Thr Asp Glu Tyr Lys Lys 
                245                 250                 255     


Glu Glu Val Glu Lys Glu Lys Ile Ser Phe Arg Glu Gln Ile Tyr Glu 
            260                 265                 270         


Asp Asp Lys Pro Ile Tyr Tyr Ser Ile Leu Gly Glu Lys Ile Glu Leu 
        275                 280                 285             


Leu Asp Ile Ala Lys Ser Phe Tyr Asp Phe Met Val Leu Asn Asn Ile 
    290                 295                 300                 


Leu Ser Asp Ser Asn Tyr Ile Ser Glu Ala Lys Val Lys Leu Tyr Glu 
305                 310                 315                 320 


Glu His Lys Lys Asp Leu Lys Asn Leu Lys Tyr Ile Ile Arg Lys Tyr 
                325                 330                 335     


Asn Lys Glu Asn Tyr Asp Lys Leu Phe Lys Asp Lys Asn Glu Asn Asn 
            340                 345                 350         


Tyr Pro Ala Tyr Ile Gly Leu Asn Lys Glu Lys Gly Lys Lys Glu Val 
        355                 360                 365             


Val Glu Lys Ser Gly Leu Lys Ile Asp Asp Leu Ile Lys Val Ile Lys 
    370                 375                 380                 


Gly Tyr Leu Pro Lys Pro Glu Arg Ile Glu Glu Lys Asp Lys Ile Ile 
385                 390                 395                 400 


Phe Asn Glu Ile Leu Asn Lys Ile Glu Leu Lys Thr Ile Leu Pro Lys 
                405                 410                 415     


Gln Arg Ile Ser Asp Asn Gly Thr Leu Pro Tyr Gln Ile His Glu Val 
            420                 425                 430         


Glu Leu Glu Lys Ile Leu Glu Asn Gln Ser Lys Tyr Tyr Asp Phe Leu 
        435                 440                 445             


Asn Tyr Glu Glu Asn Gly Val Ser Thr Lys Asp Lys Leu Leu Lys Thr 
    450                 455                 460                 


Phe Lys Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Ser Tyr His 
465                 470                 475                 480 


Lys Asp Lys Gly Gly Asn Ser Trp Ile Val Arg Lys Glu Glu Gly Lys 
                485                 490                 495     


Ile Leu Pro Trp Asn Phe Glu Gln Lys Val Asp Ile Glu Lys Ser Ala 
            500                 505                 510         


Glu Glu Phe Ile Lys Arg Met Thr Asn Lys Cys Thr Tyr Leu Asn Gly 
        515                 520                 525             


Glu Asp Val Ile Pro Lys Asp Ser Phe Leu Tyr Ser Glu Tyr Ile Ile 
    530                 535                 540                 


Leu Asn Glu Leu Asn Lys Val Gln Val Asn Asp Glu Phe Leu Asn Glu 
545                 550                 555                 560 


Glu Asn Lys Arg Lys Ile Ile Asp Glu Leu Phe Lys Glu Asn Lys Lys 
                565                 570                 575     


Val Ser Glu Lys Lys Phe Lys Glu Tyr Leu Leu Val Asn Gln Ile Ala 
            580                 585                 590         


Asn Arg Thr Val Glu Leu Lys Gly Ile Lys Asp Ser Phe Asn Ser Asn 
        595                 600                 605             


Tyr Val Ser Tyr Ile Lys Phe Lys Asp Ile Phe Gly Glu Lys Leu Asn 
    610                 615                 620                 


Leu Asp Ile Tyr Lys Glu Ile Ser Glu Lys Ser Ile Leu Trp Lys Cys 
625                 630                 635                 640 


Leu Tyr Gly Asp Asp Lys Lys Ile Phe Glu Lys Lys Ile Lys Asn Glu 
                645                 650                 655     


Tyr Gly Asp Ile Leu Asn Lys Asp Glu Ile Lys Lys Ile Asn Ser Phe 
            660                 665                 670         


Lys Phe Asn Thr Trp Gly Arg Leu Ser Glu Lys Leu Leu Thr Gly Ile 
        675                 680                 685             


Glu Phe Ile Asn Leu Glu Thr Gly Glu Cys Tyr Ser Ser Val Met Glu 
    690                 695                 700                 


Ala Leu Arg Arg Thr Asn Tyr Asn Leu Met Glu Leu Leu Ser Ser Lys 
705                 710                 715                 720 


Phe Thr Leu Gln Glu Ser Ile Asp Asn Gly Asn Lys Glu Met Asn Glu 
                725                 730                 735     


Val Ser Tyr Arg Asp Leu Ile Glu Glu Ser Tyr Val Ser Pro Ser Leu 
            740                 745                 750         


Lys Arg Ala Ile Leu Gln Thr Leu Lys Ile Tyr Glu Glu Ile Lys Lys 
        755                 760                 765             


Ile Thr Gly Arg Val Pro Lys Lys Val Phe Ile Glu Met Ala Arg Gly 
    770                 775                 780                 


Gly Asp Glu Thr Met Lys Asn Lys Lys Ile Pro Ala Arg Gln Glu Gln 
785                 790                 795                 800 


Leu Lys Lys Leu Tyr Asp Ser Cys Gly Asn Asp Ile Ala Asn Phe Ser 
                805                 810                 815     


Ile Asp Ile Lys Lys Met Lys Ser Ser Leu Ser Ser Tyr Asp Asn Asn 
            820                 825                 830         


Ser Leu Arg Gln Lys Lys Leu Tyr Leu Tyr Tyr Leu Gln Phe Gly Lys 
        835                 840                 845             


Cys Met Tyr Thr Gly Arg Glu Ile Asp Leu Asp Arg Leu Leu Gln Asn 
    850                 855                 860                 


Asn Asp Thr Tyr Asp Ile Asp His Ile Tyr Pro Arg Ser Lys Val Ile 
865                 870                 875                 880 


Lys Asp Asp Ser Phe Asp Asn Leu Val Leu Val Leu Lys Asn Glu Asn 
                885                 890                 895     


Ala Glu Lys Ser Asn Glu Tyr Pro Val Lys Lys Glu Ile Gln Glu Lys 
            900                 905                 910         


Met Lys Ser Phe Trp Arg Phe Leu Lys Glu Lys Asn Phe Ile Ser Asp 
        915                 920                 925             


Glu Lys Tyr Lys Arg Leu Thr Gly Lys Asp Asp Phe Glu Leu Arg Gly 
    930                 935                 940                 


Phe Met Ala Arg Gln Leu Val Asn Val Arg Gln Thr Thr Lys Glu Val 
945                 950                 955                 960 


Gly Lys Ile Leu Gln Gln Ile Glu Pro Glu Ile Lys Ile Val Tyr Ser 
                965                 970                 975     


Lys Ala Glu Ile Ala Ser Ser Phe Arg Glu Met Phe Asp Phe Ile Lys 
            980                 985                 990         


Val Arg Glu Leu Asn Asp Thr His  His Ala Lys Asp Ala  Tyr Leu Asn 
        995                 1000                 1005             


Ile Val  Ala Gly Asn Val Tyr  Asn Thr Lys Phe Thr  Glu Lys Pro 
    1010                 1015                 1020             


Tyr Arg  Tyr Leu Gln Glu Ile  Lys Glu Asn Tyr Asp  Val Lys Lys 
    1025                 1030                 1035             


Ile Tyr  Asn Tyr Asp Ile Lys  Asn Ala Trp Asp Lys  Glu Asn Ser 
    1040                 1045                 1050             


Leu Glu  Ile Val Lys Lys Asn  Met Lys Lys Asn Thr  Val Asn Ile 
    1055                 1060                 1065             


Thr Arg  Phe Ile Lys Glu Glu  Lys Gly Gln Leu Phe  Asp Leu Asn 
    1070                 1075                 1080             


Pro Ile  Lys Lys Gly Glu Thr  Ser Asn Glu Ile Ile  Ser Ile Lys 
    1085                 1090                 1095             


Pro Lys  Leu Tyr Asn Gly Lys  Glu Glu Lys Leu Asn  Glu Lys Tyr 
    1100                 1105                 1110             


Gly Tyr  Tyr Lys Ser Leu Asn  Pro Ala Tyr Phe Leu  Tyr Val Glu 
    1115                 1120                 1125             


His Lys  Glu Lys Asn Lys Arg  Ile Lys Ser Phe Glu  Arg Val Asn 
    1130                 1135                 1140             


Leu Val  Asp Val Asn Asn Ile  Lys Asp Glu Lys Ser  Leu Val Lys 
    1145                 1150                 1155             


Tyr Leu  Ile Glu Asn Lys Lys  Leu Val Glu Pro Arg  Leu Ile Lys 
    1160                 1165                 1170             


Lys Val  Tyr Lys Arg Gln Val  Ile Leu Ile Asn Asp  Tyr Pro Tyr 
    1175                 1180                 1185             


Ser Ile  Val Ala Leu Asp Ser  Asn Lys Leu Met Asp  Phe Glu Asn 
    1190                 1195                 1200             


Leu Lys  Pro Leu Phe Leu Glu  Asn Lys Tyr Glu Lys  Ile Leu Lys 
    1205                 1210                 1215             


Asn Val  Ile Lys Phe Leu Glu  Asp Asn Gln Gly Lys  Ser Glu Glu 
    1220                 1225                 1230             


Asn Tyr  Lys Phe Ile Tyr Leu  Lys Lys Lys Asp Arg  Tyr Glu Lys 
    1235                 1240                 1245             


Asn Glu  Thr Leu Glu Ser Val  Lys Asp Arg Tyr Asn  Leu Glu Phe 
    1250                 1255                 1260             


Asn Glu  Met Tyr Asp Lys Phe  Leu Glu Lys Leu Asp  Ser Lys Asp 
    1265                 1270                 1275             


Tyr Lys  Asn Tyr Ile Asn Asn  Lys Lys Tyr Lys Asn  Leu Leu Asp 
    1280                 1285                 1290             


Val Lys  Glu Lys Phe Ile Lys  Leu Asn Leu Phe Asp  Lys Ala Phe 
    1295                 1300                 1305             


Thr Leu  Lys Ser Phe Leu Asp  Leu Phe Asn Arg Lys  Thr Met Ala 
    1310                 1315                 1320             


Asp Phe  Ser Lys Val Gly Leu  Thr Lys Tyr Leu Gly  Lys Ile Gln 
    1325                 1330                 1335             


Lys Ile  Ser Ser Asn Val Leu  Ser Lys Asn Glu Leu  Tyr Leu Leu 
    1340                 1345                 1350             


Glu Glu  Ser Val Thr Gly Leu  Phe Val Lys Lys Ile  Lys Leu 
    1355                 1360                 1365         


<210> 236
<211> 1367
<212> PRT
<213> Fusobacterium sp.


<220>
<223> Fusobacterium sp. 3_1_36A2

<400> 236
Met Lys Lys Gln Lys Phe Ser Asp Tyr Tyr Leu Gly Phe Asp Ile Gly 
1               5                   10                  15      


Thr Asn Ser Val Gly Trp Cys Val Thr Asp Leu Asp Tyr Asn Val Leu 
            20                  25                  30          


Arg Phe Asn Lys Lys Asp Met Trp Gly Ser Arg Leu Phe Asp Glu Ala 
        35                  40                  45              


Lys Thr Ala Ala Glu Arg Arg Val Gln Arg Asn Ser Arg Arg Arg Leu 
    50                  55                  60                  


Lys Arg Arg Lys Trp Arg Leu Asn Leu Leu Glu Glu Ile Phe Ser Asp 
65                  70                  75                  80  


Glu Ile Met Lys Ile Asp Ser Asn Phe Phe Arg Arg Leu Lys Glu Ser 
                85                  90                  95      


Ser Leu Trp Leu Glu Asp Lys Asn Ser Lys Glu Lys Phe Thr Leu Phe 
            100                 105                 110         


Asn Asp Asp Asn Tyr Lys Asp Tyr Asp Phe Tyr Lys Gln Tyr Pro Thr 
        115                 120                 125             


Ile Phe His Leu Arg Asp Glu Leu Ile Lys Asn Pro Glu Lys Lys Asp 
    130                 135                 140                 


Ile Arg Leu Ile Tyr Leu Ala Leu His Ser Ile Phe Lys Ser Arg Gly 
145                 150                 155                 160 


His Phe Leu Phe Glu Gly Gln Asn Leu Lys Glu Ile Lys Asn Phe Glu 
                165                 170                 175     


Thr Leu Tyr Asn Asn Leu Ile Ser Phe Leu Glu Asp Asn Gly Ile Asn 
            180                 185                 190         


Lys Ser Ile Asp Lys Asp Asn Ile Lys Lys Leu Glu Lys Ile Ile Cys 
        195                 200                 205             


Asp Ser Gly Lys Gly Leu Lys Asp Lys Glu Lys Glu Phe Lys Glu Ile 
    210                 215                 220                 


Phe Asn Ser Asp Lys Gln Leu Val Ala Ile Phe Lys Leu Ser Val Gly 
225                 230                 235                 240 


Ser Ser Val Ser Leu Asn Asp Leu Phe Asp Thr Asp Glu Tyr Lys Lys 
                245                 250                 255     


Glu Glu Val Glu Lys Glu Lys Ile Ser Phe Arg Glu Gln Ile Tyr Glu 
            260                 265                 270         


Asp Asp Lys Pro Ile Tyr Tyr Ser Ile Leu Gly Glu Lys Ile Glu Leu 
        275                 280                 285             


Leu Asp Ile Ala Lys Ser Phe Tyr Asp Phe Met Val Leu Asn Asn Ile 
    290                 295                 300                 


Leu Ser Asp Ser Asn Tyr Ile Ser Glu Ala Lys Val Lys Leu Tyr Glu 
305                 310                 315                 320 


Glu His Lys Lys Asp Leu Lys Asn Leu Lys Tyr Ile Ile Arg Lys Tyr 
                325                 330                 335     


Asn Lys Glu Asn Tyr Asp Lys Leu Phe Lys Asp Lys Asn Glu Asn Asn 
            340                 345                 350         


Tyr Pro Ala Tyr Ile Gly Leu Asn Lys Glu Lys Gly Lys Lys Glu Val 
        355                 360                 365             


Val Glu Lys Ser Gly Leu Lys Ile Asp Asp Leu Ile Lys Val Ile Lys 
    370                 375                 380                 


Gly Tyr Leu Pro Lys Pro Glu Arg Ile Glu Glu Lys Asp Lys Thr Ile 
385                 390                 395                 400 


Phe Asn Glu Ile Leu Asn Lys Ile Glu Leu Lys Thr Ile Leu Pro Lys 
                405                 410                 415     


Gln Arg Ile Ser Asp Asn Gly Thr Leu Pro Tyr Gln Ile His Glu Val 
            420                 425                 430         


Glu Leu Glu Lys Ile Leu Glu Asn Gln Ser Lys Tyr Tyr Asp Phe Leu 
        435                 440                 445             


Asn Tyr Glu Glu Asn Gly Val Ser Thr Lys Asp Lys Leu Leu Lys Thr 
    450                 455                 460                 


Phe Lys Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Ser Tyr His 
465                 470                 475                 480 


Lys Asp Lys Gly Gly Asn Ser Trp Ile Val Arg Lys Glu Glu Gly Lys 
                485                 490                 495     


Ile Leu Pro Trp Asn Phe Glu Gln Lys Val Asp Ile Glu Lys Ser Ala 
            500                 505                 510         


Glu Glu Phe Ile Lys Arg Met Thr Asn Lys Cys Thr Tyr Leu Asn Gly 
        515                 520                 525             


Glu Asp Val Ile Pro Lys Asp Ser Phe Leu Tyr Ser Glu Tyr Ile Ile 
    530                 535                 540                 


Leu Asn Glu Leu Asn Lys Val Gln Val Asn Asp Glu Phe Leu Asn Glu 
545                 550                 555                 560 


Glu Asn Lys Arg Lys Ile Ile Asp Glu Leu Phe Lys Glu Asn Lys Lys 
                565                 570                 575     


Val Ser Glu Lys Lys Phe Lys Glu Tyr Leu Leu Val Asn Gln Ile Ala 
            580                 585                 590         


Asn Arg Thr Val Glu Leu Lys Gly Ile Lys Asp Ser Phe Asn Ser Asn 
        595                 600                 605             


Tyr Val Ser Tyr Ile Lys Phe Lys Asp Ile Phe Gly Glu Lys Leu Asn 
    610                 615                 620                 


Leu Asp Ile Tyr Lys Glu Ile Ser Glu Lys Ser Ile Leu Trp Lys Cys 
625                 630                 635                 640 


Leu Tyr Gly Asp Asp Lys Lys Ile Phe Glu Lys Lys Ile Lys Asn Glu 
                645                 650                 655     


Tyr Gly Asp Ile Leu Asn Lys Asp Glu Ile Lys Lys Ile Asn Ser Phe 
            660                 665                 670         


Lys Phe Asn Thr Trp Gly Arg Leu Ser Glu Lys Leu Leu Thr Gly Ile 
        675                 680                 685             


Glu Phe Ile Asn Leu Glu Thr Gly Glu Cys Tyr Ser Ser Val Met Glu 
    690                 695                 700                 


Ala Leu Arg Arg Thr Asn Tyr Asn Leu Met Glu Leu Leu Ser Ser Lys 
705                 710                 715                 720 


Phe Thr Leu Gln Glu Ser Ile Asp Asn Gly Asn Lys Glu Met Asn Glu 
                725                 730                 735     


Val Ser Tyr Arg Asp Leu Ile Glu Glu Ser Tyr Val Ser Pro Ser Leu 
            740                 745                 750         


Lys Arg Ala Ile Leu Gln Thr Leu Lys Ile Tyr Glu Glu Ile Lys Lys 
        755                 760                 765             


Ile Thr Gly Arg Val Pro Lys Lys Val Phe Ile Glu Met Ala Arg Gly 
    770                 775                 780                 


Gly Asp Glu Thr Met Lys Asn Lys Lys Ile Pro Ala Arg Gln Glu Gln 
785                 790                 795                 800 


Leu Lys Lys Leu Tyr Asp Ser Cys Gly Asn Asp Ile Ala Asn Phe Ser 
                805                 810                 815     


Ile Asp Ile Lys Lys Met Lys Ser Ser Leu Ser Ser Tyr Asp Asn Asn 
            820                 825                 830         


Ser Leu Arg Gln Lys Lys Leu Tyr Leu Tyr Tyr Leu Gln Phe Gly Lys 
        835                 840                 845             


Cys Met Tyr Thr Gly Arg Glu Ile Asp Leu Asp Arg Leu Leu Gln Asn 
    850                 855                 860                 


Asn Asp Thr Tyr Asp Ile Asp His Ile Tyr Pro Arg Ser Lys Val Ile 
865                 870                 875                 880 


Lys Asp Asp Ser Phe Asp Asn Leu Val Leu Val Leu Lys Asn Glu Asn 
                885                 890                 895     


Ala Glu Lys Ser Asn Glu Tyr Pro Val Lys Lys Glu Ile Gln Glu Lys 
            900                 905                 910         


Met Lys Ser Phe Trp Arg Phe Leu Lys Glu Lys Asn Phe Ile Ser Asp 
        915                 920                 925             


Glu Lys Tyr Lys Arg Leu Thr Gly Lys Asp Asp Phe Glu Leu Arg Gly 
    930                 935                 940                 


Phe Met Ala Arg Gln Leu Val Asn Val Arg Gln Thr Thr Lys Glu Val 
945                 950                 955                 960 


Gly Lys Ile Leu Gln Gln Ile Glu Pro Glu Ile Lys Ile Val Tyr Ser 
                965                 970                 975     


Lys Ala Glu Ile Ala Ser Ser Phe Arg Glu Met Phe Asp Phe Ile Lys 
            980                 985                 990         


Val Arg Glu Leu Asn Asp Thr His  His Ala Lys Asp Ala  Tyr Leu Asn 
        995                 1000                 1005             


Ile Val  Ala Gly Asn Val Tyr  Asn Thr Lys Phe Thr  Glu Lys Pro 
    1010                 1015                 1020             


Tyr Arg  Tyr Leu Gln Glu Ile  Lys Glu Asn Tyr Asp  Val Lys Lys 
    1025                 1030                 1035             


Ile Tyr  Asn Tyr Asp Ile Lys  Asn Ala Trp Asp Lys  Glu Asn Ser 
    1040                 1045                 1050             


Leu Glu  Ile Val Lys Lys Asn  Met Lys Lys Asn Thr  Val Asn Ile 
    1055                 1060                 1065             


Thr Arg  Phe Ile Lys Glu Glu  Lys Gly Gln Leu Phe  Asp Leu Asn 
    1070                 1075                 1080             


Pro Ile  Lys Lys Gly Glu Thr  Ser Asn Glu Ile Ile  Ser Ile Lys 
    1085                 1090                 1095             


Pro Lys  Leu Tyr Asn Gly Lys  Glu Glu Lys Leu Asn  Glu Lys Tyr 
    1100                 1105                 1110             


Gly Tyr  Tyr Lys Ser Leu Asn  Pro Ala Tyr Phe Leu  Tyr Val Glu 
    1115                 1120                 1125             


His Lys  Glu Lys Asn Lys Arg  Ile Lys Ser Phe Glu  Arg Val Asn 
    1130                 1135                 1140             


Leu Val  Asp Val Asn Asn Ile  Lys Asp Glu Lys Ser  Leu Val Lys 
    1145                 1150                 1155             


Tyr Leu  Ile Glu Asn Lys Lys  Leu Val Glu Pro Arg  Leu Ile Lys 
    1160                 1165                 1170             


Lys Val  Tyr Lys Arg Gln Val  Ile Leu Ile Asn Asp  Tyr Pro Tyr 
    1175                 1180                 1185             


Ser Ile  Val Ala Leu Asp Ser  Asn Lys Leu Met Asp  Phe Glu Asn 
    1190                 1195                 1200             


Leu Lys  Pro Leu Phe Leu Glu  Asn Lys Tyr Glu Lys  Ile Leu Lys 
    1205                 1210                 1215             


Asn Val  Ile Lys Phe Leu Glu  Asp Asn Gln Gly Lys  Ser Glu Glu 
    1220                 1225                 1230             


Asn Tyr  Lys Phe Ile Tyr Leu  Lys Lys Lys Asp Arg  Tyr Glu Lys 
    1235                 1240                 1245             


Asn Glu  Thr Leu Glu Ser Val  Lys Asp Arg Tyr Asn  Leu Glu Phe 
    1250                 1255                 1260             


Asn Glu  Met Tyr Asp Lys Phe  Leu Glu Lys Leu Asp  Ser Lys Asp 
    1265                 1270                 1275             


Tyr Lys  Asn Tyr Ile Asn Asn  Lys Lys Tyr Lys Asn  Leu Leu Asp 
    1280                 1285                 1290             


Val Lys  Glu Lys Phe Ile Lys  Leu Asn Leu Phe Asp  Lys Ala Phe 
    1295                 1300                 1305             


Thr Leu  Lys Ser Phe Leu Asp  Leu Phe Asn Arg Lys  Thr Met Ala 
    1310                 1315                 1320             


Asp Phe  Ser Lys Val Gly Leu  Thr Lys Tyr Leu Gly  Lys Ile Gln 
    1325                 1330                 1335             


Lys Ile  Ser Ser Asn Val Leu  Ser Lys Asn Glu Leu  Tyr Leu Leu 
    1340                 1345                 1350             


Glu Glu  Ser Val Thr Gly Leu  Phe Val Lys Lys Ile  Lys Leu 
    1355                 1360                 1365         


<210> 237
<211> 1391
<212> PRT
<213> Galbibacter sp.


<220>
<223> Galbibacter sp. ck-I2-15

<400> 237
Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Lys Glu Ala Glu Asn Glu Asn Glu Val Ser Asp Ile Ile 
            20                  25                  30          


Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Leu Thr Asn 
        35                  40                  45              


Phe Glu Gly Gly Lys Ala Tyr Ser Asn Asn Ala Glu Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Ala Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Glu Asn 
65                  70                  75                  80  


Leu Ile Glu Ile Leu Leu Lys Asn Gly Leu Ile Asn Lys Asp Thr Ala 
                85                  90                  95      


Leu Thr Glu Val Gly Lys Glu Thr Thr His Gln Thr Leu Lys Leu Arg 
            100                 105                 110         


Ser Lys Ser Ala Asn Glu Lys Val Ser Leu Glu Asp Leu Ala Lys Ile 
        115                 120                 125             


Leu Leu Ser Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Val 
    130                 135                 140                 


Asn Ala Glu Asp Asp Gly Val Ala Ile Asp Gly Met Glu Val Ala Lys 
145                 150                 155                 160 


Leu Leu Tyr Asp Glu Asn Met Thr Pro Gly Glu Tyr Val Leu Arg Leu 
                165                 170                 175     


Leu Glu Ser Gly Lys Lys His Leu Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Glu Glu Phe Asn Leu Val Trp Lys Lys Gln Ser Glu Phe Tyr Pro 
        195                 200                 205             


Leu Ile Leu Thr Lys Glu Leu Phe Phe Glu Leu His Gly Lys Asn Lys 
    210                 215                 220                 


Ser Gln Thr Trp Ala Ile Cys Lys Glu Pro Leu Gly Ile Val Gly Val 
225                 230                 235                 240 


Lys Leu Lys Gly Ser Ala Lys Glu Gln Lys Phe Ala Arg Tyr Arg Leu 
                245                 250                 255     


Arg Lys Glu Ala Leu Thr Gln Gln Ile Glu Leu Glu His Leu Ala Ile 
            260                 265                 270         


Val Leu Gln Asp Ile Asn Asn Asp Ser Asn Lys Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Phe Phe Asn Lys Glu Thr 
    290                 295                 300                 


Val Gly Gln Tyr Gln Tyr Lys Gln Leu Gln Lys Asp Pro Asn Thr Ser 
305                 310                 315                 320 


Leu Lys Asn Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Val Ile Trp Arg Asn Gln Ala Lys Phe Tyr Pro Gln Leu Thr Asn Glu 
            340                 345                 350         


Leu Lys Gln Glu Ile Arg Asp Val Val Ile Phe Tyr Gln Arg Lys Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Ile Ser Phe Cys Gln Phe Glu Ser Thr Gln 
    370                 375                 380                 


Gln Asn Tyr Val Glu Lys Glu Thr Gly Lys Thr Lys Ile Arg Thr Ile 
385                 390                 395                 400 


Gly Arg Arg Val Ile Pro Arg Ser Ser Pro Leu Phe Gln Glu Phe Lys 
                405                 410                 415     


Ile Trp Gln Ser Leu Asn Asn Leu Lys Phe Val Asn Ser Glu Ser Asn 
            420                 425                 430         


Gln Ile Ile Gln Phe Ile Glu Leu Glu Asp Asp Val Lys Lys Val Val 
        435                 440                 445             


Phe Asp Glu Leu Asn Leu Arg Gly Asp Leu Lys Pro Asn Gln Val Leu 
    450                 455                 460                 


Lys Ile Leu Ser Lys Tyr Met Lys Ile Gly Lys Leu Thr Gln Trp Lys 
465                 470                 475                 480 


Cys Asn Leu Glu Glu Ile Glu Gly Asn Arg Thr Asn Ser Ala Leu Tyr 
                485                 490                 495     


Asn Val Phe Gln Met Ile Ala Glu Glu Glu Gly Tyr Gly Phe Asn Trp 
            500                 505                 510         


Gly Lys Lys Ser Ala Leu Glu Ile Lys Ser Glu Leu Lys Ala Ile Phe 
        515                 520                 525             


Ser Ser Ile Gly Ile Asn Asp Ser Ile Leu Asp Phe Asp Phe Ser Lys 
    530                 535                 540                 


Lys Leu Asp Gln Gln Leu Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser 
545                 550                 555                 560 


Ala Glu Glu Gly Asn Ser Lys Ile Thr Glu Glu Asp Lys Phe Thr Tyr 
                565                 570                 575     


Gly Asn Thr Gly Val Ala Leu Lys Lys Lys Leu His Leu Lys Phe Gly 
            580                 585                 590         


Phe Lys Pro Glu Tyr Ser Thr Leu Ile Ser Asn Leu Arg Phe Thr Ser 
        595                 600                 605             


Asp Tyr Gly Asn Leu Ser Ser Lys Ala Ile Ser Lys Ile Leu Pro Phe 
    610                 615                 620                 


Leu Arg Asp Gly Ser Asp Tyr Ser Lys Ala Cys Gln Tyr Ala Gly Tyr 
625                 630                 635                 640 


Asn His Ser Asn Ser Leu Ser Ala Asp Glu Leu Asp Asn Arg Glu Leu 
                645                 650                 655     


Lys Pro Lys Leu Glu Leu Leu Lys Lys Asn Ser Leu Arg Asn Pro Val 
            660                 665                 670         


Val Glu Lys Ile Leu Asn Gln Met Val Asn Val Val Asn Gln Val Ile 
        675                 680                 685             


Asp Asn Tyr Gly Lys Pro Asp Glu Val Arg Ile Glu Leu Ala Arg Glu 
    690                 695                 700                 


Leu Lys Lys Ser Ala Lys Glu Arg Ser Gln Met Thr Lys Asn Ile Ser 
705                 710                 715                 720 


Asp Ala Thr Arg Arg Asn Ala Glu Ile Lys Lys Tyr Leu Ser Lys Glu 
                725                 730                 735     


Phe Gly Ile Pro Asn Pro Thr Lys Gly Asp Val Ile Arg Tyr Arg Leu 
            740                 745                 750         


Trp Glu Glu Leu Ala Ser Asn Gly Tyr Lys Asp Leu Phe Arg Asp Lys 
        755                 760                 765             


Tyr Ile Pro Lys Glu Lys Leu Phe Ser Asn Glu Ile Asp Ile Glu His 
    770                 775                 780                 


Ile Ile Pro Lys Ala Leu Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr 
785                 790                 795                 800 


Leu Ala Phe Lys Val Asp Asn Leu Lys Lys Ala Asp Arg Thr Ala Phe 
                805                 810                 815     


Asp Phe Met Ser Thr Asp Phe Ser Lys Asp Val Asp Ser Tyr Ile Gly 
            820                 825                 830         


Arg Ile Glu Thr Leu His Lys Asp Gly Lys Ile Ser Ser Ser Lys Tyr 
        835                 840                 845             


Lys Lys Leu Met Ile Pro Lys Ser Lys Leu Val Asp Gly Phe Ile Glu 
    850                 855                 860                 


Arg Asp Leu Arg Asn Thr Gln Tyr Ile Ala Lys Gln Ala Arg Lys Met 
865                 870                 875                 880 


Leu Leu Glu Val Phe Lys Thr Val Val Pro Thr Thr Gly Lys Ile Thr 
                885                 890                 895     


Asp Lys Leu Arg Glu Asp Trp Asp Leu Ile Asn Val Met Lys Glu Leu 
            900                 905                 910         


Asn Phe Pro Lys Tyr Lys Ala Leu Gly Leu Thr Lys Lys Ile Glu Arg 
        915                 920                 925             


Phe Asp Val Gly Ser Glu Lys Ile Lys Ser Ile Asn Val Ile Glu Gly 
    930                 935                 940                 


Trp Ser Lys Arg Asn Asp His Arg His His Ala Met Asp Ala Leu Ala 
945                 950                 955                 960 


Val Ala Phe Thr Thr His Asn His Ile Gln Tyr Leu Asn Tyr Leu Asn 
                965                 970                 975     


Ala Arg Lys Asp Ile His His Glu Met His Gly Thr Ile Lys Ser Ile 
            980                 985                 990         


Glu Asn Gln Ile Ile Gly Lys Asp  Val Met Gly Lys Arg  Arg Phe Ile 
        995                 1000                 1005             


Pro Pro  Ile Ser Asp Leu Arg  Met Lys Ala Lys Leu  Gln Ile Glu 
    1010                 1015                 1020             


Ser Ile  Leu Ile Ser Phe Lys  Asn Lys Asn Lys Val  Val Thr Trp 
    1025                 1030                 1035             


Ser Val  Asn Lys Thr Lys Leu  Lys Gly Lys Asp Asn  Tyr Asn Lys 
    1040                 1045                 1050             


Arg Arg  Gln Leu Thr Pro Arg  Gly Gln Leu His Lys  Glu Thr Val 
    1055                 1060                 1065             


Tyr Gly  Lys Ile Lys Leu Ile  Asp Pro Lys Pro Leu  Lys Leu Asn 
    1070                 1075                 1080             


Asn Lys  Phe Thr Leu Val Arg  Ala Ser Met Ile Val  Asp Lys Val 
    1085                 1090                 1095             


His Arg  Glu Ile Val Leu Gln  His Leu Ser Lys Tyr  Asp Asn Asn 
    1100                 1105                 1110             


Ser Glu  Val Ala Phe Asp Ser  Lys Thr Ile Lys Ile  Asp Pro Ile 
    1115                 1120                 1125             


Leu Ile  Glu Gly Ile Gly Leu  Lys Glu Val Val Cys  Tyr Glu Asp 
    1130                 1135                 1140             


Val Phe  Lys Ile Arg Lys Lys  Ile Ser Gly Asp Asn  Phe Lys Asn 
    1145                 1150                 1155             


Glu Lys  His Leu Glu Lys Val  Ile Asp Glu Lys Val  Lys Gln Ile 
    1160                 1165                 1170             


Leu Lys  Asp Arg Val Ile Lys  Phe Gln Gly Asn Phe  Lys Glu Ala 
    1175                 1180                 1185             


Phe Ser  Asn Leu Glu Glu Asn  Pro Ile Trp Leu Asn  Lys Ser Lys 
    1190                 1195                 1200             


Gly Ile  Ala Val Lys Ser Val  Ala Ile Lys Gly Val  Asn Asn Ala 
    1205                 1210                 1215             


Glu Ser  Leu His Glu Gly Lys  Asp His Phe Gly Asp  Gln Ile Leu 
    1220                 1225                 1230             


Asp Lys  Asn Lys Lys Gln Ile  Pro Val Asp Phe Val  Ser Thr Gly 
    1235                 1240                 1245             


Asn Asn  His His Val Gly Ile  Tyr Glu Asp Lys Asp  Gly Asn Leu 
    1250                 1255                 1260             


Gln Glu  Arg Val Val Ser Phe  Phe Glu Ala Val Thr  Arg Val Asn 
    1265                 1270                 1275             


Glu Gly  Leu Pro Ile Ile Asp  Lys Thr Tyr Asn Ser  Asp Ile Gly 
    1280                 1285                 1290             


Trp Lys  Phe Lys Phe Thr Met  Lys Gln Asn Glu Met  Phe Val Phe 
    1295                 1300                 1305             


Pro Ser  Asp Asp Phe Asp Pro  Asn Glu Phe Asp Leu  Thr Asp Gly 
    1310                 1315                 1320             


Lys Asn  Ala Ala Lys Ile Ser  Pro Asn Leu Tyr Arg  Val Gln Lys 
    1325                 1330                 1335             


Ile Ala  Thr Lys Asn Tyr Met  Phe Arg His His Leu  Glu Thr Val 
    1340                 1345                 1350             


Val Thr  Asn Asp Leu Glu Phe  Thr Tyr Lys Ser Ile  Arg Ser Thr 
    1355                 1360                 1365             


Gly Trp  Leu Arg Asn Leu Val  Lys Val Arg Ile Asn  His Leu Gly 
    1370                 1375                 1380             


Glu Ile  Val Tyr Val Gly Glu  Tyr 
    1385                 1390     


<210> 238
<211> 1025
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      gamma proteobacterium HdN1 polypeptide

<400> 238
Met Gly Gly Tyr Met Pro Gln Leu Met Arg Tyr Arg Leu Ala Leu Asp 
1               5                   10                  15      


Ile Gly Ser Thr Ser Ile Gly Trp Ala Met Ile Arg Leu Ser Met Gln 
            20                  25                  30          


Asn Glu Pro Ile Ala Ile Ile Arg Met Gly Val Arg Ile Phe Ser Asp 
        35                  40                  45              


Gly Arg Asn Pro Lys Asp Gly Ser Ser Leu Ala Val Thr Arg Arg Val 
    50                  55                  60                  


Ala Arg Gln Met Arg Arg Arg Arg Asp Arg Leu Leu Lys Arg Lys Thr 
65                  70                  75                  80  


Arg Leu Leu Asn Ala Leu Val Gln Lys Lys Phe Phe Pro Glu Asp Ala 
                85                  90                  95      


Asp Ala Arg Lys Ala Leu Val Val Leu Asn Pro Tyr Glu Leu Arg Lys 
            100                 105                 110         


Glu Gly Leu Tyr Arg Gln Leu Ser Gly Pro Glu Phe Gly Arg Ala Leu 
        115                 120                 125             


Phe His Ile Ser Gln Arg Arg Gly Phe Leu Ser Asn Arg Lys Thr Asp 
    130                 135                 140                 


Lys Lys Asp Asn Asp Ser Ser Val Leu Lys Lys Ala Ile Val Asp Leu 
145                 150                 155                 160 


Arg Gln Gln Leu Glu Val Glu Asn Cys Gln Thr Ile Gly Glu Trp Leu 
                165                 170                 175     


Phe Lys Gln Gln Gln Ser Gly Lys Ser Val Arg Ala Arg Leu Arg Gly 
            180                 185                 190         


Lys Thr Gln Lys Asp Lys Ala Tyr Asp Phe Tyr Ile Asp Arg Ala Met 
        195                 200                 205             


Ile Ala His Glu Phe Asp Thr Leu Trp Val Ser Gln Ala Lys Tyr Asp 
    210                 215                 220                 


Pro Leu Leu Phe Asn Glu Asp Ala Arg Ala Ile Leu Arg Asp Ile Leu 
225                 230                 235                 240 


Leu Tyr Gln Arg Pro Leu Lys Pro Val Lys Pro Gly Arg Cys Thr Leu 
                245                 250                 255     


Ile Pro Asp Glu Ser Arg Ala Pro Leu Ala Leu Pro Leu Thr Gln Gln 
            260                 265                 270         


Ala Arg Ile Tyr Gln Glu Leu Asn His Leu Arg Ile Thr Thr Pro Ala 
        275                 280                 285             


Leu Gly Ala Gln Ala Leu Thr Val Ala Gln Arg Asn Thr Ile Ala Ala 
    290                 295                 300                 


Leu Leu Glu Lys Ser Asp Val Thr Phe Val Lys Ile Ala Lys Ala Leu 
305                 310                 315                 320 


Gly Leu Thr Ser Thr Thr Glu Phe Asn Leu Gln Asp Ile Lys Arg Asp 
                325                 330                 335     


Arg Leu Lys Gly Asn Ala Thr Ala Ile Ile Leu Ala Arg Asn Gln Tyr 
            340                 345                 350         


Phe Gly Arg Arg Trp His Asp Phe Asn Ala Asp Leu Gln Asn Leu Ile 
        355                 360                 365             


Val Asp Lys Leu Val Asn Glu Gly Ser Glu Thr Ala Leu Ile Glu Trp 
    370                 375                 380                 


Leu Lys Ala Asn Thr Asp Val Asp Glu Ser Ala Ala Glu Arg Val Ser 
385                 390                 395                 400 


Gly Val Thr Leu Pro Glu Gly Tyr Gly Ser Leu Ser Val Ala Ala Leu 
                405                 410                 415     


Arg Arg Leu Leu Pro Ala Leu Lys Glu Asp Val Val Val Tyr Ser Glu 
            420                 425                 430         


Ala Val Lys Arg Ala Gly Phe Asp Ser His Ser Ala Leu Ser Leu Ile 
        435                 440                 445             


Glu Gln Thr Gly Glu Leu Tyr Gln Glu Leu Pro Tyr Tyr Gly Glu Val 
    450                 455                 460                 


Leu Gln Arg His Val Gly Phe Gly Ser Gly Asp Pro Asn Asp Ser Pro 
465                 470                 475                 480 


Glu Arg Arg Phe Gly Lys Ile Ala Asn Pro Thr Val His Ile Gly Leu 
                485                 490                 495     


Asn Glu Leu Arg Lys Ile Ile Asn Ala Leu Ile Lys Arg Tyr Gly Asn 
            500                 505                 510         


Pro Ala Glu Val Val Val Glu Leu Ala Arg Asp Leu Lys Leu Ser Arg 
        515                 520                 525             


Glu Lys Arg Lys Glu Ile Gln Glu Glu Gln Lys Gln Arg Gln Asp Arg 
    530                 535                 540                 


Asn Glu Lys Arg Ile Lys Asp Ala Cys Glu Ile Leu Gly Ile Asp Pro 
545                 550                 555                 560 


Leu Val Ile Asp Arg Gly Lys Arg Arg Glu Ile Ser Gln Lys Met Gln 
                565                 570                 575     


Leu Trp Asp Glu Leu Asn Pro Lys Asp Ala Ala Asn Arg Arg Cys Pro 
            580                 585                 590         


Tyr Thr Gly Asp Gln Ile Ser Ile Glu Lys Leu Leu Ser Ala Glu Val 
        595                 600                 605             


Glu Ile Glu His Ile Leu Pro Phe Ser Lys Thr Leu Asp Asp Ser Leu 
    610                 615                 620                 


Asn Asn Lys Thr Val Ala Met Arg Arg Ala Asn Arg Asp Lys Gly Asn 
625                 630                 635                 640 


Arg Thr Pro Tyr Glu Ala Phe Gly Glu Ser Leu Asn Pro Asp Tyr Asp 
                645                 650                 655     


Tyr Asp Ala Ile Leu Gln Arg Ala Ser Leu Met Pro Arg Glu Lys Arg 
            660                 665                 670         


Lys Arg Phe Ala Ser Asp Gly Tyr Gln Gln Trp Leu Arg Asp Asp Lys 
        675                 680                 685             


Asp Phe Leu Ser Arg Ala Leu Asn Asp Thr Ala Tyr Leu Ser Arg Ile 
    690                 695                 700                 


Ala Lys Glu Tyr Leu Thr Leu Ile Cys Pro Pro Asn Ser Val Arg Ala 
705                 710                 715                 720 


Ile Pro Gly Arg Met Thr Ala Gln Leu Arg Ala Met Phe Gly Leu Asn 
                725                 730                 735     


Arg Leu Leu Ser Glu Gly Gly Ile Lys Asn Arg Glu Asp His Arg His 
            740                 745                 750         


His Ala Ile Asp Ala Ala Val Ile Gly Val Thr Asp Gln Gly Leu Leu 
        755                 760                 765             


Gln Lys Phe Ser Arg Ala Ser Ala Arg Thr Arg Glu Leu Gln Leu Ser 
    770                 775                 780                 


Arg Leu Val Asp Asp Met Pro Leu Pro Trp Asp Thr Tyr Arg Glu His 
785                 790                 795                 800 


Val Thr Arg Ala Leu Glu His Leu Val Val Ser His Lys Pro Asp His 
                805                 810                 815     


Gly Tyr Gln Gly Lys Met His Glu Asp Thr Ala Trp Gly Leu Arg Asp 
            820                 825                 830         


Asn Gly Gln Val Thr Arg Arg Val Arg Ser Glu Asp Gly Gly Pro Arg 
        835                 840                 845             


Gln Arg Leu Leu Glu Asn Lys Asn Val Val Lys Ile Asn Ser Thr Arg 
    850                 855                 860                 


Asp Phe Ser Arg His Gly Ile Asp Glu Gln Gly Gln Val Asn Ala Tyr 
865                 870                 875                 880 


Lys Gly Tyr Val Gly Gly Ser Asn Tyr Cys Ile Glu Ile Trp Ile Asp 
                885                 890                 895     


Glu Lys Gly Lys Trp Asn Ser Asp Val Val Ser Thr Phe Gln Ala Tyr 
            900                 905                 910         


Gln Ile Val Arg Glu Leu Gly Glu Lys Ala Ala Trp Gln Lys Leu Arg 
        915                 920                 925             


Asn Pro Leu Leu Ser Leu Ser Ala Lys Pro Leu Val Met Arg Leu Ile 
    930                 935                 940                 


Ile Asp Asp Val Val Lys Met Gln Ile Ala Gly Gln Asn Lys Ile Met 
945                 950                 955                 960 


Arg Val Val Lys Ile Ala Gln Asn Gly Gln Ile Phe Phe Ala Glu His 
                965                 970                 975     


Asn Glu Ala Asn Val Asp Ala Arg Asp Lys Asp Lys Asn Asn Pro Phe 
            980                 985                 990         


Lys Tyr Ile Ser Lys Thr Ala Gly  Ser Leu Gln Lys Ala  Gly Gly Ile 
        995                 1000                 1005             


His Met  Ala Ile Ser Pro Ile  Gly Asp Ala Arg Pro  Val Arg Tyr 
    1010                 1015                 1020             


Gly Arg  
    1025 


<210> 239
<211> 1397
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      gamma proteobacterium HTCC5015 polypeptide

<400> 239
Met Thr Lys Asn Tyr Ile Ser Pro Ile Ala Ile Asp Leu Gly Ala Lys 
1               5                   10                  15      


Phe Thr Gly Val Ala Leu Tyr Gln Tyr Leu Glu Gly Ala Asp Cys Thr 
            20                  25                  30          


Gln Glu Val Ala Lys Gly Leu Leu Val Asp Asp Arg Gly Asn Val Thr 
        35                  40                  45              


Trp Ser Gln Glu Gly Arg Arg Gly Lys Arg His Gln Val Arg Gly Tyr 
    50                  55                  60                  


Lys Arg Arg Lys Met Ala Lys Arg Leu Leu Trp Leu Ile Leu Asp Ser 
65                  70                  75                  80  


Glu Tyr Gly Ile Lys Arg Glu Glu Val Thr Glu Pro Leu Leu Lys Phe 
                85                  90                  95      


Ile Asn Gly Leu Leu Asn Arg Arg Gly Tyr Thr Tyr Ile Ser Glu Glu 
            100                 105                 110         


Val Asp Glu Glu Ser Met Asn Val Ser Pro Leu Pro Phe Ser Glu Met 
        115                 120                 125             


Met Pro Asp Tyr Phe Asn Ser Ser Ala Pro Leu Leu Glu Gln Leu Ala 
    130                 135                 140                 


Lys Leu Leu Ser Asp Lys Asn Lys Leu Val Arg Phe Arg Ala Glu Gly 
145                 150                 155                 160 


Lys Ile Pro Ser Asn Lys Asn Glu Phe Lys Lys Leu Leu Asp Thr Ala 
                165                 170                 175     


Leu Asp Gly Lys Tyr Lys Asp Glu Lys Lys Glu Leu Ser Glu Ala Trp 
            180                 185                 190         


Gly Asn Ile Leu Ile Ala Ser Glu Asn Val Leu Lys Ser Thr Val Asp 
        195                 200                 205             


Gly His Lys Ser Arg Ser Glu Tyr Leu Ala Asn Ile Lys Glu Asp Ile 
    210                 215                 220                 


Lys Ser Asn Glu Glu Leu Glu Lys Gln Ile Ser Ser Lys Glu Ile Asp 
225                 230                 235                 240 


Gly Phe Tyr Asn Leu Val Gly His Leu Ser Asn Phe Gln Leu Arg Leu 
                245                 250                 255     


Leu Arg Lys Tyr Phe Asn Asp Pro Asn Met Ser Gly Val Ser Tyr Trp 
            260                 265                 270         


Asp Glu Lys Arg Leu Glu Lys Tyr Phe Tyr Gln Trp Val Gln Gly Trp 
        275                 280                 285             


His Thr Lys Gly Gly Thr Asp Glu Ala Glu Lys Lys Asn Ile Ile Leu 
    290                 295                 300                 


Lys Thr Lys Gly Ala Pro Leu Leu Lys Thr Leu Lys Ser Leu Ser Ala 
305                 310                 315                 320 


Asp Leu Thr Ile Pro Pro Tyr Glu Asp Gln Asn Asn Arg Arg Pro Pro 
                325                 330                 335     


Lys Cys Gln Ser Val Leu Leu Ser Asp Glu Lys Leu Thr Met His Tyr 
            340                 345                 350         


Pro Lys Trp Lys Glu Trp Val Gly Gln Leu Val Lys Gln Asn Asp Asn 
        355                 360                 365             


Ala Tyr Leu Asn Glu Asn Val Thr Leu Ala Asn Ala Leu His Arg Ile 
    370                 375                 380                 


Val Glu Arg Ser Arg Ser Ile Asp Pro Tyr Gln Leu Arg Leu Leu Ile 
385                 390                 395                 400 


Ser Ile Thr Asp Ala Glu Lys Arg Asn Asp Leu Ala Gly Tyr Lys Arg 
                405                 410                 415     


Leu Lys Leu Ser Leu Gly Ser Glu Val Asp Glu Phe Leu Leu Leu Val 
            420                 425                 430         


Lys Asn Ile Val Asp Glu Thr Lys Glu Ala Arg Glu Gly Leu Trp Phe 
        435                 440                 445             


Glu Thr Glu Asn Lys Leu Phe Phe Lys Cys Gly Lys Thr Pro Pro Arg 
    450                 455                 460                 


Lys Glu Lys Leu Lys Ser Thr Leu Leu Ser Ala Val Leu Gly Lys Asn 
465                 470                 475                 480 


Leu Ser Asp Asp Glu Gln Ser Ser Phe Ile Glu Glu Phe Trp Lys Ser 
                485                 490                 495     


Gly Thr Pro Lys Ile Glu Arg Arg Asn Val Arg Gly Trp Cys Arg Leu 
            500                 505                 510         


Ala Ser Gln Val Gln Lys Thr Tyr Gly Val Tyr Leu Lys Glu Tyr Gly 
        515                 520                 525             


Leu Gln Gln Leu His Lys Leu Glu Ala Gly Lys Lys Leu Asp Asp Lys 
    530                 535                 540                 


Pro Leu Ala Leu Leu Tyr Lys Asn Ser Gly Leu Ile Ala Ser Lys Ile 
545                 550                 555                 560 


Gly Glu Ala Leu Asn Ile Glu Pro Asp Glu Val Ser Arg Phe Ala Ser 
                565                 570                 575     


Pro His Ser Leu Ala Gln Ile Phe Asn Ile Ile Glu Gly Asp Val Ala 
            580                 585                 590         


Gly Phe Asn Lys Thr Cys Arg Ala Cys Thr Tyr Glu Asn Ile Trp Arg 
        595                 600                 605             


Met Gln Glu Glu Lys Val Glu Ser Leu Leu Thr Asn Gln Leu Leu Ser 
    610                 615                 620                 


Glu Ile His Gly Glu Arg Lys Val Pro Leu Lys Ser Ala Met Cys Thr 
625                 630                 635                 640 


Arg Leu Ser Ala Asp Ser Thr Arg Pro Phe Asp Gly Gln Met Ala Ser 
                645                 650                 655     


Ile Ile Glu His Ile Ala Arg Lys Ile Ala Gln His Lys Ile Ala Gln 
            660                 665                 670         


Ile Asn Asp Val Pro Lys Glu Phe Ser Ile Asp Ile Pro Ile Ile Ile 
        675                 680                 685             


Glu Ser Asn Gln Phe Ser Phe Thr Ala Glu Leu Glu Glu Ile Lys Arg 
    690                 695                 700                 


Gly Arg Gly Ser Ala Lys Ala Lys Lys Ala Lys Glu Leu Gly Glu Lys 
705                 710                 715                 720 


Ser Lys Ala Gly Trp Val Ser Lys Thr Glu Arg Ile Lys Thr Ser Ser 
                725                 730                 735     


Glu Gly Ile Cys Pro Tyr Thr Gly Ala Pro Leu Gly Gly Ser Gly Glu 
            740                 745                 750         


Ile Asp His Ile Ile Pro Arg Ser Leu Thr Gly Arg Thr Lys Lys Thr 
        755                 760                 765             


Val Phe Asn Ser Glu Ala Asn Leu Ile Tyr Cys Ser Ser Lys Gly Asn 
    770                 775                 780                 


His Asp Lys Gly Asn Arg Val Tyr Val Ile Glu Gln Leu Asn Asp Lys 
785                 790                 795                 800 


Tyr Leu Lys Lys Gln Phe Ser Thr Ser Asp Val Asn Leu Ile Lys Lys 
                805                 810                 815     


Lys Ile Lys Thr Thr Ile Gln Arg Phe Thr Glu Gly Gly Glu Lys Leu 
            820                 825                 830         


Arg Ser Phe Ser Glu Leu Ser Arg Glu Asp Gln Lys Ala Phe Arg His 
        835                 840                 845             


Ala Leu Phe Val Pro Glu Leu Lys Ser Glu Val Thr Ser Leu Leu Ala 
    850                 855                 860                 


Val Lys Asn Ile Thr Arg Val Asn Gly Thr Gln Ala Trp Leu Ala Lys 
865                 870                 875                 880 


Lys Ile Ala Ser Leu Leu Ala Glu His Leu Asp Lys Gln Gly Arg Asp 
                885                 890                 895     


Tyr Thr Leu Ser Ala His Gln Ile Asp Pro Trp Ser Val Ser Lys Gln 
            900                 905                 910         


Arg Lys Met Leu Ala Ser Ala Glu Pro Ile Trp Ala Lys Lys Asp Pro 
        915                 920                 925             


Gln Pro Ala Ala Ser His Val Val Asp Ala Val Cys Thr Phe Leu Glu 
    930                 935                 940                 


Ala Leu Glu Gln Pro His Thr Ala Ser Arg Leu Lys Thr Ile Ser Ser 
945                 950                 955                 960 


Thr Ser Phe Glu Lys Thr Gly Trp Arg Ser Ala Leu Ile Pro Asp Leu 
                965                 970                 975     


Ile Lys Val Asp Ala Leu Asp Arg Arg Pro Lys Tyr Arg Arg Tyr Asn 
            980                 985                 990         


Ile Gly Ser Thr Ser Leu Phe Lys  Asp Gly Ile Tyr Ala  Glu Arg Phe 
        995                 1000                 1005             


Leu Pro  Ile Leu Ile Asp Glu  Asn Gly Leu Met Ala  Gly Tyr Asp 
    1010                 1015                 1020             


Ile Asp  Asn Ser Leu Lys Ala  Lys Gly Ala Asp Val  Val Phe Glu 
    1025                 1030                 1035             


Ser Leu  Ser Pro Phe Leu Leu  Phe Lys Gly Glu Glu  Val Gly Ala 
    1040                 1045                 1050             


Gln Ser  Leu Ser Asp Trp Gln  Glu Arg Ile Asp Gly  Arg Tyr Leu 
    1055                 1060                 1065             


Tyr Met  Ser Ile Asp Lys Val  Lys Ala Phe Asp Tyr  Leu Gln Glu 
    1070                 1075                 1080             


Lys Val  Gly Glu Lys Asp Ile  Ala Ala Glu Leu Leu  Asn Ser Ile 
    1085                 1090                 1095             


His Phe  Thr Gln Arg Lys Thr  Glu Leu Arg Ala Lys  Phe Ser Asp 
    1100                 1105                 1110             


Asp Ser  Gly Lys Lys Met Lys  Thr Leu Asp Ala Ile  Arg Lys Ser 
    1115                 1120                 1125             


Leu Lys  Leu Thr Val Thr Val  Asn Glu Ile Gly Lys  Arg Lys Glu 
    1130                 1135                 1140             


Lys Cys  Gly Phe Ser Gly Thr  Ile Gly Ile Pro Ala  Lys Ser Ala 
    1145                 1150                 1155             


Trp Glu  Asn Leu Leu Asp Glu  Pro Leu Leu Glu Thr  Tyr Trp Gly 
    1160                 1165                 1170             


Thr Lys  Met Pro Pro Gln Glu  Ile Trp Glu Lys Val  Tyr Arg Lys 
    1175                 1180                 1185             


His Phe  Pro Arg Asn Ile Pro  Asn Gln Ala His Arg  Lys Val Arg 
    1190                 1195                 1200             


Lys Asp  Phe Ser Leu Pro Val  Val Asp Ser Val Ser  Gly Gly Phe 
    1205                 1210                 1215             


Arg Val  Lys Arg Lys Thr Pro  Asn Gly Tyr Asn Tyr  Gln Leu Leu 
    1220                 1225                 1230             


Ala Ile  Asp Gly Tyr Ser Ala  Val Gly Phe Lys Lys  Glu Gly Asp 
    1235                 1240                 1245             


Asn Val  Asp Phe Lys Ser Pro  Ala Leu Val Pro Gln  Ile Ala Glu 
    1250                 1255                 1260             


Ser Lys  Ser Val Thr Pro Ile  Ser Ser Glu Leu Val  His Leu Asp 
    1265                 1270                 1275             


Lys Asn  Glu Ile Val Tyr Phe  Asp Glu Trp Arg Lys  Ile Asp Ile 
    1280                 1285                 1290             


Ser Asp  Ser Asp Leu Lys Gln  Phe Val Ser Ser Leu  Glu Leu Ala 
    1295                 1300                 1305             


Pro Gly  Ser Gln Asn Arg Phe  Tyr Ile Arg Phe Thr  Val Asp Glu 
    1310                 1315                 1320             


Asp Gln  Phe Glu Arg His Phe  Lys Ser Ala Leu Arg  Val Asn Gly 
    1325                 1330                 1335             


Ile Gln  Asp Leu Asp Thr Val  Asn Lys Thr Phe Asp  Trp Asn Arg 
    1340                 1345                 1350             


Glu Ile  Pro Ser Leu Leu Ile  Pro Pro Arg Ser Asn  Leu Phe Leu 
    1355                 1360                 1365             


Leu Glu  Thr Gly Gln Lys Ile  Thr Phe Glu Tyr Ile  Ala Asn Gly 
    1370                 1375                 1380             


Ala Asn  Ala Glu Val Lys Lys  Ala Tyr Ser Leu Arg  Arg Ala 
    1385                 1390                 1395         


<210> 240
<211> 1186
<212> PRT
<213> Gardnerella vaginalis


<220>
<223> Gardnerella vaginalis 1500E

<400> 240
Met Glu Gly Asn Ile Ser Tyr Ala Ile Gly Ile Asp Val Gly Leu Asn 
1               5                   10                  15      


Ser Val Gly Leu Ala Ala Ile Arg Leu Asp Asn Asn Gly Glu Pro Ile 
            20                  25                  30          


Arg Ile Leu Lys Ala Met Ser Val Ile His Asp Ala Gly Ile Asp Pro 
        35                  40                  45              


Asn Gly Ala Lys Glu Ser Asp Thr Arg Lys Ala Ile Ser Gly Val Ala 
    50                  55                  60                  


Arg Arg Val Arg Arg Leu Tyr Arg Gln Arg Arg Arg Arg Leu Gln Lys 
65                  70                  75                  80  


Leu Asp Phe Leu Leu His Ser Leu Gly Phe Pro Val Val Glu Asn Lys 
                85                  90                  95      


Asp Leu Asp Phe Ser Asp Ser Phe Ile Pro Trp Ile Phe Arg Ala Lys 
            100                 105                 110         


Leu Ala Asp Glu Tyr Ile Ala Asp Glu Lys Gln Arg Lys Gln Met Leu 
        115                 120                 125             


Ser Val Ala Ile Arg His Ile Ala Arg His Arg Gly Trp Arg Asn Pro 
    130                 135                 140                 


Tyr Gln Ser Ile Lys Ser Met Thr Gln Glu Thr Glu Tyr Ser Glu Phe 
145                 150                 155                 160 


Tyr Asn Glu Leu Leu Lys Asn Ile Glu Lys Phe Ala Pro Gly Val Gly 
                165                 170                 175     


Cys Glu Gly Ser Thr Pro Ala Gln Leu Val Arg Asp Tyr Leu Leu Leu 
            180                 185                 190         


Gln Gln Gly Lys Ala Ser Arg Arg Leu Arg Ile Thr Thr Asp Glu Lys 
        195                 200                 205             


Arg Lys Asn His Pro Asn Ser Leu Asn Pro Ile Leu Pro Arg Lys Leu 
    210                 215                 220                 


Met Gln Ser Asp Asn Met Leu Glu Ile Leu Asn Ile Phe Asn Val Gln 
225                 230                 235                 240 


His Ile Asp Asp Lys Tyr Val Arg Glu Gln Ile Ile Asn Ala Val Phe 
                245                 250                 255     


Tyr Ala Lys Ser Pro Arg Gly Ser Ala Glu Asn Arg Val Gly Lys Asp 
            260                 265                 270         


Ala Ile Thr Gly Lys Gly Lys Arg Ala Leu Lys Ala Ser Leu Ala Phe 
        275                 280                 285             


Gln Lys Tyr Arg Ile Ile Ser Thr Ile Ser Asn Leu Arg Ile Arg Glu 
    290                 295                 300                 


Asn Ser Lys Glu Arg Cys Leu Thr Ile Glu Glu Lys Gln Ser Val Tyr 
305                 310                 315                 320 


Lys Leu Leu Thr Thr Ser Thr Asp Glu Ser Ser Lys Glu Lys Ser Ala 
                325                 330                 335     


Glu Ala Pro Leu Tyr Thr Trp Ile Asp Val Ala Asp Cys Leu Gly Ile 
            340                 345                 350         


Glu Arg Tyr Lys Leu Arg Gly Val Gly Ser Gln Ile Gly Asp Gly Glu 
        355                 360                 365             


Ser Val Gly Asn Arg Pro Pro Met Leu Asn Ser Glu Leu Ala Ile Ile 
    370                 375                 380                 


Tyr Ala Asn Asn Lys Ser Leu Gly Lys Ser Leu Leu Thr Trp Trp Leu 
385                 390                 395                 400 


Asp Ala Asn Arg Thr Gln Glu Asp Lys Glu Ala Leu Ile Glu Ile Leu 
                405                 410                 415     


Ser Asn Thr Val Asp Ile Glu Ala Ile His Asp Asn Pro Glu Tyr Gln 
            420                 425                 430         


Asp Lys Tyr Gly Ser Ala Ile Ala Phe Ile Asp Ser Met Asp Glu Thr 
        435                 440                 445             


Glu Ile Ala Ala Leu Glu Asn Ile Ser Leu Pro Asp Gly Arg Ala Ala 
    450                 455                 460                 


Tyr Ser Leu Glu Thr Leu Asp Lys Leu Asn Lys Gln Met Leu Glu Thr 
465                 470                 475                 480 


Asp Asp Asp Leu Phe Glu Ala Arg Lys Lys Leu Phe Asn Leu Pro Asn 
                485                 490                 495     


Asn Trp Arg Pro Ser Glu Ala Pro Ile Ala Glu Pro Thr Gly Asn Pro 
            500                 505                 510         


Ser Val Asp Arg Val Leu Lys Ile Val His Arg Phe Leu Ile Ser Ala 
        515                 520                 525             


Lys Asn Arg Trp Gly Asn Pro Glu Arg Ile Asn Ile Glu His Val Arg 
    530                 535                 540                 


Ser Gly Phe Lys Ser Lys Lys Met Ala Asn Ser Tyr Lys Glu Leu Leu 
545                 550                 555                 560 


Asp Lys Arg Thr Lys Gly Lys Glu Asn Leu Lys Ala Met Met Arg Asn 
                565                 570                 575     


Ser Leu His Leu Gly Met Ser Asp Ser Ile Ser Asp Ala Asp Ile Arg 
            580                 585                 590         


Arg Tyr Glu Ala Val Gln Arg Gln Asn Gly Gln Cys Leu Tyr Cys Gly 
        595                 600                 605             


Ser Glu Ile Thr Tyr His Thr Cys Glu Leu Asp His Ile Val Pro Arg 
    610                 615                 620                 


Lys Gly Pro Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Thr Cys 
625                 630                 635                 640 


Ser Leu Cys Asn Ala Gln Lys Cys Asn Thr Pro Phe Ser Thr Trp Cys 
                645                 650                 655     


Glu Gln Ser Thr Tyr Cys Lys Asn His Asp Ile Ser Val Asp Ser Ala 
            660                 665                 670         


Ile Asn Arg Val Arg Ala Phe Ile Phe Pro Pro Asn Ser Tyr Asp Lys 
        675                 680                 685             


Arg Gly Ala Asn Gln Phe Lys Lys Glu Val Ile Ala Arg Leu Lys Gln 
    690                 695                 700                 


Lys Val Gly Asp Glu Ala Phe Asp Asn Arg Ser Ile Glu Ser Val Ala 
705                 710                 715                 720 


Trp Met Ala Asn Glu Leu His Arg Arg Ile Asp Trp Tyr Tyr Asn Ser 
                725                 730                 735     


Gln Asn Tyr Gln Thr Asn Asn Gly Ile Ser Asp Ile Thr Asn Lys Ala 
            740                 745                 750         


Gln Thr Asn Val Gly Val Tyr Ala Gly Ser Leu Thr Ala Ile Ala Arg 
        755                 760                 765             


Arg Met Ser Gly Ile Asp Gly Lys Leu Glu Phe Phe Asp Gly Arg Arg 
    770                 775                 780                 


Lys Thr Arg Phe Asp Arg Arg His His Ala Val Asp Ala Ser Val Ile 
785                 790                 795                 800 


Ala Met Met Thr Pro Gly Ile Ala Gln Ile Leu Ala Ile Lys Cys Asn 
                805                 810                 815     


Leu Arg Glu Thr Gln Leu Leu Gln Gly Asn Lys Val Val Pro Gly Gly 
            820                 825                 830         


Ile Asp Trp Lys Glu Tyr Pro Thr Ala Asn Asp Gln Gly Tyr Gln Gln 
        835                 840                 845             


Tyr Ala Asn Trp Ser Val Arg Met Asn Ala Leu Leu Lys Leu Leu Asn 
    850                 855                 860                 


Glu Glu Met Arg Ala Asp Arg Ile Ala Val Val Asn Ser Ile Arg Leu 
865                 870                 875                 880 


Arg Tyr Asn Asn Ser Ser Val His Gln Tyr Lys Val Asn Ala Leu Leu 
                885                 890                 895     


Lys Leu His Val Gly Asp Glu Ile Asp Ser Gly Thr Ile Arg Arg Ser 
            900                 905                 910         


Ser Thr Pro Ala Leu Tyr Cys Ala Leu Thr Arg Asn Pro Asp Tyr Asp 
        915                 920                 925             


Val Asn Asn Gly Leu Pro Glu Asn Pro Asn Arg Ala Ile Leu Leu His 
    930                 935                 940                 


Asp Lys Lys Leu Asn Ala Asp Asp Ser Ile Thr Phe Phe Lys Ala Gln 
945                 950                 955                 960 


Ala Val Gln Leu Phe Val Arg Glu Gly Ser Ala Glu Ile Gly Ser Ser 
                965                 970                 975     


Thr His His Leu Arg Ile Tyr Glu Tyr Phe Lys Lys Leu Lys Ser Gly 
            980                 985                 990         


Lys Ile Lys Lys Ser Tyr Gly Met  Ile Arg Val Phe Gln  Asn Asp Leu 
        995                 1000                 1005             


His Arg  His Ile His Glu Asp  Leu Phe Ser Cys Asp  Leu Pro Glu 
    1010                 1015                 1020             


Gln Ser  Ile Ser Met Arg Tyr  Ala Asp Thr Glu Val  Ala His Ala 
    1025                 1030                 1035             


Val Gln  Thr Gly Asn Ser Asn  Tyr Leu Gly Tyr Leu  Val Pro Gly 
    1040                 1045                 1050             


Asp Glu  Ile Ile Val Asp Phe  Ser His Val Lys Leu  Ser Gly Asn 
    1055                 1060                 1065             


Ile Gly  Thr Phe Val Glu Phe  Leu Asn Lys Ile Gly  Ala Asn Cys 
    1070                 1075                 1080             


Ala Ala  Tyr Asn His Trp Val  Val Val Gly Thr Asp  Thr Glu Lys 
    1085                 1090                 1095             


Val Leu  Ile Leu Lys Pro Ser  Met Ile Ser Ser Glu  Gly Ile Asp 
    1100                 1105                 1110             


Lys Leu  Tyr Ser Asn Cys Lys  Arg Asn Asn Phe Asp  Tyr Ser Ser 
    1115                 1120                 1125             


Tyr Glu  Lys Ser Ile Asn Glu  Ile Leu Val Gly Lys  Gly Trp Arg 
    1130                 1135                 1140             


Val Ser  Val Asn Val Leu Ala  Lys Tyr Asn Ala Glu  Thr Ile Arg 
    1145                 1150                 1155             


Arg Asn  Ala Leu Gly Glu Val  Arg Trp Thr Ser Arg  Ser His Leu 
    1160                 1165                 1170             


Pro Ile  Ser Trp Ser Trp Asn  Thr Gly Glu Asn Arg  Glu 
    1175                 1180                 1185     


<210> 241
<211> 1186
<212> PRT
<213> Gardnerella vaginalis


<220>
<223> Gardnerella vaginalis 284V

<400> 241
Met Glu Gly Asn Ile Ser Tyr Ala Ile Gly Ile Asp Val Gly Leu Asn 
1               5                   10                  15      


Ser Val Gly Leu Ala Ala Ile Arg Leu Asp Asp Tyr Gly Glu Pro Ile 
            20                  25                  30          


Arg Ile Leu Lys Ala Met Ser Val Ile His Asp Ala Gly Ile Asp Pro 
        35                  40                  45              


Asn Gly Ala Lys Glu Ser Asp Thr Arg Lys Ala Ile Ser Gly Val Ala 
    50                  55                  60                  


Arg Arg Val Arg Arg Leu Tyr Arg Gln Arg Arg Arg Arg Leu Gln Lys 
65                  70                  75                  80  


Leu Asp Phe Leu Leu Gln Ser Leu Gly Trp Pro Val Val Glu Asn Lys 
                85                  90                  95      


Asp Leu Asp Phe Ser Asp Ser Phe Ile Pro Trp Ile Phe Arg Ala Lys 
            100                 105                 110         


Leu Ala Asp Glu Tyr Ile Ala Asp Glu Glu Gln Arg Lys Gln Met Leu 
        115                 120                 125             


Ser Val Ala Ile Arg His Ile Ala Arg His Arg Gly Trp Arg Asn Pro 
    130                 135                 140                 


Tyr Gln Ser Ile Lys Ser Met Met Gln Glu Thr Glu Tyr Ser Glu Phe 
145                 150                 155                 160 


Tyr Asn Glu Leu Leu Lys Asn Ile Glu Lys Leu Ala Pro Gly Val Gly 
                165                 170                 175     


Cys Glu Gly Ser Thr Pro Ala Gln Leu Val Arg Asp Tyr Leu Leu Ser 
            180                 185                 190         


Gln Gln Gly Lys Ala Ser Arg Arg Leu Arg Ile Thr Thr Gly Gly Arg 
        195                 200                 205             


Arg Lys Asn His Pro His Ser Leu Asp Pro Val Leu Pro Arg Lys Leu 
    210                 215                 220                 


Met Gln Ser Asp Asn Met Leu Glu Ile Leu Asn Ile Phe Asn Val Gln 
225                 230                 235                 240 


His Ile Asp Asp Lys Tyr Val Arg Glu Gln Ile Ile Asn Ala Val Phe 
                245                 250                 255     


Tyr Ala Glu Ser Pro Arg Gly Ser Ala Glu Asn Arg Val Gly Lys Asp 
            260                 265                 270         


Ala Ile Thr Gly Lys Gly Lys Arg Ala Leu Lys Ala Ser Leu Ala Phe 
        275                 280                 285             


Gln Lys Tyr Arg Ile Ile Ser Thr Ile Ser Asn Leu Arg Ile Arg Glu 
    290                 295                 300                 


Asn Ser Lys Glu Arg Cys Leu Thr Ile Glu Glu Lys Gln Asn Val Tyr 
305                 310                 315                 320 


Lys Leu Leu Thr Thr Ser Ile Asp Lys Ser Ser Lys Arg Lys Ser Ala 
                325                 330                 335     


Glu Ala Pro Leu Tyr Thr Trp Ile Asp Val Ala Asp Cys Leu Gly Ile 
            340                 345                 350         


Glu Arg Tyr Lys Leu Arg Gly Val Gly Ser Gln Ile Gly Asp Gly Glu 
        355                 360                 365             


Ser Val Gly Asn Arg Pro Pro Met Leu Asn Ser Glu Leu Ala Ile Leu 
    370                 375                 380                 


Tyr Ala Asn Asn Lys Ser Leu Gly Gln Ser Leu Ile Thr Trp Trp Leu 
385                 390                 395                 400 


Ala Ser Asn Arg Thr Gln Glu Asp Lys Glu Ala Leu Ile Glu Ile Leu 
                405                 410                 415     


Ser Asn Thr Val Asp Ile Glu Ala Ile His Asp Asn Pro Glu Tyr Gln 
            420                 425                 430         


Asp Lys Tyr Gly Ser Ala Ile Ala Phe Ile Asp Ser Met Asn Glu Thr 
        435                 440                 445             


Glu Ile Ala Ala Leu Glu Asn Ile Ser Leu Pro Asp Gly Arg Ala Ala 
    450                 455                 460                 


Tyr Ser Leu Glu Thr Leu Asp Glu Leu Asn Lys Gln Met Leu Glu Thr 
465                 470                 475                 480 


Asp Asp Asp Leu Phe Glu Ala Arg Lys Lys Leu Phe Asn Leu Pro Asn 
                485                 490                 495     


Asn Trp Arg Pro Ala Glu Ala Pro Ile Ala Glu Pro Thr Gly Asn Pro 
            500                 505                 510         


Ser Val Asp Arg Val Leu Lys Ile Val His Arg Phe Leu Ile Ser Ala 
        515                 520                 525             


Lys Asn Arg Trp Gly Asn Pro Glu Arg Ile Asn Ile Glu His Val Arg 
    530                 535                 540                 


Ser Gly Phe Gln Ser Lys Lys Met Ala Asn Ser Tyr Lys Glu Leu Leu 
545                 550                 555                 560 


Asp Lys Arg Thr Glu Gly Lys Glu Asn Leu Lys Ala Met Met Arg Asn 
                565                 570                 575     


Ser Leu His Leu Gly Thr Ser Asp Ser Ile Ser Asp Ala Asp Ile Arg 
            580                 585                 590         


Arg Tyr Glu Ala Val Gln Arg Gln Asn Gly Gln Cys Leu Tyr Cys Gly 
        595                 600                 605             


Ser Glu Ile Thr Tyr His Thr Cys Glu Leu Asp His Ile Val Pro Arg 
    610                 615                 620                 


Lys Gly Pro Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Thr Cys 
625                 630                 635                 640 


Ser Ser Cys Asn Ala Gln Lys Cys Asn Thr Pro Phe Ala Thr Trp Cys 
                645                 650                 655     


Glu Gln Ser Thr Tyr Cys Lys Asn His Asp Ile Ser Ala Asp Ser Ala 
            660                 665                 670         


Ile Asn Arg Val Arg Ala Phe Ile Phe Pro Pro Asn Ser Tyr Asp Lys 
        675                 680                 685             


Arg Gly Ala Asn Gln Phe Lys Lys Glu Val Ile Ala Arg Leu Lys Gln 
    690                 695                 700                 


Lys Val Gly Asp Glu Ala Phe Asp Asn Arg Ser Ile Glu Ser Val Ala 
705                 710                 715                 720 


Trp Met Ala Asn Glu Leu His Arg Arg Ile Asp Trp Tyr Tyr Asn Ser 
                725                 730                 735     


Gln Asn Tyr Gln Thr Asn Asn Gly Ile Ser Asp Ile Ser Asn Lys Ala 
            740                 745                 750         


Gln Thr Asn Val Gly Val Tyr Ala Gly Ser Leu Thr Ala Ile Ala Arg 
        755                 760                 765             


Arg Met Ser Gly Ile Asp Gly Lys Leu Glu Phe Phe Asp Gly Arg Arg 
    770                 775                 780                 


Lys Thr Arg Phe Asp Arg Arg His His Ala Val Asp Ala Ser Val Ile 
785                 790                 795                 800 


Ala Met Met Thr Pro Gly Ile Ala Gln Ile Leu Ala Ile Lys Cys Asn 
                805                 810                 815     


Leu Arg Glu Thr Gln Leu Leu Gln Gly Asn Lys Val Val Pro Gly Gly 
            820                 825                 830         


Ile Asp Trp Lys Glu Tyr Pro Thr Ala Asn Asp Gln Gly Tyr Gln Gln 
        835                 840                 845             


Tyr Ala Asn Trp Ser Val Arg Met Asn Ala Leu Leu Lys Leu Leu Asn 
    850                 855                 860                 


Glu Glu Met Arg Ala Asp Arg Ile Ala Val Val Asn Ser Ile Arg Leu 
865                 870                 875                 880 


Arg Tyr Ser Asn Ser Ser Val His Gln Tyr Glu Val Asn Ala Leu Leu 
                885                 890                 895     


Lys Leu His Val Gly Asp Glu Ile Asp Ser Glu Thr Ile Arg Arg Ser 
            900                 905                 910         


Ser Thr Pro Ala Leu Tyr Cys Ala Leu Thr Arg Asn Pro Asp Tyr Asp 
        915                 920                 925             


Val Asn Asn Gly Phe Pro Glu Asn Pro Gly Arg Thr Ile Leu Leu His 
    930                 935                 940                 


Asn Lys Lys Leu Asn Ala Asp Asp Ser Ile Thr Phe Phe Lys Ala Gln 
945                 950                 955                 960 


Ala Val Gln Leu Phe Val Arg Glu Gly Ser Ala Lys Ile Gly Asn Ser 
                965                 970                 975     


Ile His His Leu Arg Ile Tyr Glu Tyr Phe Glu Lys Leu Lys Ser Gly 
            980                 985                 990         


Lys Ile Lys Lys Ser Tyr Gly Met  Ile Arg Val Phe Gln  Asn Asp Leu 
        995                 1000                 1005             


His Arg  His Ile His Glu Asp  Leu Phe Ser Cys Asp  Leu Pro Glu 
    1010                 1015                 1020             


Gln Ser  Ile Ser Met Arg Tyr  Ala Asp Thr Lys Val  Ala His Ala 
    1025                 1030                 1035             


Val Gln  Thr Gly Asn Ala Asn  Tyr Leu Gly Tyr Leu  Val Pro Gly 
    1040                 1045                 1050             


Asp Glu  Ile Ile Val Asp Phe  Ser His Ile Thr Leu  Ser Glu Asn 
    1055                 1060                 1065             


Ile Gly  Lys Phe Val Glu Phe  Leu Asn Lys Ile Gly  Ala Asp Cys 
    1070                 1075                 1080             


Thr Ala  Tyr Arg His Trp Val  Val Val Gly Thr Asp  Thr Glu Lys 
    1085                 1090                 1095             


Val Leu  Ile Leu Lys Pro Ser  Met Ile Ser Ser Glu  Gly Ile Asp 
    1100                 1105                 1110             


Lys Leu  Tyr Ser Asn Cys Glu  Arg Asn Asn Phe Asp  Tyr Ser Ser 
    1115                 1120                 1125             


Tyr Glu  Lys Ser Ile Asn Glu  Ile Leu Ala Gly Lys  Gly Trp Arg 
    1130                 1135                 1140             


Val Ser  Val Asn Val Leu Ala  Gln Tyr Lys Ala Ala  Thr Ile Arg 
    1145                 1150                 1155             


Arg Asn  Ala Leu Gly Glu Val  Arg Trp Ala Ser Arg  Ser His Leu 
    1160                 1165                 1170             


Pro Ile  Ser Trp Ser Trp Asp  Thr Gly Glu Asn Arg  Glu 
    1175                 1180                 1185     


<210> 242
<211> 1186
<212> PRT
<213> Gardnerella vaginalis


<220>
<223> Gardnerella vaginalis 5-1

<400> 242
Met Glu Gly Asn Ile Ser Tyr Ala Ile Gly Ile Asp Val Gly Leu Asn 
1               5                   10                  15      


Ser Val Gly Leu Ala Ala Ile Arg Leu Asp Asn Asn Gly Glu Pro Ile 
            20                  25                  30          


Arg Ile Leu Lys Ala Met Ser Val Ile His Asp Ala Gly Ile Asp Pro 
        35                  40                  45              


Asn Gly Ala Lys Glu Ser Asp Thr Arg Lys Ala Ile Ser Gly Val Ala 
    50                  55                  60                  


Arg Arg Val Arg Arg Leu Tyr Arg Gln Arg Arg Arg Arg Leu Gln Lys 
65                  70                  75                  80  


Leu Asp Phe Leu Leu His Ser Leu Gly Phe Pro Val Val Glu Asn Lys 
                85                  90                  95      


Asp Leu Asp Phe Ser Asp Ser Phe Thr Pro Trp Ile Phe Arg Ala Lys 
            100                 105                 110         


Leu Ala Asp Glu Tyr Ile Ala Asp Glu Lys Gln Arg Lys Gln Met Leu 
        115                 120                 125             


Ser Val Ala Ile Arg His Ile Ala Arg His Arg Gly Trp Arg Asn Pro 
    130                 135                 140                 


Tyr Gln Ser Ile Lys Ser Met Thr Gln Glu Thr Glu Tyr Ser Glu Phe 
145                 150                 155                 160 


Tyr Asn Glu Leu Leu Lys Asn Ile Glu Lys Phe Ala Pro Gly Val Ser 
                165                 170                 175     


Cys Glu Gly Ser Thr Pro Ala Gln Leu Val Arg Asp Tyr Leu Leu Ser 
            180                 185                 190         


Gln Gln Gly Lys Ala Ser Arg Arg Leu Arg Ile Thr Thr Asp Asp Arg 
        195                 200                 205             


Arg Lys Asn His Pro Asn Ser Leu Asp Pro Val Leu Pro Arg Lys Leu 
    210                 215                 220                 


Met Gln Ser Asp Asn Met Leu Glu Ile Leu Asn Ile Phe Asn Val Gln 
225                 230                 235                 240 


His Ile Asp Asn Lys Tyr Val Arg Glu Gln Ile Ile Asn Ala Val Phe 
                245                 250                 255     


Tyr Ala Lys Ser Pro Arg Gly Ser Ala Glu Asn Arg Val Gly Lys Asp 
            260                 265                 270         


Ala Ile Thr Gly Lys Gly Lys Arg Ala Leu Lys Ala Ser Leu Ala Phe 
        275                 280                 285             


Gln Lys Tyr Arg Ile Ile Ser Thr Ile Ser Asn Leu Arg Ile Arg Glu 
    290                 295                 300                 


Asn Ser Lys Glu Arg Cys Leu Thr Ile Glu Glu Lys Gln Ser Val Tyr 
305                 310                 315                 320 


Lys Leu Leu Thr Thr Ser Thr Asp Glu Tyr Ser Lys Glu Lys Ser Ala 
                325                 330                 335     


Glu Ala Pro Leu Tyr Thr Trp Ile Asp Val Ala Asp Cys Leu Gly Ile 
            340                 345                 350         


Glu Arg Tyr Lys Leu Arg Gly Val Gly Ser Gln Ile Glu Asp Gly Glu 
        355                 360                 365             


Ser Val Gly Asn Arg Pro Pro Met Leu Asn Ser Glu Leu Ala Ile Leu 
    370                 375                 380                 


Tyr Ala Asn Ala Lys Ser Leu Lys Gln Ser Leu Ile Thr Trp Trp Leu 
385                 390                 395                 400 


Ala Ala Asn Arg Thr Gln Glu Asp Lys Glu Ala Phe Ile Glu Ile Leu 
                405                 410                 415     


Ser Asn Thr Val Asp Ile Glu Ala Ile His Asp Asn Pro Glu Tyr Gln 
            420                 425                 430         


Asp Lys Tyr Gly Ser Val Ile Ala Phe Ile Asp Ser Met Asp Glu Thr 
        435                 440                 445             


Glu Ile Ala Ala Leu Glu Asn Ile Ser Leu Pro Asn Gly Arg Ala Ala 
    450                 455                 460                 


Tyr Ser Leu Glu Thr Leu Asp Lys Leu Asn Lys Gln Met Leu Glu Thr 
465                 470                 475                 480 


Asp Asp Asp Leu Phe Glu Ala Arg Lys Lys Leu Phe Asn Leu Pro Asn 
                485                 490                 495     


Asn Trp Arg Pro Ser Glu Ala Pro Ile Ala Glu Pro Thr Gly Asn Pro 
            500                 505                 510         


Ser Val Asp Arg Val Leu Lys Ile Val His Arg Phe Leu Ile Ser Ala 
        515                 520                 525             


Lys Asn Arg Trp Gly Asn Pro Glu Arg Ile Asn Ile Glu His Val Arg 
    530                 535                 540                 


Ser Gly Phe Gln Ser Lys Lys Met Ala Asn Ser Tyr Lys Lys Leu Leu 
545                 550                 555                 560 


Asp Lys Arg Thr Glu Gly Lys Glu Asn Leu Lys Ala Met Met Arg Asn 
                565                 570                 575     


Ser Leu His Leu Gly Thr Ser Asp Ser Ile Ser Asp Ala Asp Ile Arg 
            580                 585                 590         


Arg Tyr Glu Ala Val Gln Arg Gln Asn Gly Gln Cys Leu Tyr Cys Gly 
        595                 600                 605             


Ser Glu Ile Thr Tyr His Thr Cys Glu Leu Asp His Ile Val Pro Arg 
    610                 615                 620                 


Lys Gly Pro Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Thr Cys 
625                 630                 635                 640 


Ser Ser Cys Asn Ala Gln Lys Cys Asn Thr Pro Phe Ala Thr Trp Cys 
                645                 650                 655     


Glu Glu Ser Thr Tyr Cys Lys Asn His Asp Ile Ser Val Asp Ser Ala 
            660                 665                 670         


Ile Asn Arg Val Arg Ala Phe Ile Phe Pro Pro Asn Ser Tyr Asp Lys 
        675                 680                 685             


Arg Gly Ala Ser Gln Phe Lys Lys Glu Val Ile Ala Arg Leu Lys Gln 
    690                 695                 700                 


Lys Val Gly Asp Glu Ala Phe Asp Asn Arg Ser Ile Glu Ser Val Ala 
705                 710                 715                 720 


Trp Met Ala Asn Glu Leu His Arg Arg Ile Asp Trp Tyr Tyr Asn Ser 
                725                 730                 735     


Gln Asn Tyr Gln Thr Asn Asn Gly Ile Ser Asp Ile Thr Asn Lys Ala 
            740                 745                 750         


Gln Thr Asn Val Gly Val Tyr Ala Gly Ser Leu Thr Ala Ile Ala Arg 
        755                 760                 765             


Arg Met Ser Gly Ile Asp Gly Lys Leu Glu Phe Phe Asp Gly Arg Arg 
    770                 775                 780                 


Lys Thr Arg Phe Asp Arg Arg His His Ala Val Asp Ala Ser Val Ile 
785                 790                 795                 800 


Ala Met Met Thr Pro Gly Ile Ala Gln Ile Leu Ala Ile Lys Cys Asn 
                805                 810                 815     


Leu Arg Glu Thr Gln Leu Leu Gln Gly Asn Lys Val Val Pro Gly Gly 
            820                 825                 830         


Ile Asp Trp Lys Glu Tyr Pro Thr Ala Asn Asp Gln Gly Tyr Gln Gln 
        835                 840                 845             


Tyr Ala Asn Trp Ser Val Arg Met Asn Ala Leu Leu Glu Leu Leu Asn 
    850                 855                 860                 


Glu Glu Met Arg Ala Asp Arg Ile Ala Val Val Asn Ser Ile Arg Leu 
865                 870                 875                 880 


Arg Tyr Ser Asn Ser Ser Val His Lys Asp Asp Val His Ala Leu Leu 
                885                 890                 895     


Lys Leu His Val Gly Asp Glu Ile Asp Ser Glu Thr Ile Arg Arg Ala 
            900                 905                 910         


Ser Thr Pro Ala Leu Tyr Cys Ala Leu Thr Arg Asn Pro Asp Tyr Asp 
        915                 920                 925             


Val Asn Asn Gly Leu Pro Glu Asn Thr Asp Arg Thr Ile Leu Leu His 
    930                 935                 940                 


Asp Lys Lys Leu Asn Ala Asp Asp Ser Ile Thr Phe Phe Lys Ser Lys 
945                 950                 955                 960 


Ala Ala Gln Leu Phe Val Arg Glu Gly Ser Val Glu Ile Gly Asn Ser 
                965                 970                 975     


Ile His His Leu Arg Ile Tyr Glu Tyr Phe Glu Lys Leu Lys Ser Gly 
            980                 985                 990         


Lys Val Lys Lys Ser Tyr Gly Met  Ile Arg Val Phe Gln  Asp Asp Leu 
        995                 1000                 1005             


His Arg  Tyr Ile His Glu Asp  Leu Phe Ser Cys Asp  Leu Pro Glu 
    1010                 1015                 1020             


Gln Ser  Ile Ser Met Arg Tyr  Ala Asp Thr Lys Val  Ala His Ala 
    1025                 1030                 1035             


Val Gln  Thr Gly Asn Ala Asn  Tyr Leu Gly Tyr Leu  Val Pro Gly 
    1040                 1045                 1050             


Asp Glu  Ile Ile Val Asp Phe  Ser His Val Lys Leu  Ser Gly Tyr 
    1055                 1060                 1065             


Ile Gly  Glu Phe Val Glu Phe  Leu Asn Lys Ile Gly  Ala Asn Cys 
    1070                 1075                 1080             


Ala Ala  Tyr Lys His Trp Val  Val Ala Gly Thr Asp  Asp Lys Thr 
    1085                 1090                 1095             


Thr Leu  Ile Leu Lys Pro Ser  Met Ile Ser Ser Glu  Gly Ile Asp 
    1100                 1105                 1110             


Lys Leu  Tyr Ser Asn Cys Glu  Arg Asn Asn Phe Asp  Tyr Ala Ser 
    1115                 1120                 1125             


Tyr Glu  Lys Ser Ile Asp Lys  Ile Leu Val Asp Lys  Gly Trp Arg 
    1130                 1135                 1140             


Val Ser  Val Asn Val Leu Asp  Gln Tyr Lys Ala Ala  Thr Ile Arg 
    1145                 1150                 1155             


Arg Asn  Ala Leu Gly Glu Pro  Arg Trp Ala Ser Arg  Ser His Leu 
    1160                 1165                 1170             


Pro Ile  Ser Trp Ser Trp Asp  Thr Gly Glu Asn Arg  Glu 
    1175                 1180                 1185     


<210> 243
<211> 1392
<212> PRT
<213> Gemella haemolysans


<220>
<223> Gemella haemolysans ATCC 10379

<400> 243
Met Ala Asn Lys Thr Trp Tyr Leu Gly Leu Asp Ile Gly Ser Ala Ser 
1               5                   10                  15      


Val Gly Trp Ala Ala Thr Asp Thr Gly Tyr Lys Ile Ile Arg Lys Asn 
            20                  25                  30          


Lys Lys Arg Leu Trp Gly Val Arg Leu Phe Glu Glu Ala Lys Thr Ala 
        35                  40                  45              


Glu Asp Arg Arg Gly Tyr Arg Ser Ser Arg Arg Arg Leu Ala Arg Arg 
    50                  55                  60                  


Lys Trp Arg Leu Asn Leu Leu Glu Glu Leu Phe Thr Ser Glu Val Lys 
65                  70                  75                  80  


Lys Val Asp Glu Asn Phe Phe Leu Arg Leu Lys Glu Ser Gln Tyr His 
                85                  90                  95      


Tyr Glu Asp Lys Thr His Lys Val Pro Tyr Ala Ile Phe Asn Asp Lys 
            100                 105                 110         


Asp Tyr Thr Asp Lys Asp Tyr Tyr Lys Asp Tyr Pro Thr Ile Tyr His 
        115                 120                 125             


Leu Arg Ser Lys Leu Met Thr Glu Glu Asn Pro Asp Ile Arg Lys Val 
    130                 135                 140                 


Phe Leu Ala Ile His His Ile Ile Lys Asn Arg Gly His Phe Leu Leu 
145                 150                 155                 160 


Gln Gly Gln Ser Phe Lys Asp Gly Asn Leu Asn Asn Leu Ile Lys Glu 
                165                 170                 175     


Leu Leu Glu Leu Asp Ile Leu His Val Gly Phe Glu Val Thr Glu Glu 
            180                 185                 190         


Val Val Asp Lys Ile Ala Asp Ile Ser Leu Glu Lys Lys Thr Ser Lys 
        195                 200                 205             


Asp Lys Leu Asn Asp Ile Lys Glu Leu Tyr Pro Lys Glu Lys Gln Leu 
    210                 215                 220                 


Leu Glu Val Phe Arg Leu Ile Phe Gly Gly Lys Thr Ser Leu Asp Lys 
225                 230                 235                 240 


Leu Phe Ala Ile Asp Glu Tyr Lys Glu Leu Asp Ala Ala Ile Lys Ser 
                245                 250                 255     


Val Ser Phe Lys Glu Lys Ile Tyr Glu Glu Val Arg His Asp Tyr Glu 
            260                 265                 270         


Gln Val Leu Ser Asn Tyr Ile Glu Leu Leu Asp Leu Ala Lys Leu Val 
        275                 280                 285             


Tyr Asp Ser Ile Ile Leu Ser Asp Ile Lys Lys Glu Gly Lys Thr Leu 
    290                 295                 300                 


Ser Glu Ser Lys Val Glu Leu Phe Glu Lys His Arg Asp Asp Leu Leu 
305                 310                 315                 320 


Lys Leu Lys Asn Leu Val Lys Asn Asp Ser Lys Leu Ser Glu Asp Lys 
                325                 330                 335     


Lys Val Glu Leu Tyr Ala Leu Ile Phe Lys Glu Asp Lys Asp Lys Gly 
            340                 345                 350         


Thr Asn Tyr Val Asn Tyr Ile Arg Lys Ser Glu Glu Gly Lys Gly Cys 
        355                 360                 365             


Asn Tyr Glu Asp Phe Lys Lys Phe Leu Val Lys Glu Leu Ala Lys Leu 
    370                 375                 380                 


Glu Glu Ser Ser Val Lys Thr Glu Ile Ile Lys Asp Leu Glu Leu Glu 
385                 390                 395                 400 


Gln Phe Leu Pro Leu Gln Arg Thr Lys Asp Asn Ser Val Val Pro Tyr 
                405                 410                 415     


Gln Ile His Lys Glu Glu Leu Val Lys Ile Leu Asp Asn Ala Ala Arg 
            420                 425                 430         


Tyr His Ser Phe Leu Asn Glu Lys Asp Glu Ser Gly Tyr Asn Val Arg 
        435                 440                 445             


Glu Lys Val Ile Gln Leu Leu Glu Phe Arg Ile Pro Tyr Tyr Val Gly 
    450                 455                 460                 


Pro Leu Asn Ser Ser Lys Lys Ala Lys Glu Gly Gly Phe Ala Trp Ser 
465                 470                 475                 480 


Val Arg Asn Thr Gly Tyr Glu Asn Thr Pro Val Thr Pro Trp Asn Tyr 
                485                 490                 495     


Ser Lys Val Ile Asp Glu Ser Ala Ser Ala Glu Lys Phe Ile Thr Asn 
            500                 505                 510         


Leu Thr Asn Lys Cys Thr Tyr Leu Lys Gly Glu Asp Val Leu Pro Lys 
        515                 520                 525             


Ser Ser Leu Leu Tyr Ser Glu Phe Ala Leu Leu Asn Glu Leu Asn Ala 
    530                 535                 540                 


Leu Lys Tyr Asp Gly Asn Arg Ile Ser Leu Glu Ala Arg Asn Thr Ile 
545                 550                 555                 560 


Ile Glu Lys Leu Phe Lys Gln Gln Gly Lys Lys Val Thr Lys Thr Ser 
                565                 570                 575     


Ile Lys Asn Leu Leu Lys Ala Glu Gly Tyr Ile Asp Gly Lys Gly Glu 
            580                 585                 590         


Ile Thr Gly Ile Asp Ile Thr Val Lys Asn Asp Leu Lys Ser Tyr Arg 
        595                 600                 605             


Asp Phe Lys Lys Ile Leu Gly Asn Lys Phe Asn Ser Glu His Val Glu 
    610                 615                 620                 


Asn Ile Ile Leu Trp Ile Thr Leu Tyr Gly Glu Ser Arg Lys Leu Ile 
625                 630                 635                 640 


Lys Ala Lys Ile Glu Ser Val Tyr Gly Glu Val Tyr Ser Lys Asp Glu 
                645                 650                 655     


Ile Thr Lys Met Ser Arg Leu Val Tyr Lys Asp Trp Gly Arg Phe Ser 
            660                 665                 670         


Arg Lys Leu Leu Thr Glu Leu Val Ser Lys Lys Leu Tyr Asn Glu Glu 
        675                 680                 685             


Thr Gly Glu Cys Leu Asn Ile Ile Gly Ala Met Arg Gln Asn Asn Ile 
    690                 695                 700                 


Leu Phe Met Glu Leu Leu Ala Asp Arg Phe Asp Tyr Ser Lys Gln Ile 
705                 710                 715                 720 


Val Glu Phe Asn Lys Glu Leu Gln Glu Asp Val Thr Glu Ile Ala Pro 
                725                 730                 735     


Glu Ile Leu Asp Asp Leu Tyr Val Ser Pro Ala Val Lys Arg Ser Ile 
            740                 745                 750         


Trp Gln Thr Val Arg Ile Val Glu Glu Leu Lys Lys Ile Ile Gly Cys 
        755                 760                 765             


Ala Pro Ala Lys Ile Phe Val Glu Thr Thr Arg Ser Asn Gln Glu Lys 
    770                 775                 780                 


Lys Lys Pro Thr Asp Ser Arg Lys Lys Gln Leu Glu Leu Ala Tyr Lys 
785                 790                 795                 800 


Ala Val Lys Lys Asp Val Lys Glu Leu Glu Lys Glu Ile Gly Thr Ile 
                805                 810                 815     


Asn Phe Asp Val Leu Asn Asp Arg Leu Ser Ser Val Glu Pro Ser Lys 
            820                 825                 830         


Leu Lys Ala Lys Lys Leu Tyr Leu Tyr Tyr Thr Gln Leu Gly Arg Cys 
        835                 840                 845             


Met Tyr Ser Glu Glu Pro Ile Asn Ile Ser Glu Leu Phe Asp Asn Asn 
    850                 855                 860                 


Lys Tyr Asp Ile Asp His Ile Tyr Pro Gln Ser Lys Ile Lys Asp Asp 
865                 870                 875                 880 


Ser Phe Thr Asn Thr Val Leu Val Lys Arg Glu Ser Asn Ala Ala Lys 
                885                 890                 895     


Thr Asp Arg Tyr Pro Leu Gly Ser Asp Ile Gln Thr Pro Ser Asn Arg 
            900                 905                 910         


Arg Phe Trp Lys Phe Leu Lys Glu Lys Gly Leu Ile Ser Asp Glu Lys 
        915                 920                 925             


Tyr Asn Arg Leu Val Arg Thr Glu Glu Phe Ser Asp Glu Glu Leu Ser 
    930                 935                 940                 


Gly Phe Ile Ala Arg Gln Leu Val Glu Thr Ser Gln Ser Val Lys Ala 
945                 950                 955                 960 


Val Ala Ser Ile Leu Gly Glu Leu Asn Pro Glu Thr Ser Ile Cys Tyr 
                965                 970                 975     


Ser Lys Ala Glu Asn Val Ser Ser Phe Arg Gln Asn Phe Gly Lys Ile 
            980                 985                 990         


Lys Lys Gly Asp Arg Asp Ser Lys  Asn Asn Asp Gln Leu  Ile Lys Val 
        995                 1000                 1005             


Arg Glu  Ile Asn Asp Tyr His  His Ala Lys Asp Ala  Tyr Leu Asn 
    1010                 1015                 1020             


Val Val  Val Gly Asn Val Tyr  Asp Thr Lys Phe Thr  Arg Asn Val 
    1025                 1030                 1035             


Phe Asn  Phe Ile Lys Asp Lys  Lys Asp Gly Arg Lys  Tyr Ser Leu 
    1040                 1045                 1050             


Asn Lys  Val Phe Tyr Glu Asn  Val Ser Asp Ser Lys  Thr Val Ala 
    1055                 1060                 1065             


Trp Glu  Met Asp Lys Thr Ile  His Gln Val Glu Lys  Val Met Asn 
    1070                 1075                 1080             


Asn Asn  Asn Ile Met Val Thr  Arg Arg Thr Ser Glu  Gln Lys Gly 
    1085                 1090                 1095             


Gly Leu  Phe Asp Ala Thr Val  Tyr Lys Ala Lys Val  Ala Ala Lys 
    1100                 1105                 1110             


Ala Lys  Asp Gly Val Tyr Tyr  Pro Leu Lys Thr Ser  Asn Ser Val 
    1115                 1120                 1125             


Val Lys  Asp Val Ala Lys Tyr  Gly Gly Tyr Thr Ser  Ile Gly Ile 
    1130                 1135                 1140             


Ala Tyr  Tyr Ser Ile Phe Glu  Tyr Thr Ile Val Asn  Lys Lys Gly 
    1145                 1150                 1155             


Glu Glu  Lys Ile Thr Arg Ile  Ile Pro Ile Pro Ile  Tyr Ile Ser 
    1160                 1165                 1170             


Gln Asn  Ile Lys Asp Ser Thr  Ala Leu Ile Glu Phe  Gly Lys Ser 
    1175                 1180                 1185             


Gln Ile  Phe Cys Arg Ala Tyr  Glu Lys Ile Lys Asp  Phe Lys Leu 
    1190                 1195                 1200             


Leu Tyr  Arg Lys Leu Cys Ile  Gly Ser Lys Ile Asn  Ile Asn Asn 
    1205                 1210                 1215             


Tyr Gln  Tyr Tyr Ile Gly Gly  Lys Ser Asp Glu Arg  Phe Tyr Tyr 
    1220                 1225                 1230             


Asp Ser  Ala Ile Gln Val Thr  Leu Asp Lys Lys Ser  Glu Lys Tyr 
    1235                 1240                 1245             


Leu Lys  Ile Leu Ser Lys Tyr  Gln Asn Trp Lys Lys  Glu Asn Lys 
    1250                 1255                 1260             


Asp Gly  Glu Leu Trp Glu Asn  Ile Thr Lys Glu Asn  Asn Ile Glu 
    1265                 1270                 1275             


Leu Tyr  Asn Lys Leu Val Glu  Lys Met Asn Ser Glu  Ile Phe Thr 
    1280                 1285                 1290             


Lys Lys  Lys Ser Asn Lys Tyr  Asn Glu Leu Asn Ser  Glu Glu Ile 
    1295                 1300                 1305             


Arg Asn  Asn Phe Ile Lys Ile  Ser Val Glu Glu Gln  Ala Lys Val 
    1310                 1315                 1320             


Leu Leu  Glu Ile Leu Asn Leu  Leu Thr Asn Lys Lys  Ser Ile Phe 
    1325                 1330                 1335             


Asp Leu  Lys Ser Ile Asp Ile  Lys Ala Ala Arg Gly  Lys Ile Ser 
    1340                 1345                 1350             


Phe Asn  Leu Thr Ser Leu Ile  Gln Phe Ser Ile Ile  Glu Gln Ser 
    1355                 1360                 1365             


Ile Thr  Gly Phe Tyr Glu Lys  Glu Ile Thr Ile Ile  Gly Asp Lys 
    1370                 1375                 1380             


Gly Asn  Asp Met Glu Asn Asn  Asn Ser 
    1385                 1390         


<210> 244
<211> 1385
<212> PRT
<213> Gemella morbillorum


<220>
<223> Gemella morbillorum M424

<400> 244
Met Lys Asn Lys Thr Trp Tyr Leu Gly Leu Gly Val Gly Pro Thr Ser 
1               5                   10                  15      


Ile Gly Trp Ala Ala Thr Asp Ser Asn Tyr Lys Leu Leu Arg Lys Asn 
            20                  25                  30          


Lys Lys Arg Leu Trp Gly Val Arg Leu Phe Glu Glu Ala Lys Thr Ala 
        35                  40                  45              


Val Asp Arg Arg Thr Phe Arg Ala Glu Arg Arg Arg Leu Ala Arg Arg 
    50                  55                  60                  


Lys Trp Arg Ile Ser Leu Leu Glu Glu Leu Phe Ala Lys Glu Val Ser 
65                  70                  75                  80  


Lys Asn Asp Pro Asn Phe Phe Leu Arg Leu Lys Glu Ser Lys Tyr His 
                85                  90                  95      


Phe Glu Asp Lys Ser Leu Met Asn Glu Tyr Ile Leu Phe Asn Asp Lys 
            100                 105                 110         


Asp Tyr Thr Asp Lys Asp Tyr Tyr Lys Glu Tyr Pro Thr Ile Tyr His 
        115                 120                 125             


Leu Arg Leu Ser Leu Thr Thr Glu Glu Asn Pro Asp Ile Arg Lys Val 
    130                 135                 140                 


Tyr Leu Ala Val His Ser Met Leu Lys Asn Arg Gly His Phe Leu Leu 
145                 150                 155                 160 


Gln Gly Gln Ser Phe Asn Asp Ser Asn Ile Asp Ser Val Ile Lys Glu 
                165                 170                 175     


Leu Leu Glu Leu Glu Thr Val Lys Ile Asn Phe Glu Val Thr Asp Glu 
            180                 185                 190         


Val Ile His Ser Leu Lys Lys Ile Ala Leu Glu Lys Lys Asn Leu Ser 
        195                 200                 205             


Asp Lys Asn Asn Asp Val Lys Lys Leu Tyr Pro Lys Glu Lys Gln Leu 
    210                 215                 220                 


Gln Glu Ile Phe Lys Leu Val Phe Gly Gly Lys Thr Ser Leu Asp Lys 
225                 230                 235                 240 


Leu Tyr Asp Ile Glu Glu Tyr Lys Glu Leu Asp Asn Ser Val Lys Ser 
                245                 250                 255     


Ile Ser Phe Lys Glu Lys Val Tyr Glu Glu Val Arg Pro Asp Tyr Glu 
            260                 265                 270         


Gln Ile Leu Ser Asn Tyr Ile Glu Leu Leu Asp Leu Ala Lys Leu Val 
        275                 280                 285             


Tyr Asp Ser Ile Val Leu Ala Asp Ile Lys Lys Glu Gly Lys Thr Ile 
    290                 295                 300                 


Ser Glu Ser Lys Val Glu Leu Tyr Asn Lys His Lys Asp Asp Leu Ala 
305                 310                 315                 320 


Asn Leu Lys Lys Leu Val Lys Ile Asp Ser Lys Leu Ser Glu Asp Lys 
                325                 330                 335     


Lys Lys Glu Val Tyr Phe Thr Ile Phe Lys Glu Asp Lys Glu Lys Gly 
            340                 345                 350         


Thr Asn Tyr Val Asn Tyr Thr His Arg Ser Gln Glu Gly Lys Ser Cys 
        355                 360                 365             


Ser Tyr Glu Asp Phe Lys Lys Phe Leu Lys Lys Glu Leu Glu Lys Leu 
    370                 375                 380                 


Glu Asp Ser Pro Thr Lys Thr Thr Ile Leu Glu Glu Leu Asp Leu Glu 
385                 390                 395                 400 


Thr Phe Leu Pro Leu Gln Arg Thr Lys Asp Asn Ser Val Val Pro Tyr 
                405                 410                 415     


Gln Ile His Lys Glu Glu Leu Val Lys Ile Leu Asp Asn Ala Ala Lys 
            420                 425                 430         


Tyr His Ser Phe Leu Ala Glu Lys Asp Asp Ser Gly Tyr Ser Thr Arg 
        435                 440                 445             


Glu Lys Val Val Gln Leu Phe Glu Phe Arg Ile Pro Tyr Tyr Ile Gly 
    450                 455                 460                 


Pro Leu Asn Ala His His Asn Thr Glu Asn Gly Gly Tyr Ser Trp Ala 
465                 470                 475                 480 


Ile Arg Lys Lys Gly Met Glu Ser Val Pro Val Thr Pro Trp Asn Phe 
                485                 490                 495     


Lys Asp Val Ile Asp Glu Ser Ala Ser Ala Glu Ala Phe Val Asn Asn 
            500                 505                 510         


Leu Lys Asn Lys Cys Ala Tyr Leu Ser Gly Glu Asp Val Leu Pro Lys 
        515                 520                 525             


Asn Ser Leu Leu Tyr Ser Glu Tyr Ala Leu Leu Asn Glu Leu Asn Ala 
    530                 535                 540                 


Leu Arg Tyr Glu Gly Asn Arg Ile Ser Val Glu Ala Arg Asp Val Ile 
545                 550                 555                 560 


Val Thr Lys Leu Phe Lys Glu Gln Gly Lys Lys Val Thr Lys Lys Thr 
                565                 570                 575     


Ile Lys Glu Leu Leu Lys Thr Glu Gly Phe Ile Asp Gly Lys Gly Glu 
            580                 585                 590         


Ile Val Gly Ile Asp Asn Ile Val Lys Asn Asp Leu Lys Ser Tyr Arg 
        595                 600                 605             


Asp Phe Lys Lys Ile Leu Ala Asp Lys Phe Asp Lys Glu Arg Val Glu 
    610                 615                 620                 


Asn Ile Ile Leu Trp Ile Thr Leu Tyr Gly Glu Ser Arg Lys Leu Ile 
625                 630                 635                 640 


Lys Glu Lys Ile Thr Lys Val Tyr Gly Asp Phe Tyr Thr Val Asp Glu 
                645                 650                 655     


Ile Glu Lys Met Ser Arg Leu Thr Tyr Lys Asp Trp Gly Ile Leu Ser 
            660                 665                 670         


Arg Lys Leu Leu Thr Glu Leu Val Ser Glu Lys Leu Tyr Asn Glu Glu 
        675                 680                 685             


Thr Gly Glu Cys Leu Asn Ile Ile Gly Ala Met Arg Gln Gly Thr Ile 
    690                 695                 700                 


Leu Phe Met Glu Leu Leu Ala Asp Lys Phe Asp Tyr Met Ser Gln Ile 
705                 710                 715                 720 


Lys Asn His Asn Lys Glu Asn Lys Asp Asp Ile Thr Glu Ile Thr Pro 
                725                 730                 735     


Asp Ile Leu Glu Asn Leu His Ala Ser Pro Ala Val Lys Arg Ser Ile 
            740                 745                 750         


Trp Gln Thr Val Arg Ile Val Glu Glu Leu Lys Thr Ile Ile Gly Cys 
        755                 760                 765             


Val Pro Thr Lys Ile Phe Ile Glu Thr Thr Lys Arg Asn Asn Ala Pro 
    770                 775                 780                 


Tyr Lys Val Pro Thr Leu Asn Arg Asn Asp Leu Val Thr Lys Tyr Lys 
785                 790                 795                 800 


Thr Ile Arg Glu His Glu Ile Phe Glu Leu Glu Lys Glu Leu Lys Asn 
                805                 810                 815     


Thr Leu Asp Phe Thr Leu Asn Lys Asn Arg Leu Ile Asn Glu Glu Pro 
            820                 825                 830         


Ser Lys Leu Lys Ala Thr Lys Leu Tyr Leu Tyr Tyr Thr Gln Leu Gly 
        835                 840                 845             


Arg Cys Met Tyr Thr Gly Lys Lys Ile Asp Leu Gly Glu Leu Phe Asp 
    850                 855                 860                 


Asn Asn Asn Lys Tyr Asp Ile Asp His Ile Tyr Pro Gln Ser Lys Val 
865                 870                 875                 880 


Lys Asp Gly Ser Phe Asn Asn Ile Val Leu Val Thr Lys Ala Ser Asn 
                885                 890                 895     


Asp Met Lys Ala Asp Val Phe Pro Leu Lys Ser Lys Phe Gln Thr Lys 
            900                 905                 910         


Glu Asn Lys Ile Phe Trp Arg Phe Leu Lys Glu Lys Lys Leu Ile Thr 
        915                 920                 925             


Glu Glu Lys Tyr Asn Arg Leu Val Arg Thr Glu Glu Phe Ser Asn Gly 
    930                 935                 940                 


Glu Leu Thr Gly Phe Ile Thr Arg Gln Leu Val Glu Thr Ser Gln Ala 
945                 950                 955                 960 


Ile Lys Val Ile Ser Asn Val Leu Arg Glu Leu Asn Pro Glu Thr Thr 
                965                 970                 975     


Ile Cys Tyr Ser Lys Ala Glu Asn Val Ser Ser Phe Arg Gln Ser Phe 
            980                 985                 990         


Gly Lys Ile Lys Glu Ala Asn Arg  Lys Ala Glu Asn Asn  Glu Lys Leu 
        995                 1000                 1005             


Ile Arg  Val Gln Glu Ile Asn  Asp Tyr Tyr Asn Ala  Lys Asp Ala 
    1010                 1015                 1020             


Tyr Leu  Ser Ile Val Val Gly  Asn Val Tyr Asp Val  Lys Phe Thr 
    1025                 1030                 1035             


Arg Asn  Val His Asn Phe Ile  Lys Asn Asn Lys Asp  Ala Arg Arg 
    1040                 1045                 1050             


Tyr Ser  Leu Asn Gly Leu Phe  Tyr Thr Asp Val Lys  Asn Ala Asn 
    1055                 1060                 1065             


Thr Ile  Ala Trp Glu Met Asp  Lys Thr Val His Val  Val Glu Lys 
    1070                 1075                 1080             


Thr Met  Asn Asn Asn Asn Ile  Leu Ile Thr Arg Arg  Thr Ser Glu 
    1085                 1090                 1095             


Gln Lys  Gly Ala Leu Tyr Asp  Ala Thr Leu Tyr Lys  Ala Lys Val 
    1100                 1105                 1110             


Ala Glu  Lys Ala Lys Glu Gly  Thr Tyr Tyr Pro Leu  Lys Thr Thr 
    1115                 1120                 1125             


Asp Ser  Lys Ile Lys Asp Val  Gly Lys Tyr Gly Gly  Phe Thr Lys 
    1130                 1135                 1140             


Ile Lys  Ile Ala Tyr Tyr Ser  Ile Phe Glu Tyr Thr  Leu Asp Gly 
    1145                 1150                 1155             


Lys Lys  Gly Lys Gln Lys Ile  Thr Arg Ile Val Pro  Ile Pro Ile 
    1160                 1165                 1170             


Tyr Ile  Ser Gln Asn Ile Lys  Asp Asp Lys Ala Leu  Leu Glu Tyr 
    1175                 1180                 1185             


Ala Gln  Thr Arg Leu Pro Gly  Lys Asp Leu Lys Ile  Lys Tyr Arg 
    1190                 1195                 1200             


Lys Leu  Cys Ile Gly Ser Leu  Val Lys Ile Asn Asn  Phe Asn Tyr 
    1205                 1210                 1215             


Tyr Ile  Gly Gly Lys Thr Asn  Asn Asn Phe Thr Phe  Asp Ser Ala 
    1220                 1225                 1230             


Val Gln  Val Ile Leu Asp Lys  Asp Ser Glu Ser Tyr  Ile Lys Glu 
    1235                 1240                 1245             


Leu Ala  Lys Tyr Leu Asn Trp  Lys Lys Glu Asn Lys  Asp Gly Lys 
    1250                 1255                 1260             


Leu Trp  Glu Ser Ile Thr Glu  Asp Lys Asn Ile Gln  Leu Tyr Asp 
    1265                 1270                 1275             


Ser Leu  Val Lys Lys Met Asn  Thr Gly Ile Phe Ile  Arg Lys Thr 
    1280                 1285                 1290             


Pro Asn  Lys Tyr Thr Glu Leu  Leu Thr Leu Glu Val  Lys Asn Lys 
    1295                 1300                 1305             


Phe Ile  Asn Ile Asp Ile Asp  Glu Gln Val Lys Leu  Leu Leu Glu 
    1310                 1315                 1320             


Ile Leu  Asn Leu Leu Thr Asn  Lys Lys Phe Thr Ser  Lys Leu Asn 
    1325                 1330                 1335             


Glu Ile  Gly Ile Thr Ala Ser  Arg Gly Val Cys Ser  Phe Asn Leu 
    1340                 1345                 1350             


Ser Asn  Gln Ser Gln Phe Ser  Ile Ile Glu Gln Ser  Val Thr Gly 
    1355                 1360                 1365             


Val Tyr  Glu Lys Glu Lys Leu  Ile Ile Glu Lys Lys  Lys Glu Gly 
    1370                 1375                 1380             


Ile Leu  
    1385 


<210> 245
<211> 1003
<212> PRT
<213> Gluconacetobacter diazotrophicus

<400> 245
Met Ile Asp Glu Ser Leu Thr Phe Gly Ile Asp Leu Gly Ile Gly Ser 
1               5                   10                  15      


Cys Gly Trp Ala Val Leu Arg Arg Pro Ser Ala Phe Gly Arg Lys Gly 
            20                  25                  30          


Val Ile Glu Gly Met Gly Ser Trp Cys Phe Asp Val Pro Glu Thr Ser 
        35                  40                  45              


Lys Glu Arg Thr Pro Thr Asn Gln Ile Arg Arg Ser Asn Arg Leu Leu 
    50                  55                  60                  


Arg Arg Val Ile Arg Arg Arg Arg Asn Arg Met Ala Ala Ile Arg Arg 
65                  70                  75                  80  


Leu Leu His Ala Ala Gly Leu Leu Pro Ser Thr Asp Ser Asp Ala Leu 
                85                  90                  95      


Lys Arg Pro Gly His Asp Pro Trp Glu Leu Arg Ala Arg Gly Leu Asp 
            100                 105                 110         


Lys Pro Leu Lys Pro Val Glu Phe Ala Val Val Leu Gly His Ile Ala 
        115                 120                 125             


Lys Arg Arg Gly Phe Lys Ser Ala Ala Lys Arg Lys Ala Thr Asn Ile 
    130                 135                 140                 


Ser Ser Asp Asp Lys Lys Met Leu Thr Ala Leu Glu Ala Thr Arg Glu 
145                 150                 155                 160 


Arg Leu Gly Arg Tyr Arg Thr Val Gly Glu Met Phe Ala Arg Asp Pro 
                165                 170                 175     


Asp Phe Ala Ser Arg Arg Arg Asn Arg Glu Gly Lys Tyr Asp Arg Thr 
            180                 185                 190         


Thr Ala Arg Asp Asp Leu Glu His Glu Val His Ala Leu Phe Ala Ala 
        195                 200                 205             


Gln Arg Arg Leu Gly Gln Gly Phe Ala Ser Pro Glu Leu Glu Glu Ala 
    210                 215                 220                 


Phe Thr Ala Ser Ala Phe His Gln Arg Pro Met Gln Asp Ser Glu Arg 
225                 230                 235                 240 


Leu Val Gly Phe Cys Pro Phe Glu Arg Thr Glu Lys Arg Ala Ala Lys 
                245                 250                 255     


Leu Thr Pro Ser Phe Glu Arg Phe Arg Leu Leu Ala Arg Leu Leu Asn 
            260                 265                 270         


Leu Arg Ile Thr Thr Pro Asp Gly Glu Arg Pro Leu Thr Val Asp Glu 
        275                 280                 285             


Ile Ala Leu Val Thr Arg Asp Leu Gly Lys Thr Ala Lys Leu Ser Ile 
    290                 295                 300                 


Lys Arg Val Arg Thr Leu Ile Gly Leu Glu Asp Asn Gln Arg Phe Thr 
305                 310                 315                 320 


Thr Ile Arg Pro Glu Asp Glu Asp Arg Asp Ile Val Ala Arg Thr Gly 
                325                 330                 335     


Gly Ala Met Thr Gly Thr Ala Thr Leu Arg Lys Ala Leu Gly Glu Ala 
            340                 345                 350         


Leu Trp Thr Asp Met Gln Glu Arg Pro Glu Gln Leu Asp Ala Ile Val 
        355                 360                 365             


Gln Val Leu Ser Phe Phe Glu Ala Asn Glu Thr Ile Thr Glu Lys Leu 
    370                 375                 380                 


Arg Glu Ile Gly Leu Thr Leu Ala Val Leu Asp Val Leu Leu Thr Ala 
385                 390                 395                 400 


Leu Asp Ala Gly Val Phe Ala Lys Phe Lys Gly Ala Ala His Ile Ser 
                405                 410                 415     


Thr Lys Ala Ala Arg Asn Leu Leu Pro His Leu Glu Gln Gly Arg Arg 
            420                 425                 430         


Tyr Asp Glu Ala Cys Thr Met Ala Gly Tyr Asp His Ala Ala Ser Arg 
        435                 440                 445             


Leu Ser His His Gly Gln Ile Val Ala Lys Thr Gln Phe Asn Ala Leu 
    450                 455                 460                 


Val Thr Glu Ile Gly Glu Ser Ile Ala Asn Pro Ile Ala Arg Lys Ala 
465                 470                 475                 480 


Leu Ile Glu Gly Leu Lys Gln Ile Trp Ala Met Arg Asn His Trp Gly 
                485                 490                 495     


Leu Pro Gly Ser Ile His Val Glu Leu Ala Arg Asp Val Gly Asn Ser 
            500                 505                 510         


Ile Glu Lys Arg Arg Glu Ile Glu Lys His Ile Glu Lys Asn Thr Ala 
        515                 520                 525             


Leu Arg Ala Arg Glu Arg Arg Glu Val His Asp Leu Leu Asp Leu Glu 
    530                 535                 540                 


Asp Val Asn Gly Asp Thr Leu Leu Arg Tyr Arg Leu Trp Lys Glu Gln 
545                 550                 555                 560 


Gly Gly Lys Cys Leu Tyr Thr Gly Lys Ala Ile His Ile Arg Gln Ile 
                565                 570                 575     


Ala Ala Thr Asp Asn Ser Val Gln Val Asp His Ile Leu Pro Trp Ser 
            580                 585                 590         


Arg Phe Gly Asp Asp Ser Phe Asn Asn Lys Thr Leu Cys Leu Ala Ser 
        595                 600                 605             


Ala Asn Gln Gln Lys Lys Arg Ser Thr Pro Tyr Glu Trp Leu Ser Gly 
    610                 615                 620                 


Gln Thr Gly Asp Ala Trp Asn Ala Phe Val Gln Arg Ile Glu Thr Asn 
625                 630                 635                 640 


Lys Glu Leu Arg Gly Phe Lys Lys Arg Asn Tyr Leu Leu Lys Asn Ala 
                645                 650                 655     


Lys Glu Ala Glu Glu Lys Phe Arg Ser Arg Asn Leu Asn Asp Thr Arg 
            660                 665                 670         


Tyr Ala Ala Arg Leu Phe Ala Glu Ala Val Lys Leu Leu Tyr Ala Phe 
        675                 680                 685             


Gly Glu Arg Gln Glu Lys Gly Gly Asn Arg Arg Val Phe Thr Arg Pro 
    690                 695                 700                 


Gly Ala Leu Thr Ala Ala Leu Arg Gln Ala Trp Gly Val Glu Ser Leu 
705                 710                 715                 720 


Lys Lys Gln Asp Gly Lys Arg Ile Asn Asp Asp Arg His His Ala Leu 
                725                 730                 735     


Asp Ala Leu Thr Val Ala Ala Val Asp Glu Ala Glu Ile Gln Arg Leu 
            740                 745                 750         


Thr Lys Ser Phe His Glu Trp Glu Gln Gln Gly Leu Gly Arg Pro Leu 
        755                 760                 765             


Arg Arg Val Glu Pro Pro Trp Glu Ser Phe Arg Ala Asp Val Glu Ala 
    770                 775                 780                 


Thr Tyr Pro Glu Val Phe Val Ala Arg Pro Glu Arg Arg Arg Ala Arg 
785                 790                 795                 800 


Gly Glu Gly His Ala Ala Thr Ile Arg Gln Val Lys Glu Arg Glu Cys 
                805                 810                 815     


Thr Pro Ile Val Phe Glu Arg Lys Ala Val Ser Ser Leu Lys Glu Ala 
            820                 825                 830         


Asp Leu Glu Arg Ile Lys Asp Gly Glu Arg Asn Glu Ala Ile Val Glu 
        835                 840                 845             


Ala Ile Arg Ser Trp Ile Ala Thr Gly Arg Pro Ala Asp Ala Pro Pro 
    850                 855                 860                 


Arg Ser Pro Arg Gly Asp Ile Ile Thr Lys Ile Arg Leu Ala Thr Thr 
865                 870                 875                 880 


Ile Lys Ala Ala Val Pro Val Arg Gly Gly Thr Ala Gly Arg Gly Glu 
                885                 890                 895     


Met Val Arg Ala Asp Val Phe Ser Lys Pro Asn Arg Arg Gly Lys Asp 
            900                 905                 910         


Glu Trp Tyr Leu Val Pro Val Tyr Pro His Gln Ile Met Asn Arg Lys 
        915                 920                 925             


Ala Trp Pro Lys Pro Pro Met Arg Ser Ile Val Ala Asn Lys Asp Glu 
    930                 935                 940                 


Asp Glu Trp Thr Glu Val Gly Pro Glu His Gln Phe Arg Phe Ser Leu 
945                 950                 955                 960 


Tyr Pro Arg Ser Asn Ile Glu Ile Ile Arg Pro Ser Gly Glu Val Ile 
                965                 970                 975     


Glu Gly Tyr Phe Val Gly Leu His Arg Asn Thr Gly Ala Leu Ile Pro 
            980                 985                 990         


Thr Pro Val Gly Pro Asp Ser Tyr  Val Ile Ala 
        995                 1000             


<210> 246
<211> 1050
<212> PRT
<213> Gluconacetobacter diazotrophicus

<400> 246
Met Gly Glu Asn Met Ile Asp Glu Ser Leu Thr Phe Gly Ile Asp Leu 
1               5                   10                  15      


Gly Ile Gly Ser Cys Gly Trp Ala Val Leu Arg Arg Pro Ser Ala Phe 
            20                  25                  30          


Gly Arg Lys Gly Val Ile Glu Gly Met Gly Ser Trp Cys Phe Asp Val 
        35                  40                  45              


Pro Glu Thr Ser Lys Glu Arg Thr Pro Thr Asn Gln Ile Arg Arg Ser 
    50                  55                  60                  


Asn Arg Leu Leu Arg Arg Val Ile Arg Arg Arg Arg Asn Arg Met Ala 
65                  70                  75                  80  


Ala Ile Arg Arg Leu Leu His Ala Ala Gly Leu Leu Pro Ser Thr Asp 
                85                  90                  95      


Ser Asp Ala Leu Lys Arg Pro Gly His Asp Pro Trp Glu Leu Arg Ala 
            100                 105                 110         


Arg Gly Leu Asp Lys Pro Leu Lys Pro Val Glu Phe Ala Val Val Leu 
        115                 120                 125             


Gly His Ile Ala Lys Arg Arg Gly Phe Lys Ser Ala Ala Lys Arg Lys 
    130                 135                 140                 


Ala Thr Asn Ile Ser Ser Asp Asp Lys Lys Met Leu Thr Ala Leu Glu 
145                 150                 155                 160 


Ala Thr Arg Glu Arg Leu Gly Arg Tyr Arg Thr Val Gly Glu Met Phe 
                165                 170                 175     


Ala Arg Asp Pro Asp Phe Ala Ser Arg Arg Arg Asn Arg Glu Gly Lys 
            180                 185                 190         


Tyr Asp Arg Thr Thr Ala Arg Asp Asp Leu Glu His Glu Val His Ala 
        195                 200                 205             


Leu Phe Ala Ala Gln Arg Arg Leu Gly Gln Gly Phe Ala Ser Pro Glu 
    210                 215                 220                 


Leu Glu Glu Ala Phe Thr Ala Ser Ala Phe His Gln Arg Pro Met Gln 
225                 230                 235                 240 


Asp Ser Glu Arg Leu Val Gly Phe Cys Pro Phe Glu Arg Thr Glu Lys 
                245                 250                 255     


Arg Ala Ala Lys Leu Thr Pro Ser Phe Glu Arg Phe Arg Leu Leu Ala 
            260                 265                 270         


Arg Leu Leu Asn Leu Arg Ile Thr Thr Pro Asp Gly Glu Arg Pro Leu 
        275                 280                 285             


Thr Val Asp Glu Ile Ala Leu Val Thr Arg Asp Leu Gly Lys Thr Ala 
    290                 295                 300                 


Lys Leu Ser Ile Lys Arg Val Arg Thr Leu Ile Gly Leu Glu Asp Asn 
305                 310                 315                 320 


Gln Arg Phe Thr Thr Ile Arg Pro Glu Asp Glu Asp Arg Asp Ile Val 
                325                 330                 335     


Ala Arg Thr Gly Gly Ala Met Thr Gly Thr Ala Thr Leu Arg Lys Ala 
            340                 345                 350         


Leu Gly Glu Ala Leu Trp Thr Asp Met Gln Glu Arg Pro Glu Gln Leu 
        355                 360                 365             


Asp Ala Ile Val Gln Val Leu Ser Phe Phe Glu Ala Asn Glu Thr Ile 
    370                 375                 380                 


Thr Glu Lys Leu Arg Glu Ile Gly Leu Thr Leu Ala Val Leu Asp Val 
385                 390                 395                 400 


Leu Leu Thr Ala Leu Asp Ala Gly Val Phe Ala Lys Phe Lys Gly Ala 
                405                 410                 415     


Ala His Ile Ser Thr Lys Ala Ala Arg Asn Leu Leu Pro His Leu Glu 
            420                 425                 430         


Gln Gly Arg Arg Tyr Asp Glu Ala Cys Thr Met Ala Gly Tyr Asp His 
        435                 440                 445             


Ala Ala Ser Arg Leu Ser His His Gly Gln Ile Val Ala Lys Thr Gln 
    450                 455                 460                 


Phe Asn Ala Leu Val Thr Glu Ile Gly Glu Ser Ile Ala Asn Pro Ile 
465                 470                 475                 480 


Ala Arg Lys Ala Leu Ile Glu Gly Leu Lys Gln Ile Trp Ala Met Arg 
                485                 490                 495     


Asn His Trp Gly Leu Pro Gly Ser Ile His Val Glu Leu Ala Arg Asp 
            500                 505                 510         


Val Gly Asn Ser Ile Glu Lys Arg Arg Glu Ile Glu Lys His Ile Glu 
        515                 520                 525             


Lys Asn Thr Ala Leu Arg Ala Arg Glu Arg Arg Glu Val His Asp Leu 
    530                 535                 540                 


Leu Asp Leu Glu Asp Val Asn Gly Asp Thr Leu Leu Arg Tyr Arg Leu 
545                 550                 555                 560 


Trp Lys Glu Gln Gly Gly Lys Cys Leu Tyr Thr Gly Lys Ala Ile His 
                565                 570                 575     


Ile Arg Gln Ile Ala Ala Thr Asp Asn Ser Val Gln Val Asp His Ile 
            580                 585                 590         


Leu Pro Trp Ser Arg Phe Gly Asp Asp Ser Phe Asn Asn Lys Thr Leu 
        595                 600                 605             


Cys Leu Ala Ser Ala Asn Gln Gln Lys Lys Arg Ser Thr Pro Tyr Glu 
    610                 615                 620                 


Trp Leu Ser Gly Gln Thr Gly Asp Ala Trp Asn Ala Phe Val Gln Arg 
625                 630                 635                 640 


Ile Glu Thr Asn Lys Glu Leu Arg Gly Phe Lys Lys Arg Asn Tyr Leu 
                645                 650                 655     


Leu Lys Asn Ala Lys Glu Ala Glu Glu Lys Phe Arg Ser Arg Asn Leu 
            660                 665                 670         


Asn Asp Thr Arg Tyr Ala Ala Arg Leu Phe Ala Glu Ala Val Lys Leu 
        675                 680                 685             


Leu Tyr Ala Phe Gly Glu Arg Gln Glu Lys Gly Gly Asn Arg Arg Val 
    690                 695                 700                 


Phe Thr Arg Pro Gly Ala Leu Thr Ala Ala Leu Arg Gln Ala Trp Gly 
705                 710                 715                 720 


Val Glu Ser Leu Lys Lys Gln Asp Gly Lys Arg Ile Asn Asp Asp Arg 
                725                 730                 735     


His His Ala Leu Asp Ala Leu Thr Val Ala Ala Val Asp Glu Ala Glu 
            740                 745                 750         


Ile Gln Arg Leu Thr Lys Ser Phe His Glu Trp Glu Gln Gln Gly Leu 
        755                 760                 765             


Gly Arg Pro Leu Arg Arg Val Glu Pro Pro Trp Glu Ser Phe Arg Ala 
    770                 775                 780                 


Asp Val Glu Ala Thr Tyr Pro Glu Val Phe Val Ala Arg Pro Glu Arg 
785                 790                 795                 800 


Arg Arg Ala Arg Gly Glu Gly His Ala Ala Thr Ile Arg Gln Val Lys 
                805                 810                 815     


Glu Arg Glu Cys Thr Pro Ile Val Phe Glu Arg Lys Ala Val Ser Ser 
            820                 825                 830         


Leu Lys Glu Ala Asp Leu Glu Arg Ile Lys Asp Gly Glu Arg Asn Glu 
        835                 840                 845             


Ala Ile Val Glu Ala Ile Arg Ser Trp Ile Ala Thr Gly Arg Pro Ala 
    850                 855                 860                 


Asp Ala Pro Pro Arg Ser Pro Arg Gly Asp Ile Ile Thr Lys Ile Arg 
865                 870                 875                 880 


Leu Ala Thr Thr Ile Lys Ala Ala Val Pro Val Arg Gly Gly Thr Ala 
                885                 890                 895     


Gly Arg Gly Glu Met Val Arg Ala Asp Val Phe Ser Lys Pro Asn Arg 
            900                 905                 910         


Arg Gly Lys Asp Glu Trp Tyr Leu Val Pro Val Tyr Pro His Gln Ile 
        915                 920                 925             


Met Asn Arg Lys Ala Trp Pro Lys Pro Pro Met Arg Ser Ile Val Ala 
    930                 935                 940                 


Asn Lys Asp Glu Asp Glu Trp Thr Glu Val Gly Pro Glu His Gln Phe 
945                 950                 955                 960 


Arg Phe Ser Leu Tyr Pro Arg Ser Asn Ile Glu Ile Ile Arg Pro Ser 
                965                 970                 975     


Gly Glu Val Ile Glu Gly Tyr Phe Val Gly Leu His Arg Asn Thr Gly 
            980                 985                 990         


Ala Leu Thr Ile Ser Ala His Asn  Asp Pro Lys Ser Ile  His Ser Gly 
        995                 1000                 1005             


Ile Gly  Thr Lys Thr Leu Leu  Ala Ile Ser Lys Tyr  Gln Val Asp 
    1010                 1015                 1020             


Arg Phe  Gly Arg Lys Ser Pro  Val Arg Lys Glu Val  Arg Thr Trp 
    1025                 1030                 1035             


His Gly  Glu Ala Cys Ile Ser  Pro Thr Pro Pro Gly  
    1040                 1045                 1050 


<210> 247
<211> 1371
<212> PRT
<213> Gordonibacter pamelaeae


<220>
<223> Gordonibacter pamelaeae 7-10-1-b

<400> 247
Met Asn Leu Arg Asn Val Glu Ser Tyr Gln Val Gly Leu Asp Ile Gly 
1               5                   10                  15      


Thr Gly Ser Val Gly Trp Ala Val Leu Asp Asp Asn Gly Asp Leu Cys 
            20                  25                  30          


Arg Phe Lys Gly Lys Pro Thr Trp Gly Ser Arg Val Phe Pro Thr Ala 
        35                  40                  45              


Glu Thr Ala Ala Glu Ala Arg Val His Arg Gly Gln Arg Arg Arg Tyr 
    50                  55                  60                  


Asp Arg Arg Arg Gln Arg Ile Asp Leu Leu Gln Arg Phe Phe Ala Asp 
65                  70                  75                  80  


Glu Val Ala Lys Val Asp Pro Glu Phe Phe Ile Arg Leu Asn Gln Ala 
                85                  90                  95      


Arg Leu His Pro Glu Asn Arg Asp Pro Ala His Ala Asp Tyr Arg Trp 
            100                 105                 110         


Pro Leu Phe Asn Gly Ser Asn Phe Thr Glu Lys Asp Tyr Tyr Arg Gln 
        115                 120                 125             


Phe Pro Thr Ile Tyr His Leu Arg Ala His Leu Leu Lys Ser Asp Glu 
    130                 135                 140                 


Pro Ala Asp Ile Arg Leu Val Tyr Leu Ala Leu His Asn Ile Val Lys 
145                 150                 155                 160 


His Arg Gly Asn Phe Leu His Gln Asp Asn Pro Ser Leu Ser Ala Arg 
                165                 170                 175     


Asn Ala Asn Val Gly Asp Ala Val Glu Ala Leu Cys Leu Ala Leu Asp 
            180                 185                 190         


Glu Trp Cys Gly Ala His Asp Val Glu Cys Ala Cys Asp Glu Ala Ala 
        195                 200                 205             


Leu Ala Glu Ala Leu Gly Asp Ala Ser Leu Arg Pro Gly Glu Lys Arg 
    210                 215                 220                 


Glu Arg Ala Glu Ala Ala Leu Gly Val Glu Lys Ala His Lys Lys Leu 
225                 230                 235                 240 


Ala Lys Ala Val Ser Ser Ala Val Val Gly Tyr Ala Ala Glu Phe Gly 
                245                 250                 255     


His Val Phe Phe Ala Glu Ser Glu Gly Ser Lys Phe Ala Leu Ser Asn 
            260                 265                 270         


Asp Glu Lys Val Glu Ala Tyr Val Cys Pro Asp Glu Gly Arg Asp Leu 
        275                 280                 285             


Phe Asp Ala Met Arg Ala Val His Ser Ser Tyr Val Leu Met Gly Ile 
    290                 295                 300                 


Leu Ser Glu Ala Gln Gly Glu Leu Leu Ser Val Cys Lys Val Gly Glu 
305                 310                 315                 320 


Tyr Glu Arg Tyr Lys Arg Asp Leu Glu Thr Leu Lys Ser Leu Val Arg 
                325                 330                 335     


Ala Tyr Gly Pro Glu Arg Tyr Asp Glu Phe Phe Cys Gly Pro Phe Tyr 
            340                 345                 350         


Glu Gly Thr Arg Asp Tyr Asp Pro Gly Lys Ala Gln Gly Tyr Thr Lys 
        355                 360                 365             


Tyr Asn Leu Gly Ala Ser Lys Leu Ser His Glu Asp Phe Leu Lys Glu 
    370                 375                 380                 


Val Gln Lys Leu Leu Lys Asp Ile Gly Ala Gln Ala Asp Glu Arg Tyr 
385                 390                 395                 400 


Ala Asp Ile Glu Arg Ala Ile Glu Ala Gly Ala Phe Leu Arg Arg Leu 
                405                 410                 415     


Lys Thr Ser Asp Asn Gly Thr Ile Pro Tyr Gln Leu His Leu Glu Glu 
            420                 425                 430         


Met Asp Ala Ile Ile Glu Arg Gln Ala Ala Phe Tyr Pro Phe Leu Ala 
        435                 440                 445             


Gln Glu Lys Asp Lys Leu Lys Ser Leu Val Ser Phe Arg Ile Pro Tyr 
    450                 455                 460                 


Tyr Val Gly Pro Leu Thr Gln Lys Asn Ala Ala Arg Asp Gly Lys Gly 
465                 470                 475                 480 


Glu Ala Arg Phe Ala Trp Ser Ser Arg Lys Pro Gly Met Glu Asp Ala 
                485                 490                 495     


Arg Val Tyr Pro Trp Asn Trp Glu Asp Val Ile Asp Lys Asp Gln Ser 
            500                 505                 510         


Ala Glu Asp Phe Ile Arg Arg Met Thr Gly Thr Cys Thr Tyr Leu Lys 
        515                 520                 525             


Gly Glu Pro Val Leu Ala Arg Cys Ser Leu Asp Tyr Glu Leu Phe Cys 
    530                 535                 540                 


Val Leu Asn Glu Leu Ala Gly Ala Arg Trp Thr Gln Asp Gly Asp Lys 
545                 550                 555                 560 


Ser Tyr Arg Phe Asp Ala Ala Asp Arg Leu Gly Ile Val Glu Asp Leu 
                565                 570                 575     


Phe Lys Lys Arg Lys Arg Val Thr Tyr Glu Ala Ala Glu Lys Trp Leu 
            580                 585                 590         


Ala Arg Thr His Gly Pro Glu Ser Gly Lys Ser Ala Gly Gly Ala Tyr 
        595                 600                 605             


His Val Ser Gly Gly Gln Gly Glu Asp Ala Phe Glu Ser Gln Leu Ser 
    610                 615                 620                 


Ser His Tyr Asp Phe Cys Lys Ile Leu Gly Val Asp Glu Leu Ser Asp 
625                 630                 635                 640 


Ala Asp Glu Ala Met Ala Glu Asp Ile Ile Leu Trp Asn Thr Val Phe 
                645                 650                 655     


Glu Asp Arg Ser Ile Leu Lys Arg Lys Ile Lys Leu Ala Tyr Gly Asp 
            660                 665                 670         


Arg Leu Gly Asp Ala Gln Val Arg Lys Leu Cys Gln Lys Arg Tyr Thr 
        675                 680                 685             


Gly Trp Gly Arg Leu Ser Gly Glu Leu Leu Arg Gly Leu Arg Ser Ala 
    690                 695                 700                 


Thr Asp Asn Gly Pro Lys Thr Ile Met Asp Ile Leu Leu Glu Gly Asp 
705                 710                 715                 720 


Pro Asn His Ala Arg Arg Met Gly Ala Ala Met Asn Leu Met Glu Ile 
                725                 730                 735     


Leu His Asp Asp Leu Leu Glu Phe Gln Ala Lys Ile Asp Glu His Asn 
            740                 745                 750         


Arg Glu Arg Ala Leu Ala Val Gly Gly Met Ser Val Asp Glu Val Thr 
        755                 760                 765             


Gly Ser Pro Ala Leu Arg Arg Gly Ile Asn Gln Ala Leu Arg Val Val 
    770                 775                 780                 


Asp Glu Ile Ala Gly Ile Ala Gly Lys Pro Pro Ala His Ile Tyr Val 
785                 790                 795                 800 


Glu Val Thr Arg Asp Glu Gly Ala Arg Asn Lys Gly Arg Arg Thr Thr 
                805                 810                 815     


Ser Arg Tyr Arg Ala Leu Glu Ala Ala Leu Ser Ser Ile Lys Ala Gln 
            820                 825                 830         


Cys Ala Asp Val Tyr Ala Glu Leu Lys Glu Arg Asp Pro Arg Ala Leu 
        835                 840                 845             


Asp Asp Glu Arg Leu Thr Leu Tyr Phe Met Gln Cys Gly Lys Cys Met 
    850                 855                 860                 


Tyr Ser Gly Asp Ala Leu Asp Ile Asn Lys Leu Gln Thr Tyr Gln Val 
865                 870                 875                 880 


Asp His Ile Leu Pro Gln Ser Tyr Val Lys Asp Asp Ser Phe Glu Asn 
                885                 890                 895     


Lys Val Leu Val Arg Pro Asp Thr Asn Gln Arg Lys Gly Asp Thr Leu 
            900                 905                 910         


Leu Leu Asp Glu Arg Leu Ile Ala Arg Met Arg Gly Phe Trp Arg Thr 
        915                 920                 925             


Leu Arg Asp Ala Glu Leu Ile Gly Glu Lys Lys Phe Asn Asn Leu Thr 
    930                 935                 940                 


Arg Thr Ser Val Ser Asp Glu Gln Met Lys Lys Phe Val Ser Arg Gln 
945                 950                 955                 960 


Leu Val Glu Thr Gly Gln Met Val Lys Gln Val Gln Gln Leu Leu Gln 
                965                 970                 975     


Ala Arg Tyr Pro Glu Ser Glu Val Gln Pro Val Lys Ala Gly Val Ser 
            980                 985                 990         


His Gln Leu Arg Val Gly Cys Ala  Leu Ala Lys Ser Arg  Glu Ile Asn 
        995                 1000                 1005             


Asp Phe  His His Ala His Asp  Ala Tyr Leu Ala Cys  Gln Val Gly 
    1010                 1015                 1020             


Arg Phe  Val Gln Tyr Arg His  Ser Ala Val Tyr Ser  Glu Pro Val 
    1025                 1030                 1035             


Lys Met  Ala Ala Val Val Lys  Gln Phe Ile Lys Lys  Gln Ala Glu 
    1040                 1045                 1050             


Asp Tyr  Arg Arg Thr Arg Glu  Leu Pro Gly Ser Asp  Gly Phe Ile 
    1055                 1060                 1065             


Val Ser  Ser Phe Met Thr Pro  Gly Phe Asp Val Lys  Thr Gly Glu 
    1070                 1075                 1080             


Val Phe  Arg Asp Ala Trp Asp  Ala Gly Ala Glu Ile  Asp Arg Ile 
    1085                 1090                 1095             


Arg Arg  Cys Phe Asp Tyr Lys  Asp Cys Phe Ile Ser  Arg Met Pro 
    1100                 1105                 1110             


Glu Glu  Thr His Gly Ala Phe  Trp Asp Ala Thr Ile  Tyr Ser Pro 
    1115                 1120                 1125             


Arg Ala  Ala Gly Lys Thr Leu  Ser Leu Pro Leu Lys  Arg Gly Leu 
    1130                 1135                 1140             


Asp Pro  Arg Lys Tyr Gly Ser  Tyr Ser Arg Glu Gln  Phe Ala Tyr 
    1145                 1150                 1155             


Phe Phe  Val Tyr Glu Ala Val  Lys Pro Lys Lys Lys  Gln Arg Val 
    1160                 1165                 1170             


Leu Glu  Phe Ala Pro Val Pro  Val Arg Val Ala Ser  Ala Leu Ala 
    1175                 1180                 1185             


Asn Asp  Pro Asp Ala Leu Glu  Asp Tyr Ala Arg Glu  Leu Ala Glu 
    1190                 1195                 1200             


Ala Glu  Gly Leu Val Phe Glu  Arg Ile Arg Arg Arg  Lys Val Tyr 
    1205                 1210                 1215             


Lys Tyr  Gln Gln Ile Ile Val  Gly Asp Ser Arg Leu  Tyr Val Thr 
    1220                 1225                 1230             


Gly Arg  Glu Glu Val Arg Asn  Ala Arg Gln Leu Ala  Phe Ser Gln 
    1235                 1240                 1245             


Asp Glu  Thr Lys Leu Ile Cys  Arg Ile Glu Gln Gly  Glu Glu Cys 
    1250                 1255                 1260             


Glu Glu  Gly Glu Leu Leu Asp  Leu Phe Arg Ser Met  Gln Arg Lys 
    1265                 1270                 1275             


Tyr Leu  Ala Cys Ala Pro Arg  Leu Ala Arg Leu Met  Lys Val Ala 
    1280                 1285                 1290             


Glu Met  Glu Glu Gly Phe Ile  Ala Ala Thr Ala Ser  Gly Lys Arg 
    1295                 1300                 1305             


Glu Val  Leu Leu Ser Leu Thr  Ser Ile Ala Ala Ala  His Arg Asn 
    1310                 1315                 1320             


Ser Ile  Asp Leu Lys Pro Ile  Gly Arg Lys Gly Ser  Ser Gly Gln 
    1325                 1330                 1335             


Met Lys  Ile Thr Phe Ser Lys  Glu Leu Ser Thr Asn  Gly Ile Leu 
    1340                 1345                 1350             


Phe Val  Asp Ser Ser Val Thr  Gly Met Phe Glu Arg  Arg Cys Arg 
    1355                 1360                 1365             


Leu Gly  Leu 
    1370     


<210> 248
<211> 1054
<212> PRT
<213> Haemophilus parainfluenzae


<220>
<223> Haemophilus parainfluenzae ATCC 33392

<400> 248
Met Glu Asn Lys Asn Leu Asn Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Val Val Glu Ile Asp Glu Lys Glu Asn Pro 
            20                  25                  30          


Leu Arg Leu Ile Asp Val Gly Val Arg Thr Phe Glu Arg Ala Glu Val 
        35                  40                  45              


Pro Lys Thr Gly Glu Ser Leu Ala Leu Ser Arg Arg Leu Ala Arg Ser 
    50                  55                  60                  


Ala Arg Arg Leu Thr Gln Arg Arg Val Ala Arg Leu Lys Lys Ala Lys 
65                  70                  75                  80  


Arg Leu Leu Lys Ser Glu Asn Ile Leu Leu Ser Thr Asp Glu Arg Leu 
                85                  90                  95      


Pro His Gln Val Trp Gln Leu Arg Val Glu Gly Leu Asp His Lys Leu 
            100                 105                 110         


Glu Arg Gln Glu Trp Ala Ala Val Leu Leu His Leu Ile Lys His Arg 
        115                 120                 125             


Gly Tyr Leu Ser Gln Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu 
    130                 135                 140                 


Leu Gly Ala Leu Leu Ser Gly Val Asp Asn Asn His Lys Leu Leu Gln 
145                 150                 155                 160 


Gln Ala Thr Tyr Arg Ser Pro Ala Glu Leu Ala Val Lys Lys Phe Glu 
                165                 170                 175     


Val Glu Glu Gly His Ile Arg Asn Gln Gln Gly Ala Tyr Thr His Thr 
            180                 185                 190         


Phe Ser Arg Leu Asp Leu Leu Ala Glu Met Glu Leu Leu Phe Ser Arg 
        195                 200                 205             


Gln Gln His Phe Gly Asn Pro Phe Ala Ser Glu Lys Leu Leu Glu Asn 
    210                 215                 220                 


Leu Thr Ala Leu Leu Met Trp Gln Lys Pro Ala Leu Ser Gly Glu Ala 
225                 230                 235                 240 


Ile Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Asp Glu Tyr Lys Ala 
                245                 250                 255     


Ala Lys Asn Thr Tyr Ser Ala Glu Arg Phe Val Trp Ile Thr Lys Leu 
            260                 265                 270         


Asn Asn Leu Arg Ile Gln Glu Asn Gly Leu Glu Arg Ala Leu Asn Asp 
        275                 280                 285             


Asn Glu Arg Leu Ala Leu Met Glu Gln Pro Tyr Asp Lys Asn Arg Leu 
    290                 295                 300                 


Phe Tyr Ser Gln Val Arg Ser Ile Leu Lys Leu Ser Asp Glu Ala Ile 
305                 310                 315                 320 


Phe Lys Gly Leu Arg Tyr Ser Gly Glu Asp Lys Lys Ala Ile Glu Thr 
                325                 330                 335     


Lys Ala Val Leu Met Glu Met Lys Ala Tyr His Gln Ile Arg Lys Val 
            340                 345                 350         


Leu Glu Gly Asn Asn Leu Lys Ala Glu Trp Ala Glu Leu Lys Ala Asn 
        355                 360                 365             


Pro Thr Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr 
    370                 375                 380                 


Asp Glu Asp Ile Ser Ala Tyr Leu Ala Gly Lys Leu Ser Gln Pro Val 
385                 390                 395                 400 


Leu Asn Ala Leu Leu Glu Asn Leu Ser Phe Asp Lys Phe Ile Gln Leu 
                405                 410                 415     


Ser Leu Lys Ala Leu Tyr Lys Leu Leu Pro Leu Met Gln Gln Gly Leu 
            420                 425                 430         


Arg Tyr Asp Glu Ala Cys Arg Glu Ile Tyr Gly Asp His Tyr Gly Lys 
        435                 440                 445             


Lys Thr Glu Glu Asn His His Phe Leu Pro Gln Ile Pro Ala Asp Glu 
    450                 455                 460                 


Ile Arg Asn Pro Val Val Leu Arg Thr Leu Thr Gln Ala Arg Lys Val 
465                 470                 475                 480 


Ile Asn Gly Val Val Arg Leu Tyr Gly Ser Pro Ala Arg Ile His Ile 
                485                 490                 495     


Glu Thr Gly Arg Glu Val Gly Lys Ser Tyr Lys Asp Arg Arg Glu Leu 
            500                 505                 510         


Glu Lys Arg Gln Glu Glu Asn Arg Lys Gln Arg Glu Asn Ala Ile Lys 
        515                 520                 525             


Glu Phe Lys Glu Tyr Phe Pro His Phe Ala Gly Glu Pro Lys Ala Lys 
    530                 535                 540                 


Asp Ile Leu Lys Met Arg Leu Tyr Lys Gln Gln Asn Ala Lys Cys Leu 
545                 550                 555                 560 


Tyr Ser Gly Lys Pro Ile Glu Leu His Arg Leu Leu Glu Lys Gly Tyr 
                565                 570                 575     


Val Glu Val Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser 
            580                 585                 590         


Phe Asn Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gln Asn Lys Gly 
        595                 600                 605             


Asn Leu Thr Pro Phe Glu Trp Leu Asp Gly Lys His Asn Ser Glu Arg 
    610                 615                 620                 


Trp Arg Ala Phe Lys Ala Leu Val Glu Thr Ser Ala Phe Pro Tyr Ala 
625                 630                 635                 640 


Lys Lys Gln Arg Ile Leu Ser Gln Lys Leu Asp Glu Lys Gly Phe Ile 
                645                 650                 655     


Glu Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys Asn 
            660                 665                 670         


Phe Ile Ala Asp Asn Met His Leu Thr Gly Glu Gly Lys Arg Lys Val 
        675                 680                 685             


Phe Ala Ser Asn Gly Gln Ile Thr Ala Leu Leu Arg Ser Arg Trp Gly 
    690                 695                 700                 


Leu Ala Lys Ser Arg Glu Asp Asn Asp Arg His His Ala Leu Asp Ala 
705                 710                 715                 720 


Val Val Val Ala Cys Ser Thr Val Ala Met Gln Gln Lys Ile Thr Arg 
                725                 730                 735     


Phe Val Arg Phe Glu Ala Gly Asp Val Phe Thr Gly Glu Arg Ile Asp 
            740                 745                 750         


Arg Glu Thr Gly Glu Ile Ile Pro Leu His Phe Pro Thr Pro Trp Gln 
        755                 760                 765             


Phe Phe Lys Gln Glu Val Glu Ile Arg Ile Phe Ser Asp Asn Pro Lys 
    770                 775                 780                 


Leu Glu Leu Glu Asn Arg Leu Pro Asp Arg Pro Gln Ala Asn His Glu 
785                 790                 795                 800 


Phe Val Gln Pro Leu Phe Val Ser Arg Met Pro Thr Arg Lys Met Thr 
                805                 810                 815     


Gly Gln Gly His Met Glu Thr Val Lys Ser Ala Lys Arg Leu Asn Glu 
            820                 825                 830         


Gly Ile Ser Val Ile Lys Met Pro Leu Thr Lys Leu Lys Leu Lys Asp 
        835                 840                 845             


Leu Glu Leu Met Val Asn Arg Glu Arg Glu Lys Asp Leu Tyr Asp Thr 
    850                 855                 860                 


Leu Lys Ala Arg Leu Glu Ala Phe Asn Asp Asp Pro Ala Lys Ala Phe 
865                 870                 875                 880 


Ala Glu Pro Phe Ile Lys Lys Gly Gly Ala Ile Val Lys Ser Val Arg 
                885                 890                 895     


Val Glu Gln Ile Gln Lys Ser Gly Val Leu Val Arg Glu Gly Asn Gly 
            900                 905                 910         


Val Ala Asp Asn Ala Ser Met Val Arg Val Asp Val Phe Thr Lys Gly 
        915                 920                 925             


Gly Lys Tyr Phe Leu Val Pro Ile Tyr Thr Trp Gln Val Ala Lys Gly 
    930                 935                 940                 


Ile Leu Pro Asn Lys Ala Ala Thr Gln Tyr Lys Asp Glu Glu Asp Trp 
945                 950                 955                 960 


Glu Val Met Asp Asn Ser Ala Thr Phe Lys Phe Ser Leu His Pro Asn 
                965                 970                 975     


Asp Leu Val Lys Leu Val Thr Lys Lys Lys Thr Ile Leu Gly Tyr Phe 
            980                 985                 990         


Asn Gly Leu Asn Arg Ala Thr Gly  Asn Ile Asp Ile Lys  Glu His Asp 
        995                 1000                 1005             


Leu Asp  Lys Ser Lys Gly Lys  Gln Gly Ile Phe Glu  Gly Val Gly 
    1010                 1015                 1020             


Ile Lys  Leu Ala Leu Ser Phe  Glu Lys Tyr Gln Val  Asp Glu Leu 
    1025                 1030                 1035             


Gly Lys  Asn Ile Arg Leu Cys  Lys Pro Ser Lys Arg  Gln Pro Val 
    1040                 1045                 1050             


Arg 
    


<210> 249
<211> 1052
<212> PRT
<213> Haemophilus sputorum


<220>
<223> Haemophilus sputorum CCUG 13788

<400> 249
Met Lys Asn Thr Ser Leu Asn Tyr Val Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ser Ser Val Gly Trp Ala Val Val Glu Ile Asp Glu Lys Glu Asn Pro 
            20                  25                  30          


Leu Ser Leu Ile Asp Val Gly Val Arg Thr Phe Glu Arg Ala Glu Thr 
        35                  40                  45              


Gln Lys Gly Glu Ser Leu Ala Leu Ala Arg Arg Leu Ala Arg Ser Ala 
    50                  55                  60                  


Arg Arg Leu Thr Gln Arg Arg Val Ala Arg Leu Lys Lys Ala Lys Arg 
65                  70                  75                  80  


Leu Leu Lys Ser Glu Asn Ile Leu Leu Ser Thr Asp Glu Cys Leu Pro 
                85                  90                  95      


His Gln Val Trp Gln Leu Arg Val Glu Gly Leu Glu Arg Lys Leu Glu 
            100                 105                 110         


Arg Gln Glu Trp Ala Ala Val Leu Leu His Leu Ile Lys His Arg Gly 
        115                 120                 125             


Tyr Leu Ser Gln Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu Leu 
    130                 135                 140                 


Gly Ala Leu Leu Ser Gly Val Ala Asn Asn His Lys Leu Leu Gln Gln 
145                 150                 155                 160 


Thr Thr Tyr Arg Thr Pro Ala Glu Leu Ala Val Lys Lys Phe Glu Val 
                165                 170                 175     


Glu Glu Gly His Ile Arg Asn Gln Gln Gly Ser Tyr Thr His Thr Phe 
            180                 185                 190         


Ser Arg Leu Asp Leu Leu Ser Glu Met Glu Leu Leu Phe Ser Arg Gln 
        195                 200                 205             


Gln His Phe Gly Asn Pro Phe Thr Ser Glu Lys Leu Leu Glu Asn Leu 
    210                 215                 220                 


Thr Ala Leu Leu Met Trp Gln Lys Pro Ala Leu Ser Gly Asp Ala Ile 
225                 230                 235                 240 


Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Asn Glu Tyr Lys Ala Ala 
                245                 250                 255     


Lys His Thr Tyr Ser Ala Glu Arg Phe Ile Trp Ile Thr Lys Leu Asn 
            260                 265                 270         


Asn Leu Arg Ile Gln Glu Asn Gly Leu Glu Arg Ala Leu Asn Asp Asn 
        275                 280                 285             


Glu Arg Leu Ala Leu Met Lys Gln Pro Tyr Glu Lys Ala Lys Leu Thr 
    290                 295                 300                 


Tyr Ala Gln Val Arg Ser Ile Leu Asn Leu Ser Asp Glu Ala Ile Phe 
305                 310                 315                 320 


Lys Gly Leu Arg Tyr Ser Gly Glu Asp Lys Lys Thr Ser Glu Thr Lys 
                325                 330                 335     


Thr Val Leu Met Glu Met Lys Ala Tyr His Gln Ile Arg Leu Ala Leu 
            340                 345                 350         


Glu Lys Asn Asp Leu Lys Thr Glu Trp Ala Glu Leu Lys Val Asn Ser 
        355                 360                 365             


Ser Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp 
    370                 375                 380                 


Glu Asp Ile Ser Thr Cys Leu Ala Gly Lys Leu Ser Gln Pro Val Leu 
385                 390                 395                 400 


Asn Ala Leu Leu Glu Asn Leu Asn Phe Asp Lys Phe Ile Gln Leu Ser 
                405                 410                 415     


Leu Lys Ala Leu His Lys Ile Leu Pro Leu Met Gln Gln Gly Leu Arg 
            420                 425                 430         


Tyr Asp Glu Ala Cys Ala Glu Ile Tyr Gly Asp His Tyr Gly Lys Lys 
        435                 440                 445             


Thr Glu Glu Asn His Leu Leu Leu Pro Gln Ile Pro Ala Asp Glu Ile 
    450                 455                 460                 


Arg Asn Pro Val Val Leu Arg Thr Leu Thr Gln Ala Arg Lys Val Ile 
465                 470                 475                 480 


Asn Gly Val Val Arg Leu Tyr Ser Ser Pro Ala Arg Ile His Ile Glu 
                485                 490                 495     


Thr Gly Arg Glu Val Gly Lys Ser Tyr Gln Asp Arg Arg Glu Leu Glu 
            500                 505                 510         


Lys Arg Gln Glu Glu Asn Arg Lys Gln Arg Glu Lys Ala Ile Ser Glu 
        515                 520                 525             


Ile Lys Thr Leu Phe Pro Asn Phe Ser Gly Glu Pro Lys Ala Lys Asp 
    530                 535                 540                 


Ile Leu Lys Met Arg Leu Tyr Tyr Gln Gln Asn Ala Lys Cys Leu Tyr 
545                 550                 555                 560 


Ser Gly Lys Pro Leu Glu Leu His Arg Leu Leu Glu Gln Gly Tyr Val 
                565                 570                 575     


Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe 
            580                 585                 590         


Asn Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gln Asn Lys Gly Asn 
        595                 600                 605             


Leu Thr Pro Phe Glu Trp Leu Asp Gly Lys Asn Asn Ser Glu Arg Trp 
    610                 615                 620                 


Lys Ala Phe Lys Ala Leu Val Glu Thr Ser Ala Phe Pro Tyr Thr Lys 
625                 630                 635                 640 


Lys Gln Arg Ile Leu Ser Gln Lys Leu Asp Glu Lys Gly Phe Ile Glu 
                645                 650                 655     


Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys Asn Phe 
            660                 665                 670         


Ile Ala Asp Asn Met His Leu Thr Gly Glu Gly Lys Arg Lys Val Phe 
        675                 680                 685             


Ala Ser Asn Gly Gln Ile Thr Ala Leu Leu Arg Gly Arg Trp Gly Leu 
    690                 695                 700                 


Ala Lys Ser Arg Glu Asp Asn Asp Arg His His Ala Leu Asp Ala Val 
705                 710                 715                 720 


Val Val Ala Cys Ser Thr Val Ser Met Gln Gln Lys Ile Thr Arg Phe 
                725                 730                 735     


Val Arg Phe Glu Glu Gly Asn Val Phe Thr Gly Glu Arg Ile Asp Arg 
            740                 745                 750         


Glu Thr Gly Glu Ile Ile Pro Leu His Phe Pro Ala Pro Trp Lys Phe 
        755                 760                 765             


Phe Arg Glu Glu Val Glu Ile Arg Ile Phe Ser Asp Asn Pro Lys Leu 
    770                 775                 780                 


Glu Leu Glu Asn Arg Leu Ile Ala Arg Pro Gln Ala Asn His Glu Phe 
785                 790                 795                 800 


Val Gln Pro Leu Phe Val Ser Arg Met Pro Thr Arg Lys Met Ile Gly 
                805                 810                 815     


Gln Gly His Met Glu Thr Ile Lys Ser Ala Lys Arg Leu Asn Glu Gly 
            820                 825                 830         


Leu Ser Val Ile Lys Met Leu Leu Thr Lys Leu Arg Leu Lys Asp Leu 
        835                 840                 845             


Glu Ser Met Val Asn Arg Glu Arg Glu Lys Glu Leu Tyr Glu Ala Leu 
    850                 855                 860                 


Lys Ala Arg Leu Glu Ala Phe Asn Asp Glu Pro Ala Lys Ala Phe Ala 
865                 870                 875                 880 


Glu Pro Phe Met Lys Lys Gly Gly Ala Ile Val Lys Ser Val Arg Val 
                885                 890                 895     


Glu Gln Val Gln Lys Ser Gly Val Leu Val Arg Asp Gly Asn Gly Val 
            900                 905                 910         


Ala Asp Asn Ala Ser Met Val Arg Val Asp Val Phe Thr Lys Gly Gly 
        915                 920                 925             


Lys Tyr Phe Leu Val Pro Ile Tyr Thr Trp Gln Val Ala Lys Gly Ile 
    930                 935                 940                 


Leu Pro Asn Lys Ala Val Ile Gln Gly Lys Asn Glu Glu Asp Trp Glu 
945                 950                 955                 960 


Val Met Asp Asp Ala Thr Phe Arg Phe Ser Leu His Gln Asn Asp Leu 
                965                 970                 975     


Val Lys Leu Val Thr Lys Lys Lys Thr Ile Phe Gly Tyr Phe Asn Gly 
            980                 985                 990         


Leu Asn Arg Ala Thr Gly Asn Ile  Asp Ile Lys Glu His  Asp Leu Glu 
        995                 1000                 1005             


Lys Ser  Lys Val Lys Asp Gly  Ile His Gln Ser Ile  Gly Ile Lys 
    1010                 1015                 1020             


Leu Ala  Leu Ser Phe Glu Lys  Tyr Gln Val Asp Glu  Leu Gly Lys 
    1025                 1030                 1035             


Asn Ile  Arg Leu Cys Lys Ser  Ser Lys Arg Gln Ala  Val Arg 
    1040                 1045                 1050         


<210> 250
<211> 1052
<212> PRT
<213> Haemophilus parainfluenzae

<400> 250
Met Glu Asn Lys Asn Leu His Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Val Val Glu Ile Asp Glu Lys Glu Asn Pro 
            20                  25                  30          


Leu Arg Leu Ile Asp Val Gly Val Arg Thr Phe Glu Arg Ala Glu Thr 
        35                  40                  45              


Gln Lys Gly Glu Ser Leu Ala Leu Ser Arg Arg Ser Ala Arg Ser Ala 
    50                  55                  60                  


Arg Arg Leu Thr Gln Arg Arg Val Ala Arg Leu Lys Lys Ala Lys Arg 
65                  70                  75                  80  


Leu Leu Lys Ser Glu Asn Ile Leu Leu Ser Thr Asp Glu Arg Leu Pro 
                85                  90                  95      


His Gln Val Trp Gln Leu Arg Val Glu Gly Leu Asp Arg Lys Leu Glu 
            100                 105                 110         


Arg Gln Glu Trp Ala Ala Val Leu Leu His Leu Ile Lys His Arg Gly 
        115                 120                 125             


Tyr Leu Ser Gln Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu Leu 
    130                 135                 140                 


Gly Ala Leu Leu Ser Gly Val Ala Ser Asn His Glu Leu Leu Gln Gln 
145                 150                 155                 160 


Ala Thr Tyr Arg Thr Pro Ala Glu Leu Ala Val Lys Lys Phe Glu Val 
                165                 170                 175     


Glu Glu Gly His Ile Arg Asn Gln Gln Gly Ala Tyr Thr His Thr Phe 
            180                 185                 190         


Ser Arg Leu Asp Leu Leu Ala Glu Met Glu Leu Leu Phe Ser Arg Gln 
        195                 200                 205             


Gln His Phe Gly Asn Pro Phe Ala Ser Glu Lys Leu Leu Glu Asn Leu 
    210                 215                 220                 


Thr Ala Leu Leu Met Trp Gln Lys Pro Ala Leu Ser Gly Glu Asp Ile 
225                 230                 235                 240 


Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Asp Glu Tyr Lys Ala Ala 
                245                 250                 255     


Lys Asn Thr Tyr Thr Ala Glu Arg Phe Val Trp Ile Thr Lys Leu Asn 
            260                 265                 270         


Asn Leu Arg Ile Gln Glu Asn Gly Leu Glu Arg Ala Leu Ser Asp Asn 
        275                 280                 285             


Glu Arg Leu Met Leu Ile Glu Gln Pro Tyr Glu Lys Ala Lys Leu Thr 
    290                 295                 300                 


Tyr Ala Gln Val Arg Ser Ile Leu Asn Leu Ser Asp Asp Ala Ile Phe 
305                 310                 315                 320 


Lys Gly Val Arg Tyr Ser Gly Glu Asp Lys Lys Ala Ile Glu Thr Lys 
                325                 330                 335     


Thr Thr Leu Met Glu Met Lys Ala Tyr His Gln Ile Arg Lys Val Leu 
            340                 345                 350         


Glu Gly Asn Asn Leu Lys Ala Glu Trp Val Ala Leu Lys Ala Asn Pro 
        355                 360                 365             


Thr Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp 
    370                 375                 380                 


Glu Asp Ile Ser Ala Tyr Leu Ala Gly Lys Leu Ser Gln Pro Val Leu 
385                 390                 395                 400 


Asn Ala Leu Leu Glu Asn Leu Ser Phe Asp Lys Phe Ile Gln Leu Ser 
                405                 410                 415     


Leu Lys Ala Leu Tyr Lys Leu Leu Pro Leu Met Gln Gln Gly Leu Arg 
            420                 425                 430         


Tyr Asp Glu Ala Cys Arg Glu Ile Tyr Gly Asp His Tyr Gly Lys Lys 
        435                 440                 445             


Thr Glu Glu Thr His His Phe Leu Pro Gln Ile Pro Ala Asp Glu Ile 
    450                 455                 460                 


Arg Asn Pro Val Val Leu Arg Thr Leu Thr Gln Ala Arg Lys Val Ile 
465                 470                 475                 480 


Asn Gly Val Val Arg Leu Tyr Gly Ser Pro Ala Arg Ile His Ile Glu 
                485                 490                 495     


Thr Gly Arg Glu Val Gly Lys Ser Tyr Lys Asp Arg His Glu Leu Lys 
            500                 505                 510         


Lys Arg Gln Glu Glu Asn Arg Lys Gln Arg Glu Lys Thr Ile Ser Glu 
        515                 520                 525             


Ile Lys Thr Leu Phe Pro Asn Phe Ser Gly Glu Pro Lys Gly Lys Asp 
    530                 535                 540                 


Ile Leu Lys Met Arg Leu Tyr Tyr Gln Gln Asn Ala Lys Cys Leu Tyr 
545                 550                 555                 560 


Ser Gly Lys Pro Leu Glu Leu His Arg Leu Phe Glu Gln Lys Tyr Val 
                565                 570                 575     


Glu Val Asp His Ala Leu Pro Leu Ser Arg Thr Trp Asp Asp Ser Phe 
            580                 585                 590         


Asn Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gln Asn Lys Gly Asn 
        595                 600                 605             


Leu Thr Pro Phe Glu Trp Leu Asp Gly Lys Asn Asn Ser Glu Arg Trp 
    610                 615                 620                 


Arg Thr Phe Lys Ala Leu Val Glu Thr Ser Ala Phe Pro Tyr Ala Lys 
625                 630                 635                 640 


Lys Gln Arg Ile Leu Ser Gln Lys Leu Asp Glu Lys Gly Phe Ile Glu 
                645                 650                 655     


Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys Asn Phe 
            660                 665                 670         


Ile Ala Asp Asn Met His Leu Thr Gly Glu Gly Lys Arg Lys Val Phe 
        675                 680                 685             


Ala Ser Asn Gly Gln Ile Thr Ala Leu Leu Arg Arg Arg Trp Gly Leu 
    690                 695                 700                 


Ala Lys Ser Arg Glu Asp Asn Asp Arg His His Ala Leu Asp Ala Val 
705                 710                 715                 720 


Leu Val Ala Cys Ser Thr Val Ala Met Gln Gln Lys Ile Thr Arg Phe 
                725                 730                 735     


Val Arg Phe Lys Ala Gly Asp Val Phe Thr Gly Glu Arg Ile Asp Arg 
            740                 745                 750         


Glu Thr Gly Glu Ile Ile Pro Leu His Phe Pro Thr Pro Trp Gln Phe 
        755                 760                 765             


Phe Lys Gln Glu Val Glu Ile Arg Ile Phe Ser Asp Asn Pro Lys Leu 
    770                 775                 780                 


Glu Leu Glu Asn Arg Leu Pro Asp Arg Pro Gln Ala Asn His Glu Phe 
785                 790                 795                 800 


Val Gln Pro Leu Phe Val Ser Arg Met Pro Thr Arg Lys Met Thr Gly 
                805                 810                 815     


Gln Gly His Met Glu Thr Val Lys Ser Ala Lys Arg Leu Asn Glu Gly 
            820                 825                 830         


Ile Ser Met Ile Lys Met Pro Leu Thr Lys Leu Lys Leu Lys Asp Leu 
        835                 840                 845             


Glu Leu Met Val Asn Arg Glu Arg Glu Lys Asp Leu Tyr Asp Ala Leu 
    850                 855                 860                 


Lys Thr Arg Leu Glu Ala Phe Asn Asp Asp Pro Ala Lys Ala Phe Ala 
865                 870                 875                 880 


Glu Pro Phe Met Lys Lys Gly Gly Ala Ile Val Lys Ser Val Arg Val 
                885                 890                 895     


Glu Gln Val Gln Lys Ser Gly Val Leu Val Arg Gln Gly Asn Gly Val 
            900                 905                 910         


Ala Asp Asn Ala Ser Met Val Arg Val Asp Val Phe Thr Lys Asp Gly 
        915                 920                 925             


Lys Tyr Phe Leu Val Pro Ile Tyr Thr Trp Gln Val Ala Lys Gly Ile 
    930                 935                 940                 


Leu Pro Asn Lys Ala Val Ile Gln Gly Lys Asp Glu Glu Asp Trp Glu 
945                 950                 955                 960 


Asp Ile Asp Asp Ala Thr Phe Gln Phe Ser Leu His Pro Asn Asp Leu 
                965                 970                 975     


Ile Ser Val Lys Thr Lys Lys Asp Glu Phe Leu Gly Tyr Phe Asn Gly 
            980                 985                 990         


Leu Asn Arg His Thr Gly Gly Ile  Asn Ile Arg Thr His  Asp Leu Glu 
        995                 1000                 1005             


Lys Ser  Lys Gly Lys Gln Gly  Ile Phe Glu Gly Ile  Gly Val Lys 
    1010                 1015                 1020             


Ile Ala  Leu Ser Phe Glu Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1025                 1030                 1035             


Asn Ile  Arg Leu Cys Lys Pro  Ser Lys Arg Gln Pro  Val Arg 
    1040                 1045                 1050         


<210> 251
<211> 1052
<212> PRT
<213> Haemophilus sputorum


<220>
<223> Haemophilus sputorum HK 2154

<400> 251
Met Lys Asn Thr Ser Leu Asn Tyr Val Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ser Ser Val Gly Trp Ala Val Val Glu Ile Asp Glu Lys Glu Asn Pro 
            20                  25                  30          


Leu Ser Leu Ile Asp Val Gly Val Arg Thr Phe Glu Arg Ala Glu Thr 
        35                  40                  45              


Gln Lys Gly Glu Ser Leu Ala Leu Ala Arg Arg Leu Ala Arg Ser Ala 
    50                  55                  60                  


Arg Arg Leu Thr Gln Arg Arg Val Ala Arg Leu Lys Lys Ala Lys Arg 
65                  70                  75                  80  


Leu Leu Lys Ser Glu Asn Ile Leu Leu Ser Thr Asp Glu Cys Leu Pro 
                85                  90                  95      


His Gln Val Trp Gln Leu Arg Val Glu Gly Leu Glu Arg Lys Leu Glu 
            100                 105                 110         


Arg Gln Glu Trp Ala Ala Val Leu Leu His Leu Ile Lys His Arg Gly 
        115                 120                 125             


Tyr Leu Ser Gln Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu Leu 
    130                 135                 140                 


Gly Ala Leu Leu Ser Gly Val Ala Asn Asn His Lys Leu Leu Gln Gln 
145                 150                 155                 160 


Thr Thr Tyr Arg Thr Pro Ala Glu Leu Ala Val Lys Lys Phe Glu Val 
                165                 170                 175     


Glu Glu Gly His Ile Arg Asn Gln Gln Gly Ser Tyr Thr His Thr Phe 
            180                 185                 190         


Ser Arg Leu Asp Leu Leu Ser Glu Met Glu Leu Leu Phe Ser Arg Gln 
        195                 200                 205             


Gln His Phe Gly Asn Pro Phe Thr Ser Glu Lys Leu Leu Glu Asn Leu 
    210                 215                 220                 


Thr Ala Leu Leu Met Trp Gln Lys Pro Ala Leu Ser Gly Asp Ala Ile 
225                 230                 235                 240 


Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Asn Glu Tyr Lys Ala Ala 
                245                 250                 255     


Lys His Thr Tyr Ser Ala Glu Arg Phe Ile Trp Ile Thr Lys Leu Asn 
            260                 265                 270         


Asn Leu Arg Ile Gln Glu Asn Gly Leu Glu Arg Ala Leu Asn Asp Asn 
        275                 280                 285             


Glu Arg Leu Ala Leu Met Lys Gln Pro Tyr Glu Lys Ala Lys Leu Thr 
    290                 295                 300                 


Tyr Ala Gln Val Arg Ser Ile Leu Asn Leu Ser Asp Glu Ala Ile Phe 
305                 310                 315                 320 


Lys Gly Leu Arg Tyr Ser Gly Glu Asp Lys Lys Thr Ser Glu Thr Lys 
                325                 330                 335     


Thr Val Leu Met Glu Met Lys Ala Tyr His Gln Ile Arg Leu Ala Leu 
            340                 345                 350         


Glu Lys Asn Asp Leu Lys Thr Glu Trp Ala Glu Leu Lys Val Asn Ser 
        355                 360                 365             


Ser Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp 
    370                 375                 380                 


Glu Asp Ile Ser Thr Cys Leu Ala Gly Lys Leu Ser Gln Pro Val Leu 
385                 390                 395                 400 


Asn Ala Leu Leu Glu Asn Leu Asn Phe Asp Lys Phe Ile Gln Leu Ser 
                405                 410                 415     


Leu Lys Ala Leu His Lys Ile Leu Pro Leu Met Gln Gln Gly Leu Arg 
            420                 425                 430         


Tyr Asp Glu Ala Cys Ala Glu Ile Tyr Gly Asp His Tyr Gly Lys Lys 
        435                 440                 445             


Thr Glu Glu Asn His Leu Leu Leu Pro Gln Ile Pro Ala Asp Glu Ile 
    450                 455                 460                 


Arg Asn Pro Val Val Leu Arg Thr Leu Thr Gln Ala Arg Lys Val Ile 
465                 470                 475                 480 


Asn Gly Val Val Arg Leu Tyr Ser Ser Pro Ala Arg Ile His Ile Glu 
                485                 490                 495     


Thr Gly Arg Glu Val Gly Lys Ser Tyr Gln Asp Arg Arg Glu Leu Glu 
            500                 505                 510         


Lys Arg Gln Glu Glu Asn Arg Lys Gln Arg Glu Lys Ala Ile Ser Glu 
        515                 520                 525             


Ile Lys Thr Leu Phe Pro Asn Phe Ser Gly Glu Pro Lys Ala Lys Asp 
    530                 535                 540                 


Ile Leu Lys Met Arg Leu Tyr Tyr Gln Gln Asn Ala Lys Cys Leu Tyr 
545                 550                 555                 560 


Ser Gly Lys Pro Leu Glu Leu His Arg Leu Leu Glu Gln Gly Tyr Val 
                565                 570                 575     


Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe 
            580                 585                 590         


Asn Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gln Asn Lys Gly Asn 
        595                 600                 605             


Leu Thr Pro Phe Glu Trp Leu Asp Gly Lys Asn Asn Ser Glu Arg Trp 
    610                 615                 620                 


Lys Ala Phe Lys Ala Leu Val Glu Thr Ser Ala Phe Pro Tyr Thr Lys 
625                 630                 635                 640 


Lys Gln Arg Ile Leu Ser Gln Lys Leu Asp Glu Lys Gly Phe Ile Glu 
                645                 650                 655     


Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys Asn Phe 
            660                 665                 670         


Ile Ala Asp Asn Met His Leu Thr Gly Glu Gly Lys Arg Lys Val Phe 
        675                 680                 685             


Ala Ser Asn Gly Gln Ile Thr Ala Leu Leu Arg Gly Arg Trp Gly Leu 
    690                 695                 700                 


Ala Lys Ser Arg Glu Asp Asn Asp Arg His His Ala Leu Asp Ala Val 
705                 710                 715                 720 


Val Val Ala Cys Ser Thr Val Ser Met Gln Gln Lys Ile Thr Arg Phe 
                725                 730                 735     


Val Arg Phe Glu Glu Gly Asn Val Phe Thr Gly Glu Arg Ile Asp Arg 
            740                 745                 750         


Glu Thr Gly Glu Ile Ile Pro Leu His Phe Pro Ala Pro Trp Lys Phe 
        755                 760                 765             


Phe Arg Glu Glu Val Glu Ile Arg Ile Phe Ser Asp Asn Pro Lys Leu 
    770                 775                 780                 


Glu Leu Glu Asn Arg Leu Ile Ala Arg Pro Gln Ala Asn His Glu Phe 
785                 790                 795                 800 


Val Gln Pro Leu Phe Val Ser Arg Met Pro Thr Arg Lys Met Thr Gly 
                805                 810                 815     


Gln Gly His Met Glu Thr Ile Lys Ser Ala Lys Arg Leu Asn Glu Gly 
            820                 825                 830         


Leu Ser Val Ile Lys Met Leu Leu Thr Lys Leu Arg Leu Lys Asp Leu 
        835                 840                 845             


Glu Ser Met Val Asn Arg Glu Arg Glu Lys Glu Leu Tyr Glu Ala Leu 
    850                 855                 860                 


Lys Ala Arg Leu Glu Ala Phe Asn Asp Glu Pro Ala Lys Ala Phe Ala 
865                 870                 875                 880 


Glu Pro Phe Met Lys Lys Gly Gly Ala Ile Val Lys Ser Val Arg Val 
                885                 890                 895     


Glu Gln Val Gln Lys Ser Gly Val Leu Val Arg Asp Gly Asn Gly Val 
            900                 905                 910         


Ala Asp Asn Ala Ser Met Val Arg Val Asp Val Phe Thr Lys Gly Gly 
        915                 920                 925             


Lys Tyr Phe Leu Val Pro Ile Tyr Thr Trp Gln Val Ala Lys Gly Ile 
    930                 935                 940                 


Leu Pro Asn Lys Ala Val Ile Gln Gly Lys Asn Glu Glu Asp Trp Glu 
945                 950                 955                 960 


Val Met Asp Asp Ala Thr Phe Arg Phe Ser Leu His Gln Asn Asp Leu 
                965                 970                 975     


Val Lys Leu Val Thr Lys Lys Lys Thr Ile Phe Gly Tyr Phe Asn Gly 
            980                 985                 990         


Leu Asn Arg Ala Thr Gly Asn Ile  Asp Ile Lys Glu His  Asp Leu Glu 
        995                 1000                 1005             


Lys Ser  Lys Val Lys Asp Gly  Ile His Gln Ser Ile  Gly Ile Lys 
    1010                 1015                 1020             


Leu Ala  Leu Ser Phe Glu Lys  Tyr Gln Val Asp Glu  Leu Gly Lys 
    1025                 1030                 1035             


Asn Ile  Arg Leu Cys Lys Ser  Ser Lys Arg Gln Ala  Val Arg 
    1040                 1045                 1050         


<210> 252
<211> 1338
<212> PRT
<213> Helcococcus kunzii


<220>
<223> Helcococcus kunzii ATCC 51366

<400> 252
Met Gln Asp Tyr Tyr Leu Gly Leu Asp Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Thr Asp Glu Asn Tyr Asn Leu Leu Arg Lys Lys Gly Lys 
            20                  25                  30          


Asp Leu Trp Gly Val Arg Leu Phe Lys Glu Ala Gln Pro Ala Thr Glu 
        35                  40                  45              


Arg Arg Gly His Arg Ser Ser Arg Arg Arg Thr Ile Arg Lys Ser Leu 
    50                  55                  60                  


Arg Lys Gln Leu Leu Arg Glu Leu Phe Glu Glu Glu Ile Asn Ala Ile 
65                  70                  75                  80  


Asp Lys Asp Phe Phe Leu Arg Leu Asp Glu Ser Lys Tyr Trp Leu Glu 
                85                  90                  95      


Asp Lys Lys Ile Glu Gly Lys Tyr Ser Leu Phe Asn Asp Glu Asn Phe 
            100                 105                 110         


Thr Asp Lys Asp Tyr Tyr Glu Lys Phe Pro Thr Ile Phe His Leu Arg 
        115                 120                 125             


Lys Ala Leu Ile Glu Ser Asp Asp Lys Glu Asp Ile Arg Leu Tyr Phe 
    130                 135                 140                 


Leu Ala Ile Asn Gln Met Met Lys Arg Arg Gly His Phe Leu Ile Asp 
145                 150                 155                 160 


Gly Lys Leu Ser Asn Val Glu Asp Ile Thr Pro Phe Lys Glu Cys Ile 
                165                 170                 175     


Gln Asn Leu Ile Asn Glu Glu Leu Asp Thr Glu Ile Glu Thr Glu Phe 
            180                 185                 190         


Tyr Asp Lys Ala Ile Lys Ile Val Ser Asp Tyr Ser Leu Lys Lys Thr 
        195                 200                 205             


Glu Lys Lys Asn Leu Ile Lys Asp Leu Val Lys Glu Thr Asp Ser Ile 
    210                 215                 220                 


Glu Asp Ser Lys Lys Ile Ile Asn Ile Phe Asn Leu Leu Ile Ser Gly 
225                 230                 235                 240 


Lys Ser Lys Val Asn Gly Ile Phe Asp Asp Glu Glu Ile Leu Glu Lys 
                245                 250                 255     


Ile Lys Glu Asp Asn Lys Glu Asp Phe Tyr Leu Thr Ser Glu Lys Tyr 
            260                 265                 270         


Glu Glu Asn Leu Glu Tyr Phe Ser Gln Leu Leu Asp Tyr Arg Phe Glu 
        275                 280                 285             


Leu Ile Ser Ser Leu Lys Ser Ile Tyr Asp Tyr Ile Ile Leu Gln Glu 
    290                 295                 300                 


Val Leu Lys Gly Lys Lys Tyr Leu Ser Tyr Ala Gln Val Glu Arg Tyr 
305                 310                 315                 320 


Lys Asn His Lys Glu Asp Leu Arg Lys Leu Lys Gln Leu Ile Lys Lys 
                325                 330                 335     


Tyr Asp Lys Asn Gly Lys Ile Tyr Tyr Gln Ile Phe Arg Asp Glu Asn 
            340                 345                 350         


Phe Lys Lys Gly Tyr Val Ala Tyr Leu Gly Tyr Tyr Lys Lys Asn Lys 
        355                 360                 365             


Lys Asn Val Pro Val Lys Lys Cys Asp Tyr Asp Thr Phe Ser Lys Asn 
    370                 375                 380                 


Ile Lys Ser Thr Leu Asp Lys Ile Cys Asp Lys Glu Asp Pro Leu Tyr 
385                 390                 395                 400 


Ile Glu Leu Ile Asp Lys Ile Glu Lys Gly Gly Phe Leu Leu Lys Gln 
                405                 410                 415     


Ile Val Ser Thr Asn Ser Val Ile Pro His Gln Val His Glu Leu Glu 
            420                 425                 430         


Leu Asp Lys Ile Leu Glu Asn Leu Glu Lys Asn Tyr Pro Ser Phe Lys 
        435                 440                 445             


Glu Ile Ser Asp Gly Val Ser Lys Ile Asp Lys Ile Lys Met Ile Phe 
    450                 455                 460                 


Asn Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Asp Tyr His Lys 
465                 470                 475                 480 


Asp Lys Val Asn Ser Asn Thr Trp Ile Val Lys Asn Glu Gly Phe Glu 
                485                 490                 495     


Asn Glu Asn Ile Arg Pro Trp Asn Phe Ser Lys Ile Val Asp Glu His 
            500                 505                 510         


Ala Cys Glu Glu Glu Phe Ile Lys Arg Met Ile Asn Glu Cys Ser Tyr 
        515                 520                 525             


Ile Pro Gly Glu Lys Val Leu Pro Lys Ser Ser Leu Leu Tyr Ser Glu 
    530                 535                 540                 


Tyr Met Val Leu Asn Glu Leu Asn Asn Leu Arg Val Asn Gly Asp Lys 
545                 550                 555                 560 


Leu Asn Pro Lys Ile Lys Lys Glu Ile Val Glu Asn Ile Tyr Lys Lys 
                565                 570                 575     


Glu Arg Lys Val Thr Leu Lys Lys Ile Arg Asn Phe Leu Ile Ile Asn 
            580                 585                 590         


Asn Tyr Val Asp Ser Lys Val Glu Phe Ser Gly Leu Ser Asp Gly Ile 
        595                 600                 605             


Lys Ala Asn Met Ser Ser Tyr Ile Asp Phe Ala Glu Ile Leu Asp Asp 
    610                 615                 620                 


Asn Phe Asp Asn Asn Met Val Glu Asp Leu Ile Glu Gln Ile Thr Ile 
625                 630                 635                 640 


His Val Gly Asn Val Lys Leu Leu Thr Glu Lys Ile Ser Asn Lys Tyr 
                645                 650                 655     


Pro Asn Leu Glu Lys Lys Gln Ile Asn Lys Ile Val Asn Leu Lys Phe 
            660                 665                 670         


Lys Asp Trp Ala Arg Phe Ser Arg Lys Leu Leu Val Gly Ile Glu Gly 
        675                 680                 685             


Thr Glu Lys Glu Thr Gly Glu Ile Asn Thr Ile Ile Gly Phe Leu Arg 
    690                 695                 700                 


Glu Thr Asn Glu Asn Phe Met Glu Leu Met Ser Asn Arg Tyr Thr Phe 
705                 710                 715                 720 


Ser Glu Glu Ile Ser Glu Ile Lys Lys Lys Tyr Ile Pro Asn Lys Leu 
                725                 730                 735     


Ser Lys Gln Ile Val Asp Asp Leu Tyr Val Ser Pro Ala Val Lys Lys 
            740                 745                 750         


Met Ile Trp Gln Val Leu Asn Ile Asn Asp Glu Leu Ile Lys Val Leu 
        755                 760                 765             


Gly Lys Gln Pro Lys Lys Ile Phe Ile Glu Met Ala Arg Gly Lys Glu 
    770                 775                 780                 


Glu Lys Pro Glu Val Lys Asp Ser Arg Lys Asn Lys Leu Ile Glu Leu 
785                 790                 795                 800 


Tyr Lys Asn Leu Gly Lys Glu Gly Lys Glu Trp Leu Asn Arg Ile Glu 
                805                 810                 815     


Asp Lys Thr Glu Ala Asp Phe Arg Asn Arg Ala Leu Tyr Leu Tyr Tyr 
            820                 825                 830         


Thr Gln Met Gly Arg Cys Met Tyr Thr Gly Glu Ile Ile Asp Ile Glu 
        835                 840                 845             


Arg Leu Tyr Asp Lys Glu Leu Tyr Asp Leu Asp His Ile Ile Pro Arg 
    850                 855                 860                 


Lys Met Lys Lys Asp Asp Ser Ile His Lys Asn Leu Val Leu Val Thr 
865                 870                 875                 880 


Arg Asn Ser Asn Gln Tyr Glu Lys Lys Asp Asn Tyr Pro Val Pro Glu 
                885                 890                 895     


Val Ile Lys Ser Arg Glu Asn Val Arg His Leu Trp Tyr Ala Leu Lys 
            900                 905                 910         


Lys Lys Gly Leu Ile Thr Glu Glu Lys Tyr Asn Arg Leu Thr Arg Ile 
        915                 920                 925             


Asn Pro Leu Ser Asp Lys Glu Leu Ser Glu Phe Ile Glu Arg Gln Leu 
    930                 935                 940                 


Val Glu Thr Arg Gln Thr Thr Lys Val Val Lys Asp Leu Phe Glu Asn 
945                 950                 955                 960 


Tyr Tyr Thr Asp Ser Lys Ile Val Thr Val Lys Ala Gly Leu Val Ser 
                965                 970                 975     


Glu Leu Arg Arg Asp Phe Glu Val Leu Lys Cys Arg Glu Ile Asn Asp 
            980                 985                 990         


Leu Asn His Ala His Asp Ala Phe  Leu Asn Ile Ile Val  Gly Asp Val 
        995                 1000                 1005             


Trp Ser  Lys Lys Phe Thr Ser  Asn Pro Tyr Asn Phe  Val Lys Lys 
    1010                 1015                 1020             


Asn Arg  Glu Lys Tyr Thr Leu  Asn Asn Ile Phe Thr  Lys Asn Gln 
    1025                 1030                 1035             


Lys Asp  Leu Arg Gly Asn Glu  Ile Trp Asn Cys Ala  Glu Gly Lys 
    1040                 1045                 1050             


Lys Arg  Ile Ile Lys Thr Leu  Asn Lys Pro Ser Val  Leu Phe Ser 
    1055                 1060                 1065             


Val Glu  Asn Phe Glu Gln Thr  Gly Gln Leu Phe Asp  Gln Asn Ile 
    1070                 1075                 1080             


Ile Gly  Lys Gln Asp Tyr Lys  Glu Lys Thr Ser Tyr  Val Pro Ile 
    1085                 1090                 1095             


Lys Gly  Asp Glu Arg Leu Gln  Asp Ile Ser Lys Tyr  Gly Gly Tyr 
    1100                 1105                 1110             


Arg Gly  Ile Ser Gly Ala Tyr  Phe Phe Ile Val Glu  His Thr Glu 
    1115                 1120                 1125             


Lys Asn  Lys Arg Val Lys Thr  Ile Glu Ser Leu Pro  Ile Tyr Met 
    1130                 1135                 1140             


Lys Ser  Tyr Val Glu Glu Asn  Gly Leu Leu Asp Phe  Cys Thr Asn 
    1145                 1150                 1155             


Glu Met  Lys Leu Val Asp Pro  Lys Ile Ile Val Lys  Lys Leu Asn 
    1160                 1165                 1170             


Tyr Lys  Ser Glu Ile Ile Val  Asp Gly Phe Lys Tyr  Leu Ile Ser 
    1175                 1180                 1185             


Gly Lys  Thr Glu Asn Arg Leu  Ser Leu Glu Thr Asn  Glu Tyr Leu 
    1190                 1195                 1200             


Tyr Trp  Asn His Thr Gln Thr  Thr Asp Ile Lys Lys  Ile Leu Asn 
    1205                 1210                 1215             


Ile Asn  Glu Lys Ile Glu Leu  Glu Lys Tyr Asn Gly  Asp Ile Glu 
    1220                 1225                 1230             


Ser Glu  Arg Glu Asn Ile Ile  Lys Tyr Ile Gln Ile  Ile Leu Glu 
    1235                 1240                 1245             


Lys Phe  Lys Leu Lys Pro Phe  Ile Lys Arg Arg Asn  Leu Pro Asn 
    1250                 1255                 1260             


Ile Glu  Ile Asn Phe Ala Asp  Tyr Glu Thr Glu Lys  Leu Leu Gln 
    1265                 1270                 1275             


Leu Leu  Val Asn Leu Ile Pro  Leu Thr Thr Lys Tyr  Val Ser Pro 
    1280                 1285                 1290             


Val Asp  Leu Thr Val Ile Ser  Gly Ser Lys Tyr Ala  Gly Lys Val 
    1295                 1300                 1305             


Leu Ile  Pro Lys Lys Ile Ser  Asn Leu Asn Glu Val  Ile Phe Ile 
    1310                 1315                 1320             


Ser Lys  Ser Ile Thr Gly Ile  Tyr Glu Ser Arg Arg  Arg Ile Ile 
    1325                 1330                 1335             


<210> 253
<211> 1007
<212> PRT
<213> Helicobacter canadensis


<220>
<223> Helicobacter canadensis MIT 98-5491

<400> 253
Met Lys Val Leu Gly Phe Asp Ile Gly Ile Asn Ser Ile Gly Trp Ala 
1               5                   10                  15      


Phe Val Glu Asn Asn Glu Leu Lys Asp Cys Gly Val Arg Leu Phe Thr 
            20                  25                  30          


Lys Ala Glu Asn Pro Lys Thr Lys Glu Ser Leu Ala Leu Pro Arg Arg 
        35                  40                  45              


Asn Ala Arg Ser Ser Arg Val Arg Leu Arg Arg Arg Arg Ser Arg Leu 
    50                  55                  60                  


Leu Ser Leu Lys His Ile Ile Ser Lys Glu Phe Gly Leu His Tyr Glu 
65                  70                  75                  80  


Asp Tyr Ile Ala Leu Asp Gly Asn Leu Pro Lys Ala Tyr Thr Gly Lys 
                85                  90                  95      


Ile Glu Ser Ile Tyr Lys Leu Arg Tyr Glu Ala Leu Ser Gln Ala Ile 
            100                 105                 110         


Ser Lys Glu Asp Leu Ala Arg Val Ile Leu His Ile Ala Lys His Arg 
        115                 120                 125             


Gly Tyr Met Asn Lys Asn Gln Lys Thr Ser Gln Asp Ser Glu Lys Gly 
    130                 135                 140                 


Ala Ile Leu Ser Ala Ile Lys Glu Asn Ser Asn Lys Ile Lys His Tyr 
145                 150                 155                 160 


Gln Thr Ala Gly Glu Tyr Phe Tyr Lys Glu Leu Phe Glu Asn Leu Arg 
                165                 170                 175     


Asp Gly Thr Lys Glu Phe Lys Asn Ile Arg Asn Lys Ala Met Lys Asn 
            180                 185                 190         


Glu Lys Thr Gly Asn Met Glu Ser Thr Tyr Tyr Asn Thr Ile Leu Ala 
        195                 200                 205             


Ser Asp Leu Glu Lys Glu Leu Lys Leu Ile Leu Glu Lys Gln Gln Ala 
    210                 215                 220                 


Tyr His Asn Tyr Ser Asp Thr Phe Ile Lys Glu Val Leu Glu Ile Ala 
225                 230                 235                 240 


Phe Tyr Gln Arg Pro Leu Lys Asp Phe Ser His Leu Val Gly Ser Cys 
                245                 250                 255     


Thr Phe Tyr Glu Asn Glu Lys Arg Ala Cys Lys Asn Ser Tyr Ser Ala 
            260                 265                 270         


Trp Glu Phe Ile Ala Leu Gly Lys Ile Ile Asn Thr Leu Glu Ser Ile 
        275                 280                 285             


Lys Lys Asp Thr Gly Glu Ile Phe Ser Asn Glu Ile Ile Thr Gln Ile 
    290                 295                 300                 


Leu Lys Glu Val Leu Asp Lys Gly Ser Leu Ser Tyr Thr Lys Leu Arg 
305                 310                 315                 320 


Lys Met Ile Asn Leu Asp Glu Lys Val Lys Phe Lys Gly Leu Lys Tyr 
                325                 330                 335     


Asp Lys Glu Gly Val Glu Lys Thr Asn Leu Ile Glu Phe Lys Lys Leu 
            340                 345                 350         


Lys Glu Phe Lys Lys Ala Leu Gly Glu His Asn Leu Glu Arg Lys Thr 
        355                 360                 365             


Leu Asp Glu Ile Ala Thr His Ile Thr Leu Thr Lys Asp Glu Asn Gln 
    370                 375                 380                 


Leu Lys Lys Gln Leu Glu Gln Tyr Ala Leu Ser Gln Asn Gln Ile Asp 
385                 390                 395                 400 


Ala Leu Ala Glu Leu Asp Phe Asn Asp His Ile Asn Leu Ser Phe Lys 
                405                 410                 415     


Ala Leu Tyr Glu Ile Leu Pro Leu Met Glu Lys Gly Lys Arg Tyr Asp 
            420                 425                 430         


Glu Ala Cys Asn Glu Leu Gly Leu Lys Ala Lys Thr Ser Asn Gln Lys 
        435                 440                 445             


Ser Glu Phe Leu Pro Ala Phe Cys Asp Ser Ile Phe Ala Gln Glu Leu 
    450                 455                 460                 


Thr Asn Pro Ile Val Asn Arg Ala Ile Ser Glu Tyr Arg Lys Val Leu 
465                 470                 475                 480 


Asn Arg Leu Leu Lys Lys Tyr Gly Lys Met His Lys Ile His Ile Glu 
                485                 490                 495     


Leu Ala Arg Asp Ala Gly Leu Ser Lys Glu Ala Arg Asn Lys Ile Glu 
            500                 505                 510         


Lys Glu Gln Lys Glu Asn Lys Asp Ile Asn Asp Lys Ala Glu Lys Thr 
        515                 520                 525             


Cys Lys Glu Phe Gly Leu Lys Pro Asn Ala Lys Asn Ile Leu Lys Ile 
    530                 535                 540                 


Lys Leu Trp Arg Glu Gln Gly Glu Ile Cys Ala Tyr Ser Gly Lys Lys 
545                 550                 555                 560 


Ile Thr Ile Asp Asp Leu Lys Glu Asp Lys Ala Leu Glu Val Asp His 
                565                 570                 575     


Ile Tyr Pro Tyr Ser Arg Ser Tyr Asp Asp Ser Tyr Asn Asn Lys Val 
            580                 585                 590         


Leu Val Phe Ile Lys Glu Asn Gln Leu Lys Leu Asn Gln Thr Pro Tyr 
        595                 600                 605             


Glu Ala Phe Gly Ser Asn Gln Glu Lys Trp Ser Lys Ile Gln Val Leu 
    610                 615                 620                 


Ala Gln Lys Leu Pro Tyr Lys Lys Lys Asn Arg Ile Leu Asp Glu Asn 
625                 630                 635                 640 


Phe Lys Asn Lys Asp Gln Ile Glu Phe Ile Ser Arg Asn Leu Asn Asp 
                645                 650                 655     


Thr Arg Tyr Ala Thr Ser Leu Ile Ala Lys Tyr Thr Lys Glu Tyr Leu 
            660                 665                 670         


Glu Phe Leu Pro Leu Ser Asp Asp Glu Asp Ile Ser Leu Lys Ser Gly 
        675                 680                 685             


Glu Lys Gly Ser Lys Thr His Val Gln Thr Met Asn Gly Met Leu Thr 
    690                 695                 700                 


Ser Val Leu Arg His Ala Trp Gly Phe Ser Gln Lys Asp Arg Asn Asn 
705                 710                 715                 720 


His Leu His His Ala Leu Asp Ala Ile Ile Ile Ala Tyr Ser Thr Asn 
                725                 730                 735     


Ser Ile Ile Lys Ala Phe Ser Asp Phe Lys Lys Asn Gln Glu Ile Leu 
            740                 745                 750         


Lys Ala Lys Leu Tyr Ala Lys Lys Leu Thr Ser Glu Glu Tyr Lys Asn 
        755                 760                 765             


Gln Ser Lys Phe Thr Gly Phe Glu Lys Tyr Arg Ser Lys Ile Leu Glu 
    770                 775                 780                 


Lys Leu Asp Ser Ile Phe Val Ser Lys Pro Pro Asn Lys Asn Thr Lys 
785                 790                 795                 800 


Gly Ala Leu His Glu Gln Thr Phe Tyr Ser Tyr Gln Asp Ile Leu Glu 
                805                 810                 815     


Glu Tyr Lys Thr Gln Glu Gly Leu Lys Arg Ala Leu Glu Cys Gly Lys 
            820                 825                 830         


Val Arg Lys Ile Gly Thr Lys Tyr Val Val Asn Asp Arg Met Val Arg 
        835                 840                 845             


Leu Asp Ile Phe Lys Lys Asp Asn Lys Phe Tyr Gly Ile Pro Ile Tyr 
    850                 855                 860                 


Thr Met Asp Phe Ala Leu Gly Val Leu Pro Asn Lys Val Val Thr Ile 
865                 870                 875                 880 


Gly Thr Asp Lys Asp Lys Ile Lys Lys Glu Trp Lys Thr Ile Asp Glu 
                885                 890                 895     


Thr Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Gly Asp Leu Val Leu Ile 
            900                 905                 910         


Gln Lys Lys Glu Met Gln Glu Ser Glu Phe Ala Tyr Tyr Asn Gly Phe 
        915                 920                 925             


Asp Ile Ser Ser Ala Ser Ile Ser Leu Glu Lys His Asp Asn Lys Phe 
    930                 935                 940                 


Glu Asn Leu Thr Glu Asn Gln Lys Leu Leu Phe Pro Lys Ala Lys Glu 
945                 950                 955                 960 


Gly Asp Val Glu Val Arg Gly Ile Gly Ile Gln Gly Leu Lys Val Phe 
                965                 970                 975     


Lys Lys Tyr Met Val Thr Pro Leu Gly Glu Ile Gln Glu Thr Arg Thr 
            980                 985                 990         


Glu Ala Arg Gln Asn Ile Gln Pro  Arg Lys Lys His Gly  Leu Arg 
        995                 1000                 1005         


<210> 254
<211> 1023
<212> PRT
<213> Helicobacter cinaedi


<220>
<223> Helicobacter cinaedi CCUG 18818 = ATCC BAA-847

<400> 254
Met Lys Ile Tyr Ser Phe Asp Ile Gly Val Ala Ser Ile Gly Trp Ala 
1               5                   10                  15      


Phe Ile Glu Asn Glu Val Leu Gln Asp Cys Gly Ile Arg Ile Phe Thr 
            20                  25                  30          


Lys Ala Glu Asn Pro Lys Asn Gly Ala Ser Leu Ala Leu Pro Arg Arg 
        35                  40                  45              


Glu Ala Arg Gly Val Arg Lys Arg Leu Ala Arg Arg Arg Gly Arg Leu 
    50                  55                  60                  


Asn Thr Ile Lys Gln Leu Leu Cys Lys Glu Phe Gly Leu Gln Leu Glu 
65                  70                  75                  80  


Asp Tyr Leu Ser Asn Asp Gly Glu Leu Pro Lys Ala Tyr Thr Ala Ser 
                85                  90                  95      


Lys Ala Asn Pro Leu Lys Ser Pro Tyr Glu Leu Arg Thr Leu Ala Leu 
            100                 105                 110         


Ser Gln Lys Leu Asp Ser Lys Asp Leu Val Arg Val Ile Leu His Ile 
        115                 120                 125             


Ala Lys His Arg Gly Tyr Gly Asn Lys His Ala Lys Asp Ser Lys Asp 
    130                 135                 140                 


Thr Glu Ser Gly Lys Val Lys Lys Ala Ile Glu Phe Asn Arg Lys Thr 
145                 150                 155                 160 


Leu Ala Glu Lys Gly Tyr Arg Ser Val Gly Glu Tyr Leu Tyr Arg Glu 
                165                 170                 175     


Phe Phe Gln Gln Ser Arg Ile Ser Gln Asn Asn Gly Ala Thr Glu Phe 
            180                 185                 190         


Ile Asn Val Arg Asn Lys Ala Gly Asn Tyr Glu His Cys Val Ala Gln 
        195                 200                 205             


Asp Met Leu Lys Glu Glu Leu Glu Ser Ile Leu Asn Ala Gln Arg Gln 
    210                 215                 220                 


Phe Gly Phe Ser Leu Lys Gln Asp Phe Glu Ser Lys Leu Leu Thr Lys 
225                 230                 235                 240 


Ile Phe Glu Gln Arg Pro Leu Lys Ser Phe Ala Asp Lys Val Gly Asn 
                245                 250                 255     


Cys Cys Phe Ile Ala Gly Glu Lys Arg Ala Pro Lys Asp Ser Pro Ser 
            260                 265                 270         


Ala Ile Glu Phe Ile Ala Leu Ser Arg Thr Ile Asn Thr Leu Ile Asn 
        275                 280                 285             


Leu Ser Lys Glu Ser Gly Glu Ile Tyr Asn Arg Ala Ile Ile Leu Gln 
    290                 295                 300                 


Ile Val Glu Ser Thr Leu Lys Lys Gly Glu Ile Ser Tyr Lys Glu Leu 
305                 310                 315                 320 


Arg Glu Ile Ile Arg Leu Asp Glu Arg Leu Arg Phe Lys Asp Pro Arg 
                325                 330                 335     


Leu Asp Tyr Ser Arg Glu Ile Lys Glu Ala Glu Lys Val Lys Phe Leu 
            340                 345                 350         


Glu Phe Lys Gln Leu Lys Gly Phe Lys Lys Ala Leu Gly Glu Ser Phe 
        355                 360                 365             


Thr Thr Leu Ala Ile Ser Gln Leu Asp Glu Ile Ala Glu His Ile Ala 
    370                 375                 380                 


Leu Ile Lys Asp Arg Val Lys Leu Asn Glu Lys Leu Glu Ser Tyr Ala 
385                 390                 395                 400 


Leu Thr Lys Glu Gln Arg Glu Ala Leu Ser Asn Leu Ser Phe Ser Ala 
                405                 410                 415     


His Ile Asn Leu Ser Leu Gln Ala Leu Lys Gln Ile Leu Pro Phe Met 
            420                 425                 430         


Arg Gly Asp Asn Gly Glu Gln Cys Leu Asp Tyr Asp Glu Ser Val Glu 
        435                 440                 445             


Lys Ala Gly Leu Lys Ala Leu Ser Lys Asp Thr Leu Lys Gly Gln Met 
    450                 455                 460                 


Leu Pro Pro Leu Asn Glu Phe Glu Pro Tyr Leu Ser Asn Pro Val Val 
465                 470                 475                 480 


Ala Arg Ala Leu Ala Glu Tyr Arg Lys Val Leu Asn Val Leu Leu Lys 
                485                 490                 495     


Gln Tyr Gly Ser Pro His Lys Ile His Ile Glu Tyr Ala Arg Glu Ala 
            500                 505                 510         


Lys Leu Ser Ser Thr Glu Arg Gln Lys Tyr Glu Lys Glu Gln Lys Asp 
        515                 520                 525             


Asn Tyr Ala Ala Asn Gln Ala Ala His Lys Lys Cys Gln Glu Leu Gly 
    530                 535                 540                 


Leu Glu Pro Ser Ser Thr Asn Leu Leu Lys Leu Lys Leu Trp Gln Glu 
545                 550                 555                 560 


Gln Gly Gly Leu Cys Leu Tyr Ser Gly Ala Lys Ile Thr Ile Ser Tyr 
                565                 570                 575     


Leu Gln Asp Pro Thr Ala Leu Gln Val Asp His Ile Tyr Pro Tyr Ser 
            580                 585                 590         


Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Cys Leu Val Leu Thr Lys 
        595                 600                 605             


Ala Asn Gln Glu Lys Gly Asn Arg Thr Pro Phe Glu Ala Phe Gly Thr 
    610                 615                 620                 


Asp Ser Ala Lys Trp Gly Val Ile Thr Thr Leu Ala Gln Lys Leu Pro 
625                 630                 635                 640 


His Lys Lys Arg Arg Arg Ile Leu Asn Thr Ala Phe Asn Asp Lys Glu 
                645                 650                 655     


Ala Gly Phe Lys Leu Arg Asn Leu Asn Asp Thr Ser Tyr Ile Ala Arg 
            660                 665                 670         


Leu Val Ala Asp Tyr Thr Glu Thr Tyr Leu Glu Phe Leu Pro Leu Val 
        675                 680                 685             


Glu Ser Glu Asn Thr Thr Leu Ser Lys Gly Gln Lys Gly Ser Lys Lys 
    690                 695                 700                 


His Ile Ala Ile Val Asn Gly Val Leu Thr Ser Thr Met Arg Tyr Tyr 
705                 710                 715                 720 


Leu Gly Phe Ala Ser Lys Asp Arg Asp Asn His Leu His His Ala Leu 
                725                 730                 735     


Asp Ala Val Ile Ile Gly Phe Met Asn Asp Ser Val Ile Lys Ala Phe 
            740                 745                 750         


Ser Asp Phe Lys Lys Thr Gln Glu Thr Ser Lys Ala Ala Tyr Tyr Ala 
        755                 760                 765             


His Thr Leu Ser Lys Gln Glu Tyr Lys Lys Gln Arg Ala Phe Ile Gln 
    770                 775                 780                 


Leu Pro Ser Gly Glu Asn Phe Arg Val Ser Val Leu Glu Lys Val Glu 
785                 790                 795                 800 


Ser Val Phe Val Ser Lys Pro Pro Arg Lys Arg Val Arg Gly Ala Leu 
                805                 810                 815     


His Glu Ala Thr Phe Tyr Ser Pro Asn Asp Pro Lys Leu Leu Lys Asn 
            820                 825                 830         


Tyr Gly Gly Thr Lys Gly Val Glu Arg Ala Leu Ala Leu Gly Lys Met 
        835                 840                 845             


Arg Lys Val Gly Ala Lys Ile Val Ser Asn Gly Ala Met Val Arg Val 
    850                 855                 860                 


Asp Ile Phe Arg His Lys Ser Ser Gly Lys Phe Tyr Gly Val Pro Val 
865                 870                 875                 880 


Tyr Thr Met Asp Phe Ala Leu Gly Ile Leu Pro Asn Lys Ala Val Val 
                885                 890                 895     


Val Gly Lys Asp Gln Asn Gly Val Ile Lys Asp Trp Leu Glu Met Asp 
            900                 905                 910         


Ser Ser Tyr Glu Phe Ile Phe Ser Leu Tyr Lys Asp Asp Val Ile Leu 
        915                 920                 925             


Val Gln Lys Lys Glu Met Gln Arg Pro Glu Leu Cys Tyr Phe Val Ser 
    930                 935                 940                 


Phe Asp Thr Ser Gly Ala Ser Ile Lys Val Ala Lys His Asp Asn Asn 
945                 950                 955                 960 


Phe Ser Thr Leu Thr Glu Asn Gln Lys Leu Leu Phe Ser Asn Ala Thr 
                965                 970                 975     


Lys Glu Glu Val Val Gly Lys Ser Ile Gly Ile Gln Asn Leu Lys Val 
            980                 985                 990         


Phe Glu Lys Trp Gln Val Ser Val  Leu Gly Glu Val Lys  Arg Thr Gln 
        995                 1000                 1005             


Ser Tyr  Pro Arg Glu Asn Ile  Ser Leu Ala Ser Lys  Ala Lys Lys 
    1010                 1015                 1020             


<210> 255
<211> 1023
<212> PRT
<213> Helicobacter cinaedi


<220>
<223> Helicobacter cinaedi CCUG 18818

<400> 255
Met Lys Ile Tyr Ser Phe Asp Ile Gly Val Ala Ser Ile Gly Trp Ala 
1               5                   10                  15      


Phe Ile Glu Asn Glu Val Leu Gln Asp Cys Gly Ile Arg Ile Phe Thr 
            20                  25                  30          


Lys Ala Glu Asn Pro Lys Asn Gly Ala Ser Leu Ala Leu Pro Arg Arg 
        35                  40                  45              


Glu Ala Arg Gly Val Arg Lys Arg Leu Ala Arg Arg Arg Gly Arg Leu 
    50                  55                  60                  


Asn Thr Ile Lys Gln Leu Leu Cys Lys Glu Phe Gly Leu Gln Leu Glu 
65                  70                  75                  80  


Asp Tyr Leu Ser Asn Asp Gly Glu Leu Pro Lys Ala Tyr Thr Ala Ser 
                85                  90                  95      


Lys Ala Asn Pro Leu Lys Ser Pro Tyr Glu Leu Arg Thr Leu Ala Leu 
            100                 105                 110         


Ser Gln Lys Leu Asp Ser Lys Asp Leu Val Arg Val Ile Leu His Ile 
        115                 120                 125             


Ala Lys His Arg Gly Tyr Gly Asn Lys His Ala Lys Asp Ser Lys Asp 
    130                 135                 140                 


Thr Glu Ser Gly Lys Val Lys Lys Ala Ile Glu Phe Asn Arg Lys Thr 
145                 150                 155                 160 


Leu Ala Glu Lys Gly Tyr Arg Ser Val Gly Glu Tyr Leu Tyr Arg Glu 
                165                 170                 175     


Phe Phe Gln Gln Ser Arg Ile Ser Gln Asn Asn Gly Ala Thr Glu Phe 
            180                 185                 190         


Ile Asn Val Arg Asn Lys Ala Gly Asn Tyr Glu His Cys Val Ala Gln 
        195                 200                 205             


Asp Met Leu Lys Glu Glu Leu Glu Ser Ile Leu Asn Ala Gln Arg Gln 
    210                 215                 220                 


Phe Gly Phe Ser Leu Lys Gln Asp Phe Glu Asn Lys Leu Leu Thr Lys 
225                 230                 235                 240 


Ile Phe Glu Gln Arg Pro Leu Lys Ser Phe Ala Asp Lys Val Gly Asn 
                245                 250                 255     


Cys Cys Phe Ile Ala Gly Glu Lys Arg Ala Pro Lys Asp Ser Pro Ser 
            260                 265                 270         


Ala Ile Glu Phe Ile Ala Leu Ser Arg Thr Ile Asn Thr Leu Ile Asn 
        275                 280                 285             


Leu Ser Lys Glu Ser Gly Glu Ile Tyr Asn Arg Ala Ile Ile Leu Gln 
    290                 295                 300                 


Ile Val Glu Ser Thr Leu Lys Lys Gly Glu Ile Ser Tyr Lys Glu Leu 
305                 310                 315                 320 


Arg Glu Ile Ile Arg Leu Asp Glu Arg Leu Arg Phe Lys Asp Pro Arg 
                325                 330                 335     


Leu Asp Tyr Ser Arg Glu Ile Lys Glu Ala Glu Lys Val Lys Phe Leu 
            340                 345                 350         


Glu Phe Lys Gln Leu Lys Gly Phe Lys Lys Ala Leu Gly Glu Ser Phe 
        355                 360                 365             


Thr Thr Leu Ala Ile Ser Gln Leu Asp Glu Ile Ala Glu His Ile Ala 
    370                 375                 380                 


Leu Ile Lys Asp Arg Val Lys Leu Asn Glu Lys Leu Glu Ser Tyr Ala 
385                 390                 395                 400 


Leu Thr Lys Glu Gln Arg Glu Ala Leu Ser Asn Leu Ser Phe Ser Ala 
                405                 410                 415     


His Ile Asn Leu Ser Leu Gln Ala Leu Lys Gln Ile Leu Pro Phe Met 
            420                 425                 430         


Arg Gly Asp Asn Gly Glu Gln Cys Leu Asp Tyr Asp Glu Ser Val Glu 
        435                 440                 445             


Lys Ala Gly Leu Lys Ala Leu Ser Lys Asp Thr Leu Lys Gly Gln Met 
    450                 455                 460                 


Leu Pro Pro Leu Asn Glu Phe Glu Pro Tyr Leu Ser Asn Pro Val Val 
465                 470                 475                 480 


Ala Arg Ala Leu Ala Glu Tyr Arg Lys Val Leu Asn Val Leu Leu Lys 
                485                 490                 495     


Gln Tyr Gly Ser Pro His Lys Ile His Ile Glu Tyr Ala Arg Glu Ala 
            500                 505                 510         


Lys Leu Ser Ser Thr Glu Arg Gln Lys Tyr Glu Lys Glu Gln Lys Asp 
        515                 520                 525             


Asn Tyr Ala Ala Asn Gln Ala Ala His Lys Lys Cys Gln Glu Leu Gly 
    530                 535                 540                 


Leu Glu Pro Ser Ser Thr Asn Leu Leu Lys Leu Lys Leu Trp Gln Glu 
545                 550                 555                 560 


Gln Gly Gly Leu Cys Leu Tyr Ser Gly Ala Lys Ile Thr Ile Ser Tyr 
                565                 570                 575     


Leu Gln Asp Pro Thr Ala Leu Gln Val Asp His Ile Tyr Pro Tyr Ser 
            580                 585                 590         


Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Cys Leu Val Leu Thr Lys 
        595                 600                 605             


Ala Asn Gln Glu Lys Gly Asn Arg Thr Pro Phe Glu Ala Phe Gly Thr 
    610                 615                 620                 


Asp Ser Ala Lys Trp Gly Val Ile Thr Thr Leu Ala Gln Lys Leu Pro 
625                 630                 635                 640 


His Lys Lys Arg Arg Arg Ile Leu Asn Thr Ala Phe Asn Asp Lys Glu 
                645                 650                 655     


Ala Gly Phe Lys Leu Arg Asn Leu Asn Asp Thr Ser Tyr Ile Ala Arg 
            660                 665                 670         


Leu Val Ala Asp Tyr Thr Glu Thr Tyr Leu Glu Phe Leu Pro Leu Val 
        675                 680                 685             


Glu Ser Glu Asn Thr Thr Leu Ser Lys Gly Gln Lys Gly Ser Lys Lys 
    690                 695                 700                 


His Ile Ala Ile Val Asn Gly Val Leu Thr Ser Thr Met Arg Tyr Tyr 
705                 710                 715                 720 


Leu Gly Phe Ala Ser Lys Asp Arg Asp Asn His Leu His His Ala Leu 
                725                 730                 735     


Asp Ala Val Ile Ile Gly Phe Met Asn Asp Ser Val Ile Lys Ala Phe 
            740                 745                 750         


Ser Asp Phe Lys Lys Thr Gln Glu Thr Ser Lys Ala Ala Tyr Tyr Ala 
        755                 760                 765             


His Thr Leu Ser Lys Gln Glu Tyr Lys Lys Gln Arg Ala Phe Ile Gln 
    770                 775                 780                 


Leu Pro Ser Gly Glu Asn Phe Arg Val Ser Val Leu Glu Lys Val Glu 
785                 790                 795                 800 


Ser Val Phe Val Ser Lys Pro Pro Arg Lys Arg Val Arg Gly Ala Leu 
                805                 810                 815     


His Glu Ala Thr Phe Tyr Ser Pro Asn Asp Pro Lys Leu Leu Lys Asn 
            820                 825                 830         


Tyr Gly Gly Thr Lys Gly Val Glu Arg Ala Leu Ala Leu Gly Lys Met 
        835                 840                 845             


Arg Lys Val Gly Ala Lys Ile Val Ser Asn Gly Ala Met Val Arg Val 
    850                 855                 860                 


Asp Ile Phe Arg His Lys Ser Ser Gly Lys Phe Tyr Gly Val Pro Val 
865                 870                 875                 880 


Tyr Thr Met Asp Phe Ala Leu Gly Ile Leu Pro Asn Lys Ala Val Val 
                885                 890                 895     


Val Gly Lys Asp Gln Asn Gly Val Ile Lys Asp Trp Leu Glu Met Asp 
            900                 905                 910         


Ser Ser Tyr Glu Phe Ile Phe Ser Leu Tyr Lys Asp Asp Val Ile Leu 
        915                 920                 925             


Val Gln Lys Lys Glu Met Gln Arg Pro Glu Leu Cys Tyr Phe Val Ser 
    930                 935                 940                 


Phe Asp Thr Ser Gly Ala Ser Ile Lys Val Ala Lys His Asp Asn Asn 
945                 950                 955                 960 


Phe Ser Thr Leu Thr Glu Asn Gln Lys Leu Leu Phe Ser Asn Ala Thr 
                965                 970                 975     


Lys Glu Glu Val Val Gly Lys Ser Ile Gly Ile Gln Asn Leu Lys Val 
            980                 985                 990         


Phe Glu Lys Trp Gln Val Ser Val  Leu Gly Glu Val Lys  Arg Thr Gln 
        995                 1000                 1005             


Ser Tyr  Pro Arg Glu Asn Ile  Ser Leu Ala Ser Lys  Ala Lys Lys 
    1010                 1015                 1020             


<210> 256
<211> 1023
<212> PRT
<213> Helicobacter cinaedi

<400> 256
Met Lys Ile Tyr Ser Phe Asp Ile Gly Val Ala Ser Ile Gly Trp Ala 
1               5                   10                  15      


Phe Ile Glu Asn Glu Val Leu Gln Asp Cys Gly Ile Arg Ile Phe Thr 
            20                  25                  30          


Lys Ala Glu Asn Pro Lys Asn Gly Ala Ser Leu Ala Leu Pro Arg Arg 
        35                  40                  45              


Glu Ala Arg Gly Val Arg Lys Arg Leu Ala Arg Arg Arg Gly Arg Leu 
    50                  55                  60                  


Asn Thr Ile Lys Gln Leu Leu Cys Lys Glu Phe Gly Leu Gln Leu Glu 
65                  70                  75                  80  


Asp Tyr Leu Ser Asn Asp Gly Glu Leu Pro Lys Ala Tyr Thr Ala Ser 
                85                  90                  95      


Lys Ala Asn Pro Leu Lys Ser Pro Tyr Glu Leu Arg Thr Leu Ala Leu 
            100                 105                 110         


Ser Gln Lys Leu Asp Ser Lys Asp Leu Val Arg Val Ile Leu His Ile 
        115                 120                 125             


Ala Lys His Arg Gly Tyr Gly Asn Lys His Ala Lys Asp Ser Lys Asp 
    130                 135                 140                 


Thr Glu Ser Gly Lys Val Lys Lys Ala Ile Glu Phe Asn Arg Lys Thr 
145                 150                 155                 160 


Leu Ala Glu Lys Gly Tyr Arg Ser Val Gly Glu Tyr Leu Tyr Arg Glu 
                165                 170                 175     


Phe Phe Gln Gln Ser Arg Ile Ser Gln Asn Asn Gly Ala Thr Glu Phe 
            180                 185                 190         


Ile Asn Val Arg Asn Lys Ala Gly Asn Tyr Glu His Cys Val Ala Gln 
        195                 200                 205             


Asp Met Leu Lys Glu Glu Leu Glu Ser Ile Leu Asn Ala Gln Arg Gln 
    210                 215                 220                 


Phe Gly Phe Ser Leu Lys Gln Asp Phe Glu Asn Lys Leu Leu Thr Lys 
225                 230                 235                 240 


Ile Phe Glu Gln Arg Pro Leu Lys Ser Phe Ala Asp Lys Val Gly Asn 
                245                 250                 255     


Cys Cys Phe Ile Ala Gly Glu Lys Arg Thr Pro Lys Asp Ser Leu Ser 
            260                 265                 270         


Ala Ile Glu Phe Ile Ala Leu Ser Arg Thr Ile Asn Thr Leu Ile Asn 
        275                 280                 285             


Leu Ser Lys Glu Ser Gly Glu Ile Tyr Asn Arg Ala Ile Ile Leu Gln 
    290                 295                 300                 


Ile Val Glu Ser Thr Leu Lys Lys Gly Glu Ile Ser Tyr Lys Glu Leu 
305                 310                 315                 320 


Arg Glu Ile Ile Arg Leu Asp Glu Arg Leu Arg Phe Lys Asp Pro Arg 
                325                 330                 335     


Leu Asp Tyr Ser Arg Glu Ile Lys Glu Ala Glu Lys Val Lys Phe Leu 
            340                 345                 350         


Glu Phe Lys Gln Leu Lys Gly Phe Lys Lys Ala Leu Gly Glu Ser Phe 
        355                 360                 365             


Thr Thr Leu Ala Arg Ser Gln Leu Asp Glu Ile Ala Glu His Ile Ala 
    370                 375                 380                 


Leu Ile Lys Asp Arg Val Lys Leu Asn Glu Lys Leu Glu Ser Tyr Ala 
385                 390                 395                 400 


Leu Thr Lys Glu Gln Arg Glu Ala Leu Ser Asn Leu Ser Phe Ser Ala 
                405                 410                 415     


His Ile Asn Leu Ser Leu Gln Ala Leu Lys Gln Ile Leu Pro Phe Met 
            420                 425                 430         


Arg Gly Asp Asn Gly Glu Gln Cys Leu Asp Tyr Asp Glu Ser Val Glu 
        435                 440                 445             


Lys Ala Gly Leu Lys Ala Leu Ser Lys Asp Thr Leu Lys Gly Gln Met 
    450                 455                 460                 


Leu Pro Pro Leu Asn Glu Phe Glu Pro Tyr Leu Ser Asn Pro Val Val 
465                 470                 475                 480 


Ala Arg Ala Leu Ala Glu Tyr Arg Lys Val Leu Asn Ala Leu Leu Lys 
                485                 490                 495     


Gln Tyr Gly Ser Pro His Lys Ile His Ile Glu Tyr Ala Arg Glu Ala 
            500                 505                 510         


Lys Leu Ser Ser Thr Glu Arg Gln Lys Tyr Glu Lys Glu Gln Lys Asp 
        515                 520                 525             


Asn Tyr Ala Ala Asn Gln Ala Ala His Lys Lys Cys Gln Glu Leu Gly 
    530                 535                 540                 


Leu Glu Pro Ser Ser Thr Asn Leu Leu Lys Leu Lys Leu Trp Gln Glu 
545                 550                 555                 560 


Gln Gly Gly Leu Cys Leu Tyr Ser Gly Ala Lys Ile Thr Ile Ser Tyr 
                565                 570                 575     


Leu Gln Asp Pro Thr Ala Leu Gln Val Asp His Ile Tyr Pro Tyr Ser 
            580                 585                 590         


Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Cys Leu Val Leu Thr Lys 
        595                 600                 605             


Ala Asn Gln Glu Lys Gly Asn Arg Thr Pro Phe Glu Ala Phe Gly Thr 
    610                 615                 620                 


Asp Ser Ala Lys Trp Gly Val Ile Thr Thr Leu Ala Gln Lys Leu Pro 
625                 630                 635                 640 


His Lys Lys Arg Arg Arg Ile Leu Asn Thr Ala Phe Asn Asp Lys Glu 
                645                 650                 655     


Ala Gly Phe Lys Leu Arg Asn Leu Asn Asp Thr Ser Tyr Ile Ala Arg 
            660                 665                 670         


Leu Val Ala Asp Tyr Thr Glu Thr Tyr Leu Glu Phe Leu Pro Leu Val 
        675                 680                 685             


Glu Ser Glu Asn Thr Thr Leu Gly Lys Gly Gln Lys Gly Ser Lys Lys 
    690                 695                 700                 


His Ile Ala Ile Val Asn Gly Ala Leu Thr Ser Thr Met Arg Tyr Tyr 
705                 710                 715                 720 


Leu Gly Phe Ala Ser Lys Asp Arg Asp Asn His Leu His His Ala Leu 
                725                 730                 735     


Asp Ala Val Ile Ile Gly Phe Met Asn Asp Ser Val Ile Lys Ala Phe 
            740                 745                 750         


Ser Asp Phe Lys Lys Thr Gln Glu Thr Ser Lys Ala Ala Tyr Tyr Ala 
        755                 760                 765             


His Thr Leu Ser Lys Gln Glu Tyr Lys Lys Gln Arg Ala Phe Ile Gln 
    770                 775                 780                 


Leu Pro Ser Gly Glu Asn Phe Arg Ala Ser Val Leu Glu Lys Val Glu 
785                 790                 795                 800 


Ser Val Phe Val Ser Lys Pro Pro Arg Lys Arg Val Arg Gly Ala Leu 
                805                 810                 815     


His Glu Ala Thr Phe Tyr Ser Pro Asn Asp Pro Lys Leu Leu Lys Asn 
            820                 825                 830         


Tyr Gly Gly Thr Lys Gly Val Glu Arg Ala Leu Ala Leu Gly Lys Met 
        835                 840                 845             


Arg Lys Val Gly Ala Lys Ile Val Ser Asn Gly Ala Met Val Arg Val 
    850                 855                 860                 


Asp Ile Phe Arg His Lys Ser Ser Gly Lys Phe Tyr Gly Val Pro Val 
865                 870                 875                 880 


Tyr Thr Met Asp Phe Ala Leu Gly Ile Leu Pro Asn Lys Ala Val Val 
                885                 890                 895     


Val Gly Lys Asp Lys Asn Gly Val Ile Lys Asp Trp Leu Glu Met Asp 
            900                 905                 910         


Ser Ser Tyr Glu Phe Ile Phe Ser Leu Tyr Lys Asp Asp Leu Leu Leu 
        915                 920                 925             


Val Gln Lys Lys Glu Met Ala Glu Pro Glu Leu Cys Tyr Phe Met Ser 
    930                 935                 940                 


Phe Asn Ser Ser Ile Ala Gln Ile Ser Val Ala Lys His Asp Asn Asn 
945                 950                 955                 960 


Phe Ser Thr Leu Thr Lys Asn Gln Lys Leu Leu Phe Ser Asn Ala Thr 
                965                 970                 975     


Gln Glu Asp Val Ser Gly Lys Ser Ile Gly Ile Gln Asn Leu Gln Val 
            980                 985                 990         


Phe Glu Lys Trp Gln Val Ser Val  Leu Gly Glu Val Lys  Arg Thr Gln 
        995                 1000                 1005             


Ser Tyr  Pro Arg Glu Asn Ile  Ser Leu Ala Ser Lys  Ala Lys Lys 
    1010                 1015                 1020             


<210> 257
<211> 1024
<212> PRT
<213> Helicobacter mustelae

<400> 257
Met Ile Arg Thr Leu Gly Ile Asp Ile Gly Ile Ala Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Ile Glu Gly Glu Tyr Thr Asp Lys Gly Leu Glu Asn Lys Glu 
            20                  25                  30          


Ile Val Ala Ser Gly Val Arg Val Phe Thr Lys Ala Glu Asn Pro Lys 
        35                  40                  45              


Asn Lys Glu Ser Leu Ala Leu Pro Arg Thr Leu Ala Arg Ser Ala Arg 
    50                  55                  60                  


Arg Arg Asn Ala Arg Lys Lys Gly Arg Ile Gln Gln Val Lys His Tyr 
65                  70                  75                  80  


Leu Ser Lys Ala Leu Gly Leu Asp Leu Glu Cys Phe Val Gln Gly Glu 
                85                  90                  95      


Lys Leu Ala Thr Leu Phe Gln Thr Ser Lys Asp Phe Leu Ser Pro Trp 
            100                 105                 110         


Glu Leu Arg Glu Arg Ala Leu Tyr Arg Val Leu Asp Lys Glu Glu Leu 
        115                 120                 125             


Ala Arg Val Ile Leu His Ile Ala Lys Arg Arg Gly Tyr Asp Asp Ile 
    130                 135                 140                 


Thr Tyr Gly Val Glu Asp Asn Asp Ser Gly Lys Ile Lys Lys Ala Ile 
145                 150                 155                 160 


Ala Glu Asn Ser Lys Arg Ile Lys Glu Glu Gln Cys Lys Thr Ile Gly 
                165                 170                 175     


Glu Met Met Tyr Lys Leu Tyr Phe Gln Lys Ser Leu Asn Val Arg Asn 
            180                 185                 190         


Lys Lys Glu Ser Tyr Asn Arg Cys Val Gly Arg Ser Glu Leu Arg Glu 
        195                 200                 205             


Glu Leu Lys Thr Ile Phe Gln Ile Gln Gln Glu Leu Lys Ser Pro Trp 
    210                 215                 220                 


Val Asn Glu Glu Leu Ile Tyr Lys Leu Leu Gly Asn Pro Asp Ala Gln 
225                 230                 235                 240 


Ser Lys Gln Glu Arg Glu Gly Leu Ile Phe Tyr Gln Arg Pro Leu Lys 
                245                 250                 255     


Gly Phe Gly Asp Lys Ile Gly Lys Cys Ser His Ile Lys Lys Gly Glu 
            260                 265                 270         


Asn Ser Pro Tyr Arg Ala Cys Lys His Ala Pro Ser Ala Glu Glu Phe 
        275                 280                 285             


Val Ala Leu Thr Lys Ser Ile Asn Phe Leu Lys Asn Leu Thr Asn Arg 
    290                 295                 300                 


His Gly Leu Cys Phe Ser Gln Glu Asp Met Cys Val Tyr Leu Gly Lys 
305                 310                 315                 320 


Ile Leu Gln Glu Ala Gln Lys Asn Glu Lys Gly Leu Thr Tyr Ser Lys 
                325                 330                 335     


Leu Lys Leu Leu Leu Asp Leu Pro Ser Asp Phe Glu Phe Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ser Gly Lys Asn Pro Glu Lys Ala Val Phe Leu Ser Leu Pro 
        355                 360                 365             


Ser Thr Phe Lys Leu Asn Lys Ile Thr Gln Asp Arg Lys Thr Gln Asp 
    370                 375                 380                 


Lys Ile Ala Asn Ile Leu Gly Ala Asn Lys Asp Trp Glu Ala Ile Leu 
385                 390                 395                 400 


Lys Glu Leu Glu Ser Leu Gln Leu Ser Lys Glu Gln Ile Gln Thr Ile 
                405                 410                 415     


Lys Asp Ala Lys Leu Asn Phe Ser Lys His Ile Asn Leu Ser Leu Glu 
            420                 425                 430         


Ala Leu Tyr His Leu Leu Pro Leu Met Arg Glu Gly Lys Arg Tyr Asp 
        435                 440                 445             


Glu Gly Val Glu Ile Leu Gln Glu Arg Gly Ile Phe Ser Lys Pro Gln 
    450                 455                 460                 


Pro Lys Asn Arg Gln Leu Leu Pro Pro Leu Ser Glu Leu Ala Lys Glu 
465                 470                 475                 480 


Glu Ser Tyr Phe Asp Ile Pro Asn Pro Val Leu Arg Arg Ala Leu Ser 
                485                 490                 495     


Glu Phe Arg Lys Val Val Asn Ala Leu Leu Glu Lys Tyr Gly Gly Phe 
            500                 505                 510         


His Tyr Phe His Ile Glu Leu Thr Arg Asp Val Cys Lys Ala Lys Ser 
        515                 520                 525             


Ala Arg Met Gln Leu Glu Lys Ile Asn Lys Lys Asn Lys Ser Glu Asn 
    530                 535                 540                 


Asp Ala Ala Ser Gln Leu Leu Glu Val Leu Gly Leu Pro Asn Thr Tyr 
545                 550                 555                 560 


Asn Asn Arg Leu Lys Cys Lys Leu Trp Lys Gln Gln Glu Glu Tyr Cys 
                565                 570                 575     


Leu Tyr Ser Gly Glu Lys Ile Thr Ile Asp His Leu Lys Asp Gln Arg 
            580                 585                 590         


Ala Leu Gln Ile Asp His Ala Phe Pro Leu Ser Arg Ser Leu Asp Asp 
        595                 600                 605             


Ser Gln Ser Asn Lys Val Leu Cys Leu Thr Ser Ser Asn Gln Glu Lys 
    610                 615                 620                 


Ser Asn Lys Thr Pro Tyr Glu Trp Leu Gly Ser Asp Glu Lys Lys Trp 
625                 630                 635                 640 


Asp Met Tyr Val Gly Arg Val Tyr Ser Ser Asn Phe Ser Pro Ser Lys 
                645                 650                 655     


Lys Arg Lys Leu Thr Gln Lys Asn Phe Lys Glu Arg Asn Glu Glu Asp 
            660                 665                 670         


Phe Leu Ala Arg Asn Leu Val Asp Thr Gly Tyr Ile Gly Arg Val Thr 
        675                 680                 685             


Lys Glu Tyr Ile Lys His Ser Leu Ser Phe Leu Pro Leu Pro Asp Gly 
    690                 695                 700                 


Lys Lys Glu His Ile Arg Ile Ile Ser Gly Ser Met Thr Ser Thr Met 
705                 710                 715                 720 


Arg Ser Phe Trp Gly Val Gln Glu Lys Asn Arg Asp His His Leu His 
                725                 730                 735     


His Ala Gln Asp Ala Ile Ile Ile Ala Cys Ile Glu Pro Ser Met Ile 
            740                 745                 750         


Gln Lys Tyr Thr Thr Tyr Leu Lys Asp Lys Glu Thr His Arg Leu Lys 
        755                 760                 765             


Ser His Gln Lys Ala Gln Ile Leu Arg Glu Gly Asp His Lys Leu Ser 
    770                 775                 780                 


Leu Arg Trp Pro Met Ser Asn Phe Lys Asp Lys Ile Gln Glu Ser Ile 
785                 790                 795                 800 


Gln Asn Ile Ile Pro Ser His His Val Ser His Lys Val Thr Gly Glu 
                805                 810                 815     


Leu His Gln Glu Thr Val Arg Thr Lys Glu Phe Tyr Tyr Gln Ala Phe 
            820                 825                 830         


Gly Gly Glu Glu Gly Val Lys Lys Ala Leu Lys Phe Gly Lys Ile Arg 
        835                 840                 845             


Glu Ile Asn Gln Gly Ile Val Asp Asn Gly Ala Met Val Arg Val Asp 
    850                 855                 860                 


Ile Phe Lys Ser Lys Asp Lys Gly Lys Phe Tyr Ala Val Pro Ile Tyr 
865                 870                 875                 880 


Thr Tyr Asp Phe Ala Ile Gly Lys Leu Pro Asn Lys Ala Ile Val Gln 
                885                 890                 895     


Gly Lys Lys Asn Gly Ile Ile Lys Asp Trp Leu Glu Met Asp Glu Asn 
            900                 905                 910         


Tyr Glu Phe Cys Phe Ser Leu Phe Lys Asn Asp Cys Ile Lys Ile Gln 
        915                 920                 925             


Thr Lys Glu Met Gln Glu Ala Val Leu Ala Ile Tyr Lys Ser Thr Asn 
    930                 935                 940                 


Ser Ala Lys Ala Thr Ile Glu Leu Glu His Leu Ser Lys Tyr Ala Leu 
945                 950                 955                 960 


Lys Asn Glu Asp Glu Glu Lys Met Phe Thr Asp Thr Asp Lys Glu Lys 
                965                 970                 975     


Asn Lys Thr Met Thr Arg Glu Ser Cys Gly Ile Gln Gly Leu Lys Val 
            980                 985                 990         


Phe Gln Lys Val Lys Leu Ser Val  Leu Gly Glu Val Leu  Glu His Lys 
        995                 1000                 1005             


Pro Arg  Asn Arg Gln Asn Ile  Ala Leu Lys Thr Thr  Pro Lys His 
    1010                 1015                 1020             


Val 
    


<210> 258
<211> 1688
<212> PRT
<213> Ignavibacterium album

<400> 258
Met Glu Phe Lys Lys Val Leu Gly Leu Asp Ile Gly Thr Asn Ser Ile 
1               5                   10                  15      


Gly Cys Ala Leu Leu Ser Leu Pro Lys Ser Ile Gln Asp Tyr Gly Lys 
            20                  25                  30          


Gly Gly Arg Leu Glu Trp Leu Thr Ser Arg Val Ile Pro Leu Asp Ala 
        35                  40                  45              


Asp Tyr Met Lys Ala Phe Ile Asp Gly Lys Asn Gly Leu Pro Gln Val 
    50                  55                  60                  


Ile Thr Pro Ala Gly Lys Arg Arg Gln Lys Arg Gly Ser Arg Arg Leu 
65                  70                  75                  80  


Lys His Arg Tyr Lys Leu Arg Arg Ser Arg Leu Ile Arg Val Phe Lys 
                85                  90                  95      


Thr Leu Asn Trp Leu Pro Glu Asp Phe Pro Leu Asp Asn Pro Lys Arg 
            100                 105                 110         


Ile Lys Glu Thr Ile Ser Thr Glu Gly Lys Phe Ser Phe Arg Ile Ser 
        115                 120                 125             


Asp Tyr Val Pro Ile Ser Asp Glu Ser Tyr Arg Glu Phe Tyr Arg Glu 
    130                 135                 140                 


Phe Gly Tyr Pro Glu Asn Glu Ile Glu Gln Val Ile Glu Glu Ile Asn 
145                 150                 155                 160 


Phe Arg Arg Lys Thr Lys Gly Lys Asn Lys Asn Pro Met Ile Lys Leu 
                165                 170                 175     


Leu Pro Glu Asp Trp Val Val Tyr Tyr Leu Arg Lys Lys Ala Leu Ile 
            180                 185                 190         


Lys Pro Thr Thr Lys Glu Glu Leu Ile Arg Ile Ile Tyr Leu Phe Asn 
        195                 200                 205             


Gln Arg Arg Gly Phe Lys Ser Ser Arg Lys Asp Leu Thr Glu Thr Ala 
    210                 215                 220                 


Ile Leu Asp Tyr Asp Glu Phe Ala Lys Arg Leu Ala Glu Lys Glu Lys 
225                 230                 235                 240 


Tyr Ser Ala Glu Asn Tyr Glu Thr Lys Phe Val Ser Ile Thr Lys Val 
                245                 250                 255     


Lys Glu Val Val Glu Leu Lys Thr Asp Gly Arg Lys Gly Lys Lys Arg 
            260                 265                 270         


Phe Lys Val Ile Leu Glu Asp Ser Arg Ile Glu Pro Tyr Glu Ile Glu 
        275                 280                 285             


Arg Lys Glu Lys Pro Asp Trp Glu Gly Lys Glu Tyr Thr Phe Leu Val 
    290                 295                 300                 


Thr Gln Lys Leu Glu Lys Gly Lys Phe Lys Gln Asn Lys Pro Asp Leu 
305                 310                 315                 320 


Pro Lys Glu Glu Asp Trp Ala Leu Cys Thr Thr Ala Leu Asp Asn Arg 
                325                 330                 335     


Met Gly Ser Lys His Pro Gly Glu Phe Phe Phe Asp Glu Leu Leu Lys 
            340                 345                 350         


Ala Phe Lys Glu Lys Arg Gly Tyr Lys Ile Arg Gln Tyr Pro Val Asn 
        355                 360                 365             


Arg Trp Arg Tyr Lys Lys Glu Leu Glu Phe Ile Trp Thr Lys Gln Cys 
    370                 375                 380                 


Gln Leu Asn Pro Glu Leu Asn Asn Leu Asn Ile Asn Lys Glu Ile Leu 
385                 390                 395                 400 


Arg Lys Leu Ala Thr Val Leu Tyr Pro Ser Gln Ser Lys Phe Phe Gly 
                405                 410                 415     


Pro Lys Ile Lys Glu Phe Glu Asn Ser Asp Val Leu His Ile Ile Ser 
            420                 425                 430         


Glu Asp Ile Ile Tyr Tyr Gln Arg Asp Leu Lys Ser Gln Lys Ser Leu 
        435                 440                 445             


Ile Ser Glu Cys Arg Tyr Glu Lys Arg Lys Gly Ile Asp Gly Glu Ile 
    450                 455                 460                 


Tyr Gly Leu Lys Cys Ile Pro Lys Ser Ser Pro Leu Tyr Gln Glu Phe 
465                 470                 475                 480 


Arg Ile Trp Gln Asp Ile His Asn Ile Lys Val Ile Arg Lys Glu Ser 
                485                 490                 495     


Glu Val Asn Gly Lys Lys Lys Ile Asn Ile Asp Glu Thr Gln Leu Tyr 
            500                 505                 510         


Ile Asn Glu Asn Ile Lys Glu Lys Leu Phe Glu Leu Phe Asn Ser Lys 
        515                 520                 525             


Asp Ser Leu Ser Glu Lys Asp Ile Leu Glu Leu Ile Ser Leu Asn Ile 
    530                 535                 540                 


Ile Asn Ser Gly Ile Lys Ile Ser Lys Lys Glu Glu Glu Thr Thr His 
545                 550                 555                 560 


Arg Ile Asn Leu Phe Ala Asn Arg Lys Glu Leu Lys Gly Asn Glu Thr 
                565                 570                 575     


Lys Ser Arg Tyr Arg Lys Val Phe Lys Lys Leu Gly Phe Asp Gly Glu 
            580                 585                 590         


Tyr Ile Leu Asn His Pro Ser Lys Leu Asn Arg Leu Trp His Ser Asp 
        595                 600                 605             


Tyr Ser Asn Asp Tyr Ala Asp Lys Glu Lys Thr Glu Lys Ser Ile Leu 
    610                 615                 620                 


Ser Ser Leu Gly Trp Lys Asn Arg Asn Gly Lys Trp Glu Lys Ser Lys 
625                 630                 635                 640 


Asn Tyr Asp Val Phe Asn Leu Pro Leu Glu Val Ala Lys Ala Ile Ala 
                645                 650                 655     


Asn Leu Pro Pro Leu Lys Lys Glu Tyr Gly Ser Tyr Ser Ala Leu Ala 
            660                 665                 670         


Ile Arg Lys Met Leu Val Val Met Arg Asp Gly Lys Tyr Trp Gln His 
        675                 680                 685             


Pro Asp Gln Ile Ala Lys Asp Gln Glu Asn Thr Ser Leu Met Leu Phe 
    690                 695                 700                 


Asp Lys Asn Leu Ile Gln Leu Thr Asn Asn Gln Arg Lys Val Leu Asn 
705                 710                 715                 720 


Lys Tyr Leu Leu Thr Leu Ala Glu Val Gln Lys Arg Ser Thr Leu Ile 
                725                 730                 735     


Lys Gln Lys Leu Asn Glu Ile Glu His Asn Pro Tyr Lys Leu Glu Leu 
            740                 745                 750         


Val Ser Asp Gln Asp Leu Glu Lys Gln Val Leu Lys Ser Phe Leu Glu 
        755                 760                 765             


Lys Lys Asn Glu Ser Asp Tyr Leu Lys Gly Leu Lys Thr Tyr Gln Ala 
    770                 775                 780                 


Gly Tyr Leu Ile Tyr Gly Lys His Ser Glu Lys Asp Val Pro Ile Val 
785                 790                 795                 800 


Asn Ser Pro Asp Glu Leu Gly Glu Tyr Ile Arg Lys Lys Leu Pro Asn 
                805                 810                 815     


Asn Ser Leu Arg Asn Pro Ile Val Glu Gln Val Ile Arg Glu Thr Ile 
            820                 825                 830         


Phe Ile Val Arg Asp Val Trp Lys Ser Phe Gly Ile Ile Asp Glu Ile 
        835                 840                 845             


His Ile Glu Leu Gly Arg Glu Leu Lys Asn Asn Ser Glu Glu Arg Lys 
    850                 855                 860                 


Lys Thr Ser Glu Ser Gln Glu Lys Asn Phe Gln Glu Lys Glu Arg Ala 
865                 870                 875                 880 


Arg Lys Leu Leu Lys Glu Leu Leu Asn Ser Ser Asn Phe Glu His Tyr 
                885                 890                 895     


Asp Glu Asn Gly Asn Lys Ile Phe Ser Ser Phe Thr Val Asn Pro Asn 
            900                 905                 910         


Pro Asp Ser Pro Leu Asp Ile Glu Lys Phe Arg Ile Trp Lys Asn Gln 
        915                 920                 925             


Ser Gly Leu Thr Asp Glu Glu Leu Asn Lys Lys Leu Lys Asp Glu Lys 
    930                 935                 940                 


Ile Pro Thr Glu Ile Glu Val Lys Lys Tyr Ile Leu Trp Leu Thr Gln 
945                 950                 955                 960 


Lys Cys Arg Ser Pro Tyr Thr Gly Lys Ile Ile Pro Leu Ser Lys Leu 
                965                 970                 975     


Phe Asp Ser Asn Val Tyr Glu Ile Glu His Ile Ile Pro Arg Ser Lys 
            980                 985                 990         


Met Lys Asn Asp Ser Thr Asn Asn  Leu Val Ile Cys Glu  Leu Gly Val 
        995                 1000                 1005             


Asn Lys  Ala Lys Gly Asp Arg  Leu Ala Ala Asn Phe  Ile Ser Glu 
    1010                 1015                 1020             


Ser Asn  Gly Lys Cys Lys Phe  Gly Glu Val Glu Tyr  Thr Leu Leu 
    1025                 1030                 1035             


Lys Tyr  Gly Asp Tyr Leu Gln  Tyr Cys Lys Asp Thr  Phe Lys Tyr 
    1040                 1045                 1050             


Gln Lys  Ala Lys Tyr Lys Asn  Leu Leu Ala Thr Glu  Pro Pro Glu 
    1055                 1060                 1065             


Asp Phe  Ile Glu Arg Gln Ile  Asn Asp Thr Arg Tyr  Ile Gly Arg 
    1070                 1075                 1080             


Lys Leu  Ala Glu Leu Leu Thr  Pro Val Val Lys Asp  Ser Lys Asn 
    1085                 1090                 1095             


Ile Ile  Phe Thr Ile Gly Ser  Ile Thr Ser Glu Leu  Lys Ile Thr 
    1100                 1105                 1110             


Trp Gly  Leu Asn Gly Val Trp  Lys Asp Ile Leu Arg  Pro Arg Phe 
    1115                 1120                 1125             


Lys Arg  Leu Glu Ser Ile Ile  Asn Lys Lys Leu Ile  Phe Gln Asp 
    1130                 1135                 1140             


Glu Asp  Asp Pro Asn Lys Tyr  His Phe Asp Leu Ser  Ile Asn Pro 
    1145                 1150                 1155             


Gln Leu  Asp Lys Glu Gly Leu  Lys Arg Leu Asp His  Arg His His 
    1160                 1165                 1170             


Ala Leu  Asp Ala Thr Ile Ile  Ala Ala Thr Thr Arg  Glu His Val 
    1175                 1180                 1185             


Arg Tyr  Leu Asn Ser Leu Asn  Ala Ala Asp Asn Asp  Glu Glu Lys 
    1190                 1195                 1200             


Arg Glu  Tyr Phe Leu Ser Leu  Cys Asn His Lys Ile  Arg Asp Phe 
    1205                 1210                 1215             


Lys Leu  Pro Trp Glu Asn Phe  Thr Ser Glu Val Lys  Ser Lys Leu 
    1220                 1225                 1230             


Leu Ser  Cys Val Val Ser Tyr  Lys Glu Ser Lys Pro  Ile Leu Ser 
    1235                 1240                 1245             


Asp Pro  Phe Asn Lys Tyr Leu  Lys Trp Glu Tyr Lys  Asn Gly Lys 
    1250                 1255                 1260             


Trp Gln  Lys Val Phe Ala Ile  Gln Ile Lys Asn Asp  Arg Trp Lys 
    1265                 1270                 1275             


Ala Val  Arg Arg Ser Met Phe  Lys Glu Pro Ile Gly  Thr Val Trp 
    1280                 1285                 1290             


Ile Lys  Lys Ile Lys Glu Val  Ser Leu Lys Glu Ala  Ile Lys Ile 
    1295                 1300                 1305             


Gln Ala  Ile Trp Glu Glu Val  Lys Asn Asp Pro Val  Arg Lys Lys 
    1310                 1315                 1320             


Lys Glu  Lys Tyr Ile Tyr Asp  Asp Tyr Ala Gln Lys  Val Ile Ala 
    1325                 1330                 1335             


Lys Ile  Val Gln Glu Leu Gly  Leu Ser Ser Ser Met  Arg Lys Gln 
    1340                 1345                 1350             


Asp Asp  Glu Lys Leu Asn Lys  Phe Ile Asn Glu Ala  Lys Val Ser 
    1355                 1360                 1365             


Ala Gly  Val Asn Lys Asn Leu  Asn Thr Thr Asn Lys  Thr Ile Tyr 
    1370                 1375                 1380             


Asn Leu  Glu Gly Arg Phe Tyr  Glu Lys Ile Lys Val  Ala Glu Tyr 
    1385                 1390                 1395             


Val Leu  Tyr Lys Ala Lys Arg  Met Pro Leu Asn Lys  Lys Glu Tyr 
    1400                 1405                 1410             


Ile Glu  Lys Leu Ser Leu Gln  Lys Met Phe Asn Asp  Leu Pro Asn 
    1415                 1420                 1425             


Phe Ile  Leu Glu Lys Ser Ile  Leu Asp Asn Tyr Pro  Glu Ile Leu 
    1430                 1435                 1440             


Lys Glu  Leu Glu Ser Asp Asn  Lys Tyr Ile Ile Glu  Pro His Lys 
    1445                 1450                 1455             


Lys Asn  Asn Pro Val Asn Arg  Leu Leu Leu Glu His  Ile Leu Glu 
    1460                 1465                 1470             


Tyr His  Asn Asn Pro Lys Glu  Ala Phe Ser Thr Glu  Gly Leu Glu 
    1475                 1480                 1485             


Lys Leu  Asn Lys Lys Ala Ile  Asn Lys Ile Gly Lys  Pro Ile Lys 
    1490                 1495                 1500             


Tyr Ile  Thr Arg Leu Asp Gly  Asp Ile Asn Glu Glu  Glu Ile Phe 
    1505                 1510                 1515             


Arg Gly  Ala Val Phe Glu Thr  Asp Lys Gly Ser Asn  Val Tyr Phe 
    1520                 1525                 1530             


Val Met  Tyr Glu Asn Asn Gln  Thr Lys Asp Arg Glu  Phe Leu Lys 
    1535                 1540                 1545             


Pro Asn  Pro Ser Ile Ser Val  Leu Lys Ala Ile Glu  His Lys Asn 
    1550                 1555                 1560             


Lys Ile  Asp Phe Phe Ala Pro  Asn Arg Leu Gly Phe  Ser Arg Ile 
    1565                 1570                 1575             


Ile Leu  Ser Pro Gly Asp Leu  Val Tyr Val Pro Thr  Asn Asp Gln 
    1580                 1585                 1590             


Tyr Val  Leu Ile Lys Asp Asn  Ser Ser Asn Glu Thr  Ile Ile Asn 
    1595                 1600                 1605             


Trp Asp  Asp Asn Glu Phe Ile  Ser Asn Arg Ile Tyr  Gln Val Lys 
    1610                 1615                 1620             


Lys Phe  Thr Gly Asn Ser Cys  Tyr Phe Leu Lys Asn  Asp Ile Ala 
    1625                 1630                 1635             


Ser Leu  Ile Leu Ser Tyr Ser  Ala Ser Asn Gly Val  Gly Glu Phe 
    1640                 1645                 1650             


Gly Ser  Gln Asn Ile Ser Glu  Tyr Ser Val Asp Asp  Pro Pro Ile 
    1655                 1660                 1665             


Arg Ile  Lys Asp Val Cys Ile  Lys Ile Arg Val Asp  Arg Leu Gly 
    1670                 1675                 1680             


Asn Val  Arg Pro Leu 
    1685             


<210> 259
<211> 1092
<212> PRT
<213> Ilyobacter polytropus

<400> 259
Met Lys Tyr Ser Ile Gly Leu Asp Ile Gly Ile Ala Ser Val Gly Trp 
1               5                   10                  15      


Ser Val Ile Asn Lys Asp Lys Glu Arg Ile Glu Asp Met Gly Val Arg 
            20                  25                  30          


Ile Phe Gln Lys Ala Glu Asn Pro Lys Asp Gly Ser Ser Leu Ala Ser 
        35                  40                  45              


Ser Arg Arg Glu Lys Arg Gly Ser Arg Arg Arg Asn Arg Arg Lys Lys 
    50                  55                  60                  


His Arg Leu Asp Arg Ile Lys Asn Ile Leu Cys Glu Ser Gly Leu Val 
65                  70                  75                  80  


Lys Lys Asn Glu Ile Glu Lys Ile Tyr Lys Asn Ala Tyr Leu Lys Ser 
                85                  90                  95      


Pro Trp Glu Leu Arg Ala Lys Ser Leu Glu Ala Lys Ile Ser Asn Lys 
            100                 105                 110         


Glu Ile Ala Gln Ile Leu Leu His Ile Ala Lys Arg Arg Gly Phe Lys 
        115                 120                 125             


Ser Phe Arg Lys Thr Asp Arg Asn Ala Asp Asp Thr Gly Lys Leu Leu 
    130                 135                 140                 


Ser Gly Ile Gln Glu Asn Lys Lys Ile Met Glu Glu Lys Gly Tyr Leu 
145                 150                 155                 160 


Thr Ile Gly Asp Met Val Ala Lys Asp Pro Lys Phe Asn Thr His Val 
                165                 170                 175     


Arg Asn Lys Ala Gly Ser Tyr Leu Phe Ser Phe Ser Arg Lys Leu Leu 
            180                 185                 190         


Glu Asp Glu Val Arg Lys Ile Gln Ala Lys Gln Lys Glu Leu Gly Asn 
        195                 200                 205             


Thr His Phe Thr Asp Asp Val Leu Glu Lys Tyr Ile Glu Val Phe Asn 
    210                 215                 220                 


Ser Gln Arg Asn Phe Asp Glu Gly Pro Ser Lys Pro Ser Pro Tyr Tyr 
225                 230                 235                 240 


Ser Glu Ile Gly Gln Ile Ala Lys Met Ile Gly Asn Cys Thr Phe Glu 
                245                 250                 255     


Ser Ser Glu Lys Arg Thr Ala Lys Asn Thr Trp Ser Gly Glu Arg Phe 
            260                 265                 270         


Val Phe Leu Gln Lys Leu Asn Asn Phe Arg Ile Val Gly Leu Ser Gly 
        275                 280                 285             


Lys Arg Pro Leu Thr Glu Glu Glu Arg Asp Ile Val Glu Lys Glu Val 
    290                 295                 300                 


Tyr Leu Lys Lys Glu Val Arg Tyr Glu Lys Leu Arg Lys Ile Leu Tyr 
305                 310                 315                 320 


Leu Lys Glu Glu Glu Arg Phe Gly Asp Leu Asn Tyr Ser Lys Asp Glu 
                325                 330                 335     


Lys Gln Asp Lys Lys Thr Glu Lys Thr Lys Phe Ile Ser Leu Ile Gly 
            340                 345                 350         


Asn Tyr Thr Ile Lys Lys Leu Asn Leu Ser Glu Lys Leu Lys Ser Glu 
        355                 360                 365             


Ile Glu Glu Asp Lys Ser Lys Leu Asp Lys Ile Ile Glu Ile Leu Thr 
    370                 375                 380                 


Phe Asn Lys Ser Asp Lys Thr Ile Glu Ser Asn Leu Lys Lys Leu Glu 
385                 390                 395                 400 


Leu Ser Arg Glu Asp Ile Glu Ile Leu Leu Ser Glu Glu Phe Ser Gly 
                405                 410                 415     


Thr Leu Asn Leu Ser Leu Lys Ala Ile Lys Lys Ile Leu Pro Tyr Leu 
            420                 425                 430         


Glu Lys Gly Leu Ser Tyr Asn Glu Ala Cys Glu Lys Ala Asp Tyr Asp 
        435                 440                 445             


Tyr Lys Asn Asn Gly Ile Lys Phe Lys Arg Gly Glu Leu Leu Pro Val 
    450                 455                 460                 


Val Asp Lys Asp Leu Ile Ala Asn Pro Val Val Leu Arg Ala Ile Ser 
465                 470                 475                 480 


Gln Thr Arg Lys Val Val Asn Ala Ile Ile Arg Lys Tyr Gly Thr Pro 
                485                 490                 495     


His Thr Ile His Val Glu Val Ala Arg Asp Leu Ala Lys Ser Tyr Asp 
            500                 505                 510         


Asp Arg Gln Thr Ile Ile Lys Glu Asn Lys Lys Arg Glu Leu Glu Asn 
        515                 520                 525             


Glu Lys Thr Lys Lys Phe Ile Ser Glu Glu Phe Gly Ile Lys Asn Val 
    530                 535                 540                 


Lys Gly Lys Leu Leu Leu Lys Tyr Arg Leu Tyr Gln Glu Gln Glu Gly 
545                 550                 555                 560 


Arg Cys Ala Tyr Ser Arg Lys Glu Leu Ser Leu Ser Glu Val Ile Leu 
                565                 570                 575     


Asp Glu Ser Met Thr Asp Ile Asp His Ile Ile Pro Tyr Ser Arg Ser 
            580                 585                 590         


Met Asp Asp Ser Tyr Ser Asn Lys Val Leu Val Leu Ser Gly Glu Asn 
        595                 600                 605             


Arg Lys Lys Ser Asn Leu Leu Pro Lys Glu Tyr Phe Asp Arg Gln Gly 
    610                 615                 620                 


Arg Asp Trp Asp Thr Phe Val Leu Asn Val Lys Ala Met Lys Ile His 
625                 630                 635                 640 


Pro Arg Lys Lys Ser Asn Leu Leu Lys Glu Lys Phe Thr Arg Glu Asp 
                645                 650                 655     


Asn Lys Asp Trp Lys Ser Arg Ala Leu Asn Asp Thr Arg Tyr Ile Ser 
            660                 665                 670         


Arg Phe Val Ala Asn Tyr Leu Glu Asn Ala Leu Glu Tyr Arg Asp Asp 
        675                 680                 685             


Ser Pro Lys Lys Arg Val Phe Met Ile Pro Gly Gln Leu Thr Ala Gln 
    690                 695                 700                 


Leu Arg Ala Arg Trp Arg Leu Asn Lys Val Arg Glu Asn Gly Asp Leu 
705                 710                 715                 720 


His His Ala Leu Asp Ala Ala Val Val Ala Val Thr Asp Gln Lys Ala 
                725                 730                 735     


Ile Asn Asn Ile Ser Asn Ile Ser Arg Tyr Lys Glu Leu Lys Asn Cys 
            740                 745                 750         


Lys Asp Val Ile Pro Ser Ile Glu Tyr His Ala Asp Glu Glu Thr Gly 
        755                 760                 765             


Glu Val Tyr Phe Glu Glu Val Lys Asp Thr Arg Phe Pro Met Pro Trp 
    770                 775                 780                 


Ser Gly Phe Asp Leu Glu Leu Gln Lys Arg Leu Glu Ser Glu Asn Pro 
785                 790                 795                 800 


Arg Glu Glu Phe Tyr Asn Leu Leu Ser Asp Lys Arg Tyr Leu Gly Trp 
                805                 810                 815     


Phe Asn Tyr Glu Glu Gly Phe Ile Glu Lys Leu Arg Pro Val Phe Val 
            820                 825                 830         


Ser Arg Met Pro Asn Arg Gly Val Lys Gly Gln Ala His Gln Glu Thr 
        835                 840                 845             


Ile Arg Ser Ser Lys Lys Ile Ser Asn Gln Ile Ala Val Ser Lys Lys 
    850                 855                 860                 


Pro Leu Asn Ser Ile Lys Leu Lys Asp Leu Glu Lys Met Gln Gly Arg 
865                 870                 875                 880 


Asp Thr Asp Arg Lys Leu Tyr Glu Ala Leu Lys Asn Arg Leu Glu Glu 
                885                 890                 895     


Tyr Asp Asp Lys Pro Glu Lys Ala Phe Ala Glu Pro Phe Tyr Lys Pro 
            900                 905                 910         


Thr Asn Ser Gly Lys Arg Gly Pro Leu Val Arg Gly Ile Lys Val Glu 
        915                 920                 925             


Glu Lys Gln Asn Val Gly Val Tyr Val Asn Gly Gly Gln Ala Ser Asn 
    930                 935                 940                 


Gly Ser Met Val Arg Ile Asp Val Phe Arg Lys Asn Gly Lys Phe Tyr 
945                 950                 955                 960 


Thr Val Pro Ile Tyr Val His Gln Thr Leu Leu Lys Glu Leu Pro Asn 
                965                 970                 975     


Arg Ala Ile Asn Gly Lys Pro Tyr Lys Asp Trp Asp Leu Ile Asp Gly 
            980                 985                 990         


Ser Phe Glu Phe Leu Tyr Ser Phe  Tyr Pro Asn Asp Leu  Ile Glu Ile 
        995                 1000                 1005             


Glu Phe  Gly Lys Ser Lys Ser  Ile Lys Asn Asp Asn  Lys Leu Thr 
    1010                 1015                 1020             


Lys Thr  Glu Ile Pro Glu Val  Asn Leu Ser Glu Val  Leu Gly Tyr 
    1025                 1030                 1035             


Tyr Arg  Gly Met Asp Thr Ser  Thr Gly Ala Ala Thr  Ile Asp Thr 
    1040                 1045                 1050             


Gln Asp  Gly Lys Ile Gln Met  Arg Ile Gly Ile Lys  Thr Val Lys 
    1055                 1060                 1065             


Asn Ile  Lys Lys Tyr Gln Val  Asp Val Leu Gly Asn  Val Tyr Lys 
    1070                 1075                 1080             


Val Lys  Arg Glu Lys Arg Gln  Thr Phe 
    1085                 1090         


<210> 260
<211> 1354
<212> PRT
<213> Indibacter alkaliphilus


<220>
<223> Indibacter alkaliphilus LW1

<400> 260
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ile Lys Glu Pro Glu Lys Asp Val Val Gly Ser Glu Ile Val 
            20                  25                  30          


Asp Met Gly Val Arg Ile Val Pro Leu Ser Ser Asp Glu Glu Asn Asp 
        35                  40                  45              


Phe Ala Lys Gly Asn Thr Ile Ser Ile Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Ala Arg Arg Asn Leu Gln Arg Phe Lys Gln Arg Arg Asn Ala 
65                  70                  75                  80  


Leu Leu Glu Thr Phe Lys Glu Lys Asn Leu Ile Pro Ser Asn Phe Gln 
                85                  90                  95      


Tyr Ala Glu Asp Gly Pro Ser Ser Thr Phe Ser Thr Leu Lys Leu Arg 
            100                 105                 110         


Asp Lys Ala Ala Lys Glu Lys Ile Glu Leu Asp Asp Phe Val Lys Val 
        115                 120                 125             


Leu Leu Gln Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Met Ser Glu Glu Asp Glu Gly Thr Ala Ile Asp Ser Met Gly Ile Ala 
145                 150                 155                 160 


Lys Glu Leu Tyr Glu Asn Asp Leu Thr Pro Gly Gln Trp Val Tyr Glu 
                165                 170                 175     


Ala Leu Lys Asn Gly Arg Lys Asn Val Pro Asp Phe Tyr Arg Ser Asp 
            180                 185                 190         


Leu Gln Glu Glu Phe Lys Lys Ile Val Asn Tyr Gln Ser Glu Phe Tyr 
        195                 200                 205             


Pro Asp Ile Leu Asn Thr Ser Phe Val Glu Asp Trp Met Gly Lys Ala 
    210                 215                 220                 


Ser Thr Pro Thr Lys Gln Tyr Phe Asn Lys Arg Gly Val Gln Leu Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Lys Arg Glu Glu Arg Arg Leu Gln Glu Tyr Lys Trp 
                245                 250                 255     


Arg Ala Glu Ala Val Asn Phe Lys Ile Asp Leu Ser Glu Ile Ala Leu 
            260                 265                 270         


Ile Leu Ser Gln Ile Asn Ser Gln Ile Ser Asn Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Lys Asn Leu Thr 
    290                 295                 300                 


Val Gly Gln Tyr Leu Tyr Gln Gln Val Lys Lys Asn Pro His Thr Arg 
305                 310                 315                 320 


Leu Lys Gly Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Lys Ile Trp Ser Val Gln Ser Ser Phe Tyr Pro Gln Leu Asn Asp Glu 
            340                 345                 350         


Leu Lys Gln Glu Val Arg Asp Val Thr Ile Phe Phe Gln Arg Arg Leu 
        355                 360                 365             


Lys Ser Gln Lys His Leu Ile Ser Asn Cys Glu Phe Glu Glu His His 
    370                 375                 380                 


Lys Val Val Pro Lys Ser His Pro Ile Phe Gln Glu Phe Arg Ile Trp 
385                 390                 395                 400 


Gln Asn Leu Asn Asn Leu Thr Leu Ile Lys Lys Asp Asn Leu Asn Glu 
                405                 410                 415     


Lys Cys Glu Leu Ala Leu Glu Asp Lys Thr Ala Leu Ala Asn Glu Leu 
            420                 425                 430         


Ala Phe Lys Lys Glu Leu Ser Val Lys Asp Ala Leu Lys Val Leu Gly 
        435                 440                 445             


Leu Lys Pro Ser Asp Trp Glu Phe Asn Phe Thr Lys Ile Glu Gly Asn 
    450                 455                 460                 


Arg Thr Asn His Ala Phe Phe Glu Ala Phe Ala Lys Ile Ile Glu Leu 
465                 470                 475                 480 


Glu Asp Gly Glu Pro Ile Asp Leu Gly Asn Leu Lys Ala Asp Asp Ile 
                485                 490                 495     


Leu Asp Gln Phe Ser Glu Ala Phe Leu Arg Ile Gly Ile Asp Thr Glu 
            500                 505                 510         


Leu Leu Gln Val Asn Ser Asp Ile Glu Gly Ala Glu Tyr Glu Lys Gln 
        515                 520                 525             


Ser Tyr Ile Gln Phe Trp His Leu Leu Tyr Ser Ser Glu Asp Asp Gln 
    530                 535                 540                 


Lys Leu Lys Gln Asn Leu Ile Arg Lys Phe Gly Phe Lys Pro Glu His 
545                 550                 555                 560 


Ala Lys Ile Leu Ala Ser Ile Ser Leu Gln Asp Asp His Ala Ser Leu 
                565                 570                 575     


Ser Ser Arg Ala Ile Lys Lys Ile Leu Pro His Leu Gln Ser Gly Leu 
            580                 585                 590         


Ile Tyr Asp Lys Ala Cys Thr Tyr Ala Gly Tyr Asn His Ser Ser Ser 
        595                 600                 605             


Phe Thr Lys Asp Glu Asn Glu Lys Arg Glu Leu Arg Ala Glu Leu Glu 
    610                 615                 620                 


Leu Leu Lys Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Leu 
625                 630                 635                 640 


Asn Gln Met Ile Asn Val Val Asn Ala Ile Leu Lys Asp Pro Asn Leu 
                645                 650                 655     


Gly Arg Pro Asp Glu Ile Arg Val Glu Met Ala Arg Glu Leu Lys Ala 
            660                 665                 670         


Asn Ala Glu Gln Arg Lys Asn Met Thr Ser Asn Ile Ala Ser Ala Thr 
        675                 680                 685             


Arg Asp His Glu Lys Tyr Arg Glu Ile Leu Lys Lys Glu Phe Gly Leu 
    690                 695                 700                 


Lys Arg Val Thr Lys Asn Asp Leu Leu Arg Tyr Lys Leu Trp Leu Glu 
705                 710                 715                 720 


Thr Asp Gly Ile Ser Leu Tyr Thr Gly Lys Pro Ile Glu Ala Ser Lys 
                725                 730                 735     


Leu Phe Ser Lys Glu Tyr Asp Ile Glu His Ile Ile Pro Lys Ala Arg 
            740                 745                 750         


Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Ile Cys Glu Arg Gln Leu 
        755                 760                 765             


Asn Ile Asp Lys Ala Asn Val Thr Ala Phe Ser Phe Leu Gln Asn Lys 
    770                 775                 780                 


Leu Ser Ala Asp Glu Phe Glu Gln Tyr Gln Ser Arg Val Lys Ser Leu 
785                 790                 795                 800 


Tyr Gly Lys Leu Ser Lys Ala Lys Ile Gln Lys Leu Leu Met Ala Asn 
                805                 810                 815     


Asp Lys Ile Pro Glu Asp Phe Ile Ala Arg Gln Leu Gln Glu Thr Arg 
            820                 825                 830         


Tyr Ile Ser Lys Lys Ala Lys Glu Ile Leu Phe Glu Ile Thr Met Arg 
        835                 840                 845             


Val Ser Val Thr Thr Gly Thr Ile Thr Asp Lys Leu Arg Glu Asp Trp 
    850                 855                 860                 


Gly Leu Val Glu Ile Met Lys Glu Leu Asn Trp Glu Lys Tyr Asp Lys 
865                 870                 875                 880 


Leu Gly Leu Thr Tyr Thr Ile Glu Gly Lys His Gly Glu Arg Leu Asn 
                885                 890                 895     


Lys Ile Lys Asp Trp Asn Lys Arg Asn Asp His Arg His His Ala Met 
            900                 905                 910         


Asp Ala Leu Thr Val Ala Leu Thr Lys Pro Ala Tyr Ile Gln Tyr Leu 
        915                 920                 925             


Asn Asn Leu Asn Ala Lys Ala Ile Gly Asn Lys Lys Gly Thr Glu Ile 
    930                 935                 940                 


Phe Ala Ile Glu Gln Lys Tyr Leu Lys Arg Glu Asn Gly Lys Leu Cys 
945                 950                 955                 960 


Phe Ile Pro Pro Ile Glu Asn Ile Arg Ala Glu Ala Lys Lys His Leu 
                965                 970                 975     


Ser Lys Ile Leu Val Ser Tyr Lys Ala Lys Asn Lys Val Val Thr Ile 
            980                 985                 990         


Asn Lys Asn Lys Thr Lys Lys Lys  Ala Gly Phe Asn Glu  Gln Thr Ala 
        995                 1000                 1005             


Leu Thr  Pro Arg Gly Gln Leu  His Lys Glu Thr Val  Tyr Gly Lys 
    1010                 1015                 1020             


Ser Phe  His Tyr Ser Thr Lys  Phe Glu Lys Ile Gly  Ala Ser Phe 
    1025                 1030                 1035             


Asp Ala  Gln Lys Ile Asn Thr  Val Ala Lys Lys Glu  Glu Arg Glu 
    1040                 1045                 1050             


Ala Leu  Leu Lys Arg Leu Ala  Glu Asn Gly Asn Asp  Pro Lys Lys 
    1055                 1060                 1065             


Ala Phe  Thr Gly Lys Asn Ser  Leu Asn Lys Met Pro  Ile Tyr Leu 
    1070                 1075                 1080             


Asp Leu  Gly Lys Asn Ile Lys  Leu Ser Glu Lys Val  Lys Thr Val 
    1085                 1090                 1095             


Val Leu  Glu Gln Asn Tyr Thr  Ile Arg Lys Asn Ile  Asp Pro Asp 
    1100                 1105                 1110             


Leu Lys  Val Asp Lys Val Ile  Asp Val Gly Ile Lys  Arg Ile Leu 
    1115                 1120                 1125             


Glu Ser  Arg Leu Glu Glu Phe  Gly Gly Asn Ala Lys  Leu Ala Phe 
    1130                 1135                 1140             


Ser Asn  Leu Glu Glu Asn Pro  Ile Trp Leu Asn Lys  Glu Lys Gly 
    1145                 1150                 1155             


Ile Pro  Ile Lys Arg Val Lys  Ile Ser Gly Val Ser  Asn Val Glu 
    1160                 1165                 1170             


Ser Leu  His Val Lys Lys Asp  His Phe Gly Glu Lys  Ile Leu Asp 
    1175                 1180                 1185             


Glu Glu  Gly Asn Glu Ile Pro  Val Asp Phe Val Ser  Thr Gly Asn 
    1190                 1195                 1200             


Asn His  His Val Ala Ile Tyr  Glu Asp Glu Asp Gly  Asn Leu Gln 
    1205                 1210                 1215             


Asp Glu  Val Val Asn Phe Tyr  Glu Ala Val Ile Arg  Arg Asn Gln 
    1220                 1225                 1230             


Gly Glu  Ser Ile Ile Lys Tyr  Arg His Glu Glu Gly  Trp Asn Phe 
    1235                 1240                 1245             


Leu Tyr  Ser Ile Lys Gln Asn  Glu Phe Phe Val Phe  Pro Ser Gln 
    1250                 1255                 1260             


Asp Phe  Asn Pro Asn Asp Phe  Asp Leu Leu Asp Pro  Lys Asn Tyr 
    1265                 1270                 1275             


Asp Leu  Ile Ser Pro Asn Leu  Tyr Arg Ala Gln Lys  Phe Ser Lys 
    1280                 1285                 1290             


Val Met  Tyr Gly Asn Ser Ala  Val Arg Asp Tyr Val  Phe Arg His 
    1295                 1300                 1305             


His Leu  Glu Thr Val Leu Asn  Asp Val Lys Glu Leu  Lys Asp Val 
    1310                 1315                 1320             


Ala Tyr  Lys Gln Leu Lys Ser  Leu Gln Tyr Leu Asn  Gly Ile Lys 
    1325                 1330                 1335             


Lys Val  Arg Leu Asn His Leu  Gly Gln Ile Ile Gln  Val Gly Glu 
    1340                 1345                 1350             


Tyr 
    


<210> 261
<211> 1397
<212> PRT
<213> Joostella marina


<220>
<223> Joostella marina DSM 19592

<400> 261
Met Lys Lys Val Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Thr Lys Glu Glu Lys Lys Glu Gly Lys Ser 
            20                  25                  30          


Ser Glu Ile Ile Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp 
        35                  40                  45              


Glu Lys Thr Asn Phe Glu Lys Gly Arg Pro Leu Ser Thr Asn Ala Asp 
    50                  55                  60                  


Arg Thr Leu Lys Arg Ser Ala Arg Arg Asn Leu Gln Arg Tyr Lys Leu 
65                  70                  75                  80  


Arg Arg Arg Asn Leu Ile Glu Ile Leu Ile Lys Asn Gly Phe Ile Thr 
                85                  90                  95      


Lys Asp Thr Pro Leu Thr Glu Thr Gly Lys Asp Thr Thr His Gln Thr 
            100                 105                 110         


Leu Lys Leu Arg Ala Lys Ser Ala Lys Glu Lys Val Asp Leu Lys Asp 
        115                 120                 125             


Phe Ala Lys Ile Leu Leu Thr Ile Asn Lys Lys Arg Gly Tyr Lys Ser 
    130                 135                 140                 


Ser Arg Lys Val Asn Ser Asp Glu Asp Gly Leu Ala Ile Asp Gly Met 
145                 150                 155                 160 


Ala Val Ala Lys His Leu Tyr Glu Gln Asn Leu Thr Pro Gly Gln Tyr 
                165                 170                 175     


Val Leu Asn Leu Leu Gln Lys Asn Lys Lys Tyr Val Pro Asp Phe Tyr 
            180                 185                 190         


Arg Ser Asp Leu Gln Glu Glu Phe Lys Asn Ile Trp Asn Asn Gln Lys 
        195                 200                 205             


Thr Tyr Tyr Phe Asp Ile Leu Thr Asp Thr Leu Phe Glu Glu Leu Lys 
    210                 215                 220                 


Asp Lys Asn Lys Ser Gln Thr Trp Ala Ile Cys Lys Lys Pro Phe Asp 
225                 230                 235                 240 


Ile Ala Gly Ile Lys Gln Ile Gly Lys Ala Ser Asp Lys Arg Leu Glu 
                245                 250                 255     


Arg Tyr Lys Trp Arg Thr Glu Gly Leu Thr Gln Lys Leu Asn Leu Glu 
            260                 265                 270         


Tyr Leu Ala Ile Ala Leu Gln Glu Ile Asn Asn Asp Ile Asn Lys Ser 
        275                 280                 285             


Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Phe Phe 
    290                 295                 300                 


Asn Lys Glu Thr Val Gly Glu Asn Leu Tyr Arg Gln Leu Val Lys Thr 
305                 310                 315                 320 


Pro His Thr Ser Leu Arg Asn Gln Val Phe Tyr Arg Gln Asp Tyr Leu 
                325                 330                 335     


Asp Glu Phe Glu Thr Ile Trp Glu Thr Gln Ala Lys Phe Tyr Pro Gln 
            340                 345                 350         


Leu Thr His Thr Leu Lys Glu Glu Ile Arg Asp Val Ile Ile Phe Tyr 
        355                 360                 365             


Gln Arg Lys Leu Lys Ser Gln Lys Ser Leu Ile Ser Phe Cys Gln Phe 
    370                 375                 380                 


Glu Ser Trp Glu Gln Thr Tyr Ile Glu Lys Glu Thr Gly Lys Ser Lys 
385                 390                 395                 400 


Thr Arg Thr Val Gly Arg Lys Val Ile Pro Lys Ser Ser Pro Leu Phe 
                405                 410                 415     


Gln Glu Phe Lys Ile Trp Gln Asn Leu Asn Ser Leu Glu Phe Arg Asn 
            420                 425                 430         


Ser Asp Glu Gly Glu Ile Ile Glu Phe Ile Lys Leu Asp Glu Asp Ile 
        435                 440                 445             


Arg Gln Thr Val Phe Glu Glu Leu Asn Leu Arg Gly Asn Leu Lys Pro 
    450                 455                 460                 


Asn Asp Val Leu Lys Ile Leu Gly Asn Tyr Ile Ser Leu Gly Lys Val 
465                 470                 475                 480 


Ser Gln Trp Lys Cys Asn Phe Glu Glu Ile Glu Gly Asn Arg Thr Asn 
                485                 490                 495     


Ala Ala Leu Tyr Asn Val Tyr Gln Ile Ile Ala Glu Asn Glu Gly Tyr 
            500                 505                 510         


Gly Phe Asp Trp Ala Lys Lys Thr Ala Ser Glu Ile Asn Lys Glu Leu 
        515                 520                 525             


Lys Asn Ile Phe Pro Gln Leu Gly Ile Asp Ala Ser Ile Leu Asp Phe 
    530                 535                 540                 


Asp Phe Thr Gln Ala Asn Phe Asp Lys Gln Thr Ser Tyr Gln Leu Trp 
545                 550                 555                 560 


His Leu Leu Tyr Ser Ala Glu Glu Asp Phe Lys Ile Ser Glu Glu Asp 
                565                 570                 575     


Lys Val Leu Tyr Gly Asn Ser Ser Val Ser Leu Lys Lys Lys Leu His 
            580                 585                 590         


Gln Lys Tyr Gly Phe Lys Pro Glu Tyr Thr Lys Leu Leu Thr Asn Ile 
        595                 600                 605             


Ser Leu Gln Pro Asp Tyr Gly Asn Leu Ser Ala Lys Ala Ile Cys Asn 
    610                 615                 620                 


Ile Leu Pro Tyr Leu Lys Glu Asn Asn Val Tyr Ser Glu Ala Cys Asp 
625                 630                 635                 640 


Leu Thr Gly Tyr Asn His Ser Asn Phe Leu Thr Ala Glu Glu Gln Ala 
                645                 650                 655     


Lys Arg Pro Leu Lys Pro Ile Leu Glu Leu Leu Lys Lys Asn Ser Leu 
            660                 665                 670         


Arg Asn Pro Val Val Glu Lys Ile Leu Asn Gln Met Val Asn Val Val 
        675                 680                 685             


Asn Gln Val Ile Glu Thr Tyr Gly Lys Pro Asp Glu Ile Arg Ile Glu 
    690                 695                 700                 


Leu Thr Arg Glu Leu Lys Lys Ser Ala Lys Glu Arg Ala Asn Met Thr 
705                 710                 715                 720 


Lys Ser Ile Ala Asp Ala Thr Arg Arg Asn Asp Asp Tyr Arg Lys Thr 
                725                 730                 735     


Ile Ile Lys Glu Phe Gly Ile Pro Asn Pro Thr Lys Ser Asp Val Val 
            740                 745                 750         


Arg Tyr Arg Leu Trp Gln Glu Leu Ala Ser Arg Gly Tyr Lys Asp Ile 
        755                 760                 765             


Phe Thr Asp Thr Glu Ile Lys Pro Gln Glu Leu Phe Ser Asn Lys Ile 
    770                 775                 780                 


Asp Ile Glu His Ile Ile Pro Lys Ala Leu Leu Phe Asp Asp Ser Phe 
785                 790                 795                 800 


Ser Asn Lys Thr Leu Ala Phe Lys Lys Asp Asn Leu Lys Lys Ala Asn 
                805                 810                 815     


Arg Thr Ala Tyr Asp Phe Ile Ala Asn Asp Tyr Ala Pro Asn Leu Glu 
            820                 825                 830         


Asn Tyr Ile Glu Arg Val Glu Ser Leu His Lys Asp Arg Lys Ile Thr 
        835                 840                 845             


Arg Ala Lys Arg Asn Lys Leu Leu Met Leu Gln Ser Lys Leu Pro Asp 
    850                 855                 860                 


Gly Phe Ile Glu Arg Asp Leu Arg Asn Ser Gln Tyr Ile Thr Lys Glu 
865                 870                 875                 880 


Ala Lys Lys Met Leu Tyr Glu Val Cys Arg Thr Val Val Ser Thr Ser 
                885                 890                 895     


Gly Ser Ile Thr Asp Lys Leu Arg Glu Asp Trp Asp Leu Ile Asn Val 
            900                 905                 910         


Met Lys Glu Leu Asn Phe Pro Lys Tyr Lys Ala Leu Gly Leu Thr Glu 
        915                 920                 925             


Lys Ile Glu Arg Tyr Asp Ile Gly Ala Glu Lys Met Lys Glu Val Glu 
    930                 935                 940                 


Ile Ile Glu Asp Trp Asn Lys Arg Asn Asp His Arg His His Ala Ile 
945                 950                 955                 960 


Asp Ala Leu Thr Val Ala Phe Ser Thr His Ser His Ile Gln Tyr Leu 
                965                 970                 975     


Asn His Leu Asn Ala Arg Arg Asp Glu Gly His Lys Lys His Ala Ala 
            980                 985                 990         


Ile Ile Ala Ile Glu Ser Thr Ile  Thr Glu Lys Glu Gly  Asn Lys Lys 
        995                 1000                 1005             


Arg Arg  Phe Ile Ala Pro Leu  Pro Asn Phe Arg Leu  Gln Ala Lys 
    1010                 1015                 1020             


Glu His  Ile Glu Ser Ile Leu  Val Ser Phe Lys Asn  Lys Asn Lys 
    1025                 1030                 1035             


Val Val  Thr Asn Asn Ile Asn  Lys Thr Lys Arg Ile  Lys Lys Asp 
    1040                 1045                 1050             


Lys Phe  Asn Thr Lys Val Gln  Leu Thr Pro Arg Gly  Gln Leu His 
    1055                 1060                 1065             


Lys Glu  Thr Ile Tyr Gly Lys  Ile Lys Gln Pro Leu  Glu Lys His 
    1070                 1075                 1080             


Ile Lys  Leu Asn Lys Ser Phe  Thr Leu Glu Gln Ala  Lys Leu Ile 
    1085                 1090                 1095             


Ile Asp  Lys Arg Gln Arg Glu  Lys Val Leu Asn His  Leu Glu Lys 
    1100                 1105                 1110             


Tyr Ala  His Asn Ser Asp Ile  Ala Phe Asn Ser Lys  Thr Leu Lys 
    1115                 1120                 1125             


Lys Asn  Pro Leu Leu Ile Ser  Asp Glu Pro Leu Lys  Glu Val Leu 
    1130                 1135                 1140             


Cys Phe  Glu Glu Val Phe Thr  Ile Arg Lys Asp Ile  Ser Tyr Asp 
    1145                 1150                 1155             


Asn Phe  Lys Asn Glu Lys Gln  Leu Asp Lys Val Ile  Asp Glu Lys 
    1160                 1165                 1170             


Val Lys  Gln Ala Leu Lys Glu  Arg Ile Asn Gln Tyr  Asn Gly Asp 
    1175                 1180                 1185             


Phe Arg  Glu Ala Phe Ser Asp  Ile Glu Arg Asn Pro  Ile Trp Leu 
    1190                 1195                 1200             


Asn Lys  Ala Lys Gly Ile Cys  Val Lys Arg Ala Thr  Ile Lys Gly 
    1205                 1210                 1215             


Val Ser  Asn Ala Glu Pro Leu  His Thr Ala Lys Asn  His Leu Gly 
    1220                 1225                 1230             


Glu Glu  Val Leu Thr Glu Asn  Lys Glu Gln Ile Pro  Val Asp Tyr 
    1235                 1240                 1245             


Val Ser  Thr Gly Asn Asn His  His Val Ala Ile Tyr  Glu Asp Glu 
    1250                 1255                 1260             


Asp Gly  Asn Leu Gln Glu Lys  Val Val Ser Phe Tyr  Glu Ala Val 
    1265                 1270                 1275             


Ile Arg  Val Asn Glu Gly Leu  Pro Ile Ile Asp Lys  Glu Tyr Asn 
    1280                 1285                 1290             


Lys Ser  Leu Gly Trp Thr Phe  Lys Phe Thr Met Lys  Gln Asn Glu 
    1295                 1300                 1305             


Met Phe  Val Phe Pro Ser Glu  Asp Phe Asn Pro Thr  Glu Ile Asp 
    1310                 1315                 1320             


Leu Leu  Asp Gln Lys Asn Ala  Ser Leu Ile Ser Pro  Asn Leu Phe 
    1325                 1330                 1335             


Arg Val  Gln Lys Phe Thr Ile  Lys Asp Tyr Phe Phe  Arg His His 
    1340                 1345                 1350             


Leu Glu  Thr Thr Val Glu Asn  Asn Asn Thr Leu Lys  Asn Thr Thr 
    1355                 1360                 1365             


Trp Arg  Arg Glu Gly Leu Ser  Gly Ile Tyr Gly Ile  Ile Lys Ile 
    1370                 1375                 1380             


Arg Leu  Asn His Leu Gly Glu  Ile Val Gln Val Gly  Glu Tyr 
    1385                 1390                 1395         


<210> 262
<211> 1060
<212> PRT
<213> Kingella kingae


<220>
<223> Kingella kingae PYKK081

<400> 262
Met Ala Ala Lys Ser Leu Asn Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Cys Gly Trp Ala Val Val Glu Met Asp Glu Gln Glu Asn Pro 
            20                  25                  30          


Leu Arg Leu Ile Asp Val Gly Val Arg Thr Phe Glu Glu Ala Glu Asn 
        35                  40                  45              


Pro Lys Asp Gly Ser Ser Leu Ala Glu Thr Arg Arg Leu Ala Arg Ala 
    50                  55                  60                  


Gln Arg Arg Leu Ile Ser Arg Arg Ala Asn Arg Met Asn Lys Leu Cys 
65                  70                  75                  80  


Arg Leu Leu Lys Gln Glu Asn Val Leu Gln Ala Asn Asp Tyr Asp Glu 
                85                  90                  95      


Lys Gly Leu Ile Ile Gly Leu Pro Asn Gln Ala Trp Glu Leu Arg Ala 
            100                 105                 110         


Gln Gly Leu Asp Arg Lys Leu Glu Pro Lys Glu Trp Ala Ala Val Leu 
        115                 120                 125             


Ile His Leu Val Lys His Arg Gly Tyr Leu Ser Gln Arg Lys Asn Glu 
    130                 135                 140                 


Ser Gln Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Ser Gly Met Asn 
145                 150                 155                 160 


His Asn His Gln Leu Leu Gln Ser Gln Ser Asn Gln Tyr Arg Thr Pro 
                165                 170                 175     


Ala Glu Leu Ala Ile Lys Gln Phe Ala Thr Gln Asp Gly His Ile Arg 
            180                 185                 190         


Asn Gln Arg Gly Ala Tyr Thr His Thr Phe Asn Arg Leu Asp Leu Gln 
        195                 200                 205             


Asn Glu Leu Asn Gln Leu Phe Asp Ala Gln Thr Arg Leu Gly Asn Pro 
    210                 215                 220                 


His Val Ser Gly Ser Leu Lys Thr Ala Ile Asn Asp Leu Leu Met Asn 
225                 230                 235                 240 


Gln Lys Ala Ala Leu Ser Gly Asp Ala Ile Leu Glu Met Leu Gly Arg 
                245                 250                 255     


Cys Thr Phe Glu Pro Ser Glu Tyr Lys Ala Ala Lys Asn Thr Tyr Ser 
            260                 265                 270         


Ala Glu Arg Phe Val Trp Leu Gly Lys Leu Thr Asn Leu Arg Ile Gln 
        275                 280                 285             


Asp Asn Gly Leu Glu Ser Ala Leu Ser Arg Glu Gln Arg Glu Leu Leu 
    290                 295                 300                 


Leu Asn Glu Pro Tyr Asn Lys Thr Lys Leu Thr Tyr Gln Gln Val Arg 
305                 310                 315                 320 


Lys Leu Leu Arg Leu Pro Glu Thr Ala Phe Phe Lys Gly Leu Arg Tyr 
                325                 330                 335     


Gly Lys Asp Asn Ala Glu Ser Ala Thr Phe Met Glu Met Lys Ser Tyr 
            340                 345                 350         


His Ala Ile Arg Lys Ser Leu Glu Asn Lys Ser Leu Lys Ser Glu Trp 
        355                 360                 365             


Glu Lys Leu Lys Thr Gln Pro Lys Leu Leu Asp Leu Ile Gly Thr Ala 
    370                 375                 380                 


Phe Ser Ile Tyr Lys Thr Asp Asp Glu Ile Ala Gly Cys Leu Lys Asn 
385                 390                 395                 400 


Gln Leu Pro Glu Asn Val Ile Ile Ala Leu Gln Gly Gln Leu Asn Phe 
                405                 410                 415     


Ser Asn Phe Met Glu Leu Ser Leu Lys Ala Leu Glu Lys Leu Leu Pro 
            420                 425                 430         


Leu Met Glu Gln Gly Leu Arg Tyr Asp Glu Ala Cys Thr Gln Ile Tyr 
        435                 440                 445             


Gly Asn Arg His Glu Lys Ile Ala Asp Lys Thr Glu Lys Phe Leu Pro 
    450                 455                 460                 


Asn Ile Pro Ala Asp Lys Leu Arg Asn Pro Val Val Leu Arg Thr Leu 
465                 470                 475                 480 


Thr Gln Ala Arg Lys Val Ile Asn Ala Ile Ile Arg Arg Tyr Gly Ser 
                485                 490                 495     


Pro Ala Arg Val His Ile Glu Thr Gly Arg Glu Val Gly Lys Ser Phe 
            500                 505                 510         


Ser Asp Arg Asp Lys Leu Lys Lys Gln Gln Glu Glu Asn Gln Glu Gln 
        515                 520                 525             


Arg Arg Arg Ala Ile Asp Glu Trp Lys Gln Phe Phe Pro Asn Ala Ala 
    530                 535                 540                 


His Glu Pro Lys Ala Val Asp Ile Leu Lys Leu Arg Leu Tyr Gln Leu 
545                 550                 555                 560 


Gln Gln Gly Lys Cys Leu Tyr Ser Gly Leu Pro Ile Asp Val Arg Arg 
                565                 570                 575     


Leu Pro Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe Ser 
            580                 585                 590         


Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Ile Leu Val Leu Ala Ser 
        595                 600                 605             


Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Leu Arg Gly 
    610                 615                 620                 


Ala Asp Asn Ser Glu Ser Trp Arg Leu Phe Val Glu Asn Val Gln Asn 
625                 630                 635                 640 


Cys Gln Phe Ser Pro Asn Lys Lys Gln Lys Ile Met Ala Lys Gln Leu 
                645                 650                 655     


Asp Glu Lys Gly Phe Leu Glu Arg Asn Leu Asn Asp Thr Arg Tyr Val 
            660                 665                 670         


Ser Arg Phe Leu Cys Gln Phe Ile Ser Glu His Leu His Leu Thr Gly 
        675                 680                 685             


Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Ala Leu 
    690                 695                 700                 


Leu Arg Gly Arg Trp Gly Leu Ser Lys Asn Arg Glu Glu Asn Asp Arg 
705                 710                 715                 720 


His His Ala Val Asp Ala Val Val Val Ala Cys Ser Thr Val Ala Met 
                725                 730                 735     


Gln Gln Lys Ile Thr Gln Phe Val Arg Tyr Gln Lys Gly Asn Val Phe 
            740                 745                 750         


Thr Gly Glu Arg Ile Asp Lys Glu Thr Gly Glu Val Ile Ser Ile His 
        755                 760                 765             


Phe Pro Thr Pro Trp Glu His Phe Arg Glu Glu Val Met Ile Arg Val 
    770                 775                 780                 


Phe Asp Asp Asn Pro Leu Arg Thr Leu Pro Glu Lys Leu Pro Asn Arg 
785                 790                 795                 800 


Pro Glu Ala Leu His Glu Tyr Val Met Pro Leu Phe Val Ser Arg Met 
                805                 810                 815     


Pro Thr Arg Lys Met Thr Gly Gln Gly His Lys Glu Thr Ile Lys Ser 
            820                 825                 830         


Ala Lys Arg Leu Asp Glu Lys Ile Ser Val Leu Arg Val Pro Leu Thr 
        835                 840                 845             


Gln Leu Lys Leu Asn Asp Leu Glu Asn Met Val Asn Arg Glu Arg Glu 
    850                 855                 860                 


Pro Ala Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Gln Phe Lys Asn 
865                 870                 875                 880 


Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Phe Lys Gln Gly Gly Gln 
                885                 890                 895     


Gln Val Lys Ala Val Arg Val Glu Ile Val Gln Lys Ser Gly Met Leu 
            900                 905                 910         


Leu Arg Lys Ile Asn Gly Val Ala Asp Asn Gly Ser Met Val Arg Val 
        915                 920                 925             


Asp Val Phe Glu Lys Ser Gly Lys Phe Tyr Leu Val Pro Ile Tyr Ala 
    930                 935                 940                 


Trp Gln Val Ala Glu Gly Ile Leu Pro Asn Tyr Ala Val Val Ala His 
945                 950                 955                 960 


Lys Asp Glu Ser Asp Trp Ile Leu Met Asp Glu Ser Tyr His Phe Lys 
                965                 970                 975     


Phe Ala Leu Tyr Lys Asn Asp Leu Leu Glu Val Gln Thr Lys Lys Gly 
            980                 985                 990         


Gly Ile Met Gly Tyr Phe Ala Ser  Leu Asp Arg Ala Thr  Gly Ala Ile 
        995                 1000                 1005             


Thr Ile  Arg Glu His Asp Arg  Asp Lys Lys Lys Cys  Lys Asp Gly 
    1010                 1015                 1020             


Glu His  Arg Ser Ile Gly Val  Lys Met Ala Ser Ser  Phe Lys Lys 
    1025                 1030                 1035             


Leu Gln  Val Asp Glu Leu Gly  Lys Asn Ile His Glu  Thr Arg Ser 
    1040                 1045                 1050             


Arg Lys  Arg Pro Asn Ile Gly  
    1055                 1060 


<210> 263
<211> 1391
<212> PRT
<213> Kordia algicida


<220>
<223> Kordia algicida OT-1

<400> 263
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Glu His Glu His Glu Gln Ser Ser Ile Val 
            20                  25                  30          


Lys Leu Gly Val Arg Val Asn Pro Leu Ser Val Asp Glu Lys Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Arg Pro Leu Ser Ile Asn Ala Asp Arg Thr Ser Lys 
    50                  55                  60                  


Arg Ser Ala Arg Arg Asn Leu Gln Arg Phe Lys Leu Arg Arg Lys Asn 
65                  70                  75                  80  


Leu Ile Asn Leu Leu Leu Lys His His Ile Ile Ser Asn Glu Thr Ile 
                85                  90                  95      


Leu Thr Glu Val Gly Lys Asn Thr Thr His Gln Thr Leu Lys Leu Arg 
            100                 105                 110         


Ser Lys Ala Thr Gln Glu Lys Ile Ser Leu Glu Glu Phe Ala Arg Ile 
        115                 120                 125             


Leu Leu Ser Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Glu 
    130                 135                 140                 


Lys Asn Glu Asp Glu Gly Phe Thr Ile Asp Gly Met Ala Ile Ala Lys 
145                 150                 155                 160 


Glu Leu Tyr Asp Asn Gln Leu Thr Pro Gly Gln Tyr Val Tyr Asn Ile 
                165                 170                 175     


Leu Gln Asp Gly Lys Asn Tyr Ile Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Ala Glu Phe Asp Asp Val Trp Gln Phe Gln Lys Lys Phe Tyr Ser 
        195                 200                 205             


Ser Ile Leu Thr Asp Glu Phe Tyr Leu Lys Leu Lys Gly Gln Gly Lys 
    210                 215                 220                 


Glu Asn Thr Arg Lys Leu Phe Leu Ala Ile His Gln Val Tyr Thr Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Lys Arg Asp Ala Val Lys Leu Gln Tyr Tyr Lys Trp 
                245                 250                 255     


Arg Ser Glu Ala Val Lys Lys Gln Leu Ser Ile Glu Glu Val Ala Tyr 
            260                 265                 270         


Val Leu Val Glu Ile Asn Asn Asn Ile Asn Lys Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Ala Leu Tyr Phe Asn Asn Glu Thr 
    290                 295                 300                 


Val Gly Glu Tyr Leu Tyr Gly Gln Leu Val Lys Asn Arg His Asn Ser 
305                 310                 315                 320 


Leu Arg Asn Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Lys Ile Trp Glu Thr Gln Ala Lys Phe Tyr Asp Glu Leu Thr Asn Glu 
            340                 345                 350         


Leu Lys Gln Glu Ile Arg Asp Val Val Ile Phe Tyr Gln Arg Lys Leu 
        355                 360                 365             


Lys Ser Gln Lys His Leu Ile Ser Asp Cys Leu Phe Glu Lys His His 
    370                 375                 380                 


Lys Ala Ile Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp 
385                 390                 395                 400 


Gln Asn Leu Asn Tyr Leu Glu Phe Val His Thr Gln Ser Lys Glu Lys 
                405                 410                 415     


Ile Phe Phe Ser Glu Leu Asp Asp Glu Thr Arg Gln Phe Val Phe Ala 
            420                 425                 430         


Glu Leu Asn Ile Arg Gly Thr Leu Lys Ile Lys Glu Ile Lys Lys Leu 
        435                 440                 445             


Ile Gly Leu Glu Thr Pro Val Tyr Trp Lys Ser Asn Phe Asp Glu Ile 
    450                 455                 460                 


Glu Gly Asn Arg Thr Asn Gln Val Leu Tyr Asn Val Tyr Gln Asn Ile 
465                 470                 475                 480 


Ala Asp Asp Leu Gly Tyr Gly Phe Asp Trp Ser Lys Lys His Ala Phe 
                485                 490                 495     


Glu Ile Asn Ala Glu Leu Gln Ala Ile Phe Lys Asp Val Gly Ile Asp 
            500                 505                 510         


Thr Ala Ile Leu Asn Phe Asp Ala Ser Ile Glu Glu Asn Asp Phe Asp 
        515                 520                 525             


Lys Gln Lys Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser Ala Glu Asp 
    530                 535                 540                 


Thr Asp Lys Ala Thr Glu Glu Asp Lys Leu Ile Tyr Gly Asn Ile Asn 
545                 550                 555                 560 


Thr Lys Leu Lys Lys Gln Leu His Gln Lys Tyr Gly Phe Glu Ala Lys 
                565                 570                 575     


Tyr Gly Asn Leu Leu Ala Asn Ile Ser Leu Gln Gln Asp Tyr Gly Asn 
            580                 585                 590         


Leu Ser Ala Lys Ala Ile Lys Lys Ile Leu Pro Tyr Leu Glu Ser Gly 
        595                 600                 605             


Asn Ser Phe Tyr Glu Ala Cys Thr Ile Val Gly Tyr Asn Pro Ser Asn 
    610                 615                 620                 


Ser Leu Thr Lys Glu Gln Gln Gln Asn Arg Lys Leu Lys Asp Lys Leu 
625                 630                 635                 640 


Glu Leu Leu Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile 
                645                 650                 655     


Leu Asn Gln Lys Val Asn Leu Ile Asn Gln Leu Ile Asp Glu Tyr Gly 
            660                 665                 670         


Lys Pro Asp Glu Val Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Ser 
        675                 680                 685             


Ala Lys Gln Arg Ala Asp Leu Ser Lys His Ile Asn Asp Ala Thr Leu 
    690                 695                 700                 


Lys Asn Gln Asn Ile Arg Lys Thr Leu Gln Lys Asp Phe Gly Ile Gln 
705                 710                 715                 720 


Asn Pro Ser Lys Asn Asp Val Ile Arg Tyr Lys Leu Tyr Asp Glu Leu 
                725                 730                 735     


Lys Asp Asn Gly Tyr Lys Thr Leu Phe Thr Asn Lys Tyr Ile Pro Lys 
            740                 745                 750         


Glu Gln Leu Phe Ser Lys Asp Val Asp Ile Glu His Ile Ile Pro Lys 
        755                 760                 765             


Ala Ile Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Ala Tyr Arg 
    770                 775                 780                 


Asn Val Asn Leu Ala Lys Ala Asp Ala Thr Ala Phe Asp Phe Ile Ser 
785                 790                 795                 800 


Ser Lys His Leu Asp Asp Leu Asp Asn Tyr Lys Ala Arg Val Glu Thr 
                805                 810                 815     


Leu Phe Gln Ser Lys Arg Ile Ser Lys Gly Lys Tyr Lys Lys Leu Leu 
            820                 825                 830         


Met Thr Arg Gln Asn Leu Pro Glu Asp Phe Ile Glu Arg Asp Leu Arg 
        835                 840                 845             


Asn Ser Gln Tyr Ile Ala Lys Lys Ala Thr Ala Met Leu Lys Glu Val 
    850                 855                 860                 


Phe Arg Ser Val Val Pro Thr Ser Gly Arg Ile Thr Asp Lys Leu Arg 
865                 870                 875                 880 


Glu Asp Trp Asp Leu Val Asn Val Met Lys Glu Leu Asn Leu Pro Lys 
                885                 890                 895     


Tyr Arg Thr Leu Gly Leu Thr Glu Phe Ile Glu Arg Lys Asn Gly Asn 
            900                 905                 910         


Lys Ile Glu Gln Ile Ile Asp Trp Thr Lys Arg Asn Asp His Arg His 
        915                 920                 925             


His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Thr His Asn His Ile 
    930                 935                 940                 


Gln Tyr Leu Asn Asn Leu Asn Val Thr His Gly Leu Asn Gly Val Asp 
945                 950                 955                 960 


Thr Asp His Glu Lys Ser Arg Leu Tyr Ala Ile Lys Gln Ala Ile Thr 
                965                 970                 975     


Lys Val Tyr Ile Val Gly Lys Thr Lys Lys Arg Lys Phe Ile Pro Pro 
            980                 985                 990         


Met Glu Asn Phe Arg Ser His Ala  Lys Asn His Leu Glu  Gly Ile Leu 
        995                 1000                 1005             


Ile Ser  Phe Lys Asn Lys Asn  Lys Val Val Thr Lys  Asn Lys Asn 
    1010                 1015                 1020             


Arg Thr  Lys Thr Lys Thr Lys  Gly Val Phe Asn Glu  Lys Ile Gln 
    1025                 1030                 1035             


Leu Thr  Pro Arg Gly Gln Leu  His Lys Glu Thr Ile  Tyr Gly His 
    1040                 1045                 1050             


Ala Lys  Lys Val Ile Val Thr  Lys Glu Lys Val Ser  Ser Lys Phe 
    1055                 1060                 1065             


Thr His  Glu Lys Ile Leu Gln  Val Thr Lys Pro Ala  Tyr Arg Glu 
    1070                 1075                 1080             


Ala Leu  Leu Lys Arg Leu Ala  Ser Phe Lys Asn Asp  Pro Lys Lys 
    1085                 1090                 1095             


Ala Phe  Ser Gly Lys Asn Ala  Leu Ser Lys Asn Pro  Leu Tyr Phe 
    1100                 1105                 1110             


Asp Ile  Thr Ser Gly Lys Lys  Val Pro Asp Thr Val  Lys Leu Ser 
    1115                 1120                 1125             


Tyr Phe  Glu Asn Ser Tyr Val  Ile Arg Lys Glu Val  Asn Ser Asp 
    1130                 1135                 1140             


Asn Phe  Lys Asn Glu Lys Ser  Leu Gln Lys Val Leu  Asp Val Gly 
    1145                 1150                 1155             


Ile Arg  Arg Ile Leu Glu Lys  Arg Leu Ala Asp Tyr  Asn Gly Asn 
    1160                 1165                 1170             


Ala Lys  Glu Ala Phe Ser Asn  Leu Glu Lys Asn Pro  Ile Trp Lys 
    1175                 1180                 1185             


Asp Lys  Glu Lys Gly Val Cys  Ile Lys Lys Val Arg  Ile Glu Ala 
    1190                 1195                 1200             


Leu Lys  Asn Ala Glu Pro Leu  His Val Lys Lys Asp  His Leu Gly 
    1205                 1210                 1215             


Lys Ile  Ile Leu Asp Asp Glu  Asn Lys Ser Thr Pro  Val Asp Phe 
    1220                 1225                 1230             


Ile Ser  Thr Gly Asn Asn His  His Val Ala Ile Tyr  Glu Asp Lys 
    1235                 1240                 1245             


Asp Gly  Lys Leu His Asp Lys  Val Val Ser Phe Tyr  Glu Val Val 
    1250                 1255                 1260             


Ser Arg  Val Asn Leu Gly Leu  Pro Ile Ile Asp Lys  Ser Phe Asn 
    1265                 1270                 1275             


Ser His  Leu Asp Trp Lys Phe  Leu Phe Ser Met Lys  Gln Asn Glu 
    1280                 1285                 1290             


Met Phe  Val Phe Pro Ser Glu  Asp Phe Asn Pro Lys  Glu Ile Asp 
    1295                 1300                 1305             


Ile Gly  Asn Pro Lys Asn Asn  Glu Leu Ile Ser Lys  Tyr Leu Phe 
    1310                 1315                 1320             


Arg Val  Gln Lys Phe Ser Lys  Val Thr Tyr Gly Asn  Ser Ala Val 
    1325                 1330                 1335             


Arg Asp  Tyr Val Phe Arg His  His Leu Glu Thr Glu  Leu Ile Asp 
    1340                 1345                 1350             


Lys Lys  Glu Leu Lys Gly Ile  Thr Tyr Tyr Gln Leu  Lys Ser Ile 
    1355                 1360                 1365             


Gly Met  Leu Glu Lys Leu Val  Lys Val Arg Ile Asn  His Ile Gly 
    1370                 1375                 1380             


Lys Ile  Val His Ile Gly Glu  Tyr 
    1385                 1390     


<210> 264
<211> 1314
<212> PRT
<213> Lactobacillus animalis


<220>
<223> Lactobacillus animalis KCTC 3501

<400> 264
Met Leu Lys Lys Asp Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly His Ala Val Val Thr Asp Asp Tyr Lys Val Pro Thr Lys Lys 
            20                  25                  30          


Met Lys Val Phe Gly Asp Thr Ser Lys Lys Thr Ile Lys Lys Asn Met 
        35                  40                  45              


Leu Gly Val Leu Leu Phe Asn Glu Gly Gln Thr Ala Ala Asp Thr Arg 
    50                  55                  60                  


Leu Lys Arg Gly Thr Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Pro Glu Leu Ala Lys Val Asp Pro 
                85                  90                  95      


Asn Phe Leu Tyr Arg Leu Glu Glu Ser Ser Leu Val Ala Glu Asp Lys 
            100                 105                 110         


Lys Tyr Asp Val Tyr Pro Ile Phe Gly Lys Arg Glu Glu Glu Leu Leu 
        115                 120                 125             


Tyr His Asp Thr Tyr Lys Thr Ile Tyr His Leu Arg Ser Ala Leu Ala 
    130                 135                 140                 


Asn Asn Asp Gln Pro Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Ile Ile Lys Tyr Arg Gly Asn Phe Leu Leu Glu Gly Glu Ile Asp 
                165                 170                 175     


Leu Arg Thr Thr Asp Ile Asn Lys Val Phe Ala Glu Phe Ser Glu Thr 
            180                 185                 190         


Leu Asn Glu Asn Ser Asp Glu Asn Leu Gly Lys Leu Asp Val Ala Asp 
        195                 200                 205             


Ile Phe Lys Asn Asn Thr Phe Ser Lys Thr Lys Lys Ser Glu Glu Leu 
    210                 215                 220                 


Leu Lys Leu Ser Gly Ala Lys Lys Asn Gln Leu Ala His Gln Leu Phe 
225                 230                 235                 240 


Lys Met Met Val Gly Asn Met Gly Ser Phe Lys Lys Val Leu Gly Thr 
                245                 250                 255     


Asp Glu Glu His Lys Leu Ser Phe Gly Lys Asp Thr Tyr Glu Asp Asp 
            260                 265                 270         


Leu Asn Asp Leu Leu Ala Glu Ala Gly Asp Gln Tyr Leu Asp Ile Phe 
        275                 280                 285             


Val Ala Ala Lys Lys Val Tyr Asp Ala Ala Ile Leu Ala Ser Ile Leu 
    290                 295                 300                 


Asp Val Lys Asp Thr Gln Thr Lys Thr Val Phe Ser Gln Ala Met Ile 
305                 310                 315                 320 


Glu Arg Tyr Glu Glu His Gln Lys Asp Leu Ile Glu Leu Lys Arg Val 
                325                 330                 335     


Phe Lys Lys Tyr Leu Pro Glu Lys Cys His Asp Phe Phe Ser Glu Pro 
            340                 345                 350         


Lys Ile Ser Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Val Ser Glu Glu 
        355                 360                 365             


Asp Phe Tyr Lys Tyr Thr Lys Lys Thr Leu Lys Gly Ile Pro Glu Thr 
    370                 375                 380                 


Glu Glu Ile Leu Gln Lys Ile Asp Ala Asn Asn Tyr Leu Arg Lys Gln 
385                 390                 395                 400 


Arg Thr Phe Asp Asn Gly Ala Ile Pro His Gln Val His Leu Lys Glu 
                405                 410                 415     


Leu Val Ala Ile Val Glu Asn Gln Gly Lys Tyr Tyr Pro Phe Leu Arg 
            420                 425                 430         


Glu Asn Lys Asp Lys Phe Glu Lys Ile Leu Asn Phe Arg Ile Pro Tyr 
        435                 440                 445             


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Lys Phe Ala Trp Leu Thr 
    450                 455                 460                 


Arg Ala Gly Glu Gly Lys Ile Thr Pro Tyr Asn Phe Asp Glu Met Ile 
465                 470                 475                 480 


Asp Lys Glu Thr Ser Ala Glu Asp Phe Ile Lys His Met Thr Ile Asn 
                485                 490                 495     


Asp Leu Tyr Leu Pro Thr Glu Pro Val Leu Pro Lys His Ser Leu Leu 
            500                 505                 510         


Tyr Glu Arg Tyr Thr Ile Phe Asn Glu Leu Ala Gly Val Arg Tyr Val 
        515                 520                 525             


Thr Glu Asn Gly Glu Ala Lys Tyr Phe Asp Ala Gln Thr Lys Arg Ser 
    530                 535                 540                 


Ile Phe Glu Leu Phe Lys Leu Asp Arg Lys Val Ser Glu Lys Met Val 
545                 550                 555                 560 


Ile Lys His Leu Lys Val Val Met Pro Ala Ile Arg Ile Gln Ala Leu 
                565                 570                 575     


Lys Gly Leu Asp Asn Gly Lys Phe Asn Ala Ser Tyr Gly Thr Tyr Lys 
            580                 585                 590         


Asp Leu Val Asp Met Gly Val Ala Pro Glu Leu Leu Asn Asp Glu Val 
        595                 600                 605             


Asn Ser Glu Lys Trp Glu Asp Ile Ile Lys Thr Leu Thr Ile Phe Glu 
    610                 615                 620                 


Gly Arg Lys Leu Ile Lys Arg Arg Leu Glu Asn Tyr Arg Asp Phe Leu 
625                 630                 635                 640 


Gly Glu Asp Ile Leu Arg Lys Leu Ser Arg Lys Lys Tyr Thr Gly Trp 
                645                 650                 655     


Gly Arg Leu Ser Ala Lys Leu Leu Asp Gly Ile Tyr Asp Lys Lys Thr 
            660                 665                 670         


His Lys Thr Ile Leu Asp Cys Leu Met Thr Glu Asp Tyr Ser Gln Asn 
        675                 680                 685             


Phe Met Gln Leu Ile Asn Asp Asp Asn Tyr Ser Phe Lys Glu Thr Ile 
    690                 695                 700                 


Lys Asn Ala Gln Val Ile Glu Lys Glu Glu Thr Leu Ala Lys Thr Val 
705                 710                 715                 720 


Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser 
                725                 730                 735     


Leu Glu Ile Val Asp Glu Ile Ile Lys Val Met Gly Tyr Lys Pro Lys 
            740                 745                 750         


Ser Ile Val Val Glu Met Ala Arg Glu Thr Gln Lys Thr His Gly Thr 
        755                 760                 765             


Arg Lys Arg Glu Asp Arg Val Gln Gln Ile Val Glu Asn Leu Lys Asp 
    770                 775                 780                 


Ala Asn Glu Leu Pro Glu Lys Leu Pro Ser Asn Ala Glu Leu Ser Asp 
785                 790                 795                 800 


Glu Arg Lys Tyr Leu Tyr Cys Leu Gln Asn Gly Arg Asp Met Tyr Thr 
                805                 810                 815     


Gly Ala Pro Leu Asp Tyr Asp His Leu Gln Phe Tyr Asp Val Asp His 
            820                 825                 830         


Ile Ile Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Glu Asn Lys Val 
        835                 840                 845             


Leu Thr Ile Lys Lys Glu Asn Val Arg Lys Thr Asn Gly Leu Pro Ser 
    850                 855                 860                 


Glu Ala Val Ile Gln Lys Met Gly Ser Phe Trp Lys Lys Leu Leu Asp 
865                 870                 875                 880 


Ala Gly Ala Met Thr Asn Lys Lys Tyr Asp Asn Leu Arg Arg Asn Leu 
                885                 890                 895     


His Gly Gly Leu Asn Glu Lys Leu Lys Glu Arg Phe Ile Glu Arg Gln 
            900                 905                 910         


Leu Val Glu Thr Arg Gln Ile Thr Lys Tyr Val Ala Gln Leu Leu Asp 
        915                 920                 925             


Gln Arg Leu Asn Tyr Asp Gly Asn Gly Val Glu Leu Asp Glu Lys Ile 
    930                 935                 940                 


Ala Ile Val Thr Leu Lys Ala Gln Leu Ala Ser Gln Phe Arg Ser Glu 
945                 950                 955                 960 


Phe Lys Leu Arg Lys Val Arg Ala Leu Asn Asn Leu His His Ala His 
                965                 970                 975     


Asp Ala Tyr Leu Asn Ala Ile Val Ala Asn Leu Ile Met Ala Lys Tyr 
            980                 985                 990         


Pro Glu Leu Glu Pro Glu Phe Val  Tyr Gly Lys Tyr Arg  Lys Ala Lys 
        995                 1000                 1005             


Phe Lys  Gly Leu Gly Lys Ala  Thr Ala Lys Asn Thr  Leu Tyr Ala 
    1010                 1015                 1020             


Asn Val  Leu Tyr Phe Leu Lys  Glu Asn Glu Val Tyr  Pro Phe Trp 
    1025                 1030                 1035             


Asp Lys  Ala Arg Asp Leu Pro  Thr Ile Lys Arg Tyr  Leu Tyr Arg 
    1040                 1045                 1050             


Ala Gln  Val Asn Lys Val Arg  Lys Ala Glu Arg Gln  Ile Gly Gly 
    1055                 1060                 1065             


Phe Ser  Asp Glu Met Leu Val  Pro Lys Ser Asp Ser  Gly Lys Leu 
    1070                 1075                 1080             


Leu Pro  Arg Lys Glu Gly Leu  Asp Pro Val Lys Tyr  Gly Gly Tyr 
    1085                 1090                 1095             


Ala Lys  Ala Val Glu Ser Tyr  Ala Val Leu Ile Thr  Ala Asp Glu 
    1100                 1105                 1110             


Val Lys  Lys Gly Lys Thr Lys  Lys Val Lys Thr Leu  Val Asn Ile 
    1115                 1120                 1125             


Pro Ile  Ile Asp Ser Lys Lys  Tyr Glu Ala Asp Pro  Thr Ala Tyr 
    1130                 1135                 1140             


Leu Ala  Ser Arg Gly Tyr Thr  Asn Val Thr Asn Ser  Phe Ile Leu 
    1145                 1150                 1155             


Pro Lys  Tyr Ser Leu Leu Glu  Asp Pro Glu Gly Arg  Arg Arg Tyr 
    1160                 1165                 1170             


Leu Ala  Ser Phe Lys Glu Phe  Gln Lys Ala Asn Glu  Leu Ile Leu 
    1175                 1180                 1185             


Pro Gln  His Leu Val Glu Leu  Leu Tyr Trp Val Asn  Ala Lys Asp 
    1190                 1195                 1200             


Gly Glu  Gln Lys Leu Glu Asp  His Lys Ala Glu Phe  Lys Glu Leu 
    1205                 1210                 1215             


Phe Asp  Lys Ile Met Glu Phe  Ala Asp Lys Tyr Val  Val Ala Pro 
    1220                 1225                 1230             


Lys Asn  Ser Glu Lys Ile Arg  Arg Leu Tyr Glu Glu  Asn Gln Asp 
    1235                 1240                 1245             


Ala Thr  Pro Met Glu Leu Gly  Lys Asn Phe Val Glu  Leu Leu Arg 
    1250                 1255                 1260             


Tyr Thr  Ala Asp Gly Ala Ala  Ser Asp Phe Lys Phe  Phe Gly Glu 
    1265                 1270                 1275             


Asn Ile  Pro Arg Lys Arg Tyr  Asn Ser Ala Gly Ser  Leu Leu Asn 
    1280                 1285                 1290             


Gly Thr  Leu Ile Tyr Gln Ser  Lys Thr Gly Leu Tyr  Glu Thr Arg 
    1295                 1300                 1305             


Ile Asp  Leu Gly Lys Leu 
    1310                 


<210> 265
<211> 1377
<212> PRT
<213> Lactobacillus brevis


<220>
<223> Lactobacillus brevis subsp. gravesensis ATCC 27305

<400> 265
Met Glu Ser Asn His Asp Gly Glu Gln Val Lys Tyr Thr Leu Gly Leu 
1               5                   10                  15      


Asp Ile Gly Thr Ser Ser Ile Gly Tyr Ala Ala Ile Asp Lys His Gln 
            20                  25                  30          


Lys Pro Ile Arg Ala Lys Gly Lys His Val Ile Gly Val Arg Leu Phe 
        35                  40                  45              


Gln Glu Gly Gln Thr Ala Ala Asp Arg Arg Ala Phe Arg Thr Thr Arg 
    50                  55                  60                  


Arg Arg Leu Lys Arg Arg Lys Trp Arg Leu Asn Leu Leu Asn Arg Leu 
65                  70                  75                  80  


Phe Asp Pro Tyr Leu Ser Glu Val Asp Pro Asn Phe Leu Pro Arg Leu 
                85                  90                  95      


Arg Gln Ser Asn Leu Ser Pro Lys Asp Asp Asn Lys His Phe Asn Gly 
            100                 105                 110         


Ser Thr Leu Phe Pro Asp Lys Thr Asp Ala Ala Phe Tyr Arg Gln Tyr 
        115                 120                 125             


Pro Thr Met Tyr His Leu Arg Tyr Ala Leu Met Thr Glu Lys Arg Lys 
    130                 135                 140                 


Phe Asp Ile Arg Glu Val Tyr Leu Ala Ile His His Ile Val Lys Tyr 
145                 150                 155                 160 


Arg Gly Asn Phe Leu Asn Ser Ala Thr Val Asp Ser Phe Lys Thr Ser 
                165                 170                 175     


Asn Ile Asp Phe Thr Ser Gln Phe Asp Arg Leu Asn Glu Leu Tyr Arg 
            180                 185                 190         


Gln Val Ile Leu Asp Glu Pro Phe Gln Ile Asn Met Asp Gln Val Asp 
        195                 200                 205             


Glu Met Thr Asn Lys Leu Leu Asp Asn Asp Ala Leu Lys Leu Asp Thr 
    210                 215                 220                 


Gln Lys Gln Val Ala Lys Leu Leu Pro Val Ile Tyr Asn Asp Lys Pro 
225                 230                 235                 240 


Ile Asp Lys Gln Tyr Thr Arg Ile Ala Thr Glu Phe Ser Lys Ala Ile 
                245                 250                 255     


Leu Gly Tyr Lys Thr Lys Leu Asp Val Ile Leu Asn Leu Asp Thr Gln 
            260                 265                 270         


Asn Ala Lys Asp Trp Val Ile Arg Leu Asp Asp Glu Asp Ile Asp Asp 
        275                 280                 285             


Lys Leu Pro Ala Leu Val Glu Asn Leu Asp Glu Ser Arg Gln Glu Ile 
    290                 295                 300                 


Val Thr Ile Ile Arg Asp Leu Tyr Ala Gln Ile Thr Leu Asn Ala Ile 
305                 310                 315                 320 


Val Pro Lys Gly Lys Ser Leu Ser Glu Ser Met Val Asp Lys Tyr Asn 
                325                 330                 335     


Asp His Lys Asp His Leu Asp Leu Leu Met Gly Leu Ile His Glu Leu 
            340                 345                 350         


Gly Asp Asp Ser Ala Lys Gly Ile Lys Leu Arg Glu Ala Tyr Thr Gln 
        355                 360                 365             


Tyr Val Gly Lys Ser Asp Asp Lys Thr Leu Asn Gln Asp Asp Phe Tyr 
    370                 375                 380                 


Ala Ala Ile Lys Lys Asn Leu Asp Glu Asp Ser Lys Arg Ser Pro Lys 
385                 390                 395                 400 


Ile Gln Arg Leu Ile Glu Gln Ala Ser Phe Met Pro Lys Gln Arg Thr 
                405                 410                 415     


Ser Ala Asn Gly Val Ile Pro His Gln Leu His Gln Leu Glu Leu Asp 
            420                 425                 430         


Arg Ile Ile Glu Asn Gln Gly Arg Tyr Tyr Pro Phe Leu Lys Lys Pro 
        435                 440                 445             


Asn Pro Asn Thr His Lys Pro Asn Gly Gly Lys Tyr Lys Leu Asp Glu 
    450                 455                 460                 


Leu Val Ala Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ile Thr Lys 
465                 470                 475                 480 


Arg Asp Gln Glu Lys Thr Ser Gly Ala Asp Phe Ala Trp Met Ile Arg 
                485                 490                 495     


Lys Pro Gly Gln Glu Gly Glu Ile Thr Pro Trp Asn Phe Asp Gln Lys 
            500                 505                 510         


Val Asp Arg Met Ala Ser Ala Asn Arg Phe Ile Arg Arg Met Thr Thr 
        515                 520                 525             


Lys Asp Ser Tyr Leu Val Ala Glu Asp Val Leu Pro Asp Ala Ser Leu 
    530                 535                 540                 


Ile Tyr Glu Lys Phe Lys Ala Leu Asn Glu Leu Asn Met Leu Lys Val 
545                 550                 555                 560 


Asn Asp Ser Arg Leu Ser Pro Ser Gln Lys Gln Asp Leu Phe Asn Asn 
                565                 570                 575     


Leu Phe Lys Lys Gln Lys Thr Ile Arg Thr Lys Lys Leu Gln Thr Tyr 
            580                 585                 590         


Ile Arg Thr Asn Trp Glu Leu Pro Ser Val Met Ile Ser Gly Leu Ala 
        595                 600                 605             


Asp Pro Asp Lys Phe Asn Ser Ser Leu Ser Thr Tyr Ile Asp Phe Arg 
    610                 615                 620                 


Asp Ile Phe Gly Glu Lys Val Asp Asp Pro Asn Arg Gln Ala Asp Tyr 
625                 630                 635                 640 


Glu Glu Ile Ile Glu Trp Ser Thr Val Phe Glu Asp Arg Lys Ile Tyr 
                645                 650                 655     


Gln Ala Lys Leu Asn Gln Leu Asp Trp Leu Thr Glu Pro Gln Arg Lys 
            660                 665                 670         


Ala Leu Leu Thr Lys Arg Tyr Thr Gly Trp Gly Arg Leu Ser Lys Lys 
        675                 680                 685             


Leu Leu Thr Gly Leu Lys Asp Gln Asn Gly Asp Ser Ile Leu Asp Gln 
    690                 695                 700                 


Leu Trp Lys Thr Asn Asp Asn Phe Met Gln Ile Gln Ser Arg Asp Glu 
705                 710                 715                 720 


Phe Ala Lys Gln Ile His Asp Glu Asn Ala Lys Gln Phe His Glu Ala 
                725                 730                 735     


Asn Asn Val Asp Asp Ile Leu Asp Asp Ala Phe Thr Ser Pro Gln Asn 
            740                 745                 750         


Lys Lys Ala Ile Arg Gln Val Asp Lys Val Val Gln Asp Val Val Lys 
        755                 760                 765             


Ala Val Gly Tyr Ala Pro Asp Lys Ile Ala Ile Glu Phe Thr Arg Ser 
    770                 775                 780                 


Leu Glu Asn Asn Pro Gln Arg Thr Val Ser Arg Gln Arg Gln Leu Gln 
785                 790                 795                 800 


Ala Ala Tyr Lys Asn Ile Pro Arg Glu Ile Met Lys Ser Gly Leu Met 
                805                 810                 815     


Ala Glu Leu Gly Ser Val Ala Asp Ser Lys Lys Val Leu Ser Asp Lys 
            820                 825                 830         


Leu Tyr Leu Tyr Phe Thr Gln Met Gly Lys Asp Met Tyr Glu Asp Lys 
        835                 840                 845             


Thr Ile Asn Ile Asp Asn Leu Pro Asn Tyr Asp Ile Asp His Ile Leu 
    850                 855                 860                 


Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Ile 
865                 870                 875                 880 


Ser Lys Glu Glu Asn Ala Arg Lys Ser Asn Arg Val Pro Leu Lys Phe 
                885                 890                 895     


Phe Gly Ala Lys Arg Met Gly Phe Trp Lys Asp Leu Leu Asn Asn Gly 
            900                 905                 910         


Leu Ile Ser Asn Arg Lys Phe Gln Asn Leu Thr Thr Asp Pro Glu Lys 
        915                 920                 925             


Ile Ser Lys Tyr Ser Ala Lys Gly Phe Ile His Arg Gln Leu Val Glu 
    930                 935                 940                 


Thr Ser Gln Val Ile Arg Leu Val Ala Asn Ile Leu Gly Asn Glu Tyr 
945                 950                 955                 960 


Ser Gln Ala Gly Thr Thr Ile Ile Glu Val Ser Ala Lys Met Asn Arg 
                965                 970                 975     


Gln Leu Arg Glu Asp Phe His Leu Ile Lys Asn Arg Asn Val Asn Asp 
            980                 985                 990         


Tyr His His Ala Met Asp Ala Tyr  Leu Thr Ala Tyr Val  Gly Asp Tyr 
        995                 1000                 1005             


Leu Tyr  Leu Arg Tyr Pro Lys  Leu Arg Pro Tyr Phe  Val Tyr Gly 
    1010                 1015                 1020             


Asp Phe  Lys Lys Ala Glu Asp  Gln Asp Leu Asn Ile  Arg Asn Phe 
    1025                 1030                 1035             


Asn Phe  Leu His Asp Leu Lys  Asp Asn Glu Ser Leu  Asp Lys Ile 
    1040                 1045                 1050             


Val Asp  Ser Glu Thr Gly Glu  Ile Val Trp Glu Lys  His Gly Ser 
    1055                 1060                 1065             


Val Lys  Gln Leu Lys Lys Val  Tyr His Tyr Lys Phe  Met Leu Val 
    1070                 1075                 1080             


Ser Gln  Glu Val Tyr Thr Arg  Gln Asp Ala Leu Phe  Asn Gln Thr 
    1085                 1090                 1095             


Ile Tyr  Pro Ala Ser Asp Ala  Asp Lys Arg Lys Leu  Ile Pro Ile 
    1100                 1105                 1110             


Lys Asn  Ser Lys Pro Val Asp  Val Tyr Gly Gly Tyr  Ser Gly Asn 
    1115                 1120                 1125             


Ile Asp  Ala Tyr Met Ala Ile  Val Arg Val His Gly  Lys Lys Glu 
    1130                 1135                 1140             


Asp Asn  Tyr Lys Val Val Gly  Ile Pro Met Arg Ala  Val Thr Lys 
    1145                 1150                 1155             


Leu Lys  Lys Ala Glu Lys Glu  Gly His Asp Ser Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val His  Glu Val Leu Lys Pro  Gln Phe Thr Lys Lys  Lys Lys Asn 
    1175                 1180                 1185             


Arg Lys  Thr Gly Glu Ile Thr  Glu Thr Val Asp Glu  Phe Asp Val 
    1190                 1195                 1200             


Leu Leu  Gly Lys Val Tyr Tyr  Arg Gln Leu Ile Val  Asp Gly Asn 
    1205                 1210                 1215             


Lys Lys  Phe Met Leu Gly Ser  Ser Ser Tyr Gln Tyr  Asn Ala Lys 
    1220                 1225                 1230             


Gln Leu  Val Leu Ser Asp Lys  Ala Met Gln Val Leu  Ser Lys Asn 
    1235                 1240                 1245             


Gly Lys  Val Lys Ser Gln Asp  Glu Asn Gln Asn Leu  Ile Asp Val 
    1250                 1255                 1260             


Tyr Asp  Glu Ile Leu Glu Lys  Val Asp Gln Tyr Phe  Glu Leu Tyr 
    1265                 1270                 1275             


Asp Gln  Arg His Tyr Arg Glu  Ser Leu His Lys Gly  Arg Gly Ile 
    1280                 1285                 1290             


Phe Val  Asn Leu Pro Leu Ser  Asn Gln Tyr Asp Gly  Ser Lys Leu 
    1295                 1300                 1305             


Thr Ser  Tyr Gly Lys Tyr Glu  Thr Ile Asp Ala Ile  Leu Asn Gly 
    1310                 1315                 1320             


Leu His  Ala Asn Ala Thr Met  Ser Asn Leu Arg Tyr  Leu Gly Ile 
    1325                 1330                 1335             


Ser Ser  Pro Phe Gly Lys Met  Gln Ala Ser Asn Gly  Leu Thr Ile 
    1340                 1345                 1350             


Asp Pro  Asp Ser Ile Ile Cys  Tyr Gln Ser Pro Thr  Gly Leu Phe 
    1355                 1360                 1365             


Glu Arg  Gln Ile Lys Leu Ser  Asp Leu 
    1370                 1375         


<210> 266
<211> 1371
<212> PRT
<213> Lactobacillus buchneri

<400> 266
Met Lys Val Asn Asn Tyr His Ile Gly Leu Asp Ile Gly Thr Ser Ser 
1               5                   10                  15      


Ile Gly Trp Val Ala Ile Gly Lys Asp Gly Lys Pro Leu Arg Val Lys 
            20                  25                  30          


Gly Lys Thr Ala Ile Gly Ala Arg Leu Phe Gln Glu Gly Asn Pro Ala 
        35                  40                  45              


Ala Asp Arg Arg Met Phe Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg 
    50                  55                  60                  


Lys Trp Arg Leu Lys Leu Leu Glu Glu Ile Phe Asp Pro Tyr Ile Thr 
65                  70                  75                  80  


Pro Val Asp Ser Thr Phe Phe Ala Arg Leu Lys Gln Ser Asn Leu Ser 
                85                  90                  95      


Pro Lys Asp Ser Arg Lys Glu Phe Lys Gly Ser Met Leu Phe Pro Asp 
            100                 105                 110         


Leu Thr Asp Met Gln Tyr His Lys Asn Tyr Pro Thr Ile Tyr His Leu 
        115                 120                 125             


Arg His Ala Leu Met Thr Gln Asp Lys Lys Phe Asp Ile Arg Met Val 
    130                 135                 140                 


Tyr Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Asn 
145                 150                 155                 160 


Ser Thr Pro Val Asp Ser Phe Lys Ala Ser Lys Val Asp Phe Val Asp 
                165                 170                 175     


Gln Phe Lys Lys Leu Asn Glu Leu Tyr Ala Ala Ile Asn Pro Glu Glu 
            180                 185                 190         


Ser Phe Lys Ile Asn Leu Ala Asn Ser Glu Asp Ile Gly His Gln Phe 
        195                 200                 205             


Leu Asp Pro Ser Ile Arg Lys Phe Asp Lys Lys Lys Gln Ile Pro Lys 
    210                 215                 220                 


Ile Val Pro Val Met Met Asn Asp Lys Val Thr Asp Arg Leu Asn Gly 
225                 230                 235                 240 


Lys Ile Ala Ser Glu Ile Ile His Ala Ile Leu Gly Tyr Lys Ala Lys 
                245                 250                 255     


Leu Asp Val Val Leu Gln Cys Thr Pro Val Asp Ser Lys Pro Trp Ala 
            260                 265                 270         


Leu Lys Phe Asp Asp Glu Asp Ile Asp Ala Lys Leu Glu Lys Ile Leu 
        275                 280                 285             


Pro Glu Met Asp Glu Asn Gln Gln Ser Ile Val Ala Ile Leu Gln Asn 
    290                 295                 300                 


Leu Tyr Ser Gln Val Thr Leu Asn Gln Ile Val Pro Asn Gly Met Ser 
305                 310                 315                 320 


Leu Ser Glu Ser Met Ile Glu Lys Tyr Asn Asp His His Asp His Leu 
                325                 330                 335     


Lys Leu Tyr Lys Lys Leu Ile Asp Gln Leu Ala Asp Pro Lys Lys Lys 
            340                 345                 350         


Ala Val Leu Lys Lys Ala Tyr Ser Gln Tyr Val Gly Asp Asp Gly Lys 
        355                 360                 365             


Val Ile Glu Gln Ala Glu Phe Trp Ser Ser Val Lys Lys Asn Leu Asp 
    370                 375                 380                 


Asp Ser Glu Leu Ser Lys Gln Ile Met Asp Leu Ile Asp Ala Glu Lys 
385                 390                 395                 400 


Phe Met Pro Lys Gln Arg Thr Ser Gln Asn Gly Val Ile Pro His Gln 
                405                 410                 415     


Leu His Gln Arg Glu Leu Asp Glu Ile Ile Glu His Gln Ser Lys Tyr 
            420                 425                 430         


Tyr Pro Trp Leu Val Glu Ile Asn Pro Asn Lys His Asp Leu His Leu 
        435                 440                 445             


Ala Lys Tyr Lys Ile Glu Gln Leu Val Ala Phe Arg Val Pro Tyr Tyr 
    450                 455                 460                 


Val Gly Pro Met Ile Thr Pro Lys Asp Gln Ala Glu Ser Ala Glu Thr 
465                 470                 475                 480 


Val Phe Ser Trp Met Glu Arg Lys Gly Thr Glu Thr Gly Gln Ile Thr 
                485                 490                 495     


Pro Trp Asn Phe Asp Glu Lys Val Asp Arg Lys Ala Ser Ala Asn Arg 
            500                 505                 510         


Phe Ile Lys Arg Met Thr Thr Lys Asp Thr Tyr Leu Ile Gly Glu Asp 
        515                 520                 525             


Val Leu Pro Asp Glu Ser Leu Leu Tyr Glu Lys Phe Lys Val Leu Asn 
    530                 535                 540                 


Glu Leu Asn Met Val Arg Val Asn Gly Lys Leu Leu Lys Val Ala Asp 
545                 550                 555                 560 


Lys Gln Ala Ile Phe Gln Asp Leu Phe Glu Asn Tyr Lys His Val Ser 
                565                 570                 575     


Val Lys Lys Leu Gln Asn Tyr Ile Lys Ala Lys Thr Gly Leu Pro Ser 
            580                 585                 590         


Asp Pro Glu Ile Ser Gly Leu Ser Asp Pro Glu His Phe Asn Asn Ser 
        595                 600                 605             


Leu Gly Thr Tyr Asn Asp Phe Lys Lys Leu Phe Gly Ser Lys Val Asp 
    610                 615                 620                 


Glu Pro Asp Leu Gln Asp Asp Phe Glu Lys Ile Val Glu Trp Ser Thr 
625                 630                 635                 640 


Val Phe Glu Asp Lys Lys Ile Leu Arg Glu Lys Leu Asn Glu Ile Thr 
                645                 650                 655     


Trp Leu Ser Asp Gln Gln Lys Asp Val Leu Glu Ser Ser Arg Tyr Gln 
            660                 665                 670         


Gly Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Gly Ile Val Asn Asp 
        675                 680                 685             


Gln Gly Glu Arg Ile Ile Asp Lys Leu Trp Asn Thr Asn Lys Asn Phe 
    690                 695                 700                 


Met Gln Ile Gln Ser Asp Asp Asp Phe Ala Lys Arg Ile His Glu Ala 
705                 710                 715                 720 


Asn Ala Asp Gln Met Gln Ala Val Asp Val Glu Asp Val Leu Ala Asp 
                725                 730                 735     


Ala Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile Arg Gln Val Val Lys 
            740                 745                 750         


Val Val Asp Asp Ile Gln Lys Ala Met Gly Gly Val Ala Pro Lys Tyr 
        755                 760                 765             


Ile Ser Ile Glu Phe Thr Arg Ser Glu Asp Arg Asn Pro Arg Arg Thr 
    770                 775                 780                 


Ile Ser Arg Gln Arg Gln Leu Glu Asn Thr Leu Lys Asp Thr Ala Lys 
785                 790                 795                 800 


Ser Leu Ala Lys Ser Ile Asn Pro Glu Leu Leu Ser Glu Leu Asp Asn 
                805                 810                 815     


Ala Ala Lys Ser Lys Lys Gly Leu Thr Asp Arg Leu Tyr Leu Tyr Phe 
            820                 825                 830         


Thr Gln Leu Gly Lys Asp Ile Tyr Thr Gly Glu Pro Ile Asn Ile Asp 
        835                 840                 845             


Glu Leu Asn Lys Tyr Asp Ile Asp His Ile Leu Pro Gln Ala Phe Ile 
    850                 855                 860                 


Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val Leu Thr Ala Val Asn 
865                 870                 875                 880 


Asn Gly Lys Ser Asp Asn Val Pro Leu Arg Met Phe Gly Ala Lys Met 
                885                 890                 895     


Gly His Phe Trp Lys Gln Leu Ala Glu Ala Gly Leu Ile Ser Lys Arg 
            900                 905                 910         


Lys Leu Lys Asn Leu Gln Thr Asp Pro Asp Thr Ile Ser Lys Tyr Ala 
        915                 920                 925             


Met His Gly Phe Ile Arg Arg Gln Leu Val Glu Thr Ser Gln Val Ile 
    930                 935                 940                 


Lys Leu Val Ala Asn Ile Leu Gly Asp Lys Tyr Arg Asn Asp Asp Thr 
945                 950                 955                 960 


Lys Ile Ile Glu Ile Thr Ala Arg Met Asn His Gln Met Arg Asp Glu 
                965                 970                 975     


Phe Gly Phe Ile Lys Asn Arg Glu Ile Asn Asp Tyr His His Ala Phe 
            980                 985                 990         


Asp Ala Tyr Leu Thr Ala Phe Leu  Gly Arg Tyr Leu Tyr  His Arg Tyr 
        995                 1000                 1005             


Ile Lys  Leu Arg Pro Tyr Phe  Val Tyr Gly Asp Phe  Lys Lys Phe 
    1010                 1015                 1020             


Arg Glu  Asp Lys Val Thr Met  Arg Asn Phe Asn Phe  Leu His Asp 
    1025                 1030                 1035             


Leu Thr  Asp Asp Thr Gln Glu  Lys Ile Ala Asp Ala  Glu Thr Gly 
    1040                 1045                 1050             


Glu Val  Ile Trp Asp Arg Glu  Asn Ser Ile Gln Gln  Leu Lys Asp 
    1055                 1060                 1065             


Val Tyr  His Tyr Lys Phe Met  Leu Ile Ser His Glu  Val Tyr Thr 
    1070                 1075                 1080             


Leu Arg  Gly Ala Met Phe Asn  Gln Thr Val Tyr Pro  Ala Ser Asp 
    1085                 1090                 1095             


Ala Gly  Lys Arg Lys Leu Ile  Pro Val Lys Ala Asp  Arg Pro Val 
    1100                 1105                 1110             


Asn Val  Tyr Gly Gly Tyr Ser  Gly Ser Ala Asp Ala  Tyr Met Ala 
    1115                 1120                 1125             


Ile Val  Arg Ile His Asn Lys  Lys Gly Asp Lys Tyr  Arg Val Val 
    1130                 1135                 1140             


Gly Val  Pro Met Arg Ala Leu  Asp Arg Leu Asp Ala  Ala Lys Asn 
    1145                 1150                 1155             


Val Ser  Asp Ala Asp Phe Asp  Arg Ala Leu Lys Asp  Val Leu Ala 
    1160                 1165                 1170             


Pro Gln  Leu Thr Lys Thr Lys  Lys Ser Arg Lys Thr  Gly Glu Ile 
    1175                 1180                 1185             


Thr Gln  Val Ile Glu Asp Phe  Glu Ile Val Leu Gly  Lys Val Met 
    1190                 1195                 1200             


Tyr Arg  Gln Leu Met Ile Asp  Gly Asp Lys Lys Phe  Met Leu Gly 
    1205                 1210                 1215             


Ser Ser  Thr Tyr Gln Tyr Asn  Ala Lys Gln Leu Val  Leu Ser Asp 
    1220                 1225                 1230             


Gln Ser  Val Lys Thr Leu Ala  Ser Lys Gly Arg Leu  Asp Pro Leu 
    1235                 1240                 1245             


Gln Glu  Ser Met Asp Tyr Asn  Asn Val Tyr Thr Glu  Ile Leu Asp 
    1250                 1255                 1260             


Lys Val  Asn Gln Tyr Phe Ser  Leu Tyr Asp Met Asn  Lys Phe Arg 
    1265                 1270                 1275             


His Lys  Leu Asn Leu Gly Phe  Ser Lys Phe Ile Ser  Phe Pro Asn 
    1280                 1285                 1290             


His Asn  Val Leu Asp Gly Asn  Thr Lys Val Ser Ser  Gly Lys Arg 
    1295                 1300                 1305             


Glu Ile  Leu Gln Glu Ile Leu  Asn Gly Leu His Ala  Asn Pro Thr 
    1310                 1315                 1320             


Phe Gly  Asn Leu Lys Asp Val  Gly Ile Thr Thr Pro  Phe Gly Gln 
    1325                 1330                 1335             


Leu Gln  Gln Pro Asn Gly Ile  Leu Leu Ser Asp Glu  Thr Lys Ile 
    1340                 1345                 1350             


Arg Tyr  Gln Ser Pro Thr Gly  Leu Phe Glu Arg Thr  Val Ser Leu 
    1355                 1360                 1365             


Lys Asp  Leu 
    1370     


<210> 267
<211> 1371
<212> PRT
<213> Lactobacillus buchneri

<400> 267
Met Lys Val Asn Asn Tyr His Ile Gly Leu Asp Ile Gly Thr Ser Ser 
1               5                   10                  15      


Ile Gly Trp Val Ala Ile Gly Glu Asp Gly Lys Pro Leu Arg Ile Lys 
            20                  25                  30          


Gly Lys Thr Ala Ile Gly Ala Arg Leu Phe Gln Glu Gly Asn Pro Ala 
        35                  40                  45              


Ala Asp Arg Arg Met Phe Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg 
    50                  55                  60                  


Lys Trp Arg Leu Lys Leu Leu Glu Glu Ile Phe Asp Pro Tyr Ile Thr 
65                  70                  75                  80  


Pro Val Asp Ser Thr Phe Phe Ala Arg Leu Lys Gln Ser Asn Leu Ser 
                85                  90                  95      


Pro Lys Asp Ser Arg Lys Glu Phe Lys Gly Ser Met Leu Phe Pro Asp 
            100                 105                 110         


Leu Thr Asp Met Gln Tyr His Lys Asp Tyr Pro Thr Ile Tyr His Leu 
        115                 120                 125             


Arg His Ala Leu Met Thr Gln Asp Glu Lys Phe Asp Ile Arg Met Val 
    130                 135                 140                 


Tyr Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Asn 
145                 150                 155                 160 


Ser Thr Pro Val Asp Ser Phe Lys Ala Ser Lys Val Asn Phe Val Asp 
                165                 170                 175     


Gln Phe Lys Lys Leu Asn Glu Leu Tyr Thr Ala Ile Asn Pro Glu Glu 
            180                 185                 190         


Ser Phe Gln Ile Asn Leu Ala Asn Ser Glu Asp Ile Gly His Gln Phe 
        195                 200                 205             


Leu Asp Pro Ser Ile Arg Lys Phe Asp Lys Lys Lys Gln Ile Pro Lys 
    210                 215                 220                 


Ile Val Pro Val Ser Val Asp Asp Lys Ala Thr Asp Lys Ile Asn Gly 
225                 230                 235                 240 


Lys Ile Ala Ser Glu Ile Ile Asn Ala Ile Leu Gly Tyr Lys Ser Lys 
                245                 250                 255     


Leu Asp Val Val Val Gln Cys Thr Pro Val Asp Ser Lys Ser Trp Ala 
            260                 265                 270         


Leu Lys Phe Asp Glu Glu Asp Ile Asp Ala Lys Leu Gln Lys Ile Leu 
        275                 280                 285             


Pro Glu Met Asp Glu Asn Gln Gln Ser Ile Ile Ala Ile Leu Gln Asn 
    290                 295                 300                 


Leu Tyr Ser Gln Val Thr Leu Asn Gln Ile Val Pro Asn Gly Met Ser 
305                 310                 315                 320 


Leu Ser Glu Ser Met Ile Glu Lys Tyr Asn Asp His His Asp His Leu 
                325                 330                 335     


Lys Leu Tyr Lys Lys Ile Ile Asp Gln Leu Ala Asp Pro Lys Lys Lys 
            340                 345                 350         


Ala Ala Leu Lys Lys Ala Tyr Ser Gln Tyr Val Gly Asp Asp Gly Lys 
        355                 360                 365             


Val Ile Glu Gln Ala Asp Phe Trp Ser Ser Val Lys Lys Asn Leu Asp 
    370                 375                 380                 


Asp Ser Asp Leu Ser Lys Gln Ile Met Asp Leu Ile Asp Ala Glu Lys 
385                 390                 395                 400 


Phe Met Pro Lys Gln Arg Thr Ser Gln Asn Gly Val Ile Pro His Gln 
                405                 410                 415     


Leu His Gln Arg Glu Leu Asp Glu Ile Ile Glu His Gln Ser Lys Tyr 
            420                 425                 430         


Tyr Pro Trp Leu Ala Glu Ile Asn Pro Asn Lys His Asp Leu His Leu 
        435                 440                 445             


Ala Lys Tyr Lys Ile Glu Glu Leu Val Ala Phe Arg Val Pro Tyr Tyr 
    450                 455                 460                 


Val Gly Pro Met Ile Thr Pro Asp Asp Gln Ala Lys Ser Ala Glu Thr 
465                 470                 475                 480 


Val Phe Ser Trp Met Glu Arg Lys Gly Lys Glu Ala Gly Gln Ile Thr 
                485                 490                 495     


Pro Trp Asn Phe Asp Glu Lys Val Asp Arg Asn Ala Ser Ala Asn Arg 
            500                 505                 510         


Phe Ile Lys Arg Met Thr Thr Lys Asp Thr Tyr Leu Ile Gly Glu Asp 
        515                 520                 525             


Val Leu Pro Asp Glu Ser Leu Leu Tyr Glu Lys Phe Lys Val Leu Asn 
    530                 535                 540                 


Glu Leu Asn Met Val Arg Val Asn Gly Lys Leu Leu Lys Val Ala Asp 
545                 550                 555                 560 


Lys Gln Ala Ile Phe Gln Asp Leu Phe Glu Asn Tyr Lys His Ile Ser 
                565                 570                 575     


Val Lys Lys Leu Gln Asn Tyr Ile Lys Ser Lys Thr Gly Leu Pro Ser 
            580                 585                 590         


Asp Pro Glu Ile Ser Gly Leu Ser Asp Pro Glu Tyr Phe Asn Asn Ser 
        595                 600                 605             


Leu Gly Thr Tyr Asn Asp Phe Lys Lys Leu Phe Gly Asn Lys Val Asp 
    610                 615                 620                 


Glu Pro Asp Leu Gln Asp Asp Phe Glu Lys Ile Val Glu Trp Ser Thr 
625                 630                 635                 640 


Val Phe Glu Asp Lys Arg Ile Leu Arg Glu Lys Leu Asn Glu Ile Thr 
                645                 650                 655     


Trp Leu Ser Asp Gln Gln Lys Asp Val Leu Glu Ser Ser Arg Tyr Gln 
            660                 665                 670         


Gly Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Gly Ile Val Asn Asp 
        675                 680                 685             


Gln Gly Glu Arg Ile Ile Asp Glu Leu Trp Asn Thr Asn Lys Asn Phe 
    690                 695                 700                 


Met Gln Ile Gln Ser Asp Asn Asp Phe Ala Lys Arg Ile His Glu Ala 
705                 710                 715                 720 


Asn Ala Asp Gln Met Lys Ala Val Asp Val Glu Asp Val Leu Ala Asp 
                725                 730                 735     


Ala Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile Arg Gln Val Val Lys 
            740                 745                 750         


Val Val Asp Asp Ile Gln Lys Ala Met Gly Gly Val Ala Pro Lys Tyr 
        755                 760                 765             


Ile Ser Ile Glu Phe Thr Arg Ser Glu Asp Arg Asn Pro Arg Arg Thr 
    770                 775                 780                 


Ile Ser Arg Gln Arg Gln Leu Glu Asn Thr Leu Lys Asp Thr Ala Lys 
785                 790                 795                 800 


Ser Leu Ala Lys Ser Ile Asn Pro Glu Leu Leu Ser Glu Leu Asp Asn 
                805                 810                 815     


Ala Ala Lys Ser Lys Lys Gly Leu Thr Asp Arg Leu Tyr Leu Tyr Phe 
            820                 825                 830         


Thr Gln Leu Gly Lys Asp Ile Tyr Thr Gly Lys Pro Ile Asn Ile Asp 
        835                 840                 845             


Glu Ile Ser Thr Tyr Asp Ile Asp His Ile Leu Pro Gln Ala Phe Val 
    850                 855                 860                 


Lys Asp Asp Ser Leu Asn Asn Arg Val Leu Val Ser Lys Ala Ile Asn 
865                 870                 875                 880 


Asn Gly Lys Ser Asp Asn Val Pro Val Gln Leu Phe Gly Ala Lys Met 
                885                 890                 895     


Gly His Phe Trp Lys Gln Leu Ala Glu Ala Gly Leu Ile Ser Lys Arg 
            900                 905                 910         


Lys Leu Lys Asn Leu Gln Thr Asp Pro Asp Thr Ile Ser Lys Tyr Ala 
        915                 920                 925             


Met His Gly Phe Ile Arg Arg Gln Leu Val Glu Thr Ser Gln Val Ile 
    930                 935                 940                 


Lys Leu Val Ala Asn Ile Leu Gly Asp Lys Tyr Arg Asn Asp Asn Thr 
945                 950                 955                 960 


Lys Ile Ile Glu Ile Thr Ala Arg Met Asn His Gln Met Arg Asp Glu 
                965                 970                 975     


Phe Gly Phe Ile Lys Asn Arg Glu Ile Asn Asp Tyr His His Ala Phe 
            980                 985                 990         


Asp Ala Tyr Leu Thr Ala Phe Leu  Gly Arg Tyr Leu Tyr  His Arg Tyr 
        995                 1000                 1005             


Ile Lys  Leu Arg Pro Tyr Phe  Val Tyr Gly Asp Phe  Lys Lys Phe 
    1010                 1015                 1020             


Lys Glu  Asp Lys Val Thr Met  Arg Asn Phe Asn Phe  Leu His Asp 
    1025                 1030                 1035             


Leu Thr  Asp Asp Thr Gln Glu  Lys Ile Ala Asp Ala  Glu Thr Gly 
    1040                 1045                 1050             


Glu Val  Ile Trp Asp Arg Glu  Asn Ser Ile Gln Gln  Leu Lys Asp 
    1055                 1060                 1065             


Val Tyr  His Tyr Lys Phe Met  Leu Ile Ser His Glu  Val Tyr Thr 
    1070                 1075                 1080             


Leu Arg  Gly Ala Met Phe Asn  Gln Thr Val Tyr Pro  Ala Ser Asp 
    1085                 1090                 1095             


Ala Gly  Lys Arg Lys Leu Ile  Pro Ile Lys Ala Asp  Arg Pro Ile 
    1100                 1105                 1110             


Asn Val  Tyr Gly Gly Tyr Ser  Gly Ser Ala Asp Ala  Tyr Met Ala 
    1115                 1120                 1125             


Ile Val  Arg Ile His Asn Lys  Lys Gly Asp Lys Tyr  Arg Val Val 
    1130                 1135                 1140             


Gly Val  Pro Met Arg Ala Arg  Asp Arg Leu Asp Ala  Ala Lys Lys 
    1145                 1150                 1155             


Val Ser  Asp Ala Asp Cys Asp  Arg Ala Leu Lys Asp  Val Leu Thr 
    1160                 1165                 1170             


Pro Gln  Leu Thr Lys Thr Lys  Lys Ser Arg Lys Thr  Gly Glu Ile 
    1175                 1180                 1185             


Thr Gln  Val Val Glu Asp Phe  Glu Ile Val Leu Gly  Lys Val Met 
    1190                 1195                 1200             


Tyr Arg  Gln Leu Met Ile Asp  Gly Asp Lys Lys Phe  Met Leu Gly 
    1205                 1210                 1215             


Ser Ser  Thr Tyr Gln Tyr Asn  Ala Lys Gln Leu Val  Leu Ser Asp 
    1220                 1225                 1230             


Gln Ser  Val Lys Thr Leu Ala  Ser Lys Gly Arg Leu  Asp Pro Leu 
    1235                 1240                 1245             


Gln Glu  Ser Met Asp Tyr Asn  Asn Val Tyr Thr Glu  Ile Leu Asp 
    1250                 1255                 1260             


Lys Val  Asn Gln Tyr Phe Ser  Leu Tyr Asp Met Asn  Lys Phe Arg 
    1265                 1270                 1275             


His Lys  Leu Asn Leu Gly Phe  Ser Lys Phe Ile Ser  Phe Pro Asn 
    1280                 1285                 1290             


His Asn  Val Phe Asp Gly Asn  Thr Lys Ala Ser Ser  Gly Lys Arg 
    1295                 1300                 1305             


Glu Ile  Leu Glu Glu Val Leu  Asn Gly Leu His Ala  Asn Pro Thr 
    1310                 1315                 1320             


Phe Gly  Asn Leu Lys Asp Ile  Gly Ile Thr Thr Pro  Phe Gly Gln 
    1325                 1330                 1335             


Leu Gln  Gln Pro Asn Gly Ile  Leu Leu Ser Asp Glu  Ala Lys Ile 
    1340                 1345                 1350             


Arg Tyr  Gln Ser Pro Thr Gly  Leu Phe Glu Arg Thr  Val Ser Leu 
    1355                 1360                 1365             


Lys Asp  Leu 
    1370     


<210> 268
<211> 1361
<212> PRT
<213> Lactobacillus casei


<220>
<223> Lactobacillus casei BL23

<400> 268
Met Thr Lys Leu Gly Lys Pro Tyr Gly Ile Gly Val Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg 
            20                  25                  30          


Leu Lys Gly Lys Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys 
        35                  40                  45              


Ala Ala Ala Asp Arg Arg Ala Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Asn Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Glu Ser His 
65                  70                  75                  80  


Ile Thr Pro Thr Gly Pro Asn Phe Phe Met Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Ala Arg Tyr Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Gln Gln Tyr Pro Thr Met Tyr 
        115                 120                 125             


His Leu Arg Asn Arg Leu Leu Thr Asp Pro Ser Lys Ala Asp Val Arg 
    130                 135                 140                 


Glu Ile Tyr Phe Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Ser Gly Tyr Ala Lys Asp Phe Asn Thr Asn Lys Val Ala Leu 
                165                 170                 175     


Asn Glu Ile Phe Pro Ala Leu Gln Asp Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Asp Ile Thr Phe Asp Glu Asn Lys Val Asn Glu Phe Lys Thr 
        195                 200                 205             


Val Leu Leu Asn Glu Lys Ala Thr Pro Ser Asp Thr Gln Arg Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ala Glu Asp Gly Asp Lys Asp Ile Leu Lys Gln 
225                 230                 235                 240 


Gln Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 
                245                 250                 255     


Thr Lys Leu Asn Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 
            260                 265                 270         


Thr Val Trp Asn Phe Ser Leu Gly Gln Leu Asp Asp Lys Trp Ala Gly 
        275                 280                 285             


Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gln Ile 
    290                 295                 300                 


Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Lys Thr Leu Ser Gln Ala Lys Val Asp Asp Tyr Ala Gln His His Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Asp Tyr Leu Lys Gln Leu Glu Asp Asp Gly 
            340                 345                 350         


Thr Ala Lys Ala Ile Arg Gln Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg 
385                 390                 395                 400 


Leu Ala Gln Pro Asp Phe Met Leu Lys Gln Arg Asn Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Val Gln Met Gln Gln Arg Glu Leu Asp Gln Ile Ile Lys 
            420                 425                 430         


Asn Gln Ser Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 
        435                 440                 445             


Lys His Arg Lys Ser Met Pro Tyr Gln Leu Asp Glu Leu Leu Asn Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gln Lys 
465                 470                 475                 480 


Ala Ala Gln Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 
            500                 505                 510         


Ser Ala Asn Thr Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Arg Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asn Glu Lys Leu 
545                 550                 555                 560 


Ser Ile Glu Gln Lys Gln Gln Val Ile Arg Glu Leu Phe Glu Arg His 
                565                 570                 575     


Asn Ser Val Thr Ile Lys Gln Phe Ala Glu Asn Leu Arg Ala His Gly 
            580                 585                 590         


Asp Tyr Ala His Ile Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr Arg Gln Leu Lys Ser Leu Leu Pro 
    610                 615                 620                 


Asp Ala Ile Asp Asp Pro Ala Lys Gln Ala Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Ala Trp Ser Thr Val Phe Glu Asp Ala Ala Ile Phe Lys Thr Lys Leu 
                645                 650                 655     


Lys Glu Ile Asn Trp Leu Asp Ser Gln Thr Ile Thr Lys Leu Ser Asn 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser His Lys Phe Leu Asn Gly 
        675                 680                 685             


Leu Thr Leu Gly Asn Gly His Thr Ile Ile Gln Glu Leu Phe Leu Ser 
    690                 695                 700                 


Asn Asn Asn Leu Met Gln Ile Leu Thr Asp Glu Thr Leu Gln Lys Lys 
705                 710                 715                 720 


Met Thr Glu Leu Asn Ala Asp Lys Leu Lys Ala Ala Asn Ile Asn Asp 
                725                 730                 735     


Ala Ile Asp Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Arg Val Ile Glu Asp Ile Lys Arg Ala Ala Asp Gly Gln 
        755                 760                 765             


Asp Pro Ser Trp Leu Tyr Val Glu Thr Ala Asp Gly Gly Gly Thr Pro 
    770                 775                 780                 


Gly Lys Arg Thr Arg Ala Arg Gln His Gln Leu Gln Glu Ile Tyr Ala 
785                 790                 795                 800 


Asn Ala Ala His Glu Leu Ile Asp Ser Ala Val Arg Gly Glu Leu Glu 
                805                 810                 815     


Asp Lys Ile Ala Asp Lys Ala Asp Phe Asn Asp Arg Leu Val Leu Tyr 
            820                 825                 830         


Phe Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Thr Pro Leu Asn Ile 
        835                 840                 845             


Asp Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu 
    850                 855                 860                 


Ile Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val His Ala Ile Ile 
865                 870                 875                 880 


Asn Arg Glu Lys Asn Ala Thr Phe Ala Ser Thr Ile Tyr Ala Gln Lys 
                885                 890                 895     


Met Asn Ala Thr Trp Arg Gln Trp His Glu Ala Gly Leu Ile Ser Gly 
            900                 905                 910         


Arg Lys Leu Arg Asn Leu Gln Met Arg Pro Asp Gln Ile Asp Lys Tyr 
        915                 920                 925             


Ala Ser Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile 
    930                 935                 940                 


Lys Leu Thr Glu Gln Ile Val Ala Ala Gln Tyr Pro Glu Thr Lys Ile 
945                 950                 955                 960 


Ile Ala Val Lys Ala Gly Leu Ser His Gln Leu Arg Glu Glu Leu Glu 
                965                 970                 975     


Phe Pro Lys Asn Arg Asp Val Asn His Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Phe Leu Ala Ala Arg Ile Gly Thr  Tyr Leu Leu Lys Arg  Phe Pro Asn 
        995                 1000                 1005             


Leu Gln  Ala Phe Phe Thr Tyr  Gly Lys Phe Lys Lys  Ala Asp Val 
    1010                 1015                 1020             


Lys Lys  Leu Arg Gly Phe Asn  Phe Ile Arg Asp Ile  Thr His Ala 
    1025                 1030                 1035             


Glu Asp  Lys Ile Val Val Lys  Asp Thr Gly Glu Val  Ile Trp Asp 
    1040                 1045                 1050             


Lys Lys  Arg Asp Val Asp Glu  Leu Asp Arg Ile Tyr  Asn Phe Lys 
    1055                 1060                 1065             


Arg Met  Leu Ile Thr His Glu  Val His Phe Glu Lys  Ala Asp Leu 
    1070                 1075                 1080             


Phe Lys  Gln Thr Val Tyr Gly  Ala Lys Asp Ser Lys  Glu Ala Gly 
    1085                 1090                 1095             


Gly Lys  Lys Gln Leu Ile Ser  Lys Lys Lys Gly Tyr  Pro Val Asp 
    1100                 1105                 1110             


Ile Tyr  Gly Gly Tyr Thr Gln  Glu Thr Gly Ser Tyr  Leu Ser Val 
    1115                 1120                 1125             


Val Arg  Leu Thr Lys Lys Ala  Met Tyr Ala Val Val  Lys Val Ser 
    1130                 1135                 1140             


Thr Arg  Asp Ala Ala Lys Leu  Ala Val Ala Lys Ser  Ile Ser Glu 
    1145                 1150                 1155             


Gln Lys  Glu Asn Glu Thr Leu  Asn Asp Ile Ile Asp  Glu Lys Leu 
    1160                 1165                 1170             


Ser Lys  Ile Ser Lys Asn Gly  Lys Ile Thr His Glu  Leu Phe Glu 
    1175                 1180                 1185             


Val Val  Leu Pro Arg Val Gly  Gln Lys Thr Leu Phe  Lys Asn Ser 
    1190                 1195                 1200             


Lys Tyr  Asn Leu Phe Leu Val  Asn Ser Asp Thr Tyr  Met His Asn 
    1205                 1210                 1215             


Tyr Gln  Glu Leu Trp Met Pro  Arg Glu Tyr Gln Lys  Met Trp Lys 
    1220                 1225                 1230             


Asp Ile  Ser Leu Ser Lys Tyr  Gly Asp Ala Gln Thr  Glu Asp Gln 
    1235                 1240                 1245             


Leu Asp  Gln Ile Phe Gly Phe  Ile Val Ser Gln Val  Asn Ser Tyr 
    1250                 1255                 1260             


Phe Asn  Leu Tyr Asp Ile Asn  Gln Phe Arg Lys Lys  Leu Asn Asp 
    1265                 1270                 1275             


Ala Ala  Asp Lys Phe Ala Thr  Leu Pro Met Arg Asp  Thr Asp Asp 
    1280                 1285                 1290             


Met Gln  Gly Lys Ile Ala Thr  Ile Gly Gln Leu Leu  Ile Gly Leu 
    1295                 1300                 1305             


Gln Ala  Asn Ala Ala Arg Ser  Asp Leu Arg Asn Leu  Asp Ile Lys 
    1310                 1315                 1320             


Thr Pro  Leu Gly Leu Leu Gln  Ile Pro Asn Gly Ile  Ser Leu Asp 
    1325                 1330                 1335             


Ser Asp  Thr Ser Val Val Tyr  Gln Ser Pro Thr Gly  Leu Leu Glu 
    1340                 1345                 1350             


Arg Glu  Val His Leu Ser Asp  Leu 
    1355                 1360     


<210> 269
<211> 1361
<212> PRT
<213> Lactobacillus casei


<220>
<223> Lactobacillus casei Lc-10

<400> 269
Met Thr Lys Leu Gly Lys Pro Tyr Gly Ile Gly Val Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg 
            20                  25                  30          


Leu Lys Gly Lys Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys 
        35                  40                  45              


Ala Ala Ala Asp Arg Arg Ala Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Asn Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Glu Ser His 
65                  70                  75                  80  


Ile Thr Pro Thr Gly Pro Asn Phe Phe Met Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Ala Arg Tyr Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Gln Gln Tyr Pro Thr Met Tyr 
        115                 120                 125             


His Leu Arg Asn Arg Leu Leu Thr Asp Pro Ser Lys Ala Asp Val Arg 
    130                 135                 140                 


Glu Ile Tyr Phe Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Ser Gly Tyr Ala Lys Asp Phe Asn Thr Asn Lys Val Ala Leu 
                165                 170                 175     


Asn Glu Ile Phe Pro Ala Leu Gln Asp Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Asp Ile Thr Phe Asp Glu Asn Lys Val Asn Glu Phe Lys Thr 
        195                 200                 205             


Val Leu Leu Asn Glu Lys Ala Thr Pro Ser Asp Thr Gln Arg Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ala Glu Asp Gly Asp Lys Asp Ile Leu Lys Gln 
225                 230                 235                 240 


Gln Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 
                245                 250                 255     


Thr Lys Leu Asn Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 
            260                 265                 270         


Thr Val Trp Asn Phe Ser Leu Gly Gln Leu Asp Asp Lys Trp Ala Gly 
        275                 280                 285             


Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gln Ile 
    290                 295                 300                 


Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Asn Thr Leu Ser Gln Ala Lys Val Asp Asp Tyr Ala Gln His His Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Asp Tyr Leu Lys Gln Leu Glu Asp Asp Gly 
            340                 345                 350         


Thr Ala Lys Ala Ile Arg Gln Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg 
385                 390                 395                 400 


Leu Ala Gln Pro Asp Phe Met Leu Lys Gln Arg Asn Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Val Gln Met Gln Gln Arg Glu Leu Asp Gln Ile Ile Lys 
            420                 425                 430         


Asn Gln Ser Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 
        435                 440                 445             


Lys His Arg Lys Ser Met Pro Tyr Gln Leu Asp Glu Leu Leu Asn Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gln Lys 
465                 470                 475                 480 


Ala Ala Gln Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 
            500                 505                 510         


Ser Ala Asn Thr Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Arg Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asn Glu Lys Leu 
545                 550                 555                 560 


Ser Ile Glu Gln Lys Gln Gln Val Ile Arg Glu Leu Phe Glu Arg His 
                565                 570                 575     


Asn Ser Val Thr Ile Lys Gln Phe Ala Glu Asn Leu Arg Ala His Gly 
            580                 585                 590         


Asp Tyr Ala His Ile Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr Arg Gln Leu Lys Ser Leu Leu Pro 
    610                 615                 620                 


Asp Ala Ile Asp Asp Pro Ala Lys Gln Ala Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Ala Trp Ser Thr Val Phe Glu Asp Ala Ala Ile Phe Lys Thr Lys Leu 
                645                 650                 655     


Lys Glu Ile Asn Trp Leu Asp Ser Gln Thr Ile Thr Lys Leu Ser Asn 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser His Lys Phe Leu Asn Gly 
        675                 680                 685             


Leu Thr Leu Gly Asn Gly His Thr Ile Ile Gln Glu Leu Phe Leu Ser 
    690                 695                 700                 


Asn Asn Asn Leu Met Gln Ile Leu Thr Asp Glu Thr Leu Gln Lys Lys 
705                 710                 715                 720 


Met Thr Glu Leu Asn Ala Asp Lys Leu Lys Ala Ala Asn Ile Asn Asp 
                725                 730                 735     


Ala Ile Asp Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Arg Val Ile Glu Asp Ile Lys Arg Ala Ala Asp Gly Gln 
        755                 760                 765             


Asp Pro Ser Trp Leu Tyr Val Glu Thr Ala Asp Gly Gly Gly Thr Pro 
    770                 775                 780                 


Gly Lys Arg Thr Arg Ala Arg Gln His Gln Leu Gln Glu Ile Tyr Ala 
785                 790                 795                 800 


Asn Ala Ala His Glu Leu Ile Asp Ser Ala Val Arg Gly Glu Leu Glu 
                805                 810                 815     


Asp Lys Ile Ala Asp Lys Ala Asp Phe Asn Asp Arg Leu Val Leu Tyr 
            820                 825                 830         


Phe Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Thr Pro Leu Asn Ile 
        835                 840                 845             


Asp Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu 
    850                 855                 860                 


Ile Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val His Ala Ile Ile 
865                 870                 875                 880 


Asn Arg Glu Lys Asn Ala Thr Phe Ala Ser Thr Ile Tyr Ala Gln Lys 
                885                 890                 895     


Met Asn Ala Thr Trp Arg Gln Trp His Glu Ala Gly Leu Ile Ser Gly 
            900                 905                 910         


Arg Lys Leu Arg Asn Leu Gln Met Arg Pro Asp Gln Ile Asp Lys Tyr 
        915                 920                 925             


Ala Ser Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile 
    930                 935                 940                 


Lys Leu Thr Glu Gln Ile Val Ala Ala Gln Tyr Pro Glu Thr Lys Ile 
945                 950                 955                 960 


Ile Ala Val Lys Ala Gly Leu Ser His Gln Leu Arg Glu Glu Leu Glu 
                965                 970                 975     


Phe Pro Lys Asn Arg Asp Val Asn His Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Phe Leu Ala Ala Arg Ile Gly Thr  Tyr Leu Leu Lys Arg  Phe Pro Asn 
        995                 1000                 1005             


Leu Gln  Ala Phe Phe Thr Tyr  Gly Lys Phe Lys Lys  Ala Asp Val 
    1010                 1015                 1020             


Lys Lys  Leu Arg Gly Phe Asn  Phe Ile Arg Asp Ile  Thr His Ala 
    1025                 1030                 1035             


Glu Asp  Lys Ile Val Val Lys  Asp Thr Gly Glu Val  Ile Trp Asp 
    1040                 1045                 1050             


Lys Lys  Arg Asp Val Asp Glu  Leu Asp Arg Ile Tyr  Asn Phe Lys 
    1055                 1060                 1065             


Arg Met  Leu Ile Thr His Glu  Val His Phe Glu Lys  Ala Asp Leu 
    1070                 1075                 1080             


Phe Lys  Gln Thr Val Tyr Gly  Ala Lys Asp Ser Lys  Glu Ala Gly 
    1085                 1090                 1095             


Gly Lys  Lys Gln Leu Ile Ser  Lys Lys Lys Gly Tyr  Pro Val Asp 
    1100                 1105                 1110             


Ile Tyr  Gly Gly Tyr Thr Gln  Glu Thr Gly Ser Tyr  Leu Ser Val 
    1115                 1120                 1125             


Val Arg  Leu Thr Lys Lys Ala  Met Tyr Ala Val Val  Lys Val Ser 
    1130                 1135                 1140             


Thr Arg  Asp Ala Ala Lys Leu  Ala Val Ala Lys Ser  Ile Ser Glu 
    1145                 1150                 1155             


Gln Lys  Glu Asn Glu Thr Leu  Asn Asp Ile Ile Asp  Glu Lys Leu 
    1160                 1165                 1170             


Ser Lys  Ile Ser Lys Asn Gly  Lys Ile Thr His Glu  Leu Phe Glu 
    1175                 1180                 1185             


Val Val  Leu Pro Arg Val Gly  Gln Lys Thr Leu Phe  Lys Asn Ser 
    1190                 1195                 1200             


Lys Tyr  Asn Leu Phe Leu Val  Asn Ser Asp Thr Tyr  Met His Asn 
    1205                 1210                 1215             


Tyr Gln  Glu Leu Trp Met Pro  Arg Glu Tyr Gln Lys  Met Trp Lys 
    1220                 1225                 1230             


Asp Ile  Ser Leu Ser Lys Tyr  Gly Asp Ala Gln Thr  Glu Asp Gln 
    1235                 1240                 1245             


Leu Asp  Gln Ile Phe Gly Phe  Ile Val Ser Gln Val  Asn Ser Tyr 
    1250                 1255                 1260             


Phe Asn  Leu Tyr Asp Ile Asn  Gln Phe Arg Lys Lys  Leu Asn Asp 
    1265                 1270                 1275             


Ala Ala  Asp Lys Phe Ala Thr  Leu Pro Met Arg Asp  Thr Asp Asp 
    1280                 1285                 1290             


Met Gln  Gly Lys Ile Ala Thr  Ile Gly Gln Leu Leu  Ile Gly Leu 
    1295                 1300                 1305             


Gln Ala  Asn Ala Ala Arg Ser  Asp Leu Arg Asn Leu  Asp Ile Lys 
    1310                 1315                 1320             


Thr Pro  Leu Gly Leu Leu Gln  Ile Pro Asn Gly Ile  Ser Leu Asp 
    1325                 1330                 1335             


Ser Asp  Thr Ser Val Val Tyr  Gln Ser Pro Thr Gly  Leu Leu Glu 
    1340                 1345                 1350             


Arg Glu  Val His Leu Ser Asp  Leu 
    1355                 1360     


<210> 270
<211> 1363
<212> PRT
<213> Lactobacillus casei


<220>
<223> Lactobacillus casei M36

<400> 270
Met Thr Lys Leu Gly Lys Pro Tyr Gly Ile Gly Val Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg 
            20                  25                  30          


Leu Lys Gly Lys Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys 
        35                  40                  45              


Ala Ala Ala Asp Arg Arg Ala Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Asn Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Glu Ser His 
65                  70                  75                  80  


Ile Thr Pro Thr Asp Pro Asn Phe Phe Met Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Ala Arg Tyr Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Gln Gln Tyr Pro Thr Met Tyr 
        115                 120                 125             


His Leu Arg Asn Arg Leu Leu Thr Asp Pro Ser Lys Ala Asp Val Arg 
    130                 135                 140                 


Glu Ile Tyr Phe Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Ser Gly Tyr Ala Lys Asp Phe Asn Thr Asn Lys Val Ala Leu 
                165                 170                 175     


Asn Glu Ile Phe Pro Ala Leu Gln Asp Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Asp Ile Thr Phe Asp Glu Asn Lys Val Asn Glu Phe Lys Thr 
        195                 200                 205             


Val Leu Leu Asp Glu Lys Ala Thr Pro Ser Asp Thr Gln Arg Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ala Glu Asp Gly Asp Lys Asp Ile Leu Lys Gln 
225                 230                 235                 240 


Gln Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 
                245                 250                 255     


Met Lys Leu Asn Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 
            260                 265                 270         


Thr Ala Trp Asn Phe Ser Leu Gly Gln Leu Asp Asp Lys Trp Ala Gly 
        275                 280                 285             


Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gln Ile 
    290                 295                 300                 


Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Lys Thr Leu Ser Gln Ala Lys Val Asp Asp Tyr Glu Gln His His Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Asp Tyr Leu Lys Gln Leu Glu Asp Asp Gly 
            340                 345                 350         


Met Ala Lys Val Ile Arg Gln Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg 
385                 390                 395                 400 


Leu Val Gln Pro Asp Phe Met Leu Lys Gln Arg Asn Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Val Gln Met Gln Gln Arg Glu Leu Asp Gln Ile Ile Lys 
            420                 425                 430         


Asn Gln Ser Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 
        435                 440                 445             


Lys His Arg Gln Ser Met Pro Tyr Gln Leu Asp Glu Leu Leu Asn Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gln Lys 
465                 470                 475                 480 


Ala Ala Gln Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 
            500                 505                 510         


Ser Ala Asn Thr Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Ser Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asp Asn Lys Leu 
545                 550                 555                 560 


Ser Phe Asp Gln Lys Gln Gln Val Leu Gly Glu Leu Phe Glu Arg His 
                565                 570                 575     


Asn Thr Val Thr Ile Lys Gln Phe Val Asp Asn Leu Leu Ala His Gly 
            580                 585                 590         


Asp Tyr Asp Arg Ile Pro Glu Val Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr Asn Gln Leu Lys Gly Ile Leu His 
    610                 615                 620                 


Glu Ala Ile Asp Asp Ser Asp Lys Gln Thr Asp Ile Glu Lys Ile Ile 
625                 630                 635                 640 


Ala Trp Ser Thr Ile Phe Glu Asp Lys Ala Ile Phe Lys Thr Lys Leu 
                645                 650                 655     


Asn Glu Ile Ser Trp Leu Thr Ala Gly Met Ile Asn Ser Leu Ala Asn 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser His Lys Leu Leu Asn Glu 
        675                 680                 685             


Leu Thr Leu Ser Thr Gly Arg Thr Val Phe Glu Glu Leu Leu Ile Ser 
    690                 695                 700                 


Ser His Asn Leu Met Gln Ile Leu Thr Asp Glu Val Leu Lys Gln Lys 
705                 710                 715                 720 


Ile Ala Glu Leu Asn Ala His Glu Leu Lys Ala Ser Gly Ile Tyr Ala 
                725                 730                 735     


Ala Ile Asp Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Ser Val Ile Asp Asp Ile Thr Asn Ala Ala Gly Gln Ala 
        755                 760                 765             


Pro Asn Trp Leu Tyr Ile Glu Thr Ala Asp Gly Asp Gly Val Pro Gly 
    770                 775                 780                 


Lys Arg Thr Asn Ser Arg Gln Arg Lys Ile Gln Glu Ile Tyr Ala Asn 
785                 790                 795                 800 


Ala Ala Gln Glu Leu Ile Thr Gly Ser Val Arg Gly Glu Leu Glu Asp 
                805                 810                 815     


Lys Ile Ala Ser Arg Ala Asp Phe Thr Asp Arg Leu Val Leu Tyr Phe 
            820                 825                 830         


Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Glu Pro Leu Asn Ile Asp 
        835                 840                 845             


Asn Leu Ser Ser Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu Ile 
    850                 855                 860                 


Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val His Pro Leu Val Asn 
865                 870                 875                 880 


Arg Glu Lys Asp Thr Ile Phe Ala Ser Thr Arg Phe Ala Lys Gln Met 
                885                 890                 895     


Asn Gly Met Trp Arg Gln Trp His Ala Ala Gly Leu Ile Ser Ser Arg 
            900                 905                 910         


Lys Leu Arg Asn Leu Gln Met Arg Pro Asp Glu Ile Asp Lys Tyr Ala 
        915                 920                 925             


Ser Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Lys 
    930                 935                 940                 


Leu Thr Glu Gln Ile Val Ala Asp Gln Tyr Pro Asp Ala Lys Ile Ile 
945                 950                 955                 960 


Ala Val Lys Ala Gly Leu Ser Ser Gln Leu Arg Lys Glu Leu Asp Phe 
                965                 970                 975     


Pro Lys Asn Arg Glu Val Asn His Tyr His His Ala Phe Asp Ala Phe 
            980                 985                 990         


Leu Ala Ala Arg Ile Gly Thr Tyr  Leu Leu Lys Arg Tyr  Pro Asn Leu 
        995                 1000                 1005             


Glu Pro  Phe Phe Thr Tyr Gly  Lys Phe Lys Lys Thr  Glu Val Lys 
    1010                 1015                 1020             


Lys Leu  Lys Ser Leu Lys Ser  Phe Asn Phe Ile Arg  Asp Met Thr 
    1025                 1030                 1035             


His Ala  Lys Asp Lys Ile Val  Ala Lys Glu Thr Gly  Glu Ile Val 
    1040                 1045                 1050             


Trp Asp  Asn Ala Ser Asp Ile  Asn Glu Leu Asp Arg  Ile Tyr Asn 
    1055                 1060                 1065             


Phe Lys  Arg Met Leu Ile Thr  His Glu Val Arg Phe  Glu Thr Ala 
    1070                 1075                 1080             


Ser Leu  Phe Lys Gln Thr Leu  Tyr Ala Ala Lys Asn  Ser Lys Asn 
    1085                 1090                 1095             


Arg Gly  Gly Ser Arg Gln Leu  Ile Pro Lys Lys Lys  Gly Tyr Leu 
    1100                 1105                 1110             


Val Asp  Ile Tyr Gly Gly Tyr  Thr Gln Glu Thr Gly  Ser Tyr Leu 
    1115                 1120                 1125             


Ser Val  Val Arg Leu Thr Lys  Lys Ala Met Tyr Ala  Val Val Lys 
    1130                 1135                 1140             


Val Ser  Thr Arg Asp Ala Ala  Lys Leu Ala Val Ala  Lys Ser Ile 
    1145                 1150                 1155             


Ser Glu  Gln Lys Glu Asn Glu  Thr Leu Lys Lys Ile  Ile Asp Gly 
    1160                 1165                 1170             


Lys Leu  Ser Lys Thr Ser Lys  Lys Gly Lys Thr Thr  His Gln Leu 
    1175                 1180                 1185             


Phe Glu  Ile Val Leu Pro Arg  Val Gly Gln Lys Thr  Leu Phe Lys 
    1190                 1195                 1200             


Asn Ser  Lys Tyr Asn Gln Phe  Leu Val Asn Ser Asp  Thr Tyr Met 
    1205                 1210                 1215             


His Asn  Tyr Gln Glu Leu Trp  Met Pro Arg Glu Tyr  Gln Arg Met 
    1220                 1225                 1230             


Trp Lys  Asp Ile Leu Leu Ser  Asn His Gly Asp Ala  Gln Leu Glu 
    1235                 1240                 1245             


Gly Gln  Leu Asp Gln Ile Phe  Lys Phe Ile Val Ser  Gln Val Asn 
    1250                 1255                 1260             


Ser Tyr  Phe Asn Leu Tyr Asp  Ile Asn Gln Phe Arg  Lys Lys Ile 
    1265                 1270                 1275             


Ala Asp  Ala Thr Asp Lys Phe  Ala Lys Leu Pro Thr  His Asp Thr 
    1280                 1285                 1290             


Asp Asn  Ala Arg Gly Lys Ile  Ala Thr Ile Gly Gln  Leu Leu Ile 
    1295                 1300                 1305             


Gly Leu  Gln Ala Asn Ala Met  Arg Ser Asp Leu Arg  Asn Leu Asp 
    1310                 1315                 1320             


Ile Lys  Thr Pro Phe Gly Leu  Leu Gln Ile Gly Thr  Gly Ile Thr 
    1325                 1330                 1335             


Leu Asp  Leu Asp Thr Ser Ile  Ile Tyr Gln Ser Pro  Thr Gly Leu 
    1340                 1345                 1350             


Phe Glu  Arg Glu Val Pro Leu  Thr Asp Leu 
    1355                 1360             


<210> 271
<211> 1361
<212> PRT
<213> Lactobacillus casei


<220>
<223> Lactobacillus casei group

<400> 271
Met Thr Lys Leu Gly Lys Pro Tyr Gly Ile Gly Val Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg 
            20                  25                  30          


Leu Lys Gly Lys Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys 
        35                  40                  45              


Ala Ala Ala Asp Arg Arg Ala Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Asn Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Glu Ser His 
65                  70                  75                  80  


Ile Thr Pro Thr Gly Pro Asn Phe Phe Met Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Ala Arg Tyr Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Gln Gln Tyr Pro Thr Met Tyr 
        115                 120                 125             


His Leu Arg Asn Arg Leu Leu Thr Asp Pro Ser Lys Ala Asp Val Arg 
    130                 135                 140                 


Glu Ile Tyr Phe Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Ser Gly Tyr Ala Lys Asp Phe Asn Thr Asn Lys Val Ala Leu 
                165                 170                 175     


Asn Glu Ile Phe Pro Ala Leu Gln Asp Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Asp Ile Thr Phe Asp Glu Asn Lys Val Asn Glu Phe Lys Thr 
        195                 200                 205             


Val Leu Leu Asn Glu Lys Ala Thr Pro Ser Asp Thr Gln Arg Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ala Glu Asp Gly Asp Lys Asp Ile Leu Lys Gln 
225                 230                 235                 240 


Gln Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 
                245                 250                 255     


Thr Lys Leu Asn Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 
            260                 265                 270         


Thr Val Trp Asn Phe Ser Leu Gly Gln Leu Asp Asp Lys Trp Ala Gly 
        275                 280                 285             


Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gln Ile 
    290                 295                 300                 


Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Lys Thr Leu Ser Gln Ala Lys Val Asp Asp Tyr Ala Gln His His Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Asp Tyr Leu Lys Gln Leu Glu Asp Asp Gly 
            340                 345                 350         


Thr Ala Lys Ala Ile Arg Gln Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg 
385                 390                 395                 400 


Leu Ala Gln Pro Asp Phe Met Leu Lys Gln Arg Asn Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Val Gln Met Gln Gln Arg Glu Leu Asp Gln Ile Ile Lys 
            420                 425                 430         


Asn Gln Ser Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 
        435                 440                 445             


Lys His Arg Lys Ser Met Pro Tyr Gln Leu Asp Glu Leu Leu Asn Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gln Lys 
465                 470                 475                 480 


Ala Ala Gln Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 
            500                 505                 510         


Ser Ala Asn Thr Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Arg Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asn Glu Lys Leu 
545                 550                 555                 560 


Ser Ile Glu Gln Lys Gln Gln Val Ile Arg Glu Leu Phe Glu Arg His 
                565                 570                 575     


Asn Ser Val Thr Ile Lys Gln Phe Ala Glu Asn Leu Arg Ala His Gly 
            580                 585                 590         


Asp Tyr Ala His Ile Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr Arg Gln Leu Lys Ser Leu Leu Pro 
    610                 615                 620                 


Asp Ala Ile Asp Asp Pro Ala Lys Gln Ala Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Ala Trp Ser Thr Val Phe Glu Asp Ala Ala Ile Phe Lys Thr Lys Leu 
                645                 650                 655     


Lys Glu Ile Asn Trp Leu Asp Ser Gln Thr Ile Thr Lys Leu Ser Asn 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser His Lys Phe Leu Asn Gly 
        675                 680                 685             


Leu Thr Leu Gly Asn Gly His Thr Ile Ile Gln Glu Leu Phe Leu Ser 
    690                 695                 700                 


Asn Asn Asn Leu Met Gln Ile Leu Thr Asp Glu Thr Leu Gln Lys Lys 
705                 710                 715                 720 


Met Thr Glu Leu Asn Ala Asp Lys Leu Lys Ala Ala Asn Ile Asn Asp 
                725                 730                 735     


Ala Ile Asp Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Arg Val Ile Glu Asp Ile Lys Arg Ala Ala Asp Gly Gln 
        755                 760                 765             


Asp Pro Ser Trp Leu Tyr Val Glu Thr Ala Asp Gly Gly Gly Thr Pro 
    770                 775                 780                 


Gly Lys Arg Thr Arg Ala Arg Gln His Gln Leu Gln Glu Ile Tyr Ala 
785                 790                 795                 800 


Asn Ala Ala His Glu Leu Ile Asp Ser Ala Val Arg Gly Glu Leu Glu 
                805                 810                 815     


Asp Lys Ile Ala Asp Lys Ala Asp Phe Asn Asp Arg Leu Val Leu Tyr 
            820                 825                 830         


Phe Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Thr Pro Leu Asn Ile 
        835                 840                 845             


Asp Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu 
    850                 855                 860                 


Ile Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val His Ala Ile Ile 
865                 870                 875                 880 


Asn Arg Glu Lys Asn Ala Thr Phe Ala Ser Thr Ile Tyr Ala Gln Lys 
                885                 890                 895     


Met Asn Ala Thr Trp Arg Gln Trp His Glu Ala Gly Leu Ile Ser Gly 
            900                 905                 910         


Arg Lys Leu Arg Asn Leu Gln Met Arg Pro Asp Gln Ile Asp Lys Tyr 
        915                 920                 925             


Ala Ser Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile 
    930                 935                 940                 


Lys Leu Thr Glu Gln Ile Val Ala Ala Gln Tyr Pro Glu Thr Lys Ile 
945                 950                 955                 960 


Ile Ala Val Lys Ala Gly Leu Ser His Gln Leu Arg Glu Glu Leu Glu 
                965                 970                 975     


Phe Pro Lys Asn Arg Asp Val Asn His Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Phe Leu Ala Ala Arg Ile Gly Thr  Tyr Leu Leu Lys Arg  Phe Pro Asn 
        995                 1000                 1005             


Leu Gln  Ala Phe Phe Thr Tyr  Gly Lys Phe Lys Lys  Ala Asp Val 
    1010                 1015                 1020             


Lys Lys  Leu Arg Gly Phe Asn  Phe Ile Arg Asp Ile  Thr His Ala 
    1025                 1030                 1035             


Glu Asp  Lys Ile Val Val Lys  Asp Thr Gly Glu Val  Ile Trp Asp 
    1040                 1045                 1050             


Lys Lys  Arg Asp Val Asp Glu  Leu Asp Arg Ile Tyr  Asn Phe Lys 
    1055                 1060                 1065             


Arg Met  Leu Ile Thr His Glu  Val His Phe Glu Lys  Ala Asp Leu 
    1070                 1075                 1080             


Phe Lys  Gln Thr Val Tyr Gly  Ala Lys Asp Ser Lys  Glu Ala Gly 
    1085                 1090                 1095             


Gly Lys  Lys Gln Leu Ile Ser  Lys Lys Lys Gly Tyr  Pro Val Asp 
    1100                 1105                 1110             


Ile Tyr  Gly Gly Tyr Thr Gln  Glu Thr Gly Ser Tyr  Leu Ser Val 
    1115                 1120                 1125             


Val Arg  Leu Thr Lys Lys Ala  Met Tyr Ala Val Val  Lys Val Ser 
    1130                 1135                 1140             


Thr Arg  Asp Ala Ala Lys Leu  Ala Val Ala Lys Ser  Ile Ser Glu 
    1145                 1150                 1155             


Gln Lys  Glu Asn Glu Thr Leu  Asn Asp Ile Ile Asp  Glu Lys Leu 
    1160                 1165                 1170             


Ser Lys  Ile Ser Lys Asn Gly  Lys Ile Thr His Glu  Leu Phe Glu 
    1175                 1180                 1185             


Val Val  Leu Pro Arg Val Gly  Gln Lys Thr Leu Phe  Lys Asn Ser 
    1190                 1195                 1200             


Lys Tyr  Asn Leu Phe Leu Val  Asn Ser Asp Thr Tyr  Met His Asn 
    1205                 1210                 1215             


Tyr Gln  Glu Leu Trp Met Pro  Arg Glu Tyr Gln Lys  Met Trp Lys 
    1220                 1225                 1230             


Asp Ile  Ser Leu Ser Lys Tyr  Gly Asp Ala Gln Thr  Glu Asp Gln 
    1235                 1240                 1245             


Leu Asp  Gln Ile Phe Gly Phe  Ile Val Ser Gln Val  Asn Ser Tyr 
    1250                 1255                 1260             


Phe Asn  Leu Tyr Asp Ile Asn  Gln Phe Arg Lys Lys  Leu Asn Asp 
    1265                 1270                 1275             


Ala Ala  Asp Lys Phe Ala Thr  Leu Pro Met Arg Asp  Thr Asp Asp 
    1280                 1285                 1290             


Met Gln  Gly Lys Ile Ala Thr  Ile Gly Gln Leu Leu  Ile Gly Leu 
    1295                 1300                 1305             


Gln Ala  Asn Ala Ala Arg Ser  Asp Leu Arg Asn Leu  Asp Ile Lys 
    1310                 1315                 1320             


Thr Pro  Leu Gly Leu Leu Gln  Ile Pro Asn Gly Ile  Ser Leu Asp 
    1325                 1330                 1335             


Ser Asp  Thr Ser Val Val Tyr  Gln Ser Pro Thr Gly  Leu Leu Glu 
    1340                 1345                 1350             


Arg Glu  Val His Leu Ser Asp  Leu 
    1355                 1360     


<210> 272
<211> 1360
<212> PRT
<213> Lactobacillus casei


<220>
<223> Lactobacillus casei T71499

<400> 272
Met Thr Lys Leu Gly Lys Pro Tyr Gly Ile Gly Val Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg 
            20                  25                  30          


Leu Lys Gly Lys Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys 
        35                  40                  45              


Ala Ala Ala Asp Arg Arg Ala Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Asn Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Glu Ser His 
65                  70                  75                  80  


Ile Thr Pro Thr Asp Pro Asn Phe Phe Met Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Ala Arg Tyr Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Gln Gln Tyr Pro Thr Met Tyr 
        115                 120                 125             


His Leu Arg Thr Arg Leu Leu Thr Asp Pro Ser Lys Ala Asp Val Arg 
    130                 135                 140                 


Glu Ile Tyr Phe Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Pro Gly Tyr Ala Lys Asp Phe Asn Thr Asn Lys Val Ala Leu 
                165                 170                 175     


Asn Glu Ile Phe Pro Ala Leu Gln Asp Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Asp Ile Thr Phe Asp Glu Asn Lys Val Asn Glu Phe Lys Thr 
        195                 200                 205             


Val Leu Leu Asn Glu Lys Ala Thr Pro Ser Asp Thr Gln Arg Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ala Glu Asp Gly Asp Lys Asp Ile Leu Lys Gln 
225                 230                 235                 240 


Gln Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 
                245                 250                 255     


Thr Lys Leu Asn Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 
            260                 265                 270         


Thr Val Trp Asn Phe Ser Leu Gly Gln Leu Asp Asp Lys Trp Ala Gly 
        275                 280                 285             


Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gln Ile 
    290                 295                 300                 


Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Lys Thr Leu Ser Gln Ala Lys Val Asp Asp Tyr Ala Gln His His Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Asp Tyr Leu Lys Gln Leu Glu Asp Asp Gly 
            340                 345                 350         


Thr Ala Lys Ala Ile Arg Gln Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg 
385                 390                 395                 400 


Leu Ala Gln Pro Asp Phe Met Leu Lys Gln Arg Asn Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Val Gln Met Gln Gln Arg Glu Leu Asp Gln Ile Ile Lys 
            420                 425                 430         


Asn Gln Ser Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 
        435                 440                 445             


Lys His Arg Lys Ser Met Pro Tyr Gln Leu Asp Glu Leu Leu Asn Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gln Lys 
465                 470                 475                 480 


Ala Ala Gln Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 
            500                 505                 510         


Ser Ala Asn Thr Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Ser Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asp Asn Lys Leu 
545                 550                 555                 560 


Ser Phe Asp Gln Lys Gln Gln Val Leu Gly Glu Leu Phe Glu Arg His 
                565                 570                 575     


Asn Thr Val Thr Ile Lys Gln Phe Val Asp Asn Leu Leu Ala His Gly 
            580                 585                 590         


Asp Tyr Asp Arg Ile Pro Glu Val Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr Asn Gln Leu Lys Gly Ile Leu His 
    610                 615                 620                 


Glu Ala Ile Asp Asp Ala Asp Lys Gln Thr Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Ala Trp Ser Thr Ile Phe Glu Asp Lys Ala Ile Phe Lys Thr Lys Leu 
                645                 650                 655     


Asn Glu Ile Ser Trp Leu Asn Ala Gly Met Ile Asn Ser Leu Ala Asn 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser His Lys Leu Leu Asn Glu 
        675                 680                 685             


Leu Thr Leu Ser Thr Gly Arg Thr Val Phe Glu Glu Leu Leu Ile Ser 
    690                 695                 700                 


Ser Arg Asn Leu Met Gln Ile Leu Thr Asp Glu Val Leu Lys Gln Lys 
705                 710                 715                 720 


Ile Ala Glu Leu Asn Ala His Glu Leu Lys Ala Ser Gly Ile Tyr Ala 
                725                 730                 735     


Ala Ile Asp Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Ser Val Ile Asp Asp Ile Thr Asn Ala Ala Gly Gln Ala 
        755                 760                 765             


Pro Asn Trp Leu Tyr Ile Glu Thr Ala Asp Gly Asp Gly Val Pro Gly 
    770                 775                 780                 


Lys Arg Thr Asn Ser Arg Gln Arg Lys Ile Gln Glu Ile Tyr Ala Asn 
785                 790                 795                 800 


Ala Ala Gln Glu Leu Ile Thr Gly Ser Val Arg Gly Glu Leu Glu Asp 
                805                 810                 815     


Lys Ile Ala Ser Arg Ala Asp Phe Thr Asp Arg Leu Val Leu Tyr Phe 
            820                 825                 830         


Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Glu Pro Leu Asn Ile Asp 
        835                 840                 845             


Asn Leu Ser Ser Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu Ile 
    850                 855                 860                 


Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val His Pro Leu Val Asn 
865                 870                 875                 880 


Arg Glu Lys Asp Thr Ile Phe Ala Ser Thr Arg Phe Ala Lys Gln Met 
                885                 890                 895     


Asn Gly Met Trp Arg Gln Trp His Ala Ala Gly Leu Ile Ser Ser Arg 
            900                 905                 910         


Lys Leu Arg Asn Leu Gln Met Arg Pro Asp Glu Ile Asp Lys Tyr Ala 
        915                 920                 925             


Ser Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Lys 
    930                 935                 940                 


Leu Thr Glu Gln Ile Val Ala Asp Gln Tyr Pro Asp Thr Lys Ile Ile 
945                 950                 955                 960 


Ala Val Lys Ala Gly Leu Ser Ser Gln Leu Arg Lys Glu Leu Asp Phe 
                965                 970                 975     


Pro Lys Asn Arg Glu Val Asn His Tyr His His Ala Phe Asp Ala Phe 
            980                 985                 990         


Leu Ala Ala Arg Ile Gly Thr Tyr  Leu Leu Lys Arg Tyr  Pro Asn Leu 
        995                 1000                 1005             


Glu Pro  Phe Phe Thr Tyr Gly  Lys Phe Lys Lys Thr  Glu Val Lys 
    1010                 1015                 1020             


Lys Leu  Lys Ser Phe Asn Phe  Ile Arg Asp Met Thr  His Ala Lys 
    1025                 1030                 1035             


Asp Lys  Ile Val Ala Lys Glu  Thr Gly Glu Ile Val  Trp Asp Asn 
    1040                 1045                 1050             


Ala Ser  Asp Ile Asn Glu Leu  Asp Arg Ile Tyr Asn  Phe Lys Arg 
    1055                 1060                 1065             


Met Leu  Ile Thr His Glu Val  Arg Phe Glu Thr Ala  Ser Leu Phe 
    1070                 1075                 1080             


Lys Gln  Thr Leu Tyr Ala Ala  Lys Asn Ser Lys Asn  Arg Gly Gly 
    1085                 1090                 1095             


Ser Arg  Gln Leu Ile Pro Lys  Lys Lys Gly Tyr Leu  Val Asp Ile 
    1100                 1105                 1110             


Tyr Gly  Gly Tyr Thr Gln Glu  Thr Gly Ser Tyr Leu  Ser Val Val 
    1115                 1120                 1125             


Arg Leu  Thr Lys Lys Ala Met  Tyr Ala Val Val Lys  Val Ser Thr 
    1130                 1135                 1140             


Arg Asp  Ala Ala Lys Leu Ala  Val Ala Lys Ser Ile  Ser Glu Gln 
    1145                 1150                 1155             


Lys Glu  Asn Glu Thr Leu Lys  Lys Ile Ile Asp Gly  Lys Leu Ser 
    1160                 1165                 1170             


Lys Thr  Ser Lys Lys Gly Lys  Thr Thr His Gln Leu  Phe Glu Ile 
    1175                 1180                 1185             


Val Leu  Pro Arg Val Gly Gln  Lys Thr Leu Phe Lys  Asn Ser Lys 
    1190                 1195                 1200             


Tyr Asn  Gln Phe Leu Val Asn  Ser Asp Thr Tyr Met  His Asn Tyr 
    1205                 1210                 1215             


Gln Glu  Leu Trp Met Pro Arg  Glu Tyr Gln Arg Met  Trp Lys Asp 
    1220                 1225                 1230             


Ile Leu  Leu Ser Asn His Gly  Asp Ala Gln Leu Glu  Gly Gln Leu 
    1235                 1240                 1245             


Asp Gln  Ile Phe Lys Phe Ile  Val Ser Gln Val Asn  Ser Tyr Phe 
    1250                 1255                 1260             


Asn Leu  Tyr Asp Ile Asn Gln  Phe Arg Lys Lys Ile  Ala Asp Ala 
    1265                 1270                 1275             


Thr Asp  Lys Phe Ala Lys Leu  Pro Thr His Asp Thr  Asp Asn Ala 
    1280                 1285                 1290             


Arg Gly  Lys Ile Ala Thr Ile  Gly Gln Leu Leu Ile  Gly Leu Gln 
    1295                 1300                 1305             


Ala Asn  Ala Met Arg Ser Asp  Leu Arg Asn Leu Asp  Ile Lys Thr 
    1310                 1315                 1320             


Pro Phe  Gly Leu Leu Gln Ile  Gly Thr Gly Ile Thr  Leu Asp Leu 
    1325                 1330                 1335             


Asp Thr  Ser Ile Ile Tyr Gln  Ser Pro Thr Gly Leu  Phe Glu Arg 
    1340                 1345                 1350             


Glu Val  Pro Leu Thr Asp Leu  
    1355                 1360 


<210> 273
<211> 1366
<212> PRT
<213> Lactobacillus casei


<220>
<223> Lactobacillus casei UCD174

<400> 273
Met Thr Lys Leu Gly Lys Pro Tyr Gly Ile Gly Val Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg 
            20                  25                  30          


Leu Lys Gly Lys Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys 
        35                  40                  45              


Ala Ala Ala Tyr Arg Arg Ala Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Asn Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Glu Ser His 
65                  70                  75                  80  


Ile Thr Pro Thr Asp Pro Asn Phe Phe Met Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Ala Arg Tyr Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Gln Gln Tyr Pro Thr Met Tyr 
        115                 120                 125             


His Leu Arg Thr Arg Leu Leu Thr Asp Pro Ser Lys Ala Asp Val Arg 
    130                 135                 140                 


Glu Ile Tyr Phe Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Pro Gly Tyr Ala Lys Asp Phe Asn Thr Asn Lys Val Ala Leu 
                165                 170                 175     


Asn Glu Ile Phe Pro Ala Leu Gln Asp Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Asp Ile Thr Phe Asp Glu Asn Lys Val Asn Glu Phe Lys Thr 
        195                 200                 205             


Val Leu Leu Asn Glu Lys Ala Thr Pro Ser Asp Thr Gln Arg Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ala Lys Glu Gly Asp Arg Asp Ile Leu Lys Gln 
225                 230                 235                 240 


Gln Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 
                245                 250                 255     


Thr Lys Leu Asn Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 
            260                 265                 270         


Thr Ala Trp Asn Phe Ser Leu Gly Gln Leu Asp Asp Lys Trp Ala Gly 
        275                 280                 285             


Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gln Ile 
    290                 295                 300                 


Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Lys Thr Leu Ser Gln Ala Lys Val Asp Asp Tyr Ala Gln His His Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Asp Tyr Leu Lys Gln Leu Glu Asp Asp Gly 
            340                 345                 350         


Thr Ala Lys Ala Ile Arg Gln Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg 
385                 390                 395                 400 


Leu Ala Gln Pro Asp Phe Met Leu Lys Gln Arg Asn Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Val Gln Met Gln Gln Arg Glu Leu Asp Gln Ile Ile Lys 
            420                 425                 430         


Asn Gln Ala Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 
        435                 440                 445             


Lys His Arg Gln Ser Met Thr Tyr Gln Leu Asp Glu Leu Leu Asn Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gln Lys 
465                 470                 475                 480 


Ala Ala Gln Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 
            500                 505                 510         


Ser Ala Asn Thr Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Ser Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asp Asn Lys Leu 
545                 550                 555                 560 


Ser Phe Asp Gln Lys Gln Gln Val Leu Gly Glu Leu Phe Glu Arg His 
                565                 570                 575     


Asn Thr Val Thr Ile Lys Gln Phe Val Asp Asn Leu Leu Ala His Gly 
            580                 585                 590         


Asp Tyr Asp Arg Ile Pro Glu Val Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr Asn Gln Leu Lys Gly Ile Leu His 
    610                 615                 620                 


Glu Ala Ile Asp Asp Ala Asp Lys Gln Thr Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Ala Trp Ser Thr Ile Phe Glu Asp Lys Ala Ile Phe Lys Thr Lys Leu 
                645                 650                 655     


Asn Glu Ile Ser Trp Leu Asn Ala Gly Met Ile Asn Ser Leu Ala Asn 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser His Lys Leu Leu Asn Glu 
        675                 680                 685             


Leu Thr Leu Ser Thr Gly Arg Thr Val Phe Glu Glu Leu Leu Ile Ser 
    690                 695                 700                 


Ser Arg Asn Leu Met Gln Ile Leu Thr Asp Glu Val Leu Lys Gln Lys 
705                 710                 715                 720 


Ile Ala Glu Leu Asn Ala His Glu Leu Lys Ala Ser Gly Ile Tyr Ala 
                725                 730                 735     


Ala Ile Asp Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Ser Val Ile Asp Asp Ile Thr Asn Ala Ala Gly Gln Ala 
        755                 760                 765             


Pro Asn Trp Leu Tyr Ile Glu Thr Ala Asp Gly Asp Gly Val Pro Gly 
    770                 775                 780                 


Lys Arg Thr Asn Ser Arg Gln Arg Lys Ile Gln Glu Ile Tyr Ala Asn 
785                 790                 795                 800 


Ala Ala Gln Glu Leu Ile Thr Gly Ser Val Arg Gly Glu Phe Glu Asp 
                805                 810                 815     


Lys Ile Ala Ser Arg Ala Asp Phe Thr Asp Arg Leu Val Leu Tyr Phe 
            820                 825                 830         


Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Glu Pro Leu Asn Ile Asp 
        835                 840                 845             


Asn Leu Ser Ser Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu Ile 
    850                 855                 860                 


Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val His Pro Leu Val Asn 
865                 870                 875                 880 


Arg Glu Lys Asp Thr Ile Phe Ala Ser Thr Arg Phe Ala Lys Gln Met 
                885                 890                 895     


Asn Gly Met Trp Arg Gln Trp His Ala Ala Gly Leu Ile Ser Ser Arg 
            900                 905                 910         


Lys Leu Arg Asn Leu Gln Met Arg Pro Asp Glu Ile Asp Lys Tyr Ala 
        915                 920                 925             


Ser Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Lys 
    930                 935                 940                 


Leu Thr Glu Gln Ile Val Ala Asp Gln Tyr Pro Asp Thr Lys Ile Ile 
945                 950                 955                 960 


Ala Val Lys Ala Gly Leu Ser Ser Gln Leu Arg Lys Glu Leu Asp Phe 
                965                 970                 975     


Pro Lys Asn Arg Glu Val Asn His Tyr His His Ala Phe Asp Ala Phe 
            980                 985                 990         


Leu Ala Ala Arg Ile Gly Thr Tyr  Leu Leu Lys Arg Tyr  Pro Asn Leu 
        995                 1000                 1005             


Glu Pro  Phe Phe Thr Tyr Gly  Lys Phe Lys Lys Thr  Glu Val Lys 
    1010                 1015                 1020             


Lys Leu  Lys Ser Leu Lys Ser  Leu Lys Ser Phe Asn  Phe Ile Arg 
    1025                 1030                 1035             


Asp Met  Thr His Ala Lys Asp  Lys Ile Val Ala Lys  Glu Thr Gly 
    1040                 1045                 1050             


Glu Ile  Val Trp Asp Asn Ala  Ser Asp Ile Asn Glu  Leu Asp Arg 
    1055                 1060                 1065             


Ile Tyr  Asn Phe Lys Arg Met  Leu Ile Thr His Glu  Val Arg Phe 
    1070                 1075                 1080             


Glu Thr  Ala Ser Leu Phe Lys  Gln Thr Leu Tyr Ala  Ala Lys Asn 
    1085                 1090                 1095             


Ser Lys  Asn Arg Gly Gly Ser  Arg Gln Leu Ile Pro  Lys Lys Lys 
    1100                 1105                 1110             


Gly Tyr  Leu Val Asp Ile Tyr  Gly Gly Tyr Thr Gln  Glu Thr Gly 
    1115                 1120                 1125             


Ser Tyr  Leu Ser Val Val Arg  Leu Thr Lys Lys Ala  Met Tyr Ala 
    1130                 1135                 1140             


Val Val  Lys Val Ser Thr Arg  Asp Ala Ala Lys Leu  Ala Val Ala 
    1145                 1150                 1155             


Lys Ser  Ile Ser Glu Gln Lys  Glu Asn Glu Thr Leu  Lys Lys Ile 
    1160                 1165                 1170             


Ile Asp  Gly Lys Leu Ser Lys  Thr Ser Lys Lys Gly  Lys Thr Thr 
    1175                 1180                 1185             


His Gln  Leu Phe Glu Ile Val  Leu Pro Arg Val Gly  Gln Lys Thr 
    1190                 1195                 1200             


Leu Phe  Lys Asn Ser Lys Tyr  Asn Gln Phe Leu Val  Asn Ser Asp 
    1205                 1210                 1215             


Thr Tyr  Met His Asn Tyr Gln  Glu Leu Trp Met Pro  Arg Glu Tyr 
    1220                 1225                 1230             


Gln Arg  Met Trp Lys Asp Ile  Leu Leu Ser Asn His  Gly Asp Ala 
    1235                 1240                 1245             


Gln Ile  Glu Gly Gln Leu Asp  Gln Ile Phe Lys Phe  Ile Val Ser 
    1250                 1255                 1260             


Gln Val  Asn Ser Tyr Phe Asn  Leu Tyr Asp Ile Asn  Gln Phe Arg 
    1265                 1270                 1275             


Lys Lys  Ile Ala Asp Ala Thr  Asp Lys Phe Ala Lys  Leu Pro Thr 
    1280                 1285                 1290             


His Asp  Thr Asp Asn Ala Arg  Gly Lys Ile Ala Thr  Ile Gly Gln 
    1295                 1300                 1305             


Leu Leu  Ile Gly Leu Gln Ala  Asn Ala Met Arg Ser  Asp Leu Arg 
    1310                 1315                 1320             


Asn Leu  Asp Ile Lys Thr Pro  Phe Gly Leu Leu Gln  Ile Gly Thr 
    1325                 1330                 1335             


Gly Ile  Thr Leu Asp Leu Asp  Thr Ser Ile Ile Tyr  Gln Ser Pro 
    1340                 1345                 1350             


Thr Gly  Leu Phe Glu Arg Glu  Val Pro Leu Thr Asp  Leu 
    1355                 1360                 1365     


<210> 274
<211> 1389
<212> PRT
<213> Lactobacillus casei

<400> 274
Met Ile Ile Arg Thr Tyr Glu Leu Lys Thr Ile Thr Thr Ile Ala Ile 
1               5                   10                  15      


Leu Lys Met Phe Gln Leu Leu Thr Gly Gly Leu Ser Met Thr Lys Leu 
            20                  25                  30          


Gly Lys Pro Tyr Gly Ile Gly Val Asp Ile Gly Ser Asn Ser Ile Gly 
        35                  40                  45              


Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg Leu Lys Gly Lys 
    50                  55                  60                  


Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys Ala Ala Ala Asp 
65                  70                  75                  80  


Arg Arg Ala Ser Arg Thr Thr Arg Arg Arg Leu Ser Arg Asn Arg Trp 
                85                  90                  95      


Arg Leu Ser Phe Leu Arg Asp Phe Phe Glu Ser His Ile Thr Pro Thr 
            100                 105                 110         


Gly Pro Asn Phe Phe Met Arg Gln Lys Tyr Ser Glu Ile Ser Pro Lys 
        115                 120                 125             


Asp Lys Ala Arg Tyr Lys Tyr Glu Lys Arg Leu Phe Asn Asp Arg Thr 
    130                 135                 140                 


Asp Ala Glu Phe Tyr Gln Gln Tyr Pro Thr Met Tyr His Leu Arg Asn 
145                 150                 155                 160 


Arg Leu Leu Thr Asp Pro Ser Lys Ala Asp Val Arg Glu Ile Tyr Phe 
                165                 170                 175     


Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe Leu Thr Ser Gly 
            180                 185                 190         


Tyr Ala Lys Asp Phe Asn Thr Asn Lys Val Ala Leu Asn Glu Ile Phe 
        195                 200                 205             


Pro Ala Leu Gln Asp Ala Tyr Ala Gln Val Tyr Pro Asp Leu Asp Ile 
    210                 215                 220                 


Thr Phe Asp Glu Asn Lys Val Asn Glu Phe Lys Thr Val Leu Leu Asn 
225                 230                 235                 240 


Glu Lys Ala Thr Pro Ser Asp Thr Gln Arg Ala Leu Val Asn Leu Leu 
                245                 250                 255     


Leu Ala Glu Asp Gly Asp Lys Asp Ile Leu Lys Gln Gln Lys Gln Val 
            260                 265                 270         


Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys Thr Lys Leu Asn 
        275                 280                 285             


Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala Thr Val Trp Asn 
    290                 295                 300                 


Phe Ser Leu Gly Gln Leu Asp Asp Lys Trp Ala Gly Ile Glu Ser Ala 
305                 310                 315                 320 


Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gln Ile Arg Asp Leu Tyr 
                325                 330                 335     


Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly Lys Thr Leu Ser 
            340                 345                 350         


Gln Ala Lys Val Asp Asp Tyr Ala Gln His His Glu Asp Leu Glu Leu 
        355                 360                 365             


Phe Lys Asp Tyr Leu Lys Gln Leu Glu Asp Asp Gly Thr Ala Lys Ala 
    370                 375                 380                 


Ile Arg Gln Leu Tyr Asp Arg Tyr Ile Asp Gly Asp Asp Ala Lys Pro 
385                 390                 395                 400 


Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys Glu Val Thr Ala 
                405                 410                 415     


His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg Leu Ala Gln Pro 
            420                 425                 430         


Asp Phe Met Leu Lys Gln Arg Asn Lys Ala Asn Gly Ala Ile Pro Val 
        435                 440                 445             


Gln Met Gln Gln Arg Glu Leu Asp Gln Ile Ile Lys Asn Gln Ser Val 
    450                 455                 460                 


Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu Lys His Arg Lys 
465                 470                 475                 480 


Ser Met Pro Tyr Gln Leu Asp Glu Leu Leu Asn Phe Arg Ile Pro Tyr 
                485                 490                 495     


Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gln Lys Ala Ala Gln Gly 
            500                 505                 510         


Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp Gly Asn Ile Thr 
        515                 520                 525             


Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala Ser Ala Asn Thr 
    530                 535                 540                 


Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu Ile Gly Glu Asp 
545                 550                 555                 560 


Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Arg Tyr Glu Val Leu Asn 
                565                 570                 575     


Glu Leu Asn Asn Val Arg Val Asn Asn Glu Lys Leu Ser Ile Glu Gln 
            580                 585                 590         


Lys Gln Gln Val Ile Arg Glu Leu Phe Glu Arg His Asn Ser Val Thr 
        595                 600                 605             


Ile Lys Gln Phe Ala Glu Asn Leu Arg Ala His Gly Asp Tyr Ala His 
    610                 615                 620                 


Ile Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg Phe Leu Ser Ser 
625                 630                 635                 640 


Leu Ser Thr Tyr Arg Gln Leu Lys Ser Leu Leu Pro Asp Ala Ile Asp 
                645                 650                 655     


Asp Pro Ala Lys Gln Ala Asp Ile Glu Asn Ile Ile Ala Trp Ser Thr 
            660                 665                 670         


Val Phe Glu Asp Ala Ala Ile Phe Lys Thr Lys Leu Lys Glu Ile Asn 
        675                 680                 685             


Trp Leu Asp Ser Gln Thr Ile Thr Lys Leu Ser Asn Ile Arg Tyr Arg 
    690                 695                 700                 


Gly Trp Gly Gln Phe Ser His Lys Phe Leu Asn Gly Leu Thr Leu Gly 
705                 710                 715                 720 


Asn Gly His Thr Ile Ile Gln Glu Leu Phe Leu Ser Asn Asn Asn Leu 
                725                 730                 735     


Met Gln Ile Leu Thr Asp Glu Thr Leu Gln Lys Lys Met Thr Glu Leu 
            740                 745                 750         


Asn Ala Asp Lys Leu Lys Ala Ala Asn Ile Asn Asp Ala Ile Asp Asp 
        755                 760                 765             


Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg Gln Val Leu Arg 
    770                 775                 780                 


Val Ile Glu Asp Ile Lys Arg Ala Ala Asp Gly Gln Asp Pro Ser Trp 
785                 790                 795                 800 


Leu Tyr Val Glu Thr Ala Asp Gly Gly Gly Thr Pro Gly Lys Arg Thr 
                805                 810                 815     


Arg Ala Arg Gln His Gln Leu Gln Glu Ile Tyr Ala Asn Ala Ala His 
            820                 825                 830         


Glu Leu Ile Asp Ser Ala Val Arg Gly Glu Leu Glu Asp Lys Ile Ala 
        835                 840                 845             


Asp Lys Ala Asp Phe Asn Asp Arg Leu Val Leu Tyr Phe Met Gln Gly 
    850                 855                 860                 


Gly Arg Asp Ile Tyr Thr Gly Thr Pro Leu Asn Ile Asp Gln Leu Ser 
865                 870                 875                 880 


Ser Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu Ile Lys Asp Asn 
                885                 890                 895     


Ser Leu Asp Asn Arg Val Leu Val His Ala Ile Ile Asn Arg Glu Lys 
            900                 905                 910         


Asn Ala Thr Phe Ala Ser Thr Ile Tyr Ala Gln Lys Met Asn Ala Thr 
        915                 920                 925             


Trp Arg Gln Trp His Glu Ala Gly Leu Ile Ser Gly Arg Lys Leu Arg 
    930                 935                 940                 


Asn Leu Gln Met Arg Pro Asp Gln Ile Asp Lys Tyr Ala Ser Gly Phe 
945                 950                 955                 960 


Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Lys Leu Thr Glu 
                965                 970                 975     


Gln Ile Val Ala Ala Gln Tyr Pro Glu Thr Lys Ile Ile Ala Val Lys 
            980                 985                 990         


Ala Gly Leu Ser His Gln Leu Arg  Glu Glu Leu Glu Phe  Pro Lys Asn 
        995                 1000                 1005             


Arg Asp  Val Asn His Tyr His  His Ala Phe Asp Ala  Phe Leu Ala 
    1010                 1015                 1020             


Ala Arg  Ile Gly Thr Tyr Leu  Leu Lys Arg Phe Pro  Asn Leu Gln 
    1025                 1030                 1035             


Ala Phe  Phe Thr Tyr Gly Lys  Phe Lys Lys Ala Asp  Val Lys Lys 
    1040                 1045                 1050             


Leu Arg  Gly Phe Asn Phe Ile  Arg Asp Ile Thr His  Ala Glu Asp 
    1055                 1060                 1065             


Lys Ile  Val Val Lys Asp Thr  Gly Glu Val Ile Trp  Asp Lys Lys 
    1070                 1075                 1080             


Arg Asp  Val Asp Glu Leu Asp  Arg Ile Tyr Asn Phe  Lys Arg Met 
    1085                 1090                 1095             


Leu Ile  Thr His Glu Val His  Phe Glu Lys Ala Asp  Leu Phe Lys 
    1100                 1105                 1110             


Gln Thr  Val Tyr Gly Ala Lys  Asp Ser Lys Glu Ala  Gly Gly Lys 
    1115                 1120                 1125             


Lys Gln  Leu Ile Ser Lys Lys  Lys Gly Tyr Pro Val  Asp Ile Tyr 
    1130                 1135                 1140             


Gly Gly  Tyr Thr Gln Glu Thr  Gly Ser Tyr Leu Ser  Val Val Arg 
    1145                 1150                 1155             


Leu Thr  Lys Lys Ala Met Tyr  Ala Val Val Lys Val  Ser Thr Arg 
    1160                 1165                 1170             


Asp Ala  Ala Lys Leu Ala Val  Ala Lys Ser Ile Ser  Glu Gln Lys 
    1175                 1180                 1185             


Glu Asn  Glu Thr Leu Asn Asp  Ile Ile Asp Glu Lys  Leu Ser Lys 
    1190                 1195                 1200             


Ile Ser  Lys Asn Gly Lys Ile  Thr His Glu Leu Phe  Glu Val Val 
    1205                 1210                 1215             


Leu Pro  Arg Val Gly Gln Lys  Thr Leu Phe Lys Asn  Ser Lys Tyr 
    1220                 1225                 1230             


Asn Leu  Phe Leu Val Asn Ser  Asp Thr Tyr Met His  Asn Tyr Gln 
    1235                 1240                 1245             


Glu Leu  Trp Met Pro Arg Glu  Tyr Gln Lys Met Trp  Lys Asp Ile 
    1250                 1255                 1260             


Ser Leu  Ser Lys Tyr Gly Asp  Ala Gln Thr Glu Asp  Gln Leu Asp 
    1265                 1270                 1275             


Gln Ile  Phe Gly Phe Ile Val  Ser Gln Val Asn Ser  Tyr Phe Asn 
    1280                 1285                 1290             


Leu Tyr  Asp Ile Asn Gln Phe  Arg Lys Lys Leu Asn  Asp Ala Ala 
    1295                 1300                 1305             


Asp Lys  Phe Ala Thr Leu Pro  Met Arg Asp Thr Asp  Asp Met Gln 
    1310                 1315                 1320             


Gly Lys  Ile Ala Thr Ile Gly  Gln Leu Leu Ile Gly  Leu Gln Ala 
    1325                 1330                 1335             


Asn Ala  Ala Arg Ser Asp Leu  Arg Asn Leu Asp Ile  Lys Thr Pro 
    1340                 1345                 1350             


Leu Gly  Leu Leu Gln Ile Pro  Asn Gly Ile Ser Leu  Asp Ser Asp 
    1355                 1360                 1365             


Thr Ser  Val Val Tyr Gln Ser  Pro Thr Gly Leu Leu  Glu Arg Glu 
    1370                 1375                 1380             


Val His  Leu Ser Asp Leu 
    1385                 


<210> 275
<211> 1354
<212> PRT
<213> Lactobacillus coryniformis


<220>
<223> Lactobacillus coryniformis subsp. coryniformis KCTC 3167

<400> 275
Met Thr Leu His Tyr Asn Val Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Thr Ile Val Asp Asp Asn Gly Lys Ile Leu Gln Val Lys Gly 
            20                  25                  30          


Lys Asn Gly Tyr Gly Val Arg Val Phe Lys Glu Gly Ala Thr Ala Ala 
        35                  40                  45              


Glu Arg Arg Ile Phe Arg Thr Thr His Arg Arg Leu Lys Arg Arg Lys 
    50                  55                  60                  


Trp Arg Leu Arg Leu Leu Gln Asp Phe Phe Glu Pro Tyr Ile Leu Pro 
65                  70                  75                  80  


Gln Asp Asp Gly Phe Phe Ile Arg Arg Lys Glu Ser Asn Leu Val Leu 
                85                  90                  95      


Asn Asp Arg Asp Glu Asp Thr Ala Ser Leu Phe Asn Asp Arg Ser Asp 
            100                 105                 110         


Arg Asp Phe Tyr Gln Ala Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala 
        115                 120                 125             


Leu Met Thr Glu Lys Arg Gln Phe Asp Val Arg Glu Ile Tyr Leu Ala 
    130                 135                 140                 


Met His His Ile Ile Lys Tyr Arg Gly His Phe Leu Leu Asn Gly Thr 
145                 150                 155                 160 


Val Asn Asn Phe Thr Asn Asn Lys Ile Asp Leu His Ser Asp Phe Glu 
                165                 170                 175     


Glu Leu Asn Ala Leu Leu Leu Asn Val Ile Pro Glu Leu Lys Phe Gln 
            180                 185                 190         


Ile Asp Leu Asp His Ser Thr Met Phe Gln Thr Thr Leu Leu Asn Thr 
        195                 200                 205             


Thr Ile Ser Arg Ser Gly Arg Gln Arg Asp Leu Val Lys Ser Phe Tyr 
    210                 215                 220                 


Asn Gly Ser Asp Asp Lys Gln Leu Ala Lys Gln Gln Lys Ser Val Ala 
225                 230                 235                 240 


Thr Glu Leu Leu Lys Ala Ile Leu Gly Leu Lys Ala Lys Phe His Lys 
                245                 250                 255     


Leu Phe Asn Leu Asp Leu Leu Glu Thr Thr Glu Trp Glu Phe Ser Phe 
            260                 265                 270         


Asp Ala Glu Asp Ile Asp Asp Lys Leu Ala Lys Leu Glu Pro Leu Met 
        275                 280                 285             


Thr Glu Asn Gln Gln Gln Val Met Asp Ile Leu Gln Arg Ile Phe Ala 
    290                 295                 300                 


Ala Ile Thr Leu Asn Gly Ile Val Pro Glu Gly Lys Thr Leu Ser Ala 
305                 310                 315                 320 


Ser Lys Val Asp Ser Tyr Gln Lys His Lys Gln Asp Leu Lys Leu Leu 
                325                 330                 335     


Lys Ala Ile Ala Gln His Ser Asp Lys Lys Thr Ala Thr Val Leu Gln 
            340                 345                 350         


Thr Ala Tyr Asn Glu Tyr Ile Asn Gly Ile Ala Ser Lys Pro Leu Lys 
        355                 360                 365             


Gln Glu Asp Phe Tyr Lys Arg Leu Thr Asn Ala Val Lys Lys Ser Ser 
    370                 375                 380                 


Asp Pro Gln Val Ala Asp Met Leu Ala Leu Ile Asp Gln Glu Lys Phe 
385                 390                 395                 400 


Leu Pro Lys Gln Arg Thr Lys Glu Asn Gly Ala Ile Pro His Gln Leu 
                405                 410                 415     


His Gln Leu Glu Leu Glu Arg Ile Ile Asp Asn Gln Lys Asp Tyr Tyr 
            420                 425                 430         


Pro Trp Leu Ala Glu Leu Asn Pro Asn Gln Ala Arg Gln Lys Val Ala 
        435                 440                 445             


Lys Tyr Lys Leu Ser Glu Leu Val Ala Phe Arg Val Pro Tyr Tyr Val 
    450                 455                 460                 


Gly Pro Leu Ile Glu Pro Glu Val Gln Gln Ala Thr Ser Asn Ala His 
465                 470                 475                 480 


Phe Ala Trp Met Ala Arg Lys Glu Ala Gly Pro Ile Thr Pro Trp Asn 
                485                 490                 495     


Phe Asp Gln Lys Val Asp Arg Asn Val Ser Ala Glu Arg Phe Ile Lys 
            500                 505                 510         


Arg Met Thr Thr Lys Asp Thr Tyr Leu Leu Ala Glu Asp Val Leu Pro 
        515                 520                 525             


Leu His Ser Leu Leu Tyr Gln Arg Phe Ile Val Leu Asn Glu Leu Asn 
    530                 535                 540                 


Asn Val Arg Val Asn Gly Gln Lys Leu Thr Lys Lys Gln Lys Gln Ala 
545                 550                 555                 560 


Val Tyr Gln Asp Leu Phe Lys Arg Gln Pro His Val Thr Lys Lys Gln 
                565                 570                 575     


Phe Lys Ser Tyr Leu Val Gln Thr Gly Glu Phe Ala Glu Ser Ser Lys 
            580                 585                 590         


Ile Glu Gly Leu Ala Asn Glu Thr Ser Phe Asn Ser Gly Leu Thr Thr 
        595                 600                 605             


Glu Asn Glu Leu Arg Lys Ile Phe Gly Ala Gln Leu Asp Glu Ala Arg 
    610                 615                 620                 


Tyr Gln Val Asp Phe Glu Gln Ile Ile Glu Trp Ala Thr Leu Phe Glu 
625                 630                 635                 640 


Asp Ala Lys Ile Leu Arg Thr Lys Leu Ala Glu Ile Thr Trp Leu Thr 
                645                 650                 655     


Thr Glu Gln Ile Glu Lys Leu Ala Gly Ile Arg Tyr Arg Gly Trp Gly 
            660                 665                 670         


Arg Phe Ser Arg Lys Leu Leu Ala Gly Leu Arg Asp Gln Asn Gly Gln 
        675                 680                 685             


Gln Ile Ile Asp Leu Leu Trp Asp Thr Pro Asn Asn Phe Met Val Ile 
    690                 695                 700                 


Val Ser Gln Ala Ala Phe Ser Glu Ala Ile Thr Lys Glu Asn Glu Lys 
705                 710                 715                 720 


Leu Ile Asp Arg Arg Gly Ala Gln Asp Val Ile Thr Asp Leu Tyr Thr 
                725                 730                 735     


Ser Pro Gln Asn Lys Lys Ala Leu Arg Gln Val Leu Ala Ile Val Ala 
            740                 745                 750         


Asp Val Gln Lys Ala Met Gly Gly Val Pro Pro Gln Arg Ile Phe Ile 
        755                 760                 765             


Glu Phe Ala Arg Glu Asp Glu Lys Asn Pro Arg Arg Ser Val Glu Arg 
    770                 775                 780                 


Ser Arg Gln Leu Glu Lys Leu Tyr Gln Thr Ile Ser Asn Glu Phe Leu 
785                 790                 795                 800 


Ile Asn Ser Glu Val Arg Gln Glu Leu Lys Glu Ala Val Asp Gln Lys 
                805                 810                 815     


Val Asn Phe Lys Asp Arg Leu Phe Leu Tyr Phe Leu Gln Gly Gly Val 
            820                 825                 830         


Asp Leu Tyr Ser Gly Lys Arg Ile Asn Ile Asp Gln Leu Ser His Tyr 
        835                 840                 845             


Asp Ile Asp His Ile Leu Pro Gln Ser Phe Ile Lys Asp Asp Ser Leu 
    850                 855                 860                 


Asp Asn Arg Val Leu Val Ser Gln Lys Leu Asn Arg Ser Lys Ser Asp 
865                 870                 875                 880 


Ser Val Pro Leu Ser Glu Phe Ala Asn Tyr Lys Phe Gly Pro Ala Met 
                885                 890                 895     


Gln Ala Lys Trp Leu Gln Leu Lys Glu Ala Gly Leu Leu Ser Lys Arg 
            900                 905                 910         


Lys Tyr Asp Asn Leu Thr Leu Asp Pro Thr Lys Leu Ser Lys Phe Ala 
        915                 920                 925             


Pro Leu Gly Phe Val Asn Arg Gln Leu Val Glu Thr Arg Gln Val Ile 
    930                 935                 940                 


Lys Leu Ala Ala Asn Leu Leu Ala Ser Glu Glu Thr Lys Val Val Thr 
945                 950                 955                 960 


Ile Lys Ala Asn Met Thr His Gln Val Arg Lys Glu Leu Asp Phe Pro 
                965                 970                 975     


Lys Asn Arg Asn Val Asn Asn Tyr His His Ala Phe Asp Ala Tyr Leu 
            980                 985                 990         


Thr Ala Phe Val Gly Ile Phe Leu  Ser Lys Arg Tyr Pro  Lys Leu Lys 
        995                 1000                 1005             


Pro Tyr  Phe Thr Tyr Gly Asp  Phe Gln Lys Gly Asn  Lys Leu Pro 
    1010                 1015                 1020             


Asp Leu  Lys Asn Phe Asn Phe  Leu Tyr Glu Leu Lys  Asn Lys Asp 
    1025                 1030                 1035             


Arg Ser  Ile Asp Ser Asn Thr  Gly Glu Ile Ile Trp  Asp Lys Gln 
    1040                 1045                 1050             


Arg Asp  Leu Ala Tyr Met Asn  Lys Ile Tyr Asn Phe  Lys Lys Val 
    1055                 1060                 1065             


Thr Val  Val His Glu Val Leu  Thr Lys Ser Gly Ala  Leu Tyr Asn 
    1070                 1075                 1080             


Gln Thr  Leu Tyr Lys Ala Ser  Glu Asp Lys Ala Ser  Gly Arg Gly 
    1085                 1090                 1095             


Thr Lys  Gln Leu Ile Arg Lys  Lys Asp Asn Met Pro  Thr Glu Leu 
    1100                 1105                 1110             


Tyr Gly  Gly Tyr Thr Gly Ser  Thr Ser Ala Phe Met  Ser Ile Val 
    1115                 1120                 1125             


Arg Leu  Trp Lys Lys Asp Lys  Pro Tyr Tyr Lys Val  Val Gly Ile 
    1130                 1135                 1140             


Pro Thr  Arg Met Ala Ala Lys  Leu Ala Asn Gln Ala  Gln Leu Leu 
    1145                 1150                 1155             


Asp Tyr  Leu Thr Lys Lys Phe  Thr Thr Arg Lys Leu  Val Lys Lys 
    1160                 1165                 1170             


Thr Gly  Asp Tyr Lys Thr Thr  Val Glu Arg Phe Glu  Leu Val Val 
    1175                 1180                 1185             


Pro Lys  Val Gly Phe Asn Gln  Leu Val Ile Asp Gly  Gly Gln Pro 
    1190                 1195                 1200             


Phe Met  Leu Gly Ser Ala Thr  Tyr Gln Tyr Asn Ala  Arg Glu Leu 
    1205                 1210                 1215             


Phe Ile  Ser Lys Glu Ala Val  Lys Ala Leu Asn Lys  Gln Leu Ser 
    1220                 1225                 1230             


Thr His  Val Asp Leu Val Gln  Val Phe Asp Glu Ile  Leu Val Gln 
    1235                 1240                 1245             


Val Asn  Arg Trp Phe Pro Leu  Tyr Asp Thr Asn Gly  Phe Arg Glu 
    1250                 1255                 1260             


Lys Leu  Ser His Gly Arg Asp  Arg Phe Met Lys Leu  Asn Asp Ser 
    1265                 1270                 1275             


Phe Glu  Glu Lys Ser Asp Thr  Gln Ile Asp Val Leu  Asn Arg Ile 
    1280                 1285                 1290             


Leu Ile  Gly Phe His Ala Asn  Ala Ala Arg Thr Asn  Leu Lys Ile 
    1295                 1300                 1305             


Leu Gly  Leu Gly Thr Asp Leu  Gly Phe Met Thr Gln  Gln Ala Gly 
    1310                 1315                 1320             


Ile Arg  Leu Thr Glu Lys Ala  Ile Leu Val His Gln  Ser Pro Ser 
    1325                 1330                 1335             


Gly Leu  Phe Glu Arg Lys Val  Ala Leu Arg Asp Leu  Lys Gly Leu 
    1340                 1345                 1350             


Arg 
    


<210> 276
<211> 1119
<212> PRT
<213> Lactobacillus coryniformis


<220>
<223> Lactobacillus coryniformis subsp. torquens KCTC 3535

<400> 276
Met Gly Tyr Arg Ile Gly Leu Asp Val Gly Ile Thr Ser Thr Gly Tyr 
1               5                   10                  15      


Ala Val Leu Lys Thr Asp Lys Asn Gly Leu Pro Tyr Lys Ile Leu Thr 
            20                  25                  30          


Leu Asp Ser Val Ile Tyr Pro Arg Ala Glu Asn Pro Gln Thr Gly Ala 
        35                  40                  45              


Ser Leu Ala Glu Pro Arg Arg Ile Lys Arg Gly Leu Arg Arg Arg Thr 
    50                  55                  60                  


Arg Arg Thr Lys Phe Arg Lys Gln Arg Thr Gln Gln Leu Phe Ile His 
65                  70                  75                  80  


Ser Gly Leu Leu Ser Lys Pro Glu Ile Glu Gln Ile Leu Ala Thr Pro 
                85                  90                  95      


Gln Ala Lys Tyr Ser Val Tyr Glu Leu Arg Val Ala Gly Leu Asp Arg 
            100                 105                 110         


Arg Leu Thr Asn Ser Glu Leu Phe Arg Val Leu Tyr Phe Phe Ile Gly 
        115                 120                 125             


His Arg Gly Phe Lys Ser Asn Arg Lys Ala Glu Leu Asn Pro Glu Asn 
    130                 135                 140                 


Glu Ala Asp Lys Lys Gln Met Gly Gln Leu Leu Asn Ser Ile Glu Glu 
145                 150                 155                 160 


Ile Arg Lys Ala Ile Ala Glu Lys Gly Tyr Arg Thr Val Gly Glu Leu 
                165                 170                 175     


Tyr Leu Lys Asp Pro Lys Tyr Asn Asp His Lys Arg Asn Lys Gly Tyr 
            180                 185                 190         


Ile Asp Gly Tyr Leu Ser Thr Pro Asn Arg Gln Met Leu Val Asp Glu 
        195                 200                 205             


Ile Lys Gln Ile Leu Asp Lys Gln Arg Glu Leu Gly Asn Glu Lys Leu 
    210                 215                 220                 


Thr Asp Glu Phe Tyr Ala Thr Tyr Leu Leu Gly Asp Glu Asn Arg Ala 
225                 230                 235                 240 


Gly Ile Phe Gln Ala Gln Arg Asp Phe Asp Glu Gly Pro Gly Ala Gly 
                245                 250                 255     


Pro Tyr Ala Gly Asp Gln Ile Lys Lys Met Val Gly Lys Asp Ile Phe 
            260                 265                 270         


Glu Pro Thr Glu Asp Arg Ala Ala Lys Ala Thr Tyr Thr Phe Gln Tyr 
        275                 280                 285             


Phe Asn Leu Leu Gln Lys Met Thr Ser Leu Asn Tyr Gln Asn Thr Thr 
    290                 295                 300                 


Gly Asp Thr Trp His Thr Leu Asn Gly Leu Asp Arg Gln Ala Ile Ile 
305                 310                 315                 320 


Asp Ala Val Phe Ala Lys Ala Glu Lys Pro Thr Lys Thr Tyr Lys Pro 
                325                 330                 335     


Thr Asp Phe Gly Glu Leu Arg Lys Leu Leu Lys Leu Pro Asp Asp Ala 
            340                 345                 350         


Arg Phe Asn Leu Val Asn Tyr Gly Ser Leu Gln Thr Gln Lys Glu Ile 
        355                 360                 365             


Glu Thr Val Glu Lys Lys Thr Arg Phe Val Asp Phe Lys Ala Tyr His 
    370                 375                 380                 


Asp Leu Val Lys Val Leu Pro Glu Glu Met Trp Gln Ser Arg Gln Leu 
385                 390                 395                 400 


Leu Asp His Ile Gly Thr Ala Leu Thr Leu Tyr Ser Ser Asp Lys Arg 
                405                 410                 415     


Arg Arg Arg Tyr Phe Ala Glu Glu Leu Asn Leu Pro Ala Glu Leu Ile 
            420                 425                 430         


Glu Lys Leu Leu Pro Leu Asn Phe Ser Lys Phe Gly His Leu Ser Ile 
        435                 440                 445             


Lys Ser Met Gln Asn Ile Ile Pro Tyr Leu Glu Met Gly Gln Val Tyr 
    450                 455                 460                 


Ser Glu Ala Thr Thr Asn Thr Gly Tyr Asp Phe Arg Lys Lys Gln Ile 
465                 470                 475                 480 


Ser Lys Asp Thr Ile Arg Glu Glu Ile Thr Asn Pro Val Val Arg Arg 
                485                 490                 495     


Ala Val Thr Lys Thr Ile Lys Ile Val Glu Gln Ile Ile Arg Arg Tyr 
            500                 505                 510         


Gly Lys Pro Asp Gly Ile Asn Ile Glu Leu Ala Arg Glu Leu Gly Arg 
        515                 520                 525             


Asn Phe Lys Glu Arg Gly Asp Ile Gln Lys Arg Gln Asp Lys Asn Arg 
    530                 535                 540                 


Gln Thr Asn Asp Lys Ile Ala Ala Glu Leu Thr Glu Leu Gly Ile Pro 
545                 550                 555                 560 


Val Asn Gly Gln Asn Ile Ile Arg Tyr Lys Leu His Lys Glu Gln Asn 
                565                 570                 575     


Gly Val Asp Pro Tyr Thr Gly Asp Gln Ile Pro Phe Glu Arg Ala Phe 
            580                 585                 590         


Ser Glu Gly Tyr Glu Val Asp His Ile Ile Pro Tyr Ser Ile Ser Trp 
        595                 600                 605             


Asp Asp Ser Tyr Thr Asn Lys Val Leu Thr Ser Ala Lys Cys Asn Arg 
    610                 615                 620                 


Glu Lys Gly Asn Arg Ile Pro Met Val Tyr Leu Ala Asn Asn Glu Gln 
625                 630                 635                 640 


Arg Leu Asn Ala Leu Thr Asn Ile Ala Asp Asn Ile Ile Arg Asn Ser 
                645                 650                 655     


Arg Lys Arg Gln Lys Leu Leu Lys Gln Lys Leu Ser Asp Glu Glu Leu 
            660                 665                 670         


Lys Asp Trp Lys Gln Arg Asn Ile Asn Asp Thr Arg Phe Ile Thr Arg 
        675                 680                 685             


Val Leu Tyr Asn Tyr Phe Arg Gln Ala Ile Glu Phe Asn Pro Glu Leu 
    690                 695                 700                 


Glu Lys Lys Gln Arg Val Leu Pro Leu Asn Gly Glu Val Thr Ser Lys 
705                 710                 715                 720 


Ile Arg Ser Arg Trp Gly Phe Leu Lys Val Arg Glu Asp Gly Asp Leu 
                725                 730                 735     


His His Ala Ile Asp Ala Thr Val Ile Ala Ala Ile Thr Pro Lys Phe 
            740                 745                 750         


Ile Gln Gln Val Thr Lys Tyr Ser Gln His Gln Glu Val Lys Asn Asn 
        755                 760                 765             


Gln Ala Leu Trp His Asp Ala Glu Ile Lys Asp Ala Glu Tyr Ala Ala 
    770                 775                 780                 


Glu Ala Gln Arg Met Asp Ala Asp Leu Phe Asn Lys Ile Phe Asn Gly 
785                 790                 795                 800 


Phe Pro Leu Pro Trp Pro Glu Phe Leu Asp Glu Leu Leu Ala Arg Ile 
                805                 810                 815     


Ser Asp Asn Pro Val Glu Met Met Lys Ser Arg Ser Trp Asn Thr Tyr 
            820                 825                 830         


Thr Pro Ile Glu Ile Ala Lys Leu Lys Pro Val Phe Val Val Arg Leu 
        835                 840                 845             


Ala Asn His Lys Ile Ser Gly Pro Ala His Leu Asp Thr Ile Arg Ser 
    850                 855                 860                 


Ala Lys Leu Phe Asp Glu Lys Gly Ile Val Leu Ser Arg Val Ser Ile 
865                 870                 875                 880 


Thr Lys Leu Lys Ile Asn Lys Lys Gly Gln Val Ala Thr Gly Asp Gly 
                885                 890                 895     


Ile Tyr Asp Pro Glu Asn Ser Asn Asn Gly Asp Lys Val Val Tyr Ser 
            900                 905                 910         


Ala Ile Arg Gln Ala Leu Glu Ala His Asn Gly Ser Gly Glu Leu Ala 
        915                 920                 925             


Phe Pro Asp Gly Tyr Leu Glu Tyr Val Asp His Gly Thr Lys Lys Leu 
    930                 935                 940                 


Val Arg Lys Val Arg Val Ala Lys Lys Val Ser Leu Pro Val Arg Leu 
945                 950                 955                 960 


Lys Asn Lys Ala Ala Ala Asp Asn Gly Ser Met Val Arg Ile Asp Val 
                965                 970                 975     


Phe Asn Thr Gly Lys Lys Phe Val Phe Val Pro Ile Tyr Ile Lys Asp 
            980                 985                 990         


Thr Val Glu Gln Val Leu Pro Asn  Lys Ala Ile Ala Arg  Gly Lys Ser 
        995                 1000                 1005             


Leu Trp  Tyr Gln Ile Thr Glu  Ser Asp Gln Phe Cys  Phe Ser Leu 
    1010                 1015                 1020             


Tyr Pro  Gly Asp Met Val His  Ile Glu Ser Lys Thr  Gly Ile Lys 
    1025                 1030                 1035             


Pro Lys  Tyr Ser Asn Lys Glu  Asn Asn Thr Ser Val  Val Pro Ile 
    1040                 1045                 1050             


Lys Asn  Phe Tyr Gly Tyr Phe  Asp Gly Ala Asp Ile  Ala Thr Ala 
    1055                 1060                 1065             


Ser Ile  Leu Val Arg Ala His  Asp Ser Ser Tyr Thr  Ala Arg Ser 
    1070                 1075                 1080             


Ile Gly  Ile Ala Gly Leu Leu  Lys Phe Glu Lys Tyr  Gln Val Asp 
    1085                 1090                 1095             


Tyr Phe  Gly Arg Tyr His Lys  Val His Glu Lys Lys  Arg Gln Leu 
    1100                 1105                 1110             


Phe Val  Lys Arg Asp Glu 
    1115                 


<210> 277
<211> 1368
<212> PRT
<213> Lactobacillus curvatus


<220>
<223> Lactobacillus curvatus CRL 705

<400> 277
Met Ser Arg Pro Tyr Asn Ile Gly Leu Asp Ile Gly Thr Ser Ser Ile 
1               5                   10                  15      


Gly Trp Ser Val Val Asp Asp Gln Ser Lys Leu Val Ser Val Arg Gly 
            20                  25                  30          


Lys Tyr Gly Tyr Gly Val Arg Leu Tyr Asp Glu Gly Gln Thr Ala Ala 
        35                  40                  45              


Glu Arg Arg Ser Phe Arg Thr Thr Arg Arg Arg Leu Lys Arg Arg Lys 
    50                  55                  60                  


Trp Arg Leu Gly Leu Leu Arg Glu Ile Phe Glu Pro Tyr Ile Thr Pro 
65                  70                  75                  80  


Ile Asp Asp Thr Phe Phe Leu Arg Gln Lys Gln Ser Asn Leu Ser Pro 
                85                  90                  95      


Lys Asp Gln Arg Lys Leu Tyr Thr Gln Thr Ser Leu Phe Asn Asp Arg 
            100                 105                 110         


Thr Asp Arg Ala Phe Tyr Asp Asp Tyr Pro Thr Ile Tyr His Leu Arg 
        115                 120                 125             


Tyr Arg Leu Met Thr Glu Lys Arg Gln Phe Asp Ile Arg Glu Ile Tyr 
    130                 135                 140                 


Leu Ala Met His His Ile Val Lys Tyr Arg Gly His Phe Leu Asn Glu 
145                 150                 155                 160 


Ala Pro Val Ser Ser Phe Lys Ser Ser Glu Ile Asn Leu Val Ala His 
                165                 170                 175     


Phe Asp Arg Leu Asn Thr Ile Phe Ala Asp Leu Phe Ser Glu Ser Gly 
            180                 185                 190         


Phe Gln Leu Glu Thr Asp Lys Leu Ala Glu Val Lys Ala Leu Leu Leu 
        195                 200                 205             


Asp Asn Gln Gln Ser Ala Ser Asn Arg Gln Arg Gln Ala Leu Ser Leu 
    210                 215                 220                 


Ile Tyr Thr Pro Ser Thr Asn Lys Ala Val Glu Lys Gln Asn Lys Ala 
225                 230                 235                 240 


Ile Ala Thr Glu Leu Leu Lys Ala Ile Leu Gly Leu Lys Ala Lys Phe 
                245                 250                 255     


Asn Val Leu Thr Gly Ile Glu Ala Glu Asp Val Lys Ala Trp Thr Leu 
            260                 265                 270         


Thr Phe Asn Ala Glu Asn Phe Asp Glu Glu Met Val Lys Leu Glu Ser 
        275                 280                 285             


Ser Leu Asp Asp Asn Ala His Gln Ile Ile Glu Ser Leu Gln Glu Leu 
    290                 295                 300                 


Tyr Ser Gly Val Leu Leu Ala Gly Ile Val Pro Glu Asn Gln Ser Leu 
305                 310                 315                 320 


Ser Gln Ala Met Ile Thr Lys Tyr Asp Asp His Gln Lys His Leu Lys 
                325                 330                 335     


Met Leu Lys Ala Val Arg Glu Ala Leu Ala Pro Gly Asp Arg Gln Arg 
            340                 345                 350         


Leu Lys Gln Ala Tyr Asp Gln Tyr Val Asp Gly Gln Glu Asn Thr Lys 
        355                 360                 365             


Ala Tyr Ser Lys Glu Asp Phe Tyr Gly Asp Ile Thr Lys Ala Leu Lys 
    370                 375                 380                 


Asn Asn Pro Asp His Pro Ile Val Ser Glu Ile Lys Lys Leu Ile Glu 
385                 390                 395                 400 


Leu Asp Gln Phe Met Pro Lys Gln Arg Thr Lys Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Gln Gln Glu Leu Asp Arg Ile Ile Glu Asn Gln 
            420                 425                 430         


Gln Gln Tyr Tyr Pro Trp Leu Ala Glu Leu Asn Pro Asn Ser Lys Arg 
        435                 440                 445             


Gln Thr Val Ala Lys Tyr Lys Leu Asp Glu Leu Val Ala Phe Arg Val 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ile Thr Ala Glu Gln Gln Arg Gln Ser 
465                 470                 475                 480 


Ser Asp Ala Lys Phe Ala Trp Leu Ile Arg Lys Ala Glu Gly Arg Ile 
                485                 490                 495     


Thr Pro Trp Asn Phe Asp Asp Lys Val Asp Arg Gln Ala Ser Ala Asn 
            500                 505                 510         


Glu Phe Ile Lys Arg Met Thr Thr Thr Asp Thr Tyr Leu Leu Ala Glu 
        515                 520                 525             


Asp Val Leu Pro Lys Gln Ser Leu Ile Tyr Gln Arg Phe Glu Val Leu 
    530                 535                 540                 


Asn Glu Leu Asn Gly Leu Lys Ile Asp Asp Gln Pro Ile Thr Thr Glu 
545                 550                 555                 560 


Leu Lys Gln Ala Ile Phe Thr Asp Leu Phe Met Gln Lys Ile Ser Val 
                565                 570                 575     


Thr Val Lys Asn Ile Gln Asp Tyr Leu Val Ser Glu Lys Arg Tyr Ala 
            580                 585                 590         


Ser Arg Pro Ala Ile Thr Gly Leu Ser Asp Glu Asn Lys Phe Asn Ser 
        595                 600                 605             


Arg Leu Ser Thr Tyr His Asp Leu Lys Met Ile Val Gly Asp Ala Val 
    610                 615                 620                 


Asp Asp Val Asp Lys Gln Ala Asp Leu Glu Lys Cys Ile Glu Trp Ser 
625                 630                 635                 640 


Thr Ile Phe Glu Asp Gly Lys Ile Tyr Ser Ala Lys Leu Asn Glu Ile 
                645                 650                 655     


Asp Trp Leu Thr Asp Gln Gln Arg Val Gln Leu Ala Ala Lys Arg Tyr 
            660                 665                 670         


Arg Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Thr Gln Ile Val Asn 
        675                 680                 685             


Ala Asn Gly Gln Arg Ile Met Asp Leu Leu Trp Asp Thr Thr Asp Asn 
    690                 695                 700                 


Phe Met Arg Ile Val His Ser Glu Asp Phe Asp Lys Leu Ile Thr Glu 
705                 710                 715                 720 


Ala Asn Gln Met Met Leu Ala Glu Asn Asp Val Gln Asp Val Ile Asn 
                725                 730                 735     


Asp Leu Tyr Thr Ser Pro Gln Asn Lys Lys Ala Leu Arg Gln Ile Leu 
            740                 745                 750         


Leu Val Val Asn Asp Ile Gln Lys Ala Met Lys Gly Gln Ala Pro Glu 
        755                 760                 765             


Arg Ile Leu Ile Glu Phe Ala Arg Glu Asp Glu Val Asn Ser Arg Leu 
    770                 775                 780                 


Ser Val Gln Arg Lys Arg Gln Val Glu Gln Val Tyr Gln Asn Ile Ser 
785                 790                 795                 800 


Asn Glu Leu Leu Asn Asn Thr Glu Ile Arg Asn Glu Leu Lys Asp Leu 
                805                 810                 815     


Ser Asn Ser Ala Leu Ser Asn Thr Arg Leu Phe Leu Tyr Phe Met Gln 
            820                 825                 830         


Gly Gly Arg Asp Met Tyr Thr Gly Asp Ser Leu Asn Ile Asp Arg Leu 
        835                 840                 845             


Ser Thr Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Phe Ile Lys Asp 
    850                 855                 860                 


Asn Ser Leu Asp Asn Arg Val Leu Val Ser Gln Lys Met Asn Arg Ser 
865                 870                 875                 880 


Lys Ala Asp Gln Val Pro Thr Asp Phe Thr Ser Val Glu Leu Gly Gln 
                885                 890                 895     


Lys Met Gln Ile Gln Trp Glu Gln Met Leu Arg Ala Gly Leu Ile Thr 
            900                 905                 910         


Lys Lys Lys Tyr Asp Asn Leu Thr Leu Asn Pro Asp His Ile Ser Lys 
        915                 920                 925             


Tyr Ala Met Lys Gly Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln 
    930                 935                 940                 


Val Ile Lys Leu Ala Thr Asn Leu Leu Met Glu Gln Tyr Gly Glu Asp 
945                 950                 955                 960 


Asn Ile Glu Leu Ile Thr Val Lys Ser Gly Leu Thr His Gln Met Arg 
                965                 970                 975     


Thr Glu Phe Asp Phe Pro Lys Asn Arg Asn Leu Asn Asn His His His 
            980                 985                 990         


Ala Phe Asp Ala Tyr Leu Thr Ala  Phe Val Gly Leu Tyr  Leu Leu Lys 
        995                 1000                 1005             


Arg Tyr  Pro Lys Leu Lys Pro  Tyr Phe Val Tyr Gly  Glu Tyr Gln 
    1010                 1015                 1020             


Lys Ala  Ser Gln Gln Asp Lys  Trp Arg Asn Phe Asn  Phe Leu Asn 
    1025                 1030                 1035             


Gly Leu  Lys Lys Asp Glu Leu  Val Asp Glu Asn Thr  Glu Ala Val 
    1040                 1045                 1050             


Ile Trp  Asp Lys Glu Ser Gly  Leu Ala Tyr Leu Asn  Lys Ile Tyr 
    1055                 1060                 1065             


Gln Phe  Lys Lys Ile Leu Val  Thr Arg Gly Val His  Glu Asn Ser 
    1070                 1075                 1080             


Gly Ala  Leu Phe Asn Gln Thr  Leu Tyr Ala Ala Lys  Asp Asp Lys 
    1085                 1090                 1095             


Ala Ser  Gly Gln Gly Gly Lys  Gln Leu Ile Pro Ala  Lys Gln Asp 
    1100                 1105                 1110             


Arg Ser  Thr Ala Leu Tyr Gly  Gly Tyr Ser Gly Lys  Thr Val Ala 
    1115                 1120                 1125             


Tyr Met  Cys Ile Val Arg Ile  Lys Asn Lys Lys Gly  Asp Leu Tyr 
    1130                 1135                 1140             


Lys Val  Cys Gly Val Glu Thr  Ser Trp Leu Ala Gln  Leu Lys Gln 
    1145                 1150                 1155             


Leu Thr  Asp Glu Asp Ser Gln  Lys Ala Phe Leu Glu  Gln Lys Ile 
    1160                 1165                 1170             


Ser Pro  Gln Phe Thr Lys Val  Lys Lys Gln Lys Gly  Asn Ile Ile 
    1175                 1180                 1185             


Glu Ala  Val Glu Glu Phe Glu  Val Ile Ala Pro His  Ile Leu Ile 
    1190                 1195                 1200             


Asn Gln  Arg Phe Phe Asp Asn  Gly Gln Glu Leu Thr  Leu Gly Ser 
    1205                 1210                 1215             


Ala Thr  Tyr Lys His Asn Glu  Gln Glu Leu Ile Leu  Asp Lys Thr 
    1220                 1225                 1230             


Ala Val  Lys Leu Leu Asn Gly  Ala Leu Pro Leu Thr  Gln Ser Glu 
    1235                 1240                 1245             


Glu Leu  Ala Glu Gln Val Tyr  Asp Glu Ile Leu Asp  Gln Val Met 
    1250                 1255                 1260             


His Tyr  Phe Pro Leu Tyr Asp  Thr Asn Gln Phe Arg  Ala Lys Leu 
    1265                 1270                 1275             


Ser Thr  Gly Lys Ala Ala Phe  Met Lys Leu Pro Trp  Lys Ser Gln 
    1280                 1285                 1290             


Trp Asp  Gly Asn Lys Met Val  Gln Val Gly Gln Gln  Val Ile Leu 
    1295                 1300                 1305             


Asp Arg  Ile Leu Ile Gly Leu  His Ala Asn Ala Ala  Met Ser Asp 
    1310                 1315                 1320             


Leu Lys  Val Leu Lys Met Thr  Thr Pro Phe Gly Met  Ile Gln Gln 
    1325                 1330                 1335             


Ser Thr  Gly Ile Thr Leu Ser  Ala Asp Thr Gln Ile  Ile Tyr Gln 
    1340                 1345                 1350             


Ser Pro  Thr Gly Leu Phe Glu  Arg Arg Val Ala Leu  Arg Asp Leu 
    1355                 1360                 1365             


<210> 278
<211> 1126
<212> PRT
<213> Lactobacillus farciminis


<220>
<223> Lactobacillus farciminis KCTC 3681

<400> 278
Met Ala Asp Arg Ile Ser Leu Gly Leu Asp Ile Gly Val Ala Ser Val 
1               5                   10                  15      


Gly Phe Ser Val Leu Asp Ile Asp Lys Gly Lys Val Ile Glu Leu Gly 
            20                  25                  30          


Ala Arg Leu Phe Ser Ala Thr Val Ala Ala Gly Asn Gln Asp Arg Arg 
        35                  40                  45              


Asp Met Arg Gly Ala Arg Arg Leu Leu Asn Arg Asn Lys Gln Arg Arg 
    50                  55                  60                  


Gln Asp Thr Gly Lys Leu Phe Lys Lys Phe Gly Leu Ile Asp Asp Phe 
65                  70                  75                  80  


Asp Lys Gly Ser Phe Tyr Asp Asn Phe Asn Gln Asn Leu Asn Pro Tyr 
                85                  90                  95      


Glu Leu Arg Val Lys Gly Leu Thr Glu Gln Leu Thr Lys Glu Glu Leu 
            100                 105                 110         


Ala Glu Ser Leu Tyr Gln Ile Val Lys His Arg Gly Ile Ser Tyr Ala 
        115                 120                 125             


Leu Lys Asp Ala Asp Val Asp Glu Gly Gly Thr Asp Tyr Ser Val Ser 
    130                 135                 140                 


Leu Lys Ile Asn Ser Gln Glu Leu Ala Glu Lys Thr Pro Ala Gln Ile 
145                 150                 155                 160 


Gln Leu Gln Arg Leu Asn Asp Tyr Gly Lys Val Arg Gly Gln Val Val 
                165                 170                 175     


Ile Gly Asp Asp Pro Asp Asn Gln Lys Val Leu Leu Asn Val Phe Pro 
            180                 185                 190         


Thr Ser Ala Tyr Glu Lys Glu Ala Lys Gln Ile Ile Ala Thr Gln Gln 
        195                 200                 205             


Gln Phe Tyr Pro Glu Ser Leu Thr Asp Lys Phe Thr Glu Glu Tyr Cys 
    210                 215                 220                 


Gln Ile Leu Thr Arg Lys Arg Asp Tyr Phe Val Gly Pro Gly Asn Glu 
225                 230                 235                 240 


Lys Ser Arg Thr Asp Tyr Gly Ile Tyr Lys Thr Asp Gly Arg Thr Leu 
                245                 250                 255     


Asp Asn Leu Phe Glu Glu Leu Ile Gly His Asp Lys Ile Tyr Pro Glu 
            260                 265                 270         


Glu Leu Arg Ala Ser Ala Ala Ser Tyr Thr Ala Gln Leu Phe Asn Val 
        275                 280                 285             


Leu Asn Asp Leu Asn Asn Leu Arg Ile Leu Asn Tyr Glu Asp Gly Lys 
    290                 295                 300                 


Leu Thr Lys Glu Asp Lys Glu Lys Ile Ile Ala Glu Ile Lys Asn Asn 
305                 310                 315                 320 


Thr Thr Thr Ile Asn Met Leu Asn Val Ile Lys Lys Val Ala Gly Cys 
                325                 330                 335     


Ser Lys Asp Asp Ile Lys Gly Phe Arg Val Asn Glu Lys Asp Lys Pro 
            340                 345                 350         


Glu Ile Ser Ser Met Pro Val Tyr Arg Lys Ile His Lys Asp Leu Leu 
        355                 360                 365             


Lys Ala Gly Val Asp Ile Ser Asp Trp Pro Val Glu Phe Ile Asp Glu 
    370                 375                 380                 


Leu Ser Phe Ile Leu Thr Leu Asn Thr Glu Asn Gly Glu Ile Arg Lys 
385                 390                 395                 400 


Gln Leu Asn Asn Arg Leu Ala Pro Lys Phe Asp Phe Leu Asn Ala Asp 
                405                 410                 415     


Leu Ile Gln Leu Ile Ile Asp Asn Lys Asp Ser Phe Glu Ile Lys Thr 
            420                 425                 430         


Asn Asn Lys Trp His Arg Phe Ser Val Lys Thr Met Asn Lys Leu Ile 
        435                 440                 445             


Pro Glu Met Met Glu Arg Pro Val Glu Gln Met Thr Leu Leu Asn Glu 
    450                 455                 460                 


Met Gly Leu Val Lys Lys Asp Lys Lys Arg Phe Glu Asn Asn Lys Tyr 
465                 470                 475                 480 


Leu Pro Tyr Lys Glu Ile Ala Lys Asp Ile Phe Asn Pro Val Ala Ser 
                485                 490                 495     


Lys Ser Val Arg Glu Ala Leu Lys Ile Val Asn Ala Val Leu Lys Lys 
            500                 505                 510         


Tyr Gly His Ile Asp Tyr Leu Val Val Glu Met Pro Arg Asp Lys Asn 
        515                 520                 525             


Leu Lys Glu Glu Gln Asp Asn Ile Lys Glu Phe Gln Asn Lys Asn Lys 
    530                 535                 540                 


Lys Ala Lys Asp Ala Ala Phe Glu Ala Phe Val Lys Ser Val Gly Ser 
545                 550                 555                 560 


Glu Gln Arg Val Lys Glu Ala Leu Ser Lys Asn Arg Lys Leu Gln Met 
                565                 570                 575     


Lys Met Arg Leu Trp Tyr Gln Gln Gln Glu Ile Asp Pro Tyr Asn Gly 
            580                 585                 590         


Lys Thr Ile Asp Ala Thr Asp Leu Ile Asn Asn Pro Asp Lys Phe Glu 
        595                 600                 605             


Ile Asp His Ile Ile Pro Gln Ser Ile Ser Phe Tyr Asp Ser Ile Asn 
    610                 615                 620                 


Asn Lys Thr Leu Cys Phe Ala Ser Met Asn Gln Val Lys Gly Gln Lys 
625                 630                 635                 640 


Thr Pro Tyr Glu Phe Met Leu Glu Gly His Gly Gln Ser Tyr Asp Lys 
                645                 650                 655     


Phe Lys Ala Thr Val Met Ala Asn Lys Asn Phe Gly Lys Ala Lys Arg 
            660                 665                 670         


Ala Asn Tyr Leu Phe Glu Glu Asn Val Ser Asp Ile Glu Thr Arg Lys 
        675                 680                 685             


Arg Phe Leu Ser Arg Asn Leu Val Asp Thr Arg Tyr Ser Ser Arg Val 
    690                 695                 700                 


Val Leu Asn Ser Leu Gln Asp Phe Phe Arg Glu Lys Ser Ala Asp Thr 
705                 710                 715                 720 


Lys Val Thr Val Ile Arg Gly Lys Phe Thr Ser Asn Met Arg Lys His 
                725                 730                 735     


Trp His Ile Asp Lys Thr Arg Glu Thr Phe His His His Ala Ile Asp 
            740                 745                 750         


Ala Ser Ile Ile Ala Ala Thr Pro Phe Leu Arg Met Trp Lys Lys Gly 
        755                 760                 765             


Gly Thr Ile Phe Pro Val Lys Val Gly Glu Glu Ser Ile Asp Ile Glu 
    770                 775                 780                 


Thr Gly Glu Ile Leu Asp Asp Lys Asn Phe Asp Lys Ala Met Tyr Glu 
785                 790                 795                 800 


Glu Pro Tyr Ser Gly Phe Val Ser Glu Ile Met Asn Ala Asp Asp Arg 
                805                 810                 815     


Ile Lys Phe Ser His Gln Val Asp Lys Lys Met Asn Arg Lys Val Ser 
            820                 825                 830         


Asp Ala Thr Ile Tyr Ser Thr Arg Thr Gly Lys Leu Ala Lys Asp Lys 
        835                 840                 845             


Lys Asp Ala Glu Tyr Ile Val Ala Lys Val Lys Asp Ile Tyr Ser Val 
    850                 855                 860                 


Asp Gly Phe Lys Lys Phe Lys Lys Val Tyr Asp Lys Asp Lys Thr Lys 
865                 870                 875                 880 


Phe Leu Leu Tyr Lys Tyr Asp Pro Arg Thr Phe Ser Lys Leu Glu Arg 
                885                 890                 895     


Ile Ile Ser Asp Cys Pro Asp Lys Val Glu Lys Val Gln Thr Asn Gly 
            900                 905                 910         


Lys Val Lys Ala Val Asp Ile Ser Pro Phe Glu Met Tyr Arg Arg Asp 
        915                 920                 925             


His Gly Met Ile Lys Lys Tyr Ser Lys Lys Gly Asn Gly Pro Ala Ile 
    930                 935                 940                 


Lys Gln Leu Lys Tyr Leu Asp Lys Lys Leu Gly Ser His Ile Asp Ile 
945                 950                 955                 960 


Thr Pro Ala Asn Ala Asn Gly Lys His Val Ile Leu Gln Ser Leu Lys 
                965                 970                 975     


Pro Trp Arg Thr Asp Val Tyr Leu Asn His Glu Thr Gly Glu Tyr Glu 
            980                 985                 990         


Ile Met Gly Ile Lys Tyr Ser Asp  Leu Lys Phe Asn Lys  Asn Glu Gly 
        995                 1000                 1005             


Tyr Gly  Ile Lys Lys Asp Lys  Tyr Leu Glu Ile Lys  Lys Val Glu 
    1010                 1015                 1020             


Glu Val  Ser Glu Lys Ser Glu  Phe Met Phe Ser Leu  Tyr Arg Lys 
    1025                 1030                 1035             


Asp Arg  Val Lys Val Gln Asp  Met Lys Thr Gly Glu  Ser Val Glu 
    1040                 1045                 1050             


Leu Leu  Phe Trp Ser Arg Asn  Phe Ser Asn Lys Lys  Tyr Ala Glu 
    1055                 1060                 1065             


Leu Lys  Pro Ile Ser Gln Ala  Glu Asn Asp Lys Lys  Leu Pro Val 
    1070                 1075                 1080             


Tyr Gly  Lys Gly Arg Leu Ile  Lys Arg Leu Ile Pro  Lys Asn Cys 
    1085                 1090                 1095             


Lys Ile  Trp Lys Val Asn Thr  Thr Ile Leu Gly Asp  Pro Tyr Tyr 
    1100                 1105                 1110             


Leu Glu  Lys Glu Ser Asp Ser  Pro Lys Asp Ile Leu  Asp 
    1115                 1120                 1125     


<210> 279
<211> 1356
<212> PRT
<213> Lactobacillus farciminis


<220>
<223> Lactobacillus farciminis KCTC 3681

<400> 279
Met Thr Lys Lys Glu Gln Pro Tyr Asn Ile Gly Leu Asp Ile Gly Thr 
1               5                   10                  15      


Ser Ser Val Gly Trp Ala Val Thr Asn Asp Asn Tyr Asp Leu Leu Asn 
            20                  25                  30          


Ile Lys Lys Lys Asn Leu Trp Gly Val Arg Leu Phe Glu Glu Ala Gln 
        35                  40                  45              


Thr Ala Lys Glu Thr Arg Leu Asn Arg Ser Thr Arg Arg Arg Tyr Arg 
    50                  55                  60                  


Arg Arg Lys Asn Arg Ile Asn Trp Leu Asn Glu Ile Phe Ser Glu Glu 
65                  70                  75                  80  


Leu Ala Lys Thr Asp Pro Ser Phe Leu Ile Arg Leu Gln Asn Ser Trp 
                85                  90                  95      


Val Ser Lys Lys Asp Pro Asp Arg Lys Arg Asp Lys Tyr Asn Leu Phe 
            100                 105                 110         


Ile Asp Gly Pro Tyr Thr Asp Lys Glu Tyr Tyr Arg Glu Phe Pro Thr 
        115                 120                 125             


Ile Phe His Leu Arg Lys Glu Leu Ile Leu Asn Lys Asp Lys Ala Asp 
    130                 135                 140                 


Ile Arg Leu Ile Tyr Leu Ala Leu His Asn Ile Leu Lys Tyr Arg Gly 
145                 150                 155                 160 


Asn Phe Thr Tyr Glu His Gln Lys Phe Asn Ile Ser Asn Leu Asn Asn 
                165                 170                 175     


Asn Leu Ser Lys Glu Leu Ile Glu Leu Asn Gln Gln Leu Ile Lys Tyr 
            180                 185                 190         


Asp Ile Ser Phe Pro Asp Asp Cys Asp Trp Asn His Ile Ser Asp Ile 
        195                 200                 205             


Leu Ile Gly Arg Gly Asn Ala Thr Gln Lys Ser Ser Asn Ile Leu Lys 
    210                 215                 220                 


Asp Phe Thr Leu Asp Lys Glu Thr Lys Lys Leu Leu Lys Glu Val Ile 
225                 230                 235                 240 


Asn Leu Ile Leu Gly Asn Val Ala His Leu Asn Thr Ile Phe Lys Thr 
                245                 250                 255     


Ser Leu Thr Lys Asp Glu Glu Lys Leu Asn Phe Ser Gly Lys Asp Ile 
            260                 265                 270         


Glu Ser Lys Leu Asp Asp Leu Asp Ser Ile Leu Asp Asp Asp Gln Phe 
        275                 280                 285             


Thr Val Leu Asp Ala Ala Asn Arg Ile Tyr Ser Thr Ile Thr Leu Asn 
    290                 295                 300                 


Glu Ile Leu Asn Gly Glu Ser Tyr Phe Ser Met Ala Lys Val Asn Gln 
305                 310                 315                 320 


Tyr Glu Asn His Ala Ile Asp Leu Cys Lys Leu Arg Asp Met Trp His 
                325                 330                 335     


Thr Thr Lys Asn Glu Glu Ala Val Glu Gln Ser Arg Gln Ala Tyr Asp 
            340                 345                 350         


Asp Tyr Ile Asn Lys Pro Lys Tyr Gly Thr Lys Glu Leu Tyr Thr Ser 
        355                 360                 365             


Leu Lys Lys Phe Leu Lys Val Ala Leu Pro Thr Asn Leu Ala Lys Glu 
    370                 375                 380                 


Ala Glu Glu Lys Ile Ser Lys Gly Thr Tyr Leu Val Lys Pro Arg Asn 
385                 390                 395                 400 


Ser Glu Asn Gly Val Val Pro Tyr Gln Leu Asn Lys Ile Glu Met Glu 
                405                 410                 415     


Lys Ile Ile Asp Asn Gln Ser Gln Tyr Tyr Pro Phe Leu Lys Glu Asn 
            420                 425                 430         


Lys Glu Lys Leu Leu Ser Ile Leu Ser Phe Arg Ile Pro Tyr Tyr Val 
        435                 440                 445             


Gly Pro Leu Gln Ser Ala Glu Lys Asn Pro Phe Ala Trp Met Glu Arg 
    450                 455                 460                 


Lys Ser Asn Gly His Ala Arg Pro Trp Asn Phe Asp Glu Ile Val Asp 
465                 470                 475                 480 


Arg Glu Lys Ser Ser Asn Lys Phe Ile Arg Arg Met Thr Val Thr Asp 
                485                 490                 495     


Ser Tyr Leu Val Gly Glu Pro Val Leu Pro Lys Asn Ser Leu Ile Tyr 
            500                 505                 510         


Gln Arg Tyr Glu Val Leu Asn Glu Leu Asn Asn Ile Arg Ile Thr Glu 
        515                 520                 525             


Asn Leu Lys Thr Asn Pro Ile Gly Ser Arg Leu Thr Val Glu Thr Lys 
    530                 535                 540                 


Gln Arg Ile Tyr Asn Glu Leu Phe Lys Lys Tyr Lys Lys Val Thr Val 
545                 550                 555                 560 


Lys Lys Leu Thr Lys Trp Leu Ile Ala Gln Gly Tyr Tyr Lys Asn Pro 
                565                 570                 575     


Ile Leu Ile Gly Leu Ser Gln Lys Asp Glu Phe Asn Ser Thr Leu Thr 
            580                 585                 590         


Thr Tyr Leu Asp Met Lys Lys Ile Phe Gly Ser Ser Phe Met Glu Asp 
        595                 600                 605             


Asn Lys Asn Tyr Asp Gln Ile Glu Glu Leu Ile Glu Trp Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Lys Gln Ile Leu Asn Glu Lys Leu His Ser Ser Lys Tyr 
625                 630                 635                 640 


Ser Tyr Thr Pro Asp Gln Ile Lys Lys Ile Ser Asn Met Arg Tyr Lys 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Lys Lys Ile Leu Met Asp Ile Thr Thr Glu 
            660                 665                 670         


Thr Asn Thr Pro Gln Leu Leu Gln Leu Ser Asn Tyr Ser Ile Leu Asp 
        675                 680                 685             


Leu Met Trp Ala Thr Asn Asn Asn Phe Ile Ser Ile Met Ser Asn Asp 
    690                 695                 700                 


Lys Tyr Asp Phe Lys Asn Tyr Ile Glu Asn His Asn Leu Asn Lys Asn 
705                 710                 715                 720 


Glu Asp Gln Asn Ile Ser Asp Leu Val Asn Asp Ile His Val Ser Pro 
                725                 730                 735     


Ala Leu Lys Arg Gly Ile Thr Gln Ser Ile Lys Ile Val Gln Glu Ile 
            740                 745                 750         


Val Lys Phe Met Gly His Ala Pro Lys His Ile Phe Ile Glu Val Thr 
        755                 760                 765             


Arg Glu Thr Lys Lys Ser Glu Ile Thr Thr Ser Arg Glu Lys Arg Ile 
    770                 775                 780                 


Lys Arg Leu Gln Ser Lys Leu Leu Asn Lys Ala Asn Asp Phe Lys Pro 
785                 790                 795                 800 


Gln Leu Arg Glu Tyr Leu Val Pro Asn Lys Lys Ile Gln Glu Glu Leu 
                805                 810                 815     


Lys Lys His Lys Asn Asp Leu Ser Ser Glu Arg Ile Met Leu Tyr Phe 
            820                 825                 830         


Leu Gln Asn Gly Lys Ser Leu Tyr Ser Glu Glu Ser Leu Asn Ile Asn 
        835                 840                 845             


Lys Leu Ser Asp Tyr Gln Val Asp His Ile Leu Pro Arg Thr Tyr Ile 
    850                 855                 860                 


Pro Asp Asp Ser Leu Glu Asn Lys Ala Leu Val Leu Ala Lys Glu Asn 
865                 870                 875                 880 


Gln Arg Lys Ala Asp Asp Leu Leu Leu Asn Ser Asn Val Ile Asp Arg 
                885                 890                 895     


Asn Leu Glu Arg Trp Thr Tyr Met Leu Asn Asn Asn Met Ile Gly Leu 
            900                 905                 910         


Lys Lys Phe Lys Asn Leu Thr Arg Arg Val Ile Thr Asp Lys Asp Lys 
        915                 920                 925             


Leu Gly Phe Ile His Arg Gln Leu Val Gln Thr Ser Gln Met Val Lys 
    930                 935                 940                 


Gly Val Ala Asn Ile Leu Asp Asn Met Tyr Lys Asn Gln Gly Thr Thr 
945                 950                 955                 960 


Cys Ile Gln Ala Arg Ala Asn Leu Ser Thr Ala Phe Arg Lys Ala Leu 
                965                 970                 975     


Ser Gly Gln Asp Asp Thr Tyr His Phe Lys His Pro Glu Leu Val Lys 
            980                 985                 990         


Asn Arg Asn Val Asn Asp Phe His  His Ala Gln Asp Ala  Tyr Leu Ala 
        995                 1000                 1005             


Ser Phe  Leu Gly Thr Tyr Arg  Leu Arg Arg Phe Pro  Thr Asn Glu 
    1010                 1015                 1020             


Met Leu  Leu Met Asn Gly Glu  Tyr Asn Lys Phe Tyr  Gly Gln Val 
    1025                 1030                 1035             


Lys Glu  Leu Tyr Ser Lys Lys  Lys Lys Leu Pro Asp  Ser Arg Lys 
    1040                 1045                 1050             


Asn Gly  Phe Ile Ile Ser Pro  Leu Val Asn Gly Thr  Thr Gln Tyr 
    1055                 1060                 1065             


Asp Arg  Asn Thr Gly Glu Ile  Ile Trp Asn Val Gly  Phe Arg Asp 
    1070                 1075                 1080             


Lys Ile  Leu Lys Ile Phe Asn  Tyr His Gln Cys Asn  Val Thr Arg 
    1085                 1090                 1095             


Lys Thr  Glu Ile Lys Thr Gly  Gln Phe Tyr Asp Gln  Thr Ile Tyr 
    1100                 1105                 1110             


Ser Pro  Lys Asn Pro Lys Tyr  Lys Lys Leu Ile Ala  Gln Lys Lys 
    1115                 1120                 1125             


Asp Met  Asp Pro Asn Ile Tyr  Gly Gly Phe Ser Gly  Asp Asn Lys 
    1130                 1135                 1140             


Ser Ser  Ile Thr Ile Val Lys  Ile Asp Asn Asn Lys  Ile Lys Pro 
    1145                 1150                 1155             


Val Ala  Ile Pro Ile Arg Leu  Ile Asn Asp Leu Lys  Asp Lys Lys 
    1160                 1165                 1170             


Thr Leu  Gln Asn Trp Leu Glu  Glu Asn Val Lys His  Lys Lys Ser 
    1175                 1180                 1185             


Ile Gln  Ile Ile Lys Asn Asn  Val Pro Ile Gly Gln  Ile Ile Tyr 
    1190                 1195                 1200             


Ser Lys  Lys Val Gly Leu Leu  Ser Leu Asn Ser Asp  Arg Glu Val 
    1205                 1210                 1215             


Ala Asn  Arg Gln Gln Leu Ile  Leu Pro Pro Glu His  Ser Ala Leu 
    1220                 1225                 1230             


Leu Arg  Leu Leu Gln Ile Pro  Asp Glu Asp Leu Asp  Gln Ile Leu 
    1235                 1240                 1245             


Ala Phe  Tyr Asp Lys Asn Ile  Leu Val Glu Ile Leu  Gln Glu Leu 
    1250                 1255                 1260             


Ile Thr  Lys Met Lys Lys Phe  Tyr Pro Phe Tyr Lys  Gly Glu Arg 
    1265                 1270                 1275             


Glu Phe  Leu Ile Ala Asn Ile  Glu Asn Phe Asn Gln  Ala Thr Thr 
    1280                 1285                 1290             


Ser Glu  Lys Val Asn Ser Leu  Glu Glu Leu Ile Thr  Leu Leu His 
    1295                 1300                 1305             


Ala Asn  Ser Thr Ser Ala His  Leu Ile Phe Asn Asn  Ile Glu Lys 
    1310                 1315                 1320             


Lys Ala  Phe Gly Arg Lys Thr  His Gly Leu Thr Leu  Asn Asn Thr 
    1325                 1330                 1335             


Asp Phe  Ile Tyr Gln Ser Val  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1340                 1345                 1350             


His Ile  Glu 
    1355     


<210> 280
<211> 1313
<212> PRT
<213> Lactobacillus fermentum


<220>
<223> Lactobacillus fermentum 28-3-CHN

<400> 280
Met His Tyr Leu Asp Glu Ile Phe Ala Pro His Leu Gln Glu Val Asp 
1               5                   10                  15      


Glu Asn Phe Leu Arg Arg Leu Lys Gln Ser Asn Ile His Pro Glu Asp 
            20                  25                  30          


Pro Ala Lys Asn Gln Ala Phe Ile Gly Lys Leu Leu Phe Pro Asp Leu 
        35                  40                  45              


Leu Lys Lys Asn Glu Arg Gly Tyr Pro Thr Leu Ile Lys Met Arg Asp 
    50                  55                  60                  


Glu Leu Pro Val Glu Gln Arg Ala His Tyr Pro Val Thr Asn Ile Tyr 
65                  70                  75                  80  


Lys Leu Arg Glu Ala Met Ile Asn Glu Asp Arg Gln Phe Asp Leu Arg 
                85                  90                  95      


Glu Val Tyr Leu Ala Val His His Ile Met Lys Tyr Arg Gly His Phe 
            100                 105                 110         


Leu Asn Asn Ala Ser Val Asp Lys Phe Lys Val Gly Arg Ile Asp Phe 
        115                 120                 125             


Tyr Lys Ser Phe Asn Val Leu Asn Glu Ala Tyr Glu Glu Leu Gln Asn 
    130                 135                 140                 


Gly Glu Gly Ser Phe Thr Ile Glu Pro Ser Lys Val Glu Lys Ile Gly 
145                 150                 155                 160 


Gln Leu Leu Leu Asp Thr Lys Met Arg Lys Leu Asn Arg Gln Lys Ala 
                165                 170                 175     


Val Ala Lys Leu Leu Glu Val Lys Val Ala Asp Lys Glu Glu Thr Lys 
            180                 185                 190         


Arg Asn Lys Gln Ile Ala Thr Ala Met Ser Lys Leu Val Leu Gly Tyr 
        195                 200                 205             


Lys Ala Asp Phe Ala Thr Val Ala Met Ala Asn Gly Asn Glu Trp Lys 
    210                 215                 220                 


Ile Asp Leu Ser Ser Glu Thr Ser Glu Asp Glu Ile Glu Lys Phe Arg 
225                 230                 235                 240 


Glu Glu Leu Ser Asp Ala Gln Asn Asp Ile Leu Thr Glu Ile Thr Ser 
                245                 250                 255     


Leu Phe Ser Gln Ile Met Leu Asn Glu Ile Val Pro Asn Gly Met Ser 
            260                 265                 270         


Ile Ser Glu Ser Met Met Asp Arg Tyr Trp Thr His Glu Arg Gln Leu 
        275                 280                 285             


Ala Glu Val Lys Glu Tyr Leu Ala Thr Gln Pro Ala Ser Ala Arg Lys 
    290                 295                 300                 


Glu Phe Asp Gln Val Tyr Asn Lys Tyr Ile Gly Gln Ala Pro Lys Glu 
305                 310                 315                 320 


Arg Gly Phe Asp Leu Glu Lys Gly Leu Lys Lys Ile Leu Ser Lys Lys 
                325                 330                 335     


Glu Asn Trp Lys Glu Ile Asp Glu Leu Leu Lys Ala Gly Asp Phe Leu 
            340                 345                 350         


Pro Lys Gln Arg Thr Ser Ala Asn Gly Val Ile Pro His Gln Met His 
        355                 360                 365             


Gln Gln Glu Leu Asp Arg Ile Ile Glu Lys Gln Ala Lys Tyr Tyr Pro 
    370                 375                 380                 


Trp Leu Ala Thr Glu Asn Pro Ala Thr Gly Glu Arg Asp Arg His Gln 
385                 390                 395                 400 


Ala Lys Tyr Glu Leu Asp Gln Leu Val Ser Phe Arg Ile Pro Tyr Tyr 
                405                 410                 415     


Val Gly Pro Leu Val Thr Pro Glu Val Gln Lys Ala Thr Ser Gly Ala 
            420                 425                 430         


Lys Phe Ala Trp Ala Lys Arg Lys Glu Asp Gly Glu Ile Thr Pro Trp 
        435                 440                 445             


Asn Leu Trp Asp Lys Ile Asp Arg Ala Glu Ser Ala Glu Ala Phe Ile 
    450                 455                 460                 


Lys Arg Met Thr Val Lys Asp Thr Tyr Leu Leu Asn Glu Asp Val Leu 
465                 470                 475                 480 


Pro Ala Asn Ser Leu Leu Tyr Gln Lys Tyr Asn Val Leu Asn Glu Leu 
                485                 490                 495     


Asn Asn Val Arg Val Asn Gly Arg Arg Leu Ser Val Gly Ile Lys Gln 
            500                 505                 510         


Asp Ile Tyr Thr Glu Leu Phe Lys Lys Lys Lys Thr Val Lys Val Ser 
        515                 520                 525             


Asp Val Ala Ser Leu Val Met Ala Lys Thr Arg Gly Val Asn Lys Pro 
    530                 535                 540                 


Ser Val Glu Gly Leu Ser Asp Pro Lys Lys Phe Asn Ser Asn Leu Ala 
545                 550                 555                 560 


Thr Tyr Leu Asp Leu Lys Ser Ile Val Gly Asp Lys Val Asp Asp Asn 
                565                 570                 575     


Arg Tyr Gln Thr Asp Leu Glu Asn Ile Ile Glu Trp Arg Ser Val Phe 
            580                 585                 590         


Glu Asp Gly Glu Ile Phe Ala Asp Lys Leu Thr Glu Val Glu Trp Leu 
        595                 600                 605             


Thr Asp Gln Gln Arg Ser Ala Leu Val Lys Lys Arg Tyr Lys Gly Trp 
    610                 615                 620                 


Gly Arg Leu Ser Lys Lys Leu Leu Thr Gly Ile Val Asp Glu Asn Gly 
625                 630                 635                 640 


Gln Arg Ile Ile Asp Leu Met Trp Asn Thr Asp Gln Asn Phe Met Gln 
                645                 650                 655     


Ile Val Asn Gln Pro Val Phe Lys Glu Gln Ile Asp Gln Leu Asn Gln 
            660                 665                 670         


Lys Ala Ile Thr Asn Asp Gly Met Thr Leu Arg Glu Trp Val Glu Ser 
        675                 680                 685             


Val Leu Asp Gly Ala Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile Trp 
    690                 695                 700                 


Gln Val Val Arg Val Val Glu Asp Ile Val Lys Ala Val Gly Asn Ala 
705                 710                 715                 720 


Pro Lys Ser Ile Ser Ile Glu Phe Ala Arg Asn Glu Gly Asn Lys Gly 
                725                 730                 735     


Glu Ile Thr Arg Ser Arg Arg Thr Gln Leu Gln Lys Leu Phe Glu Asp 
            740                 745                 750         


Gln Ala His Glu Leu Val Lys Asp Thr Ser Leu Thr Glu Glu Leu Glu 
        755                 760                 765             


Lys Ala Pro Asp Leu Ser Asp Arg Tyr Tyr Leu Tyr Phe Thr Gln Gly 
    770                 775                 780                 


Gly Lys Asp Met Tyr Thr Gly Asp Pro Ile Asn Phe Asp Glu Ile Ser 
785                 790                 795                 800 


Thr Lys Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Phe Val Lys Asp 
                805                 810                 815     


Asp Ser Leu Asp Asn Arg Val Leu Val Ser Arg Ala Glu Asn Asn Lys 
            820                 825                 830         


Lys Ser Asp Arg Val Pro Ala Lys Leu Tyr Ala Ala Lys Met Lys Pro 
        835                 840                 845             


Tyr Trp Asn Gln Leu Leu Lys Gln Gly Leu Ile Thr Gln Arg Lys Phe 
    850                 855                 860                 


Glu Asn Leu Thr Met Asp Val Asp Gln Asn Ile Lys Tyr Arg Ser Leu 
865                 870                 875                 880 


Gly Phe Val Lys Arg Gln Leu Val Glu Thr Arg Gln Val Ile Lys Leu 
                885                 890                 895     


Thr Ala Asn Ile Leu Gly Ser Met Tyr Gln Glu Ala Gly Thr Asp Ile 
            900                 905                 910         


Ile Glu Thr Arg Ala Gly Leu Thr Lys Gln Leu Arg Glu Glu Phe Asp 
        915                 920                 925             


Leu Pro Lys Val Arg Glu Val Asn Asp Tyr His His Ala Val Asp Ala 
    930                 935                 940                 


Tyr Leu Thr Thr Phe Ala Gly Gln Tyr Leu Asn Arg Arg Tyr Pro Lys 
945                 950                 955                 960 


Leu Arg Ser Phe Phe Val Tyr Gly Glu Tyr Met Lys Phe Lys His Gly 
                965                 970                 975     


Ser Asp Leu Lys Leu Arg Asn Phe Asn Phe Phe His Glu Leu Met Glu 
            980                 985                 990         


Gly Asp Lys Ser Gln Gly Lys Val  Val Asp Gln Gln Thr  Gly Glu Leu 
        995                 1000                 1005             


Ile Thr  Thr Arg Asp Glu Val  Ala Lys Ser Phe Asp  Arg Leu Leu 
    1010                 1015                 1020             


Asn Met  Lys Tyr Met Leu Val  Ser Lys Glu Val His  Asp Arg Ser 
    1025                 1030                 1035             


Asp Gln  Leu Tyr Gly Ala Thr  Ile Val Thr Ala Lys  Glu Ser Gly 
    1040                 1045                 1050             


Lys Leu  Thr Ser Pro Ile Glu  Ile Lys Lys Lys Arg  Pro Val Asp 
    1055                 1060                 1065             


Leu Tyr  Gly Ala Tyr Thr Asn  Gly Thr Ser Ala Phe  Met Thr Ile 
    1070                 1075                 1080             


Ile Lys  Phe Thr Gly Asn Lys  Pro Lys Tyr Lys Val  Ile Gly Val 
    1085                 1090                 1095             


Pro Thr  Thr Ser Ala Val Gly  Leu Lys Arg Val Gly  Lys Pro Gly 
    1100                 1105                 1110             


Ser Glu  Ser Tyr Asn Gln Glu  Leu His Arg Ile Ile  Lys Ser Asn 
    1115                 1120                 1125             


Pro Lys  Val Lys Lys Asp Phe  Glu Ile Val Val Pro  His Val Ser 
    1130                 1135                 1140             


Tyr Ser  Gln Leu Ile Val Asp  Asp Asp Cys Lys Phe  Thr Leu Ala 
    1145                 1150                 1155             


Ser Asp  Thr Tyr Gln His Pro  Ala Thr Gln Leu Val  Leu Ser Lys 
    1160                 1165                 1170             


Glu Ser  Met Glu Ile Ile Ala  Asp Asp Phe Lys Phe  Val Lys Glu 
    1175                 1180                 1185             


Asn Thr  Ala Thr Ala Asp Glu  Gln Leu Val Arg Val  Phe Asp Glu 
    1190                 1195                 1200             


Ile Val  Asn Gln Met Asn His  Tyr Phe Thr Ile Phe  Asp Gln Arg 
    1205                 1210                 1215             


Ser Asn  Arg Gln Lys Val Thr  Lys Ala Arg Asp Lys  Phe Val Ser 
    1220                 1225                 1230             


Leu Pro  Thr Glu Ser Glu Tyr  Glu Gly Ala Lys Lys  Thr Gln Val 
    1235                 1240                 1245             


Gly Lys  Thr Glu Val Ile Thr  Asn Leu Leu Met Gly  Leu His Ala 
    1250                 1255                 1260             


Asn Ser  Ala Gln Gly Asp Leu  Lys Val Leu Gly Leu  Ser Thr Phe 
    1265                 1270                 1275             


Gly Phe  Phe Gln Ser Ser Gly  Gly Leu Asn Leu Ser  Glu Asp Ala 
    1280                 1285                 1290             


Met Ile  Val Tyr Gln Ser Pro  Thr Gly Leu Phe Glu  Arg Arg Ile 
    1295                 1300                 1305             


Cys Leu  Lys Asp Ile 
    1310             


<210> 281
<211> 1381
<212> PRT
<213> Lactobacillus fermentum


<220>
<223> Lactobacillus fermentum ATCC 14931

<400> 281
Met Asp Tyr Val Lys Glu Tyr His Ile Gly Leu Asp Ile Gly Thr Ser 
1               5                   10                  15      


Ser Ile Gly Trp Ala Val Thr Asp Ser Gln Phe Lys Leu Met Arg Ile 
            20                  25                  30          


Lys Gly Lys Thr Ala Ile Gly Val Arg Leu Phe Glu Glu Gly Lys Thr 
        35                  40                  45              


Ala Ala Glu Arg Arg Thr Phe Arg Thr Thr Arg Arg Arg Leu Lys Arg 
    50                  55                  60                  


Arg Lys Trp Arg Leu His Tyr Leu Asp Lys Ile Phe Ala Pro His Leu 
65                  70                  75                  80  


Gln Glu Val Asp Glu Asn Phe Leu Arg Arg Leu Lys Gln Ser Asn Ile 
                85                  90                  95      


His Pro Glu Asp Pro Ala Lys Asn Gln Ala Phe Ile Gly Lys Leu Leu 
            100                 105                 110         


Phe Pro Asp Leu Leu Lys Lys Asn Glu Arg Gly Tyr Pro Thr Leu Ile 
        115                 120                 125             


Lys Met Arg Asp Glu Leu Pro Val Glu Gln Arg Ala His Tyr Pro Val 
    130                 135                 140                 


Thr Asn Ile Tyr Lys Leu Arg Glu Ala Met Ile Asn Glu Asp Arg Gln 
145                 150                 155                 160 


Phe Asp Leu Arg Glu Val Tyr Leu Ala Val His His Ile Val Lys Tyr 
                165                 170                 175     


Arg Gly His Phe Leu Asn Asn Ala Ser Val Asp Lys Phe Lys Val Gly 
            180                 185                 190         


Arg Ile Asp Phe Asp Lys Ser Phe Asn Val Leu Asn Glu Ala Tyr Glu 
        195                 200                 205             


Glu Leu Gln Asn Gly Glu Gly Ser Phe Thr Ile Glu Pro Ser Lys Val 
    210                 215                 220                 


Glu Lys Ile Gly Gln Leu Leu Leu Asp Thr Lys Met Arg Lys Leu Asp 
225                 230                 235                 240 


Arg Gln Lys Ala Val Ala Lys Leu Leu Glu Val Lys Val Ala Asp Lys 
                245                 250                 255     


Glu Glu Thr Lys Arg Asn Lys Gln Ile Ala Thr Ala Met Ser Lys Leu 
            260                 265                 270         


Val Leu Gly Tyr Lys Ala Asp Phe Ala Thr Val Ala Met Ala Asn Gly 
        275                 280                 285             


Asn Glu Trp Lys Ile Asp Leu Ser Ser Glu Thr Ser Glu Asp Glu Ile 
    290                 295                 300                 


Glu Lys Phe Arg Glu Glu Leu Ser Asp Ala Gln Asn Asp Ile Leu Thr 
305                 310                 315                 320 


Glu Ile Thr Ser Leu Phe Ser Gln Ile Met Leu Asn Ala Ile Val Pro 
                325                 330                 335     


Asn Gly Met Ser Ile Ser Glu Ser Met Met Asp Arg Tyr Trp Thr His 
            340                 345                 350         


Glu Arg Gln Leu Ala Glu Val Lys Glu Tyr Leu Ala Thr Gln Pro Ala 
        355                 360                 365             


Ser Ala Arg Lys Glu Phe Asp Gln Val Tyr Asn Lys Tyr Ile Gly Gln 
    370                 375                 380                 


Val Pro Lys Glu Lys Gly Phe Asp Leu Glu Lys Gly Leu Lys Lys Ile 
385                 390                 395                 400 


Leu Ser Lys Lys Glu Asn Trp Lys Glu Ile Asp Glu Leu Leu Lys Ala 
                405                 410                 415     


Gly Asp Phe Leu Pro Lys Gln Arg Thr Ser Ala Asn Gly Val Ile Pro 
            420                 425                 430         


His Gln Met His Gln Gln Glu Leu Asp Arg Ile Ile Glu Lys Gln Ala 
        435                 440                 445             


Lys Tyr Tyr Pro Trp Leu Ala Thr Glu Asn Pro Ala Thr Gly Glu Arg 
    450                 455                 460                 


Asp Arg His Gln Ala Lys Tyr Glu Leu Asp Gln Leu Val Ser Phe Arg 
465                 470                 475                 480 


Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Pro Glu Val Gln Lys Ala 
                485                 490                 495     


Thr Ser Gly Ala Lys Phe Ala Trp Ala Lys Arg Lys Glu Asp Gly Glu 
            500                 505                 510         


Ile Thr Pro Trp Asn Leu Trp Asp Lys Ile Asp Arg Ala Glu Ser Ala 
        515                 520                 525             


Glu Ala Phe Ile Lys Arg Met Thr Val Lys Asp Thr Tyr Leu Leu Asn 
    530                 535                 540                 


Glu Asp Val Leu Pro Ala Asn Ser Leu Leu Tyr Gln Lys Tyr Asn Val 
545                 550                 555                 560 


Leu Asn Glu Leu Asn Asn Val Arg Val Asn Gly Arg Arg Leu Ser Val 
                565                 570                 575     


Gly Ile Lys Gln Asp Ile Tyr Thr Glu Leu Phe Lys Lys Lys Lys Thr 
            580                 585                 590         


Val Lys Ala Gly Asp Val Ala Ser Leu Val Met Ala Lys Thr Arg Gly 
        595                 600                 605             


Val Asn Lys Pro Ser Val Glu Gly Leu Ser Asp Pro Lys Lys Phe Asn 
    610                 615                 620                 


Ser Asn Leu Ala Thr Tyr Leu Asp Leu Lys Ser Ile Met Gly Asp Lys 
625                 630                 635                 640 


Val Asp Asp Asn Arg Tyr Gln Met Asp Leu Glu Asn Ile Ile Glu Trp 
                645                 650                 655     


Arg Ser Val Phe Glu Asp Gly Glu Ile Phe Ala Asp Lys Leu Thr Glu 
            660                 665                 670         


Val Glu Trp Leu Thr Asp Glu Gln Arg Ser Ala Leu Val Lys Lys Arg 
        675                 680                 685             


Tyr Lys Gly Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Gly Ile Val 
    690                 695                 700                 


Asp Glu Asn Gly Gln Arg Ile Ile Asp Leu Met Trp Asn Thr Asp Gln 
705                 710                 715                 720 


Asn Phe Met Gln Ile Val Asn Gln Pro Val Phe Lys Glu Gln Ile Asp 
                725                 730                 735     


Gln Leu Asn Gln Lys Ala Ile Thr Asn Asp Gly Met Thr Leu Arg Glu 
            740                 745                 750         


Arg Val Glu Ser Val Leu Asp Asp Ala Tyr Thr Ser Pro Gln Asn Lys 
        755                 760                 765             


Lys Ala Ile Trp Gln Val Val Arg Val Val Glu Asp Ile Val Lys Ala 
    770                 775                 780                 


Val Gly Asn Ala Pro Lys Ser Ile Ser Ile Glu Phe Ala Arg Asn Glu 
785                 790                 795                 800 


Gly Asn Lys Gly Glu Ile Thr Arg Ser Arg Arg Thr Gln Leu Gln Lys 
                805                 810                 815     


Leu Phe Glu Asp Gln Ala His Glu Leu Val Lys Asp Thr Ser Leu Thr 
            820                 825                 830         


Glu Glu Leu Glu Lys Ala Pro Asp Leu Ser Asp Arg Tyr Tyr Phe Tyr 
        835                 840                 845             


Phe Thr Gln Gly Gly Lys Asp Met Tyr Thr Gly Asp Pro Ile Asn Phe 
    850                 855                 860                 


Asp Glu Ile Ser Thr Lys Tyr Asp Ile Asp His Ile Leu Pro Gln Ser 
865                 870                 875                 880 


Phe Val Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Val Ser Arg Ala 
                885                 890                 895     


Glu Asn Asn Lys Lys Ser Asp Arg Val Pro Ala Lys Leu Tyr Ala Ala 
            900                 905                 910         


Lys Met Lys Pro Tyr Trp Asn Gln Leu Leu Lys Gln Gly Leu Ile Thr 
        915                 920                 925             


Gln Arg Lys Phe Glu Asn Leu Thr Met Asp Val Asp Gln Asn Ile Lys 
    930                 935                 940                 


Tyr Arg Ser Leu Gly Phe Val Lys Arg Gln Leu Val Glu Thr Arg Gln 
945                 950                 955                 960 


Val Ile Lys Leu Thr Ala Asn Ile Leu Gly Ser Met Tyr Gln Glu Ala 
                965                 970                 975     


Gly Thr Asp Ile Ile Glu Thr Arg Ala Gly Leu Thr Lys Gln Leu Arg 
            980                 985                 990         


Glu Glu Phe Asp Leu Pro Lys Val  Arg Glu Val Asn Asp  Tyr His His 
        995                 1000                 1005             


Ala Val  Asp Ala Tyr Leu Thr  Thr Phe Ala Gly Gln  Tyr Leu Asn 
    1010                 1015                 1020             


Arg Arg  Tyr Pro Lys Leu Arg  Ser Phe Phe Val Tyr  Gly Glu Tyr 
    1025                 1030                 1035             


Met Lys  Phe Lys His Gly Ser  Asp Leu Lys Leu Arg  Asn Phe Asn 
    1040                 1045                 1050             


Phe Phe  His Glu Leu Met Glu  Gly Asp Lys Ser Gln  Gly Lys Val 
    1055                 1060                 1065             


Val Asp  Gln Gln Thr Gly Glu  Leu Ile Thr Thr Arg  Asp Glu Val 
    1070                 1075                 1080             


Ala Lys  Ser Phe Asp Arg Leu  Leu Asn Met Lys Tyr  Met Leu Val 
    1085                 1090                 1095             


Ser Lys  Glu Val His Asp Arg  Ser Asp Gln Leu Tyr  Gly Ala Thr 
    1100                 1105                 1110             


Ile Val  Thr Ala Lys Glu Ser  Gly Lys Leu Thr Ser  Pro Ile Glu 
    1115                 1120                 1125             


Ile Lys  Lys Asn Arg Pro Val  Asp Leu Tyr Gly Ala  Tyr Thr Asn 
    1130                 1135                 1140             


Gly Thr  Ser Ala Phe Met Thr  Ile Ile Lys Phe Thr  Gly Asn Lys 
    1145                 1150                 1155             


Pro Lys  Tyr Lys Val Ile Gly  Val Pro Thr Thr Ser  Ala Val Gly 
    1160                 1165                 1170             


Leu Lys  Arg Val Gly Lys Pro  Gly Ser Glu Ser Tyr  Asn Gln Glu 
    1175                 1180                 1185             


Leu His  Arg Ile Ile Lys Ser  Asn Pro Lys Val Lys  Lys Asp Phe 
    1190                 1195                 1200             


Glu Ile  Val Val Pro His Val  Ser Tyr Ser Gln Leu  Ile Val Asp 
    1205                 1210                 1215             


Gly Asp  Cys Lys Phe Thr Leu  Ala Ser Asp Thr Tyr  Gln His Pro 
    1220                 1225                 1230             


Ala Thr  Gln Leu Val Leu Ser  Lys Glu Ser Met Glu  Ile Ile Ala 
    1235                 1240                 1245             


Asp Asp  Phe Lys Phe Val Lys  Glu Asn Pro Ala Thr  Ala Asp Glu 
    1250                 1255                 1260             


Gln Leu  Val Arg Val Phe Asp  Glu Ile Val Asn Gln  Met Asn His 
    1265                 1270                 1275             


Tyr Phe  Thr Ile Phe Asp Gln  Arg Ser Asn Arg Gln  Lys Val Thr 
    1280                 1285                 1290             


Lys Ala  Arg Asp Lys Phe Val  Ser Leu Pro Thr Glu  Ser Glu Tyr 
    1295                 1300                 1305             


Glu Gly  Ala Lys Lys Thr Gln  Val Gly Lys Thr Glu  Val Ile Thr 
    1310                 1315                 1320             


Asn Leu  Leu Met Gly Leu His  Ala Asn Ala Ala Gln  Gly Asp Leu 
    1325                 1330                 1335             


Lys Val  Leu Gly Leu Ser Thr  Phe Gly Phe Phe Gln  Ser Ser Gly 
    1340                 1345                 1350             


Gly Leu  Asn Leu Ser Glu Asp  Ala Met Ile Val Tyr  Gln Ser Pro 
    1355                 1360                 1365             


Thr Gly  Leu Phe Glu Arg Arg  Ile Cys Leu Lys Asp  Ile 
    1370                 1375                 1380     


<210> 282
<211> 1327
<212> PRT
<213> Lactobacillus florum


<220>
<223> Lactobacillus florum 2F

<400> 282
Met Thr Glu Gln Gln Gln Pro Tyr Asn Ile Gly Leu Asp Ile Gly Thr 
1               5                   10                  15      


Ser Ser Ile Gly Trp Ala Val Thr Asp Gln Asn Asp Lys Leu Leu His 
            20                  25                  30          


Ile Arg Gly His Asn Gly Ile Gly Val Arg Leu Phe Lys Glu Gly Glu 
        35                  40                  45              


Ser Ala Ala Glu Arg Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Arg Arg Trp Arg Leu Arg Phe Leu Asp Arg Ile Phe Asp Ala Glu 
65                  70                  75                  80  


Leu Ala Lys Val Asp Pro Asn Phe Leu Ala Arg Leu Lys Gln Ser Asn 
                85                  90                  95      


Ile Ser Pro Leu Asp Pro Asn Lys Gln Met Phe Gly Asn Ile Leu Phe 
            100                 105                 110         


Asp Asp Pro Gln Phe Asp Asp Gln Lys Phe His Gln Gln Tyr Pro Thr 
        115                 120                 125             


Ile Tyr His Leu Arg Ser Ala Leu Ala Gln Pro Asp Ala Pro Gln Ala 
    130                 135                 140                 


Asp Val Arg Leu Ile Tyr Leu Ala Leu His His Met Ile Lys Phe Arg 
145                 150                 155                 160 


Gly His Phe Leu Asn Gly Ala Ala Val Glu Lys Phe His Gly Gly Gln 
                165                 170                 175     


Leu His Leu Glu Ser Glu Phe Gln Glu Leu Asn Gln Ile Phe Ser Asn 
            180                 185                 190         


Gln Gln Arg Asp His Val Gln Leu Gln Thr Ser Ser Leu Asp Glu Val 
        195                 200                 205             


Ala Thr Ile Leu Lys Asp Asn Gln Arg Thr Pro Ser Asp Arg Gln Arg 
    210                 215                 220                 


Glu Leu Ser Ala Arg Leu Phe Val Pro Val Asp Lys Thr Ile Asp Lys 
225                 230                 235                 240 


Glu Asn Lys Lys Leu Ala Thr Glu Leu Leu Lys Ala Val Leu Gly Leu 
                245                 250                 255     


Lys Ala Lys Phe Asp Val Ile Leu Gly Val Glu Ala Thr Asp Pro Gln 
            260                 265                 270         


Ala Phe Lys Leu Gln Phe Ser Ser Asp Asp Phe Asp Asp Lys Ile Ala 
        275                 280                 285             


Glu Leu Ala Ser Glu Leu Thr Asp Glu Ala Asn Glu Ile Leu Thr Val 
    290                 295                 300                 


Leu Gln Arg Leu Tyr Phe Ser Leu Asn Leu Ala Asp Ile Leu Thr Asn 
305                 310                 315                 320 


Arg Gln Thr Lys Gln Val Ala Asp Ser Ile Ser Thr Ala Met Ile Asn 
                325                 330                 335     


Arg Tyr Asp Asp His Lys His His Leu Lys Met Leu Lys Glu Leu Glu 
            340                 345                 350         


Ala Gln Val Thr Gln Glu Gln Arg Asp Gly Leu Lys Lys Ala Tyr Asp 
        355                 360                 365             


Glu Tyr Ile Asp Gly Asp Lys Pro Thr Ile Asp Thr Phe Tyr Thr Asn 
    370                 375                 380                 


Ile Lys Lys Asn Leu Asp Asp Ser Glu Leu Ala Asn Gln Ile Lys Ser 
385                 390                 395                 400 


Leu Ile Asp Leu Gln Ala Phe Met Pro Lys Gln Arg Ser Lys Glu Asn 
                405                 410                 415     


Gly Ser Ile Pro His Gln Leu His Gln Arg Glu Leu Asp Gln Leu Ile 
            420                 425                 430         


Glu Val Gln Gly Lys Tyr Tyr Pro Trp Leu Leu Ala Ala Lys Asp Lys 
        435                 440                 445             


Leu Asp Ala Leu Ile Ala Phe Arg Val Pro Tyr Tyr Val Gly Pro Met 
    450                 455                 460                 


Ile Asp Pro Asn Gln Ser Asp Asp Pro Gln Asn Thr Lys Phe Ala Trp 
465                 470                 475                 480 


Met Val Arg Lys Glu Ala Gly Glu Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Lys Val Asp Lys Thr Ser Ser Ala Thr Asn Phe Ile Lys Arg Met Thr 
            500                 505                 510         


Thr Thr Asp Thr Tyr Leu Leu Gly Glu Pro Val Leu Pro Lys Asn Ser 
        515                 520                 525             


Leu Leu Tyr Gln Gln Phe Thr Val Leu Asn Glu Leu Asn Lys Leu Lys 
    530                 535                 540                 


Val Asn Gly Lys Ala Leu Thr Val Asp Gln Lys Lys Tyr Leu Tyr Glu 
545                 550                 555                 560 


His Val Cys Lys Lys Gln Arg Arg Val Thr Leu Lys Lys Leu Ser Asp 
                565                 570                 575     


Cys Leu Met Ala Arg Gly Asp Phe Pro Met Gly Ala Ile Phe Thr Gly 
            580                 585                 590         


Thr Thr Asp Gln Lys Asn Met Asn Asn Thr Leu Lys Thr Tyr Gln Asp 
        595                 600                 605             


Phe Gln Glu Ile Phe Gly Asp Glu Ile Asp Asn Pro Asp Arg Gln Val 
    610                 615                 620                 


Asp Phe Glu Lys Met Ile Glu Trp Ser Ala Ile Phe Glu Asp Arg Glu 
625                 630                 635                 640 


Ile Phe Lys Leu Lys Leu Ala Glu Leu Asn Trp Leu Thr Ser Glu Gln 
                645                 650                 655     


Leu Glu Arg Val Ser Lys Lys Arg Tyr Gln Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Gln Lys Leu Leu Thr His Ile Val Asn Glu Asn Gly Glu Arg Ile Ile 
        675                 680                 685             


Asp Gln Leu Trp Asn Thr Asn Gln Asn Phe Met Glu Ile Met Gly Gln 
    690                 695                 700                 


Asp Ser Val Lys Gln Ala Ile Gln Glu His Asn Gly Ala Asn Val Ala 
705                 710                 715                 720 


Gln Thr Gly Ile Asn Glu Thr Ile Asp Glu Leu Tyr Thr Ser Pro Gln 
                725                 730                 735     


Asn Lys Lys Ala Ile Arg Gln Ile Leu Leu Val Val Asp Asp Ile Lys 
            740                 745                 750         


Lys Ala Val Gly Tyr Ala Pro Ala Asn Ile Met Met Glu Phe Ala Arg 
        755                 760                 765             


Glu Asp Arg Asp Asp His Arg Leu Ile Ala Ser Arg Ala Arg Gln Leu 
    770                 775                 780                 


Glu Lys Thr Tyr Gln Glu Ile Ser Lys Asn Trp Phe Asp Asn Glu Ser 
785                 790                 795                 800 


Val Thr Gln Glu Leu Lys Asp Gln Ile Lys Asn Lys Thr Lys Phe Thr 
                805                 810                 815     


Asp Arg Leu Tyr Leu Tyr Phe Ile Gln Gly Gly Ile Asp Leu Tyr Thr 
            820                 825                 830         


Gly His Pro Leu Asn Ile Asp Gln Leu Ser Ser Tyr Asp Ile Asp His 
        835                 840                 845             


Ile Leu Pro Gln Ser Phe Leu Leu Asp Asn Ser Leu Asn Asn Arg Val 
    850                 855                 860                 


Leu Thr Ser Gln Ala Glu Asn Arg Val His Lys Glu Asp Arg Leu Pro 
865                 870                 875                 880 


Gly Glu Thr Val Ala Asn Lys Met Arg Pro Thr Trp Lys Met Met Arg 
                885                 890                 895     


Glu Gln Gly Leu Met Thr Gln Arg Lys Tyr Asn Asn Leu Thr Leu Lys 
            900                 905                 910         


Pro Asp Gln Ile Ser Lys Phe Asn Asn Arg Gly Gln Phe Ile Asn Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Val Ile Lys Leu Ala Ala Asp Ile Met 
    930                 935                 940                 


Ser Gln Lys Tyr Gln Ala Asp Gln Thr Lys Val Val Thr Val Lys Ala 
945                 950                 955                 960 


Asn Leu Thr His His Met Arg Glu Lys Phe Asn Phe Tyr Lys Ser Arg 
                965                 970                 975     


Asn Val Asn Asp Tyr His His Ala Phe Asp Ala Tyr Leu Thr Leu Phe 
            980                 985                 990         


Val Gly Asn Trp Leu Leu Lys Glu  Tyr Pro Lys Leu Gln  Pro Tyr Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Phe Ala Lys  Thr Gly Thr Asn Asn  Leu Lys Ser 
    1010                 1015                 1020             


Phe Asn  Phe Leu Tyr Arg Phe  Glu Arg Asp His Lys  Leu Asn Asp 
    1025                 1030                 1035             


Lys Gly  Ala Ile Asp Thr Asp  Lys Asp Gln Gln Leu  Gly Tyr Met 
    1040                 1045                 1050             


Lys Arg  Ile Tyr Arg Phe Lys  Lys Met Leu Val Thr  Lys Gln Leu 
    1055                 1060                 1065             


Glu Thr  Asn Glu Gly Ala Leu  Tyr Gly Gln Thr Leu  Tyr Pro Ala 
    1070                 1075                 1080             


Pro Lys  Asn Asp Lys Lys Thr  Arg Asn Leu Ile Asn  Ser Lys Lys 
    1085                 1090                 1095             


Asn Arg  Pro Ser Asp Ile Tyr  Gly Gly Tyr Ser Asn  Glu Asn Gly 
    1100                 1105                 1110             


Ser Phe  Leu Thr Leu Val Lys  Leu Lys Lys Gly Ser  Lys Tyr Asp 
    1115                 1120                 1125             


Tyr Arg  Leu Val Ala Val Pro  Val Ser Lys Ile Ser  Glu Ile Lys 
    1130                 1135                 1140             


Glu Ser  Glu Leu Ala Thr Ile  Glu Lys Ala Ile Ala  Pro Gln Phe 
    1145                 1150                 1155             


Leu Lys  Ser Ser Gly Lys Tyr  Arg Asp Phe Gln Val  Val Leu Ser 
    1160                 1165                 1170             


Lys Ile  Leu Ile Asn Gln Lys  Val Ile Asp Asp Gly  Met Ile Phe 
    1175                 1180                 1185             


Thr Ile  Gly Ser Lys Ser Tyr  Lys His Asn Ala Lys  Gln Val Val 
    1190                 1195                 1200             


Leu Ser  Asp Asn Ser Ile Gln  Ile Val Ser Thr Leu  Ser Arg Ile 
    1205                 1210                 1215             


Ser Asp  Lys Glu Lys Leu Ile  Thr Val Phe Asp Glu  Ile Val Asp 
    1220                 1225                 1230             


Ile Thr  Ser Lys Tyr Leu Pro  Trp Tyr Lys Val Asn  Asp Val Glu 
    1235                 1240                 1245             


Lys Thr  Lys Met Leu Phe Arg  Gln Met Gln Asp Ile  Asp Glu Met 
    1250                 1255                 1260             


Lys Lys  Ile Ile Asp Asn Ser  Leu Ile Gly Leu His  Cys Asn Ala 
    1265                 1270                 1275             


Ser Ile  Thr Asp Leu Gly Lys  Val Gly Leu Ser Lys  Tyr Trp Gly 
    1280                 1285                 1290             


Arg Phe  Val Leu Thr Ala Gly  Ile Ser Leu Thr Val  Asp Ala Gln 
    1295                 1300                 1305             


Leu Ile  Tyr Gln Ser Pro Thr  Gly Leu Phe Glu His  Arg Val Lys 
    1310                 1315                 1320             


Val Ser  Asp Leu 
    1325         


<210> 283
<211> 1391
<212> PRT
<213> Lactobacillus gasseri


<220>
<223> Lactobacillus gasseri JV-V03

<400> 283
Met Thr Lys Ile Lys Asn Glu Tyr Ile Val Gly Leu Asp Val Gly Thr 
1               5                   10                  15      


Asn Ser Cys Gly Trp Val Ala Met Asp Phe Gln Asn Thr Ile Leu Arg 
            20                  25                  30          


Met His Gly Lys Thr Ala Ile Gly Ser His Leu Phe Asp Ala Gly Asn 
        35                  40                  45              


Ser Ala Ala Asp Arg Arg Ala Phe Arg Thr Thr Arg Arg Arg Ile Lys 
    50                  55                  60                  


Arg Arg Lys Trp Arg Leu Lys Leu Leu Glu Glu Ile Phe Asp Pro Tyr 
65                  70                  75                  80  


Met Thr Glu Val Asp Pro Tyr Phe Phe Ala Arg Leu Lys Glu Ser Gly 
                85                  90                  95      


Leu Ser Pro Leu Asp Lys Arg Lys Asn Val Ser Ser Ile Val Phe Pro 
            100                 105                 110         


Thr Ala Leu Glu Asp Lys Lys Phe Tyr Cys Asn Tyr Pro Thr Ile Tyr 
        115                 120                 125             


His Leu Arg Tyr Asp Leu Met Ser Glu Asp Lys Lys Phe Asp Leu Arg 
    130                 135                 140                 


Glu Ile Tyr Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe 
145                 150                 155                 160 


Leu Tyr Asn Thr Pro Val Lys Asp Phe Glu Ala Ser Lys Ile Asp Val 
                165                 170                 175     


Lys Asp Ser Leu Glu Lys Leu Asn Glu Leu Tyr Glu Arg Leu Asp Ser 
            180                 185                 190         


Glu Phe Thr Val Glu Leu Asp Ser Ser Asn Ala Leu Glu Ile Glu Lys 
        195                 200                 205             


Ile Ile Arg Asp Lys Lys Val Phe Lys Ile Asn Lys Val Lys Ser Ile 
    210                 215                 220                 


His Gln Leu Leu Ser Leu Lys Thr Glu Asn Lys Glu Arg Thr Lys Leu 
225                 230                 235                 240 


Ile Lys Asp Val Ser Lys Gln Ile Ile Asn Ala Ile Leu Gly Tyr Lys 
                245                 250                 255     


Thr Lys Phe Glu Thr Ile Leu Leu Lys Asn Ile Ser Lys Asp Glu Ala 
            260                 265                 270         


Asp Asp Trp Glu Phe Lys Leu Thr Asp Val Asp Ala Asp Asn Lys Phe 
        275                 280                 285             


Glu Asn Leu Ile Gly Asp Leu Asn Glu Asn Glu Gln Glu Ile Leu Leu 
    290                 295                 300                 


Glu Ile Arg Asn Leu Ala Asn Ala Ile Thr Leu Ser Asn Ile Val Glu 
305                 310                 315                 320 


Glu Gly Lys Thr Leu Ser Glu Ser Met Ile Asp Lys Tyr Asn Lys His 
                325                 330                 335     


Ser Asp Asp Leu Glu Leu Leu Lys Gln Val Ile Ser Asp His Pro Asp 
            340                 345                 350         


Arg Asp Lys Ala Lys Lys Leu Ala Leu Ala Tyr Asp Leu Tyr Val Asn 
        355                 360                 365             


Asn Arg His Gly Lys Leu Leu Gln Ala Lys Asp Val Leu Gly Ser Lys 
    370                 375                 380                 


Lys Thr Leu Ser Lys Glu Asp Phe Tyr Lys Glu Val Lys Lys Asn Leu 
385                 390                 395                 400 


Asp Asp Ser Lys Ala Ser Gln Glu Ile Leu Asp Thr Ile Ala Leu Asp 
                405                 410                 415     


Ser Phe Met Pro Lys Gln Arg Thr Asn Glu Asn Gly Val Ile Pro Tyr 
            420                 425                 430         


Gln Leu His Gln Leu Glu Leu Asp Arg Ile Ile Lys Asn Gln Gly Lys 
        435                 440                 445             


Tyr Tyr Pro Phe Leu Lys Glu Val Asn Pro Val Ser Ser His Leu Lys 
    450                 455                 460                 


Glu Ala Pro Tyr Lys Leu Asp Glu Leu Ile Arg Phe Arg Val Pro Tyr 
465                 470                 475                 480 


Tyr Val Gly Pro Leu Ile Ser Pro Asn Glu Ser Thr Lys Asn Lys Gln 
                485                 490                 495     


Thr Lys Lys Asn Gln Asn Phe Ala Trp Met Ile Arg Lys Glu Gln Gly 
            500                 505                 510         


Gln Ile Thr Pro Trp Asn Phe Asp Gln Lys Val Asp Arg Met Ala Ser 
        515                 520                 525             


Ala Asn Lys Phe Ile Lys Arg Met Thr Thr Lys Asp Thr Tyr Leu Leu 
    530                 535                 540                 


Gly Glu Asp Val Leu Pro Ala Asn Ser Leu Leu Tyr Gln Lys Phe Thr 
545                 550                 555                 560 


Val Leu Asn Glu Leu Asn Asn Ile Lys Ile Asn Gly Lys Arg Ile Ser 
                565                 570                 575     


Val Pro Leu Lys Glu Glu Leu Tyr Asn Asn Leu Phe Lys Lys Asn Ser 
            580                 585                 590         


Thr Val Thr Thr Asn Lys Leu Lys Ser Tyr Leu Lys Glu Asn Tyr Asn 
        595                 600                 605             


Leu Ile Asn Val Glu Ile Lys Gly Leu Ala Asp Glu Lys Lys Phe Asn 
    610                 615                 620                 


Ser Gly Leu Thr Thr Tyr Asn Lys Leu Arg Asn Leu Lys Ile Phe Asp 
625                 630                 635                 640 


Gln Gln Leu Asp Asp Leu Asn Tyr Asp Lys Asp Phe Glu Arg Ile Ile 
                645                 650                 655     


Glu Trp Ser Thr Ile Phe Glu Asp Lys Ala Ile Tyr Lys Asp Lys Leu 
            660                 665                 670         


Lys Thr Ile Lys Trp Leu Ser Asp Arg Gln Ile Asp Lys Leu Ser Lys 
        675                 680                 685             


Ile Arg Met Gln Gly Trp Gly Gln Leu Ser Lys Lys Leu Leu Ser Gln 
    690                 695                 700                 


Leu Thr Asp Asn Asn Gly Gln Thr Ile Ile Glu Gln Leu Trp Asp Ser 
705                 710                 715                 720 


Gln Asn Asn Phe Met Gln Ile Val Asn Gln Ser Asp Phe Lys Asp Ala 
                725                 730                 735     


Ile Ala Val Ala Asn Gln Asn Leu Leu Val Asn Thr Ser Val Glu Asp 
            740                 745                 750         


Ile Leu Asn Glu Ala Tyr Thr Ser Pro Ala Asn Lys Lys Ala Ile Arg 
        755                 760                 765             


Gln Val Val Lys Val Val Asp Asp Ile Val Lys Ala Ala Ser Gly Lys 
    770                 775                 780                 


Val Pro Lys Gln Ile Ala Ile Glu Phe Thr Arg Asp Ala Asp Asp Lys 
785                 790                 795                 800 


Ala Lys Ile Ser Gln Thr Arg Ala Asn Lys Leu Arg Lys Val Tyr Lys 
                805                 810                 815     


Glu Leu Ser Asn Glu Leu Ala Ser Glu Thr Ile Arg Asn Glu Leu Glu 
            820                 825                 830         


Arg Val Ala Lys Asp Gln Lys Leu Leu Lys Asp Lys Tyr Tyr Leu Tyr 
        835                 840                 845             


Phe Met Gln Leu Gly Arg Asp Ala Tyr Thr Gly Glu Pro Ile Asn Ile 
    850                 855                 860                 


Asp Asp Leu Gly Gln Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Phe 
865                 870                 875                 880 


Ile Lys Asp Asp Ser Leu Glu Asn Arg Val Leu Val Lys Lys Ala Val 
                885                 890                 895     


Asn Asn Gly Lys Ser Asp Asn Val Pro Val Lys Leu Tyr Gly Asn Arg 
            900                 905                 910         


Met Ala Ala Asp Leu Gly Met Thr Ile Arg His Met Trp Glu Lys Trp 
        915                 920                 925             


Lys Asp Gln Gly Leu Ile Thr Lys Thr Lys Tyr Asn Asn Leu Ile Ile 
    930                 935                 940                 


Asp Pro Asp Lys Ile Asn Lys Tyr Glu Ser Ser Gly Phe Ile His Arg 
945                 950                 955                 960 


Gln Leu Val Glu Thr Ser Gln Ile Ile Lys Leu Val Ser Thr Ile Leu 
                965                 970                 975     


Gln Ser Lys Tyr Pro Asp Thr Glu Ile Ile Val Val Lys Ala Arg Tyr 
            980                 985                 990         


Asn His Tyr Leu Arg Lys His Leu  Asn Leu Tyr Lys Ser  Arg Glu Val 
        995                 1000                 1005             


Asn Asp  Tyr His His Ala Ile  Asp Ala Tyr Leu Ser  Ala Ile Cys 
    1010                 1015                 1020             


Gly Asn  Leu Leu Tyr Gln Val  Tyr Pro Tyr Leu Arg  Pro Phe Phe 
    1025                 1030                 1035             


Val Tyr  Gly Gln Tyr Lys Lys  Phe Ser Ser Asp Pro  Lys Lys Glu 
    1040                 1045                 1050             


Lys Ile  Ile Tyr Asp Lys Thr  Arg Lys Tyr Asn Phe  Ile Ser Gln 
    1055                 1060                 1065             


Ile Phe  Glu Asn Lys Ser Asn  Asp Ile Ile Ser Leu  Glu Thr Lys 
    1070                 1075                 1080             


Lys Lys  Val Phe Asp Lys Lys  Asp Ile Ile Glu Lys  Leu Lys His 
    1085                 1090                 1095             


Ala Tyr  Asn Tyr Lys Tyr Met  Leu Val Ser Arg Glu  Thr Glu Thr 
    1100                 1105                 1110             


His Asp  Gln Glu Met Phe Lys  Met Thr Val Tyr Pro  Arg Leu Ser 
    1115                 1120                 1125             


Arg Asp  Thr Lys Lys Ser Arg  Asn Leu Ile Ser Lys  Lys Lys Asp 
    1130                 1135                 1140             


Met Pro  Thr Glu Ile Tyr Gly  Gly Tyr Thr Asn Asn  Ser Asp Ala 
    1145                 1150                 1155             


Tyr Met  Val Ile Ala Arg Ile  Asn Lys Lys Lys Gly  Thr Glu Tyr 
    1160                 1165                 1170             


Arg Val  Phe Gly Val Pro Met  Arg Glu Leu Val Asn  Leu Arg Lys 
    1175                 1180                 1185             


Ala Glu  Lys Asn Gly Arg Tyr  Asn Ala Tyr Leu Lys  Gln Val Leu 
    1190                 1195                 1200             


Glu Pro  Glu Ile Met Tyr Ser  Lys Asn Gly Lys Lys  Asn Lys Thr 
    1205                 1210                 1215             


Ile Ser  Ser Phe Glu Ile Val  Lys Ala Lys Val Pro  Tyr Lys Gln 
    1220                 1225                 1230             


Val Ile  Leu Asp Gly Asp Lys  Lys Phe Met Leu Ala  Ser Ser Thr 
    1235                 1240                 1245             


Tyr Val  Gln Asn Ala Lys Gln  Leu Thr Leu Ser Gln  Asn Ser Met 
    1250                 1255                 1260             


Gln Ala  Ile Thr Asp Asn Cys  Glu Asn Asp Thr Glu  Glu Glu Lys 
    1265                 1270                 1275             


Ala Leu  Glu Glu Lys Ala Leu  Ile Glu Ala Tyr Asp  Glu Ile Leu 
    1280                 1285                 1290             


Thr Asn  Ile Asp Lys Tyr Leu  Pro Leu Phe Asp Ile  Asn Lys Phe 
    1295                 1300                 1305             


Arg Glu  Lys Leu His Ala Gly  Arg Glu Lys Phe Ile  Asn Leu Ser 
    1310                 1315                 1320             


Leu Asp  Val Lys Lys Asp Thr  Ile Leu Gln Val Leu  Asn Gly Leu 
    1325                 1330                 1335             


His Asp  Asn Ala Val Met Pro  Lys Ile Lys Ser Leu  Gly Leu Ser 
    1340                 1345                 1350             


Thr Pro  Leu Gly Phe Met Gln  Phe Ser Ser Gly Val  Pro Leu Ser 
    1355                 1360                 1365             


Glu Asn  Ala Lys Leu Ile Tyr  Gln Ser Pro Thr Gly  Leu Phe Glu 
    1370                 1375                 1380             


Lys Arg  Val Lys Ile Ser Asp  Leu 
    1385                 1390     


<210> 284
<211> 1386
<212> PRT
<213> Lactobacillus hominis


<220>
<223> Lactobacillus hominis CRBIP 24.179

<400> 284
Met Thr Lys Ile Thr Glu Asp Tyr Ile Val Gly Leu Asp Ile Gly Thr 
1               5                   10                  15      


Asn Ser Cys Gly Trp Val Ala Met Asp Ser Lys Asn Thr Ile Leu Arg 
            20                  25                  30          


Met His Gly Lys Thr Ala Ile Gly Ser His Leu Phe Asp Ala Gly Asn 
        35                  40                  45              


Ser Ala Ala Asp Arg Arg Ala Phe Arg Thr Thr Arg Arg Arg Ile Lys 
    50                  55                  60                  


Arg Arg Lys Trp Arg Leu Lys Leu Leu Glu Glu Ile Phe Asp Ser His 
65                  70                  75                  80  


Leu Ala Lys Val Asp Pro Tyr Phe Phe Ala Arg Leu Lys Glu Ser Gly 
                85                  90                  95      


Leu Ser Pro Leu Asp Thr Arg Lys Asn Val Ser Ser Ile Ile Tyr Pro 
            100                 105                 110         


Thr Ser Leu Glu Asp Lys Lys Phe Tyr Val Asp Asn Pro Thr Ile Tyr 
        115                 120                 125             


His Leu Arg Tyr Lys Leu Met Thr Glu Asp Arg Lys Phe Asp Leu Arg 
    130                 135                 140                 


Glu Val Tyr Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe 
145                 150                 155                 160 


Leu Tyr Asn Thr Pro Val Lys Ala Phe Glu Ala Ser Lys Ile Asp Val 
                165                 170                 175     


Lys Gly Ser Leu Lys Lys Leu Asn Glu Leu Tyr Glu Gly Leu Asp Ser 
            180                 185                 190         


Glu Phe Asn Val Glu Leu Asp Ser Asn Asn Ala Leu Glu Ile Glu Asn 
        195                 200                 205             


Ile Ile Arg Asp Lys Lys Ile Phe Lys Ile Asn Lys Val Lys Glu Ile 
    210                 215                 220                 


Asn Gln Leu Leu Ser Leu Lys Thr Glu Asp Lys Glu Arg Thr Lys Leu 
225                 230                 235                 240 


Met Lys Asp Val Ser Lys Gln Ile Val Asn Ala Ile Leu Gly Tyr Lys 
                245                 250                 255     


Thr Lys Phe Glu Thr Ile Leu Leu Lys Asp Val Ser Lys Asp Glu Ala 
            260                 265                 270         


Asp Asp Trp Glu Phe Lys Leu Thr Asp Val Asp Ala Asp Asn Lys Phe 
        275                 280                 285             


Glu Asn Leu Ile Gly Asp Leu Asn Glu Asn Glu Gln Glu Ile Leu Leu 
    290                 295                 300                 


Val Ile Arg Lys Leu Ala Asn Ala Ile Thr Leu Ser Asn Ile Val Glu 
305                 310                 315                 320 


Glu Gly Lys Thr Leu Ser Glu Ser Met Lys Asp Lys Tyr Lys Lys His 
                325                 330                 335     


Ser Asp Asp Leu Lys Leu Leu Lys Gln Val Ile Ser Asp His Pro Asp 
            340                 345                 350         


Arg Asp Lys Ala Lys Lys Leu Ala Leu Ala Tyr Asp Leu Tyr Val Asn 
        355                 360                 365             


Asn Arg His Gly Lys Ile Leu Gln Ala Lys Asp Ile Leu Glu Lys Lys 
    370                 375                 380                 


Lys Thr Leu Ser Lys Glu Asp Phe Tyr Lys Glu Ile Lys Lys Asn Leu 
385                 390                 395                 400 


Asp Asp Ser Lys Glu Ser Gln Glu Ile Leu Asp Ala Ile Ser Leu Asp 
                405                 410                 415     


Ser Phe Met Pro Lys Gln Arg Thr Asn Glu Asn Gly Val Ile Pro Tyr 
            420                 425                 430         


Gln Leu His Gln Leu Glu Leu Asp Lys Ile Ile Glu Asn Gln Gly Lys 
        435                 440                 445             


Tyr Tyr Pro Phe Leu Lys Glu Val Asn Pro Val Ser Ser His Leu Lys 
    450                 455                 460                 


Gln Ala Pro Tyr Lys Leu Asp Glu Leu Ile Arg Phe Arg Val Pro Tyr 
465                 470                 475                 480 


Tyr Val Gly Pro Leu Ile Ser Pro Asn Glu Ser Thr Lys Asn Lys Gln 
                485                 490                 495     


Thr Lys Lys Asn Gln Asn Phe Ala Trp Met Ile Arg Lys Glu Gln Gly 
            500                 505                 510         


Gln Ile Thr Pro Trp Asn Phe Asp Gln Lys Val Asp Arg Met Ala Ser 
        515                 520                 525             


Ala Asn Lys Phe Ile Lys Arg Met Thr Thr Ile Asp Thr Tyr Leu Leu 
    530                 535                 540                 


Gly Glu Asp Val Leu Pro Ala Asn Ser Leu Leu Tyr Gln Lys Phe Thr 
545                 550                 555                 560 


Val Leu Asn Glu Leu Asn Asn Val Lys Ile Asn Gly Lys Arg Ile Ser 
                565                 570                 575     


Val Pro Leu Lys Gln Glu Leu Tyr Asn Asn Leu Phe Lys Lys Asn Ser 
            580                 585                 590         


Thr Val Thr Thr Asn Lys Leu Lys Ser Tyr Leu Lys Glu Asn Tyr Lys 
        595                 600                 605             


Leu Ile Lys Val Glu Ile Lys Gly Leu Ser Asp Glu Lys Lys Phe Asn 
    610                 615                 620                 


Ser Gly Leu Thr Thr Tyr Asn Lys Leu Lys Asn Leu Lys Ile Phe Asp 
625                 630                 635                 640 


Gln Gln Ile Asp Asp Pro Asn Tyr Asn Lys Asp Phe Glu Arg Ile Ile 
                645                 650                 655     


Glu Trp Ser Thr Ile Phe Glu Asp Lys Ala Ile Tyr Lys Glu Lys Leu 
            660                 665                 670         


Lys Thr Ile Asp Trp Leu Ser Asp Arg Gln Ile Asp Lys Leu Ser Lys 
        675                 680                 685             


Ile Arg Met Gln Gly Trp Gly Gln Leu Ser Lys Lys Leu Leu Ser Gln 
    690                 695                 700                 


Leu Thr Asp Asn Asn Gly Gln Thr Ile Ile Glu Gln Leu Trp Asp Ser 
705                 710                 715                 720 


Gln Asn Asn Phe Met Gln Ile Val Asn Gln Ala Asp Phe Lys Asp Ala 
                725                 730                 735     


Ile Ala Val Ala Asn Gln Asn Leu Leu Val Asp Thr Ser Val Glu Asp 
            740                 745                 750         


Ile Leu Asn Glu Ala Tyr Thr Ser Pro Ala Asn Lys Lys Ala Ile Arg 
        755                 760                 765             


Gln Val Val Lys Val Val Asp Asp Ile Val Lys Ala Thr Ser Gly Lys 
    770                 775                 780                 


Val Pro Lys Gln Ile Ala Ile Glu Phe Thr Arg Asp Ala Asp Asp Asn 
785                 790                 795                 800 


Ala Lys Ile Ser Gln Ser Arg Ala Asn Lys Leu Arg Lys Val Tyr Lys 
                805                 810                 815     


Glu Met Ser Asn Glu Leu Ala Ser Glu Thr Ile Arg Asn Glu Leu Glu 
            820                 825                 830         


Arg Val Ala Lys Asp Gln Lys Leu Leu Lys Asp Lys His Tyr Leu Tyr 
        835                 840                 845             


Phe Met Gln Leu Gly Arg Asp Ala Tyr Thr Gly Glu Leu Ile Asp Ile 
    850                 855                 860                 


Asp Asn Leu Glu Gln Tyr Asp Ile Asp His Val Leu Pro Gln Ser Phe 
865                 870                 875                 880 


Ile Lys Asp Asp Ser Leu Glu Asn Arg Val Leu Val Lys Lys Ala Val 
                885                 890                 895     


Asn Asn Gly Lys Ser Asp Asn Val Pro Val Lys Leu Tyr Gly Asn Arg 
            900                 905                 910         


Met Ala Thr Asp Leu Gly Met Thr Ile Arg His Met Trp Glu Lys Trp 
        915                 920                 925             


Lys Glu Gln Gly Leu Ile Thr Lys Thr Lys Tyr Asn Asn Leu Ile Ile 
    930                 935                 940                 


Asp Pro Asp Lys Ile Asn Lys Tyr Glu Ser Ser Gly Phe Ile His Arg 
945                 950                 955                 960 


Gln Leu Val Glu Thr Ser Gln Ile Ile Lys Leu Val Ser Thr Ile Leu 
                965                 970                 975     


Gln Ser Lys Tyr Pro Asp Thr Glu Ile Ile Val Val Lys Ala Arg Tyr 
            980                 985                 990         


Asn His Tyr Leu Arg Lys Arg Leu  Asn Leu Tyr Lys Ser  Arg Glu Val 
        995                 1000                 1005             


Asn Asp  Tyr His His Ala Ile  Asp Ala Tyr Leu Ser  Ala Ile Cys 
    1010                 1015                 1020             


Gly Asn  Leu Leu Tyr Gln Val  Tyr Pro Tyr Leu Arg  Pro Phe Phe 
    1025                 1030                 1035             


Val Tyr  Gly Gln Tyr Lys Lys  Phe Ser Ser Glu Pro  Glu Lys Glu 
    1040                 1045                 1050             


Lys Ile  Ile Tyr Asp Lys Thr  Arg Arg Tyr Asn Phe  Ile Ser Gln 
    1055                 1060                 1065             


Ile Phe  Glu Asn Lys Asp Asn  Asp Ile Ile Ser Arg  Glu Thr Lys 
    1070                 1075                 1080             


Lys Lys  Val Phe Asp Lys Lys  Asp Ile Ile Glu Lys  Leu Lys Arg 
    1085                 1090                 1095             


Ala Tyr  Asn Tyr Lys Tyr Met  Leu Val Ser Arg Glu  Thr Glu Thr 
    1100                 1105                 1110             


His Asp  Gln Glu Met Phe Lys  Met Thr Val Tyr Pro  Arg Leu Ser 
    1115                 1120                 1125             


Arg Asp  Thr Lys Lys Ser Arg  Asn Leu Ile Pro Lys  Lys Lys Asp 
    1130                 1135                 1140             


Met Pro  Thr Glu Ile Tyr Gly  Gly Tyr Thr Asn Asn  Ser Asp Ala 
    1145                 1150                 1155             


Tyr Met  Ile Ile Ala Arg Ile  Asn Lys Lys Lys Gly  Pro Glu Tyr 
    1160                 1165                 1170             


Arg Val  Phe Gly Val Pro Met  Arg Glu Leu Val Asn  Leu Arg Lys 
    1175                 1180                 1185             


Ala Glu  Lys Asn Gly His Tyr  Lys Ala Tyr Leu Lys  Gln Val Leu 
    1190                 1195                 1200             


Glu Pro  Glu Ile Met Tyr Ser  Lys Asn Gly Lys Lys  Asn Lys Thr 
    1205                 1210                 1215             


Ile Ser  Ser Phe Glu Ile Val  Lys Ala Lys Val Pro  Tyr Lys Gln 
    1220                 1225                 1230             


Val Ile  Leu Asp Gly Asp Lys  Lys Phe Met Leu Ala  Ser Ser Thr 
    1235                 1240                 1245             


Tyr Val  Gln Asn Ala Lys Gln  Leu Thr Leu Ser Gln  Tyr Ser Met 
    1250                 1255                 1260             


Gln Ala  Ile Thr Asp Asn Cys  Glu Asn Asp Thr Glu  Glu Glu Lys 
    1265                 1270                 1275             


Ala Leu  Val Glu Ala Tyr Asp  Glu Ile Leu Thr Asn  Ile Asp Lys 
    1280                 1285                 1290             


Tyr Leu  Pro Leu Phe Asp Ile  Asn Lys Phe Arg Glu  Lys Leu His 
    1295                 1300                 1305             


Ala Gly  Arg Glu Lys Phe Val  Asp Leu Pro Leu Ala  Glu Lys Lys 
    1310                 1315                 1320             


Glu Thr  Ile Leu Gln Val Leu  Asn Gly Leu His Asp  Asn Ala Val 
    1325                 1330                 1335             


Met Pro  Lys Ile Lys Ser Leu  Gly Leu Ser Thr Pro  Leu Gly Phe 
    1340                 1345                 1350             


Met Gln  Phe His Thr Gly Val  Ser Leu Ser Glu Asn  Ala Lys Leu 
    1355                 1360                 1365             


Ile Tyr  Gln Ser Pro Thr Gly  Leu Phe Glu Lys Arg  Leu Lys Ile 
    1370                 1375                 1380             


Ser Asp  Leu 
    1385     


<210> 285
<211> 1369
<212> PRT
<213> Lactobacillus iners


<220>
<223> Lactobacillus iners LactinV 11V1-d

<400> 285
Met Asn Asn Asn Tyr Tyr Leu Gly Leu Asp Leu Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Thr Asp Asp His Tyr Asn Ile Ile Lys Phe His Gly 
            20                  25                  30          


Lys His Met Trp Gly Met Arg Leu Phe Glu Glu Ala Glu Thr Ala Lys 
        35                  40                  45              


Asp Arg Arg Leu His Arg Gln Ala Arg Arg Arg Arg Gln Arg Leu Val 
    50                  55                  60                  


Glu Arg Ile Asn Leu Leu Glu Glu Leu Phe Asp Lys Glu Ile Ser Lys 
65                  70                  75                  80  


Val Asp Gln Gly Phe Phe Ala Arg Lys Lys Glu Ser Asp Leu His Phe 
                85                  90                  95      


Glu Asp Lys Thr Thr Lys Ser Glu Tyr Ala Leu Phe Asn Asp Lys Ser 
            100                 105                 110         


Tyr Thr Asp Arg Asp Tyr Tyr Lys Gln Tyr Pro Thr Ile Phe His Leu 
        115                 120                 125             


Ile Met Asp Leu Ile Glu Asn Asp Lys Lys Arg Asp Ile Arg Leu Val 
    130                 135                 140                 


Tyr Leu Ala Cys His Tyr Leu Ile Lys His Arg Gly His Phe Ile Phe 
145                 150                 155                 160 


Asp Gly Lys Asn Phe Thr Val Asp Asn Ser Phe Glu Asn Leu Leu Asp 
                165                 170                 175     


Lys Leu Ile Thr Tyr Leu Lys Asp Asn Asp Asp Ile Thr Leu Ser Phe 
            180                 185                 190         


Pro Lys Asp Gln Leu Ile Asn Ile Phe Lys Asn Ser Asn Leu Asn Ser 
        195                 200                 205             


Thr Glu Lys Ser Asp Gln Leu Lys Pro Phe Phe Gly Arg Thr Asn Leu 
    210                 215                 220                 


Glu Lys Gly Ile Ile Lys Leu Leu Ser Gly Gly Lys Gln Asp Leu Ser 
225                 230                 235                 240 


Asn Met Phe Arg Asp Glu Thr Leu Lys Asn Ser Asn Tyr Lys Asn Leu 
                245                 250                 255     


Lys Phe Ser Asp Asn Arg Phe Asp Asp Glu Arg Asp Gly Tyr Ala Ala 
            260                 265                 270         


Asp Leu Gly Asp Arg Ile Asp Leu Leu Ile Leu Leu Lys Gln Ile Tyr 
        275                 280                 285             


Asp Ala Ser Ile Leu Glu Ser Met Met Ser Gln Ala Arg Val Ser Ile 
    290                 295                 300                 


Asp Gly His Lys Tyr Ile Ser Ser Ala Lys Val Cys Ala Tyr Glu Lys 
305                 310                 315                 320 


His Lys Ser Asp Leu Lys Arg Leu Lys Ser Leu Ile Lys Lys Tyr Leu 
                325                 330                 335     


Pro Ser Glu Tyr Asn Asn Ile Phe Arg Lys Ile Thr Glu Lys Asp Asn 
            340                 345                 350         


Tyr Val Ala Tyr Ser Lys Ser Asn Ile Thr Asn Asn Lys Arg Glu Lys 
        355                 360                 365             


Ala Leu Lys Tyr Val Lys Tyr Val Asp Phe Thr Lys Tyr Leu Thr Lys 
    370                 375                 380                 


Lys Leu Lys Thr Ile Lys Thr Gln Asp Ala Glu Asp Asp Gln Glu Ile 
385                 390                 395                 400 


Phe Glu Ile Lys Gly Glu Leu Glu Lys Gln Ser Phe Leu Pro Lys Gln 
                405                 410                 415     


Arg Thr Leu Asp Asn Ser Ile Ile Pro Tyr Gln Leu His Leu Met Glu 
            420                 425                 430         


Leu Lys Lys Ile Leu Asp Asn Gln Ser Lys Tyr Tyr Asp Phe Leu Leu 
        435                 440                 445             


Ala Lys Asp Asp Gln Glu Gly Ile Thr Val Lys Asp Lys Ile Ile Ser 
    450                 455                 460                 


Leu Leu Thr Phe Arg Leu Pro Tyr Tyr Ile Gly Pro Val Asn Pro Ala 
465                 470                 475                 480 


Val His Gly Lys Phe Ala Trp Val Lys Arg Leu Ala Asn Gly Lys Val 
                485                 490                 495     


Thr Pro Trp Asn Tyr Lys Glu Lys Ile Asp Ile Asp Ala Ser His Glu 
            500                 505                 510         


Glu Phe Ile Lys Thr Lys Leu Ser Lys Cys Ser Phe Leu Ile Gly Cys 
        515                 520                 525             


Asp Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Tyr Met Val Leu 
    530                 535                 540                 


Ser Glu Leu Asn Thr Ile Lys Phe Asn Gly Val Asn Ile Ser Glu Lys 
545                 550                 555                 560 


Leu Lys Asp Asp Ile Tyr Gln Asn Leu Phe Lys Asn Ile Gln Lys Val 
                565                 570                 575     


Thr Lys Lys Arg Leu Gln Asn Tyr Ile Lys Glu His Glu Asn Ile Ile 
            580                 585                 590         


Gly Asp Val Ile Val Thr Gly Ile Asp Asn Ala Phe Lys Gln Gly Leu 
        595                 600                 605             


Val Ser Tyr Leu Lys Phe Lys Lys Ile Ile Gly Asp Lys Val Asp Asp 
    610                 615                 620                 


Asp Arg Tyr Gln Lys Val Leu Glu Lys Ile Ile Arg Asp Ile Thr Leu 
625                 630                 635                 640 


Tyr Asp Glu Cys Ala Gly Lys Lys Ile Lys Lys Glu Tyr Lys Asp Ser 
                645                 650                 655     


Asp Leu Phe Thr Glu Asp Glu Leu Asn Lys Ile Val Lys Leu Thr Phe 
            660                 665                 670         


Asn Asp Trp Gly Arg Leu Ser Ala Glu Leu Leu Asp Gln Leu Glu Gly 
        675                 680                 685             


Glu Asp Thr Val Ser Gly Glu Thr Gly Lys Ile Ile Glu Phe Met Gln 
    690                 695                 700                 


Lys His Asn Tyr Asn Leu Met Gln Leu Met Ser Lys Lys Phe Thr Phe 
705                 710                 715                 720 


Lys Ser Lys Ile Asp Glu Ile Asn Lys Ser Tyr Tyr Gln His Asp Lys 
                725                 730                 735     


Phe Asn Tyr Lys Ser Met Ile Asp Ser Leu Tyr Val Ser Pro Ala Thr 
            740                 745                 750         


Lys Arg Ile Leu Trp Gln Ser Leu Lys Val Val His Glu Ile Ser Lys 
        755                 760                 765             


Ile Met Lys His Asp Pro Glu Lys Ile Phe Ile Glu Met Ala Arg Ser 
    770                 775                 780                 


Lys Glu Asp His Pro Lys Arg Lys Leu Ser Arg Lys Ala Asp Leu Lys 
785                 790                 795                 800 


Gln Val Tyr Lys Asp Ser Lys Lys Gln Ile Ile Ser Ile Ile Gly Lys 
                805                 810                 815     


Asp Lys Tyr Gln Asp Leu Ser Asn Glu Leu Asp Asn Lys Asp Asp Arg 
            820                 825                 830         


Asp Leu Arg Trp Asp Asn Leu Tyr Leu Tyr Tyr Thr Gln Leu Gly Arg 
        835                 840                 845             


Ser Met Tyr Ser Leu Lys Pro Ile Asp Ile Ser Glu Leu Met Asn Lys 
    850                 855                 860                 


Asn Leu Tyr Asp Gln Asp His Ile Phe Pro Lys Ser Lys Lys Tyr Asp 
865                 870                 875                 880 


Asp Ser Ile Glu Asn Arg Val Leu Val Glu Lys Glu Leu Asn Val Lys 
                885                 890                 895     


Lys Ser Asp Ile Tyr Pro Ile Ser Asp Ala Asn Ile Ile Pro Gln Lys 
            900                 905                 910         


Ile Lys Gly Gln Val Glu Ser Phe Trp Lys Met Leu Tyr Asp His Lys 
        915                 920                 925             


Leu Ile Gly Asp Lys Lys Tyr Ala Arg Leu Ile Arg Ser Lys Ala Phe 
    930                 935                 940                 


Thr Asp Asp Glu Leu Ala Gly Phe Ile Ala Arg Gln Leu Val Glu Thr 
945                 950                 955                 960 


Arg Gln Ala Thr Lys Glu Thr Ala Asp Leu Leu Lys Arg Leu Cys Pro 
                965                 970                 975     


Lys Ser Arg Ile Val Tyr Ala Lys Ala Gln Asn Ala Ser Ile Phe Arg 
            980                 985                 990         


Gln Lys Phe Asp Ile Pro Lys Ser  Arg Thr Ile Asn Asp  Leu His His 
        995                 1000                 1005             


Ala Gln  Asp Ala Tyr Leu Asn  Ile Val Val Gly Asn  Ile Phe Asp 
    1010                 1015                 1020             


Thr Lys  Phe Thr Gln Asp Pro  Arg Asn Phe Ile Lys  Asn Thr Lys 
    1025                 1030                 1035             


Asp Ser  Arg Asn Tyr Asn Leu  Glu Lys Ile Tyr Asp  Tyr Asn Val 
    1040                 1045                 1050             


Glu Arg  Asn Asn Tyr Val Ala  Trp Ile Ala Pro Asp  Gly Glu Thr 
    1055                 1060                 1065             


Asn Gly  Thr Ile Ala Asn Val  Lys Cys Asn Leu Ser  Thr Lys Asp 
    1070                 1075                 1080             


Phe Arg  Val Thr Arg Pro Ser  Phe Tyr Lys Lys Gly  Ala Leu Phe 
    1085                 1090                 1095             


Asn Gln  Asn Leu Ser Arg Lys  Gly Ser Asn Leu Ala  Pro Ile Lys 
    1100                 1105                 1110             


Glu His  Ser Pro Lys Ser Asn  Pro Leu Lys Tyr Gly  Gly Tyr Ser 
    1115                 1120                 1125             


Gly Lys  Asn Asn Ser Phe Phe  Val Val Val Ala Gly  Lys Asp Asn 
    1130                 1135                 1140             


Lys Gly  Lys Asp Ile Val Lys  Leu Ile Pro Val Asn  Thr Leu Ile 
    1145                 1150                 1155             


Tyr Asn  Lys Met Leu His Cys  Asp Tyr Lys Ala Lys  Gln Glu Leu 
    1160                 1165                 1170             


Leu Thr  Ser Tyr Val Ala Asn  Asn Phe Ala Ile Asn  Asn Phe Arg 
    1175                 1180                 1185             


Ile Val  Lys Asp Asp Ile Lys  Met Tyr Ser Leu Val  Lys Ile Asp 
    1190                 1195                 1200             


Gly Ala  Tyr Tyr Tyr Leu Val  Gly Gly Thr Asp Glu  Arg Ile Glu 
    1205                 1210                 1215             


Val Lys  Asn Ala Met Gln Leu  Leu Leu Ser Lys Asp  Ser Ile Lys 
    1220                 1225                 1230             


Ala Val  Lys Ile Leu Glu Lys  Glu Ser Lys Asp Gln  Phe Ala Asn 
    1235                 1240                 1245             


Ile Lys  Asn Tyr Lys Asp Ile  Asp Ile Lys Leu Gly  Arg Thr Phe 
    1250                 1255                 1260             


Asn Glu  Val Val Ser Lys Tyr  Thr Asn Ser Val Phe  Gly Lys Ser 
    1265                 1270                 1275             


Met Leu  Ile Ser Asp Lys Tyr  Arg Lys Asp Ile Phe  Lys Ser Val 
    1280                 1285                 1290             


Glu Lys  Ser Ile Leu Glu Phe  Asn His Leu Asp Thr  Ile Gly Lys 
    1295                 1300                 1305             


Ala Asp  Asn Leu Leu Lys Phe  Val Thr Leu Met Arg  Pro Ser Gly 
    1310                 1315                 1320             


Ser Ala  His Ser Leu Lys Met  Val Gly Leu Ile Glu  Arg Ile Arg 
    1325                 1330                 1335             


Lys Ser  Asn Val Ile Ser Asn  Phe Asn Glu Phe Lys  Leu Ile Asn 
    1340                 1345                 1350             


Gln Ser  Val Thr Gly Leu Phe  Glu Asn Glu Glu Asp  Leu Leu Lys 
    1355                 1360                 1365             


Leu 
    


<210> 286
<211> 1391
<212> PRT
<213> Lactobacillus jensenii


<220>
<223> Lactobacillus jensenii 269-3

<400> 286
Met Lys Glu Ile Lys Asp Tyr Ile Ile Gly Leu Asp Ile Gly Thr Asn 
1               5                   10                  15      


Ser Cys Gly Tyr Val Val Thr Asp Lys Gln Asn Asn Ile Leu Lys Leu 
            20                  25                  30          


Lys Gly Lys Thr Ala Ile Gly Ala Arg Leu Phe Lys Glu Gly Glu Ala 
        35                  40                  45              


Ala Ala Asp Arg Arg Ala Phe Arg Thr Thr Arg Arg Arg Leu Ala Arg 
    50                  55                  60                  


Arg Arg Trp Arg Leu Ser Leu Leu Glu Glu Ile Phe Asp Glu Glu Met 
65                  70                  75                  80  


Asn Lys Val Asp Pro Ser Phe Phe Arg Arg Leu Lys Glu Ser Asp Tyr 
                85                  90                  95      


Ser Pro Lys Asp Arg Arg Lys Gln Phe Asn Ser Ile Val Phe Glu Ser 
            100                 105                 110         


Ser Glu Ala Asp Lys Ala Phe Tyr Glu Lys Tyr Pro Thr Ile Tyr His 
        115                 120                 125             


Leu Arg Asn Ala Leu Met His Asp Asn Gln Lys His Asp Leu Arg Glu 
    130                 135                 140                 


Ile Phe Leu Ala Val His His Ile Val Lys Tyr Arg Gly Asn Phe Leu 
145                 150                 155                 160 


Arg Glu Asp Ser Val Lys Ala Phe Lys Ala Ala Lys Phe Thr Leu Gln 
                165                 170                 175     


Gly Glu Asp Gly Ile Gly Pro Val Asp Lys Leu Asn Asp Leu Leu Lys 
            180                 185                 190         


Glu Ile Tyr Ile Glu Ala Ala Pro Glu Leu Ala Thr Asp Asn Leu Ser 
        195                 200                 205             


Lys Ile Glu Asp Ile Ile Lys Asp Lys Lys Leu Tyr Lys Gln Asp Lys 
    210                 215                 220                 


Leu Lys Gln Ile Ala Asn Leu Leu Pro Lys Ala Val Asp Ser Lys Asp 
225                 230                 235                 240 


Lys Ala Lys Leu Asn Lys Asp Ile Ala Lys Gln Val Ala Asn Ala Leu 
                245                 250                 255     


Met Gly Tyr Met Phe Arg Leu Asp Thr Leu Phe Ser Phe Thr Asp Val 
            260                 265                 270         


Asp Val Lys Asp Tyr Lys Leu Lys Phe Ser Asp Ala Asn Ile Asp Glu 
        275                 280                 285             


Ser Leu Asp Ala Leu Thr Ser Leu Leu Thr Asp Ala Gln Ile Glu Phe 
    290                 295                 300                 


Val Leu Glu Leu Gln Ser Ile Tyr Asn Thr Ile Val Leu Asn Glu Ile 
305                 310                 315                 320 


Val Pro Asp Gly Met Ser Leu Ser Glu Ser Met Val Lys Lys Tyr Asp 
                325                 330                 335     


Asp His Lys Lys Asp Leu Lys Leu Tyr Lys Glu Tyr Ile Asp Ser Leu 
            340                 345                 350         


Ser Asp Gln Lys Lys Ala Lys Gln Leu Glu Ala Ala Tyr Ala Leu Tyr 
        355                 360                 365             


Val Asn Tyr Arg Lys Ala Asp Leu Leu Ala Ala Lys Lys Leu Phe Glu 
    370                 375                 380                 


Lys Lys Lys Ile Gly Asp Lys Lys Phe Val Asp Val Ile Ser Asn Phe 
385                 390                 395                 400 


Glu Val Phe Gly Lys Phe Val Ser Asp Asn Leu Asp Asp Ser Glu Leu 
                405                 410                 415     


Ala Asn Lys Ile Lys Ala Arg Leu Asp Leu Gly Glu Phe Leu Pro Lys 
            420                 425                 430         


Gln Arg Thr Asn Gln Asn Gly Val Ile Pro Tyr Gln Leu His Gln Val 
        435                 440                 445             


Glu Leu Thr Gln Ile Leu Glu Lys Gln Gly Lys Tyr Tyr Pro Phe Leu 
    450                 455                 460                 


Ile Thr Pro Asn Pro Val Glu Ser His Arg Asn Asn Ala Pro Tyr Glu 
465                 470                 475                 480 


Ile Ser Glu Leu Val Ser Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu 
                485                 490                 495     


Ile Asp Asn Gln Ser Ile Lys Asp Lys Gln Asn Lys Asn Lys Phe Ala 
            500                 505                 510         


Trp Met Val Arg Gln Lys Gln Gly Gln Ile Thr Pro Trp Asn Phe Glu 
        515                 520                 525             


Glu Met Val Asp Thr Thr Glu Ser Ala Asn Gln Phe Ile Lys Arg Met 
    530                 535                 540                 


Thr Arg Lys Asp Thr Tyr Leu Leu Ala Glu Asp Val Leu Pro Lys Ser 
545                 550                 555                 560 


Ser Leu Ile Tyr Gln Lys Phe Met Ile Leu Asp Glu Leu Asn Arg Ile 
                565                 570                 575     


Lys Ile Asp Gly Lys Lys Leu Thr Ser Lys Leu Lys His Asp Ile Phe 
            580                 585                 590         


Glu Lys Leu Phe Lys Lys Gln Lys Ser Ile Asn Leu Asp Asn Leu Lys 
        595                 600                 605             


Asn Tyr Leu Leu Ala Glu Gly Asn Ile Pro Gly Leu Ile Glu Gly Leu 
    610                 615                 620                 


Ser Asp Gly Ile Asn Phe Asn Asn Ser Phe Ser Thr Tyr Ile Asp Tyr 
625                 630                 635                 640 


Arg Asn Ile Phe Gly Asp Glu Ile Asp Asn Pro Asn Lys Gln Ala Asp 
                645                 650                 655     


Phe Glu Lys Met Ile Glu Trp Ser Thr Val Phe Glu Asp Arg Lys Ile 
            660                 665                 670         


Phe Lys Arg Lys Leu Lys Glu Ile Thr Trp Leu Thr Pro Glu Gln Ile 
        675                 680                 685             


Lys Gln Val Ser Ser Lys Arg Tyr Ser Gly Trp Gly Arg Leu Ser Lys 
    690                 695                 700                 


Lys Leu Leu Thr Gln Ile Thr Asp Glu Asn Gly Val Asn Ile Leu Gln 
705                 710                 715                 720 


Arg Leu Trp Asn Glu Pro Glu Thr Leu Thr Glu Val Leu Ala Asn Pro 
                725                 730                 735     


Val Ile Lys Arg Lys Ile Ser Glu Ala Asn Ser Leu Phe Val Gln Ile 
            740                 745                 750         


Asn Lys Val Glu Asn Ile Leu Asp Asp Ala Tyr Thr Ser Pro Gln Asn 
        755                 760                 765             


Lys Lys Ala Ile Arg Gln Val Ile Arg Val Val Asp Asp Ile Ile Ala 
    770                 775                 780                 


Ala Ala His Gly Lys Lys Pro Ser Gln Ile Ala Ile Glu Phe Ala Arg 
785                 790                 795                 800 


Ser Ser Gln Asn Lys Ala Lys Val Pro Asp Thr Arg Lys Lys Gln Leu 
                805                 810                 815     


Asp Lys Ile Tyr Asn Lys Ile Ser Ser Glu Ile Leu Asp Ser Ser Ile 
            820                 825                 830         


Lys Asn Glu Leu Lys Asn Leu Lys Ser Asn Lys Tyr Leu Ser Lys Asp 
        835                 840                 845             


Lys Leu Phe Leu Tyr Phe Lys Gln Met Gly Arg Asp Ala Tyr Thr Gly 
    850                 855                 860                 


Asp Lys Leu Ser Leu Asp Gln Leu Gln Asn Tyr Asp Ile Asp His Ile 
865                 870                 875                 880 


Phe Pro Arg Ser Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu 
                885                 890                 895     


Thr Gln Lys Pro Ile Asn Ala Lys Lys Ser Asp Tyr Gly Ile Pro Ala 
            900                 905                 910         


Leu Glu Phe Gly Asn Lys Tyr Val Pro Asp Leu Gly Ile Thr Val Lys 
        915                 920                 925             


Glu Met Trp Lys Leu Trp Gln Glu Asn Gly Leu Ile Ser Lys Ser Lys 
    930                 935                 940                 


Leu Ile Asn Leu Cys Thr Asn Pro Lys Lys Ile Gly Ser Lys Arg Ala 
945                 950                 955                 960 


Ser Gly Phe Ile Asn Arg Gln Leu Val Glu Thr Ser Gln Val Ile Lys 
                965                 970                 975     


Leu Val Ala Ile Ile Leu Gln Ala Glu Phe Pro Asp Thr Glu Ile Ile 
            980                 985                 990         


Glu Val Lys Ala Leu Gln Asn Thr  Thr Leu Arg Glu Ser  Phe His Leu 
        995                 1000                 1005             


Tyr Lys  Asn Arg Ser Val Asn  Asp Tyr His His Ala  Ile Asp Ala 
    1010                 1015                 1020             


Tyr Leu  Thr Thr Ile Val Gly  Asn Tyr Leu Tyr Gln  Val Tyr Pro 
    1025                 1030                 1035             


Lys Leu  Arg Pro Tyr Phe Val  Tyr Gly Gln Phe Lys  Lys Phe Asn 
    1040                 1045                 1050             


Gln Glu  Lys Asn Ile Asp Ile  Leu Lys Arg Leu Lys  Asn Phe Asn 
    1055                 1060                 1065             


Phe Leu  Arg Gln Leu Ile Phe  Asn Thr Asp Asp Asn  Ile Tyr Ile 
    1070                 1075                 1080             


Ser Gly  Thr Lys Glu Ile Val  Phe Asn Lys Lys Asp  Ile Ile His 
    1085                 1090                 1095             


Lys Leu  Glu Thr Ala Tyr Gly  Tyr Lys Tyr Met Asn  Ile Ser Arg 
    1100                 1105                 1110             


Glu Cys  Tyr Gln Glu Thr Ser  Ser Leu Phe Asn Gln  Thr Leu Tyr 
    1115                 1120                 1125             


Ala His  Asn Ser Ser Val Lys  Asn Ser Leu Ile Pro  Lys Lys Lys 
    1130                 1135                 1140             


Gly Leu  Pro Thr Glu Ile Tyr  Gly Gly Tyr Ser Gly  Asn Lys Asp 
    1145                 1150                 1155             


Ser Phe  Phe Val Leu Val Lys  Ile Val Lys Lys Arg  Thr Asn Leu 
    1160                 1165                 1170             


Tyr Arg  Ile Val Gly Ile Pro  Thr Arg Glu Leu Ala  Lys Leu Asn 
    1175                 1180                 1185             


Ser Ser  Asn Asn Tyr Asn Gln  Ala Leu Asn Lys Ile  Val Glu Ser 
    1190                 1195                 1200             


Lys Leu  Cys Leu Lys Glu Thr  Glu Ser Phe Lys Ile  Leu Ile Lys 
    1205                 1210                 1215             


Arg Leu  Leu Tyr Gly Thr Leu  Ile Val Asp Asn Gly  Gln Lys Phe 
    1220                 1225                 1230             


Arg Ile  Gly Ser Phe Lys Glu  Lys His Asn Val Gln  Gln Leu Val 
    1235                 1240                 1245             


Leu Gln  Leu Lys Ser Met Lys  Tyr Ile Lys Phe Tyr  Ile Asp Gly 
    1250                 1255                 1260             


Gly Gln  Asn Tyr Phe Thr Asp  Val Glu Arg Lys Lys  Leu Glu Lys 
    1265                 1270                 1275             


Gln Asp  Arg Asp Lys Cys Leu  Leu Tyr Val Phe Asp  Asp Ile Met 
    1280                 1285                 1290             


Asn Val  Val Asn Lys Arg Phe  Thr Leu Phe Asp Met  Ser Lys Tyr 
    1295                 1300                 1305             


Glu Lys  Asp Gly Asp Ser Leu  Arg Glu Lys Phe Asn  Cys Leu Asp 
    1310                 1315                 1320             


Phe Asn  Asp Lys Val Ser Ile  Leu Ser Asp Leu Leu  Lys Ala Phe 
    1325                 1330                 1335             


His Ala  Asn Ser Asp Arg Thr  Ser Ile Thr Lys Leu  Lys Ile Thr 
    1340                 1345                 1350             


Asn Leu  Gly Arg His Gln Ala  Gly Lys Asn Gly Ile  Thr Leu Thr 
    1355                 1360                 1365             


Thr Asn  Ala Gln Ile Ile Tyr  Gln Ser Pro Thr Gly  Leu Phe Glu 
    1370                 1375                 1380             


Arg Arg  Ile Lys Ile Lys Asp  Leu 
    1385                 1390     


<210> 287
<211> 1395
<212> PRT
<213> Lactobacillus jensenii


<220>
<223> Lactobacillus jensenii 27-2-CHN

<400> 287
Met Lys Glu Ile Lys Asp Tyr Ile Ile Gly Leu Asp Ile Gly Thr Asn 
1               5                   10                  15      


Ser Cys Gly Tyr Val Val Thr Asp Lys Gln Asn Asn Ile Leu Lys Leu 
            20                  25                  30          


Lys Gly Lys Thr Ala Ile Gly Ala Arg Leu Phe Lys Glu Gly Gln Ala 
        35                  40                  45              


Ala Ala Asp Arg Arg Ser Phe Arg Thr Thr Arg Arg Arg Leu Ala Arg 
    50                  55                  60                  


Arg His Trp Arg Leu Gly Leu Leu Glu Glu Ile Phe Asp Pro Glu Met 
65                  70                  75                  80  


Glu Lys Ile Asp Pro Asn Phe Phe Arg Arg Leu Lys Glu Ser Asp Tyr 
                85                  90                  95      


Ser Pro Lys Asp Ser Arg Lys Gln Phe Asn Ala Ile Val Phe Lys Ser 
            100                 105                 110         


Ile Lys Ala Asp Lys Arg Phe Tyr Lys Lys Tyr Pro Thr Ile Tyr His 
        115                 120                 125             


Leu Arg Asn Ala Leu Met His Asp Asn Gln Lys His Asp Leu Arg Glu 
    130                 135                 140                 


Ile Phe Met Ala Val His His Ile Val Lys Tyr Arg Gly Asn Phe Leu 
145                 150                 155                 160 


Arg Glu Asp Ser Val Asn Ala Phe Lys Ala Ala Lys Phe Ser Leu Arg 
                165                 170                 175     


Gly Glu Asp Gly Ile Gly Pro Val Asp Lys Leu Asn Asp Leu Leu Lys 
            180                 185                 190         


Glu Ile Tyr Ser Glu Tyr Ser Pro Glu Leu Ala Thr Asn Asn Leu Ser 
        195                 200                 205             


Lys Ile Glu Asp Ile Ile Lys Asp Lys Asn Leu Tyr Lys Gln Asp Lys 
    210                 215                 220                 


Leu Lys Gln Val Ala Thr Leu Leu Ile Lys Glu Ala Asp Ser Lys Asp 
225                 230                 235                 240 


Lys Ala Lys Leu Asn Lys Asp Ile Ala Lys Gln Val Ala Asn Ser Phe 
                245                 250                 255     


Met Gly Tyr Met Phe Arg Leu Asp Thr Leu Phe Ser Leu Thr Asp Val 
            260                 265                 270         


Asp Val Lys Asp Tyr Lys Leu Lys Phe Ser Asp Ala Asn Ile Asp Glu 
        275                 280                 285             


Ser Leu Asp Asp Leu Thr Ser Leu Leu Thr Asp Ala Gln Ile Glu Phe 
    290                 295                 300                 


Val Leu Glu Leu Gln Ser Ile Tyr Asn Thr Ile Val Leu Asn Glu Ile 
305                 310                 315                 320 


Val Pro Asp Gly Met Ser Leu Ser Glu Ser Met Ile Lys Lys Tyr Asp 
                325                 330                 335     


Asp His Lys Glu Asp Leu Lys Ile Phe Lys Glu Tyr Ile Asp Ser Leu 
            340                 345                 350         


Ser Asp Gln Lys Lys Ala Lys Lys Leu Leu Ser Ala Tyr Asn Leu Tyr 
        355                 360                 365             


Val Asn Tyr Arg Lys Ser Asp Leu Val Glu Ala Lys Asn Leu Phe Lys 
    370                 375                 380                 


Asn Lys Lys Val Gly Asp Lys Asn Phe Ala Asp Val Ile Ser Asn Phe 
385                 390                 395                 400 


Glu Val Phe Gly Lys Phe Val Ser Asp Asn Leu Asp Asp Ser Glu Leu 
                405                 410                 415     


Ala Asn Lys Ile Lys Ala Arg Leu Asp Leu Gly Glu Phe Leu Pro Lys 
            420                 425                 430         


Gln Arg Thr Asn Gln Asn Gly Val Ile Pro Tyr Gln Leu His Gln Val 
        435                 440                 445             


Glu Leu Thr Gln Ile Leu Glu Lys Gln Gly Lys Tyr Tyr Pro Phe Leu 
    450                 455                 460                 


Ile Thr Pro Asn Pro Val Glu Ser His Arg Asn Asn Ala Pro Tyr Glu 
465                 470                 475                 480 


Ile Ser Glu Leu Val Ser Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu 
                485                 490                 495     


Ile Asp Asn Gln Ser Ile Lys Asp Lys Gln Asn Lys Asn Lys Phe Ala 
            500                 505                 510         


Trp Met Val Arg Gln Lys Gln Gly Gln Ile Thr Pro Trp Asn Leu Glu 
        515                 520                 525             


Glu Met Val Asp Thr Thr Glu Ser Ala Asn Gln Phe Ile Lys Arg Met 
    530                 535                 540                 


Thr Arg Lys Asp Thr Tyr Leu Leu Ala Glu Asp Val Leu Pro Lys Ser 
545                 550                 555                 560 


Ser Leu Val Tyr Gln Lys Phe Met Ile Leu Asp Glu Leu Asn Arg Ile 
                565                 570                 575     


Lys Ile Asp Gly Lys Lys Leu Thr Ser Glu Leu Lys His Asp Ile Phe 
            580                 585                 590         


Glu Lys Leu Phe Lys Lys Gln Lys Ser Ile Asn Leu Asp Asn Leu Lys 
        595                 600                 605             


Asn Tyr Leu Leu Val Glu Gly Asn Ile Pro Gly Leu Ile Glu Gly Leu 
    610                 615                 620                 


Ser Asp Gly Ile Asn Phe Asn Asn Ser Phe Ser Thr Tyr Ile Asp Tyr 
625                 630                 635                 640 


Arg Asn Ile Phe Gly Asp Glu Ile Asp Asn Pro Asn Lys Gln Ala Asp 
                645                 650                 655     


Phe Glu Lys Met Ile Glu Trp Ser Thr Val Phe Glu Asp Arg Lys Ile 
            660                 665                 670         


Phe Lys Arg Lys Leu Lys Glu Ile Thr Trp Leu Thr Ser Glu Gln Ile 
        675                 680                 685             


Lys Gln Val Ser Ser Lys Arg Tyr Ser Gly Trp Gly Arg Leu Ser Lys 
    690                 695                 700                 


Lys Leu Leu Thr Gln Ile Thr Asp Glu Asn Gly Val Asn Ile Leu Gln 
705                 710                 715                 720 


Arg Leu Trp Asn Glu Pro Glu Thr Leu Thr Glu Val Leu Ala Asn Pro 
                725                 730                 735     


Val Ile Lys Arg Lys Ile Val Glu Ala Asn Ser Ser Phe Thr Lys Ala 
            740                 745                 750         


Lys Asp Met Lys Asp Ile Leu Val Glu Ala Tyr Thr Ser Pro Gln Asn 
        755                 760                 765             


Lys Lys Ala Ile Arg Gln Val Met Arg Val Val Asp Asp Ile Ile Ala 
    770                 775                 780                 


Ala Ala His Gly Lys Lys Pro Ser Gln Ile Ala Ile Glu Phe Ala Arg 
785                 790                 795                 800 


Glu Asp Gln Asp Asn Pro Gln Met Thr Lys Ser Arg Lys Ala Gln Leu 
                805                 810                 815     


Asp Gln Ile Tyr Ala Lys Ile Ser Asp Glu Phe Leu Asp Asp Ala Val 
            820                 825                 830         


Lys Asn Glu Leu Lys Asn Met Lys Asp Asn Lys Pro Leu Ala Lys Asp 
        835                 840                 845             


Lys Val Phe Leu Tyr Phe Lys Gln Met Gly Arg Asp Ala Tyr Ser Gly 
    850                 855                 860                 


Glu Lys Leu Ser Leu Asp Asn Leu Gln Asp Tyr Asp Ile Asp His Ile 
865                 870                 875                 880 


Tyr Pro Gln Ser Phe Ile Lys Asp Asp Ser Phe Asp Asn Arg Val Leu 
                885                 890                 895     


Val Gln Arg Ala Tyr Asn Asn Gly Lys Ser Asp Asn Val Pro Val Leu 
            900                 905                 910         


Leu Phe Gly Asn Lys Ile Ala Ala Gly Leu Gly Ile Thr Ile Arg Gln 
        915                 920                 925             


Met Trp Lys Lys Trp Leu Glu Leu Gly Leu Ile Ser Lys Arg Lys Phe 
    930                 935                 940                 


Asn Asn Leu Ile Thr Asp Pro Glu Lys Ile Ser Arg Asn Met Ala Ser 
945                 950                 955                 960 


Gly Phe Val Asn Arg Gln Leu Val Glu Thr Ser Gln Val Ile Lys Leu 
                965                 970                 975     


Val Ala Asn Ile Leu Gln Ala Lys Leu Pro Asp Thr Glu Ile Ile Glu 
            980                 985                 990         


Val Lys Ala Ser Tyr Asn Ser Ile  Leu Arg Lys Glu Phe  Asn Leu Tyr 
        995                 1000                 1005             


Lys Ser  Arg Glu Val Asn Asp  Tyr His His Ala Ile  Asp Ala Tyr 
    1010                 1015                 1020             


Leu Thr  Thr Ile Val Gly Asn  Tyr Leu Tyr Gln Val  Tyr Pro Lys 
    1025                 1030                 1035             


Leu Arg  Pro Tyr Phe Val Tyr  Gly Gln Phe Lys Lys  Phe Gly Lys 
    1040                 1045                 1050             


Ala Glu  Asn Gln Glu Asp Asp  Pro Val Lys Lys Ile  Lys Lys Phe 
    1055                 1060                 1065             


Asn Phe  Ile Tyr Gln Leu Ile  Trp Gly Lys Asp Asp  Ala Ile Cys 
    1070                 1075                 1080             


Ile Ser  His Thr Asn Gln Gln  Val Phe Ser Lys Lys  Asp Ile Ile 
    1085                 1090                 1095             


Asp Lys  Leu Thr Thr Ala Tyr  Asn Phe Lys Tyr Met  Asn Ile Ser 
    1100                 1105                 1110             


His Ala  Val Tyr Thr Arg Asn  Asn Asn Met Phe Lys  Gln Thr Leu 
    1115                 1120                 1125             


Phe Pro  Ile Ile Glu Arg Thr  Thr Ala Lys Thr Lys  Ser Leu Ile 
    1130                 1135                 1140             


Pro Lys  Lys Leu Asp Arg Pro  Thr Asp Ile Tyr Gly  Gly Tyr Ser 
    1145                 1150                 1155             


Asn Asn  Asn Asp Ala Tyr Leu  Ala Leu Val Lys Val  Asp Lys Lys 
    1160                 1165                 1170             


Arg Gly  Ser Glu Tyr Arg Val  Val Gly Ile Pro Met  Arg Ala Ala 
    1175                 1180                 1185             


Ala Met  Leu Lys Ala Ser Lys  Asn Tyr Asp Glu Asp  Leu Arg Lys 
    1190                 1195                 1200             


Val Ile  Glu Pro Met Val Met  Phe Asp Lys Asn Gly  Lys Ala Lys 
    1205                 1210                 1215             


Arg Gly  Ile Glu Gly Phe Arg  Val Leu Val Gly Lys  Met Pro Phe 
    1220                 1225                 1230             


Lys Gln  Ala Val Leu Asp Gly  Asn Lys Lys Phe Met  Leu Thr Gly 
    1235                 1240                 1245             


Thr Val  Asp Thr Pro Asn Leu  Lys Gln Leu Val Leu  Ser Gln Gln 
    1250                 1255                 1260             


Asn Met  Lys Tyr Ile Leu Asp  Tyr Ile Glu Asp Val  Asp Cys Arg 
    1265                 1270                 1275             


Lys His  Lys Phe Gly Asp Lys  Val Gln Asn Pro Asp  Lys Cys Leu 
    1280                 1285                 1290             


Leu Glu  Val Phe Asp Glu Ile  Ile Glu Ile Val Asp  Lys Tyr Phe 
    1295                 1300                 1305             


Glu Leu  Phe Asp Ser Arg Asp  Phe Arg Glu Lys Leu  Arg Asn Ser 
    1310                 1315                 1320             


Arg Asn  Lys Phe Ile Lys Leu  Glu Ala Ser Lys Lys  Ala Asp Thr 
    1325                 1330                 1335             


Ile Leu  Ala Ile Leu Lys Gly  Leu Gln Ala Lys Ser  Thr Arg Ala 
    1340                 1345                 1350             


Thr Ile  Lys Glu Leu Asn Ile  Ser Asp Phe Gly Arg  Ile Ile Thr 
    1355                 1360                 1365             


Ser Ser  Ile Ser Pro Glu Ala  Gln Leu Ile Tyr Gln  Ser Pro Thr 
    1370                 1375                 1380             


Gly Leu  Phe Glu Arg Arg Val  Lys Val Lys Asp Leu  
    1385                 1390                 1395 


<210> 288
<211> 1375
<212> PRT
<213> Lactobacillus johnsonii

<400> 288
Met Thr Lys Ile Lys Asp Asp Tyr Ile Val Gly Leu Asp Ile Gly Thr 
1               5                   10                  15      


Asp Ser Cys Gly Trp Val Ala Met Asn Ser Asn Asn Asp Ile Leu Lys 
            20                  25                  30          


Leu Gln Gly Lys Thr Ala Ile Gly Ser Arg Leu Phe Glu Gly Gly Lys 
        35                  40                  45              


Ser Ala Ala Glu Arg Arg Leu Phe Arg Thr Thr His Arg Arg Ile Lys 
    50                  55                  60                  


Arg Arg Arg Trp Arg Leu Lys Leu Leu Glu Glu Phe Phe Asp Pro Tyr 
65                  70                  75                  80  


Met Ala Glu Val Asp Pro Tyr Phe Phe Ala Arg Leu Lys Glu Ser Gly 
                85                  90                  95      


Leu Ser Pro Leu Asp Lys Arg Lys Thr Val Ser Ser Ile Val Phe Pro 
            100                 105                 110         


Thr Ser Ala Glu Asp Lys Lys Phe Tyr Asp Asp Tyr Pro Thr Ile Tyr 
        115                 120                 125             


His Leu Arg Tyr Lys Leu Met Thr Glu Asp Glu Lys Phe Asp Leu Arg 
    130                 135                 140                 


Glu Val Tyr Leu Ala Ile His His Ile Ile Lys Tyr Arg Gly Asn Phe 
145                 150                 155                 160 


Leu Tyr Asn Thr Ser Val Lys Asp Phe Lys Ala Ser Lys Ile Asp Val 
                165                 170                 175     


Lys Ser Ser Ile Glu Lys Leu Asn Glu Leu Tyr Glu Asn Leu Gly Leu 
            180                 185                 190         


Asp Leu Asn Val Glu Phe Asn Ile Ser Asn Thr Ala Glu Ile Glu Lys 
        195                 200                 205             


Val Leu Lys Asp Lys Gln Ile Phe Lys Arg Asp Lys Val Lys Lys Ile 
    210                 215                 220                 


Ala Glu Leu Phe Ala Ile Lys Thr Asp Asn Lys Glu Gln Ser Lys Arg 
225                 230                 235                 240 


Ile Lys Asp Ile Ser Lys Gln Val Ala Asn Ala Val Leu Gly Tyr Lys 
                245                 250                 255     


Thr Arg Phe Asp Thr Ile Ala Leu Lys Glu Ile Ser Lys Asp Glu Leu 
            260                 265                 270         


Ser Asp Trp Asn Phe Lys Leu Ser Asp Ile Asp Ala Asp Ser Lys Phe 
        275                 280                 285             


Glu Ala Leu Met Gly Asn Leu Asp Glu Asn Glu Gln Ala Ile Leu Leu 
    290                 295                 300                 


Thr Ile Lys Glu Leu Phe Asn Glu Val Thr Leu Asn Gly Ile Val Glu 
305                 310                 315                 320 


Asp Gly Asn Thr Leu Ser Glu Ser Met Ile Asn Lys Tyr Asn Asp His 
                325                 330                 335     


Arg Asp Asp Leu Lys Leu Leu Lys Glu Val Ile Glu Asn His Ile Asp 
            340                 345                 350         


Arg Lys Lys Ala Lys Glu Leu Ala Leu Ala Tyr Asp Leu Tyr Val Asn 
        355                 360                 365             


Asn Arg His Gly Gln Leu Leu Gln Ala Lys Lys Lys Leu Gly Lys Ile 
    370                 375                 380                 


Lys Pro Arg Ser Lys Glu Asp Phe Tyr Lys Val Val Asn Lys Asn Leu 
385                 390                 395                 400 


Asp Asp Ser Arg Ala Ser Lys Glu Ile Lys Lys Lys Ile Glu Leu Asp 
                405                 410                 415     


Ser Phe Met Pro Lys Gln Arg Thr Asn Ala Asn Gly Val Ile Pro Tyr 
            420                 425                 430         


Gln Leu Gln Gln Leu Glu Leu Asp Lys Ile Ile Glu Asn Gln Ser Lys 
        435                 440                 445             


Tyr Tyr Pro Phe Leu Lys Glu Ile Asn Pro Val Ser Ser His Leu Lys 
    450                 455                 460                 


Glu Ala Pro Tyr Lys Leu Asp Glu Leu Ile Arg Phe Arg Val Pro Tyr 
465                 470                 475                 480 


Tyr Val Gly Pro Leu Ile Ser Pro Asn Glu Ser Thr Lys Asp Ile Gln 
                485                 490                 495     


Thr Lys Lys Asn Gln Asn Phe Ala Trp Met Ile Arg Lys Glu Glu Gly 
            500                 505                 510         


Arg Ile Thr Pro Trp Asn Phe Asp Gln Lys Val Asp Arg Ile Glu Ser 
        515                 520                 525             


Ala Asn Lys Phe Ile Lys Arg Met Thr Thr Lys Asp Thr Tyr Leu Phe 
    530                 535                 540                 


Gly Glu Asp Val Leu Pro Ala Asn Ser Leu Leu Tyr Gln Lys Phe Thr 
545                 550                 555                 560 


Val Leu Asn Glu Leu Asn Asn Ile Arg Ile Asn Gly Lys Arg Ile Ser 
                565                 570                 575     


Val Asp Leu Lys Gln Glu Ile Tyr Glu Asn Leu Phe Lys Lys His Thr 
            580                 585                 590         


Thr Val Thr Val Lys Lys Leu Glu Asn Tyr Leu Lys Glu Asn His Asn 
        595                 600                 605             


Leu Val Lys Val Glu Ile Lys Gly Leu Ala Asp Glu Lys Lys Phe Asn 
    610                 615                 620                 


Ser Gly Leu Thr Thr Tyr Asn Arg Phe Lys Asn Leu Asn Ile Phe Asp 
625                 630                 635                 640 


Asn Gln Ile Asp Asp Leu Lys Tyr Arg Asn Asp Phe Glu Lys Ile Ile 
                645                 650                 655     


Glu Trp Ser Thr Ile Phe Glu Asp Lys Ser Ile Tyr Lys Glu Lys Leu 
            660                 665                 670         


Arg Ser Ile Asp Trp Leu Asn Glu Lys Gln Ile Asn Ala Leu Ser Asn 
        675                 680                 685             


Ile Arg Leu Gln Gly Trp Gly Arg Leu Ser Lys Lys Leu Leu Ala Gln 
    690                 695                 700                 


Leu His Asp His Asn Gly Gln Thr Ile Ile Glu Gln Leu Trp Asp Ser 
705                 710                 715                 720 


Gln Asn Asn Phe Met Gln Ile Val Thr Gln Ala Asp Phe Lys Asp Ala 
                725                 730                 735     


Ile Ala Lys Ala Asn Gln Asn Leu Leu Val Ala Thr Ser Val Glu Asp 
            740                 745                 750         


Ile Leu Asn Asn Ala Tyr Thr Ser Pro Ala Asn Lys Lys Ala Ile Arg 
        755                 760                 765             


Gln Val Ile Lys Val Val Asp Asp Ile Val Lys Ala Ala Ser Gly Lys 
    770                 775                 780                 


Val Pro Lys Gln Ile Ala Ile Glu Phe Thr Arg Asp Ala Asp Glu Asn 
785                 790                 795                 800 


Pro Lys Arg Ser Gln Thr Arg Gly Ser Lys Leu Gln Lys Val Tyr Lys 
                805                 810                 815     


Asp Leu Ser Thr Glu Leu Ala Ser Lys Thr Ile Ala Glu Glu Leu Asn 
            820                 825                 830         


Glu Ala Ile Lys Asp Lys Lys Leu Val Gln Asp Lys Tyr Tyr Leu Tyr 
        835                 840                 845             


Phe Met Gln Leu Gly Arg Asp Ala Tyr Thr Gly Glu Pro Ile Asn Ile 
    850                 855                 860                 


Asp Glu Ile Gln Lys Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Phe 
865                 870                 875                 880 


Ile Lys Asp Asp Ala Leu Asp Asn Arg Val Leu Val Ser Arg Ala Val 
                885                 890                 895     


Asn Asn Gly Lys Ser Asp Asn Val Pro Val Lys Leu Phe Gly Asn Glu 
            900                 905                 910         


Met Ala Ala Asn Leu Gly Met Thr Ile Arg Lys Met Trp Glu Glu Trp 
        915                 920                 925             


Lys Asn Ile Gly Leu Ile Ser Lys Thr Lys Tyr Asn Asn Leu Leu Thr 
    930                 935                 940                 


Asp Pro Asp His Ile Asn Lys Tyr Lys Ser Ala Gly Phe Ile Arg Arg 
945                 950                 955                 960 


Gln Leu Val Glu Thr Ser Gln Ile Ile Lys Leu Val Ser Thr Ile Leu 
                965                 970                 975     


Gln Ser Arg Tyr Pro Asn Thr Glu Ile Ile Thr Val Lys Ala Lys Tyr 
            980                 985                 990         


Asn His Tyr Leu Arg Glu Lys Phe  Asp Leu Tyr Lys Ser  Arg Glu Val 
        995                 1000                 1005             


Asn Asp  Tyr His His Ala Ile  Asp Ala Tyr Leu Ser  Ala Ile Cys 
    1010                 1015                 1020             


Gly Asn  Leu Leu Tyr Gln Asn  Tyr Pro Asn Leu Arg  Pro Phe Phe 
    1025                 1030                 1035             


Val Tyr  Gly Gln Tyr Lys Lys  Phe Ser Ser Asp Pro  Asp Lys Glu 
    1040                 1045                 1050             


Lys Ala  Ile Phe Asn Lys Thr  Arg Lys Phe Ser Phe  Ile Ser Gln 
    1055                 1060                 1065             


Leu Leu  Lys Asn Lys Ser Glu  Asn Ser Lys Glu Ile  Ala Lys Lys 
    1070                 1075                 1080             


Leu Lys  Arg Ala Tyr Gln Phe  Lys Tyr Met Leu Val  Ser Arg Glu 
    1085                 1090                 1095             


Thr Glu  Thr Arg Asp Gln Glu  Met Phe Lys Met Thr  Val Tyr Pro 
    1100                 1105                 1110             


Arg Phe  Ser His Asp Thr Val  Lys Ala Pro Arg Asn  Leu Ile Pro 
    1115                 1120                 1125             


Lys Lys  Met Gly Met Ser Pro  Asp Ile Tyr Gly Gly  Tyr Thr Asn 
    1130                 1135                 1140             


Asn Ser  Asp Ala Tyr Met Val  Ile Val Arg Ile Asp  Lys Lys Lys 
    1145                 1150                 1155             


Gly Thr  Glu Tyr Lys Ile Leu  Gly Ile Pro Thr Arg  Glu Leu Val 
    1160                 1165                 1170             


Asn Leu  Lys Lys Ala Glu Lys  Glu Asp His Tyr Lys  Ser Tyr Leu 
    1175                 1180                 1185             


Lys Glu  Ile Leu Thr Pro Arg  Ile Leu Tyr Asn Lys  Asn Gly Lys 
    1190                 1195                 1200             


Arg Asp  Lys Lys Ile Thr Ser  Phe Glu Ile Val Lys  Ser Lys Ile 
    1205                 1210                 1215             


Pro Tyr  Lys Gln Val Ile Gln  Asp Gly Asp Lys Lys  Phe Met Leu 
    1220                 1225                 1230             


Gly Ser  Ser Thr Tyr Val Tyr  Asn Ala Lys Gln Leu  Thr Leu Ser 
    1235                 1240                 1245             


Thr Glu  Ser Met Lys Ala Ile  Thr Asn Asn Phe Asp  Lys Asp Ser 
    1250                 1255                 1260             


Asp Glu  Asn Asp Ala Leu Ile  Lys Ala Tyr Asp Glu  Ile Leu Asp 
    1265                 1270                 1275             


Lys Val  Asp Lys Tyr Leu Pro  Leu Phe Asp Ile Asn  Lys Phe Arg 
    1280                 1285                 1290             


Glu Lys  Leu His Ser Gly Arg  Glu Lys Phe Ile Lys  Leu Ser Leu 
    1295                 1300                 1305             


Glu Asp  Lys Lys Asp Thr Ile  Leu Lys Val Leu Glu  Gly Leu His 
    1310                 1315                 1320             


Asp Asn  Ala Val Met Thr Lys  Ile Pro Thr Ile Gly  Leu Ser Thr 
    1325                 1330                 1335             


Pro Leu  Gly Phe Met Gln Phe  Pro Asn Gly Val Ile  Leu Ser Glu 
    1340                 1345                 1350             


Asn Ala  Lys Leu Ile Tyr Gln  Ser Pro Thr Gly Leu  Phe Lys Lys 
    1355                 1360                 1365             


Ser Val  Lys Ile Ser Asp Leu  
    1370                 1375 


<210> 289
<211> 1382
<212> PRT
<213> Lactobacillus mucosae


<220>
<223> Lactobacillus mucosae LM1

<400> 289
Met Asp Ile Gly Thr Asn Ser Ile Gly Trp Thr Ala Ile Asp Asp His 
1               5                   10                  15      


Phe Ser Leu Leu Arg Val Lys Gly Lys Asn Ala Ile Gly Val Arg Thr 
            20                  25                  30          


Phe Lys Glu Gly Glu Thr Ala Ala Asp Arg Arg Gly Phe Arg Thr Ala 
        35                  40                  45              


Arg Arg Arg Leu Ser Arg Arg Arg Trp Arg Leu Gln Phe Leu Asp Glu 
    50                  55                  60                  


Phe Phe Ala Pro Tyr Leu Ala Glu Val Asp Pro Asn Phe Leu Ala Arg 
65                  70                  75                  80  


Leu Lys Gln Ser Asp Ile Ser Ala Lys Asp Pro Ala Lys Asn Gln Glu 
                85                  90                  95      


Tyr Met Gly Lys Leu Leu Phe Pro Asp Gln Glu Ala Ala Ser Asp Gly 
            100                 105                 110         


Asn Gly Tyr Pro Thr Leu Ile Gln Met Arg Lys Ala Met Pro Ala Glu 
        115                 120                 125             


Lys Ala Ala Asp Phe Pro Val Phe Asn Ile Tyr Gln Leu Arg Tyr Ala 
    130                 135                 140                 


Leu Met Asn Glu Lys Arg Lys Phe Asp Leu Arg Glu Ile Tyr Leu Ala 
145                 150                 155                 160 


Val His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Asn Asn Thr Ser 
                165                 170                 175     


Val Asp Lys Phe Lys Ala Asp Gln Ile Asp Phe Asn Lys Ser Phe Glu 
            180                 185                 190         


Thr Leu Asn Asp Leu Phe Arg Gln Val Gln Pro Ile Ala Pro Phe Gln 
        195                 200                 205             


Ile Asp Leu Thr Lys Val Asp Glu Leu Gly Lys Leu Leu Leu Asp Thr 
    210                 215                 220                 


Lys Gln Lys Lys Leu Asp Arg Gln Lys Ala Val Ala Lys Leu Leu Pro 
225                 230                 235                 240 


Leu Ile Glu Asp Gly Thr Asp Lys Glu Ile Val Lys Ala His Gln Gln 
                245                 250                 255     


Thr Ala Arg Glu Ile Ser Lys Leu Ile Leu Gly Tyr Lys Ala Lys Val 
            260                 265                 270         


Gly Leu Ile Leu Gln Asn Asn Leu Asp Gln Thr Leu Asp Met Ser Thr 
        275                 280                 285             


Glu Asn Ser Asp Asp Gln Leu Met Gln Ile Ala Glu Glu Leu Asp Asp 
    290                 295                 300                 


Tyr Gln Met Glu Leu Ile Asn Gln Leu Ser Leu Leu Tyr Ser Gln Ile 
305                 310                 315                 320 


Met Leu Asn Glu Ile Val Pro Asn Gly Glu Thr Val Ser Ala Ser Met 
                325                 330                 335     


Leu Asn Arg Tyr Tyr Lys His Arg Cys Gln Leu Lys Glu Leu Lys Asp 
            340                 345                 350         


Tyr Gly Ala Ala Gln Asp Lys Lys Thr Arg Glu Gln Leu Asp His Leu 
        355                 360                 365             


Tyr Ala Glu Tyr Ile Gly Gln Ile Pro Lys Asp Ser Lys Phe Asp Phe 
    370                 375                 380                 


Thr Lys Asp Leu Lys Lys Leu Met Asp Lys Ser Asp Leu Gly Gln Lys 
385                 390                 395                 400 


Ile Lys Asp Glu Ile Glu Ala Gly Asp Tyr Leu Pro Lys Gln Arg Thr 
                405                 410                 415     


Ser Ala Asn Gly Val Ile Pro His Gln Met His Gln Gln Glu Leu Asp 
            420                 425                 430         


Gln Ile Ile Glu Asn Gln Lys Glu Tyr Tyr Pro Trp Leu Ala Glu Pro 
        435                 440                 445             


Asn Pro Val Glu Lys Asn Ile Lys Asn Ala Lys Tyr Lys Leu Asp Gln 
    450                 455                 460                 


Leu Val Ser Phe Arg Val Pro Tyr Tyr Val Gly Pro Met Ile Thr Leu 
465                 470                 475                 480 


Ala Asp Gln Gln Lys Thr Ser Lys Ala Ser Phe Ala Trp Ala Val Arg 
                485                 490                 495     


Lys Lys Ala Gly Lys Ile Thr Pro Trp Asn Phe Tyr Asp Met Ile Asp 
            500                 505                 510         


Arg Glu Lys Ser Ala Asn Asn Phe Ile Lys Arg Met Thr Asn Lys Asp 
        515                 520                 525             


Thr Tyr Leu Leu Ser Glu Asp Val Leu Pro Ala Ser Ser Leu Leu Tyr 
    530                 535                 540                 


Gln Lys Phe Thr Val Leu Asn Glu Leu Asn Asn Ile Arg Val Asn Gly 
545                 550                 555                 560 


Arg Lys Leu Gln Pro Ala Leu Lys Gln Ala Ile Tyr Thr Asp Leu Phe 
                565                 570                 575     


Gln Lys Arg Lys Thr Val Asn Leu Lys Thr Leu Thr Asn Phe Leu Ala 
            580                 585                 590         


Ile His Glu Pro Thr Leu Thr Lys Pro Lys Ile Glu Gly Leu Ser Asn 
        595                 600                 605             


Gly Arg Ser Phe Asn Ser Ser Leu Gly Thr Tyr Ile Asp Met Ser Lys 
    610                 615                 620                 


Ile Leu Gly Asp Ser Leu Asp Asp Leu Asn Tyr Arg Asp Asp Ile Glu 
625                 630                 635                 640 


Lys Ile Ile Glu Trp Ser Thr Val Phe Glu Asp Ser Glu Ile Tyr Gly 
                645                 650                 655     


Val Lys Leu Gln Glu Ile Gln Trp Leu Thr Asn Glu Gln Arg Glu Lys 
            660                 665                 670         


Leu Val Arg Lys Arg Tyr Gln Gly Trp Gly Arg Leu Ser Lys Lys Leu 
        675                 680                 685             


Leu Thr Gly Ile Thr Asp Glu Asn Gly Gln Arg Ile Ile Asp Leu Met 
    690                 695                 700                 


Trp Asp Thr Ser Lys Asn Phe Met Gln Ile Val His Gln Pro Val Phe 
705                 710                 715                 720 


Glu Glu Gln Ile Ala Glu Leu Asn Gln Gln Leu Leu Gln Asp Ala Asp 
                725                 730                 735     


Lys Ala Pro Leu Glu Val Val Asp Asp Ile Leu Ala Asp Ala Tyr Thr 
            740                 745                 750         


Ser Pro Gln Asn Lys Lys Ala Ile Arg Gln Val Val Lys Val Val Ala 
        755                 760                 765             


Asp Val Val Lys Ala Val Gly Asn Ala Pro Ala Ser Ile Ser Ile Glu 
    770                 775                 780                 


Phe Ala Arg Asn Glu Asp Arg Asn Lys Glu Leu Lys Asn Ser Arg Arg 
785                 790                 795                 800 


His Ser Ile Glu Lys Leu Tyr His Glu Thr Ala Glu Lys Leu Val Lys 
                805                 810                 815     


Gln Thr Asn Leu Leu Glu Glu Leu Gly Asn Val Lys Asp Leu Asn Asp 
            820                 825                 830         


Arg Tyr Tyr Leu Tyr Phe Thr Gln Ala Gly Arg Asp Met Tyr Asp Gly 
        835                 840                 845             


Thr Pro Ile Asn Ile Asp Glu Ile Ser Thr His Tyr Glu Ile Asp His 
    850                 855                 860                 


Ile Leu Pro Gln Ser Phe Leu Lys Asp Asn Ser Leu Asp Asn Arg Val 
865                 870                 875                 880 


Leu Val Lys Lys Ser Glu Asn Ala Ala Lys Ser Asp Arg Val Pro Ala 
                885                 890                 895     


Lys Leu Tyr Gly Ala Lys Met Arg Ala Phe Trp Lys Gln Leu Lys Glu 
            900                 905                 910         


Ser Gln Leu Ile Ser Asn Arg Lys Tyr Leu Asn Leu Thr Thr Asp Pro 
        915                 920                 925             


Glu Gln Val Asp Lys Tyr Gln Met Gln Gly Phe Val His Arg Gln Leu 
    930                 935                 940                 


Val Glu Thr Arg Gln Ile Ile Lys Leu Ala Ala Asn Ile Phe Gly Ser 
945                 950                 955                 960 


Leu Tyr Pro Asp Ser Ala Val Ile Glu Thr Arg Ala Glu Leu Thr Lys 
                965                 970                 975     


Gln Leu Arg Glu Lys Phe Ser Leu Tyr Lys Val Arg Asp Val Asn Asp 
            980                 985                 990         


Tyr His His Ala Val Asp Ala Tyr  Leu Thr Ala Phe Ala  Gly His Tyr 
        995                 1000                 1005             


Leu Tyr  Gln Arg Tyr Pro Lys  Leu Arg Pro Met Phe  Val Tyr Gly 
    1010                 1015                 1020             


Asp Tyr  Ala Lys Ile Tyr Ala  Asp Asp Leu Lys Arg  Leu Arg Ser 
    1025                 1030                 1035             


Val Asn  Leu Phe His Asp Leu  Glu Lys Asp Gln Tyr  Asn Ser Gly 
    1040                 1045                 1050             


Thr Ala  Val Asn Pro Glu Thr  Lys Glu Lys Ile Val  Asp Val Asp 
    1055                 1060                 1065             


Trp Leu  Ser Asp Tyr Val Ser  Lys Ile Gln His Phe  Lys Tyr Met 
    1070                 1075                 1080             


Leu Ile  Ser Lys Ala Val Tyr  Thr Gln His Gly Gln  Leu Tyr Gly 
    1085                 1090                 1095             


Ala Thr  Ile Leu Pro Val Ala  Gln Val Asp Lys Ile  Ser Ala Pro 
    1100                 1105                 1110             


Ile Gly  Ile Lys Asp Asp Lys  Pro Val Asp Ile Tyr  Gly Ala Tyr 
    1115                 1120                 1125             


Thr Asn  Glu Val Ala Ala Tyr  Met Ala Ile Val Arg  Val Asn Gly 
    1130                 1135                 1140             


Lys Lys  Pro Lys Tyr Lys Val  Val Ser Val Pro Val  Arg Met Leu 
    1145                 1150                 1155             


Gln Arg  Leu Lys Met Ala Glu  Gln Lys Gly His Asp  Gln Tyr Met 
    1160                 1165                 1170             


Gln Thr  Leu His Asp Val Leu  Leu Arg Asn Phe Thr  Ser Leu Lys 
    1175                 1180                 1185             


Lys Asn  Arg Lys Thr Gly Leu  Lys Glu Ala Val Val  Lys Asp Phe 
    1190                 1195                 1200             


Asp Val  Leu Val Pro Cys Val  Arg Tyr Asn Gln Leu  Val Ile Asp 
    1205                 1210                 1215             


Gly Asp  Thr Lys Phe Thr Leu  Gly Ser Ala Thr Tyr  Gln His Asn 
    1220                 1225                 1230             


Ala Lys  Gln Leu Val Leu Cys  Asn His Ser Leu Glu  Thr Leu Ala 
    1235                 1240                 1245             


Asn Asn  Phe Glu Tyr Val Arg  Lys His Pro Asp Glu  Ala Asp Glu 
    1250                 1255                 1260             


Arg Met  Ile Met Leu Tyr Asp  Asp Ile Leu Asp Gln  Val Asn His 
    1265                 1270                 1275             


Tyr Phe  Thr Leu Tyr Asp Lys  Asn Lys Phe Arg Glu  Lys Leu Asn 
    1280                 1285                 1290             


Ala Gly  Arg Asp Lys Tyr Leu  Lys Leu Pro Thr Phe  Ser Gln Phe 
    1295                 1300                 1305             


Glu Asn  Asn Lys Lys Thr Ala  Ile Gly Lys Ser Glu  Ala Ile Ile 
    1310                 1315                 1320             


Asn Ile  Leu Arg Gly Leu His  Ala Asn Ala Ala Ile  Thr Asn Leu 
    1325                 1330                 1335             


Lys Cys  Leu Gly Val Ser Thr  Pro Phe Gly Gln Leu  Gln Ser Pro 
    1340                 1345                 1350             


Ser Gly  Ile Glu Leu Ser Glu  Asn Ala Lys Leu Val  Tyr Gln Ser 
    1355                 1360                 1365             


Pro Thr  Gly Leu Phe Ser Arg  Glu Val Leu Leu Lys  Asp Leu 
    1370                 1375                 1380         


<210> 290
<211> 1362
<212> PRT
<213> Lactobacillus paracasei


<220>
<223> Lactobacillus paracasei subsp. paracasei 8700:2

<400> 290
Met Thr Lys Leu Gly Lys Pro Tyr Gly Ile Gly Val Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg 
            20                  25                  30          


Leu Lys Gly Lys Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys 
        35                  40                  45              


Ala Ala Ala Lys Arg Arg Ala Gly Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Asn Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Glu Ser His 
65                  70                  75                  80  


Ile Thr Pro Thr Asp Pro Asn Phe Phe Met Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Ala Arg Tyr Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Gln Gln Tyr Ser Thr Met Tyr 
        115                 120                 125             


His Leu Arg Asn Arg Leu Met Thr Asp Pro Ser Arg Ala Asp Val Arg 
    130                 135                 140                 


Glu Ile Tyr Phe Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Pro Gly Asp Ala Lys Asp Phe Asn Thr Asn Asp Val Ala Leu 
                165                 170                 175     


Asp Glu Ile Phe Pro Ala Leu Gln Asp Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Gly Ile Thr Phe Asp Glu Asp Lys Ala Asn Glu Phe Lys Thr 
        195                 200                 205             


Ile Leu Leu Asn Glu Ile Ala Thr Ser Ile Asp Thr Gln Arg Ala Leu 
    210                 215                 220                 


Val Lys Leu Leu Leu Ala Glu Glu Asp Asp Lys Asp Ile Leu Lys Gln 
225                 230                 235                 240 


Gln Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 
                245                 250                 255     


Thr Lys Leu Asn Leu Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 
            260                 265                 270         


Thr Ala Trp Asn Phe Ser Leu Gly Gln Leu Asp Asp Lys Trp Ala Gly 
        275                 280                 285             


Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gln Ile 
    290                 295                 300                 


Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Thr Gly 
305                 310                 315                 320 


Lys Thr Leu Ser Gln Ala Lys Val Asp Asp Tyr Thr Gln His His Glu 
                325                 330                 335     


Asp Leu Gln Leu Phe Lys Ala Tyr Leu Lys Gln Leu Glu Asp Asp Gly 
            340                 345                 350         


Thr Ala Lys Ala Ile Arg Gln Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 
        355                 360                 365             


Asp Ala Ala Pro Phe Leu Arg Glu Asn Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Asp Val Thr Ala His Pro Asn Thr Lys Ser Pro Glu Leu Leu Glu Arg 
385                 390                 395                 400 


Leu Ala Gln Pro Asp Phe Met Leu Lys Gln Arg Asn Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Val Gln Met Gln Gln Arg Glu Leu Asp Gln Ile Ile Lys 
            420                 425                 430         


Asn Gln Ala Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 
        435                 440                 445             


Lys His Arg Lys Ser Met Pro Tyr Gln Leu Asp Glu Leu Leu Asn Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gln Lys 
465                 470                 475                 480 


Ala Ala Gln Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Glu 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 
            500                 505                 510         


Ser Ala Asn Thr Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Arg Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asn Glu Lys Leu 
545                 550                 555                 560 


Ser Ile Glu Gln Lys Gln Gln Val Ile Arg Glu Leu Phe Glu Arg His 
                565                 570                 575     


Asn Ser Val Thr Ile Lys Gln Phe Ala Glu Asn Leu Arg Ala His Gly 
            580                 585                 590         


Asp Tyr Ala His Ile Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr Arg Gln Leu Lys Ser Leu Leu Pro 
    610                 615                 620                 


Glu Ala Ile Asp Asp Pro Ala Lys Gln Ala Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Ala Trp Ser Thr Val Phe Glu Asp Ala Ala Ile Phe Lys Thr Lys Leu 
                645                 650                 655     


Lys Glu Ile Ser Trp Leu Gly Ser Glu Ala Ile Thr Lys Leu Ser Asn 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser Arg Lys Phe Leu Asn Gly 
        675                 680                 685             


Leu Thr Leu Gly Asn Gly His Thr Ile Ile Gln Glu Leu Leu Leu Ser 
    690                 695                 700                 


Thr Asn Asn Leu Met Gln Ile Leu Thr Asp Glu Thr Leu Gln Lys Lys 
705                 710                 715                 720 


Met Thr Glu Leu Asn Ala Asp Lys Leu Lys Thr Ala Asn Ile Asn Asp 
                725                 730                 735     


Ala Ile Asp Asn Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Arg Val Val Asp Asp Ile Lys Arg Ala Ala Asp Gly Gln 
        755                 760                 765             


Asp Pro Ser Trp Leu Tyr Val Glu Thr Ala Asp Gly Gly Gly Thr Pro 
    770                 775                 780                 


Gly Lys Arg Thr Arg Ala Arg Gln His Gln Leu Gln Glu Ile Tyr Ala 
785                 790                 795                 800 


Asn Ala Ala His Glu Leu Ile Asp Thr Ala Val Arg Gly Glu Leu Glu 
                805                 810                 815     


Asp Lys Ile Ser Asp Lys Ala Asp Phe Asn Asp Arg Leu Val Leu Tyr 
            820                 825                 830         


Phe Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Ala Pro Leu Asn Ile 
        835                 840                 845             


Asp Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu 
    850                 855                 860                 


Ile Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val His Ala Ile Ile 
865                 870                 875                 880 


Asn Arg Glu Lys Asn Ala Thr Phe Ala Ser Thr Ile Tyr Ala Gln Lys 
                885                 890                 895     


Met Asn Ala Thr Trp Arg Gln Trp His Glu Ala Gly Leu Ile Ser Gly 
            900                 905                 910         


Arg Lys Leu Arg Asn Leu Gln Met Arg Pro Asp Gln Ile Asp Lys Tyr 
        915                 920                 925             


Ala Ser Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile 
    930                 935                 940                 


Lys Leu Thr Glu Gln Ile Val Ala Ala Gln Tyr Pro Asp Thr Lys Ile 
945                 950                 955                 960 


Ile Ala Val Lys Ala Gly Leu Ser His Gln Leu Arg Glu Glu Leu Glu 
                965                 970                 975     


Phe Pro Lys Asn Arg Asp Val Asn His Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Phe Leu Ala Ala Arg Ile Gly Thr  Tyr Leu Leu Lys Arg  Phe Pro Asn 
        995                 1000                 1005             


Leu Gln  Ala Phe Phe Thr Tyr  Gly Lys Phe Thr Lys  Ala Asp Val 
    1010                 1015                 1020             


Lys Lys  Leu Arg Gly Phe Asn  Phe Ile Arg Asp Ile  Thr His Ala 
    1025                 1030                 1035             


Glu Asp  Lys Ile Val Ala Lys  Asp Thr Gly Glu Val  Val Trp Asp 
    1040                 1045                 1050             


Lys Gln  Arg Asp Val Asp Glu  Leu Asp Arg Ile Tyr  Asn Phe Lys 
    1055                 1060                 1065             


Arg Met  Leu Ile Thr His Glu  Val Arg Phe Glu Thr  Ala Asp Leu 
    1070                 1075                 1080             


Phe Lys  Gln Thr Val Tyr Gly  Ala Arg Asp Ser Lys  Glu Ala Gly 
    1085                 1090                 1095             


Gly Ser  Lys Gln Leu Ile Pro  Lys Lys Lys Gly Tyr  Pro Val Asp 
    1100                 1105                 1110             


Ile Tyr  Gly Gly Tyr Phe Arg  Glu Asn Thr Ala Tyr  Leu Ala Val 
    1115                 1120                 1125             


Val Lys  Val Thr Lys Lys Thr  Glu Thr Ile Phe Lys  Val Val Lys 
    1130                 1135                 1140             


Ile Ala  Thr Ser Gln Val Ala  Ala Leu Asn Lys Ala  Arg Ser Arg 
    1145                 1150                 1155             


Ser Thr  Ala Glu Glu Leu Ser  Val Leu Thr Glu Leu  Leu Lys Pro 
    1160                 1165                 1170             


Lys Phe  Ser Lys Val Gly Lys  Asn Gly Lys Ile Thr  Asp Thr Pro 
    1175                 1180                 1185             


Phe Glu  Val Val Leu Pro Arg  Val Pro Arg Glu Gln  Leu Phe Tyr 
    1190                 1195                 1200             


Asn Ala  Lys Tyr Gly Phe Phe  Met Val Asn Ser Asp  Thr Met Phe 
    1205                 1210                 1215             


His Asn  Phe Gln Glu Ile Trp  Val Ser Arg Ser Asp  Gln Lys Ile 
    1220                 1225                 1230             


Leu Gln  Gln Ile Arg Lys Ala  Lys Ile Asp Tyr Pro  Asn Val Asp 
    1235                 1240                 1245             


Gln Asp  Leu Asp Asn Leu Phe  His Asn Leu Ala Asp  Gln Ile Val 
    1250                 1255                 1260             


Lys Tyr  Phe Asp Leu Tyr Ser  Ile Ala Gly Phe Lys  Glu Lys Ile 
    1265                 1270                 1275             


Ser Gln  Ser Gln Asn Thr Phe  Asn Asp Leu Ala Val  Asp Asp Thr 
    1280                 1285                 1290             


Asp Gln  Ser Val Gly Lys Ile  Thr Val Ile Asn Glu  Leu Leu Lys 
    1295                 1300                 1305             


Gly Ala  Gln Ala Asn Gly Met  Thr Gly Ser Leu Lys  Val Leu Lys 
    1310                 1315                 1320             


Ile Ser  Thr Pro Phe Gly Phe  Thr Gln Asp Lys Ser  Gly Val Leu 
    1325                 1330                 1335             


Thr Lys  Asp Ser Ser Ile Ile  Tyr Gln Ser Pro Thr  Gly Leu Phe 
    1340                 1345                 1350             


Glu Arg  Ser Val Arg Leu Thr  Asp Leu 
    1355                 1360         


<210> 291
<211> 1382
<212> PRT
<213> Lactobacillus pentosus


<220>
<223> Lactobacillus pentosus IG1

<400> 291
Met Lys Lys Ile Val Asn Tyr Asn Leu Gly Leu Asp Ile Gly Thr Ser 
1               5                   10                  15      


Ser Ile Gly Tyr Ala Ala Ile Asp Asp Gln Gly Arg Pro Val Arg His 
            20                  25                  30          


Gln Asn Lys Thr Val Met Gly Val Arg Leu Phe Lys Glu Gly Lys Thr 
        35                  40                  45              


Ala Glu Ser Thr Arg Ile Phe Arg Gly Thr Arg Arg Arg Leu Ser His 
    50                  55                  60                  


Arg His Trp Arg Leu Gly Tyr Leu Asp Arg Ile Phe Asp Asn Glu Ile 
65                  70                  75                  80  


Ala Lys Val Asp Glu Asn Phe Leu Pro Arg Leu Lys Ala Ser Lys Arg 
                85                  90                  95      


Ala Arg Ser Asp Glu Lys Arg Ser Phe Arg Gly Ser Leu Leu Phe Pro 
            100                 105                 110         


Glu Thr Gly Asp Asp Ala Tyr Tyr Gln Lys Tyr Pro Thr Ile Tyr His 
        115                 120                 125             


Leu Arg Tyr Ala Leu Ile Thr Gln Lys Lys Gln Phe Asp Ile Arg Leu 
    130                 135                 140                 


Ile Tyr Leu Ala Leu His His Met Ile Lys Tyr Arg Gly Asn Phe Leu 
145                 150                 155                 160 


Asp Thr Thr Pro Val Ser Ala Phe Asn Ile His Asp Ile Asp Leu Thr 
                165                 170                 175     


Asp Gln Phe Ala Ser Leu Asn Asp Cys Tyr Gln Leu Leu Asp Met Asp 
            180                 185                 190         


Phe Glu Phe Gln Phe Asp Leu Asn Asn Ile Glu Gln Val Gln Lys Leu 
        195                 200                 205             


Leu Leu Asp Glu Thr Leu Ser Lys Thr Lys Arg Gln Ala Ala Val Ser 
    210                 215                 220                 


Lys Val Leu Val Met Ser Thr Gly Asn Lys Ala Phe Asp Asp Gln Gln 
225                 230                 235                 240 


Asn Gly Ile Ala Ser Glu Phe Ile Lys Ala Leu Leu Gly Gly Pro Phe 
                245                 250                 255     


Asp Leu Ser Lys Ile Leu Asn Leu Ser Val Ala Asp Val Lys Ser Trp 
            260                 265                 270         


Lys Leu His Met Thr Asp Lys Asp Val Asp Asp Thr Leu Asn Ser Leu 
        275                 280                 285             


Val Glu Glu Leu Asp Glu Asn His Lys Gln Ile Val Asn Leu Leu Gln 
    290                 295                 300                 


Met Ile Tyr Ser Gln Val Met Met Leu Gly Leu Leu Asn Gly Gln Gln 
305                 310                 315                 320 


Ser Ile Ser Ala Ser Met Ile Glu Arg Tyr Asp Asp His Ala Lys His 
                325                 330                 335     


Trp Ala Ala Leu Lys Lys Leu Leu Pro Ala Leu Gly Glu Gln Glu Gln 
            340                 345                 350         


Ser Thr Ile Ile His Ala Tyr Thr Ala Tyr Thr Gly His Ser Arg Thr 
        355                 360                 365             


Lys Gln Leu Ser Arg Ala Glu Phe Tyr Thr Lys Val Asn Ser Ile Leu 
    370                 375                 380                 


Lys Lys His Glu Asn Ile Ala Glu Ala Thr Gly Leu Ile Glu Leu Ile 
385                 390                 395                 400 


Asp Arg Asn Glu Phe Met Pro Lys Gln Arg Asp Ala Val Asn Gly Val 
                405                 410                 415     


Ile Pro His Gln Leu His Gln Arg Glu Leu Gln Leu Ile Ile Gln Asn 
            420                 425                 430         


Gln Gln Lys Tyr Tyr Pro Phe Leu Ala Ala Lys Ala Tyr Pro Asp Ala 
        435                 440                 445             


Asp Glu Thr Met Ile Glu Gln Leu Leu Ser Phe Arg Val Pro Tyr Tyr 
    450                 455                 460                 


Ala Gly Pro Leu Val Asp Arg Asp Phe Ile Asn Glu Ser Ser Asp Gln 
465                 470                 475                 480 


Glu Gln Ala Met Gln Asn Thr Lys Phe Ser Trp Leu Lys Arg Arg Glu 
                485                 490                 495     


Ala Gly Glu Ile Thr Pro Trp Asn Phe Glu Gln Lys Val Asp Val Gln 
            500                 505                 510         


Glu Thr Ala Asn Arg Phe Ile Lys Arg Leu Thr Thr Lys Asp Thr Tyr 
        515                 520                 525             


Leu Met Thr Glu Asp Val Leu Pro Lys Glu Ser Leu Ile Tyr Gln Arg 
    530                 535                 540                 


Phe Glu Val Leu Asn Glu Leu Asn Ala Ile Arg Ile Asn Asp Arg Arg 
545                 550                 555                 560 


Leu Thr Ala Glu Asn Lys Gln Leu Ala Phe Gln Gln Leu Phe Met Ala 
                565                 570                 575     


Gly Asn Thr Lys Asn Val Ser Ile Lys Lys Phe Arg Asn Phe Val Phe 
            580                 585                 590         


Asp Ser Leu Lys Phe Pro Glu Lys Val Lys Ile Thr Gly Phe Ala Gly 
        595                 600                 605             


Gln His Asn Phe Leu Ala Lys Leu Ser Thr Tyr His Asp Phe Lys Lys 
    610                 615                 620                 


Ile Phe Gly Glu Arg Val Asp His Thr Asp Leu Gln Pro Asp Phe Glu 
625                 630                 635                 640 


Arg Ile Val Glu Trp Cys Thr Ile Phe Glu Asp Arg His Ile Tyr Arg 
                645                 650                 655     


Glu Lys Leu Lys Glu Ile Gln Trp Leu Ser Gln Ser Glu Ile Asp Gln 
            660                 665                 670         


Leu Val Leu Ile Arg Asn His Gly Trp Gly Arg Leu Ser Lys Arg Leu 
        675                 680                 685             


Leu Thr Gly Ile Arg Asp Ser Asp Gly Arg Thr Val Met Asp Gln Leu 
    690                 695                 700                 


Trp Phe Gly Thr Asp Asn Phe Met Arg Ile Ile Ser Gln Ser Asp Phe 
705                 710                 715                 720 


Ala Ala Ala Ile Ala Asn Glu Asn Arg Thr Gln Leu Asn Gln His Gly 
                725                 730                 735     


Leu Glu Asp Val Leu Asp Ser Ala Phe Met Ser Pro Gln Asn Lys Lys 
            740                 745                 750         


Ala Ile Arg Gln Val Leu Lys Val Val Asp Asp Ile Glu Gln Thr Leu 
        755                 760                 765             


Gly Cys Pro Pro Lys Lys Val Met Ile Glu Phe Thr Arg Ser Pro Asp 
    770                 775                 780                 


Lys Lys Lys Gln Arg Thr Val Thr Arg Leu Glu Lys Val Gln Gln Ala 
785                 790                 795                 800 


Tyr Lys Ala Val Ala Asp Gln Leu Ala Gly Gln Ser Ile Val Ser Glu 
                805                 810                 815     


Leu Asp Gln Tyr Ala Asn Thr His Ser Lys Leu Ser Asp Thr Tyr Tyr 
            820                 825                 830         


Leu Tyr Phe Met Gln Leu Gly Arg Asp Leu Tyr Ser Gly Lys Pro Ile 
        835                 840                 845             


Asp Ile Asp Ser Pro Met Leu Asp Asp Asp His Ile Leu Pro Arg Ala 
    850                 855                 860                 


Phe Met Lys Asp Asn Ser Leu Asp Asn Arg Ala Leu Thr Glu Lys Pro 
865                 870                 875                 880 


Ile Asn Asn Thr Lys Ala Ala Lys Phe Pro Ser Lys Val Phe Gly Gln 
                885                 890                 895     


Gln Lys Glu Val Thr Asp Phe Trp Lys Leu Leu Arg Arg Cys Gly Leu 
            900                 905                 910         


Met Ser Asn Ile Lys Glu Lys His Leu Tyr Leu Asp Pro Asp Asn Val 
        915                 920                 925             


Asp Lys Trp Thr Arg Arg Gly Phe Ile His Arg Gln Leu Val Glu Thr 
    930                 935                 940                 


Ser Gln Val Ile Lys Ile Val Ala Asn Ile Leu Asn Asp Arg Tyr Gln 
945                 950                 955                 960 


Gln Ser Gln Thr Glu Val Leu Glu Val Pro Ala Arg Leu Gly Thr Glu 
                965                 970                 975     


Leu Arg Glu Cys Phe Gly Trp Tyr Lys Val Arg Glu Val Asn Asp Tyr 
            980                 985                 990         


His His Val Phe Asp Ala Tyr Leu  Ala Ala Phe Ile Gly  Asn Tyr Leu 
        995                 1000                 1005             


Tyr Arg  Arg Tyr Pro Lys Leu  Gln Pro Tyr Phe Val  Tyr Gly Asn 
    1010                 1015                 1020             


Phe Ala  Glu Leu Asn Lys Ala  Gln Leu Lys Asn Ile  Lys Ser Phe 
    1025                 1030                 1035             


Asn Phe  Leu Tyr Asn Ile Thr  Asp Asn Lys Arg Val  Val Lys Asp 
    1040                 1045                 1050             


Ile Glu  Thr Gly Gln Thr Leu  Trp Asp Asp Gln Ile  Arg Gln Gln 
    1055                 1060                 1065             


Ile Gln  His Ile Tyr Glu Tyr  Lys Tyr Met Leu Thr  Ser His Glu 
    1070                 1075                 1080             


Ala Phe  Thr Gln His Lys Glu  Leu Tyr Gly Gln Thr  Ile Tyr Pro 
    1085                 1090                 1095             


Arg Arg  Glu Phe Lys Pro Gly  Thr Leu Lys Ala Ile  Lys Gln Asp 
    1100                 1105                 1110             


Gln Pro  Gln Glu Leu Tyr Gly  Gly Tyr Lys Asn Leu  Thr Ala Ala 
    1115                 1120                 1125             


Tyr Met  Cys Ile Val Lys Ile  Gln Ala Arg Lys Arg  Arg Ala Ala 
    1130                 1135                 1140             


Glu Tyr  Arg Val Val Arg Val  Ala Thr Glu Ser Leu  Ser Ala Leu 
    1145                 1150                 1155             


Gln Gln  Ala Lys Arg Leu Gly  Val Gln Ala Tyr Glu  Arg Cys Leu 
    1160                 1165                 1170             


Arg Gln  Glu Leu Val Arg Asn  Asn Glu Ile Leu Arg  Thr Asn Ala 
    1175                 1180                 1185             


Asp Pro  Asn Ser Ala Pro Arg  Glu Phe Glu Val Leu  Leu Asp Arg 
    1190                 1195                 1200             


Val Leu  Cys His Gln Met Ile  Ile Ser Asp Gly Gln  Lys Tyr Leu 
    1205                 1210                 1215             


Leu Gly  Ser His Ala Tyr Lys  Ile Asn Cys Met Gln  Leu Val Leu 
    1220                 1225                 1230             


Ser Asn  Asn Ser Met Lys Ile  Leu Ser Thr Ser Ile  Val Lys Leu 
    1235                 1240                 1245             


Lys Gln  Met Thr Asn Glu Pro  Leu Val Gln Val Tyr  Arg Glu Ile 
    1250                 1255                 1260             


Leu Asp  Val Val Asn Lys Tyr  Phe Thr Leu Tyr Asp  Val Asn Ser 
    1265                 1270                 1275             


Phe Arg  Glu Asn Leu Asn Gln  Phe Phe Asp Lys Phe  Arg Thr Leu 
    1280                 1285                 1290             


Pro Ile  Thr Asn Glu Tyr Glu  Ser Ser Lys Ser Gly  Lys Lys Leu 
    1295                 1300                 1305             


Ile His  Arg Gly Gln Leu Glu  Thr Leu Thr Leu Ile  Leu Arg Gly 
    1310                 1315                 1320             


Leu His  Ala Asn Ser Asp Lys  Val Gln Tyr Gly Asp  Gln Ser Thr 
    1325                 1330                 1335             


Leu Leu  Gly Gly Phe Gln Thr  Lys Asp Gly Ile Lys  Leu Ser Lys 
    1340                 1345                 1350             


Asp Ser  Val Ile Gln Tyr Thr  Ser Pro Ala Gly Leu  Asn Val Arg 
    1355                 1360                 1365             


Thr Val  Lys Leu Arg Asp Leu  Glu Gln Lys Glu Ala  Gln Lys 
    1370                 1375                 1380         


<210> 292
<211> 1361
<212> PRT
<213> Lactobacillus pentosus


<220>
<223> Lactobacillus pentosus KCA1

<400> 292
Met Asn Glu Pro Tyr Gly Val Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Thr Val Val Asp Met Asn Gly Arg Val Arg Lys Val Lys Gly 
            20                  25                  30          


Lys Thr Ala Leu Gly Ala Arg Leu Phe Lys Glu Gly Ala Thr Ala Glu 
        35                  40                  45              


Asp Arg Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Lys Arg Val Lys 
    50                  55                  60                  


Trp Arg Leu Arg Leu Leu Arg Glu Phe Phe Asp Gln Pro Ile Ser Lys 
65                  70                  75                  80  


Ile Asp Pro Asn Phe Phe Ala Arg Arg Lys Tyr Ser Asp Ile Ser Pro 
                85                  90                  95      


Arg Asp Pro Asn Tyr Asn Gly Leu Ala Lys Thr Leu Phe Asn Asp Arg 
            100                 105                 110         


Thr Asp Lys Glu Phe Tyr Asp Asp Tyr Ala Thr Ile Tyr His Leu Arg 
        115                 120                 125             


Asp Lys Leu Met Thr Ser Asn Arg Lys Phe Asp Ile Arg Glu Ile Tyr 
    130                 135                 140                 


Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Arg Thr 
145                 150                 155                 160 


Gly Pro Ala Ser Gln Tyr Gly Ser Ala Ser Leu His Leu Ala Thr Ser 
                165                 170                 175     


Phe Gln Lys Leu Asn Asp Leu Phe Ala Gln Ser Glu Glu Thr Leu Asn 
            180                 185                 190         


Leu Lys Leu Val Thr Asp Glu Ala Leu Leu Gln Gln Ile Gln Gln Ile 
        195                 200                 205             


Leu Val Arg Thr Asp Leu Ser Arg Ser Glu Gln Gln Arg Gln Ile Trp 
    210                 215                 220                 


Pro Leu Met Ala Val Leu Thr Gly Ala Ser Ala Ala Glu Lys Lys Arg 
225                 230                 235                 240 


Gln Lys Asn Val Val Val Glu Leu Ser Lys Ala Leu Val Gly Leu Lys 
                245                 250                 255     


Ala Lys Met Asn Val Val Thr Leu Thr Glu Val Asp Ala Ala Val Val 
            260                 265                 270         


Lys Asp Trp Thr Phe Thr Met Glu Glu Ser Gln Asp Lys Leu Pro Glu 
        275                 280                 285             


Ile Glu Glu Gln Leu Ser Glu Val Gly Gln Gln Ile Met Asp Glu Val 
    290                 295                 300                 


Ile Gln Leu Tyr Ala Ser Val Asn Leu Ala Gln Leu Ile Pro Ala Gly 
305                 310                 315                 320 


Lys Arg Phe Ser Gln His Met Val Glu Lys Tyr Lys His His Glu Lys 
                325                 330                 335     


Asn Leu Glu Leu Leu Lys Ala Tyr Ile His Ser Gln Ser Asp Ser Lys 
            340                 345                 350         


Arg Gly Arg Glu Ile Arg Ala Thr Tyr Asp Arg Tyr Ile Asp Gly Val 
        355                 360                 365             


Asp Ser Lys Pro Val Thr Gln Glu Met Phe Tyr Lys Asp Leu Met Lys 
    370                 375                 380                 


Tyr Val Glu Ala Asp Ala Thr Ser Asn His Leu Ala Ala Glu Ile Lys 
385                 390                 395                 400 


Asp Glu Ile Asp Ser Glu Gln Phe Met Pro Lys Leu Arg Thr Lys Gln 
                405                 410                 415     


Asn Gly Ser Ile Pro Tyr Gln Val Gln Gln Tyr Glu Leu Asp Gln Ile 
            420                 425                 430         


Ile Ser His Gln Lys Lys Tyr Tyr Pro Trp Leu Gly Glu Glu Asn Pro 
        435                 440                 445             


Val Ala Glu Arg Arg Gly Lys Phe Pro Tyr Lys Leu Asp Glu Leu Val 
    450                 455                 460                 


Gly Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Ile Thr Lys Glu Asp 
465                 470                 475                 480 


Gln Gln Ala Thr Ser Gly Ala Gly Phe Ala Trp Met Val Arg Lys Ala 
                485                 490                 495     


Asp Gly Pro Ile Thr Pro Trp Asn Phe Asp Gln Lys Val Asp Arg Ile 
            500                 505                 510         


Ala Ser Ala Thr Ala Phe Ile Gln Arg Met Gln Thr Thr Asp Thr Tyr 
        515                 520                 525             


Leu Ile Gly Glu Asp Val Leu Pro Ala Arg Ser Leu Ile Tyr Gln Arg 
    530                 535                 540                 


Phe Met Val Leu Asn Glu Leu Asn Asn Met Arg Val Glu Asp Arg Lys 
545                 550                 555                 560 


Leu Ala Pro Gln Gln Lys Gln Arg Leu Tyr Asn Gln Val Phe Lys Gln 
                565                 570                 575     


His Gln His Val Ser Val Lys Asn Ile Gln Gln Asn Leu Met Asp Ala 
            580                 585                 590         


Gly Glu Tyr Arg Lys Thr Pro Gln Ile Thr Gly Leu Ala Asp Pro Lys 
        595                 600                 605             


Gly Phe Asn Ser Ser Leu Ser Thr Tyr His Asp Phe Lys Lys Ile Leu 
    610                 615                 620                 


Leu Glu Ala Ile Ala Asp Glu His Lys Arg Ala Asp Ile Glu Lys Ile 
625                 630                 635                 640 


Ile Leu Trp Ser Thr Thr Phe Glu Asp Ser Ala Ile Phe Lys Gln Lys 
                645                 650                 655     


Leu Glu Glu Val Ala Trp Leu Thr Asp Ala Gln Arg Lys Gln Leu Ser 
            660                 665                 670         


Gly Leu Arg Tyr Arg Gly Trp Gly Gln Leu Ser His Lys Leu Leu Thr 
        675                 680                 685             


Ala Phe Lys Asp Asp Lys Gly Arg Ser Ile Met Asp Gly Leu Trp Glu 
    690                 695                 700                 


Thr Ser Asp Asn Phe Met Gln Leu Arg Lys Gln Pro Ala Ile Glu Thr 
705                 710                 715                 720 


Gln Ile Lys Glu Ala Asn Gln Ala Asn Leu Thr Asp Ala Asp Ile Gln 
                725                 730                 735     


Asp Thr Ile Asn Glu Leu Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile 
            740                 745                 750         


Arg Glu Val Met Leu Val Leu Asp Asp Ile Lys Asn Ala Met His Gly 
        755                 760                 765             


Gln Thr Pro Ser Trp Ile Phe Val Glu Ala Ala Arg Gly Gly Gly Val 
    770                 775                 780                 


Ala Gly Arg Arg Thr Gln Ser Arg Ser Ser Gln Ile Val Glu Ala Tyr 
785                 790                 795                 800 


Lys Gly Thr Ala Lys Glu Ile Val Ser Glu Lys Val Gln His Glu Leu 
                805                 810                 815     


Asn Glu Lys Ile Lys Ala Lys Ala Asp Phe Asn Thr Arg Leu Val Leu 
            820                 825                 830         


Tyr Phe Leu Gln Asn Gly Arg Asp Leu Tyr Thr Asn Glu Ala Ile Asn 
        835                 840                 845             


Ile Asp Arg Leu Ser Glu Tyr Asp Ile Asp His Ile Leu Pro Gln Ser 
    850                 855                 860                 


Leu Val Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ala Arg 
865                 870                 875                 880 


Ile Asn Arg Glu Lys Asn Asp Thr Phe Ala Ser Glu Lys Phe Gly Arg 
                885                 890                 895     


Lys Met Gly Ala Gln Trp Arg Glu Leu His Arg Asn Gly Leu Met Thr 
            900                 905                 910         


Gln Arg Lys Leu Lys His Leu Leu Met Arg Pro Asp Glu Ile Ser Lys 
        915                 920                 925             


His Ala Thr Asp Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Val 
    930                 935                 940                 


Ile Lys Leu Val Glu Glu Leu Ile Ser Ser Glu Tyr Pro Ala Ala Ser 
945                 950                 955                 960 


Ile Val Ala Val Lys Ala Asn Leu Thr His Gln Phe Arg Gln Thr Phe 
                965                 970                 975     


Asn Phe Pro Lys Leu Arg Glu Val Asn Asp Tyr His His Ala Phe Asp 
            980                 985                 990         


Ala Ser Leu Thr Ala Phe Ile Gly  Met Tyr Leu Leu Lys  Gln Tyr Pro 
        995                 1000                 1005             


Lys Leu  Glu Arg Phe Phe Val  Tyr Gly Lys Phe Ala  Lys Gln Pro 
    1010                 1015                 1020             


Ile Asn  Leu Thr Arg Phe Asn  Ile Ile Arg Lys Leu  Ala Val Ala 
    1025                 1030                 1035             


Glu Lys  Pro Ile Ala Asn Ile  Glu Thr Gly Glu Ile  Leu Trp Asp 
    1040                 1045                 1050             


Lys Thr  Ala Asp Ile Lys Tyr  Phe Glu Lys Leu Tyr  Asn Tyr Lys 
    1055                 1060                 1065             


Arg Leu  Leu Val Thr His Glu  Val Arg Glu Asn Tyr  Gly Ala Met 
    1070                 1075                 1080             


Phe Lys  Gln Thr Leu Phe Lys  Ala Ser Tyr Asn Lys  Ser Lys Thr 
    1085                 1090                 1095             


Leu Val  Pro Lys Lys Asn His  Met Glu Thr Ser Val  Tyr Gly Gly 
    1100                 1105                 1110             


Tyr Ser  Asn Gln Glu Thr Ala  Tyr Leu Ala Ile Val  Arg Ile Pro 
    1115                 1120                 1125             


Phe Lys  Ser Gly Phe Lys Phe  Ile Val Val Gly Ile  Pro Thr Arg 
    1130                 1135                 1140             


Met Val  Ala Lys Ile Lys His  Tyr Gln Ser Leu Gly  Ala Thr Leu 
    1145                 1150                 1155             


Asn Gln  Ala Thr His Lys Val  Ile Glu Pro Lys Phe  Thr Lys Ile 
    1160                 1165                 1170             


Ser Arg  Lys Thr Lys Gln Thr  Val Ile Ser Asp Tyr  Glu Val Val 
    1175                 1180                 1185             


Leu Pro  Lys Val Tyr Leu Asp  Gln Val Val Arg Asp  Gln Val Lys 
    1190                 1195                 1200             


Gly Gln  Met Tyr Arg Phe Ser  Leu Gly Ser Asp Lys  Glu Tyr His 
    1205                 1210                 1215             


Asn Val  Gln Glu Leu Tyr Leu  Pro Leu Ser Ile Gln  Gln Ala Phe 
    1220                 1225                 1230             


Val Gly  His Tyr Asp Glu Ser  Asp Asp Gln Arg Ser  Asn Asp Leu 
    1235                 1240                 1245             


Val Lys  Val Tyr Asp Ala Ala  Leu Lys Gln Leu Gln  Arg Tyr Phe 
    1250                 1255                 1260             


Pro Leu  His Leu Ser Arg Asn  Phe Asp Gln Val Ala  Ser Gln Ala 
    1265                 1270                 1275             


His Gln  Ser Phe Glu Gly Leu  Lys Asn Asn Val Gln  Thr Ser Asp 
    1280                 1285                 1290             


Lys Gln  Leu Gly Lys Lys Glu  Val Leu Asn Ser Leu  Phe Val Gly 
    1295                 1300                 1305             


Leu His  Ala Asn Ala Thr Arg  Ser Asn Leu Ser Val  Leu Gly Met 
    1310                 1315                 1320             


Ser Lys  Asp Phe Gly Arg Ile  Lys Ser Asn Gly Ile  Thr Leu Thr 
    1325                 1330                 1335             


Asp Gln  Ala Glu Ile Ile Tyr  Gln Ser Pro Thr Gly  Leu Phe Glu 
    1340                 1345                 1350             


Arg Lys  Val Ala Leu Lys Asp  Leu 
    1355                 1360     


<210> 293
<211> 1358
<212> PRT
<213> Lactobacillus pentosus


<220>
<223> Lactobacillus pentosus MP-10

<400> 293
Met Asn Glu Pro Tyr Gly Val Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Thr Val Val Asp Met Asn Gly Arg Val Arg Lys Val Lys Gly 
            20                  25                  30          


Lys Thr Ala Leu Gly Ala Arg Leu Phe Lys Glu Gly Ala Thr Ala Glu 
        35                  40                  45              


Asp Arg Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Lys Arg Val Lys 
    50                  55                  60                  


Trp Arg Leu Arg Leu Leu Arg Glu Phe Phe Asp Gln Pro Ile Ser Lys 
65                  70                  75                  80  


Ile Asp Pro Asn Phe Phe Ala Arg Arg Lys Tyr Ser Asp Ile Ser Pro 
                85                  90                  95      


Arg Asp Pro Asn Tyr Asn Gly Leu Ala Lys Thr Leu Phe Asn Asp Arg 
            100                 105                 110         


Thr Asp Gln Glu Phe Tyr His Asp Tyr Pro Thr Ile Tyr His Leu Arg 
        115                 120                 125             


Asp Lys Leu Met Thr Ser Asp Arg Lys Phe Asp Ile Arg Glu Ile Tyr 
    130                 135                 140                 


Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Arg Thr 
145                 150                 155                 160 


Gly Pro Ala Ser Gln Tyr Gly Ser Ala Ser Leu His Leu Ala Thr Ser 
                165                 170                 175     


Phe Gln Lys Leu Asn Asp Leu Phe Ala Gln Ser Glu Glu Ser Leu Asn 
            180                 185                 190         


Phe Lys Leu Val Thr Asp Glu Ala Gln Leu Gln Gln Ile Gln Gln Ile 
        195                 200                 205             


Leu Val Arg Thr Asp Leu Ser Arg Ser Glu Gln Gln Arg Gln Ile Trp 
    210                 215                 220                 


Pro Leu Met Val Val Leu Met Gly Ala Thr Ala Ala Glu Lys Lys Arg 
225                 230                 235                 240 


Gln Lys Asp Phe Ala Lys Glu Leu Ala Asn Ala Leu Val Gly Leu Lys 
                245                 250                 255     


Ala Lys Leu Asn Val Val Thr Leu Thr Asn Val Asp Thr Thr Val Val 
            260                 265                 270         


Lys Asp Trp Thr Phe Thr Leu Glu Glu Ser Gln Asp Lys Leu Pro Glu 
        275                 280                 285             


Ile Glu Glu Gln Leu Ser Glu Val Gly Gln Gln Ile Met Asp Glu Val 
    290                 295                 300                 


Ile Gln Leu Tyr Ala Ser Val Asn Leu Ala Gln Leu Ile Pro Ala Gly 
305                 310                 315                 320 


Lys Arg Phe Ser Gln His Met Val Glu Lys Tyr Asn His His Glu Lys 
                325                 330                 335     


Asn Leu Glu Leu Leu Lys Ala Tyr Ile His Ser Gln Ser Asp Ser Lys 
            340                 345                 350         


Arg Gly Arg Glu Ile Arg Ala Thr Tyr Asp Arg Tyr Ile Asp Gly Val 
        355                 360                 365             


Lys Ser Lys Pro Val Thr Gln Glu Met Phe Tyr Lys Asp Leu Met Lys 
    370                 375                 380                 


Tyr Val Glu Ala Asp Ala Thr Ser Asn His Leu Ala Ala Glu Ile Lys 
385                 390                 395                 400 


Asp Glu Ile Asp Ser Glu Gln Phe Met Pro Lys Leu Arg Thr Lys Gln 
                405                 410                 415     


Asn Gly Ser Ile Pro Tyr Gln Val Gln Gln Tyr Glu Leu Asp Gln Ile 
            420                 425                 430         


Ile Ser His Gln Lys Lys Tyr Tyr Pro Trp Leu Gly Glu Glu Asn Pro 
        435                 440                 445             


Val Ala Glu Arg Arg Gly Lys Phe Pro Tyr Lys Leu Asp Glu Leu Val 
    450                 455                 460                 


Gly Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Ile Thr Lys Glu Asp 
465                 470                 475                 480 


Gln Gln Ala Thr Ser Gly Ala Gly Phe Ala Trp Met Val Arg Lys Ala 
                485                 490                 495     


Asp Gly Pro Ile Thr Pro Trp Asn Phe Asp Gln Lys Val Asp Arg Ile 
            500                 505                 510         


Ala Ser Ala Thr Ala Phe Ile Gln Arg Met Gln Thr Thr Asp Thr Tyr 
        515                 520                 525             


Leu Ile Gly Glu Asp Val Leu Pro Ala Arg Ser Leu Ile Tyr Gln Arg 
    530                 535                 540                 


Phe Met Val Leu Asn Glu Leu Asn Asn Met Arg Val Glu Asp Gln Lys 
545                 550                 555                 560 


Leu Ala Pro Arg Gln Lys Gln Arg Leu Tyr Asn Gln Val Phe Lys Gln 
                565                 570                 575     


His Gln His Val Ser Val Lys Asn Ile Gln Gln Asn Leu Met Asp Ala 
            580                 585                 590         


Gly Glu Tyr Arg Glu Thr Pro Lys Ile Thr Gly Leu Ala Asp Pro Lys 
        595                 600                 605             


Gly Phe Asn Ser Ser Leu Ser Thr Tyr His Asp Phe Lys Lys Ile Leu 
    610                 615                 620                 


Pro Glu Ala Ile Ala Asp Glu His Lys Arg Ala Asp Ile Glu Lys Ile 
625                 630                 635                 640 


Ile Leu Trp Ser Thr Thr Phe Glu Asp Ser Ala Ile Phe Lys Gln Lys 
                645                 650                 655     


Leu Glu Glu Val Ala Trp Leu Thr Asp Ala Gln Arg Lys Gln Leu Ser 
            660                 665                 670         


Gly Leu Arg Tyr Arg Gly Trp Gly Gln Leu Ser His Lys Leu Leu Thr 
        675                 680                 685             


Ala Phe Lys Asp Asp Asn Gly Arg Ser Val Met Asp Gly Leu Trp Glu 
    690                 695                 700                 


Thr Ser Asp Asn Phe Met Gln Leu Arg Lys Gln Pro Ala Ile Glu Thr 
705                 710                 715                 720 


Gln Ile Lys Glu Ala Asn Gln Ala Asn Leu Thr Asp Ala Asp Ile Gln 
                725                 730                 735     


Asp Thr Ile Asn Glu Leu Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile 
            740                 745                 750         


Arg Glu Val Met Leu Val Leu Asp Asp Ile Lys Asn Ala Met His Gly 
        755                 760                 765             


Gln Thr Pro Ser Trp Ile Phe Ile Glu Ala Ala Arg Gly Gly Gly Val 
    770                 775                 780                 


Ala Gly Arg Arg Thr Gln Ser Arg Ser Lys Gln Ile Val Glu Ala Tyr 
785                 790                 795                 800 


Lys Ser Thr Ala Lys Glu Ile Val Ser Glu Lys Val Gln His Glu Leu 
                805                 810                 815     


Asn Glu Lys Ile Lys Ala Lys Ala Asp Phe Asn Thr Arg Leu Val Leu 
            820                 825                 830         


Tyr Phe Leu Gln Asn Gly Arg Asp Leu Tyr Thr Asn Glu Ala Ile Asn 
        835                 840                 845             


Ile Asp Arg Leu Ser Glu Tyr Asp Ile Asp His Ile Leu Pro Gln Ser 
    850                 855                 860                 


Leu Val Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ala Arg 
865                 870                 875                 880 


Ile Asn Arg Glu Lys Asn Asp Thr Phe Ala Ser Glu Lys Phe Gly Arg 
                885                 890                 895     


Lys Met Gly Ala Gln Trp Arg Glu Leu His Arg Asn Gly Leu Met Thr 
            900                 905                 910         


Gln Arg Lys Leu Lys His Leu Leu Met Arg Pro Asp Glu Ile Ser Lys 
        915                 920                 925             


His Ala Thr Asp Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Val 
    930                 935                 940                 


Ile Lys Leu Val Glu Glu Leu Ile Ser Ser Glu Tyr Pro Ser Ala Ser 
945                 950                 955                 960 


Ile Val Ala Val Lys Ala Asn Leu Thr His Gln Phe Arg Gln Thr Phe 
                965                 970                 975     


Asn Phe Pro Lys Leu Arg Glu Val Asn Asp Tyr His His Ala Phe Asp 
            980                 985                 990         


Ala Ser Leu Thr Ala Phe Ile Gly  Met Tyr Leu Leu Lys  Gln Tyr Pro 
        995                 1000                 1005             


Lys Leu  Glu Arg Phe Phe Val  Tyr Gly Lys Phe Ala  Lys Gln Pro 
    1010                 1015                 1020             


Ile Asn  Leu Thr Arg Phe Asn  Val Ile Arg Lys Leu  Ala Val Ala 
    1025                 1030                 1035             


Glu Glu  Pro Ile Ala Asn Ile  Glu Thr Gly Glu Ile  Leu Trp Asp 
    1040                 1045                 1050             


Lys Thr  Ala Asp Ile Lys Cys  Phe Glu Lys Leu Tyr  Asn Tyr Lys 
    1055                 1060                 1065             


Arg Leu  Leu Val Thr His Glu  Val Arg Glu Asn Tyr  Gly Ala Met 
    1070                 1075                 1080             


Phe Asp  Gln Thr Ile Phe Lys  Ala Thr Asp Ser Arg  Lys Arg Leu 
    1085                 1090                 1095             


Ile Gln  Lys Lys Lys Gly Phe  Ala Thr Glu Thr Tyr  Gly Gly Tyr 
    1100                 1105                 1110             


Thr Gly  Arg Thr Leu Ala Tyr  Leu Ala Ile Val Lys  Val Val Thr 
    1115                 1120                 1125             


Asn Lys  Asp Thr Gln Tyr Gln  Val Val Gly Ile Pro  Thr Thr Met 
    1130                 1135                 1140             


Val Thr  Gln Ile Gln Gln Leu  Glu Ala Ser Gly Leu  Thr Ser Lys 
    1145                 1150                 1155             


Gln Ala  Val Thr Lys Ala Ile  Gly Ala Met Ile Asn  Glu Asn Asn 
    1160                 1165                 1170             


Lys Lys  Leu Gln Ser Tyr Glu  Val Leu Leu Pro Lys  Val Arg Phe 
    1175                 1180                 1185             


Glu Gln  Val Val Arg Asp Glu  Val Lys Gly His Ile  His Arg Phe 
    1190                 1195                 1200             


Ala Leu  Gly Thr Asp Thr Tyr  Tyr His Asn Ile Gln  Glu Leu Tyr 
    1205                 1210                 1215             


Leu Pro  Leu Thr Ile Gln Arg  Ala Phe Leu Gly Lys  Arg Asn Asp 
    1220                 1225                 1230             


Thr Asp  Ala Gln Thr Glu Gln  Asn Leu Leu Thr Val  Phe Glu Thr 
    1235                 1240                 1245             


Thr Leu  Ala Gln Val Asn Arg  Tyr Phe Pro Leu Tyr  Glu Met Asn 
    1250                 1255                 1260             


Lys Phe  Lys Gln Ile Leu Asn  Ser Ala Gln Glu Lys  Phe Ala Ala 
    1265                 1270                 1275             


Leu Pro  Thr Lys Asn Lys Thr  Val Lys Asn Lys Leu  Val Thr Gly 
    1280                 1285                 1290             


Lys Asp  Gly Val Leu Asn Asn  Leu Phe Ile Gly Leu  His Ala Asn 
    1295                 1300                 1305             


Ala Ser  Leu Gly Asp Leu Lys  Ile Leu Gly Met Lys  Ile Gly Phe 
    1310                 1315                 1320             


Gly Lys  Leu Gln Val Pro Gly  Gly Leu Lys Leu Thr  Asp Gln Ala 
    1325                 1330                 1335             


Glu Ile  Ile Tyr Gln Ser Pro  Thr Gly Leu Phe Glu  Arg Lys Val 
    1340                 1345                 1350             


Ala Leu  Lys Asp Leu 
    1355             


<210> 294
<211> 1358
<212> PRT
<213> Lactobacillus plantarum

<400> 294
Met Lys Glu Pro Tyr Gly Val Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Thr Val Val Asp Ala Ser Gly His Val Arg Lys Ile Lys Gly 
            20                  25                  30          


Gln Thr Gly Ile Gly Val Arg Leu Phe Lys Glu Gly Ala Ala Ala Ala 
        35                  40                  45              


Asp Arg Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Lys Arg Val Lys 
    50                  55                  60                  


Trp Arg Leu Arg Leu Leu Arg Glu Phe Phe Asp Gln Pro Ile Ser Lys 
65                  70                  75                  80  


Val Asp Ile Asn Phe Phe Ala Arg Arg Lys Tyr Ser Asp Val Ser Pro 
                85                  90                  95      


Arg Asp Pro Asn Tyr Asn Gly Leu Glu Lys Thr Leu Phe Asn Asp Arg 
            100                 105                 110         


Ser Asp Gln Asp Phe Tyr His Asp Tyr Pro Thr Ile Tyr His Leu Arg 
        115                 120                 125             


Glu Ala Leu Met Thr Gln His Arg Lys Phe Asp Val Arg Glu Ile Tyr 
    130                 135                 140                 


Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Arg Asn 
145                 150                 155                 160 


Asp Ala Ala Thr Ala Tyr Arg Ser Gly Thr Leu Asp Leu Gln Gln His 
                165                 170                 175     


Phe Glu Thr Leu Asn His Leu Phe Ser Gln Ala Asp Leu Glu Leu Asn 
            180                 185                 190         


Leu Asn Leu Thr Thr Asp Val Ala Leu Leu Asp Ser Ile Lys Gln Thr 
        195                 200                 205             


Leu Val Arg Thr Asp Ile Ser Arg Ser Asp Arg Gln Lys Leu Ile Met 
    210                 215                 220                 


Pro Leu Leu Ala Val Leu Thr Gly Ala Thr Thr Ala Glu Lys Lys Arg 
225                 230                 235                 240 


Gln Lys Ala Val Val Thr Glu Phe Ala Lys Ala Leu Val Gly Asn Lys 
                245                 250                 255     


Thr Lys Ile Asp Val Leu Thr Leu Thr Asp Ile Asp Ala Thr Glu Ala 
            260                 265                 270         


Lys Asp Trp Ala Phe Ser Leu Glu Glu Asn Gln Asp Lys Leu Pro Gly 
        275                 280                 285             


Ile Glu Asp Arg Phe Ser Glu Val Gly Gln Gln Ile Ile Asp Glu Val 
    290                 295                 300                 


Ile Arg Leu Tyr Ala Ser Val Asn Leu Ala Gln Leu Ile Pro Glu Gly 
305                 310                 315                 320 


Lys Arg Phe Ser Gln Ser Met Val Glu Lys Tyr Lys Arg His Gly Glu 
                325                 330                 335     


Asp Leu Lys Leu Leu Lys Ala Tyr Ile Arg Ser Gln Ser Asp Ala Lys 
            340                 345                 350         


Arg Gly Arg Ala Ile Arg Ala Thr Tyr Asp Gln Tyr Ile Asp Gly Val 
        355                 360                 365             


Lys Ser Lys Gln Val Thr Gln Glu Ala Phe Gln Lys Ala Leu Gly Lys 
    370                 375                 380                 


Phe Val Asp Ala Asp Val Asp Leu Asn Ser Trp Ala Ala Gln Ile Lys 
385                 390                 395                 400 


Gln Ala Ile Asp Ser Glu Gln Phe Met Pro Lys Leu Arg Thr Lys Gln 
                405                 410                 415     


Asn Gly Ala Ile Pro Tyr Gln Val Gln Gln Asn Glu Leu Asp Gln Ile 
            420                 425                 430         


Ile Ser Asn Gln Lys Glu Tyr Tyr Pro Trp Leu Gly Glu Glu Asn Pro 
        435                 440                 445             


Val Ile Lys Arg Arg Gly Lys Phe Pro Tyr Lys Leu Asp Glu Leu Phe 
    450                 455                 460                 


Gly Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Ile Thr Lys Glu Met 
465                 470                 475                 480 


Gln Ala Ala Thr Ala Asn Ala Gly Phe Ala Trp Met Val Arg Lys Ala 
                485                 490                 495     


Asp Gly Pro Ile Thr Pro Trp Asn Phe Asp Asp Lys Val Asp Arg Val 
            500                 505                 510         


Ala Ser Ala Thr Ala Phe Ile Gln Arg Met Gln Thr Thr Asp Thr Tyr 
        515                 520                 525             


Leu Ile Gly Glu Glu Val Leu Pro Ala Arg Ser Leu Ile Tyr Gln Arg 
    530                 535                 540                 


Phe Met Val Leu Asn Glu Leu Asn Asn Ile Arg Val Asp Asp Gly Gln 
545                 550                 555                 560 


Leu Thr Pro Arg Gln Lys Gln Arg Leu Tyr Asn Gln Val Phe Lys Lys 
                565                 570                 575     


His Lys Arg Val Thr Ala Lys Asn Ile Gln Asp Asn Leu Val Ala Ala 
            580                 585                 590         


Arg Glu Phe Pro Thr Ala Pro Arg Ile Thr Gly Leu Ala Asp Pro Lys 
        595                 600                 605             


Val Phe Asn Ser Ser Leu Ser Thr Tyr His Asp Leu Lys Gln Val Leu 
    610                 615                 620                 


Pro Glu Ala Met Ser Asp Val Arg Lys Gln Ala Asp Ile Glu Lys Ile 
625                 630                 635                 640 


Ile Leu Trp Ser Thr Ile Phe Glu Asp Ser Thr Ile Phe Lys Gln Lys 
                645                 650                 655     


Leu Thr Glu Ile Ser Trp Leu Thr Ala Ala Gln Leu Lys Gln Leu Gly 
            660                 665                 670         


Gln Leu Arg Tyr Arg Gly Trp Gly Gln Leu Leu Arg Lys Leu Leu Thr 
        675                 680                 685             


Gly Leu Lys Asp Asp Asn Asn Arg Ser Ile Met Asp Gly Leu Trp Glu 
    690                 695                 700                 


Thr Asn Ala Asn Phe Met Gln Leu Arg Ser Gln Pro Ala Ile Glu Asn 
705                 710                 715                 720 


Gln Ile Lys Ser Ala Asn Gln Ala Asn Leu Thr Thr Ala Asp Leu Gln 
                725                 730                 735     


Asp Thr Ile Asn Glu Leu Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile 
            740                 745                 750         


Arg Glu Val Met Val Val Leu Ala Asp Ile Lys Asp Ala Met His Gly 
        755                 760                 765             


Gln Thr Pro Asn Trp Ile Phe Val Glu Ala Ala Arg Gly Gly Gly Val 
    770                 775                 780                 


Ala Gly Arg Arg Thr Gln Ser Arg Ser Lys Gln Ile Val Ala Ala Tyr 
785                 790                 795                 800 


Gln Gly Thr Ala Gln Ala Ile Val Arg Asp Gln Val Gln Arg Glu Leu 
                805                 810                 815     


Lys Glu Lys Ile Lys Asn Lys Ala Asn Phe Asn Thr Arg Leu Val Leu 
            820                 825                 830         


Tyr Phe Leu Gln Asn Gly Arg Asp Leu Tyr Thr Gly Asp Ala Ile Asn 
        835                 840                 845             


Ile Asp Arg Leu Ser Glu Tyr Asp Ile Asp His Ile Leu Pro Gln Ser 
    850                 855                 860                 


Leu Val Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Asn Ala Arg 
865                 870                 875                 880 


Ile Asn Arg Glu Lys Asn Asp Thr Phe Ala Ser Glu Lys Phe Gly Lys 
                885                 890                 895     


Lys Met Gly Ala Lys Trp Lys Glu Met His Arg Met Gly Leu Met Thr 
            900                 905                 910         


Lys Arg Lys Leu Asp His Leu Leu Met Arg Pro Asp Glu Ile Ser Lys 
        915                 920                 925             


Tyr Ala Thr Gly Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Val 
    930                 935                 940                 


Ile Lys Leu Val Glu Glu Leu Ile Asn Ala Glu Tyr Pro Ser Thr Ala 
945                 950                 955                 960 


Ile Val Ser Val Lys Ala Asn Leu Thr His Gln Phe Arg Gln Thr Phe 
                965                 970                 975     


Asp Phe Pro Lys Ile Arg Glu Val Asn Asp Tyr His His Ala Phe Asp 
            980                 985                 990         


Ala Ala Leu Thr Ala Phe Ile Gly  Thr Tyr Leu Leu Lys  Arg Tyr Pro 
        995                 1000                 1005             


Lys Leu  Glu Arg Phe Phe Val  Tyr Gly Lys Phe Ala  Lys Gln Pro 
    1010                 1015                 1020             


Val Asn  Leu Thr Arg Phe Asn  Val Ile Arg Lys Leu  Ala Lys Thr 
    1025                 1030                 1035             


Asp Thr  Pro Ile Thr Asp Ile  Asp Thr Gly Glu Val  Leu Trp Asp 
    1040                 1045                 1050             


Lys Leu  Thr Asp Ile Lys Tyr  Phe Glu Thr Leu Tyr  Asp Tyr Lys 
    1055                 1060                 1065             


Arg Leu  Leu Val Thr Arg Glu  Val Ser Glu Asn Tyr  Gly Ala Met 
    1070                 1075                 1080             


Phe Asp  Gln Thr Leu Leu Lys  Ala Ser Asp Asn Gly  Lys Arg Leu 
    1085                 1090                 1095             


Ile Arg  Lys Lys Gln Ser Phe  Asp Thr Ala Ile Tyr  Gly Gly Tyr 
    1100                 1105                 1110             


Thr Gly  Lys Thr Leu Ala Tyr  Met Ala Ile Val Lys  Val Ser Thr 
    1115                 1120                 1125             


Lys Lys  Asp Val Gln Tyr Gln  Val Val Gly Val Pro  Thr Thr Met 
    1130                 1135                 1140             


Val Thr  Gln Ile Glu Gln Leu  Glu Gln Gln Gly Met  Thr Asn Lys 
    1145                 1150                 1155             


Gln Ala  Val Thr Lys Val Ile  Glu Pro Leu Ile Ala  Ala Asn Asn 
    1160                 1165                 1170             


Lys Lys  Met Leu Thr Tyr Glu  Val Leu Leu Pro Lys  Val Arg Phe 
    1175                 1180                 1185             


Glu Gln  Val Val Arg Asp Arg  Ile Lys Gly Gln Thr  His Arg Phe 
    1190                 1195                 1200             


Ala Leu  Gly Thr Asp Thr Tyr  Tyr His Asn Ile Gln  Glu Leu Tyr 
    1205                 1210                 1215             


Leu Pro  Leu Thr Leu Gln Arg  Ala Phe Leu Gly Lys  Gln Asn Glu 
    1220                 1225                 1230             


Ser Glu  Val Gln Leu Asn Gln  Asn Leu Leu Thr Val  Phe Asp Ala 
    1235                 1240                 1245             


Thr Leu  Ala Gln Val Asn Arg  Tyr Phe Pro Leu Tyr  Glu Met Asn 
    1250                 1255                 1260             


Lys Phe  Lys Lys Ile Leu Asn  Ser Ala Arg Asp Gln  Ile Glu Leu 
    1265                 1270                 1275             


Leu Glu  Ala Lys Asn Gln Phe  Val Lys Asn Lys Leu  Val Leu Gly 
    1280                 1285                 1290             


Lys Gln  Gly Ile Leu Thr Asn  Met Phe Ile Gly Leu  His Ala Asn 
    1295                 1300                 1305             


Ala Ser  Tyr Gly Asp Leu Lys  Val Leu Gly Val Lys  Ile Asp Phe 
    1310                 1315                 1320             


Gly Lys  Leu Gln Val Pro Gly  Gly Ile Lys Leu Thr  Gly Asp Ala 
    1325                 1330                 1335             


Glu Ile  Ile Tyr Gln Ser Pro  Thr Gly Leu Phe Glu  Arg Lys Ile 
    1340                 1345                 1350             


Ala Leu  Lys Asp Leu 
    1355             


<210> 295
<211> 1363
<212> PRT
<213> Lactobacillus rhamnosus

<400> 295
Met Thr Lys Leu Asn Gln Pro Tyr Gly Ile Gly Leu Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Val Val Asp Ala Asn Ser His Leu Leu Arg 
            20                  25                  30          


Leu Lys Gly Glu Thr Ala Ile Gly Ala Arg Leu Phe Arg Glu Gly Gln 
        35                  40                  45              


Ser Ala Ala Asp Arg Arg Gly Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Thr Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Ala Pro His 
65                  70                  75                  80  


Ile Thr Lys Ile Asp Pro Asp Phe Phe Leu Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Asp Arg Phe Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Glu Asp Tyr Pro Ser Met Tyr 
        115                 120                 125             


His Leu Arg Leu His Leu Met Thr His Thr His Lys Ala Asp Pro Arg 
    130                 135                 140                 


Glu Ile Phe Leu Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Pro Gly Ala Ala Lys Asp Phe Asn Thr Asp Lys Val Asp Leu 
                165                 170                 175     


Glu Asp Ile Phe Pro Ala Leu Thr Glu Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Glu Leu Thr Phe Asp Leu Ala Lys Ala Asp Asp Phe Lys Ala 
        195                 200                 205             


Lys Leu Leu Asp Glu Gln Ala Thr Pro Ser Asp Thr Gln Lys Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ser Ser Asp Gly Glu Lys Glu Ile Val Lys Lys 
225                 230                 235                 240 


Arg Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Ile Thr Gly Leu Lys 
                245                 250                 255     


Thr Lys Phe Asn Leu Ala Leu Gly Thr Glu Val Asp Glu Ala Asp Ala 
            260                 265                 270         


Ser Asn Trp Gln Phe Ser Met Gly Gln Leu Asp Asp Lys Trp Ser Asn 
        275                 280                 285             


Ile Glu Thr Ser Met Thr Asp Gln Gly Thr Glu Ile Phe Glu Gln Ile 
    290                 295                 300                 


Gln Glu Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Met Ser Leu Ser Gln Ala Lys Val Ala Asp Tyr Gly Gln His Lys Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Thr Tyr Leu Lys Lys Leu Asn Asp His Glu 
            340                 345                 350         


Leu Ala Lys Thr Ile Arg Gly Leu Tyr Asp Arg Tyr Ile Asn Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Leu Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Glu Val Ser Glu Gln Leu Leu Asn Arg 
385                 390                 395                 400 


Met Gly Gln Ala Asn Phe Met Leu Lys Gln Arg Thr Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Ile Gln Leu Gln Gln Arg Glu Leu Asp Gln Ile Ile Ala 
            420                 425                 430         


Asn Gln Ser Lys Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 
        435                 440                 445             


Ala His Arg Trp Lys Met Pro Tyr Gln Leu Asp Glu Leu Leu Asn Phe 
    450                 455                 460                 


His Ile Pro Tyr Tyr Val Gly Pro Leu Ile Thr Pro Lys Gln Gln Ala 
465                 470                 475                 480 


Glu Ser Gly Glu Asn Val Phe Ala Trp Met Val Arg Lys Asp Pro Ser 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 
            500                 505                 510         


Ser Ala Asn Thr Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Lys Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Arg Ile Asn Asn Glu Cys Leu 
545                 550                 555                 560 


Gly Thr Asp Gln Lys Gln Arg Leu Ile Arg Glu Val Phe Glu Arg His 
                565                 570                 575     


Ser Ser Val Thr Ile Lys Gln Val Ala Asp Asn Leu Val Ala His Gly 
            580                 585                 590         


Asp Phe Ala Arg Arg Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr His Gln Leu Lys Glu Ile Leu His 
    610                 615                 620                 


Glu Ala Ile Asp Asp Pro Thr Lys Leu Leu Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Thr Trp Ser Thr Val Phe Glu Asp His Thr Ile Phe Glu Thr Lys Leu 
                645                 650                 655     


Ala Glu Ile Glu Trp Leu Asp Pro Lys Lys Ile Asn Glu Leu Ser Gly 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser Arg Lys Leu Leu Asp Gly 
        675                 680                 685             


Leu Lys Leu Gly Asn Gly His Thr Val Ile Gln Glu Leu Met Leu Ser 
    690                 695                 700                 


Asn His Asn Leu Met Gln Ile Leu Ala Asp Glu Thr Leu Lys Glu Thr 
705                 710                 715                 720 


Met Thr Glu Leu Asn Gln Asp Lys Leu Lys Thr Asp Asp Ile Glu Asp 
                725                 730                 735     


Val Ile Asn Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Arg Val Val Glu Asp Ile Lys His Ala Ala Asn Gly Gln 
        755                 760                 765             


Asp Pro Ser Trp Leu Phe Ile Glu Thr Ala Asp Gly Thr Gly Thr Ala 
    770                 775                 780                 


Gly Lys Arg Thr Gln Ser Arg Gln Lys Gln Ile Gln Thr Val Tyr Ala 
785                 790                 795                 800 


Asn Ala Ala Gln Glu Leu Ile Asp Ser Ala Val Arg Gly Glu Leu Glu 
                805                 810                 815     


Asp Lys Ile Ala Asp Lys Ala Ser Phe Thr Asp Arg Leu Val Leu Tyr 
            820                 825                 830         


Phe Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Ala Pro Leu Asn Ile 
        835                 840                 845             


Asp Gln Leu Ser His Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu 
    850                 855                 860                 


Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Val Asn Ala Thr Ile 
865                 870                 875                 880 


Asn Arg Glu Lys Asn Asn Val Phe Ala Ser Thr Leu Phe Ala Gly Lys 
                885                 890                 895     


Met Lys Ala Thr Trp Arg Lys Trp His Glu Ala Gly Leu Ile Ser Gly 
            900                 905                 910         


Arg Lys Leu Arg Asn Leu Met Leu Arg Pro Asp Glu Ile Asp Lys Phe 
        915                 920                 925             


Ala Lys Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile 
    930                 935                 940                 


Lys Leu Thr Glu Gln Ile Ala Ala Ala Gln Tyr Pro Asn Thr Lys Ile 
945                 950                 955                 960 


Ile Ala Val Lys Ala Gly Leu Ser His Gln Leu Arg Glu Glu Leu Asp 
                965                 970                 975     


Phe Pro Lys Asn Arg Asp Val Asn His Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Phe Leu Ala Ala Arg Ile Gly Thr  Tyr Leu Leu Lys Arg  Tyr Pro Lys 
        995                 1000                 1005             


Leu Ala  Pro Phe Phe Thr Tyr  Gly Glu Phe Ala Lys  Val Asp Val 
    1010                 1015                 1020             


Lys Lys  Phe Arg Glu Phe Asn  Phe Ile Gly Ala Leu  Thr His Ala 
    1025                 1030                 1035             


Lys Lys  Asn Ile Ile Ala Lys  Asp Thr Gly Glu Ile  Val Trp Asp 
    1040                 1045                 1050             


Lys Glu  Arg Asp Ile Arg Glu  Leu Asp Arg Ile Tyr  Asn Phe Lys 
    1055                 1060                 1065             


Arg Met  Leu Ile Thr His Glu  Val Tyr Phe Glu Thr  Ala Asp Leu 
    1070                 1075                 1080             


Phe Lys  Gln Thr Ile Tyr Ala  Ala Lys Asp Ser Lys  Glu Arg Gly 
    1085                 1090                 1095             


Gly Ser  Lys Gln Leu Ile Pro  Lys Lys Gln Gly Tyr  Pro Thr Gln 
    1100                 1105                 1110             


Val Tyr  Gly Gly Tyr Thr Gln  Glu Ser Gly Ser Tyr  Asn Ala Leu 
    1115                 1120                 1125             


Val Arg  Val Ala Glu Ala Asp  Thr Thr Ala Tyr Gln  Val Ile Lys 
    1130                 1135                 1140             


Ile Ser  Ala Gln Asn Ala Ser  Lys Ile Ala Ser Ala  Asn Leu Lys 
    1145                 1150                 1155             


Ser Arg  Glu Lys Gly Lys Gln  Leu Leu Asn Glu Ile  Val Val Lys 
    1160                 1165                 1170             


Gln Leu  Ala Lys Arg Arg Lys  Asn Trp Lys Pro Ser  Ala Asn Ser 
    1175                 1180                 1185             


Phe Lys  Ile Val Ile Pro Arg  Phe Gly Met Gly Thr  Leu Phe Gln 
    1190                 1195                 1200             


Asn Ala  Lys Tyr Gly Leu Phe  Met Val Asn Ser Asp  Thr Tyr Tyr 
    1205                 1210                 1215             


Arg Asn  Tyr Gln Glu Leu Trp  Leu Ser Arg Glu Asn  Gln Lys Leu 
    1220                 1225                 1230             


Leu Lys  Lys Leu Phe Ser Ile  Lys Tyr Glu Lys Thr  Gln Met Asn 
    1235                 1240                 1245             


His Asp  Ala Leu Gln Val Tyr  Lys Ala Ile Ile Asp  Gln Val Glu 
    1250                 1255                 1260             


Lys Phe  Phe Lys Leu Tyr Asp  Ile Asn Gln Phe Arg  Ala Lys Leu 
    1265                 1270                 1275             


Ser Asp  Ala Ile Glu Arg Phe  Glu Lys Leu Pro Ile  Asn Thr Asp 
    1280                 1285                 1290             


Gly Asn  Lys Ile Gly Lys Thr  Glu Thr Leu Arg Gln  Ile Leu Ile 
    1295                 1300                 1305             


Gly Leu  Gln Ala Asn Gly Thr  Arg Ser Asn Val Lys  Asn Leu Gly 
    1310                 1315                 1320             


Ile Lys  Thr Asp Leu Gly Leu  Leu Gln Val Gly Ser  Gly Ile Lys 
    1325                 1330                 1335             


Leu Asp  Lys Asp Thr Gln Ile  Val Tyr Gln Ser Pro  Ser Gly Leu 
    1340                 1345                 1350             


Phe Lys  Arg Arg Ile Pro Leu  Ala Asp Leu 
    1355                 1360             


<210> 296
<211> 1361
<212> PRT
<213> Lactobacillus rhamnosus


<220>
<223> Lactobacillus rhamnosus HN001

<400> 296
Met Thr Lys Leu Asn Gln Pro Tyr Gly Ile Gly Leu Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Val Val Asp Ala Asn Ser His Leu Leu Arg 
            20                  25                  30          


Leu Lys Gly Glu Thr Ala Ile Gly Ala Arg Leu Phe Arg Glu Gly Gln 
        35                  40                  45              


Ser Ala Ala Glu Arg Arg Glu Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Thr Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Ala Pro His 
65                  70                  75                  80  


Ile Thr Lys Ile Asp Pro Asp Phe Phe Leu Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Asp Arg Phe Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Glu Asp Tyr Pro Ser Met Tyr 
        115                 120                 125             


His Leu Arg Leu His Leu Met Thr His Thr His Lys Ala Asp Pro Arg 
    130                 135                 140                 


Glu Ile Phe Leu Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Pro Gly Ala Ala Lys Asp Phe Asn Thr Asp Lys Val Asp Leu 
                165                 170                 175     


Glu Asp Ile Phe Pro Ala Leu Thr Glu Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Glu Leu Thr Phe Asp Leu Ala Lys Ala Asp Asp Phe Lys Ala 
        195                 200                 205             


Lys Leu Leu Asp Glu Gln Ala Thr Pro Ser Asp Thr Gln Lys Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ser Ser Asp Gly Glu Lys Glu Ile Val Lys Lys 
225                 230                 235                 240 


Arg Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Ile Thr Gly Leu Lys 
                245                 250                 255     


Thr Lys Phe Asn Leu Ala Leu Gly Thr Glu Val Asp Glu Ala Asp Ala 
            260                 265                 270         


Ser Asn Trp Gln Phe Ser Met Gly Gln Leu Asp Asp Lys Trp Ser Asn 
        275                 280                 285             


Ile Glu Thr Ser Met Thr Asp Gln Gly Thr Glu Ile Phe Glu Gln Ile 
    290                 295                 300                 


Gln Glu His Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Met Ser Leu Ser Gln Ala Lys Val Ala Asp Tyr Gly Gln His Lys Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Thr Tyr Leu Lys Lys Leu Asn Asp His Glu 
            340                 345                 350         


Leu Ala Lys Thr Ile Arg Gly Leu Tyr Asp Arg Tyr Ile Asn Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Leu Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Glu Val Ser Glu Gln Leu Leu Asn Arg 
385                 390                 395                 400 


Met Gly Gln Ala Asn Phe Met Leu Lys Gln Arg Thr Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Val Gln Leu Gln Gln Arg Glu Leu Asp Gln Ile Ile Ala 
            420                 425                 430         


Asn Gln Ser Lys Tyr Tyr Asp Trp Leu Ala Lys Pro Asn Pro Val Glu 
        435                 440                 445             


Lys His Arg Ala Ser Lys Pro Tyr Gln Leu Asp Glu Leu Leu Thr Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ile Thr Pro Lys Glu Gln Ala 
465                 470                 475                 480 


Glu Ser Arg Glu Asn Val Phe Ala Trp Met Ile Arg Lys Asp Pro Ser 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Cys Pro Ala 
            500                 505                 510         


Ser Ala Asn Met Phe Ile Gln Arg Met Lys Asn Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Arg Ser Leu Leu Tyr Gln Lys Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Ser Ile Asp Gly Arg Arg Leu 
545                 550                 555                 560 


Gly Ala Asp Gln Lys Gln Arg Leu Ile Arg Glu Val Phe Glu Arg His 
                565                 570                 575     


Ser Ser Val Thr Ile Lys Gln Val Ala Glu Asn Leu Val Ala His Gly 
            580                 585                 590         


Asp Phe Ala Lys Arg Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr His Gln Leu Lys Lys Ile Leu His 
    610                 615                 620                 


Glu Ala Ile Asp Asp Pro Thr Lys Glu His Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Thr Trp Ser Thr Val Phe Glu Asp Ala Ala Ile Phe Lys Thr Glu Leu 
                645                 650                 655     


Ala Lys Ile Ser Trp Leu Asp Ser Asp Thr Ile Lys Ala Leu Ser Asn 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser Arg Lys Leu Leu Asp Gly 
        675                 680                 685             


Leu Lys Leu Gly Asn Gly His Thr Val Ile Gln Glu Leu Met Leu Ser 
    690                 695                 700                 


Asn His Asn Leu Met Gln Ile Leu Thr Asp Glu Thr Leu Lys Thr Thr 
705                 710                 715                 720 


Met Ala Glu Leu Asn Gln Asp Lys Leu Lys Ala Asp Asp Ile Glu Asp 
                725                 730                 735     


Val Ile Asn Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Arg Val Val Glu Asp Ile Lys His Ala Ala Asn Gly Gln 
        755                 760                 765             


Asp Pro Ser Trp Leu Tyr Ile Glu Thr Ala Asp Gly Pro Gly Thr Ala 
    770                 775                 780                 


Gly Lys Arg Thr Gln Ser Arg Gln Lys Gln Ile Gln Thr Val Tyr Ala 
785                 790                 795                 800 


Asn Ala Ala Gln Glu Leu Ile Asp Ser Ala Val Arg Gly Glu Leu Glu 
                805                 810                 815     


Asp Lys Ile Ala Asp Lys Ala Ser Phe Thr Asp Arg Leu Val Leu Tyr 
            820                 825                 830         


Phe Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Ala Pro Leu Asn Ile 
        835                 840                 845             


Asp Gln Leu Ser His Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu 
    850                 855                 860                 


Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Val Asn Ala Thr Ile 
865                 870                 875                 880 


Asn Arg Glu Lys Asn Asn Val Phe Ala Ser Thr Leu Phe Ala Ser Lys 
                885                 890                 895     


Met Ala Ala Thr Trp Arg Lys Trp His Glu Ala Gly Leu Ile Ser Gly 
            900                 905                 910         


Arg Lys Leu Arg Asn Leu Met Leu Arg Pro Asp Glu Ile Asp Lys Phe 
        915                 920                 925             


Ala His Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile 
    930                 935                 940                 


Lys Leu Thr Glu Gln Ile Ala Ala Ala Gln Tyr Pro Asn Thr Lys Ile 
945                 950                 955                 960 


Ile Ala Val Lys Ala Gly Leu Ser His Gln Leu Arg Glu Glu Leu Asp 
                965                 970                 975     


Phe Pro Lys Asn Arg Asp Val Asn His Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Phe Leu Ala Ala Arg Ile Gly Thr  Tyr Leu Leu Lys Arg  Tyr Pro Lys 
        995                 1000                 1005             


Leu Ala  Pro Phe Phe Thr Tyr  Gly Glu Phe Ala Lys  Val Asp Val 
    1010                 1015                 1020             


Lys Lys  Phe Arg Glu Phe Asn  Phe Ile Gly Ala Leu  Thr His Ala 
    1025                 1030                 1035             


Lys Lys  Asn Ile Val Ala Lys  Asp Thr Gly Glu Ile  Val Trp Asp 
    1040                 1045                 1050             


Lys Glu  Arg Asp Ile Gln Glu  Leu Asp Arg Ile Tyr  Asn Phe Lys 
    1055                 1060                 1065             


Arg Met  Leu Ile Thr His Glu  Val Tyr Phe Glu Thr  Ala Asp Leu 
    1070                 1075                 1080             


Phe Lys  Gln Thr Ile Tyr Ala  Ala Lys Asp Ser Lys  Glu Arg Gly 
    1085                 1090                 1095             


Gly Ser  Lys Gln Leu Ile Pro  Lys Lys Gln Gly Tyr  Pro Thr Gln 
    1100                 1105                 1110             


Val Tyr  Gly Gly Tyr Thr Arg  Glu Asn Thr Ala Tyr  Leu Ala Val 
    1115                 1120                 1125             


Val Lys  Thr Val Glu Lys Lys  Ala Asp Val Tyr Arg  Val Val Arg 
    1130                 1135                 1140             


Ile Ala  Thr Ser Gln Val Ala  Ala Leu Lys Glu Ala  Arg Ala Gln 
    1145                 1150                 1155             


Ser Thr  Val Lys Glu Arg Glu  Leu Leu Lys Lys Phe  Leu Thr Thr 
    1160                 1165                 1170             


Lys Phe  Thr Lys Ile Gly Lys  Asn Gly Lys Lys Ala  Ile Thr Pro 
    1175                 1180                 1185             


Phe Asp  Ile Val Ile Pro Arg  Val Pro Arg Glu Gln  Leu Phe His 
    1190                 1195                 1200             


Asn Lys  Arg Tyr Gly Phe Phe  Met Val Asn Ser Asp  Thr Leu Met 
    1205                 1210                 1215             


His Asn  Tyr Gln Glu Leu Trp  Met Ser Arg Ser Asp  Gln Gln Ile 
    1220                 1225                 1230             


Leu Ser  Lys Leu Val Lys Ser  Ala Lys Thr Val Glu  Asn Gly Gln 
    1235                 1240                 1245             


Val Gly  Arg Leu Phe Glu Asn  Ile Val Glu Gln Ile  Asn Lys Tyr 
    1250                 1255                 1260             


Phe Pro  Leu Tyr Asp Ile Asn  Gln Phe Arg Lys Lys  Leu Asp Gln 
    1265                 1270                 1275             


Ser Lys  Asp Ile Phe Ser Lys  Leu Pro Leu Glu Gly  Asn Gly Thr 
    1280                 1285                 1290             


Thr Ser  Gly Lys Arg Glu Thr  Ile Gln Asn Ile Leu  Thr Gly Ala 
    1295                 1300                 1305             


Gly Thr  Gly Ala Lys Asn Gly  Asp Leu Lys Asn Leu  Gly Ile Lys 
    1310                 1315                 1320             


Thr Pro  Phe Gly Phe Leu Gln  Val Pro Ser Gly Ile  Val Leu Asp 
    1325                 1330                 1335             


Asp Asp  Thr Thr Leu Ile Tyr  Gln Ser Pro Thr Gly  Met Leu Asn 
    1340                 1345                 1350             


Arg Ile  Val Arg Leu Ser Glu  Leu 
    1355                 1360     


<210> 297
<211> 1361
<212> PRT
<213> Lactobacillus rhamnosus


<220>
<223> Lactobacillus rhamnosus R0011

<400> 297
Met Thr Lys Leu Asn Gln Pro Tyr Gly Ile Gly Leu Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Val Val Asp Ala Asn Ser His Leu Leu Arg 
            20                  25                  30          


Leu Lys Gly Glu Thr Ala Ile Gly Ala Arg Leu Phe Arg Glu Gly Gln 
        35                  40                  45              


Ser Ala Ala Glu Arg Arg Glu Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Thr Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Ala Pro His 
65                  70                  75                  80  


Ile Thr Lys Ile Asp Pro Asp Phe Phe Leu Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Asp Arg Phe Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Glu Asp Tyr Pro Ser Met Tyr 
        115                 120                 125             


His Leu Arg Leu His Leu Met Thr His Thr His Lys Ala Asp Pro Arg 
    130                 135                 140                 


Glu Ile Phe Leu Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Pro Gly Ala Ala Lys Asp Phe Asn Thr Asp Lys Val Asp Leu 
                165                 170                 175     


Glu Asp Ile Phe Pro Ala Leu Thr Glu Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Glu Leu Thr Phe Asp Leu Ala Lys Ala Asp Asp Phe Lys Ala 
        195                 200                 205             


Lys Leu Leu Asp Glu Gln Ala Thr Pro Ser Asp Thr Gln Lys Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ser Ser Asp Gly Glu Lys Glu Ile Val Lys Lys 
225                 230                 235                 240 


Arg Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Ile Thr Gly Leu Lys 
                245                 250                 255     


Thr Lys Phe Asn Leu Ala Leu Gly Thr Glu Val Asp Glu Ala Asp Ala 
            260                 265                 270         


Ser Asn Trp Gln Phe Ser Met Gly Gln Leu Asp Asp Lys Trp Ser Asn 
        275                 280                 285             


Ile Glu Thr Ser Met Thr Asp Gln Gly Thr Glu Ile Phe Glu Gln Ile 
    290                 295                 300                 


Gln Glu Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Met Ser Leu Ser Gln Ala Lys Val Ala Asp Tyr Gly Gln His Lys Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Thr Tyr Leu Lys Lys Leu Asn Asp His Glu 
            340                 345                 350         


Leu Ala Lys Thr Ile Arg Gly Leu Tyr Asp Arg Tyr Ile Asn Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Leu Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Glu Val Ser Glu Gln Leu Leu Asn Arg 
385                 390                 395                 400 


Met Gly Gln Ala Asn Phe Met Leu Lys Gln Arg Thr Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Val Gln Leu Gln Gln Arg Glu Leu Asp Gln Ile Ile Ala 
            420                 425                 430         


Asn Gln Ser Lys Tyr Tyr Asp Trp Leu Ala Lys Pro Asn Pro Val Glu 
        435                 440                 445             


Lys His Arg Ala Ser Lys Pro Tyr Gln Leu Asp Glu Leu Leu Thr Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ile Thr Pro Lys Glu Gln Ala 
465                 470                 475                 480 


Glu Ser Arg Glu Asn Val Phe Ala Trp Met Ile Arg Lys Asp Pro Ser 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Cys Pro Ala 
            500                 505                 510         


Ser Ala Asn Met Phe Ile Gln Arg Met Lys Asn Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Arg Ser Leu Leu Tyr Gln Lys Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Ser Ile Asp Gly Arg Arg Leu 
545                 550                 555                 560 


Gly Ala Asp Gln Lys Gln Arg Leu Ile Arg Glu Val Phe Glu Arg His 
                565                 570                 575     


Ser Ser Val Thr Ile Lys Gln Val Ala Glu Asn Leu Val Ala His Gly 
            580                 585                 590         


Asp Phe Ala Lys Arg Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr His Gln Leu Lys Lys Ile Leu His 
    610                 615                 620                 


Glu Ala Ile Asp Asp Pro Thr Lys Glu His Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Thr Trp Ser Thr Val Phe Glu Asp Ala Ala Ile Phe Lys Thr Glu Leu 
                645                 650                 655     


Ala Lys Ile Ser Trp Leu Asp Ser Asp Thr Ile Lys Ala Leu Ser Asn 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser Arg Lys Leu Leu Asp Gly 
        675                 680                 685             


Leu Lys Leu Gly Asn Gly His Thr Val Ile Gln Glu Leu Met Leu Ser 
    690                 695                 700                 


Asn His Asn Leu Met Gln Ile Leu Thr Asp Glu Thr Leu Lys Thr Thr 
705                 710                 715                 720 


Met Ala Glu Leu Asn Gln Asp Lys Leu Lys Ala Asp Asp Ile Glu Asp 
                725                 730                 735     


Val Ile Asn Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Arg Val Val Glu Asp Ile Lys His Ala Ala Asn Gly Gln 
        755                 760                 765             


Asp Pro Ser Trp Leu Tyr Ile Glu Thr Ala Asp Gly Pro Gly Thr Ala 
    770                 775                 780                 


Gly Lys Arg Thr Gln Ser Arg Gln Lys Gln Ile Gln Thr Val Tyr Ala 
785                 790                 795                 800 


Asn Ala Ala Gln Glu Leu Ile Asp Ser Ala Val Arg Gly Glu Leu Glu 
                805                 810                 815     


Asp Lys Ile Ala Asp Lys Ala Ser Phe Thr Asp Arg Leu Val Leu Tyr 
            820                 825                 830         


Phe Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Ala Pro Leu Asn Ile 
        835                 840                 845             


Asp Gln Leu Ser His Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu 
    850                 855                 860                 


Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Val Asn Ala Thr Ile 
865                 870                 875                 880 


Asn Arg Glu Lys Asn Asn Val Phe Ala Ser Thr Leu Phe Ala Ser Lys 
                885                 890                 895     


Met Ala Ala Thr Trp Arg Lys Trp His Glu Ala Gly Leu Ile Ser Gly 
            900                 905                 910         


Arg Lys Leu Arg Asn Leu Met Leu Arg Pro Asp Glu Ile Asp Lys Phe 
        915                 920                 925             


Ala His Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile 
    930                 935                 940                 


Lys Leu Thr Glu Gln Ile Ala Ala Ala Gln Tyr Pro Asn Thr Lys Ile 
945                 950                 955                 960 


Ile Ala Val Lys Ala Gly Leu Ser His Gln Leu Arg Glu Glu Leu Asp 
                965                 970                 975     


Phe Pro Lys Asn Arg Asp Val Asn His Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Phe Leu Ala Ala Arg Ile Gly Thr  Tyr Leu Leu Lys Arg  Tyr Pro Lys 
        995                 1000                 1005             


Leu Ala  Pro Phe Phe Thr Tyr  Gly Glu Phe Ala Lys  Val Asp Val 
    1010                 1015                 1020             


Lys Lys  Phe Arg Glu Phe Asn  Phe Ile Gly Ala Leu  Thr His Ala 
    1025                 1030                 1035             


Lys Lys  Asn Ile Val Ala Lys  Asp Thr Gly Glu Ile  Val Trp Asp 
    1040                 1045                 1050             


Lys Glu  Arg Asp Ile Gln Glu  Leu Asp Arg Ile Tyr  Asn Phe Lys 
    1055                 1060                 1065             


Arg Met  Leu Ile Thr His Glu  Val Tyr Phe Glu Thr  Ala Asp Leu 
    1070                 1075                 1080             


Phe Lys  Gln Thr Ile Tyr Ala  Ala Lys Asp Ser Lys  Glu Arg Gly 
    1085                 1090                 1095             


Gly Ser  Lys Gln Leu Ile Pro  Lys Lys Gln Gly Tyr  Pro Thr Gln 
    1100                 1105                 1110             


Val Tyr  Gly Gly Tyr Thr Arg  Glu Asn Thr Ala Tyr  Leu Ala Val 
    1115                 1120                 1125             


Val Lys  Thr Val Glu Lys Lys  Ala Asp Val Tyr Arg  Val Val Arg 
    1130                 1135                 1140             


Ile Ala  Thr Ser Gln Val Ala  Ala Leu Lys Glu Ala  Arg Ala Gln 
    1145                 1150                 1155             


Ser Thr  Val Lys Glu Arg Glu  Leu Leu Lys Lys Phe  Leu Thr Thr 
    1160                 1165                 1170             


Lys Phe  Thr Lys Ile Gly Lys  Asn Gly Lys Lys Ala  Ile Thr Pro 
    1175                 1180                 1185             


Phe Asp  Ile Val Ile Pro Arg  Val Pro Arg Glu Gln  Leu Phe His 
    1190                 1195                 1200             


Asn Lys  Arg Tyr Gly Phe Phe  Met Val Asn Ser Asp  Thr Leu Met 
    1205                 1210                 1215             


His Asn  Tyr Gln Glu Leu Trp  Met Ser Arg Ser Asp  Gln Gln Ile 
    1220                 1225                 1230             


Leu Ser  Lys Leu Val Lys Ser  Ala Lys Thr Val Glu  Asn Gly Gln 
    1235                 1240                 1245             


Val Gly  Arg Leu Phe Glu Asn  Ile Val Glu Gln Ile  Asn Lys Tyr 
    1250                 1255                 1260             


Phe Pro  Leu Tyr Asp Ile Asn  Gln Phe Arg Lys Lys  Leu Asp Gln 
    1265                 1270                 1275             


Ser Lys  Asp Ile Phe Ser Lys  Leu Pro Leu Glu Gly  Asn Gly Thr 
    1280                 1285                 1290             


Thr Ser  Gly Lys Arg Glu Thr  Ile Gln Asn Ile Leu  Thr Gly Ala 
    1295                 1300                 1305             


Gly Thr  Gly Ala Lys Asn Gly  Asp Leu Lys Asn Leu  Gly Ile Lys 
    1310                 1315                 1320             


Thr Pro  Phe Gly Phe Leu Gln  Val Pro Ser Gly Ile  Val Leu Asp 
    1325                 1330                 1335             


Asp Asp  Thr Thr Leu Ile Tyr  Gln Ser Pro Thr Gly  Met Leu Asn 
    1340                 1345                 1350             


Arg Ile  Val Arg Leu Ser Glu  Leu 
    1355                 1360     


<210> 298
<211> 1375
<212> PRT
<213> Lactobacillus ruminis


<220>
<223> Lactobacillus ruminis ATCC 25644

<400> 298
Met Arg Lys Asn Gln Glu Pro Tyr Asn Ile Gly Leu Asp Ile Gly Thr 
1               5                   10                  15      


Ser Ser Ile Gly Trp Ser Ile Met Asn Asp Asn Phe Asp Leu Met Arg 
            20                  25                  30          


Val Lys Gly Lys Lys Gly Ile Gly Val Arg Leu Tyr Asn Glu Gly Gln 
        35                  40                  45              


Ser Ala Ala Glu Arg Arg Met His Arg Thr Ala Arg Arg Arg Tyr Gly 
    50                  55                  60                  


Arg Arg Lys Trp Arg Leu Arg Leu Leu Glu Asp Phe Phe Asp Glu His 
65                  70                  75                  80  


Met Ala Glu Val Asp Asp Thr Phe Phe Ala Arg Leu Lys Asp Ser Asn 
                85                  90                  95      


Ile Ser Pro Lys Asp Asp Lys Lys Tyr Arg Lys Ser Leu Leu Phe Pro 
            100                 105                 110         


Lys Ser Lys Gly Val Thr Tyr Gln Asp Asp Gly Glu Phe Tyr Lys Lys 
        115                 120                 125             


Tyr Pro Thr Met Tyr His Leu Arg Tyr Ala Leu Met Thr Glu His Arg 
    130                 135                 140                 


Lys Phe Asp Leu Arg Glu Ile Tyr Leu Ala Phe His His Met Val Lys 
145                 150                 155                 160 


Tyr Arg Gly Asn Phe Leu Tyr Asp Thr Ser Val Asp Ser Phe Glu Ala 
                165                 170                 175     


Lys Asn Leu Asp Ile Lys Gly Lys Phe Asp Glu Ile Asn Asp Leu Leu 
            180                 185                 190         


Ser Ser Tyr Thr Asp Phe Tyr Val Asp Asn Ser Asn Ala Ala Leu Val 
        195                 200                 205             


Glu Ser Ile Leu Leu Glu Lys Asn Thr Thr Arg Lys Asp Lys Ser Lys 
    210                 215                 220                 


Lys Ile Ala Lys Leu Leu His Val Glu Asp Lys Glu Lys Gly Lys Asn 
225                 230                 235                 240 


Lys Lys Ala Lys Asp Leu Ala Thr Gln Ile Ser Asn Ala Val Leu Gly 
                245                 250                 255     


Leu Lys Cys Asn Phe His Leu Ile Phe Glu Leu Gln Gln Lys Tyr Ser 
            260                 265                 270         


Phe Asp Leu Cys Ser Glu Lys Thr Glu Glu Asn Ile Ala Lys Leu Ser 
        275                 280                 285             


Glu Val Leu Asp Glu Asn Gln Lys Met Leu Leu Met Ile Leu Lys Glu 
    290                 295                 300                 


Val Gln Asp Gln Val Met Leu Asn Ala Phe Val Pro Ser Gly Met Ser 
305                 310                 315                 320 


Leu Ser Glu Ala Met Met Gln Lys Tyr Asp Asp Tyr Gly Glu Gln Leu 
                325                 330                 335     


Lys Ile Tyr His Glu Leu Glu His Ser Val Ser Asp Asp Ser Ala Ala 
            340                 345                 350         


Lys Leu Arg Gly Ala Tyr Arg Asp Tyr Asn Asp Asn Ile Ile Lys Arg 
        355                 360                 365             


Ile Asp Gly Asp Asn Lys Lys Asp Thr Phe Tyr Lys Arg Val Lys Asn 
    370                 375                 380                 


Ile Leu Thr Lys Ile Ser Lys Glu Tyr Val Asp Gln Asp Val Leu Glu 
385                 390                 395                 400 


Ser Cys Gly Lys Leu Lys Lys Leu Ile Asp Glu Asn Lys Leu Phe Ile 
                405                 410                 415     


Arg Gln Arg Thr Ala Ala Asn Gly Val Leu Pro His Gln Leu His Gln 
            420                 425                 430         


Ile Glu Met Arg Lys Ile Ile Asp Asn Gln Lys Glu Tyr Tyr Pro Trp 
        435                 440                 445             


Leu Ala Glu Pro Asn Pro Asn Glu Lys Arg Arg Val Tyr Ser Lys Tyr 
    450                 455                 460                 


Lys Val Glu Glu Leu Ile Ala Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
465                 470                 475                 480 


Leu Val Asp Pro Asn Asn Ala Asp Lys Asn Lys Glu Ala Arg Phe Ser 
                485                 490                 495     


Trp Met Val Arg Lys Lys Asp Gly Glu Ile Thr Pro Trp Asn Phe Tyr 
            500                 505                 510         


Asp Lys Val Asp Trp Ala Glu Ser Ala Asn Asn Phe Ile Glu Arg Met 
        515                 520                 525             


Lys Ser Lys Asp Thr Tyr Leu Leu Gly Glu Asp Val Val Pro Lys Glu 
    530                 535                 540                 


Ser Met Leu Tyr Gln Lys Tyr Glu Val Leu Asn Glu Leu Asn Asn Leu 
545                 550                 555                 560 


Arg Ile Asn Asp Ser Gly Leu Ser Asp Ser Phe Glu Asp Val Lys Leu 
                565                 570                 575     


Lys Gln Ala Ile Tyr Asn Asp Leu Phe Lys Lys Gln Lys Ile Val Lys 
            580                 585                 590         


Ile Thr Asp Leu Gln Asn Tyr Leu Val Gln Asn His Lys Tyr Leu Val 
        595                 600                 605             


Lys Pro Lys Ile Ser Gly Leu Ala Asp Glu Asn Arg Phe Leu Ser Ser 
    610                 615                 620                 


Leu Ser Thr Tyr Ser Asp Leu Lys Thr Ile Phe Gly Asp Lys Val Asp 
625                 630                 635                 640 


Asp Arg Thr Tyr Phe Asn Asp Phe Glu Lys Met Val Glu Tyr Ser Thr 
                645                 650                 655     


Val Phe Glu Asp Gly His Asp Tyr Asn Gln Lys Leu Asp Glu Tyr Thr 
            660                 665                 670         


Trp Leu Thr Lys Glu Glu Lys Tyr Lys Ile Gly Lys Lys Arg Tyr Arg 
        675                 680                 685             


Gly Trp Gly Lys Leu Ser Lys Lys Leu Leu Thr Gly Leu Arg Asp Lys 
    690                 695                 700                 


Asn Asn His Thr Ile Met Asp Asn Leu Trp Glu Thr Asn Arg Asn Phe 
705                 710                 715                 720 


Met Gln Ile Gln Thr Ala Asp Glu Phe Ser Lys Gln Ile Ala Glu Glu 
                725                 730                 735     


Asn Glu Arg His Leu Lys Gly Ser Val Ser Asp Ala Ile Asn Asp Met 
            740                 745                 750         


Tyr Thr Ser Pro Ala Asn Lys Lys Ala Ile Arg Gln Val Leu Arg Val 
        755                 760                 765             


Val Asp Asp Ile Gln Lys Ala Met Gly Tyr Ala Pro Ser Ser Ile Ser 
    770                 775                 780                 


Leu Glu Phe Ala Arg Glu Asp Gly Pro Ser Val Arg Thr Val Ser Arg 
785                 790                 795                 800 


Ala Asn Arg Met Lys Ser Ile Tyr Glu Lys Tyr Ala Ser Glu Val Ser 
                805                 810                 815     


Glu Glu Val Met Lys Asp Leu Asp Gly Val Ile Lys Asp Lys Lys Gly 
            820                 825                 830         


Leu Asn Asp Arg Leu Tyr Leu Tyr Phe Glu Gln Gln Gly Lys Asp Met 
        835                 840                 845             


Tyr Ser Gly His Pro Leu Asp Phe Asp Lys Val Ile Ser Gly Gln Glu 
    850                 855                 860                 


Tyr Asp Ile Asp His Ile Leu Pro Gln Ala Val Ile Lys Asp Asp Ser 
865                 870                 875                 880 


Leu Asp Asn Arg Val Leu Thr Thr Lys Ala Leu Asn Asn Asp Val Lys 
                885                 890                 895     


Ser Lys Gly Val Pro Cys Arg Met Phe Asn Gly Met His Ser Phe Trp 
            900                 905                 910         


Lys Asn Leu Tyr Asp Lys Gly Phe Ile Ser Arg Arg Lys Phe Asn Asn 
        915                 920                 925             


Leu Thr Thr Asn Pro Glu Asn Ile Asp Lys Tyr Lys Met Lys Gly Phe 
    930                 935                 940                 


Val Asn Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Lys Leu Val Ala 
945                 950                 955                 960 


Asn Val Leu Asn Asp Lys Tyr Gln Asn Asp Asp Val Asp Ile Ile Glu 
                965                 970                 975     


Val Arg Ala Glu Leu Thr His Asp Val Arg Lys His Phe Lys Phe Tyr 
            980                 985                 990         


Lys Asn Arg Asn Val Asn Asp Tyr  His His Ala Phe Asp  Ala Tyr Leu 
        995                 1000                 1005             


Thr Ser  Phe Ile Gly His Tyr  Leu Phe Lys Lys Tyr  Pro Asn Leu 
    1010                 1015                 1020             


Arg Pro  Leu Phe Asp Tyr Asn  Asp Phe Met Lys Val  Ser Asp Asn 
    1025                 1030                 1035             


Val Phe  Lys Gln Leu Arg Gly  Asn Asn Phe Leu Gly  Glu Phe Leu 
    1040                 1045                 1050             


Asn Lys  Thr Gly Asp Ile Ile  Ser Thr Asp Gly Asn  Phe Val Leu 
    1055                 1060                 1065             


Asn Lys  Glu Glu Met Ile Asn  Lys Leu Asn Lys Ala  Tyr Ala Phe 
    1070                 1075                 1080             


Lys Lys  Ile Leu Val Thr Lys  Glu Val Gly Gln Arg  Thr Gly Ala 
    1085                 1090                 1095             


Met Phe  Asn Glu Thr Arg Tyr  Pro Ala Pro Asn Ser  Arg Lys Ala 
    1100                 1105                 1110             


Ala Leu  Lys Tyr Arg Arg Met  Pro Lys Pro Asp Ser  Leu Ile Ser 
    1115                 1120                 1125             


Val Lys  Asp Tyr Lys Asn Thr  Asp Ile Tyr Gly Gly  Tyr Ser Gly 
    1130                 1135                 1140             


Lys Asn  Asp Ala Tyr Met Val  Ile Val Asp Met Gly  Lys Gln Tyr 
    1145                 1150                 1155             


Met Val  Val Gly Val Pro Val  Arg Tyr Thr Glu Lys  Leu Asp Lys 
    1160                 1165                 1170             


Leu Arg  Ile Lys His Ser Glu  Leu Tyr Arg Asp Glu  Leu Arg Lys 
    1175                 1180                 1185             


Val Leu  Ser Arg Asp Lys Thr  Leu Leu Asp Ser Lys  Gly Asn Val 
    1190                 1195                 1200             


Lys Arg  Phe Asp Ile Val Leu  Asp Arg Val Leu Tyr  Gly Gln Leu 
    1205                 1210                 1215             


Ile Glu  Asp Gly Asn Glu Leu  Phe Thr Leu Gly Ser  Ser Lys Tyr 
    1220                 1225                 1230             


Lys Arg  Asn Phe Arg Gln Leu  Phe Leu Asp Lys Gln  Cys Ile Glu 
    1235                 1240                 1245             


Ile Leu  Asp Ser Ser Ala Thr  Pro Gln Pro Thr Asp  Glu Glu Leu 
    1250                 1255                 1260             


Ile Trp  Val Tyr Asp Gln Ile  Leu Asp Lys Val Asp  Lys Tyr Phe 
    1265                 1270                 1275             


Glu Leu  Tyr Asp Ile Asn Arg  Gln Arg Glu Thr Leu  Arg Lys Gly 
    1280                 1285                 1290             


Arg Ala  Ala Phe Cys Ser Leu  Pro Asn Ile Ser Met  Lys Lys Asp 
    1295                 1300                 1305             


Asp Val  Thr Lys Lys Lys Ile  Leu Asn Glu Ile Leu  Val Ala Leu 
    1310                 1315                 1320             


His Ala  Asn Glu Ser Glu Ser  Asn Cys Glu Lys Ile  Gly Lys Lys 
    1325                 1330                 1335             


Val Phe  Gly Arg Leu Gln Val  Pro Gly Gly Ile Lys  Leu Ser Lys 
    1340                 1345                 1350             


Glu Ala  Lys Leu Ile Tyr Gln  Ser Pro Thr Gly Leu  Phe Glu Arg 
    1355                 1360                 1365             


Val Val  Tyr Leu Lys Asp Leu  
    1370                 1375 


<210> 299
<211> 1339
<212> PRT
<213> Lactobacillus salivarius


<220>
<223> Lactobacillus salivarius SMXD51

<400> 299
Met Glu Arg Tyr His Ile Gly Leu Asp Ile Gly Thr Ser Ser Ile Gly 
1               5                   10                  15      


Trp Ala Val Ile Gly Asp Asp Phe Lys Ile Lys Lys Lys Lys Gly Lys 
            20                  25                  30          


Asn Leu Ile Gly Thr Arg Leu Phe Asn Glu Gly Ala Thr Ala Ala Glu 
        35                  40                  45              


Arg Arg Gly Phe Arg Thr Gln Arg Arg Arg Leu Asn Arg Arg Lys Trp 
    50                  55                  60                  


Arg Leu Lys Leu Leu Glu Glu Ile Phe Asp Pro Tyr Met Ala Glu Val 
65                  70                  75                  80  


Asp Glu Tyr Phe Phe Ala Arg Leu Lys Ser Ser Asn Leu Ser Pro Lys 
                85                  90                  95      


Asp Ser Asn Lys Lys Tyr Leu Gly Ser Leu Leu Phe Pro Asp Lys Ser 
            100                 105                 110         


Asp Ser Asn Phe Tyr Asp Lys Tyr Pro Thr Ile Tyr His Leu Arg Arg 
        115                 120                 125             


Asp Leu Met Glu Lys Asp Glu Lys Phe Asp Leu Arg Glu Ile Tyr Leu 
    130                 135                 140                 


Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Glu Lys Val 
145                 150                 155                 160 


Pro Ala Lys Asn Tyr Lys Asn Ser Gly Ala Ser Ile Gly Phe Leu Leu 
                165                 170                 175     


Glu Glu Val Asn Ser Leu Tyr Lys Asp Ile Ile Gly Asp Glu Ser Ile 
            180                 185                 190         


Ala Ile Leu Asn Ser Glu Lys Phe Glu Asp Val Glu Lys Ile Ile Leu 
        195                 200                 205             


Asp Glu Glu Thr Arg Asn Leu Asp Lys Gln Lys Ser Val Gly Lys Leu 
    210                 215                 220                 


Leu Val Glu Asp Lys Lys Lys Lys Asn Ile Val Thr Ala Phe Ser Lys 
225                 230                 235                 240 


Ala Ile Phe Gly Tyr Lys Phe Asn Ile Glu Asp Leu Leu Leu Ile Glu 
                245                 250                 255     


Asn Asp Glu Lys Asn Lys Leu Thr Phe Asn Asp Glu Asn Ile Asp Asp 
            260                 265                 270         


Ile Phe Asn Glu Leu Ser His Ser Leu Asp Asp Lys Gln Met Asp Leu 
        275                 280                 285             


Leu Thr Lys Thr Arg Glu Ile Tyr Phe Lys Phe Lys Leu Asn Met Ile 
    290                 295                 300                 


Val Pro Thr Gly Tyr Thr Leu Ser Glu Ser Met Ile Glu Lys Tyr Glu 
305                 310                 315                 320 


Met His Lys Ala His Leu Lys Met Tyr Lys Glu Phe Ile Asn Thr Leu 
                325                 330                 335     


Asn Thr Lys Asp Arg Lys Ile Leu Lys Asn Ala Tyr Ser Asp Tyr Ile 
            340                 345                 350         


Asn Thr Glu Lys Ala Lys Ala Ala Asn Ala Gln Glu Asn Phe Tyr Lys 
        355                 360                 365             


Thr Val Lys Lys Ile Ile Lys Asp Asn Asn Ser Asp Thr Ala Lys Lys 
    370                 375                 380                 


Ile Ile Val Leu Ile Asp Glu Gly Asn Phe Met Pro Lys Gln Arg Thr 
385                 390                 395                 400 


Gly Glu Asn Gly Val Ile Pro His Gln Leu His Gln Ile Glu Leu Asp 
                405                 410                 415     


Arg Ile Ile Glu Asn Gln Ala Lys Tyr Tyr Pro Trp Leu Ala Glu Ala 
            420                 425                 430         


Asn Pro Val Glu Lys Asn Arg Lys Phe Ala Lys Tyr Lys Leu Asp Glu 
        435                 440                 445             


Leu Val Thr Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Ile Asp Lys 
    450                 455                 460                 


Thr Glu Ser Asn Lys Asn Glu Lys Glu Thr Lys Phe Ala Trp Met Val 
465                 470                 475                 480 


Arg Lys Ala Lys Gly Thr Ile Thr Pro Trp Asn Phe Glu Asn Leu Val 
                485                 490                 495     


Asp Arg Thr Glu Ser Ala Asn Arg Phe Ile Lys Arg Met Thr Ser Lys 
            500                 505                 510         


Asp Thr Tyr Ile Ile Gly Glu Asp Val Leu Pro Ala Ser Ser Leu Leu 
        515                 520                 525             


Tyr Glu Lys Phe Lys Val Leu Asn Glu Leu Asn Asn Ile Lys Val Asn 
    530                 535                 540                 


Glu Lys Lys Leu Asp Ile Glu Gln Lys Gln Asp Ile Tyr Leu Asn Leu 
545                 550                 555                 560 


Phe Thr Thr Ala Lys Asn Val Thr Lys Lys Ser Leu Ala Thr Tyr Leu 
                565                 570                 575     


Asn Cys Ser Ala Asp Ser Ile Ser Gly Leu Ser Asp Gly Glu Lys Phe 
            580                 585                 590         


Asn Ser Ser Leu Ser Ser Tyr Ile Asp Leu Lys Ala Ile Leu Gly Asn 
        595                 600                 605             


Ile Val Asp Asp Cys Asn Lys Asn Glu Asp Leu Glu Lys Ile Ile Glu 
    610                 615                 620                 


Tyr Ser Thr Val Phe Glu Asp Gly Asn Ile Tyr Lys Glu Lys Leu Ser 
625                 630                 635                 640 


Glu Ile Ser Trp Leu Thr Asp Glu Gln Ile Glu Lys Leu Ser Asn Ile 
                645                 650                 655     


His Phe Lys Gly Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Gln Ile 
            660                 665                 670         


Thr Asn Glu Asn Gly Glu Arg Ile Ile Asp Ala Leu Trp Asn Thr Ser 
        675                 680                 685             


Asn Asn Phe Met Gln Ile Ile Asn Asp Glu Ser Ile Gln Ala Lys Leu 
    690                 695                 700                 


Ala Glu Ile Asn Gly Lys Tyr Ala Gly Lys Ser Asp Leu Glu Asp Ile 
705                 710                 715                 720 


Leu Ser Glu Ala Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile Arg Gln 
                725                 730                 735     


Val Met Lys Val Val Glu Asp Ile Glu Lys Ala Met Gln Cys Glu Pro 
            740                 745                 750         


Thr Ser Ile Ser Ile Glu Phe Thr Arg Lys Lys Gln Lys Ser Arg Leu 
        755                 760                 765             


Thr Asn Thr Arg Tyr Lys Lys Ile Ser Asp Val Tyr Glu Lys Ile Ala 
    770                 775                 780                 


Asp Glu Val Ile Ser Glu Tyr Glu Leu Arg Lys Leu Gln Ser Glu Leu 
785                 790                 795                 800 


Asp Ser Asn Ala Asn Asn Met Arg Asp Arg Tyr Tyr Leu Tyr Phe Met 
                805                 810                 815     


Gln Leu Gly Arg Asp Met Tyr Thr Gly Glu Lys Ile Asn Ile Asp Glu 
            820                 825                 830         


Leu His Gln Arg Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Phe Ile 
        835                 840                 845             


Lys Asp Asp Ser Ile Asn Asn Arg Val Leu Thr Arg Lys Asp Val Asn 
    850                 855                 860                 


Asn Lys Glu Lys Ser Asp Lys Thr Ala Ala Asp Leu Tyr Ala Val Glu 
865                 870                 875                 880 


Met Ser Asp Phe Trp Arg Lys Leu Arg Lys Gln Gly Leu Ile Thr Glu 
                885                 890                 895     


Gln Lys Tyr Lys Asn Leu Leu Thr Lys Ser Asp Ser Ile Asp Lys Tyr 
            900                 905                 910         


Ala Lys Lys Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Ser Gln Val 
        915                 920                 925             


Val Lys Leu Val Ala Asn Ile Leu Gln Asp Lys Tyr Ser Asp Thr Lys 
    930                 935                 940                 


Ile Ile Glu Val Arg Ala Lys Leu Asn Ser Asn Leu Arg Glu Glu Tyr 
945                 950                 955                 960 


Lys Leu Ile Lys Asn Arg Ala Val Asn Asp Tyr His His Ala Ile Asp 
                965                 970                 975     


Gly Tyr Leu Thr Thr Phe Ile Gly Gln Tyr Leu Tyr Lys Thr Tyr Pro 
            980                 985                 990         


Lys Leu Arg Ser Tyr Phe Val Tyr  Asn Asp Phe Lys Lys  Leu Asp Ser 
        995                 1000                 1005             


Asn Tyr  Leu Lys His Met Lys  Lys Phe Asn Phe Leu  Trp Gln Leu 
    1010                 1015                 1020             


Gln Asp  Asp Lys Thr Ile Asp  Ile Tyr Asp Asn Val  Asn Asn Lys 
    1025                 1030                 1035             


Phe Val  Leu Asn Val Pro Glu  Met Lys Lys Tyr Ile  Gln Lys Ile 
    1040                 1045                 1050             


Tyr Asn  Tyr Lys Tyr Met Leu  Val Ser Lys Glu Val  Thr Thr Lys 
    1055                 1060                 1065             


Asn Gly  Ala Phe Tyr Asp Gln  Thr Lys Tyr Asn Ala  Lys Thr Val 
    1070                 1075                 1080             


Asn Leu  Ile Pro Ile Lys Lys  Asn Lys Pro Thr Asn  Ile Tyr Gly 
    1085                 1090                 1095             


Gly Tyr  Lys Gly Lys Val Ser  Ser Tyr Met Met Leu  Val Lys Ile 
    1100                 1105                 1110             


Arg Lys  Lys Lys Glu Val Ile  Tyr Lys Phe Val Gly  Val Pro Arg 
    1115                 1120                 1125             


Leu Trp  Thr Asp Glu Leu Asp  Arg Leu Lys Asp Thr  Thr Glu Arg 
    1130                 1135                 1140             


Lys Ile  Leu Leu Asn Glu Ile  Ala Lys Asn Ser Leu  Ser Lys Thr 
    1145                 1150                 1155             


Glu Gln  Asp Phe Glu Val Ile  Leu Asp Lys Val Tyr  Tyr Gly Gln 
    1160                 1165                 1170             


Leu Ile  Ile Asp Gly Asn Gln  Lys Tyr Thr Leu Gly  Ser Ser Glu 
    1175                 1180                 1185             


Tyr Lys  Tyr Asn Ala Met Gln  Leu His Leu Ser Lys  His Ala Leu 
    1190                 1195                 1200             


Glu Val  Leu Ala Lys Glu Asn  Val Lys Asp Ala Glu  Ile Thr Asp 
    1205                 1210                 1215             


Lys Asp  Leu Val Ser Val Tyr  Glu Glu Ile Leu Ser  Val Val Asn 
    1220                 1225                 1230             


Lys Tyr  Phe Glu Leu Tyr Asp  Ile Asn Lys Phe Arg  Gln Lys Leu 
    1235                 1240                 1245             


Asn Glu  Gly Leu Glu Ile Phe  Arg Lys Leu Pro Val  Tyr Asn Val 
    1250                 1255                 1260             


Tyr Glu  Ser Asn Lys Ile Lys  Gln Val Gly Lys Phe  Glu Val Leu 
    1265                 1270                 1275             


Asn Arg  Ile Leu Met Gly Leu  His Ala Asn Ala Met  Ile Thr Asp 
    1280                 1285                 1290             


Leu Lys  Val Leu Gly Ile Lys  Thr Lys Leu Gly Gln  Met Gln Val 
    1295                 1300                 1305             


Asn Gly  Gly Ile Lys Leu Ser  Pro Asp Ala Lys Leu  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Pro  Thr Gly Ile Phe Ser  Arg Ala Val Arg Val  Lys Asp Leu 
    1325                 1330                 1335             


Gly 
    


<210> 300
<211> 1331
<212> PRT
<213> Lactobacillus sanfranciscensis

<400> 300
Met Asn Lys Gln Pro Tyr Asn Ile Gly Leu Asp Ile Gly Thr Ser Ser 
1               5                   10                  15      


Val Gly Trp Ser Ala Thr Glu Leu Asp Asn Arg Leu Leu His Ile Lys 
            20                  25                  30          


Gly His Asn Gly Ile Gly Val Arg Leu Phe Lys Glu Gly Glu Ser Ala 
        35                  40                  45              


Ala Asp Arg Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Ala Arg Arg 
    50                  55                  60                  


Lys Trp Arg Leu Arg Leu Leu Asn Glu Ile Phe Ala Thr Glu Ile Ala 
65                  70                  75                  80  


Lys Val Asp Pro Ser Phe Phe Ala Arg Leu Lys Gln Ser Asn Val Ser 
                85                  90                  95      


Pro Lys Asp Pro Asn Lys Thr Met Phe Glu Asn Ile Leu Phe Asp Asp 
            100                 105                 110         


Glu Asn Leu Asp Asp Gln Lys Phe His His Asp Tyr Lys Thr Ile Tyr 
        115                 120                 125             


His Leu Arg Gln Ala Ile Ile Asn His Pro Glu Gln Lys Phe Asp Ile 
    130                 135                 140                 


Arg Leu Ile Tyr Leu Ala Met His His Ile Ile Lys Tyr Arg Gly His 
145                 150                 155                 160 


Phe Leu Asn Gln Ala Asn Val Gln Asp Phe Lys Gly Gly Lys Ile Asp 
                165                 170                 175     


Leu Glu Lys Ser Phe Lys Ala Leu Asn Asp Ile Phe Glu Asn Gln Gly 
            180                 185                 190         


Arg Asp Leu Arg Leu Val Thr Asp Lys Ala Asn Gln Tyr Val Lys Val 
        195                 200                 205             


Leu Ser Asp Asn Ala Lys Thr Arg Ser Asp Arg Lys Lys Glu Leu Ser 
    210                 215                 220                 


Lys Leu Leu Tyr Val Pro Ile Asp Lys Asp Thr Asp Lys Asn Ser Lys 
225                 230                 235                 240 


Lys Val Thr Gly Glu Ile Leu Lys Ala Ile Leu Gly Asn Lys Ala Lys 
                245                 250                 255     


Phe Asp Val Ile Phe Gly Ile Glu Val Glu Asn Pro Lys Glu Trp Val 
            260                 265                 270         


Leu Thr Phe Asn Ser Asp Asp Phe Asp Asp Lys Ile Glu Gly Leu Ser 
        275                 280                 285             


Ser Gln Met Thr Asp Glu Asp Ser Glu Ile Leu Leu Ile Leu Lys Glu 
    290                 295                 300                 


Leu Tyr Phe Ala Leu Asn Leu Ser Asp Ile Leu Asn Asn Ser Val Thr 
305                 310                 315                 320 


Asp Lys Asn Ala Lys Thr Leu Ser Glu Ala Met Ile Asn Arg Tyr Asp 
                325                 330                 335     


Asp His Lys Asn Gln Leu Ala Met Leu Lys Lys Val Ile Asp Ser Ser 
            340                 345                 350         


Asp Lys Lys His Ala Lys Glu Leu Lys Glu Ala Tyr Ser Ala Tyr Ile 
        355                 360                 365             


Asp Gly Glu Asn Asn Lys Lys Ile Ser Phe Glu Asp Leu Lys Lys Arg 
    370                 375                 380                 


Ile Gln Lys Asn Leu Val Asp Ser Glu Leu Ser Gln Lys Ile Asn Asp 
385                 390                 395                 400 


Leu Leu Asp His Asp Tyr Phe Leu Pro Lys Gln Arg Ser Lys Glu Asn 
                405                 410                 415     


Gly Ala Ile Pro His Gln Leu Gln Gln Gln Glu Leu Asp Gln Ile Ile 
            420                 425                 430         


Glu Ser Gln Lys Gln Tyr Tyr Pro Phe Leu Ala Glu Leu Asn Pro Asn 
        435                 440                 445             


Glu Lys Arg Ser Arg Gln Ala Lys Tyr Lys Leu Asp Glu Leu Val Ala 
    450                 455                 460                 


Phe Arg Val Pro Tyr Tyr Val Gly Pro Met Val Glu Val Thr Asp Ser 
465                 470                 475                 480 


Asn Gln Glu Asn Asn Gly Lys Phe Ala Trp Met Ile Arg Lys Glu Gln 
                485                 490                 495     


Gly Glu Ile Thr Pro Trp Asn Phe Asp Glu Lys Val Asp Arg Thr Glu 
            500                 505                 510         


Thr Ala Thr Lys Phe Ile Thr Arg Met Thr Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Pro Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe 
    530                 535                 540                 


Val Val Leu Asn Glu Leu Asn Asn Leu Lys Ile Asn Gln Glu Ile Ile 
545                 550                 555                 560 


Thr Pro Gly Gln Lys Gln Tyr Leu Tyr Glu His Val Met Lys Lys Asn 
                565                 570                 575     


Lys Arg Val Thr Leu Lys Lys Ile Ala Asp Ala Leu Val Ile Lys Gly 
            580                 585                 590         


Asp Tyr Pro Tyr Ala Pro Glu Val Lys Gly Thr Thr Asp Gln Lys Asn 
        595                 600                 605             


Leu Asn Asn Gly Leu Thr Thr Tyr Ile Asp Leu Ala Lys Ile Phe Gly 
    610                 615                 620                 


Asn Glu Leu Asp Asp Val Asp Arg Glu Ala Asp Phe Glu Lys Ile Ile 
625                 630                 635                 640 


Glu Trp Ser Thr Ile Phe Glu Asp Gln His Ile Phe Ala Leu Lys Leu 
                645                 650                 655     


Gln Glu Leu Lys Trp Leu Thr Glu Lys Gln Arg Asn Gln Val Val Lys 
            660                 665                 670         


Leu Arg Tyr Gln Gly Trp Gly Lys Leu Ser Lys Glu Leu Leu Ala Gly 
        675                 680                 685             


Leu Val Asp Asp Asn Gly Gln Arg Ile Ile Asp Leu Leu Trp Ser Asp 
    690                 695                 700                 


Asn Gln Asn Phe Met Gln Ile Val Asn Gln Lys Ser Phe Lys Glu Ser 
705                 710                 715                 720 


Ile Ala Asp His Asn Gly Ala His Leu Glu Glu Lys Asn Leu Lys Asp 
                725                 730                 735     


Val Ile Asn Asp Leu Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile Arg 
            740                 745                 750         


Gln Val Ile Leu Val Val Asp Asp Ile Ile Asn Ala Val Gly Tyr Glu 
        755                 760                 765             


Pro Ala Asn Ile Met Met Glu Phe Ala Arg Glu Asp Ser Asn Asp His 
    770                 775                 780                 


Arg Leu Thr Asn Ser Arg Ser Arg Gln Leu Glu Asn Val Tyr Lys Asp 
785                 790                 795                 800 


Ile Thr Asn Ser Trp Phe Asp Asn Asp Ser Val Lys Asp Glu Leu Glu 
                805                 810                 815     


Asp Lys Ile Lys Asn Lys Asp Lys Phe Thr Asp Arg Leu Tyr Leu Tyr 
            820                 825                 830         


Phe Thr Gln Gly Gly Lys Asp Leu Tyr Thr Gly Glu Pro Leu Asn Ile 
        835                 840                 845             


Asp Asp Leu Ser Ser Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Phe 
    850                 855                 860                 


Ile Leu Asp Asn Ser Leu Asp Asn Arg Val Leu Thr Ser Gln Arg Asn 
865                 870                 875                 880 


Asn Arg Val Ser Lys Glu Asp Gln Leu Pro Gly Glu Leu Phe Gly Thr 
                885                 890                 895     


Lys Met His Ala Phe Trp Lys Arg Leu Lys Ala Ala His Leu Ile Ser 
            900                 905                 910         


Asn Lys Lys Tyr Tyr Asn Leu Thr Leu Thr Pro Asn Ser Ile Ser Lys 
        915                 920                 925             


Phe Asn Asn Gln Gly Arg Phe Ile Asn Arg Gln Leu Val Glu Thr Arg 
    930                 935                 940                 


Gln Val Ile Lys Leu Ala Ala Glu Ile Leu His Asn Arg Tyr Ser Glu 
945                 950                 955                 960 


Glu Lys Gly Thr Asn Ile Val Thr Ile Lys Ala Asn Leu Thr His His 
                965                 970                 975     


Met Arg Glu Lys Phe Asn Phe Tyr Lys Asn Arg Asn Val Asn Asp Tyr 
            980                 985                 990         


His His Ala Phe Asp Ala Tyr Leu  Thr Ala Phe Val Gly  Asn Trp Leu 
        995                 1000                 1005             


Leu Gln  Gln Tyr Pro Lys Leu  Lys Pro Tyr Phe Val  Tyr Gly Asp 
    1010                 1015                 1020             


Phe Ala  Lys Thr Glu Ile Asn  Asn Leu Lys Ser Phe  Asn Met Leu 
    1025                 1030                 1035             


Tyr Lys  Phe Glu Gln Ala His  Gln Leu Asn Glu Lys  Asp Gly Lys 
    1040                 1045                 1050             


Ile Ala  Lys Asp Ala Asp Ala  Leu Leu Gly Tyr Met  Lys Asn Val 
    1055                 1060                 1065             


Tyr His  Phe Lys Lys Met Leu  Val Thr Lys Lys Leu  Glu Thr Asn 
    1070                 1075                 1080             


His Gly  Ala Leu Phe Lys Gln  Thr Leu Tyr Pro Ser  Pro Ala His 
    1085                 1090                 1095             


Asp Ile  Lys Lys Arg Gln Leu  Ile Lys Pro Lys Asp  Asn Arg Pro 
    1100                 1105                 1110             


Thr Asp  Ile Tyr Gly Gly Tyr  Thr His Glu Glu Arg  Lys Tyr Met 
    1115                 1120                 1125             


Ser Leu  Val Lys Val Ile Gly  Lys Lys Asp Asn Glu  Tyr Arg Met 
    1130                 1135                 1140             


Ala Asn  Val Pro Leu Leu Lys  Ile Asn Lys Asn Asn  Asp Ile Lys 
    1145                 1150                 1155             


Glu Ile  Leu Lys Ser Gln Phe  Ser Asn Lys Lys Phe  Glu Ile Val 
    1160                 1165                 1170             


Leu Pro  Lys Val Leu Lys Asn  Gln Leu Phe Ser Glu  Asn Gly Ala 
    1175                 1180                 1185             


Leu Phe  Val Ile Gly Ser Lys  Gly Tyr Lys Tyr Asn  Ala Asn Gln 
    1190                 1195                 1200             


Leu Val  Leu Ser Asp Leu Asp  Met Lys Leu Leu Asn  Asp Leu Ser 
    1205                 1210                 1215             


Asn Asn  Lys Ser Ile Asp Glu  Val Thr Ile Asn Gln  Leu Phe Lys 
    1220                 1225                 1230             


Asn Ile  Val Asp Ser Thr Asn  Lys Tyr Met Pro Leu  Tyr Glu Ile 
    1235                 1240                 1245             


Lys Asn  Leu Asn Glu Val Val  Glu Lys Phe Asn Asn  Leu Glu Phe 
    1250                 1255                 1260             


Asn Asp  Lys Lys Lys Thr Ile  Thr Asp Phe Leu Leu  Ala Thr His 
    1265                 1270                 1275             


Ala Asn  Pro Thr Met Ser Asn  Leu Lys Asn Ile Gly  Leu Pro Ser 
    1280                 1285                 1290             


Tyr Phe  Gly Arg Phe Thr Ser  Gly Asn Ala Gly Ile  Lys Leu Ser 
    1295                 1300                 1305             


Glu Asn  Ala Asn Val Ile Tyr  Gln Ser Pro Thr Gly  Leu Phe Ser 
    1310                 1315                 1320             


Arg Lys  Val Lys Ile Ser Asp  Phe 
    1325                 1330     


<210> 301
<211> 1419
<212> PRT
<213> Lactobacillus sp.


<220>
<223> Lactobacillus sp. 66c

<400> 301
Met Ala Lys Pro Gln Asn Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn 
1               5                   10                  15      


Ser Val Gly Trp Thr Val Thr Asp Asp Gln Asn Asn Ile Leu Arg Ile 
            20                  25                  30          


Lys Ser Lys Lys Ala Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys Val 
        35                  40                  45              


Ala Ala Glu Arg Arg Ser Phe Arg Thr Thr Arg Arg Arg Leu Ser Arg 
    50                  55                  60                  


Arg Lys Trp Arg Ile Lys Leu Leu Glu Glu Leu Phe Asp Glu Glu Ile 
65                  70                  75                  80  


Ser Lys Val Asp Pro Asn Phe Phe Ala Arg Ser His Glu Ser Trp Ile 
                85                  90                  95      


Ser Pro Lys Asp Lys Arg Glu Arg Tyr Ser Ala Ile Val Phe Pro Thr 
            100                 105                 110         


Pro Glu Glu Asp Lys Lys Phe His Asn Glu Tyr Pro Thr Ile Tyr His 
        115                 120                 125             


Leu Arg Asp Arg Leu Met Lys Asp Asp Gln Lys His Asp Ile Arg Glu 
    130                 135                 140                 


Ile Tyr Val Ala Ile His His Ile Met Lys Tyr Arg Gly Asn Phe Leu 
145                 150                 155                 160 


His Asp Glu Ser Ile Glu Thr Tyr Arg Ser Gly Met Ser Ser Leu Gly 
                165                 170                 175     


Gly Gly Asp Glu Arg Thr Ile Leu Asn Thr Lys Ile Leu Asp Asp Leu 
            180                 185                 190         


Asn Asp Ala Phe Ala Asp Asn Leu Ala Thr Gln Gly Ile Ser Val Asn 
        195                 200                 205             


Ser Ala Ser Ala Asp Gln Ile Asn Glu Ile Val Thr Ser Gly His Leu 
    210                 215                 220                 


Asn Val Asp Ser Gln Lys Ala Ile Ala Lys Leu Leu Leu Pro Thr Thr 
225                 230                 235                 240 


Leu Ser Ser Asp Asp Lys Lys Gln Asp Lys Lys Ile Lys Lys Leu Ala 
                245                 250                 255     


Thr Asp Ala Ala Lys Asn Val Ala Ser Ala Trp Leu Gly Tyr Lys Ala 
            260                 265                 270         


Asn Phe Ala Ala Ile Leu Asn Ile Gln Glu Val Asp Lys Asp Lys Lys 
        275                 280                 285             


Lys Ile Tyr Ser Phe Ala Leu Gln Gly Ala Asp Glu Glu Asp Lys Val 
    290                 295                 300                 


Glu Thr Leu Glu Ser Val Leu Ser Gln Asp Gln Ile Glu Ile Val Asp 
305                 310                 315                 320 


Arg Ile Ile Arg Ile Arg His Ala Ile Val Leu Gly Glu Ile Ile Pro 
                325                 330                 335     


Val Gly Met Thr Leu Ser Glu Ala Met Ile Glu Lys Tyr Asp Gln His 
            340                 345                 350         


Ala Lys Asp Leu Lys Asn Leu Lys Thr Val Ile Arg Asn Leu Lys Asp 
        355                 360                 365             


Arg Lys Asn Ala Val Lys Leu Gln Ala Ile Tyr Asp Leu Tyr Val Asn 
    370                 375                 380                 


Asn Arg His Ala Asp Thr Ala Lys Ala Met Lys Leu Ala Gly Val Lys 
385                 390                 395                 400 


Lys Arg Thr Glu Leu Leu Glu Pro Glu Glu Phe Asn Lys Ser Ile Glu 
                405                 410                 415     


Lys Leu Leu Asp Asp Ser Pro Val Ser Ala Glu Ile Lys Lys Arg Ile 
            420                 425                 430         


Ala Glu Lys Asp Phe Leu Pro Leu Gln Arg Ser Asn Ser Asn Gly Val 
        435                 440                 445             


Ile Pro Asn Gln Leu His Gln Ile Glu Leu Asp Glu Ile Ile Lys Lys 
    450                 455                 460                 


Gln Ser Lys Tyr Tyr Pro Phe Leu Gly Glu Thr Asn Glu His Ala Ser 
465                 470                 475                 480 


Ala Asp Val Ala Arg Lys Ala Pro Thr Lys Leu Asp Gln Leu Leu Thr 
                485                 490                 495     


Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Ile Thr Lys Glu Glu Gln 
            500                 505                 510         


Glu Glu Gln Asp Gly His Ser Phe Ala Trp Met Ile Arg Lys Asn Pro 
        515                 520                 525             


Lys Asp His Glu Lys Ile Thr Pro Trp Asn Phe Asp Glu Lys Val Asp 
    530                 535                 540                 


Arg Met Ala Ser Ala Thr Gln Phe Ile Lys Arg Met Thr Thr Lys Asp 
545                 550                 555                 560 


Thr Tyr Leu Leu Gly Glu Asp Val Leu Pro Ser Ser Ser Leu Lys Tyr 
                565                 570                 575     


Gln Leu Phe Thr Val Leu Asn Glu Leu Asn Asn Leu Arg Ile Asn His 
            580                 585                 590         


Lys Lys Leu Thr Arg Glu Glu Lys Glu Gln Val Ile Glu Asp Leu Phe 
        595                 600                 605             


Lys Lys Tyr Lys Thr Val Lys Ala Asp Lys Phe Lys Asn Tyr Trp Gln 
    610                 615                 620                 


Lys Gly His Ala Gly Leu Asp Val Lys Ile Gln Gly Met Ala Asp Pro 
625                 630                 635                 640 


Glu Lys Phe Asn Ser Thr Met Ser Thr Tyr Ile Asp Leu Gln Lys Ile 
                645                 650                 655     


Phe Gly Asp Gln Leu Asp Asp Ala Gln Arg Gln Asn Asp Phe Glu Lys 
            660                 665                 670         


Ile Ile Glu Tyr Ser Thr Ile Phe Glu Asp Arg Lys Ile Leu Gly Glu 
        675                 680                 685             


Lys Leu Arg Ala Asp Phe Val Trp Leu Ser Glu Asp Gln Ile Lys Arg 
    690                 695                 700                 


Leu Cys Arg Leu Arg Leu Gln Gly Trp Gly Arg Leu Ser Leu Lys Leu 
705                 710                 715                 720 


Leu Thr Arg Leu Thr Asp Ala Asp Gly Gln Asn Val Leu Glu Arg Leu 
                725                 730                 735     


Leu Asn Ser Asn Asp Asn Phe Met Gln Ile Val Lys Asp Pro Val Ile 
            740                 745                 750         


Lys Ala Lys Ile Glu Gln Lys Asn Gln Lys Leu Leu Arg Ala Asp Trp 
        755                 760                 765             


Ser Glu Asn Ala Thr Glu Ser Ile Leu Asp Glu Ala Tyr Thr Ser Pro 
    770                 775                 780                 


Gln Asn Lys Lys Ala Ile Arg Gln Val Met Arg Val Val His Asp Ile 
785                 790                 795                 800 


Val Lys Ala Cys Asp Gly Asn Leu Pro Ala Lys Phe Ala Ile Glu Phe 
                805                 810                 815     


Ala Arg Ser Gln Asp Asp Asp Pro Lys Arg Thr Val Ala Arg Ala Asp 
            820                 825                 830         


Arg Leu Gln Lys Ile Tyr Ala Gln Ile Ser Asp Glu Val Val Ser Gln 
        835                 840                 845             


Gly Val Lys Asp Gln Leu Ser Gly Met Lys Ser Leu Lys Asp Arg Tyr 
    850                 855                 860                 


Tyr Leu Tyr Phe Met Gln Gly Gly Arg Asp Ala Tyr Thr Gly Lys Pro 
865                 870                 875                 880 


Leu Asn Ile Asp Arg Leu Ser Asp Tyr Asp Ile Asp His Ile Met Pro 
                885                 890                 895     


Gln Ser Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Val Thr 
            900                 905                 910         


Arg Ala Val Asn Asn Gln Lys Ser Asp Asn Val Pro Val Leu Leu Tyr 
        915                 920                 925             


Gly Asn His Leu Val Ala Asp Leu Gly Ile Thr Ile Arg Glu Met Trp 
    930                 935                 940                 


Asp Arg Trp Gln Lys Ser Gly Met Ile Ser Lys Arg Lys Leu Ala Asn 
945                 950                 955                 960 


Leu Leu Thr Asp Pro Ala Thr Leu Ser Glu Tyr Arg Ala Glu Gly Phe 
                965                 970                 975     


Ile Asn Arg Gln Leu Val Glu Thr Ser Gln Val Ile Lys Leu Thr Ala 
            980                 985                 990         


Thr Ile Leu Gln Ser Glu Phe Pro  Asp Ser Lys Ile Ile  Glu Val Pro 
        995                 1000                 1005             


Ala Lys  Tyr Asn Ser Ile Leu  Arg Lys Gln Phe Asp  Leu Tyr Lys 
    1010                 1015                 1020             


Ser Arg  Glu Val Asn Asp Tyr  His His Ala Ile Asp  Ala Tyr Leu 
    1025                 1030                 1035             


Ser Thr  Ile Val Gly Asn Tyr  Leu Tyr Gln Val Tyr  Pro Asn Leu 
    1040                 1045                 1050             


Arg Arg  Leu Phe Val Tyr Gly  Glu Phe Lys Lys Phe  Ser His Gly 
    1055                 1060                 1065             


Glu Glu  Glu Ser Ser His Gln  Ala Val Arg Arg Val  Lys Ser Met 
    1070                 1075                 1080             


Asn Phe  Leu Asp Asp Leu Leu  Arg Gly Lys His Gly  Asp Asp Ile 
    1085                 1090                 1095             


Tyr Cys  Arg Val Thr Gly Glu  Val Ile Phe Ser Arg  Lys Asp Ile 
    1100                 1105                 1110             


Ile Ser  Lys Leu Lys Gln Ala  Tyr Ser Phe Lys Gln  Met Leu Val 
    1115                 1120                 1125             


Thr Gln  Glu Val Phe Thr Lys  Lys Ser Ala Leu Phe  Asp Gln Thr 
    1130                 1135                 1140             


Val Tyr  Pro Ser Pro Ala Arg  Asp Ser Lys Thr Arg  Ser Gly Leu 
    1145                 1150                 1155             


Ile Pro  Arg Lys Gln Gly Met  Asp Thr Glu Ile Tyr  Gly Gly Tyr 
    1160                 1165                 1170             


Ser Gly  Asn Lys Asp Ala Tyr  Phe Val Leu Ala Gln  Val Val Lys 
    1175                 1180                 1185             


Ser Lys  Gly His Thr Leu Gln  Val Val Gly Val Pro  Ile Arg Ala 
    1190                 1195                 1200             


Leu Arg  Ala Leu Ala Asn Cys  Ser Asn Tyr Ser Glu  Gln Leu Leu 
    1205                 1210                 1215             


Lys Ile  Val Lys Ala Gln Val  Leu Phe Asn Lys Lys  Thr Gly Lys 
    1220                 1225                 1230             


Ala Lys  Lys Gly Ile Ser Asp  Val Arg Ile Leu Leu  Asp Lys Ile 
    1235                 1240                 1245             


Pro Tyr  Arg Gln Pro Val Leu  Asp Gly Ser Ala Phe  Tyr Met Leu 
    1250                 1255                 1260             


Gly Ser  Ser Thr Tyr Lys Tyr  Asn Leu Lys Gln Ile  Ser Leu Ser 
    1265                 1270                 1275             


Gln Gln  Ser Met Lys Tyr Ile  Leu Asp Tyr Ile Asp  Asp Pro Asn 
    1280                 1285                 1290             


Phe Asn  Lys His Glu Met Thr  Lys Ile Asp Gln Gln  Asn Glu Lys 
    1295                 1300                 1305             


Glu Cys  Leu Leu Ser Val Tyr  Asp Glu Ile Leu Asp  Lys Met Asp 
    1310                 1315                 1320             


Lys Tyr  Leu Ser Leu Tyr Asp  Ile Asn Gly Phe Arg  Lys Lys Leu 
    1325                 1330                 1335             


His Val  Gly Arg Asp Lys Phe  Ile Lys Leu Glu Val  Glu Lys Gln 
    1340                 1345                 1350             


Ala Glu  Ala Ile Lys Asn Val  Leu Arg Gly Phe His  Ala Asn Ser 
    1355                 1360                 1365             


Asp Met  Thr Lys Leu Ser Asp  Leu Gly Leu Ser Thr  Ser Leu Gly 
    1370                 1375                 1380             


Phe Met  Gln Ala Ser Asp Gly  Ile Lys Leu Ser Asp  Asn Ala Val 
    1385                 1390                 1395             


Phe Ile  Tyr Gln Ser Pro Thr  Gly Leu Phe Glu Arg  Arg Val Lys 
    1400                 1405                 1410             


Val Ser  Asp Leu Leu Lys 
    1415                 


<210> 302
<211> 1289
<212> PRT
<213> Lactobacillus versmoldensis


<220>
<223> Lactobacillus versmoldensis KCTC 3814

<400> 302
Met Arg Arg Arg Tyr Arg Arg Arg Arg Asn Arg Leu Asn Trp Leu Asp 
1               5                   10                  15      


Glu Leu Phe Ala Asp Glu Leu Ala Lys Ile Asp Pro Ser Phe Leu Leu 
            20                  25                  30          


Arg Met Lys Asn Ser Trp Val Ser Lys Lys Glu Ser Thr Arg Lys Arg 
        35                  40                  45              


Asp Pro Tyr Asn Leu Phe Ile Asp Glu Lys Tyr Asn Asp Val Asp Tyr 
    50                  55                  60                  


Phe Asn Gln Tyr Pro Thr Ile Phe His Leu Arg Lys Glu Leu Ile Thr 
65                  70                  75                  80  


Glu Asp Lys Lys Val Asp Ile Arg Leu Ile Tyr Leu Ala Ile His Asn 
                85                  90                  95      


Ile Ile Lys Tyr Arg Gly Asn Phe Thr Leu Glu Asn Gln Asn Phe Asp 
            100                 105                 110         


Ile Ser Gln Leu Ser Ser Asn Phe Ser Gln Gln Ile Ser Asp Phe Phe 
        115                 120                 125             


Ala Leu Phe Ser Asp Phe Gly Val Ile Met Pro Glu Asp Phe Asp Pro 
    130                 135                 140                 


Asp Lys Ile Ser Asp Ile Leu Leu Asn Pro Asn Leu Ser Pro Ser Gly 
145                 150                 155                 160 


Lys Val Ser Glu Ala Ile Ala Thr Ile Ser Pro Lys Thr Asn Val Lys 
                165                 170                 175     


Ala Lys Ile Lys Ile Ile Leu Leu Leu Leu Val Gly Asn Asn Gly Asp 
            180                 185                 190         


Leu Lys Lys Leu Phe Asp Leu Glu Thr Thr Glu Lys Ile Ala Val Lys 
        195                 200                 205             


Leu Ser Ser Arg His Ile Asp Ser Glu Leu Pro Ile Ile Leu Ser Glu 
    210                 215                 220                 


Leu Asn Glu Gln Gln Glu Asn Ile Ile Thr Ile Ala Asn Ser Ile Phe 
225                 230                 235                 240 


Gly Ser Ile Ile Leu Lys Asp Phe Leu Gly Asp Glu Thr Ser Ile Ser 
                245                 250                 255     


Ala Ala Lys Val Ile Ser Phe Glu Asp His Lys Gln Asp Leu Gln Lys 
            260                 265                 270         


Leu Lys Thr Met Trp Arg Glu Thr Ser Asn Lys Glu Ala Val Lys Ala 
        275                 280                 285             


Gly Lys Lys Ala Tyr Glu Asp Tyr Ile Gly His Glu Asp Ser Glu Thr 
    290                 295                 300                 


Phe Tyr Lys Lys Ile Lys Lys Phe Leu Glu Lys Ala Gln Pro Val Asp 
305                 310                 315                 320 


Leu Ala Asn Lys Ala Leu Ala Glu Ile Glu Leu Glu Asn Tyr Leu Pro 
                325                 330                 335     


Lys Gln Arg Asn Arg Asn Asn Thr Val Ile Pro Tyr Gln Leu Asn Glu 
            340                 345                 350         


Asn Glu Leu Ile Ala Ile Leu Asp His Gln Glu Lys Tyr Tyr Pro Phe 
        355                 360                 365             


Leu Lys Glu Asn Arg Asp Lys Ile Leu Ser Leu Leu Thr Phe Arg Ile 
    370                 375                 380                 


Pro Tyr Tyr Val Gly Pro Leu Gln Asp Ser Asn Asn Asn Arg Phe Ser 
385                 390                 395                 400 


Trp Met Thr Arg Lys Ala Ser Gly Ala Ile Arg Pro Trp Asn Phe Ser 
                405                 410                 415     


Glu Lys Val Asn Val Glu Gln Ser Ser Asn Asp Phe Ile Lys Arg Met 
            420                 425                 430         


Arg Ser Thr Asp Thr Tyr Leu Ile Gly Glu Pro Val Leu Pro Lys Lys 
        435                 440                 445             


Ser Leu Ile Tyr Gln Cys Tyr Glu Val Leu Ser Glu Leu Asn Asn Thr 
    450                 455                 460                 


Arg Val Lys Asp Gly Ser Ser Asn Pro Lys Arg Leu Asp Val Thr Ile 
465                 470                 475                 480 


Lys Gln Arg Ile Tyr Asn Glu Ile Phe Lys Asn Gln Lys Ser Val Ser 
                485                 490                 495     


Val Lys Val Leu Gln Asn Trp Leu Ile Lys Glu Ser Tyr Phe Lys Ser 
            500                 505                 510         


Pro Glu Ile Ser Gly Leu Ala Asp Lys Lys Lys Tyr Leu Ser Ser Leu 
        515                 520                 525             


Ser Thr Tyr Ile Asp Phe Lys Lys Ile Phe Gly Gln Arg Phe Val Asp 
    530                 535                 540                 


Asp Pro Val Asn Ser Pro Gln Leu Glu Glu Leu Ala Glu Trp Leu Thr 
545                 550                 555                 560 


Leu Phe Glu Asp Lys Lys Ile Leu Leu Ile Lys Leu Gln Asn Ser Lys 
                565                 570                 575     


Tyr Ser Tyr Asp Gln Ala Thr Ile Asn Lys Leu Ser Thr Met Arg Tyr 
            580                 585                 590         


Gln Gly Thr Gly Lys Leu Ser Lys Lys Leu Leu Val Asp Leu Lys Thr 
        595                 600                 605             


Thr Lys Lys Ser Ile Gly Lys Ser Gly Ala Glu Ser Leu Ser Ile Leu 
    610                 615                 620                 


Asp Leu Met Trp Ser Thr Lys Asp Asn Phe Met Gln Ile Ile His Asp 
625                 630                 635                 640 


Ala Asp Tyr Thr Phe Glu Gln Gln Ile Lys Glu Phe Asn Tyr Asp Thr 
                645                 650                 655     


Glu Asp Glu Leu Thr Pro Leu Glu Lys Val Ala Asn Leu His Gly Ser 
            660                 665                 670         


Pro Ala Leu Lys Arg Gly Leu Asn Gln Ser Ile Lys Val Val Ala Asp 
        675                 680                 685             


Ile Val Lys Phe Met Gly His Asp Pro Glu Lys Ile Phe Ile Glu Phe 
    690                 695                 700                 


Thr Arg Ser Asp Asp Phe Ser Lys Leu Thr Ile Ser Arg Tyr Arg Arg 
705                 710                 715                 720 


Ile Lys Lys Gln Tyr Leu Glu Ile Ala Lys Ala Ile Lys Lys Ile Pro 
                725                 730                 735     


Ala Glu Phe Lys Asp Ile Lys Glu Tyr Gln Thr Gln Leu Glu Glu Asn 
            740                 745                 750         


Lys Gly Lys Leu Ala Ser Glu Arg Leu Met Leu Tyr Phe Leu Gln Cys 
        755                 760                 765             


Gly His Ser Leu Tyr Ser Asn Lys Pro Ile Asp Leu Asn Met Ile Asn 
    770                 775                 780                 


Ser Ser Lys Tyr His Val Asp His Ile Leu Pro Gln Ser Tyr Ile Lys 
785                 790                 795                 800 


Asp Asp Ser Leu Glu Asn Lys Ala Leu Val Leu Ala Ser Glu Asn Glu 
                805                 810                 815     


Asn Lys Ile Asp Asn Met Leu Ile Ser His Asp Ile Ile Ala Thr Asn 
            820                 825                 830         


Leu Pro Arg Trp Gln Ala Leu Lys Asp Gln Asn Leu Met Gly Ser Lys 
        835                 840                 845             


Lys Phe Ala Asp Leu Thr Arg Thr Thr Val Thr Glu Asn Gln Lys Lys 
    850                 855                 860                 


Gly Phe Ile Gln Arg Gln Leu Val Gln Thr Ser Gln Ile Val Lys Asn 
865                 870                 875                 880 


Ile Thr Leu Ile Leu Asn Asp Leu Tyr Lys Asn Thr Ser Cys Ile Glu 
                885                 890                 895     


Thr Arg Ala Thr Leu Ser Ser Glu Phe Arg Lys Ala Phe Ser Asn Phe 
            900                 905                 910         


Asp Glu Thr Thr Tyr His Tyr Gln Phe Pro Glu Phe Val Lys Asn Arg 
        915                 920                 925             


Asp Val Asn Asp Phe His His Ala Gln Asp Ala Phe Leu Ala Cys Val 
    930                 935                 940                 


Ile Gly Glu Tyr Gln Leu Lys Lys Tyr Pro Lys Asp Asn Leu Arg Leu 
945                 950                 955                 960 


Val Tyr Asp Gln Tyr Ser Lys Phe Leu Asp Ser Leu Lys Lys Asp Thr 
                965                 970                 975     


Arg Lys Lys Asn Gly Arg Met Pro Arg Tyr Thr Gln Asn Gly Phe Ile 
            980                 985                 990         


Ile Gly Ser Met Phe Asn Gly Lys  Thr Tyr Val Asp Asp  Asn Gly Glu 
        995                 1000                 1005             


Ile Ile  Trp Asp Gln Lys Ile  Lys Glu Ser Ile Arg  Lys Thr Phe 
    1010                 1015                 1020             


Asn Tyr  His Gln Phe Asn Val  Val Arg Gln Thr Ile  Glu Gln His 
    1025                 1030                 1035             


Gly Lys  Leu Phe Asn Asp Thr  Ile Gln Pro His Ser  Asp Arg Tyr 
    1040                 1045                 1050             


Lys Leu  Ile Pro Leu Lys Thr  Asn Arg Asp Pro Ala  Ile Tyr Gly 
    1055                 1060                 1065             


Gly Tyr  Asn Asn Asp Asn Asn  Ala Tyr Ser Val Val  Leu Asp Val 
    1070                 1075                 1080             


Asp Gly  Lys Lys Lys Ile Asn  Gly Ile Pro Ile Arg  Ile Ala Asn 
    1085                 1090                 1095             


Gln Leu  Lys Ser Asp Glu Leu  Asp Leu Ser Ser Trp  Leu Glu Asn 
    1100                 1105                 1110             


Asn Ile  Lys His Lys Lys Pro  Met Thr Ile Leu Ile  Asp Lys Val 
    1115                 1120                 1125             


Pro Lys  Tyr Gln Arg Ile Ile  Asn Glu Glu Thr Gly  Asp Leu Leu 
    1130                 1135                 1140             


Ile Thr  Ser Ala Asn Glu Val  Ile Asn Asn Val Gln  Leu Phe Leu 
    1145                 1150                 1155             


Pro Ser  Met Tyr Thr Ala Leu  Ile Ser Leu Leu Asp  Ser Thr Lys 
    1160                 1165                 1170             


Thr Glu  Met Tyr Ser Lys Leu  Leu Ser Asn Tyr Glu  Ala Asn Ile 
    1175                 1180                 1185             


Leu Ile  Asp Ile Tyr Asp Tyr  Leu Leu Thr Lys Leu  Lys Asn Asn 
    1190                 1195                 1200             


Tyr Pro  Leu Tyr Arg Lys Glu  Trp Ala Lys Leu Ala  Glu His Arg 
    1205                 1210                 1215             


Asp Asp  Phe Ile Glu Ser Asp  Leu Val Thr Gln Ala  Ser Thr Leu 
    1220                 1225                 1230             


Gln Gln  Leu Ile Lys Phe Met  His Ala Asp Pro Ser  Asn Val Asn 
    1235                 1240                 1245             


Leu Lys  Phe Gly Asn Phe Lys  Gly Asn Arg Phe Gly  Arg Lys Asn 
    1250                 1255                 1260             


Gly Asn  Ile Lys Leu Ser Lys  Thr Asp Phe Ile Tyr  Glu Ser Pro 
    1265                 1270                 1275             


Thr Gly  Leu Phe Lys Ser Ile  Lys His Ile Asp 
    1280                 1285                 


<210> 303
<211> 1372
<212> PRT
<213> Legionella pneumophila


<220>
<223> Legionella pneumophila 130b

<400> 303
Met Glu Ser Ser Gln Ile Leu Ser Pro Ile Gly Ile Asp Leu Gly Gly 
1               5                   10                  15      


Lys Phe Thr Gly Val Cys Leu Ser His Leu Glu Ala Phe Ala Glu Leu 
            20                  25                  30          


Pro Asn His Ala Asn Thr Lys Tyr Ser Val Ile Leu Ile Asp His Asn 
        35                  40                  45              


Asn Phe Gln Leu Ser Gln Ala Gln Arg Arg Ala Thr Arg His Arg Val 
    50                  55                  60                  


Arg Asn Lys Lys Arg Asn Gln Phe Val Lys Arg Val Ala Leu Gln Leu 
65                  70                  75                  80  


Phe Gln His Ile Leu Ser Arg Asp Leu Asn Ala Lys Glu Glu Thr Ala 
                85                  90                  95      


Leu Cys His Tyr Leu Asn Asn Arg Gly Tyr Thr Tyr Val Asp Thr Asp 
            100                 105                 110         


Leu Asp Glu Tyr Ile Lys Asp Glu Thr Thr Ile Asn Leu Leu Lys Glu 
        115                 120                 125             


Leu Leu Pro Ser Glu Ser Glu His Asn Phe Ile Asp Trp Phe Leu Gln 
    130                 135                 140                 


Lys Met Gln Ser Ser Glu Phe Arg Lys Ile Leu Val Ser Lys Val Glu 
145                 150                 155                 160 


Glu Lys Lys Asp Asp Lys Glu Leu Lys Asn Ala Val Lys Asn Ile Lys 
                165                 170                 175     


Asn Phe Ile Thr Gly Phe Glu Lys Asn Ser Val Glu Gly His Arg His 
            180                 185                 190         


Arg Lys Val Tyr Phe Glu Asn Ile Lys Ser Asp Ile Thr Lys Asp Asn 
        195                 200                 205             


Gln Leu Asp Ser Ile Lys Lys Lys Ile Pro Ser Val Cys Leu Ser Asn 
    210                 215                 220                 


Leu Leu Gly His Leu Ser Asn Leu Gln Trp Lys Asn Leu His Arg Tyr 
225                 230                 235                 240 


Leu Ala Lys Asn Pro Lys Gln Phe Asp Glu Gln Thr Phe Gly Asn Glu 
                245                 250                 255     


Phe Leu Arg Met Leu Lys Asn Phe Arg His Leu Lys Gly Ser Gln Glu 
            260                 265                 270         


Ser Leu Ala Val Arg Asn Leu Ile Gln Gln Leu Glu Gln Ser Gln Asp 
        275                 280                 285             


Tyr Ile Ser Ile Leu Glu Lys Thr Pro Pro Glu Ile Thr Ile Pro Pro 
    290                 295                 300                 


Tyr Glu Ala Arg Thr Asn Thr Gly Met Glu Lys Asp Gln Ser Leu Leu 
305                 310                 315                 320 


Leu Asn Pro Glu Lys Leu Asn Asn Leu Tyr Pro Asn Trp Arg Asn Leu 
                325                 330                 335     


Ile Pro Gly Ile Ile Asp Ala His Pro Phe Leu Glu Lys Asp Leu Glu 
            340                 345                 350         


His Thr Lys Leu Arg Asp Arg Lys Arg Ile Ile Ser Pro Ser Lys Gln 
        355                 360                 365             


Asp Glu Lys Arg Asp Ser Tyr Ile Leu Gln Arg Tyr Leu Asp Leu Asn 
    370                 375                 380                 


Lys Lys Ile Asp Lys Phe Lys Ile Lys Lys Gln Leu Ser Phe Leu Gly 
385                 390                 395                 400 


Gln Gly Lys Gln Leu Pro Ala Asn Leu Ile Glu Thr Gln Lys Glu Met 
                405                 410                 415     


Glu Thr His Phe Asn Ser Ser Leu Val Ser Val Leu Ile Gln Ile Ala 
            420                 425                 430         


Ser Ala Tyr Asn Lys Glu Arg Glu Asp Ala Ala Gln Gly Ile Trp Phe 
        435                 440                 445             


Asp Asn Ala Phe Ser Leu Cys Glu Leu Ser Asn Ile Asn Pro Pro Arg 
    450                 455                 460                 


Lys Gln Lys Ile Leu Pro Leu Leu Val Gly Ala Ile Leu Ser Glu Asp 
465                 470                 475                 480 


Phe Ile Asn Asn Lys Asp Lys Trp Ala Lys Phe Lys Asn Phe Trp Asn 
                485                 490                 495     


Thr His Lys Ile Gly Arg Thr Ser Leu Lys Ser Lys Cys Lys Glu Ile 
            500                 505                 510         


Glu Glu Ala Arg Lys Asn Ser Gly Asn Ala Phe Lys Ile Asp Tyr Glu 
        515                 520                 525             


Glu Ala Leu Asn His Pro Glu His Ser Asn Asn Lys Ala Leu Ile Lys 
    530                 535                 540                 


Ile Ile Gln Thr Ile Pro Asp Ile Ile Gln Ala Ile Gln Ser His Leu 
545                 550                 555                 560 


Gly His Asn Asp Ser Gln Ala Leu Ile Tyr His Asn Pro Phe Ser Leu 
                565                 570                 575     


Ser Gln Leu Tyr Thr Ile Leu Glu Thr Lys Arg Asp Gly Phe His Lys 
            580                 585                 590         


Asn Cys Val Ala Val Thr Cys Glu Asn Tyr Trp Arg Ser Gln Lys Thr 
        595                 600                 605             


Glu Ile Asp Pro Glu Ile Ser Tyr Ala Ser Arg Leu Pro Ala Asp Ser 
    610                 615                 620                 


Val Arg Pro Phe Asp Gly Val Leu Ala Arg Met Met Gln Arg Leu Ala 
625                 630                 635                 640 


Tyr Glu Ile Ala Met Ala Lys Trp Glu Gln Ile Lys His Ile Pro Asp 
                645                 650                 655     


Asn Ser Ser Leu Leu Ile Pro Ile Tyr Leu Glu Gln Asn Arg Phe Glu 
            660                 665                 670         


Phe Glu Glu Ser Phe Lys Lys Ile Lys Gly Gly Ser Ser Asp Lys Thr 
        675                 680                 685             


Leu Glu Gln Ala Ile Glu Lys Gln Asn Ile Gln Trp Glu Glu Lys Phe 
    690                 695                 700                 


Gln Arg Ile Ile Asn Ala Ser Met Asn Ile Cys Pro Tyr Lys Gly Ala 
705                 710                 715                 720 


Ser Ile Gly Gly Gln Gly Glu Ile Asp His Ile Tyr Pro Arg Ser Leu 
                725                 730                 735     


Ser Lys Lys His Phe Gly Val Ile Phe Asn Ser Glu Ala Asn Leu Ile 
            740                 745                 750         


Tyr Cys Ser Ser Gln Gly Asn Arg Glu Lys Lys Glu Glu His Tyr Leu 
        755                 760                 765             


Leu Glu His Leu Ser Pro Leu Tyr Leu Lys His Gln Phe Gly Thr Asp 
    770                 775                 780                 


Asn Val Ser Asp Ile Lys Asn Phe Ile Ser Gln Asn Val Ala Asn Ile 
785                 790                 795                 800 


Lys Lys Tyr Ile Ser Phe His Leu Leu Thr Pro Glu Gln Gln Lys Ala 
                805                 810                 815     


Ala Arg His Ala Leu Phe Leu Asp Tyr Asp Asp Glu Ala Phe Lys Thr 
            820                 825                 830         


Ile Thr Lys Phe Leu Met Ser Gln Gln Lys Ala Arg Val Asn Gly Thr 
        835                 840                 845             


Gln Lys Phe Leu Gly Lys Gln Ile Met Glu Phe Leu Ser Thr Leu Ala 
    850                 855                 860                 


Asp Ser Lys Gln Leu Gln Leu Glu Phe Ser Ile Lys Gln Ile Thr Ala 
865                 870                 875                 880 


Glu Glu Val His Asp His Arg Glu Leu Leu Ser Lys Gln Glu Pro Lys 
                885                 890                 895     


Leu Val Lys Ser Arg Gln Gln Ser Phe Pro Ser His Ala Ile Asp Ala 
            900                 905                 910         


Thr Leu Thr Met Ser Ile Gly Leu Lys Glu Phe Pro Gln Phe Ser Gln 
        915                 920                 925             


Glu Leu Asp Asn Ser Trp Phe Ile Asn His Leu Met Pro Asp Glu Val 
    930                 935                 940                 


His Leu Asn Pro Val Arg Ser Lys Glu Lys Tyr Asn Lys Pro Asn Ile 
945                 950                 955                 960 


Ser Ser Thr Pro Leu Phe Lys Asp Ser Leu Tyr Ala Glu Arg Phe Ile 
                965                 970                 975     


Pro Val Trp Val Lys Gly Glu Thr Phe Ala Ile Gly Phe Ser Glu Lys 
            980                 985                 990         


Asp Leu Phe Glu Ile Lys Pro Ser  Asn Lys Glu Lys Leu  Phe Thr Leu 
        995                 1000                 1005             


Leu Lys  Thr Tyr Ser Thr Lys  Asn Pro Gly Glu Ser  Leu Gln Glu 
    1010                 1015                 1020             


Leu Gln  Ala Lys Ser Lys Ala  Lys Trp Leu Tyr Phe  Pro Ile Asn 
    1025                 1030                 1035             


Lys Thr  Leu Ala Leu Glu Phe  Leu His His Tyr Phe  His Lys Glu 
    1040                 1045                 1050             


Ile Val  Thr Pro Asp Asp Thr  Thr Val Cys His Phe  Ile Asn Ser 
    1055                 1060                 1065             


Leu Arg  Tyr Tyr Thr Lys Lys  Glu Ser Ile Thr Val  Lys Ile Leu 
    1070                 1075                 1080             


Lys Glu  Pro Met Pro Val Leu  Ser Val Lys Phe Glu  Ser Ser Lys 
    1085                 1090                 1095             


Lys Asn  Val Leu Gly Ser Phe  Lys His Thr Ile Ala  Leu Pro Ala 
    1100                 1105                 1110             


Thr Lys  Asp Trp Glu Arg Leu  Phe Asn His Pro Asn  Phe Leu Ala 
    1115                 1120                 1125             


Leu Lys  Ala Asn Pro Ala Pro  Asn Pro Lys Glu Phe  Asn Glu Phe 
    1130                 1135                 1140             


Ile Arg  Lys Tyr Phe Leu Ser  Asp Asn Asn Pro Asn  Ser Asp Ile 
    1145                 1150                 1155             


Pro Asn  Asn Gly His Asn Ile  Lys Pro Gln Lys His  Lys Ala Val 
    1160                 1165                 1170             


Arg Lys  Val Phe Ser Leu Pro  Val Ile Pro Gly Asn  Ala Gly Thr 
    1175                 1180                 1185             


Met Met  Arg Ile Arg Arg Lys  Asp Asn Lys Gly Gln  Pro Leu Tyr 
    1190                 1195                 1200             


Gln Leu  Gln Thr Ile Asp Asp  Thr Pro Ser Met Gly  Ile Gln Ile 
    1205                 1210                 1215             


Asn Glu  Asp Arg Leu Val Lys  Gln Glu Val Leu Met  Asp Ala Tyr 
    1220                 1225                 1230             


Lys Thr  Arg Asn Leu Ser Thr  Ile Asp Gly Ile Asn  Asn Ser Glu 
    1235                 1240                 1245             


Gly Gln  Ala Tyr Ala Thr Phe  Asp Asn Trp Leu Thr  Leu Pro Val 
    1250                 1255                 1260             


Ser Thr  Phe Lys Pro Glu Ile  Ile Lys Leu Glu Met  Lys Pro His 
    1265                 1270                 1275             


Ser Lys  Thr Arg Arg Tyr Ile  Arg Ile Thr Gln Ser  Leu Ala Asp 
    1280                 1285                 1290             


Phe Ile  Lys Thr Ile Asp Glu  Ala Leu Met Ile Lys  Pro Ser Asp 
    1295                 1300                 1305             


Ser Ile  Asp Asp Pro Leu Asn  Met Pro Asn Glu Ile  Val Cys Lys 
    1310                 1315                 1320             


Asn Lys  Leu Phe Gly Asn Glu  Leu Lys Pro Arg Asp  Gly Lys Met 
    1325                 1330                 1335             


Lys Ile  Val Ser Thr Gly Lys  Ile Val Thr Tyr Glu  Phe Glu Ser 
    1340                 1345                 1350             


Asp Ser  Thr Pro Gln Trp Ile  Gln Thr Leu Tyr Val  Thr Gln Leu 
    1355                 1360                 1365             


Lys Lys  Gln Pro 
    1370         


<210> 304
<211> 1372
<212> PRT
<213> Legionella pneumophila

<400> 304
Met Glu Ser Ser Gln Ile Leu Ser Pro Ile Gly Ile Asp Leu Gly Gly 
1               5                   10                  15      


Lys Phe Thr Gly Val Cys Leu Ser His Leu Glu Ala Phe Ala Glu Leu 
            20                  25                  30          


Pro Asn His Ala Asn Thr Lys Tyr Ser Val Ile Leu Ile Asp His Asn 
        35                  40                  45              


Asn Phe Gln Leu Ser Gln Ala Gln Arg Arg Ala Thr Arg His Arg Val 
    50                  55                  60                  


Arg Asn Lys Lys Arg Asn Gln Phe Val Lys Arg Val Ala Leu Gln Leu 
65                  70                  75                  80  


Phe Gln His Ile Leu Ser Arg Asp Leu Asn Ala Lys Glu Glu Thr Ala 
                85                  90                  95      


Leu Cys His Tyr Leu Asn Asn Arg Gly Tyr Thr Tyr Val Asp Thr Asp 
            100                 105                 110         


Leu Asp Glu Tyr Ile Lys Asp Glu Thr Thr Ile Asn Leu Leu Lys Glu 
        115                 120                 125             


Leu Leu Pro Ser Glu Ser Glu His Asn Phe Ile Asp Trp Phe Leu Gln 
    130                 135                 140                 


Lys Met Gln Ser Ser Glu Phe Arg Lys Ile Leu Val Ser Lys Val Glu 
145                 150                 155                 160 


Glu Lys Lys Asp Asp Lys Glu Leu Lys Asn Ala Val Lys Asn Ile Lys 
                165                 170                 175     


Asn Phe Ile Thr Gly Phe Glu Lys Asn Ser Val Glu Gly His Arg His 
            180                 185                 190         


Arg Lys Val Tyr Phe Glu Asn Ile Lys Ser Asp Ile Thr Lys Asp Asn 
        195                 200                 205             


Gln Leu Asp Ser Ile Lys Lys Lys Ile Pro Ser Val Cys Leu Ser Asn 
    210                 215                 220                 


Leu Leu Gly His Leu Ser Asn Leu Gln Trp Lys Asn Leu His Arg Tyr 
225                 230                 235                 240 


Leu Ala Lys Asn Pro Lys Gln Phe Asp Glu Gln Thr Phe Gly Asn Glu 
                245                 250                 255     


Phe Leu Arg Met Leu Lys Asn Phe Arg His Leu Lys Gly Ser Gln Glu 
            260                 265                 270         


Ser Leu Ala Val Arg Asn Leu Ile Gln Gln Leu Glu Gln Ser Gln Asp 
        275                 280                 285             


Tyr Ile Ser Ile Leu Glu Lys Thr Pro Pro Glu Ile Thr Ile Pro Pro 
    290                 295                 300                 


Tyr Glu Ala Arg Thr Asn Thr Gly Met Glu Lys Asp Gln Ser Leu Leu 
305                 310                 315                 320 


Leu Asn Pro Glu Lys Leu Asn Asn Leu Tyr Pro Asn Trp Arg Asn Leu 
                325                 330                 335     


Ile Pro Gly Ile Ile Asp Ala His Pro Phe Leu Glu Lys Asp Leu Glu 
            340                 345                 350         


His Thr Lys Leu Arg Asp Arg Lys Arg Ile Ile Ser Pro Ser Lys Gln 
        355                 360                 365             


Asp Glu Lys Arg Asp Ser Tyr Ile Leu Gln Arg Tyr Leu Asp Leu Asn 
    370                 375                 380                 


Lys Lys Ile Asp Lys Phe Lys Ile Lys Lys Gln Leu Ser Phe Leu Gly 
385                 390                 395                 400 


Gln Gly Lys Gln Leu Pro Ala Asn Leu Ile Glu Thr Gln Lys Glu Met 
                405                 410                 415     


Glu Thr His Phe Asn Ser Ser Leu Val Ser Val Leu Ile Gln Ile Ala 
            420                 425                 430         


Ser Ala Tyr Asn Lys Glu Arg Glu Asp Ala Ala Gln Gly Ile Trp Phe 
        435                 440                 445             


Asp Asn Ala Phe Ser Leu Cys Glu Leu Ser Asn Ile Asn Pro Pro Arg 
    450                 455                 460                 


Lys Gln Lys Ile Leu Pro Leu Leu Val Gly Ala Ile Leu Ser Glu Asp 
465                 470                 475                 480 


Phe Ile Asn Asn Lys Asp Lys Trp Ala Lys Phe Lys Ile Phe Trp Asn 
                485                 490                 495     


Thr His Lys Ile Gly Arg Thr Ser Leu Lys Ser Lys Cys Lys Glu Ile 
            500                 505                 510         


Glu Glu Ala Arg Lys Asn Ser Gly Asn Ala Phe Lys Ile Asp Tyr Glu 
        515                 520                 525             


Glu Ala Leu Asn His Pro Glu His Ser Asn Asn Lys Ala Leu Ile Lys 
    530                 535                 540                 


Ile Ile Gln Thr Ile Pro Asp Ile Ile Gln Ala Ile Gln Ser His Leu 
545                 550                 555                 560 


Gly His Asn Asp Ser Gln Ala Leu Ile Tyr His Asn Pro Phe Ser Leu 
                565                 570                 575     


Ser Gln Leu Tyr Thr Ile Leu Glu Thr Lys Arg Asp Gly Phe His Lys 
            580                 585                 590         


Asn Cys Val Ala Val Thr Cys Glu Asn Tyr Trp Arg Ser Gln Lys Thr 
        595                 600                 605             


Glu Ile Asp Pro Glu Ile Ser Tyr Ala Ser Arg Leu Pro Ala Asp Ser 
    610                 615                 620                 


Val Arg Pro Phe Asp Gly Val Leu Ala Arg Met Met Gln Arg Leu Ala 
625                 630                 635                 640 


Tyr Glu Ile Ala Met Ala Lys Trp Glu Gln Ile Lys His Ile Pro Asp 
                645                 650                 655     


Asn Ser Ser Leu Leu Ile Pro Ile Tyr Leu Glu Gln Asn Arg Phe Glu 
            660                 665                 670         


Phe Glu Glu Ser Phe Lys Lys Ile Lys Gly Ser Ser Ser Asp Lys Thr 
        675                 680                 685             


Leu Glu Gln Ala Ile Glu Lys Gln Asn Ile Gln Trp Glu Glu Lys Phe 
    690                 695                 700                 


Gln Arg Ile Ile Asn Ala Ser Met Asn Ile Cys Pro Tyr Lys Gly Ala 
705                 710                 715                 720 


Ser Ile Gly Gly Gln Gly Glu Ile Asp His Ile Tyr Pro Arg Ser Leu 
                725                 730                 735     


Ser Lys Lys His Phe Gly Val Ile Phe Asn Ser Glu Val Asn Leu Ile 
            740                 745                 750         


Tyr Cys Ser Ser Gln Gly Asn Arg Glu Lys Lys Glu Glu His Tyr Leu 
        755                 760                 765             


Leu Glu His Leu Ser Pro Leu Tyr Leu Lys His Gln Phe Gly Thr Asp 
    770                 775                 780                 


Asn Val Ser Asp Ile Lys Asn Phe Ile Ser Gln Asn Val Ala Asn Ile 
785                 790                 795                 800 


Lys Lys Tyr Ile Ser Phe His Leu Leu Thr Pro Glu Gln Gln Lys Ala 
                805                 810                 815     


Ala Arg His Ala Leu Phe Leu Asp Tyr Asp Asp Glu Ala Phe Lys Thr 
            820                 825                 830         


Ile Thr Lys Phe Leu Met Ser Gln Gln Lys Ala Arg Val Asn Gly Thr 
        835                 840                 845             


Gln Lys Phe Leu Gly Lys Gln Ile Met Glu Phe Leu Ser Thr Leu Ala 
    850                 855                 860                 


Asp Ser Lys Gln Leu Gln Leu Glu Phe Ser Ile Lys Gln Ile Thr Ala 
865                 870                 875                 880 


Glu Glu Val His Asp His Arg Glu Leu Leu Ser Lys Gln Glu Pro Lys 
                885                 890                 895     


Leu Val Lys Ser Arg Gln Gln Ser Phe Pro Ser His Ala Ile Asp Ala 
            900                 905                 910         


Thr Leu Thr Met Ser Ile Gly Leu Lys Glu Phe Pro Gln Phe Ser Gln 
        915                 920                 925             


Glu Leu Asp Asn Ser Trp Phe Ile Asn His Leu Met Pro Asp Glu Val 
    930                 935                 940                 


His Leu Asn Pro Val Arg Ser Lys Glu Lys Tyr Asn Lys Pro Asn Ile 
945                 950                 955                 960 


Ser Ser Thr Pro Leu Phe Lys Asp Ser Leu Tyr Ala Glu Arg Phe Ile 
                965                 970                 975     


Pro Val Trp Val Lys Gly Glu Thr Phe Ala Ile Gly Phe Ser Glu Lys 
            980                 985                 990         


Asp Leu Phe Glu Ile Lys Pro Ser  Asn Lys Glu Lys Leu  Phe Thr Leu 
        995                 1000                 1005             


Leu Lys  Thr Tyr Ser Thr Lys  Asn Pro Gly Glu Ser  Leu Gln Glu 
    1010                 1015                 1020             


Leu Gln  Ala Lys Ser Lys Ala  Lys Trp Leu Tyr Phe  Pro Ile Asn 
    1025                 1030                 1035             


Lys Thr  Leu Ala Leu Glu Phe  Leu His His Tyr Phe  His Lys Glu 
    1040                 1045                 1050             


Ile Val  Thr Pro Asp Asp Thr  Thr Val Cys His Phe  Ile Asn Ser 
    1055                 1060                 1065             


Leu Arg  Tyr Tyr Thr Lys Lys  Glu Ser Ile Thr Val  Lys Ile Leu 
    1070                 1075                 1080             


Lys Glu  Pro Met Pro Val Leu  Ser Val Lys Phe Glu  Ser Ser Lys 
    1085                 1090                 1095             


Lys Asn  Val Leu Gly Ser Phe  Lys His Thr Ile Ala  Leu Pro Ala 
    1100                 1105                 1110             


Thr Lys  Asp Trp Glu Arg Leu  Phe Asn His Pro Asn  Phe Leu Ala 
    1115                 1120                 1125             


Leu Lys  Ala Asn Pro Ala Pro  Asn Pro Lys Glu Phe  Asn Glu Phe 
    1130                 1135                 1140             


Ile Arg  Lys Tyr Phe Leu Ser  Asp Asn Asn Pro Asn  Ser Asp Ile 
    1145                 1150                 1155             


Pro Asn  Asn Gly His Asn Ile  Lys Pro Gln Lys His  Lys Ala Val 
    1160                 1165                 1170             


Arg Lys  Val Phe Ser Leu Pro  Val Ile Pro Gly Asn  Ala Gly Thr 
    1175                 1180                 1185             


Met Met  Arg Ile Arg Arg Lys  Asp Asn Lys Gly Gln  Pro Leu Tyr 
    1190                 1195                 1200             


Gln Leu  Gln Thr Ile Asp Asp  Thr Pro Ser Met Gly  Ile Gln Ile 
    1205                 1210                 1215             


Asn Glu  Asp Arg Leu Val Lys  Gln Glu Val Leu Met  Asp Ala Tyr 
    1220                 1225                 1230             


Lys Thr  Arg Asn Leu Ser Thr  Ile Asp Gly Ile Asn  Asn Ser Glu 
    1235                 1240                 1245             


Gly Gln  Ala Tyr Ala Thr Phe  Asp Asn Trp Leu Thr  Leu Pro Val 
    1250                 1255                 1260             


Ser Thr  Phe Lys Pro Glu Ile  Ile Lys Leu Glu Met  Lys Pro His 
    1265                 1270                 1275             


Ser Lys  Thr Arg Arg Tyr Ile  Arg Ile Thr Gln Ser  Leu Ala Asp 
    1280                 1285                 1290             


Phe Ile  Lys Thr Ile Asp Glu  Ala Leu Met Ile Lys  Pro Ser Asp 
    1295                 1300                 1305             


Ser Ile  Asp Asp Pro Leu Asn  Met Pro Asn Glu Ile  Val Cys Lys 
    1310                 1315                 1320             


Asn Lys  Leu Phe Gly Asn Glu  Leu Lys Pro Arg Asp  Gly Lys Met 
    1325                 1330                 1335             


Lys Ile  Val Ser Thr Gly Lys  Ile Val Thr Tyr Glu  Phe Glu Ser 
    1340                 1345                 1350             


Asp Ser  Thr Pro Gln Trp Ile  Gln Thr Leu Tyr Val  Thr Gln Leu 
    1355                 1360                 1365             


Lys Lys  Gln Pro 
    1370         


<210> 305
<211> 1355
<212> PRT
<213> Leuconostoc gelidum


<220>
<223> Leuconostoc gelidum KCTC 3527

<400> 305
Met Thr Tyr Ser Ile Gly Leu Asp Ile Gly Thr Gly Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Ile Gly Asp Asp Tyr Arg Leu Lys Arg Ala Lys Gly Lys Asn 
            20                  25                  30          


Leu Ile Gly Val Arg Leu Phe Asp Ser Ala Thr Thr Ala Ala Glu Arg 
        35                  40                  45              


Arg Gly Tyr Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg His Trp Arg 
    50                  55                  60                  


Leu Arg Leu Leu Asn Asp Ile Phe Ala Ser Asp Leu Ala Glu Gln Asp 
65                  70                  75                  80  


Glu Asn Phe Leu Pro Arg Leu Lys Tyr Ser Trp Val Asn Pro Asp Asp 
                85                  90                  95      


Glu Gln Asn Pro Gln Leu Asn Ser Asp Val Ala Asn Gly Ala Leu Phe 
            100                 105                 110         


Gly Ser Ser Glu Thr Asp Lys Ala Phe His Lys Asn Tyr Pro Thr Ile 
        115                 120                 125             


Tyr His Leu Arg His Glu Leu Met Thr Asp Thr Ala Lys His Asp Leu 
    130                 135                 140                 


Arg Glu Val Tyr Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn 
145                 150                 155                 160 


Phe Leu Asn Thr Ala Asp Lys Ile Asn Ala Glu Asn Ser Phe Asn Val 
                165                 170                 175     


Asp Leu Phe Ile Ala Ala Leu Asp Glu Tyr Asn Glu Phe Leu Glu Thr 
            180                 185                 190         


Pro Ile Thr Ser Ile Lys Asp Ala Gln Leu Phe Ser Asp Lys Leu Thr 
        195                 200                 205             


Asp Ile Asn Ala Arg Asn Lys Ser Val Arg Val Glu Asn Ala Met Ser 
    210                 215                 220                 


Glu Thr Tyr Asp Asp Lys Ser Lys Ile Phe Lys Ala Ile Leu Thr Ala 
225                 230                 235                 240 


Leu Val Gly Asn Thr Ala Asn Phe Gln Thr Ile Phe Asp Leu Ser Asp 
                245                 250                 255     


Leu Glu Lys Asp Glu Ala Lys Asn Phe Lys Phe Lys Leu Asp Leu Glu 
            260                 265                 270         


Asp Val Glu Thr Lys Leu Asp Val Val Arg Ala Lys Leu Ser Asp Glu 
        275                 280                 285             


Gln Asn Ala Phe Leu Glu Ala Val Leu Ile Ala Tyr Asp Gly Ile Thr 
    290                 295                 300                 


Leu Lys Met Ile Leu Gly Asp Tyr Lys Ser Ile Ser Gln Ser Met Ile 
305                 310                 315                 320 


Glu Ser Tyr Lys Ser His Gln Arg Asp Trp Lys Tyr Ile Lys Asn Asn 
                325                 330                 335     


Val Arg Leu Asn Glu Gln Lys Ile Glu Pro Asp Lys Asn Ser Val Lys 
            340                 345                 350         


Phe Phe Lys Leu Asp Pro Lys Lys Leu Ile Tyr Pro Ser Asn Leu Ala 
        355                 360                 365             


Tyr Leu Gln Val Ile Ser Ser Asn Glu Asp Glu His Arg Lys Gly Leu 
    370                 375                 380                 


Asp Tyr Phe Lys Thr Ala Ile Gln Asp Ala Asp Ile Leu Gln Arg Ile 
385                 390                 395                 400 


Glu Asn Asp Thr Phe Leu Pro Arg Gln Arg Thr Lys Arg Asn Gly Val 
                405                 410                 415     


Leu Pro Tyr Gln Leu His Leu Ala Glu Leu Glu Gln Ile Ile Lys Lys 
            420                 425                 430         


Gln Ser Lys Tyr Tyr Pro Phe Leu Ala Asn Ile Tyr Thr Gln Asp Asn 
        435                 440                 445             


Lys Thr Glu Asn Lys Leu Ile Gly Leu Leu Lys Phe Arg Val Pro Tyr 
    450                 455                 460                 


Tyr Val Gly Pro Leu Val Glu Ala Glu Lys Val Thr Gly Asp Gly Lys 
465                 470                 475                 480 


Asn His Trp Leu Ile Lys Lys Glu Leu Gln Glu Asn Thr Pro Ile Thr 
                485                 490                 495     


Pro Phe Asn Phe Asp Asp Val Val Asp Lys Asp Lys Ser Gly Glu Gln 
            500                 505                 510         


Phe Ile Lys Arg Ile Thr Gly Thr Asp Ser Tyr Leu Ile Gly Glu Pro 
        515                 520                 525             


Thr Leu Pro Glu Asn Ser Leu Leu Tyr Gln Lys Tyr Asn Val Leu Gln 
    530                 535                 540                 


Glu Leu Asn Asn Val Arg Asn Glu Arg His Gln Arg Leu Pro Ile Lys 
545                 550                 555                 560 


Val Lys Gln Asp Ile Phe Glu His Val Phe Lys Ile Asp Lys Asn Val 
                565                 570                 575     


Asn Ala Lys Lys Val Met Ala Tyr Leu Lys Leu Asn Gly Tyr Gly Asp 
            580                 585                 590         


Phe Gln Ile Ala Gly Leu Ser Asp Thr Arg Thr Gly Lys Phe Asn Ser 
        595                 600                 605             


Asn Leu Ser Ser Tyr Asn Tyr Phe Val Asp Leu Leu Gly Arg Glu Lys 
    610                 615                 620                 


Thr Glu Lys Ile Arg Glu Asp Arg Leu Glu Glu Ile Ile Glu Ile Gln 
625                 630                 635                 640 


Thr Val Phe Glu Asp Lys Ile Leu Val Ala Lys Arg Leu Ser Asn Leu 
                645                 650                 655     


Asp Phe Leu Thr Pro Gln Glu Lys Ser Lys Leu Ser Ala Lys His Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Gln Lys Leu Leu Thr Thr Gln Phe Ile 
        675                 680                 685             


Lys Thr Ala Leu Ser Glu Ala Gly Asp Ile Ile Pro Gln Ser His Ser 
    690                 695                 700                 


Ile Ile Asp Leu Leu Tyr Tyr Thr Asp Lys Asn Leu Met Glu Ile Leu 
705                 710                 715                 720 


Asn Asp Lys Thr Phe Asn Val Arg Asn Trp Leu Thr Glu Gln Asn Lys 
                725                 730                 735     


Gly Thr Glu Ser Gly Asn Ser Leu Tyr Asp Gln Ile Asp Ala Leu Ala 
            740                 745                 750         


Gly Pro Lys Asp Ile Lys Arg Gly Ile Thr Gln Val Phe Ser Ile Ile 
        755                 760                 765             


Asp Asp Ile Lys Lys Ala Met Gly Ser Asn Pro Glu Thr Val Tyr Leu 
    770                 775                 780                 


Glu Phe Ala Arg Glu Thr Gln Thr Ser Arg Leu Thr Asn Ser Arg Leu 
785                 790                 795                 800 


Asn Arg Val Gln Glu Ile Tyr Asn Ser Pro Glu Leu Lys Thr Glu Phe 
                805                 810                 815     


Ala Tyr Leu Ala Lys Lys Leu Glu Ala Glu Thr Lys Glu Ser Ile His 
            820                 825                 830         


Asp Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Glu Gly Arg Asp Met Tyr 
        835                 840                 845             


Thr Gly Lys Glu Ile Pro Phe Asp Gln Ile Ser Ser Asn Tyr Asp Ile 
    850                 855                 860                 


Asp His Ile Ile Pro Gln Ala Phe Thr Lys Asp Asp Ser Leu Asp Asn 
865                 870                 875                 880 


Arg Val Leu Val Asn Arg Ala Thr Asn Ala Arg Lys Ser Asn Ser Pro 
                885                 890                 895     


Thr Phe Thr Asn Asp Ile Ile Asp Asn Arg Lys Ser Trp Trp Gln Ser 
            900                 905                 910         


Leu Val Lys Arg Gly Leu Met Ser Lys Glu Lys Phe Glu Arg Leu Thr 
        915                 920                 925             


Asp Lys Arg Lys Thr Phe Ser Glu Asn Gln Thr Asn His Phe Ile Ala 
    930                 935                 940                 


Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Lys Asn Val Ala Asp Leu 
945                 950                 955                 960 


Ile Lys Asn Asn Tyr Asp Gly Thr Gln Ala Val Ala Ile Arg Ala Ser 
                965                 970                 975     


Leu Thr Gly Glu Met Arg Arg Tyr Leu Asp Trp Pro Lys Asn Arg Asp 
            980                 985                 990         


Met Asn Asp Tyr His His Ala His  Asp Ala Leu Met Met  Ala Thr Val 
        995                 1000                 1005             


Gly Lys  Tyr Val Asp Arg Arg  Gly Phe Phe Asp Asn  Gly Ser Val 
    1010                 1015                 1020             


Ser Asp  Gly Ala Gly Asn Ala  Tyr Asn Leu Tyr Thr  Lys Asp Trp 
    1025                 1030                 1035             


Leu Val  Ala Ala Arg Val Gly  Thr Arg Asn Asp Ser  Gln Arg Val 
    1040                 1045                 1050             


Asn Pro  Tyr Gly Phe Ile Val  Gly Ser Met Asn Ser  Lys Ala Val 
    1055                 1060                 1065             


Arg Gln  Gln Val Asn Lys Glu  Thr Gly Glu Ile Val  Trp Gly Asn 
    1070                 1075                 1080             


Glu Asn  Leu Asp Tyr Leu Arg  His Val Leu Ser Tyr  Lys Lys Ile 
    1085                 1090                 1095             


Leu Val  Thr Arg Arg Leu Ser  Gly Ser Ser Gly Arg  Leu Tyr Ala 
    1100                 1105                 1110             


Glu Thr  Leu Phe Ser Pro Asn  Pro Lys Ala Lys Leu  Ile Ala Gln 
    1115                 1120                 1125             


Lys Ala  Asn Arg Ser Val Ala  Leu Tyr Gly Gly Phe  Thr Lys Ala 
    1130                 1135                 1140             


Glu Ser  Ala Tyr Thr Ala Leu  Val Glu Phe Asn Lys  Lys Gly Asp 
    1145                 1150                 1155             


Arg Ser  Tyr Lys Leu Ile Lys  Val Pro Met Ala Ile  Ala Asn Arg 
    1160                 1165                 1170             


Val Asn  Asp Lys Gln Ile Thr  Val Thr Ala Tyr Ile  Ala Ser Leu 
    1175                 1180                 1185             


Asn Leu  Arg Asp Phe Ser Arg  Val Val Leu Glu His  Leu Pro Leu 
    1190                 1195                 1200             


Gly Thr  Leu Ile Arg Glu Ser  Asp Gly Ser Glu Phe  Tyr Ala Ala 
    1205                 1210                 1215             


Ser Ser  Glu Tyr Lys His Asn  Ala Lys Glu Leu Trp  Ala Pro Lys 
    1220                 1225                 1230             


Glu Ile  Leu Arg Ser Ser Lys  Lys Leu Asp Lys Ala  Thr Ala Asp 
    1235                 1240                 1245             


Asn Leu  Ile Asp Ile Phe Asp  Phe Leu Thr Asn Asp  Lys Thr Ile 
    1250                 1255                 1260             


Ser Asn  Phe Lys Phe Tyr Glu  Lys Asp Leu Leu His  Leu Lys Asn 
    1265                 1270                 1275             


Val Arg  Asp Lys Phe Val Glu  Ala Ser Asp Glu Ile  Lys Ile Lys 
    1280                 1285                 1290             


Val Leu  Ser Asp Val Ile Tyr  Glu Leu His Asn Asp  Ala Gly Trp 
    1295                 1300                 1305             


Arg Asp  Pro Phe Lys His Ile  Gln Glu Lys Pro Ala  Trp Thr Met 
    1310                 1315                 1320             


Leu Gln  Val Lys Gly Gly Ile  Lys Leu Ser Glu Lys  Ala Ala Ile 
    1325                 1330                 1335             


Val Tyr  Gln Ser Pro Thr Gly  Leu Phe Glu Thr Ile  Thr Ile Val 
    1340                 1345                 1350             


Gly Glu  
    1355 


<210> 306
<211> 1337
<212> PRT
<213> Listeria innocua


<220>
<223> Listeria innocua ATCC 33091

<400> 306
Met Lys Asn Met Lys Lys Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr 
1               5                   10                  15      


Asn Ser Val Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys 
            20                  25                  30          


Arg Lys Met Lys Ile Ala Gly Asp Ser Glu Lys Lys Gln Ile Lys Lys 
        35                  40                  45              


Asn Phe Trp Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Ala Asp 
    50                  55                  60                  


Arg Arg Met Ala Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn 
65                  70                  75                  80  


Arg Ile Ser Tyr Leu Gln Gly Ile Phe Ala Glu Glu Met Ser Lys Thr 
                85                  90                  95      


Asp Ala Asn Phe Phe Cys Arg Leu Ser Asp Ser Phe Tyr Val Asp Asn 
            100                 105                 110         


Glu Lys Arg Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu 
        115                 120                 125             


Val Glu Tyr His Lys Asn Tyr Pro Thr Ile Tyr His Leu Arg Glu Glu 
    130                 135                 140                 


Leu Val Asn Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala 
145                 150                 155                 160 


Leu Ala His Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala 
                165                 170                 175     


Leu Asp Thr Gln Asn Thr Ser Val Asp Gly Ile Tyr Lys Gln Phe Ile 
            180                 185                 190         


Gln Thr Tyr Asn Gln Val Phe Ala Ser Gly Ile Glu Asp Gly Ser Leu 
        195                 200                 205             


Lys Lys Leu Glu Asp Asn Lys Asp Val Ala Lys Ile Leu Val Glu Lys 
    210                 215                 220                 


Val Thr Arg Lys Glu Lys Leu Glu Arg Ile Leu Lys Leu Tyr Pro Gly 
225                 230                 235                 240 


Glu Lys Ser Ala Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly 
                245                 250                 255     


Ser Lys Gly Asn Phe Gln Lys Pro Phe Asp Leu Ile Glu Lys Ser Asp 
            260                 265                 270         


Ile Glu Cys Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ser Leu Leu 
        275                 280                 285             


Ala Leu Ile Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn 
    290                 295                 300                 


Ala Tyr Ser Ala Val Val Leu Ser Ser Ile Ile Thr Val Ala Glu Thr 
305                 310                 315                 320 


Glu Thr Asn Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Thr 
                325                 330                 335     


His Glu Glu Asp Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu 
            340                 345                 350         


Pro Lys His Tyr Glu Glu Ile Phe Ser Asn Thr Glu Lys His Gly Tyr 
        355                 360                 365             


Ala Gly Tyr Ile Asp Gly Lys Thr Lys Gln Ala Asp Phe Tyr Lys Tyr 
    370                 375                 380                 


Met Lys Met Thr Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala 
385                 390                 395                 400 


Lys Ile Glu Lys Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn 
                405                 410                 415     


Gly Ala Ile Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu 
            420                 425                 430         


His Gln Gln Ala Lys Tyr Tyr Pro Phe Leu Lys Glu Asn Tyr Asp Lys 
        435                 440                 445             


Ile Lys Ser Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu 
    450                 455                 460                 


Ala Asn Gly Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly 
465                 470                 475                 480 


Glu Ile Arg Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser 
                485                 490                 495     


Ala Val Asp Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro 
            500                 505                 510         


Lys Glu Asn Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Leu 
        515                 520                 525             


Val Tyr Asn Glu Leu Thr Lys Val Arg Tyr Ile Asn Asp Gln Gly Lys 
    530                 535                 540                 


Thr Ser Tyr Phe Ser Gly Gln Glu Lys Glu Gln Ile Phe Asn Asp Leu 
545                 550                 555                 560 


Phe Lys Gln Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu 
                565                 570                 575     


Arg Asn Met Ser His Val Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp 
            580                 585                 590         


Ser Phe Asn Ser Ser Tyr Ser Thr Tyr His Asp Leu Leu Lys Val Gly 
        595                 600                 605             


Ile Lys Gln Glu Ile Leu Asp Asn Pro Val Asn Thr Glu Met Leu Glu 
    610                 615                 620                 


Asn Ile Val Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys 
625                 630                 635                 640 


Glu Gln Leu Gln Gln Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys 
                645                 650                 655     


Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys 
            660                 665                 670         


Leu Leu Met Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp 
        675                 680                 685             


Tyr Leu Met Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile 
    690                 695                 700                 


Asn Asp Ser Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val 
705                 710                 715                 720 


Thr Thr Ala Asp Lys Asp Ile Gln Ser Ile Val Ala Asp Leu Ala Gly 
                725                 730                 735     


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp 
            740                 745                 750         


Glu Leu Val Ser Val Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu 
        755                 760                 765             


Met Ala Arg Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Arg 
    770                 775                 780                 


Pro Arg Tyr Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln 
785                 790                 795                 800 


Ile Leu Lys Glu His Pro Thr Asp Asn Gln Glu Leu Arg Asn Asn Arg 
                805                 810                 815     


Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln 
            820                 825                 830         


Asp Leu Asp Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val 
        835                 840                 845             


Pro Gln Ser Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr 
    850                 855                 860                 


Ser Ser Ala Gly Asn Arg Glu Lys Gly Asp Asp Val Pro Pro Leu Glu 
865                 870                 875                 880 


Ile Val Arg Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn 
                885                 890                 895     


Leu Met Ser Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly 
            900                 905                 910         


Gly Leu Thr Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val 
        915                 920                 925             


Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg 
    930                 935                 940                 


Phe Asn Tyr Glu Lys Asp Asp His Gly Asn Thr Met Lys Gln Val Arg 
945                 950                 955                 960 


Ile Val Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe 
                965                 970                 975     


Gln Leu Tyr Lys Val Arg Asp Val Asn Asp Tyr His His Ala His Asp 
            980                 985                 990         


Ala Tyr Leu Asn Gly Val Val Ala  Asn Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Gln Leu  Glu Pro Glu Phe Val  Tyr Gly Asp Tyr His  Gln Phe Asp 
    1010                 1015                 1020             


Trp Phe  Lys Ala Asn Lys Ala  Thr Ala Lys Lys Gln  Phe Tyr Thr 
    1025                 1030                 1035             


Asn Ile  Met Leu Phe Phe Ala  Gln Lys Asp Arg Ile  Ile Asp Glu 
    1040                 1045                 1050             


Asn Gly  Glu Ile Leu Trp Asp  Lys Lys Tyr Leu Asp  Thr Val Lys 
    1055                 1060                 1065             


Lys Val  Met Ser Tyr Arg Gln  Met Asn Ile Val Lys  Lys Thr Glu 
    1070                 1075                 1080             


Ile Gln  Lys Gly Glu Phe Ser  Lys Ala Thr Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Asn Ser  Ser Lys Leu Ile Ser  Arg Lys Thr Asn Trp  Asp Pro Met 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Leu Asp Ser  Pro Asn Met Ala Tyr  Ala Val Val 
    1115                 1120                 1125             


Ile Glu  Tyr Ala Lys Gly Lys  Asn Lys Leu Val Phe  Glu Lys Lys 
    1130                 1135                 1140             


Ile Ile  Arg Val Thr Ile Met  Glu Arg Lys Ala Phe  Glu Lys Asp 
    1145                 1150                 1155             


Glu Lys  Ala Phe Leu Glu Glu  Gln Gly Tyr Arg Gln  Pro Lys Val 
    1160                 1165                 1170             


Leu Ala  Lys Leu Pro Lys Tyr  Thr Leu Tyr Glu Cys  Glu Glu Gly 
    1175                 1180                 1185             


Arg Arg  Arg Met Leu Ala Ser  Ala Asn Glu Ala Gln  Lys Gly Asn 
    1190                 1195                 1200             


Gln Gln  Val Leu Pro Asn His  Leu Val Thr Leu Leu  His His Val 
    1205                 1210                 1215             


Ala Asn  Cys Glu Val Ser Asp  Gly Lys Ser Leu Asp  Tyr Ile Glu 
    1220                 1225                 1230             


Ser Asn  Arg Glu Met Phe Ala  Glu Leu Leu Ala His  Val Ser Glu 
    1235                 1240                 1245             


Phe Ala  Lys Arg Tyr Thr Leu  Ala Glu Ala Asn Leu  Asn Lys Ile 
    1250                 1255                 1260             


Asn Gln  Leu Phe Glu Gln Asn  Lys Glu Gly Asp Ile  Lys Ala Ile 
    1265                 1270                 1275             


Ala Gln  Ser Phe Val Asp Leu  Met Ala Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ala  Ser Phe Lys Phe Phe  Glu Thr Thr Ile Glu  Arg Lys Arg 
    1295                 1300                 1305             


Tyr Asn  Asn Leu Lys Glu Leu  Leu Asn Ser Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Ile  Thr Gly Leu Tyr Glu  Ser Arg Lys Arg Leu  Asp Asp 
    1325                 1330                 1335         


<210> 307
<211> 1334
<212> PRT
<213> Listeria innocua

<400> 307
Met Lys Lys Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Ile Ala Gly Asp Ser Glu Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Ala Asp Arg Arg Met 
    50                  55                  60                  


Ala Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Gly Ile Phe Ala Glu Glu Met Ser Lys Thr Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Ser Asp Ser Phe Tyr Val Asp Asn Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Glu Tyr 
        115                 120                 125             


His Lys Asn Tyr Pro Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Gln Asn Thr Ser Val Asp Gly Ile Tyr Lys Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Ala Ser Gly Ile Glu Asp Gly Ser Leu Lys Lys Leu 
        195                 200                 205             


Glu Asp Asn Lys Asp Val Ala Lys Ile Leu Val Glu Lys Val Thr Arg 
    210                 215                 220                 


Lys Glu Lys Leu Glu Arg Ile Leu Lys Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Ala Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Pro Phe Asp Leu Ile Glu Lys Ser Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ser Leu Leu Ala Leu Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Ala Tyr Ser 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Ala Glu Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Thr His Glu Glu 
                325                 330                 335     


Asp Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys His 
            340                 345                 350         


Tyr Glu Glu Ile Phe Ser Asn Thr Glu Lys His Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Ala Asp Phe Tyr Lys Tyr Met Lys Met 
    370                 375                 380                 


Thr Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Lys Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Lys Glu Asn Tyr Asp Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Leu Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Ile Asn Asp Gln Gly Lys Thr Ser Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Glu Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Met 
                565                 570                 575     


Ser His Val Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ser Ser Tyr Ser Thr Tyr His Asp Leu Leu Lys Val Gly Ile Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Val Asn Thr Glu Met Leu Glu Asn Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Met 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Thr Thr Ala 
705                 710                 715                 720 


Asp Lys Asp Ile Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Val Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Arg Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Arg Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Asp Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Asp Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Tyr 
    930                 935                 940                 


Glu Lys Asp Asp His Gly Asn Thr Met Lys Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Asp Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Asp  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Asp Thr Val Lys  Lys Val Met 
    1055                 1060                 1065             


Ser Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Thr  Asn Trp Asp Pro Met  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Val  Ile Glu Tyr 
    1115                 1120                 1125             


Ala Lys  Gly Lys Asn Lys Leu  Val Phe Glu Lys Lys  Ile Ile Arg 
    1130                 1135                 1140             


Val Thr  Ile Met Glu Arg Lys  Ala Phe Glu Lys Asp  Glu Lys Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Gln Gly Tyr  Arg Gln Pro Lys Val  Leu Ala Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Glu Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ala Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Gln Val 
    1190                 1195                 1200             


Leu Pro  Asn His Leu Val Thr  Leu Leu His His Ala  Ala Asn Cys 
    1205                 1210                 1215             


Glu Val  Ser Asp Gly Lys Ser  Leu Asp Tyr Ile Glu  Ser Asn Arg 
    1220                 1225                 1230             


Glu Met  Phe Ala Glu Leu Leu  Ala His Val Ser Glu  Phe Ala Lys 
    1235                 1240                 1245             


Arg Tyr  Thr Leu Ala Glu Ala  Asn Leu Asn Lys Ile  Asn Gln Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Glu Gly  Asp Ile Lys Ala Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asp Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Thr Thr  Ile Glu Arg Lys Arg  Tyr Asn Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Asn Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210> 308
<211> 1334
<212> PRT
<213> Listeria monocytogenes

<400> 308
Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asn Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Ser Asp Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Asp Gly Gln Thr Ala Val Asp Arg Arg Met 
    50                  55                  60                  


Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Val Glu Met Ala Asn Ile Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Lys Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Val Asp Gly Val Tyr Glu Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Met Ser Asn Ile Glu Glu Gly Thr Leu Ala Lys Val 
        195                 200                 205             


Glu Glu Asn Ile Glu Val Ala Asn Ile Leu Ala Gly Lys Phe Thr Arg 
    210                 215                 220                 


Arg Glu Lys Phe Glu Arg Ile Leu Gln Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Thr Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Val Phe Asp Leu Ile Glu Lys Thr Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ala Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Ala Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 
                325                 330                 335     


Asp Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys Gln 
            340                 345                 350         


Tyr Gln Glu Ile Phe Asn Asn Ala Ala Ile Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Val Asp Phe Tyr Lys Tyr Leu Lys Thr 
    370                 375                 380                 


Ile Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Ile His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Asp Tyr Glu Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Lys Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Gln Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 
                565                 570                 575     


Asn His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Met Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Met Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Pro Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Gly Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Glu Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Thr 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Ile Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Lys Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Gly Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Asp Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Asn 
    930                 935                 940                 


Glu Thr Asp Asn His Gly Asn Thr Met Glu Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Gly Gln Lys Glu  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Glu Thr Ile Lys  Lys Val Leu 
    1055                 1060                 1065             


Asp Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Glu  Asn Trp Asp Pro Met  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Ile  Ile Glu His 
    1115                 1120                 1125             


Ala Lys  Gly Lys Lys Lys Leu  Ile Phe Glu Lys Lys  Ile Ile Arg 
    1130                 1135                 1140             


Ile Thr  Ile Met Glu Arg Lys  Met Phe Glu Lys Asp  Glu Glu Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Lys Gly Tyr  Arg His Pro Lys Val  Leu Thr Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Lys Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ala Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Leu Val 
    1190                 1195                 1200             


Leu Ser  Asn His Leu Val Ser  Leu Leu Tyr His Ala  Lys Asn Cys 
    1205                 1210                 1215             


Glu Ala  Ser Asp Gly Lys Ser  Leu Lys Tyr Ile Glu  Ala His Arg 
    1220                 1225                 1230             


Glu Thr  Phe Ser Glu Leu Leu  Ala Gln Val Ser Glu  Phe Ala Thr 
    1235                 1240                 1245             


Arg Tyr  Thr Leu Ala Asp Ala  Asn Leu Ser Lys Ile  Asn Asn Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Glu Gly  Asp Ile Gln Ala Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asp Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Ala Thr  Ile Asp Arg Lys Arg  Tyr Thr Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Ser Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210> 309
<211> 1334
<212> PRT
<213> Listeria monocytogenes


<220>
<223> Listeria monocytogenes FSL J1-194

<400> 309
Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Ser Asp Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Asp Gly Gln Thr Ala Val Asp Arg Arg Met 
    50                  55                  60                  


Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Val Glu Met Ala Asn Ile Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Lys Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Val Asp Glu Val Tyr Lys Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Met Ser Asn Ile Glu Glu Gly Ala Leu Ala Lys Val 
        195                 200                 205             


Glu Glu Asn Thr Glu Val Ala Ser Ile Leu Ala Gly Lys Phe Thr Arg 
    210                 215                 220                 


Arg Glu Lys Phe Glu Arg Ile Leu Arg Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Thr Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Asn Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Val Phe Asn Leu Val Glu Lys Thr Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ala Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Ala Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 
                325                 330                 335     


Glu Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys Gln 
            340                 345                 350         


Tyr Gln Glu Ile Phe Asn Asn Ala Glu Ile Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Val Asp Phe Tyr Lys Tyr Leu Lys Thr 
    370                 375                 380                 


Thr Leu Glu Asn Val Glu Gly Ala Asp Tyr Phe Ile Thr Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Gly Tyr Asp Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Asp Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Ile Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Arg Glu Lys Gln Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 
                565                 570                 575     


Asn His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Leu Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Ile Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Glu Gln Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Thr 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Ile Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Asp Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Ile Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Gly Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Lys 
    930                 935                 940                 


Glu Thr Asp Asn His Gly Asn Thr Met Glu Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Glu  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Glu Thr Ile Lys  Lys Val Leu 
    1055                 1060                 1065             


Asp Tyr  Arg Gln Ile Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Glu  Asn Trp Asp Pro Met  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Ile  Ile Glu His 
    1115                 1120                 1125             


Ala Lys  Gly Lys Lys Lys Ile  Val Ile Glu Lys Lys  Leu Ile Gln 
    1130                 1135                 1140             


Ile Asn  Ile Met Glu Arg Lys  Met Phe Glu Lys Asp  Glu Glu Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Lys Gly Tyr  His Gln Pro Lys Val  Leu Thr Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Lys Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ser Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Leu Val 
    1190                 1195                 1200             


Leu Ser  Asn His Leu Val Ser  Leu Leu Tyr His Ala  Lys Asn Cys 
    1205                 1210                 1215             


Glu Ala  Ser Asp Gly Lys Ser  Leu Lys Tyr Ile Glu  Ala His Arg 
    1220                 1225                 1230             


Glu Thr  Phe Ser Glu Leu Leu  Ala Gln Val Ser Glu  Phe Ala Thr 
    1235                 1240                 1245             


Lys Tyr  Thr Leu Ala Asp Ala  Asn Leu Ser Lys Ile  Asn Asn Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Glu Gly  Asp Ile Lys Ala Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asp Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Ala Thr  Ile Asp Arg Lys Arg  Tyr Thr Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Ser Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210> 310
<211> 1334
<212> PRT
<213> Listeria monocytogenes


<220>
<223> Listeria monocytogenes FSL J1-208

<400> 310
Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Ser Asp Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Glu Thr Ala Ala Asp Arg Arg Met 
    50                  55                  60                  


Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Leu Glu Met Ala Asn Ile Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Lys Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Val Asp Gly Val Tyr Lys Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Ile Ser Asn Ile Glu Glu Gly Thr Leu Ala Lys Met 
        195                 200                 205             


Glu Glu Asn Thr Thr Val Ala Asp Ile Leu Ala Gly Lys Phe Thr Arg 
    210                 215                 220                 


Lys Glu Lys Leu Glu Arg Ile Leu Gln Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Thr Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Val Phe Asp Leu Val Glu Lys Thr Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ala Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Asp Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 
                325                 330                 335     


Asp Leu Ser Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys Gln 
            340                 345                 350         


Tyr Glu Glu Ile Phe Ser Asn Val Ala Ile Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Val Asp Phe Tyr Lys Tyr Leu Lys Thr 
    370                 375                 380                 


Leu Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Lys Glu Ala Tyr Asp Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Asp Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Tyr Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Gln Gln Ile Phe Asn Asp Tyr Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Ser Lys Lys Asp Leu Glu Gln Phe Leu Arg Asn Met 
                565                 570                 575     


Ser His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ser Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Ile Lys Gln 
        595                 600                 605             


Glu Val Leu Glu Asn Pro Leu Asn Thr Glu Met Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Ala Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Thr 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Ile Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Val Lys Gly Lys Asn Asn Ser Arg Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Arg Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Asp Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Phe Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Thr Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Asn 
    930                 935                 940                 


Glu Thr Asp Asn His Gly Asn Asn Met Glu Gln Val Arg Ile Val Met 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Glu  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Glu Thr Ile Lys  Lys Val Leu 
    1055                 1060                 1065             


Asp Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Glu  Asn Trp Asp Pro Met  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Ile  Ile Glu His 
    1115                 1120                 1125             


Ala Lys  Gly Lys Lys Lys Val  Val Phe Glu Lys Lys  Ile Ile Arg 
    1130                 1135                 1140             


Ile Thr  Ile Met Glu Arg Lys  Ala Phe Glu Lys Asp  Glu Lys Ser 
    1145                 1150                 1155             


Phe Leu  Glu Lys Gln Gly Tyr  Arg Gln Pro Lys Val  Leu Thr Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Asn Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ala Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Gln Val 
    1190                 1195                 1200             


Leu Lys  Gly Gln Leu Ile Thr  Leu Leu His His Ala  Lys Asn Cys 
    1205                 1210                 1215             


Glu Ala  Ser Asp Gly Lys Ser  Leu Asp Tyr Ile Glu  Ser Asn Arg 
    1220                 1225                 1230             


Glu Met  Phe Gly Glu Leu Leu  Ala His Val Ser Glu  Phe Ala Lys 
    1235                 1240                 1245             


Arg Tyr  Thr Leu Ala Asp Ala  Asn Leu Ser Lys Ile  Asn Gln Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Asp Asn  Asp Ile Lys Val Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asn Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Ala Thr  Ile Glu Arg Lys Arg  Tyr Thr Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Ser Ala  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ala Arg Lys  Arg Leu Asp Gly 
    1325                 1330                 


<210> 311
<211> 1334
<212> PRT
<213> Listeria monocytogenes


<220>
<223> Listeria monocytogenes FSL N3-165

<400> 311
Met Lys Lys Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Ile Ser Gly Asp Ser Glu Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Lys Gly Glu Thr Ala Ala Lys Arg Arg Met 
    50                  55                  60                  


Ser Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Ile Gln Met Asn Glu Val Asp Asp Asn 
                85                  90                  95      


Phe Phe Asn Arg Leu Lys Glu Ser Phe Tyr Ala Glu Ser Asp Lys Lys 
            100                 105                 110         


Tyr Asn Arg His Pro Phe Phe Gly Thr Val Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


Tyr Lys Asp Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ile Asp 
    130                 135                 140                 


Ser Gln Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Ile Asp Glu Met Phe Lys Gln Phe Leu Gln Ile Tyr 
            180                 185                 190         


Asn Gln Val Phe Ala Asn Asp Ile Glu Glu Ala Ser Leu Lys Lys Thr 
        195                 200                 205             


Glu Lys Asn Gln Glu Val Ala Gln Ile Leu Ala Glu Lys Phe Thr Arg 
    210                 215                 220                 


Lys Asp Lys Leu Asp Lys Ile Leu Ser Leu Tyr Pro Gly Glu Lys Thr 
225                 230                 235                 240 


Thr Gly Val Phe Ala Gln Phe Val Asn Ile Ile Val Gly Ser Thr Gly 
                245                 250                 255     


Lys Phe Lys Lys His Phe Asn Leu His Glu Lys Lys Asp Ile Asn Cys 
            260                 265                 270         


Ala Glu Asp Thr Tyr Asp Thr Asp Leu Glu Ser Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Phe Ala Glu Val Phe Val Ala Ala Lys Asn Ala Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Asn Ile Ile Thr Val Thr Asp Ser Thr Thr Arg 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Leu Ile Glu Arg Phe Glu Asn His Lys Glu 
                325                 330                 335     


Asp Leu Lys Lys Met Lys Arg Phe Val Arg Thr Tyr Leu Pro Glu Lys 
            340                 345                 350         


Tyr Asp Glu Ile Phe Asp Asp Thr Glu Lys His Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ser Gly Lys Thr Lys Gln Ala Asp Phe Tyr Lys Tyr Met Lys Ala 
    370                 375                 380                 


Thr Leu Glu Lys Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Asp Tyr Glu Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Lys Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Gln Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 
                565                 570                 575     


Asn Gln Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Met Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Met Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Thr Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Thr 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Glu Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Val Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Asn Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Val Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Asp Asn Val Pro Pro Leu Glu Ile Val Gln 
865                 870                 875                 880 


Lys Arg Lys Ile Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Tyr 
    930                 935                 940                 


Lys Thr Asp Gly Asn Lys Asp Thr Met Glu Thr Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Phe Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Gly  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Asp  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Arg Tyr  Leu Glu Thr Val Lys  Lys Val Leu 
    1055                 1060                 1065             


Gly Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Asn Val Thr  Pro Asn Pro Lys Gly  Lys Ser Asn 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Lys  Asp Trp Asp Pro Ile  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Phe  Asp Gly Ser Lys Met  Ala Tyr Ala Ile Ile  Ile Glu Tyr 
    1115                 1120                 1125             


Glu Lys  Gln Lys Arg Lys Val  Arg Ile Glu Lys Lys  Leu Ile Gln 
    1130                 1135                 1140             


Ile Asn  Ile Met Glu Arg Glu  Ala Phe Glu Lys Asp  Glu Lys Thr 
    1145                 1150                 1155             


Phe Leu  Glu Glu Lys Gly Tyr  His Gln Pro Lys Val  Leu Ile Lys 
    1160                 1165                 1170             


Val Pro  Lys Tyr Thr Leu Tyr  Glu Cys Lys Asn Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Gly Ser Ala Asn Glu  Ala His Lys Gly Asn  Gln Met Leu 
    1190                 1195                 1200             


Leu Pro  Asn His Leu Met Ala  Leu Leu Tyr His Ala  Glu Lys Tyr 
    1205                 1210                 1215             


Glu Ala  Ile Asp Gly Glu Ser  Leu Ala Tyr Ile Glu  Val His Arg 
    1220                 1225                 1230             


Ala Leu  Phe Asp Glu Leu Leu  Ala Tyr Ile Ser Glu  Phe Ala Arg 
    1235                 1240                 1245             


Lys Tyr  Thr Leu Ser Asn Asp  Arg Leu Asp Glu Ile  Asn Met Leu 
    1250                 1255                 1260             


Tyr Glu  Arg Asn Lys Asp Gly  Asp Val Lys Ser Ile  Ala Glu Ser 
    1265                 1270                 1275             


Phe Val  Ser Leu Lys Lys Phe  Asn Ala Phe Gly Val  His Gln Asp 
    1280                 1285                 1290             


Phe Ser  Phe Phe Gly Thr Lys  Ile Glu Arg Lys Arg  Asp Arg Lys 
    1295                 1300                 1305             


Leu Asn  Glu Leu Leu Asn Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asn 
    1325                 1330                 


<210> 312
<211> 1334
<212> PRT
<213> Listeria monocytogenes


<220>
<223> Listeria monocytogenes FSL R2-503

<400> 312
Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Ser Asp Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Asp Gly Gln Thr Ala Val Asp Arg Arg Met 
    50                  55                  60                  


Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Val Glu Met Ala Asn Ile Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Lys Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Val Asp Glu Val Tyr Lys Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Met Ser Asn Ile Glu Glu Gly Ala Leu Ala Lys Val 
        195                 200                 205             


Glu Glu Asn Thr Glu Val Ala Ser Ile Leu Ala Gly Lys Phe Thr Arg 
    210                 215                 220                 


Arg Glu Lys Phe Glu Arg Ile Leu Arg Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Thr Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Asn Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Val Phe Asn Leu Val Glu Lys Thr Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ala Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Ala Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 
                325                 330                 335     


Glu Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys Gln 
            340                 345                 350         


Tyr Gln Glu Ile Phe Asn Asn Ala Glu Ile Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Val Asp Phe Tyr Lys Tyr Leu Lys Thr 
    370                 375                 380                 


Thr Leu Glu Asn Val Glu Gly Ala Asp Tyr Phe Ile Thr Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Gly Tyr Asp Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Asp Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Ile Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Arg Glu Lys Gln Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 
                565                 570                 575     


Asn His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Leu Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Ile Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Glu Gln Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Thr 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Ile Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Asp Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Ile Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Gly Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Lys 
    930                 935                 940                 


Glu Thr Asp Asn His Gly Asn Thr Met Glu Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Glu  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Glu Thr Ile Lys  Lys Val Leu 
    1055                 1060                 1065             


Asp Tyr  Arg Gln Ile Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Glu  Asn Trp Asp Pro Val  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Ile  Ile Glu His 
    1115                 1120                 1125             


Ala Lys  Gly Lys Lys Lys Ile  Val Ile Glu Lys Lys  Leu Ile Gln 
    1130                 1135                 1140             


Ile Asn  Ile Met Glu Arg Lys  Met Phe Glu Lys Asp  Glu Glu Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Lys Gly Tyr  His Gln Pro Lys Val  Leu Thr Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Lys Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ser Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Leu Val 
    1190                 1195                 1200             


Leu Ser  Asn His Leu Val Ser  Leu Leu Tyr His Ala  Lys Asn Cys 
    1205                 1210                 1215             


Glu Ala  Ser Asp Gly Lys Ser  Leu Lys Tyr Ile Glu  Ala His Arg 
    1220                 1225                 1230             


Glu Thr  Phe Ser Glu Leu Leu  Ala Gln Val Ser Glu  Phe Ala Thr 
    1235                 1240                 1245             


Lys Tyr  Thr Leu Ala Asp Ala  Asn Leu Ser Lys Ile  Asn Asn Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Glu Gly  Asp Ile Lys Ala Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asp Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Ala Thr  Ile Asp Arg Lys Arg  Tyr Thr Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Ser Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210> 313
<211> 1334
<212> PRT
<213> Listeria monocytogenes


<220>
<223> Listeria monocytogenes serotype 1/2a str. F6854

<400> 313
Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asn Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Ser Asp Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Asp Gly Gln Thr Ala Val Asp Arg Arg Met 
    50                  55                  60                  


Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Val Glu Met Ala Asn Ile Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Asp Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Lys Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Val Asp Glu Val Tyr Lys Gln Phe Ile Glu Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Met Ser Asn Ile Glu Glu Gly Ala Leu Ala Lys Val 
        195                 200                 205             


Glu Glu Asn Ile Glu Val Ala Asn Ile Leu Ala Gly Lys Phe Thr Arg 
    210                 215                 220                 


Arg Glu Lys Phe Glu Arg Ile Leu Gln Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Thr Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Val Phe Asp Leu Ile Glu Lys Thr Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Thr Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Asp Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 
                325                 330                 335     


Asp Leu Val Glu Leu Lys Ala Phe Ile Lys Leu Asn Leu Pro Lys Gln 
            340                 345                 350         


Tyr Glu Glu Ile Phe Ser Asn Ala Ala Ile Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Val Asp Phe Tyr Lys Tyr Leu Lys Thr 
    370                 375                 380                 


Ile Leu Glu Asn Ile Glu Gly Ser Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Ile His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Lys Glu Asp Tyr Asp Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Ile Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Arg Glu Lys Gln Gln Val Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 
                565                 570                 575     


Asn His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Met Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Met Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Pro Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Gly Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Glu Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Thr 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Glu Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Ile Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Gly Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu Tyr Gln Arg Phe Asn Lys 
    930                 935                 940                 


Glu Thr Asp Asn His Gly Asn Thr Met Glu Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Gly Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Glu  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Glu Thr Ile Lys  Lys Val Leu 
    1055                 1060                 1065             


Asp Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Glu  Asn Trp Asp Pro Met  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Ile  Ile Glu His 
    1115                 1120                 1125             


Ala Lys  Gly Lys Lys Lys Ile  Val Ile Glu Lys Lys  Leu Ile Gln 
    1130                 1135                 1140             


Ile Asn  Ile Met Glu Arg Lys  Met Phe Glu Lys Asp  Glu Glu Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Lys Gly Tyr  Arg His Pro Lys Val  Leu Thr Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Lys Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ala Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Leu Val 
    1190                 1195                 1200             


Leu Ser  Asn His Leu Val Ser  Leu Leu Tyr His Ala  Lys Asn Cys 
    1205                 1210                 1215             


Glu Ala  Ser Asp Gly Lys Ser  Leu Lys Tyr Ile Glu  Ala His Arg 
    1220                 1225                 1230             


Glu Thr  Phe Ser Glu Leu Leu  Ala Gln Val Ser Glu  Phe Ala Thr 
    1235                 1240                 1245             


Arg Tyr  Thr Leu Ala Asp Ala  Asn Leu Ser Lys Ile  Asn Asn Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Glu Gly  Asp Ile Lys Ala Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asp Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Ala Thr  Ile Asp Arg Lys Arg  Tyr Thr Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Ser Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210> 314
<211> 1087
<212> PRT
<213> Listeriaceae bacterium


<220>
<223> Listeriaceae bacterium TTU M1-001

<400> 314
Met Lys Lys Leu Val Leu Gly Leu Asp Ile Gly Val Ala Ser Val Gly 
1               5                   10                  15      


Trp Gly Ile Ile Asp Ala Glu Asn Gly Asp Val Val Asp Thr Gly Val 
            20                  25                  30          


Arg Leu Phe Ser Ser Arg Asp Ala Ser Glu Asn Glu Ser Arg Arg Thr 
        35                  40                  45              


Ser Arg Gln Ser Arg Arg Leu Ser Arg Arg Lys Lys His Arg Arg Glu 
    50                  55                  60                  


Arg Ile Lys Gln Leu Leu Leu Ala His Asp Met Asp Ile Cys Asp Ile 
65                  70                  75                  80  


Val Asn Glu Asn Pro Tyr Glu Leu Arg Val Lys Gly Leu Asn Glu Lys 
                85                  90                  95      


Leu Glu Val Ser Glu Ile Tyr Val Ala Leu Thr His Leu Ala Lys Arg 
            100                 105                 110         


Arg Gly Val Ser Tyr Leu Asp Asp Val Val Glu Glu Gly Gly Thr Ile 
        115                 120                 125             


Lys Ser Glu His Leu Asn Lys Asn Met Glu Glu Ile Lys Ser Gly Lys 
    130                 135                 140                 


Met Pro Cys Glu Ile Gln Leu Glu Arg Phe Glu Lys Tyr Gly Gln Val 
145                 150                 155                 160 


Arg Gly Met Ile Glu Ile Asn Gln Asp Thr Glu Glu Ser Ser Phe Leu 
                165                 170                 175     


Val Asn Ile Phe Arg Thr Ser Asp Tyr Ile Lys Glu Ala Lys Thr Ile 
            180                 185                 190         


Leu Ala Thr Gln Gln Lys Phe His Lys Gln Ile Thr Asn Glu Phe Ile 
        195                 200                 205             


Asp Glu Tyr Ile His Ile Met Ala Ser Lys Arg Asp Tyr Phe Ile Gly 
    210                 215                 220                 


Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Val Tyr Arg Thr Asn 
225                 230                 235                 240 


Gly Asp Thr Trp Asp Asn Leu Phe Glu Ile Leu Ile Gly Lys Cys Ser 
                245                 250                 255     


Val Phe Pro Glu Glu Thr Arg Ala Ala Arg Ser Ser Tyr Val Ala Gln 
            260                 265                 270         


Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Lys Ile Ser Asn Leu 
        275                 280                 285             


Glu Ser Gly Lys Leu Ser Ala Ser Gln Lys His Asp Ile Val Glu Lys 
    290                 295                 300                 


Val Lys Asn Ser Lys Lys Phe Gly Thr Lys Asp Leu Leu Lys Tyr Ile 
305                 310                 315                 320 


Ala Ser Val Cys Glu Cys Lys Ile Glu Asp Ile Gly Gly Cys Arg Val 
                325                 330                 335     


Asp Lys Asn Arg Lys Pro Ile Met His Thr Phe Glu Asn Tyr Arg Lys 
            340                 345                 350         


Val His Asn Ala Leu Asn Glu Ala Gly Val Asp Leu Arg Leu Ser Glu 
        355                 360                 365             


Thr Asp Tyr Asp Glu Leu Met Lys Ile Met Thr Leu Asn Ser Glu Thr 
    370                 375                 380                 


Leu Glu Ile Lys Lys Gln Cys Lys Glu Lys Leu Pro Gln Leu Thr Glu 
385                 390                 395                 400 


Asp Tyr Leu Asn Val Cys Leu Val Leu Asn Lys Lys Gly Ala Phe Ser 
                405                 410                 415     


Gly Trp His Ala Leu Ser Leu Lys Ala Met Lys Leu Met Met Pro Glu 
            420                 425                 430         


Leu Tyr Gly Thr Ser Lys Asn Gln Met Gln Ile Ile His Thr Met Gln 
        435                 440                 445             


Leu Gly Lys Ala Tyr Leu Lys Pro Leu Asn Gln Gln Lys Tyr Leu Asn 
    450                 455                 460                 


Ser Glu Ala Ile Leu Glu Glu Ile Tyr Asn Pro Ile Ala Ala Arg Ser 
465                 470                 475                 480 


Ile Arg Gln Thr Ile Lys Val Thr Asn Ala Ile Leu Lys Lys Tyr Gly 
                485                 490                 495     


His Leu Asp Ser Val Ile Ile Glu Met Pro Arg Asp Tyr Gln Thr Ser 
            500                 505                 510         


Glu Asp Glu Arg Lys Met Ile Glu Lys Met Gln Lys Glu Asn Glu Lys 
        515                 520                 525             


Glu Lys Lys Ala Ala Leu Lys Arg Ala Arg Glu Glu Tyr Pro Phe Pro 
    530                 535                 540                 


Asp Glu Ala Phe Arg Asn His Lys Glu Leu Ala Thr Lys Leu Arg Leu 
545                 550                 555                 560 


Trp Tyr Gln Gln Asp Gln Phe Cys Val Tyr Ser Gly Arg Lys Ile Ser 
                565                 570                 575     


Val Val Asp Leu Val Arg Asn Pro Asn Gln Phe Glu Ile Asp His Ile 
            580                 585                 590         


Ile Pro Gln Ser Val Ser Leu Asp Asp Ser Leu Asn Asn Lys Val Leu 
        595                 600                 605             


Cys Phe Ser Glu Glu Asn Gln Lys Lys Gly Gln Gln Thr Pro Phe Tyr 
    610                 615                 620                 


Tyr His Lys Gly Lys Ser Gly Asn Trp Thr Tyr Glu Gln Tyr Lys Leu 
625                 630                 635                 640 


Phe Val Glu Lys Leu Phe Asp Lys Lys Lys Ile Ser Asn Lys Lys Arg 
                645                 650                 655     


Glu Leu Leu Leu Phe Glu Glu Asp Ile Asn Lys Trp Asp Val Arg Arg 
            660                 665                 670         


Gly Phe Ile Ala Arg Asn Leu Val Asp Thr Arg Tyr Ala Ser Arg Val 
        675                 680                 685             


Ile Leu Asn Ser Tyr Gln Gln Tyr Phe Gly Asn His Glu Met Gly Thr 
    690                 695                 700                 


Lys Val Lys Val Val Arg Gly Lys Phe Thr Ser Gln Leu Arg Lys Lys 
705                 710                 715                 720 


Trp Arg Ile Phe Lys Asp Arg Asn Glu Ser His Ser His His Ala Ile 
                725                 730                 735     


Asp Ala Leu Ile Val Ala Ala Thr Ala Asn Leu Arg Leu Trp Lys Lys 
            740                 745                 750         


Asn Thr Leu Gly Val Ser Asp Glu Gly Lys Val Tyr Asp Lys Glu Thr 
        755                 760                 765             


Gly Glu Ile Leu Pro Phe Glu Lys Leu Thr Glu Ser Glu Tyr Asn Glu 
    770                 775                 780                 


Met Met Asn Lys Glu Pro Tyr Leu Asn Phe Lys Thr Lys Leu Gln Asn 
785                 790                 795                 800 


Ile Glu Thr Lys Val Lys Tyr Ser Tyr Arg Val Ser Lys Lys Val Asn 
                805                 810                 815     


Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ser Thr Arg Glu Arg Asp Gly 
            820                 825                 830         


Ile Asp Tyr Ile Val Gly Lys Ile Lys Asn Ile Tyr Asp Val Lys Thr 
        835                 840                 845             


Tyr Lys Asp Gln Phe Leu Lys Arg Tyr Lys Lys Asn Lys Glu Gln Phe 
    850                 855                 860                 


Leu Met Tyr Gln His Asp Pro Gln Thr Phe Ala Ile Leu Glu Asn Ile 
865                 870                 875                 880 


Met Ala Thr Tyr Gln Asp Ala Glu Asn Pro Phe Leu Ala Tyr Lys Lys 
                885                 890                 895     


Glu Tyr Gly Val Ile Arg Lys Tyr Ser Lys Lys Gly Gly Gly Ser Pro 
            900                 905                 910         


Val Thr Ser Leu Lys Phe Ile Asp Lys Val Leu Gly Gln Lys Ile Asp 
        915                 920                 925             


Leu Thr Ala Lys Asn Gln Ala Ala Leu Pro Lys Asn Lys Lys Val Val 
    930                 935                 940                 


Leu Gln Ser Ile Thr Pro Tyr Arg Ala Asp Val Tyr Tyr Asp Glu Ile 
945                 950                 955                 960 


Asp Lys Arg Tyr His Leu Ile Gly Val Lys Tyr Ser Leu Phe Ser Phe 
                965                 970                 975     


Ser Lys Gln Gly Tyr Val Ile Asn Pro Ile Ala Tyr Gln Lys Leu Leu 
            980                 985                 990         


Glu Lys Glu Gln Ile His Ser Glu  Met Lys Phe Cys Phe  Ser Leu Tyr 
        995                 1000                 1005             


Arg Glu  Asp Ile Ile Glu Phe  Gly Glu Asp Pro Asp  Ser Leu Thr 
    1010                 1015                 1020             


Arg Tyr  Arg Phe Trp Ser Lys  Asn Glu Ser Gly Lys  Asn Lys Ile 
    1025                 1030                 1035             


Glu Val  Lys Pro Ile Glu Lys  Pro Asn Phe Glu Lys  Gln Thr Val 
    1040                 1045                 1050             


Leu Thr  Ile Thr Lys Lys Ile  Lys Ile Leu Asn Lys  Tyr Gln Thr 
    1055                 1060                 1065             


Asp Val  Leu Gly Asn Ser Phe  Lys Ala Gln Glu Glu  Lys Asp Pro 
    1070                 1075                 1080             


Arg Asn  Ile Glu 
    1085         


<210> 315
<211> 1345
<212> PRT
<213> Marinilabilia sp.


<220>
<223> Marinilabilia sp. AK2

<400> 315
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ile Lys Glu Pro Glu Lys Asp Val Val Gly Ser Glu Ile Val 
            20                  25                  30          


Asp Met Gly Val Arg Ile Val Ala Leu Ser Ser Asp Glu Glu Asn Asp 
        35                  40                  45              


Phe Ala Lys Gly Asn Thr Ile Ser Ile Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Ala Arg Arg Asn Leu Gln Arg Phe Lys Leu Arg Arg Asp Ala 
65                  70                  75                  80  


Leu Leu Glu Ile Phe Lys Glu Met Lys Leu Ile Pro Ser Asn Phe Lys 
                85                  90                  95      


Tyr Ala Glu Asp Gly Pro Ser Ser Thr Phe Ser Thr Leu Lys Leu Arg 
            100                 105                 110         


Asp Lys Ala Ala Lys Glu Lys Ile Glu Leu Asp Asp Leu Val Lys Val 
        115                 120                 125             


Leu Leu Gln Ile Asn Lys Lys Arg Gly Tyr Arg Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Ser Glu Glu Asp Asp Gly Ser Ala Ile Asp Ser Met Gly Ile Ala 
145                 150                 155                 160 


Lys Glu Leu Tyr Glu Asn Asp Leu Thr Pro Gly Gln Trp Val Phe Glu 
                165                 170                 175     


Ala Leu Gln Lys Gly Arg Lys Asn Val Pro Asp Phe Tyr Arg Ser Asp 
            180                 185                 190         


Leu Gln Glu Glu Phe Lys Lys Ile Val Asn Tyr Gln Ser Glu Phe Tyr 
        195                 200                 205             


Pro Asp Val Leu Asn Ser Ser Phe Val Glu Asp Trp Met Gly Lys Ala 
    210                 215                 220                 


Ser Thr Pro Thr Lys Gln Tyr Phe Asn Lys Lys Gly Val His Leu Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Lys Arg Glu Glu Arg Arg Leu Gln Glu Tyr Asn Trp 
                245                 250                 255     


Arg Ala Val Ala Val Asn Ser Lys Ile Asp Leu Ser Glu Ile Ala Leu 
            260                 265                 270         


Ile Leu Ser Gln Ile Asn Ser Gln Ile Ser Asn Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Lys Asn Gln Thr 
    290                 295                 300                 


Val Gly Gln Tyr Leu Tyr Gln Gln Ile Lys Ile Asn Pro His Thr Arg 
305                 310                 315                 320 


Leu Lys Gly Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Lys Ile Trp Ser Val Gln Ser Gly Phe His Pro Gln Leu Asn Asp Ala 
            340                 345                 350         


Leu Lys Lys Glu Ile Arg Asp Ile Thr Ile Phe Phe Gln Arg Arg Leu 
        355                 360                 365             


Lys Ser Gln Lys His Leu Ile Ser Asn Cys Glu Phe Glu Asp Tyr His 
    370                 375                 380                 


Lys Val Val Pro Lys Ser His Pro Ile Phe Gln Glu Phe Arg Ile Trp 
385                 390                 395                 400 


Gln Asn Leu Asn Asn Leu Thr Leu Ile Lys Lys Asp Asn Leu Asn Glu 
                405                 410                 415     


Lys Ser Glu Leu Ala Leu Glu Asp Lys Ile Ala Leu Ala Asn Glu Leu 
            420                 425                 430         


Ala Phe Lys Arg Glu Gln Ser Val Lys Asp Ala Leu Asn Ile Leu Gly 
        435                 440                 445             


Leu Lys Ser Ser Glu Trp Glu Phe Asn Phe Thr Lys Ile Glu Gly Asn 
    450                 455                 460                 


Arg Thr Asn His Ala Phe Phe Glu Ala Phe Ala Lys Ile Ile Glu Ile 
465                 470                 475                 480 


Glu Asp Gly Glu Pro Leu Asp Leu Gly Asn Leu Lys Ala Asp Asp Ile 
                485                 490                 495     


Leu Asp Gln Phe Ser Glu Ala Phe Leu Arg Ile Gly Ile Asp Pro Gly 
            500                 505                 510         


Leu Leu Gln Val Asn Asn Asp Ile Glu Gly Pro Asn Tyr Glu Lys Gln 
        515                 520                 525             


Pro Tyr Ile Gln Phe Trp His Leu Leu Tyr Ser Ser Glu Asp Asp Gln 
    530                 535                 540                 


Lys Leu Lys Gln Asn Leu Ile Lys Lys Phe Gly Phe Lys Pro Asp His 
545                 550                 555                 560 


Ala Lys Ile Leu Ala Ser Ile Ser Leu Gln Asp Asp His Ala Ser Leu 
                565                 570                 575     


Ser Ser Arg Ala Ile Lys Lys Ile Leu Pro His Leu Gln Ser Gly Leu 
            580                 585                 590         


Ile Tyr Asp Lys Ala Cys Thr Tyr Ala Gly Tyr Asn His Ser Ser Ser 
        595                 600                 605             


Phe Thr Lys Glu Glu Asn Glu Lys Arg Glu Leu Ser Ser Glu Leu Asp 
    610                 615                 620                 


Leu Leu Lys Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Leu 
625                 630                 635                 640 


Asn Gln Met Ile Asn Val Val Asn Ala Ile Leu Lys Asp Pro Asn Leu 
                645                 650                 655     


Gly Lys Pro Asp Glu Ile Arg Val Glu Met Ala Arg Glu Leu Lys Ala 
            660                 665                 670         


Asn Ala Glu Gln Arg Lys Asn Met Thr Ser Asn Ile Ala Ser Ala Thr 
        675                 680                 685             


Arg Asp His Glu Lys Tyr Arg Glu Ile Leu Lys Lys Glu Phe Gly Leu 
    690                 695                 700                 


Lys Arg Val Thr Lys Asn Asp Leu Leu Arg Tyr Lys Leu Trp Leu Glu 
705                 710                 715                 720 


Thr Asp Gly Ile Ser Leu Tyr Thr Gly Lys Pro Ile Glu Ala Ser Lys 
                725                 730                 735     


Leu Phe Ser Lys Glu Tyr Asp Ile Glu His Ile Ile Pro Lys Thr Arg 
            740                 745                 750         


Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Ile Cys Glu Arg Gln Leu 
        755                 760                 765             


Asn Ile Asp Lys Ala Asn Val Thr Ala Phe Ser Phe Leu Gln Asn Lys 
    770                 775                 780                 


Leu Ser Gly Asp Glu Phe Glu Gln Tyr Gln Ser Arg Val Lys Ser Leu 
785                 790                 795                 800 


Phe Gly Lys Leu Ser Lys Ala Lys Ile Gln Lys Leu Leu Met Ala Asn 
                805                 810                 815     


Asp Lys Ile Pro Glu Asp Phe Ile Ala Arg Gln Leu Gln Glu Thr Arg 
            820                 825                 830         


Tyr Ile Ser Lys Lys Ala Lys Glu Ile Leu Phe Glu Ile Thr Arg Arg 
        835                 840                 845             


Val Ser Val Thr Thr Gly Thr Ile Thr Asp Lys Leu Arg Glu Asp Trp 
    850                 855                 860                 


Gly Leu Val Glu Ile Met Lys Glu Leu Asn Trp Glu Lys Tyr Asp Lys 
865                 870                 875                 880 


Leu Gly Leu Thr Tyr Thr Ile Glu Gly Lys His Gly Glu Arg Leu Asn 
                885                 890                 895     


Lys Ile Lys Asp Trp Ser Lys Arg Asn Asp His Arg His His Ala Met 
            900                 905                 910         


Asp Ala Leu Thr Val Ala Leu Thr Lys Pro Ala Tyr Ile Gln Tyr Leu 
        915                 920                 925             


Asn Asn Leu Asn Ala Lys Glu Leu Asn Gly Lys Lys Ser Thr Glu Ile 
    930                 935                 940                 


Phe Ala Ile Glu Gln Lys Tyr Leu Lys Arg Glu Asn Gly Lys Leu Cys 
945                 950                 955                 960 


Phe Ile Pro Pro Val Glu Asn Ile Arg Thr Glu Ala Lys Lys His Leu 
                965                 970                 975     


Ser Lys Val Leu Ile Ser Tyr Lys Ala Lys Asn Lys Val Val Thr Ile 
            980                 985                 990         


Asn Lys Asn Arg Thr Asn Lys Lys  Ala Gly Phe Asn Glu  Gln Ile Ala 
        995                 1000                 1005             


Leu Thr  Pro Arg Gly Gln Leu  His Lys Glu Thr Val  Tyr Gly Lys 
    1010                 1015                 1020             


Ala Phe  His Tyr Ser Thr Lys  Phe Glu Lys Ile Gly  Ala Ser Phe 
    1025                 1030                 1035             


Asp Val  Gln Lys Ile Asn Ala  Val Ala Lys Lys Glu  Glu Arg Glu 
    1040                 1045                 1050             


Ala Leu  Leu Lys Arg Leu Ala  Glu Asn Gly Asp Asp  Pro Lys Lys 
    1055                 1060                 1065             


Ala Phe  Thr Gly Lys Asn Ser  Leu Ser Lys Met Pro  Ile Tyr Leu 
    1070                 1075                 1080             


Asp Leu  Lys Arg Asn Ile Lys  Leu Pro Glu Lys Val  Lys Thr Val 
    1085                 1090                 1095             


Val Leu  Glu Gln Asn Tyr Thr  Ile Arg Lys Asn Ile  Asp Pro Asp 
    1100                 1105                 1110             


Leu Lys  Leu Asp Lys Val Ile  Asp Val Gly Val Lys  Arg Ile Leu 
    1115                 1120                 1125             


Glu Asn  Arg Leu Lys Glu Phe  Gly Gly Asn Ala Lys  Leu Ala Leu 
    1130                 1135                 1140             


Ser Asn  Leu Asp Glu Asn Pro  Ile Trp Leu Asn Lys  Glu Lys Gly 
    1145                 1150                 1155             


Ile Thr  Ile Lys Arg Val Lys  Ile Ser Gly Val Ser  Asn Val Glu 
    1160                 1165                 1170             


Ser Leu  His Val Lys Lys Asp  His Phe Gly Glu Pro  Ile Leu Asp 
    1175                 1180                 1185             


Gln Val  Gly Asn Glu Ile Pro  Val Asp Phe Val Ser  Thr Gly Asn 
    1190                 1195                 1200             


Asn His  His Val Ala Ile Tyr  Glu Asp Glu Lys Gly  Asn Leu Gln 
    1205                 1210                 1215             


Glu Glu  Val Val Ser Phe Phe  Glu Ala Val Val Arg  Gln Asn Gln 
    1220                 1225                 1230             


Gly Leu  Pro Ile Ile Asn Lys  Asn His Ser Leu Gly  Trp Lys Phe 
    1235                 1240                 1245             


Leu Phe  Thr Leu Lys Gln Asn  Glu Tyr Phe Val Phe  Pro Ser Asp 
    1250                 1255                 1260             


Asp Phe  Asp Pro Thr Asp Val  Asp Leu Met Asp Glu  Glu Asn Tyr 
    1265                 1270                 1275             


His Leu  Ile Ser Pro Asn Leu  Phe Arg Val Gln Lys  Phe Thr Thr 
    1280                 1285                 1290             


Lys Asp  Tyr Phe Phe Arg His  His Leu Glu Thr Thr  Val Glu Asp 
    1295                 1300                 1305             


Lys Ser  Glu Leu Lys Gly Val  Ser Phe Lys Arg Leu  Gly Leu Pro 
    1310                 1315                 1320             


Gly Leu  Asn Cys Ile Lys Lys  Ile Arg Ile Asn His  Leu Gly Lys 
    1325                 1330                 1335             


Ile Ile  Gln Val Gly Glu Tyr  
    1340                 1345 


<210> 316
<211> 1352
<212> PRT
<213> Megasphaera sp.


<220>
<223> Megasphaera sp. UPII 135-E

<400> 316
Met Lys Lys Arg Asn Arg Glu Glu Tyr Tyr Val Gly Leu Asp Ile Gly 
1               5                   10                  15      


Thr Ser Ser Val Gly Trp Ala Val Ala Thr Pro Asp Tyr Arg Ile Pro 
            20                  25                  30          


Lys Phe Arg Gly His Lys Met Trp Gly Ser Arg Leu Phe Ala Glu Gly 
        35                  40                  45              


Lys Arg Ala Ala Glu Arg Arg Gln Phe Arg Thr Asn Arg Arg Arg Leu 
    50                  55                  60                  


Ala Arg Arg Arg Asp Arg Leu Gln Ile Leu Glu Glu Leu Phe Ala Glu 
65                  70                  75                  80  


Glu Met Ala Lys Val Asp Asn Thr Phe Phe Met Arg Leu Lys Glu Ser 
                85                  90                  95      


Lys Phe Phe Leu Glu Asp Lys Thr Val Lys Glu Lys His Ile Leu Phe 
            100                 105                 110         


Ser Thr Asp Lys Phe Asp Ala Asp Arg Phe Tyr Lys Asp Asn Pro Thr 
        115                 120                 125             


Ile Tyr His Val Arg Lys Arg Leu Met Glu Glu Glu Pro Gln Asp Ile 
    130                 135                 140                 


Arg Glu Leu Phe Leu Ala Val His His Ile Leu Lys Tyr Arg Gly His 
145                 150                 155                 160 


Phe Leu Phe Ala Gly Ser Leu Glu Gln Asn Gly Ala Ser Ile Glu Glu 
                165                 170                 175     


Leu Val Arg Thr Leu Leu Gly Lys Gln Gly Leu Ala Ile Leu Asp Asp 
            180                 185                 190         


Thr Ile Asp Ser Asn Glu Met Val Asn Ile Leu Lys Asn Thr Gly Glu 
        195                 200                 205             


Thr Lys Ser Asp Arg Lys Lys Asp Val Gln Glu Leu Trp Asn Pro Leu 
    210                 215                 220                 


Lys Asp Lys Val Lys Lys Ala Gln Ala Ala Glu Met Ala Gly Leu Val 
225                 230                 235                 240 


Leu Gly Leu Lys Ser Asp Ile Ser Lys Leu Phe Ala Asn Ser Asp Tyr 
                245                 250                 255     


Lys Asp Leu Asp Ser Ser Ile Lys Asn Ile Asn Phe Ser Ser Gly Asp 
            260                 265                 270         


Tyr Glu Glu Lys Arg Asp Asp Tyr Ala Asn Ser Ile Gly Asp Asp Ile 
        275                 280                 285             


Val Leu Leu Asp Thr Met Lys Ala Leu Tyr Asp Thr Leu Ile Leu Ser 
    290                 295                 300                 


Gln Ile Leu Gln Gly Lys Arg Ser Ile Ser Ala Ala Lys Val Glu Asp 
305                 310                 315                 320 


Tyr Asn Thr His Lys Glu Gln Leu Arg Ala Leu Lys Ala Ile Leu Lys 
                325                 330                 335     


Pro His Lys Arg Leu Tyr Asn Glu Met Phe Arg Glu Asn Asn Lys Lys 
            340                 345                 350         


Asp Leu Ser Asn Tyr Val Ala Tyr Ile Ser Ser Tyr Ser Glu Gly Lys 
        355                 360                 365             


Arg Val Asn Arg Glu Gly Phe Tyr Lys Tyr Val Gln Ala Val Leu Lys 
    370                 375                 380                 


Gln Val Asp Asp Ser Asp Ser Lys Gln Ala Ile Leu Glu Ala Ile Arg 
385                 390                 395                 400 


Leu Glu Thr Phe Leu Pro Leu Leu Arg Val Lys Asp Asn Ala Val Ile 
                405                 410                 415     


Pro His Gln Ile His Gln Ala Glu Leu Glu Ala Ile Leu Glu Thr Ala 
            420                 425                 430         


Arg Lys Lys Tyr Asn Phe Leu Asn Asp Val Ser Asp Gly Val Ser Val 
        435                 440                 445             


Lys Asp Lys Ile Ile Gln Leu Phe Thr Phe Arg Ile Pro Tyr Tyr Val 
    450                 455                 460                 


Gly Pro Leu Asn Pro His Ser Gly Glu Thr Val Ala Asp Arg Lys Gln 
465                 470                 475                 480 


Gly Thr Gly Trp Val Val Arg Lys Gln Arg Gly Lys Val Tyr Pro Trp 
                485                 490                 495     


Asn Phe Ala Asp Met Val Asp Val Lys Ala Ser Ala Glu Ala Phe Ile 
            500                 505                 510         


Thr Asn Leu Thr Asn Lys Cys Thr Tyr Leu Ile Gly Glu Asp Val Leu 
        515                 520                 525             


Pro Lys Arg Ser Leu Leu Tyr Ser Glu Phe Met Leu Leu Asn Glu Leu 
    530                 535                 540                 


Asn Met Ile Lys Tyr Asp Gly His Glu Leu Pro Val Ala Ile Lys Gln 
545                 550                 555                 560 


Leu Tyr Ile Glu Gln Val Phe Lys Gln Glu His Lys Lys Gln Thr Lys 
                565                 570                 575     


Gly Arg Val Leu Asp Phe Leu Lys Arg Asn Gly Leu Ile Thr Gly Ser 
            580                 585                 590         


Ala Thr Ala Val Ile Thr Gly Met Asp Asp Ala Ile Lys Gly Asp Leu 
        595                 600                 605             


Gln Ser Tyr Arg Asp Met Val Arg Ile Phe Gly Ala Gly Phe Asp His 
    610                 615                 620                 


Ser Met Ala Glu Arg Ile Ile Arg Trp Val Thr Leu Phe Gly Glu Ala 
625                 630                 635                 640 


Lys Asp Ile Leu Glu Asn Lys Ile Arg Glu Val Tyr Gly Asn Ser Ile 
                645                 650                 655     


Ser Asp Ser Gln Met Arg Ala Ile Lys Lys Leu Lys Tyr Ala Asp Trp 
            660                 665                 670         


Gly Arg Leu Ser Gln Ala Phe Leu Ile Ala Val Lys Gly Cys Asp Lys 
        675                 680                 685             


Ser Gly Val Glu Arg Asn Ile Ile Thr Cys Leu Arg Ala Ser Ser Gln 
    690                 695                 700                 


Asn Leu Met Glu Ile Leu Ser Asp Gln Gly Thr Tyr Ile Lys Gln Ile 
705                 710                 715                 720 


Lys Ala Trp Asn His Gln His Thr Thr Asn Met Met Asp Thr Leu Asp 
                725                 730                 735     


Tyr Gln Leu Val Asp Asp Leu Tyr Val Ala Pro Ser Val Lys Arg Ser 
            740                 745                 750         


Ile Trp Gln Ser Leu Cys Ile Val Glu Glu Leu Val Lys Ile Met Gly 
        755                 760                 765             


Gln Ala Pro Lys Lys Ile Phe Val Glu Val Thr Arg Thr Lys Gln Ala 
    770                 775                 780                 


Glu Lys Thr Lys Lys Asp Ser Arg Lys Lys Arg Leu Val Glu Leu Tyr 
785                 790                 795                 800 


Thr Ala Ile Gly Lys Glu Gly Ala Ala Trp Lys Lys Glu Ile Glu Ala 
                805                 810                 815     


His Gln Ala Gly Asp Phe Arg Arg Lys Lys Leu Tyr Leu Tyr Tyr Thr 
            820                 825                 830         


Gln Met Gly Arg Cys Met Tyr Ser Asn Glu Pro Ile Ala Met Asp Ala 
        835                 840                 845             


Leu Phe Thr Ser Ala Tyr Asp Ile Asp His Ile Tyr Pro Gln Ser Leu 
    850                 855                 860                 


Thr Lys Asp Gly Ser Trp Asp Asn Leu Val Leu Val Lys Ser Gln Leu 
865                 870                 875                 880 


Asn Lys Glu Lys Ser Asp Gln Tyr Pro Leu Arg Pro Ala Ile Arg Glu 
                885                 890                 895     


Lys Asn Lys Ala His Trp Gln Tyr Leu Cys Arg Ala Gly Phe Ile Ser 
            900                 905                 910         


Glu Lys Lys Tyr Glu Arg Leu Met Arg Thr Thr Glu Leu Thr Ala Glu 
        915                 920                 925             


Glu Leu Ser Gly Phe Ile Ala Arg Gln Leu Val Glu Thr Ser Gln Ala 
    930                 935                 940                 


Thr Lys Ala Val Thr Gly Leu Leu Glu Arg Ile Tyr Thr Asn Thr Glu 
945                 950                 955                 960 


Ile Cys Phe Val Lys Ala Glu Thr Val Ser Gln Phe Arg His Gln His 
                965                 970                 975     


Asn Phe Ile Lys Ile Arg Glu Leu Asn Asn Tyr His His Ala Lys Asp 
            980                 985                 990         


Ala Tyr Leu Asn Ile Val Val Gly  Asn Val Tyr His Glu  Lys Phe Thr 
        995                 1000                 1005             


Lys Asn  Pro Trp Glu Phe Ile  Ala Arg Ser Thr Glu  Arg Arg Pro 
    1010                 1015                 1020             


Tyr Asn  Leu Asn Arg Met Tyr  Asp Phe Asp Leu Leu  Lys Gln Gly 
    1025                 1030                 1035             


Arg Val  Ile Trp Gln Val Pro  Lys Ser Leu Glu Thr  Val Gln Ala 
    1040                 1045                 1050             


Met Met  Lys Ser Asn Asp Val  Arg Ile Thr Lys Lys  Leu Leu Val 
    1055                 1060                 1065             


Gln Lys  Gly Glu Leu Tyr Asp  Ala Thr Ile Thr Lys  Ala His Lys 
    1070                 1075                 1080             


Ala Lys  Glu Gly Thr Tyr Phe  Pro Leu Lys Gly Ala  Asp Ala Arg 
    1085                 1090                 1095             


Leu Arg  Asp Val His Arg Tyr  Gly Gly Tyr Glu Lys  Ile Lys Ile 
    1100                 1105                 1110             


Ala Tyr  Tyr Ser Val Phe Ser  Cys Arg Glu Lys Ala  Ser Asn Thr 
    1115                 1120                 1125             


Ile His  Thr Leu Ile Ile Pro  Ile Pro Val Tyr Lys  Ala Gly Leu 
    1130                 1135                 1140             


Leu Gln  Thr Glu Ala Asp Leu  Thr Ala Tyr Ala Trp  Gln Thr Lys 
    1145                 1150                 1155             


Gln Lys  Thr Lys Pro Ile Lys  Asp Ile Tyr Ser Ala  Ile Thr Pro 
    1160                 1165                 1170             


Ile Tyr  Lys Lys Leu Cys Ile  Asn Thr Val Val Lys  Ile Asp Gly 
    1175                 1180                 1185             


Phe Lys  Tyr Phe Leu Gly Gly  Lys Thr Gly Asp Tyr  Met Trp Leu 
    1190                 1195                 1200             


Asp Pro  Ala Ile Pro Val Val  Leu Asp Glu Gln Ala  Ala Ala Tyr 
    1205                 1210                 1215             


Leu Lys  Ala Ile Ser Lys Val  Gly Arg Ala Asp Asp  Val Glu Asn 
    1220                 1225                 1230             


Thr Ala  Gln Ala Ile Asp Leu  Ile Thr Ala Glu Ala  Asn Glu Ala 
    1235                 1240                 1245             


Phe Tyr  Asp Val Leu Leu Lys  Lys Met Glu Ala Lys  Ile Phe Ala 
    1250                 1255                 1260             


Lys Ala  Tyr Gln Thr Ile Val  Glu Lys Leu Ala Ser  Glu Thr Ala 
    1265                 1270                 1275             


Arg Glu  Arg Phe Arg Glu Leu  Ser Ile Gly Ala Gln  Cys Ser Cys 
    1280                 1285                 1290             


Leu Leu  Glu Ile Leu Asn Leu  Leu Ala Asn Asn Lys  Thr Thr Phe 
    1295                 1300                 1305             


Thr Phe  Phe Lys Asp Lys Met  Gly Val Thr Met Ser  Arg Arg Lys 
    1310                 1315                 1320             


Gln Pro  Met Asp Leu Thr Lys  Leu Glu Glu Cys Ile  Val Tyr Glu 
    1325                 1330                 1335             


Thr Ser  Ile Thr Gly Leu Tyr  Glu Lys Ala Val Ser  Leu Leu 
    1340                 1345                 1350         


<210> 317
<211> 1080
<212> PRT
<213> Methylocystis sp.


<220>
<223> Methylocystis sp. ATCC 49242

<400> 317
Met Arg Val Leu Gly Leu Asp Gly Gly Ile Ala Ser Ile Gly Trp Ala 
1               5                   10                  15      


Leu Ile Glu Ile Phe Glu Asp His Glu Pro Ser Asp Gly Arg Ile Ile 
            20                  25                  30          


Asp Thr Gly Ala Trp Met Phe Asp Ala Pro Glu Glu Lys Ser Gln Thr 
        35                  40                  45              


Gly Thr Lys Leu Lys Ser Glu Leu Arg Arg Ile Phe Arg Gly Gln Arg 
    50                  55                  60                  


Arg Val Ile Arg Arg Arg Arg Gln Arg Met Asn Glu Val Arg Arg Ile 
65                  70                  75                  80  


Leu His Arg His Gly Leu Leu Ser Ser Asp Asn Arg Asp Ala Leu Lys 
                85                  90                  95      


Gln Pro Gly Leu Asp Pro Trp Lys Ile Arg Ala Glu Gly Ile Asp Arg 
            100                 105                 110         


Leu Leu Ser Pro Ile Glu Phe Ala Val Ala Leu Gly His Ile Ala Arg 
        115                 120                 125             


His Arg Gly Phe Lys Ser Asn Ser Lys Gly Ala Lys Thr Ser Asp Leu 
    130                 135                 140                 


Asp Ala Glu Ser Ser Arg Met Lys Lys Ala Val Gly Glu Thr Arg Glu 
145                 150                 155                 160 


Lys Leu Ala Arg Phe Gly Ser Pro Ala Lys Leu Leu Val Glu Asp Glu 
                165                 170                 175     


Gly Phe Val Leu Arg Gln Thr Lys Leu Lys Ser Gly Ala Leu Glu Thr 
            180                 185                 190         


Val Arg Arg Phe Arg Asn Arg Asp Gly Asp Tyr Ser Arg Ser Leu Leu 
        195                 200                 205             


Arg Asp Asp Leu Ala Ala Glu Val Arg Ala Leu Phe Arg Ala Gln Ala 
    210                 215                 220                 


Arg Leu Gln Ser Thr Phe Ala Lys Val Glu Leu Glu Ala Glu Phe Thr 
225                 230                 235                 240 


Gln Ala Ala Phe Phe Gln Arg Pro Leu Gln Asp Ser Glu Arg Leu Val 
                245                 250                 255     


Gly Pro Cys Pro Phe Glu Pro Ala Glu Lys Arg Ser Pro Lys Arg Gly 
            260                 265                 270         


Tyr Ser Phe Glu Leu Phe Arg Phe Leu Ser Arg Leu Asn His Leu Thr 
        275                 280                 285             


Leu Arg Glu Gly Ser Glu Glu Arg Thr Leu Thr Val Glu Glu Leu Arg 
    290                 295                 300                 


Thr Ala Ala Ala Asp Phe Gly Gly Val Ala Lys Phe Thr Phe Ser Thr 
305                 310                 315                 320 


Leu Arg Lys Arg Leu Ala Leu Pro Asp Ile Ala Ile Phe Val Gly Ile 
                325                 330                 335     


Lys Ala Asp Asp Glu Lys Lys Leu Asp Val Val Ala Arg Ser Gly Glu 
            340                 345                 350         


Ala Ala Thr Gly Thr Ala Arg Leu Arg Arg Val Val Ile Asp Ala Leu 
        355                 360                 365             


Gly Glu Leu Ala Trp Gly Ala Leu Ile Ser Ala Pro Glu Arg Leu Asp 
    370                 375                 380                 


Lys Ile Thr Glu Ile Ile Thr Phe Arg Ser Asp Leu Asp Arg Ile Arg 
385                 390                 395                 400 


Ala Gly Leu Ile Glu Ala Gly Phe Asp Thr Pro Leu Ile Glu Ala Ile 
                405                 410                 415     


Val Arg Ala Ala Ala Asp Gly Lys Leu Asp Ala Phe Thr Gly Val Gly 
            420                 425                 430         


His Ile Ser Ala Lys Ala Ala Arg Asn Ile Ile Pro Gly Leu Met Arg 
        435                 440                 445             


Gly Met Thr Tyr Asp Lys Ala Cys Ala Ala Ala Gly Tyr Asp His Thr 
    450                 455                 460                 


Ala Ser Arg Glu Arg Asp Ala Phe Asp Val Gly Met His Gly Lys Glu 
465                 470                 475                 480 


Ala Leu Lys Lys Ile Leu Gln Glu Glu Arg Ile Ser Arg Glu Leu Val 
                485                 490                 495     


Gly Ser Pro Ser Ala Arg Lys Ala Leu Ile Glu Ala Val Lys Gln Val 
            500                 505                 510         


Lys Ala Ile Ile Glu Lys Tyr Gly Val Pro Asp Arg Ile His Val Glu 
        515                 520                 525             


Leu Ala Arg Asp Val Gly Lys Ser Ile Glu Glu Arg Arg Asp Ile His 
    530                 535                 540                 


Phe Gly Ile Glu Lys Arg Ser Arg Gln Lys Asp Lys Leu Arg Glu Leu 
545                 550                 555                 560 


Phe Gly Lys Glu Val Gly His Leu Pro Gln Asp Gly Glu Arg Gly Lys 
                565                 570                 575     


Glu Glu Leu Leu Arg Phe Glu Leu Trp Asn Glu Gln Met Gly Arg Cys 
            580                 585                 590         


Leu Tyr Thr Asp Glu Tyr Ile Asn Pro Lys Gln Leu Val Ala Ser Asp 
        595                 600                 605             


Asn Ser Val Gln Val Asp His Ile Leu Pro Trp Ser Arg Phe Gly Asp 
    610                 615                 620                 


Asp Ser Tyr Leu Asn Lys Thr Leu Cys Thr Ala Lys Ala Asn Gln Asp 
625                 630                 635                 640 


Lys Lys Gly Arg Thr Pro Tyr Glu Trp Phe Arg Ala Asp Lys Pro Glu 
                645                 650                 655     


Ala Glu Trp Asp Ala Phe Val Ala Arg Val Glu Ser Ile Gln Phe Met 
            660                 665                 670         


Lys Gly Leu Lys Lys Arg Asn Tyr Lys Leu Lys Asn Ala Glu Glu Ala 
        675                 680                 685             


Ala Glu Lys Phe Arg Ser Arg Asn Leu Asn Asp Thr Arg Trp Thr Cys 
    690                 695                 700                 


Arg Leu Leu Ala Glu Ala Leu Lys Gln Leu Tyr Pro Lys Gly Glu Lys 
705                 710                 715                 720 


Asp Lys Asp Gly Lys Glu Arg Arg Arg Val Phe Thr Arg Pro Gly Ala 
                725                 730                 735     


Leu Thr Asn Arg Leu Arg Arg Ala Trp Ser Leu Gln Arg Arg Lys Lys 
            740                 745                 750         


Ser Glu Lys Gly Glu Arg Ile Ala Asp Asp Arg His His Ala Leu Asp 
        755                 760                 765             


Ala Ile Ile Val Ala Ala Thr Thr Glu Ser Leu Leu Ile Arg Ala Thr 
    770                 775                 780                 


Arg Glu Val Gln Asp Ile Glu Arg Lys Gly Leu His Tyr Asp Leu Thr 
785                 790                 795                 800 


Lys Asn Ile Thr Gln Pro Trp Pro Gly Phe Ala Asp Glu Ala Leu Asp 
                805                 810                 815     


Ala Val Glu Lys Val Phe Val Ala Arg Ala Glu Arg Arg Arg Ala Arg 
            820                 825                 830         


Gly Lys Ala His Asp Ala Thr Ile Arg His Ile Ala Val Arg Asp Asp 
        835                 840                 845             


Glu Ala Lys Val Tyr Glu Arg Lys Lys Val Gly Asp Ile Lys Leu Gly 
    850                 855                 860                 


Asp Leu Ile Arg Val Lys Asp Ala Glu Arg Asn Ala Pro Leu Ile Glu 
865                 870                 875                 880 


Asn Leu Arg Lys Trp Ile Glu Ala Gly Ser Pro Arg Asp Asn Pro Pro 
                885                 890                 895     


Leu Ser Pro Lys Gly Asp Pro Val Ser Lys Val Arg Leu Val Thr Lys 
            900                 905                 910         


Asn Lys Val Asn Ile Thr Leu Asp Thr Gly Asn Pro Glu Arg Leu Ala 
        915                 920                 925             


Thr Val Asp Arg Gly Glu Met Ala Arg Val Asp Val Phe Arg Lys Ala 
    930                 935                 940                 


Asn Arg Lys Gly Lys Tyr Glu Tyr Tyr Leu Val Pro Ile Tyr Pro His 
945                 950                 955                 960 


Glu Ile Ala Thr Met Glu Thr Pro Pro Met Arg Ala Val Gln Gly Gly 
                965                 970                 975     


Gly Asp Asp Asp Lys Trp Pro Glu Ile Asp Ser Thr Phe Glu Phe Leu 
            980                 985                 990         


Trp Ser Ile Asn Gln Leu Ser Leu  Leu Glu Leu Thr Lys  Pro Asp Gly 
        995                 1000                 1005             


Glu Val  Ile Arg Ser Tyr Phe  Arg Ser Leu Asp Arg  Asn Thr Gly 
    1010                 1015                 1020             


Ala Leu  Thr Val Ser Gly Ile  Ala Asn Ser Thr Ala  Thr Arg Lys 
    1025                 1030                 1035             


Gly Ile  Gly Thr Arg Thr Leu  Ile Asp Phe Lys Lys  Leu His Val 
    1040                 1045                 1050             


Asp Arg  Leu Gly Gln Ile Phe  Glu Val Glu Arg Glu  Leu Arg Thr 
    1055                 1060                 1065             


Trp Arg  Gly Glu Thr Trp Arg  Gly Lys Asp Cys Ile  
    1070                 1075                 1080 


<210> 318
<211> 1082
<212> PRT
<213> Methylosinus trichosporium


<220>
<223> Methylosinus trichosporium OB3b

<400> 318
Met Arg Val Leu Gly Leu Asp Ala Gly Ile Ala Ser Leu Gly Trp Ala 
1               5                   10                  15      


Leu Ile Glu Ile Glu Glu Ser Asn Arg Gly Glu Leu Ser Gln Gly Thr 
            20                  25                  30          


Ile Ile Gly Ala Gly Thr Trp Met Phe Asp Ala Pro Glu Glu Lys Thr 
        35                  40                  45              


Gln Ala Gly Ala Lys Leu Lys Ser Glu Gln Arg Arg Thr Phe Arg Gly 
    50                  55                  60                  


Gln Arg Arg Val Val Arg Arg Arg Arg Gln Arg Met Asn Glu Val Arg 
65                  70                  75                  80  


Arg Ile Leu His Ser His Gly Leu Leu Pro Ser Ser Asp Arg Asp Ala 
                85                  90                  95      


Leu Lys Gln Pro Gly Leu Asp Pro Trp Arg Ile Arg Ala Glu Ala Leu 
            100                 105                 110         


Asp Arg Leu Leu Gly Pro Val Glu Leu Ala Val Ala Leu Gly His Ile 
        115                 120                 125             


Ala Arg His Arg Gly Phe Lys Ser Asn Ser Lys Gly Ala Lys Thr Asn 
    130                 135                 140                 


Asp Pro Ala Asp Asp Thr Ser Lys Met Lys Arg Ala Val Asn Glu Thr 
145                 150                 155                 160 


Arg Glu Lys Leu Ala Arg Phe Gly Ser Ala Ala Lys Met Leu Val Glu 
                165                 170                 175     


Asp Glu Ser Phe Val Leu Arg Gln Thr Pro Thr Lys Asn Gly Ala Ser 
            180                 185                 190         


Glu Ile Val Arg Arg Phe Arg Asn Arg Glu Gly Asp Tyr Ser Arg Ser 
        195                 200                 205             


Leu Leu Arg Asp Asp Leu Ala Ala Glu Met Arg Ala Leu Phe Thr Ala 
    210                 215                 220                 


Gln Ala Arg Phe Gln Ser Ala Ile Ala Thr Ala Asp Leu Gln Thr Ala 
225                 230                 235                 240 


Phe Thr Lys Ala Ala Phe Phe Gln Arg Pro Leu Gln Asp Ser Glu Lys 
                245                 250                 255     


Leu Val Gly Pro Cys Pro Phe Glu Val Asp Glu Lys Arg Ala Pro Lys 
            260                 265                 270         


Arg Gly Tyr Ser Phe Glu Leu Phe Arg Phe Leu Ser Arg Leu Asn His 
        275                 280                 285             


Val Thr Leu Arg Asp Gly Lys Gln Glu Arg Thr Leu Thr Arg Asp Glu 
    290                 295                 300                 


Leu Ala Leu Ala Ala Ala Asp Phe Gly Ala Ala Ala Lys Val Ser Phe 
305                 310                 315                 320 


Thr Ala Leu Arg Lys Lys Leu Lys Leu Pro Glu Thr Thr Val Phe Val 
                325                 330                 335     


Gly Val Lys Ala Asp Glu Glu Ser Lys Leu Asp Val Val Ala Arg Ser 
            340                 345                 350         


Gly Lys Ala Ala Glu Gly Thr Ala Arg Leu Arg Ser Val Ile Val Asp 
        355                 360                 365             


Ala Leu Gly Glu Leu Ala Trp Gly Ala Leu Leu Cys Ser Pro Glu Lys 
    370                 375                 380                 


Leu Asp Lys Ile Ala Glu Val Ile Ser Phe Arg Ser Asp Ile Gly Arg 
385                 390                 395                 400 


Ile Ser Glu Gly Leu Ala Gln Ala Gly Cys Asn Ala Pro Leu Val Asp 
                405                 410                 415     


Ala Leu Thr Ala Ala Ala Ser Asp Gly Arg Phe Asp Pro Phe Thr Gly 
            420                 425                 430         


Ala Gly His Ile Ser Ser Lys Ala Ala Arg Asn Ile Leu Ser Gly Leu 
        435                 440                 445             


Arg Gln Gly Met Thr Tyr Asp Lys Ala Cys Cys Ala Ala Asp Tyr Asp 
    450                 455                 460                 


His Thr Ala Ser Arg Glu Arg Gly Ala Phe Asp Val Gly Gly His Gly 
465                 470                 475                 480 


Arg Glu Ala Leu Lys Arg Ile Leu Gln Glu Glu Arg Ile Ser Arg Glu 
                485                 490                 495     


Leu Val Gly Ser Pro Thr Ala Arg Lys Ala Leu Ile Glu Ser Ile Lys 
            500                 505                 510         


Gln Val Lys Ala Ile Val Glu Arg Tyr Gly Val Pro Asp Arg Ile His 
        515                 520                 525             


Val Glu Leu Ala Arg Asp Val Gly Lys Ser Ile Glu Glu Arg Glu Glu 
    530                 535                 540                 


Ile Thr Arg Gly Ile Glu Lys Arg Asn Arg Gln Lys Asp Lys Leu Arg 
545                 550                 555                 560 


Gly Leu Phe Glu Lys Glu Val Gly Arg Pro Pro Gln Asp Gly Ala Arg 
                565                 570                 575     


Gly Lys Glu Glu Leu Leu Arg Phe Glu Leu Trp Ser Glu Gln Met Gly 
            580                 585                 590         


Arg Cys Leu Tyr Thr Asp Asp Tyr Ile Ser Pro Ser Gln Leu Val Ala 
        595                 600                 605             


Thr Asp Asp Ala Val Gln Val Asp His Ile Leu Pro Trp Ser Arg Phe 
    610                 615                 620                 


Ala Asp Asp Ser Tyr Ala Asn Lys Thr Leu Cys Met Ala Lys Ala Asn 
625                 630                 635                 640 


Gln Asp Lys Lys Gly Arg Thr Pro Tyr Glu Trp Phe Lys Ala Glu Lys 
                645                 650                 655     


Thr Asp Thr Glu Trp Asp Ala Phe Ile Val Arg Val Glu Ala Leu Ala 
            660                 665                 670         


Asp Met Lys Gly Phe Lys Lys Arg Asn Tyr Lys Leu Arg Asn Ala Glu 
        675                 680                 685             


Glu Ala Ala Ala Lys Phe Arg Asn Arg Asn Leu Asn Asp Thr Arg Trp 
    690                 695                 700                 


Ala Cys Arg Leu Leu Ala Glu Ala Leu Lys Gln Leu Tyr Pro Lys Gly 
705                 710                 715                 720 


Glu Lys Asp Lys Asp Gly Lys Glu Arg Arg Arg Val Phe Ser Arg Pro 
                725                 730                 735     


Gly Ala Leu Thr Asp Arg Leu Arg Arg Ala Trp Gly Leu Gln Trp Met 
            740                 745                 750         


Lys Lys Ser Thr Lys Gly Asp Arg Ile Pro Asp Asp Arg His His Ala 
        755                 760                 765             


Leu Asp Ala Ile Val Ile Ala Ala Thr Thr Glu Ser Leu Leu Gln Arg 
    770                 775                 780                 


Ala Thr Arg Glu Val Gln Glu Ile Glu Asp Lys Gly Leu His Tyr Asp 
785                 790                 795                 800 


Leu Val Lys Asn Val Thr Pro Pro Trp Pro Gly Phe Arg Glu Gln Ala 
                805                 810                 815     


Val Glu Ala Val Glu Lys Val Phe Val Ala Arg Ala Glu Arg Arg Arg 
            820                 825                 830         


Ala Arg Gly Lys Ala His Asp Ala Thr Ile Arg His Ile Ala Val Arg 
        835                 840                 845             


Glu Gly Glu Gln Arg Val Tyr Glu Arg Arg Lys Val Ala Glu Leu Lys 
    850                 855                 860                 


Leu Ala Asp Leu Asp Arg Val Lys Asp Ala Glu Arg Asn Ala Arg Leu 
865                 870                 875                 880 


Ile Glu Lys Leu Arg Asn Trp Ile Glu Ala Gly Ser Pro Lys Asp Asp 
                885                 890                 895     


Pro Pro Leu Ser Pro Lys Gly Asp Pro Ile Phe Lys Val Arg Leu Val 
            900                 905                 910         


Thr Lys Ser Lys Val Asn Ile Ala Leu Asp Thr Gly Asn Pro Lys Arg 
        915                 920                 925             


Pro Gly Thr Val Asp Arg Gly Glu Met Ala Arg Val Asp Val Phe Arg 
    930                 935                 940                 


Lys Ala Ser Lys Lys Gly Lys Tyr Glu Tyr Tyr Leu Val Pro Ile Tyr 
945                 950                 955                 960 


Pro His Asp Ile Ala Thr Met Lys Thr Pro Pro Ile Arg Ala Val Gln 
                965                 970                 975     


Ala Tyr Lys Pro Glu Asp Glu Trp Pro Glu Met Asp Ser Ser Tyr Glu 
            980                 985                 990         


Phe Cys Trp Ser Leu Val Pro Met  Thr Tyr Leu Gln Val  Ile Ser Ser 
        995                 1000                 1005             


Lys Gly  Glu Ile Phe Glu Gly  Tyr Tyr Arg Gly Met  Asn Arg Ser 
    1010                 1015                 1020             


Val Gly  Ala Ile Gln Leu Ser  Ala His Ser Asn Ser  Ser Asp Val 
    1025                 1030                 1035             


Val Gln  Gly Ile Gly Ala Arg  Thr Leu Thr Glu Phe  Lys Lys Phe 
    1040                 1045                 1050             


Asn Val  Asp Arg Phe Gly Arg  Lys His Glu Val Glu  Arg Glu Leu 
    1055                 1060                 1065             


Arg Thr  Trp Arg Gly Glu Thr  Trp Arg Gly Lys Ala  Tyr Ile 
    1070                 1075                 1080         


<210> 319
<211> 1123
<212> PRT
<213> Mobiluncus curtisii


<220>
<223> Mobiluncus curtisii subsp. holmesii ATCC 35242

<400> 319
Met Phe Val Tyr Leu Asn Ser Pro Arg Gly Phe Gly Pro Ala Thr Phe 
1               5                   10                  15      


Leu Thr Asp Leu Pro His Phe Cys Ile Ile Phe Gly Asn Asn Asp Phe 
            20                  25                  30          


Met Asp Asn Arg Lys Tyr His Val Gly Ile Asp Val Gly Thr Asn Ser 
        35                  40                  45              


Val Gly Phe Ala Ala Val Glu Val Gly Asp Ser Gly Ser Pro Ile Arg 
    50                  55                  60                  


Phe Leu Asn Thr Met Val Val Ile His Asp Ser Gly Val Asp Pro Glu 
65                  70                  75                  80  


Gln Lys Lys Tyr Ala Ile Thr Arg Leu Ala Ser Ala Gly Thr Ala Arg 
                85                  90                  95      


Arg Thr Arg Arg Leu Tyr Arg Thr Arg Arg Gln Arg Leu Arg Glu Leu 
            100                 105                 110         


Asp Asp Phe Ile Ser Asn Glu Leu Gly Tyr Pro Leu Val Asn Leu Glu 
        115                 120                 125             


Asn Phe Ala Asp Pro Tyr Glu Pro Trp Lys Val Arg Ala Asp Leu Ala 
    130                 135                 140                 


Thr Ile Lys Leu Pro Ala Asp Glu Leu Pro Glu Ala Met Ser Ile Ala 
145                 150                 155                 160 


Leu Arg His Met Ala Arg His Arg Gly Trp Arg Ser Pro Tyr Gln Arg 
                165                 170                 175     


Val Glu Ala Leu His Leu His Ala Glu Ile Ser Glu Glu Phe Ser Ala 
            180                 185                 190         


Leu Lys Lys Arg Val Met Glu Lys Thr Gly Asp Val Phe Ser Asp Asp 
        195                 200                 205             


Ala Thr Pro Ala Glu Val Leu Val Asp Leu Met Gly Arg Gln Lys Ile 
    210                 215                 220                 


Arg Gly Ala Asp Gly Met Leu Ser Gly Lys Leu Arg Gln Ser Asp Asn 
225                 230                 235                 240 


Ala Asn Glu Leu Arg Lys Ile Ala Ser Val Gln Gly Ile Asp Asp Glu 
                245                 250                 255     


Thr Leu Asn Arg Ile Ile Asp Arg Val Phe Phe Ser Arg Ser Pro Lys 
            260                 265                 270         


Gly Lys Ala Ser Glu Arg Val Gly Met Asp Ala Leu Pro Gly Gln Gly 
        275                 280                 285             


Ser Lys Pro Arg Ala Leu Lys Ala Met Pro Ser Phe Gln Lys Phe Arg 
    290                 295                 300                 


Ile Val Ser Val Ile Cys Asn Leu Arg Ile Lys Asp Ser Gly Asp Asp 
305                 310                 315                 320 


Asn Arg Pro Leu Ser Met Glu Glu Lys Glu Gln Leu Ile Gly Tyr Leu 
                325                 330                 335     


Met Ser Ser Thr Thr Asp Asp His Val Thr Trp Thr Asp Val Ala Glu 
            340                 345                 350         


Leu Leu His Val Lys Arg Ser Asn Leu Gln Gly Thr Ala Lys Glu Gly 
        355                 360                 365             


Pro Asp Gly Glu Arg Pro Tyr Thr Arg Pro Pro Val Asn Ser Ala Trp 
    370                 375                 380                 


Ser Lys Ile Lys Asp Ser Lys Ile Lys Ser Leu Val Ala Leu Trp Lys 
385                 390                 395                 400 


Thr Gly Asp Val Asp Val Gln Ser Ala Ile Val Glu Ala Leu Ser Asn 
                405                 410                 415     


Ala Ser Val Leu Glu Asp Ala Arg Pro Gly Ala Asp Ile Val Val Ala 
            420                 425                 430         


Tyr Leu Glu Ser Leu Asp Asp Lys Glu Leu Glu Ser Leu Asp Lys Val 
        435                 440                 445             


Gly Leu Pro Ala Gly Arg Ala Ser Tyr Ser Glu Asp Ser Leu Glu Arg 
    450                 455                 460                 


Leu Thr Glu Arg Met Leu Gln Asp Asp Cys Asp Leu Phe Glu Ala Arg 
465                 470                 475                 480 


Lys Arg Glu Phe Gly Val Ser Asp Asp Trp Lys Pro Pro Ala Asp Pro 
                485                 490                 495     


Ile Tyr Ala Pro Val Gly Asn Pro Gly Val Asp Arg Val Leu Lys Ile 
            500                 505                 510         


Val Asn Arg Leu Leu Met Ala Ala Glu Arg Glu Trp Gly Ala Pro Thr 
        515                 520                 525             


Gln Ile Asn Ile Glu His Val Arg Ser Gly Phe Ser Ser Glu Leu Met 
    530                 535                 540                 


Gln Arg Glu Phe Glu Arg Glu Asn Glu Arg Arg Arg Ala Gln Asn Glu 
545                 550                 555                 560 


Glu Ala Val Lys Ala Ile Leu Thr Glu Lys Gly Gly Asn Ser His Val 
                565                 570                 575     


Ser Lys Tyr Asp Ile Ile Arg Tyr Tyr Ala Val Lys Arg Gln Asn Cys 
            580                 585                 590         


Gln Cys Leu Tyr Cys Gly Thr Pro Ile Thr Phe Ser Asp Cys Glu Leu 
        595                 600                 605             


Asp His Ile Val Pro Arg Lys Gly Val Gly Ser Thr Asn Ser Arg Val 
    610                 615                 620                 


Asn Leu Ala Ala Ala Cys Arg Ser Cys Asn Arg Asp Lys Ser Asn Leu 
625                 630                 635                 640 


Pro Phe Ala Val Trp Ala Gly Lys Thr Ser Asn Phe Asp Val Ser Ile 
                645                 650                 655     


Asp Gly Ala Val Ser Arg Val Lys Gln Trp Gln Arg Ser Gln Asn Glu 
            660                 665                 670         


Gly Ala Arg Glu Phe Arg Ala Phe Gln Asn Glu Val Ile Ser Arg Leu 
        675                 680                 685             


Leu Lys Thr Thr Glu Asp Pro Glu Ile Asp Ser Arg Ser Leu Glu Ser 
    690                 695                 700                 


Val Ala Trp Met Ala Arg Glu Leu His His Arg Val Glu Tyr Tyr Phe 
705                 710                 715                 720 


Gln Ser Lys Gly Ala Gln Thr Gln Val Ser Val Tyr Arg Gly Ala Val 
                725                 730                 735     


Thr Ala Gln Ala Arg Lys Ser Ser Gly Leu Glu Asp Lys Val Lys Met 
            740                 745                 750         


Ile Gly Gly Gly Gly Lys Thr Arg Leu Asp Arg Arg His His Ala Met 
        755                 760                 765             


Asp Ala Ala Thr Ile Ala Leu Met Thr Pro Gly Ile Ser Thr Thr Leu 
    770                 775                 780                 


Ser Glu Lys Asn Asn Leu Arg Asp Ala Gln Lys Phe Thr Gly Gln Ser 
785                 790                 795                 800 


Glu Thr Trp Lys Asp Tyr Cys Gly Arg Thr Glu Thr Ala Arg Glu His 
                805                 810                 815     


Phe Ala Val Trp Lys Ser Asn Met Glu Arg Leu Thr Asp Leu Phe Asn 
            820                 825                 830         


Asp Lys Leu Glu Asn Asp Ala Ile Pro Val Val Gln Pro Leu Arg Leu 
        835                 840                 845             


Arg Leu Ser Asp Ser Lys Ala His Asp Asp Gly Ile Gly Lys Leu Asp 
    850                 855                 860                 


Ser Lys Lys Leu Gly Ser Val Trp Ser Leu Ala Asp Ile Asp Arg Ala 
865                 870                 875                 880 


Ala Thr Pro Gln Ile Trp Thr Ala Leu Thr Arg Cys Asp Asp Phe Asp 
                885                 890                 895     


Pro Thr Lys Gly Leu Pro Glu Asn Ala Asn Arg Val Ile Arg Ala Gln 
            900                 905                 910         


Gly Val Lys Tyr Glu Ser Glu Asp Asn Ile Pro Val Phe Pro Ser Asn 
        915                 920                 925             


Val Ala Ala Ile Ala Val Arg Asp Gly Tyr Ala Glu Ile Gly Ser Thr 
    930                 935                 940                 


Ile His His Ala Arg Ile Tyr Arg Ile Asp Asp Gly Lys Lys Ile Phe 
945                 950                 955                 960 


Tyr Ser Met Ile Arg Val Phe Ala Val Asp Leu Leu Lys His Gln Ala 
                965                 970                 975     


Glu Asp Leu Phe Thr Val Lys Leu Pro Pro Ser Ala Ile Ser Ile Arg 
            980                 985                 990         


Thr Cys Glu Asp Ser Leu Arg Arg  Ala Leu Ser Asn Gly  Thr Ala Glu 
        995                 1000                 1005             


Tyr Leu  Gly Trp Leu Val Pro  Gly Asp Glu Ile Ile  Val Asp Thr 
    1010                 1015                 1020             


Ser Asp  Lys Ala Phe His Thr  Gly Gln Ile Gly Asp  Leu Leu Arg 
    1025                 1030                 1035             


Asn Phe  Pro Val Asn Ser Phe  Arg Leu Thr Gly Phe  Pro Ser Asn 
    1040                 1045                 1050             


Ser Arg  Leu Arg Leu Lys Pro  Val Leu Leu Ala Gly  Glu Gly Leu 
    1055                 1060                 1065             


Arg Asp  Asp Ala Glu Asp Ser  Ile Lys Lys Ile Leu  Ser Gly Gln 
    1070                 1075                 1080             


Gly Trp  Arg Pro Ala Ile Asn  Val Leu Phe Ser Lys  Gly Lys Pro 
    1085                 1090                 1095             


Arg Ile  Val Arg Arg Asn Ser  Leu Gly Ile Glu Arg  Pro Ser Ser 
    1100                 1105                 1110             


Asn Asn  Gly Leu Pro Phe Ser  Trp Glu Ala 
    1115                 1120             


<210> 320
<211> 1091
<212> PRT
<213> Mobiluncus mulieris


<220>
<223> Mobiluncus mulieris 28-1

<400> 320
Met Asp Ser Arg Lys Tyr Arg Val Gly Ile Asp Val Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Phe Ala Ala Val Glu Glu Asp Asp Ser Gly Ser Pro Thr Arg 
            20                  25                  30          


Phe Leu Asn Thr Met Val Val Ile His Asp Ser Gly Val Asp Pro Glu 
        35                  40                  45              


Gln Lys Lys Tyr Ala Ile Thr Arg Leu Ala Ser Ala Gly Thr Ala Arg 
    50                  55                  60                  


Arg Thr Arg Arg Leu Tyr Arg Thr Arg Arg Gln Arg Leu Arg Glu Leu 
65                  70                  75                  80  


Asp Asp Phe Ile Ser Asn Glu Leu Gly Tyr Pro Leu Val Asn Leu Glu 
                85                  90                  95      


Asn Phe Ala Asp Pro Tyr Glu Pro Trp Lys Val Arg Ala Asp Leu Ala 
            100                 105                 110         


Thr Thr Lys Leu Pro Asn Asp Glu Leu Pro Glu Ala Met Ser Ile Ala 
        115                 120                 125             


Leu Arg His Met Ala Arg His Arg Gly Trp Arg Ser Pro Tyr Gln Arg 
    130                 135                 140                 


Val Glu Ala Leu His Leu His Ala Glu Ile Ser Lys Glu Phe Ala Ala 
145                 150                 155                 160 


Leu Lys Glu Arg Val Val Glu Lys Thr Gly Asp Val Phe Ser Asp Asp 
                165                 170                 175     


Ala Thr Pro Ala Glu Val Leu Val Asp Leu Met Gly Arg Gln Lys Val 
            180                 185                 190         


Arg Gly Ala Asp Gly Val Leu Ser Gly Lys Leu Arg Gln Ser Asp Asn 
        195                 200                 205             


Ala Asn Glu Leu Arg Lys Ile Ala Ser Val Gln Gly Ile Asp Asp Glu 
    210                 215                 220                 


Thr Leu Asn Arg Ile Ile Asp Arg Val Phe Ser Ser Lys Ser Pro Lys 
225                 230                 235                 240 


Gly Lys Ala Ser Glu Arg Val Gly Met Asp Ala Leu Pro Gly Gln Gly 
                245                 250                 255     


Ser Lys Pro Arg Ala Leu Lys Ala Met Pro Ser Phe Gln Lys Phe Arg 
            260                 265                 270         


Val Val Ser Val Ile Cys Asn Leu Arg Ile Lys Asp Ser Gly Gly Asp 
        275                 280                 285             


Ala Arg Pro Leu Ser Met Glu Glu Lys Glu Lys Leu Ile Asp Tyr Leu 
    290                 295                 300                 


Met Ser Ser Thr Thr Asp Asp His Val Thr Trp Thr Asp Val Ala Asp 
305                 310                 315                 320 


Leu Leu His Val Lys Arg Ser Gln Leu Gln Gly Thr Ala Lys Glu Gly 
                325                 330                 335     


Phe Asp Gly Glu Arg Pro Tyr Thr Arg Pro Pro Val Asn Ser Thr Trp 
            340                 345                 350         


Ser Lys Ile Lys Asp Ser Lys Ile Lys Ser Leu Val Ala Leu Trp Lys 
        355                 360                 365             


Thr Gly Asp Val Asp Val Gln Ser Ala Ile Val Glu Ala Leu Ser Asn 
    370                 375                 380                 


Ala Ser Val Leu Glu Asp Ser Arg Pro Gly Ala Asp Ile Val Val Ala 
385                 390                 395                 400 


Tyr Leu Glu Ser Leu Asp Asp Lys Glu Leu Glu Ser Leu Asp Lys Val 
                405                 410                 415     


Gly Leu Pro Ala Gly Arg Ala Ser Tyr Ser Glu Asp Ser Leu Glu Arg 
            420                 425                 430         


Leu Thr Glu Arg Met Leu Arg Asp Asp Cys Asp Leu Phe Glu Ala Arg 
        435                 440                 445             


Lys Arg Glu Phe Asn Val Ala Asp Asp Trp Lys Pro Pro Ala Asp Pro 
    450                 455                 460                 


Ile Tyr Ala Pro Val Gly Asn Pro Gly Val Asp Arg Val Leu Lys Ile 
465                 470                 475                 480 


Val Asn Arg Leu Leu Met Ala Ala Glu Arg Glu Trp Gly Ala Pro Thr 
                485                 490                 495     


Gln Ile Asn Ile Glu His Val Arg Ser Gly Phe Ser Ser Glu Leu Met 
            500                 505                 510         


Gln Arg Glu Phe Glu Arg Glu Asn Glu Arg Arg Arg Ala Gln Asn Glu 
        515                 520                 525             


Glu Ala Val Lys Ala Ile Leu Thr Glu Lys Gly Gly Asn Ser Arg Val 
    530                 535                 540                 


Ser Lys Tyr Asp Ile Thr Arg Tyr Tyr Ala Val Lys Arg Gln His Cys 
545                 550                 555                 560 


Gln Cys Leu Tyr Cys Gly Thr Pro Ile Thr Phe Ser Asp Cys Glu Leu 
                565                 570                 575     


Asp His Ile Val Pro Arg Lys Gly Val Gly Ser Thr Asn Thr Arg Val 
            580                 585                 590         


Asn Leu Ala Ala Ala Cys Arg Ser Cys Asn Arg Asp Lys Ser Asn Leu 
        595                 600                 605             


Pro Phe Ala Val Trp Ala Gly Lys Ala Ser Asn Phe Asp Val Ser Ile 
    610                 615                 620                 


Asp Asp Ala Val Ser Arg Val Lys Gln Trp Gln Arg Ser Gln Asn Glu 
625                 630                 635                 640 


Gly Val Arg Glu Phe Arg Ala Phe Gln Asn Glu Val Ile Ser Arg Leu 
                645                 650                 655     


Leu Lys Thr Thr Glu Asp Pro Glu Ile Asp Ser Arg Ser Leu Glu Ser 
            660                 665                 670         


Val Ala Trp Met Ala Arg Glu Leu His His Arg Val Glu Tyr Tyr Phe 
        675                 680                 685             


Gln Ser Lys Gly Ala Gln Thr Gln Val Ser Val Tyr Arg Gly Ala Val 
    690                 695                 700                 


Thr Ala Gln Ala Arg Lys Ser Ser Gly Leu Glu Asp Lys Val Lys Met 
705                 710                 715                 720 


Ile Gly Gly Gly Gly Lys Thr Arg Leu Asp Arg Arg His His Ala Met 
                725                 730                 735     


Asp Ala Ala Thr Ile Ala Leu Met Thr Pro Gly Ile Ser Thr Thr Leu 
            740                 745                 750         


Ser Glu Lys Asn Asn Leu Arg Asp Ala Gln Lys Phe Thr Gly Gln Ser 
        755                 760                 765             


Glu Thr Trp Lys Asp Tyr Cys Gly Arg Thr Glu Thr Ala Arg Lys His 
    770                 775                 780                 


Phe Ala Val Trp Lys Ser Asn Met Glu Arg Leu Thr Asp Leu Phe Asn 
785                 790                 795                 800 


Asp Lys Leu Glu Asn Asp Ala Ile Pro Val Val Gln Pro Leu Arg Leu 
                805                 810                 815     


Arg Leu Ser Asn Ser Lys Ala His Asp Asp Gly Ile Gly Lys Leu Asp 
            820                 825                 830         


Ser Lys Lys Leu Gly Ser Val Trp Ser Leu Ala Asp Ile Asp Arg Ala 
        835                 840                 845             


Ala Thr Pro Gln Ile Trp Thr Ala Leu Thr Arg Cys Asp Asp Phe Asp 
    850                 855                 860                 


Pro Thr Lys Gly Leu Pro Glu Asn Ala Asn Arg Val Ile Arg Ala Gln 
865                 870                 875                 880 


Gly Val Lys Tyr Glu Ser Glu Asp Asn Ile Pro Val Phe Pro Ser Asn 
                885                 890                 895     


Val Ala Ala Ile Ala Val Arg Asp Gly Tyr Ala Glu Ile Gly Ser Thr 
            900                 905                 910         


Ile His His Ala Arg Ile Tyr Arg Ile Asp Asp Gly Lys Lys Thr Phe 
        915                 920                 925             


Tyr Ser Met Ile Arg Val Phe Ala Val Asp Leu Leu Lys His Gln Ala 
    930                 935                 940                 


Glu Asp Leu Phe Thr Val Lys Leu Pro Pro Ser Ala Ile Ser Ile Arg 
945                 950                 955                 960 


Thr Cys Glu Asp Ser Leu Arg Arg Ala Leu Ser Asn Gly Thr Ala Glu 
                965                 970                 975     


Tyr Leu Gly Trp Leu Val Pro Gly Asp Glu Ile Ile Val Asp Thr Ser 
            980                 985                 990         


Asp Lys Ala Phe His Thr Gly Gln  Ile Gly Asp Leu Leu  Arg Asn Phe 
        995                 1000                 1005             


Pro Val  Asn Ser Phe Arg Leu  Thr Gly Phe Pro Ser  Asn Ser Arg 
    1010                 1015                 1020             


Leu Arg  Leu Lys Pro Val Leu  Leu Ala Gly Glu Gly  Leu Arg Asp 
    1025                 1030                 1035             


Asp Ala  Glu Asp Ser Ile Lys  Lys Ile Leu Leu Gly  Gln Gly Trp 
    1040                 1045                 1050             


Arg Pro  Ala Ile Asn Val Leu  Phe Ser Lys Gly Lys  Pro Arg Ile 
    1055                 1060                 1065             


Val Arg  Arg Asn Ser Leu Gly  Ile Glu Arg Pro Ser  Ser Asn Asn 
    1070                 1075                 1080             


Gly Leu  Pro Phe Ser Trp Glu  Ala 
    1085                 1090     


<210> 321
<211> 1091
<212> PRT
<213> Mobiluncus mulieris


<220>
<223> Mobiluncus mulieris FB024-16

<400> 321
Met Asp Ser Arg Lys Tyr Arg Val Gly Ile Asp Val Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Phe Ala Ala Val Glu Glu Asp Asp Ser Gly Ser Pro Thr Arg 
            20                  25                  30          


Phe Leu Asn Thr Met Val Val Ile His Asp Ser Gly Val Asp Ser Glu 
        35                  40                  45              


Gln Lys Lys Tyr Ala Ile Thr Arg Leu Ala Ser Ala Gly Thr Ala Arg 
    50                  55                  60                  


Arg Thr Arg Arg Leu Tyr Arg Thr Arg Arg Gln Arg Leu Arg Glu Leu 
65                  70                  75                  80  


Asp Asp Phe Ile Ser Asn Glu Leu Gly Tyr Pro Leu Val Asn Leu Glu 
                85                  90                  95      


Asn Phe Ala Asp Pro Tyr Glu Pro Trp Lys Val Arg Ala Asp Leu Ala 
            100                 105                 110         


Thr Thr Lys Leu Pro Asn Asp Glu Leu Pro Glu Ala Met Ser Ile Ala 
        115                 120                 125             


Leu Arg His Met Ala Arg His Arg Gly Trp Arg Ser Pro Tyr Gln Arg 
    130                 135                 140                 


Val Glu Ala Leu His Leu His Ala Glu Ile Ser Lys Glu Phe Ala Ala 
145                 150                 155                 160 


Leu Lys Glu Arg Val Val Glu Lys Thr Gly Asp Val Phe Ser Asp Asp 
                165                 170                 175     


Ala Thr Pro Ala Glu Val Leu Val Asp Leu Met Gly Arg Gln Lys Val 
            180                 185                 190         


Arg Gly Ala Asp Gly Val Leu Ser Gly Lys Leu Arg Gln Ser Asp Asn 
        195                 200                 205             


Ala Asn Glu Leu Arg Lys Ile Ala Ser Val Gln Gly Ile Asp Asp Glu 
    210                 215                 220                 


Thr Leu Asn Arg Ile Ile Asp Arg Val Phe Ser Ser Lys Ser Pro Lys 
225                 230                 235                 240 


Gly Lys Ala Ser Glu Arg Val Gly Met Asp Ala Leu Pro Gly Gln Gly 
                245                 250                 255     


Ser Lys Pro Arg Ala Leu Lys Ala Met Pro Ser Phe Gln Lys Phe Arg 
            260                 265                 270         


Val Val Ser Val Ile Cys Asn Leu Arg Ile Lys Asp Ser Gly Gly Asp 
        275                 280                 285             


Ala Arg Pro Leu Ser Met Glu Glu Lys Glu Lys Leu Ile Asp Tyr Leu 
    290                 295                 300                 


Met Ser Ser Thr Thr Asp Asp His Val Thr Trp Thr Asp Val Ala Asp 
305                 310                 315                 320 


Leu Leu His Val Lys Arg Ser Gln Leu Gln Gly Thr Ala Lys Glu Gly 
                325                 330                 335     


Phe Asp Gly Glu Arg Pro Tyr Thr Arg Pro Pro Val Asn Ser Thr Trp 
            340                 345                 350         


Ser Lys Ile Lys Asp Ser Lys Ile Lys Ser Leu Val Ala Leu Trp Lys 
        355                 360                 365             


Thr Gly Asp Val Asp Val Gln Ser Ala Ile Val Glu Ala Leu Ser Asn 
    370                 375                 380                 


Ala Ser Val Leu Glu Asp Ser Arg Pro Gly Ala Asp Ile Val Val Ala 
385                 390                 395                 400 


Tyr Leu Glu Ser Leu Asp Asp Lys Glu Leu Glu Ser Leu Asp Lys Val 
                405                 410                 415     


Gly Leu Pro Ala Gly Arg Ala Ser Tyr Ser Glu Asp Ser Leu Glu Arg 
            420                 425                 430         


Leu Thr Glu Arg Met Leu Arg Asp Asp Cys Asp Leu Phe Glu Ala Arg 
        435                 440                 445             


Lys Arg Glu Phe Asn Val Ala Asp Asp Trp Lys Pro Pro Ala Asp Pro 
    450                 455                 460                 


Ile Tyr Ala Pro Val Gly Asn Pro Gly Val Asp Arg Val Leu Lys Ile 
465                 470                 475                 480 


Val Asn Arg Leu Leu Met Ala Ala Glu Arg Glu Trp Gly Ala Pro Thr 
                485                 490                 495     


Gln Ile Asn Ile Glu His Val Arg Ser Gly Phe Ser Ser Glu Leu Met 
            500                 505                 510         


Gln Arg Glu Phe Glu Arg Glu Asn Glu Arg Arg Arg Ala Gln Asn Glu 
        515                 520                 525             


Glu Ala Val Lys Ala Ile Leu Thr Glu Lys Gly Gly Asn Ser Arg Val 
    530                 535                 540                 


Ser Lys Tyr Asp Ile Thr Arg Tyr Tyr Ala Val Lys Arg Gln His Cys 
545                 550                 555                 560 


Gln Cys Leu Tyr Cys Gly Thr Pro Ile Thr Phe Ser Asp Cys Glu Leu 
                565                 570                 575     


Asp His Ile Val Pro Arg Lys Gly Val Gly Ser Thr Asn Thr Arg Val 
            580                 585                 590         


Asn Leu Ala Ala Ala Cys Arg Ser Cys Asn Arg Asp Lys Ser Asn Leu 
        595                 600                 605             


Pro Phe Ala Val Trp Ala Gly Lys Ala Ser Asn Phe Asp Val Ser Ile 
    610                 615                 620                 


Asp Asp Ala Val Ser Arg Val Lys Gln Trp Gln Arg Ser Gln Asn Glu 
625                 630                 635                 640 


Gly Val Arg Glu Phe Arg Ala Phe Gln Asn Glu Val Ile Ser Arg Leu 
                645                 650                 655     


Leu Lys Thr Thr Glu Asp Pro Glu Ile Asp Ser Arg Ser Leu Glu Ser 
            660                 665                 670         


Val Ala Trp Met Ala Arg Glu Leu His His Arg Val Glu Tyr Tyr Phe 
        675                 680                 685             


Gln Ser Lys Gly Ala Gln Thr Gln Val Ser Val Tyr Arg Gly Ala Val 
    690                 695                 700                 


Thr Ala Gln Ala Arg Lys Ser Ser Gly Leu Glu Asp Lys Val Lys Met 
705                 710                 715                 720 


Ile Gly Gly Gly Gly Lys Thr Arg Leu Asp Arg Arg His His Ala Met 
                725                 730                 735     


Asp Ala Ala Thr Ile Ala Leu Met Thr Pro Gly Ile Ser Thr Thr Leu 
            740                 745                 750         


Ser Glu Lys Asn Asn Leu Arg Asp Ala Gln Lys Phe Thr Gly Gln Ser 
        755                 760                 765             


Glu Thr Trp Lys Asp Tyr Cys Gly Arg Thr Glu Thr Ala Arg Lys His 
    770                 775                 780                 


Phe Ala Val Trp Lys Ser Asn Met Glu Arg Leu Thr Asp Leu Phe Asn 
785                 790                 795                 800 


Asp Lys Leu Glu Asn Asp Ala Ile Pro Val Val Gln Pro Leu Arg Leu 
                805                 810                 815     


Arg Leu Ser Asn Ser Lys Ala His Asp Asp Gly Ile Gly Lys Leu Asp 
            820                 825                 830         


Ser Lys Lys Leu Gly Ser Val Trp Ser Leu Ala Asp Ile Asp Arg Ala 
        835                 840                 845             


Ala Thr Pro Gln Ile Trp Thr Ala Leu Thr Arg Cys Asp Asp Phe Asp 
    850                 855                 860                 


Pro Thr Lys Gly Leu Pro Glu Asn Ala Asn Arg Val Ile Arg Ala Gln 
865                 870                 875                 880 


Gly Val Lys Tyr Glu Ser Glu Asp Asn Ile Pro Val Phe Pro Ser Asn 
                885                 890                 895     


Val Ala Ala Ile Ala Val Arg Asp Gly Tyr Ala Glu Ile Gly Ser Thr 
            900                 905                 910         


Ile His His Ala Arg Ile Tyr Arg Ile Asp Asp Gly Lys Lys Thr Phe 
        915                 920                 925             


Tyr Ser Met Ile Arg Val Phe Ala Val Asp Leu Leu Lys His Gln Ala 
    930                 935                 940                 


Glu Asp Leu Phe Thr Val Lys Leu Pro Pro Ser Ala Ile Ser Ile Arg 
945                 950                 955                 960 


Thr Cys Glu Asp Ser Leu Arg Arg Ala Leu Ser Asn Gly Thr Ala Glu 
                965                 970                 975     


Tyr Leu Gly Trp Leu Val Pro Gly Asp Glu Ile Ile Val Asp Thr Ser 
            980                 985                 990         


Asp Lys Ala Phe His Thr Gly Gln  Ile Gly Asp Leu Leu  Arg Asn Phe 
        995                 1000                 1005             


Pro Val  Asn Ser Phe Arg Leu  Thr Gly Phe Pro Ser  Asn Ser Arg 
    1010                 1015                 1020             


Leu Arg  Leu Lys Pro Val Leu  Leu Ala Gly Glu Gly  Leu Arg Asp 
    1025                 1030                 1035             


Asp Ala  Glu Asp Ser Ile Lys  Lys Ile Leu Leu Gly  Gln Gly Trp 
    1040                 1045                 1050             


Arg Pro  Ala Ile Asn Val Leu  Phe Ser Lys Gly Lys  Pro Arg Ile 
    1055                 1060                 1065             


Val Arg  Arg Asn Ser Leu Gly  Ile Glu Arg Pro Ser  Ser Asn Asn 
    1070                 1075                 1080             


Gly Leu  Pro Phe Ser Trp Glu  Ala 
    1085                 1090     


<210> 322
<211> 1473
<212> PRT
<213> Mucilaginibacter paludis


<220>
<223> Mucilaginibacter paludis DSM 18603

<400> 322
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Ile Glu Lys Asp Thr Asp Gln Lys Asn Gly Asn Ile Leu Gly 
            20                  25                  30          


Thr Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Ile Lys Asp Glu Phe 
        35                  40                  45              


Gly Lys Gly Asn Ser Ile Ser Gln Thr Ala Asp Arg Thr Lys Phe Arg 
    50                  55                  60                  


Ser Val Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu Asn Val Leu Gly Phe Leu Pro Lys His Tyr Ala Asp 
                85                  90                  95      


Gln Ile Asp Phe Lys Lys Arg Leu Gly Lys Leu Val Asn Glu Thr Glu 
            100                 105                 110         


Pro Lys Leu Val Tyr Asp Asn Lys Asn Phe Ile Phe Lys Lys Ser Phe 
        115                 120                 125             


Glu Ala Met Leu Ser Asp Phe Asn Gln His Gln Pro Leu Leu Leu Ala 
    130                 135                 140                 


Asp Gly Lys Lys Val Pro Phe Asp Trp Thr Ile Tyr Tyr Leu Arg Lys 
145                 150                 155                 160 


Lys Ala Leu Thr Glu Lys Ile Glu Lys Glu Glu Leu Ala Trp Leu Ile 
                165                 170                 175     


Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu 
            180                 185                 190         


Glu Glu Glu Asn Pro Asn Lys Met Val Ala Phe His Ser Leu Lys Ile 
        195                 200                 205             


Val Glu Val Ile Ala Asp Glu Ser Gln Lys Gly Lys Ala Glu Thr Trp 
    210                 215                 220                 


Tyr Ser Leu Ile Leu Glu Asn Gly Trp Ile Tyr Arg Arg Ser Ser Lys 
225                 230                 235                 240 


Thr Pro Leu Tyr Asp Trp Lys Gly Lys Gln Arg Asp Phe Ile Val Thr 
                245                 250                 255     


Thr Asp Leu Asn Asp Asp Gly Ser Ile Lys Thr Asp Lys Glu Gly Leu 
            260                 265                 270         


Glu Lys Arg Ser Phe Arg Ala Pro Val Glu Asp Asp Trp Thr Leu Val 
        275                 280                 285             


Lys Lys Lys Thr Glu Gln Glu Ile Asn Arg Ser His Lys Thr Val Gly 
    290                 295                 300                 


Thr Tyr Ile Tyr Glu Asn Leu Leu Gln Asp Pro Lys Gln Lys Ile Lys 
305                 310                 315                 320 


Gly Lys Leu Val Arg Thr Ile Glu Arg Glu Phe Tyr Lys Asp Glu Leu 
                325                 330                 335     


Lys Met Ile Leu Lys Asn Gln Gln Lys Phe His Pro Glu Leu Asn Asp 
            340                 345                 350         


Glu His Leu Tyr Ile Asn Cys Val Arg Glu Leu Tyr Arg Asn Asn Gln 
        355                 360                 365             


Ala His Gln Thr Ile Leu Ser Lys Lys Asp Phe Val His Leu Phe Ile 
    370                 375                 380                 


Asp Asp Ile Ile Phe Tyr Gln Arg Pro Leu Arg Ser Gln Lys Ser Ser 
385                 390                 395                 400 


Ile Ser Asn Cys Thr Leu Glu Phe Arg Lys Tyr Lys Asn Glu Asn Gly 
                405                 410                 415     


Thr Asp Gln Thr Asp Tyr Leu Lys Ala Ile Pro Lys Ser His Pro Leu 
            420                 425                 430         


Phe Gln Glu Phe Arg Leu Trp Gln Trp Ile Tyr Asn Leu Gly Ile Tyr 
        435                 440                 445             


Gln Lys Glu Asp Asp Thr Asn Val Thr Asp Glu Leu Ile Lys Asn Ile 
    450                 455                 460                 


Asp Gly Tyr Gln Asp Leu Phe Asp Phe Leu Asn Asn Lys Lys Glu Ile 
465                 470                 475                 480 


Arg Gln Asp Ile Leu Ile Lys Phe Leu Val Glu Gln Thr Gly Leu Lys 
                485                 490                 495     


Gly Lys Pro Leu Ser Ser Val Val Ala Lys Tyr Arg Trp Asn Phe Val 
            500                 505                 510         


Glu Asp Lys Ile Tyr Pro Cys Asn Glu Thr Gly Thr Gln Ile Arg Thr 
        515                 520                 525             


Arg Leu Ala Lys Val Glu Asn Thr Pro Glu Asp Phe Leu Thr Ala Glu 
    530                 535                 540                 


Thr Glu Ile Lys Leu Trp His Ile Ile Tyr Ser Val Asn Asp Lys Ala 
545                 550                 555                 560 


Asp Tyr Glu Lys Ala Leu Lys Thr Phe Ala Glu Lys His Asn Leu Asp 
                565                 570                 575     


Thr His Ser Phe Val Glu Asn Phe Lys Lys Phe Pro Pro Phe Lys Ser 
            580                 585                 590         


Glu Tyr Gly Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro Leu 
        595                 600                 605             


Ile Arg Leu Gly Lys Tyr Trp Ser Trp Glu Asn Ile Asp Lys Lys Thr 
    610                 615                 620                 


Gln Glu Arg Ile Glu Lys Ile Leu Thr Gly Glu Phe Asp Glu Ala Ile 
625                 630                 635                 640 


Lys Ser Arg Val Arg Asp Lys Ala Ile His Leu Thr Glu Glu Asp His 
                645                 650                 655     


Phe Gln Gly Leu Gln Leu Trp Leu Ala Ser Tyr Val Val Tyr Gly Arg 
            660                 665                 670         


His Ser Glu Ala Asp Asn Leu Asp Lys Trp His Thr Val Ala Asp Leu 
        675                 680                 685             


Glu Asp Tyr Leu Ala Glu Phe Arg Gln His Ser Leu Arg Asn Pro Ile 
    690                 695                 700                 


Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val Val Lys Asp Ile Trp 
705                 710                 715                 720 


Leu Gln Tyr Gly Gln Gly Ala Lys Asp Phe Phe Ser Glu Ile His Ile 
                725                 730                 735     


Glu Leu Ala Arg Glu Met Lys Asn Thr Gly Asp Glu Arg Lys Arg Leu 
            740                 745                 750         


Thr Ser Leu Val Thr Asp Asn Glu Asn Thr Asn Leu Arg Ile Lys Val 
        755                 760                 765             


Leu Leu Ser Glu Leu Leu Asn Asp Gly Asn Val Glu Asn Val Arg Pro 
    770                 775                 780                 


Tyr Ser Pro Met Gln Gln Glu Ala Leu Lys Ile Phe Glu Asp Gly Val 
785                 790                 795                 800 


Leu Asn Ser Asp Ile Glu Ile Glu Asp Asp Ile Leu Lys Ile Ser Lys 
                805                 810                 815     


Met Ala Gln Pro Thr Asn Thr Glu Leu Lys Arg Tyr Lys Leu Trp Leu 
            820                 825                 830         


Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Gln Ile Ile Pro Leu Asn 
        835                 840                 845             


Arg Leu Phe Thr Ala Asp Tyr Glu Ile Glu His Ile Ile Pro Gln Ser 
    850                 855                 860                 


Arg Phe Phe Asp Asp Ser Phe Ser Asn Lys Ile Ile Cys Glu Ser Ala 
865                 870                 875                 880 


Val Asn Gln Leu Lys Asp Lys Gln Leu Gly Leu Glu Phe Ile Lys Asn 
                885                 890                 895     


His Ser Gly Thr Ile Val Lys Leu Gly Met Gly Lys Thr Ala Lys Ile 
            900                 905                 910         


Leu Asp Val Glu Ser Tyr Asn Glu Phe Val Lys Gly Asn Tyr Thr Lys 
        915                 920                 925             


Asn Ile Ser Lys Arg Asn Lys Leu Met Leu Glu Glu Ile Pro Asp Lys 
    930                 935                 940                 


Met Ile Glu Arg Gln Leu Asn Asp Thr Arg Tyr Ile Ser Lys Phe Ile 
945                 950                 955                 960 


Ile Ser Ala Leu Ser Asn Ile Val Arg Ser Glu Ser Asn Asp Asp Gly 
                965                 970                 975     


Phe Asn Ser Lys Asn Val Leu Pro Gly Asn Gly Lys Ile Thr Ser Arg 
            980                 985                 990         


Leu Lys Gln Asp Trp Gly Met Asn  Asp Ile Trp Asn Glu  Leu Ile Leu 
        995                 1000                 1005             


Pro Arg  Phe Glu Arg Met Asn  Lys Ile Thr Asp Ser  Ala Val Phe 
    1010                 1015                 1020             


Thr Ala  Trp Asn Glu Asn Asn  Gln Lys Phe Leu Pro  Ile Val Pro 
    1025                 1030                 1035             


Leu Glu  Phe Ser Lys Gly Phe  Gln Lys Lys Arg Ile  Asp His Arg 
    1040                 1045                 1050             


His His  Ala Leu Asp Ala Leu  Val Ile Ala Ala Ser  Thr Arg Glu 
    1055                 1060                 1065             


His Ile  Asn Leu Leu Asn Asn  Glu His Ala Lys Ser  Asp Lys Arg 
    1070                 1075                 1080             


Phe Asp  Leu Asn Arg Lys Leu  Arg Lys Phe Glu Lys  Val Ala Tyr 
    1085                 1090                 1095             


Asn Asp  Pro Lys Thr Gly Lys  Arg Ile Glu Lys Glu  Val Pro Thr 
    1100                 1105                 1110             


Ile Phe  Leu Lys Pro Trp Glu  Thr Phe Thr Val Asp  Ala Lys Asn 
    1115                 1120                 1125             


Ser Leu  Glu Ser Ile Ile Val  Ser Phe Lys Gln Asn  Leu Arg Val 
    1130                 1135                 1140             


Ile Asn  Arg Ala Thr Asn Tyr  Ser Glu Ser Tyr Asn  Asp Glu Asn 
    1145                 1150                 1155             


Gly Ala  Leu Arg Leu Gly Lys  Asp Gly Asn Pro Leu  Lys Glu Lys 
    1160                 1165                 1170             


Ile Lys  Gln Ser Lys Gly Asp  Ser Trp Ala Ile Arg  Lys Pro Met 
    1175                 1180                 1185             


His Lys  Asp Phe Val Tyr Gly  Lys Val His Leu Gln  Asn Val Lys 
    1190                 1195                 1200             


Leu Pro  Lys Asp Lys Phe Ile  Thr Ala Ile Arg Lys  Ser Leu Asp 
    1205                 1210                 1215             


Val Thr  Phe Asp Leu Lys Arg  Ile Glu Thr Ile Thr  Asp Thr Gly 
    1220                 1225                 1230             


Ile Gln  Lys Ile Leu Lys Asn  Tyr Leu His Ser Lys  Glu Asn Lys 
    1235                 1240                 1245             


Val Glu  Leu Ala Phe Ser Pro  Glu Gly Ile Glu Asp  Met Asn Gln 
    1250                 1255                 1260             


His Ile  Glu Arg Tyr Asn Asp  Gly Lys Lys His Gln  Pro Ile His 
    1265                 1270                 1275             


Lys Val  Arg Val Phe Glu Ile  Gly Ser Arg Phe Ser  Leu Gly Glu 
    1280                 1285                 1290             


Ser Gly  Asn Lys Lys Thr Lys  Phe Val Glu Ala Ala  Lys Gly Thr 
    1295                 1300                 1305             


Asn Leu  Phe Phe Ala Val Tyr  Gln Asp Asp Asn Lys  Gly Lys Arg 
    1310                 1315                 1320             


Asn Tyr  Glu Thr Ile Pro Leu  Asn Ile Val Ile Glu  Arg Gln Lys 
    1325                 1330                 1335             


Leu Gly  Leu His Ser Val Pro  Thr Glu Asp Ala Lys  Gly Gly Lys 
    1340                 1345                 1350             


Leu Leu  Phe His Leu Ser Pro  Asn Asp Met Val Tyr  Val Pro Thr 
    1355                 1360                 1365             


Ser Glu  Glu Leu Glu Asp Asn  Leu Ala Ser Val Asn  Ile Lys Arg 
    1370                 1375                 1380             


Leu Asn  Thr Ala Gln Arg Lys  Arg Ile Tyr Lys Val  Glu Lys Ala 
    1385                 1390                 1395             


Ser Gly  Val Glu Cys Tyr Phe  Ile Arg Gln Asp Ile  Ala Tyr Leu 
    1400                 1405                 1410             


Ile Lys  Asn Tyr Asp Ala Lys  Thr Lys Ile Gly Glu  Leu Glu Ser 
    1415                 1420                 1425             


Gln Asn  Lys Leu Gln Thr Thr  Met Thr Asp Asp Arg  Leu Lys Ile 
    1430                 1435                 1440             


Thr Asp  Val Cys Val Lys Leu  Asn Ile Asp Arg Leu  Gly Ser Ile 
    1445                 1450                 1455             


Ala Glu  Thr Phe Leu Gly Asn  Gln Tyr Gly Ala Ser  Lys Lys Thr 
    1460                 1465                 1470             


<210> 323
<211> 1233
<212> PRT
<213> Mycoplasma canis


<220>
<223> Mycoplasma canis PG 14

<400> 323
Met Glu Lys Lys Arg Lys Val Thr Leu Gly Phe Asp Leu Gly Ile Ala 
1               5                   10                  15      


Ser Val Gly Trp Ala Ile Val Asp Ser Glu Thr Asn Gln Val Tyr Lys 
            20                  25                  30          


Leu Gly Ser Arg Leu Phe Asp Ala Pro Asp Thr Asn Leu Glu Arg Arg 
        35                  40                  45              


Thr Gln Arg Gly Thr Arg Arg Leu Leu Arg Arg Arg Lys Tyr Arg Asn 
    50                  55                  60                  


Gln Lys Phe Tyr Asn Leu Val Lys Arg Thr Glu Val Phe Gly Leu Ser 
65                  70                  75                  80  


Ser Arg Glu Ala Ile Glu Asn Arg Phe Arg Glu Leu Ser Ile Lys Tyr 
                85                  90                  95      


Pro Asn Ile Ile Glu Leu Lys Thr Lys Ala Leu Ser Gln Glu Val Cys 
            100                 105                 110         


Pro Asp Glu Ile Ala Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 
        115                 120                 125             


Tyr Phe Tyr Asp Glu Lys Glu Thr Lys Glu Asp Phe Asp Gln Gln Thr 
    130                 135                 140                 


Val Glu Ser Met Pro Ser Tyr Lys Leu Asn Glu Phe Tyr Lys Lys Tyr 
145                 150                 155                 160 


Gly Tyr Phe Lys Gly Ala Leu Ser Gln Pro Thr Glu Ser Glu Met Lys 
                165                 170                 175     


Asp Asn Lys Asp Leu Lys Glu Ala Phe Phe Phe Asp Phe Ser Asn Lys 
            180                 185                 190         


Glu Trp Leu Lys Glu Ile Asn Tyr Phe Phe Asn Val Gln Lys Asn Ile 
        195                 200                 205             


Leu Ser Glu Thr Phe Ile Glu Glu Phe Lys Lys Ile Phe Ser Phe Thr 
    210                 215                 220                 


Arg Asp Ile Ser Lys Gly Pro Gly Ser Asp Asn Met Pro Ser Pro Tyr 
225                 230                 235                 240 


Gly Ile Phe Gly Glu Phe Gly Asp Asn Gly Gln Gly Gly Arg Tyr Glu 
                245                 250                 255     


His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Thr Asn Glu 
            260                 265                 270         


Gln Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Ile Phe Asn Phe Leu 
        275                 280                 285             


Asn Glu Leu Ala Asn Ile Arg Leu Tyr Ser Thr Asp Lys Lys Asn Ile 
    290                 295                 300                 


Gln Pro Leu Trp Lys Leu Ser Ser Val Asp Lys Leu Asn Ile Leu Leu 
305                 310                 315                 320 


Asn Leu Phe Asn Leu Pro Ile Ser Glu Lys Lys Lys Lys Leu Thr Ser 
                325                 330                 335     


Thr Asn Ile Asn Asp Ile Val Lys Lys Glu Ser Ile Lys Ser Ile Met 
            340                 345                 350         


Ile Ser Val Glu Asp Ile Asp Met Ile Lys Asp Glu Trp Ala Gly Lys 
        355                 360                 365             


Glu Pro Asn Val Tyr Gly Val Gly Leu Ser Gly Leu Asn Ile Glu Glu 
    370                 375                 380                 


Ser Ala Lys Glu Asn Lys Phe Lys Phe Gln Asp Leu Lys Ile Leu Asn 
385                 390                 395                 400 


Val Leu Ile Asn Leu Leu Asp Asn Val Gly Ile Lys Phe Glu Phe Lys 
                405                 410                 415     


Asp Arg Asn Asp Ile Ile Lys Asn Leu Glu Leu Leu Asp Asn Leu Tyr 
            420                 425                 430         


Leu Phe Leu Ile Tyr Gln Lys Glu Ser Asn Asn Lys Asp Ser Ser Ile 
        435                 440                 445             


Asp Leu Phe Ile Ala Lys Asn Glu Ser Leu Asn Ile Glu Asn Leu Lys 
    450                 455                 460                 


Leu Lys Leu Lys Glu Phe Leu Leu Gly Ala Gly Asn Glu Phe Glu Asn 
465                 470                 475                 480 


His Asn Ser Lys Thr His Ser Leu Ser Lys Lys Ala Ile Asp Glu Ile 
                485                 490                 495     


Leu Pro Lys Leu Leu Asp Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 
            500                 505                 510         


Lys Asn Tyr Asp Glu Glu Ile Lys Ser Gln Ile Glu Asp Asn Ser Ser 
        515                 520                 525             


Leu Met Ala Lys Gln Asp Lys Lys Tyr Leu Asn Asp Asn Phe Leu Lys 
    530                 535                 540                 


Asp Ala Ile Leu Pro Pro Asn Val Lys Val Thr Phe Gln Gln Ala Ile 
545                 550                 555                 560 


Leu Ile Phe Asn Lys Ile Ile Gln Lys Phe Ser Lys Asp Phe Glu Ile 
                565                 570                 575     


Asp Lys Val Val Ile Glu Leu Ala Arg Glu Met Thr Gln Asp Gln Glu 
            580                 585                 590         


Asn Asp Ala Leu Lys Gly Ile Ala Lys Ala Gln Lys Ser Lys Lys Ser 
        595                 600                 605             


Leu Val Glu Glu Arg Leu Glu Ala Asn Asn Ile Asp Lys Ser Val Phe 
    610                 615                 620                 


Asn Asp Lys Tyr Glu Lys Leu Ile Tyr Lys Ile Phe Leu Trp Ile Ser 
625                 630                 635                 640 


Gln Asp Phe Lys Asp Pro Tyr Thr Gly Ala Gln Ile Ser Val Asn Glu 
                645                 650                 655     


Ile Val Asn Asn Lys Val Glu Ile Asp His Ile Ile Pro Tyr Ser Leu 
            660                 665                 670         


Cys Phe Asp Asp Ser Ser Ala Asn Lys Val Leu Val His Lys Gln Ser 
        675                 680                 685             


Asn Gln Glu Lys Ser Asn Ser Leu Pro Tyr Glu Tyr Ile Lys Gln Gly 
    690                 695                 700                 


His Ser Gly Trp Asn Trp Asp Glu Phe Thr Lys Tyr Val Lys Arg Val 
705                 710                 715                 720 


Phe Val Asn Asn Val Asp Ser Ile Leu Ser Lys Lys Glu Arg Leu Lys 
                725                 730                 735     


Lys Ser Glu Asn Leu Leu Thr Ala Ser Tyr Asp Gly Tyr Asp Lys Leu 
            740                 745                 750         


Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Leu 
        755                 760                 765             


Phe Arg Asp Gln Leu Asn Asn Tyr Ala Glu His His Leu Ile Asp Asn 
    770                 775                 780                 


Lys Lys Met Phe Lys Val Ile Ala Met Asn Gly Ala Val Thr Ser Phe 
785                 790                 795                 800 


Ile Arg Lys Asn Met Ser Tyr Asp Asn Lys Leu Arg Leu Lys Asp Arg 
                805                 810                 815     


Ser Asp Phe Ser His His Ala Tyr Asp Ala Ala Ile Ile Ala Leu Phe 
            820                 825                 830         


Ser Asn Lys Thr Lys Thr Leu Tyr Asn Leu Ile Asp Pro Ser Leu Asn 
        835                 840                 845             


Gly Ile Ile Ser Lys Arg Ser Glu Gly Tyr Trp Val Ile Glu Asp Arg 
    850                 855                 860                 


Tyr Thr Gly Glu Ile Lys Glu Leu Lys Lys Glu Asp Trp Thr Ser Ile 
865                 870                 875                 880 


Lys Asn Asn Val Gln Ala Arg Lys Ile Ala Lys Glu Ile Glu Glu Tyr 
                885                 890                 895     


Leu Ile Asp Leu Asp Asp Glu Val Phe Phe Ser Arg Lys Thr Lys Arg 
            900                 905                 910         


Lys Thr Asn Arg Gln Leu Tyr Asn Glu Thr Ile Tyr Gly Ile Ala Thr 
        915                 920                 925             


Lys Thr Asp Glu Asp Gly Ile Thr Asn Tyr Tyr Lys Lys Glu Lys Phe 
    930                 935                 940                 


Ser Ile Leu Asp Asp Lys Asp Ile Tyr Leu Arg Leu Leu Arg Glu Arg 
945                 950                 955                 960 


Glu Lys Phe Val Ile Asn Gln Ser Asn Pro Glu Val Ile Asp Gln Ile 
                965                 970                 975     


Ile Glu Ile Ile Glu Ser Tyr Gly Lys Glu Asn Asn Ile Pro Ser Arg 
            980                 985                 990         


Asp Glu Ala Ile Asn Ile Lys Tyr  Thr Lys Asn Lys Ile  Asn Tyr Asn 
        995                 1000                 1005             


Leu Tyr  Leu Lys Gln Tyr Met  Arg Ser Leu Thr Lys  Ser Leu Asp 
    1010                 1015                 1020             


Gln Phe  Ser Glu Glu Phe Ile  Asn Gln Met Ile Ala  Asn Lys Thr 
    1025                 1030                 1035             


Phe Val  Leu Tyr Asn Pro Thr  Lys Asn Thr Thr Arg  Lys Ile Lys 
    1040                 1045                 1050             


Phe Leu  Arg Leu Val Asn Asp  Val Lys Ile Asn Asp  Ile Arg Lys 
    1055                 1060                 1065             


Asn Gln  Val Ile Asn Lys Phe  Asn Gly Lys Asn Asn  Glu Pro Lys 
    1070                 1075                 1080             


Ala Phe  Tyr Glu Asn Ile Asn  Ser Leu Gly Ala Ile  Val Phe Lys 
    1085                 1090                 1095             


Asn Ser  Ala Asn Asn Phe Lys  Thr Leu Ser Ile Asn  Thr Gln Ile 
    1100                 1105                 1110             


Ala Ile  Phe Gly Asp Lys Asn  Trp Asp Ile Glu Asp  Phe Lys Thr 
    1115                 1120                 1125             


Tyr Asn  Met Glu Lys Ile Glu  Lys Tyr Lys Glu Ile  Tyr Gly Ile 
    1130                 1135                 1140             


Asp Lys  Thr Tyr Asn Phe His  Ser Phe Ile Phe Pro  Gly Thr Ile 
    1145                 1150                 1155             


Leu Leu  Asp Lys Gln Asn Lys  Glu Phe Tyr Tyr Ile  Ser Ser Ile 
    1160                 1165                 1170             


Gln Thr  Val Arg Asp Ile Ile  Glu Ile Lys Phe Leu  Asn Lys Ile 
    1175                 1180                 1185             


Glu Phe  Lys Asp Glu Asn Lys  Asn Gln Asp Thr Ser  Lys Thr Pro 
    1190                 1195                 1200             


Lys Arg  Leu Met Phe Gly Ile  Lys Ser Ile Met Asn  Asn Tyr Glu 
    1205                 1210                 1215             


Gln Val  Asp Ile Ser Pro Phe  Gly Ile Asn Lys Lys  Ile Phe Glu 
    1220                 1225                 1230             


<210> 324
<211> 1233
<212> PRT
<213> Mycoplasma canis


<220>
<223> Mycoplasma canis PG 14

<400> 324
Met Glu Lys Lys Arg Lys Val Thr Leu Gly Phe Asp Leu Gly Ile Ala 
1               5                   10                  15      


Ser Val Gly Trp Ala Ile Val Asp Ser Glu Thr Asn Gln Val Tyr Lys 
            20                  25                  30          


Leu Gly Ser Arg Leu Phe Asp Ala Pro Asp Thr Asn Leu Glu Arg Arg 
        35                  40                  45              


Thr Gln Arg Gly Thr Arg Arg Leu Leu Arg Arg Arg Lys Tyr Arg Asn 
    50                  55                  60                  


Gln Lys Phe Tyr Asn Leu Val Lys Arg Thr Glu Val Phe Gly Leu Ser 
65                  70                  75                  80  


Ser Arg Glu Ala Ile Glu Asn Arg Phe Arg Glu Leu Ser Ile Lys Tyr 
                85                  90                  95      


Pro Asn Ile Ile Glu Leu Lys Thr Lys Ala Leu Ser Gln Glu Val Cys 
            100                 105                 110         


Pro Asp Glu Ile Ala Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 
        115                 120                 125             


Tyr Phe Tyr Asp Glu Lys Glu Thr Lys Glu Asp Phe Asp Gln Gln Thr 
    130                 135                 140                 


Val Glu Ser Met Pro Ser Tyr Lys Leu Asn Glu Phe Tyr Lys Lys Tyr 
145                 150                 155                 160 


Gly Tyr Phe Lys Gly Ala Leu Ser Gln Pro Thr Glu Ser Glu Met Lys 
                165                 170                 175     


Asp Asn Lys Asp Leu Lys Glu Ala Phe Phe Phe Asp Phe Ser Asn Lys 
            180                 185                 190         


Glu Trp Leu Lys Glu Ile Asn Tyr Phe Phe Asn Val Gln Lys Asn Ile 
        195                 200                 205             


Leu Ser Glu Thr Phe Ile Glu Glu Phe Lys Lys Ile Phe Ser Phe Thr 
    210                 215                 220                 


Arg Asp Ile Ser Lys Gly Pro Gly Ser Asp Asn Met Pro Ser Pro Tyr 
225                 230                 235                 240 


Gly Ile Phe Gly Glu Phe Gly Asp Asn Gly Gln Gly Gly Arg Tyr Glu 
                245                 250                 255     


His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Thr Asn Glu 
            260                 265                 270         


Gln Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Ile Phe Asn Phe Leu 
        275                 280                 285             


Asn Glu Leu Ala Asn Ile Arg Leu Tyr Ser Thr Asp Lys Lys Asn Ile 
    290                 295                 300                 


Gln Pro Leu Trp Lys Leu Ser Ser Val Asp Lys Leu Asn Ile Leu Leu 
305                 310                 315                 320 


Asn Leu Phe Asn Leu Pro Ile Ser Glu Lys Lys Lys Lys Leu Thr Ser 
                325                 330                 335     


Thr Asn Ile Asn Asp Ile Val Lys Lys Glu Ser Ile Lys Ser Ile Met 
            340                 345                 350         


Ile Ser Val Glu Asp Ile Asp Met Ile Lys Asp Glu Trp Ala Gly Lys 
        355                 360                 365             


Glu Pro Asn Val Tyr Gly Val Gly Leu Ser Gly Leu Asn Ile Glu Glu 
    370                 375                 380                 


Ser Ala Lys Glu Asn Lys Phe Lys Phe Gln Asp Leu Lys Ile Leu Asn 
385                 390                 395                 400 


Val Leu Ile Asn Leu Leu Asp Asn Val Gly Ile Lys Phe Glu Phe Lys 
                405                 410                 415     


Asp Arg Asn Asp Ile Ile Lys Asn Leu Glu Leu Leu Asp Asn Leu Tyr 
            420                 425                 430         


Leu Phe Leu Ile Tyr Gln Lys Glu Ser Asn Asn Lys Asp Ser Ser Ile 
        435                 440                 445             


Asp Leu Phe Ile Ala Lys Asn Glu Ser Leu Asn Ile Glu Asn Leu Lys 
    450                 455                 460                 


Leu Lys Leu Lys Glu Phe Leu Leu Gly Ala Gly Asn Glu Phe Glu Asn 
465                 470                 475                 480 


His Asn Ser Lys Thr His Ser Leu Ser Lys Lys Ala Ile Asp Glu Ile 
                485                 490                 495     


Leu Pro Lys Leu Leu Asp Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 
            500                 505                 510         


Lys Asn Tyr Asp Glu Glu Ile Lys Ser Gln Ile Glu Asp Asn Ser Ser 
        515                 520                 525             


Leu Met Ala Lys Gln Asp Lys Lys Tyr Leu Asn Asp Asn Phe Leu Lys 
    530                 535                 540                 


Asp Ala Ile Leu Pro Pro Asn Val Lys Val Thr Phe Gln Gln Ala Ile 
545                 550                 555                 560 


Leu Ile Phe Asn Lys Ile Ile Gln Lys Phe Ser Lys Asp Phe Glu Ile 
                565                 570                 575     


Asp Lys Val Val Ile Glu Leu Ala Arg Glu Met Thr Gln Asp Gln Glu 
            580                 585                 590         


Asn Asp Ala Leu Lys Gly Ile Ala Lys Ala Gln Lys Ser Lys Lys Ser 
        595                 600                 605             


Leu Val Glu Glu Arg Leu Glu Ala Asn Asn Ile Asp Lys Ser Val Phe 
    610                 615                 620                 


Asn Asp Lys Tyr Glu Lys Leu Ile Tyr Lys Ile Phe Leu Trp Ile Ser 
625                 630                 635                 640 


Gln Asp Phe Lys Asp Pro Tyr Thr Gly Ala Gln Ile Ser Val Asn Glu 
                645                 650                 655     


Ile Val Asn Asn Lys Val Glu Ile Asp His Ile Ile Pro Tyr Ser Leu 
            660                 665                 670         


Cys Phe Asp Asp Ser Ser Ala Asn Lys Val Leu Val His Lys Gln Ser 
        675                 680                 685             


Asn Gln Glu Lys Ser Asn Ser Leu Pro Tyr Glu Tyr Ile Lys Gln Gly 
    690                 695                 700                 


His Ser Gly Trp Asn Trp Asp Glu Phe Thr Lys Tyr Val Lys Arg Val 
705                 710                 715                 720 


Phe Val Asn Asn Val Asp Ser Ile Leu Ser Lys Lys Glu Arg Leu Lys 
                725                 730                 735     


Lys Ser Glu Asn Leu Leu Thr Ala Ser Tyr Asp Gly Tyr Asp Lys Leu 
            740                 745                 750         


Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Leu 
        755                 760                 765             


Phe Arg Asp Gln Leu Asn Asn Tyr Ala Glu His His Leu Ile Asp Asn 
    770                 775                 780                 


Lys Lys Met Phe Lys Val Ile Ala Met Asn Gly Ala Val Thr Ser Phe 
785                 790                 795                 800 


Ile Arg Lys Asn Met Ser Tyr Asp Asn Lys Leu Arg Leu Lys Asp Arg 
                805                 810                 815     


Ser Asp Phe Ser His His Ala Tyr Asp Ala Ala Ile Ile Ala Leu Phe 
            820                 825                 830         


Ser Asn Lys Thr Lys Thr Leu Tyr Asn Leu Ile Asp Pro Ser Leu Asn 
        835                 840                 845             


Gly Ile Ile Ser Lys Arg Ser Glu Gly Tyr Trp Val Ile Glu Asp Arg 
    850                 855                 860                 


Tyr Thr Gly Glu Ile Lys Glu Leu Lys Lys Glu Asp Trp Thr Ser Ile 
865                 870                 875                 880 


Lys Asn Asn Val Gln Ala Arg Lys Ile Ala Lys Glu Ile Glu Glu Tyr 
                885                 890                 895     


Leu Ile Asp Leu Asp Asp Glu Val Phe Phe Ser Arg Lys Thr Lys Arg 
            900                 905                 910         


Lys Thr Asn Arg Gln Leu Tyr Asn Glu Thr Ile Tyr Gly Ile Ala Thr 
        915                 920                 925             


Lys Thr Asp Glu Asp Gly Ile Thr Asn Tyr Tyr Lys Lys Glu Lys Phe 
    930                 935                 940                 


Ser Ile Leu Asp Asp Lys Asp Ile Tyr Leu Arg Leu Leu Arg Glu Arg 
945                 950                 955                 960 


Glu Lys Phe Val Ile Asn Gln Ser Asn Pro Glu Val Ile Asp Gln Ile 
                965                 970                 975     


Ile Glu Ile Ile Glu Ser Tyr Gly Lys Glu Asn Asn Ile Pro Ser Arg 
            980                 985                 990         


Asp Glu Ala Ile Asn Ile Lys Tyr  Thr Lys Asn Lys Ile  Asn Tyr Asn 
        995                 1000                 1005             


Leu Tyr  Leu Lys Gln Tyr Met  Arg Ser Leu Thr Lys  Ser Leu Asp 
    1010                 1015                 1020             


Gln Phe  Ser Glu Glu Phe Ile  Asn Gln Met Ile Ala  Asn Lys Thr 
    1025                 1030                 1035             


Phe Val  Leu Tyr Asn Pro Thr  Lys Asn Thr Thr Arg  Lys Ile Lys 
    1040                 1045                 1050             


Phe Leu  Arg Leu Val Asn Asp  Val Lys Ile Asn Asp  Ile Arg Lys 
    1055                 1060                 1065             


Asn Gln  Val Ile Asn Lys Phe  Asn Gly Lys Asn Asn  Glu Pro Lys 
    1070                 1075                 1080             


Ala Phe  Tyr Glu Asn Ile Asn  Ser Leu Gly Ala Ile  Val Phe Lys 
    1085                 1090                 1095             


Asn Ser  Ala Asn Asn Phe Lys  Thr Leu Ser Ile Asn  Thr Gln Ile 
    1100                 1105                 1110             


Ala Ile  Phe Gly Asp Lys Asn  Trp Asp Ile Glu Asp  Phe Lys Thr 
    1115                 1120                 1125             


Tyr Asn  Met Glu Lys Ile Glu  Lys Tyr Lys Glu Ile  Tyr Gly Ile 
    1130                 1135                 1140             


Asp Lys  Thr Tyr Asn Phe His  Ser Phe Ile Phe Pro  Gly Thr Ile 
    1145                 1150                 1155             


Leu Leu  Asp Lys Gln Asn Lys  Glu Phe Tyr Tyr Ile  Ser Ser Ile 
    1160                 1165                 1170             


Gln Thr  Val Arg Asp Ile Ile  Glu Ile Lys Phe Leu  Asn Lys Ile 
    1175                 1180                 1185             


Glu Phe  Lys Asp Glu Asn Lys  Asn Gln Asp Thr Ser  Lys Thr Pro 
    1190                 1195                 1200             


Lys Arg  Leu Met Phe Gly Ile  Lys Ser Ile Met Asn  Asn Tyr Glu 
    1205                 1210                 1215             


Gln Val  Asp Ile Ser Pro Phe  Gly Ile Asn Lys Lys  Ile Phe Glu 
    1220                 1225                 1230             


<210> 325
<211> 1233
<212> PRT
<213> Mycoplasma canis


<220>
<223> Mycoplasma canis UF31

<400> 325
Met Glu Lys Lys Arg Lys Val Thr Leu Gly Phe Asp Leu Gly Ile Ala 
1               5                   10                  15      


Ser Ile Gly Trp Ala Ile Val Asp Ser Glu Thr Asn Gln Val Tyr Lys 
            20                  25                  30          


Leu Gly Ser Arg Leu Phe Asp Ala Pro Asp Thr Asn Leu Glu Arg Arg 
        35                  40                  45              


Thr Gln Arg Gly Thr Arg Arg Leu Leu Arg Arg Arg Lys Tyr Arg Asn 
    50                  55                  60                  


Gln Lys Phe Tyr Asn Leu Val Lys Arg Thr Glu Val Phe Gly Leu Ser 
65                  70                  75                  80  


Ser Arg Glu Ala Ile Glu Asn Arg Phe Arg Glu Leu Ser Ile Lys Tyr 
                85                  90                  95      


Pro Asn Ile Ile Glu Leu Lys Thr Lys Ala Leu Ser Gln Glu Val Cys 
            100                 105                 110         


Pro Asp Glu Ile Ala Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 
        115                 120                 125             


Tyr Phe Tyr Asp Glu Lys Glu Thr Lys Glu Asp Phe Asp Gln Gln Thr 
    130                 135                 140                 


Val Glu Ser Met Pro Ser Tyr Lys Leu Asn Glu Phe Tyr Lys Lys Tyr 
145                 150                 155                 160 


Gly Tyr Phe Lys Gly Ala Leu Ser Gln Pro Thr Glu Ser Glu Met Lys 
                165                 170                 175     


Asp Asn Lys Asp Leu Lys Glu Ala Phe Phe Phe Asp Phe Ser Asn Lys 
            180                 185                 190         


Glu Trp Leu Lys Glu Ile Asn Tyr Phe Phe Asn Val Gln Lys Asn Ile 
        195                 200                 205             


Leu Ser Glu Thr Phe Ile Glu Glu Phe Lys Lys Ile Phe Ser Phe Thr 
    210                 215                 220                 


Arg Asp Ile Ser Lys Gly Pro Gly Ser Asp Asn Met Pro Ser Pro Tyr 
225                 230                 235                 240 


Gly Ile Phe Gly Glu Phe Gly Asp Asn Gly Gln Gly Gly Arg Tyr Glu 
                245                 250                 255     


His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Thr Asn Glu 
            260                 265                 270         


Gln Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Ile Phe Asn Phe Leu 
        275                 280                 285             


Asn Glu Leu Ala Asn Ile Arg Leu Tyr Ser Thr Asp Lys Lys Asn Ile 
    290                 295                 300                 


Gln Pro Leu Trp Lys Leu Ser Ser Ile Asp Lys Leu Asn Ile Leu Leu 
305                 310                 315                 320 


Asn Leu Phe Asn Leu Pro Ile Ser Glu Lys Lys Lys Lys Leu Thr Asn 
                325                 330                 335     


Ala Asn Ile Asn Asp Ile Val Lys Lys Glu Ser Thr Lys Ser Ile Met 
            340                 345                 350         


Leu Ser Val Glu Asp Ile Asp Met Ile Lys Asp Glu Trp Ala Gly Lys 
        355                 360                 365             


Glu Pro Asn Val Tyr Gly Val Gly Leu Ser Gly Leu Asn Ile Glu Glu 
    370                 375                 380                 


Ser Ala Lys Glu Asn Lys Phe Lys Phe Gln Asp Leu Lys Ile Leu Asn 
385                 390                 395                 400 


Val Leu Ile Asn Leu Leu Asp Asn Val Gly Ile Lys Phe Glu Phe Lys 
                405                 410                 415     


Asp Arg Asn Asp Ile Ile Lys Asn Leu Glu Leu Leu Asp Asn Leu Tyr 
            420                 425                 430         


Leu Phe Leu Ile Tyr Gln Lys Glu Ser Asn Asn Lys Asp Ser Ser Ile 
        435                 440                 445             


Asp Leu Phe Ile Ala Lys Asn Glu Leu Leu Asn Ile Glu Asn Leu Lys 
    450                 455                 460                 


Leu Lys Leu Lys Glu Phe Leu Leu Gly Ala Gly Asn Glu Phe Glu Asn 
465                 470                 475                 480 


His Asn Ser Lys Thr His Ser Leu Ser Lys Lys Ala Ile Asp Ala Ile 
                485                 490                 495     


Leu Pro Lys Leu Leu Asp Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 
            500                 505                 510         


Lys Asn Tyr Asp Glu Glu Ile Lys Ser Gln Ile Glu Asp Asn Ser Ser 
        515                 520                 525             


Leu Met Ala Lys Gln Asp Lys Lys Tyr Leu Asn Asp Asn Phe Leu Lys 
    530                 535                 540                 


Asp Ala Ile Leu Pro Pro Asn Val Lys Val Thr Phe Gln Gln Ala Ile 
545                 550                 555                 560 


Leu Ile Phe Asn Lys Ile Ile Gln Lys Phe Ser Lys Asp Phe Glu Ile 
                565                 570                 575     


Asp Lys Val Val Ile Glu Leu Ala Arg Glu Met Thr Gln Asp Gln Glu 
            580                 585                 590         


Asn Asp Ala Leu Lys Gly Ile Ala Lys Ala Gln Lys Ser Lys Lys Ser 
        595                 600                 605             


Leu Val Glu Glu Arg Leu Glu Ala Asn Asn Ile Asp Lys Ser Val Phe 
    610                 615                 620                 


Asn Asp Lys Tyr Glu Lys Leu Ile Tyr Lys Ile Phe Leu Trp Ile Ser 
625                 630                 635                 640 


Gln Asp Phe Lys Asp Pro Tyr Thr Gly Ala Gln Ile Ser Thr Asn Glu 
                645                 650                 655     


Ile Val Asn Asn Lys Val Glu Ile Asp His Ile Ile Pro Tyr Ser Leu 
            660                 665                 670         


Cys Phe Asp Asp Ser Ser Ala Asn Lys Val Leu Val His Lys Gln Ser 
        675                 680                 685             


Asn Gln Glu Lys Ser Asn Ser Leu Pro Tyr Glu Tyr Ile Lys Gln Gly 
    690                 695                 700                 


His Ser Gly Trp Asn Trp Asp Glu Phe Thr Lys Tyr Val Lys Arg Val 
705                 710                 715                 720 


Phe Val Asn Asn Val Asp Ser Ile Leu Ser Lys Lys Glu Arg Leu Lys 
                725                 730                 735     


Lys Ser Glu Asn Leu Leu Thr Thr Ser Tyr Asp Gly Tyr Asp Lys Leu 
            740                 745                 750         


Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Leu 
        755                 760                 765             


Phe Arg Asp Gln Leu Asn Asn Tyr Ala Glu His His Leu Ile Asp Asn 
    770                 775                 780                 


Lys Lys Met Phe Lys Val Ile Ala Met Asn Gly Ala Val Thr Ser Phe 
785                 790                 795                 800 


Ile Arg Lys Asn Met Ser Tyr Asp Asn Lys Leu Arg Leu Lys Asp Arg 
                805                 810                 815     


Ser Asp Phe Ser His His Ala Tyr Asp Ala Ala Ile Ile Ala Leu Phe 
            820                 825                 830         


Ser Asn Lys Thr Lys Thr Leu Tyr Asn Leu Ile Asp Pro Ser Leu Asn 
        835                 840                 845             


Gly Ile Ile Ser Lys Arg Ser Glu Gly Tyr Trp Val Ile Glu Asp Arg 
    850                 855                 860                 


Tyr Thr Gly Glu Ile Lys Glu Leu Lys Lys Glu Asp Trp Thr Ser Ile 
865                 870                 875                 880 


Lys Asn Asn Val Gln Ala Arg Lys Ile Ala Lys Glu Ile Glu Glu Tyr 
                885                 890                 895     


Leu Ile Asp Leu Asp Asp Glu Val Phe Phe Ser Arg Lys Thr Lys Arg 
            900                 905                 910         


Lys Thr Asn Arg Gln Leu Tyr Asn Glu Thr Ile Tyr Gly Ile Ala Ala 
        915                 920                 925             


Lys Thr Asp Glu Asp Gly Ile Thr Asn Tyr Tyr Lys Lys Glu Lys Phe 
    930                 935                 940                 


Ser Ile Leu Asp Asp Lys Asp Ile Tyr Leu Arg Leu Leu Arg Glu Arg 
945                 950                 955                 960 


Glu Lys Phe Val Ile Asn Gln Ser Asn Pro Glu Val Ile Asp Gln Ile 
                965                 970                 975     


Ile Glu Ile Ile Glu Ser Tyr Gly Lys Glu Asn Asn Ile Pro Ser Arg 
            980                 985                 990         


Asp Glu Ala Ile Asn Ile Lys Tyr  Thr Lys Asn Lys Ile  Asn Tyr Asn 
        995                 1000                 1005             


Leu Tyr  Leu Lys Gln Tyr Met  Arg Ser Leu Thr Lys  Ser Leu Asp 
    1010                 1015                 1020             


Gln Phe  Ser Glu Glu Phe Ile  Asn Gln Met Ile Ala  Asn Lys Thr 
    1025                 1030                 1035             


Phe Val  Leu Tyr Asn Pro Thr  Lys Asn Thr Thr Arg  Lys Ile Lys 
    1040                 1045                 1050             


Phe Leu  Arg Leu Val Asn Asp  Val Lys Ile Asn Asp  Ile Arg Lys 
    1055                 1060                 1065             


Asn Gln  Val Ile Asn Lys Phe  Asn Gly Lys Asn Asn  Glu Pro Lys 
    1070                 1075                 1080             


Ala Phe  Tyr Glu Asn Ile Asn  Ser Leu Gly Ala Ile  Val Phe Lys 
    1085                 1090                 1095             


Asn Ser  Ala Asn Asn Phe Lys  Thr Leu Ser Ile Asn  Thr Gln Ile 
    1100                 1105                 1110             


Ala Ile  Phe Gly Asp Lys Asn  Trp Asp Ile Glu Asp  Phe Lys Thr 
    1115                 1120                 1125             


Tyr Asn  Met Glu Lys Ile Glu  Lys Tyr Lys Glu Ile  Tyr Gly Ile 
    1130                 1135                 1140             


Asp Lys  Thr Tyr Asn Phe His  Ser Phe Ile Phe Pro  Gly Thr Ile 
    1145                 1150                 1155             


Leu Leu  Asp Lys Gln Asn Lys  Glu Phe Tyr Tyr Ile  Ser Ser Ile 
    1160                 1165                 1170             


Gln Thr  Val Arg Asp Ile Ile  Glu Ile Lys Phe Leu  Asn Lys Ile 
    1175                 1180                 1185             


Glu Phe  Lys Asp Glu Asn Lys  Asn Pro Asp Thr Ser  Lys Thr Pro 
    1190                 1195                 1200             


Lys Arg  Leu Met Phe Gly Ile  Lys Ser Ile Met Asn  Asn Tyr Glu 
    1205                 1210                 1215             


Gln Val  Asp Ile Ser Pro Phe  Gly Ile Asn Lys Lys  Ile Phe Glu 
    1220                 1225                 1230             


<210> 326
<211> 1233
<212> PRT
<213> Mycoplasma canis


<220>
<223> Mycoplasma canis UF33

<400> 326
Met Glu Lys Lys Arg Lys Val Thr Leu Gly Phe Asp Leu Gly Ile Ala 
1               5                   10                  15      


Ser Val Gly Trp Ala Ile Val Asp Ser Glu Thr Asn Gln Val Tyr Lys 
            20                  25                  30          


Leu Gly Ser Arg Leu Phe Asp Ala Pro Asp Thr Asn Leu Glu Arg Arg 
        35                  40                  45              


Thr Gln Arg Gly Thr Arg Arg Leu Leu Arg Arg Arg Lys Tyr Arg Asn 
    50                  55                  60                  


Gln Lys Phe Tyr Asn Leu Val Lys Arg Thr Glu Val Phe Gly Leu Ser 
65                  70                  75                  80  


Ser Arg Glu Ala Ile Glu Asn Arg Phe Arg Glu Leu Ser Ile Lys Tyr 
                85                  90                  95      


Pro Asn Ile Ile Glu Leu Lys Thr Lys Ala Leu Ser Gln Glu Val Cys 
            100                 105                 110         


Pro Asp Glu Ile Ala Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 
        115                 120                 125             


Tyr Phe Tyr Asp Glu Lys Glu Thr Lys Glu Asp Phe Asp Gln Gln Thr 
    130                 135                 140                 


Val Glu Ser Met Pro Ser Tyr Lys Leu Asn Glu Phe Tyr Lys Lys Tyr 
145                 150                 155                 160 


Gly Tyr Phe Lys Gly Ala Leu Ser Gln Pro Thr Glu Ser Glu Met Lys 
                165                 170                 175     


Asp Asn Lys Asp Leu Lys Glu Ala Phe Phe Phe Asp Phe Ser Asn Lys 
            180                 185                 190         


Glu Trp Leu Lys Glu Ile Asn Tyr Phe Phe Asn Val Gln Lys Asn Ile 
        195                 200                 205             


Leu Ser Glu Thr Phe Ile Glu Glu Phe Lys Lys Ile Phe Ser Phe Thr 
    210                 215                 220                 


Arg Asp Ile Ser Lys Gly Pro Gly Ser Asp Asn Met Pro Ser Pro Tyr 
225                 230                 235                 240 


Gly Ile Phe Gly Glu Phe Gly Asp Asn Gly Gln Gly Gly Arg Tyr Glu 
                245                 250                 255     


His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Thr Asn Glu 
            260                 265                 270         


Gln Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Ile Phe Asn Phe Leu 
        275                 280                 285             


Asn Glu Leu Ala Asn Ile Arg Leu Tyr Ser Thr Asp Lys Lys Asn Ile 
    290                 295                 300                 


Gln Pro Leu Trp Lys Leu Ser Ser Val Asp Lys Leu Asn Ile Leu Leu 
305                 310                 315                 320 


Asn Leu Phe Asn Leu Pro Ile Ser Glu Lys Lys Lys Lys Leu Thr Ser 
                325                 330                 335     


Thr Asn Ile Asn Asp Ile Val Lys Lys Glu Ser Ile Lys Ser Ile Met 
            340                 345                 350         


Ile Ser Val Glu Asp Ile Asp Met Ile Lys Asp Glu Trp Ala Gly Lys 
        355                 360                 365             


Glu Pro Asn Val Tyr Gly Val Gly Leu Ser Gly Leu Asn Ile Glu Glu 
    370                 375                 380                 


Asn Ala Lys Glu Asn Lys Phe Lys Phe Gln Asp Leu Lys Ile Leu Asn 
385                 390                 395                 400 


Val Leu Ile Asn Leu Leu Asp Asn Val Gly Ile Lys Phe Glu Phe Lys 
                405                 410                 415     


Asp Arg Asn Asp Ile Ile Lys Asn Leu Glu Leu Leu Asp Asn Leu Tyr 
            420                 425                 430         


Leu Phe Leu Ile Tyr Gln Lys Glu Ser Asn Asn Lys Asp Ser Ser Ile 
        435                 440                 445             


Asp Leu Phe Ile Ala Lys Asn Lys Ser Leu Asn Ile Glu Asn Leu Lys 
    450                 455                 460                 


Leu Lys Leu Lys Glu Phe Leu Leu Gly Ala Gly Asn Glu Phe Glu Asn 
465                 470                 475                 480 


His Asn Ser Lys Ser His Ser Leu Ser Lys Lys Ala Ile Asp Ala Ile 
                485                 490                 495     


Leu Pro Lys Leu Leu Asp Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 
            500                 505                 510         


Lys Asn Tyr Asp Glu Glu Ile Lys Ser Gln Ile Glu Asp Asn Ser Ser 
        515                 520                 525             


Leu Met Ala Lys Gln Asp Lys Lys Tyr Leu Asn Asp Asn Phe Leu Lys 
    530                 535                 540                 


Asp Ala Ile Leu Pro Pro Asn Val Lys Val Thr Phe Gln Gln Ala Ile 
545                 550                 555                 560 


Leu Ile Phe Asn Lys Ile Ile Gln Lys Phe Ser Lys Asp Phe Glu Ile 
                565                 570                 575     


Asp Lys Val Val Ile Glu Leu Ala Arg Glu Met Thr Gln Asp Gln Glu 
            580                 585                 590         


Asn Asp Ala Leu Lys Gly Met Ala Lys Ala Gln Lys Ser Lys Lys Ser 
        595                 600                 605             


Leu Val Glu Glu Arg Leu Glu Ala Asn Asn Ile Asp Lys Ser Val Phe 
    610                 615                 620                 


Asn Asp Lys Tyr Glu Lys Leu Ile Tyr Lys Ile Phe Leu Trp Ile Ser 
625                 630                 635                 640 


Gln Asp Phe Lys Asp Pro Tyr Thr Gly Ala Gln Ile Ser Val Asn Glu 
                645                 650                 655     


Ile Val Asn Asn Lys Val Glu Ile Asp His Ile Ile Pro Tyr Ser Leu 
            660                 665                 670         


Cys Phe Asp Asp Ser Ser Ala Asn Lys Val Leu Val His Lys Gln Ser 
        675                 680                 685             


Asn Gln Glu Lys Ser Asn Ser Leu Pro Tyr Glu Tyr Ile Lys Gln Gly 
    690                 695                 700                 


His Ser Gly Trp Asn Trp Asp Glu Phe Thr Lys Tyr Val Lys Arg Val 
705                 710                 715                 720 


Phe Val Asn Asn Val Asp Ser Ile Leu Ser Lys Lys Glu Arg Leu Lys 
                725                 730                 735     


Lys Ser Glu Asn Leu Leu Thr Thr Ser Tyr Asp Gly Tyr Asp Lys Leu 
            740                 745                 750         


Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Leu 
        755                 760                 765             


Phe Arg Asp Gln Leu Asn Asn Tyr Ala Glu His His Leu Ile Asp Asn 
    770                 775                 780                 


Lys Lys Met Phe Lys Val Ile Ala Met Asn Gly Ala Val Thr Ser Phe 
785                 790                 795                 800 


Ile Arg Lys Asn Met Ser Tyr Asp Asn Lys Leu Arg Leu Lys Asp Arg 
                805                 810                 815     


Ser Asp Phe Ser His His Ala Tyr Asp Ala Ala Ile Ile Ala Leu Phe 
            820                 825                 830         


Ser Asn Lys Thr Lys Thr Leu Tyr Asn Leu Ile Asp Pro Ser Leu Asn 
        835                 840                 845             


Gly Ile Ile Ser Lys Arg Ser Glu Gly Tyr Trp Val Ile Glu Asp Arg 
    850                 855                 860                 


Tyr Thr Gly Glu Ile Lys Glu Leu Lys Lys Glu Asp Trp Thr Ser Ile 
865                 870                 875                 880 


Lys Asn Asn Val Gln Ala Arg Lys Ile Ala Lys Glu Ile Glu Glu Tyr 
                885                 890                 895     


Leu Ile Asp Leu Asp Asp Glu Val Phe Phe Ser Arg Lys Thr Lys Arg 
            900                 905                 910         


Lys Thr Asn Arg Gln Leu Tyr Asn Glu Thr Ile Tyr Gly Ile Ala Ala 
        915                 920                 925             


Lys Thr Asp Glu Asp Gly Ile Thr Asn Tyr Tyr Lys Lys Glu Lys Phe 
    930                 935                 940                 


Ser Ile Leu Asp Asp Lys Asp Ile Tyr Leu Arg Leu Leu Arg Glu Arg 
945                 950                 955                 960 


Glu Lys Phe Val Ile Asn Gln Ser Asn Pro Glu Val Ile Asp Gln Ile 
                965                 970                 975     


Ile Glu Ile Ile Glu Ser Tyr Gly Lys Glu Asn Asn Ile Pro Ser Arg 
            980                 985                 990         


Asp Glu Ala Ile Asn Ile Lys Tyr  Thr Lys Asn Lys Ile  Asn Tyr Asn 
        995                 1000                 1005             


Leu Tyr  Leu Lys Gln Tyr Met  Arg Ser Leu Thr Lys  Ser Leu Asp 
    1010                 1015                 1020             


Lys Phe  Ser Glu Glu Phe Ile  Asn Gln Met Ile Ala  Asn Lys Thr 
    1025                 1030                 1035             


Phe Val  Leu Tyr Asn Pro Thr  Lys Asn Thr Thr Arg  Lys Ile Lys 
    1040                 1045                 1050             


Phe Leu  Arg Leu Val Asn Asp  Val Lys Ile Asn Asp  Ile Arg Lys 
    1055                 1060                 1065             


Asn Gln  Val Ile Asn Lys Phe  Asn Gly Lys Asn Asn  Glu Pro Lys 
    1070                 1075                 1080             


Ala Phe  Tyr Glu Asn Ile Asn  Ser Leu Gly Ala Ile  Val Phe Lys 
    1085                 1090                 1095             


Asn Ser  Ala Asn Asn Phe Lys  Thr Leu Ser Ile Asn  Thr Gln Ile 
    1100                 1105                 1110             


Ala Ile  Phe Gly Asp Lys Asn  Trp Asp Ile Glu Asp  Phe Lys Thr 
    1115                 1120                 1125             


Tyr Asn  Met Glu Lys Ile Glu  Lys Tyr Lys Glu Ile  Tyr Gly Ile 
    1130                 1135                 1140             


Asp Lys  Thr Tyr Asn Phe His  Ser Phe Ile Phe Pro  Gly Thr Ile 
    1145                 1150                 1155             


Leu Leu  Asp Lys Gln Asn Lys  Glu Phe Tyr Tyr Ile  Ser Ser Ile 
    1160                 1165                 1170             


Gln Thr  Val Arg Asp Ile Ile  Glu Ile Lys Phe Leu  Asn Lys Ile 
    1175                 1180                 1185             


Glu Phe  Lys Asp Glu Asn Lys  Asn Gln Asp Thr Ser  Lys Thr Pro 
    1190                 1195                 1200             


Lys Arg  Leu Met Phe Gly Ile  Lys Ser Ile Met Asn  Asn Tyr Glu 
    1205                 1210                 1215             


Gln Val  Asp Ile Ser Pro Phe  Gly Ile Asn Lys Lys  Ile Phe Glu 
    1220                 1225                 1230             


<210> 327
<211> 1233
<212> PRT
<213> Mycoplasma canis


<220>
<223> Mycoplasma canis UFG1

<400> 327
Met Glu Lys Lys Arg Lys Val Thr Leu Gly Phe Asp Leu Gly Ile Ala 
1               5                   10                  15      


Ser Val Gly Trp Ala Ile Val Asp Ser Glu Thr Asn Gln Val Tyr Lys 
            20                  25                  30          


Leu Gly Ser Arg Leu Phe Asp Ala Pro Asp Thr Asn Leu Glu Arg Arg 
        35                  40                  45              


Thr Gln Arg Gly Thr Arg Arg Leu Leu Arg Arg Arg Lys Tyr Arg Asn 
    50                  55                  60                  


Gln Lys Phe Tyr Asn Leu Val Lys Arg Thr Glu Val Phe Gly Leu Ser 
65                  70                  75                  80  


Ser Arg Glu Ala Ile Glu Asn Arg Phe Arg Glu Leu Ser Ile Lys Tyr 
                85                  90                  95      


Pro Asn Ile Ile Glu Leu Lys Thr Lys Ala Leu Ser Gln Glu Val Cys 
            100                 105                 110         


Pro Asp Glu Ile Ala Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 
        115                 120                 125             


Tyr Phe Tyr Asp Glu Lys Glu Thr Lys Glu Asp Phe Asp Gln Gln Thr 
    130                 135                 140                 


Val Glu Ser Met Pro Ser Tyr Lys Leu Asn Glu Phe Tyr Lys Lys Tyr 
145                 150                 155                 160 


Gly Tyr Phe Lys Gly Ala Leu Ser Gln Pro Thr Glu Ser Glu Met Lys 
                165                 170                 175     


Asp Asn Lys Asp Leu Lys Glu Ala Phe Phe Phe Asp Phe Ser Asn Lys 
            180                 185                 190         


Glu Trp Leu Lys Glu Ile Asn Tyr Phe Phe Asn Val Gln Lys Asn Ile 
        195                 200                 205             


Leu Ser Glu Thr Phe Ile Glu Glu Phe Lys Lys Ile Phe Ser Phe Thr 
    210                 215                 220                 


Arg Asp Ile Ser Lys Gly Pro Gly Ser Asp Asn Met Pro Ser Pro Tyr 
225                 230                 235                 240 


Gly Ile Phe Gly Glu Phe Gly Asp Asn Gly Gln Gly Gly Arg Tyr Glu 
                245                 250                 255     


His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Thr Asn Glu 
            260                 265                 270         


Gln Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Ile Phe Asn Phe Leu 
        275                 280                 285             


Asn Glu Leu Ala Asn Ile Arg Leu Tyr Ser Thr Asp Lys Lys Asn Ile 
    290                 295                 300                 


Gln Pro Leu Trp Lys Leu Ser Ser Val Asp Lys Leu Asn Ile Leu Leu 
305                 310                 315                 320 


Asn Leu Phe Asn Leu Pro Ile Ser Glu Lys Lys Lys Lys Leu Thr Ser 
                325                 330                 335     


Thr Asn Ile Asn Asp Ile Val Lys Lys Glu Ser Ile Lys Ser Ile Met 
            340                 345                 350         


Leu Ser Val Glu Asp Ile Asp Met Ile Lys Tyr Glu Trp Ala Gly Lys 
        355                 360                 365             


Glu Pro Asn Val Tyr Gly Val Gly Leu Ser Gly Leu Asn Ile Glu Glu 
    370                 375                 380                 


Ser Ala Lys Glu Asn Lys Phe Lys Phe Gln Asp Leu Lys Ile Leu Asn 
385                 390                 395                 400 


Val Leu Ile Asn Leu Leu Asp Asn Val Gly Ile Lys Phe Glu Phe Lys 
                405                 410                 415     


Asp Arg Asn Asp Ile Ile Lys Asn Leu Glu Leu Leu Asp Asn Leu Tyr 
            420                 425                 430         


Leu Phe Leu Ile Tyr Gln Lys Glu Ser Asn Asn Lys Asp Ser Ser Ile 
        435                 440                 445             


Asp Leu Phe Ile Ala Lys Asn Lys Ser Leu Asn Ile Glu Asn Leu Lys 
    450                 455                 460                 


Leu Lys Leu Lys Glu Phe Leu Leu Gly Ala Gly Asn Glu Phe Glu Asn 
465                 470                 475                 480 


His Asn Ser Lys Thr His Ser Leu Ser Lys Lys Ala Ile Asp Ala Ile 
                485                 490                 495     


Leu Pro Lys Leu Leu Asp Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 
            500                 505                 510         


Lys Asn Tyr Asp Glu Glu Ile Lys Ser Gln Ile Glu Asp Asn Ser Ser 
        515                 520                 525             


Leu Met Ala Lys Gln Asp Lys Lys Tyr Leu Asn Asp Asn Phe Leu Lys 
    530                 535                 540                 


Asp Ala Ile Leu Pro Pro Asn Val Lys Val Thr Phe Gln Gln Ala Ile 
545                 550                 555                 560 


Leu Ile Phe Asn Lys Ile Ile Gln Lys Phe Ser Lys Asp Phe Glu Ile 
                565                 570                 575     


Asp Lys Val Val Ile Glu Leu Ala Arg Glu Met Thr Gln Asp Gln Glu 
            580                 585                 590         


Asn Asp Ala Leu Lys Gly Ile Ala Lys Ala Gln Lys Ser Lys Lys Ser 
        595                 600                 605             


Leu Val Glu Glu Arg Leu Glu Ala Asn Asn Ile Asp Lys Ser Val Phe 
    610                 615                 620                 


Asp Asp Lys Tyr Glu Lys Leu Ile Tyr Lys Ile Phe Leu Trp Ile Ser 
625                 630                 635                 640 


Gln Asp Phe Lys Asp Pro Tyr Thr Gly Ala Lys Ile Ser Ala Asn Glu 
                645                 650                 655     


Ile Val Asn Asn Lys Val Glu Ile Asp His Ile Ile Pro Tyr Ser Leu 
            660                 665                 670         


Cys Phe Asp Asp Ser Ser Ala Asn Lys Val Leu Val His Lys Gln Ser 
        675                 680                 685             


Asn Gln Glu Lys Ser Asn Ser Leu Pro Tyr Glu Tyr Ile Lys Gln Gly 
    690                 695                 700                 


His Ser Gly Trp Asn Trp Asp Glu Phe Thr Lys Tyr Val Lys Arg Val 
705                 710                 715                 720 


Phe Val Asn Asn Val Asp Ser Ile Leu Ser Lys Lys Glu Arg Leu Lys 
                725                 730                 735     


Lys Ser Glu Asn Leu Leu Thr Thr Ser Tyr Asp Gly Tyr Asp Lys Leu 
            740                 745                 750         


Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Leu 
        755                 760                 765             


Phe Arg Asp Gln Leu Asn Asn Tyr Ala Glu His His Leu Ile Asp Asn 
    770                 775                 780                 


Lys Lys Met Phe Lys Val Ile Ala Met Asn Gly Ala Val Thr Ser Phe 
785                 790                 795                 800 


Ile Arg Lys Asn Met Ser Tyr Asp Asn Lys Leu Arg Leu Lys Asp Arg 
                805                 810                 815     


Ser Asp Phe Ser His His Ala Tyr Asp Ala Ala Ile Ile Ala Leu Phe 
            820                 825                 830         


Ser Asn Lys Thr Lys Thr Leu Tyr Asn Leu Ile Asp Pro Ser Leu Asn 
        835                 840                 845             


Gly Ile Ile Ser Lys Arg Ser Glu Gly Tyr Trp Val Ile Glu Asp Arg 
    850                 855                 860                 


Tyr Thr Gly Glu Ile Lys Glu Leu Lys Lys Glu Asp Trp Thr Ser Ile 
865                 870                 875                 880 


Lys Asn Asn Val Gln Ala Arg Lys Ile Ala Lys Glu Ile Glu Glu Tyr 
                885                 890                 895     


Leu Ile Asp Leu Asp Asp Glu Val Phe Phe Ser Arg Lys Thr Lys Arg 
            900                 905                 910         


Lys Thr Asn Arg Gln Leu Tyr Asn Glu Thr Ile Tyr Gly Ile Ala Ala 
        915                 920                 925             


Lys Thr Asp Glu Asp Gly Ile Thr Asn Tyr Tyr Lys Lys Glu Lys Phe 
    930                 935                 940                 


Ser Ile Leu Asp Asp Lys Asp Ile Tyr Leu Arg Leu Leu Arg Glu Arg 
945                 950                 955                 960 


Glu Lys Phe Val Ile Asn Gln Ser Asn Pro Glu Val Ile Asp Gln Ile 
                965                 970                 975     


Ile Glu Ile Ile Glu Ser Tyr Gly Lys Glu Asn Asn Ile Pro Ser Arg 
            980                 985                 990         


Asp Glu Ala Ile Asn Ile Lys Tyr  Thr Lys Asn Lys Ile  Asn Tyr Asn 
        995                 1000                 1005             


Leu Tyr  Leu Lys Gln Tyr Met  Arg Ser Leu Thr Lys  Ser Leu Asp 
    1010                 1015                 1020             


Gln Phe  Ser Glu Glu Phe Ile  Asn Gln Met Ile Ala  Asn Lys Thr 
    1025                 1030                 1035             


Phe Val  Leu Tyr Asn Pro Thr  Lys Asn Thr Thr Arg  Lys Ile Lys 
    1040                 1045                 1050             


Phe Leu  Arg Leu Val Asn Asp  Val Lys Ile Asn Asp  Ile Arg Lys 
    1055                 1060                 1065             


Asn Gln  Val Ile Asn Lys Phe  Asn Gly Lys Asn Asn  Glu Pro Lys 
    1070                 1075                 1080             


Ala Phe  Tyr Glu Asn Ile Asn  Ser Leu Gly Ala Ile  Val Phe Lys 
    1085                 1090                 1095             


Asn Ser  Ala Asn Asn Phe Lys  Thr Leu Ser Ile Asn  Thr Gln Ile 
    1100                 1105                 1110             


Ala Ile  Phe Gly Asp Lys Asn  Trp Asp Ile Glu Asp  Phe Lys Thr 
    1115                 1120                 1125             


Tyr Asn  Met Glu Lys Ile Glu  Lys Tyr Lys Glu Ile  Tyr Gly Ile 
    1130                 1135                 1140             


Asp Lys  Thr Tyr Asn Phe His  Ser Phe Ile Phe Pro  Gly Thr Ile 
    1145                 1150                 1155             


Leu Leu  Asp Lys Gln Asn Lys  Glu Phe Tyr Tyr Ile  Ser Ser Ile 
    1160                 1165                 1170             


Gln Thr  Val Arg Asp Ile Ile  Glu Ile Lys Phe Leu  Asn Lys Ile 
    1175                 1180                 1185             


Glu Phe  Lys Asp Glu Asn Lys  Asn Gln Asp Thr Ser  Lys Thr Pro 
    1190                 1195                 1200             


Lys Arg  Leu Met Phe Gly Ile  Lys Ser Ile Met Asn  Asn Tyr Glu 
    1205                 1210                 1215             


Gln Val  Asp Ile Ser Pro Phe  Gly Ile Asn Lys Lys  Ile Phe Glu 
    1220                 1225                 1230             


<210> 328
<211> 1233
<212> PRT
<213> Mycoplasma canis


<220>
<223> Mycoplasma canis UFG4

<400> 328
Met Glu Lys Lys Arg Lys Val Thr Leu Gly Phe Asp Leu Gly Ile Ala 
1               5                   10                  15      


Ser Val Gly Trp Ala Ile Val Asp Ser Glu Thr Asn Gln Val Tyr Lys 
            20                  25                  30          


Leu Gly Ser Arg Leu Phe Asp Ala Pro Asp Thr Asn Leu Glu Arg Arg 
        35                  40                  45              


Thr Gln Arg Gly Thr Arg Arg Leu Leu Arg Arg Arg Lys Tyr Arg Asn 
    50                  55                  60                  


Gln Lys Phe Tyr Asn Leu Val Lys Arg Thr Glu Val Phe Gly Leu Ser 
65                  70                  75                  80  


Ser Arg Glu Ala Ile Glu Asn Arg Phe Arg Glu Leu Ser Ile Lys Tyr 
                85                  90                  95      


Pro Asn Ile Ile Glu Leu Lys Thr Lys Ala Leu Ser Gln Glu Val Cys 
            100                 105                 110         


Pro Asp Glu Ile Ala Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 
        115                 120                 125             


Tyr Phe Tyr Asp Glu Lys Glu Thr Lys Glu Asp Phe Asp Gln Gln Thr 
    130                 135                 140                 


Ile Glu Ser Met Pro Ser Tyr Lys Leu Asn Glu Phe Tyr Lys Lys Tyr 
145                 150                 155                 160 


Gly Tyr Phe Lys Gly Ala Leu Ser Gln Pro Thr Glu Ser Glu Met Lys 
                165                 170                 175     


Asp Asn Lys Asp Leu Lys Glu Ala Phe Phe Phe Asp Phe Ser Asn Lys 
            180                 185                 190         


Glu Trp Leu Lys Glu Ile Asn Tyr Phe Phe Asn Val Gln Lys Asn Ile 
        195                 200                 205             


Leu Ser Glu Thr Phe Ile Glu Glu Phe Lys Lys Ile Phe Ser Phe Thr 
    210                 215                 220                 


Arg Asp Ile Ser Lys Gly Pro Gly Ser Asp Asn Met Pro Ser Pro Tyr 
225                 230                 235                 240 


Gly Ile Phe Gly Glu Phe Gly Asp Asn Gly Gln Gly Gly Arg Tyr Glu 
                245                 250                 255     


His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Thr Asn Glu 
            260                 265                 270         


Gln Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Ile Phe Asn Phe Leu 
        275                 280                 285             


Asn Glu Leu Ala Asn Ile Arg Leu Tyr Ser Thr Asp Lys Lys Asn Ile 
    290                 295                 300                 


Gln Pro Leu Trp Lys Leu Ser Ser Ile Asp Lys Leu Asn Ile Leu Leu 
305                 310                 315                 320 


Asn Leu Phe Asn Leu Pro Ile Ser Glu Lys Lys Lys Lys Leu Thr Ser 
                325                 330                 335     


Ala Asn Ile Asn Asp Ile Val Lys Lys Glu Ser Thr Lys Ser Ile Met 
            340                 345                 350         


Leu Ser Val Glu Asp Ile Asp Met Ile Lys Asp Glu Trp Ala Gly Lys 
        355                 360                 365             


Glu Pro Asn Val Tyr Gly Val Gly Leu Ser Gly Leu Asn Ile Glu Glu 
    370                 375                 380                 


Ser Ala Lys Glu Asn Lys Phe Lys Phe Gln Asp Leu Lys Ile Leu Asn 
385                 390                 395                 400 


Val Leu Ile Asn Leu Leu Asp Asn Val Gly Ile Lys Phe Glu Phe Lys 
                405                 410                 415     


Asp Arg Asn Asp Ile Ile Lys Asn Leu Glu Leu Leu Asp Asn Leu Tyr 
            420                 425                 430         


Leu Phe Leu Ile Tyr Gln Lys Glu Ser Asn Asn Lys Asp Ser Ser Ile 
        435                 440                 445             


Asp Leu Phe Ile Ala Lys Asn Glu Ser Leu Asn Ile Glu Asn Leu Lys 
    450                 455                 460                 


Leu Lys Leu Lys Glu Phe Leu Leu Gly Ala Gly Asn Glu Phe Glu Asn 
465                 470                 475                 480 


His Asn Ser Lys Thr His Ser Leu Ser Lys Lys Ala Ile Asp Ala Ile 
                485                 490                 495     


Leu Pro Lys Leu Leu Asp Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 
            500                 505                 510         


Lys Asn Tyr Asp Glu Glu Ile Lys Ser Gln Ile Glu Asp Asn Ser Phe 
        515                 520                 525             


Leu Met Ala Lys Gln Asp Lys Lys Tyr Leu Asn Asp Asn Phe Leu Lys 
    530                 535                 540                 


Asp Ala Ile Leu Pro Pro Asn Val Lys Val Thr Phe Gln Gln Ala Ile 
545                 550                 555                 560 


Leu Ile Phe Asn Lys Ile Ile Gln Lys Phe Ser Lys Asp Phe Glu Ile 
                565                 570                 575     


Asp Lys Val Val Ile Glu Leu Ala Arg Glu Met Thr Gln Asp Gln Glu 
            580                 585                 590         


Asn Asp Ala Leu Lys Gly Ile Ala Lys Ala Gln Lys Ser Lys Lys Ser 
        595                 600                 605             


Leu Val Glu Glu Arg Leu Glu Ala Asn Asn Ile Asp Lys Ser Val Phe 
    610                 615                 620                 


Asn Glu Lys Tyr Glu Lys Leu Ile Tyr Lys Ile Phe Leu Trp Ile Ser 
625                 630                 635                 640 


Gln Asp Phe Lys Asp Pro Tyr Thr Gly Ala Lys Ile Ser Ala Asn Glu 
                645                 650                 655     


Ile Val Asp Asn Lys Val Glu Ile Asp His Ile Ile Pro Tyr Ser Leu 
            660                 665                 670         


Cys Phe Asp Asp Ser Ser Ala Asn Lys Val Leu Val His Lys Gln Ser 
        675                 680                 685             


Asn Gln Glu Lys Ser Asn Ser Leu Pro Tyr Glu Tyr Ile Lys Gln Gly 
    690                 695                 700                 


His Ser Gly Trp Asn Trp Asp Glu Phe Thr Lys Tyr Val Lys Arg Val 
705                 710                 715                 720 


Phe Val Asn Asn Val Asp Ser Ile Leu Ser Lys Lys Glu Arg Leu Lys 
                725                 730                 735     


Lys Ser Glu Asn Leu Leu Thr Thr Ser Tyr Asp Gly Tyr Asp Lys Leu 
            740                 745                 750         


Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Leu 
        755                 760                 765             


Phe Arg Asp Gln Leu Asn Asn Tyr Ala Glu His His Leu Ile Asp Asp 
    770                 775                 780                 


Lys Lys Met Phe Lys Val Ile Ala Met Asn Gly Ala Val Thr Ser Phe 
785                 790                 795                 800 


Ile Arg Lys Asn Met Ser Tyr Asp Asn Lys Leu Arg Leu Lys Asn Arg 
                805                 810                 815     


Asn Asp Phe Ser His His Ala Tyr Asp Ala Ala Ile Ile Ala Leu Phe 
            820                 825                 830         


Ser Asn Lys Thr Lys Thr Leu Tyr Asn Leu Ile Asp Pro Ser Leu Asn 
        835                 840                 845             


Gly Ile Ile Ser Lys Arg Ser Glu Gly Tyr Trp Val Ile Glu Asp Arg 
    850                 855                 860                 


Tyr Thr Gly Glu Ile Lys Glu Leu Lys Lys Glu Asp Trp Thr Ser Ile 
865                 870                 875                 880 


Lys Asn Asn Val Gln Ala Arg Lys Ile Ala Lys Glu Ile Glu Glu Tyr 
                885                 890                 895     


Leu Ile Asp Leu Asp Asp Glu Val Phe Phe Ser Arg Lys Thr Lys Arg 
            900                 905                 910         


Lys Thr Asn Arg Gln Leu Tyr Asn Glu Thr Ile Tyr Gly Ile Ala Ala 
        915                 920                 925             


Lys Thr Asp Glu Asp Gly Ile Thr Asn Tyr Tyr Lys Lys Glu Lys Leu 
    930                 935                 940                 


Ser Ile Leu Asp Asp Lys Asp Ile Tyr Leu Arg Leu Leu Arg Glu Arg 
945                 950                 955                 960 


Glu Lys Phe Val Ile Asn Gln Ser Asn Pro Glu Val Ile Asp Gln Ile 
                965                 970                 975     


Ile Glu Ile Ile Glu Ser Tyr Gly Lys Glu Asn Asn Ile Pro Ser Arg 
            980                 985                 990         


Asp Glu Ala Ile Asn Ile Lys Tyr  Thr Lys Asn Lys Ile  Asn Tyr Asn 
        995                 1000                 1005             


Leu Tyr  Leu Lys Gln Tyr Met  Arg Ser Leu Thr Lys  Ser Leu Asp 
    1010                 1015                 1020             


Gln Phe  Ser Glu Glu Phe Ile  Asn Gln Met Ile Ala  Asn Lys Thr 
    1025                 1030                 1035             


Phe Val  Leu Tyr Asn Pro Thr  Lys Asn Thr Thr Arg  Lys Ile Lys 
    1040                 1045                 1050             


Phe Leu  Arg Leu Val Asn Asp  Val Lys Ile Asn Asp  Ile Arg Lys 
    1055                 1060                 1065             


Asn Gln  Val Ile Asn Lys Phe  Asn Gly Lys Asn Asn  Glu Pro Lys 
    1070                 1075                 1080             


Ala Phe  Tyr Glu Asn Ile Asn  Ser Leu Gly Ala Ile  Val Phe Lys 
    1085                 1090                 1095             


Asn Ser  Ala Asn Asn Phe Lys  Thr Leu Ser Ile Asn  Thr Gln Ile 
    1100                 1105                 1110             


Ala Ile  Phe Gly Asp Lys Asn  Trp Asp Ile Glu Asp  Phe Lys Thr 
    1115                 1120                 1125             


Tyr Asn  Met Glu Lys Ile Glu  Lys Tyr Lys Glu Ile  Tyr Gly Ile 
    1130                 1135                 1140             


Asp Lys  Thr Tyr Asn Phe His  Ser Phe Ile Phe Pro  Gly Thr Ile 
    1145                 1150                 1155             


Leu Leu  Asp Lys Gln Asn Lys  Glu Phe Tyr Tyr Ile  Ser Ser Ile 
    1160                 1165                 1170             


Gln Thr  Val Arg Asp Ile Ile  Glu Ile Lys Phe Leu  Asn Lys Ile 
    1175                 1180                 1185             


Glu Phe  Lys Asp Glu Asn Lys  Asn Gln Asp Thr Ser  Lys Thr Pro 
    1190                 1195                 1200             


Lys Arg  Leu Met Phe Gly Ile  Lys Ser Ile Met Asn  Asn Tyr Glu 
    1205                 1210                 1215             


Gln Val  Asp Ile Ser Pro Phe  Gly Ile Asn Lys Lys  Ile Phe Glu 
    1220                 1225                 1230             


<210> 329
<211> 1239
<212> PRT
<213> Mycoplasma cynos

<400> 329
Met Glu Glu Lys Arg Lys Val Thr Leu Gly Phe Asp Leu Gly Val Ala 
1               5                   10                  15      


Ser Val Gly Trp Ala Ile Val Asp Ser Glu Thr Asn Glu Val Tyr Lys 
            20                  25                  30          


Leu Gly Ser Arg Leu Phe Asp Ile Pro Asp Thr Asn Ile Asp Arg Arg 
        35                  40                  45              


Ala Lys Arg Gly Ser Arg Arg Leu Val Arg Arg Arg Ser Tyr Arg Asn 
    50                  55                  60                  


Gln Lys Phe Tyr Asn Leu Ile Lys Arg Thr Lys Thr Phe Gly Phe Leu 
65                  70                  75                  80  


Asp Lys Glu Ala Ile Glu Lys Glu Phe Val Leu Leu Ser Ile Lys Tyr 
                85                  90                  95      


Pro Asn Ile Ile Glu Leu Lys Val Lys Gly Leu Gln Glu Glu Val Ser 
            100                 105                 110         


Lys Ser Glu Ala Val Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 
        115                 120                 125             


Tyr Phe Tyr Asp Asp Lys Glu Glu Lys Asp Asp Leu Glu Asn Pro Ser 
    130                 135                 140                 


Ile Glu Ser Met Pro Ser Tyr Lys Leu Tyr Glu Phe Tyr Lys Glu Tyr 
145                 150                 155                 160 


Gly Tyr Phe Lys Gly Ala Leu Ser Ser Pro Thr Glu Ser Glu Lys Asn 
                165                 170                 175     


Lys Asp Ser Asp Leu Glu Lys Ala Ile Phe Phe Asn Phe Ser Asn Lys 
            180                 185                 190         


Glu Trp Thr Lys Glu Ile Asn His Phe Phe Lys Ile Gln Lys Asn Ile 
        195                 200                 205             


Phe Ser Glu Asp Phe Lys Ala Lys Phe Met Glu Phe Phe Ser Phe Ile 
    210                 215                 220                 


Arg Asp Ile Ser Lys Gly Pro Gly Ser Glu Asn Met Pro Ser Gln Tyr 
225                 230                 235                 240 


Ser Ile Phe Gly Lys Tyr Gly Asp Asp Gly Met Gly Gly Lys Tyr Gln 
                245                 250                 255     


His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Lys Asp Lys 
            260                 265                 270         


Val Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Phe Phe Asn Leu Leu 
        275                 280                 285             


Asn Glu Leu Ser Asn Ile Arg Leu Tyr Ser Val Asp Lys Arg Glu Lys 
    290                 295                 300                 


Ser Val Leu Trp Arg Leu Ser Ser Lys Asp Lys Ile Asn Ile Ile Leu 
305                 310                 315                 320 


Asn Ile Leu Gln Ile Ile Leu Phe Lys Asn Asp Gly Lys Ile Ser Asn 
                325                 330                 335     


Leu Asp Ile Asn Lys Ile Val Lys Asn Glu Ser Ile Lys Ser Ile Ile 
            340                 345                 350         


Leu Asn Glu Ile Asp Leu Asp Leu Ile Lys Asp Met Trp Phe Glu Lys 
        355                 360                 365             


Glu Pro Asn Val Tyr Gly Ile Gly Leu Ser Gly Leu Asn Ile Glu Glu 
    370                 375                 380                 


Asn Lys Lys Glu Asn Arg Phe Lys Phe Gln Asp Leu Lys Ile Phe Ser 
385                 390                 395                 400 


Val Phe Ile Asp Leu Leu Lys Lys Ser Asn Ile Asn Ile Glu Phe Asn 
                405                 410                 415     


Asn Glu Lys Asp Ile Ile His Asn Leu Lys Leu Leu Asp Glu Leu Tyr 
            420                 425                 430         


Phe Phe Leu Ile Thr Gln Lys Tyr Ser Arg Asp Lys Tyr Gly Ser Ile 
        435                 440                 445             


Lys Lys Phe Ile Leu Asn Asn Lys Ser Phe Asn Ile Asp Asn Leu Asp 
    450                 455                 460                 


Glu Lys Leu Asn Ile Phe Leu Ser Ile Ser Asp Asp Glu Phe Asp Asn 
465                 470                 475                 480 


His Asn Ser Lys Thr His Ser Leu Ser Lys Glu Ala Ile Tyr Phe Ile 
                485                 490                 495     


Phe Pro Lys Leu Leu His Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 
            500                 505                 510         


Lys Asn Tyr Asp Ile Asp Val Arg Glu Glu Ile Ser Lys His Ser Phe 
        515                 520                 525             


Gly Ile Lys Lys Gln Asp Lys Lys Tyr Leu Asp Asp Ala Phe Leu Asp 
    530                 535                 540                 


Asp Ala Ile Leu Pro Pro Ser Val Lys Val Thr Ile Lys Gln Ser Ile 
545                 550                 555                 560 


Leu Ile Phe Asn Lys Ile Ile Lys Lys Phe Ser Asn Lys Phe Gln Ile 
                565                 570                 575     


Asp Asn Val Val Ile Glu Leu Ala Arg Glu Met Thr Gln Glu Lys Glu 
            580                 585                 590         


Met Asp Ala Gln Lys Ser Leu Asn Arg Leu Lys Lys Ser Arg Lys Lys 
        595                 600                 605             


Ile Ile Glu Glu Arg Leu Asn Ala Asn Asn Ile Asp Ser Lys Met Phe 
    610                 615                 620                 


Arg Asp Lys Thr Gly Glu Ile Ser Pro Asn Tyr Ile Tyr Lys Ile Tyr 
625                 630                 635                 640 


Leu Trp Ile Ser Gln Asn Phe Lys Asp Pro Tyr Thr Gly Glu Asn Ile 
                645                 650                 655     


Ser Ala Asn Asp Ile Leu Lys Asn Asn Val Glu Ile Asp His Ile Ile 
            660                 665                 670         


Pro Tyr Ser Leu Cys Phe Asp Asp Ser Ser Ser Asn Lys Val Leu Val 
        675                 680                 685             


Phe Lys His Ser Asn Gln Ser Lys Gly Asn Phe Leu Pro Phe Asp Met 
    690                 695                 700                 


Ile Ser Thr Phe Ser Glu Asn Ser Val Trp Asn Trp Lys Glu Tyr Thr 
705                 710                 715                 720 


Gln Tyr Val Glu Lys Thr Phe Lys Thr Asn Leu Glu Ser Ile Leu Asp 
                725                 730                 735     


Lys Lys Glu Arg Val Lys Lys Ala Asp Asn Leu Leu Thr Ser Ser Tyr 
            740                 745                 750         


Asp Gly Tyr Asp Lys Leu Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr 
        755                 760                 765             


Arg Tyr Ala Thr Ile Leu Phe Arg Asp Gln Leu Ile Asn Tyr Ser Glu 
    770                 775                 780                 


Asn His Leu Ile Asp Ser Lys Lys Met Phe Lys Val Ile Ala Met Asn 
785                 790                 795                 800 


Gly Gly Val Thr Ser Phe Ile Arg Lys Asn Met Ser Phe Asp Ser Gly 
                805                 810                 815     


Leu Lys Val Lys Asp Arg Ser Ile Phe Ser His His Ala Tyr Asp Ala 
            820                 825                 830         


Ala Ile Ile Ala Leu Phe Ser Asn Lys Thr Lys Ile Leu Tyr Asn Leu 
        835                 840                 845             


Ile Asn Pro Ser Leu Asp Gly Ile Ile Ser Lys Arg Ser Glu Gly Tyr 
    850                 855                 860                 


Trp Val Leu Glu Asp Arg Leu Thr Gly Glu Ile Arg Lys Leu Asn Tyr 
865                 870                 875                 880 


Asn Asp Trp Gln Ser Ile Lys Asn Asn Val Glu Val Lys Lys Ile Ala 
                885                 890                 895     


Arg Glu Ile Glu Ser His Leu Ser Asn Leu Asp Asn Val Val Met Phe 
            900                 905                 910         


Ser Arg Lys Ser Lys Arg Lys Thr Asn Lys Glu Leu Tyr Asn Glu Thr 
        915                 920                 925             


Leu Tyr Gly Ile Ala Thr Arg Ile Asp Glu Asn Gly Ile Lys Asn Tyr 
    930                 935                 940                 


Tyr Lys Lys Glu Lys Phe Asn Ile Leu Glu Asp Glu Asn Ile Tyr Leu 
945                 950                 955                 960 


Arg Leu Leu Asn Glu Arg Glu Asn Phe Ile Ile Asn Arg Ser Asn Pro 
                965                 970                 975     


Glu Val Ile Asp Ala Ile Ile Glu Ile Phe Glu Thr Ile Asp Lys Asn 
            980                 985                 990         


Lys Ile Pro Ala Arg Asp Val Ala  Lys Asn Ile Lys Tyr  Thr Asp Asn 
        995                 1000                 1005             


Lys Ile  Lys Tyr Asn Leu Tyr  Leu Lys Asp Tyr Met  Arg Lys Leu 
    1010                 1015                 1020             


Val Asp  Glu Phe Pro Asp Lys  Phe Arg Lys Asp Phe  Ile Glu Gln 
    1025                 1030                 1035             


Met Ile  Ala Lys Lys Ile Phe  Ile Leu Phe Asn Pro  Ile Lys Asn 
    1040                 1045                 1050             


Thr Thr  Arg Lys Ile Lys Ser  Leu Arg Ser Ile Asn  Asn Asn Lys 
    1055                 1060                 1065             


Ile Glu  Asp Ile Arg Lys Lys  Gln Val Leu Glu Lys  Phe Asn Thr 
    1070                 1075                 1080             


Ala Lys  Asn Glu Pro Arg Ser  Phe Tyr Glu Ser Leu  Asn Ser Leu 
    1085                 1090                 1095             


Gly Ala  Ile Ile Phe Lys Asn  Asn Leu Asn Ile Tyr  Lys Lys Met 
    1100                 1105                 1110             


Ser Ile  Ser Ser Gln Ile Ala  Thr Phe Gly Asp Lys  Asn Trp Lys 
    1115                 1120                 1125             


Ile Asp  Asp Ile Asn Thr Tyr  Asn Lys Glu Lys Leu  Asn Lys Tyr 
    1130                 1135                 1140             


Lys Glu  Ile Tyr Gly Ile Asp  Glu Thr Tyr Asp Phe  Tyr Ser Phe 
    1145                 1150                 1155             


Ile Phe  Pro Gly Thr Ile Leu  Leu Asp Glu Lys Asn  Lys Glu Phe 
    1160                 1165                 1170             


Leu Tyr  Ile Ser Ser Ile Gln  Thr Leu Lys Asp Lys  Ile Glu Leu 
    1175                 1180                 1185             


Lys Phe  Leu Asp Arg Ile Glu  Phe Glu Lys Lys Asn  Val Asn Ser 
    1190                 1195                 1200             


Asn Leu  Lys Pro Lys Ile Lys  Arg Glu Ile Ile Ser  Thr Lys Lys 
    1205                 1210                 1215             


Leu Met  Ser Asp Tyr Lys Ile  Ile Lys Ile Ser Pro  Leu Gly Ile 
    1220                 1225                 1230             


Asn Lys  Lys Ile Phe Glu 
    1235                 


<210> 330
<211> 1269
<212> PRT
<213> Mycoplasma gallisepticum

<400> 330
Met Asn Asn Ser Ile Lys Ser Lys Pro Glu Val Thr Ile Gly Leu Asp 
1               5                   10                  15      


Leu Gly Val Gly Ser Val Gly Trp Ala Ile Val Asp Asn Glu Thr Asn 
            20                  25                  30          


Ile Ile His His Leu Gly Ser Arg Leu Phe Ser Gln Ala Lys Thr Ala 
        35                  40                  45              


Glu Asp Arg Arg Ser Phe Arg Gly Ala Arg Arg Leu Ile Arg Arg Arg 
    50                  55                  60                  


Lys Tyr Lys Leu Lys Arg Phe Ile Asn Leu Ile Trp Lys Tyr Asn Ser 
65                  70                  75                  80  


Tyr Phe Gly Phe Lys Asn Lys Glu Asp Ile Leu Asn Asn Tyr Gln Glu 
                85                  90                  95      


Gln Gln Lys Leu His Asn Thr Val Leu Asn Leu Lys Leu Glu Ala Leu 
            100                 105                 110         


Asn Ala Lys Ile Asp Pro Lys Ala Leu Ser Trp Ile Leu His Asp Tyr 
        115                 120                 125             


Leu Lys Asn Arg Gly His Phe Tyr Glu Asp Asn Arg Asp Phe Asn Val 
    130                 135                 140                 


Tyr Pro Thr Glu Glu Leu Ala Asn Tyr Phe Gly Glu Tyr Gly Tyr Tyr 
145                 150                 155                 160 


Lys Gly Ile Ile Asp Ser Lys Glu Asp Asn Asp Asp Lys Leu Glu Glu 
                165                 170                 175     


Gly Leu Thr Lys Tyr Lys Phe Ser Asn Gln His Trp Leu Glu Glu Ile 
            180                 185                 190         


Lys Lys Val Leu Ser Asn Gln Thr Gly Leu Pro Glu Lys Phe Lys Glu 
        195                 200                 205             


Glu Tyr Glu Ser Leu Phe Ser Tyr Val Arg Asn Tyr Ser Glu Gly Pro 
    210                 215                 220                 


Gly Ser Ile Asn Ser Val Ser Pro Tyr Gly Ile Tyr His Leu Asp Glu 
225                 230                 235                 240 


Lys Glu Gly Lys Val Val Gln Lys Tyr Asn Asn Ile Trp Asp Lys Thr 
                245                 250                 255     


Ile Gly Lys Cys Ser Ile Phe Pro Asp Glu Tyr Arg Ala Pro Lys Asn 
            260                 265                 270         


Ser Pro Ile Ala Met Ile Phe Asn Glu Ile Asn Glu Leu Ser Thr Ile 
        275                 280                 285             


Arg Ser Tyr Ser Ile Tyr Leu Thr Gly Trp Phe Ile Asn Gln Glu Phe 
    290                 295                 300                 


Lys Lys Ala Tyr Leu Asn Lys Leu Leu Asp Leu Leu Ile Lys Thr Asn 
305                 310                 315                 320 


Ser Glu Lys Pro Ile Asp Ala Arg Gln Phe Lys Lys Leu Arg Glu Glu 
                325                 330                 335     


Thr Ile Ala Glu Ser Ile Gly Lys Glu Thr Leu Lys Asp Val Glu Arg 
            340                 345                 350         


Glu Glu Lys Leu Glu Lys Glu Asp His Lys Trp Lys Leu Lys Gly Leu 
        355                 360                 365             


Lys Leu Asn Thr Asn Gly Lys Ile Gln Tyr Asn Asp Leu Ser Ser Leu 
    370                 375                 380                 


Ala Lys Phe Val His Lys Leu Lys Gln His Leu Lys Leu Asp Phe Leu 
385                 390                 395                 400 


Leu Glu Asp Gln Tyr Thr Thr Leu Asp Lys Ile Asn Phe Leu Gln Ser 
                405                 410                 415     


Leu Phe Val Tyr Leu Gly Lys His Leu Arg Tyr Ser Asn Arg Val Asp 
            420                 425                 430         


Ser Ala Asn Leu Lys Glu Phe Ser Asp Ser Asn Lys Leu Phe Glu Arg 
        435                 440                 445             


Val Leu Gln Glu Gln Lys Asp Asp Leu Phe Lys Leu Phe Glu Gln Thr 
    450                 455                 460                 


Asp Lys Asp Asp Glu Lys Ile Leu Ala Gln Thr His Ser Leu Ser Thr 
465                 470                 475                 480 


Lys Ala Met Leu Leu Ala Ile Thr Arg Met Thr Asn Leu Asp Asn Asp 
                485                 490                 495     


Glu Asp Asn Gln Lys Asn Asn Asp Lys Gly Trp Asn Phe Glu Ala Ile 
            500                 505                 510         


Lys Asn Phe Asp Gln Lys Phe Ile Asp Ile Thr Lys Lys Asn Asn Asn 
        515                 520                 525             


Leu Ser Leu Lys Gln Asp Lys Arg Tyr Leu Asp Asp Arg Phe Ile Asn 
    530                 535                 540                 


Asp Ala Ile Leu Ser Pro Gly Val Lys Arg Ile Leu Arg Glu Ala Thr 
545                 550                 555                 560 


Lys Val Phe Asn Ala Ile Leu Lys Gln Phe Ser Glu Glu Tyr Asp Val 
                565                 570                 575     


Thr Lys Val Val Ile Glu Leu Ala Arg Glu Leu Ser Glu Glu Lys Glu 
            580                 585                 590         


Leu Glu Asn Thr Lys Asn Tyr Glu Lys Leu Ile Lys Lys Asn Ser Asp 
        595                 600                 605             


Lys Ile Ser Glu Arg Leu Glu Ala Leu Asp Ile Ala Glu Asp Lys Ile 
    610                 615                 620                 


Glu Asp Ile Leu Lys Ser Pro Thr Lys Ser Tyr Lys Val Leu Leu Trp 
625                 630                 635                 640 


Leu Gln Gln Asp His Ile Asp Pro Tyr Ser Gln Lys Glu Ile Ala Phe 
                645                 650                 655     


Glu Asp Ile Leu Thr Lys Thr Glu Lys Thr Glu Ile Asp His Ile Ile 
            660                 665                 670         


Pro Tyr Ser Ile Ser Phe Asp Asp Ser Ser Ser Asn Lys Leu Leu Val 
        675                 680                 685             


Leu Ala Glu Ser Asn Gln Ala Lys Ser Asn Gln Thr Pro Tyr Glu Phe 
    690                 695                 700                 


Ile Thr Ser Gly Asn Ala Gly Ile Lys Trp Glu Asp Tyr Glu Ala Tyr 
705                 710                 715                 720 


Cys Arg Lys Phe Lys Asp Gly Asp Thr Ser Leu Leu Asp Ser Thr Gln 
                725                 730                 735     


Arg Ser Lys Lys Phe Ala Lys Met Met Lys Thr Asp Thr Ser Ser Lys 
            740                 745                 750         


Tyr Asp Ile Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala 
        755                 760                 765             


Thr Ile Val Phe Arg Asp Ala Leu Lys Asp Tyr Ala Asn Asn His Leu 
    770                 775                 780                 


Val Glu Asp Lys Pro Met Phe Lys Val Val Cys Ile Asn Gly Gly Val 
785                 790                 795                 800 


Thr Ser Phe Leu Arg Lys Asn Phe Asp Lys Ser Trp Tyr Ala Lys Lys 
                805                 810                 815     


Asp Arg Asp Lys Asn Ile His His Ala Val Asp Ala Ser Ile Ile Ser 
            820                 825                 830         


Ile Phe Ser Asn Glu Thr Lys Thr Leu Phe Asn Gln Leu Thr Gln Phe 
        835                 840                 845             


Ala Asp Tyr Lys Leu Phe Lys Asn Thr Asp Gly Ser Trp Lys Lys Ile 
    850                 855                 860                 


Asp Pro Lys Thr Gly Val Val Thr Glu Val Thr Asp Glu Asn Trp Lys 
865                 870                 875                 880 


Gln Ile Arg Val Arg Asn Gln Val Ser Glu Ile Ala Lys Val Ile Asn 
                885                 890                 895     


Lys Cys Ile Gln Asp Ser Asn Ile Glu Arg Lys Ala Arg Tyr Ser Arg 
            900                 905                 910         


Lys Ile Glu Asn Lys Thr Asn Ile Ser Leu Phe Asn Asp Thr Val Tyr 
        915                 920                 925             


Ser Ala Lys Lys Val Gly Tyr Glu Asp Gln Ile Lys Arg Lys Asn Leu 
    930                 935                 940                 


Lys Thr Leu Asp Ile His Glu Ser Ala Glu Glu Asn Lys Asn Ser Lys 
945                 950                 955                 960 


Val Lys Lys Gln Phe Val Tyr Arg Lys Leu Val Asn Val Ser Leu Leu 
                965                 970                 975     


Asn Asn Asp Lys Leu Ala Asp Leu Phe Ala Glu Lys Glu Asp Ile Leu 
            980                 985                 990         


Met Tyr Arg Ala Asn Pro Trp Val  Ile Asn Leu Ala Glu  Gln Ile Phe 
        995                 1000                 1005             


Asn Glu  Tyr Thr Glu Asn Lys  Lys Ile Lys Ser Gln  Asn Val Phe 
    1010                 1015                 1020             


Glu Lys  Tyr Met Leu Asp Leu  Thr Lys Glu Phe Pro  Glu Lys Phe 
    1025                 1030                 1035             


Ser Glu  Ala Phe Val Lys Ser  Met Leu Arg Asn Lys  Thr Ala Ile 
    1040                 1045                 1050             


Ile Tyr  Asn Val Glu Lys Lys  Val Val His Arg Ile  Lys Arg Leu 
    1055                 1060                 1065             


Lys Ile  Leu Ser Ser Glu Leu  Lys Glu Asn Lys Leu  Ser Asn Val 
    1070                 1075                 1080             


Ile Ile  Arg Ser Lys Asn Glu  Ser Gly Thr Lys Leu  Ser Tyr Gln 
    1085                 1090                 1095             


Asp Thr  Ile Asn Ser Ile Ala  Leu Met Ile Met Arg  Ser Ile Asp 
    1100                 1105                 1110             


Pro Thr  Ala Lys Lys Gln Tyr  Ile Arg Val Pro Leu  Asn Thr Leu 
    1115                 1120                 1125             


Asn Leu  His Leu Gly Asp Gln  Asp Phe Asp Leu His  Asn Ile Asp 
    1130                 1135                 1140             


Ala Tyr  Leu Lys Lys Pro Lys  Phe Val Lys Tyr Leu  Lys Ala Asn 
    1145                 1150                 1155             


Glu Ile  Gly Asp Glu Tyr Lys  Pro Trp Arg Val Leu  Thr Ser Gly 
    1160                 1165                 1170             


Thr Leu  Leu Ile His Lys Lys  Asp Lys Lys Leu Met  Tyr Ile Ser 
    1175                 1180                 1185             


Ser Phe  Gln Asn Leu Lys Asp  Val Ile Glu Ile Lys  Asn Leu Ile 
    1190                 1195                 1200             


Glu Thr  Glu Tyr Lys Glu Asn  Asp Asp Ser Asp Pro  Lys Lys Lys 
    1205                 1210                 1215             


Lys Lys  Ala Asn Arg Phe Leu  Met Thr Leu Ser Thr  Ile Leu Asn 
    1220                 1225                 1230             


Asp Tyr  Ile Leu Leu Asp Ala  Lys Asp Asn Phe Asp  Ile Leu Gly 
    1235                 1240                 1245             


Leu Ser  Lys Asn Arg Ile Asp  Glu Ile Leu Asn Ser  Lys Leu Gly 
    1250                 1255                 1260             


Leu Asp  Lys Ile Thr Lys 
    1265                 


<210> 331
<211> 1224
<212> PRT
<213> Mycoplasma gallisepticum

<400> 331
Met Asn Asn Ser Ile Lys Ser Lys Pro Glu Val Thr Ile Gly Leu Asp 
1               5                   10                  15      


Leu Gly Val Gly Ser Val Gly Trp Ala Ile Val Asp Asn Glu Thr Asn 
            20                  25                  30          


Ile Ile His His Leu Gly Ser Arg Leu Phe Ser Gln Ala Lys Thr Ala 
        35                  40                  45              


Glu Asp Arg Arg Ser Phe Arg Gly Ala Arg Arg Leu Ile Arg Arg Arg 
    50                  55                  60                  


Lys Tyr Lys Leu Lys Arg Phe Ile Asn Leu Ile Trp Lys Tyr Asn Ser 
65                  70                  75                  80  


Tyr Phe Gly Phe Lys Asn Lys Glu Asp Ile Leu Asn Asn Tyr Gln Glu 
                85                  90                  95      


Gln Gln Lys Leu His Asn Thr Val Leu Asn Leu Lys Leu Glu Ala Leu 
            100                 105                 110         


Asn Ala Lys Ile Asp Pro Lys Ala Leu Ser Trp Ile Leu His Asp Tyr 
        115                 120                 125             


Leu Lys Asn Arg Gly His Phe Tyr Glu Asp Asn Arg Asp Phe Asn Val 
    130                 135                 140                 


Tyr Pro Thr Glu Glu Leu Ala Asn Tyr Phe Gly Glu Tyr Gly Tyr Tyr 
145                 150                 155                 160 


Lys Gly Ile Ile Asp Ser Lys Glu Asp Asn Asp Asp Lys Leu Glu Glu 
                165                 170                 175     


Gly Leu Thr Lys Tyr Lys Phe Ser Asn Gln His Trp Leu Glu Glu Ile 
            180                 185                 190         


Lys Lys Val Leu Ser Asn Gln Thr Gly Leu Pro Glu Lys Phe Lys Glu 
        195                 200                 205             


Glu Tyr Glu Ser Leu Phe Ser Tyr Val Arg Asn Tyr Ser Glu Gly Pro 
    210                 215                 220                 


Gly Ser Ile Asn Ser Val Ser Pro Tyr Gly Ile Tyr His Leu Asp Glu 
225                 230                 235                 240 


Lys Glu Gly Lys Val Val Gln Lys Tyr Asn Asn Ile Trp Asp Lys Thr 
                245                 250                 255     


Ile Gly Lys Cys Ser Ile Phe Pro Asp Glu Tyr Arg Ala Pro Lys Asn 
            260                 265                 270         


Ser Pro Ile Ala Met Ile Phe Asn Glu Ile Asn Glu Leu Ser Thr Ile 
        275                 280                 285             


Arg Ser Tyr Ser Ile Tyr Leu Thr Gly Trp Phe Ile Asn Gln Glu Phe 
    290                 295                 300                 


Lys Lys Ala Tyr Leu Asn Lys Leu Leu Asp Leu Leu Ile Lys Thr Asn 
305                 310                 315                 320 


Ser Glu Lys Pro Ile Asp Ala Arg Gln Phe Lys Lys Leu Arg Glu Glu 
                325                 330                 335     


Thr Ile Ala Glu Ser Ile Gly Lys Glu Thr Leu Lys Asp Val Glu Arg 
            340                 345                 350         


Glu Glu Lys Leu Glu Lys Glu Asp His Lys Trp Lys Leu Lys Gly Leu 
        355                 360                 365             


Lys Leu Asn Thr Asn Gly Lys Ile Gln Tyr Asn Asp Leu Ser Ser Leu 
    370                 375                 380                 


Ala Lys Phe Val His Lys Leu Lys Gln His Leu Lys Leu Asp Phe Leu 
385                 390                 395                 400 


Leu Glu Asp Gln Tyr Thr Thr Leu Asp Lys Ile Asn Phe Leu Gln Ser 
                405                 410                 415     


Leu Phe Val Tyr Leu Gly Lys His Leu Arg Tyr Ser Asn Arg Val Asp 
            420                 425                 430         


Ser Ala Asn Leu Lys Glu Phe Ser Asp Ser Asn Lys Leu Phe Glu Arg 
        435                 440                 445             


Val Leu Gln Glu Gln Lys Asp Asp Leu Phe Lys Leu Phe Glu Gln Thr 
    450                 455                 460                 


Asp Lys Asp Asp Glu Lys Ile Leu Ala Gln Thr His Ser Leu Ser Thr 
465                 470                 475                 480 


Lys Ala Met Leu Leu Ala Ile Thr Arg Met Thr Asn Leu Asp Asn Asp 
                485                 490                 495     


Glu Asp Asn Gln Lys Asn Asn Asp Lys Gly Trp Asn Phe Glu Ala Ile 
            500                 505                 510         


Lys Asn Phe Asp Gln Lys Phe Ile Asp Ile Thr Lys Lys Asn Asn Asn 
        515                 520                 525             


Leu Ser Leu Lys Gln Asp Lys Arg Tyr Leu Asp Asp Arg Phe Ile Asn 
    530                 535                 540                 


Asp Ala Ile Leu Ser Pro Gly Val Lys Arg Ile Leu Arg Glu Ala Thr 
545                 550                 555                 560 


Lys Val Phe Asn Ala Ile Leu Lys Gln Phe Ser Glu Glu Tyr Asp Val 
                565                 570                 575     


Thr Lys Val Val Ile Glu Leu Ala Arg Glu Leu Ser Glu Glu Lys Glu 
            580                 585                 590         


Leu Glu Asn Thr Lys Asn Tyr Glu Lys Leu Ile Lys Lys Asn Ser Asp 
        595                 600                 605             


Lys Ile Ser Glu Arg Leu Glu Ala Leu Asp Ile Ala Glu Asp Lys Ile 
    610                 615                 620                 


Glu Asp Ile Leu Lys Ser Pro Thr Lys Ser Tyr Lys Val Leu Leu Trp 
625                 630                 635                 640 


Leu Gln Gln Asp His Ile Asp Pro Tyr Ser Gln Lys Glu Ile Ala Phe 
                645                 650                 655     


Glu Asp Ile Leu Thr Lys Thr Glu Lys Thr Glu Ile Asp His Ile Ile 
            660                 665                 670         


Pro Tyr Ser Ile Ser Phe Asp Asp Ser Ser Ser Asn Lys Leu Leu Val 
        675                 680                 685             


Leu Ala Glu Ser Asn Gln Ala Lys Ser Asn Gln Thr Pro Tyr Glu Phe 
    690                 695                 700                 


Ile Thr Ser Gly Asn Ala Gly Ile Lys Trp Glu Asp Tyr Glu Ala Tyr 
705                 710                 715                 720 


Cys Arg Lys Phe Lys Asp Gly Asp Thr Ser Leu Leu Asp Ser Thr Gln 
                725                 730                 735     


Arg Ser Lys Lys Phe Ala Lys Met Met Lys Thr Asp Thr Ser Ser Lys 
            740                 745                 750         


Tyr Asp Ile Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala 
        755                 760                 765             


Thr Ile Val Phe Arg Asp Ala Leu Lys Asp Tyr Ala Asn Asn His Leu 
    770                 775                 780                 


Val Glu Asp Lys Pro Met Phe Lys Val Val Cys Ile Asn Gly Gly Val 
785                 790                 795                 800 


Thr Ser Phe Leu Arg Lys Asn Phe Asp Lys Ser Trp Tyr Ala Lys Lys 
                805                 810                 815     


Asp Arg Asp Lys Asn Ile His His Ala Val Asp Ala Ser Ile Ile Ser 
            820                 825                 830         


Ile Phe Ser Asn Glu Thr Lys Thr Leu Phe Asn Gln Leu Thr Gln Phe 
        835                 840                 845             


Ala Asp Tyr Lys Leu Phe Lys Asn Thr Asp Gly Ser Trp Lys Lys Ile 
    850                 855                 860                 


Asp Pro Lys Thr Gly Val Val Thr Glu Val Thr Asp Glu Asn Trp Lys 
865                 870                 875                 880 


Gln Ile Arg Val Arg Asn Gln Val Ser Glu Ile Ala Lys Val Ile Asn 
                885                 890                 895     


Lys Cys Ile Gln Asp Ser Asn Ile Glu Arg Lys Ala Arg Tyr Ser Arg 
            900                 905                 910         


Lys Ile Glu Asn Lys Thr Asn Ile Ser Leu Phe Asn Asp Thr Val Tyr 
        915                 920                 925             


Ser Ala Lys Lys Val Gly Tyr Glu Asp Gln Ile Lys Arg Lys Asn Leu 
    930                 935                 940                 


Lys Thr Leu Asp Ile His Glu Ser Ala Glu Glu Asn Lys Asn Ser Lys 
945                 950                 955                 960 


Val Lys Lys Gln Phe Val Tyr Arg Lys Leu Val Asn Val Ser Leu Leu 
                965                 970                 975     


Asn Asn Asp Lys Leu Ala Asp Leu Phe Ala Glu Lys Glu Asp Ile Leu 
            980                 985                 990         


Met Tyr Arg Ala Asn Pro Trp Val  Ile Asn Leu Ala Glu  Gln Ile Phe 
        995                 1000                 1005             


Asn Glu  Tyr Thr Glu Asn Lys  Lys Ile Lys Ser Gln  Asn Val Phe 
    1010                 1015                 1020             


Glu Lys  Tyr Met Leu Asp Leu  Thr Lys Glu Phe Pro  Glu Lys Phe 
    1025                 1030                 1035             


Ser Glu  Ala Phe Val Lys Ser  Met Leu Arg Asn Lys  Thr Ala Ile 
    1040                 1045                 1050             


Ile Tyr  Asn Val Glu Lys Lys  Val Val His Arg Ile  Lys Arg Leu 
    1055                 1060                 1065             


Lys Ile  Leu Ser Ser Glu Leu  Lys Glu Asn Lys Leu  Ser Asn Val 
    1070                 1075                 1080             


Ile Ile  Arg Ser Lys Asn Glu  Ser Gly Thr Lys Leu  Ser Tyr Gln 
    1085                 1090                 1095             


Asp Thr  Ile Asn Ser Ile Ala  Leu Met Ile Met Arg  Ser Ile Asp 
    1100                 1105                 1110             


Pro Thr  Ala Lys Lys Gln Tyr  Ile Arg Val Pro Leu  Asn Thr Leu 
    1115                 1120                 1125             


Asn Leu  His Leu Gly Asp Gln  Asp Phe Asp Leu His  Asn Ile Asp 
    1130                 1135                 1140             


Ala Tyr  Leu Lys Lys Pro Lys  Phe Val Lys Tyr Leu  Lys Ala Asn 
    1145                 1150                 1155             


Glu Ile  Gly Asp Glu Tyr Lys  Pro Trp Arg Val Leu  Thr Ser Gly 
    1160                 1165                 1170             


Thr Leu  Leu Ile His Lys Lys  Asp Lys Lys Leu Met  Tyr Ile Ser 
    1175                 1180                 1185             


Ser Phe  Gln Asn Leu Lys Asp  Val Ile Glu Ile Lys  Asn Leu Ile 
    1190                 1195                 1200             


Glu Thr  Glu Tyr Lys Glu Asn  Asp Asp Ser Asp Pro  Lys Lys Arg 
    1205                 1210                 1215             


Arg Lys  Gln Ile Gly Ser 
    1220                 


<210> 332
<211> 1269
<212> PRT
<213> Mycoplasma gallisepticum

<400> 332
Met Asn Asn Ser Ile Lys Ser Lys Pro Glu Val Thr Ile Gly Leu Asp 
1               5                   10                  15      


Leu Gly Val Gly Ser Val Gly Trp Ala Ile Val Asp Asn Glu Thr Asn 
            20                  25                  30          


Ile Ile His His Leu Gly Ser Arg Leu Phe Ser Gln Ala Lys Thr Ala 
        35                  40                  45              


Glu Asp Arg Arg Ser Phe Arg Gly Val Arg Arg Leu Ile Arg Arg Arg 
    50                  55                  60                  


Lys Tyr Lys Leu Lys Arg Phe Val Asn Leu Ile Trp Lys Tyr Asn Ser 
65                  70                  75                  80  


Tyr Phe Gly Phe Lys Asn Lys Glu Asp Ile Leu Asn Asn Tyr Gln Glu 
                85                  90                  95      


Gln Gln Lys Leu His Asn Thr Val Leu Asn Leu Lys Ser Glu Ala Leu 
            100                 105                 110         


Asn Ala Lys Ile Asp Pro Lys Ala Leu Ser Trp Ile Leu His Asp Tyr 
        115                 120                 125             


Leu Lys Asn Arg Gly His Phe Tyr Glu Asp Asn Arg Asp Phe Asn Val 
    130                 135                 140                 


Tyr Pro Thr Lys Glu Leu Ala Lys Tyr Phe Asp Lys Tyr Gly Tyr Tyr 
145                 150                 155                 160 


Lys Gly Ile Ile Asp Ser Lys Glu Asp Asn Asp Asn Lys Leu Glu Glu 
                165                 170                 175     


Glu Leu Thr Lys Tyr Lys Phe Ser Asn Lys His Trp Leu Glu Glu Val 
            180                 185                 190         


Lys Lys Val Leu Ser Asn Gln Thr Gly Leu Pro Glu Lys Phe Lys Glu 
        195                 200                 205             


Glu Tyr Glu Ser Leu Phe Ser Tyr Val Arg Asn Tyr Ser Glu Gly Pro 
    210                 215                 220                 


Gly Ser Ile Asn Ser Val Ser Pro Tyr Gly Ile Tyr His Leu Asp Glu 
225                 230                 235                 240 


Lys Glu Gly Lys Val Val Gln Lys Tyr Asn Asn Ile Trp Asp Lys Thr 
                245                 250                 255     


Ile Gly Lys Cys Asn Ile Phe Pro Asp Glu Tyr Arg Ala Pro Lys Asn 
            260                 265                 270         


Ser Pro Ile Ala Met Ile Phe Asn Glu Ile Asn Glu Leu Ser Thr Ile 
        275                 280                 285             


Arg Ser Tyr Ser Ile Tyr Leu Thr Gly Trp Phe Ile Asn Gln Glu Phe 
    290                 295                 300                 


Lys Lys Ala Tyr Leu Asn Lys Leu Leu Asp Leu Leu Ile Lys Thr Asn 
305                 310                 315                 320 


Gly Glu Lys Pro Ile Asp Ala Arg Gln Phe Lys Lys Leu Arg Glu Glu 
                325                 330                 335     


Thr Ile Ala Glu Ser Ile Gly Lys Glu Thr Leu Lys Asp Val Glu Asn 
            340                 345                 350         


Glu Glu Lys Leu Glu Lys Glu Asp His Lys Trp Lys Leu Lys Gly Leu 
        355                 360                 365             


Lys Leu Asn Thr Asn Gly Lys Ile Gln Tyr Asn Asp Leu Ser Ser Leu 
    370                 375                 380                 


Ala Lys Phe Val His Lys Leu Lys Gln His Leu Lys Leu Asp Phe Leu 
385                 390                 395                 400 


Leu Glu Asp Gln Tyr Ala Thr Leu Asp Lys Ile Asn Phe Leu Gln Ser 
                405                 410                 415     


Leu Phe Val Tyr Leu Gly Lys His Leu Arg Tyr Ser Asn Arg Val Asp 
            420                 425                 430         


Ser Ala Asn Leu Lys Glu Phe Ser Asp Ser Asn Lys Leu Phe Glu Arg 
        435                 440                 445             


Ile Leu Gln Lys Gln Lys Asp Gly Leu Phe Lys Leu Phe Glu Gln Thr 
    450                 455                 460                 


Asp Lys Asp Asp Glu Lys Ile Leu Ala Gln Thr His Ser Leu Ser Thr 
465                 470                 475                 480 


Lys Ala Met Leu Leu Ala Ile Thr Arg Met Thr Asn Leu Asp Asn Asp 
                485                 490                 495     


Glu Asp Asn Gln Lys Asn Asn Asp Lys Gly Trp Asn Phe Glu Ala Ile 
            500                 505                 510         


Lys Asn Phe Asp Gln Lys Phe Ile Asp Ile Thr Lys Lys Asn Asn Asn 
        515                 520                 525             


Leu Ser Leu Lys Gln Asn Lys Arg Tyr Leu Asp Asp Arg Phe Ile Asn 
    530                 535                 540                 


Asp Ala Ile Leu Ser Pro Gly Val Lys Arg Ile Leu Arg Glu Ala Thr 
545                 550                 555                 560 


Lys Val Phe Asn Ala Ile Leu Lys Gln Phe Ser Glu Glu Tyr Asp Val 
                565                 570                 575     


Thr Lys Val Val Ile Glu Leu Ala Arg Glu Leu Ser Glu Glu Lys Glu 
            580                 585                 590         


Leu Glu Asn Thr Lys Asn Tyr Lys Lys Leu Ile Lys Lys Asn Gly Asp 
        595                 600                 605             


Lys Ile Ser Glu Gly Leu Lys Ala Leu Gly Ile Ser Glu Asp Glu Ile 
    610                 615                 620                 


Lys Asp Ile Leu Lys Ser Pro Thr Lys Ser Tyr Lys Phe Leu Leu Trp 
625                 630                 635                 640 


Leu Gln Gln Asp His Ile Asp Pro Tyr Ser Leu Lys Glu Ile Ala Phe 
                645                 650                 655     


Asp Asp Ile Phe Thr Lys Thr Glu Lys Phe Glu Ile Asp His Ile Ile 
            660                 665                 670         


Pro Tyr Ser Ile Ser Phe Asp Asp Ser Ser Ser Asn Lys Leu Leu Val 
        675                 680                 685             


Leu Ala Glu Ser Asn Gln Ala Lys Ser Asn Gln Thr Pro Tyr Glu Phe 
    690                 695                 700                 


Ile Ser Ser Gly Asn Ala Gly Ile Lys Trp Glu Asp Tyr Glu Ala Tyr 
705                 710                 715                 720 


Cys Arg Lys Phe Lys Asp Gly Asp Ser Ser Leu Leu Asp Ser Thr Gln 
                725                 730                 735     


Arg Ser Lys Lys Phe Ala Lys Met Met Lys Thr Asp Thr Ser Ser Lys 
            740                 745                 750         


Tyr Asp Ile Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala 
        755                 760                 765             


Thr Ile Val Phe Arg Asp Ala Leu Glu Asp Tyr Ala Asn Asn His Leu 
    770                 775                 780                 


Val Glu Asp Lys Pro Met Phe Lys Val Val Cys Ile Asn Gly Ser Val 
785                 790                 795                 800 


Thr Ser Phe Leu Arg Lys Asn Phe Asp Asp Ser Ser Tyr Ala Lys Lys 
                805                 810                 815     


Asp Arg Asp Lys Asn Ile His His Ala Val Asp Ala Ser Ile Ile Ser 
            820                 825                 830         


Ile Phe Ser Asn Glu Thr Lys Thr Leu Phe Asn Gln Leu Thr Gln Phe 
        835                 840                 845             


Ala Asp Tyr Lys Leu Phe Lys Asn Thr Asp Gly Ser Trp Lys Lys Ile 
    850                 855                 860                 


Asp Pro Lys Thr Gly Val Val Thr Glu Val Thr Asp Glu Asn Trp Lys 
865                 870                 875                 880 


Gln Ile Arg Val Arg Asn Gln Val Ser Glu Ile Ala Lys Val Ile Glu 
                885                 890                 895     


Lys Tyr Ile Gln Asp Ser Asn Ile Glu Arg Lys Ala Arg Tyr Ser Arg 
            900                 905                 910         


Lys Ile Glu Asn Lys Thr Asn Ile Ser Leu Phe Asn Asp Thr Val Tyr 
        915                 920                 925             


Ser Ala Lys Lys Val Gly Tyr Glu Asp Gln Ile Lys Arg Lys Asn Leu 
    930                 935                 940                 


Lys Thr Leu Asp Ile His Glu Ser Ala Lys Glu Asn Lys Asn Ser Lys 
945                 950                 955                 960 


Val Lys Arg Gln Phe Val Tyr Arg Lys Leu Val Asn Val Ser Leu Leu 
                965                 970                 975     


Asn Asn Asp Lys Leu Ala Asp Leu Phe Ala Glu Lys Glu Asp Ile Leu 
            980                 985                 990         


Met Tyr Arg Ala Asn Pro Trp Val  Ile Asn Leu Ala Glu  Gln Ile Phe 
        995                 1000                 1005             


Asn Glu  Tyr Thr Glu Asn Lys  Lys Ile Lys Ser Gln  Asn Val Phe 
    1010                 1015                 1020             


Glu Lys  Tyr Met Leu Asp Leu  Thr Lys Glu Phe Pro  Glu Lys Phe 
    1025                 1030                 1035             


Ser Glu  Phe Leu Val Lys Ser  Met Leu Arg Asn Lys  Thr Ala Ile 
    1040                 1045                 1050             


Ile Tyr  Asp Asp Lys Lys Asn  Ile Val His Arg Ile  Lys Arg Leu 
    1055                 1060                 1065             


Lys Met  Leu Ser Ser Glu Leu  Lys Glu Asn Lys Leu  Ser Asn Val 
    1070                 1075                 1080             


Ile Ile  Arg Ser Lys Asn Gln  Ser Gly Thr Lys Leu  Ser Tyr Gln 
    1085                 1090                 1095             


Asp Thr  Ile Asn Ser Leu Ala  Leu Met Ile Met Arg  Ser Ile Asp 
    1100                 1105                 1110             


Pro Thr  Ala Lys Lys Gln Tyr  Ile Arg Val Pro Leu  Asn Thr Leu 
    1115                 1120                 1125             


Asn Leu  His Leu Gly Asp His  Asp Phe Asp Leu His  Asn Met Asp 
    1130                 1135                 1140             


Ala Tyr  Leu Lys Lys Pro Lys  Phe Val Lys Tyr Leu  Lys Ala Asn 
    1145                 1150                 1155             


Glu Ile  Gly Asp Glu Tyr Lys  Pro Trp Arg Val Leu  Thr Ser Gly 
    1160                 1165                 1170             


Thr Leu  Leu Ile His Lys Lys  Asp Lys Lys Leu Met  Tyr Ile Ser 
    1175                 1180                 1185             


Ser Phe  Gln Asn Leu Asn Asp  Val Ile Glu Ile Lys  Asn Leu Ile 
    1190                 1195                 1200             


Glu Thr  Glu Tyr Lys Glu Asn  Asp Asp Ser Asp Ser  Lys Lys Lys 
    1205                 1210                 1215             


Lys Lys  Ala Asn Arg Phe Leu  Met Thr Leu Ser Thr  Ile Leu Asn 
    1220                 1225                 1230             


Asp Tyr  Ile Leu Leu Asp Ala  Lys Asp Asn Phe Asp  Ile Leu Gly 
    1235                 1240                 1245             


Leu Ser  Lys Asn Arg Ile Asp  Glu Ile Leu Asn Ser  Lys Leu Gly 
    1250                 1255                 1260             


Leu Asp  Lys Ile Val Lys 
    1265                 


<210> 333
<211> 1269
<212> PRT
<213> Mycoplasma gallisepticum


<220>
<223> Mycoplasma gallisepticum str. F

<400> 333
Met Asn Asn Ser Ile Lys Ser Lys Pro Glu Val Thr Ile Gly Leu Asp 
1               5                   10                  15      


Leu Gly Val Gly Ser Val Gly Trp Ala Ile Val Asp Asn Glu Thr Asn 
            20                  25                  30          


Ile Ile His His Leu Gly Ser Arg Leu Phe Ser Gln Ala Lys Thr Ala 
        35                  40                  45              


Glu Asp Arg Arg Ser Phe Arg Gly Val Arg Arg Leu Ile Arg Arg Arg 
    50                  55                  60                  


Lys Tyr Lys Leu Lys Arg Phe Val Asn Leu Ile Trp Lys Tyr Asn Ser 
65                  70                  75                  80  


Tyr Phe Gly Phe Lys Asn Lys Glu Asp Ile Leu Asn Asn Tyr Gln Glu 
                85                  90                  95      


Gln Gln Lys Leu His Asn Thr Val Leu Asn Leu Lys Ser Glu Ala Leu 
            100                 105                 110         


Asn Ala Lys Ile Asp Pro Lys Ala Leu Ser Trp Ile Leu His Asp Tyr 
        115                 120                 125             


Leu Lys Asn Arg Gly His Phe Tyr Glu Asp Asn Arg Asp Phe Asn Val 
    130                 135                 140                 


Tyr Pro Thr Lys Glu Leu Ala Lys Tyr Phe Asp Lys Tyr Gly Tyr Tyr 
145                 150                 155                 160 


Lys Gly Ile Ile Asp Ser Lys Glu Asp Asn Asp Asn Lys Leu Glu Glu 
                165                 170                 175     


Glu Leu Thr Lys Tyr Lys Phe Ser Asn Lys His Trp Leu Glu Glu Val 
            180                 185                 190         


Lys Lys Val Leu Ser Asn Gln Thr Gly Leu Pro Glu Lys Phe Lys Glu 
        195                 200                 205             


Glu Tyr Glu Ser Leu Phe Ser Tyr Val Arg Asn Tyr Ser Glu Gly Pro 
    210                 215                 220                 


Gly Ser Ile Asn Ser Val Ser Pro Tyr Gly Ile Tyr His Leu Asp Glu 
225                 230                 235                 240 


Lys Glu Gly Lys Val Val Gln Lys Tyr Asn Asn Ile Trp Asp Lys Thr 
                245                 250                 255     


Ile Gly Lys Cys Asn Ile Phe Pro Asp Glu Tyr Arg Ala Pro Lys Asn 
            260                 265                 270         


Ser Pro Ile Ala Met Ile Phe Asn Glu Ile Asn Glu Leu Ser Thr Ile 
        275                 280                 285             


Arg Ser Tyr Ser Ile Tyr Leu Thr Gly Trp Phe Ile Asn Gln Glu Phe 
    290                 295                 300                 


Lys Lys Ala Tyr Leu Asn Lys Leu Leu Asp Leu Leu Ile Lys Thr Asn 
305                 310                 315                 320 


Gly Glu Lys Pro Ile Asp Ala Arg Gln Phe Lys Lys Leu Arg Glu Glu 
                325                 330                 335     


Thr Ile Ala Glu Ser Ile Gly Lys Glu Thr Leu Lys Asp Val Glu Asn 
            340                 345                 350         


Glu Glu Lys Leu Glu Lys Glu Asp His Lys Trp Lys Leu Lys Gly Leu 
        355                 360                 365             


Lys Leu Asn Thr Asn Gly Lys Ile Gln Tyr Asn Asp Leu Ser Ser Leu 
    370                 375                 380                 


Ala Lys Phe Val His Lys Leu Lys Gln His Leu Lys Leu Asp Phe Leu 
385                 390                 395                 400 


Leu Glu Asp Gln Tyr Ala Thr Leu Asp Lys Ile Asn Phe Leu Gln Ser 
                405                 410                 415     


Leu Phe Val Tyr Leu Gly Lys His Leu Arg Tyr Ser Asn Arg Val Asp 
            420                 425                 430         


Ser Ala Asn Leu Lys Glu Phe Ser Asp Ser Asn Lys Leu Phe Glu Arg 
        435                 440                 445             


Ile Leu Gln Lys Gln Lys Asp Gly Leu Phe Lys Leu Phe Glu Gln Thr 
    450                 455                 460                 


Asp Lys Asp Asp Glu Lys Ile Leu Ala Gln Thr His Ser Leu Ser Thr 
465                 470                 475                 480 


Lys Ala Met Leu Leu Ala Ile Thr Arg Met Thr Asn Leu Asp Asn Asp 
                485                 490                 495     


Glu Asp Asn Gln Lys Asn Asn Asp Lys Gly Trp Asn Phe Glu Ala Ile 
            500                 505                 510         


Lys Asn Phe Asp Gln Lys Phe Ile Asp Ile Thr Lys Lys Asn Asn Asn 
        515                 520                 525             


Leu Ser Leu Lys Gln Asn Lys Arg Tyr Leu Asp Asp Arg Phe Ile Asn 
    530                 535                 540                 


Asp Ala Ile Leu Ser Pro Gly Val Lys Arg Ile Leu Arg Glu Ala Thr 
545                 550                 555                 560 


Lys Val Phe Asn Ala Ile Leu Lys Gln Phe Ser Glu Glu Tyr Asp Val 
                565                 570                 575     


Thr Lys Val Val Ile Glu Leu Ala Arg Glu Leu Ser Glu Glu Lys Glu 
            580                 585                 590         


Leu Glu Asn Thr Lys Asn Tyr Lys Lys Leu Ile Lys Lys Asn Gly Asp 
        595                 600                 605             


Lys Ile Ser Glu Gly Leu Lys Ala Leu Gly Ile Ser Glu Asp Glu Ile 
    610                 615                 620                 


Lys Asp Ile Leu Lys Ser Pro Thr Lys Ser Tyr Lys Phe Leu Leu Trp 
625                 630                 635                 640 


Leu Gln Gln Asp His Ile Asp Pro Tyr Ser Leu Lys Glu Ile Ala Phe 
                645                 650                 655     


Asp Asp Ile Phe Thr Lys Thr Glu Lys Phe Glu Ile Asp His Ile Ile 
            660                 665                 670         


Pro Tyr Ser Ile Ser Phe Asp Asp Ser Ser Ser Asn Lys Leu Leu Val 
        675                 680                 685             


Leu Ala Glu Ser Asn Gln Ala Lys Ser Asn Gln Thr Pro Tyr Glu Phe 
    690                 695                 700                 


Ile Ser Ser Gly Asn Ala Gly Ile Lys Trp Glu Asp Tyr Glu Ala Tyr 
705                 710                 715                 720 


Cys Arg Lys Phe Lys Asp Gly Asp Ser Ser Leu Leu Asp Ser Thr Gln 
                725                 730                 735     


Arg Ser Lys Lys Phe Ala Lys Met Met Lys Thr Asp Thr Ser Ser Lys 
            740                 745                 750         


Tyr Asp Ile Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala 
        755                 760                 765             


Thr Ile Val Phe Arg Asp Ala Leu Glu Asp Tyr Ala Asn Asn His Leu 
    770                 775                 780                 


Val Glu Asp Lys Pro Met Phe Lys Val Val Cys Ile Asn Gly Ser Val 
785                 790                 795                 800 


Thr Ser Phe Leu Arg Lys Asn Phe Asp Asp Ser Ser Tyr Ala Lys Lys 
                805                 810                 815     


Asp Arg Asp Lys Asn Ile His His Ala Val Asp Ala Ser Ile Ile Ser 
            820                 825                 830         


Ile Phe Ser Asn Glu Thr Lys Thr Leu Phe Asn Gln Leu Thr Gln Phe 
        835                 840                 845             


Ala Asp Tyr Lys Leu Phe Lys Asn Thr Asp Gly Ser Trp Lys Lys Ile 
    850                 855                 860                 


Asp Pro Lys Thr Gly Val Val Thr Glu Val Thr Asp Glu Asn Trp Lys 
865                 870                 875                 880 


Gln Ile Arg Val Arg Asn Gln Val Ser Glu Ile Ala Lys Val Ile Glu 
                885                 890                 895     


Lys Tyr Ile Gln Asp Ser Asn Ile Glu Arg Lys Ala Arg Tyr Ser Arg 
            900                 905                 910         


Lys Ile Glu Asn Lys Thr Asn Ile Ser Leu Phe Asn Asp Thr Val Tyr 
        915                 920                 925             


Ser Ala Lys Lys Val Gly Tyr Glu Asp Gln Ile Lys Arg Lys Asn Leu 
    930                 935                 940                 


Lys Thr Leu Asp Ile His Glu Ser Ala Lys Glu Asn Lys Asn Ser Lys 
945                 950                 955                 960 


Val Lys Arg Gln Phe Val Tyr Arg Lys Leu Val Asn Val Ser Leu Leu 
                965                 970                 975     


Asn Asn Asp Lys Leu Ala Asp Leu Phe Ala Glu Lys Glu Asp Ile Leu 
            980                 985                 990         


Met Tyr Arg Ala Asn Pro Trp Val  Ile Asn Leu Ala Glu  Gln Ile Phe 
        995                 1000                 1005             


Asn Glu  Tyr Thr Glu Asn Lys  Lys Ile Lys Ser Gln  Asn Val Phe 
    1010                 1015                 1020             


Glu Lys  Tyr Met Leu Asp Leu  Thr Lys Glu Phe Pro  Glu Lys Phe 
    1025                 1030                 1035             


Ser Glu  Phe Leu Val Lys Ser  Met Leu Arg Asn Lys  Thr Ala Ile 
    1040                 1045                 1050             


Ile Tyr  Asp Asp Lys Lys Asn  Ile Val His Arg Ile  Lys Arg Leu 
    1055                 1060                 1065             


Lys Met  Leu Ser Ser Glu Leu  Lys Glu Asn Lys Leu  Ser Asn Val 
    1070                 1075                 1080             


Ile Ile  Arg Ser Lys Asn Gln  Ser Gly Thr Lys Leu  Ser Tyr Gln 
    1085                 1090                 1095             


Asp Thr  Ile Asn Ser Leu Ala  Leu Met Ile Met Arg  Ser Ile Asp 
    1100                 1105                 1110             


Pro Thr  Ala Lys Lys Gln Tyr  Ile Arg Val Pro Leu  Asn Thr Leu 
    1115                 1120                 1125             


Asn Leu  His Leu Gly Asp His  Asp Phe Asp Leu His  Asn Met Asp 
    1130                 1135                 1140             


Ala Tyr  Leu Lys Lys Pro Lys  Phe Val Lys Tyr Leu  Lys Ala Asn 
    1145                 1150                 1155             


Glu Ile  Gly Asp Glu Tyr Lys  Pro Trp Arg Val Leu  Thr Ser Gly 
    1160                 1165                 1170             


Thr Leu  Leu Ile His Lys Lys  Asp Lys Lys Leu Met  Tyr Ile Ser 
    1175                 1180                 1185             


Ser Phe  Gln Asn Leu Asn Asp  Val Ile Glu Ile Lys  Asn Leu Ile 
    1190                 1195                 1200             


Glu Thr  Glu Tyr Lys Glu Asn  Asp Asp Ser Asp Ser  Lys Lys Lys 
    1205                 1210                 1215             


Lys Lys  Ala Asn Arg Phe Leu  Met Thr Leu Ser Thr  Ile Leu Asn 
    1220                 1225                 1230             


Asp Tyr  Ile Leu Leu Asp Ala  Lys Asp Asn Phe Asp  Ile Leu Gly 
    1235                 1240                 1245             


Leu Ser  Lys Asn Arg Ile Asp  Glu Ile Leu Asn Ser  Lys Leu Gly 
    1250                 1255                 1260             


Leu Asp  Lys Ile Val Lys 
    1265                 


<210> 334
<211> 1270
<212> PRT
<213> Mycoplasma gallisepticum

<400> 334
Met Asn Asn Ser Ile Lys Ser Lys Pro Glu Val Thr Ile Gly Leu Asp 
1               5                   10                  15      


Leu Gly Val Gly Ser Val Gly Trp Ala Ile Val Asp Asn Glu Thr Asn 
            20                  25                  30          


Ile Ile His His Leu Gly Ser Arg Leu Phe Ser Gln Ala Lys Thr Ala 
        35                  40                  45              


Glu Asp Arg Arg Ser Phe Arg Gly Val Arg Arg Leu Ile Arg Arg Arg 
    50                  55                  60                  


Lys Tyr Lys Leu Lys Arg Phe Val Asn Leu Ile Trp Lys Tyr Asn Ser 
65                  70                  75                  80  


Tyr Phe Gly Phe Lys Asn Lys Glu Asp Ile Leu Asn Asn Tyr Gln Glu 
                85                  90                  95      


Gln Gln Lys Leu His Asn Thr Val Leu Asn Leu Lys Leu Glu Ala Leu 
            100                 105                 110         


Asn Ala Lys Ile Asp Pro Lys Ala Leu Ser Trp Ile Leu His Asp Tyr 
        115                 120                 125             


Leu Lys Asn Arg Gly His Phe Tyr Glu Asp Asn Arg Asp Phe Asn Val 
    130                 135                 140                 


Tyr Pro Thr Glu Glu Leu Ala Asn Tyr Phe Asp Glu Phe Gly Tyr Tyr 
145                 150                 155                 160 


Lys Gly Ile Ile Asp Ser Lys Asn Asp Asp Asp Asp Lys Leu Glu Glu 
                165                 170                 175     


Gly Leu Thr Lys Tyr Lys Phe Ser Asn Gln His Trp Leu Glu Glu Val 
            180                 185                 190         


Lys Lys Val Leu Ser Asn Gln Thr Gly Leu Pro Glu Lys Phe Lys Glu 
        195                 200                 205             


Glu Tyr Glu Ser Leu Phe Ser Tyr Val Arg Asn Tyr Ser Glu Gly Pro 
    210                 215                 220                 


Gly Ser Ile Asn Ser Val Ser Pro Tyr Gly Ile Tyr His Leu Asp Glu 
225                 230                 235                 240 


Lys Glu Gly Lys Val Val Gln Lys Tyr Asn Asn Ile Trp Asp Lys Thr 
                245                 250                 255     


Ile Gly Lys Cys Ser Ile Phe Pro Asp Glu Tyr Arg Ala Pro Lys Asn 
            260                 265                 270         


Ser Pro Ile Ala Met Ile Phe Asn Glu Ile Asn Glu Leu Ser Thr Ile 
        275                 280                 285             


Arg Ser Tyr Ser Ile Tyr Leu Thr Gly Trp Phe Ile Asn Gln Glu Phe 
    290                 295                 300                 


Lys Lys Ala Tyr Leu Asn Lys Leu Leu Asp Leu Leu Ile Lys Thr Asn 
305                 310                 315                 320 


Ser Glu Lys Pro Ile Asp Ala Arg Gln Phe Lys Lys Leu Arg Glu Glu 
                325                 330                 335     


Thr Ile Ala Glu Ser Ile Gly Lys Glu Thr Leu Lys Asp Val Glu Ser 
            340                 345                 350         


Glu Glu Lys Leu Glu Lys Asp Asp His Lys Trp Lys Leu Lys Gly Leu 
        355                 360                 365             


Lys Leu Asn Thr Asn Gly Lys Ile Gln Tyr Asn Asp Leu Ser Ser Leu 
    370                 375                 380                 


Ala Lys Phe Val His Lys Leu Lys Gln His Leu Lys Leu Asp Phe Leu 
385                 390                 395                 400 


Leu Glu Asp Gln Tyr Thr Pro Leu Asp Lys Ile Asn Phe Leu Gln Ser 
                405                 410                 415     


Leu Tyr Val Tyr Leu Gly Lys His Leu Arg Tyr Ser Asn Arg Val Asp 
            420                 425                 430         


Ser Ala Asn Leu Lys Glu Phe Ser Asp Ser Ser Arg Leu Phe Glu Arg 
        435                 440                 445             


Val Leu Gln Glu Gln Lys Asp Gly Leu Phe Lys Leu Phe Glu Gln Thr 
    450                 455                 460                 


Asp Lys Asp Asp Glu Lys Ile Leu Thr Gln Thr His Ser Leu Ser Thr 
465                 470                 475                 480 


Lys Ala Met Leu Leu Ala Ile Thr Arg Met Thr Asn Leu Asp Asn Asp 
                485                 490                 495     


Glu Asp Asn Gln Lys Asn Asn Asp Lys Gly Trp Asn Phe Glu Ala Ile 
            500                 505                 510         


Lys Asn Phe Asp Gln Lys Phe Ile Asp Ile Thr Lys Thr Asn Asn Asn 
        515                 520                 525             


Leu Ser Leu Lys Gln Asp Lys Arg Tyr Leu Asp Asp Gln Phe Ile Asn 
    530                 535                 540                 


Asp Ala Ile Leu Ser Pro Gly Val Lys Arg Ile Leu Arg Glu Ala Thr 
545                 550                 555                 560 


Lys Val Phe Asn Ala Ile Leu Lys Gln Phe Ser Glu Glu Tyr Asp Val 
                565                 570                 575     


Thr Lys Val Val Ile Glu Leu Ala Arg Glu Leu Ser Glu Glu Lys Glu 
            580                 585                 590         


Leu Glu Asn Thr Lys Asn Tyr Lys Lys Leu Ile Lys Lys Asn Gly Asp 
        595                 600                 605             


Lys Ile Ser Glu Gly Leu Lys Ala Leu Gly Ile Ala Glu Asp Lys Ile 
    610                 615                 620                 


Glu Glu Ile Leu Lys Ser Pro Thr Lys Ser Tyr Lys Val Leu Leu Trp 
625                 630                 635                 640 


Leu Gln Gln Asp His Ile Asp Pro Tyr Ser Gln Lys Glu Ile Ala Phe 
                645                 650                 655     


Asp Asp Ile Leu Thr Lys Thr Glu Lys Thr Glu Ile Asp His Ile Ile 
            660                 665                 670         


Pro Tyr Ser Ile Ser Phe Asp Asp Ser Ser Ser Asn Lys Leu Leu Val 
        675                 680                 685             


Leu Ala Glu Ser Asn Gln Ala Lys Ser Asn Gln Thr Pro Tyr Glu Phe 
    690                 695                 700                 


Ile Asn Ser Gly Lys Ala Glu Ile Thr Trp Glu Val Tyr Glu Ala Tyr 
705                 710                 715                 720 


Cys His Lys Phe Lys Asn Gly Asp Ser Ser Leu Leu Asp Ser Thr Gln 
                725                 730                 735     


Arg Ser Lys Lys Phe Ala Lys Met Met Lys Thr Asp Thr Ser Ser Lys 
            740                 745                 750         


Tyr Asp Ile Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala 
        755                 760                 765             


Thr Ile Val Phe Arg Asp Ala Leu Lys Asp Tyr Ala Asn Asn His Leu 
    770                 775                 780                 


Val Glu Asp Lys Pro Met Phe Lys Val Val Cys Ile Asn Gly Gly Val 
785                 790                 795                 800 


Thr Ser Phe Leu Arg Lys Asn Phe Asp Pro Lys Ser Trp Tyr Ala Lys 
                805                 810                 815     


Lys Asp Arg Asp Lys Asn Ile His His Ala Val Asp Ala Ser Ile Ile 
            820                 825                 830         


Ser Ile Phe Ser Asn Glu Thr Lys Thr Leu Phe Asn Gln Leu Thr Lys 
        835                 840                 845             


Phe Ala Asp Tyr Lys Leu Phe Lys Asn Thr Asp Gly Ser Trp Lys Lys 
    850                 855                 860                 


Ile Asp Pro Lys Thr Gly Val Val Ser Glu Val Thr Asp Glu Asn Trp 
865                 870                 875                 880 


Lys Gln Ile Arg Val Arg Asn Gln Val Ser Glu Ile Ala Lys Val Ile 
                885                 890                 895     


Asp Lys Tyr Ile Gln Asp Ser Asn Ile Glu Arg Lys Ala Arg Tyr Ser 
            900                 905                 910         


Arg Lys Ile Glu Asn Lys Thr Asn Ile Ser Leu Phe Asn Asp Thr Val 
        915                 920                 925             


Tyr Ser Ala Lys Lys Val Gly Tyr Glu Asp Gln Ile Lys Arg Lys Asn 
    930                 935                 940                 


Leu Lys Thr Leu Asp Ile His Glu Ser Ala Glu Glu Asn Lys Asn Ser 
945                 950                 955                 960 


Lys Val Lys Lys Gln Phe Val Tyr Arg Lys Leu Val Asn Val Ser Leu 
                965                 970                 975     


Leu Asn Asn Asp Lys Leu Ala Asp Leu Phe Ala Glu Lys Glu Asp Ile 
            980                 985                 990         


Leu Met Tyr Arg Ala Asn Pro Trp  Val Ile Asn Leu Ala  Glu Gln Ile 
        995                 1000                 1005             


Phe Asn  Glu Tyr Thr Glu Asn  Lys Lys Ile Lys Ser  Gln Asn Val 
    1010                 1015                 1020             


Phe Glu  Lys Tyr Met Leu Asp  Leu Thr Lys Glu Phe  Pro Glu Lys 
    1025                 1030                 1035             


Phe Ser  Glu Ala Phe Val Lys  Ser Met Ile Arg Asn  Lys Thr Ala 
    1040                 1045                 1050             


Ile Ile  Tyr Asn Val Glu Lys  Asp Val Val His Arg  Ile Lys Arg 
    1055                 1060                 1065             


Leu Lys  Ile Leu Ser Ser Glu  Leu Lys Glu Asn Lys  Trp Ser Asn 
    1070                 1075                 1080             


Val Ile  Ile Arg Ser Lys Asn  Glu Ser Gly Thr Lys  Leu Ser Tyr 
    1085                 1090                 1095             


Gln Asp  Thr Ile Asn Ser Ile  Ala Leu Met Ile Met  Arg Ser Ile 
    1100                 1105                 1110             


Asp Pro  Thr Ala Lys Lys Gln  Tyr Ile Arg Val Pro  Leu Asn Thr 
    1115                 1120                 1125             


Leu Asn  Leu His Leu Gly Asp  Gln Asp Phe Asp Leu  His Asn Ile 
    1130                 1135                 1140             


Asp Ala  Tyr Leu Lys Lys Pro  Lys Phe Val Lys Tyr  Leu Lys Ala 
    1145                 1150                 1155             


Asn Glu  Ile Gly Asp Glu Tyr  Lys Pro Trp Arg Val  Leu Thr Ser 
    1160                 1165                 1170             


Gly Thr  Leu Leu Ile His Lys  Lys Asp Lys Lys Leu  Met Tyr Ile 
    1175                 1180                 1185             


Ser Ser  Phe Gln Asn Leu Asn  Asp Leu Ile Glu Ile  Lys Asn Leu 
    1190                 1195                 1200             


Ile Glu  Thr Glu Tyr Lys Glu  Asn Val Asp Ser Asp  Pro Lys Lys 
    1205                 1210                 1215             


Lys Lys  Lys Ala Ser Gln Ile  Leu Arg Ser Leu Ser  Val Ile Leu 
    1220                 1225                 1230             


Asn Asp  Tyr Ile Leu Leu Asp  Ala Lys Tyr Asn Phe  Asp Ile Leu 
    1235                 1240                 1245             


Gly Leu  Ser Lys Asn Lys Ile  Asp Glu Ile Leu Asn  Ser Lys Leu 
    1250                 1255                 1260             


Asp Leu  Asp Lys Ile Ala Lys  
    1265                 1270 


<210> 335
<211> 1236
<212> PRT
<213> Mycoplasma mobile

<400> 335
Met Tyr Phe Tyr Lys Asn Lys Glu Asn Lys Leu Asn Lys Lys Val Val 
1               5                   10                  15      


Leu Gly Leu Asp Leu Gly Ile Ala Ser Val Gly Trp Cys Leu Thr Asp 
            20                  25                  30          


Ile Ser Gln Lys Glu Asp Asn Lys Phe Pro Ile Ile Leu His Gly Val 
        35                  40                  45              


Arg Leu Phe Glu Thr Val Asp Asp Ser Asp Asp Lys Leu Leu Asn Glu 
    50                  55                  60                  


Thr Arg Arg Lys Lys Arg Gly Gln Arg Arg Arg Asn Arg Arg Leu Phe 
65                  70                  75                  80  


Thr Arg Lys Arg Asp Phe Ile Lys Tyr Leu Ile Asp Asn Asn Ile Ile 
                85                  90                  95      


Glu Leu Glu Phe Asp Lys Asn Pro Lys Ile Leu Val Arg Asn Phe Ile 
            100                 105                 110         


Glu Lys Tyr Ile Asn Pro Phe Ser Lys Asn Leu Glu Leu Lys Tyr Lys 
        115                 120                 125             


Ser Val Thr Asn Leu Pro Ile Gly Phe His Asn Leu Arg Lys Ala Ala 
    130                 135                 140                 


Ile Asn Glu Lys Tyr Lys Leu Asp Lys Ser Glu Leu Ile Val Leu Leu 
145                 150                 155                 160 


Tyr Phe Tyr Leu Ser Leu Arg Gly Ala Phe Phe Asp Asn Pro Glu Asp 
                165                 170                 175     


Thr Lys Ser Lys Glu Met Asn Lys Asn Glu Ile Glu Ile Phe Asp Lys 
            180                 185                 190         


Asn Glu Ser Ile Lys Asn Ala Glu Phe Pro Ile Asp Lys Ile Ile Glu 
        195                 200                 205             


Phe Tyr Lys Ile Ser Gly Lys Ile Arg Ser Thr Ile Asn Leu Lys Phe 
    210                 215                 220                 


Gly His Gln Asp Tyr Leu Lys Glu Ile Lys Gln Val Phe Glu Lys Gln 
225                 230                 235                 240 


Asn Ile Asp Phe Met Asn Tyr Glu Lys Phe Ala Met Glu Glu Lys Ser 
                245                 250                 255     


Phe Phe Ser Arg Ile Arg Asn Tyr Ser Glu Gly Pro Gly Asn Glu Lys 
            260                 265                 270         


Ser Phe Ser Lys Tyr Gly Leu Tyr Ala Asn Glu Asn Gly Asn Pro Glu 
        275                 280                 285             


Leu Ile Ile Asn Glu Lys Gly Gln Lys Ile Tyr Thr Lys Ile Phe Lys 
    290                 295                 300                 


Thr Leu Trp Glu Ser Lys Ile Gly Lys Cys Ser Tyr Asp Lys Lys Leu 
305                 310                 315                 320 


Tyr Arg Ala Pro Lys Asn Ser Phe Ser Ala Lys Val Phe Asp Ile Thr 
                325                 330                 335     


Asn Lys Leu Thr Asp Trp Lys His Lys Asn Glu Tyr Ile Ser Glu Arg 
            340                 345                 350         


Leu Lys Arg Lys Ile Leu Leu Ser Arg Phe Leu Asn Lys Asp Ser Lys 
        355                 360                 365             


Ser Ala Val Glu Lys Ile Leu Lys Glu Glu Asn Ile Lys Phe Glu Asn 
    370                 375                 380                 


Leu Ser Glu Ile Ala Tyr Asn Lys Asp Asp Asn Lys Ile Asn Leu Pro 
385                 390                 395                 400 


Ile Ile Asn Ala Tyr His Ser Leu Thr Thr Ile Phe Lys Lys His Leu 
                405                 410                 415     


Ile Asn Phe Glu Asn Tyr Leu Ile Ser Asn Glu Asn Asp Leu Ser Lys 
            420                 425                 430         


Leu Met Ser Phe Tyr Lys Gln Gln Ser Glu Lys Leu Phe Val Pro Asn 
        435                 440                 445             


Glu Lys Gly Ser Tyr Glu Ile Asn Gln Asn Asn Asn Val Leu His Ile 
    450                 455                 460                 


Phe Asp Ala Ile Ser Asn Ile Leu Asn Lys Phe Ser Thr Ile Gln Asp 
465                 470                 475                 480 


Arg Ile Arg Ile Leu Glu Gly Tyr Phe Glu Phe Ser Asn Leu Lys Lys 
                485                 490                 495     


Asp Val Lys Ser Ser Glu Ile Tyr Ser Glu Ile Ala Lys Leu Arg Glu 
            500                 505                 510         


Phe Ser Gly Thr Ser Ser Leu Ser Phe Gly Ala Tyr Tyr Lys Phe Ile 
        515                 520                 525             


Pro Asn Leu Ile Ser Glu Gly Ser Lys Asn Tyr Ser Thr Ile Ser Tyr 
    530                 535                 540                 


Glu Glu Lys Ala Leu Gln Asn Gln Lys Asn Asn Phe Ser His Ser Asn 
545                 550                 555                 560 


Leu Phe Glu Lys Thr Trp Val Glu Asp Leu Ile Ala Ser Pro Thr Val 
                565                 570                 575     


Lys Arg Ser Leu Arg Gln Thr Met Asn Leu Leu Lys Glu Ile Phe Lys 
            580                 585                 590         


Tyr Ser Glu Lys Asn Asn Leu Glu Ile Glu Lys Ile Val Val Glu Val 
        595                 600                 605             


Thr Arg Ser Ser Asn Asn Lys His Glu Arg Lys Lys Ile Glu Gly Ile 
    610                 615                 620                 


Asn Lys Tyr Arg Lys Glu Lys Tyr Glu Glu Leu Lys Lys Val Tyr Asp 
625                 630                 635                 640 


Leu Pro Asn Glu Asn Thr Thr Leu Leu Lys Lys Leu Trp Leu Leu Arg 
                645                 650                 655     


Gln Gln Gln Gly Tyr Asp Ala Tyr Ser Leu Arg Lys Ile Glu Ala Asn 
            660                 665                 670         


Asp Val Ile Asn Lys Pro Trp Asn Tyr Asp Ile Asp His Ile Val Pro 
        675                 680                 685             


Arg Ser Ile Ser Phe Asp Asp Ser Phe Ser Asn Leu Val Ile Val Asn 
    690                 695                 700                 


Lys Leu Asp Asn Ala Lys Lys Ser Asn Asp Leu Ser Ala Lys Gln Phe 
705                 710                 715                 720 


Ile Glu Lys Ile Tyr Gly Ile Glu Lys Leu Lys Glu Ala Lys Glu Asn 
                725                 730                 735     


Trp Gly Asn Trp Tyr Leu Arg Asn Ala Asn Gly Lys Ala Phe Asn Asp 
            740                 745                 750         


Lys Gly Lys Phe Ile Lys Leu Tyr Thr Ile Asp Asn Leu Asp Glu Phe 
        755                 760                 765             


Asp Asn Ser Asp Phe Ile Asn Arg Asn Leu Ser Asp Thr Ser Tyr Ile 
    770                 775                 780                 


Thr Asn Ala Leu Val Asn His Leu Thr Phe Ser Asn Ser Lys Tyr Lys 
785                 790                 795                 800 


Tyr Ser Val Val Ser Val Asn Gly Lys Gln Thr Ser Asn Leu Arg Asn 
                805                 810                 815     


Gln Ile Ala Phe Val Gly Ile Lys Asn Asn Lys Glu Thr Glu Arg Glu 
            820                 825                 830         


Trp Lys Arg Pro Glu Gly Phe Lys Ser Ile Asn Ser Asn Asp Phe Leu 
        835                 840                 845             


Ile Arg Glu Glu Gly Lys Asn Asp Val Lys Asp Asp Val Leu Ile Lys 
    850                 855                 860                 


Asp Arg Ser Phe Asn Gly His His Ala Glu Asp Ala Tyr Phe Ile Thr 
865                 870                 875                 880 


Ile Ile Ser Gln Tyr Phe Arg Ser Phe Lys Arg Ile Glu Arg Leu Asn 
                885                 890                 895     


Val Asn Tyr Arg Lys Glu Thr Arg Glu Leu Asp Asp Leu Glu Lys Asn 
            900                 905                 910         


Asn Ile Lys Phe Lys Glu Lys Ala Ser Phe Asp Asn Phe Leu Leu Ile 
        915                 920                 925             


Asn Ala Leu Asp Glu Leu Asn Glu Lys Leu Asn Gln Met Arg Phe Ser 
    930                 935                 940                 


Arg Met Val Ile Thr Lys Lys Asn Thr Gln Leu Phe Asn Glu Thr Leu 
945                 950                 955                 960 


Tyr Ser Gly Lys Tyr Asp Lys Gly Lys Asn Thr Ile Lys Lys Val Glu 
                965                 970                 975     


Lys Leu Asn Leu Leu Asp Asn Arg Thr Asp Lys Ile Lys Lys Ile Glu 
            980                 985                 990         


Glu Phe Phe Asp Glu Asp Lys Leu  Lys Glu Asn Glu Leu  Thr Lys Leu 
        995                 1000                 1005             


His Ile  Phe Asn His Asp Lys  Asn Leu Tyr Glu Thr  Leu Lys Ile 
    1010                 1015                 1020             


Ile Trp  Asn Glu Val Lys Ile  Glu Ile Lys Asn Lys  Asn Leu Asn 
    1025                 1030                 1035             


Glu Lys  Asn Tyr Phe Lys Tyr  Phe Val Asn Lys Lys  Leu Gln Glu 
    1040                 1045                 1050             


Gly Lys  Ile Ser Phe Asn Glu  Trp Val Pro Ile Leu  Asp Asn Asp 
    1055                 1060                 1065             


Phe Lys  Ile Ile Arg Lys Ile  Arg Tyr Ile Lys Phe  Ser Ser Glu 
    1070                 1075                 1080             


Glu Lys  Glu Thr Asp Glu Ile  Ile Phe Ser Gln Ser  Asn Phe Leu 
    1085                 1090                 1095             


Lys Ile  Asp Gln Arg Gln Asn  Phe Ser Phe His Asn  Thr Leu Tyr 
    1100                 1105                 1110             


Trp Val  Gln Ile Trp Val Tyr  Lys Asn Gln Lys Asp  Gln Tyr Cys 
    1115                 1120                 1125             


Phe Ile  Ser Ile Asp Ala Arg  Asn Ser Lys Phe Glu  Lys Asp Glu 
    1130                 1135                 1140             


Ile Lys  Ile Asn Tyr Glu Lys  Leu Lys Thr Gln Lys  Glu Lys Leu 
    1145                 1150                 1155             


Gln Ile  Ile Asn Glu Glu Pro  Ile Leu Lys Ile Asn  Lys Gly Asp 
    1160                 1165                 1170             


Leu Phe  Glu Asn Glu Glu Lys  Glu Leu Phe Tyr Ile  Val Gly Arg 
    1175                 1180                 1185             


Asp Glu  Lys Pro Gln Lys Leu  Glu Ile Lys Tyr Ile  Leu Gly Lys 
    1190                 1195                 1200             


Lys Ile  Lys Asp Gln Lys Gln  Ile Gln Lys Pro Val  Lys Lys Tyr 
    1205                 1210                 1215             


Phe Pro  Asn Trp Lys Lys Val  Asn Leu Thr Tyr Met  Gly Glu Ile 
    1220                 1225                 1230             


Phe Lys  Lys 
    1235     


<210> 336
<211> 1265
<212> PRT
<213> Mycoplasma ovipneumoniae


<220>
<223> Mycoplasma ovipneumoniae SC01

<400> 336
Met His Asn Lys Lys Asn Ile Thr Ile Gly Phe Asp Leu Gly Ile Ala 
1               5                   10                  15      


Ser Ile Gly Trp Ala Ile Ile Asp Ser Thr Thr Ser Lys Ile Leu Asp 
            20                  25                  30          


Trp Gly Thr Arg Thr Phe Glu Glu Arg Lys Thr Ala Asn Glu Arg Arg 
        35                  40                  45              


Ala Phe Arg Ser Thr Arg Arg Asn Ile Arg Arg Lys Ala Tyr Arg Asn 
    50                  55                  60                  


Gln Arg Phe Ile Asn Leu Ile Leu Lys Tyr Lys Asp Leu Phe Glu Leu 
65                  70                  75                  80  


Lys Asn Ile Ser Asp Ile Gln Arg Ala Asn Lys Lys Asp Thr Glu Asn 
                85                  90                  95      


Tyr Glu Lys Ile Ile Ser Phe Phe Thr Glu Ile Tyr Lys Lys Cys Ala 
            100                 105                 110         


Ala Lys His Ser Asn Ile Leu Glu Val Lys Val Lys Ala Leu Asp Ser 
        115                 120                 125             


Lys Ile Glu Lys Leu Asp Leu Ile Trp Ile Leu His Asp Tyr Leu Glu 
    130                 135                 140                 


Asn Arg Gly Phe Phe Tyr Asp Leu Glu Glu Glu Asn Val Ala Asp Lys 
145                 150                 155                 160 


Tyr Glu Gly Ile Glu His Pro Ser Ile Leu Leu Tyr Asp Phe Phe Lys 
                165                 170                 175     


Lys Asn Gly Phe Phe Lys Ser Asn Ser Ser Ile Pro Lys Asp Leu Gly 
            180                 185                 190         


Gly Tyr Ser Phe Ser Asn Leu Gln Trp Val Asn Glu Ile Lys Lys Leu 
        195                 200                 205             


Phe Glu Val Gln Glu Ile Asn Pro Glu Phe Ser Glu Lys Phe Leu Asn 
    210                 215                 220                 


Leu Phe Thr Ser Val Arg Asp Tyr Ala Lys Gly Pro Gly Ser Glu His 
225                 230                 235                 240 


Ser Ala Ser Glu Tyr Gly Ile Phe Gln Lys Asp Glu Lys Gly Lys Val 
                245                 250                 255     


Phe Lys Lys Tyr Asp Asn Ile Trp Asp Lys Thr Ile Gly Lys Cys Ser 
            260                 265                 270         


Phe Phe Val Glu Glu Asn Arg Ser Pro Val Asn Tyr Pro Ser Tyr Glu 
        275                 280                 285             


Ile Phe Asn Leu Leu Asn Gln Leu Ile Asn Leu Ser Thr Asp Leu Lys 
    290                 295                 300                 


Thr Thr Asn Lys Lys Ile Trp Gln Leu Ser Ser Asn Asp Arg Asn Glu 
305                 310                 315                 320 


Leu Leu Asp Glu Leu Leu Lys Val Lys Glu Lys Ala Lys Ile Ile Ser 
                325                 330                 335     


Ile Ser Leu Lys Lys Asn Glu Ile Lys Lys Ile Ile Leu Lys Asp Phe 
            340                 345                 350         


Gly Phe Glu Lys Ser Asp Ile Asp Asp Gln Asp Thr Ile Glu Gly Arg 
        355                 360                 365             


Lys Ile Ile Lys Glu Glu Pro Thr Thr Lys Leu Glu Val Thr Lys His 
    370                 375                 380                 


Leu Leu Ala Thr Ile Tyr Ser His Ser Ser Asp Ser Asn Trp Ile Asn 
385                 390                 395                 400 


Ile Asn Asn Ile Leu Glu Phe Leu Pro Tyr Leu Asp Ala Ile Cys Ile 
                405                 410                 415     


Ile Leu Asp Arg Glu Lys Ser Arg Gly Gln Asp Glu Val Leu Lys Lys 
            420                 425                 430         


Leu Thr Glu Lys Asn Ile Phe Glu Val Leu Lys Ile Asp Arg Glu Lys 
        435                 440                 445             


Gln Leu Asp Phe Val Lys Ser Ile Phe Ser Asn Thr Lys Phe Asn Phe 
    450                 455                 460                 


Lys Lys Ile Gly Asn Phe Ser Leu Lys Ala Ile Arg Glu Phe Leu Pro 
465                 470                 475                 480 


Lys Met Phe Glu Gln Asn Lys Asn Ser Glu Tyr Leu Lys Trp Lys Asp 
                485                 490                 495     


Glu Glu Ile Arg Arg Lys Trp Glu Glu Gln Lys Ser Lys Leu Gly Lys 
            500                 505                 510         


Thr Asp Lys Lys Thr Lys Tyr Leu Asn Pro Arg Ile Phe Gln Asp Glu 
        515                 520                 525             


Ile Ile Ser Pro Gly Thr Lys Asn Thr Phe Glu Gln Ala Val Leu Val 
    530                 535                 540                 


Leu Asn Gln Ile Ile Lys Lys Tyr Ser Lys Glu Asn Ile Ile Asp Ala 
545                 550                 555                 560 


Ile Ile Ile Glu Ser Pro Arg Glu Lys Asn Asp Lys Lys Thr Ile Glu 
                565                 570                 575     


Glu Ile Lys Lys Arg Asn Lys Lys Gly Lys Gly Lys Thr Leu Glu Lys 
            580                 585                 590         


Leu Phe Gln Ile Leu Asn Leu Glu Asn Lys Gly Tyr Lys Leu Ser Asp 
        595                 600                 605             


Leu Glu Thr Lys Pro Ala Lys Leu Leu Asp Arg Leu Arg Phe Tyr His 
    610                 615                 620                 


Gln Gln Asp Gly Ile Asp Leu Tyr Thr Leu Asp Lys Ile Asn Ile Asp 
625                 630                 635                 640 


Gln Leu Ile Asn Gly Ser Gln Lys Tyr Glu Ile Glu His Ile Ile Pro 
                645                 650                 655     


Tyr Ser Met Ser Tyr Asp Asn Ser Gln Ala Asn Lys Ile Leu Thr Glu 
            660                 665                 670         


Lys Ala Glu Asn Leu Lys Lys Gly Lys Leu Ile Ala Ser Glu Tyr Ile 
        675                 680                 685             


Lys Arg Asn Gly Asp Glu Phe Tyr Asn Lys Tyr Tyr Glu Lys Ala Lys 
    690                 695                 700                 


Glu Leu Phe Ile Asn Lys Tyr Lys Lys Asn Lys Lys Leu Asp Ser Tyr 
705                 710                 715                 720 


Val Asp Leu Asp Glu Asp Ser Ala Lys Asn Arg Phe Arg Phe Leu Thr 
                725                 730                 735     


Leu Gln Asp Tyr Asp Glu Phe Gln Val Glu Phe Leu Ala Arg Asn Leu 
            740                 745                 750         


Asn Asp Thr Arg Tyr Ser Thr Lys Leu Phe Tyr His Ala Leu Val Glu 
        755                 760                 765             


His Phe Glu Asn Asn Glu Phe Phe Thr Tyr Ile Asp Glu Asn Ser Ser 
    770                 775                 780                 


Lys His Lys Val Lys Ile Ser Thr Ile Lys Gly His Val Thr Lys Tyr 
785                 790                 795                 800 


Phe Arg Ala Lys Pro Val Gln Lys Asn Asn Gly Pro Asn Glu Asn Leu 
                805                 810                 815     


Asn Asn Asn Lys Pro Glu Lys Ile Glu Lys Asn Arg Glu Asn Asn Glu 
            820                 825                 830         


His His Ala Val Asp Ala Ala Ile Val Ala Ile Ile Gly Asn Lys Asn 
        835                 840                 845             


Pro Gln Ile Ala Asn Leu Leu Thr Leu Ala Asp Asn Lys Thr Asp Lys 
    850                 855                 860                 


Lys Phe Leu Leu His Asp Glu Asn Tyr Lys Glu Asn Ile Glu Thr Gly 
865                 870                 875                 880 


Glu Leu Val Lys Ile Pro Lys Phe Glu Val Asp Lys Leu Ala Lys Val 
                885                 890                 895     


Glu Asp Leu Lys Lys Ile Ile Gln Glu Lys Tyr Glu Glu Ala Lys Lys 
            900                 905                 910         


His Thr Ala Ile Lys Phe Ser Arg Lys Thr Arg Thr Ile Leu Asn Gly 
        915                 920                 925             


Gly Leu Ser Asp Glu Thr Leu Tyr Gly Phe Lys Tyr Asp Glu Lys Glu 
    930                 935                 940                 


Asp Lys Tyr Phe Lys Ile Ile Lys Lys Lys Leu Val Thr Ser Lys Asn 
945                 950                 955                 960 


Glu Glu Leu Lys Lys Tyr Phe Glu Asn Pro Phe Gly Lys Lys Ala Asp 
                965                 970                 975     


Gly Lys Ser Glu Tyr Thr Val Leu Met Ala Gln Ser His Leu Ser Glu 
            980                 985                 990         


Phe Asn Lys Leu Lys Glu Ile Phe  Glu Lys Tyr Asn Gly  Phe Ser Asn 
        995                 1000                 1005             


Lys Thr  Gly Asn Ala Phe Val  Glu Tyr Met Asn Asp  Leu Ala Leu 
    1010                 1015                 1020             


Lys Glu  Pro Thr Leu Lys Ala  Glu Ile Glu Ser Ala  Lys Ser Val 
    1025                 1030                 1035             


Glu Lys  Leu Leu Tyr Tyr Asn  Phe Lys Pro Ser Asp  Gln Phe Thr 
    1040                 1045                 1050             


Tyr His  Asp Asn Ile Asn Asn  Lys Ser Phe Lys Arg  Phe Tyr Lys 
    1055                 1060                 1065             


Asn Ile  Arg Ile Ile Glu Tyr  Lys Ser Ile Pro Ile  Lys Phe Lys 
    1070                 1075                 1080             


Ile Leu  Ser Lys His Asp Gly  Gly Lys Ser Phe Lys  Asp Thr Leu 
    1085                 1090                 1095             


Phe Ser  Leu Tyr Ser Leu Val  Tyr Lys Val Tyr Glu  Asn Gly Lys 
    1100                 1105                 1110             


Glu Ser  Tyr Lys Ser Ile Pro  Val Thr Ser Gln Met  Arg Asn Phe 
    1115                 1120                 1125             


Gly Ile  Asp Glu Phe Asp Phe  Leu Asp Glu Asn Leu  Tyr Asn Lys 
    1130                 1135                 1140             


Glu Lys  Leu Asp Ile Tyr Lys  Ser Asp Phe Ala Lys  Pro Ile Pro 
    1145                 1150                 1155             


Val Asn  Cys Lys Pro Val Phe  Val Leu Lys Lys Gly  Ser Ile Leu 
    1160                 1165                 1170             


Lys Lys  Lys Ser Leu Asp Ile  Asp Asp Phe Lys Glu  Thr Lys Glu 
    1175                 1180                 1185             


Thr Glu  Glu Gly Asn Tyr Tyr  Phe Ile Ser Thr Ile  Ser Lys Arg 
    1190                 1195                 1200             


Phe Asn  Arg Asp Thr Ala Tyr  Gly Leu Lys Pro Leu  Lys Leu Ser 
    1205                 1210                 1215             


Val Val  Lys Pro Val Ala Glu  Pro Ser Thr Asn Pro  Ile Phe Lys 
    1220                 1225                 1230             


Glu Tyr  Ile Pro Ile His Leu  Asp Glu Leu Gly Asn  Glu Tyr Pro 
    1235                 1240                 1245             


Val Lys  Ile Lys Glu His Thr  Asp Asp Glu Lys Leu  Met Cys Thr 
    1250                 1255                 1260             


Ile Lys  
    1265 


<210> 337
<211> 1314
<212> PRT
<213> Mycoplasma synoviae

<400> 337
Met Leu Arg Leu Tyr Cys Ala Asn Asn Leu Val Leu Asn Asn Val Gln 
1               5                   10                  15      


Asn Leu Trp Lys Tyr Leu Leu Leu Leu Ile Phe Asp Lys Lys Ile Ile 
            20                  25                  30          


Phe Leu Phe Lys Ile Lys Val Ile Leu Ile Arg Arg Tyr Met Glu Asn 
        35                  40                  45              


Asn Asn Lys Glu Lys Ile Val Ile Gly Phe Asp Leu Gly Val Ala Ser 
    50                  55                  60                  


Val Gly Trp Ser Ile Val Asn Ala Glu Thr Lys Glu Val Ile Asp Leu 
65                  70                  75                  80  


Gly Val Arg Leu Phe Ser Glu Pro Glu Lys Ala Asp Tyr Arg Arg Ala 
                85                  90                  95      


Lys Arg Thr Thr Arg Arg Leu Leu Arg Arg Lys Lys Phe Lys Arg Glu 
            100                 105                 110         


Lys Phe His Lys Leu Ile Leu Lys Asn Ala Glu Ile Phe Gly Leu Gln 
        115                 120                 125             


Ser Arg Asn Glu Ile Leu Asn Val Tyr Lys Asp Gln Ser Ser Lys Tyr 
    130                 135                 140                 


Arg Asn Ile Leu Lys Leu Lys Ile Asn Ala Leu Lys Glu Glu Ile Lys 
145                 150                 155                 160 


Pro Ser Glu Leu Val Trp Ile Leu Arg Asp Tyr Leu Gln Asn Arg Gly 
                165                 170                 175     


Tyr Phe Tyr Lys Asn Glu Lys Leu Thr Asp Glu Phe Val Ser Asn Ser 
            180                 185                 190         


Phe Pro Ser Lys Lys Leu His Glu His Tyr Glu Lys Tyr Gly Phe Phe 
        195                 200                 205             


Arg Gly Ser Val Lys Leu Asp Asn Lys Leu Asp Asn Lys Lys Asp Lys 
    210                 215                 220                 


Ala Lys Glu Lys Asp Glu Glu Glu Glu Ser Asp Ala Lys Lys Glu Ser 
225                 230                 235                 240 


Glu Glu Leu Ile Phe Ser Asn Lys Gln Trp Ile Asn Glu Ile Val Lys 
                245                 250                 255     


Val Phe Glu Asn Gln Ser Tyr Leu Thr Glu Ser Phe Lys Glu Glu Tyr 
            260                 265                 270         


Leu Lys Leu Phe Asn Tyr Val Arg Pro Phe Asn Lys Gly Pro Gly Ser 
        275                 280                 285             


Lys Asn Ser Arg Thr Ala Tyr Gly Val Phe Ser Thr Asp Ile Asp Pro 
    290                 295                 300                 


Glu Thr Asn Lys Phe Lys Asp Tyr Ser Asn Ile Trp Asp Lys Thr Ile 
305                 310                 315                 320 


Gly Lys Cys Ser Leu Phe Glu Glu Glu Ile Arg Ala Pro Lys Asn Leu 
                325                 330                 335     


Pro Ser Ala Leu Ile Phe Asn Leu Gln Asn Glu Ile Cys Thr Ile Lys 
            340                 345                 350         


Asn Glu Phe Thr Glu Phe Lys Asn Trp Trp Leu Asn Ala Glu Gln Lys 
        355                 360                 365             


Ser Glu Ile Leu Lys Phe Val Phe Thr Glu Leu Phe Asn Trp Lys Asp 
    370                 375                 380                 


Lys Lys Tyr Ser Asp Lys Lys Phe Asn Lys Asn Leu Gln Asp Lys Ile 
385                 390                 395                 400 


Lys Lys Tyr Leu Leu Asn Phe Ala Leu Glu Asn Phe Asn Leu Asn Glu 
                405                 410                 415     


Glu Ile Leu Lys Asn Arg Asp Leu Glu Asn Asp Thr Val Leu Gly Leu 
            420                 425                 430         


Lys Gly Val Lys Tyr Tyr Glu Lys Ser Asn Ala Thr Ala Asp Ala Ala 
        435                 440                 445             


Leu Glu Phe Ser Ser Leu Lys Pro Leu Tyr Val Phe Ile Lys Phe Leu 
    450                 455                 460                 


Lys Glu Lys Lys Leu Asp Leu Asn Tyr Leu Leu Gly Leu Glu Asn Thr 
465                 470                 475                 480 


Glu Ile Leu Tyr Phe Leu Asp Ser Ile Tyr Leu Ala Ile Ser Tyr Ser 
                485                 490                 495     


Ser Asp Leu Lys Glu Arg Asn Glu Trp Phe Lys Lys Leu Leu Lys Glu 
            500                 505                 510         


Leu Tyr Pro Lys Ile Lys Asn Asn Asn Leu Glu Ile Ile Glu Asn Val 
        515                 520                 525             


Glu Asp Ile Phe Glu Ile Thr Asp Gln Glu Lys Phe Glu Ser Phe Ser 
    530                 535                 540                 


Lys Thr His Ser Leu Ser Arg Glu Ala Phe Asn His Ile Ile Pro Leu 
545                 550                 555                 560 


Leu Leu Ser Asn Asn Glu Gly Lys Asn Tyr Glu Ser Leu Lys His Ser 
                565                 570                 575     


Asn Glu Glu Leu Lys Lys Arg Thr Glu Lys Ala Glu Leu Lys Ala Gln 
            580                 585                 590         


Gln Asn Gln Lys Tyr Leu Lys Asp Asn Phe Leu Lys Glu Ala Leu Val 
        595                 600                 605             


Pro Leu Ser Val Lys Thr Ser Val Leu Gln Ala Ile Lys Ile Phe Asn 
    610                 615                 620                 


Gln Ile Ile Lys Asn Phe Gly Lys Lys Tyr Glu Ile Ser Gln Val Val 
625                 630                 635                 640 


Ile Glu Met Ala Arg Glu Leu Thr Lys Pro Asn Leu Glu Lys Leu Leu 
                645                 650                 655     


Asn Asn Ala Thr Asn Ser Asn Ile Lys Ile Leu Lys Glu Lys Leu Asp 
            660                 665                 670         


Gln Thr Glu Lys Phe Asp Asp Phe Thr Lys Lys Lys Phe Ile Asp Lys 
        675                 680                 685             


Ile Glu Asn Ser Val Val Phe Arg Asn Lys Leu Phe Leu Trp Phe Glu 
    690                 695                 700                 


Gln Asp Arg Lys Asp Pro Tyr Thr Gln Leu Asp Ile Lys Ile Asn Glu 
705                 710                 715                 720 


Ile Glu Asp Glu Thr Glu Ile Asp His Val Ile Pro Tyr Ser Lys Ser 
                725                 730                 735     


Ala Asp Asp Ser Trp Phe Asn Lys Leu Leu Val Lys Lys Ser Thr Asn 
            740                 745                 750         


Gln Leu Lys Lys Asn Lys Thr Val Trp Glu Tyr Tyr Gln Asn Glu Ser 
        755                 760                 765             


Asp Pro Glu Ala Lys Trp Asn Lys Phe Val Ala Trp Ala Lys Arg Ile 
    770                 775                 780                 


Tyr Leu Val Gln Lys Ser Asp Lys Glu Ser Lys Asp Asn Ser Glu Lys 
785                 790                 795                 800 


Asn Ser Ile Phe Lys Asn Lys Lys Pro Asn Leu Lys Phe Lys Asn Ile 
                805                 810                 815     


Thr Lys Lys Leu Phe Asp Pro Tyr Lys Asp Leu Gly Phe Leu Ala Arg 
            820                 825                 830         


Asn Leu Asn Asp Thr Arg Tyr Ala Thr Lys Val Phe Arg Asp Gln Leu 
        835                 840                 845             


Asn Asn Tyr Ser Lys His His Ser Lys Asp Asp Glu Asn Lys Leu Phe 
    850                 855                 860                 


Lys Val Val Cys Met Asn Gly Ser Ile Thr Ser Phe Leu Arg Lys Ser 
865                 870                 875                 880 


Met Trp Arg Lys Asn Glu Glu Gln Val Tyr Arg Phe Asn Phe Trp Lys 
                885                 890                 895     


Lys Asp Arg Asp Gln Phe Phe His His Ala Val Asp Ala Ser Ile Ile 
            900                 905                 910         


Ala Ile Phe Ser Leu Leu Thr Lys Thr Leu Tyr Asn Lys Leu Arg Val 
        915                 920                 925             


Tyr Glu Ser Tyr Asp Val Gln Arg Arg Glu Asp Gly Val Tyr Leu Ile 
    930                 935                 940                 


Asn Lys Glu Thr Gly Glu Val Lys Lys Ala Asp Lys Asp Tyr Trp Lys 
945                 950                 955                 960 


Asp Gln His Asn Phe Leu Lys Ile Arg Glu Asn Ala Ile Glu Ile Lys 
                965                 970                 975     


Asn Val Leu Asn Asn Val Asp Phe Gln Asn Gln Val Arg Tyr Ser Arg 
            980                 985                 990         


Lys Ala Asn Thr Lys Leu Asn Thr  Gln Leu Phe Asn Glu  Thr Leu Tyr 
        995                 1000                 1005             


Gly Val  Lys Glu Phe Glu Asn  Asn Phe Tyr Lys Leu  Glu Lys Val 
    1010                 1015                 1020             


Asn Leu  Phe Ser Arg Lys Asp  Leu Arg Lys Phe Ile  Leu Glu Asp 
    1025                 1030                 1035             


Leu Asn  Glu Glu Ser Glu Lys  Asn Lys Lys Asn Glu  Asn Gly Ser 
    1040                 1045                 1050             


Arg Lys  Arg Ile Leu Thr Glu  Lys Tyr Ile Val Asp  Glu Ile Leu 
    1055                 1060                 1065             


Gln Ile  Leu Glu Asn Glu Glu  Phe Lys Asp Ser Lys  Ser Asp Ile 
    1070                 1075                 1080             


Asn Ala  Leu Asn Lys Tyr Met  Asp Ser Leu Pro Ser  Lys Phe Ser 
    1085                 1090                 1095             


Glu Phe  Phe Ser Gln Asp Phe  Ile Asn Lys Cys Lys  Lys Glu Asn 
    1100                 1105                 1110             


Ser Leu  Ile Leu Thr Phe Asp  Ala Ile Lys His Asn  Asp Pro Lys 
    1115                 1120                 1125             


Lys Val  Ile Lys Ile Lys Asn  Leu Lys Phe Phe Arg  Glu Asp Ala 
    1130                 1135                 1140             


Thr Leu  Lys Asn Lys Gln Ala  Val His Lys Asp Ser  Lys Asn Gln 
    1145                 1150                 1155             


Ile Lys  Ser Phe Tyr Glu Ser  Tyr Lys Cys Val Gly  Phe Ile Trp 
    1160                 1165                 1170             


Leu Lys  Asn Lys Asn Asp Leu  Glu Glu Ser Ile Phe  Val Pro Ile 
    1175                 1180                 1185             


Asn Ser  Arg Val Ile His Phe  Gly Asp Lys Asp Lys  Asp Ile Phe 
    1190                 1195                 1200             


Asp Phe  Asp Ser Tyr Asn Lys  Glu Lys Leu Leu Asn  Glu Ile Asn 
    1205                 1210                 1215             


Leu Lys  Arg Pro Glu Asn Lys  Lys Phe Asn Ser Ile  Asn Glu Ile 
    1220                 1225                 1230             


Glu Phe  Val Lys Phe Val Lys  Pro Gly Ala Leu Leu  Leu Asn Phe 
    1235                 1240                 1245             


Glu Asn  Gln Gln Ile Tyr Tyr  Ile Ser Thr Leu Glu  Ser Ser Ser 
    1250                 1255                 1260             


Leu Arg  Ala Lys Ile Lys Leu  Leu Asn Lys Met Asp  Lys Gly Lys 
    1265                 1270                 1275             


Ala Val  Ser Met Lys Lys Ile  Thr Asn Pro Asp Glu  Tyr Lys Ile 
    1280                 1285                 1290             


Ile Glu  His Val Asn Pro Leu  Gly Ile Asn Leu Asn  Trp Thr Lys 
    1295                 1300                 1305             


Lys Leu  Glu Asn Asn Asn 
    1310                 


<210> 338
<211> 1304
<212> PRT
<213> Mycoplasma synoviae


<220>
<223> Mycoplasma synoviae 53

<400> 338
Met Leu Asn Asn Val Gln Asn Leu Trp Lys Tyr Leu Leu Leu Leu Ile 
1               5                   10                  15      


Phe Asp Lys Lys Ile Ile Phe Leu Phe Lys Ile Lys Val Ile Leu Ile 
            20                  25                  30          


Arg Arg Tyr Met Glu Asn Asn Asn Lys Glu Lys Ile Val Ile Gly Phe 
        35                  40                  45              


Asp Leu Gly Val Ala Ser Val Gly Trp Ser Ile Val Asn Ala Glu Thr 
    50                  55                  60                  


Lys Glu Val Ile Asp Leu Gly Val Arg Leu Phe Ser Glu Pro Glu Lys 
65                  70                  75                  80  


Ala Asp Tyr Arg Arg Ala Lys Arg Thr Thr Arg Arg Leu Leu Arg Arg 
                85                  90                  95      


Lys Lys Phe Lys Arg Glu Lys Phe His Lys Leu Ile Leu Lys Asn Ala 
            100                 105                 110         


Glu Ile Phe Gly Leu Gln Ser Arg Asn Glu Ile Leu Asn Val Tyr Lys 
        115                 120                 125             


Asp Gln Ser Ser Lys Tyr Arg Asn Ile Leu Lys Leu Lys Ile Asn Ala 
    130                 135                 140                 


Leu Lys Glu Glu Ile Lys Pro Ser Glu Leu Val Trp Ile Leu Arg Asp 
145                 150                 155                 160 


Tyr Leu Gln Asn Arg Gly Tyr Phe Tyr Lys Asn Glu Lys Leu Thr Asp 
                165                 170                 175     


Glu Phe Val Ser Asn Ser Phe Pro Ser Lys Lys Leu His Glu His Tyr 
            180                 185                 190         


Glu Lys Tyr Gly Phe Phe Arg Gly Ser Val Lys Leu Asp Asn Lys Leu 
        195                 200                 205             


Asp Asn Lys Lys Asp Lys Ala Lys Glu Lys Asp Glu Glu Glu Glu Ser 
    210                 215                 220                 


Asp Ala Lys Lys Glu Ser Glu Glu Leu Ile Phe Ser Asn Lys Gln Trp 
225                 230                 235                 240 


Ile Asn Glu Ile Val Lys Val Phe Glu Asn Gln Ser Tyr Leu Thr Glu 
                245                 250                 255     


Ser Phe Lys Glu Glu Tyr Leu Lys Leu Phe Asn Tyr Val Arg Pro Phe 
            260                 265                 270         


Asn Lys Gly Pro Gly Ser Lys Asn Ser Arg Thr Ala Tyr Gly Val Phe 
        275                 280                 285             


Ser Thr Asp Ile Asp Pro Glu Thr Asn Lys Phe Lys Asp Tyr Ser Asn 
    290                 295                 300                 


Ile Trp Asp Lys Thr Ile Gly Lys Cys Ser Leu Phe Glu Glu Glu Ile 
305                 310                 315                 320 


Arg Ala Pro Lys Asn Leu Pro Ser Ala Leu Ile Phe Asn Leu Gln Asn 
                325                 330                 335     


Glu Ile Cys Thr Ile Lys Asn Glu Phe Thr Glu Phe Lys Asn Trp Trp 
            340                 345                 350         


Leu Asn Ala Glu Gln Lys Ser Glu Ile Leu Lys Phe Val Phe Thr Glu 
        355                 360                 365             


Leu Phe Asn Trp Lys Asp Lys Lys Tyr Ser Asp Lys Lys Phe Asn Lys 
    370                 375                 380                 


Asn Leu Gln Asp Lys Ile Lys Lys Tyr Leu Leu Asn Phe Ala Leu Glu 
385                 390                 395                 400 


Asn Phe Asn Leu Asn Glu Glu Ile Leu Lys Asn Arg Asp Leu Glu Asn 
                405                 410                 415     


Asp Thr Val Leu Gly Leu Lys Gly Val Lys Tyr Tyr Glu Lys Ser Asn 
            420                 425                 430         


Ala Thr Ala Asp Ala Ala Leu Glu Phe Ser Ser Leu Lys Pro Leu Tyr 
        435                 440                 445             


Val Phe Ile Lys Phe Leu Lys Glu Lys Lys Leu Asp Leu Asn Tyr Leu 
    450                 455                 460                 


Leu Gly Leu Glu Asn Thr Glu Ile Leu Tyr Phe Leu Asp Ser Ile Tyr 
465                 470                 475                 480 


Leu Ala Ile Ser Tyr Ser Ser Asp Leu Lys Glu Arg Asn Glu Trp Phe 
                485                 490                 495     


Lys Lys Leu Leu Lys Glu Leu Tyr Pro Lys Ile Lys Asn Asn Asn Leu 
            500                 505                 510         


Glu Ile Ile Glu Asn Val Glu Asp Ile Phe Glu Ile Thr Asp Gln Glu 
        515                 520                 525             


Lys Phe Glu Ser Phe Ser Lys Thr His Ser Leu Ser Arg Glu Ala Phe 
    530                 535                 540                 


Asn His Ile Ile Pro Leu Leu Leu Ser Asn Asn Glu Gly Lys Asn Tyr 
545                 550                 555                 560 


Glu Ser Leu Lys His Ser Asn Glu Glu Leu Lys Lys Arg Thr Glu Lys 
                565                 570                 575     


Ala Glu Leu Lys Ala Gln Gln Asn Gln Lys Tyr Leu Lys Asp Asn Phe 
            580                 585                 590         


Leu Lys Glu Ala Leu Val Pro Leu Ser Val Lys Thr Ser Val Leu Gln 
        595                 600                 605             


Ala Ile Lys Ile Phe Asn Gln Ile Ile Lys Asn Phe Gly Lys Lys Tyr 
    610                 615                 620                 


Glu Ile Ser Gln Val Val Ile Glu Met Ala Arg Glu Leu Thr Lys Pro 
625                 630                 635                 640 


Asn Leu Glu Lys Leu Leu Asn Asn Ala Thr Asn Ser Asn Ile Lys Ile 
                645                 650                 655     


Leu Lys Glu Lys Leu Asp Gln Thr Glu Lys Phe Asp Asp Phe Thr Lys 
            660                 665                 670         


Lys Lys Phe Ile Asp Lys Ile Glu Asn Ser Val Val Phe Arg Asn Lys 
        675                 680                 685             


Leu Phe Leu Trp Phe Glu Gln Asp Arg Lys Asp Pro Tyr Thr Gln Leu 
    690                 695                 700                 


Asp Ile Lys Ile Asn Glu Ile Glu Asp Glu Thr Glu Ile Asp His Val 
705                 710                 715                 720 


Ile Pro Tyr Ser Lys Ser Ala Asp Asp Ser Trp Phe Asn Lys Leu Leu 
                725                 730                 735     


Val Lys Lys Ser Thr Asn Gln Leu Lys Lys Asn Lys Thr Val Trp Glu 
            740                 745                 750         


Tyr Tyr Gln Asn Glu Ser Asp Pro Glu Ala Lys Trp Asn Lys Phe Val 
        755                 760                 765             


Ala Trp Ala Lys Arg Ile Tyr Leu Val Gln Lys Ser Asp Lys Glu Ser 
    770                 775                 780                 


Lys Asp Asn Ser Glu Lys Asn Ser Ile Phe Lys Asn Lys Lys Pro Asn 
785                 790                 795                 800 


Leu Lys Phe Lys Asn Ile Thr Lys Lys Leu Phe Asp Pro Tyr Lys Asp 
                805                 810                 815     


Leu Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Lys 
            820                 825                 830         


Val Phe Arg Asp Gln Leu Asn Asn Tyr Ser Lys His His Ser Lys Asp 
        835                 840                 845             


Asp Glu Asn Lys Leu Phe Lys Val Val Cys Met Asn Gly Ser Ile Thr 
    850                 855                 860                 


Ser Phe Leu Arg Lys Ser Met Trp Arg Lys Asn Glu Glu Gln Val Tyr 
865                 870                 875                 880 


Arg Phe Asn Phe Trp Lys Lys Asp Arg Asp Gln Phe Phe His His Ala 
                885                 890                 895     


Val Asp Ala Ser Ile Ile Ala Ile Phe Ser Leu Leu Thr Lys Thr Leu 
            900                 905                 910         


Tyr Asn Lys Leu Arg Val Tyr Glu Ser Tyr Asp Val Gln Arg Arg Glu 
        915                 920                 925             


Asp Gly Val Tyr Leu Ile Asn Lys Glu Thr Gly Glu Val Lys Lys Ala 
    930                 935                 940                 


Asp Lys Asp Tyr Trp Lys Asp Gln His Asn Phe Leu Lys Ile Arg Glu 
945                 950                 955                 960 


Asn Ala Ile Glu Ile Lys Asn Val Leu Asn Asn Val Asp Phe Gln Asn 
                965                 970                 975     


Gln Val Arg Tyr Ser Arg Lys Ala Asn Thr Lys Leu Asn Thr Gln Leu 
            980                 985                 990         


Phe Asn Glu Thr Leu Tyr Gly Val  Lys Glu Phe Glu Asn  Asn Phe Tyr 
        995                 1000                 1005             


Lys Leu  Glu Lys Val Asn Leu  Phe Ser Arg Lys Asp  Leu Arg Lys 
    1010                 1015                 1020             


Phe Ile  Leu Glu Asp Leu Asn  Glu Glu Ser Glu Lys  Asn Lys Lys 
    1025                 1030                 1035             


Asn Glu  Asn Gly Ser Arg Lys  Arg Ile Leu Thr Glu  Lys Tyr Ile 
    1040                 1045                 1050             


Val Asp  Glu Ile Leu Gln Ile  Leu Glu Asn Glu Glu  Phe Lys Asp 
    1055                 1060                 1065             


Ser Lys  Ser Asp Ile Asn Ala  Leu Asn Lys Tyr Met  Asp Ser Leu 
    1070                 1075                 1080             


Pro Ser  Lys Phe Ser Glu Phe  Phe Ser Gln Asp Phe  Ile Asn Lys 
    1085                 1090                 1095             


Cys Lys  Lys Glu Asn Ser Leu  Ile Leu Thr Phe Asp  Ala Ile Lys 
    1100                 1105                 1110             


His Asn  Asp Pro Lys Lys Val  Ile Lys Ile Lys Asn  Leu Lys Phe 
    1115                 1120                 1125             


Phe Arg  Glu Asp Ala Thr Leu  Lys Asn Lys Gln Ala  Val His Lys 
    1130                 1135                 1140             


Asp Ser  Lys Asn Gln Ile Lys  Ser Phe Tyr Glu Ser  Tyr Lys Cys 
    1145                 1150                 1155             


Val Gly  Phe Ile Trp Leu Lys  Asn Lys Asn Asp Leu  Glu Glu Ser 
    1160                 1165                 1170             


Ile Phe  Val Pro Ile Asn Ser  Arg Val Ile His Phe  Gly Asp Lys 
    1175                 1180                 1185             


Asp Lys  Asp Ile Phe Asp Phe  Asp Ser Tyr Asn Lys  Glu Lys Leu 
    1190                 1195                 1200             


Leu Asn  Glu Ile Asn Leu Lys  Arg Pro Glu Asn Lys  Lys Phe Asn 
    1205                 1210                 1215             


Ser Ile  Asn Glu Ile Glu Phe  Val Lys Phe Val Lys  Pro Gly Ala 
    1220                 1225                 1230             


Leu Leu  Leu Asn Phe Glu Asn  Gln Gln Ile Tyr Tyr  Ile Ser Thr 
    1235                 1240                 1245             


Leu Glu  Ser Ser Ser Leu Arg  Ala Lys Ile Lys Leu  Leu Asn Lys 
    1250                 1255                 1260             


Met Asp  Lys Gly Lys Ala Val  Ser Met Lys Lys Ile  Thr Asn Pro 
    1265                 1270                 1275             


Asp Glu  Tyr Lys Ile Ile Glu  His Val Asn Pro Leu  Gly Ile Asn 
    1280                 1285                 1290             


Leu Asn  Trp Thr Lys Lys Leu  Glu Asn Asn Asn 
    1295                 1300                 


<210> 339
<211> 1401
<212> PRT
<213> Myroides injenensis


<220>
<223> Myroides injenensis M09-0166

<400> 339
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Tyr Val His Glu Ala Glu Asn Val Asn Glu Thr Ser Ser Ile Gln 
            20                  25                  30          


Lys Val Gly Val Arg Val Asn Pro Leu Thr Thr Glu Glu Gln Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Pro Ile Thr Thr Asn Ala Ser Arg Thr Leu Ala 
    50                  55                  60                  


Arg Ser Ala Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Asp Asn 
65                  70                  75                  80  


Leu Ile Gln Ile Leu Lys Glu Asn Asn Trp Ile Asn Asn Thr Thr Ser 
                85                  90                  95      


Leu Thr Glu Thr Gly Asn His Ser Thr Phe Glu Thr Tyr Glu Leu Arg 
            100                 105                 110         


Asn Lys Ala Ala Ser Glu Lys Leu Thr Leu Asp Gln Leu Ser Arg Val 
        115                 120                 125             


Leu Leu Met Leu Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Val 
    130                 135                 140                 


Asn Ser Lys Glu Glu Gly Gln Leu Ile Asp Gly Met Glu Val Ala Lys 
145                 150                 155                 160 


Lys Leu Tyr His Glu Gln Leu Thr Pro Gly Gln Leu Ser Leu Gln Leu 
                165                 170                 175     


Met Asn Gln Gly Val Lys Lys Leu Pro Asp Tyr Tyr Arg Ser Asp Leu 
            180                 185                 190         


Asn Gln Glu Leu Glu Ser Ile Trp Asn Phe Gln Gln Gln Phe Tyr Pro 
        195                 200                 205             


Asn Ile Leu Thr Asp Lys Phe Lys Glu Glu Ile Asn Gly Lys Gly Leu 
    210                 215                 220                 


Thr Ser Thr Ser Ser Ala Phe Trp Asn Ile Tyr Asn Phe Asn Thr Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Ser Arg Asp Glu Lys Lys Lys Gln Ala Leu Gln Trp 
                245                 250                 255     


Arg Ser Glu Ala Leu Ser Lys Gln Leu Ser Lys Glu Ile Val Ala Tyr 
            260                 265                 270         


Ile Ile Ala Asp Leu Asn Gly Gln Ile Tyr Asn Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Asn Leu Thr 
    290                 295                 300                 


Val Gly Gln Tyr Leu Phe Lys Gln Leu Lys Ser Asn Pro His Thr Ser 
305                 310                 315                 320 


Leu Lys Asn Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asn Glu Phe Glu 
                325                 330                 335     


Lys Ile Trp Glu Thr Gln Ser Lys Phe Tyr Pro Lys Glu Leu Thr Ala 
            340                 345                 350         


Ala Leu Lys Arg Glu Ile Arg Asp Val Ile Ile Phe Tyr Gln Arg Lys 
        355                 360                 365             


Leu Lys Ser Gln Lys Gly Leu Ile Ser Phe Cys Glu Phe Glu Gln Lys 
    370                 375                 380                 


Gln Lys Thr Ile Asn Gly Lys Thr Lys Thr Ile Gly His Arg Val Ile 
385                 390                 395                 400 


Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln Gln Leu 
                405                 410                 415     


His Asn Val Val Leu Arg Asn Lys Lys Thr Asn Glu Ile Val Ser Leu 
            420                 425                 430         


Ala Asp Glu Gln Lys Val His Leu Phe Glu Glu Leu Asn Leu Lys Gly 
        435                 440                 445             


Lys Leu Lys Ser Asn Gln Val Leu Lys Leu Ile Glu Asn Lys Pro Lys 
    450                 455                 460                 


Asp Trp Glu Leu Asn Tyr Thr Glu Leu Glu Gly Asn Asn Thr Asn Lys 
465                 470                 475                 480 


Ala Leu Tyr Asn Ala Tyr Leu Asp Ile Leu Asp Ile Glu Gly Tyr Asp 
                485                 490                 495     


Val Arg Asn Glu Leu Lys Val Lys Leu Asn Lys Asp Asp Ile Glu Leu 
            500                 505                 510         


Ser Asp Leu Asp Val Asn Ala Ser Glu Ile Lys Glu Met Ile Phe Ser 
        515                 520                 525             


Val Phe Lys His Leu Gly Ile Asn Thr Glu Ile Leu Glu Phe Asp Ala 
    530                 535                 540                 


Thr Leu Glu Asp Lys Val Phe Glu Lys Gln Ala Ser Tyr Gln Leu Trp 
545                 550                 555                 560 


His Leu Leu Tyr Ser Tyr Glu Glu Asp Asn Ser Pro Thr Gly Leu Asp 
                565                 570                 575     


Arg Leu Tyr Asn Leu Leu His Lys Lys Phe Gly Phe Lys Leu Asn His 
            580                 585                 590         


Ala Lys Leu Ile Gly Asn Val Leu Phe Gln Asp Asp Tyr Gly Ser Leu 
        595                 600                 605             


Ser Ser Lys Ala Ile Lys Asn Ile Phe Pro Tyr Ile Thr Glu Asn Asn 
    610                 615                 620                 


Tyr Tyr Thr Ala Cys Glu Leu Ala Gly Tyr Lys His Ser Lys His Ser 
625                 630                 635                 640 


Leu Thr Lys Glu Glu Asn Glu Thr Arg Glu Leu Lys Asn Arg Leu Thr 
                645                 650                 655     


Ile Leu Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Ile 
            660                 665                 670         


Asn Gln Met Ile Asn Val Val Asn Thr Leu Ile Asp Glu Glu Asn Asn 
        675                 680                 685             


Ile Leu Ile Ala Gln Gly Lys Glu Pro Asn Phe Gln Phe Asp Glu Ile 
    690                 695                 700                 


Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn Ala Lys Glu Arg Glu 
705                 710                 715                 720 


Glu Leu Thr Lys Ser Ile Asn Lys Ser Lys Thr Asp His Glu Lys Ile 
                725                 730                 735     


Ile Lys Ile Leu Gln Lys Glu Asp Gly Ile Lys Asn Pro Thr Arg Asn 
            740                 745                 750         


Asp Ile Val Arg Phe Lys Leu Tyr Ser Glu Leu Lys Asn Asn Gly Tyr 
        755                 760                 765             


Lys Asp Leu Tyr Thr Asn Glu Tyr Ile Glu Arg Lys Asp Ile Phe Thr 
    770                 775                 780                 


Lys Glu Tyr Asp Ile Glu His Ile Ile Pro Gln Ser Lys Leu Phe Asp 
785                 790                 795                 800 


Asp Ser Phe Ser Asn Lys Thr Leu Val Arg Arg Asn Val Asn Leu Lys 
                805                 810                 815     


Lys Gly Asn Gln Thr Ala Tyr Asp Phe Ile Leu Cys Glu Tyr Gly Gln 
            820                 825                 830         


Glu Lys Ala Asn Glu Phe Glu Thr Arg Ile Thr Asn Leu Tyr Asn Leu 
        835                 840                 845             


Gly Lys Asp Glu Gly Ile Ser Lys Ser Lys Phe Lys Lys Leu Leu Met 
    850                 855                 860                 


Gln Glu Ser Glu Ile Gly Asn Gly Phe Ile Glu Arg Asp Leu Arg Glu 
865                 870                 875                 880 


Thr Gln Tyr Ile Ala Lys Lys Ala Lys Ser Leu Leu Leu Glu Ile Thr 
                885                 890                 895     


Arg Asn Val Ile Ser Thr Ser Gly Ser Ile Thr Asp Arg Leu Arg Glu 
            900                 905                 910         


Asp Trp Gly Leu Ile Asn Val Met Lys Glu Leu Asn Leu Gln Lys Tyr 
        915                 920                 925             


Arg Asp Ala Gly Leu Thr Glu Phe Val Lys Met Lys Asp Gly Asn Lys 
    930                 935                 940                 


Lys Glu Val Ile Ile Asp Trp Thr Lys Arg Asn Asp His Arg His His 
945                 950                 955                 960 


Ala Met Asp Ala Leu Thr Ile Ala Phe Thr Lys His Asn His Ile Gln 
                965                 970                 975     


Tyr Leu Asn His Leu Asn Ala Arg Lys Asn Val Asn Asn Glu Leu His 
            980                 985                 990         


Asn Asn Ile Ile Ala Ile Glu Lys  Leu Glu Thr Thr Leu  Val Ser Asp 
        995                 1000                 1005             


Glu Arg  Gly Asn Lys Lys Arg  Ile Phe Lys Glu Pro  Ile Ala Asn 
    1010                 1015                 1020             


Phe Arg  Thr Ile Ala Lys Ser  His Leu Glu Ala Ile  Leu Val Ser 
    1025                 1030                 1035             


His Lys  Ala Lys Asn Lys Val  Val Thr Lys Asn Ile  Asn Lys Ile 
    1040                 1045                 1050             


Ser Gly  Lys Lys Ile Ser Gln  Gln Thr Leu Thr Pro  Arg Gly Gln 
    1055                 1060                 1065             


Leu His  Lys Glu Thr Ile Tyr  Gly Lys Ile Arg Gln  Tyr Val Ser 
    1070                 1075                 1080             


Lys Gln  Glu Lys Val Gly Pro  Lys Phe Thr Ile Glu  Val Ile Glu 
    1085                 1090                 1095             


Gln Val  Ser Asn Pro Thr Tyr  Arg Asn Leu Leu Leu  Lys Arg Leu 
    1100                 1105                 1110             


Glu Glu  Asn Asn Asn Asp Pro  Lys Lys Ala Phe Gly  Gly Lys Asn 
    1115                 1120                 1125             


Ser Leu  Asn Lys Asn Pro Ile  Tyr Ile Asn Leu Glu  Lys Asn Ile 
    1130                 1135                 1140             


Lys Val  Pro Glu Val Leu Lys  Leu Val Trp Leu Glu  Asp Asn Tyr 
    1145                 1150                 1155             


Thr Ile  Arg Lys Glu Ile Ser  Pro Asp Leu Lys Ile  Asp Lys Val 
    1160                 1165                 1170             


Ile Asp  Gln Gly Val Lys Gln  Ile Leu Gln Asn Arg  Leu Ala Gln 
    1175                 1180                 1185             


Tyr Lys  Gly Asp Ser Lys Leu  Ala Phe Ser Asn Leu  Asp Ala Asn 
    1190                 1195                 1200             


Pro Ile  Trp Leu Asn Glu Asp  Lys Gly Ile Ala Ile  Lys Arg Val 
    1205                 1210                 1215             


Thr Ile  Ser Gly Ile Ala Thr  Ala Gln Pro Leu His  Arg Lys Lys 
    1220                 1225                 1230             


Asp His  Leu Gly Gln Pro Ile  Leu Asp His Asn Gly  Gln Glu Ile 
    1235                 1240                 1245             


Pro Val  Asp Phe Ile Ser Thr  Gly Asn Asn His His  Val Ala Ile 
    1250                 1255                 1260             


Tyr Glu  Asp Glu Asn Gly Lys  Leu Gln Glu Ser Val  Val Ser His 
    1265                 1270                 1275             


Phe Glu  Ala Val Glu Arg Val  Asn Gln Lys Leu Pro  Ile Ile Asp 
    1280                 1285                 1290             


Lys Thr  Phe Asn Gln His Leu  Gly Trp Lys Phe Leu  Phe Thr Met 
    1295                 1300                 1305             


Lys Gln  Asn Glu Leu Phe Leu  Phe Pro Ser Asp Asp  Phe Asn Pro 
    1310                 1315                 1320             


Asn Glu  Ile Asp Leu Phe Asp  Lys Gln Asn Tyr Thr  Val Ile Ser 
    1325                 1330                 1335             


Lys His  Leu Phe Arg Ile Gln  Lys Leu Ser Thr Lys  Asp Tyr Ser 
    1340                 1345                 1350             


Phe Arg  His His Leu Glu Thr  Asn Val Glu Glu Ile  Lys Asp Leu 
    1355                 1360                 1365             


Lys Thr  Ile Thr Trp Arg Arg  Glu Gly Leu Asn Gly  Ile Gln Asn 
    1370                 1375                 1380             


Ile Ile  Lys Val Arg Thr Asn  His Leu Gly Glu Ile  Ile His Ile 
    1385                 1390                 1395             


Gly Glu  Tyr 
    1400     


<210> 340
<211> 1466
<212> PRT
<213> Myroides odoratus


<220>
<223> Myroides odoratus DSM 2801

<400> 340
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Lys Glu Asp Phe Glu Asn Lys Gln Gly Glu Ile Leu Gly 
            20                  25                  30          


Leu Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Ile Leu Gly Glu Phe 
        35                  40                  45              


Gly Arg Gly Asn Ser Ile Ser Gln Thr Ala Asp Arg Thr Gly Tyr Arg 
    50                  55                  60                  


Gly Val Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu Asn Ile Leu Gly Phe Leu Pro Asn His Tyr Ala Lys 
                85                  90                  95      


Glu Ile Asp Phe Thr Lys Arg Leu Gly Lys Phe Ile Asn His Ala Glu 
            100                 105                 110         


Pro Lys Leu Ser Phe Asp Lys Glu Phe Ile Phe Lys Asp Ser Phe Asn 
        115                 120                 125             


Glu Met Leu Lys Asp Phe Gln Gln Asn Gln Pro Gly Phe Ile Ile Asn 
    130                 135                 140                 


Lys His Gly Glu Glu Ala Leu Val Pro Tyr Asp Trp Thr Ile Tyr Tyr 
145                 150                 155                 160 


Leu Arg Lys Lys Ala Leu Thr Gln Lys Ile Asp Lys Glu Glu Leu Ala 
                165                 170                 175     


Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg 
            180                 185                 190         


Gly Glu Glu Glu Glu Glu Asn Thr Asn Lys Leu Val Glu Phe Tyr Ser 
        195                 200                 205             


Leu Lys Ile Ile Asp Val Ile Ala Asp Asn Glu Val Asn Lys Lys Gly 
    210                 215                 220                 


Glu Val Trp Tyr Ser Leu His Leu Glu Asn Gly Trp Ile Tyr Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Ile Ser Leu Val Asp Trp Lys Asp Lys Val Arg Asp Phe 
                245                 250                 255     


Ile Val Thr Thr Asp Val Asn Asp Asp Gly Ser Glu Lys Leu Asp Lys 
            260                 265                 270         


Asp Gly Val Val Lys Arg Ser Phe Arg Ala Pro Ser Ala Asp Asp Trp 
        275                 280                 285             


Thr Leu Leu Lys Lys Lys Thr Glu Gln Asp Ile Asp Asn Ser Asn Lys 
    290                 295                 300                 


Thr Val Gly Ala Tyr Ile Tyr Glu Asn Leu Leu Leu Asn Pro Lys Gln 
305                 310                 315                 320 


Lys Ile Lys Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Phe Tyr Lys 
                325                 330                 335     


Asp Glu Leu Lys Gln Ile Leu Glu Lys Gln Lys Glu Phe His Gln Glu 
            340                 345                 350         


Leu Gln Asn Glu Gln Leu Leu Gln Asp Cys Val Arg Glu Leu Tyr Lys 
        355                 360                 365             


Tyr Asn Glu Gln His Gln Gln Met Leu Glu Ser Lys Asp Phe Val His 
    370                 375                 380                 


Leu Phe Leu Asn Asp Ile Ile Phe Tyr Gln Arg Pro Leu Arg Ser Gln 
385                 390                 395                 400 


Lys Ser Leu Ile Ser Asn Cys Thr Leu Glu Lys Arg Val Ser Arg Asp 
                405                 410                 415     


Gly Val Val Phe Pro Ile Lys Val Ile Ser Lys Ser Asn Pro Tyr Tyr 
            420                 425                 430         


Gln Glu Phe Arg Leu Leu Gln Trp Leu Gln Asn Leu Ala Ile Tyr Arg 
        435                 440                 445             


Lys Asp Asp Asp Val Asn Val Thr Gln Glu Phe Leu Asn Ser Ile Glu 
    450                 455                 460                 


Ser Trp Glu Asn Leu Leu Gln Phe Leu Asn Ala Lys Lys Glu Ile Lys 
465                 470                 475                 480 


Gln Glu Gln Leu Ile Lys Phe Leu Leu Glu Gln Lys Gly Leu Lys Gly 
                485                 490                 495     


Asn Ser Leu Lys Thr Ala Ile Leu Thr Tyr Arg Trp Asn Tyr Val Thr 
            500                 505                 510         


Asp Lys Val Tyr Pro Met Asn Glu Thr Arg Ser Leu Ile Gln Asp Lys 
        515                 520                 525             


Leu Lys Lys Val Glu Asn Val Ala Thr Asp Phe Leu Ser Phe Asp Asn 
    530                 535                 540                 


Glu Met Ala Leu Trp His Ile Ile Tyr Ser Val Asn Asp Lys Ile Glu 
545                 550                 555                 560 


Tyr Glu Lys Ala Leu Ala Lys Phe Ala Ser Lys His Asn Leu Asp Glu 
                565                 570                 575     


Ile Ser Phe Val Glu Ser Phe Lys Lys Phe Pro Pro Phe Lys Ser Asp 
            580                 585                 590         


Tyr Gly Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro Leu Met 
        595                 600                 605             


Arg Phe Gly Ser Val Trp Asn Lys Asn Asn Ile Val Pro Ser Val Leu 
    610                 615                 620                 


Asp Arg Ile Asp Lys Ile Leu Thr Gly Glu Tyr Asp Glu Lys Ile Lys 
625                 630                 635                 640 


Ile Arg Val Arg Glu Lys Ala Glu Gln Phe Gln Leu Asn Gln Ile Glu 
                645                 650                 655     


Asp Phe Gln Asn Leu Pro Leu Trp Leu Ala Gln Tyr Val Val Tyr Asp 
            660                 665                 670         


Arg His Ser Glu Ala Glu Ile Ala Gly Lys Trp Asn Ser Val Lys Asp 
        675                 680                 685             


Leu Glu Asn Tyr Leu Lys Glu Phe Lys Gln His Ser Leu Arg Asn Pro 
    690                 695                 700                 


Ile Val Glu Gln Ile Ile Thr Glu Thr Leu Arg Val Val Lys Asp Ile 
705                 710                 715                 720 


Trp Gln Gln Tyr Gly Asn Gly Val Gln Asn Phe Phe Asp Glu Ile His 
                725                 730                 735     


Ile Glu Leu Gly Arg Glu Met Lys Asn Thr Ala Asp Glu Arg Lys Arg 
            740                 745                 750         


Ile Thr Asn Ser Val Thr Glu Asn Glu Asn Thr Asn Leu Arg Ile Lys 
        755                 760                 765             


Ala Leu Leu Val Glu Leu Lys Glu Asp Thr Asn Ile Glu Asn Val Arg 
    770                 775                 780                 


Pro His Ser Pro Met Gln Gln Glu Ile Leu Lys Ile Tyr Glu Glu Gly 
785                 790                 795                 800 


Val Leu Asn Ala Val Glu Asn Ile Asp Glu Asp Ile Leu Lys Ile Ser 
                805                 810                 815     


Lys Thr Ala Gln Pro Ser Lys Ser Glu Leu Ile Arg Tyr Lys Leu Trp 
            820                 825                 830         


Leu Glu Gln Lys Tyr Gln Ser Pro Tyr Thr Gly Glu Met Ile Pro Leu 
        835                 840                 845             


Ser Arg Leu Phe Thr Ser Asp Tyr Glu Ile Glu His Val Ile Pro Gln 
    850                 855                 860                 


Ser Arg Tyr Phe Asp Asp Ser Leu Ser Asn Lys Val Ile Cys Glu Ala 
865                 870                 875                 880 


Ala Val Asn Lys Arg Lys Asp Asn Gln Leu Gly Leu Glu Phe Ile Lys 
                885                 890                 895     


Asn His His Ser Glu Lys Ile Glu Leu Gly Asn Gly Arg Thr Ala Gln 
            900                 905                 910         


Val Leu Glu Val Glu Ala Tyr Glu Ser Phe Val Lys Lys Asn Tyr Asp 
        915                 920                 925             


Lys Asn Arg Gly Lys Arg Asn Lys Leu Leu Leu Glu Asp Val Pro Glu 
    930                 935                 940                 


Lys Met Ile Glu Arg Gln Leu Asn Asp Thr Arg Tyr Ile Ser Lys Phe 
945                 950                 955                 960 


Val Thr His Leu Leu Ser Asn Ile Val Arg Lys Asp Glu Val Asn Ser 
                965                 970                 975     


Lys Asp Asp Gly Ile Asn Ser Lys Asn Ile Ile Pro Gly Asn Gly Lys 
            980                 985                 990         


Ile Thr Ser Gln Leu Lys Gln Asp  Trp Gly Leu Asn Asp  Val Trp Asn 
        995                 1000                 1005             


Glu Leu  Ile Leu Pro Arg Phe  Glu Arg Met Asn Asn  Leu Thr Asn 
    1010                 1015                 1020             


Ser Thr  Asp Phe Thr Ser Thr  Asn Thr Asn Gly Lys  Ile Ile Pro 
    1025                 1030                 1035             


Thr Val  Pro Leu Glu Tyr Ser  Lys Gly Phe Ser Lys  Lys Arg Ile 
    1040                 1045                 1050             


Asp His  Arg His His Ala Leu  Asp Ala Leu Val Ile  Ala Leu Ala 
    1055                 1060                 1065             


Thr Arg  Asp His Val Asn Leu  Leu Asn Asn Glu Ser  Ala Leu Pro 
    1070                 1075                 1080             


Lys Lys  Asp Arg Thr Lys Glu  Glu Gln Lys Ser Phe  Arg Phe Asp 
    1085                 1090                 1095             


Leu Gln  Val Asn Leu Arg Asn  Lys Glu Lys Tyr Phe  Asn Val Lys 
    1100                 1105                 1110             


Glu Gly  Arg Glu Lys Glu Lys  Phe Thr Thr Phe Lys  Lys Pro Trp 
    1115                 1120                 1125             


Asn Thr  Leu Thr Gln Asp Thr  Arg Asp Ala Leu Glu  Asn Met Val 
    1130                 1135                 1140             


Val Ser  Phe Lys Gln Asn Leu  Arg Val Ile Asn Lys  Ala Thr Asn 
    1145                 1150                 1155             


Tyr Tyr  Glu Ser Tyr Thr Asp  Glu Asn Gly Asn Leu  Arg Leu Asp 
    1160                 1165                 1170             


Lys Tyr  Gly Asn Pro Lys Lys  Glu Leu Ile Ser Gln  Lys Gly Thr 
    1175                 1180                 1185             


Asn Trp  Ala Ile Arg Lys Ser  Leu His Lys Glu Thr  Val Ser Gly 
    1190                 1195                 1200             


Gln Ile  His Leu Asp Arg Val  Lys Val Thr Lys Gly  Lys Ile Val 
    1205                 1210                 1215             


Thr Ala  Thr Arg Lys Ser Leu  Asp Ser Ser Phe Asn  Glu Lys Ser 
    1220                 1225                 1230             


Ile Glu  Ser Ile Thr Asp Thr  Gly Ile Gln Lys Ile  Leu Arg Asn 
    1235                 1240                 1245             


Tyr Leu  Lys Ala Lys Asp Asn  Lys Pro Asp Val Ala  Phe Ser Pro 
    1250                 1255                 1260             


Glu Gly  Ile Glu Glu Leu Asn  Lys Ser Ile Ser Val  Tyr Asn Glu 
    1265                 1270                 1275             


Gly Lys  Asn His Gln Pro Ile  Ile Lys Val Arg Ile  Phe Glu Gln 
    1280                 1285                 1290             


Gly Ser  Lys Phe Pro Val Gly  Glu Thr Gly Asn Lys  Ile Ala Lys 
    1295                 1300                 1305             


Phe Val  Glu Ala Ala Lys Gly  Thr Asn Leu Phe Phe  Gly Ile Tyr 
    1310                 1315                 1320             


Gln Asp  Lys Thr Gly Lys Arg  Ser Tyr Asp Thr Ile  Pro Leu Asn 
    1325                 1330                 1335             


Leu Val  Ile Glu Arg Leu Lys  Gln Gly Leu Ser Pro  Val Pro Glu 
    1340                 1345                 1350             


Thr Asn  Glu Lys Gly His Gln  Leu Leu Phe His Leu  Ser Pro Asn 
    1355                 1360                 1365             


Asp Leu  Val Tyr Val Pro Thr  Ile Asp Asp Asn Glu  Gln Leu Asp 
    1370                 1375                 1380             


Ser Asn  Arg Val Tyr Lys Phe  Thr Asp Ser Ser Asp  Thr Thr Cys 
    1385                 1390                 1395             


Asn Phe  Ile Pro Ser Asn Ile  Ser Ala Ile Ile Phe  Asn Ile Asn 
    1400                 1405                 1410             


Ser Lys  Glu Gln Glu Lys Arg  Gly Ile Asn Tyr Pro  Ile Gln Asn 
    1415                 1420                 1425             


Glu Leu  Gly Val Gly Ser Pro  Gln Ser Lys Asn Gln  Lys Ser Phe 
    1430                 1435                 1440             


Asp Gly  Phe Met Ile Lys Glu  Val Cys Ile Lys Leu  Lys Val Asp 
    1445                 1450                 1455             


Arg Leu  Gly Asn Ile Ser Lys  Thr 
    1460                 1465     


<210> 341
<211> 1077
<212> PRT
<213> Neisseria bacilliformis


<220>
<223> Neisseria bacilliformis ATCC BAA-1200

<400> 341
Met Gln Gln Lys Pro Gln Arg Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Cys Val Trp Ala Asp Glu Asn Glu His Pro 
            20                  25                  30          


Thr Gly Leu Leu Asp Cys Gly Val Arg Thr Phe Glu Arg Ala Glu Val 
        35                  40                  45              


Pro Lys Thr Gly Asp Ser Leu Ala Leu Ala Arg Arg Gln Ala Arg Ser 
    50                  55                  60                  


Val Arg Arg Leu Ile Arg Arg Arg Ala His Arg Leu Leu Arg Leu Arg 
65                  70                  75                  80  


Arg Leu Leu Lys Arg Glu Gly Val Leu Leu Ser Ala Asp Phe Asn Glu 
                85                  90                  95      


Asn Gly Leu Val Arg Gly Leu Pro Ile Asp Ala Trp Ala Leu Arg Val 
            100                 105                 110         


Ala Gly Leu Asp Arg Lys Leu Ser Asn Lys Glu Trp Ala Ala Val Leu 
        115                 120                 125             


Leu His Leu Val Lys His Arg Gly Tyr Leu Ser Gln Arg Lys Asn Glu 
    130                 135                 140                 


Thr Gln Ser Lys Asp Lys Glu Leu Gly Arg Leu Leu Ala Gly Val Asn 
145                 150                 155                 160 


Gly Asn Arg Glu Ala Leu Gln Asn Arg Ser Asp Glu Tyr Arg Thr Ala 
                165                 170                 175     


Ala Glu Leu Ala Val Lys Lys Phe Ala Ala Glu Asn Asn Gly Ser Leu 
            180                 185                 190         


Arg Asn Lys Gly Gly Asp Tyr Ser His Thr Phe Asp Arg Lys Asp Leu 
        195                 200                 205             


Gln Arg Glu Leu His Leu Leu Phe Glu Arg Gln Arg Ala Leu Asp Asn 
    210                 215                 220                 


Pro Phe Thr Ser Ser Glu Met Glu Ala Ala Val Asp Glu Leu Leu Met 
225                 230                 235                 240 


Lys Gln Arg Ser Ala Leu Gln Gly Glu Ala Val Leu Lys Met Leu Gly 
                245                 250                 255     


Arg Cys Thr Phe Glu Pro Ser Glu Tyr Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Ser Ala Glu Arg Phe Val Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Gln Tyr Asn Gly Glu Glu Arg Ala Leu Ser Glu Ala Glu Arg Arg Leu 
    290                 295                 300                 


Leu Leu Asp Glu Pro Tyr Gln Lys Ala Lys Leu Thr Tyr Lys Gln Val 
305                 310                 315                 320 


Arg Thr Ile Leu Glu Leu Pro Glu Ser Ala Val Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly His Gly Glu Asp Gly Leu Lys Ala Glu Ser Gly Thr Leu Met 
            340                 345                 350         


Glu Met Lys Ala Tyr His Ala Val Arg Lys Ala Leu Lys Asp Ala Gly 
        355                 360                 365             


Leu Glu Gly Glu Trp Glu Asn Arg Ile Arg Asn Pro Glu Leu Leu Asp 
    370                 375                 380                 


Ala Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp Glu Asp Ile Arg 
385                 390                 395                 400 


Ala Asn Leu Ala Ala Phe Arg Leu Ser Glu Asn Val Leu Glu Ala Leu 
                405                 410                 415     


Leu Ala Gly Leu Asn Phe Asp Lys Phe Val His Leu Ser Leu Lys Ala 
            420                 425                 430         


Leu Ala Lys Ile Leu Pro Leu Met Glu Gln Gly Met Arg Tyr Asp Glu 
        435                 440                 445             


Ala Cys Lys Glu Ala Tyr Gly Asp His Tyr Gly Ala Lys Glu Gln Glu 
    450                 455                 460                 


Asp His Arg Leu Leu Pro Pro Phe Val Ala Asp Asp Ile Arg Asn Pro 
465                 470                 475                 480 


Val Val Phe Arg Thr Leu Thr Gln Ala Arg Lys Ile Val Asn Glu Ile 
                485                 490                 495     


Val Arg Arg Tyr Gly Ser Pro Leu Arg Val His Ile Glu Thr Gly Arg 
            500                 505                 510         


Glu Val Gly Lys Ser Phe Ser Asp Arg Lys Glu Ile Glu Lys Arg Gln 
        515                 520                 525             


Glu Glu Asn Arg Lys Glu Arg Glu Arg Ala Ala Ala His Phe Lys Glu 
    530                 535                 540                 


Leu Phe Pro Asn Phe Ala Gly Glu Pro Lys Ala Gln Asp Ile Leu Lys 
545                 550                 555                 560 


Leu Arg Leu Tyr Glu Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys 
                565                 570                 575     


Glu Ile Asp Leu Arg Arg Leu Pro Glu Lys Gly Tyr Val Glu Ile Asp 
            580                 585                 590         


His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys 
        595                 600                 605             


Val Leu Val Leu Gly Lys Glu Asn Gln Asp Lys Arg Asn Arg Thr Pro 
    610                 615                 620                 


Tyr Glu Tyr Leu Asp Gly Lys Gly Asn Ser Gly Ala Trp Arg Ala Phe 
625                 630                 635                 640 


Ala Glu Arg Val Ser Gly Cys Arg Phe Pro Tyr Ala Lys Lys Gln Arg 
                645                 650                 655     


Leu Leu Thr Gln Lys Leu Asp Glu Lys Thr Glu Gln Gly Phe Leu Glu 
            660                 665                 670         


Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys Gln Phe 
        675                 680                 685             


Ile Glu Glu Lys Met His Leu Glu Gly Ala Gly Lys Lys Arg Val Phe 
    690                 695                 700                 


Ala Ser Asn Gly Gln Ile Thr Ala Leu Leu Arg Gly Phe Trp Gly Leu 
705                 710                 715                 720 


Lys Lys Val Arg Glu Glu Asn Asp Arg His His Ala Leu Asp Ala Val 
                725                 730                 735     


Val Val Ala Cys Ser Ser Val Ser Met Gln Gln Lys Ile Thr Arg His 
            740                 745                 750         


Phe Arg Tyr Arg Glu Glu Leu Glu His Ile Asp Arg Glu Thr Gly Glu 
        755                 760                 765             


Val Ile His Gly Phe Pro Gln Pro Trp Glu Phe Phe Arg Gln Glu Val 
    770                 775                 780                 


Met Thr Arg Val Phe Ser Asp Asp Pro Val Ser Glu Leu Ala Glu Lys 
785                 790                 795                 800 


Leu Asp Ser Arg Pro Glu Ala Val His Glu Phe Val Thr Pro Leu Phe 
                805                 810                 815     


Val Ser Arg Ala Pro His Arg Lys Val Thr Gly Gln Gly His Leu Glu 
            820                 825                 830         


Thr Ile Arg Ser Ala Lys Arg Leu Asp Glu Lys Ile Ser Val Val Lys 
        835                 840                 845             


Leu Pro Leu Thr Gln Leu Lys Thr Lys Asp Ile Glu Arg Ile Val Gly 
    850                 855                 860                 


Tyr Pro Asn Arg Glu Pro Ala Leu Tyr Asp Ala Leu Ala Ala Arg Leu 
865                 870                 875                 880 


Ala Ala Phe Lys Asp Asp Pro Ala Lys Ala Phe Ser Glu Pro Phe Tyr 
                885                 890                 895     


Lys Thr Gly Lys Asp Gly Lys Cys Gly Val Leu Val Lys Ala Val Arg 
            900                 905                 910         


Val Glu Asn Val Gln Lys Ser Gly Leu Leu Val Arg Lys Asp Glu Ser 
        915                 920                 925             


Gly Lys Met Gln Gly Val Ala Asp Asn Ala Thr Met Val Arg Val Asp 
    930                 935                 940                 


Val Phe Gly Lys Asn Gly Lys Asn Tyr Leu Val Pro Val Tyr Ala Trp 
945                 950                 955                 960 


Gln Val Glu Lys Gly Glu Leu Pro Asn Arg Ala Val Val Ala Tyr Ala 
                965                 970                 975     


Asp Glu Glu Asp Trp Asp Glu Met Asp Asp Ser Phe Glu Phe Lys Phe 
            980                 985                 990         


Ser Leu Tyr Pro Asn Asp Leu Val  Glu Val Val Thr Lys  Lys Asp Lys 
        995                 1000                 1005             


Phe Phe  Gly Tyr Tyr Ser Gly  Phe Asn Arg Ala Thr  Gly Ala Ile 
    1010                 1015                 1020             


Asn Ile  Lys Glu His Asp Leu  Ser Lys Ser Lys Val  Lys Asn Gly 
    1025                 1030                 1035             


Val Tyr  Glu Gly Ile Gly Val  Lys Thr Ala Gln Ser  Phe Gln Lys 
    1040                 1045                 1050             


Tyr Gln  Val Asp Thr Leu Gly  Lys Thr Ile Arg Leu  Cys Lys Pro 
    1055                 1060                 1065             


Glu Lys  Arg Met Gly Phe Lys  Lys Lys 
    1070                 1075         


<210> 342
<211> 1082
<212> PRT
<213> Neisseria cinerea


<220>
<223> Neisseria cinerea ATCC 14685

<400> 342
Met Ala Ala Phe Lys Pro Asn Pro Met Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Ile Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Ala Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Thr His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Asn Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Asn Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Asp Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Thr Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Val Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Asp Leu Asp Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Asn Arg Tyr Asp Glu Ala Cys Thr Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ser Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Ala Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Ile Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Met Leu Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Ile Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Ala His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Lys Tyr Val Thr Pro Leu Phe Ile Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Ile Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val His Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Ile Val Arg Val Asp Val Phe Glu Lys Gly Gly Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Thr Val Met Asp 
            980                 985                 990         


Asp Ser Phe Glu Phe Lys Phe Val  Leu Tyr Ala Asn Asp  Leu Ile Lys 
        995                 1000                 1005             


Leu Thr  Ala Lys Lys Asn Glu  Phe Leu Gly Tyr Phe  Val Ser Leu 
    1010                 1015                 1020             


Asn Arg  Ala Thr Gly Ala Ile  Asp Ile Arg Thr His  Asp Thr Asp 
    1025                 1030                 1035             


Ser Thr  Lys Gly Lys Asn Gly  Ile Phe Gln Ser Val  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 343
<211> 1081
<212> PRT
<213> Neisseria flavescens


<220>
<223> Neisseria flavescens SK114

<400> 343
Met Thr Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Ala Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Val Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Val Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Ile Ser Asp Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Ala Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


Tyr Cys Thr Phe Glu Pro Thr Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Ile Asp Met Pro Tyr Lys Asn Lys Leu Thr Tyr Ala Lys Ala Arg 
305                 310                 315                 320 


Glu Leu Leu Gly Leu Asp Asp Thr Ala Phe Phe Lys Gly Leu Arg Tyr 
                325                 330                 335     


Gly Lys Asp Asn Ala Glu Ser Ala Thr Leu Met Glu Met Lys Ala Tyr 
            340                 345                 350         


His Ala Ile Arg Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys Lys 
        355                 360                 365             


Ser Pro Leu Ser Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr Ala 
    370                 375                 380                 


Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys Gly 
385                 390                 395                 400 


Cys Leu Gln Pro Glu Ile Leu Asp Ala Leu Leu Lys His Ile Asn Phe 
                405                 410                 415     


Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val Pro 
            420                 425                 430         


Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Thr Tyr 
        435                 440                 445             


Gly Asp His Tyr Gly Glu Lys Asn Ser Glu Glu Met Leu Tyr Leu Pro 
    450                 455                 460                 


Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala Leu 
465                 470                 475                 480 


Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly Ser 
                485                 490                 495     


Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser Phe 
            500                 505                 510         


Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys Asp 
        515                 520                 525             


Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe Val 
    530                 535                 540                 


Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu Gln 
545                 550                 555                 560 


Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Ala Ile Asp Ile Arg Arg 
                565                 570                 575     


Leu Asn Gly Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe Ser 
            580                 585                 590         


Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly Ser 
        595                 600                 605             


Glu Asn Gln Asn Lys Gly Asn Arg Thr Pro Tyr Glu Tyr Leu Asn Gly 
    610                 615                 620                 


Lys Asp Asn Ser Arg Glu Trp Leu Glu Phe Lys Ala Arg Val Glu Thr 
625                 630                 635                 640 


Ser Arg Phe Pro His Ser Lys Lys Gln Arg Val Leu Leu Gln Lys Phe 
                645                 650                 655     


Asp Glu Lys Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr Val 
            660                 665                 670         


Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Met Gln Leu Thr Gly 
        675                 680                 685             


Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn Leu 
    690                 695                 700                 


Leu Arg Gly Phe Trp Gly Leu His Lys Val Arg Ala Glu Asn Asp Arg 
705                 710                 715                 720 


His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala Met 
                725                 730                 735     


Gln Gln Lys Ile Thr Cys Phe Val Arg Tyr Lys Glu Met Asn Ala Phe 
            740                 745                 750         


Asp Gly Lys Thr Val Asp Lys Glu Thr Gly Glu Val Leu His Gln Lys 
        755                 760                 765             


Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met Ile 
    770                 775                 780                 


Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala Asp 
785                 790                 795                 800 


Thr Pro Glu Lys Leu Arg Ala Leu Leu Ala Glu Lys Leu Ser Ser Arg 
                805                 810                 815     


Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg Ala 
            820                 825                 830         


Pro Asn Arg Lys Met Ser Gly Ala His Lys Asp Thr Leu Arg Ser Ala 
        835                 840                 845             


Lys Arg Phe Val Lys His Asn Glu Lys Ile Ser Val Lys Arg Val Trp 
    850                 855                 860                 


Leu Thr Glu Ile Lys Leu Ala Asp Leu Glu Asn Met Val Asn Tyr Lys 
865                 870                 875                 880 


Asn Gly Arg Glu Ile Glu Leu Tyr Glu Ala Leu Lys Ala Arg Leu Gly 
                885                 890                 895     


Ala Tyr Gly Gly Asn Ala Lys Gln Ala Phe Asp Pro Lys Asp Asn Pro 
            900                 905                 910         


Phe Tyr Lys Lys Gly Gly Gln Leu Val Lys Ala Val Arg Val Glu Lys 
        915                 920                 925             


Thr Gln Glu Ser Gly Val Leu Leu Asn Lys Lys Asn Ala Tyr Thr Ile 
    930                 935                 940                 


Ala Asp Asn Gly Asp Met Val Arg Val Asp Val Phe Cys Lys Val Asp 
945                 950                 955                 960 


Lys Lys Gly Lys Asn Gln Tyr Phe Ile Val Pro Ile Tyr Ala Trp Gln 
                965                 970                 975     


Val Ala Glu Asn Ile Leu Pro Asp Ile Asp Cys Lys Gly Tyr Arg Ile 
            980                 985                 990         


Asp Asp Ser Tyr Thr Phe Cys Phe  Ser Leu His Lys Tyr  Asp Leu Ile 
        995                 1000                 1005             


Ala Phe  Gln Lys Asp Glu Lys  Ser Lys Val Glu Phe  Ala Tyr Tyr 
    1010                 1015                 1020             


Ile Asn  Cys Asp Ser Ser Asn  Gly Arg Phe Tyr Leu  Ala Trp His 
    1025                 1030                 1035             


Asp Lys  Gly Ser Lys Glu Gln  Gln Phe Arg Ile Ser  Thr Gln Asn 
    1040                 1045                 1050             


Leu Val  Leu Met Gln Lys Tyr  Gln Ile Asp Glu Leu  Gly Lys Glu 
    1055                 1060                 1065             


Ile Arg  Pro Cys Arg Leu Lys  Lys Arg Pro Pro Val  Arg 
    1070                 1075                 1080     


<210> 344
<211> 1082
<212> PRT
<213> Neisseria lactamica

<400> 344
Met Ala Ala Phe Lys Pro Asn Pro Met Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Lys Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Asp Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Val Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Cys Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Asn Leu Leu Phe Glu Lys Gln Lys Glu Phe Ser Asn 
    210                 215                 220                 


Pro His Val Ser Asp Ser Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Ala Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Pro Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Thr Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Lys Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Cys Lys Lys Asn Ala Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Cys Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Glu Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Ile Leu Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Ala His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Ile Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Gly Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Asp Ala Leu Lys Ala Gln Leu Glu Thr His Lys 
                885                 890                 895     


Asp Asn Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Ile Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Gly Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Ala Phe Lys Asp Glu Glu Asp Trp Thr Val Met Asp 
            980                 985                 990         


Asp Ser Phe Glu Phe Arg Phe Val  Leu Tyr Ala Asn Asp  Leu Ile Lys 
        995                 1000                 1005             


Leu Thr  Ala Lys Lys Asn Glu  Phe Leu Gly Tyr Phe  Val Ser Leu 
    1010                 1015                 1020             


Asn Arg  Ala Thr Gly Ala Ile  Asp Ile Arg Thr His  Asp Thr Asp 
    1025                 1030                 1035             


Ser Thr  Lys Gly Lys Asn Gly  Ile Phe Gln Ser Val  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Asn Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 345
<211> 1082
<212> PRT
<213> Neisseria meningitidis

<400> 345
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Asn Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Ile Ser Asp Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Thr Thr 
    290                 295                 300                 


Leu Ile Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Glu Leu Asp Asn Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Asp Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Thr Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Glu Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Met Leu Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 346
<211> 1082
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis 2007056

<400> 346
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Glu 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 347
<211> 1082
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis 63049

<400> 347
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Ser Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Val Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Arg Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Ala Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 348
<211> 1082
<212> PRT
<213> Neisseria meningitidis

<400> 348
Met Ala Ala Phe Lys Pro Asn Ser Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asn 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Gly Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Ser Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Leu Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 349
<211> 1082
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis 92045

<400> 349
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Cys Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Asn Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Glu Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Ile Leu Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Gly Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 350
<211> 1081
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis 93003

<400> 350
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Glu Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Thr Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Ala Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Glu Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu His Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Ile Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Ala His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Ile Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Ala Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Ala Gly Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Ala Tyr Ala Asp Glu Glu Asp Trp Thr Val Ile Asp 
            980                 985                 990         


Glu Ser Phe Arg Phe Lys Phe Val  Leu Tyr Ser Asn Asp  Leu Ile Lys 
        995                 1000                 1005             


Val Gln  Leu Lys Lys Asp Ser  Phe Leu Gly Tyr Phe  Ser Gly Leu 
    1010                 1015                 1020             


Asp Arg  Ala Thr Gly Ala Ile  Ser Leu Arg Glu His  Asp Leu Glu 
    1025                 1030                 1035             


Lys Ser  Lys Gly Lys Asp Gly  Met His Arg Ile Gly  Val Lys Thr 
    1040                 1045                 1050             


Ala Leu  Ser Phe Gln Lys Tyr  Gln Ile Asp Glu Met  Gly Lys Glu 
    1055                 1060                 1065             


Ile Arg  Pro Cys Arg Leu Lys  Lys Arg Pro Pro Val  Arg 
    1070                 1075                 1080     


<210> 351
<211> 1081
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis 93004

<400> 351
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Lys Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Asn Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Ile Ser Asp Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Thr Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Val Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Gln Pro Leu Thr Asp Thr Gln Arg Ala Lys 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asn Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Gln Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Ala Tyr Ala Asp Glu Glu Asp Trp Thr Val Ile Asp 
            980                 985                 990         


Glu Ser Phe Arg Phe Lys Phe Val  Leu Tyr Ser Asn Asp  Leu Ile Lys 
        995                 1000                 1005             


Val Gln  Leu Lys Lys Asp Ser  Phe Leu Gly Tyr Phe  Ser Gly Leu 
    1010                 1015                 1020             


Asp Arg  Ala Thr Gly Ala Ile  Ser Leu Arg Glu His  Asp Leu Glu 
    1025                 1030                 1035             


Lys Ser  Lys Gly Lys Asp Gly  Met His Arg Ile Gly  Val Lys Thr 
    1040                 1045                 1050             


Ala Leu  Ser Phe Gln Lys Tyr  Gln Ile Asp Glu Met  Gly Lys Glu 
    1055                 1060                 1065             


Ile Arg  Pro Cys Arg Leu Lys  Lys Arg Pro Pro Val  Arg 
    1070                 1075                 1080     


<210> 352
<211> 1082
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis 96023

<400> 352
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Ser Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Tyr Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 353
<211> 1081
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis 98008

<400> 353
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Ala Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ser Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asn Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Ala Gly Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Ala Tyr Ala Asp Glu Glu Gly Trp Thr Val Ile Asp 
            980                 985                 990         


Glu Ser Phe Arg Phe Lys Phe Val  Leu Tyr Ser Asn Asp  Leu Ile Lys 
        995                 1000                 1005             


Val Gln  Leu Lys Lys Asp Ser  Phe Leu Gly Tyr Phe  Ser Gly Leu 
    1010                 1015                 1020             


Asp Arg  Ala Thr Gly Ala Ile  Ser Leu Arg Glu His  Asp Leu Glu 
    1025                 1030                 1035             


Lys Ser  Lys Gly Lys Asp Gly  Met His Arg Ile Gly  Val Lys Thr 
    1040                 1045                 1050             


Ala Leu  Ser Phe Gln Lys Tyr  Gln Ile Asp Glu Met  Gly Lys Glu 
    1055                 1060                 1065             


Ile Arg  Leu Cys Arg Leu Lys  Lys Arg Pro Pro Val  Arg 
    1070                 1075                 1080     


<210> 354
<211> 1082
<212> PRT
<213> Neisseria meningitidis

<400> 354
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Val Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Ile Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 355
<211> 1082
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis alpha275

<400> 355
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Ala Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 356
<211> 1082
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis ATCC 13091

<400> 356
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asn 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Leu Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Gly Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Asn Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Ile Ser Asp Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Thr Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Thr Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Glu Leu Asp Asp Ile Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Asn 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Asp Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile His Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Thr Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Ile Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Met Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 357
<211> 1081
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis N1568

<400> 357
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Cys Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Asn Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Ser Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Thr Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Ala Tyr Ala Asp Glu Glu Asp Trp Thr Val Ile Asp 
            980                 985                 990         


Glu Ser Phe Arg Phe Lys Phe Val  Leu Tyr Ser Asn Asp  Leu Ile Lys 
        995                 1000                 1005             


Val Gln  Leu Lys Lys Asp Ser  Phe Leu Gly Tyr Phe  Ser Gly Leu 
    1010                 1015                 1020             


Asp Arg  Ala Thr Gly Ala Ile  Ser Leu Arg Glu His  Asp Leu Glu 
    1025                 1030                 1035             


Lys Ser  Lys Gly Lys Asp Gly  Met His Arg Ile Gly  Val Lys Thr 
    1040                 1045                 1050             


Ala Leu  Ser Phe Gln Lys Tyr  Gln Ile Asp Glu Met  Gly Lys Glu 
    1055                 1060                 1065             


Ile Arg  Pro Cys Arg Leu Lys  Lys Arg Pro Pro Val  Arg 
    1070                 1075                 1080     


<210> 358
<211> 1081
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis NM140

<400> 358
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Ala Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ser Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Arg Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Asp Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Ile Ser Asp Asp Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Thr Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Val Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Glu Leu Asp Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Val Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Asp Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Ala Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Glu Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Met Leu Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asn 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Ala Gly Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Ala Tyr Ala Asp Glu Glu Gly Trp Thr Val Ile Asp 
            980                 985                 990         


Glu Ser Phe Arg Phe Lys Phe Val  Leu Tyr Ser Asn Asp  Leu Ile Lys 
        995                 1000                 1005             


Val Gln  Leu Lys Lys Asp Ser  Phe Leu Gly Tyr Phe  Ser Gly Leu 
    1010                 1015                 1020             


Asp Arg  Ala Thr Gly Ala Ile  Ser Leu Arg Glu His  Asp Leu Glu 
    1025                 1030                 1035             


Lys Ser  Lys Gly Lys Asp Gly  Met His Arg Ile Gly  Val Lys Thr 
    1040                 1045                 1050             


Ala Leu  Ser Phe Gln Lys Tyr  Gln Ile Asp Glu Met  Gly Lys Glu 
    1055                 1060                 1065             


Ile Arg  Leu Cys Arg Leu Lys  Lys Arg Pro Pro Val  Arg 
    1070                 1075                 1080     


<210> 359
<211> 1082
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis NM220

<400> 359
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asn Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Ser Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Cys Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Ile Leu Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Lys Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Ala His Lys Asp Thr Leu Arg Ser 
        835                 840                 845             


Ala Lys Arg Phe Val Lys His Asn Glu Lys Ile Ser Val Lys Arg Val 
    850                 855                 860                 


Trp Leu Thr Glu Ile Lys Leu Ala Asp Leu Glu Asn Met Val Asn Tyr 
865                 870                 875                 880 


Lys Asn Gly Arg Glu Ile Glu Leu Tyr Glu Ala Leu Lys Ala Arg Leu 
                885                 890                 895     


Glu Ala Tyr Gly Gly Asn Ala Lys Gln Ala Phe Asp Pro Lys Asp Asn 
            900                 905                 910         


Pro Phe Tyr Lys Lys Gly Gly Gln Leu Val Lys Ala Val Arg Val Glu 
        915                 920                 925             


Lys Thr Gln Glu Ser Gly Val Leu Leu Asn Lys Lys Asn Ala Tyr Thr 
    930                 935                 940                 


Ile Ala Asp Asn Gly Asp Met Val Arg Val Asp Val Phe Cys Lys Val 
945                 950                 955                 960 


Asp Lys Lys Gly Lys Asn Gln Tyr Phe Ile Val Pro Ile Tyr Ala Trp 
                965                 970                 975     


Gln Val Ala Glu Asn Ile Leu Pro Asp Ile Asp Cys Lys Gly Tyr Arg 
            980                 985                 990         


Ile Asp Asp Ser Tyr Thr Phe Cys  Phe Ser Leu His Lys  Tyr Asp Leu 
        995                 1000                 1005             


Ile Ala  Phe Gln Lys Asp Glu  Lys Ser Lys Val Glu  Phe Ala Tyr 
    1010                 1015                 1020             


Tyr Ile  Asn Cys Asp Ser Ser  Asn Gly Arg Phe Tyr  Leu Ala Trp 
    1025                 1030                 1035             


His Asp  Lys Gly Ser Lys Glu  Gln Gln Phe Arg Ile  Ser Thr Gln 
    1040                 1045                 1050             


Asn Leu  Val Leu Ile Gln Lys  Tyr Gln Val Asn Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 360
<211> 1082
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis NM233

<400> 360
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asn Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Ser Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Lys Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Cys Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Ile Leu Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Lys Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Ala His Lys Asp Thr Leu Arg Ser 
        835                 840                 845             


Ala Lys Arg Phe Val Lys His Asn Glu Lys Ile Ser Val Lys Arg Val 
    850                 855                 860                 


Trp Leu Thr Glu Ile Lys Leu Ala Asp Leu Glu Asn Met Val Asn Tyr 
865                 870                 875                 880 


Lys Asn Gly Arg Glu Ile Glu Leu Tyr Glu Ala Leu Lys Ala Arg Leu 
                885                 890                 895     


Glu Ala Tyr Gly Gly Asn Ala Lys Gln Ala Phe Asp Pro Lys Asp Asn 
            900                 905                 910         


Pro Phe Tyr Lys Lys Gly Gly Gln Leu Val Lys Ala Val Arg Val Glu 
        915                 920                 925             


Lys Thr Gln Glu Ser Gly Val Leu Leu Asn Lys Lys Asn Ala Tyr Thr 
    930                 935                 940                 


Ile Ala Asp Asn Gly Asp Met Val Arg Val Asp Val Phe Cys Lys Val 
945                 950                 955                 960 


Asp Lys Lys Gly Lys Asn Gln Tyr Phe Ile Val Pro Ile Tyr Ala Trp 
                965                 970                 975     


Gln Val Ala Glu Asn Ile Leu Pro Asp Ile Asp Cys Lys Gly Tyr Arg 
            980                 985                 990         


Ile Asp Asp Ser Tyr Thr Phe Cys  Phe Ser Leu His Lys  Tyr Asp Leu 
        995                 1000                 1005             


Ile Ala  Phe Gln Lys Asp Glu  Lys Ser Lys Val Glu  Phe Ala Tyr 
    1010                 1015                 1020             


Tyr Ile  Asn Cys Asp Ser Ser  Asn Gly Arg Phe Tyr  Leu Ala Trp 
    1025                 1030                 1035             


His Asp  Lys Gly Ser Lys Glu  Gln Gln Phe Arg Ile  Ser Thr Gln 
    1040                 1045                 1050             


Asn Leu  Val Leu Ile Gln Lys  Tyr Gln Val Asn Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 361
<211> 1082
<212> PRT
<213> Neisseria meningitidis

<400> 361
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Ser Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 362
<211> 1082
<212> PRT
<213> Neisseria meningitidis

<400> 362
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 363
<211> 1089
<212> PRT
<213> Neisseria sp.


<220>
<223> Neisseria sp. oral taxon 014 str. F0314

<400> 363
Met Thr Ala Phe Lys Pro Asn Pro Leu Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Asp Lys 
            20                  25                  30          


Glu Asn Pro Val Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Met Pro Lys Thr Gly Asp Ser Leu Ala Ala Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys His Glu Gly Val Leu Lys Pro Glu Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Val Lys Pro Leu Pro Tyr Ile Pro Lys Gln 
            100                 105                 110         


Pro Arg Asn Thr Pro Trp Gln Leu Arg Ala Ala Ala Leu Asp Arg Lys 
        115                 120                 125             


Leu Thr Pro Leu Glu Trp Ala Ala Val Leu Leu His Leu Val Lys His 
    130                 135                 140                 


Arg Gly Tyr Leu Ser Gln Arg Lys Asn Glu Gly Glu Thr Asp Asp Lys 
145                 150                 155                 160 


Glu Leu Gly Ala Leu Leu Lys Gly Val Ala Asp Asn Thr His Ala Leu 
                165                 170                 175     


Gln Ala Gly Asn Phe Arg Thr Pro Ala Glu Leu Ala Leu Asn Lys Phe 
            180                 185                 190         


Glu Lys Glu Ser Gly His Ile Arg Asn Gln Arg Gly Asp Tyr Ser His 
        195                 200                 205             


Thr Phe Ser Arg Lys Asp Leu Gln Ala Glu Leu Val Leu Leu Phe Glu 
    210                 215                 220                 


Lys Gln Lys Glu Phe Gly Asn Pro Tyr Val Ser Asp Asp Leu Lys Asn 
225                 230                 235                 240 


Gly Ile Glu Asn Leu Leu Met Thr Gln Arg Pro Ala Leu Ser Gly Asp 
                245                 250                 255     


Ala Ile Gln Lys Met Leu Gly His Cys Thr Phe Glu Pro Ala Glu Pro 
            260                 265                 270         


Lys Ala Ala Lys Asn Thr Tyr Thr Ala Glu Arg Phe Ile Trp Leu Thr 
        275                 280                 285             


Lys Leu Asn Asn Leu Arg Ile Leu Asn Gln Gly Asn Glu Arg Pro Leu 
    290                 295                 300                 


Thr Asp Ala Glu Arg Thr Thr Leu Met Asp Glu Pro Tyr Lys Lys Ser 
305                 310                 315                 320 


Lys Leu Thr Tyr Ala Gln Ala Arg Lys Leu Leu Asp Leu Asp Asp Thr 
                325                 330                 335     


Ala Phe Phe Lys Gly Leu Arg Tyr Gly Lys Asp Asn Ala Glu Ser Ala 
            340                 345                 350         


Thr Leu Met Glu Met Lys Ala Tyr His Ala Ile Ser Arg Ala Leu Glu 
        355                 360                 365             


Lys Glu Gly Leu Lys Asp Lys Lys Ser Pro Leu Ser Leu Ser Pro Glu 
    370                 375                 380                 


Leu Gln Asp Glu Ile Gly Thr Ala Phe Ser Leu Phe Lys Thr Asp Glu 
385                 390                 395                 400 


Glu Ile Thr Gly Arg Leu Lys Gly Cys Leu Gln Pro Glu Ile Leu Asp 
                405                 410                 415     


Ala Leu Leu Lys His Ile Ser Phe Asp Lys Phe Val Gln Ile Ser Leu 
            420                 425                 430         


Lys Ala Leu Arg Arg Ile Val Pro Leu Met Glu Gln Gly Lys Arg Tyr 
        435                 440                 445             


Asp Glu Ala Cys Ala Glu Ile Tyr Gly Asp His His Gly Arg Arg Asn 
    450                 455                 460                 


Ser Glu Glu Thr Leu Tyr Leu Pro Pro Ile Pro Ala Asp Glu Ile Arg 
465                 470                 475                 480 


Asn Pro Val Val Leu Arg Ala Leu Ser Gln Ala Arg Lys Val Ile Asn 
                485                 490                 495     


Gly Val Gly Arg Arg Tyr Gly Ser Pro Ala Arg Ile His Ile Glu Thr 
            500                 505                 510         


Ala Arg Glu Val Gly Lys Ser Phe Lys Asp Arg Lys Glu Ile Glu Lys 
        515                 520                 525             


Arg Gln Glu Glu Asn Arg Lys Asp Arg Glu Lys Ala Ala Ala Glu Phe 
    530                 535                 540                 


Gln Glu Tyr Phe Pro Asn Phe Val Gly Glu Pro Lys Ser Lys Asp Ile 
545                 550                 555                 560 


Leu Lys Leu Arg Leu Tyr Arg Gln Gln Asn Cys Lys Cys Leu Tyr Ser 
                565                 570                 575     


Gly Lys Glu Ile Asn Leu Gly Arg Leu Asn Glu Lys Gly Tyr Val Glu 
            580                 585                 590         


Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe Asn 
        595                 600                 605             


Asn Lys Val Leu Val Leu Gly Ser Glu Asn Gln Asn Lys Gly Asn Arg 
    610                 615                 620                 


Thr Pro Tyr Glu Tyr Leu Asn Gly Lys Asp Asn Ser Arg Glu Trp Gln 
625                 630                 635                 640 


Glu Phe Lys Ala Arg Val Glu Thr Ser Arg Phe Pro His Ser Lys Lys 
                645                 650                 655     


Gln Arg Ile Leu Leu Gln Lys Phe Asp Glu Glu Gly Phe Lys Glu Arg 
            660                 665                 670         


Asn Leu Asn Asp Thr Arg Tyr Val Asn Arg Phe Leu Cys Lys Phe Val 
        675                 680                 685             


Ala Asp His Met Gln Leu Thr Gly Lys Gly Lys Arg Arg Val Phe Ala 
    690                 695                 700                 


Ser Asn Gly Gln Ile Thr Asn Leu Leu Arg Gly Phe Trp Gly Leu Arg 
705                 710                 715                 720 


Lys Val Arg Ala Glu Asn Asp Arg His His Ala Leu Asp Ala Val Val 
                725                 730                 735     


Val Ala Cys Ser Thr Val Ala Met Gln Gln Arg Ile Thr Arg Phe Val 
            740                 745                 750         


Arg Tyr Lys Glu Met Asn Ala Phe Asp Gly Lys Thr Val Asp Lys Glu 
        755                 760                 765             


Thr Gly Glu Val Leu His Gln Lys Thr His Phe Pro Gln Pro Trp Glu 
    770                 775                 780                 


Phe Phe Ala Gln Glu Val Met Ile Arg Val Phe Gly Lys Pro Asp Gly 
785                 790                 795                 800 


Lys Pro Glu Leu Glu Glu Ala Asp Thr Pro Glu Lys Leu Arg Ala Leu 
                805                 810                 815     


Leu Ala Glu Lys Leu Ser Ser Arg Pro Glu Ala Val His Glu Tyr Val 
            820                 825                 830         


Ala Pro Leu Phe Val Ser Arg Ala Pro Asn Arg Lys Met Ser Gly Gln 
        835                 840                 845             


Gly His Met Glu Thr Ile Lys Ser Pro Lys Arg Leu Asp Glu Gly Ile 
    850                 855                 860                 


Ser Val Val Arg Val Pro Leu Thr Gln Leu Lys Leu Lys Asp Leu Glu 
865                 870                 875                 880 


Lys Met Val Asn Arg Glu Arg Glu Pro Lys Leu Tyr Glu Ala Leu Lys 
                885                 890                 895     


Ala Arg Leu Glu Ala His Lys Asp Asp Pro Ala Lys Ala Phe Ala Glu 
            900                 905                 910         


Pro Phe Tyr Lys Gln Asp Lys Ala Gly Asn Arg Thr Gln Gln Val Lys 
        915                 920                 925             


Ala Val Arg Ile Glu Gln Val Gln Lys Thr Gly Val Trp Val Arg Asn 
    930                 935                 940                 


Gln Asn Gly Ile Ala Asp Asn Ala Thr Met Val Arg Val Asp Val Phe 
945                 950                 955                 960 


Glu Lys Gly Gly Lys Tyr Tyr Leu Val Pro Ile Tyr Ser Trp Gln Val 
                965                 970                 975     


Ala Lys Gly Ile Leu Pro Asp Lys Ala Ile Ile Ala Phe Lys Asp Glu 
            980                 985                 990         


Glu Glu Trp Gln Leu Ile Asp Asp  Ser Phe Asn Phe Lys  Phe Pro Leu 
        995                 1000                 1005             


His Pro  Asn Asp Leu Val Glu  Val Ile Thr Lys Lys  Ala Arg Ile 
    1010                 1015                 1020             


Phe Gly  Tyr Phe Ala Ser Cys  His Arg Gly Thr Gly  Asn Ile Asn 
    1025                 1030                 1035             


Ile Arg  Ile His Asp Leu Asp  Asn Lys Val Gly Lys  Asn Gly Ile 
    1040                 1045                 1050             


Leu Glu  Gly Ile Gly Val Lys  Thr Ala Leu Ser Phe  Gln Lys Tyr 
    1055                 1060                 1065             


Gln Ile  Asp Glu Leu Gly Lys  Glu Ile Arg Pro Cys  Arg Leu Lys 
    1070                 1075                 1080             


Lys Arg  Pro Pro Val Arg 
    1085                 


<210> 364
<211> 1097
<212> PRT
<213> Neisseria wadsworthii


<220>
<223> Neisseria wadsworthii 9715

<400> 364
Met Lys Lys Gln Pro Gln Arg Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Leu Ile Leu Val Asp Gly Ala Glu Asn Pro 
            20                  25                  30          


Val Gly Leu Leu Asp Cys Gly Val Arg Thr Phe Glu Arg Ala Glu Val 
        35                  40                  45              


Pro Lys Thr Gly Asp Ser Leu Ala Leu Ala Arg Arg Gln Ala Arg Ser 
    50                  55                  60                  


Val Arg Arg Leu Ile Arg Arg Arg Ala His Arg Leu Leu Arg Leu Arg 
65                  70                  75                  80  


Arg Leu Leu Lys Arg Glu Gly Ile Leu Ser Ala Ala Asp Phe Asn Ser 
                85                  90                  95      


Asp Gly Leu Pro Asn Leu Pro Ile Asp Ala Trp Gln Leu Arg Val Ala 
            100                 105                 110         


Gly Leu Glu Arg Lys Leu Thr Asn Gln Glu Trp Ala Ala Val Leu Leu 
        115                 120                 125             


His Leu Val Lys His Arg Gly Tyr Leu Ser Gln Arg Lys Ser Glu Thr 
    130                 135                 140                 


Gln Thr Glu Asn Lys Glu Leu Gly Arg Leu Leu Ala Gly Val Ala Glu 
145                 150                 155                 160 


Asn Ser Lys Leu Leu Ser Glu Ser Ser Glu Gln Tyr Arg Thr Pro Ala 
                165                 170                 175     


Glu Leu Ala Val Lys Leu Phe Ala Glu Gln Ser Gly His Leu Arg Asn 
            180                 185                 190         


Lys Gly Gly Glu Tyr Thr His Thr Phe Asn Arg Leu Asp Leu Gln Lys 
        195                 200                 205             


Glu Leu His Leu Leu Phe Glu Arg Gln Tyr Ala Leu Gly Asn Pro Phe 
    210                 215                 220                 


Ala Ser Ala Glu Leu Gln Ser Lys Val Asp Glu Leu Leu Met Thr Gln 
225                 230                 235                 240 


Arg Ser Ala Leu Gln Gly Glu Ala Val Leu Lys Met Leu Gly Lys Cys 
                245                 250                 255     


Thr Phe Glu Pro Ser Glu Tyr Lys Ala Ala Lys Asn Thr Tyr Ser Ala 
            260                 265                 270         


Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile Leu Tyr 
        275                 280                 285             


Asn Gly Glu Glu Arg Ala Leu Asp Glu Gly Asp Arg Lys Lys Leu Leu 
    290                 295                 300                 


Asp Glu Pro Tyr Lys Lys Ala Lys Leu Thr Tyr Lys Gln Val Arg Ser 
305                 310                 315                 320 


Ile Leu Asn Leu Pro Glu Ser Ala Val Phe Lys Gly Leu Arg Tyr Gly 
                325                 330                 335     


Lys Asp Ser Asp Gly Leu Lys Ala Glu Asn Gly Thr Leu Met Glu Met 
            340                 345                 350         


Lys Ala Tyr His Lys Ile Arg Thr Ile Leu Asp Lys Ala Gly Leu Lys 
        355                 360                 365             


Gly Glu Trp Glu Asn Arg Ile Arg Asn Pro Glu Ile Leu Asp Lys Ile 
    370                 375                 380                 


Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp Glu Asp Ile Gln Ala Ala 
385                 390                 395                 400 


Leu Ala Asp Leu Arg Leu Pro Glu Asn Val Leu Asp Ala Leu Leu Ala 
                405                 410                 415     


Gly Leu Asn Phe Asp Lys Phe Ile Gln Leu Ser Leu Lys Ala Leu Arg 
            420                 425                 430         


Asn Ile Leu Pro Leu Met Glu Arg Gly Ile Arg Tyr Asp Glu Ala Cys 
        435                 440                 445             


Lys Glu Val Tyr Gly Asp His Arg Ala Leu Ala Glu Ser Lys Asn Gln 
    450                 455                 460                 


Val Leu Leu Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val 
465                 470                 475                 480 


Leu Arg Thr Leu Thr Gln Ala Arg Lys Val Ile Asn Ala Ile Ile Arg 
                485                 490                 495     


Arg Tyr Gly Ser Pro Gln Arg Val His Ile Glu Thr Ala Arg Glu Leu 
            500                 505                 510         


Gly Lys Ser Lys Gln Glu Arg Asp Lys Ile Asp Arg Lys Asn Lys Glu 
        515                 520                 525             


Asn Gln Asn Asp Arg Asn Arg Leu Ala Ser Asp Ile Arg Lys His Phe 
    530                 535                 540                 


Asn Phe Glu Pro Thr Pro Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Asp Leu Arg Glu Glu Lys Gly 
                565                 570                 575     


Glu Cys Leu Tyr Thr Gly Asn Val Ile Glu Leu His Arg Leu Phe Glu 
            580                 585                 590         


Asp Gly Tyr Val Glu Ile Asp His Ala Leu Pro Leu Ser Arg Thr Trp 
        595                 600                 605             


Asp Asn Ser Leu Asn Asn Lys Val Leu Val Leu Lys Ser Ser Asn Gln 
    610                 615                 620                 


Asn Lys Gly Asn Lys Thr Pro Tyr Glu Trp Leu Asp Gly Ala Asn Asn 
625                 630                 635                 640 


Ser Arg Arg Trp Arg Glu Phe Gln Ala Arg Val Gln Gly Cys His Phe 
                645                 650                 655     


Pro Tyr Val Lys Lys Gln Arg Ile Gln Thr Ala Lys Leu Asp Ser Lys 
            660                 665                 670         


Ala Glu Gln Gly Phe Leu Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ile 
        675                 680                 685             


Ser Lys Phe Met Cys Gln Phe Ile Thr Ala Asn Leu Arg Leu Ala Glu 
    690                 695                 700                 


Thr Ser Asn Ala Leu Met Glu Glu Val Ala Gly Glu Asn Pro Tyr Trp 
705                 710                 715                 720 


Lys Glu Arg Lys Arg Gln Arg Val Phe Ala Pro Ser Gly Ser Ile Ile 
                725                 730                 735     


Ala Leu Leu Arg Gly Leu Trp Gly Leu Lys Lys Val Arg Glu Asp Asn 
            740                 745                 750         


Asp Arg His His Ala Leu Asp Ala Ile Val Val Ala Cys Ser Thr Val 
        755                 760                 765             


Ser Met Gln Gln Lys Ile Thr Lys Ala Met Gln Arg Arg Glu Thr Leu 
    770                 775                 780                 


Glu Thr Val Asp Ser Glu Thr Gly Glu Val Lys Thr Arg Ile Pro Gln 
785                 790                 795                 800 


Pro Trp Asp Phe Phe Arg Gln Glu Val Met Ile Arg Val Phe Ser Asp 
                805                 810                 815     


Ser Pro Arg Glu Glu Leu Ala Glu Lys Leu Asn Ser Arg Pro Glu Ala 
            820                 825                 830         


Leu His Asp Phe Val Ser Pro Leu Phe Val Ser Arg Ala Pro Asn Arg 
        835                 840                 845             


Lys Met Thr Gly Gln Gly His Leu Glu Thr Val Lys Ser Ala Lys Arg 
    850                 855                 860                 


Leu Ser Glu Asn Ile Ser Val Val Arg Lys Pro Leu Thr Ala Leu Lys 
865                 870                 875                 880 


Leu Lys Asp Ile Glu Asn Ile Val Gly Tyr Pro Asp Arg Glu Pro Ala 
                885                 890                 895     


Leu Tyr Gln Ala Leu Arg Glu Arg Leu Leu Ala His Lys Asp Asp Pro 
            900                 905                 910         


Val Lys Ala Phe Ala Asp Lys Pro Phe Tyr Lys Pro Ala Lys Asp Gly 
        915                 920                 925             


Gly Gln Gly Ser Leu Val Lys Ala Val Arg Ile Ile Glu Asn Thr Lys 
    930                 935                 940                 


His Gly Leu Lys Ile Arg Asn Gly Ile Thr Asp Thr Asn Gly Asp Met 
945                 950                 955                 960 


Val Arg Thr Asp Val Tyr Gln Lys Thr Asp Lys Lys Gly Lys Arg Gln 
                965                 970                 975     


Tyr Phe Ile Val Pro Val Tyr Ala Trp Gln Val Glu Lys Asn Glu Leu 
            980                 985                 990         


Pro Thr Val Asp Cys Lys Gly Tyr  Glu Ile Asp Asp Asn  Tyr Glu Phe 
        995                 1000                 1005             


Cys Phe  Ser Leu Tyr Lys Tyr  Asp Leu Ile Glu Ile  Gln Asn Pro 
    1010                 1015                 1020             


Asn Asp  Ile Asn Gln Glu Leu  Arg Ala Tyr Tyr Ile  Asn Cys Asp 
    1025                 1030                 1035             


Ser Ser  Asp Gly Arg Phe Trp  Leu Ala Tyr His Asp  Lys Ser Ala 
    1040                 1045                 1050             


Lys Glu  Gln Gln Phe Arg Ile  Ser Thr Gln Asn Gln  Pro Ile Ile 
    1055                 1060                 1065             


Lys Lys  Tyr Gln Val Asp Thr  Leu Gly Lys Glu Ile  Arg Leu Cys 
    1070                 1075                 1080             


Lys Ala  Glu Lys Arg Thr Ala  Leu Asn Gly Lys Lys  Lys Lys 
    1085                 1090                 1095         


<210> 365
<211> 1426
<212> PRT
<213> Niabella soli


<220>
<223> Niabella soli DSM 19437

<400> 365
Met Pro Arg Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile 
1               5                   10                  15      


Gly Phe Ala Lys Ile Ile Glu Asp Asp Asp Tyr Gln Cys Ser Ser Val 
            20                  25                  30          


Glu Leu Ile Gly Val Arg Val Asn Pro Leu Thr Thr Asp Glu Gln Thr 
        35                  40                  45              


Asn Phe Glu Lys Gly Lys Pro Val Ser Val Asn Ala Asp Arg Thr Leu 
    50                  55                  60                  


Lys Arg Gly Met Arg Arg Asn Leu Asp Arg Tyr Gln Leu Arg Arg Asp 
65                  70                  75                  80  


Tyr Leu Ile Glu Ile Leu Arg Thr His His Ile Ile Thr Ala Asp Thr 
                85                  90                  95      


Lys Leu Ala Glu Asp Gly Lys Asn Thr Thr His Thr Thr Tyr Ala Leu 
            100                 105                 110         


Arg Ala Leu Ala Ala Thr Ala Glu Ile Pro Leu Glu Ala Phe Val Arg 
        115                 120                 125             


Val Leu Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys 
    130                 135                 140                 


Ala Lys Asn Glu Asp Glu Gly Gln Leu Ile Asp Gly Met Ala Ile Ala 
145                 150                 155                 160 


Arg Arg Leu Tyr Glu Glu Ser Leu Thr Pro Gly Gln Phe Ser Tyr Gln 
                165                 170                 175     


Leu Leu Lys Glu Gly Lys Lys Tyr Leu Pro Asp Phe Tyr Arg Ser Asp 
            180                 185                 190         


Leu Asn Thr Glu Leu Asn Lys Val Trp Asn Phe Gln Lys Gln Phe Tyr 
        195                 200                 205             


Pro Glu Ile Leu Thr Asp Glu Phe Lys Arg His Leu Glu Gly Lys Gly 
    210                 215                 220                 


Gln Arg Ala Thr Ala Val Ala Phe Trp Gly Gln His Gly Phe Ser Met 
225                 230                 235                 240 


Ala Glu Asn Lys Gly Ser Arg Glu Glu Lys Lys Leu His Ala Tyr Lys 
                245                 250                 255     


Trp Arg Ser Glu Ala Ala His Lys Gln Leu Thr Lys Glu Glu Val Ala 
            260                 265                 270         


Phe Val Ile Thr Glu Ile Asn Asn Asp Leu Asn Lys Ser Ser Gly Tyr 
        275                 280                 285             


Leu Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Phe Phe Asn Lys Gln 
    290                 295                 300                 


Thr Val Gly Gln Tyr Leu His Gln Gln Leu Lys Glu Asn Pro His Thr 
305                 310                 315                 320 


Arg Leu Lys Gly Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe 
                325                 330                 335     


Glu Thr Ile Trp Glu Met Gln Ala Lys Phe Tyr Ser Ala Leu Thr Leu 
            340                 345                 350         


Glu Leu Lys Glu Glu Val Arg Asp Val Val Ile Phe Tyr Gln Arg Lys 
        355                 360                 365             


Leu Lys Ser Gln Met Gly Leu Ile Ser Leu Cys Glu Phe Glu Ser Lys 
    370                 375                 380                 


Glu Ile Glu Ile Glu Lys Asn Gly Glu Lys Ala Lys Lys Arg Ile Gly 
385                 390                 395                 400 


Leu Arg Val Ala Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys Ile 
                405                 410                 415     


Trp Gln Val Leu Asn Asn Leu Glu Phe Arg Asn Lys Lys Thr Lys Glu 
            420                 425                 430         


Val Phe Val Pro Glu Met Ala Ala Lys Gln Gln Leu Phe Asp Glu Leu 
        435                 440                 445             


Asn Ile Lys Gly Asn Leu Leu Ala Ser Glu Ala Ile Lys Ile Leu Gly 
    450                 455                 460                 


Tyr Lys Thr Lys Asp Trp Glu Ala Asn Tyr His Thr Leu Glu Gly Asn 
465                 470                 475                 480 


Arg Thr Asn Lys Ser Leu Tyr Asp Ala Trp Leu Lys Ile Leu Glu Leu 
                485                 490                 495     


Glu Gly Tyr Asp Glu Asn Leu Leu Lys Leu Ser Gly Ser Asp Asp Ile 
            500                 505                 510         


Asp Val Ser Lys Ile Glu Lys Pro Ala Leu Glu Ile Arg Gln Met Val 
        515                 520                 525             


Leu Ala Val Phe Glu Val Leu Gly Ile Ser Gly Ala Ile Leu Asp Phe 
    530                 535                 540                 


Asp Ala Glu Ala Asp Gly Lys Ala Phe Glu Gln Gln Pro Ala Tyr Gln 
545                 550                 555                 560 


Leu Trp His Leu Leu Tyr Ser Ala Glu Asp Asp Gly Lys Lys Tyr Ser 
                565                 570                 575     


Gln Glu Asp Ile Phe Thr Tyr Gly His Asp Asn Ile Gly Leu Lys Lys 
            580                 585                 590         


Lys Leu Cys Glu Lys Phe Gly Phe Arg Pro Glu His Thr Lys Ile Leu 
        595                 600                 605             


Val Asn Val Val Phe Ser Asp Asp Tyr Gly Asn Leu Ser Ser Lys Ala 
    610                 615                 620                 


Met Arg Arg Ile Tyr Pro Phe Ile Lys Glu Leu Thr Tyr Asp Lys Ala 
625                 630                 635                 640 


Cys Ala Glu Ala Gly Tyr Arg His Ser Ala Ala Ser Leu Thr Lys Glu 
                645                 650                 655     


Glu Ile Ala Ala Arg Pro Leu Gln Asn Arg Leu Asp Leu Leu Lys Lys 
            660                 665                 670         


Asn Glu Leu Arg Ser Pro Val Val Glu Lys Ile Leu Asn Gln Met Val 
        675                 680                 685             


Asn Val Val Asn Thr Leu Val Asp Asp Glu Asn Gln Asn Arg Lys Ala 
    690                 695                 700                 


Arg Gly Leu Ser Glu Asp Phe His Phe Asp Glu Ile Arg Ile Glu Leu 
705                 710                 715                 720 


Ala Arg Glu Leu Lys Lys Asn Ala Lys Glu Arg Ala Glu Met Thr Thr 
                725                 730                 735     


Asn Ile Asn Thr Ala Lys Gln Ser His Glu Lys Ile Ile Arg Ile Leu 
            740                 745                 750         


Gln Thr Glu Phe Gly Val Pro Asn Pro Ser Arg Asn Asp Ile Val Arg 
        755                 760                 765             


Tyr Lys Leu Tyr Glu Glu Leu Lys Asn Asn Gly Tyr Lys Asp Leu Tyr 
    770                 775                 780                 


Thr Asn Thr Tyr Ile Ser Arg Asp Ile Leu Phe Ser Lys Gln Ile Asp 
785                 790                 795                 800 


Val Asp His Ile Ile Pro Gln Met Ser Leu Phe Asp Asp Ser Phe Ser 
                805                 810                 815     


Asn Lys Thr Val Val Phe Arg Lys Asp Asn Gln Asp Lys Gly Asn Lys 
            820                 825                 830         


Thr Ala Tyr Asp Tyr Ile Leu Gly Lys Tyr Gly Glu Gln Ala Leu Glu 
        835                 840                 845             


Glu Tyr Ile Ser Arg Ile Thr Ser Leu Phe Glu Leu Gly Lys Lys Asn 
    850                 855                 860                 


Lys Glu Glu Gly Ile Gly Lys Ala Lys Phe Gln Lys Leu Gln Lys Arg 
865                 870                 875                 880 


Leu Val Asp Ile Gly Asp Gly Phe Ile Glu Arg Asp Leu Arg Glu Ser 
                885                 890                 895     


Gln Tyr Ile Ala Lys Lys Ala Asn Asn Met Leu Tyr Ala Ile Cys Arg 
            900                 905                 910         


Ser Val Val Ser Thr Ser Gly Glu Ile Thr Ala Arg Leu Arg Glu Asp 
        915                 920                 925             


Trp Asp Leu Val Asn Val Met Gln Glu Ile Asn Leu Pro Lys Phe Arg 
    930                 935                 940                 


Ala Leu Gly Leu Thr Glu Met Val Glu Lys Lys Asp Gly Ala Gln Lys 
945                 950                 955                 960 


Glu Arg Ile Thr Asp Trp Thr Lys Arg Asn Asp His Arg His His Ala 
                965                 970                 975     


Met Asp Ala Leu Ala Ile Ala Phe Thr Arg His Ser His Ile Gln Tyr 
            980                 985                 990         


Leu Asn His Leu Asn Ala Arg Lys  Asp Glu Ala Asn Lys  Trp His Pro 
        995                 1000                 1005             


Val Val  Ser Lys Ile Glu Glu  Lys Glu Thr Val Leu  Ile Tyr Asp 
    1010                 1015                 1020             


Asp Leu  Gly Asn Arg Lys Arg  Lys Phe Lys Ala Pro  Met Pro Asn 
    1025                 1030                 1035             


Phe Arg  Glu Val Val Lys Glu  His Leu Glu Asn Val  Leu Ile Ser 
    1040                 1045                 1050             


His Lys  Ala Lys Asn Lys Val  Val Thr Lys Asn Lys  Asn Lys Ile 
    1055                 1060                 1065             


Lys Thr  Val Arg Gly Glu Lys  Val Lys Thr Glu Leu  Thr Pro Arg 
    1070                 1075                 1080             


Gly Gln  Leu His Lys Glu Thr  Ile Tyr Gly Arg Tyr  Arg Tyr Tyr 
    1085                 1090                 1095             


Glu Ser  Lys Glu Glu Lys Ile  Gly Pro Lys Phe Asp  Ala Glu Met 
    1100                 1105                 1110             


Ile Gly  Met Val Thr Asn Pro  Gln Tyr Lys Lys Leu  Leu Leu Glu 
    1115                 1120                 1125             


Arg Leu  Ala Ala Asn Gly Asn  Asp Pro Lys Lys Ala  Phe Trp Gly 
    1130                 1135                 1140             


Lys Asn  Ala Leu Asn Lys Asn  Pro Leu Tyr Val Asp  Glu Ala Arg 
    1145                 1150                 1155             


Gln Glu  Leu Leu Pro Glu Lys  Ile Leu Leu Arg Trp  Leu Asn Asp 
    1160                 1165                 1170             


Asp Tyr  Ser Ile Arg Lys Asp  Val Thr Pro Glu Asn  Leu Lys Asp 
    1175                 1180                 1185             


Ile Lys  Thr Ile Glu Lys Ile  Leu Asp Lys Gly Val  Lys Lys Ile 
    1190                 1195                 1200             


Leu Leu  Lys Arg Leu Ala Asp  Phe Gly Asn Asp Pro  Lys Lys Ala 
    1205                 1210                 1215             


Phe Ser  Asp Leu Asp Lys Asn  Pro Ile Trp Gln Asn  Glu Ala Lys 
    1220                 1225                 1230             


Arg Ile  Ala Ile Lys Arg Val  Thr Ile Ser Gly Ile  Lys Asn Ala 
    1235                 1240                 1245             


Ala Pro  Leu His His Lys Lys  Asp His Leu Gly Asn  Asp Ile Leu 
    1250                 1255                 1260             


Asp Glu  Lys Gly Lys Gln Ile  Pro Ser Ser Phe Val  Ser Thr Gly 
    1265                 1270                 1275             


Asn Asn  His His Val Ala Ile  Tyr Arg Asp Ala Glu  Gly Asn Leu 
    1280                 1285                 1290             


Gln Glu  Arg Val Val Ser Leu  Phe Asp Ala Val Gln  Leu Val Asn 
    1295                 1300                 1305             


Gly Gly  Glu Pro Val Ile Asp  Lys Glu Tyr Asn Lys  Gly Ile Gly 
    1310                 1315                 1320             


Trp Gln  Phe Leu Phe Thr Met  Lys Gln Asn Glu Met  Phe Val Phe 
    1325                 1330                 1335             


Pro Asp  Glu Lys Thr Gly Phe  Asn Pro Arg Glu Val  Asp Leu Leu 
    1340                 1345                 1350             


Ser Ser  Gly Asn Arg Lys Leu  Ile Ser Pro Asn Leu  Phe Arg Val 
    1355                 1360                 1365             


Gln Lys  Leu Ala Ser Lys Asn  Tyr Phe Phe Arg His  His Leu Glu 
    1370                 1375                 1380             


Thr Ser  Val Glu Glu Lys Lys  Glu Leu Lys Asn Ile  Ala Tyr Lys 
    1385                 1390                 1395             


Pro Gln  Leu Gly Leu Asn Ala  Leu Ser Asn Ile Val  Lys Val Arg 
    1400                 1405                 1410             


Ile Asn  His Ile Gly Glu Ile  Val Ser Val Gly Glu  Tyr 
    1415                 1420                 1425     


<210> 366
<211> 1132
<212> PRT
<213> Nitratifractor salsuginis

<400> 366
Met Lys Lys Ile Leu Gly Val Asp Leu Gly Ile Thr Ser Phe Gly Tyr 
1               5                   10                  15      


Ala Ile Leu Gln Glu Thr Gly Lys Asp Leu Tyr Arg Cys Leu Asp Asn 
            20                  25                  30          


Ser Val Val Met Arg Asn Asn Pro Tyr Asp Glu Lys Ser Gly Glu Ser 
        35                  40                  45              


Ser Gln Ser Ile Arg Ser Thr Gln Lys Ser Met Arg Arg Leu Ile Glu 
    50                  55                  60                  


Lys Arg Lys Lys Arg Ile Arg Cys Val Ala Gln Thr Met Glu Arg Tyr 
65                  70                  75                  80  


Gly Ile Leu Asp Tyr Ser Glu Thr Met Lys Ile Asn Asp Pro Lys Asn 
                85                  90                  95      


Asn Pro Ile Lys Asn Arg Trp Gln Leu Arg Ala Val Asp Ala Trp Lys 
            100                 105                 110         


Arg Pro Leu Ser Pro Gln Glu Leu Phe Ala Ile Phe Ala His Met Ala 
        115                 120                 125             


Lys His Arg Gly Tyr Lys Ser Ile Ala Thr Glu Asp Leu Ile Tyr Glu 
    130                 135                 140                 


Leu Glu Leu Glu Leu Gly Leu Asn Asp Pro Glu Lys Glu Ser Glu Lys 
145                 150                 155                 160 


Lys Ala Asp Glu Arg Arg Gln Val Tyr Asn Ala Leu Arg His Leu Glu 
                165                 170                 175     


Glu Leu Arg Lys Lys Tyr Gly Gly Glu Thr Ile Ala Gln Thr Ile His 
            180                 185                 190         


Arg Ala Val Glu Ala Gly Asp Leu Arg Ser Tyr Arg Asn His Asp Asp 
        195                 200                 205             


Tyr Glu Lys Met Ile Arg Arg Glu Asp Ile Glu Glu Glu Ile Glu Lys 
    210                 215                 220                 


Val Leu Leu Arg Gln Ala Glu Leu Gly Ala Leu Gly Leu Pro Glu Glu 
225                 230                 235                 240 


Gln Val Ser Glu Leu Ile Asp Glu Leu Lys Ala Cys Ile Thr Asp Gln 
                245                 250                 255     


Glu Met Pro Thr Ile Asp Glu Ser Leu Phe Gly Lys Cys Thr Phe Tyr 
            260                 265                 270         


Lys Asp Glu Leu Ala Ala Pro Ala Tyr Ser Tyr Leu Tyr Asp Leu Tyr 
        275                 280                 285             


Arg Leu Tyr Lys Lys Leu Ala Asp Leu Asn Ile Asp Gly Tyr Glu Val 
    290                 295                 300                 


Thr Gln Glu Asp Arg Glu Lys Val Ile Glu Trp Val Glu Lys Lys Ile 
305                 310                 315                 320 


Ala Gln Gly Lys Asn Leu Lys Lys Ile Thr His Lys Asp Leu Arg Lys 
                325                 330                 335     


Ile Leu Gly Leu Ala Pro Glu Gln Lys Ile Phe Gly Val Glu Asp Glu 
            340                 345                 350         


Arg Ile Val Lys Gly Lys Lys Glu Pro Arg Thr Phe Val Pro Phe Phe 
        355                 360                 365             


Phe Leu Ala Asp Ile Ala Lys Phe Lys Glu Leu Phe Ala Ser Ile Gln 
    370                 375                 380                 


Lys His Pro Asp Ala Leu Gln Ile Phe Arg Glu Leu Ala Glu Ile Leu 
385                 390                 395                 400 


Gln Arg Ser Lys Thr Pro Gln Glu Ala Leu Asp Arg Leu Arg Ala Leu 
                405                 410                 415     


Met Ala Gly Lys Gly Ile Asp Thr Asp Asp Arg Glu Leu Leu Glu Leu 
            420                 425                 430         


Phe Lys Asn Lys Arg Ser Gly Thr Arg Glu Leu Ser His Arg Tyr Ile 
        435                 440                 445             


Leu Glu Ala Leu Pro Leu Phe Leu Glu Gly Tyr Asp Glu Lys Glu Val 
    450                 455                 460                 


Gln Arg Ile Leu Gly Phe Asp Asp Arg Glu Asp Tyr Ser Arg Tyr Pro 
465                 470                 475                 480 


Lys Ser Leu Arg His Leu His Leu Arg Glu Gly Asn Leu Phe Glu Lys 
                485                 490                 495     


Glu Glu Asn Pro Ile Asn Asn His Ala Val Lys Ser Leu Ala Ser Trp 
            500                 505                 510         


Ala Leu Gly Leu Ile Ala Asp Leu Ser Trp Arg Tyr Gly Pro Phe Asp 
        515                 520                 525             


Glu Ile Ile Leu Glu Thr Thr Arg Asp Ala Leu Pro Glu Lys Ile Arg 
    530                 535                 540                 


Lys Glu Ile Asp Lys Ala Met Arg Glu Arg Glu Lys Ala Leu Asp Lys 
545                 550                 555                 560 


Ile Ile Gly Lys Tyr Lys Lys Glu Phe Pro Ser Ile Asp Lys Arg Leu 
                565                 570                 575     


Ala Arg Lys Ile Gln Leu Trp Glu Arg Gln Lys Gly Leu Asp Leu Tyr 
            580                 585                 590         


Ser Gly Lys Val Ile Asn Leu Ser Gln Leu Leu Asp Gly Ser Ala Asp 
        595                 600                 605             


Ile Glu His Ile Val Pro Gln Ser Leu Gly Gly Leu Ser Thr Asp Tyr 
    610                 615                 620                 


Asn Thr Ile Val Thr Leu Lys Ser Val Asn Ala Ala Lys Gly Asn Arg 
625                 630                 635                 640 


Leu Pro Gly Asp Trp Leu Ala Gly Asn Pro Asp Tyr Arg Glu Arg Ile 
                645                 650                 655     


Gly Met Leu Ser Glu Lys Gly Leu Ile Asp Trp Lys Lys Arg Lys Asn 
            660                 665                 670         


Leu Leu Ala Gln Ser Leu Asp Glu Ile Tyr Thr Glu Asn Thr His Ser 
        675                 680                 685             


Lys Gly Ile Arg Ala Thr Ser Tyr Leu Glu Ala Leu Val Ala Gln Val 
    690                 695                 700                 


Leu Lys Arg Tyr Tyr Pro Phe Pro Asp Pro Glu Leu Arg Lys Asn Gly 
705                 710                 715                 720 


Ile Gly Val Arg Met Ile Pro Gly Lys Val Thr Ser Lys Thr Arg Ser 
                725                 730                 735     


Leu Leu Gly Ile Lys Ser Lys Ser Arg Glu Thr Asn Phe His His Ala 
            740                 745                 750         


Glu Asp Ala Leu Ile Leu Ser Thr Leu Thr Arg Gly Trp Gln Asn Arg 
        755                 760                 765             


Leu His Arg Met Leu Arg Asp Asn Tyr Gly Lys Ser Glu Ala Glu Leu 
    770                 775                 780                 


Lys Glu Leu Trp Lys Lys Tyr Met Pro His Ile Glu Gly Leu Thr Leu 
785                 790                 795                 800 


Ala Asp Tyr Ile Asp Glu Ala Phe Arg Arg Phe Met Ser Lys Gly Glu 
                805                 810                 815     


Glu Ser Leu Phe Tyr Arg Asp Met Phe Asp Thr Ile Arg Ser Ile Ser 
            820                 825                 830         


Tyr Trp Val Asp Lys Lys Pro Leu Ser Ala Ser Ser His Lys Glu Thr 
        835                 840                 845             


Val Tyr Ser Ser Arg His Glu Val Pro Thr Leu Arg Lys Asn Ile Leu 
    850                 855                 860                 


Glu Ala Phe Asp Ser Leu Asn Val Ile Lys Asp Arg His Lys Leu Thr 
865                 870                 875                 880 


Thr Glu Glu Phe Met Lys Arg Tyr Asp Lys Glu Ile Arg Gln Lys Leu 
                885                 890                 895     


Trp Leu His Arg Ile Gly Asn Thr Asn Asp Glu Ser Tyr Arg Ala Val 
            900                 905                 910         


Glu Glu Arg Ala Thr Gln Ile Ala Gln Ile Leu Thr Arg Tyr Gln Leu 
        915                 920                 925             


Met Asp Ala Gln Asn Asp Lys Glu Ile Asp Glu Lys Phe Gln Gln Ala 
    930                 935                 940                 


Leu Lys Glu Leu Ile Thr Ser Pro Ile Glu Val Thr Gly Lys Leu Leu 
945                 950                 955                 960 


Arg Lys Met Arg Phe Val Tyr Asp Lys Leu Asn Ala Met Gln Ile Asp 
                965                 970                 975     


Arg Gly Leu Val Glu Thr Asp Lys Asn Met Leu Gly Ile His Ile Ser 
            980                 985                 990         


Lys Gly Pro Asn Glu Lys Leu Ile  Phe Arg Arg Met Asp  Val Asn Asn 
        995                 1000                 1005             


Ala His  Glu Leu Gln Lys Glu  Arg Ser Gly Ile Leu  Cys Tyr Leu 
    1010                 1015                 1020             


Asn Glu  Met Leu Phe Ile Phe  Asn Lys Lys Gly Leu  Ile His Tyr 
    1025                 1030                 1035             


Gly Cys  Leu Arg Ser Tyr Leu  Glu Lys Gly Gln Gly  Ser Lys Tyr 
    1040                 1045                 1050             


Ile Ala  Leu Phe Asn Pro Arg  Phe Pro Ala Asn Pro  Lys Ala Gln 
    1055                 1060                 1065             


Pro Ser  Lys Phe Thr Ser Asp  Ser Lys Ile Lys Gln  Val Gly Ile 
    1070                 1075                 1080             


Gly Ser  Ala Thr Gly Ile Ile  Lys Ala His Leu Asp  Leu Asp Gly 
    1085                 1090                 1095             


His Val  Arg Ser Tyr Glu Val  Phe Gly Thr Leu Pro  Glu Gly Ser 
    1100                 1105                 1110             


Ile Glu  Trp Phe Lys Glu Glu  Ser Gly Tyr Gly Arg  Val Glu Asp 
    1115                 1120                 1125             


Asp Pro  His His 
    1130         


<210> 367
<211> 1166
<212> PRT
<213> Nitrobacter hamburgensis

<400> 367
Met His Val Glu Ile Asp Phe Pro His Phe Ser Arg Gly Asp Ser His 
1               5                   10                  15      


Leu Ala Met Asn Lys Asn Glu Ile Leu Arg Gly Ser Ser Val Leu Tyr 
            20                  25                  30          


Arg Leu Gly Leu Asp Leu Gly Ser Asn Ser Leu Gly Trp Phe Val Thr 
        35                  40                  45              


His Leu Glu Lys Arg Gly Asp Arg His Glu Pro Val Ala Leu Gly Pro 
    50                  55                  60                  


Gly Gly Val Arg Ile Phe Pro Asp Gly Arg Asp Pro Gln Ser Gly Thr 
65                  70                  75                  80  


Ser Asn Ala Val Asp Arg Arg Met Ala Arg Gly Ala Arg Lys Arg Arg 
                85                  90                  95      


Asp Arg Phe Val Glu Arg Arg Lys Glu Leu Ile Ala Ala Leu Ile Lys 
            100                 105                 110         


Tyr Asn Leu Leu Pro Asp Asp Ala Arg Glu Arg Arg Ala Leu Glu Val 
        115                 120                 125             


Leu Asp Pro Tyr Ala Leu Arg Lys Thr Ala Leu Thr Asp Thr Leu Pro 
    130                 135                 140                 


Ala His His Val Gly Arg Ala Leu Phe His Leu Asn Gln Arg Arg Gly 
145                 150                 155                 160 


Phe Gln Ser Asn Arg Lys Thr Asp Ser Lys Gln Ser Glu Asp Gly Ala 
                165                 170                 175     


Ile Lys Gln Ala Ala Ser Arg Leu Ala Thr Asp Lys Gly Asn Glu Thr 
            180                 185                 190         


Leu Gly Val Phe Phe Ala Asp Met His Leu Arg Lys Ser Tyr Glu Asp 
        195                 200                 205             


Arg Gln Thr Ala Ile Arg Ala Glu Leu Val Arg Leu Gly Lys Asp His 
    210                 215                 220                 


Leu Thr Gly Asn Ala Arg Lys Lys Ile Trp Ala Lys Val Arg Lys Arg 
225                 230                 235                 240 


Leu Phe Gly Asp Glu Val Leu Pro Arg Ala Asp Ala Pro His Gly Val 
                245                 250                 255     


Arg Ala Arg Ala Thr Ile Thr Gly Thr Lys Ala Ser Tyr Asp Tyr Tyr 
            260                 265                 270         


Pro Thr Arg Asp Met Leu Arg Asp Glu Phe Asn Ala Ile Trp Ala Gly 
        275                 280                 285             


Gln Ser Ala His His Ala Thr Ile Thr Asp Glu Ala Arg Thr Glu Ile 
    290                 295                 300                 


Glu His Ile Ile Phe Tyr Gln Arg Pro Leu Lys Pro Ala Ile Val Gly 
305                 310                 315                 320 


Lys Cys Thr Leu Asp Pro Ala Thr Arg Pro Phe Lys Glu Asp Pro Glu 
                325                 330                 335     


Gly Tyr Arg Ala Pro Trp Ser His Pro Leu Ala Gln Arg Phe Arg Ile 
            340                 345                 350         


Leu Ser Glu Ala Arg Asn Leu Glu Ile Arg Asp Thr Gly Lys Gly Ser 
        355                 360                 365             


Arg Arg Leu Thr Lys Glu Gln Ser Asp Leu Val Val Ala Ala Leu Leu 
    370                 375                 380                 


Ala Asn Arg Glu Val Lys Phe Asp Lys Leu Arg Thr Leu Leu Lys Leu 
385                 390                 395                 400 


Pro Ala Glu Ala Arg Phe Asn Leu Glu Ser Asp Arg Arg Ala Ala Leu 
                405                 410                 415     


Asp Gly Asp Gln Thr Ala Ala Arg Leu Ser Asp Lys Lys Gly Phe Asn 
            420                 425                 430         


Lys Ala Trp Arg Gly Phe Pro Pro Glu Arg Gln Ile Ala Ile Val Ala 
        435                 440                 445             


Arg Leu Glu Glu Thr Glu Asp Glu Asn Glu Leu Ile Ala Trp Leu Glu 
    450                 455                 460                 


Lys Glu Cys Ala Leu Asp Gly Ala Ala Ala Ala Arg Val Ala Asn Thr 
465                 470                 475                 480 


Thr Leu Pro Asp Gly His Cys Arg Leu Gly Leu Arg Ala Ile Lys Lys 
                485                 490                 495     


Ile Val Pro Ile Met Gln Asp Gly Leu Asp Glu Asp Gly Val Ala Gly 
            500                 505                 510         


Ala Gly Tyr His Ile Ala Ala Lys Arg Ala Gly Tyr Asp His Ala Lys 
        515                 520                 525             


Leu Pro Thr Gly Glu Gln Leu Gly Arg Leu Pro Tyr Tyr Gly Gln Trp 
    530                 535                 540                 


Leu Gln Asp Ala Val Val Gly Ser Gly Asp Ala Arg Asp Gln Lys Glu 
545                 550                 555                 560 


Lys Gln Tyr Gly Gln Phe Pro Asn Pro Thr Val His Ile Gly Leu Gly 
                565                 570                 575     


Gln Leu Arg Arg Val Val Asn Asp Leu Ile Asp Lys Tyr Gly Pro Pro 
            580                 585                 590         


Thr Glu Ile Ser Ile Glu Phe Thr Arg Ala Leu Lys Leu Ser Glu Gln 
        595                 600                 605             


Gln Lys Ala Glu Arg Gln Arg Glu Gln Arg Arg Asn Gln Asp Lys Asn 
    610                 615                 620                 


Lys Ala Arg Ala Glu Glu Leu Ala Lys Phe Gly Arg Pro Ala Asn Pro 
625                 630                 635                 640 


Arg Asn Leu Leu Lys Met Arg Leu Trp Glu Glu Leu Ala His Asp Pro 
                645                 650                 655     


Leu Asp Arg Lys Cys Val Tyr Thr Gly Glu Gln Ile Ser Ile Glu Arg 
            660                 665                 670         


Leu Leu Ser Asp Glu Val Asp Ile Asp His Ile Leu Pro Val Ala Met 
        675                 680                 685             


Thr Leu Asp Asp Ser Pro Ala Asn Lys Ile Ile Cys Met Arg Tyr Ala 
    690                 695                 700                 


Asn Arg His Lys Arg Lys Gln Thr Pro Ser Glu Ala Phe Gly Ser Ser 
705                 710                 715                 720 


Pro Thr Leu Gln Gly His Arg Tyr Asn Trp Asp Asp Ile Ala Ala Arg 
                725                 730                 735     


Ala Thr Gly Leu Pro Arg Asn Lys Arg Trp Arg Phe Asp Ala Asn Ala 
            740                 745                 750         


Arg Glu Glu Phe Asp Lys Arg Gly Gly Phe Leu Ala Arg Gln Leu Asn 
        755                 760                 765             


Glu Thr Gly Trp Leu Ala Arg Leu Ala Lys Gln Tyr Leu Gly Ala Val 
    770                 775                 780                 


Thr Asp Pro Asn Gln Ile Trp Val Val Pro Gly Arg Leu Thr Ser Met 
785                 790                 795                 800 


Leu Arg Gly Lys Trp Gly Leu Asn Gly Leu Leu Pro Ser Asp Asn Tyr 
                805                 810                 815     


Ala Gly Val Gln Asp Lys Ala Glu Glu Phe Leu Ala Ser Thr Asp Asp 
            820                 825                 830         


Met Glu Phe Ser Gly Val Lys Asn Arg Ala Asp His Arg His His Ala 
        835                 840                 845             


Ile Asp Gly Leu Val Thr Ala Leu Thr Asp Arg Ser Leu Leu Trp Lys 
    850                 855                 860                 


Met Ala Asn Ala Tyr Asp Glu Glu His Glu Lys Phe Val Ile Glu Pro 
865                 870                 875                 880 


Pro Trp Pro Thr Met Arg Asp Asp Leu Lys Ala Ala Leu Glu Lys Met 
                885                 890                 895     


Val Val Ser His Lys Pro Asp His Gly Ile Glu Gly Lys Leu His Glu 
            900                 905                 910         


Asp Ser Ala Tyr Gly Phe Val Lys Pro Leu Asp Ala Thr Gly Leu Lys 
        915                 920                 925             


Glu Glu Glu Ala Gly Asn Leu Val Tyr Arg Lys Ala Ile Glu Ser Leu 
    930                 935                 940                 


Asn Glu Asn Glu Val Asp Arg Ile Arg Asp Ile Gln Leu Arg Thr Ile 
945                 950                 955                 960 


Val Arg Asp His Val Asn Val Glu Lys Thr Lys Gly Val Ala Leu Ala 
                965                 970                 975     


Asp Ala Leu Arg Gln Leu Gln Ala Pro Ser Asp Asp Tyr Pro Gln Phe 
            980                 985                 990         


Lys His Gly Leu Arg His Val Arg  Ile Leu Lys Lys Glu  Lys Gly Asp 
        995                 1000                 1005             


Tyr Leu  Val Pro Ile Ala Asn  Arg Ala Ser Gly Val  Ala Tyr Lys 
    1010                 1015                 1020             


Ala Tyr  Ser Ala Gly Glu Asn  Phe Cys Val Glu Val  Phe Glu Thr 
    1025                 1030                 1035             


Ala Gly  Gly Lys Trp Asp Gly  Glu Ala Val Arg Arg  Phe Asp Ala 
    1040                 1045                 1050             


Asn Lys  Lys Asn Ala Gly Pro  Lys Ile Ala His Ala  Pro Gln Trp 
    1055                 1060                 1065             


Arg Asp  Ala Asn Glu Gly Ala  Lys Leu Val Met Arg  Ile His Lys 
    1070                 1075                 1080             


Gly Asp  Leu Ile Arg Leu Asp  His Glu Gly Arg Ala  Arg Ile Met 
    1085                 1090                 1095             


Val Val  His Arg Leu Asp Ala  Ala Ala Gly Arg Phe  Lys Leu Ala 
    1100                 1105                 1110             


Asp His  Asn Glu Thr Gly Asn  Leu Asp Lys Arg His  Ala Thr Asn 
    1115                 1120                 1125             


Asn Asp  Ile Asp Pro Phe Arg  Trp Leu Met Ala Ser  Tyr Asn Thr 
    1130                 1135                 1140             


Leu Lys  Lys Leu Ala Ala Val  Pro Val Arg Val Asp  Glu Leu Gly 
    1145                 1150                 1155             


Arg Val  Trp Arg Val Met Pro  Asn 
    1160                 1165     


<210> 368
<211> 1044
<212> PRT
<213> Nitrosomonas sp.


<220>
<223> Nitrosomonas sp. AL212

<400> 368
Met Leu His Lys Met Arg Tyr Arg Leu Ala Leu Asp Leu Gly Ser Thr 
1               5                   10                  15      


Ser Leu Gly Trp Ala Met Val Arg Leu Asn Ala Asn Gln Gln Pro Cys 
            20                  25                  30          


Ala Val Ile Lys Ala Gly Val Arg Ile Phe Ser Asn Gly Arg Asn Pro 
        35                  40                  45              


Lys Asp Gly Ser Ser Leu Ala Val Thr Arg Arg Glu Ala Arg Ser Met 
    50                  55                  60                  


Arg Arg Arg Arg Asp Arg Leu Leu Lys Arg Lys Ala Arg Met Met Arg 
65                  70                  75                  80  


Thr Leu Ile Glu Tyr Gly Phe Phe Pro Ala Asn Glu Thr Gln Arg Lys 
                85                  90                  95      


Ala Leu Glu Asn Leu Asn Pro Tyr Ala Leu Arg Ala Lys Gly Leu Asp 
            100                 105                 110         


Glu Ala Leu Thr Pro Ser Glu Phe Ala Arg Ala Leu Phe His Ile Asn 
        115                 120                 125             


Gln Arg Arg Gly Phe Lys Ser Asn Arg Lys Thr Asp Lys Lys Asp Ser 
    130                 135                 140                 


Asp Ser Gly Ala Leu Lys Thr Ala Ile Lys Gln Leu His Ser Val Leu 
145                 150                 155                 160 


Asp Pro Gln Gly Asn Asp Gly Lys Pro Arg Thr Val Gly Glu Leu Leu 
                165                 170                 175     


Tyr Lys Arg Phe Thr Asp Leu Ser Lys Leu Pro Lys Asp Arg Thr Val 
            180                 185                 190         


Arg Ala Arg Tyr Arg Gln Asp Lys Ile Val Lys Asp Asp Gly Lys Thr 
        195                 200                 205             


Lys Ile Asp Lys Tyr Tyr Asp Leu Tyr Ile Asp Arg Ala Met Ile Glu 
    210                 215                 220                 


Gln Glu Phe Asp Ala Leu Trp Lys Lys Gln Ser Glu Leu Asn Pro Ile 
225                 230                 235                 240 


Leu Phe Thr Glu Asn Ala Arg Ala Asp Leu Lys Asp Val Leu Leu Tyr 
                245                 250                 255     


Gln Arg Ser Leu Lys Pro Val Lys Pro Gly Arg Cys Thr Phe Met Ser 
            260                 265                 270         


Glu Glu Glu Arg Ala Pro Leu Ala Leu Pro Ser Thr Gln Arg Phe Arg 
        275                 280                 285             


Met Tyr Gln Glu Val Asn Asn Leu Arg Ile Leu Arg Glu Gly Leu Lys 
    290                 295                 300                 


Glu Glu Ser Leu Thr Leu Gln Gln Arg Asp Asp Leu Ile Asn Ala Leu 
305                 310                 315                 320 


Glu Lys Asn Asn Arg Arg Thr Phe Thr Gln Ile Lys Lys Leu Leu Gly 
                325                 330                 335     


Val Gly Gly Ser Val Gln Phe Asn Phe Glu Asp Pro Lys Arg Glu Glu 
            340                 345                 350         


Leu Lys Gly Asn Thr Thr Ser Ala Ile Leu Gly Lys Ser Glu His Phe 
        355                 360                 365             


Gly Glu Ala Trp Phe Ala Phe Asn Glu Ala Lys Gln Asp Ala Ile Val 
    370                 375                 380                 


Leu Gln Leu Ile Lys Glu Glu Asn Glu Ala Lys Leu Val Arg Trp Leu 
385                 390                 395                 400 


Gln Asp Glu Thr Gly Ile Asp Glu Lys Arg Ala Glu Val Ile Ala Asn 
                405                 410                 415     


Ala Gly Leu Pro Glu Gly Tyr Gly Ser Leu Cys Ile Glu Ala Leu Ala 
            420                 425                 430         


Arg Ile Leu Pro Glu Leu Arg Arg Asp Val Val Thr Tyr Asp Lys Ala 
        435                 440                 445             


Val Gln Ala Ala Gly Phe Glu His His Ser Lys Leu Asn Arg Asn Glu 
    450                 455                 460                 


Glu Ile Pro Asp Ile Thr Phe Lys Ile Glu Ser Ile Asp Arg Asn Ser 
465                 470                 475                 480 


Gly Glu Ile Lys Gln Phe His Leu His Lys Glu Leu Pro Tyr Tyr Gly 
                485                 490                 495     


Glu Tyr Leu Gln Arg His Val Gly Phe Gly Ser Gly Lys Pro Glu Asp 
            500                 505                 510         


Ser Ile Glu Lys Arg Tyr Gly Lys Ile Ala Asn Pro Thr Val His Ile 
        515                 520                 525             


Gly Leu Asn Gln Val Arg Val Val Val Asn Ala Leu Ile Lys Arg Tyr 
    530                 535                 540                 


Gly His Pro Ser Glu Ile Ile Val Glu Val Ala Arg Asp Leu Lys Gln 
545                 550                 555                 560 


Ser Lys Asp Arg Arg Asp Glu Glu Asn Lys Arg Gln Ala Glu Asn Gln 
                565                 570                 575     


Lys Arg Asn Glu Arg Leu Arg Lys Asp Ile Ala Asp Ile Leu Gly Ile 
            580                 585                 590         


Ser Glu Glu Arg Val Arg Arg Asp Asp Ile Glu Lys Met Ile Leu Trp 
        595                 600                 605             


Glu Glu Leu Ser Phe Asp Pro Ala Asp Arg Arg Cys Pro Tyr Ser Gly 
    610                 615                 620                 


Val Gln Val Ser Thr Val Met Leu Leu Ser Asp Glu Val Glu Val Glu 
625                 630                 635                 640 


His Ile Leu Pro Phe Ser Gln Thr Leu Asp Asp Ser Leu Asn Asn Lys 
                645                 650                 655     


Thr Val Ala Leu Arg Gln Ala Asn Arg Ile Lys Gly Asn Arg Thr Pro 
            660                 665                 670         


Trp Glu Ala Phe Gly Thr Ser Asn Ile Ser Gly Phe Asp Tyr Ser Gly 
        675                 680                 685             


Ile Leu Thr Arg Ala Glu Leu Met Pro Lys Ala Lys Arg Tyr Arg Phe 
    690                 695                 700                 


Ala Glu Asp Gly Tyr Gln Arg Trp Leu Lys Asp Asp Ala Gly Phe Leu 
705                 710                 715                 720 


Ala Arg Ala Leu Asn Asp Thr Arg His Leu Ser Lys Ile Ala Arg Glu 
                725                 730                 735     


Tyr Met Ser Leu Ile Cys Pro Asn Thr Arg Val Ile Pro Gly Gln Met 
            740                 745                 750         


Thr Ala Met Leu Arg Arg Asn Phe Gly Leu Asn Asp Val Leu Gly Leu 
        755                 760                 765             


Asn Gly Glu Lys Asn Arg Asn Asp His Arg His His Ala Val Asp Ala 
    770                 775                 780                 


Cys Val Ile Ala Val Thr Asp Gln Gly Leu Leu Gln Arg Phe Ala Ala 
785                 790                 795                 800 


Ala Ser Ala Ser Ala Arg Glu Arg Gln Leu Asn Arg Leu Val Glu Asn 
                805                 810                 815     


Met Pro Leu Pro Trp Glu Ser Tyr Arg Glu His Val Arg Arg Ala Ile 
            820                 825                 830         


Asp Gly Ile Trp Val Ser His Arg Pro Asp His Ser His Glu Gly Ala 
        835                 840                 845             


Met His Asn Asp Thr Ala Tyr Gly Leu Arg Gly Asn Gly Arg Val Ser 
    850                 855                 860                 


Phe His Lys Met Val Glu Gly Lys Arg Glu Tyr Ile Glu Asp Asn Leu 
865                 870                 875                 880 


Lys Val Ile Glu Ile Thr Asp Thr Lys Ala Ile Asp Arg His Gly Leu 
                885                 890                 895     


Leu Pro Thr Gly Lys Pro Arg Pro Tyr Lys Gly Tyr Lys Gly Asp Ser 
            900                 905                 910         


Asn Tyr Cys Ile Glu Ile Val Arg Asn Glu Lys Gly Arg Trp Glu Gly 
        915                 920                 925             


Glu Ile Ile Ser Thr Phe Asp Ala Tyr Gln Leu Val Arg Lys Tyr Gly 
    930                 935                 940                 


Ile Val Gln Leu Arg Tyr Pro Val Leu Ser Val Ser Gly Lys Pro Leu 
945                 950                 955                 960 


Val Met Arg Leu Ile Arg Asn Asp Phe Val Arg Leu Glu His Glu Gly 
                965                 970                 975     


Ile Thr Arg Thr Leu Arg Val Cys Lys Met Arg Glu Asp Gly Gln Val 
            980                 985                 990         


Ala Leu Ala Asp Val Thr Glu Ala  Asn Val Asp Ala Arg  Thr Arg Thr 
        995                 1000                 1005             


Lys Glu  Ile Cys Tyr Val Phe  Lys Thr Gly Gly Ser  Leu Gln Lys 
    1010                 1015                 1020             


Ala Lys  Ala Arg Arg Ile Thr  Ile Ser Pro Ile Gly  Glu Leu Arg 
    1025                 1030                 1035             


Asp Pro  Gly Phe Lys Glu 
    1040                 


<210> 369
<211> 1498
<212> PRT
<213> Odoribacter laneus


<220>
<223> Odoribacter laneus YIT 12061

<400> 369
Met Glu Thr Thr Leu Gly Ile Asp Leu Gly Thr Asn Ser Ile Gly Leu 
1               5                   10                  15      


Ala Leu Val Asp Gln Glu Glu His Gln Ile Leu Tyr Ser Gly Val Arg 
            20                  25                  30          


Ile Phe Pro Glu Gly Ile Asn Lys Asp Thr Ile Gly Leu Gly Glu Lys 
        35                  40                  45              


Glu Glu Ser Arg Asn Ala Thr Arg Arg Ala Lys Arg Gln Met Arg Arg 
    50                  55                  60                  


Gln Tyr Phe Arg Lys Lys Leu Arg Lys Ala Lys Leu Leu Glu Leu Leu 
65                  70                  75                  80  


Ile Ala Tyr Asp Met Cys Pro Leu Lys Pro Glu Asp Val Arg Arg Trp 
                85                  90                  95      


Lys Asn Trp Asp Lys Gln Gln Lys Ser Thr Val Arg Gln Phe Pro Asp 
            100                 105                 110         


Thr Pro Ala Phe Arg Glu Trp Leu Lys Gln Asn Pro Tyr Glu Leu Arg 
        115                 120                 125             


Lys Gln Ala Val Thr Glu Asp Val Thr Arg Pro Glu Leu Gly Arg Ile 
    130                 135                 140                 


Leu Tyr Gln Met Ile Gln Arg Arg Gly Phe Leu Ser Ser Arg Lys Gly 
145                 150                 155                 160 


Lys Glu Glu Gly Lys Ile Phe Thr Gly Lys Asp Arg Met Val Gly Ile 
                165                 170                 175     


Asp Glu Thr Arg Lys Asn Leu Gln Lys Gln Thr Leu Gly Ala Tyr Leu 
            180                 185                 190         


Tyr Asp Ile Ala Pro Lys Asn Gly Glu Lys Tyr Arg Phe Arg Thr Glu 
        195                 200                 205             


Arg Val Arg Ala Arg Tyr Thr Leu Arg Asp Met Tyr Ile Arg Glu Phe 
    210                 215                 220                 


Glu Ile Ile Trp Gln Arg Gln Ala Gly His Leu Gly Leu Ala His Glu 
225                 230                 235                 240 


Gln Ala Thr Arg Lys Lys Asn Ile Phe Leu Glu Gly Ser Ala Thr Asn 
                245                 250                 255     


Val Arg Asn Ser Lys Leu Ile Thr His Leu Gln Ala Lys Tyr Gly Arg 
            260                 265                 270         


Gly His Val Leu Ile Glu Asp Thr Arg Ile Thr Val Thr Phe Gln Leu 
        275                 280                 285             


Pro Leu Lys Glu Val Leu Gly Gly Lys Ile Glu Ile Glu Glu Glu Gln 
    290                 295                 300                 


Leu Lys Phe Lys Ser Asn Glu Ser Val Leu Phe Trp Gln Arg Pro Leu 
305                 310                 315                 320 


Arg Ser Gln Lys Ser Leu Leu Ser Lys Cys Val Phe Glu Gly Arg Asn 
                325                 330                 335     


Phe Tyr Asp Pro Val His Gln Lys Trp Ile Ile Ala Gly Pro Thr Pro 
            340                 345                 350         


Ala Pro Leu Ser His Pro Glu Phe Glu Glu Phe Arg Ala Tyr Gln Phe 
        355                 360                 365             


Ile Asn Asn Ile Ile Tyr Gly Lys Asn Glu His Leu Thr Ala Ile Gln 
    370                 375                 380                 


Arg Glu Ala Val Phe Glu Leu Met Cys Thr Glu Ser Lys Asp Phe Asn 
385                 390                 395                 400 


Phe Glu Lys Ile Pro Lys His Leu Lys Leu Phe Glu Lys Phe Asn Phe 
                405                 410                 415     


Asp Asp Thr Thr Lys Val Pro Ala Cys Thr Thr Ile Ser Gln Leu Arg 
            420                 425                 430         


Lys Leu Phe Pro His Pro Val Trp Glu Glu Lys Arg Glu Glu Ile Trp 
        435                 440                 445             


His Cys Phe Tyr Phe Tyr Asp Asp Asn Thr Leu Leu Phe Glu Lys Leu 
    450                 455                 460                 


Gln Lys Asp Tyr Ala Leu Gln Thr Asn Asp Leu Glu Lys Ile Lys Lys 
465                 470                 475                 480 


Ile Arg Leu Ser Glu Ser Tyr Gly Asn Val Ser Leu Lys Ala Ile Arg 
                485                 490                 495     


Arg Ile Asn Pro Tyr Leu Lys Lys Gly Tyr Ala Tyr Ser Thr Ala Val 
            500                 505                 510         


Leu Leu Gly Gly Ile Arg Asn Ser Phe Gly Lys Arg Phe Glu Tyr Phe 
        515                 520                 525             


Lys Glu Tyr Glu Pro Glu Ile Glu Lys Ala Val Cys Arg Ile Leu Lys 
    530                 535                 540                 


Glu Lys Asn Ala Glu Gly Glu Val Ile Arg Lys Ile Lys Asp Tyr Leu 
545                 550                 555                 560 


Val His Asn Arg Phe Gly Phe Ala Lys Asn Asp Arg Ala Phe Gln Lys 
                565                 570                 575     


Leu Tyr His His Ser Gln Ala Ile Thr Thr Gln Ala Gln Lys Glu Arg 
            580                 585                 590         


Leu Pro Glu Thr Gly Asn Leu Arg Asn Pro Ile Val Gln Gln Gly Leu 
        595                 600                 605             


Asn Glu Leu Arg Arg Thr Val Asn Lys Leu Leu Ala Thr Cys Arg Glu 
    610                 615                 620                 


Lys Tyr Gly Pro Ser Phe Lys Phe Asp His Ile His Val Glu Met Gly 
625                 630                 635                 640 


Arg Glu Leu Arg Ser Ser Lys Thr Glu Arg Glu Lys Gln Ser Arg Gln 
                645                 650                 655     


Ile Arg Glu Asn Glu Lys Lys Asn Glu Ala Ala Lys Val Lys Leu Ala 
            660                 665                 670         


Glu Tyr Gly Leu Lys Ala Tyr Arg Asp Asn Ile Gln Lys Tyr Leu Leu 
        675                 680                 685             


Tyr Lys Glu Ile Glu Glu Lys Gly Gly Thr Val Cys Cys Pro Tyr Thr 
    690                 695                 700                 


Gly Lys Thr Leu Asn Ile Ser His Thr Leu Gly Ser Asp Asn Ser Val 
705                 710                 715                 720 


Gln Ile Glu His Ile Ile Pro Tyr Ser Ile Ser Leu Asp Asp Ser Leu 
                725                 730                 735     


Ala Asn Lys Thr Leu Cys Asp Ala Thr Phe Asn Arg Glu Lys Gly Glu 
            740                 745                 750         


Leu Thr Pro Tyr Asp Phe Tyr Gln Lys Asp Pro Ser Pro Glu Lys Trp 
        755                 760                 765             


Gly Ala Ser Ser Trp Glu Glu Ile Glu Asp Arg Ala Phe Arg Leu Leu 
    770                 775                 780                 


Pro Tyr Ala Lys Ala Gln Arg Phe Ile Arg Arg Lys Pro Gln Glu Ser 
785                 790                 795                 800 


Asn Glu Phe Ile Ser Arg Gln Leu Asn Asp Thr Arg Tyr Ile Ser Lys 
                805                 810                 815     


Lys Ala Val Glu Tyr Leu Ser Ala Ile Cys Ser Asp Val Lys Ala Phe 
            820                 825                 830         


Pro Gly Gln Leu Thr Ala Glu Leu Arg His Leu Trp Gly Leu Asn Asn 
        835                 840                 845             


Ile Leu Gln Ser Ala Pro Asp Ile Thr Phe Pro Leu Pro Val Ser Ala 
    850                 855                 860                 


Thr Glu Asn His Arg Glu Tyr Tyr Val Ile Thr Asn Glu Gln Asn Glu 
865                 870                 875                 880 


Val Ile Arg Leu Phe Pro Lys Gln Gly Glu Thr Pro Arg Thr Glu Lys 
                885                 890                 895     


Gly Glu Leu Leu Leu Thr Gly Glu Val Glu Arg Lys Val Phe Arg Cys 
            900                 905                 910         


Lys Gly Met Gln Glu Phe Gln Thr Asp Val Ser Asp Gly Lys Tyr Trp 
        915                 920                 925             


Arg Arg Ile Lys Leu Ser Ser Ser Val Thr Trp Ser Pro Leu Phe Ala 
    930                 935                 940                 


Pro Lys Pro Ile Ser Ala Asp Gly Gln Ile Val Leu Lys Gly Arg Ile 
945                 950                 955                 960 


Glu Lys Gly Val Phe Val Cys Asn Gln Leu Lys Gln Lys Leu Lys Thr 
                965                 970                 975     


Gly Leu Pro Asp Gly Ser Tyr Trp Ile Ser Leu Pro Val Ile Ser Gln 
            980                 985                 990         


Thr Phe Lys Glu Gly Glu Ser Val  Asn Asn Ser Lys Leu  Thr Ser Gln 
        995                 1000                 1005             


Gln Val  Gln Leu Phe Gly Arg  Val Arg Glu Gly Ile  Phe Arg Cys 
    1010                 1015                 1020             


His Asn  Tyr Gln Cys Pro Ala  Ser Gly Ala Asp Gly  Asn Phe Trp 
    1025                 1030                 1035             


Cys Thr  Leu Asp Thr Asp Thr  Ala Gln Pro Ala Phe  Thr Pro Ile 
    1040                 1045                 1050             


Lys Asn  Ala Pro Pro Gly Val  Gly Gly Gly Gln Ile  Ile Leu Thr 
    1055                 1060                 1065             


Gly Asp  Val Asp Asp Lys Gly  Ile Phe His Ala Asp  Asp Asp Leu 
    1070                 1075                 1080             


His Tyr  Glu Leu Pro Ala Ser  Leu Pro Lys Gly Lys  Tyr Tyr Gly 
    1085                 1090                 1095             


Ile Phe  Thr Val Glu Ser Cys  Asp Pro Thr Leu Ile  Pro Ile Glu 
    1100                 1105                 1110             


Leu Ser  Ala Pro Lys Thr Ser  Lys Gly Glu Asn Leu  Ile Glu Gly 
    1115                 1120                 1125             


Asn Ile  Trp Val Asp Glu His  Thr Gly Glu Val Arg  Phe Asp Pro 
    1130                 1135                 1140             


Lys Lys  Asn Arg Glu Asp Gln  Arg His His Ala Ile  Asp Ala Ile 
    1145                 1150                 1155             


Val Ile  Ala Leu Ser Ser Gln  Ser Leu Phe Gln Arg  Leu Ser Thr 
    1160                 1165                 1170             


Tyr Asn  Ala Arg Arg Glu Asn  Lys Lys Arg Gly Leu  Asp Ser Thr 
    1175                 1180                 1185             


Glu His  Phe Pro Ser Pro Trp  Pro Gly Phe Ala Gln  Asp Val Arg 
    1190                 1195                 1200             


Gln Ser  Val Val Pro Leu Leu  Val Ser Tyr Lys Gln  Asn Pro Lys 
    1205                 1210                 1215             


Thr Leu  Cys Lys Ile Ser Lys  Thr Leu Tyr Lys Asp  Gly Lys Lys 
    1220                 1225                 1230             


Ile His  Ser Cys Gly Asn Ala  Val Arg Gly Gln Leu  His Lys Glu 
    1235                 1240                 1245             


Thr Val  Tyr Gly Gln Arg Thr  Ala Pro Gly Ala Thr  Glu Lys Ser 
    1250                 1255                 1260             


Tyr His  Ile Arg Lys Asp Ile  Arg Glu Leu Lys Thr  Ser Lys His 
    1265                 1270                 1275             


Ile Gly  Lys Val Val Asp Ile  Thr Ile Arg Gln Met  Leu Leu Lys 
    1280                 1285                 1290             


His Leu  Gln Glu Asn Tyr His  Ile Asp Ile Thr Gln  Glu Phe Asn 
    1295                 1300                 1305             


Ile Pro  Ser Asn Ala Phe Phe  Lys Glu Gly Val Tyr  Arg Ile Phe 
    1310                 1315                 1320             


Leu Pro  Asn Lys His Gly Glu  Pro Val Pro Ile Lys  Lys Ile Arg 
    1325                 1330                 1335             


Met Lys  Glu Glu Leu Gly Asn  Ala Glu Arg Leu Lys  Asp Asn Ile 
    1340                 1345                 1350             


Asn Gln  Tyr Val Asn Pro Arg  Asn Asn His His Val  Met Ile Tyr 
    1355                 1360                 1365             


Gln Asp  Ala Asp Gly Asn Leu  Lys Glu Glu Ile Val  Ser Phe Trp 
    1370                 1375                 1380             


Ser Val  Ile Glu Arg Gln Asn  Gln Gly Gln Pro Ile  Tyr Gln Leu 
    1385                 1390                 1395             


Pro Arg  Glu Gly Arg Asn Ile  Val Ser Ile Leu Gln  Ile Asn Asp 
    1400                 1405                 1410             


Thr Phe  Leu Ile Gly Leu Lys  Glu Glu Glu Pro Glu  Val Tyr Arg 
    1415                 1420                 1425             


Asn Asp  Leu Ser Thr Leu Ser  Lys His Leu Tyr Arg  Val Gln Lys 
    1430                 1435                 1440             


Leu Ser  Gly Met Tyr Tyr Thr  Phe Arg His His Leu  Ala Ser Thr 
    1445                 1450                 1455             


Leu Asn  Asn Glu Arg Glu Glu  Phe Arg Ile Gln Ser  Leu Glu Ala 
    1460                 1465                 1470             


Trp Lys  Arg Ala Asn Pro Val  Lys Val Gln Ile Asp  Glu Ile Gly 
    1475                 1480                 1485             


Arg Ile  Thr Phe Leu Asn Gly  Pro Leu Cys 
    1490                 1495             


<210> 370
<211> 1389
<212> PRT
<213> Oenococcus kitaharae


<220>
<223> Oenococcus kitaharae DSM 17330

<400> 370
Met Ala Arg Asp Tyr Ser Val Gly Leu Asp Ile Gly Thr Ser Ser Val 
1               5                   10                  15      


Gly Trp Ala Ala Ile Asp Asn Lys Tyr His Leu Ile Arg Ala Lys Ser 
            20                  25                  30          


Lys Asn Leu Ile Gly Val Arg Leu Phe Asp Ser Ala Val Thr Ala Glu 
        35                  40                  45              


Lys Arg Arg Gly Tyr Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg His 
    50                  55                  60                  


Trp Arg Leu Arg Leu Leu Asn Asp Ile Phe Ala Gly Pro Leu Thr Asp 
65                  70                  75                  80  


Phe Gly Asp Glu Asn Phe Leu Ala Arg Leu Lys Tyr Ser Trp Val His 
                85                  90                  95      


Pro Gln Asp Gln Ser Asn Gln Ala His Phe Ala Ala Gly Leu Leu Phe 
            100                 105                 110         


Asp Ser Lys Glu Gln Asp Lys Asp Phe Tyr Arg Lys Tyr Pro Thr Ile 
        115                 120                 125             


Tyr His Leu Arg Leu Ala Leu Met Asn Asp Asp Gln Lys His Asp Leu 
    130                 135                 140                 


Arg Glu Val Tyr Leu Ala Ile His His Leu Val Lys Tyr Arg Gly His 
145                 150                 155                 160 


Phe Leu Ile Glu Gly Asp Val Lys Ala Asp Ser Ala Phe Asp Val His 
                165                 170                 175     


Thr Phe Ala Asp Ala Ile Gln Arg Tyr Ala Glu Ser Asn Asn Ser Asp 
            180                 185                 190         


Glu Asn Leu Leu Gly Lys Ile Asp Glu Lys Lys Leu Ser Ala Ala Leu 
        195                 200                 205             


Thr Asp Lys His Gly Ser Lys Ser Gln Arg Ala Glu Thr Ala Glu Thr 
    210                 215                 220                 


Ala Phe Asp Ile Leu Asp Leu Gln Ser Lys Lys Gln Ile Gln Ala Ile 
225                 230                 235                 240 


Leu Lys Ser Val Val Gly Asn Gln Ala Asn Leu Met Ala Ile Phe Gly 
                245                 250                 255     


Leu Asp Ser Ser Ala Ile Ser Lys Asp Glu Gln Lys Asn Tyr Lys Phe 
            260                 265                 270         


Ser Phe Asp Asp Ala Asp Ile Asp Glu Lys Ile Ala Asp Ser Glu Ala 
        275                 280                 285             


Leu Leu Ser Asp Thr Glu Phe Glu Phe Leu Cys Asp Leu Lys Ala Ala 
    290                 295                 300                 


Phe Asp Gly Leu Thr Leu Lys Met Leu Leu Gly Asp Asp Lys Thr Val 
305                 310                 315                 320 


Ser Ala Ala Met Val Arg Arg Phe Asn Glu His Gln Lys Asp Trp Glu 
                325                 330                 335     


Tyr Ile Lys Ser His Ile Arg Asn Ala Lys Asn Ala Gly Asn Gly Leu 
            340                 345                 350         


Tyr Glu Lys Ser Lys Lys Phe Asp Gly Ile Asn Ala Ala Tyr Leu Ala 
        355                 360                 365             


Leu Gln Ser Asp Asn Glu Asp Asp Arg Lys Lys Ala Lys Lys Ile Phe 
    370                 375                 380                 


Gln Asp Glu Ile Ser Ser Ala Asp Ile Pro Asp Asp Val Lys Ala Asp 
385                 390                 395                 400 


Phe Leu Lys Lys Ile Asp Asp Asp Gln Phe Leu Pro Ile Gln Arg Thr 
                405                 410                 415     


Lys Asn Asn Gly Thr Ile Pro His Gln Leu His Arg Asn Glu Leu Glu 
            420                 425                 430         


Gln Ile Ile Glu Lys Gln Gly Ile Tyr Tyr Pro Phe Leu Lys Asp Thr 
        435                 440                 445             


Tyr Gln Glu Asn Ser His Glu Leu Asn Lys Ile Thr Ala Leu Ile Asn 
    450                 455                 460                 


Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Val Glu Glu Glu Gln Lys 
465                 470                 475                 480 


Ile Ala Asp Asp Gly Lys Asn Ile Pro Asp Pro Thr Asn His Trp Met 
                485                 490                 495     


Val Arg Lys Ser Asn Asp Thr Ile Thr Pro Trp Asn Leu Ser Gln Val 
            500                 505                 510         


Val Asp Leu Asp Lys Ser Gly Arg Arg Phe Ile Glu Arg Leu Thr Gly 
        515                 520                 525             


Thr Asp Thr Tyr Leu Ile Gly Glu Pro Thr Leu Pro Lys Asn Ser Leu 
    530                 535                 540                 


Leu Tyr Gln Lys Phe Asp Val Leu Gln Glu Leu Asn Asn Ile Arg Val 
545                 550                 555                 560 


Ser Gly Arg Arg Leu Asp Ile Arg Ala Lys Gln Asp Ala Phe Glu His 
                565                 570                 575     


Leu Phe Lys Val Gln Lys Thr Val Ser Ala Thr Asn Leu Lys Asp Phe 
            580                 585                 590         


Leu Val Gln Ala Gly Tyr Ile Ser Glu Asp Thr Gln Ile Glu Gly Leu 
        595                 600                 605             


Ala Asp Val Asn Gly Lys Asn Phe Asn Asn Ala Leu Thr Thr Tyr Asn 
    610                 615                 620                 


Tyr Leu Val Ser Val Leu Gly Arg Glu Phe Val Glu Asn Pro Ser Asn 
625                 630                 635                 640 


Glu Glu Leu Leu Glu Glu Ile Thr Glu Leu Gln Thr Val Phe Glu Asp 
                645                 650                 655     


Lys Lys Val Leu Arg Arg Gln Leu Asp Gln Leu Asp Gly Leu Ser Asp 
            660                 665                 670         


His Asn Arg Glu Lys Leu Ser Arg Lys His Tyr Thr Gly Trp Gly Arg 
        675                 680                 685             


Ile Ser Lys Lys Leu Leu Thr Thr Lys Ile Val Gln Asn Ala Asp Lys 
    690                 695                 700                 


Ile Asp Asn Gln Thr Phe Asp Val Pro Arg Met Asn Gln Ser Ile Ile 
705                 710                 715                 720 


Asp Thr Leu Tyr Asn Thr Lys Met Asn Leu Met Glu Ile Ile Asn Asn 
                725                 730                 735     


Ala Glu Asp Asp Phe Gly Val Arg Ala Trp Ile Asp Lys Gln Asn Thr 
            740                 745                 750         


Thr Asp Gly Asp Glu Gln Asp Val Tyr Ser Leu Ile Asp Glu Leu Ala 
        755                 760                 765             


Gly Pro Lys Glu Ile Lys Arg Gly Ile Val Gln Ser Phe Arg Ile Leu 
    770                 775                 780                 


Asp Asp Ile Thr Lys Ala Val Gly Tyr Ala Pro Lys Arg Val Tyr Leu 
785                 790                 795                 800 


Glu Phe Ala Arg Lys Thr Gln Glu Ser His Leu Thr Asn Ser Arg Lys 
                805                 810                 815     


Asn Gln Leu Ser Thr Leu Leu Lys Asn Ala Gly Leu Ser Glu Leu Val 
            820                 825                 830         


Thr Gln Val Ser Gln Tyr Asp Ala Ala Ala Leu Gln Asn Asp Arg Leu 
        835                 840                 845             


Tyr Leu Tyr Phe Leu Gln Gln Gly Lys Asp Met Tyr Ser Gly Glu Lys 
    850                 855                 860                 


Leu Asn Leu Asp Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Ile Pro 
865                 870                 875                 880 


Gln Ala Tyr Thr Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val Ser 
                885                 890                 895     


Asn Ile Thr Asn Arg Arg Lys Ser Asp Ser Ser Asn Tyr Leu Pro Ala 
            900                 905                 910         


Leu Ile Asp Lys Met Arg Pro Phe Trp Ser Val Leu Ser Lys Gln Gly 
        915                 920                 925             


Leu Leu Ser Lys His Lys Phe Ala Asn Leu Thr Arg Thr Arg Asp Phe 
    930                 935                 940                 


Asp Asp Met Glu Lys Glu Arg Phe Ile Ala Arg Ser Leu Val Glu Thr 
945                 950                 955                 960 


Arg Gln Ile Ile Lys Asn Val Ala Ser Leu Ile Asp Ser His Phe Gly 
                965                 970                 975     


Gly Glu Thr Lys Ala Val Ala Ile Arg Ser Ser Leu Thr Ala Asp Met 
            980                 985                 990         


Arg Arg Tyr Val Asp Ile Pro Lys  Asn Arg Asp Ile Asn  Asp Tyr His 
        995                 1000                 1005             


His Ala  Phe Asp Ala Leu Leu  Phe Ser Thr Val Gly  Gln Tyr Thr 
    1010                 1015                 1020             


Glu Asn  Ser Gly Leu Met Lys  Lys Gly Gln Leu Ser  Asp Ser Ala 
    1025                 1030                 1035             


Gly Asn  Gln Tyr Asn Arg Tyr  Ile Lys Glu Trp Ile  His Ala Ala 
    1040                 1045                 1050             


Arg Leu  Asn Ala Gln Ser Gln  Arg Val Asn Pro Phe  Gly Phe Val 
    1055                 1060                 1065             


Val Gly  Ser Met Arg Asn Ala  Ala Pro Gly Lys Leu  Asn Pro Glu 
    1070                 1075                 1080             


Thr Gly  Glu Ile Thr Pro Glu  Glu Asn Ala Asp Trp  Ser Ile Ala 
    1085                 1090                 1095             


Asp Leu  Asp Tyr Leu His Lys  Val Met Asn Phe Arg  Lys Ile Thr 
    1100                 1105                 1110             


Val Thr  Arg Arg Leu Lys Asp  Gln Lys Gly Gln Leu  Tyr Asp Glu 
    1115                 1120                 1125             


Ser Arg  Tyr Pro Ser Val Leu  His Asp Ala Lys Ser  Lys Ala Ser 
    1130                 1135                 1140             


Ile Asn  Phe Asp Lys His Lys  Pro Val Asp Leu Tyr  Gly Gly Phe 
    1145                 1150                 1155             


Ser Ser  Ala Lys Pro Ala Tyr  Ala Ala Leu Ile Lys  Phe Lys Asn 
    1160                 1165                 1170             


Lys Phe  Arg Leu Val Asn Val  Leu Arg Gln Trp Thr  Tyr Ser Asp 
    1175                 1180                 1185             


Lys Asn  Ser Glu Asp Tyr Ile  Leu Glu Gln Ile Arg  Gly Lys Tyr 
    1190                 1195                 1200             


Pro Lys  Ala Glu Met Val Leu  Ser His Ile Pro Tyr  Gly Gln Leu 
    1205                 1210                 1215             


Val Lys  Lys Asp Gly Ala Leu  Val Thr Ile Ser Ser  Ala Thr Glu 
    1220                 1225                 1230             


Leu His  Asn Phe Glu Gln Leu  Trp Leu Pro Leu Ala  Asp Tyr Lys 
    1235                 1240                 1245             


Leu Ile  Asn Thr Leu Leu Lys  Thr Lys Glu Asp Asn  Leu Val Asp 
    1250                 1255                 1260             


Ile Leu  His Asn Arg Leu Asp  Leu Pro Glu Met Thr  Ile Glu Ser 
    1265                 1270                 1275             


Ala Phe  Tyr Lys Ala Phe Asp  Ser Ile Leu Ser Phe  Ala Phe Asn 
    1280                 1285                 1290             


Arg Tyr  Ala Leu His Gln Asn  Ala Leu Val Lys Leu  Gln Ala His 
    1295                 1300                 1305             


Arg Asp  Asp Phe Asn Ala Leu  Asn Tyr Glu Asp Lys  Gln Gln Thr 
    1310                 1315                 1320             


Leu Glu  Arg Ile Leu Asp Ala  Leu His Ala Ser Pro  Ala Ser Ser 
    1325                 1330                 1335             


Asp Leu  Lys Lys Ile Asn Leu  Ser Ser Gly Phe Gly  Arg Leu Phe 
    1340                 1345                 1350             


Ser Pro  Ser His Phe Thr Leu  Ala Asp Thr Asp Glu  Phe Ile Phe 
    1355                 1360                 1365             


Gln Ser  Val Thr Gly Leu Phe  Ser Thr Gln Lys Thr  Val Ala Gln 
    1370                 1375                 1380             


Leu Tyr  Gln Glu Thr Lys 
    1385                 


<210> 371
<211> 1389
<212> PRT
<213> Oenococcus kitaharae


<220>
<223> Oenococcus kitaharae DSM 17330

<400> 371
Met Ala Arg Asp Tyr Ser Val Gly Leu Asp Ile Gly Thr Ser Ser Val 
1               5                   10                  15      


Gly Trp Ala Ala Ile Asp Asn Lys Tyr His Leu Ile Arg Ala Lys Ser 
            20                  25                  30          


Lys Asn Leu Ile Gly Val Arg Leu Phe Asp Ser Ala Val Thr Ala Glu 
        35                  40                  45              


Lys Arg Arg Gly Tyr Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg His 
    50                  55                  60                  


Trp Arg Leu Arg Leu Leu Asn Asp Ile Phe Ala Gly Pro Leu Thr Asp 
65                  70                  75                  80  


Phe Gly Asp Glu Asn Phe Leu Ala Arg Leu Lys Tyr Ser Trp Val His 
                85                  90                  95      


Pro Gln Asp Gln Ser Asn Gln Ala His Phe Ala Ala Gly Leu Leu Phe 
            100                 105                 110         


Asp Ser Lys Glu Gln Asp Lys Asp Phe Tyr Arg Lys Tyr Pro Thr Ile 
        115                 120                 125             


Tyr His Leu Arg Leu Ala Leu Met Asn Asp Asp Gln Lys His Asp Leu 
    130                 135                 140                 


Arg Glu Val Tyr Leu Ala Ile His His Leu Val Lys Tyr Arg Gly His 
145                 150                 155                 160 


Phe Leu Ile Glu Gly Asp Val Lys Ala Asp Ser Ala Phe Asp Val His 
                165                 170                 175     


Thr Phe Ala Asp Ala Ile Gln Arg Tyr Ala Glu Ser Asn Asn Ser Asp 
            180                 185                 190         


Glu Asn Leu Leu Gly Lys Ile Asp Glu Lys Lys Leu Ser Ala Ala Leu 
        195                 200                 205             


Thr Asp Lys His Gly Ser Lys Ser Gln Arg Ala Glu Thr Ala Glu Thr 
    210                 215                 220                 


Ala Phe Asp Ile Leu Asp Leu Gln Ser Lys Lys Gln Ile Gln Ala Ile 
225                 230                 235                 240 


Leu Lys Ser Val Val Gly Asn Gln Ala Asn Leu Met Ala Ile Phe Gly 
                245                 250                 255     


Leu Asp Ser Ser Ala Ile Ser Lys Asp Glu Gln Lys Asn Tyr Lys Phe 
            260                 265                 270         


Ser Phe Asp Asp Ala Asp Ile Asp Glu Lys Ile Ala Asp Ser Glu Ala 
        275                 280                 285             


Leu Leu Ser Asp Thr Glu Phe Glu Phe Leu Cys Asp Leu Lys Ala Ala 
    290                 295                 300                 


Phe Asp Gly Leu Thr Leu Lys Met Leu Leu Gly Asp Asp Lys Thr Val 
305                 310                 315                 320 


Ser Ala Ala Met Val Arg Arg Phe Asn Glu His Gln Lys Asp Trp Glu 
                325                 330                 335     


Tyr Ile Lys Ser His Ile Arg Asn Ala Lys Asn Ala Gly Asn Gly Leu 
            340                 345                 350         


Tyr Glu Lys Ser Lys Lys Phe Asp Gly Ile Asn Ala Ala Tyr Leu Ala 
        355                 360                 365             


Leu Gln Ser Asp Asn Glu Asp Asp Arg Lys Lys Ala Lys Lys Ile Phe 
    370                 375                 380                 


Gln Asp Glu Ile Ser Ser Ala Asp Ile Pro Asp Asp Val Lys Ala Asp 
385                 390                 395                 400 


Phe Leu Lys Lys Ile Asp Asp Asp Gln Phe Leu Pro Ile Gln Arg Thr 
                405                 410                 415     


Lys Asn Asn Gly Thr Ile Pro His Gln Leu His Arg Asn Glu Leu Glu 
            420                 425                 430         


Gln Ile Ile Glu Lys Gln Gly Ile Tyr Tyr Pro Phe Leu Lys Asp Thr 
        435                 440                 445             


Tyr Gln Glu Asn Ser His Glu Leu Asn Lys Ile Thr Ala Leu Ile Asn 
    450                 455                 460                 


Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Val Glu Glu Glu Gln Lys 
465                 470                 475                 480 


Ile Ala Asp Asp Gly Lys Asn Ile Pro Asp Pro Thr Asn His Trp Met 
                485                 490                 495     


Val Arg Lys Ser Asn Asp Thr Ile Thr Pro Trp Asn Leu Ser Gln Val 
            500                 505                 510         


Val Asp Leu Asp Lys Ser Gly Arg Arg Phe Ile Glu Arg Leu Thr Gly 
        515                 520                 525             


Thr Asp Thr Tyr Leu Ile Gly Glu Pro Thr Leu Pro Lys Asn Ser Leu 
    530                 535                 540                 


Leu Tyr Gln Lys Phe Asp Val Leu Gln Glu Leu Asn Asn Ile Arg Val 
545                 550                 555                 560 


Ser Gly Arg Arg Leu Asp Ile Arg Ala Lys Gln Asp Ala Phe Glu His 
                565                 570                 575     


Leu Phe Lys Val Gln Lys Thr Val Ser Ala Thr Asn Leu Lys Asp Phe 
            580                 585                 590         


Leu Val Gln Ala Gly Tyr Ile Ser Glu Asp Thr Gln Ile Glu Gly Leu 
        595                 600                 605             


Ala Asp Val Asn Gly Lys Asn Phe Asn Asn Ala Leu Thr Thr Tyr Asn 
    610                 615                 620                 


Tyr Leu Val Ser Val Leu Gly Arg Glu Phe Val Glu Asn Pro Ser Asn 
625                 630                 635                 640 


Glu Glu Leu Leu Glu Glu Ile Thr Glu Leu Gln Thr Val Phe Glu Asp 
                645                 650                 655     


Lys Lys Val Leu Arg Arg Gln Leu Asp Gln Leu Asp Gly Leu Ser Asp 
            660                 665                 670         


His Asn Arg Glu Lys Leu Ser Arg Lys His Tyr Thr Gly Trp Gly Arg 
        675                 680                 685             


Ile Ser Lys Lys Leu Leu Thr Thr Lys Ile Val Gln Asn Ala Asp Lys 
    690                 695                 700                 


Ile Asp Asn Gln Thr Phe Asp Val Pro Arg Met Asn Gln Ser Ile Ile 
705                 710                 715                 720 


Asp Thr Leu Tyr Asn Thr Lys Met Asn Leu Met Glu Ile Ile Asn Asn 
                725                 730                 735     


Ala Glu Asp Asp Phe Gly Val Arg Ala Trp Ile Asp Lys Gln Asn Thr 
            740                 745                 750         


Thr Asp Gly Asp Glu Gln Asp Val Tyr Ser Leu Ile Asp Glu Leu Ala 
        755                 760                 765             


Gly Pro Lys Glu Ile Lys Arg Gly Ile Val Gln Ser Phe Arg Ile Leu 
    770                 775                 780                 


Asp Asp Ile Thr Lys Ala Val Gly Tyr Ala Pro Lys Arg Val Tyr Leu 
785                 790                 795                 800 


Glu Phe Ala Arg Lys Thr Gln Glu Ser His Leu Thr Asn Ser Arg Lys 
                805                 810                 815     


Asn Gln Leu Ser Thr Leu Leu Lys Asn Ala Gly Leu Ser Glu Leu Val 
            820                 825                 830         


Thr Gln Val Ser Gln Tyr Asp Ala Ala Ala Leu Gln Asn Asp Arg Leu 
        835                 840                 845             


Tyr Leu Tyr Phe Leu Gln Gln Gly Lys Asp Met Tyr Ser Gly Glu Lys 
    850                 855                 860                 


Leu Asn Leu Asp Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Ile Pro 
865                 870                 875                 880 


Gln Ala Tyr Thr Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val Ser 
                885                 890                 895     


Asn Ile Thr Asn Arg Arg Lys Ser Asp Ser Ser Asn Tyr Leu Pro Ala 
            900                 905                 910         


Leu Ile Asp Lys Met Arg Pro Phe Trp Ser Val Leu Ser Lys Gln Gly 
        915                 920                 925             


Leu Leu Ser Lys His Lys Phe Ala Asn Leu Thr Arg Thr Arg Asp Phe 
    930                 935                 940                 


Asp Asp Met Glu Lys Glu Arg Phe Ile Ala Arg Ser Leu Val Glu Thr 
945                 950                 955                 960 


Arg Gln Ile Ile Lys Asn Val Ala Ser Leu Ile Asp Ser His Phe Gly 
                965                 970                 975     


Gly Glu Thr Lys Ala Val Ala Ile Arg Ser Ser Leu Thr Ala Asp Met 
            980                 985                 990         


Arg Arg Tyr Val Asp Ile Pro Lys  Asn Arg Asp Ile Asn  Asp Tyr His 
        995                 1000                 1005             


His Ala  Phe Asp Ala Leu Leu  Phe Ser Thr Val Gly  Gln Tyr Thr 
    1010                 1015                 1020             


Glu Asn  Ser Gly Leu Met Lys  Lys Gly Gln Leu Ser  Asp Ser Ala 
    1025                 1030                 1035             


Gly Asn  Gln Tyr Asn Arg Tyr  Ile Lys Glu Trp Ile  His Ala Ala 
    1040                 1045                 1050             


Arg Leu  Asn Ala Gln Ser Gln  Arg Val Asn Pro Phe  Gly Phe Val 
    1055                 1060                 1065             


Val Gly  Ser Met Arg Asn Ala  Ala Pro Gly Lys Leu  Asn Pro Glu 
    1070                 1075                 1080             


Thr Gly  Glu Ile Thr Pro Glu  Glu Asn Ala Asp Trp  Ser Ile Ala 
    1085                 1090                 1095             


Asp Leu  Asp Tyr Leu His Lys  Val Met Asn Phe Arg  Lys Ile Thr 
    1100                 1105                 1110             


Val Thr  Arg Arg Leu Lys Asp  Gln Lys Gly Gln Leu  Tyr Asp Glu 
    1115                 1120                 1125             


Ser Arg  Tyr Pro Ser Val Leu  His Asp Ala Lys Ser  Lys Ala Ser 
    1130                 1135                 1140             


Ile Asn  Phe Asp Lys His Lys  Pro Val Asp Leu Tyr  Gly Gly Phe 
    1145                 1150                 1155             


Ser Ser  Ala Lys Pro Ala Tyr  Ala Ala Leu Ile Lys  Phe Lys Asn 
    1160                 1165                 1170             


Lys Phe  Arg Leu Val Asn Val  Leu Arg Gln Trp Thr  Tyr Ser Asp 
    1175                 1180                 1185             


Lys Asn  Ser Glu Asp Tyr Ile  Leu Glu Gln Ile Arg  Gly Lys Tyr 
    1190                 1195                 1200             


Pro Lys  Ala Glu Met Val Leu  Ser His Ile Pro Tyr  Gly Gln Leu 
    1205                 1210                 1215             


Val Lys  Lys Asp Gly Ala Leu  Val Thr Ile Ser Ser  Ala Thr Glu 
    1220                 1225                 1230             


Leu His  Asn Phe Glu Gln Leu  Trp Leu Pro Leu Ala  Asp Tyr Lys 
    1235                 1240                 1245             


Leu Ile  Asn Thr Leu Leu Lys  Thr Lys Glu Asp Asn  Leu Val Asp 
    1250                 1255                 1260             


Ile Leu  His Asn Arg Leu Asp  Leu Pro Glu Met Thr  Ile Glu Ser 
    1265                 1270                 1275             


Ala Phe  Tyr Lys Ala Phe Asp  Ser Ile Leu Ser Phe  Ala Phe Asn 
    1280                 1285                 1290             


Arg Tyr  Ala Leu His Gln Asn  Ala Leu Val Lys Leu  Gln Ala His 
    1295                 1300                 1305             


Arg Asp  Asp Phe Asn Ala Leu  Asn Tyr Glu Asp Lys  Gln Gln Thr 
    1310                 1315                 1320             


Leu Glu  Arg Ile Leu Asp Ala  Leu His Ala Ser Pro  Ala Ser Ser 
    1325                 1330                 1335             


Asp Leu  Lys Lys Ile Asn Leu  Ser Ser Gly Phe Gly  Arg Leu Phe 
    1340                 1345                 1350             


Ser Pro  Ser His Phe Thr Leu  Ala Asp Thr Asp Glu  Phe Ile Phe 
    1355                 1360                 1365             


Gln Ser  Val Thr Gly Leu Phe  Ser Thr Gln Lys Thr  Val Ala Gln 
    1370                 1375                 1380             


Leu Tyr  Gln Glu Thr Lys 
    1385                 


<210> 372
<211> 1399
<212> PRT
<213> Olsenella uli

<400> 372
Met Asn Leu Arg Asn Thr Thr Asp Glu Tyr Asn Ile Gly Leu Asp Met 
1               5                   10                  15      


Gly Thr Asn Ser Val Gly Trp Ala Val Thr Asp Lys Ala Gly Ala Ile 
            20                  25                  30          


Ala His Phe Lys Gly Lys Pro Thr Leu Gly Ser Arg Leu Phe Asp Ala 
        35                  40                  45              


Ala Gln Thr Ala Ala Gly Ala Arg Ile His Arg Ser Gln Arg Arg Arg 
    50                  55                  60                  


Tyr Val Arg Arg Arg Trp Arg Leu Asp Leu Leu Gln Ser Leu Phe Gln 
65                  70                  75                  80  


Asp Glu Val Ser Lys Val Asp Ser Glu Phe Phe Cys Arg Leu Arg Gln 
                85                  90                  95      


Ser Arg Leu Tyr Val Gly Asp Arg Glu Lys Gly His Ala Asp Tyr Thr 
            100                 105                 110         


Trp Pro Ile Phe Asn Asp Ser Asp Phe Asn Glu Val Asp Tyr Tyr Lys 
        115                 120                 125             


Arg Phe Pro Thr Ile Tyr His Leu Arg Lys Trp Leu Met Glu Thr Asp 
    130                 135                 140                 


Glu Lys Ala Asp Ile Arg Leu Ile Tyr Leu Ala Thr His Asn Ile Val 
145                 150                 155                 160 


Lys His Arg Gly Asn Phe Leu Arg Glu Asn Asn Lys Ser Leu Ser Ser 
                165                 170                 175     


Arg Asp Ala Asn Pro Ala Gln Ala Val Lys Ser Leu Arg Leu Ala Leu 
            180                 185                 190         


Asn Asp Trp Cys Ser Glu Arg Asp Tyr Glu Cys Ala Trp Lys Gly Glu 
        195                 200                 205             


Glu Asp Asp Gly Ala Ile Asp Glu Ala Ile Leu Asn Val Leu Ala Asp 
    210                 215                 220                 


Gly Glu Lys Gly Arg Ser Asp Gln Ala Lys Glu Ile Ala Lys Leu Thr 
225                 230                 235                 240 


Gly Val Asp Cys Gly Asp Ala Lys Gln Ser Lys Gln Cys Asn Glu Ala 
                245                 250                 255     


Ile Ala Lys Ala Ile Val Gly Leu Lys Val Glu Met Lys Asn Ile Phe 
            260                 265                 270         


Gly Glu Phe Pro Ala Glu Lys Thr Ser Tyr Ile Tyr Leu Ser Ser Asp 
        275                 280                 285             


Glu Asp Val Glu Ala Val Arg Glu Ser Cys Pro Asp Asp Ser Gly Glu 
    290                 295                 300                 


Leu Phe Gln Ala Leu Cys Lys Leu Tyr Ser Ala Tyr Ile Leu Gln Glu 
305                 310                 315                 320 


Leu Leu Ser Tyr Ala Asp Pro Ser Gly Gln Thr Ile Ser Ala Asn Met 
                325                 330                 335     


Val Ala Lys Tyr Lys Gln Tyr Gly Arg Asp Leu Arg Leu Leu Lys Glu 
            340                 345                 350         


Leu Thr Arg Thr Tyr Ala Pro Gln Lys Tyr Asp Leu Phe Phe Arg Gly 
        355                 360                 365             


Glu Thr Tyr Ala Gly Ser Ser Asp Tyr Val Val Asp Glu Ala Arg Gly 
    370                 375                 380                 


Tyr Thr Arg Tyr Asn Leu Gly Thr Thr Lys Ala Asn Tyr Asp Asp Phe 
385                 390                 395                 400 


Gln Lys Ser Val Lys Glu Leu Phe Lys Gly Thr Asp Ala Leu Gln Asp 
                405                 410                 415     


Glu Arg Tyr Gln Glu Met Met Val Ala Phe Gly Glu Gln Lys Phe Leu 
            420                 425                 430         


Arg Arg Leu Lys Thr Ser Asp Asn Gly Ser Ile Tyr Tyr Gln Leu His 
        435                 440                 445             


Leu Glu Glu Leu His Thr Ile Leu Glu Asn Gln Gly Lys His Tyr Pro 
    450                 455                 460                 


Phe Leu Leu Ser Glu Glu Asp Lys Ile Glu Ser Leu Val Ser Phe Arg 
465                 470                 475                 480 


Ile Pro Tyr Tyr Val Gly Pro Leu Thr Arg Lys Asn Ala Ala Ile Gly 
                485                 490                 495     


His Asp Gly Lys Glu Arg Phe Ala Trp Ser Ser Arg Lys Asp Gly Met 
            500                 505                 510         


Glu His Ala Val Ile Thr Pro Trp Asn Trp Glu Glu Ile Ile Asp Arg 
        515                 520                 525             


Asp Lys Ser Ala Glu Asp Phe Ile Met Arg Met Thr Gly Asp Cys Thr 
    530                 535                 540                 


Tyr Leu Gln Gly Glu Pro Val Leu Pro Lys Cys Ser Leu Leu Tyr Glu 
545                 550                 555                 560 


Glu Phe Cys Ala Leu Asn Glu Phe Asn Gly Ala His Trp Thr Val Asp 
                565                 570                 575     


Gly Asp Asp Glu Arg Arg Phe Asp Ala Ala Gln Arg Glu Arg Ile Met 
            580                 585                 590         


Cys Asp Leu Phe Arg Arg Thr Arg Ser Val Thr Tyr Asn Lys Val Ser 
        595                 600                 605             


Asp Trp Leu Glu Arg Lys Tyr Asn Phe Thr Gly Ala Arg Val Arg Gly 
    610                 615                 620                 


Gly Gln Gly Glu His Gly Phe Glu Ser Lys Leu Gly Ser Tyr Ile Phe 
625                 630                 635                 640 


Phe Cys Lys Asp Val Phe Lys Thr Asp Gly Leu Asp Glu Ala Asp Tyr 
                645                 650                 655     


Thr Met Ile Glu Gln Ile Ile Leu Trp Ser Thr Leu Phe Glu Asp Arg 
            660                 665                 670         


Asp Ile Leu Lys Arg Lys Ile Glu Glu Ala Tyr Gly Gly Asp Arg Leu 
        675                 680                 685             


Thr Ser Glu Gln Ile Lys Val Ile Cys Lys Lys Arg Phe Thr Gly Trp 
    690                 695                 700                 


Gly Arg Leu Ser Lys Arg Leu Leu Thr Asp Ile Lys Val Asn Thr Asp 
705                 710                 715                 720 


Thr Gly Arg Lys Ser Ile Met Asp Val Leu Arg Glu Gly Asn Pro Asn 
                725                 730                 735     


Asn Gly Gln Arg Ser Arg Thr Met Val Phe Met Glu Val Leu Arg Asp 
            740                 745                 750         


Glu Asp Leu Gly Phe Gln Lys Ala Ile Asp Gly Leu Asn Arg Asp Tyr 
        755                 760                 765             


Phe Arg Glu His Asn Asn Gly Leu Met Asp Val Asn Asp Leu Pro Gly 
    770                 775                 780                 


Ser Pro Ala Ile Arg Arg Ser Ile Asn Gln Ala Val Arg Ile Val Asp 
785                 790                 795                 800 


Glu Ile Ala Ser Ile Ala Arg Lys Glu Pro Thr Asn Ile Phe Ile Glu 
                805                 810                 815     


Val Thr Arg Glu Glu Asp Asp Pro Arg Lys Lys Gly Lys Arg Thr Lys 
            820                 825                 830         


Arg Arg Tyr Asp Ala Ile Lys Ser Ala Leu Glu Lys Phe Lys Lys Asp 
        835                 840                 845             


Asp Pro Ser Leu Trp Lys Glu Leu Cys Glu Lys Ala Pro Gly Asp Met 
    850                 855                 860                 


Asp Glu Arg Leu Ser Leu Tyr Phe Met Gln Arg Gly Lys Cys Met Tyr 
865                 870                 875                 880 


Ser Gly Arg Pro Ile Lys Ile Glu Glu Leu His Thr Gly Lys Tyr Glu 
                885                 890                 895     


Val Asp His Ile Ile Pro Arg Ser Tyr Ile Lys Asp Asp Ser Phe Glu 
            900                 905                 910         


Asn Lys Val Leu Val Tyr Arg Glu Glu Asn Gln His Lys Thr Asp Ala 
        915                 920                 925             


Leu Leu Ile Asp Ser Ser Ile Arg Gln Lys Met Gly Gly Tyr Trp Arg 
    930                 935                 940                 


Met Leu His Asp Ala Lys Leu Val Gly Asp Lys Lys Phe Arg Asn Leu 
945                 950                 955                 960 


Phe Arg Asn His Ile Asp Asp Lys Ala Met Lys Gly Phe Val Ala Arg 
                965                 970                 975     


Gln Ile Val Glu Thr Ser Gln Met Val Lys Leu Val Gln Thr Leu Phe 
            980                 985                 990         


Glu Ala Arg Tyr Pro Asn Thr Arg  Ile Val Pro Val Lys  Ala Gly Ile 
        995                 1000                 1005             


Ser His  Asp Leu Arg Glu Ala  Ala Gly Leu Val Lys  Cys Arg Glu 
    1010                 1015                 1020             


Ala Asn  Asp Phe His His Ala  His Asp Ala Phe Leu  Ala Cys Arg 
    1025                 1030                 1035             


Ile Gly  Leu Phe Ile Gln Lys  Arg His Pro Ser Val  Tyr Asp Asn 
    1040                 1045                 1050             


Pro Ile  Gly Leu Ala Arg Ile  Met Arg Asp Tyr Ala  Arg Met Gln 
    1055                 1060                 1065             


Ala Arg  Glu Tyr Lys Lys Ser  His Cys Leu Ala His  Thr Gln Gly 
    1070                 1075                 1080             


Phe Ile  Val Asn Ser Phe Leu  Ser Ser Gly Phe Asp  Glu Glu Thr 
    1085                 1090                 1095             


Gly Glu  Ile Phe Lys Asp Asp  Trp Asp Ala Lys Ala  Glu Val Glu 
    1100                 1105                 1110             


Gly Ile  Arg Arg Val Leu Asn  Cys Arg Gln Cys Phe  Ile Ser Arg 
    1115                 1120                 1125             


Met Pro  Val Glu Gly Asp Thr  Arg Tyr Gly Gly Arg  Tyr Trp Gly 
    1130                 1135                 1140             


Glu Thr  Ile Tyr Ser Pro Lys  Gly Lys His Lys His  Glu Ile Pro 
    1145                 1150                 1155             


Leu Lys  Gln Gly Leu Asp Pro  Asn Leu Tyr Gly Gly  Tyr Ser Asp 
    1160                 1165                 1170             


Leu Leu  Tyr Ser Tyr Phe Leu  Ile Tyr Glu Ala Ser  Asp Val Ser 
    1175                 1180                 1185             


Ser Gly  Glu Arg Val Leu Arg  Phe Ile Gly Ile Pro  Thr Ser Ile 
    1190                 1195                 1200             


Ala Ala  Arg Met Ala Asn Gln  Lys Arg Leu Glu Glu  Tyr Val Ser 
    1205                 1210                 1215             


Arg Leu  Ala Leu Gln Glu Asn  Leu Glu His Val Arg  Met Val Arg 
    1220                 1225                 1230             


Lys Ile  Met Lys Lys Gln Leu  Ile Glu Val Asp Asn  Cys Arg Leu 
    1235                 1240                 1245             


Leu Val  Thr Ala Ala Asp Ala  Val Thr Asn Ala Thr  Glu Leu Ala 
    1250                 1255                 1260             


Phe Ser  Leu Asp Glu Met Lys  Ile Ile Ser Thr Cys  Ala Lys Cys 
    1265                 1270                 1275             


Ile Asn  Gly Ala Asp Pro Ser  Ala Ile Asp Lys Ile  Gly Asn Ala 
    1280                 1285                 1290             


Gln Asp  Ser Phe Phe Asp Asn  Leu Lys Arg Arg Gly  Ser Asp Arg 
    1295                 1300                 1305             


Cys Ala  Leu Leu Phe Ser Gln  Leu Lys Leu Asp Lys  Leu Ser Gln 
    1310                 1315                 1320             


Asn Phe  Tyr Met Ile Ser Ser  Asp Asp Lys Ser Lys  Ile Leu Ile 
    1325                 1330                 1335             


Ser Ile  Leu Asp Arg Ile Arg  Ala Lys Ser Asn Ser  Val Asp Leu 
    1340                 1345                 1350             


Ser Leu  Val Gly Gly Ala Lys  His Ala Ala Gln Met  Lys Phe Asp 
    1355                 1360                 1365             


Phe Asn  Ala Lys Leu Asn Asn  Pro Ala Ser Ser Phe  Val Leu Ile 
    1370                 1375                 1380             


Asp Gln  Ser Val Thr Gly Met  Phe Glu Arg Arg Thr  Arg Ile Gly 
    1385                 1390                 1395             


Leu 
    


<210> 373
<211> 1535
<212> PRT
<213> Ornithobacterium rhinotracheale

<400> 373
Met Asn Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Ile Lys Val Leu Asn Asp Lys Thr Arg Leu Pro Leu Glu Ile 
            20                  25                  30          


Ile Asp Leu Gly Val Val Val Ile Pro Thr Asp Gln Arg Thr Leu Asp 
        35                  40                  45              


Lys Phe Ser Lys Gly Glu Ser Ile Ser Lys Thr Ala Glu Arg Thr Lys 
    50                  55                  60                  


Gln Lys Gly Val Arg Lys Leu Tyr Glu Arg Lys Lys Leu Arg Arg Glu 
65                  70                  75                  80  


Arg Leu His Arg Val Leu Asn Ile Leu Gly Phe Leu Pro Glu His Tyr 
                85                  90                  95      


Ser Lys Lys Ile Asp Phe Lys Lys His Leu Gly Gln Phe Phe Gly Asn 
            100                 105                 110         


Ser Gln Pro Lys Ile Ser Tyr Val Glu Asn Asp His Gly Lys His Glu 
        115                 120                 125             


Phe Ile Phe Met Asp Ser Tyr Arg Glu Met Leu Lys Glu Phe Ser Lys 
    130                 135                 140                 


His Asn Ile Lys Asn Val Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg 
145                 150                 155                 160 


Lys Lys Ala Leu Ser Gln Lys Ile Ser Lys Glu Glu Leu Ala Trp Val 
                165                 170                 175     


Ile Leu Asn Phe Asn Lys Lys Arg Gly Tyr Tyr Gln Phe Arg Asp Asp 
            180                 185                 190         


Asn Ala Asp Glu Asn Lys Glu Asn Lys Ile Glu Lys Tyr Tyr Ala Leu 
        195                 200                 205             


Lys Val Thr Asn Val Lys Lys Glu Asp Ala Gln Asn Tyr Thr Ile Thr 
    210                 215                 220                 


Leu Glu Asn Gly Trp Ile Tyr Lys Asn Lys Ser Lys Ile Ser Leu Leu 
225                 230                 235                 240 


Asp Trp Val Gly Ser Thr Lys Glu Phe Ile Ser Thr Glu Lys Phe Asp 
                245                 250                 255     


Asn Lys Gly Asn Ile Ile Lys Lys Lys Asn Gly Glu Asp Asp Arg Thr 
            260                 265                 270         


Leu Lys Leu Val Asp Ser Glu Lys Asp Trp Ile Ala Ile Lys Lys Ser 
        275                 280                 285             


Thr Glu Asp Arg Ile Glu Asn Tyr Gly Lys Thr Val Gly Thr Tyr Leu 
    290                 295                 300                 


Tyr Glu His Leu Leu Lys Asp Pro Asn Gln Lys Leu Asn Gly Glu Leu 
305                 310                 315                 320 


Ile Asn Ile Ile Asp Arg Lys Phe Tyr Lys Asn Glu Leu Lys Gln Ile 
                325                 330                 335     


Leu Glu Lys Gln Lys Glu Phe His Pro Glu Leu Leu Asn Glu Asp Leu 
            340                 345                 350         


Phe Gln Lys Ser Ile Ile Glu Leu Tyr Pro Lys Asn Ser Thr Arg Gln 
        355                 360                 365             


Lys Glu Leu Lys Asn Lys Asp Leu Cys Tyr Leu Leu Ile Asp Asp Val 
    370                 375                 380                 


Ile Tyr Tyr Gln Arg Asp Leu Lys Lys Lys Asn Ser Thr Ile Asn Lys 
385                 390                 395                 400 


Cys Ser Phe Glu Ser Arg Glu Tyr Tyr Leu Asn Gly Glu Lys Gln Ile 
                405                 410                 415     


Gln Lys Ile Asn Cys Ile Ala Lys Ser Lys Pro Leu Tyr Gln Glu Phe 
            420                 425                 430         


Arg Thr Leu Gln Phe Ile Lys Asn Leu Lys Val Tyr Glu Ile Ile Asp 
        435                 440                 445             


Gly Leu Glu Lys Asp Ile Thr Ser Lys Leu Leu Pro Asp Phe Glu Thr 
    450                 455                 460                 


Lys Glu His Phe Phe Glu Trp Leu Asn Asp Lys Glu Lys Ile Asp Gln 
465                 470                 475                 480 


Leu Gln Leu Leu Ser Tyr Lys Cys Phe Asp Leu His Asp Asn Val Lys 
                485                 490                 495     


Asn Asp Leu Ile Ala Lys Gly Ile Lys Arg Pro Thr Glu Lys Ala Ile 
            500                 505                 510         


Arg Thr Glu Leu Leu Glu Lys Tyr Arg Trp Asn Tyr Ser Lys Asp Asn 
        515                 520                 525             


Asp Arg Asn Phe Leu Leu Asn Glu Thr Arg Phe Lys Ile Leu Lys Tyr 
    530                 535                 540                 


Leu Lys Lys Val Asp Lys Lys Leu Thr Leu Thr Asn Glu Gln Ile Glu 
545                 550                 555                 560 


Ser Leu Trp Leu Leu Leu Tyr Ser Ala Lys Asp Glu Arg Glu Leu Lys 
                565                 570                 575     


Asn Gly Leu Gln Lys Phe Ser Glu Lys Asn Lys Leu Pro Lys Lys Phe 
            580                 585                 590         


Ser Asp Ile Phe Ile Ser Phe Pro Pro Phe Lys Lys Glu Tyr Gly Ala 
        595                 600                 605             


Tyr Ser Glu Lys Ala Leu Lys Lys Leu Leu Ser Leu Val Arg Phe Gly 
    610                 615                 620                 


Lys Tyr Trp Ser Phe Asn Lys Ile Asp Asn Asn Ile Gln Asn Lys Ile 
625                 630                 635                 640 


Met Asn Ile Leu Asn Gly Glu Val Asp Asp Ser Ile Ser Asp Arg Val 
                645                 650                 655     


Arg Glu Lys Thr Ile Leu Leu Gln Asp Lys Asn Asp Phe Gln Asp Leu 
            660                 665                 670         


Pro Leu Trp Leu Ala Ser Tyr Val Ala Tyr Asn Arg Phe Ser Glu Val 
        675                 680                 685             


Ser Glu Ile Lys Tyr Trp Asp Ser Pro Asp Lys Ile Glu Phe Leu Lys 
    690                 695                 700                 


Gln His Ser Ile Gly Asn Pro Ile Val Glu Lys Ile Ile Asn Glu Thr 
705                 710                 715                 720 


Leu Lys Leu Ile Lys Asp Ile Trp Val Ile His Gly Lys Ser Cys Lys 
                725                 730                 735     


Asn Phe Phe Ser Glu Ile His Ile Glu Leu Ser Arg Glu Ile Lys Ser 
            740                 745                 750         


Ser Ser Lys Lys Arg Ala Gln Ile Thr Asn Asn Asn Thr Lys Asn Gln 
        755                 760                 765             


Lys Leu Asn Asn Leu Ile Lys Ser Leu Leu Ile Glu Met Ala Ser Asp 
    770                 775                 780                 


Thr Lys Tyr Glu Asn Val Thr Pro Tyr Ser Pro Ser Gln Gln Glu Ile 
785                 790                 795                 800 


Leu Lys Ile Tyr Asp Glu Gly Ile Tyr Ser Lys Glu Glu Asn Ser Glu 
                805                 810                 815     


Lys Ile Lys Glu Ile Asn Lys Ile Arg Asn Asn Asn Lys Ile Ser Lys 
            820                 825                 830         


Ser Asp Ile Thr Lys Tyr Lys Leu Trp Leu Glu Gln Gly Tyr Ile Ser 
        835                 840                 845             


Pro Tyr Thr Gly Lys Ile Ile Pro Leu Thr Lys Leu Phe Thr Ala Lys 
    850                 855                 860                 


Tyr Gln Lys Glu His Ile Ile Pro Gln Thr Lys Phe Phe Asp Asp Ser 
865                 870                 875                 880 


Phe Asn Asn Lys Val Ile Cys Glu Ala Glu Val Asn Lys Leu Lys Asp 
                885                 890                 895     


Asn Ser Leu Ala Met Asn Phe Ile Lys Ala Lys Gly Gly Lys Ala Val 
            900                 905                 910         


Lys Leu Ser Asp Gly Glu Thr Val Thr Ile Leu Asn Gln Glu Glu Tyr 
        915                 920                 925             


Lys Gln Leu Val Arg Thr Ser Phe Lys Lys Asn Ser Ile Lys Leu Arg 
    930                 935                 940                 


Asn Leu Leu Leu Glu Glu Ile Pro Asp Thr Phe Thr Lys Arg Gln Leu 
945                 950                 955                 960 


Asn Asp Thr Lys Tyr Ile Ser Lys Leu Val Leu Ser Leu Leu Ser Asn 
                965                 970                 975     


Ile Val Arg Glu Lys Gly Glu Leu Glu Ser Thr Ala Lys Arg Ile Val 
            980                 985                 990         


Ser Thr Asn Gly Gln Ile Thr Ser  Ile Leu Arg Asn Asp  Trp Gly Leu 
        995                 1000                 1005             


Asn Asn  Ile Trp Asn Lys Leu  Ile Thr Pro Arg Phe  Glu Arg Leu 
    1010                 1015                 1020             


Asn Asn  Ile Asn Lys Asn Lys  Ile Tyr Gly Asn Trp  Glu Asn Lys 
    1025                 1030                 1035             


Lys Gly  Lys Asn Val Phe Gln  Ile Asn Tyr Leu Asn  Asp Asn Leu 
    1040                 1045                 1050             


Ser Thr  Leu Asn Thr Lys Arg  Ile Asp His Arg His  His Ala Leu 
    1055                 1060                 1065             


Asp Ala  Leu Ile Val Ala Cys  Thr Thr Arg Asn His  Ile Asn Phe 
    1070                 1075                 1080             


Leu Asn  Asn Gln Tyr Ala Lys  Ser Arg Asn Gln Arg  His Asp Leu 
    1085                 1090                 1095             


Arg Ala  Lys Leu Lys Arg Arg  Glu Thr Ile Thr Thr  Glu Gly Ser 
    1100                 1105                 1110             


Lys Lys  Gln Val Phe Lys Asp  Phe Ile Lys Pro Trp  Glu Ser Phe 
    1115                 1120                 1125             


Thr Gln  Asp Ala Leu Lys Lys  Leu Glu Thr Thr Ile  Val Asn Phe 
    1130                 1135                 1140             


Lys Val  Asn Lys Arg Ile Ile  Asn Lys Thr Ile Asn  Trp Tyr Lys 
    1145                 1150                 1155             


Lys Trp  Glu Lys Gln Lys Asp  Gly Thr Tyr Lys Lys  Ile Gln Lys 
    1160                 1165                 1170             


Lys Gln  Thr Lys Gly Asp Ala  Trp Ala Ile Arg Lys  Pro Leu His 
    1175                 1180                 1185             


Ile Asp  Thr Ile Tyr Gly Ile  Val Cys Lys Lys Leu  Pro Leu Lys 
    1190                 1195                 1200             


Ser Ala  Leu Glu Asn Tyr Lys  Asn Ile Ile Asp Glu  Asn Leu Lys 
    1205                 1210                 1215             


His Lys  Ile Lys Glu Leu Lys  Glu Val Asn Lys Phe  Asp Asn Asn 
    1220                 1225                 1230             


Gln Ile  Ile Asn Phe Phe Lys  Glu Cys Asn Phe Ile  Phe Glu Asp 
    1235                 1240                 1245             


Asn Asn  Ile Gln Lys Val Glu  Val Tyr Asp Phe Lys  Asp Asn Arg 
    1250                 1255                 1260             


Asp Lys  Thr Ile Leu Ser Ser  Ser Arg Gln Leu Ile  Asp Glu Ser 
    1265                 1270                 1275             


Phe Thr  Pro Lys Lys Ile Gly  Lys Val Leu Asp Pro  Thr Ile Arg 
    1280                 1285                 1290             


Asn Ile  Leu Leu Lys His Leu  Asn Ser Thr Lys Tyr  Asn Asn Lys 
    1295                 1300                 1305             


Phe Asp  Ser Asp Gly Asn Pro  Ile Lys Pro Glu Lys  Leu Ala Phe 
    1310                 1315                 1320             


Ser Pro  Glu Gly Leu Lys Asp  Leu Asn Lys Asn Ile  Lys His Leu 
    1325                 1330                 1335             


Asn Asn  Asn Lys Glu His Gln  Pro Ile Lys Arg Val  Lys Leu Phe 
    1340                 1345                 1350             


Glu Thr  Leu Gly Asn Lys Ile  Lys Val Gly Tyr Thr  Gln Gln Lys 
    1355                 1360                 1365             


Asn Lys  Lys Phe Ala Glu Thr  Ala Thr Gly Thr Asn  Leu Phe Leu 
    1370                 1375                 1380             


Gly Ile  Tyr Ser Asp Asn Asn  Lys Arg Asp Phe Lys  Thr Ile Pro 
    1385                 1390                 1395             


Leu Ile  Leu Ala Ile Gln Arg  Glu Lys Glu Gly Leu  Asn Pro Cys 
    1400                 1405                 1410             


Pro Asp  Thr Asp Glu Lys Gly  Asn Gln Leu Leu Phe  Ser Leu Ser 
    1415                 1420                 1425             


Pro Asn  Glu Leu Val Phe Val  Pro Asn Asn Glu Glu  Arg Lys Asn 
    1430                 1435                 1440             


Pro Asn  Leu Val Asp Phe Glu  Asn Leu Ser Lys Asp  Gln Ile Asp 
    1445                 1450                 1455             


Arg Ile  Tyr Lys Phe Val Ser  Cys Thr Gly Ser Glu  Ala Tyr Phe 
    1460                 1465                 1470             


Val Pro  Ser Arg Thr Ala Lys  Pro Ile Ile Glu Asn  Glu Asn Gly 
    1475                 1480                 1485             


Thr Asn  Asn Lys Ser Gln Arg  Ile Ile Glu Phe Asn  Glu Lys Thr 
    1490                 1495                 1500             


Ser Ile  Lys Asn Glu Lys Asn  Glu Pro Val Leu Ile  Lys Thr Ile 
    1505                 1510                 1515             


Cys Trp  Lys Ile Glu Val Asn  Arg Leu Gly Lys Ile  Ile Lys Val 
    1520                 1525                 1530             


Ile Lys  
    1535 


<210> 374
<211> 1443
<212> PRT
<213> Parabacteroides johnsonii


<220>
<223> Parabacteroides johnsonii DSM 18315

<400> 374
Met Ile Lys Leu Leu Tyr Leu Glu Lys Leu Lys Gln Tyr Thr Met Lys 
1               5                   10                  15      


Lys Ile Leu Gly Leu Asp Leu Gly Thr Ser Ser Ile Gly Trp Ala Leu 
            20                  25                  30          


Val Asn Glu Ala Glu Asn Ser Asp Glu Val Ser Ser Ile Ile Lys Leu 
        35                  40                  45              


Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Met Gln Asn Phe Glu 
    50                  55                  60                  


Lys Gly Lys Ser Ile Thr Thr Asn Ala Asp Arg Thr Leu Lys Arg Ser 
65                  70                  75                  80  


Met Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Asp Ala Leu Ile 
                85                  90                  95      


Glu Leu Leu Lys Lys Val Gly Phe Ile Thr Asp Lys Thr Ile Leu Ser 
            100                 105                 110         


Glu Gln Gly Asn Arg Thr Thr Phe Glu Thr Tyr Arg Leu Arg Ala Lys 
        115                 120                 125             


Ala Ala Glu Glu Glu Ile Ser Leu Lys Glu Leu Ala Arg Val Leu Leu 
    130                 135                 140                 


Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala Lys Gly 
145                 150                 155                 160 


Glu Glu Glu Gly Ala Leu Ile Asp Gly Met Glu Ile Ala Lys Lys Leu 
                165                 170                 175     


Tyr Asp Glu Asp Leu Thr Pro Gly Gln Leu Cys Leu Gln Leu Leu Glu 
            180                 185                 190         


Ser Gly Lys Lys Phe Phe Pro Asp Phe Tyr Arg Ser Asp Leu Gln Glu 
        195                 200                 205             


Glu Phe Asn Lys Ile Trp Asp Phe Gln Lys Gln Phe Asn Leu Phe Ser 
    210                 215                 220                 


Phe Cys Asp Val Ala Lys Glu Glu Val Lys Gly Lys Asn Lys Ser Gln 
225                 230                 235                 240 


Thr Trp Ala Ile Leu Ala Lys Tyr Phe Val Glu Thr Lys Lys Val Asn 
                245                 250                 255     


Val Trp Asn Glu His Glu Ala Gln Thr Glu Asn Arg Glu Glu Val Tyr 
            260                 265                 270         


Lys Leu Val Gly Leu Lys Arg Thr Val Lys Gly Glu Glu Leu Lys Lys 
        275                 280                 285             


Glu Asn Tyr Arg Trp Arg Val Gln Ala Leu Thr Glu Gln Leu Asp Leu 
    290                 295                 300                 


Glu Lys Ile Ala Val Val Leu Gln Glu Ile Asn Gly Gln Ile Ser Ala 
305                 310                 315                 320 


Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Val Leu Tyr 
                325                 330                 335     


Phe Asn Arg Gln Thr Val Gly Gln Tyr Gln Met Ala Glu Leu Asn Lys 
            340                 345                 350         


Asn Pro Asn Met Ser Leu Arg Asn Met Val Phe Tyr Arg Gln Asp Tyr 
        355                 360                 365             


Leu Asp Glu Phe Asn Val Ile Trp Glu Lys Gln Ala Glu Phe His Lys 
    370                 375                 380                 


Glu Leu Thr Pro Glu Leu Lys Lys Glu Ile Arg Asp Ile Ile Ile Phe 
385                 390                 395                 400 


Tyr Gln Arg Arg Leu Lys Ser Gln Lys Gly Leu Ile Ser Phe Cys Glu 
                405                 410                 415     


Phe Glu Asn Arg Glu Val Val Val Glu Lys Glu Gly Lys Lys Gln Thr 
            420                 425                 430         


Lys Ile Ile Gly Cys Lys Val Ile Pro Arg Ser His Pro Leu Phe Gln 
        435                 440                 445             


Glu Phe Lys Ile Trp Gln Thr Leu Asn Asn Ile Glu Val Phe Val Gly 
    450                 455                 460                 


Glu Lys Lys Gly Lys Arg Lys Lys Ser Asn Val Ser Ser Asp Leu Phe 
465                 470                 475                 480 


Gly Asp Thr Glu Asp Ala Leu Ile Thr Glu Gly Arg Arg Phe Leu Tyr 
                485                 490                 495     


Gln Glu Glu Lys Lys Ile Leu Ala Lys Glu Leu Ser Ile Lys Lys Gly 
            500                 505                 510         


Leu Thr Lys Ala Glu Ile Leu Arg Leu Leu Phe Glu Asn Pro Gln Glu 
        515                 520                 525             


Leu Asp Ile Asn Phe Lys Gln Ile Asp Gly Asn Gln Thr Gly Phe Ala 
    530                 535                 540                 


Leu Phe Ser Ala Tyr Ser Asn Met Ile Glu Lys Tyr Gly Tyr Glu Pro 
545                 550                 555                 560 


Leu Asp Phe Lys Lys Pro Ala Glu Asp Leu Ile Ser Gln Leu Lys Thr 
                565                 570                 575     


Val Phe Thr Asp Leu Gly Trp Asn Thr Asp Leu Leu Phe Ile Asp Leu 
            580                 585                 590         


Asp Lys Glu Asn Lys Glu Trp Glu Lys Gln Pro Tyr Phe Arg Leu Trp 
        595                 600                 605             


His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Pro Thr Gly Asn Gly 
    610                 615                 620                 


Lys Leu Ile Glu Lys Ile Met Gln Leu Cys Gly Ile Glu Lys Glu Tyr 
625                 630                 635                 640 


Ala Ile Glu Leu Ala Asn Val Ser Leu Gln Asp Asp Tyr Gly Ser Leu 
                645                 650                 655     


Ser Ala Lys Ala Ile Lys Lys Ile Leu Leu Tyr Leu Lys Glu Gly Asn 
            660                 665                 670         


Gln Tyr Asp Met Ala Cys Glu Tyr Ala Gly Tyr Arg His Ser Lys Ser 
        675                 680                 685             


Ser Leu Thr Lys Glu Glu Ile Glu Asn Lys Val Leu Lys Asp Lys Leu 
    690                 695                 700                 


Glu Ile Leu Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile 
705                 710                 715                 720 


Leu Asn Gln Met Val Asn Val Ile Asn Thr Val Met Glu Val Tyr Gly 
                725                 730                 735     


Arg Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys Lys Ser 
            740                 745                 750         


Ala Lys Glu Arg Glu Glu Leu Thr Lys Ala Val Ala Lys Asn Thr Arg 
        755                 760                 765             


Glu His Glu Glu Ile Arg Lys Val Leu Gln Ser Glu Phe Gly Met Ile 
    770                 775                 780                 


Asn Val Ser Arg Asn Asp Ile Ile Arg Tyr Lys Leu Tyr Glu Glu Leu 
785                 790                 795                 800 


Lys Asp Asn Gly Tyr Lys Thr Leu Tyr Ser Asn Gln Tyr Ile Pro Arg 
                805                 810                 815     


Glu Lys Leu Phe Ser Lys Glu Ile Asp Ile Glu His Ile Ile Pro Gln 
            820                 825                 830         


Ser Arg Leu Phe Asp Asp Ser Leu Ser Asn Lys Thr Leu Glu Tyr Lys 
        835                 840                 845             


Ser Ile Asn Ile Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe Val Lys 
    850                 855                 860                 


Glu Lys Tyr Gly Glu Glu Gly Leu Gln Gln Tyr Leu Asn Arg Cys Glu 
865                 870                 875                 880 


Asn Leu Cys Lys Asp Lys Lys Ala Lys Leu Arg Lys Leu Lys Met Glu 
                885                 890                 895     


Leu Asn Glu Ile Pro Asp Gly Phe Ile Asp Arg Asp Leu Arg Asn Thr 
            900                 905                 910         


Gln Tyr Ile Ala Lys Lys Ala Leu Ser Met Leu Thr Glu Ile Cys Arg 
        915                 920                 925             


Arg Val Val Ala Thr Thr Gly Ser Ile Thr Asp Lys Leu Arg Glu Asp 
    930                 935                 940                 


Trp Gln Leu Val Asp Val Met Lys Glu Leu Asn Leu Pro Lys Tyr Glu 
945                 950                 955                 960 


Ala Leu Gly Leu Val Glu Val Tyr Glu Asp Lys Asp Gly Arg Lys Ile 
                965                 970                 975     


Lys Arg Ile Lys Asp Trp Thr Lys Arg Asn Asp His Arg His His Ala 
            980                 985                 990         


Met Asp Ala Leu Thr Val Ala Phe  Thr Lys Asp Val Phe  Ile Gln Tyr 
        995                 1000                 1005             


Phe Asn  Asn Lys Asn Ala Ala  Trp Glu Ser Asp Ser  Lys Glu His 
    1010                 1015                 1020             


Thr Asn  Ile Val Gly Ile Lys  Thr Arg Tyr Phe Glu  Ser Gly Lys 
    1025                 1030                 1035             


Ala Val  Pro Pro Ile Pro Leu  Gly Gln Phe Arg Val  Glu Ala Lys 
    1040                 1045                 1050             


Cys His  Leu Glu Asn Leu Leu  Val Ser Ile Lys Ala  Lys Asn Lys 
    1055                 1060                 1065             


Val Val  Thr Thr Asn Val Asn  Cys Ile Lys Lys Lys  Gly Gly Thr 
    1070                 1075                 1080             


Tyr Lys  Asn Thr Gln Gln Thr  Pro Arg Gly Gln Leu  His Leu Glu 
    1085                 1090                 1095             


Thr Ile  Tyr Gly Ser His Asn  Gln Tyr Val Thr Lys  Ile Glu Lys 
    1100                 1105                 1110             


Val Asn  Ala Ser Phe Asp Ala  Val Lys Ile Ala Thr  Val Ser Lys 
    1115                 1120                 1125             


Gln Asp  Tyr Arg Asn Ala Leu  Leu Lys Arg Leu Glu  Val Phe Gly 
    1130                 1135                 1140             


Asn Asp  Pro Lys Lys Ala Phe  Thr Gly Lys Asn Ser  Leu Glu Lys 
    1145                 1150                 1155             


Asn Pro  Ile Tyr Leu Asp Arg  Ala Gln Thr Ile Gln  Val Pro Asp 
    1160                 1165                 1170             


Lys Val  Gln Thr Val Glu Leu  Glu Thr Ala Tyr Thr  Ile Arg Lys 
    1175                 1180                 1185             


Pro Val  Asp Pro Thr Leu Asn  Val Asp Lys Val Val  Asp Lys Lys 
    1190                 1195                 1200             


Ile Arg  Leu Ile Leu Glu Gln  Arg Leu Lys Glu Tyr  Gly Gly Asp 
    1205                 1210                 1215             


Ala Lys  Lys Ala Phe Val Asn  Leu Asp Glu Asn Pro  Ile Trp Leu 
    1220                 1225                 1230             


Asn Glu  Glu Lys Gly Ile Ser  Ile Lys Arg Val Thr  Ile Arg Gly 
    1235                 1240                 1245             


Ile Ser  Lys Ala Gln Ala Leu  His Asp Lys Lys Asp  Lys Asp Gly 
    1250                 1255                 1260             


Asn Phe  Ile Leu Asp Glu Thr  Gly Lys Arg Ile Pro  Val Asp Phe 
    1265                 1270                 1275             


Val Asn  Thr Gly Asn Asn His  His Val Ala Ile Tyr  Arg Lys Pro 
    1280                 1285                 1290             


Val Leu  Asp Lys Lys Gly Gln  Val Ile Phe Asp Asp  Glu Gly Asn 
    1295                 1300                 1305             


Pro Met  Tyr Glu Leu Asp Glu  Asp Val Val Pro Phe  Phe Glu Ala 
    1310                 1315                 1320             


Val Thr  Arg Ala Asn Leu Gly  Ile Pro Ile Ile Asp  Lys Asp Tyr 
    1325                 1330                 1335             


Lys Lys  Ser Glu Gly Trp Gln  Phe Leu Phe Ser Met  Lys Gln Asn 
    1340                 1345                 1350             


Glu Tyr  Phe Val Phe Pro Asn  Glu Lys Thr Gly Phe  Asn Pro Lys 
    1355                 1360                 1365             


Glu Val  Asp Leu Leu Asp Pro  Asp Asn Tyr Ala Met  Ile Ser Pro 
    1370                 1375                 1380             


Asn Leu  Phe Arg Val Gln Lys  Ile Gly Leu Asn Asp  Tyr Thr Phe 
    1385                 1390                 1395             


Arg His  His Leu Glu Thr Thr  Ile Gln Asn Asp Leu  Lys Phe Ile 
    1400                 1405                 1410             


Thr Trp  Ile Arg Cys Gly Lys  Ser Gly Ile Lys Asp  Ile Val Lys 
    1415                 1420                 1425             


Val Arg  Ile Asn His Ile Gly  Gln Ile Val Ser Val  Gly Glu Tyr 
    1430                 1435                 1440             


<210> 375
<211> 1424
<212> PRT
<213> Parabacteroides sp.


<220>
<223> Parabacteroides sp. D13

<400> 375
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Glu Thr Asp Glu Glu Val Ser Ser Ile Ile 
            20                  25                  30          


Arg Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Thr Gln Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Glu Arg Thr Leu Lys 
    50                  55                  60                  


Arg Ser Met Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Asp Ala 
65                  70                  75                  80  


Leu Val Glu Phe Leu Lys Glu Leu Gly Phe Ile Thr Asp Glu Thr Ile 
                85                  90                  95      


Leu Ser Glu Gln Gly Asn Arg Thr Thr Phe Glu Thr Cys Arg Leu Arg 
            100                 105                 110         


Ala Lys Ala Ala Glu Glu Glu Ile Ser Leu Glu Glu Leu Ser Arg Val 
        115                 120                 125             


Leu Leu Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Val 
    130                 135                 140                 


Lys Lys Glu Glu Asp Gly Val Leu Ile Asp Gly Met Glu Ile Ala Lys 
145                 150                 155                 160 


Lys Leu Tyr Glu Glu Asp Leu Thr Pro Gly Gln Leu Cys Ser Gln Leu 
                165                 170                 175     


Leu Glu Ser Gly Lys Lys Val Leu Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Glu Glu Leu Asp Arg Ile Trp Ser Val Gln Lys Gln Phe His Pro 
        195                 200                 205             


Asp Val Phe Cys Asp Ala Ala Lys Glu Glu Ile Lys Gly Lys Asn Arg 
    210                 215                 220                 


Ser Gln Thr Trp Ala Ile Leu Ala Asn Tyr Phe Val Trp Lys Glu Glu 
225                 230                 235                 240 


Val Val Gly Trp Asn Asp Arg Glu Ala Lys Asn Glu Thr Ile Glu Lys 
                245                 250                 255     


Glu Cys Lys Leu Val Gly Leu Lys Arg Thr Thr Lys Gly Tyr Glu Leu 
            260                 265                 270         


Lys Lys Glu Asn Tyr Arg Trp Arg Ala Gln Ala Leu Thr Glu Gln Leu 
        275                 280                 285             


Gly Leu Glu Glu Ile Ala Val Val Leu Gln Glu Ile Asn Gly Gln Ile 
    290                 295                 300                 


Asn Ala Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Val 
305                 310                 315                 320 


Leu Tyr Phe Asn His Gln Thr Val Gly Gln Tyr Gln Met Ala Glu Leu 
                325                 330                 335     


Asp Lys Asn Pro His Ala Ser Leu Arg Asn Met Val Phe Tyr Arg Gln 
            340                 345                 350         


Asp Tyr Leu Asp Glu Phe Asp Arg Ile Trp Glu Lys Gln Ala Glu Phe 
        355                 360                 365             


His Lys Glu Leu Thr Ala Glu Leu Lys Lys Glu Ile Arg Asp Met Ile 
    370                 375                 380                 


Ile Phe Tyr Gln Arg Arg Leu Lys Ser Gln Lys Gly Leu Ile Ser Phe 
385                 390                 395                 400 


Cys Glu Phe Glu Arg Leu Glu Ile Val Val Glu Lys Asp Gly Lys Lys 
                405                 410                 415     


Gln Thr Lys Val Ile Gly Cys Lys Val Ile Pro Arg Ser His Pro Leu 
            420                 425                 430         


Phe Gln Glu Phe Lys Val Trp Gln Thr Leu Asn Asp Ile Lys Val Leu 
        435                 440                 445             


Gly Arg Glu Lys Lys Arg Asn Ala Leu Ser Ala Ser Glu Ser Arg Ala 
    450                 455                 460                 


Leu Tyr Pro Glu Glu Lys Glu Ile Leu Ala Arg Glu Leu Ala Ile Lys 
465                 470                 475                 480 


Glu Asn Met Lys Lys Ala Asp Val Leu Lys Leu Leu Phe Glu Asn Pro 
                485                 490                 495     


Gln Glu Leu Asp Leu Asn Phe Lys Gln Ile Asp Gly Asn Arg Thr Gly 
            500                 505                 510         


Phe Ser Leu Phe Ser Ala Tyr Ser Lys Met Ile Glu Lys Tyr Gly Tyr 
        515                 520                 525             


Glu Pro Leu Asp Phe Lys Lys Pro Ala Asp Glu Ile Ile Gly Gln Leu 
    530                 535                 540                 


Arg Thr Ile Phe Thr Asp Leu Gly Trp Asn Thr Asn Leu Phe Thr Ile 
545                 550                 555                 560 


Asp Leu Thr Lys Glu Gly Lys Glu Leu Glu Met Gln Pro Tyr Phe Arg 
                565                 570                 575     


Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Ser Thr Gly 
            580                 585                 590         


Asn Gly Lys Leu Ile Glu Lys Ile Met Gln Leu Cys Gly Val Glu Lys 
        595                 600                 605             


Glu Tyr Ala Val Glu Leu Ala Ser Leu Ser Phe Gln Asp Asp Tyr Gly 
    610                 615                 620                 


Ser Leu Ser Ala Lys Ala Ile Lys Arg Ile Leu Pro Tyr Leu Lys Glu 
625                 630                 635                 640 


Gly Asn Leu Tyr Asp Val Ala Cys Glu Tyr Ala Gly Tyr Arg His Ser 
                645                 650                 655     


Lys Ser Ser Leu Thr Lys Glu Glu Ile Glu Asn Lys Val Leu Lys Gly 
            660                 665                 670         


Lys Leu Glu Val Leu Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu 
        675                 680                 685             


Lys Ile Leu Ser Gln Met Val Asn Val Ile Asn Thr Ile Ile Asp Thr 
    690                 695                 700                 


Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 
705                 710                 715                 720 


Lys Ser Ala Lys Glu Arg Glu Glu Leu Thr Lys Ala Ile Ala Lys Ser 
                725                 730                 735     


Thr Arg Glu His Glu Glu Ile Arg Lys Leu Leu Gln Asp Glu Phe Gly 
            740                 745                 750         


Met Met Asn Val Ser Arg Asn Asp Ile Ile Arg Tyr Lys Leu Tyr Glu 
        755                 760                 765             


Glu Leu Lys Asp Asn Gly Tyr Lys Thr Leu Tyr Ser Asn Gln Tyr Ile 
    770                 775                 780                 


Pro Lys Glu Lys Ile Phe Ser Lys Glu Ile Asp Ile Glu His Ile Ile 
785                 790                 795                 800 


Pro Gln Ser Arg Leu Phe Asp Asp Ser Leu Ser Asn Lys Thr Leu Glu 
                805                 810                 815     


Tyr Lys Ala Ile Asn Ile Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe 
            820                 825                 830         


Val Lys Glu Lys Tyr Gly Glu Glu Gly Leu Gln Gln Tyr Ile Asn Arg 
        835                 840                 845             


Cys Glu Ser Leu Phe Asn Asp Lys Lys Ala Lys Leu Arg Lys Leu Lys 
    850                 855                 860                 


Met Glu Gln Lys Asp Ile Pro Asp Gly Phe Ile Asp Arg Asp Leu Arg 
865                 870                 875                 880 


Asn Thr Gln Tyr Ile Ala Lys Lys Ala Leu Ala Met Leu Asn Glu Ile 
                885                 890                 895     


Cys Arg Arg Val Val Ala Thr Thr Gly Ser Ile Thr Asp Gln Leu Arg 
            900                 905                 910         


Glu Asp Trp Gln Leu Val Asp Val Met Lys Glu Leu Asn Leu Pro Lys 
        915                 920                 925             


Tyr Glu Ala Leu Gly Phe Val Glu Thr Tyr Glu Asp Lys Asp Gly Arg 
    930                 935                 940                 


Lys Ile Lys Arg Ile Lys Asp Trp Thr Lys Arg Asn Asp His Arg His 
945                 950                 955                 960 


His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Lys Asp Ala Phe Ile 
                965                 970                 975     


Gln Tyr Phe Asn Asn Lys Asn Ala Ala Gln Asp Ser Gly Asn Arg Asn 
            980                 985                 990         


His Thr Asn Ile Ile Gly Ile Lys  Thr Arg Tyr Phe Asp  Lys Gly Arg 
        995                 1000                 1005             


Ala Leu  Pro Pro Ile Pro Leu  Glu Gln Phe Arg Ile  Glu Ala Lys 
    1010                 1015                 1020             


Gln His  Leu Glu Lys Leu Leu  Val Ser Ile Lys Ala  Lys Asn Lys 
    1025                 1030                 1035             


Val Val  Thr Val Asn Val Asn  Arg Thr Lys Lys Arg  Lys Gly Glu 
    1040                 1045                 1050             


Asn Thr  Lys Ile Gln Gln Thr  Pro Arg Gly Gln Leu  His Leu Glu 
    1055                 1060                 1065             


Thr Val  Tyr Gly Ser His Lys  Gln Tyr Val Thr Lys  Ile Glu Lys 
    1070                 1075                 1080             


Val Asn  Ala Ser Phe Asp Ala  Ala Lys Ile Ala Thr  Val Ser Lys 
    1085                 1090                 1095             


Arg Ala  Tyr Arg Asn Ala Leu  Leu Lys Arg Leu Glu  Thr Phe Gly 
    1100                 1105                 1110             


Asn Asp  Pro Lys Lys Ala Phe  Thr Gly Lys Asn Ala  Leu Glu Lys 
    1115                 1120                 1125             


Asn Pro  Leu Tyr Ala Asp Lys  Tyr Gln Thr Ile Arg  Val Pro Glu 
    1130                 1135                 1140             


Lys Val  Gln Thr Val Glu Phe  Glu Thr Ile Tyr Thr  Ile Arg Lys 
    1145                 1150                 1155             


Pro Val  Asp Pro Ala Leu Asn  Val Asp Lys Val Val  Asp Val Lys 
    1160                 1165                 1170             


Val Arg  Ala Ile Leu Glu Arg  Arg Leu Lys Glu Tyr  Gly Gly Asp 
    1175                 1180                 1185             


Pro Lys  Lys Ala Phe Val Asn  Phe Trp Glu Asn Pro  Ile Trp Leu 
    1190                 1195                 1200             


Asn Lys  Glu Lys Gly Ile Ser  Ile Lys Arg Val Ser  Ile Arg Gly 
    1205                 1210                 1215             


Ile Asn  Asn Ala Gln Ser Ile  His Val Lys Lys Asp  Lys Asn Gly 
    1220                 1225                 1230             


Asn Pro  Ile Trp Asp Glu Asn  Gly Lys Gln Ile Pro  Val Asp Phe 
    1235                 1240                 1245             


Val Asn  Thr Gly Asn Asn His  His Val Ala Ile Tyr  Arg Lys Pro 
    1250                 1255                 1260             


Val Leu  Asp Lys Lys Gly Gln  Val Thr Phe Asp Glu  Asp Gly Asn 
    1265                 1270                 1275             


Leu Met  Tyr Glu Leu Asp Glu  Val Val Val Pro Phe  Phe Glu Ala 
    1280                 1285                 1290             


Val Thr  Arg Ala Asn Leu Gly  Leu Pro Ile Ile Asp  Lys Asp Tyr 
    1295                 1300                 1305             


Arg Lys  Ser Glu Gly Trp Gln  Phe Leu Phe Ser Met  Lys Gln Asn 
    1310                 1315                 1320             


Glu Tyr  Phe Val Phe Pro Asn  Glu Lys Thr Gly Phe  Asn Pro Lys 
    1325                 1330                 1335             


Glu Val  Asp Leu Leu Asn Pro  Asp Asn Tyr Ala Met  Ile Ser Pro 
    1340                 1345                 1350             


Asn Leu  Phe Arg Val Gln Thr  Met Ser Lys Val Met  Tyr Gly Asn 
    1355                 1360                 1365             


Asn Val  Val Arg Asp Tyr Lys  Phe Arg His His Leu  Glu Thr Thr 
    1370                 1375                 1380             


Val Lys  Asp Met Lys Glu Leu  Lys Asp Ile Ala Tyr  Lys Gln Tyr 
    1385                 1390                 1395             


Lys Thr  Leu Ser Phe Gly Asn  Ser Val Val Lys Ile  Arg Ile Asn 
    1400                 1405                 1410             


His Ile  Gly Gln Ile Val Ser  Val Gly Glu Tyr 
    1415                 1420                 


<210> 376
<211> 1428
<212> PRT
<213> Parasutterella excrementihominis


<220>
<223> Parasutterella excrementihominis YIT 11859

<400> 376
Met Gly Lys Thr His Ile Ile Gly Val Gly Leu Asp Leu Gly Gly Thr 
1               5                   10                  15      


Tyr Thr Gly Thr Phe Ile Thr Ser His Pro Ser Asp Glu Ala Glu His 
            20                  25                  30          


Arg Asp His Ser Ser Ala Phe Thr Val Val Asn Ser Glu Lys Leu Ser 
        35                  40                  45              


Phe Ser Ser Lys Ser Arg Thr Ala Val Arg His Arg Val Arg Ser Tyr 
    50                  55                  60                  


Lys Gly Phe Asp Leu Arg Arg Arg Leu Leu Leu Leu Val Ala Glu Tyr 
65                  70                  75                  80  


Gln Leu Leu Gln Lys Lys Gln Thr Leu Ala Pro Glu Glu Arg Glu Asn 
                85                  90                  95      


Leu Arg Ile Ala Leu Ser Gly Tyr Leu Lys Arg Arg Gly Tyr Ala Arg 
            100                 105                 110         


Thr Glu Ala Glu Thr Asp Thr Ser Val Leu Glu Ser Leu Asp Pro Ser 
        115                 120                 125             


Val Phe Ser Ser Ala Pro Ser Phe Thr Asn Phe Phe Asn Asp Ser Glu 
    130                 135                 140                 


Pro Leu Asn Ile Gln Trp Glu Ala Ile Ala Asn Ser Pro Glu Thr Thr 
145                 150                 155                 160 


Lys Ala Leu Asn Lys Glu Leu Ser Gly Gln Lys Glu Ala Asp Phe Lys 
                165                 170                 175     


Lys Tyr Ile Lys Thr Ser Phe Pro Glu Tyr Ser Ala Lys Glu Ile Leu 
            180                 185                 190         


Ala Asn Tyr Val Glu Gly Arg Arg Ala Ile Leu Asp Ala Ser Lys Tyr 
        195                 200                 205             


Ile Ala Asn Leu Gln Ser Leu Gly His Lys His Arg Ser Lys Tyr Leu 
    210                 215                 220                 


Ser Asp Ile Leu Gln Asp Met Lys Arg Asp Ser Arg Ile Thr Arg Leu 
225                 230                 235                 240 


Ser Glu Ala Phe Gly Ser Thr Asp Asn Leu Trp Arg Ile Ile Gly Asn 
                245                 250                 255     


Ile Ser Asn Leu Gln Glu Arg Ala Val Arg Trp Tyr Phe Asn Asp Ala 
            260                 265                 270         


Lys Phe Glu Gln Gly Gln Glu Gln Leu Asp Ala Val Lys Leu Lys Asn 
        275                 280                 285             


Val Leu Val Arg Ala Leu Lys Tyr Leu Arg Ser Asp Asp Lys Glu Trp 
    290                 295                 300                 


Ser Ala Ser Gln Lys Gln Ile Ile Gln Ser Leu Glu Gln Ser Gly Asp 
305                 310                 315                 320 


Val Leu Asp Val Leu Ala Gly Leu Asp Pro Asp Arg Thr Ile Pro Pro 
                325                 330                 335     


Tyr Glu Asp Gln Asn Asn Arg Arg Pro Pro Glu Asp Gln Thr Leu Tyr 
            340                 345                 350         


Leu Asn Pro Lys Ala Leu Ser Ser Glu Tyr Gly Glu Lys Trp Lys Ser 
        355                 360                 365             


Trp Ala Asn Lys Phe Ala Gly Ala Tyr Pro Leu Leu Thr Glu Asp Leu 
    370                 375                 380                 


Thr Glu Ile Leu Lys Asn Thr Asp Arg Lys Ser Arg Ile Lys Ile Arg 
385                 390                 395                 400 


Ser Asp Val Leu Pro Asp Ser Asp Tyr Arg Leu Ala Tyr Ile Leu Gln 
                405                 410                 415     


Arg Ala Phe Asp Arg Ser Ile Ala Leu Asp Glu Cys Ser Ile Arg Arg 
            420                 425                 430         


Thr Ala Glu Asp Phe Glu Asn Gly Val Val Ile Lys Asn Glu Lys Leu 
        435                 440                 445             


Glu Asp Val Leu Ser Gly His Gln Leu Glu Glu Phe Leu Glu Phe Ala 
    450                 455                 460                 


Asn Arg Tyr Tyr Gln Glu Thr Ala Lys Ala Lys Asn Gly Leu Trp Phe 
465                 470                 475                 480 


Pro Glu Asn Ala Leu Leu Glu Arg Ala Asp Leu His Pro Pro Met Lys 
                485                 490                 495     


Asn Lys Ile Leu Asn Val Ile Val Gly Gln Ala Leu Gly Val Ser Pro 
            500                 505                 510         


Ala Glu Gly Thr Asp Phe Ile Glu Glu Ile Trp Asn Ser Lys Val Lys 
        515                 520                 525             


Gly Arg Ser Thr Val Arg Ser Ile Cys Asn Ala Ile Glu Asn Glu Arg 
    530                 535                 540                 


Lys Thr Tyr Gly Pro Tyr Phe Ser Glu Asp Tyr Lys Phe Val Lys Thr 
545                 550                 555                 560 


Ala Leu Lys Glu Gly Lys Thr Glu Lys Glu Leu Ser Lys Lys Phe Ala 
                565                 570                 575     


Ala Val Ile Lys Val Leu Lys Met Val Ser Glu Val Val Pro Phe Ile 
            580                 585                 590         


Gly Lys Glu Leu Arg Leu Ser Asp Glu Ala Gln Ser Lys Phe Asp Asn 
        595                 600                 605             


Leu Tyr Ser Leu Ala Gln Leu Tyr Asn Leu Ile Glu Thr Glu Arg Asn 
    610                 615                 620                 


Gly Phe Ser Lys Val Ser Leu Ala Ala His Leu Glu Asn Ala Trp Arg 
625                 630                 635                 640 


Met Thr Met Thr Asp Gly Ser Ala Gln Cys Cys Arg Leu Pro Ala Asp 
                645                 650                 655     


Cys Val Arg Pro Phe Asp Gly Phe Ile Arg Lys Ala Ile Asp Arg Asn 
            660                 665                 670         


Ser Trp Glu Val Ala Lys Arg Ile Ala Glu Glu Val Lys Lys Ser Val 
        675                 680                 685             


Asp Phe Thr Asn Gly Thr Val Lys Ile Pro Val Ala Ile Glu Ala Asn 
    690                 695                 700                 


Ser Phe Asn Phe Thr Ala Ser Leu Thr Asp Leu Lys Tyr Ile Gln Leu 
705                 710                 715                 720 


Lys Glu Gln Lys Leu Lys Lys Lys Leu Glu Asp Ile Gln Arg Asn Glu 
                725                 730                 735     


Glu Asn Gln Glu Lys Arg Trp Leu Ser Lys Glu Glu Arg Ile Arg Ala 
            740                 745                 750         


Asp Ser His Gly Ile Cys Ala Tyr Thr Gly Arg Pro Leu Asp Asp Val 
        755                 760                 765             


Gly Glu Ile Asp His Ile Ile Pro Arg Ser Leu Thr Leu Lys Lys Ser 
    770                 775                 780                 


Glu Ser Ile Tyr Asn Ser Glu Val Asn Leu Ile Phe Val Ser Ala Gln 
785                 790                 795                 800 


Gly Asn Gln Glu Lys Lys Asn Asn Ile Tyr Leu Leu Ser Asn Leu Ala 
                805                 810                 815     


Lys Asn Tyr Leu Ala Ala Val Phe Gly Thr Ser Asp Leu Ser Gln Ile 
            820                 825                 830         


Thr Asn Glu Ile Glu Ser Thr Val Leu Gln Leu Lys Ala Ala Gly Arg 
        835                 840                 845             


Leu Gly Tyr Phe Asp Leu Leu Ser Glu Lys Glu Arg Ala Cys Ala Arg 
    850                 855                 860                 


His Ala Leu Phe Leu Asn Ser Asp Ser Glu Ala Arg Arg Ala Val Ile 
865                 870                 875                 880 


Asp Val Leu Gly Ser Arg Arg Lys Ala Ser Val Asn Gly Thr Gln Ala 
                885                 890                 895     


Trp Phe Val Arg Ser Ile Phe Ser Lys Val Arg Gln Ala Leu Ala Ala 
            900                 905                 910         


Trp Thr Gln Glu Thr Gly Asn Glu Leu Ile Phe Asp Ala Ile Ser Val 
        915                 920                 925             


Pro Ala Ala Asp Ser Ser Glu Met Arg Lys Arg Phe Ala Glu Tyr Arg 
    930                 935                 940                 


Pro Glu Phe Arg Lys Pro Lys Val Gln Pro Val Ala Ser His Ser Ile 
945                 950                 955                 960 


Asp Ala Met Cys Ile Tyr Leu Ala Ala Cys Ser Asp Pro Phe Lys Thr 
                965                 970                 975     


Lys Arg Met Gly Ser Gln Leu Ala Ile Tyr Glu Pro Ile Asn Phe Asp 
            980                 985                 990         


Asn Leu Phe Thr Gly Ser Cys Gln  Val Ile Gln Asn Thr  Pro Arg Asn 
        995                 1000                 1005             


Phe Ser  Asp Lys Thr Asn Ile  Ala Asn Ser Pro Ile  Phe Lys Glu 
    1010                 1015                 1020             


Thr Ile  Tyr Ala Glu Arg Phe  Leu Asp Ile Ile Val  Ser Arg Gly 
    1025                 1030                 1035             


Glu Ile  Phe Ile Gly Tyr Pro  Ser Asn Met Pro Phe  Glu Glu Lys 
    1040                 1045                 1050             


Pro Asn  Arg Ile Ser Ile Gly  Gly Lys Asp Pro Phe  Ser Ile Leu 
    1055                 1060                 1065             


Ser Val  Leu Gly Ala Tyr Leu  Asp Lys Ala Pro Ser  Ser Glu Lys 
    1070                 1075                 1080             


Glu Lys  Leu Thr Ile Tyr Arg  Val Val Lys Asn Lys  Ala Phe Glu 
    1085                 1090                 1095             


Leu Phe  Ser Lys Val Ala Gly  Ser Lys Phe Thr Ala  Glu Glu Asp 
    1100                 1105                 1110             


Lys Ala  Ala Lys Ile Leu Glu  Ala Leu His Phe Val  Thr Val Lys 
    1115                 1120                 1125             


Gln Asp  Val Ala Ala Thr Val  Ser Asp Leu Ile Lys  Ser Lys Lys 
    1130                 1135                 1140             


Glu Leu  Ser Lys Asp Ser Ile  Glu Asn Leu Ala Lys  Gln Lys Gly 
    1145                 1150                 1155             


Cys Leu  Lys Lys Val Glu Tyr  Ser Ser Lys Glu Phe  Lys Phe Lys 
    1160                 1165                 1170             


Gly Ser  Leu Ile Ile Pro Ala  Ala Val Glu Trp Gly  Lys Val Leu 
    1175                 1180                 1185             


Trp Asn  Val Phe Lys Glu Asn  Thr Ala Glu Glu Leu  Lys Asp Glu 
    1190                 1195                 1200             


Asn Ala  Leu Arg Lys Ala Leu  Glu Ala Ala Trp Pro  Ser Ser Phe 
    1205                 1210                 1215             


Gly Thr  Arg Asn Leu His Ser  Lys Ala Lys Arg Val  Phe Ser Leu 
    1220                 1225                 1230             


Pro Val  Val Ala Thr Gln Ser  Gly Ala Val Arg Ile  Arg Arg Lys 
    1235                 1240                 1245             


Thr Ala  Phe Gly Asp Phe Val  Tyr Gln Ser Gln Asp  Thr Asn Asn 
    1250                 1255                 1260             


Leu Tyr  Ser Ser Phe Pro Val  Lys Asn Gly Lys Leu  Asp Trp Ser 
    1265                 1270                 1275             


Ser Pro  Ile Ile His Pro Ala  Leu Gln Asn Arg Asn  Leu Thr Ala 
    1280                 1285                 1290             


Tyr Gly  Tyr Arg Phe Val Asp  His Asp Arg Ser Ile  Ser Met Ser 
    1295                 1300                 1305             


Glu Phe  Arg Glu Val Tyr Asn  Lys Asp Asp Leu Met  Arg Ile Glu 
    1310                 1315                 1320             


Leu Ala  Gln Gly Thr Ser Ser  Arg Arg Tyr Leu Arg  Val Glu Met 
    1325                 1330                 1335             


Pro Gly  Glu Lys Phe Leu Ala  Trp Phe Gly Glu Asn  Ser Ile Ser 
    1340                 1345                 1350             


Leu Gly  Ser Ser Phe Lys Phe  Ser Val Ser Glu Val  Phe Asp Asn 
    1355                 1360                 1365             


Lys Ile  Tyr Thr Glu Asn Ala  Glu Phe Thr Lys Phe  Leu Pro Lys 
    1370                 1375                 1380             


Pro Arg  Glu Asp Asn Lys His  Asn Gly Thr Ile Phe  Phe Glu Leu 
    1385                 1390                 1395             


Val Gly  Pro Arg Val Ile Phe  Asn Tyr Ile Val Gly  Gly Ala Ala 
    1400                 1405                 1410             


Ser Ser  Leu Lys Glu Ile Phe  Ser Glu Ala Gly Lys  Glu Arg Ser 
    1415                 1420                 1425             


<210> 377
<211> 1037
<212> PRT
<213> Parvibaculum lavamentivorans

<400> 377
Met Glu Arg Ile Phe Gly Phe Asp Ile Gly Thr Thr Ser Ile Gly Phe 
1               5                   10                  15      


Ser Val Ile Asp Tyr Ser Ser Thr Gln Ser Ala Gly Asn Ile Gln Arg 
            20                  25                  30          


Leu Gly Val Arg Ile Phe Pro Glu Ala Arg Asp Pro Asp Gly Thr Pro 
        35                  40                  45              


Leu Asn Gln Gln Arg Arg Gln Lys Arg Met Met Arg Arg Gln Leu Arg 
    50                  55                  60                  


Arg Arg Arg Ile Arg Arg Lys Ala Leu Asn Glu Thr Leu His Glu Ala 
65                  70                  75                  80  


Gly Phe Leu Pro Ala Tyr Gly Ser Ala Asp Trp Pro Val Val Met Ala 
                85                  90                  95      


Asp Glu Pro Tyr Glu Leu Arg Arg Arg Gly Leu Glu Glu Gly Leu Ser 
            100                 105                 110         


Ala Tyr Glu Phe Gly Arg Ala Ile Tyr His Leu Ala Gln His Arg His 
        115                 120                 125             


Phe Lys Gly Arg Glu Leu Glu Glu Ser Asp Thr Pro Asp Pro Asp Val 
    130                 135                 140                 


Asp Asp Glu Lys Glu Ala Ala Asn Glu Arg Ala Ala Thr Leu Lys Ala 
145                 150                 155                 160 


Leu Lys Asn Glu Gln Thr Thr Leu Gly Ala Trp Leu Ala Arg Arg Pro 
                165                 170                 175     


Pro Ser Asp Arg Lys Arg Gly Ile His Ala His Arg Asn Val Val Ala 
            180                 185                 190         


Glu Glu Phe Glu Arg Leu Trp Glu Val Gln Ser Lys Phe His Pro Ala 
        195                 200                 205             


Leu Lys Ser Glu Glu Met Arg Ala Arg Ile Ser Asp Thr Ile Phe Ala 
    210                 215                 220                 


Gln Arg Pro Val Phe Trp Arg Lys Asn Thr Leu Gly Glu Cys Arg Phe 
225                 230                 235                 240 


Met Pro Gly Glu Pro Leu Cys Pro Lys Gly Ser Trp Leu Ser Gln Gln 
                245                 250                 255     


Arg Arg Met Leu Glu Lys Leu Asn Asn Leu Ala Ile Ala Gly Gly Asn 
            260                 265                 270         


Ala Arg Pro Leu Asp Ala Glu Glu Arg Asp Ala Ile Leu Ser Lys Leu 
        275                 280                 285             


Gln Gln Gln Ala Ser Met Ser Trp Pro Gly Val Arg Ser Ala Leu Lys 
    290                 295                 300                 


Ala Leu Tyr Lys Gln Arg Gly Glu Pro Gly Ala Glu Lys Ser Leu Lys 
305                 310                 315                 320 


Phe Asn Leu Glu Leu Gly Gly Glu Ser Lys Leu Leu Gly Asn Ala Leu 
                325                 330                 335     


Glu Ala Lys Leu Ala Asp Met Phe Gly Pro Asp Trp Pro Ala His Pro 
            340                 345                 350         


Arg Lys Gln Glu Ile Arg His Ala Val His Glu Arg Leu Trp Ala Ala 
        355                 360                 365             


Asp Tyr Gly Glu Thr Pro Asp Lys Lys Arg Val Ile Ile Leu Ser Glu 
    370                 375                 380                 


Lys Asp Arg Lys Ala His Arg Glu Ala Ala Ala Asn Ser Phe Val Ala 
385                 390                 395                 400 


Asp Phe Gly Ile Thr Gly Glu Gln Ala Ala Gln Leu Gln Ala Leu Lys 
                405                 410                 415     


Leu Pro Thr Gly Trp Glu Pro Tyr Ser Ile Pro Ala Leu Asn Leu Phe 
            420                 425                 430         


Leu Ala Glu Leu Glu Lys Gly Glu Arg Phe Gly Ala Leu Val Asn Gly 
        435                 440                 445             


Pro Asp Trp Glu Gly Trp Arg Arg Thr Asn Phe Pro His Arg Asn Gln 
    450                 455                 460                 


Pro Thr Gly Glu Ile Leu Asp Lys Leu Pro Ser Pro Ala Ser Lys Glu 
465                 470                 475                 480 


Glu Arg Glu Arg Ile Ser Gln Leu Arg Asn Pro Thr Val Val Arg Thr 
                485                 490                 495     


Gln Asn Glu Leu Arg Lys Val Val Asn Asn Leu Ile Gly Leu Tyr Gly 
            500                 505                 510         


Lys Pro Asp Arg Ile Arg Ile Glu Val Gly Arg Asp Val Gly Lys Ser 
        515                 520                 525             


Lys Arg Glu Arg Glu Glu Ile Gln Ser Gly Ile Arg Arg Asn Glu Lys 
    530                 535                 540                 


Gln Arg Lys Lys Ala Thr Glu Asp Leu Ile Lys Asn Gly Ile Ala Asn 
545                 550                 555                 560 


Pro Ser Arg Asp Asp Val Glu Lys Trp Ile Leu Trp Lys Glu Gly Gln 
                565                 570                 575     


Glu Arg Cys Pro Tyr Thr Gly Asp Gln Ile Gly Phe Asn Ala Leu Phe 
            580                 585                 590         


Arg Glu Gly Arg Tyr Glu Val Glu His Ile Trp Pro Arg Ser Arg Ser 
        595                 600                 605             


Phe Asp Asn Ser Pro Arg Asn Lys Thr Leu Cys Arg Lys Asp Val Asn 
    610                 615                 620                 


Ile Glu Lys Gly Asn Arg Met Pro Phe Glu Ala Phe Gly His Asp Glu 
625                 630                 635                 640 


Asp Arg Trp Ser Ala Ile Gln Ile Arg Leu Gln Gly Met Val Ser Ala 
                645                 650                 655     


Lys Gly Gly Thr Gly Met Ser Pro Gly Lys Val Lys Arg Phe Leu Ala 
            660                 665                 670         


Lys Thr Met Pro Glu Asp Phe Ala Ala Arg Gln Leu Asn Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ala Lys Gln Ile Leu Ala Gln Leu Lys Arg Leu Trp Pro Asp 
    690                 695                 700                 


Met Gly Pro Glu Ala Pro Val Lys Val Glu Ala Val Thr Gly Gln Val 
705                 710                 715                 720 


Thr Ala Gln Leu Arg Lys Leu Trp Thr Leu Asn Asn Ile Leu Ala Asp 
                725                 730                 735     


Asp Gly Glu Lys Thr Arg Ala Asp His Arg His His Ala Ile Asp Ala 
            740                 745                 750         


Leu Thr Val Ala Cys Thr His Pro Gly Met Thr Asn Lys Leu Ser Arg 
        755                 760                 765             


Tyr Trp Gln Leu Arg Asp Asp Pro Arg Ala Glu Lys Pro Ala Leu Thr 
    770                 775                 780                 


Pro Pro Trp Asp Thr Ile Arg Ala Asp Ala Glu Lys Ala Val Ser Glu 
785                 790                 795                 800 


Ile Val Val Ser His Arg Val Arg Lys Lys Val Ser Gly Pro Leu His 
                805                 810                 815     


Lys Glu Thr Thr Tyr Gly Asp Thr Gly Thr Asp Ile Lys Thr Lys Ser 
            820                 825                 830         


Gly Thr Tyr Arg Gln Phe Val Thr Arg Lys Lys Ile Glu Ser Leu Ser 
        835                 840                 845             


Lys Gly Glu Leu Asp Glu Ile Arg Asp Pro Arg Ile Lys Glu Ile Val 
    850                 855                 860                 


Ala Ala His Val Ala Gly Arg Gly Gly Asp Pro Lys Lys Ala Phe Pro 
865                 870                 875                 880 


Pro Tyr Pro Cys Val Ser Pro Gly Gly Pro Glu Ile Arg Lys Val Arg 
                885                 890                 895     


Leu Thr Ser Lys Gln Gln Leu Asn Leu Met Ala Gln Thr Gly Asn Gly 
            900                 905                 910         


Tyr Ala Asp Leu Gly Ser Asn His His Ile Ala Ile Tyr Arg Leu Pro 
        915                 920                 925             


Asp Gly Lys Ala Asp Phe Glu Ile Val Ser Leu Phe Asp Ala Ser Arg 
    930                 935                 940                 


Arg Leu Ala Gln Arg Asn Pro Ile Val Gln Arg Thr Arg Ala Asp Gly 
945                 950                 955                 960 


Ala Ser Phe Val Met Ser Leu Ala Ala Gly Glu Ala Ile Met Ile Pro 
                965                 970                 975     


Glu Gly Ser Lys Lys Gly Ile Trp Ile Val Gln Gly Val Trp Ala Ser 
            980                 985                 990         


Gly Gln Val Val Leu Glu Arg Asp  Thr Asp Ala Asp His  Ser Thr Thr 
        995                 1000                 1005             


Thr Arg  Pro Met Pro Asn Pro  Ile Leu Lys Asp Asp  Ala Lys Lys 
    1010                 1015                 1020             


Val Ser  Ile Asp Pro Ile Gly  Arg Val Arg Pro Ser  Asn Asp 
    1025                 1030                 1035         


<210> 378
<211> 1058
<212> PRT
<213> Pasteurella multocida


<220>
<223> Pasteurella multocida subsp. gallicida X73

<400> 378
Met Gln Thr Thr Asn Leu Ser Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Val Val Glu Ile Asn Glu Asn Glu Asp Pro 
            20                  25                  30          


Ile Gly Leu Ile Asp Val Gly Val Arg Ile Phe Glu Arg Ala Glu Val 
        35                  40                  45              


Pro Lys Thr Gly Glu Ser Leu Ala Leu Ser Arg Arg Leu Ala Arg Ser 
    50                  55                  60                  


Thr Arg Arg Leu Ile Arg Arg Arg Ala His Arg Leu Leu Leu Ala Lys 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Glu Gly Ile Leu Ser Thr Thr Asp Leu Glu Lys 
                85                  90                  95      


Gly Leu Pro Asn Gln Ala Trp Glu Leu Arg Val Ala Gly Leu Glu Arg 
            100                 105                 110         


Arg Leu Ser Ala Ile Glu Trp Gly Ala Val Leu Leu His Leu Ile Lys 
        115                 120                 125             


His Arg Gly Tyr Leu Ser Lys Arg Lys Asn Glu Ser Gln Thr Asn Asn 
    130                 135                 140                 


Lys Glu Leu Gly Ala Leu Leu Ser Gly Val Ala Gln Asn His Gln Leu 
145                 150                 155                 160 


Leu Gln Ser Asp Asp Tyr Arg Thr Pro Ala Glu Leu Ala Leu Lys Lys 
                165                 170                 175     


Phe Ala Lys Glu Glu Gly His Ile Arg Asn Gln Arg Gly Ala Tyr Thr 
            180                 185                 190         


His Thr Phe Asn Arg Leu Asp Leu Leu Ala Glu Leu Asn Leu Leu Phe 
        195                 200                 205             


Ala Gln Gln His Gln Phe Gly Asn Pro His Cys Lys Glu His Ile Gln 
    210                 215                 220                 


Gln Tyr Met Thr Glu Leu Leu Met Trp Gln Lys Pro Ala Leu Ser Gly 
225                 230                 235                 240 


Glu Ala Ile Leu Lys Met Leu Gly Lys Cys Thr His Glu Lys Asn Glu 
                245                 250                 255     


Phe Lys Ala Ala Lys His Thr Tyr Ser Ala Glu Arg Phe Val Trp Leu 
            260                 265                 270         


Thr Lys Leu Asn Asn Leu Arg Ile Leu Glu Asp Gly Ala Glu Arg Ala 
        275                 280                 285             


Leu Asn Glu Glu Glu Arg Gln Leu Leu Ile Asn His Pro Tyr Glu Lys 
    290                 295                 300                 


Ser Lys Leu Thr Tyr Ala Gln Val Arg Lys Leu Leu Gly Leu Ser Glu 
305                 310                 315                 320 


Gln Ala Ile Phe Lys His Leu Arg Tyr Ser Lys Glu Ser Ala Glu Ser 
                325                 330                 335     


Ala Thr Phe Met Glu Leu Lys Ala Trp His Ala Ile Arg Lys Ala Leu 
            340                 345                 350         


Glu Asn Gln Gly Leu Lys Asp Thr Trp Gln Asp Leu Ala Lys Lys Pro 
        355                 360                 365             


Asp Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp 
    370                 375                 380                 


Glu Asp Ile Gln Gln Tyr Leu Glu Gly Lys Leu Pro Asp Ser Val Ile 
385                 390                 395                 400 


Asn Ala Leu Leu Val Ser Leu Asn Phe Asp Lys Phe Ile Glu Leu Ser 
                405                 410                 415     


Leu Lys Ser Leu Arg Lys Ile Leu Pro Leu Met Glu Gln Gly Lys Arg 
            420                 425                 430         


Tyr Asp Gln Ala Cys His Glu Ile Tyr Gly His His Tyr Gly Glu Lys 
        435                 440                 445             


Asn Gln Gln Ile Ser Gln Leu Leu Pro Val Ile Pro Thr Gln Glu Ile 
    450                 455                 460                 


Arg Asn Pro Val Val Leu Arg Thr Leu Ser Gln Ala Arg Lys Val Ile 
465                 470                 475                 480 


Asn Ala Ile Ile Arg Gln Tyr Gly Ser Pro Ala Arg Val His Ile Glu 
                485                 490                 495     


Thr Gly Arg Glu Leu Gly Lys Ser Phe Lys Glu Arg Arg Glu Ile Gln 
            500                 505                 510         


Lys Gln Gln Glu Asp Asn Arg Thr Lys Arg Glu Ser Ala Val Gln Lys 
        515                 520                 525             


Phe Lys Glu Leu Phe Ser Asp Phe Ser Ser Glu Pro Lys Ser Lys Asp 
    530                 535                 540                 


Ile Leu Lys Phe Arg Leu Tyr Glu Gln Gln His Gly Lys Cys Leu Tyr 
545                 550                 555                 560 


Ser Gly Lys Glu Ile Asn Ile His Arg Leu Asn Glu Lys Gly Tyr Val 
                565                 570                 575     


Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe 
            580                 585                 590         


Asn Asn Lys Val Leu Val Leu Ala Ser Glu Asn Gln Asn Lys Gly Asn 
        595                 600                 605             


Gln Thr Pro Tyr Glu Trp Leu Gln Gly Lys Ile Asn Ser Glu Arg Trp 
    610                 615                 620                 


Lys Asn Phe Val Ala Leu Val Leu Gly Ser Gln Cys Ser Ala Ala Lys 
625                 630                 635                 640 


Lys Gln Arg Leu Leu Thr Gln Val Ile Asp Asp Asn Lys Phe Ile Asp 
                645                 650                 655     


Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Arg Phe Leu Ser Asn Tyr 
            660                 665                 670         


Ile Gln Glu Asn Leu Leu Leu Val Gly Lys Asn Lys Lys Asn Val Phe 
        675                 680                 685             


Thr Pro Asn Gly Gln Ile Thr Ala Leu Leu Arg Ser Arg Trp Gly Leu 
    690                 695                 700                 


Ile Lys Val Arg Glu Asn Asn Asp Arg His His Ala Leu Asp Ala Ile 
705                 710                 715                 720 


Val Val Ala Cys Ala Thr Pro Ser Met Gln Gln Lys Ile Thr Arg Phe 
                725                 730                 735     


Ile Arg Phe Lys Glu Val His Pro Tyr Lys Ile Glu Asn Arg Tyr Glu 
            740                 745                 750         


Met Val Asp Gln Glu Ser Gly Glu Ile Ile Ser Pro His Phe Pro Glu 
        755                 760                 765             


Pro Trp Ala Tyr Phe Arg Gln Glu Val Asn Ile Arg Val Phe Asp Asn 
    770                 775                 780                 


His Pro Asp Thr Val Leu Lys Glu Met Leu Pro Asp Arg Pro Gln Ala 
785                 790                 795                 800 


Asn His Gln Phe Val Gln Pro Leu Phe Val Ser Arg Ala Pro Thr Arg 
                805                 810                 815     


Lys Met Ser Gly Gln Gly His Met Glu Thr Ile Lys Ser Ala Lys Arg 
            820                 825                 830         


Leu Ala Glu Gly Ile Ser Val Leu Arg Ile Pro Leu Thr Gln Leu Lys 
        835                 840                 845             


Pro Asn Leu Leu Glu Asn Met Val Asn Lys Glu Arg Glu Pro Ala Leu 
    850                 855                 860                 


Tyr Val Gly Leu Lys Ala Arg Leu Ala Glu Phe Asn Gln Asp Pro Ala 
865                 870                 875                 880 


Lys Ala Phe Ala Thr Pro Phe Tyr Lys Gln Gly Gly Gln Gln Val Lys 
                885                 890                 895     


Ala Ile Arg Val Glu Leu Val Gln Lys Ser Gly Val Leu Val Arg Gln 
            900                 905                 910         


Gly Asn Gly Val Ala Asp Asn Ala Pro Gly Ser Ile Val Arg Thr Asp 
        915                 920                 925             


Val Phe Ile Lys Asn Asn Lys Phe Phe Leu Val Pro Ile Tyr Thr Trp 
    930                 935                 940                 


Gln Val Ala Lys Gly Ile Leu Pro Asn Lys Ala Ile Val Ala His Lys 
945                 950                 955                 960 


Asn Glu Asp Glu Trp Glu Glu Met Asp Glu Gly Ala Lys Phe Lys Phe 
                965                 970                 975     


Ser Ile Phe Pro Asn Asp Leu Ile Glu Leu Arg Thr Lys Thr Glu Cys 
            980                 985                 990         


Phe Leu Gly Tyr Tyr Ile Gly Pro  Asp Arg His Asn Gly  Ser Ile Ser 
        995                 1000                 1005             


Leu Arg  Glu His Asp Ser Glu  Ile Ser Lys Gly Asn  Ala Gly Val 
    1010                 1015                 1020             


Tyr Arg  Val Gly Val Lys Leu  Ala Leu Ser Leu Glu  Lys Tyr His 
    1025                 1030                 1035             


Ile Asp  Glu Leu Gly Lys Asn  Arg Arg Ile Cys Arg  Pro His Gln 
    1040                 1045                 1050             


Arg Arg  Pro Val Arg 
    1055             


<210> 379
<211> 1056
<212> PRT
<213> Pasteurella multocida


<220>
<223> Pasteurella multocida subsp. multocida str. P52VAC

<400> 379
Met Gln Thr Thr Asn Leu Ser Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Val Val Glu Ile Asn Glu Asn Glu Asp Pro 
            20                  25                  30          


Ile Gly Leu Ile Asp Val Gly Val Arg Ile Phe Glu Arg Ala Glu Val 
        35                  40                  45              


Pro Lys Thr Gly Glu Ser Leu Ala Leu Ser Arg Arg Leu Ala Arg Ser 
    50                  55                  60                  


Thr Arg Arg Leu Ile Arg Arg Arg Ala Arg Arg Leu Leu Leu Ala Lys 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Glu Gly Ile Leu Ser Thr Thr Asp Leu Glu Lys 
                85                  90                  95      


Gly Leu Pro Asn Gln Ala Trp Glu Leu Arg Val Ala Gly Leu Glu Arg 
            100                 105                 110         


Arg Leu Ser Ala Ile Glu Trp Gly Ala Val Leu Leu His Leu Ile Lys 
        115                 120                 125             


His Arg Gly Tyr Leu Ser Lys Arg Lys Asn Glu Ser Gln Thr Asn Asn 
    130                 135                 140                 


Lys Glu Leu Gly Ala Leu Leu Ser Gly Val Ala Gln Asn His Gln Leu 
145                 150                 155                 160 


Leu Gln Ser Asp Asp Tyr Arg Thr Pro Ala Glu Leu Ala Leu Lys Lys 
                165                 170                 175     


Phe Ala Lys Glu Glu Gly His Ile Arg Asn Gln Arg Gly Ala Tyr Thr 
            180                 185                 190         


His Thr Phe Asn Arg Leu Asp Leu Leu Ala Glu Leu Asn Leu Leu Phe 
        195                 200                 205             


Ala Gln Gln His Gln Phe Gly Asn Pro His Cys Lys Glu His Ile Gln 
    210                 215                 220                 


Gln Tyr Met Thr Glu Leu Leu Met Trp Gln Lys Pro Ala Leu Ser Gly 
225                 230                 235                 240 


Glu Ala Ile Leu Lys Met Leu Gly Lys Cys Thr His Glu Lys Asn Glu 
                245                 250                 255     


Phe Lys Ala Ala Lys His Thr Tyr Ser Ala Glu Arg Phe Val Trp Leu 
            260                 265                 270         


Thr Lys Leu Asn Asn Leu Arg Ile Leu Glu Asp Gly Ala Glu Arg Ala 
        275                 280                 285             


Leu Asn Glu Glu Glu Arg Gln Leu Leu Ile Asn His Pro Tyr Glu Lys 
    290                 295                 300                 


Ser Lys Leu Thr Tyr Ala Gln Val Arg Lys Leu Leu Gly Leu Ser Glu 
305                 310                 315                 320 


Gln Ala Ile Phe Lys His Leu Arg Tyr Ser Lys Glu Asn Ala Glu Ser 
                325                 330                 335     


Ala Thr Phe Met Glu Leu Lys Ala Trp His Ala Ile Arg Lys Ala Leu 
            340                 345                 350         


Glu Asn Gln Gly Leu Lys Asp Thr Trp Gln Asp Leu Ala Lys Lys Pro 
        355                 360                 365             


Asp Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp 
    370                 375                 380                 


Glu Asp Ile Gln Gln Tyr Leu Thr Asn Lys Val Pro Asn Ser Val Ile 
385                 390                 395                 400 


Asn Ala Leu Leu Val Phe Leu Asn Phe Asp Lys Phe Ile Glu Leu Ala 
                405                 410                 415     


Leu Lys Ser Leu Arg Lys Ile Leu Pro Leu Met Glu Gln Gly Lys Arg 
            420                 425                 430         


Tyr Asp Gln Ala Cys Arg Glu Ile Tyr Gly His His Tyr Gly Glu Ala 
        435                 440                 445             


Asn Gln Lys Thr Ser Gln Leu Leu Pro Ala Ile Pro Ala Gln Glu Ile 
    450                 455                 460                 


Arg Asn Pro Val Val Leu Arg Thr Leu Ser Gln Ala Arg Lys Val Ile 
465                 470                 475                 480 


Asn Ala Ile Ile Arg Gln Tyr Gly Ser Pro Ala Arg Val His Ile Glu 
                485                 490                 495     


Thr Gly Arg Glu Leu Gly Lys Ser Phe Lys Glu Arg Arg Glu Ile Gln 
            500                 505                 510         


Lys Gln Gln Glu Asp Asn Arg Thr Lys Arg Glu Ser Ala Val Gln Lys 
        515                 520                 525             


Phe Lys Glu Leu Phe Ser Asp Phe Ser Ser Glu Pro Lys Ser Lys Asp 
    530                 535                 540                 


Ile Leu Lys Phe Arg Leu Tyr Glu Gln Gln His Gly Lys Cys Leu Tyr 
545                 550                 555                 560 


Ser Gly Lys Glu Ile Asn Ile His Arg Leu Asn Glu Lys Gly Tyr Val 
                565                 570                 575     


Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe 
            580                 585                 590         


Asn Asn Lys Val Leu Val Leu Ala Ser Glu Asn Gln Asn Lys Gly Asn 
        595                 600                 605             


Gln Thr Pro Tyr Glu Trp Leu Gln Gly Lys Ile Asn Ser Glu Arg Trp 
    610                 615                 620                 


Lys Asn Phe Val Ala Leu Val Leu Gly Ser Gln Cys Ser Ala Ala Lys 
625                 630                 635                 640 


Lys Gln Arg Leu Leu Thr Gln Val Ile Asp Asp Asn Lys Phe Ile Asp 
                645                 650                 655     


Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Arg Phe Leu Ser Asn Tyr 
            660                 665                 670         


Ile Gln Glu Asn Leu Leu Leu Val Gly Lys Asn Lys Lys Asn Val Phe 
        675                 680                 685             


Thr Pro Asn Gly Gln Ile Thr Ala Leu Leu Arg Ser Arg Trp Gly Leu 
    690                 695                 700                 


Ile Lys Ile Arg Glu Asn Asn Asp Arg His His Ala Leu Asp Ala Ile 
705                 710                 715                 720 


Val Val Ala Cys Ala Thr Pro Ser Met Gln Gln Lys Ile Thr Arg Phe 
                725                 730                 735     


Ile Arg Phe Lys Glu Val His Pro Tyr Lys Ile Glu Asn Arg Tyr Glu 
            740                 745                 750         


Met Val Asp Gln Glu Ser Gly Glu Ile Ile Ser Pro His Phe Pro Glu 
        755                 760                 765             


Pro Trp Ala Tyr Phe Arg Gln Glu Val Asn Ile Arg Val Phe Asp Asn 
    770                 775                 780                 


His Pro Asp Thr Val Leu Lys Glu Met Leu Pro Asp Arg Pro Gln Ala 
785                 790                 795                 800 


Asn His Gln Phe Val Gln Pro Leu Phe Val Ser Arg Ala Pro Thr Arg 
                805                 810                 815     


Lys Met Ser Gly Gln Gly His Met Glu Thr Ile Lys Ser Ala Lys Arg 
            820                 825                 830         


Leu Ala Glu Gly Ile Ser Val Leu Arg Ile Pro Leu Thr Gln Leu Lys 
        835                 840                 845             


Pro Asn Leu Leu Glu Asn Met Val Asn Lys Glu Arg Glu Pro Ala Leu 
    850                 855                 860                 


Tyr Ala Gly Leu Lys Ala Arg Leu Ala Glu Phe Asn Gln Asp Pro Ala 
865                 870                 875                 880 


Lys Ala Phe Thr Thr Pro Phe Tyr Lys Gln Gly Gly Gln Gln Val Lys 
                885                 890                 895     


Ala Ile Arg Val Glu Gln Val Gln Lys Ser Gly Val Leu Val Arg Glu 
            900                 905                 910         


Asn Asn Gly Val Ala Asp Asn Ala Ser Ile Val Arg Thr Asp Val Phe 
        915                 920                 925             


Ile Lys Asn Asn Lys Phe Phe Leu Val Pro Ile Tyr Thr Trp Gln Val 
    930                 935                 940                 


Ala Lys Gly Ile Leu Pro Asn Lys Ala Ile Val Ala His Lys Asn Glu 
945                 950                 955                 960 


Asp Glu Trp Glu Glu Met Asp Glu Gly Ala Lys Phe Lys Phe Ser Leu 
                965                 970                 975     


Phe Pro Asn Asp Leu Val Glu Leu Lys Thr Lys Lys Glu Tyr Phe Phe 
            980                 985                 990         


Gly Tyr Tyr Ile Gly Leu Asp Arg  Ala Thr Gly Asn Ile  Ser Leu Lys 
        995                 1000                 1005             


Glu His  Asp Gly Glu Ile Ser  Lys Gly Lys Asp Gly  Val Tyr Arg 
    1010                 1015                 1020             


Val Gly  Val Lys Leu Ala Leu  Ser Phe Glu Lys Tyr  Gln Val Asp 
    1025                 1030                 1035             


Glu Leu  Gly Lys Asn Arg Gln  Ile Cys Arg Pro Gln  Gln Arg Gln 
    1040                 1045                 1050             


Pro Val  Arg 
    1055     


<210> 380
<211> 1056
<212> PRT
<213> Pasteurella multocida

<400> 380
Met Gln Thr Thr Asn Leu Ser Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Val Val Glu Ile Asn Glu Asn Glu Asp Pro 
            20                  25                  30          


Ile Gly Leu Ile Asp Val Gly Val Arg Ile Phe Glu Arg Ala Glu Val 
        35                  40                  45              


Pro Lys Thr Gly Glu Ser Leu Ala Leu Ser Arg Arg Leu Ala Arg Ser 
    50                  55                  60                  


Thr Arg Arg Leu Ile Arg Arg Arg Ala His Arg Leu Leu Leu Ala Lys 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Glu Gly Ile Leu Ser Thr Ile Asp Leu Glu Lys 
                85                  90                  95      


Gly Leu Pro Asn Gln Ala Trp Glu Leu Arg Val Ala Gly Leu Glu Arg 
            100                 105                 110         


Arg Leu Ser Ala Ile Glu Trp Gly Ala Val Leu Leu His Leu Ile Lys 
        115                 120                 125             


His Arg Gly Tyr Leu Ser Lys Arg Lys Asn Glu Ser Gln Thr Asn Asn 
    130                 135                 140                 


Lys Glu Leu Gly Ala Leu Leu Ser Gly Val Ala Gln Asn His Gln Leu 
145                 150                 155                 160 


Leu Gln Ser Asp Asp Tyr Arg Thr Pro Ala Glu Leu Ala Leu Lys Lys 
                165                 170                 175     


Phe Ala Lys Glu Glu Gly His Ile Arg Asn Gln Arg Gly Ala Tyr Thr 
            180                 185                 190         


His Thr Phe Asn Arg Leu Asp Leu Leu Ala Glu Leu Asn Leu Leu Phe 
        195                 200                 205             


Ala Gln Gln His Gln Phe Gly Asn Pro His Cys Lys Glu His Ile Gln 
    210                 215                 220                 


Gln Tyr Met Thr Glu Leu Leu Met Trp Gln Lys Pro Ala Leu Ser Gly 
225                 230                 235                 240 


Glu Ala Ile Leu Lys Met Leu Gly Lys Cys Thr His Glu Lys Asn Glu 
                245                 250                 255     


Phe Lys Ala Ala Lys His Thr Tyr Ser Ala Glu Arg Phe Val Trp Leu 
            260                 265                 270         


Thr Lys Leu Asn Asn Leu Arg Ile Leu Glu Asp Gly Ala Glu Arg Ala 
        275                 280                 285             


Leu Asn Glu Glu Glu Arg Gln Leu Leu Ile Asn His Pro Tyr Glu Lys 
    290                 295                 300                 


Ser Lys Leu Thr Tyr Ala Gln Val Arg Lys Leu Leu Gly Leu Ser Glu 
305                 310                 315                 320 


Gln Ala Ile Phe Lys His Leu Arg Tyr Ser Lys Glu Asn Ala Glu Ser 
                325                 330                 335     


Ala Thr Phe Met Glu Leu Lys Ala Trp His Ala Ile Arg Lys Ala Leu 
            340                 345                 350         


Glu Asn Gln Gly Leu Lys Asp Thr Trp Gln Asp Leu Ala Lys Lys Pro 
        355                 360                 365             


Asp Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp 
    370                 375                 380                 


Glu Asp Ile Gln Gln Tyr Leu Thr Asn Lys Val Pro Asn Ser Val Ile 
385                 390                 395                 400 


Asn Ala Leu Leu Val Ser Leu Asn Phe Asp Lys Phe Ile Glu Leu Ser 
                405                 410                 415     


Leu Lys Ser Leu Arg Lys Ile Leu Pro Leu Met Glu Gln Gly Lys Arg 
            420                 425                 430         


Tyr Asp Gln Ala Cys Arg Glu Ile Tyr Gly His His Tyr Gly Glu Ala 
        435                 440                 445             


Asn Gln Lys Thr Ser Gln Leu Leu Pro Ala Ile Pro Ala Gln Glu Ile 
    450                 455                 460                 


Arg Asn Pro Val Val Leu Arg Thr Leu Ser Gln Ala Arg Lys Val Ile 
465                 470                 475                 480 


Asn Ala Ile Ile Arg Gln Tyr Gly Ser Pro Ala Arg Val His Ile Glu 
                485                 490                 495     


Thr Gly Arg Glu Leu Gly Lys Ser Phe Lys Glu Arg Arg Glu Ile Gln 
            500                 505                 510         


Lys Gln Gln Glu Asp Asn Arg Thr Lys Arg Glu Ser Ala Val Gln Lys 
        515                 520                 525             


Phe Lys Glu Leu Phe Ser Asp Phe Ser Ser Glu Pro Lys Ser Lys Asp 
    530                 535                 540                 


Ile Leu Lys Phe Arg Leu Tyr Glu Gln Gln His Gly Lys Cys Leu Tyr 
545                 550                 555                 560 


Ser Gly Lys Glu Ile Asn Ile His Arg Leu Asn Glu Lys Gly Tyr Val 
                565                 570                 575     


Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe 
            580                 585                 590         


Asn Asn Lys Val Leu Val Leu Ala Ser Glu Asn Gln Asn Lys Gly Asn 
        595                 600                 605             


Gln Thr Pro Tyr Glu Trp Leu Gln Gly Lys Ile Asn Ser Glu Arg Trp 
    610                 615                 620                 


Lys Asn Phe Val Ala Leu Val Leu Gly Ser Gln Cys Ser Ala Ala Lys 
625                 630                 635                 640 


Lys Gln Arg Leu Leu Thr Gln Val Ile Asp Asp Asn Lys Phe Ile Asp 
                645                 650                 655     


Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Arg Phe Leu Ser Asn Tyr 
            660                 665                 670         


Ile Gln Glu Asn Leu Leu Leu Val Gly Lys Asn Lys Lys Asn Val Phe 
        675                 680                 685             


Thr Pro Asn Gly Gln Ile Thr Ala Leu Leu Arg Ser Arg Trp Gly Leu 
    690                 695                 700                 


Ile Lys Ala Arg Glu Asn Asn Asn Arg His His Ala Leu Asp Ala Ile 
705                 710                 715                 720 


Val Val Ala Cys Ala Thr Pro Ser Met Gln Gln Lys Ile Thr Arg Phe 
                725                 730                 735     


Ile Arg Phe Lys Glu Val His Pro Tyr Lys Ile Glu Asn Arg Tyr Glu 
            740                 745                 750         


Met Val Asp Gln Glu Ser Gly Glu Ile Ile Ser Pro His Phe Pro Glu 
        755                 760                 765             


Pro Trp Ala Tyr Phe Arg Gln Glu Val Asn Ile Arg Val Phe Asp Asn 
    770                 775                 780                 


His Pro Asp Thr Val Leu Lys Glu Met Leu Pro Asp Arg Pro Gln Ala 
785                 790                 795                 800 


Asn His Gln Phe Val Gln Pro Leu Phe Val Ser Arg Ala Pro Thr Arg 
                805                 810                 815     


Lys Met Ser Gly Gln Gly His Met Glu Thr Ile Lys Ser Ala Lys Arg 
            820                 825                 830         


Leu Ala Glu Gly Ile Ser Val Leu Arg Ile Pro Leu Thr Gln Leu Lys 
        835                 840                 845             


Pro Asn Leu Leu Glu Asn Met Val Asn Lys Glu Arg Glu Pro Ala Leu 
    850                 855                 860                 


Tyr Ala Gly Leu Lys Ala Arg Leu Ala Glu Phe Asn Gln Asp Pro Ala 
865                 870                 875                 880 


Lys Ala Phe Ala Thr Pro Phe Tyr Lys Gln Gly Gly Gln Gln Val Lys 
                885                 890                 895     


Ala Ile Arg Val Glu Gln Val Gln Lys Ser Gly Val Leu Val Arg Glu 
            900                 905                 910         


Asn Asn Gly Val Ala Asp Asn Ala Ser Ile Val Arg Thr Asp Val Phe 
        915                 920                 925             


Ile Lys Asn Asn Lys Phe Phe Leu Val Pro Ile Tyr Thr Trp Gln Val 
    930                 935                 940                 


Ala Lys Gly Ile Leu Pro Asn Lys Ala Ile Val Ala His Lys Asn Glu 
945                 950                 955                 960 


Asp Glu Trp Glu Glu Met Asp Glu Gly Ala Lys Phe Lys Phe Ser Leu 
                965                 970                 975     


Phe Pro Asn Asp Leu Val Glu Leu Lys Thr Lys Lys Glu Tyr Phe Phe 
            980                 985                 990         


Gly Tyr Tyr Ile Gly Leu Asp Arg  Ala Thr Gly Asn Ile  Ser Leu Lys 
        995                 1000                 1005             


Glu His  Asp Gly Glu Ile Ser  Lys Gly Lys Asp Gly  Val Tyr Arg 
    1010                 1015                 1020             


Val Gly  Val Lys Leu Ala Leu  Ser Phe Glu Lys Tyr  Gln Val Asp 
    1025                 1030                 1035             


Glu Leu  Gly Lys Asn Arg Gln  Ile Cys Arg Pro Gln  Gln Arg Gln 
    1040                 1045                 1050             


Pro Val  Arg 
    1055     


<210> 381
<211> 1364
<212> PRT
<213> Pediococcus acidilactici


<220>
<223> Pediococcus acidilactici DSM 20284

<400> 381
Met Gly Asp Arg Lys Tyr Asn Leu Gly Leu Asp Ile Gly Thr Ser Ser 
1               5                   10                  15      


Ile Gly Phe Ala Ala Val Asp Glu Asn Asn Gln Pro Ile Arg Val Lys 
            20                  25                  30          


Gly Lys Thr Ala Ile Gly Val Arg Leu Phe Glu Glu Gly Lys Thr Ala 
        35                  40                  45              


Ala Asp Arg Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg 
    50                  55                  60                  


Arg Trp Arg Ile Asn Leu Leu Asn Glu Ile Phe Asp Ala His Leu Ala 
65                  70                  75                  80  


Glu Val Asp Pro Thr Phe Leu Ala Arg Leu Lys Glu Ser Asn Arg Ser 
                85                  90                  95      


Asn Leu Asp Pro Lys Lys Ser Phe Gln Gly Ser Leu Leu Phe Pro Glu 
            100                 105                 110         


Arg Lys Asp Tyr Gln Phe Tyr Glu Glu Tyr Pro Thr Ile Tyr His Leu 
        115                 120                 125             


Arg Lys Ala Leu Met Glu Lys Asp Arg Lys Phe Asp Phe Arg Glu Ile 
    130                 135                 140                 


Tyr Leu Ala Val His His Ile Ile Lys Tyr Arg Gly Asn Phe Leu Asn 
145                 150                 155                 160 


Gly Thr Pro Met Arg Ser Phe Lys Val Glu Asn Ile Glu Leu Asp Thr 
                165                 170                 175     


Leu Phe Asp Gln Leu Asn Gln Leu Tyr Ala Glu Ile Val Pro Asp Asn 
            180                 185                 190         


Glu Leu Ala Phe Asp Leu Ala Gln Val Ala Asp Val Lys Asp Val Leu 
        195                 200                 205             


Ser Ser Thr Thr Ile Tyr Lys Met Asp Lys Lys Lys Gln Leu Val Lys 
    210                 215                 220                 


Met Met Leu Leu Pro Ala Ser Asn Lys Ala Leu Gln Ser Glu Asn Lys 
225                 230                 235                 240 


Lys Ile Val Thr Gln Phe Val Asn Ala Ile Leu Asn Tyr Lys Phe Lys 
                245                 250                 255     


Leu Asp Val Leu Leu Gln Val Glu Thr Asp Ala Asp Trp Ser Leu Lys 
            260                 265                 270         


Leu Asn Asp Glu Gly Ala Asp Asp Lys Leu Glu Glu Phe Thr Gly Asp 
        275                 280                 285             


Leu Asp Glu Asn Arg Leu Glu Ile Ile Asp Leu Leu Gln Arg Leu His 
    290                 295                 300                 


Asn Trp Phe Ser Leu Asn Glu Ile Thr Lys Asp Gly Asn Ser Leu Ser 
305                 310                 315                 320 


Ala Ala Met Val Glu Lys Tyr Glu Asn His His His His Leu Gly Leu 
                325                 330                 335     


Leu Lys Lys Val Ile Glu Asn His Pro Asp Ala Lys Lys Ala Lys Ala 
            340                 345                 350         


Leu Lys Glu Thr Tyr Thr Ala Tyr Val Gly Lys Thr Asp Asp Lys Thr 
        355                 360                 365             


Gln Asn Gln Asp Asp Phe Tyr Lys Ala Val Glu Lys Asn Leu Asp Asp 
    370                 375                 380                 


Ser Pro Asp Ala Lys Glu Ile Lys Arg Leu Ile Gln Leu Asp Gln Phe 
385                 390                 395                 400 


Met Pro Lys Gln Arg Thr Gly Gln Asn Gly Ala Ile Pro His Gln Leu 
                405                 410                 415     


His Gln Gln Glu Leu Asp Gln Ile Ile Glu Lys Gln Ser Lys Tyr Tyr 
            420                 425                 430         


Pro Phe Leu Ala Glu Pro Asn Pro Asn Val Lys Arg Arg Lys Asp Ala 
        435                 440                 445             


Pro Tyr Lys Leu Asp Glu Leu Ile Ala Phe Lys Ile Pro Tyr Tyr Val 
    450                 455                 460                 


Gly Pro Leu Val Thr Pro Glu Glu Gln Ala Gln Asn Gly Glu Asn Val 
465                 470                 475                 480 


Phe Ala Trp Met Lys Arg Lys Ala Ala Gly Pro Ile Thr Pro Trp Asn 
                485                 490                 495     


Phe Asp Glu Lys Val Asp Arg Met Glu Ser Ala Asn Arg Phe Ile Arg 
            500                 505                 510         


Arg Met Thr Thr Lys Asp Thr Tyr Leu Phe Gly Glu Asp Val Leu Pro 
        515                 520                 525             


Ala Glu Ser Met Ile Tyr Gln Lys Phe Val Val Leu Asn Glu Leu Asn 
    530                 535                 540                 


Asn Leu Lys Ile Asn Gly Arg His Leu Ser Leu Lys Asp Lys Gln Asp 
545                 550                 555                 560 


Val Tyr Asn Asp Leu Phe Lys Gln Gln Lys Thr Val Ser Ile Lys Ala 
                565                 570                 575     


Leu Gln Asn Tyr Tyr Val Thr Lys Lys Lys Ala Ala Thr Ala Pro Thr 
            580                 585                 590         


Val Gly Gly Leu Ala Asp Pro Lys Lys Phe Leu Ser Ser Leu Ser Thr 
        595                 600                 605             


Tyr Ile Asp Phe Lys Asn Met Phe Gly Glu Arg Val Asn Asp Pro Gln 
    610                 615                 620                 


Phe Gln Glu Asp Leu Glu Gln Ile Val Glu Trp Ser Thr Ile Phe Glu 
625                 630                 635                 640 


Asp Arg Gly Ile Phe Lys Ala Lys Leu Gln Ala Leu Gly Trp Leu Ser 
                645                 650                 655     


Glu Lys Gln Ile Gln Gln Leu Val Ala Lys Arg Tyr Lys Gly Trp Gly 
            660                 665                 670         


Arg Leu Ser Lys Lys Leu Leu Thr Gly Leu Lys Asn Ala Glu Gly Tyr 
        675                 680                 685             


Ser Ile Leu Asp Glu Met Trp Arg Ser Thr Gly Asn Phe Met Gln Ile 
    690                 695                 700                 


Gln Ser Arg Pro Glu Phe Ala Ala Leu Ile Gln Gln Ala Asn Glu Lys 
705                 710                 715                 720 


Gln Phe Glu Gly Asn Asp Pro Asp Asn Val Trp Glu Asn Ile Glu Asn 
                725                 730                 735     


Ile Leu Gly Asp Ala Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile Arg 
            740                 745                 750         


Gln Val Val Lys Val Val Gln Asp Ile Glu Lys Ala Val Gly Asn Pro 
        755                 760                 765             


Pro Glu Lys Ile Ala Ile Glu Phe Thr Arg Glu Ala Ala Ala Asn Pro 
    770                 775                 780                 


Gln Arg Thr Gln Ser Arg Leu Arg Thr Leu Glu Lys Leu Tyr Glu Ser 
785                 790                 795                 800 


Ala Glu Glu Val Val Asp Ala Gly Leu Thr Ala Glu Leu Ala Glu Phe 
                805                 810                 815     


Lys Glu Asn Lys His Val Leu Ser Asp Lys Tyr Tyr Leu Tyr Phe Thr 
            820                 825                 830         


Gln Leu Gly Arg Asp Val Tyr Thr Gly Asp Thr Ile Ser Leu Asp Lys 
        835                 840                 845             


Leu Asn Asp Tyr Asp Val Asp His Ile Leu Pro Gln Ser Phe Ile Lys 
    850                 855                 860                 


Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ile Arg Ala Val Asn Asn 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ala Lys Met Phe Gly Lys Lys Met Gly 
                885                 890                 895     


Ser Phe Trp Arg Tyr Leu Leu Asp Asn Gly Met Ile Ser Lys Arg Lys 
            900                 905                 910         


Tyr Asn Asn Leu Ile Thr Asp Pro Asp Asn Ile Ser Lys Tyr Ala Gln 
        915                 920                 925             


Lys Gly Phe Ile Asn Arg Gln Leu Val Glu Thr Ser Gln Val Ile Lys 
    930                 935                 940                 


Leu Thr Ala Asn Ile Leu Asn Gly Ile Tyr Asp Lys Asp Thr Glu Ile 
945                 950                 955                 960 


Ile Glu Val Pro Ala Lys Met Asn Ser Gln Met Arg Lys Met Phe Asp 
                965                 970                 975     


Leu Val Lys Val Arg Glu Val Asn Asp Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Tyr Leu Thr Ile Phe Ile Gly Asn  Tyr Leu Tyr Lys Cys  Tyr Pro Lys 
        995                 1000                 1005             


Leu Gln  Pro Tyr Phe Val Tyr  Asp Asn Phe Lys Lys  Phe Gly Asn 
    1010                 1015                 1020             


Lys Glu  Asp Ile Gly His Lys  Arg Phe Asn Phe Leu  Gly Lys Ile 
    1025                 1030                 1035             


Glu Arg  Glu Lys Lys Val Val  Ala Pro Glu Thr Gly  Glu Ile Leu 
    1040                 1045                 1050             


Trp Ser  Asn Val Ala Pro Asn  Glu Thr Ile Lys Gln  Ile Lys Lys 
    1055                 1060                 1065             


Val Tyr  Asp Tyr Lys Phe Met  Ile Val Ser Arg Glu  Ile Thr Thr 
    1070                 1075                 1080             


Arg Arg  Ala Glu Leu Phe Asn  Gln Thr Val Tyr Pro  Lys Asn Tyr 
    1085                 1090                 1095             


His Gly  Lys Leu Ile Pro Ile  Lys Glu Asp Arg Pro  Thr Asp Leu 
    1100                 1105                 1110             


Tyr Gly  Gly Tyr Ser Gly Asn  Thr Asp Ala Tyr Leu  Ala Ile Val 
    1115                 1120                 1125             


Ala Leu  Glu Asp Lys Lys Lys  Gly Lys Tyr Phe Lys  Val Val Gly 
    1130                 1135                 1140             


Ile Pro  Thr Arg Val Ala Ala  Lys Leu Glu Lys Leu  Lys Gln Gln 
    1145                 1150                 1155             


Asp Ser  Gln Gln Tyr Leu Gln  Ala Leu His Lys Val  Ile Ala Pro 
    1160                 1165                 1170             


Gln Phe  Thr Lys Ser Thr Lys  Lys Gly Ile Lys Lys  Thr Glu Phe 
    1175                 1180                 1185             


Glu Ile  Val Leu Asp Lys Val  His Tyr Arg Gln Leu  Val Gln Asp 
    1190                 1195                 1200             


Gly Pro  Val Lys Met Met Leu  Gly Ser Ser Thr Tyr  Lys Tyr Asn 
    1205                 1210                 1215             


Ala Lys  Gln Leu Val Leu Ser  Glu Lys Ala Leu Gln  Val Ile Ala 
    1220                 1225                 1230             


Asp Asp  Arg Lys Phe Asp Glu  Thr Gln Lys Asp Asp  Asn Leu Ile 
    1235                 1240                 1245             


Ala Val  Tyr Asp Glu Ile Leu  Ser Ile Val Asn Gln  Ser Phe Asp 
    1250                 1255                 1260             


Leu Tyr  Asp Ile Asn Gly Phe  Arg Lys Lys Leu Asn  Asp Asn Arg 
    1265                 1270                 1275             


Asp Gln  Phe Ile Asp Leu Pro  Ala Glu Thr Lys Tyr  Glu Gly Arg 
    1280                 1285                 1290             


Lys Val  Val Ala His Gly Lys  Arg Glu Met Ile Leu  Glu Ile Leu 
    1295                 1300                 1305             


Lys Gly  Leu His Ala Asn Ala  Ala Phe Gly Asn Leu  Lys Pro Ile 
    1310                 1315                 1320             


Gly Phe  Ser Thr Ala Phe Gly  Gln Leu Gln Val Pro  Asn Gly Ile 
    1325                 1330                 1335             


Ile Leu  Ser Lys Asn Ala Ile  Leu Ile His Gln Ser  Pro Ser Gly 
    1340                 1345                 1350             


Leu Phe  Glu Arg Lys Ile Lys  Leu Ser Asp Leu 
    1355                 1360                 


<210> 382
<211> 1366
<212> PRT
<213> Pediococcus acidilactici


<220>
<223> Pediococcus acidilactici MA18/5M

<400> 382
Met Gly Asp Arg Lys Tyr Asn Leu Gly Leu Asp Ile Gly Thr Ser Ser 
1               5                   10                  15      


Ile Gly Phe Ala Ala Val Asp Glu Asn Asn Gln Pro Ile Arg Val Lys 
            20                  25                  30          


Gly Lys Thr Ala Ile Gly Val Arg Leu Phe Glu Glu Gly Lys Thr Ala 
        35                  40                  45              


Ala Asp Arg Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg 
    50                  55                  60                  


Arg Trp Arg Ile Asn Leu Leu Asn Glu Ile Phe Asp Ala His Leu Ala 
65                  70                  75                  80  


Glu Val Asp Pro Thr Phe Leu Ala Arg Leu Lys Glu Ser Asn Arg Ser 
                85                  90                  95      


Asn Leu Asp Pro Lys Lys Ser Phe Gln Gly Ser Leu Leu Phe Pro Glu 
            100                 105                 110         


Arg Lys Asp Tyr Gln Phe Tyr Glu Glu Tyr Pro Thr Ile Tyr His Leu 
        115                 120                 125             


Arg Lys Ala Leu Met Glu Glu Asp Arg Lys Phe Asp Ile Arg Glu Ile 
    130                 135                 140                 


Tyr Leu Ala Val His His Ile Ile Lys Tyr Arg Gly Asn Phe Leu Asn 
145                 150                 155                 160 


Gly Thr Pro Met Arg Ser Phe Lys Val Glu Asn Ile Glu Leu Asp Thr 
                165                 170                 175     


Leu Phe Asp Gln Leu Asn Gln Leu Tyr Ala Glu Ile Val Pro Asp Asn 
            180                 185                 190         


Glu Leu Ala Phe Asp Leu Ala Gln Val Ala Asp Val Lys Asp Val Leu 
        195                 200                 205             


Ser Ser Thr Thr Ile Tyr Lys Met Asp Lys Lys Lys Gln Leu Val Lys 
    210                 215                 220                 


Met Met Leu Leu Pro Ala Ser Asn Lys Ala Leu Gln Ser Glu Asn Lys 
225                 230                 235                 240 


Lys Ile Val Thr Gln Phe Val Asn Ala Ile Leu Asn Tyr Lys Phe Lys 
                245                 250                 255     


Leu Asp Val Leu Leu Gln Val Glu Thr Asp Ala Asp Trp Ser Leu Lys 
            260                 265                 270         


Leu Asn Asp Glu Gly Ala Asp Asp Lys Leu Glu Glu Phe Thr Gly Asp 
        275                 280                 285             


Leu Asp Glu Asn Arg Leu Glu Ile Ile Asp Leu Leu Gln Arg Leu His 
    290                 295                 300                 


Asn Trp Phe Ser Leu Asn Glu Ile Thr Lys Asp Gly Asn Ser Leu Ser 
305                 310                 315                 320 


Ala Ala Met Val Glu Lys Tyr Glu Asn His His His His Leu Gly Leu 
                325                 330                 335     


Leu Lys Lys Val Ile Glu Asn His Pro Asp Ala Lys Lys Ala Lys Ala 
            340                 345                 350         


Leu Lys Glu Thr Tyr Thr Ala Tyr Val Gly Lys Thr Asp Asp Lys Thr 
        355                 360                 365             


Gln Asn Gln Asp Asp Phe Tyr Lys Ala Val Glu Lys Asn Leu Asp Asp 
    370                 375                 380                 


Ser Pro Asp Ala Lys Glu Ile Lys Arg Leu Ile Gln Leu Asp Gln Phe 
385                 390                 395                 400 


Met Pro Lys Gln Arg Thr Gly Gln Asn Gly Ala Ile Pro His Gln Leu 
                405                 410                 415     


His Gln Gln Glu Leu Asp Gln Ile Ile Glu Lys Gln Ser Lys Tyr Tyr 
            420                 425                 430         


Pro Phe Leu Ala Glu Pro Asn Pro Asn Val Lys Arg Arg Lys Asp Ala 
        435                 440                 445             


Pro Tyr Lys Leu Asp Glu Leu Ile Ala Phe Lys Ile Pro Tyr Tyr Val 
    450                 455                 460                 


Gly Pro Leu Val Thr Pro Glu Glu Gln Ala Gln Asn Lys Glu Asn Val 
465                 470                 475                 480 


Phe Ala Trp Met Lys Arg Lys Ala Ala Gly Pro Ile Thr Pro Trp Asn 
                485                 490                 495     


Phe Asp Glu Lys Val Asp Arg Met Glu Ser Ala Asn Arg Phe Ile Arg 
            500                 505                 510         


Arg Met Thr Thr Lys Asp Thr Tyr Leu Phe Gly Glu Asp Val Leu Pro 
        515                 520                 525             


Ala Glu Ser Met Ile Tyr Gln Lys Phe Val Val Leu Asn Glu Leu Asn 
    530                 535                 540                 


Asn Leu Lys Ile Asn Gly Arg His Leu Ser Leu Lys Asp Lys Gln Asp 
545                 550                 555                 560 


Val Tyr Asn Asp Leu Phe Lys Gln Gln Lys Thr Val Ser Ile Lys Ala 
                565                 570                 575     


Leu Gln Asn Tyr Tyr Val Thr Lys Lys Lys Ala Ala Thr Ala Pro Thr 
            580                 585                 590         


Val Gly Gly Leu Ala Asp Pro Lys Lys Phe Leu Ser Ser Leu Ser Thr 
        595                 600                 605             


Tyr Ile Asp Phe Lys Asn Met Phe Gly Glu Arg Val Asn Asp Pro Gln 
    610                 615                 620                 


Phe Gln Glu Asp Leu Glu Gln Ile Val Glu Trp Ser Thr Ile Phe Glu 
625                 630                 635                 640 


Asp Arg Gly Ile Phe Lys Ala Lys Leu Gln Ala Leu Gly Trp Leu Ser 
                645                 650                 655     


Glu Lys Gln Ile Gln Gln Leu Val Ala Lys Arg Tyr Lys Gly Trp Gly 
            660                 665                 670         


Arg Leu Ser Lys Lys Leu Leu Thr Gly Leu Lys Asn Ala Glu Gly Tyr 
        675                 680                 685             


Ser Ile Leu Asp Glu Met Trp Arg Ser Thr Glu Asn Phe Met Gln Ile 
    690                 695                 700                 


Gln Thr Arg Pro Glu Phe Ala Ala Leu Ile Gln Gln Ala Asn Glu Lys 
705                 710                 715                 720 


Gln Phe Glu Gly Asn Asp Pro Asn Asn Val Trp Glu Asn Ile Glu Ser 
                725                 730                 735     


Ile Leu Gly Asp Ala Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile Arg 
            740                 745                 750         


Gln Val Val Lys Val Val Gln Asp Ile Glu Lys Ala Val Gly Asn Pro 
        755                 760                 765             


Pro Glu Lys Ile Ala Ile Glu Phe Thr Arg Glu Ala Ala Ala Asn Pro 
    770                 775                 780                 


Gln Arg Thr Gln Ser Arg Leu Arg Thr Leu Glu Lys Leu Tyr Glu Ser 
785                 790                 795                 800 


Ala Glu Glu Val Val Asp Ala Gly Leu Thr Ala Glu Leu Ala Glu Phe 
                805                 810                 815     


Lys Glu Asn Lys His Val Leu Ser Asp Lys Tyr Tyr Leu Tyr Phe Thr 
            820                 825                 830         


Gln Leu Gly Arg Asp Val Tyr Thr Gly Asp Thr Ile Ser Leu Asp Lys 
        835                 840                 845             


Leu Asn Asp Tyr Asp Val Asp His Ile Leu Pro Gln Ser Phe Ile Lys 
    850                 855                 860                 


Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ile Arg Ala Val Asn Asn 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ala Lys Met Phe Gly Lys Lys Met Gly 
                885                 890                 895     


Ser Phe Trp Arg Tyr Leu Leu Asp Asn Gly Met Ile Ser Lys Arg Lys 
            900                 905                 910         


Tyr Asn Asn Leu Ile Thr Asp Pro Asp Asn Ile Ser Lys Tyr Ala Gln 
        915                 920                 925             


Lys Gly Phe Ile Asn Arg Gln Leu Val Glu Thr Ser Gln Val Ile Lys 
    930                 935                 940                 


Leu Thr Ala Asn Ile Leu Asn Gly Ile Tyr Asp Lys Asp Thr Glu Ile 
945                 950                 955                 960 


Ile Glu Val Pro Ala Lys Met Asn Ser Gln Met Arg Lys Met Phe Asp 
                965                 970                 975     


Leu Val Lys Val Arg Glu Val Asn Asp Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Tyr Leu Thr Ile Phe Ile Gly Lys  Tyr Leu Tyr Lys Cys  Tyr Pro Lys 
        995                 1000                 1005             


Leu Arg  Pro Tyr Phe Val Tyr  Gly Lys Phe Lys Lys  Phe Gly Asp 
    1010                 1015                 1020             


Asn Glu  Asp Ile Glu Val Gly  Asp Gly Arg Phe Asn  Phe Leu Asn 
    1025                 1030                 1035             


Arg Ile  Glu Arg Leu Lys Asn  Val Thr Asp Pro Glu  Thr Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Ser Asn Val Ala  Pro Asn Glu Thr Ile  Lys Gln Ile 
    1055                 1060                 1065             


Lys Lys  Val Tyr Asn Tyr Lys  Phe Met Leu Val Ser  Arg Glu Thr 
    1070                 1075                 1080             


Thr Thr  Arg Arg Ala Glu Leu  Phe Asn Gln Thr Val  Tyr Pro Lys 
    1085                 1090                 1095             


Asn Tyr  Arg Gly Lys Leu Ile  Pro Ile Lys Glu Asp  Arg Pro Thr 
    1100                 1105                 1110             


Asp Leu  Tyr Gly Gly Tyr Ser  Gly Asn Thr Asp Ala  Tyr Leu Ala 
    1115                 1120                 1125             


Ile Val  Ala Leu Glu Asp Lys  Lys Lys Gly Lys Tyr  Phe Lys Val 
    1130                 1135                 1140             


Val Gly  Ile Pro Thr Arg Ala  Ala Ala Lys Leu Glu  Lys Leu Lys 
    1145                 1150                 1155             


Gln Gln  Asp Ser Gln Gln Tyr  Leu Gln Ala Leu His  Lys Val Ile 
    1160                 1165                 1170             


Ala Pro  Gln Phe Thr Lys Ser  Thr Lys Lys Gly Ile  Lys Lys Thr 
    1175                 1180                 1185             


Glu Phe  Glu Ile Val Leu Asp  Lys Val His Tyr Arg  Gln Leu Val 
    1190                 1195                 1200             


Gln Asp  Gly Pro Val Lys Met  Met Leu Gly Ser Ser  Thr Tyr Lys 
    1205                 1210                 1215             


Tyr Asn  Ala Lys Gln Leu Val  Leu Ser Glu Lys Ala  Leu Gln Val 
    1220                 1225                 1230             


Ile Ala  Asp Asp Arg Lys Phe  Asp Glu Thr Gln Lys  Asp Asp Asn 
    1235                 1240                 1245             


Leu Ile  Ala Val Tyr Asp Glu  Ile Leu Ser Ile Val  Asn Gln Ser 
    1250                 1255                 1260             


Phe Asp  Leu Tyr Asp Ile Asn  Gly Phe Arg Lys Lys  Leu Asn Asp 
    1265                 1270                 1275             


Asn Arg  Asp Gln Phe Ile Asp  Leu Pro Ala Glu Thr  Lys Tyr Glu 
    1280                 1285                 1290             


Gly Arg  Lys Val Val Ala His  Gly Lys Arg Glu Met  Ile Leu Glu 
    1295                 1300                 1305             


Ile Leu  Lys Gly Leu His Ala  Asn Ala Ala Phe Gly  Asn Leu Lys 
    1310                 1315                 1320             


Pro Ile  Gly Phe Ser Thr Ala  Phe Gly Gln Leu Gln  Val Pro Asn 
    1325                 1330                 1335             


Gly Ile  Ile Leu Ser Lys Asn  Ala Ile Leu Ile His  Gln Ser Pro 
    1340                 1345                 1350             


Ser Gly  Leu Phe Glu Arg Lys  Ile Lys Leu Ser Asp  Leu 
    1355                 1360                 1365     


<210> 383
<211> 1364
<212> PRT
<213> Peptoniphilus duerdenii


<220>
<223> Peptoniphilus duerdenii ATCC BAA-1640

<400> 383
Met Lys Asn Leu Lys Glu Tyr Tyr Ile Gly Leu Asp Ile Gly Thr Ala 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Thr Asp Glu Ser Tyr Asn Ile Pro Lys Phe 
            20                  25                  30          


Asn Gly Lys Lys Met Trp Gly Val Arg Leu Phe Asp Asp Ala Lys Thr 
        35                  40                  45              


Ala Glu Glu Arg Arg Thr Gln Arg Gly Ser Arg Arg Arg Leu Asn Arg 
    50                  55                  60                  


Arg Lys Glu Arg Ile Asn Leu Leu Gln Asp Leu Phe Ala Thr Glu Ile 
65                  70                  75                  80  


Ser Lys Val Asp Pro Asn Phe Phe Leu Arg Leu Asp Asn Ser Asp Leu 
                85                  90                  95      


Tyr Arg Glu Asp Lys Asp Glu Lys Leu Lys Ser Lys Tyr Thr Leu Phe 
            100                 105                 110         


Asn Asp Lys Asp Phe Lys Asp Arg Asp Tyr His Lys Lys Tyr Pro Thr 
        115                 120                 125             


Ile His His Leu Ile Met Asp Leu Ile Glu Asp Glu Gly Lys Lys Asp 
    130                 135                 140                 


Ile Arg Leu Leu Tyr Leu Ala Cys His Tyr Leu Leu Lys Asn Arg Gly 
145                 150                 155                 160 


His Phe Ile Phe Glu Gly Gln Lys Phe Asp Thr Lys Asn Ser Phe Asp 
                165                 170                 175     


Lys Ser Ile Asn Asp Leu Lys Ile His Leu Arg Asp Glu Tyr Asn Ile 
            180                 185                 190         


Asp Leu Glu Phe Asn Asn Glu Asp Leu Ile Glu Ile Ile Thr Asp Thr 
        195                 200                 205             


Thr Leu Asn Lys Thr Asn Lys Lys Lys Glu Leu Lys Asn Ile Val Gly 
    210                 215                 220                 


Asp Thr Lys Phe Leu Lys Ala Ile Ser Ala Ile Met Ile Gly Ser Ser 
225                 230                 235                 240 


Gln Lys Leu Val Asp Leu Phe Glu Asp Gly Glu Phe Glu Glu Thr Thr 
                245                 250                 255     


Val Lys Ser Val Asp Phe Ser Thr Thr Ala Phe Asp Asp Lys Tyr Ser 
            260                 265                 270         


Glu Tyr Glu Glu Ala Leu Gly Asp Thr Ile Ser Leu Leu Asn Ile Leu 
        275                 280                 285             


Lys Ser Ile Tyr Asp Ser Ser Ile Leu Glu Asn Leu Leu Lys Asp Ala 
    290                 295                 300                 


Asp Lys Ser Lys Asp Gly Asn Lys Tyr Ile Ser Lys Ala Phe Val Lys 
305                 310                 315                 320 


Lys Phe Asn Lys His Gly Lys Asp Leu Lys Thr Leu Lys Arg Ile Ile 
                325                 330                 335     


Lys Lys Tyr Leu Pro Ser Glu Tyr Ala Asn Ile Phe Arg Asn Lys Ser 
            340                 345                 350         


Ile Asn Asp Asn Tyr Val Ala Tyr Thr Lys Ser Asn Ile Thr Ser Asn 
        355                 360                 365             


Lys Arg Thr Lys Ala Ser Lys Phe Thr Lys Gln Glu Asp Phe Tyr Lys 
    370                 375                 380                 


Phe Ile Lys Lys His Leu Asp Thr Ile Lys Glu Thr Lys Leu Asn Ser 
385                 390                 395                 400 


Ser Glu Asn Glu Asp Leu Lys Leu Ile Asp Glu Met Leu Thr Asp Ile 
                405                 410                 415     


Glu Phe Lys Thr Phe Ile Pro Lys Leu Lys Ser Ser Asp Asn Gly Val 
            420                 425                 430         


Ile Pro Tyr Gln Leu Lys Leu Met Glu Leu Lys Lys Ile Leu Asp Asn 
        435                 440                 445             


Gln Ser Lys Tyr Tyr Asp Phe Leu Asn Glu Ser Asp Glu Tyr Gly Thr 
    450                 455                 460                 


Val Lys Asp Lys Val Glu Ser Ile Met Glu Phe Arg Ile Pro Tyr Tyr 
465                 470                 475                 480 


Val Gly Pro Leu Asn Pro Asp Ser Lys Tyr Ala Trp Ile Lys Arg Glu 
                485                 490                 495     


Asn Thr Lys Ile Thr Pro Trp Asn Phe Lys Asp Ile Val Asp Leu Asp 
            500                 505                 510         


Ser Ser Arg Glu Glu Phe Ile Asp Arg Leu Ile Gly Arg Cys Thr Tyr 
        515                 520                 525             


Leu Lys Glu Glu Lys Val Leu Pro Lys Ala Ser Leu Ile Tyr Asn Glu 
    530                 535                 540                 


Phe Met Val Leu Asn Glu Leu Asn Asn Leu Lys Leu Asn Glu Phe Leu 
545                 550                 555                 560 


Ile Thr Glu Glu Met Lys Lys Ala Ile Phe Glu Glu Leu Phe Lys Thr 
                565                 570                 575     


Lys Lys Lys Val Thr Leu Lys Ala Val Ser Asn Leu Leu Lys Lys Glu 
            580                 585                 590         


Phe Asn Leu Thr Gly Asp Ile Leu Leu Ser Gly Thr Asp Gly Asp Phe 
        595                 600                 605             


Lys Gln Gly Leu Asn Ser Tyr Ile Asp Phe Lys Asn Ile Ile Gly Asp 
    610                 615                 620                 


Lys Val Asp Arg Asp Asp Tyr Arg Ile Lys Ile Glu Glu Ile Ile Lys 
625                 630                 635                 640 


Leu Ile Val Leu Tyr Glu Asp Asp Lys Thr Tyr Leu Lys Lys Lys Ile 
                645                 650                 655     


Lys Ser Ala Tyr Lys Asn Asp Phe Thr Asp Asp Glu Ile Lys Lys Ile 
            660                 665                 670         


Ala Ala Leu Asn Tyr Lys Asp Trp Gly Arg Leu Ser Lys Arg Phe Leu 
        675                 680                 685             


Thr Gly Ile Glu Gly Val Asp Lys Thr Thr Gly Glu Lys Gly Ser Ile 
    690                 695                 700                 


Ile Tyr Phe Met Arg Glu Tyr Asn Leu Asn Leu Met Glu Leu Met Ser 
705                 710                 715                 720 


Gly His Tyr Thr Phe Thr Glu Glu Val Glu Lys Leu Asn Pro Val Glu 
                725                 730                 735     


Asn Arg Glu Leu Cys Tyr Glu Met Val Asp Glu Leu Tyr Leu Ser Pro 
            740                 745                 750         


Ser Val Lys Arg Met Leu Trp Gln Ser Leu Arg Val Val Asp Glu Ile 
        755                 760                 765             


Lys Arg Ile Ile Gly Lys Asp Pro Lys Lys Ile Phe Ile Glu Met Ala 
    770                 775                 780                 


Arg Ala Lys Glu Ala Lys Asn Ser Arg Lys Glu Ser Arg Lys Asn Lys 
785                 790                 795                 800 


Leu Leu Glu Phe Tyr Lys Phe Gly Lys Lys Ala Phe Ile Asn Glu Ile 
                805                 810                 815     


Gly Glu Glu Arg Tyr Asn Tyr Leu Leu Asn Glu Ile Asn Ser Glu Glu 
            820                 825                 830         


Glu Ser Lys Phe Arg Trp Asp Asn Leu Tyr Leu Tyr Tyr Thr Gln Leu 
        835                 840                 845             


Gly Arg Cys Met Tyr Ser Leu Glu Pro Ile Asp Leu Ala Asp Leu Lys 
    850                 855                 860                 


Ser Asn Asn Ile Tyr Asp Gln Asp His Ile Tyr Pro Lys Ser Lys Ile 
865                 870                 875                 880 


Tyr Asp Asp Ser Leu Glu Asn Arg Val Leu Val Lys Lys Asn Leu Asn 
                885                 890                 895     


His Glu Lys Gly Asn Gln Tyr Pro Ile Pro Glu Lys Val Leu Asn Lys 
            900                 905                 910         


Asn Ala Tyr Gly Phe Trp Lys Ile Leu Phe Asp Lys Gly Leu Ile Gly 
        915                 920                 925             


Gln Lys Lys Tyr Thr Arg Leu Thr Arg Arg Thr Pro Phe Glu Glu Arg 
    930                 935                 940                 


Glu Leu Ala Glu Phe Ile Glu Arg Gln Ile Val Glu Thr Arg Gln Ala 
945                 950                 955                 960 


Thr Lys Glu Thr Ala Asn Leu Leu Lys Asn Ile Cys Gln Asp Ser Glu 
                965                 970                 975     


Ile Val Tyr Ser Lys Ala Glu Asn Ala Ser Arg Phe Arg Gln Glu Phe 
            980                 985                 990         


Asp Ile Ile Lys Cys Arg Thr Val  Asn Asp Leu His His  Met His Asp 
        995                 1000                 1005             


Ala Tyr  Leu Asn Ile Val Val  Gly Asn Val Tyr Asn  Thr Lys Phe 
    1010                 1015                 1020             


Thr Lys  Asn Pro Leu Asn Phe  Ile Lys Asp Lys Asp  Asn Val Arg 
    1025                 1030                 1035             


Ser Tyr  Asn Leu Glu Asn Met  Phe Lys Tyr Asp Val  Val Arg Gly 
    1040                 1045                 1050             


Ser Tyr  Thr Ala Trp Ile Ala  Asp Asp Ser Glu Gly  Asn Val Lys 
    1055                 1060                 1065             


Ala Ala  Thr Ile Lys Lys Val  Lys Arg Glu Leu Glu  Gly Lys Asn 
    1070                 1075                 1080             


Tyr Arg  Phe Thr Arg Met Ser  Tyr Ile Gly Thr Gly  Gly Leu Tyr 
    1085                 1090                 1095             


Asp Gln  Asn Leu Met Arg Lys  Gly Lys Gly Gln Ile  Pro Gln Lys 
    1100                 1105                 1110             


Glu Asn  Thr Asn Lys Ser Asn  Ile Glu Lys Tyr Gly  Gly Tyr Asn 
    1115                 1120                 1125             


Lys Ala  Ser Ser Ala Tyr Phe  Ala Leu Ile Glu Ser  Asp Gly Lys 
    1130                 1135                 1140             


Ala Gly  Arg Glu Arg Thr Leu  Glu Thr Ile Pro Ile  Met Val Tyr 
    1145                 1150                 1155             


Asn Gln  Glu Lys Tyr Gly Asn  Thr Glu Ala Val Asp  Lys Tyr Leu 
    1160                 1165                 1170             


Lys Asp  Asn Leu Glu Leu Gln  Asp Pro Lys Ile Leu  Lys Asp Lys 
    1175                 1180                 1185             


Ile Lys  Ile Asn Ser Leu Ile  Lys Leu Asp Gly Phe  Leu Tyr Asn 
    1190                 1195                 1200             


Ile Lys  Gly Lys Thr Gly Asp  Ser Leu Ser Ile Ala  Gly Ser Val 
    1205                 1210                 1215             


Gln Leu  Ile Val Asn Lys Glu  Glu Gln Lys Leu Ile  Lys Lys Met 
    1220                 1225                 1230             


Asp Lys  Phe Leu Val Lys Lys  Lys Asp Asn Lys Asp  Ile Lys Val 
    1235                 1240                 1245             


Thr Ser  Phe Asp Asn Ile Lys  Glu Glu Glu Leu Ile  Lys Leu Tyr 
    1250                 1255                 1260             


Lys Thr  Leu Ser Asp Lys Leu  Asn Asn Gly Ile Tyr  Ser Asn Lys 
    1265                 1270                 1275             


Arg Asn  Asn Gln Ala Lys Asn  Ile Ser Glu Ala Leu  Asp Lys Phe 
    1280                 1285                 1290             


Lys Glu  Ile Ser Ile Glu Glu  Lys Ile Asp Val Leu  Asn Gln Ile 
    1295                 1300                 1305             


Ile Leu  Leu Phe Gln Ser Tyr  Asn Asn Gly Cys Asn  Leu Lys Ser 
    1310                 1315                 1320             


Ile Gly  Leu Ser Ala Lys Thr  Gly Val Val Phe Ile  Pro Lys Lys 
    1325                 1330                 1335             


Leu Asn  Tyr Lys Glu Cys Lys  Leu Ile Asn Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Phe  Glu Asn Glu Val Asp  Leu Leu Asn Leu 
    1355                 1360                 


<210> 384
<211> 1087
<212> PRT
<213> Phascolarctobacterium succinatutens


<220>
<223> Phascolarctobacterium succinatutens YIT 12067

<400> 384
Met Leu Arg Met Lys Tyr Ala Ile Gly Leu Asp Ile Gly Ile Ala Ser 
1               5                   10                  15      


Val Gly Tyr Ala Val Leu Ala Leu Asp His Glu Glu Asn Pro Trp Gly 
            20                  25                  30          


Ile Ile Arg Leu Gly Ser Arg Ile Phe Asp Val Ala Glu Asn Pro Lys 
        35                  40                  45              


Asp Gly Ala Ser Leu Ala Leu Pro Arg Arg Glu Ala Arg Ser Val Arg 
    50                  55                  60                  


Arg Arg Leu Arg Arg His His His Arg Leu Glu Arg Ile Lys Asn Leu 
65                  70                  75                  80  


Leu Ile Asn Thr Glu Phe Ile Thr Lys Asp Glu Leu Leu His Leu Tyr 
                85                  90                  95      


Asp Gly Asn Leu Ser Asp Val Tyr Glu Leu Arg Val Lys Ala Leu Asp 
            100                 105                 110         


Tyr Ser Val Thr Asn Ala Glu Leu Thr Arg Ile Leu Leu His Leu Ala 
        115                 120                 125             


Gln Arg Arg Gly Phe Lys Ser Asn Arg Lys Ser Asp Ala Asn Asp Lys 
    130                 135                 140                 


Glu Ala Gly Gln Leu Leu Glu Ala Val Ser Ala Asn Ala Lys Arg Met 
145                 150                 155                 160 


Gln Glu Asn His Tyr Arg Thr Val Gly Glu Met Phe Tyr Lys Asp Asp 
                165                 170                 175     


Leu Phe Ser Lys Tyr Lys Arg Asn Lys Gly Gly Thr Tyr Leu Thr Thr 
            180                 185                 190         


Val His Arg Asp Met Ile Ala Ala Glu Ala Arg Thr Ile Leu Glu Lys 
        195                 200                 205             


Gln Phe Ala Leu Gly Asn Asn Ile Cys Thr Gln Asp Phe Ile Asp Lys 
    210                 215                 220                 


Tyr Leu Ser Ile Leu Leu Ser Gln Arg Gln Phe Asp Glu Gly Pro Gly 
225                 230                 235                 240 


Glu Pro Ser Pro Tyr Ala Gly Asn Gln Ile Ala Asn Met Ile Gly Lys 
                245                 250                 255     


Cys Thr Phe Glu Pro Asn Glu Tyr Arg Ala Ala Lys Ala Ser Tyr Ser 
            260                 265                 270         


Phe Glu Arg Phe Asn Leu Leu Gln Lys Val Asn His Leu Arg Leu Leu 
        275                 280                 285             


Leu Glu Gly Lys Ser Ile Ala Leu Asp Asn Glu Gln Arg Lys Lys Ile 
    290                 295                 300                 


Ile Ala Leu Ala His Asp Lys Ala Asp Leu Arg Tyr Ser His Ile Arg 
305                 310                 315                 320 


Lys Ala Leu Gly Leu Asp Glu Lys Val Leu Phe Asn Thr Ile Thr Tyr 
                325                 330                 335     


Asn Asp Asp Val Ser Val Ile Glu Lys Lys Thr Lys Phe Asn Phe Leu 
            340                 345                 350         


Gln Ala Tyr His Gln Ile Lys Lys Val Leu Ala Glu Asp Met Gln Lys 
        355                 360                 365             


Leu Thr Thr Glu Gln Leu Asp Asn Ile Gly Gln Ile Leu Ser Thr Tyr 
    370                 375                 380                 


Lys Ser Asp Asn Lys Arg Thr Glu Glu Leu Ser Ala Leu Gly Leu Glu 
385                 390                 395                 400 


Lys Lys Ile Ile Asp Ala Leu Leu Gly Ile Asn Gly Leu Ser Lys Phe 
                405                 410                 415     


Ala His Leu Ser Leu Lys Ala Leu Arg Lys Ile Asn Pro Tyr Leu Glu 
            420                 425                 430         


Glu Gly Lys Ile Tyr Asn Glu Ala Cys Thr Ala Ala Gly Tyr Asp Phe 
        435                 440                 445             


Lys Ala His Ala Asn Thr Gln Lys Thr Glu Leu Leu Pro Ala Tyr Lys 
    450                 455                 460                 


Glu Glu Met Asp Asp Ile Thr Ser Pro Val Ala Arg Arg Ala Ile Ala 
465                 470                 475                 480 


Gln Ser Ile Lys Val Ile Asn Ala Ile Ile Arg Glu Gln Lys Gly Ser 
                485                 490                 495     


Pro Leu Tyr Ile Asn Ile Glu Leu Ala Arg Glu Met Ala Lys Gly Phe 
            500                 505                 510         


Asp Glu Arg Thr Gln Ile Asp Lys Ala Asn Lys Glu Asn Gln Ala Lys 
        515                 520                 525             


Asn Glu Arg Ile Met Glu Arg Ile Arg Thr Glu Phe His Lys Ala Asn 
    530                 535                 540                 


Pro Thr Gly Met Asp Leu Ile Lys Leu Lys Leu Trp Glu Glu Gln Asp 
545                 550                 555                 560 


Gly Arg Ser Pro Tyr Ser Gln Lys Ala Ile Ser Ile Asn Arg Leu Phe 
                565                 570                 575     


Glu Pro Gly Tyr Val Asp Ile Asp His Ile Val Pro Tyr Ser Ile Ser 
            580                 585                 590         


Phe Asp Asp Ser Phe Lys Asn Lys Val Leu Val Phe Ser Asp Glu Asn 
        595                 600                 605             


Arg Asp Lys Gly Asn Arg Leu Pro Ile Ala Tyr Leu Gln Ser Lys Phe 
    610                 615                 620                 


Gly Ala Lys Ala Ala Glu Asn Phe Met Ile Trp Val Gln Ser Asn Ile 
625                 630                 635                 640 


Lys Asp Tyr Lys Lys Arg Gln Lys Leu Leu Lys Arg Glu Ile Thr Glu 
                645                 650                 655     


Glu Asp Ile Asn Lys Phe Lys Glu Arg Asn Leu Gln Asp Thr Lys Thr 
            660                 665                 670         


Ile Ser Arg Phe Leu Tyr Asn Tyr Ile Asn Asp Tyr Leu Leu Phe Ala 
        675                 680                 685             


Pro Ser Asp Thr Gly Lys Lys Lys Arg Val Thr Ala Val Asn Gly Thr 
    690                 695                 700                 


Ile Thr Ala Tyr Leu Arg Lys Arg Trp Gly Ile Asn Lys Ile Arg Ala 
705                 710                 715                 720 


Asn Gly Asp Lys His His Ala Val Asp Ala Val Val Ile Ala Cys Thr 
                725                 730                 735     


Thr Asp Lys Met Ile Lys Asp Leu Ser Ser Phe Ser Arg Tyr His Glu 
            740                 745                 750         


Leu Glu Tyr Thr His Thr Asp Thr Glu Ser Phe Leu Val Asn Ser Leu 
        755                 760                 765             


Thr Gly Glu Ile Leu Lys Arg Phe Pro Tyr Pro Trp Glu Asp Phe Arg 
    770                 775                 780                 


Pro Glu Leu Met Ala Arg Leu Ser Asp Asn Pro Ala Asp Ala Leu Arg 
785                 790                 795                 800 


Lys Leu Asn Leu Ile Phe Tyr His Gly Ile Asp Leu Ser Thr Ile Lys 
                805                 810                 815     


Pro Ile Phe Val Ser Arg Met Pro Arg His Lys Val Thr Gly Ala Ala 
            820                 825                 830         


His Lys Ala Thr Ile Lys Ser Ala Arg Cys Leu Asp Asn Gly Ile Val 
        835                 840                 845             


Ile Cys Lys Thr Ser Leu Gln Asn Leu Lys Leu Asp Lys Glu Gly Glu 
    850                 855                 860                 


Ile Ala Asn Tyr Tyr Ala Pro Glu Ser Asp Thr Ile Leu Tyr Asn Ala 
865                 870                 875                 880 


Leu Lys Glu Arg Leu Arg Ser Tyr Asp Asn Lys Pro Ala Lys Ala Phe 
                885                 890                 895     


Ala Glu Pro Phe Tyr Lys Pro Lys Ala Asp Gly Thr Pro Gly Pro Leu 
            900                 905                 910         


Val Lys Lys Val Lys Val Tyr Glu Lys Ser Thr Leu Asn Val Ala Val 
        915                 920                 925             


Gln Gln Asn Thr Ala Val Ala Asp Asn Asp Ser Met Val Arg Val Asp 
    930                 935                 940                 


Val Phe His Val Lys Gly Asn Gly Tyr Tyr Leu Val Pro Ile Tyr Ile 
945                 950                 955                 960 


Ala Asp Thr Leu Lys Lys Glu Leu Pro Asn Lys Ala Ile Val Ala Tyr 
                965                 970                 975     


Lys Pro Tyr Ala Asp Trp Pro Val Met Asp Asp Ser Asn Phe Ile Phe 
            980                 985                 990         


Ser Leu Tyr Pro Asn Asp Leu Ile  Lys Phe Glu His Lys  Asn Ser Val 
        995                 1000                 1005             


Lys Phe  Ala Lys Val Asn Lys  Glu Ser Thr Leu Asn  Asp Phe Tyr 
    1010                 1015                 1020             


Ser Thr  Lys Ser Glu Ile Val  Tyr Phe Lys Gly Cys  Asn Ile Asn 
    1025                 1030                 1035             


Thr Gly  Ala Ile Thr Ile Ile  Asn His Glu Asn Thr  Tyr Val Val 
    1040                 1045                 1050             


Ser Ser  Leu Gly Val Lys Thr  Leu Pro Ser Leu Glu  Lys Tyr Gln 
    1055                 1060                 1065             


Ala Asp  Val Leu Gly Asn Tyr  Thr Lys Val Lys Lys  Glu Val Arg 
    1070                 1075                 1080             


Lys Pro  Phe Arg 
    1085         


<210> 385
<211> 1333
<212> PRT
<213> Planococcus antarcticus


<220>
<223> Planococcus antarcticus DSM 14505

<400> 385
Met Lys Asn Tyr Thr Ile Gly Leu Asp Ile Gly Val Ala Ser Val Gly 
1               5                   10                  15      


Trp Val Cys Ile Asp Glu Asn Tyr Lys Ile Leu Asn Tyr Asn Asn Arg 
            20                  25                  30          


His Ala Phe Gly Val His Glu Phe Glu Ser Ala Glu Ser Ala Ala Gly 
        35                  40                  45              


Arg Arg Leu Lys Arg Gly Met Arg Arg Arg Tyr Asn Arg Arg Lys Lys 
    50                  55                  60                  


Arg Leu Gln Leu Leu Gln Ser Leu Phe Asp Ser Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gly Phe Phe Ser Lys Thr Asp Ser Gln His Phe Trp Lys Asn Asn Asn 
                85                  90                  95      


Glu Phe Glu Asn Arg Ser Leu Thr Glu Val Leu Ser Ser Leu Arg Ile 
            100                 105                 110         


Ser Ser Arg Lys Tyr Pro Thr Ile Tyr His Leu Arg Ser Asp Leu Ile 
        115                 120                 125             


Glu Ser Asn Lys Lys Met Asp Leu Arg Leu Val Tyr Leu Ala Leu His 
    130                 135                 140                 


Asn Leu Val Lys Tyr Arg Gly His Phe Leu Gln Glu Gly Asn Trp Ser 
145                 150                 155                 160 


Glu Ala Ala Ser Ala Glu Gly Met Asp Asp Gln Leu Leu Glu Leu Val 
                165                 170                 175     


Thr Arg Tyr Ala Glu Leu Glu Asn Leu Ser Pro Leu Asp Leu Ser Glu 
            180                 185                 190         


Ser Gln Trp Lys Ala Ala Glu Thr Leu Leu Leu Asn Arg Asn Leu Thr 
        195                 200                 205             


Lys Thr Asp Gln Ser Lys Glu Leu Thr Ala Met Phe Gly Lys Glu Tyr 
    210                 215                 220                 


Glu Pro Phe Cys Lys Leu Val Ala Gly Leu Gly Val Ser Leu His Gln 
225                 230                 235                 240 


Leu Phe Pro Ser Ser Glu Gln Ala Leu Ala Tyr Lys Glu Thr Lys Thr 
                245                 250                 255     


Lys Val Gln Leu Ser Asn Glu Asn Val Glu Glu Val Met Glu Leu Leu 
            260                 265                 270         


Leu Glu Glu Glu Ser Ala Leu Leu Glu Ala Val Gln Pro Phe Tyr Gln 
        275                 280                 285             


Gln Val Val Leu Tyr Glu Leu Leu Lys Gly Glu Thr Tyr Val Ala Lys 
    290                 295                 300                 


Ala Lys Val Ser Ala Phe Lys Gln Tyr Gln Lys Asp Met Ala Ser Leu 
305                 310                 315                 320 


Lys Asn Leu Leu Asp Lys Thr Phe Gly Glu Lys Val Tyr Arg Ser Tyr 
                325                 330                 335     


Phe Ile Ser Asp Lys Asn Ser Gln Arg Glu Tyr Gln Lys Ser His Lys 
            340                 345                 350         


Val Glu Val Leu Cys Lys Leu Asp Gln Phe Asn Lys Glu Ala Lys Phe 
        355                 360                 365             


Ala Glu Thr Phe Tyr Lys Asp Leu Lys Lys Leu Leu Glu Asp Lys Ser 
    370                 375                 380                 


Lys Thr Ser Ile Gly Thr Thr Glu Lys Asp Glu Met Leu Arg Ile Ile 
385                 390                 395                 400 


Lys Ala Ile Asp Ser Asn Gln Phe Leu Gln Lys Gln Lys Gly Ile Gln 
                405                 410                 415     


Asn Ala Ala Ile Pro His Gln Asn Ser Leu Tyr Glu Ala Glu Lys Ile 
            420                 425                 430         


Leu Arg Asn Gln Gln Ala His Tyr Pro Phe Ile Thr Thr Glu Trp Ile 
        435                 440                 445             


Glu Lys Val Lys Gln Ile Leu Ala Phe Arg Ile Pro Tyr Tyr Ile Gly 
    450                 455                 460                 


Pro Leu Val Lys Asp Thr Thr Gln Ser Pro Phe Ser Trp Val Glu Arg 
465                 470                 475                 480 


Lys Gly Asp Ala Pro Ile Thr Pro Trp Asn Phe Asp Glu Gln Ile Asp 
                485                 490                 495     


Lys Ala Ala Ser Ala Glu Ala Phe Ile Ser Arg Met Arg Lys Thr Cys 
            500                 505                 510         


Thr Tyr Leu Lys Gly Gln Glu Val Leu Pro Lys Ser Ser Leu Thr Tyr 
        515                 520                 525             


Glu Arg Phe Glu Val Leu Asn Glu Leu Asn Gly Ile Gln Leu Arg Thr 
    530                 535                 540                 


Thr Gly Ala Glu Ser Asp Phe Arg His Arg Leu Ser Tyr Glu Met Lys 
545                 550                 555                 560 


Cys Trp Ile Ile Asp Asn Val Phe Lys Gln Tyr Lys Thr Val Ser Thr 
                565                 570                 575     


Lys Arg Leu Leu Gln Glu Leu Lys Lys Ser Pro Tyr Ala Asp Glu Leu 
            580                 585                 590         


Tyr Asp Glu His Thr Gly Glu Ile Lys Glu Val Phe Gly Thr Gln Lys 
        595                 600                 605             


Glu Asn Ala Phe Ala Thr Ser Leu Ser Gly Tyr Ile Ser Met Lys Ser 
    610                 615                 620                 


Ile Leu Gly Ala Val Val Asp Asp Asn Pro Ala Met Thr Glu Glu Leu 
625                 630                 635                 640 


Ile Tyr Trp Ile Ala Val Phe Glu Asp Arg Glu Ile Leu His Leu Lys 
                645                 650                 655     


Ile Gln Glu Lys Tyr Pro Ser Ile Thr Asp Val Gln Arg Gln Lys Leu 
            660                 665                 670         


Ala Leu Val Lys Leu Pro Gly Trp Gly Arg Phe Ser Arg Leu Leu Ile 
        675                 680                 685             


Asp Gly Leu Pro Leu Asp Glu Gln Gly Gln Ser Val Leu Asp His Met 
    690                 695                 700                 


Glu Gln Tyr Ser Ser Val Phe Met Glu Val Leu Lys Asn Lys Gly Phe 
705                 710                 715                 720 


Gly Leu Glu Lys Lys Ile Gln Lys Met Asn Gln His Gln Val Asp Gly 
                725                 730                 735     


Thr Lys Lys Ile Arg Tyr Glu Asp Ile Glu Glu Leu Ala Gly Ser Pro 
            740                 745                 750         


Ala Leu Lys Arg Gly Ile Trp Arg Ser Val Lys Ile Val Glu Glu Leu 
        755                 760                 765             


Val Ser Ile Phe Gly Glu Pro Ala Asn Ile Val Leu Glu Val Ala Arg 
    770                 775                 780                 


Glu Asp Gly Glu Lys Lys Arg Thr Lys Ser Arg Lys Asp Gln Trp Glu 
785                 790                 795                 800 


Glu Leu Thr Lys Thr Thr Leu Lys Asn Asp Pro Asp Leu Lys Ser Phe 
                805                 810                 815     


Ile Gly Glu Ile Lys Ser Gln Gly Asp Gln Arg Phe Asn Glu Gln Arg 
            820                 825                 830         


Phe Trp Leu Tyr Val Thr Gln Gln Gly Lys Cys Leu Tyr Thr Gly Lys 
        835                 840                 845             


Ala Leu Asp Ile Gln Asn Leu Ser Met Tyr Glu Val Asp His Ile Leu 
    850                 855                 860                 


Pro Gln Asn Phe Val Lys Asp Asp Ser Leu Asp Asn Leu Ala Leu Val 
865                 870                 875                 880 


Met Pro Glu Ala Asn Gln Arg Lys Asn Gln Val Gly Gln Asn Lys Met 
                885                 890                 895     


Pro Leu Glu Ile Ile Glu Ala Asn Gln Gln Tyr Ala Met Arg Thr Leu 
            900                 905                 910         


Trp Glu Arg Leu His Glu Leu Lys Leu Ile Ser Ser Gly Lys Leu Gly 
        915                 920                 925             


Arg Leu Lys Lys Pro Ser Phe Asp Glu Val Asp Lys Asp Lys Phe Ile 
    930                 935                 940                 


Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Lys His Val Arg Asp 
945                 950                 955                 960 


Leu Leu Asp Glu Arg Phe Ser Lys Ser Asp Ile His Leu Val Lys Ala 
                965                 970                 975     


Gly Ile Val Ser Lys Phe Arg Arg Phe Ser Glu Ile Pro Lys Ile Arg 
            980                 985                 990         


Asp Tyr Asn Asn Lys His His Ala  Met Asp Ala Leu Phe  Ala Ala Ala 
        995                 1000                 1005             


Leu Ile  Gln Ser Ile Leu Gly  Lys Tyr Gly Lys Asn  Phe Leu Ala 
    1010                 1015                 1020             


Phe Asp  Leu Ser Lys Lys Asp  Arg Gln Lys Gln Trp  Arg Ser Val 
    1025                 1030                 1035             


Lys Gly  Ser Asn Lys Glu Phe  Phe Leu Phe Lys Asn  Phe Gly Asn 
    1040                 1045                 1050             


Leu Arg  Leu Gln Ser Pro Val  Thr Gly Glu Glu Val  Ser Gly Val 
    1055                 1060                 1065             


Glu Tyr  Met Lys His Val Tyr  Phe Glu Leu Pro Trp  Gln Thr Thr 
    1070                 1075                 1080             


Lys Met  Thr Gln Thr Gly Asp  Gly Met Phe Tyr Lys  Glu Ser Ile 
    1085                 1090                 1095             


Phe Ser  Pro Lys Val Lys Gln  Ala Lys Tyr Val Ser  Pro Lys Thr 
    1100                 1105                 1110             


Glu Lys  Phe Val His Asp Glu  Val Lys Asn His Ser  Ile Cys Leu 
    1115                 1120                 1125             


Val Glu  Phe Thr Phe Met Lys  Lys Glu Lys Glu Val  Gln Glu Thr 
    1130                 1135                 1140             


Lys Phe  Ile Asp Leu Lys Val  Ile Glu His His Gln  Phe Leu Lys 
    1145                 1150                 1155             


Glu Pro  Glu Ser Gln Leu Ala  Lys Phe Leu Ala Glu  Lys Glu Thr 
    1160                 1165                 1170             


Asn Ser  Pro Ile Ile His Ala  Arg Ile Ile Arg Thr  Ile Pro Lys 
    1175                 1180                 1185             


Tyr Gln  Lys Ile Trp Ile Glu  His Phe Pro Tyr Tyr  Phe Ile Ser 
    1190                 1195                 1200             


Thr Arg  Glu Leu His Asn Ala  Arg Gln Phe Glu Ile  Ser Tyr Glu 
    1205                 1210                 1215             


Leu Met  Glu Lys Val Lys Gln  Leu Ser Glu Arg Ser  Ser Val Glu 
    1220                 1225                 1230             


Glu Leu  Lys Ile Val Phe Gly  Leu Leu Ile Asp Gln  Met Asn Asp 
    1235                 1240                 1245             


Asn Tyr  Pro Ile Tyr Thr Lys  Ser Ser Ile Gln Asp  Arg Val Gln 
    1250                 1255                 1260             


Lys Phe  Val Asp Thr Gln Leu  Tyr Asp Phe Lys Ser  Phe Glu Ile 
    1265                 1270                 1275             


Gly Phe  Glu Glu Leu Lys Lys  Ala Val Ala Ala Asn  Ala Gln Arg 
    1280                 1285                 1290             


Ser Asp  Thr Phe Gly Ser Arg  Ile Ser Lys Lys Pro  Lys Pro Glu 
    1295                 1300                 1305             


Glu Val  Ala Ile Gly Tyr Glu  Ser Ile Thr Gly Leu  Lys Tyr Arg 
    1310                 1315                 1320             


Lys Pro  Arg Ser Val Val Gly  Thr Lys Arg 
    1325                 1330             


<210> 386
<211> 1197
<212> PRT
<213> Porphyromonas sp.


<220>
<223> Porphyromonas sp. oral taxon 279 str. F0450

<400> 386
Met Leu Met Ser Lys His Val Leu Gly Leu Asp Leu Gly Val Gly Ser 
1               5                   10                  15      


Ile Gly Trp Cys Leu Ile Ala Leu Asp Ala Gln Gly Asp Pro Ala Glu 
            20                  25                  30          


Ile Leu Gly Met Gly Ser Arg Val Val Pro Leu Asn Asn Ala Thr Lys 
        35                  40                  45              


Ala Ile Glu Ala Phe Asn Ala Gly Ala Ala Phe Thr Ala Ser Gln Glu 
    50                  55                  60                  


Arg Thr Ala Arg Arg Thr Met Arg Arg Gly Phe Ala Arg Tyr Gln Leu 
65                  70                  75                  80  


Arg Arg Tyr Arg Leu Arg Arg Glu Leu Glu Lys Val Gly Met Leu Pro 
                85                  90                  95      


Asp Ala Ala Leu Ile Gln Leu Pro Leu Leu Glu Leu Trp Glu Leu Arg 
            100                 105                 110         


Glu Arg Ala Ala Thr Ala Gly Arg Arg Leu Thr Leu Pro Glu Leu Gly 
        115                 120                 125             


Arg Val Leu Cys His Ile Asn Gln Lys Arg Gly Tyr Arg His Val Lys 
    130                 135                 140                 


Ser Asp Ala Ala Ala Ile Val Gly Asp Glu Gly Glu Lys Lys Lys Asp 
145                 150                 155                 160 


Ser Asn Ser Ala Tyr Leu Ala Gly Ile Arg Ala Asn Asp Glu Lys Leu 
                165                 170                 175     


Gln Ala Glu His Lys Thr Val Gly Gln Tyr Phe Ala Glu Gln Leu Arg 
            180                 185                 190         


Gln Asn Gln Ser Glu Ser Pro Thr Gly Gly Ile Ser Tyr Arg Ile Lys 
        195                 200                 205             


Asp Gln Ile Phe Ser Arg Gln Cys Tyr Ile Asp Glu Tyr Asp Gln Ile 
    210                 215                 220                 


Met Ala Val Gln Arg Val His Tyr Pro Asp Ile Leu Thr Asp Glu Phe 
225                 230                 235                 240 


Ile Arg Met Leu Arg Asp Glu Val Ile Phe Met Gln Arg Pro Leu Lys 
                245                 250                 255     


Ser Cys Lys His Leu Val Ser Leu Cys Glu Phe Glu Lys Gln Glu Arg 
            260                 265                 270         


Val Met Arg Val Gln Gln Asp Asp Gly Lys Gly Gly Trp Gln Leu Val 
        275                 280                 285             


Glu Arg Arg Val Lys Phe Gly Pro Lys Val Ala Pro Lys Ser Ser Pro 
    290                 295                 300                 


Leu Phe Gln Leu Cys Cys Ile Tyr Glu Ala Val Asn Asn Ile Arg Leu 
305                 310                 315                 320 


Thr Arg Pro Asn Gly Ser Pro Cys Asp Ile Thr Pro Glu Glu Arg Ala 
                325                 330                 335     


Lys Ile Val Ala His Leu Gln Ser Ser Ala Ser Leu Ser Phe Ala Ala 
            340                 345                 350         


Leu Lys Lys Leu Leu Lys Glu Lys Ala Leu Ile Ala Asp Gln Leu Thr 
        355                 360                 365             


Ser Lys Ser Gly Leu Lys Gly Asn Ser Thr Arg Val Ala Leu Ala Ser 
    370                 375                 380                 


Ala Leu Gln Pro Tyr Pro Gln Tyr His His Leu Leu Asp Met Glu Leu 
385                 390                 395                 400 


Glu Thr Arg Met Met Thr Val Gln Leu Thr Asp Glu Glu Thr Gly Glu 
                405                 410                 415     


Val Thr Glu Arg Glu Val Ala Val Val Thr Asp Ser Tyr Val Arg Lys 
            420                 425                 430         


Pro Leu Tyr Arg Leu Trp His Ile Leu Tyr Ser Ile Glu Glu Arg Glu 
        435                 440                 445             


Ala Met Arg Arg Ala Leu Ile Thr Gln Leu Gly Met Lys Glu Glu Asp 
    450                 455                 460                 


Leu Asp Gly Gly Leu Leu Asp Gln Leu Tyr Arg Leu Asp Phe Val Lys 
465                 470                 475                 480 


Pro Gly Tyr Gly Asn Lys Ser Ala Lys Phe Ile Cys Lys Leu Leu Pro 
                485                 490                 495     


Gln Leu Gln Gln Gly Leu Gly Tyr Ser Glu Ala Cys Ala Ala Val Gly 
            500                 505                 510         


Tyr Arg His Ser Asn Ser Pro Thr Ser Glu Glu Ile Thr Glu Arg Thr 
        515                 520                 525             


Leu Leu Glu Lys Ile Pro Leu Leu Gln Arg Asn Glu Leu Arg Gln Pro 
    530                 535                 540                 


Leu Val Glu Lys Ile Leu Asn Gln Met Ile Asn Leu Val Asn Ala Leu 
545                 550                 555                 560 


Lys Ala Glu Tyr Gly Ile Asp Glu Val Arg Val Glu Leu Ala Arg Glu 
                565                 570                 575     


Leu Lys Met Ser Arg Glu Glu Arg Glu Arg Met Ala Arg Asn Asn Lys 
            580                 585                 590         


Asp Arg Glu Glu Arg Asn Lys Gly Val Ala Ala Lys Ile Arg Glu Cys 
        595                 600                 605             


Gly Leu Tyr Pro Thr Lys Pro Arg Ile Gln Lys Tyr Met Leu Trp Lys 
    610                 615                 620                 


Glu Ala Gly Arg Gln Cys Leu Tyr Cys Gly Arg Ser Ile Glu Glu Glu 
625                 630                 635                 640 


Gln Cys Leu Arg Glu Gly Gly Met Glu Val Glu His Ile Ile Pro Lys 
                645                 650                 655     


Ser Val Leu Tyr Asp Asp Ser Tyr Gly Asn Lys Thr Cys Ala Cys Arg 
            660                 665                 670         


Arg Cys Asn Lys Glu Lys Gly Asn Arg Thr Ala Leu Glu Tyr Ile Arg 
        675                 680                 685             


Ala Lys Gly Arg Glu Ala Glu Tyr Met Lys Arg Ile Asn Asp Leu Leu 
    690                 695                 700                 


Lys Glu Lys Lys Ile Ser Tyr Ser Lys His Gln Arg Leu Arg Trp Leu 
705                 710                 715                 720 


Lys Glu Asp Ile Pro Ser Asp Phe Leu Glu Arg Gln Leu Arg Leu Thr 
                725                 730                 735     


Gln Tyr Ile Ser Arg Gln Ala Met Ala Ile Leu Gln Gln Gly Ile Arg 
            740                 745                 750         


Arg Val Ser Ala Ser Glu Gly Gly Val Thr Ala Arg Leu Arg Ser Leu 
        755                 760                 765             


Trp Gly Tyr Gly Lys Ile Leu His Thr Leu Asn Leu Asp Arg Tyr Asp 
    770                 775                 780                 


Ser Met Gly Glu Thr Glu Arg Val Ser Arg Glu Gly Glu Ala Thr Glu 
785                 790                 795                 800 


Glu Leu His Ile Thr Asn Trp Ser Lys Arg Met Asp His Arg His His 
                805                 810                 815     


Ala Ile Asp Ala Leu Val Val Ala Cys Thr Arg Gln Ser Tyr Ile Gln 
            820                 825                 830         


Arg Leu Asn Arg Leu Ser Ser Glu Phe Gly Arg Glu Asp Lys Lys Lys 
        835                 840                 845             


Glu Asp Gln Glu Ala Gln Glu Gln Gln Ala Thr Glu Thr Gly Arg Leu 
    850                 855                 860                 


Ser Asn Leu Glu Arg Trp Leu Thr Gln Arg Pro His Phe Ser Val Arg 
865                 870                 875                 880 


Thr Val Ser Asp Lys Val Ala Glu Ile Leu Ile Ser Tyr Arg Pro Gly 
                885                 890                 895     


Gln Arg Val Val Thr Arg Gly Arg Asn Ile Tyr Arg Lys Lys Met Ala 
            900                 905                 910         


Asp Gly Arg Glu Val Ser Cys Val Gln Arg Gly Val Leu Val Pro Arg 
        915                 920                 925             


Gly Glu Leu Met Glu Ala Ser Phe Tyr Gly Lys Ile Leu Ser Gln Gly 
    930                 935                 940                 


Arg Val Arg Ile Val Lys Arg Tyr Pro Leu His Asp Leu Lys Gly Glu 
945                 950                 955                 960 


Val Val Asp Pro His Leu Arg Glu Leu Ile Thr Thr Tyr Asn Gln Glu 
                965                 970                 975     


Leu Lys Ser Arg Glu Lys Gly Ala Pro Ile Pro Pro Leu Cys Leu Asp 
            980                 985                 990         


Lys Asp Lys Lys Gln Glu Val Arg  Ser Val Arg Cys Tyr  Ala Lys Thr 
        995                 1000                 1005             


Leu Ser  Leu Asp Lys Ala Ile  Pro Met Cys Phe Asp  Glu Lys Gly 
    1010                 1015                 1020             


Glu Pro  Thr Ala Phe Val Lys  Ser Ala Ser Asn His  His Leu Ala 
    1025                 1030                 1035             


Leu Tyr  Arg Thr Pro Lys Gly  Lys Leu Val Glu Ser  Ile Val Thr 
    1040                 1045                 1050             


Phe Trp  Asp Ala Val Asp Arg  Ala Arg Tyr Gly Ile  Pro Leu Val 
    1055                 1060                 1065             


Ile Thr  His Pro Arg Glu Val  Met Glu Gln Val Leu  Gln Arg Gly 
    1070                 1075                 1080             


Asp Ile  Pro Glu Gln Val Leu  Ser Leu Leu Pro Pro  Ser Asp Trp 
    1085                 1090                 1095             


Val Phe  Val Asp Ser Leu Gln  Gln Asp Glu Met Val  Val Ile Gly 
    1100                 1105                 1110             


Leu Ser  Asp Glu Glu Leu Gln  Arg Ala Leu Glu Ala  Gln Asn Tyr 
    1115                 1120                 1125             


Arg Lys  Ile Ser Glu His Leu  Tyr Arg Val Gln Lys  Met Ser Ser 
    1130                 1135                 1140             


Ser Tyr  Tyr Val Phe Arg Tyr  His Leu Glu Thr Ser  Val Ala Asp 
    1145                 1150                 1155             


Asp Lys  Asn Thr Ser Gly Arg  Ile Pro Lys Phe His  Arg Val Gln 
    1160                 1165                 1170             


Ser Leu  Lys Ala Tyr Glu Glu  Arg Asn Ile Arg Lys  Val Arg Val 
    1175                 1180                 1185             


Asp Leu  Leu Gly Arg Ile Ser  Leu Leu 
    1190                 1195         


<210> 387
<211> 1485
<212> PRT
<213> Prevotella bivia


<220>
<223> Prevotella bivia JCVIHMP010

<400> 387
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Lys Ile Ser Ile Asp Asp Asn Gly Lys Tyr Ile Lys Asp Ser Ile 
            20                  25                  30          


Lys Leu Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Val Leu Ser Asn 
        35                  40                  45              


Phe Ser Lys Gly Val Thr Leu Ser Gln Thr Ser Glu Arg Thr Ser Phe 
    50                  55                  60                  


Arg Gly Ala Arg Arg Leu Arg Glu Arg Thr Leu Leu Arg Arg Glu Arg 
65                  70                  75                  80  


Leu His Arg Ile Leu His Leu Leu Gly Phe Leu Pro Lys His Tyr Glu 
                85                  90                  95      


Lys Ala Ile Gly Trp Asp Arg Asn Asp Asn Lys Thr Tyr Gly Lys Phe 
            100                 105                 110         


Ile Asn His Ala Glu Pro Lys Leu Ala Trp Cys Lys Asp Asn Asn Gly 
        115                 120                 125             


Lys Met Arg Phe Leu Phe Met Asp Ser Phe His Asp Met Leu Ser Glu 
    130                 135                 140                 


Phe Ser Glu Lys His Pro Glu Leu Leu Ala Asn Gly Lys Lys Ile Pro 
145                 150                 155                 160 


Leu Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Tyr Lys Ala 
                165                 170                 175     


Ile Thr Lys Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys 
            180                 185                 190         


Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Asp Arg Asp Ser Glu Ala 
        195                 200                 205             


Asn Lys Lys Glu Tyr Leu Glu Leu Lys Val Ile Gly Val Glu Ala Thr 
    210                 215                 220                 


Gly Glu Lys Lys Gly Asn Asp Ile Trp Tyr Asn Ile His Leu Glu Asn 
225                 230                 235                 240 


Gly Trp Ile Tyr Arg Arg Ser Ser Lys Asn Pro Leu Asn Asp Trp Leu 
                245                 250                 255     


Gly Lys Val Lys Ser Phe Ile Val Thr Thr Asp Leu Asp Ala Asp Gly 
            260                 265                 270         


Asn Pro Lys Lys Asp Lys Asp Gly Asn Ile Lys Arg Ser Phe Arg Ala 
        275                 280                 285             


Pro Ser Glu Gly Asp Trp Thr Leu Ile Lys Lys Arg Thr Glu Ser Leu 
    290                 295                 300                 


Leu Glu Asn Ser Gly Gln Thr Val Gly Gln Phe Ile Tyr Asn His Ile 
305                 310                 315                 320 


Leu Glu Glu Pro Ser Ala Lys Ile Arg Gly Asn Phe Ile Arg Thr Ile 
                325                 330                 335     


Glu Arg Lys Tyr Tyr Lys Asp Glu Leu Lys Ala Ile Leu Glu Lys Gln 
            340                 345                 350         


Lys Glu Phe His His Glu Leu Ser Ser Glu Ser Leu Leu Thr Glu Cys 
        355                 360                 365             


Ala Lys Glu Leu Tyr Lys Arg Asn Ile Ala His Gln Glu Val Leu Leu 
    370                 375                 380                 


Lys Lys Gly Ile Ile His Leu Leu Leu Asn Asp Ile Leu Phe Tyr Gln 
385                 390                 395                 400 


Arg Pro Leu Lys Ile Lys Lys Ser Leu Ile Asp Asn Cys Pro Tyr Glu 
                405                 410                 415     


Asn Tyr Lys Tyr Val Asp Lys Lys Ser Gly Asp Ile Lys Val Lys Ser 
            420                 425                 430         


Ile Lys Cys Ile Ala Lys Ser Asn Pro Phe Phe Gln Glu Phe Arg Leu 
        435                 440                 445             


Trp Gln Phe Val Ser Asn Leu Arg Leu Tyr Arg Lys Ser Asp Asp Lys 
    450                 455                 460                 


Asp Val Thr Ser Glu His Leu Val Thr Thr Asp Asp Tyr Ala Asn Leu 
465                 470                 475                 480 


Phe Thr Tyr Leu Asn Asn Arg Lys Asp Ile Lys Gln Ser Val Leu Leu 
                485                 490                 495     


Lys Glu Tyr Phe Lys Ile Lys Lys Val Lys Thr Ile Asn Gly Ala Glu 
            500                 505                 510         


Tyr Pro Val Arg Trp Asn Tyr Ile Asp Asp Asp Asn Lys Thr Tyr Pro 
        515                 520                 525             


Cys Asn Glu Thr Arg Tyr Asp Ile Leu His Ala Leu Ser Lys Thr Glu 
    530                 535                 540                 


Leu Lys Ser Glu Trp Leu Thr Pro Glu Arg Thr Tyr Arg Leu Trp His 
545                 550                 555                 560 


Leu Leu Tyr Ser Ile Glu Ser Lys Glu Glu Thr Lys Lys Ala Leu Asn 
                565                 570                 575     


Lys Leu Asn Leu Ser Asp Asp Phe Thr Glu Ala Phe Leu Thr Ile Lys 
            580                 585                 590         


Pro Phe Lys Lys Glu Tyr Gly Ser Tyr Ser Glu Lys Ala Ile Lys Lys 
        595                 600                 605             


Leu Leu Ser Leu Met Arg Met Gly Tyr Leu Trp Ser Glu Asp Glu Ala 
    610                 615                 620                 


Ile Lys Gln Val Gly Ala Glu Ile Glu Lys Thr Ile Glu Gly Glu Leu 
625                 630                 635                 640 


Pro Asp Tyr Val Leu Gln Arg Leu Glu Lys Ser Gln His Asn Tyr Asn 
                645                 650                 655     


Lys Ile Ser Asp Phe Ser Gly Leu Pro Leu Trp Leu Ala Ser Tyr Ile 
            660                 665                 670         


Ile Tyr Gly Arg His Ser Glu Ala Lys Glu Ile Ile His Trp Asp Asn 
        675                 680                 685             


Pro Glu Ser Met Met Ala Tyr Ile Lys Asp Phe Arg Gln His Ser Met 
    690                 695                 700                 


Arg Asn Pro Ile Val Glu Gln Cys Val Leu Glu Thr Leu Arg Thr Val 
705                 710                 715                 720 


His Asp Ile Trp Lys Glu Ile Gly His Ile Asp Glu Ile His Ile Glu 
                725                 730                 735     


Leu Gly Arg Glu Met Lys Ser Thr Ser Glu Gln Arg Lys Ala Ile Thr 
            740                 745                 750         


Gln Asn Val Leu His Asn Gln Asn Thr Asn Ile Arg Ile Lys Leu Leu 
        755                 760                 765             


Leu Gln Glu Leu Lys Asn Asp Asn Asn Ile Thr Gly Val Arg Pro Tyr 
    770                 775                 780                 


Ser Pro Met Gln Gln Glu Ile Leu Arg Ile Tyr Glu Glu Gly Ala Leu 
785                 790                 795                 800 


Gln Gly Leu Thr Lys Glu Asp Lys Asp Tyr Asn Asp Ile Leu Lys Ile 
                805                 810                 815     


Ser Gln Thr Ala Gln Pro Thr Ser Asn Glu Leu Thr Arg Tyr Lys Leu 
            820                 825                 830         


Trp Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Lys Ala Ile Ser 
        835                 840                 845             


Leu Ser Lys Leu Phe Thr Ser Ala Tyr Gln Ile Glu His Val Ile Pro 
    850                 855                 860                 


Gln Ser Arg Tyr Phe Asp Asp Ser Leu Ser Asn Lys Val Ile Cys Glu 
865                 870                 875                 880 


Ser Glu Val Asn Thr Leu Lys Lys Ala Met Leu Gly Met Glu Phe Ile 
                885                 890                 895     


Lys Thr Cys Gly Gly Gln Lys Val His Cys Thr Leu Leu Gly Asp Val 
            900                 905                 910         


Glu Ile Tyr Asn Glu Glu Asp Tyr Lys Ala Phe Val Asn Glu His Tyr 
        915                 920                 925             


Ser Asn Asn Arg Thr Lys Arg Asn Lys Leu Leu Met Glu Asp Ile Pro 
    930                 935                 940                 


Gln Glu Phe Ile Asn Arg Gln Leu Asn Asp Ser Arg Tyr Ile Ser Lys 
945                 950                 955                 960 


Met Val Lys Gln Leu Leu Ser Ala Ile Val Arg Gly Gln Glu Glu Val 
                965                 970                 975     


Glu Ala Thr Ser Lys Phe Val Ile Pro Cys Thr Gly Gly Ile Thr Asp 
            980                 985                 990         


Arg Leu Lys Lys Asp Trp Gly Leu  Asn Asp Ile Trp Asn  Asn Leu Val 
        995                 1000                 1005             


Ser Pro  Arg Phe Gln Arg Met  Asn Ala Leu Thr Gly  Ser Glu Tyr 
    1010                 1015                 1020             


Phe Gly  His Trp Glu Asn Lys  Glu Gly Lys Arg Val  Phe Gln Thr 
    1025                 1030                 1035             


Thr Met  Pro Ile Gln Leu Gln  Gln Gly Phe Ser Lys  Lys Arg Ile 
    1040                 1045                 1050             


Asp His  Arg His His Ala Met  Asp Ala Leu Val Ile  Ala Cys Ala 
    1055                 1060                 1065             


Ser Arg  Asn Ile Ile Ser Tyr  Leu Asn Asn Glu Thr  Ala Gln Asp 
    1070                 1075                 1080             


Thr Glu  Arg Arg Arg Asp Leu  Arg Gln Lys Leu Cys  Asp Lys Gly 
    1085                 1090                 1095             


Gly Ser  Val Arg Lys Pro Trp  Asp Ser Phe Thr Gln  Asp Thr Gln 
    1100                 1105                 1110             


Tyr Ala  Leu Lys Asp Ile Ile  Val Thr Phe Lys Asn  Tyr Val Arg 
    1115                 1120                 1125             


Ile Ile  Asn Lys Ala Thr Asn  Tyr Tyr Glu His Tyr  Lys Thr Asp 
    1130                 1135                 1140             


Gly Lys  Lys Gly Met Ile Ser  Gln Lys Gly Asp Glu  Leu Trp Ala 
    1145                 1150                 1155             


Ile Arg  Lys Pro Met His Lys  Glu Thr Val Phe Gly  Lys Val Asn 
    1160                 1165                 1170             


Leu Arg  Arg Pro Lys Arg Val  Ser Leu Ser Lys Ala  Ile Asp Ser 
    1175                 1180                 1185             


Val Asp  Ile Ile Cys Asn Arg  Lys Leu Lys Lys Tyr  Ile Lys Ala 
    1190                 1195                 1200             


Arg Leu  Asn Glu Gly Leu Gln  Lys Lys Gln Ile Leu  Asn Ile Phe 
    1205                 1210                 1215             


Lys Glu  Leu Asn Asn Val Trp  Glu Gly Ile Asp Val  Asn Lys Ile 
    1220                 1225                 1230             


Asp Ile  Trp Glu Met Ser Asn  Asp Lys Glu Pro Met  Val Ala Thr 
    1235                 1240                 1245             


Arg Lys  Gln Leu Asp Thr Ser  Phe Asp Glu Lys Lys  Ile Arg Ser 
    1250                 1255                 1260             


Ile Ser  Asp Thr Gly Ile Gln  Lys Ile Leu Leu Asn  Tyr Leu Ile 
    1265                 1270                 1275             


Thr Lys  Asn Asn Asn Pro Glu  Leu Ala Phe Thr Pro  Glu Gly Ile 
    1280                 1285                 1290             


Gln Glu  Met Asn Ser Asn Ile  Ser Glu Tyr Asn Asp  His Lys Lys 
    1295                 1300                 1305             


His Gln  Pro Ile Tyr Lys Val  Arg Val Thr Glu Pro  Leu Gly Ala 
    1310                 1315                 1320             


Lys Tyr  Pro Ile Gly Thr Met  Gly Asn Asn Pro Lys  Lys Phe Val 
    1325                 1330                 1335             


Glu Ala  Gln Ala Gly Thr Asn  Leu Tyr Phe Ala Ile  Tyr Glu Asp 
    1340                 1345                 1350             


Lys Glu  Gly Lys Arg Asn Tyr  Asp Thr Ile Pro Leu  Asn Ile Ala 
    1355                 1360                 1365             


Ala Glu  Arg Leu Asn Gln Gln  Leu Ser Pro Val Pro  Glu Thr Asn 
    1370                 1375                 1380             


Glu Asn  Asn Thr Pro Leu Lys  Phe Tyr Leu Ser Pro  Asn Asp Leu 
    1385                 1390                 1395             


Val Tyr  Val Pro Ser Glu Glu  Glu Arg His Ser Gly  Asn Asn Ile 
    1400                 1405                 1410             


Gln Leu  Asp Lys Asn Arg Ile  Tyr Lys Met Val Ser  Ser Thr Ser 
    1415                 1420                 1425             


Lys Arg  Cys Phe Phe Ile His  His Arg Val Ala Ile  Ser Leu Val 
    1430                 1435                 1440             


Asp Lys  Lys Glu Phe Ser Ala  Gln Asn Lys Met Glu  Arg Ser Ile 
    1445                 1450                 1455             


Asp Asn  Glu Gln Val Met Ile  Lys Ser Val Cys Trp  Lys Leu Ile 
    1460                 1465                 1470             


Thr Asp  Arg Leu Gly Asn Ile  Ile Lys Val Ile Lys  
    1475                 1480                 1485 


<210> 388
<211> 1457
<212> PRT
<213> Prevotella buccae


<220>
<223> Prevotella buccae ATCC 33574

<400> 388
Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Lys Val Ser Val Asp Asp Tyr Gly Asn Tyr Leu His Asp Ile Lys 
            20                  25                  30          


Leu Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Val Leu Gly Asn Phe 
        35                  40                  45              


Asp Ser Gly Val Thr Val Ser Gln Thr Ala Gln Arg Thr Glu Phe Arg 
    50                  55                  60                  


Ser Lys Arg Arg Leu Val Gln Arg Asn Leu Gln Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu His Val Leu Asp Phe Leu Pro Ala His Tyr Asp Ala 
                85                  90                  95      


Ala Ile Gly Trp Asp Arg Thr Glu Ala Val Thr Tyr Gly Lys Phe Leu 
            100                 105                 110         


Asn His Ala Glu Pro Lys Leu Ala Trp Glu Glu Leu Gly Asn Gly Lys 
        115                 120                 125             


Arg Arg Phe Leu Phe Met Asp Ser Phe His Glu Met Val Ala Asp Phe 
    130                 135                 140                 


Ala Arg Cys Gln Pro Ala Leu Val Ala Asp Gly Lys Lys Ile Pro Leu 
145                 150                 155                 160 


Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Gln Ala Ile 
                165                 170                 175     


Thr Lys Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg 
            180                 185                 190         


Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Glu Glu Glu Asn Pro Thr Lys 
        195                 200                 205             


Gln Glu Glu Tyr Tyr Glu Leu Lys Val Val Ser Val Glu Ala Thr Asp 
    210                 215                 220                 


Ser Arg Lys Gly Asn Asp Thr Trp Tyr Asn Val His Leu Glu Asn Gly 
225                 230                 235                 240 


Trp Ile Tyr Arg Arg Ser Ser Lys Ile Ser Leu Asp Asp Trp Val Gly 
                245                 250                 255     


Lys Val Lys Gln Phe Ile Val Thr Thr Glu Tyr Glu Lys Asp Gly Ala 
            260                 265                 270         


Thr Leu Lys Thr Asp Lys Glu Gly Tyr Val Lys Arg Ser Phe Arg Ala 
        275                 280                 285             


Pro Asn Glu Asn Asp Trp Gly Leu Arg Lys Lys Arg Thr Glu Thr Leu 
    290                 295                 300                 


Leu Glu Met Ser Gly Lys Thr Val Gly Ala Phe Ile Tyr Asp His Leu 
305                 310                 315                 320 


Leu Gln Glu Pro Ala Asp Lys Ile Arg Gly Asn Phe Ile Arg Thr Ile 
                325                 330                 335     


Glu Arg His Tyr Tyr Lys Ala Glu Leu Glu Ala Ile Leu Ala Glu Gln 
            340                 345                 350         


Cys Lys Tyr His Ile Glu Leu Arg Asp Lys Glu Met Leu Glu Ala Cys 
        355                 360                 365             


Ala Arg Glu Leu Tyr Leu Asn Asn Leu Pro His Gln Arg Ser Leu Met 
    370                 375                 380                 


Lys Lys Asp Met Thr Tyr Leu Leu Leu Tyr Asp Leu Ile Phe Tyr Gln 
385                 390                 395                 400 


Arg Pro Leu Lys Ser Lys Lys Ala Leu Ile Ala Asn Cys Pro Tyr Glu 
                405                 410                 415     


Tyr Tyr Glu Tyr Val Asp Lys Glu Thr Gly Glu Ile Lys Arg Gln Asn 
            420                 425                 430         


Ile Lys Cys Ile Ala Lys Ser Asn Pro Tyr Phe Gln Glu Phe Arg Leu 
        435                 440                 445             


Trp Gln Phe Val Leu Asn Leu Arg Leu Phe Asp Arg Val Glu Asp Lys 
    450                 455                 460                 


Glu Val Thr Ala Asn Tyr Leu Pro Thr Ala Asp Asp His Ala Arg Leu 
465                 470                 475                 480 


Phe Thr Tyr Leu Asn Asp Arg Lys Glu Ile Asn Gln Glu Thr Leu Leu 
                485                 490                 495     


Lys Asp Tyr Phe Lys Leu Lys Lys Val Lys Ile Gly Asn Glu Lys Glu 
            500                 505                 510         


Tyr Pro Ile Arg Trp Asn Tyr Ile Glu Asp Lys Glu Lys Lys Tyr Pro 
        515                 520                 525             


Cys Asn Glu Thr Arg Tyr Glu Leu Leu Met Ala Leu Asp Arg Ala Gly 
    530                 535                 540                 


Ile Glu His Lys Trp Leu Asp Asp Asn Asn Leu Glu Tyr Arg Leu Trp 
545                 550                 555                 560 


His Leu Leu Tyr Ser Val Glu Val Lys Ser Glu Ser Glu Thr Ala Leu 
                565                 570                 575     


Arg Lys Leu Lys Asn Asp Asp Ala Phe Val Asn Ser Phe Leu Lys Val 
            580                 585                 590         


Lys Pro Phe Lys Lys Glu Tyr Gly Ala Tyr Ser Glu Lys Ala Ile Lys 
        595                 600                 605             


Arg Leu Leu Ala Val Met Arg Lys Gly Phe Leu Trp Asn Glu Gln Asp 
    610                 615                 620                 


Ile Cys Asp Glu Thr Arg Lys Arg Ile Glu Ile Ile Ile Lys Gly Asp 
625                 630                 635                 640 


Val Asp Glu Lys Val Lys Glu Arg Met Gly His Ala Ala Tyr Ser Phe 
                645                 650                 655     


Asp Arg Val Ser Asp Phe Gln Gly Leu Pro Glu Trp Leu Ala Cys Tyr 
            660                 665                 670         


Val Val Tyr Gly Arg His Ser Glu Ala Met Asp Ile Gln His Trp Asp 
        675                 680                 685             


Ser Pro Glu Arg Leu Met Ala Tyr Ile Asn Asn Phe Lys Gln Tyr Ser 
    690                 695                 700                 


Leu Arg Asn Pro Ile Val Glu Gln Cys Ile Leu Glu Thr Leu Arg Thr 
705                 710                 715                 720 


Val His Asp Ile Trp Lys Glu Thr Gly Gln Ile Asp Glu Ile His Val 
                725                 730                 735     


Glu Leu Gly Arg Glu Met Lys Ser Thr Ser Glu Glu Arg Ala Arg Arg 
            740                 745                 750         


Thr Gln Asn Val Leu Arg Asn Glu Asn Thr Asn Leu Arg Ile Lys Ser 
        755                 760                 765             


Leu Leu Ile Glu Leu Lys Asn Asp Thr Asp Ile Cys Asn Val His Pro 
    770                 775                 780                 


Tyr Ser Pro Met Gln Gln Glu Ile Leu Arg Ile Tyr Glu Glu Gly Ala 
785                 790                 795                 800 


Leu Gln Glu Leu Asn Arg Glu Asp Glu Asp Phe Glu Glu Ile Ser Lys 
                805                 810                 815     


Ile Ser Gln Met Ser Gln Pro Ser Gly Lys Glu Leu Asn Arg Tyr Lys 
            820                 825                 830         


Leu Trp Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Lys Ala Ile 
        835                 840                 845             


Ser Leu Ala Lys Leu Phe Thr Pro Ala Tyr Gln Ile Glu His Val Ile 
    850                 855                 860                 


Pro Gln Ser Arg Tyr Phe Asp Asp Ser Phe Thr Asn Lys Val Ile Cys 
865                 870                 875                 880 


Glu Ala Glu Val Asn Thr Leu Lys Ser Asn Leu Leu Gly Tyr Glu Phe 
                885                 890                 895     


Ile Lys Lys His Gly Gly Glu Ile Ile His Cys Thr Thr Leu Gly Asp 
            900                 905                 910         


Val Arg Ile Phe Ser Glu Ser Glu Tyr Lys Ala Phe Val Met Asp His 
        915                 920                 925             


Tyr Ala Asn Asn Lys Ser Lys Lys Asp Lys Leu Leu Met Glu Asp Ile 
    930                 935                 940                 


Pro Gln Glu Phe Leu Ser Arg Gln Met Asn Asp Ser Arg Tyr Ile Ser 
945                 950                 955                 960 


Lys Val Val Lys Thr Leu Leu Ser Asn Ile Val Arg Met Ala Asp Glu 
                965                 970                 975     


Ser Glu Ala Thr Ser Lys Ser Val Ile Val Cys Thr Gly Gly Val Thr 
            980                 985                 990         


Asp Arg Leu Lys Lys Asp Trp Gly  Leu Asn Asp Val Trp  Asn Ser Ile 
        995                 1000                 1005             


Val Tyr  Ser Arg Phe Glu Arg  Leu Asn Arg Leu Thr  Gly Thr Glu 
    1010                 1015                 1020             


Ala Phe  Gly His Trp Glu Asn  Lys Asp Gly Lys Arg  Val Phe Gln 
    1025                 1030                 1035             


Thr Ser  Met Pro Leu Glu Leu  Gln Arg Gly Phe Arg  Lys Lys Arg 
    1040                 1045                 1050             


Ile Asp  His Arg His His Ala  Met Asp Ala Leu Val  Ile Ala Cys 
    1055                 1060                 1065             


Ala Ser  Arg Asn Ile Val Asn  Tyr Leu Asn Asn Glu  Ser Ala Asn 
    1070                 1075                 1080             


Asn Pro  Lys Lys Arg Glu Asp  Leu Arg Arg Gln Leu  Cys Asp Lys 
    1085                 1090                 1095             


Asn Arg  Val Ile Arg Lys Pro  Trp Glu Thr Phe Thr  Gln Asp Ala 
    1100                 1105                 1110             


Tyr Asn  Ala Leu Glu Asn Val  Val Val Ser Phe Lys  Asn Tyr Val 
    1115                 1120                 1125             


Arg Val  Ile Asn Lys Ala Thr  Asn Arg Tyr Glu His  Tyr Asp Glu 
    1130                 1135                 1140             


Asn Gly  Lys Lys Arg Phe Val  Gln Gln Lys Gly Ser  Glu Leu Trp 
    1145                 1150                 1155             


Ala Ile  Arg Lys Pro Met His  Lys Glu Thr Tyr Tyr  Gly His Val 
    1160                 1165                 1170             


Asn Leu  Arg Arg Lys Glu Leu  Val Thr Leu Gln Lys  Ala Leu Asp 
    1175                 1180                 1185             


Asp Ile  Pro Ser Ile Cys Asp  Lys Lys Leu Arg Asp  Tyr Ile Ser 
    1190                 1195                 1200             


Ala Leu  Val Glu Lys His Phe  Asn Lys Arg Gln Leu  Leu Ala His 
    1205                 1210                 1215             


Phe Lys  Ser Thr Asp Tyr Tyr  Trp Gln Lys Gln Tyr  Val Asn Lys 
    1220                 1225                 1230             


Val Tyr  Val Trp Thr Phe Ser  Asp Asp Ile Lys Pro  Leu Val Ala 
    1235                 1240                 1245             


Thr Arg  Lys Leu Leu Asp Thr  Ser Phe Asp Ala Lys  Arg Ile Gly 
    1250                 1255                 1260             


Thr Ile  Thr Asp Thr Gly Ile  Gln Lys Ile Leu Arg  Asn Tyr Leu 
    1265                 1270                 1275             


Glu Ala  Lys Gly Gly Asn Ala  Thr Leu Ala Phe Thr  Pro Glu Gly 
    1280                 1285                 1290             


Ile Ala  Glu Met Asn Gln Asn  Ile Ser Lys Tyr Asn  Asp Gly Lys 
    1295                 1300                 1305             


Pro His  Gln Pro Ile Leu Lys  Val Arg Ile Thr Glu  Pro Met Gly 
    1310                 1315                 1320             


Ala Lys  Tyr Arg Val Gly Gln  Thr Gly Asn Lys Met  Ala Lys Tyr 
    1325                 1330                 1335             


Val Glu  Ala Gln Ser Gly Thr  Asn Leu Tyr Phe Ala  Ile Tyr Glu 
    1340                 1345                 1350             


Asp Ser  Glu Gly Lys Arg Ser  Tyr Thr Thr Val Pro  Leu Asp Glu 
    1355                 1360                 1365             


Val Ala  Glu Arg Leu Lys Gln  Arg Leu Ser Pro Val  Pro Glu Lys 
    1370                 1375                 1380             


Asp Glu  Asn Asp Val Pro Leu  Lys Phe Tyr Leu Ser  Pro Asn Asp 
    1385                 1390                 1395             


Leu Val  Tyr Val Pro Thr Glu  Glu Glu Leu Gln Leu  Arg Glu Cys 
    1400                 1405                 1410             


Lys Leu  Asn Lys Asp Arg Ile  Tyr Lys Met Val Ser  Ser Thr Gly 
    1415                 1420                 1425             


Asn Glu  Cys His Phe Ile Pro  Tyr Tyr Val Ala Asn  Val Ile Tyr 
    1430                 1435                 1440             


Asn Lys  Gly Gly Phe Asn Met  Gln Met His Arg Pro  Gln Ser 
    1445                 1450                 1455         


<210> 389
<211> 1218
<212> PRT
<213> Prevotella buccalis


<220>
<223> Prevotella buccalis ATCC 35310

<400> 389
Met Asn Lys Arg Ile Leu Gly Leu Asp Thr Gly Thr Asn Ser Leu Gly 
1               5                   10                  15      


Trp Ala Val Val Asp Trp Asp Glu His Ala Gln Ser Tyr Glu Leu Ile 
            20                  25                  30          


Lys Tyr Gly Asp Val Ile Phe Gln Glu Gly Val Lys Ile Glu Lys Gly 
        35                  40                  45              


Ile Glu Ser Ser Lys Ala Ala Glu Arg Ser Gly Tyr Lys Ala Ile Arg 
    50                  55                  60                  


Lys Gln Tyr Phe Arg Arg Arg Leu Arg Lys Ile Gln Val Leu Lys Val 
65                  70                  75                  80  


Leu Val Lys Tyr His Leu Cys Pro Tyr Leu Ser Asp Asp Asp Leu Arg 
                85                  90                  95      


Gln Trp His Leu Gln Lys Gln Tyr Pro Lys Ser Asp Glu Leu Met Leu 
            100                 105                 110         


Trp Gln Arg Thr Ser Asp Glu Glu Gly Lys Asn Pro Tyr Tyr Asp Arg 
        115                 120                 125             


His Arg Cys Leu His Glu Lys Leu Asp Leu Thr Val Glu Ala Asp Arg 
    130                 135                 140                 


Tyr Thr Leu Gly Arg Ala Leu Tyr His Leu Thr Gln Arg Arg Gly Phe 
145                 150                 155                 160 


Leu Ser Asn Arg Leu Asp Thr Ser Ala Asp Asn Lys Glu Asp Gly Val 
                165                 170                 175     


Val Lys Ser Gly Ile Ser Gln Leu Ser Thr Glu Met Glu Glu Ala Gly 
            180                 185                 190         


Cys Glu Tyr Leu Gly Asp Tyr Phe Tyr Lys Leu Tyr His Glu Gln Gly 
        195                 200                 205             


Asn Lys Val Arg Ile Arg Gln Arg Tyr Thr Asp Arg Lys Lys His Tyr 
    210                 215                 220                 


Gln His Glu Phe Asp Ala Ile Cys Glu Lys Gln Glu Leu Ser Ser Glu 
225                 230                 235                 240 


Leu Ile Glu Asp Leu Gln Arg Ala Ile Phe Phe Gln Leu Pro Leu Lys 
                245                 250                 255     


Ser Gln Arg His Gly Val Gly Arg Cys Thr Phe Glu Arg Gly Lys Pro 
            260                 265                 270         


Arg Cys Ala Asp Ser His Pro Asp Tyr Glu Glu Phe Arg Met Leu Cys 
        275                 280                 285             


Phe Val Asn Asn Ile Gln Val Lys Gly Pro His Asp Leu Glu Leu Arg 
    290                 295                 300                 


Pro Leu Thr Tyr Glu Glu Arg Glu Lys Ile Glu His Leu Phe Phe Arg 
305                 310                 315                 320 


Lys Ser Lys Pro Asn Phe Asp Phe Glu Asp Ile Ala Lys Glu Leu Ala 
                325                 330                 335     


Gly Lys Lys Asn Tyr Ala Trp Ile His Asp Lys Glu Glu Arg Ala Tyr 
            340                 345                 350         


Lys Phe Asn Tyr Arg Met Thr Gln Gly Val Pro Gly Cys Pro Thr Thr 
        355                 360                 365             


Ala Gln Leu Lys Ser Ile Phe Gly Asp Asp Trp Lys Thr Gly Ile Ala 
    370                 375                 380                 


Glu Thr Tyr Thr Leu Ile Gln Lys Lys Asn Gly Ser Lys Ser Leu Gln 
385                 390                 395                 400 


Glu Met Val Asp Asp Val Trp Asn Val Leu Tyr Ser Phe Ser Ser Val 
                405                 410                 415     


Glu Lys Leu Lys Glu Phe Ala His His Lys Leu Gln Leu Asp Glu Glu 
            420                 425                 430         


Asn Ala Glu Lys Phe Ala Lys Ile Lys Leu Ser His Ser Phe Ala Ala 
        435                 440                 445             


Leu Ser Leu Lys Ala Ile Arg Lys Phe Leu Pro Phe Leu Arg Lys Gly 
    450                 455                 460                 


Met Tyr Tyr Thr His Ala Ser Phe Phe Ala Asn Ile Pro Thr Ile Val 
465                 470                 475                 480 


Gly Lys Glu Ile Trp Asn Asn Glu Gln Ser Arg Lys Tyr Ile Met Glu 
                485                 490                 495     


Asn Val Gly Glu Leu Val Phe Asn Tyr Gln Pro Lys His Arg Asp Val 
            500                 505                 510         


Gln Gly Thr Ile Glu Met Leu Ile Lys Asp Phe Leu Ala Asn Asn Phe 
        515                 520                 525             


Glu Leu Pro Ala Gly Ala Thr Asp Lys Leu Tyr His Pro Ser Met Ile 
    530                 535                 540                 


Glu Thr Tyr Pro His Ala Leu Arg Asn Glu Phe Gly Ile Leu Gln Leu 
545                 550                 555                 560 


Gly Ser Pro Arg Thr Asn Ala Ile Arg Asn Pro Met Ala Met Arg Ser 
                565                 570                 575     


Leu His Val Leu Arg Arg Val Val Asn Gln Leu Leu Lys Glu Ser Ile 
            580                 585                 590         


Ile Asp Glu Asn Thr Glu Val His Val Glu Tyr Ala Arg Glu Leu Asn 
        595                 600                 605             


Asp Ala Asn Lys Arg Arg Ala Ile Ala Asp Arg Gln Lys Glu Gln Asp 
    610                 615                 620                 


Lys Gln His Lys Lys Tyr Gly Asp Glu Ile Arg Lys Leu Tyr Lys Glu 
625                 630                 635                 640 


Glu Thr Gly Lys Asp Ile Glu Pro Thr Gln Thr Asp Val Leu Lys Phe 
                645                 650                 655     


Gln Leu Trp Glu Glu Gln Asn His Tyr Cys Leu Tyr Thr Gly Glu Gln 
            660                 665                 670         


Ile Gly Ile Thr Asp Phe Ile Gly Ser Asn Pro Lys Phe Asp Ile Glu 
        675                 680                 685             


His Thr Ile Pro Gln Ser Val Gly Gly Asp Ser Thr Gln Met Asn Leu 
    690                 695                 700                 


Thr Leu Cys Asp Asn Arg Phe Asn Arg Glu Val Lys Lys Ala Lys Leu 
705                 710                 715                 720 


Pro Thr Glu Leu Ala Asn His Glu Glu Ile Leu Thr Arg Ile Glu Pro 
                725                 730                 735     


Trp Lys Asn Lys Tyr Glu Gln Leu Val Lys Glu Arg Asp Lys Gln Arg 
            740                 745                 750         


Thr Phe Ala Gly Met Asp Lys Ala Val Lys Asp Ile Arg Ile Gln Lys 
        755                 760                 765             


Arg His Lys Leu Gln Met Glu Ile Asp Tyr Trp Arg Gly Lys Tyr Glu 
    770                 775                 780                 


Arg Phe Thr Met Thr Glu Val Pro Glu Gly Phe Ser Arg Arg Gln Gly 
785                 790                 795                 800 


Thr Gly Ile Gly Leu Ile Ser Arg Tyr Ala Gly Leu Tyr Leu Lys Ser 
                805                 810                 815     


Leu Phe His Gln Ala Asp Ser Arg Asn Lys Ser Asn Val Tyr Val Val 
            820                 825                 830         


Lys Gly Val Ala Thr Ala Glu Phe Arg Lys Met Trp Gly Leu Gln Ser 
        835                 840                 845             


Glu Tyr Glu Lys Lys Cys Arg Asp Asn His Ser His His Cys Met Asp 
    850                 855                 860                 


Ala Ile Thr Ile Ala Cys Ile Gly Lys Arg Glu Tyr Asp Leu Met Ala 
865                 870                 875                 880 


Glu Tyr Tyr His Met Glu Glu Thr Phe Arg Gln Gly Arg Gly Ser Lys 
                885                 890                 895     


Pro Lys Phe Ser Lys Pro Trp Ala Thr Phe Thr Glu Asp Val Leu Asn 
            900                 905                 910         


Ile Tyr Lys Asn Leu Leu Val Val His Asp Thr Pro Asn Asn Met Pro 
        915                 920                 925             


Lys His Thr Lys Lys Tyr Val Gln Thr Ser Lys Gly Lys Val Leu Ala 
    930                 935                 940                 


Gln Gly Asp Thr Ala Arg Gly Ser Leu His Leu Asp Thr Tyr Tyr Gly 
945                 950                 955                 960 


Ala Ile Glu Arg Asp Gly Glu Ile Arg Tyr Val Val Arg Arg Pro Leu 
                965                 970                 975     


Ser Ser Phe Thr Asn Pro Lys Glu Leu Glu Asn Ile Val Asp Glu Thr 
            980                 985                 990         


Val Lys Arg Thr Ile Lys Glu Ala  Ile Ala Asp Lys Asn  Phe Lys Gln 
        995                 1000                 1005             


Ala Ile  Ala Glu Pro Ile Tyr  Met Asn Glu Asp Lys  Gly Ile Leu 
    1010                 1015                 1020             


Ile Lys  Lys Val Arg Cys Phe  Ala Asn Ser Val Lys  Gln Pro Ile 
    1025                 1030                 1035             


Asn Ile  Arg Gln His Arg Asp  Leu Ser Lys Lys Glu  Tyr Lys Gln 
    1040                 1045                 1050             


Gln Tyr  His Val Met Asn Glu  Asn Asn Tyr Leu Leu  Ala Ile Tyr 
    1055                 1060                 1065             


Glu Gly  Leu Val Lys Asn Lys  Val Val Arg Glu Phe  Glu Ile Val 
    1070                 1075                 1080             


Ser Tyr  Ile Glu Ala Ala Lys  Tyr Tyr Lys Arg Ser  Gln Asp Arg 
    1085                 1090                 1095             


Asn Ile  Phe Ser Ser Ile Val  Pro Thr His Ser Thr  Lys Tyr Gly 
    1100                 1105                 1110             


Leu Pro  Leu Lys Thr Lys Leu  Leu Met Gly Gln Gln  Val Leu Met 
    1115                 1120                 1125             


Phe Glu  Glu Asn Pro Asp Glu  Ile Gln Val Asp Asn  Thr Lys Asp 
    1130                 1135                 1140             


Leu Val  Lys Arg Leu Tyr Lys  Val Val Gly Ile Glu  Lys Asp Gly 
    1145                 1150                 1155             


Arg Ile  Lys Phe Lys His His  Gln Glu Ala Arg Lys  Glu Gly Leu 
    1160                 1165                 1170             


Thr Ile  Tyr Ser Thr Pro Tyr  Lys Asn Asn Asp Asp  Tyr Val Pro 
    1175                 1180                 1185             


Ile Phe  Arg Gln Ser Ile Lys  Asn Ile Asn Ile Leu  Val Asp Gly 
    1190                 1195                 1200             


Ile Asp  Phe Asn Ile Asp Ile  Leu Gly Lys Val Thr  Leu Lys Glu 
    1205                 1210                 1215             


<210> 390
<211> 1422
<212> PRT
<213> Prevotella denticola


<220>
<223> Prevotella denticola CRIS 18C-A

<400> 390
Met Thr Gln Lys Val Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly 
1               5                   10                  15      


Ser Ser Val Arg Asn Leu Asp Leu Ser Asp Asp Leu Lys Gly Gln Leu 
            20                  25                  30          


Glu Phe Phe Ser Ser Asp Ile Phe Arg Ser Ser Val Asn Lys Glu Ser 
        35                  40                  45              


Asn Gly Arg Glu Tyr Ser Leu Ala Ala Gln Arg Ser Ala His Ser Arg 
    50                  55                  60                  


Ser Arg Gly Leu Asn Glu Ala Arg Arg Arg Lys Leu Trp Ala Thr Leu 
65                  70                  75                  80  


Asp Leu Leu Ile Lys Tyr Gly Phe Cys Pro Met Ser Pro Glu Ser Leu 
                85                  90                  95      


Met Arg Trp Arg Thr Tyr Asp Lys Gln Arg Gly Leu Phe Arg Glu Tyr 
            100                 105                 110         


Pro Ile Asp Asp Lys Asn Phe Asn Ala Trp Ile Leu Leu Asp Phe Asp 
        115                 120                 125             


Gly Asp Gly Lys Pro Asp Tyr Ser Ser Pro Tyr Gln Leu Arg Arg Glu 
    130                 135                 140                 


Leu Val Ile Arg Gln Phe Asp Phe Asp Gln Pro Ile Glu Arg Tyr Lys 
145                 150                 155                 160 


Leu Gly Arg Ala Leu Tyr His Ile Ala Gln His Arg Gly Phe Lys Ser 
                165                 170                 175     


Ser Lys Gly Glu Thr Leu Ser Gln Gln Glu Thr Asn Ser Lys Gln Ser 
            180                 185                 190         


Leu Thr Asp Asp Thr Ala Asp Val Ala Gly Glu Met Lys Ala Ser Glu 
        195                 200                 205             


Glu Lys Leu Ser Lys Gly Leu Ser Thr Tyr Met Lys Glu Asn Asn Leu 
    210                 215                 220                 


Leu Thr Val Gly Ala Ala Phe Ala Gln Leu Glu Asp Glu Gly Val Arg 
225                 230                 235                 240 


Val Arg Asn Asn Asn Asp Tyr Arg Ala Ile Arg Ser Gln Phe Gln Arg 
                245                 250                 255     


Glu Ile Glu Thr Ile Phe Lys Phe Gln Gln Gly Leu Ser Val Glu Asn 
            260                 265                 270         


Glu Leu Tyr Glu Arg Leu Val Ser Glu Lys Lys Asn Ile Gly Thr Ile 
        275                 280                 285             


Phe Tyr Lys Arg Pro Leu Arg Ser Gln Arg Gly Asn Val Gly Lys Cys 
    290                 295                 300                 


Thr Leu Glu Arg Thr Lys Pro Arg Cys Ala Ile Gly His Pro Leu Phe 
305                 310                 315                 320 


Glu Lys Phe Arg Ala Trp Thr Leu Ile Asn Asn Ile Lys Val Arg Met 
                325                 330                 335     


Ser Glu Glu Glu Gln Ala Glu Gln Leu Pro Met Lys Leu Arg Phe Glu 
            340                 345                 350         


Leu Tyr Asn Asp Cys Phe Leu Ala Phe Val Arg Ala Glu Phe Lys Phe 
        355                 360                 365             


Glu Asp Ile Arg Lys Tyr Leu Glu Lys Arg Leu Gly Val His Phe Ser 
    370                 375                 380                 


Tyr Asn Asp Lys Thr Ile Asn Tyr Lys Asp Ser Thr Ser Val Ala Gly 
385                 390                 395                 400 


Cys Pro Ile Thr Ala Arg Phe Arg Lys Leu Leu Gly Glu Asp Trp Glu 
                405                 410                 415     


Ser Phe His Val Asp Gly Gln Lys Gln Arg Gln Ala His Gly Lys Asn 
            420                 425                 430         


Asn Ala Ser Phe His Thr Val Ser Tyr Ser Thr Asn Asp Ile Trp His 
        435                 440                 445             


Phe Cys Tyr Asp Ala Glu Glu Pro Glu Ala Val Leu Ser Phe Ala Gln 
    450                 455                 460                 


Asp Asn Leu Lys Trp Glu Lys Lys Lys Ala Glu Glu Leu Val Arg Ile 
465                 470                 475                 480 


Trp Ser Ala Ile Pro Gln Gly Tyr Ala Met Leu Ser Gln Lys Ala Ile 
                485                 490                 495     


Arg Asn Ile Asn Lys Met Leu Ile Leu Gly Leu Lys Tyr Ser Asp Ala 
            500                 505                 510         


Val Leu Leu Ala Lys Val Pro Glu Ile Val Glu Ile Thr Asp Gly Glu 
        515                 520                 525             


Ile Leu Ser Val Thr Glu Asp Tyr His Arg Val Glu Ala Gln Val Gly 
    530                 535                 540                 


Tyr Glu Lys Gln Ile Asn Asn Ile Val Asn Ala Leu Ile Ala Lys Tyr 
545                 550                 555                 560 


Lys Ser Ala Ser Glu Glu Tyr Arg Phe Ala Asp His Asn Tyr Glu Tyr 
                565                 570                 575     


Gln Leu Asp Lys Ser Asp Glu Lys Asp Ile Ile Lys Gln Ile Glu Ser 
            580                 585                 590         


Asn Ile Gly Thr Arg Lys Trp Ser Leu Leu Asp Ala Asp Glu Gln Thr 
        595                 600                 605             


Asp Ile Leu Gln Lys Val Arg Asp Lys Tyr Gln Asn Phe Phe Arg Ser 
    610                 615                 620                 


His Glu Arg Lys Phe Val Glu Ser Pro Lys Leu Gly Glu Cys Phe Glu 
625                 630                 635                 640 


Glu Tyr Leu Met Lys Lys Phe Pro Met Val Glu Gly Glu Arg Trp Lys 
                645                 650                 655     


Lys Leu Tyr His Pro Ser Gln Ile Ala Ile Tyr Arg Pro Val Pro Ala 
            660                 665                 670         


Asn Lys Asp Arg Ser Ala Leu Arg Leu Gly Asn Pro Asp Ile Gly Ala 
        675                 680                 685             


Ile Lys Asn Pro Thr Val Leu Arg Val Leu Asn Thr Leu Arg Lys Arg 
    690                 695                 700                 


Val Asn Gln Leu Leu Asp Asp Gly Ile Ile Ser Pro Asp Glu Thr Arg 
705                 710                 715                 720 


Val Val Val Glu Thr Ala Arg Glu Leu Asn Asp Ala Asn Arg Lys Trp 
                725                 730                 735     


Ala Leu Asp Thr Tyr Asn Arg Ile Arg His Asp Glu Asn Glu Lys Ile 
            740                 745                 750         


Lys Lys Ile Leu Ala Glu Phe Tyr Pro Lys Arg Asp Asn Ile Ser Thr 
        755                 760                 765             


Val Asp Ile Asp Lys Ala Arg Tyr Val Ile Asp Gln Arg Glu Met Asp 
    770                 775                 780                 


Tyr Phe Thr Glu Ala Lys Thr Tyr His Lys Asp Ile Lys Lys Tyr Lys 
785                 790                 795                 800 


Leu Trp Leu Glu Gln Gly Gly Gln Cys Met Tyr Thr Gly Arg Thr Ile 
                805                 810                 815     


Asn Leu Ser Asn Leu Phe Asp Pro Asn Ser Phe Asp Val Glu His Thr 
            820                 825                 830         


Ile Pro Glu Ser Ile Ser Phe Asp Ser Ser Asp Met Asn Leu Thr Leu 
        835                 840                 845             


Cys Asp Ala His Tyr Asn Arg Phe Ile Lys Lys Asn His Ile Pro Ala 
    850                 855                 860                 


Asp Leu Pro Asn Tyr Asp Lys Ser Val Val Ile Asp Gly Lys Glu Tyr 
865                 870                 875                 880 


Ser Pro Ile Lys Pro Arg Leu Gln Arg Trp Ala Asp Arg Val Glu Arg 
                885                 890                 895     


Leu Asn Arg Asn Val Glu Tyr Trp Arg Gly Gln Ala Arg Arg Ala Gln 
            900                 905                 910         


Asn Lys Asp Arg Lys Asp Gln Cys Met Arg Glu Met His Leu Trp Lys 
        915                 920                 925             


Met Glu Leu Glu Tyr Trp Thr Lys Lys Leu Glu Arg Phe Thr Ile Thr 
    930                 935                 940                 


Glu Val Thr Asp Glu Phe Lys Asn Ser Gln Leu Val Asp Thr Arg Val 
945                 950                 955                 960 


Ile Thr Arg His Ala Val Leu Tyr Leu Lys Ser Ile Phe Pro His Val 
                965                 970                 975     


Asp Val Gln Arg Gly Asp Val Thr Ala Lys Phe Arg Lys Ile Leu Gly 
            980                 985                 990         


Ile Gln Ser Val Asp Glu Lys Lys  Asp Arg Ser Leu His  Ser His His 
        995                 1000                 1005             


Ala Ile  Asp Ala Thr Thr Leu  Thr Ile Ile Pro Gly  Ala Ala Lys 
    1010                 1015                 1020             


Arg Glu  Arg Met Leu Glu Leu  Phe Ala Lys Ile Glu  Glu Val Asn 
    1025                 1030                 1035             


Lys Met  Leu Ser Phe Ser Gly  Asn Glu Asp Arg Thr  Gly Leu Lys 
    1040                 1045                 1050             


Gln Glu  Leu Asp Gly Leu Lys  Asn Gln Leu Asn Lys  Glu Val Lys 
    1055                 1060                 1065             


Ala Cys  Arg Ile Gly His Asn  Val Ser Glu Ile Gly  Thr Phe Ile 
    1070                 1075                 1080             


Asn Asp  Asn Ile Ile Ile Asn  His His Val Lys Asn  Gln Ala Leu 
    1085                 1090                 1095             


Thr Pro  Val Arg Arg Arg Leu  Arg Lys Arg Gly His  Ile Val Gly 
    1100                 1105                 1110             


Gly Met  Asp Asn Pro Arg Trp  Gln Thr Gly Asp Ala  Leu Arg Gly 
    1115                 1120                 1125             


Glu Ile  His Lys Ala Ser Tyr  Tyr Gly Ala Ile Thr  Gln Tyr Ala 
    1130                 1135                 1140             


Lys Asp  Lys Glu Gly Lys Val  Leu Met Lys Glu Gly  Arg Pro Gln 
    1145                 1150                 1155             


Ile Asn  Pro Thr Ile Lys Phe  Val Ile Arg Arg Glu  Leu Lys Tyr 
    1160                 1165                 1170             


Lys Lys  Ser Ser Thr Asp Ser  Gly Phe Ala Ser Trp  Asp Asp Leu 
    1175                 1180                 1185             


Gly Lys  Ala Ile Val Asp Lys  Glu Leu Phe Ala Leu  Met Lys Gly 
    1190                 1195                 1200             


Gln Phe  Pro Glu Gly Thr Ser  Phe Lys Asp Ala Cys  Glu Gln Gly 
    1205                 1210                 1215             


Ile Tyr  Met Ile Lys Lys Gly  Lys Asn Gly Glu Val  Asp Thr Lys 
    1220                 1225                 1230             


Leu Tyr  Arg Ile Arg His Ile  Arg Cys Lys Thr Lys  Gln Lys Asn 
    1235                 1240                 1245             


Ala Leu  Lys Ile Lys Glu Gln  Ala Tyr Lys Ser Glu  Lys Glu Tyr 
    1250                 1255                 1260             


Lys Arg  Tyr Phe Tyr Ala Ala  Val Gly Asp Leu Tyr  Ala Met Cys 
    1265                 1270                 1275             


Cys Tyr  Thr Asn Gly Lys Thr  Arg Glu Phe Lys Ile  Tyr Ser Leu 
    1280                 1285                 1290             


Tyr Asp  Ile Ser Cys His Arg  Lys Val Gly Val Glu  Asp Ile Pro 
    1295                 1300                 1305             


Glu Phe  Ile Thr Asp Lys Lys  Gly Asn Arg Leu Met  Leu Asp Tyr 
    1310                 1315                 1320             


Lys Leu  His Thr Gly Asp Met  Ile Leu Leu Tyr Lys  Glu Asn Pro 
    1325                 1330                 1335             


Glu Glu  Leu Tyr Asp Leu Asp  Asn Val Ser Leu Ser  Lys Leu Leu 
    1340                 1345                 1350             


Tyr Lys  Ile Asn Gly Phe Glu  Asn Asp Gly Leu Arg  Ile Arg Met 
    1355                 1360                 1365             


Val Asn  His Leu Val Ala Lys  Glu Ala Met Gly Glu  Ser Val Lys 
    1370                 1375                 1380             


Asp Tyr  Ala Lys Leu Pro Asp  Ile Ile Arg Cys Gly  Val Lys Thr 
    1385                 1390                 1395             


Ile Lys  Phe Leu Val Met Gly  Glu Asn Arg Asp Phe  Val Ile Lys 
    1400                 1405                 1410             


Asn Gly  Lys Ile Ser Phe Asn  His Arg 
    1415                 1420         


<210> 391
<211> 1375
<212> PRT
<213> Prevotella histicola


<220>
<223> Prevotella histicola F0411

<400> 391
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Tyr Glu Ser Glu Asn Thr Asp Glu Lys Ser Ser Ile Val 
            20                  25                  30          


Arg Leu Gly Val Arg Val Asn Pro Leu Ser Val Asp Glu Lys Gly Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ala Ile Thr Thr Asn Ala Asp Arg Gln Gln Thr 
    50                  55                  60                  


His Gly Ala Arg Ile Asn Leu Gln Arg Tyr Lys Leu Arg Arg Glu Asn 
65                  70                  75                  80  


Leu Lys Asp Cys Leu Gln Lys Gln Gly Trp Ile Gly Thr Glu Ala Leu 
                85                  90                  95      


Cys Glu Glu Gly Lys Thr Ser Thr Phe Glu Thr Tyr Met Leu Arg Ala 
            100                 105                 110         


Lys Ala Ala Glu Glu Glu Ile Ser Leu His Glu Leu Cys Arg Val Leu 
        115                 120                 125             


Phe Met Met Asn Lys Lys Arg Gly Tyr Lys Ser Asn Arg Lys Ala Asn 
    130                 135                 140                 


Asn Lys Glu Asp Gly Lys Leu Phe Asp Gly Met Thr Val Ala Lys Lys 
145                 150                 155                 160 


Leu Tyr Glu Glu His Leu Thr Pro Ala Glu Tyr Ser Phe Gln Leu Leu 
                165                 170                 175     


Ser Ser Gly Lys Lys Phe Lys Gln Glu Tyr Tyr Arg Ser Asp Leu Lys 
            180                 185                 190         


Glu Glu Phe Asp Arg Ile Trp Asn Glu Gln Gln Lys Tyr Tyr Pro Glu 
        195                 200                 205             


Ile Leu Thr Asp Asp Phe Lys Gln Gln Leu Gln Gly Lys Ser Lys Gly 
    210                 215                 220                 


Asn Thr Ser Lys Ile Phe Leu Gly Lys Tyr Gly Ile Tyr Ser Ala Asp 
225                 230                 235                 240 


Leu Lys Gly Leu Asp Arg Lys Leu Gln Pro Leu Lys Trp Arg Val Glu 
                245                 250                 255     


Ala Leu Lys Gln Gln Val Asp Lys Glu Val Leu Ala Phe Val Ile Ser 
            260                 265                 270         


Asp Leu Asn Gly Gln Ile Ala Ser Thr Ser Gly Leu Leu Gly Ala Ile 
        275                 280                 285             


Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Lys Gln Thr Val Gly Gln 
    290                 295                 300                 


Tyr Leu Trp Thr Ser Leu Lys Glu Thr Pro His Val Ser Ile Lys Asn 
305                 310                 315                 320 


Lys Pro Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu Lys Ile Trp 
                325                 330                 335     


Glu Thr Gln Ala Thr Tyr His Lys Glu Leu Thr Pro Glu Leu Lys Gln 
            340                 345                 350         


Glu Ile Arg Asp Ile Ile Ile Phe Tyr Gln Arg Pro Leu Lys Ser Lys 
        355                 360                 365             


Lys Gly Leu Ile Ser Val Cys Glu Leu Glu Gln Arg Lys Val Lys Val 
    370                 375                 380                 


Thr Ile Asp Gly Lys Glu Lys Glu Ile Ser Ile Gly Pro Lys Val Ala 
385                 390                 395                 400 


Pro Lys Ser Ser Pro Met Phe Gln Glu Phe Arg Ile Trp Gln Asn Leu 
                405                 410                 415     


Asn Asn Ile Leu Leu Ile Asp Lys Gly Asn Asn Ser Ile His Pro Leu 
            420                 425                 430         


Tyr Glu Glu Glu Lys Asn Leu Leu Tyr Glu Glu Leu Ser Val Lys Glu 
        435                 440                 445             


Lys Leu Ser Lys Ala Glu Ala Leu Lys Val Leu Asn Lys Asn Ser Lys 
    450                 455                 460                 


Gln Trp Asp Leu Asn Tyr Lys Glu Ile Glu Gly Asn Arg Thr Gln Ala 
465                 470                 475                 480 


Val Leu Tyr Asp Cys Tyr Asn Arg Ile Ile Val Met Thr Gly His Glu 
                485                 490                 495     


Glu Tyr Asn Phe Lys Lys Leu Lys Ala Ser Glu Ile Arg Ser Tyr Val 
            500                 505                 510         


Lys Thr Thr Phe Thr Gly Leu Gly Phe Asn Thr Asp Ile Leu Glu Phe 
        515                 520                 525             


Asp Ser Ser Leu Thr Gly His Glu Leu Glu Lys Gln Pro Met Tyr Gln 
    530                 535                 540                 


Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asn Ser Arg Thr Gly 
545                 550                 555                 560 


Asn Asp Ala Leu Leu Arg Lys Leu Glu Thr Ala Phe Gly Phe Pro Lys 
                565                 570                 575     


Glu Tyr Ala Ala Val Leu Ser Asp Val Val Phe Glu Asp Ser Tyr Gly 
            580                 585                 590         


Asn Leu Ser Val Lys Ala Met Arg Lys Ile Leu Pro His Leu Gln Ala 
        595                 600                 605             


Gly Leu Asn Tyr Ser Gln Ala Cys Glu Glu Ala Gly Tyr Lys His Ser 
    610                 615                 620                 


Arg Arg Ser Leu Thr Lys Asn Glu Leu Asp Gln Lys Glu Tyr Lys Glu 
625                 630                 635                 640 


Lys Leu Glu Leu Leu Pro Lys Asn Ser Leu His Asn Pro Val Val Glu 
                645                 650                 655     


Lys Ile Leu Asn Gln Met Ile Asn Val Ile Asn Ala Val Ile Asp Glu 
            660                 665                 670         


Tyr Gly Lys Pro Asp Glu Ile Arg Ile Glu Leu Ala Arg Glu Leu Lys 
        675                 680                 685             


Ile Gly Ala Ala Glu Arg Glu Asn Met Thr Arg Ser Ile Asn Gln Gly 
    690                 695                 700                 


Asn Ala Glu Asn Lys Arg Ile Arg Glu Ile Leu Glu Lys Glu Phe Ala 
705                 710                 715                 720 


Leu Ser Tyr Ile Ser Arg Asn Asp Ile Ile Lys Tyr Lys Leu Tyr Glu 
                725                 730                 735     


Glu Leu Lys Ser Asn Gly Phe Lys Thr Leu Tyr Ser Asp Thr Tyr Ile 
            740                 745                 750         


Ser Lys Asp Lys Leu Phe Ser Lys Asp Phe Asp Ile Glu His Ile Ile 
        755                 760                 765             


Pro Lys Ala Arg Leu Phe Asp Asp Ser Leu Ser Asn Lys Thr Ile Glu 
    770                 775                 780                 


Ala Arg Asp Val Asn Ile Ala Lys Ser Asn Lys Thr Ala Phe Asp Phe 
785                 790                 795                 800 


Ile Ser Glu Lys Tyr Asp Gln Gln Gly Ile Glu Ala Tyr Lys Lys Lys 
                805                 810                 815     


Leu Asp Ile Leu Leu Gln Asp Gly Ser Ile Ser Lys Ala Lys Tyr Asn 
            820                 825                 830         


Arg Leu Leu Met Lys Glu Ala Asp Ile Pro Ser Gly Phe Ile Asp Arg 
        835                 840                 845             


Asp Leu Arg Asp Thr Gln Tyr Ile Ala Lys Lys Ala Tyr Glu Ile Leu 
    850                 855                 860                 


Ser Asp Leu Val Arg Asn Val Thr Pro Thr Thr Gly Ala Val Thr Ser 
865                 870                 875                 880 


Arg Leu Arg Glu Asp Trp Gln Leu Val Asp Val Met Lys Glu Leu Asn 
                885                 890                 895     


Phe Glu Lys Tyr Gln Lys Leu Gly Leu Val Glu Val Ile Glu Asp Arg 
            900                 905                 910         


Asp Gly Arg Lys Ile Lys Arg Ile Lys Asp Trp Thr Lys Arg Asn Asp 
        915                 920                 925             


His Arg His His Ala Met Asp Ala Leu Thr Ile Ala Phe Thr Lys Pro 
    930                 935                 940                 


Ser Tyr Ile Gln Tyr Leu Asn Asn Leu Asn Ala Arg Ser Asp Lys Asn 
945                 950                 955                 960 


Ser Ser Ile Tyr Gly Ile Glu Asn Lys Glu Leu His Arg Glu Asp Asn 
                965                 970                 975     


Lys Leu Arg Phe Asn Ala Pro Leu Pro Ile Asn Glu Phe Arg Ala Glu 
            980                 985                 990         


Ala Arg Arg His Leu Lys Ser Ile  Leu Val Ser Val Lys  Ala Lys Asn 
        995                 1000                 1005             


Lys Val  Met Thr Gln Asn Val  Asn Val Ile Lys Thr  Lys His Gly 
    1010                 1015                 1020             


Val Ile  Lys Lys Val Gln Leu  Thr Pro Arg Gly Glu  Leu His Asn 
    1025                 1030                 1035             


Ala Thr  Phe Tyr Gly Thr Lys  Lys Arg Pro Ile Ile  Lys Met Val 
    1040                 1045                 1050             


Lys Val  Gly Ala Ala Leu Asp  Glu Val Thr Ile Lys  Lys Val Ser 
    1055                 1060                 1065             


Ser Ser  Phe Ile Arg Glu Ala  Leu Leu Asp Arg Leu  His Glu Tyr 
    1070                 1075                 1080             


Asn Gly  Asp Ala Lys Lys Ala  Phe Thr Gly Arg Asn  Ser Ile Asp 
    1085                 1090                 1095             


Lys Asn  Pro Ile Tyr Ile Asp  Glu Glu His Lys Lys  Thr Val Pro 
    1100                 1105                 1110             


Ala Leu  Val Lys Thr Ile Glu  Trp Glu Met Tyr His  Pro Thr Arg 
    1115                 1120                 1125             


Lys Leu  Ile Ser Pro Asp Leu  Lys Ile Asp Lys Val  Ile Asp Lys 
    1130                 1135                 1140             


Gly Ile  Arg Glu Ile Leu Lys  Thr Arg Leu Ala Lys  Phe Asn Gly 
    1145                 1150                 1155             


Asp Ala  Gln Lys Ala Phe Ser  Asn Leu Asp Glu Asn  Pro Ile Tyr 
    1160                 1165                 1170             


Lys Asp  Glu Ala Lys Lys Ile  Thr Leu Lys Arg Val  Ser Leu Glu 
    1175                 1180                 1185             


Gly Val  Ser Ser Val Ile Pro  Leu His Thr Leu Lys  Asp Arg Glu 
    1190                 1195                 1200             


Gly Lys  Leu Val Val Gly Lys  Asp Gly Lys Pro Val  Leu Gly Asp 
    1205                 1210                 1215             


Tyr Val  Gln Thr Ser Asn Asn  His His Ile Ala Phe  Tyr Met Asp 
    1220                 1225                 1230             


Glu Asn  Gly Asn Leu Gln Asp  Asn Val Val Ser Phe  Phe Glu Ala 
    1235                 1240                 1245             


Ala Glu  Arg Lys Ser Gln Gly  Val Pro Val Ile Asp  Lys Asn Tyr 
    1250                 1255                 1260             


Asn His  Asp Lys Gly Trp Asn  Phe Leu Phe Thr Met  Lys Gln Asn 
    1265                 1270                 1275             


Glu Tyr  Phe Val Phe Pro Asn  Glu Val Thr Gly Phe  Asn Pro Ser 
    1280                 1285                 1290             


Glu Val  Asp Leu Met Asp Glu  Ala Asn Tyr Ser Ile  Ile Ser Pro 
    1295                 1300                 1305             


Asn Leu  Tyr Arg Val Gln Lys  Met Ser Lys Ala Ser  Gly Arg Asp 
    1310                 1315                 1320             


Tyr Trp  Phe Arg His His Leu  Glu Ala Met Leu Asn  Asp Asp Pro 
    1325                 1330                 1335             


Lys Leu  Arg Asn Ser Met Phe  Lys Arg Ile Thr Ser  Leu Lys Ala 
    1340                 1345                 1350             


Leu Glu  Gly Ile Val Lys Val  Arg Ile Asn Cys Ile  Gly Lys Ile 
    1355                 1360                 1365             


Val Ala  Val Gly Glu Tyr Asp  
    1370                 1375 


<210> 392
<211> 1380
<212> PRT
<213> Prevotella intermedia

<400> 392
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Glu Asn Asn Asn Glu Ala Ser Ser Ile Val 
            20                  25                  30          


Arg Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Lys Ser Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ala Ile Thr Thr Asn Ala Asp Arg Gln Leu Arg 
    50                  55                  60                  


His Gly Ala Arg Ile Asn Leu Gln Arg Tyr Lys Leu Arg Arg Gln Asn 
65                  70                  75                  80  


Leu His Asp Cys Leu Gln Lys Gln Gly Trp Leu Gly Thr Glu Ala Met 
                85                  90                  95      


Tyr Glu Glu Gly Lys Ala Ser Thr Phe Glu Thr Tyr Lys Leu Arg Ala 
            100                 105                 110         


Lys Ala Ala Glu Glu Glu Ile Ser Leu His Glu Phe Ala Arg Val Leu 
        115                 120                 125             


Phe Met Leu Asn Lys Lys Arg Gly Tyr Lys Ser Asn Arg Lys Ala Asn 
    130                 135                 140                 


Asn Lys Glu Asp Gly Gln Leu Phe Asp Gly Met Thr Ile Ala Lys Lys 
145                 150                 155                 160 


Leu Tyr Glu Glu His Leu Thr Pro Ala Glu Tyr Ser Leu Gln Leu Leu 
                165                 170                 175     


Asn Lys Gly Lys Lys Phe Thr Gln Gly Tyr Tyr Arg Ser Asp Leu Asn 
            180                 185                 190         


Ala Glu Leu Glu Arg Ile Trp Asp Glu Gln Lys Lys Tyr Tyr Pro Glu 
        195                 200                 205             


Ile Leu Thr Asp Glu Phe Lys Gln Gln Leu Glu Gly Lys Thr Lys Thr 
    210                 215                 220                 


Asn Thr Ser Lys Ile Phe Leu Ala Lys Tyr Gly Ile Tyr Ser Ala Asp 
225                 230                 235                 240 


Leu Lys Gly Leu Asp Arg Lys Phe Gln Pro Leu Lys Trp Arg Val Glu 
                245                 250                 255     


Ala Leu Gln Gln Gln Val Asp Lys Glu Val Leu Ala Phe Val Ile Ser 
            260                 265                 270         


Asp Leu Lys Gly Gln Ile Ala Asn Thr Ser Gly Leu Leu Gly Ala Ile 
        275                 280                 285             


Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Lys Gln Thr Val Gly Gln 
    290                 295                 300                 


Tyr Leu Trp Ala Ser Leu Glu Glu Asn Pro His Ile Ser Ile Lys Asn 
305                 310                 315                 320 


Lys Pro Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu Lys Ile Trp 
                325                 330                 335     


Glu Thr Gln Ala Ala Phe His Lys Gln Leu Thr Pro Glu Leu Lys Gln 
            340                 345                 350         


Glu Ile Arg Asp Ile Ile Ile Phe Tyr Gln Arg Pro Leu Lys Ser Lys 
        355                 360                 365             


Lys Ser Leu Ile Ser Val Cys Glu Leu Glu Gln Arg Lys Val Lys Ala 
    370                 375                 380                 


Thr Ile Asp Gly Lys Glu Lys Glu Ile Thr Ile Gly Pro Lys Val Ala 
385                 390                 395                 400 


Pro Lys Ser Ser Pro Val Phe Gln Glu Phe Arg Ile Trp Gln Asn Leu 
                405                 410                 415     


Asn Asn Val Leu Leu Ile Asp Asn Asp Thr Asn Glu Lys Arg Pro Leu 
            420                 425                 430         


Asp Glu Val Glu Arg Asn Leu Leu Tyr Lys Glu Leu Ser Ile Lys Ala 
        435                 440                 445             


Lys Leu Ser Lys Thr Glu Ala Leu Lys Ile Leu Asn Lys Lys Gly Lys 
    450                 455                 460                 


Gln Trp Asp Leu Asn Tyr Arg Glu Leu Glu Gly Asn Arg Thr Gln Ala 
465                 470                 475                 480 


Ile Leu Phe Asp Cys Tyr Asn Arg Ile Ile Thr Leu Thr Gly His Glu 
                485                 490                 495     


Glu Cys Asp Phe Lys Lys Ile Lys Ala Ser Glu Ile Arg His Tyr Val 
            500                 505                 510         


Ser Thr Ile Phe Lys Asn Leu Gly Phe Ser Thr Glu Ile Leu Asp Phe 
        515                 520                 525             


Asp Pro Ser Leu Lys Lys His Glu Leu Glu Lys Gln Pro Met Tyr Gln 
    530                 535                 540                 


Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asn Ser Arg Thr Gly 
545                 550                 555                 560 


Asn Glu Ser Leu Leu Arg Lys Leu Glu Thr Thr Phe Gly Phe Pro Glu 
                565                 570                 575     


Glu Tyr Ala Thr Val Leu Cys Asp Val Val Phe Glu Glu Asp Tyr Gly 
            580                 585                 590         


Asn Leu Ser Val Lys Ala Met Arg Glu Ile Leu Pro Tyr Leu Gln Ala 
        595                 600                 605             


Gly Asn Asp Tyr Ser Gln Ala Cys Ala Tyr Ala Gly Tyr Asn His Ser 
    610                 615                 620                 


Arg His Ser Leu Thr Lys Glu Glu Leu Asp Gln Lys Val Tyr Lys Glu 
625                 630                 635                 640 


Arg Leu Glu Leu Leu Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu 
                645                 650                 655     


Lys Ile Leu Asn Gln Met Ile Asn Val Ile Asn Ala Ile Ile Asp Glu 
            660                 665                 670         


Tyr Gly Lys Pro Asp Glu Ile Arg Ile Glu Met Ala Arg Glu Leu Lys 
        675                 680                 685             


Ser Ser Ala Ala Asp Arg Lys Lys Thr Thr His Ala Ile Ser Gln Gly 
    690                 695                 700                 


Asn Ala Glu Asn Gln Arg Ile Arg Glu Ile Leu Glu Lys Glu Phe Ser 
705                 710                 715                 720 


Leu Ser Tyr Ile Ser Arg Asn Asp Ile Ile Lys Tyr Lys Leu Tyr Glu 
                725                 730                 735     


Glu Leu Glu Pro Asn Tyr Tyr Lys Thr Leu Tyr Ser Asp Thr Tyr Ile 
            740                 745                 750         


Thr Lys Asp Lys Leu Phe Ser Lys Asp Phe Asp Ile Glu His Ile Ile 
        755                 760                 765             


Pro Lys Ala Arg Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Glu 
    770                 775                 780                 


Ala Arg Asn Ile Asn Leu Glu Lys Ser Asn Lys Thr Ala Phe Asp Phe 
785                 790                 795                 800 


Ile Lys Glu Lys Tyr Gly Glu Asp Gly Ala Glu Ala Tyr Lys Lys Lys 
                805                 810                 815     


Leu Asp Met Leu Leu Glu Asn Asp Ala Ile Ser Arg Pro Lys Tyr Asn 
            820                 825                 830         


Asn Leu Leu Arg Ala Glu Ala Asp Ile Pro Ser Asp Phe Ile Asn Arg 
        835                 840                 845             


Asp Leu Arg Asn Thr Gln Tyr Ile Ala Lys Lys Ala Cys Glu Ile Leu 
    850                 855                 860                 


Gly Glu Leu Val Lys Thr Val Thr Pro Thr Thr Gly Lys Ile Thr Asn 
865                 870                 875                 880 


Arg Leu Arg Glu Asp Trp Gln Leu Val Asp Val Met Lys Glu Leu Asn 
                885                 890                 895     


Phe Glu Lys Tyr Glu Lys Leu Gly Leu Thr Glu Ile Val Glu Asp Arg 
            900                 905                 910         


Asp Gly Arg Lys Ile Lys Arg Ile Lys Asp Trp Thr Lys Arg Asn Asp 
        915                 920                 925             


His Arg His His Ala Met Asp Ala Leu Ala Ile Ala Phe Thr Lys Pro 
    930                 935                 940                 


Ser Phe Ile Gln Tyr Leu Asn Asn Leu Asn Ala Arg Ser Asn Lys Gly 
945                 950                 955                 960 


Asp Ser Ile Tyr Ala Ile Glu Asn Lys Glu Leu His Tyr Glu Glu Gly 
                965                 970                 975     


Lys Leu Arg Phe Asn Ala Pro Ile Pro Val Asn Glu Phe Arg Ala Glu 
            980                 985                 990         


Ala Lys Arg His Leu Ser Ala Ile  Leu Val Ser Ile Lys  Ala Lys Asn 
        995                 1000                 1005             


Lys Val  Met Thr Gln Asn Val  Asn Lys Ile Lys Thr  Lys His Gly 
    1010                 1015                 1020             


Ile Ile  Lys Lys Ile Gln Leu  Thr Pro Arg Gly Pro  Leu His Asn 
    1025                 1030                 1035             


Glu Thr  Ile Tyr Gly Thr Lys  Met Arg Pro Ile Ile  Lys Met Val 
    1040                 1045                 1050             


Lys Val  Gly Ala Ala Leu Asp  Glu Ala Thr Ile Asn  Lys Val Ser 
    1055                 1060                 1065             


Ser Pro  Ala Ile Arg Glu Ala  Leu Leu Lys Arg Leu  Asn Glu Tyr 
    1070                 1075                 1080             


Ser Gly  Asn Ala Lys Lys Ala  Phe Thr Gly Lys Asn  Thr Leu Glu 
    1085                 1090                 1095             


Lys Asn  Pro Ile Tyr Leu Asn  Ala Gly Arg Thr Lys  Thr Val Pro 
    1100                 1105                 1110             


Ser Leu  Val Lys Thr Val Glu  Trp Glu Ser Phe His  Pro Thr Arg 
    1115                 1120                 1125             


Lys Leu  Ile Asp Lys Asp Leu  Asn Val Asp Lys Val  Val Asp Lys 
    1130                 1135                 1140             


Gly Ile  Arg Glu Ile Leu Lys  Ala Arg Leu Glu Glu  Phe Asn Gly 
    1145                 1150                 1155             


Asp Ala  Lys Lys Ala Phe Ser  Asn Leu Glu Glu Asn  Pro Ile Tyr 
    1160                 1165                 1170             


Leu Asp  Glu Ala Lys Lys Ile  Ala Leu Lys Arg Val  Ser Ile Glu 
    1175                 1180                 1185             


Gly Val  Leu Ser Ala Ile Pro  Leu His Thr Leu Lys  Asn Gln Ala 
    1190                 1195                 1200             


Gly Lys  Pro Ile Thr Gly Lys  Asp Gly Lys Pro Val  Leu Gly Asn 
    1205                 1210                 1215             


Tyr Val  Gln Thr Ser Asn Asn  His His Ile Ala Phe  Tyr Tyr Asp 
    1220                 1225                 1230             


Glu Asp  Gly Asn Leu Gln Asp  Asn Ala Val Ser Phe  Phe Glu Ala 
    1235                 1240                 1245             


Ala Glu  Arg Lys Ser Gln Gly  Ile Pro Val Ile Asp  Lys Asp Tyr 
    1250                 1255                 1260             


Asn Arg  Asp Lys Gly Trp Arg  Phe Leu Phe Thr Met  Lys Gln Asn 
    1265                 1270                 1275             


Glu Tyr  Phe Val Phe Pro Asn  Glu Ala Thr Gly Phe  Ile Pro Ser 
    1280                 1285                 1290             


Glu Val  Asp Leu Thr Asp Glu  Ala Asn Tyr Gly Ile  Ile Ser Pro 
    1295                 1300                 1305             


Asn Leu  Tyr Arg Val Gln Lys  Val Ser Arg Ile Asp  Lys Gly Thr 
    1310                 1315                 1320             


Ser Ala  Ser Arg Asp Tyr Trp  Phe Arg His His Leu  Glu Thr Ile 
    1325                 1330                 1335             


Leu Asn  Asp Asp Ala Lys Leu  Lys Asn Leu Ala Phe  Lys Arg Ile 
    1340                 1345                 1350             


Arg Gly  Leu Leu Glu Leu Lys  Asp Ile Ile Lys Val  Arg Ile Asn 
    1355                 1360                 1365             


Ser Thr  Gly Lys Ile Val Ala  Val Gly Glu Tyr Asp  
    1370                 1375                 1380 


<210> 393
<211> 1425
<212> PRT
<213> Prevotella micans


<220>
<223> Prevotella micans F0438

<400> 393
Met Ile Gln Lys Ile Phe Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly 
1               5                   10                  15      


Ser Ser Val Arg Asn Leu Glu Leu Gly Glu Asn Leu Thr Glu Gln Leu 
            20                  25                  30          


Glu Phe Phe Ser Ser Asp Ile Phe Gly Ser Ser Val Ser Lys Asn Ser 
        35                  40                  45              


Asn Gly Arg Glu Tyr Ser Leu Ala Gly Asn Arg Ser Ala His Arg Arg 
    50                  55                  60                  


Ser Arg Gly Leu Asn Glu Ala Arg Arg Arg Lys Leu Trp Ala Thr Leu 
65                  70                  75                  80  


Asp Leu Leu Ile Glu His Gly Leu Cys Pro Met Ser Pro Asp Ser Leu 
                85                  90                  95      


Met Gln Trp Arg Thr Tyr Asp Lys Gln Lys Gly Leu Tyr Arg Gln Tyr 
            100                 105                 110         


Pro Ile Glu Asp Lys Asp Phe Asn Ala Trp Ile Met Leu Asp Phe Asn 
        115                 120                 125             


Gly Asp Gly Lys Pro Asp Tyr Ser Ser Pro Tyr Gln Leu Arg Arg Glu 
    130                 135                 140                 


Leu Val Val Arg Gln Phe Asp Phe Asp Gln Pro Ile Glu Arg Tyr Lys 
145                 150                 155                 160 


Leu Gly Arg Ala Leu Tyr His Ile Ala Gln His Arg Gly Phe Lys Ser 
                165                 170                 175     


Ser Lys Gly Glu Thr Ile Ala Asp Gln Glu Lys Asn Glu Lys Lys Pro 
            180                 185                 190         


Ile Ala Glu Glu Gly Ala Asp Ile Ala Asn Glu Met Lys Ala Ser Glu 
        195                 200                 205             


Thr Lys Leu Ser Lys Gly Leu Val Ala Tyr Met Gln Glu Asn His Leu 
    210                 215                 220                 


Lys Thr Val Gly Glu Ala Phe Ala Lys Leu Glu Asp Glu Arg Val Arg 
225                 230                 235                 240 


Ile Arg Asn Asn Glu Ser Tyr Arg Ala Ile Arg Ser Gln Tyr Gln Asp 
                245                 250                 255     


Glu Ile Lys Glu Ile Phe Thr Tyr Gln Lys Lys Leu Ser Val Glu Ser 
            260                 265                 270         


Glu Leu Tyr Glu Arg Leu Thr Ser Glu Lys Lys Gly Val Gly Thr Ile 
        275                 280                 285             


Phe Tyr Lys Arg Pro Leu Arg Ser Gln Arg Gly Asn Val Gly Lys Cys 
    290                 295                 300                 


Thr Leu Glu Arg Asn Lys Pro Arg Cys Pro Ile Gly Arg Pro Glu Phe 
305                 310                 315                 320 


Glu Glu Phe Arg Ala Trp Thr Leu Ile Asn Asn Ile Lys Ile Arg Glu 
                325                 330                 335     


Thr Ala Gly Glu Pro Tyr Lys Gln Leu Pro Ile Lys Leu Arg Gln Glu 
            340                 345                 350         


Leu Leu Lys Asp Cys Phe Leu Ser Lys Val Lys Ala Asp Phe Lys Phe 
        355                 360                 365             


Glu Asp Ile Arg Lys Tyr Ile Glu Lys Arg Leu Gly Leu Ser Phe Ser 
    370                 375                 380                 


Asn Asp Asp Lys Thr Ile Asn Tyr Lys Asp Ser Val Ser Ile Ala Ala 
385                 390                 395                 400 


Cys Pro Val Thr Val Arg Met Lys Lys Leu Leu Gly Glu Asn Trp Ala 
                405                 410                 415     


Asn Cys Arg Ile Asp Gly Glu Lys Arg Arg Gln Ala His Gly Lys Asn 
            420                 425                 430         


Asn Asn Asn Glu His Ile Val Ser Tyr Thr Glu Glu Asp Ile Trp His 
        435                 440                 445             


Val Cys Tyr Asn Ala Glu Asp Pro Glu Glu Val Ser Asn Phe Ala Arg 
    450                 455                 460                 


Lys Ala Leu His Trp Asp Glu Asn Lys Ile Lys Glu Leu Val Arg Leu 
465                 470                 475                 480 


Trp Thr Ser Ile Pro Gln Gly Tyr Ala Met Leu Ser Leu Lys Ala Ile 
                485                 490                 495     


Arg Asn Ile Asn Arg Met Leu Leu Leu Gly Leu Lys Tyr Ser Asp Ala 
            500                 505                 510         


Val Leu Leu Ala Lys Leu Pro Asp Ile Val Pro Val Ser Asp Glu Asp 
        515                 520                 525             


Ile Leu Ala Ile Thr Lys Glu Phe Leu Gln Leu Glu Asp Lys Leu Asn 
    530                 535                 540                 


Gln Glu Lys Gln Ile Asn Asn Ile Val Asn Ser Leu Ile Ala Asn Tyr 
545                 550                 555                 560 


Lys Ser Lys Leu Glu Glu Asn Arg Phe Ala Asp His Asn Tyr Gln Tyr 
                565                 570                 575     


Gln Leu Gly Glu Gly Asp Asp Glu Asp Ile Asn Thr Gln Ile Lys Ser 
            580                 585                 590         


His Ile Gly Ala Lys Leu Trp Val Gln Ile Gly Ala Asp Glu Gln Thr 
        595                 600                 605             


Lys Ile Phe Gln Ala Val Arg Ser Lys Tyr Gln Asp Phe Phe Lys Ser 
    610                 615                 620                 


Tyr Lys Arg Lys Phe Val Glu Ser Pro Lys Leu Gly Glu Leu Leu Val 
625                 630                 635                 640 


Ala Phe Leu Thr Glu Lys Phe Pro Asn Val Lys Ser Lys Gln Trp Glu 
                645                 650                 655     


Arg Leu Tyr His Pro Ser Gln Ile Ala Ile Tyr Arg Pro Ile Pro Val 
            660                 665                 670         


Asp Asn Asp Arg Ser Lys Leu Arg Leu Gly Asn Pro Asn Ile Gly Ala 
        675                 680                 685             


Ile Lys Asn Pro Thr Val Met Arg Val Leu Asn Thr Leu Arg Arg Arg 
    690                 695                 700                 


Val Asn Gln Leu Leu Asp Asp Gly Val Ile Ser Pro Asp Glu Thr Arg 
705                 710                 715                 720 


Val Val Val Glu Thr Ala Arg Glu Leu Asn Asp Ala Asn Thr Lys Trp 
                725                 730                 735     


Ala Leu Asp Arg Tyr Asn Arg Ile Arg Arg Asp Glu Asn Glu Lys Ile 
            740                 745                 750         


Arg Lys Ile Leu Lys Glu Leu Asn Pro Thr Thr Asn Ser Ile Ser Glu 
        755                 760                 765             


Gln Asp Ile Asp Lys Ala Arg Tyr Ile Phe Glu Gln Cys Glu Thr Asp 
    770                 775                 780                 


Phe Tyr Thr Asp Gly Lys Val Pro Tyr Tyr Asn Lys Asp Ile Lys Lys 
785                 790                 795                 800 


Tyr Lys Leu Trp Leu Glu Gln Gly Gly Gln Cys Leu Tyr Thr Gly Gln 
                805                 810                 815     


Thr Ile Asn Leu Thr Asn Leu Phe Asn Pro Asn Ala Phe Asp Met Glu 
            820                 825                 830         


His Thr Ile Pro Lys Ser Ile Ser Phe Asp Asn Ser Asp Gln Asn Leu 
        835                 840                 845             


Thr Leu Cys Glu Ser Tyr Tyr Asn Arg Phe Ile Lys Lys Asn Asn Ile 
    850                 855                 860                 


Pro Thr Asp Met Pro Asn Tyr Asp Lys Asp Val Thr Ile Asn Gly Lys 
865                 870                 875                 880 


Glu Tyr Thr Ala Ile Lys Pro Arg Leu Gln Arg Trp Lys Glu Arg Val 
                885                 890                 895     


Asp Arg Leu Ser Arg Asn Val Asp Phe Trp Lys Gly Gln Ala Arg Arg 
            900                 905                 910         


Ala Gln Asp Lys Asp Arg Lys Asp Glu Cys Ile Arg Glu Lys His Leu 
        915                 920                 925             


Trp Asp Met Glu Leu Ala Tyr Trp Lys Gly Lys Leu Glu Arg Phe Thr 
    930                 935                 940                 


Met Thr Asp Val Thr Asp Gly Phe Lys Asn Ser Gln Leu Val Asp Thr 
945                 950                 955                 960 


Arg Val Ile Thr Arg His Ala Val Leu Tyr Leu Lys Ser Ile Phe Asn 
                965                 970                 975     


His Val Glu Val Gln Arg Gly Glu Thr Thr Ala Glu Phe Arg Lys Ile 
            980                 985                 990         


Leu Gly Leu Gln Ser Ile Asp Glu  Lys Lys Asp Arg Ser  Leu His Ser 
        995                 1000                 1005             


His His  Ala Ile Asp Ala Thr  Met Leu Thr Val Ile  Pro Ser Ala 
    1010                 1015                 1020             


Ala Lys  Arg Asp Arg Met Leu  Glu Leu Phe Tyr Lys  Ile Glu Glu 
    1025                 1030                 1035             


Thr Lys  Lys Ala Leu Lys Asn  Tyr Asn Asp Asn Asn  Lys Thr Gly 
    1040                 1045                 1050             


Leu Asn  Leu Glu Leu Lys Gly  Leu Glu Glu Lys Leu  Asp Lys Glu 
    1055                 1060                 1065             


Lys Lys  Asp Cys Arg Val Gly  Arg Arg Val Asn Asp  Leu Asp Arg 
    1070                 1075                 1080             


Phe Ile  Asn Glu Asn Ile Ile  Val Ser His His Thr  Lys Asp Gln 
    1085                 1090                 1095             


Ala Leu  Thr Pro Ala His Arg  Arg Leu Arg Lys Arg  Gly Lys Ile 
    1100                 1105                 1110             


Val Gly  Gly Lys Glu His Pro  Arg Trp Gln Thr Gly  Asp Ser Leu 
    1115                 1120                 1125             


Arg Gly  Glu Ile His Lys Ala  Ser Tyr Tyr Gly Ala  Ile Thr Gln 
    1130                 1135                 1140             


Phe Ala  Lys Asp Ala Asn Gly  Lys Val Leu Met Lys  Asp Gly Gln 
    1145                 1150                 1155             


Ala Gln  Ile Asp Pro Thr Ile  Tyr Tyr Val Ile Arg  Arg Glu Leu 
    1160                 1165                 1170             


Lys Tyr  Lys Arg Ser Thr Gln  Asp Ser Gly Phe Thr  Asn Trp Glu 
    1175                 1180                 1185             


Asp Leu  Glu Lys Val Ile Val  Asp Thr Asp Leu Phe  Gly Leu Met 
    1190                 1195                 1200             


Lys Gly  Gln Phe Pro Glu Gly  Thr Ser Phe Lys Asp  Ala Cys Glu 
    1205                 1210                 1215             


Gln Gly  Phe Tyr Met Ile Lys  Lys Gly Lys Asn Gly  Glu Gly Asp 
    1220                 1225                 1230             


Val Lys  Thr His Arg Ile Arg  His Val Arg Cys Lys  Ala Val Lys 
    1235                 1240                 1245             


Thr Ala  Leu Arg Ile Lys Glu  Gln Thr Tyr Lys Ser  Ser Lys Asp 
    1250                 1255                 1260             


Tyr Lys  Gln Phe Phe Tyr Ala  Ala Val Gly Asp Leu  Tyr Val Met 
    1265                 1270                 1275             


Cys Tyr  Tyr Thr Asp Gly Lys  Lys Arg Asp Phe Lys  Ile Tyr Ser 
    1280                 1285                 1290             


Leu Tyr  Asp Ile Ser Asn His  Arg Lys Ser Gly Thr  Glu Asp Ile 
    1295                 1300                 1305             


Pro Lys  Phe Ile Thr Asp Lys  Lys Gly Asn His Leu  Pro Leu Asp 
    1310                 1315                 1320             


Tyr Lys  Leu Arg Thr Gly Asp  Met Val Leu Leu Tyr  Lys Asp Asn 
    1325                 1330                 1335             


Pro Glu  Glu Leu Lys Asp Leu  Asp Gln Val Asn Leu  Lys Arg Arg 
    1340                 1345                 1350             


Leu Tyr  Lys Val Asn Arg Phe  Glu Ser Glu Gly Leu  Ile Ile Leu 
    1355                 1360                 1365             


Leu Thr  His His Leu Ser Thr  Thr Thr Glu Arg Gly  Cys Ser Ile 
    1370                 1375                 1380             


Gly Lys  Ile Glu Asn Tyr Gln  Asn Leu Pro Thr Ala  Ile Arg Cys 
    1385                 1390                 1395             


Gly Ile  Lys Thr Ile Lys Phe  Leu Ile Met Gly Lys  His Arg Asp 
    1400                 1405                 1410             


Phe Val  Ile Arg Asn Gly Asn  Ile Glu Phe Lys His  
    1415                 1420                 1425 


<210> 394
<211> 1506
<212> PRT
<213> Prevotella nigrescens


<220>
<223> Prevotella nigrescens ATCC 33563

<400> 394
Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Pro Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Lys Val Glu Val Asp Asp Glu Gly Asn Tyr Leu Arg Asn Ile Lys 
            20                  25                  30          


Leu Gly Ser Arg Ile Ile Pro Met Thr Gln Asp Met Leu Gly Asp Phe 
        35                  40                  45              


Asp Lys Gly Val Lys Val Ser Gln Thr Ala Ile Arg Thr Asp Phe Arg 
    50                  55                  60                  


Gly Asn Arg Arg Leu Ile Glu Arg His Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu His Ala Leu Lys Phe Leu Pro Lys His Tyr Glu Asp 
                85                  90                  95      


Ala Ile Gly Trp Asp Arg Asn Glu Pro Ala Thr Tyr Gly Lys Phe Val 
            100                 105                 110         


Asn Asn Ser Glu Pro Lys Leu Ala Trp Glu Arg Gln Glu Asp Gly Ser 
        115                 120                 125             


Met Arg Phe Leu Phe Met Glu Ser Phe Asn Glu Met Val Ala Asp Phe 
    130                 135                 140                 


Ala Gln Asn Gln Pro Ser Leu Val Ser Asp Gly Lys Lys Ile Pro Leu 
145                 150                 155                 160 


Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Arg Pro Ile 
                165                 170                 175     


Lys Lys Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg 
            180                 185                 190         


Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Glu Glu Asp Asn Leu Thr Lys 
        195                 200                 205             


Arg Lys Glu Tyr Tyr Lys Leu Lys Val Val Gly Val Glu Ala Asp Gly 
    210                 215                 220                 


Ala Pro Lys Gly Gly Lys Thr Trp Tyr Asn Ile His Leu Glu Asn Gly 
225                 230                 235                 240 


Trp Thr Ala Arg Cys Gln Ser Lys Ile Pro Leu Asp Asp Trp Val Gly 
                245                 250                 255     


Lys Val Lys Glu Tyr Ile Val Thr Thr Glu Tyr Glu Asp Asp Gly Lys 
            260                 265                 270         


Thr Pro Lys Cys Asp Lys Glu Gly Lys Val Lys Arg Ser Phe Lys Ser 
        275                 280                 285             


Pro Glu Lys Asp Asp Trp Gln Leu Ile Lys Thr Arg Thr Glu Lys Phe 
    290                 295                 300                 


Ile Asp Asp Ser Asn Lys Thr Val Gly Ala Phe Ile Tyr Asp Tyr Leu 
305                 310                 315                 320 


Leu Glu Lys Pro Phe Asp Lys Ile Arg Gly Lys Tyr Ile Arg Thr Ile 
                325                 330                 335     


Glu Arg Lys Tyr Tyr Lys Asn Glu Leu Arg Glu Ile Leu Arg Glu Gln 
            340                 345                 350         


Thr Lys Tyr His Glu Gly Leu His Ser Leu Glu Ala Leu Lys Ile Cys 
        355                 360                 365             


Ala Glu Glu Leu Tyr Lys Asn Asn Gln Gln His Gln Glu Tyr Leu Leu 
    370                 375                 380                 


Lys Lys Asp Met Thr Phe Leu Leu Leu Asn Asp Leu Ile Phe Tyr Gln 
385                 390                 395                 400 


Arg Pro Leu Lys Ser Lys Lys Ser Leu Ile Ala Asp Cys Pro Tyr Glu 
                405                 410                 415     


Val Tyr Lys Tyr Asp Asp Lys Leu Thr Gly Lys Lys Gly Gln Lys Lys 
            420                 425                 430         


Ile Lys Cys Ile Ala Lys Ser Asn Pro Tyr Tyr Gln Glu Phe Arg Leu 
        435                 440                 445             


Trp Gln Phe Ile Ala Asn Leu Arg Leu Phe Ser Val Thr Asp Gly Lys 
    450                 455                 460                 


Glu Val Thr Ala Glu Tyr Leu Lys Thr Glu Glu Asp Tyr Val Arg Leu 
465                 470                 475                 480 


Phe Ser Phe Leu Asn Asp Arg Lys Asp Ile Lys Gln Glu Thr Phe Leu 
                485                 490                 495     


Arg Ser Phe Leu Lys Leu Lys Lys Glu Ser Ile Gly Ser Glu Lys Ile 
            500                 505                 510         


Tyr Pro Ile Arg Trp Asn Tyr Ile Glu Asp Ala Asn Lys Ser Tyr Pro 
        515                 520                 525             


Cys Asn Ala Thr Arg His Glu Leu Leu Leu Ala Phe Asp Arg Ala Asp 
    530                 535                 540                 


Ile Pro Arg Glu Leu Leu Asp Val Glu Glu Arg Glu Tyr Arg Leu Trp 
545                 550                 555                 560 


His Leu Leu Tyr Ser Ile Glu Ala Lys Glu Glu Thr Glu Ser Ala Leu 
                565                 570                 575     


Arg Lys Leu Lys Ala Asn Lys Ala Phe Gly Asp Leu Asn Ile Asp Asp 
            580                 585                 590         


Ala Phe Val Asn Ser Phe Leu Lys Ile Lys Pro Phe Glu Lys Glu Tyr 
        595                 600                 605             


Gly Ala Tyr Ser Glu Lys Ala Ile Lys Lys Leu Leu Ala Val Met Arg 
    610                 615                 620                 


Arg Gly Ser Leu Trp Lys Glu Ala Asp Ile Cys Glu Ala Thr Lys Gln 
625                 630                 635                 640 


Asn Ile Ala Lys Ile Leu Gln Asn Asp Ile Asp Glu Lys Leu Lys Lys 
                645                 650                 655     


Lys Ile Glu Ala Ala Val Ser Ser Phe Asn Lys Leu Ser Asp Phe Gln 
            660                 665                 670         


Gly Leu Pro Thr Trp Leu Ala Cys Tyr Val Val Tyr Gly Arg His Ser 
        675                 680                 685             


Glu Ala Ala Gln Ile Gln Cys Trp Gln Ser Pro Glu Asp Leu Lys Thr 
    690                 695                 700                 


Tyr Ile Asn Lys Phe Lys Gln His Ser Leu Arg Asn Pro Ile Val Glu 
705                 710                 715                 720 


Gln Cys Leu Leu Glu Thr Leu Arg Thr Val Tyr Asp Ile Trp Lys Asp 
                725                 730                 735     


Ala Gly Gln Ile Asp Glu Ile His Ile Glu Leu Gly Arg Asn Met Lys 
            740                 745                 750         


Ser Thr Ala Glu Gln Arg Ala Arg Lys Thr Lys Asp Ile Leu Arg Asn 
        755                 760                 765             


Glu Asn Thr Asn Leu Arg Ile Lys Asn Leu Leu Val Glu Leu Lys Asn 
    770                 775                 780                 


Asp Asp Lys Ile Glu Asn Val Arg Pro Tyr Ser Pro Ser Gln Gln Glu 
785                 790                 795                 800 


Ile Leu Arg Ile Tyr Glu Glu Gly Ala Leu Gln Glu Leu Ser Lys Glu 
                805                 810                 815     


Asp Glu Met Phe Glu Asp Ile Ser Lys Ile Ser Lys Met Ala Gln Pro 
            820                 825                 830         


Ser Pro Thr Glu Leu Ser Arg Tyr Lys Leu Trp Leu Glu Gln Lys Tyr 
        835                 840                 845             


Arg Ser Pro Tyr Thr Gly Arg Val Ile Pro Leu Ser Lys Leu Phe Thr 
    850                 855                 860                 


Thr Ala Tyr Gln Ile Glu His Ile Ile Pro Gln Ser Arg Tyr Phe Asp 
865                 870                 875                 880 


Asp Ser Phe Asn Asn Lys Val Ile Cys Glu Ser Glu Val Asn Ser Leu 
                885                 890                 895     


Lys Asp Asn Met Leu Gly Tyr Glu Phe Ile Lys Glu Cys Gly Gly Arg 
            900                 905                 910         


Ile Val His Cys Thr Leu Leu Gly Asp Val Lys Ile Phe Thr Lys Glu 
        915                 920                 925             


Glu Tyr Lys Asp Phe Val Thr Lys His Tyr Ile Asp Asn Thr Tyr Lys 
    930                 935                 940                 


Arg Asp Lys Leu Leu Leu Glu Asp Ile Pro Gln Glu Phe Ser Ala Arg 
945                 950                 955                 960 


Gln Leu Asn Asp Ser Arg Tyr Ile Ser Lys Met Val Gln Thr Val Leu 
                965                 970                 975     


Ser Asn Ile Val Arg Ala Glu Asn Glu Gln Glu Ala Thr Ser Lys Phe 
            980                 985                 990         


Val Val Ser Cys Asn Gly Ala Ile  Thr Asn Arg Leu Lys  Lys Asp Trp 
        995                 1000                 1005             


Gly Leu  Asn Asp Val Trp Ser  Ser Ile Val Cys Pro  Arg Phe Lys 
    1010                 1015                 1020             


Arg Leu  Asn Glu Ile Thr Lys  Thr Asn Ala Phe Gly  His Trp Glu 
    1025                 1030                 1035             


Asp Lys  Ala Gly Lys His Val  Phe Gln Thr Thr Val  Pro Leu Glu 
    1040                 1045                 1050             


Leu Gln  Arg Gly Phe Ser Lys  Lys Arg Ile Asp His  Arg His His 
    1055                 1060                 1065             


Ala Met  Asp Ala Leu Val Ile  Ala Cys Ala Ser Arg  Asn Ile Val 
    1070                 1075                 1080             


Asn Tyr  Leu Asn Asn Glu Ser  Ala Asn Ser Pro Glu  Lys Arg Glu 
    1085                 1090                 1095             


Asp Leu  Arg Lys Lys Leu Cys  Asp Glu Lys Arg Lys  Ile Arg Lys 
    1100                 1105                 1110             


Pro Trp  Lys Thr Phe Thr Gln  Asp Ala Arg Glu Ala  Leu Ser Asp 
    1115                 1120                 1125             


Val Val  Val Ser Phe Lys Asn  Tyr Val Arg Val Ile  Asn Lys Ala 
    1130                 1135                 1140             


Thr Asn  Tyr Tyr Glu His Tyr  Ser Ser Ser Gly Asn  Lys Val Met 
    1145                 1150                 1155             


Ile Ser  Gln Lys Gly Asn Asp  Met Trp Ala Ile Arg  Lys Pro Leu 
    1160                 1165                 1170             


His Lys  Glu Ser Val Phe Gly  Arg Val Asn Leu Cys  Arg Lys Val 
    1175                 1180                 1185             


Ile Val  Ser Leu Lys Lys Ala  Leu Glu Asn Ile Pro  Ala Ile Cys 
    1190                 1195                 1200             


Asp Lys  Thr Leu Arg Asp Tyr  Ile Asn Ala Leu Val  Glu Lys His 
    1205                 1210                 1215             


Phe Asn  Thr Arg Gln Leu Leu  Ala His Phe Lys Ser  Ile Asn Tyr 
    1220                 1225                 1230             


Arg Leu  Asn Arg Gln Cys Val  Glu Lys Val Glu Val  Trp Gln Phe 
    1235                 1240                 1245             


Ser Asp  Glu Lys Ile Glu Met  Val Ala Arg Arg Lys  Ser Leu Asp 
    1250                 1255                 1260             


Thr Ser  Phe Asp Asp Lys Gln  Ile Ser Ser Ile Thr  Asp Thr Gly 
    1265                 1270                 1275             


Ile Gln  Lys Ile Leu Leu Asn  Tyr Leu Gln Thr Lys  Asp Gly Asn 
    1280                 1285                 1290             


Ala Glu  Ile Ala Phe Thr Pro  Glu Gly Ile Glu Glu  Met Asn Lys 
    1295                 1300                 1305             


Asn Ile  Ser Leu Tyr Asn Asp  Gly Lys Ala His Gln  Pro Ile Leu 
    1310                 1315                 1320             


Lys Val  Arg Val Ala Thr Pro  Lys Gly Met Lys Tyr  Pro Val Gly 
    1325                 1330                 1335             


Gln Thr  Gly Asn Lys Ala Thr  Lys Phe Val Val Ala  Glu Lys Gly 
    1340                 1345                 1350             


Thr Asn  Leu Tyr Phe Ala Ile  Tyr Glu Asn Glu Leu  Gly Val Arg 
    1355                 1360                 1365             


Ser Tyr  Asp Thr Ile Pro Leu  Asn Ile Val Val Glu  Arg Leu Lys 
    1370                 1375                 1380             


Glu Gly  Leu Ser Pro Val Pro  Gln Ala Asn Glu Ala  Asp Ile Pro 
    1385                 1390                 1395             


Leu Lys  Phe Tyr Leu Ser Pro  Asn Asp Leu Val Tyr  Val Pro Thr 
    1400                 1405                 1410             


Lys Glu  Asn Glu Asp Glu Leu  Cys Arg Asp Arg Ile  Tyr Lys Phe 
    1415                 1420                 1425             


Val Asp  Ser Ser Gly Thr Thr  Ala Asn Phe Val Pro  His Thr Ser 
    1430                 1435                 1440             


Ala Asn  Thr Ile Tyr Asn Val  Asp Lys Glu Tyr Ala  Glu Lys Cys 
    1445                 1450                 1455             


Cys Asn  Gly Ala Val Phe Leu  Asn Glu Tyr Gly Leu  Gly Ser Pro 
    1460                 1465                 1470             


Gln Ser  Lys Asn Gln Arg Ala  Leu Thr Gly Glu Met  Ile Lys Glu 
    1475                 1480                 1485             


Ile Cys  Trp Lys Leu Lys Val  Asp Arg Leu Gly Asn  Ile Ile Lys 
    1490                 1495                 1500             


Val Ile  Lys 
    1505     


<210> 395
<211> 1380
<212> PRT
<213> Prevotella nigrescens


<220>
<223> Prevotella nigrescens F0103

<400> 395
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Glu Ser Asn Asn Glu Ala Ser Ser Ile Val 
            20                  25                  30          


Arg Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Lys Ser Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ala Ile Thr Thr Asn Ala Asp Arg Gln Leu Arg 
    50                  55                  60                  


His Gly Ala Arg Ile Asn Leu Gln Arg Tyr Lys Leu Arg Arg Gln Asn 
65                  70                  75                  80  


Leu His Asp Cys Leu Gln Lys Gln Gly Trp Leu Gly Thr Glu Ala Met 
                85                  90                  95      


Tyr Glu Glu Gly Lys Ala Ser Thr Phe Glu Thr Tyr Lys Leu Arg Ala 
            100                 105                 110         


Lys Ala Ala Glu Glu Glu Ile Ser Leu His Glu Phe Ala Arg Val Leu 
        115                 120                 125             


Phe Met Leu Asn Lys Lys Arg Gly Tyr Lys Ser Asn Arg Lys Ala Asn 
    130                 135                 140                 


Asn Lys Glu Asp Gly Gln Leu Phe Asp Gly Met Thr Ile Ala Lys Lys 
145                 150                 155                 160 


Leu Tyr Glu Glu His Leu Thr Pro Ala Glu Tyr Ser Leu Gln Leu Leu 
                165                 170                 175     


Asn Lys Gly Lys Lys Phe Thr Gln Gly Tyr Tyr Arg Ser Asp Leu Asn 
            180                 185                 190         


Ala Glu Leu Glu Arg Ile Trp Asp Glu Gln Lys Lys Tyr Tyr Pro Glu 
        195                 200                 205             


Ile Leu Thr Asp Glu Phe Lys Gln Gln Leu Glu Gly Lys Thr Lys Thr 
    210                 215                 220                 


Asn Thr Ser Lys Ile Phe Leu Ala Lys Tyr Gly Ile Tyr Ser Ala Asp 
225                 230                 235                 240 


Leu Lys Gly Leu Asp Arg Lys Leu Gln Pro Leu Lys Trp Arg Val Glu 
                245                 250                 255     


Ala Leu Lys Gln Gln Val Asp Lys Glu Val Leu Ala Phe Val Ile Ser 
            260                 265                 270         


Asp Leu Lys Gly Gln Ile Ala Asn Thr Ser Gly Leu Leu Gly Ala Ile 
        275                 280                 285             


Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Lys Gln Thr Val Gly Gln 
    290                 295                 300                 


Tyr Leu Trp Ala Ser Leu Glu Glu Asn Pro His Ile Ser Ile Lys Asn 
305                 310                 315                 320 


Lys Pro Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu Lys Ile Trp 
                325                 330                 335     


Glu Thr Gln Ala Thr Phe His Lys Gln Leu Thr Pro Glu Leu Lys Gln 
            340                 345                 350         


Glu Ile Arg Asp Ile Ile Ile Phe Tyr Gln Arg Pro Leu Lys Ser Lys 
        355                 360                 365             


Lys Ser Leu Ile Ser Val Cys Glu Leu Glu Gln Arg Lys Val Lys Ala 
    370                 375                 380                 


Thr Ile Asp Gly Lys Glu Lys Glu Ile Thr Ile Gly Pro Lys Val Ala 
385                 390                 395                 400 


Pro Lys Ser Ser Pro Val Phe Gln Glu Phe Arg Ile Trp Gln Asn Leu 
                405                 410                 415     


Asn Asn Val Leu Leu Ile Asp Asn Asp Thr Asn Glu Lys Arg Pro Leu 
            420                 425                 430         


Asp Glu Asp Glu Arg Tyr Leu Leu Tyr Lys Glu Leu Ser Ile Lys Ala 
        435                 440                 445             


Lys Leu Ser Lys Thr Glu Ala Leu Lys Ile Leu Asn Lys Lys Gly Lys 
    450                 455                 460                 


Gln Trp Asp Leu Asn Tyr Lys Glu Leu Glu Gly Asn Arg Thr Gln Ala 
465                 470                 475                 480 


Ile Leu Phe Asp Cys Tyr Asn Arg Ile Ile Thr Leu Thr Gly His Glu 
                485                 490                 495     


Glu Cys Asp Phe Lys Lys Ile Lys Ala Ser Glu Ile Arg His Tyr Val 
            500                 505                 510         


Ser Thr Ile Phe Lys Asn Leu Gly Phe Ser Thr Glu Ile Leu Asp Phe 
        515                 520                 525             


Asp Pro Ser Leu Glu Lys His Glu Leu Glu Lys Gln Pro Met Tyr Gln 
    530                 535                 540                 


Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asn Ser Arg Thr Gly 
545                 550                 555                 560 


Asn Glu Ser Leu Leu Arg Lys Leu Glu Thr Thr Phe Gly Phe Pro Glu 
                565                 570                 575     


Glu Tyr Ala Thr Val Leu Cys Asp Val Val Phe Glu Glu Asp Tyr Gly 
            580                 585                 590         


Asn Leu Ser Val Lys Ala Met Arg Lys Ile Leu Pro Tyr Leu Gln Ala 
        595                 600                 605             


Gly Asn Asp Tyr Ser Gln Ala Cys Ala Tyr Ala Gly Tyr Asn His Ser 
    610                 615                 620                 


Arg His Ser Leu Thr Lys Glu Glu Leu Asp Gln Lys Val Tyr Lys Glu 
625                 630                 635                 640 


Arg Leu Glu Leu Leu Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu 
                645                 650                 655     


Lys Ile Leu Asn Gln Met Ile Asn Val Ile Asn Ala Ile Ile Asp Glu 
            660                 665                 670         


Tyr Gly Lys Pro Asp Glu Ile Arg Ile Glu Met Ala Arg Glu Leu Lys 
        675                 680                 685             


Ser Ser Ala Ala Asp Arg Lys Lys Thr Thr His Ala Ile Asn Gln Gly 
    690                 695                 700                 


Asn Asp Glu Asn Gln Cys Ile Arg Glu Ile Leu Glu Lys Glu Phe Ala 
705                 710                 715                 720 


Leu Ser Tyr Ile Ser Arg Asn Asp Ile Ile Lys Tyr Lys Leu Tyr Glu 
                725                 730                 735     


Glu Leu Lys Pro Asn Gly Phe Lys Thr Leu Tyr Ser Asp Thr Tyr Ile 
            740                 745                 750         


Pro Lys Asp Lys Leu Phe Ser Lys Asp Phe Asp Ile Glu His Ile Ile 
        755                 760                 765             


Pro Lys Ala Arg Leu Phe Asp Asp Ser Tyr Ser Asn Lys Thr Leu Glu 
    770                 775                 780                 


Ala Arg Asp Ile Asn Leu Ala Lys Ser Asn Lys Thr Ala Phe Asp Phe 
785                 790                 795                 800 


Val Lys Glu Lys Tyr Gly Glu Gln Gly Ala Glu Ala Tyr Lys Lys Lys 
                805                 810                 815     


Leu Asp Met Leu Leu Gly Asn Asn Val Ile Ser Lys Pro Lys Tyr Asn 
            820                 825                 830         


Lys Leu Leu Met Thr Glu Ala Asp Ile Pro Ser Asp Phe Ile Asn Arg 
        835                 840                 845             


Asp Leu Arg Asn Thr Gln Tyr Ile Ala Arg Lys Ala Cys Glu Ile Leu 
    850                 855                 860                 


Gly Glu Leu Val Arg Thr Val Thr Pro Thr Thr Gly Lys Ile Thr Asn 
865                 870                 875                 880 


Arg Leu Arg Glu Asp Trp Gln Leu Val Asp Val Met Lys Glu Leu Asn 
                885                 890                 895     


Phe Glu Lys Tyr Glu Lys Leu Gly Leu Thr Glu Ile Val Glu Asp Arg 
            900                 905                 910         


Asp Gly Arg Lys Ile Lys Arg Ile Lys Asp Trp Thr Lys Arg Asn Asp 
        915                 920                 925             


His Arg His His Ala Met Asp Ala Leu Ala Ile Ala Phe Thr Lys Pro 
    930                 935                 940                 


Ser Tyr Ile Gln Tyr Leu Asn Asn Leu Asn Ala Arg Ser Asn Lys Gly 
945                 950                 955                 960 


Asp Ser Ile Tyr Ala Ile Glu Asn Lys Glu Leu His Tyr Glu Glu Gly 
                965                 970                 975     


Lys Leu Arg Phe Asn Ala Pro Ile Pro Val Asn Val Phe Arg Ala Glu 
            980                 985                 990         


Ala Lys Arg His Leu Ser Ala Ile  Leu Val Ser Ile Lys  Ala Lys Asn 
        995                 1000                 1005             


Lys Val  Met Thr Gln Asn Val  Asn Lys Ile Lys Thr  Lys His Gly 
    1010                 1015                 1020             


Ile Ile  Lys Lys Ile Gln Leu  Thr Pro Arg Gly Pro  Leu His Asn 
    1025                 1030                 1035             


Glu Thr  Ile Tyr Gly Thr Lys  Met Arg Pro Ile Ile  Lys Lys Val 
    1040                 1045                 1050             


Lys Val  Gly Ala Ala Leu Asp  Glu Ala Thr Ile Asn  Lys Val Ser 
    1055                 1060                 1065             


Ser Pro  Ala Ile Arg Glu Val  Leu Leu Lys Arg Leu  Asn Glu Tyr 
    1070                 1075                 1080             


Ser Gly  Asn Ala Lys Lys Ala  Phe Thr Gly Lys Asn  Thr Leu Asp 
    1085                 1090                 1095             


Lys Asn  Pro Ile Tyr Leu Asn  Ala Glu Arg Thr Lys  Thr Val Pro 
    1100                 1105                 1110             


Ala Ser  Val Lys Thr Val Glu  Trp Glu Asn Tyr His  Pro Ile Arg 
    1115                 1120                 1125             


Lys Pro  Ile Thr Pro Asp Leu  Lys Val Asp Lys Val  Ile Asp Lys 
    1130                 1135                 1140             


Gly Ile  Gly Glu Ile Leu Lys  Ala Arg Leu Glu Glu  Phe Asn Gly 
    1145                 1150                 1155             


Asp Ala  Lys Lys Ala Phe Ser  Asn Leu Glu Glu Asn  Pro Ile Tyr 
    1160                 1165                 1170             


Leu Asp  Gln Thr Lys Lys Ile  Ala Leu Lys Arg Val  Ser Ile Glu 
    1175                 1180                 1185             


Gly Val  Leu Ser Thr Ile Pro  Leu His Thr Leu Lys  Asn Gln Ala 
    1190                 1195                 1200             


Gly Lys  Pro Ile Met Gly Lys  Asp Gly Lys Pro Val  Leu Gly Asn 
    1205                 1210                 1215             


Tyr Val  Gln Thr Ser Asn Asn  His His Ile Ala Phe  Tyr Tyr Asp 
    1220                 1225                 1230             


Glu Asp  Gly Asn Leu Gln Asp  Asn Ala Val Ser Phe  Phe Glu Ala 
    1235                 1240                 1245             


Ala Glu  Arg Lys Ser Gln Gly  Ile Ser Val Ile Asp  Lys Asp Tyr 
    1250                 1255                 1260             


Asn Arg  Asp Lys Gly Trp Arg  Phe Leu Phe Thr Met  Lys Gln Asn 
    1265                 1270                 1275             


Glu Tyr  Phe Val Phe Pro Asn  Glu Ala Thr Gly Phe  Ile Pro Ser 
    1280                 1285                 1290             


Glu Val  Asp Leu Thr Asp Glu  Ala Asn Tyr Gly Ile  Ile Ser Pro 
    1295                 1300                 1305             


Asn Leu  Tyr Arg Val Gln Lys  Met Ser Arg Ile Glu  Lys Gly Thr 
    1310                 1315                 1320             


Ser Val  Ser Arg Asp Tyr Trp  Phe Arg His His Leu  Glu Thr Ile 
    1325                 1330                 1335             


Leu Asn  Asp Asp Ser Arg Leu  Lys Asn Ser Ala Phe  Lys Arg Ile 
    1340                 1345                 1350             


Asn Ser  Leu Lys Pro Leu Glu  Gly Ile Ile Lys Val  Arg Ile Asn 
    1355                 1360                 1365             


Ser Ile  Gly Lys Ile Val Ala  Val Gly Glu Tyr Asp  
    1370                 1375                 1380 


<210> 396
<211> 1391
<212> PRT
<213> Prevotella oralis


<220>
<223> Prevotella oralis ATCC 33269

<400> 396
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Lys Glu Asn Asn Glu Glu Leu Ser Ser Ile Ile 
            20                  25                  30          


Arg Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Lys Ser Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Asp Ile Thr Thr Asn Ala Asp Arg Thr Lys Cys 
    50                  55                  60                  


Arg Ser Ala Arg Arg Asn Leu Gln Arg Phe Lys Leu Arg Arg Glu Ala 
65                  70                  75                  80  


Leu Ala Asp Cys Leu Lys Arg His Gly Leu Met Thr Asp Glu Thr Pro 
                85                  90                  95      


Leu Cys Glu Thr Asn Asn Ser Ile Ile Phe Lys Thr Tyr Ser Asn Arg 
            100                 105                 110         


Ala Lys Ala Val Cys Glu Lys Ile Ala Leu Asp Asp Phe Val Arg Val 
        115                 120                 125             


Leu Phe Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Leu 
    130                 135                 140                 


Asn Thr Asp Asp Glu Gly Thr Leu Val Asp Gly Met Asp Val Ala Lys 
145                 150                 155                 160 


Leu Leu Tyr Asn Glu Gln Ile Thr Pro Gly Glu Tyr Leu Leu Arg Leu 
                165                 170                 175     


Phe Lys Lys Gly Lys Lys Thr Arg Pro Asp Phe Tyr Leu Ser Asp Leu 
            180                 185                 190         


Lys Ala Glu Leu Glu Arg Ile Trp Asp Phe Gln Arg Thr Phe Tyr Pro 
        195                 200                 205             


Glu Ile Leu Cys Asn Ala Leu Lys Glu Asp Leu Lys Gly Lys Ser Arg 
    210                 215                 220                 


Thr Gln Ser Ser Ala Ile Phe Tyr Ala Lys Tyr Lys Val Ser Thr Ala 
225                 230                 235                 240 


Lys Ile Ala Gly Lys Asp Lys Arg Leu Gln Glu Leu Thr Trp Arg Thr 
                245                 250                 255     


Asp Ala Leu Arg Lys Gln Leu Thr Ile Asp Glu Val Ala Tyr Val Ile 
            260                 265                 270         


Cys Ser Ile Asn Gly Glu Val Asn Gly Ser Ser Gln Arg Leu Ser Met 
        275                 280                 285             


Ile Ser Asp Arg Ser Lys Leu Leu Tyr Phe Asn His Gln Thr Ile Gly 
    290                 295                 300                 


Gln Tyr Leu Met Gln Arg Leu Glu Glu Asn Pro Asn Ala Gly Leu Lys 
305                 310                 315                 320 


Asn Ile Ile Phe Tyr Arg Gln Asp Tyr Glu Asp Glu Phe Asn Asp Ile 
                325                 330                 335     


Trp Asn Ser Gln Ala Thr Tyr His Lys Glu Leu Thr Pro Glu Leu Lys 
            340                 345                 350         


Lys Glu Val Lys Asp Ile Ile Phe Tyr Gln Arg Gly Leu Lys Ser Cys 
        355                 360                 365             


Lys Trp Leu Ile Asn Tyr Cys Glu Leu Glu His Glu Glu Ile Glu Val 
    370                 375                 380                 


Lys Thr Pro Glu Gly Lys Leu Arg Lys Ile Thr Ile Gly Ser Lys Thr 
385                 390                 395                 400 


Cys Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln Val 
                405                 410                 415     


Leu Asn Asn Leu Gln Val Ser Pro Leu Asn Ser Arg Arg Lys Ala Lys 
            420                 425                 430         


Arg Lys Lys Asp Glu Glu Pro Ser Leu Phe Ser Asp Glu Asp Met Asn 
        435                 440                 445             


Thr Ala Cys Arg Tyr Leu Asn Glu Glu Glu Lys Leu Thr Leu Phe Lys 
    450                 455                 460                 


Glu Leu Ser Ile Lys Lys Glu Leu Lys Lys Lys Asp Ala Leu Lys Leu 
465                 470                 475                 480 


Leu Phe Glu Asn Tyr Lys Glu Leu Asp Leu Asn Tyr Lys Val Ile Ser 
                485                 490                 495     


Gly Asn Val Thr Met Ala Asn Leu Tyr Arg Ala Phe Gln Asp Ile Ile 
            500                 505                 510         


Ser Leu Thr Gly Asn Gly Glu Phe Asp Phe Gln Ala Met Pro Ala Glu 
        515                 520                 525             


Glu Ala Glu Lys Thr Val Glu Glu Ile Phe Gly Gly Leu Gly Tyr Lys 
    530                 535                 540                 


Thr Ala Phe Leu His Phe Asp Ala Ser Leu His Asp Lys Glu Phe Glu 
545                 550                 555                 560 


Arg Gln Pro Ala Tyr Arg Leu Trp His Leu Leu Tyr Ser Tyr Ala Gly 
                565                 570                 575     


Asp Gln Ser Lys Thr Gly Ile Glu Ala Leu Val Lys Arg Ile Gln Glu 
            580                 585                 590         


Leu Cys Gly Phe Glu Pro Glu Tyr Ala Arg Ile Leu Ala Asn Ile Ser 
        595                 600                 605             


Phe Ile Pro Asp Tyr Gly Asn Leu Ser Ser Lys Ala Met Arg Lys Ile 
    610                 615                 620                 


Leu Pro Tyr Met Gln Asp Gly Tyr Glu Tyr Ser Glu Ala Cys Ser Lys 
625                 630                 635                 640 


Ala Gly Tyr Arg His Ser Ala Ser Ser Leu Thr Lys Glu Glu Ile Asn 
                645                 650                 655     


Lys Lys Asn Tyr Lys Thr His Leu Asp Glu Ile Lys Arg Asn Ser Leu 
            660                 665                 670         


Arg Asn Pro Ile Val Glu Lys Ile Leu Asn Gln Met Val Asn Val Val 
        675                 680                 685             


Asn Ser Val Ile Asp Thr Tyr Ser Asn Ile Asp Glu Ile Arg Ile Glu 
    690                 695                 700                 


Met Ala Arg Glu Leu Lys Lys Ser Lys Pro Glu Arg Glu Asp Met Ser 
705                 710                 715                 720 


Phe Ala Ile Ser Lys Ala Thr Lys Glu Thr Glu Arg Ile Lys Gly Ile 
                725                 730                 735     


Leu Glu Gln Glu Phe Lys Ile Gln His Val Thr Arg Asn Asp Ile Ile 
            740                 745                 750         


Arg Tyr Arg Leu Tyr Glu Glu Leu Lys Pro Asn Gly Tyr Lys Thr Leu 
        755                 760                 765             


Tyr Ser Asn Thr Tyr Ile Pro Arg Glu Asp Leu Phe Ser Lys Lys Phe 
    770                 775                 780                 


Asp Ile Glu His Ile Ile Pro Lys Ala Arg Leu Phe Asp Asp Ser Tyr 
785                 790                 795                 800 


Ser Asn Lys Thr Leu Glu Leu Arg Asp Ile Asn Ile Glu Lys Gly Asn 
                805                 810                 815     


Gln Thr Ala Tyr Asp Phe Val Leu Ser Lys Tyr Gly Glu Glu Gly Leu 
            820                 825                 830         


Tyr Lys Tyr Glu Gln Arg Val Glu Glu Phe Lys Lys Asn Asn Glu Gln 
        835                 840                 845             


Ala Gly Thr Lys Cys Arg Lys Leu Leu Met Arg Glu Ala Asp Ile Pro 
    850                 855                 860                 


Ser Asp Phe Leu Asn Arg Asp Leu Asn Asp Ser Gln Tyr Ile Ala Lys 
865                 870                 875                 880 


Lys Ala His Glu Leu Leu Arg Glu Ile Val Pro Thr Val Thr Ala Thr 
                885                 890                 895     


Thr Gly Ser Ile Thr Asn Arg Leu Arg Glu Asp Trp Lys Leu Val Asn 
            900                 905                 910         


Val Met Lys Glu Leu Asn Trp Glu Lys Tyr Asp Lys Leu Gly Leu Thr 
        915                 920                 925             


Glu Glu Tyr Lys Asp Lys Asp Gly Asn Thr Val Arg His Ile Lys Asp 
    930                 935                 940                 


Trp Thr Lys Arg Asn Asp His Arg His His Ala Met Asp Ala Leu Thr 
945                 950                 955                 960 


Ile Ala Phe Thr Lys Pro Ser Phe Ile Gln Tyr Leu Asn Asn Leu Asn 
                965                 970                 975     


Ala Arg Ser Asn Arg Gly Gly Ser Ile Tyr Gly Ile Glu Gln Lys Glu 
            980                 985                 990         


Leu Glu Arg Glu Asn Asn Lys Leu  Val Phe Ile Pro Pro  Ile Asp Pro 
        995                 1000                 1005             


Lys Ile  Phe Arg Lys Gln Ala  Lys Glu His Leu Ser  Asn Ile Leu 
    1010                 1015                 1020             


Ile Ser  Ile Lys Ala Lys Asn  Lys Val Val Thr Lys  Asn Val Asn 
    1025                 1030                 1035             


Lys Thr  Lys Ser Lys Ser Gly  Thr Asn Arg Lys Val  Gln Leu Thr 
    1040                 1045                 1050             


Pro Arg  Gly Gln Leu His Leu  Glu Thr Val Tyr Gly  Lys Ile Arg 
    1055                 1060                 1065             


Thr Tyr  Lys Thr Glu Glu Ile  Lys Val Gly Thr Lys  Leu Thr Glu 
    1070                 1075                 1080             


Glu Leu  Ile Ala Lys Val Ala  Asp Lys Lys Ile Arg  Glu Ala Leu 
    1085                 1090                 1095             


Met Gln  Arg Leu Ser Glu Tyr  Gly Gly Asn Ile Lys  Lys Ala Phe 
    1100                 1105                 1110             


Gln Asn  Ile Ser Lys His Pro  Ile Trp Leu Asn Gly  Ser His Thr 
    1115                 1120                 1125             


Lys His  Val Pro Glu Lys Val  Lys Ile Val Phe Phe  Glu Asp Val 
    1130                 1135                 1140             


Phe Thr  Ile Arg Lys Ala Ile  Thr Pro Asp Ile Lys  Ile Asp Lys 
    1145                 1150                 1155             


Val Ile  Asp Ser Lys Ile Arg  Arg Ile Leu Gln Glu  Arg Leu Asn 
    1160                 1165                 1170             


Glu Phe  Gly Gly Glu Ala Ser  Lys Ala Phe Ser Asn  Leu Asp Glu 
    1175                 1180                 1185             


Asn Pro  Ile Trp Phe Asn Arg  Asp Lys Gly Ile Ala  Ile Lys Ser 
    1190                 1195                 1200             


Val Lys  Ile Arg Gly Ile Ala  Lys Gly Thr Ala Ile  Arg Val Lys 
    1205                 1210                 1215             


Lys Asp  Ile His Gly Lys Thr  Ile Ile Gly Asn Asn  Gly Tyr Pro 
    1220                 1225                 1230             


Val Ala  Asn Asp Tyr Val Asn  Thr Gly Asn Asn His  His Val Ala 
    1235                 1240                 1245             


Ile Phe  Arg Asp Lys Asp Gly  Asn Leu Gln Glu His  Ile Val Ser 
    1250                 1255                 1260             


Phe Tyr  Glu Ala Thr Ala Arg  Ala Ile Gln Asn Leu  Pro Ile Val 
    1265                 1270                 1275             


Asp Arg  Asn Tyr Asn Ser Glu  Lys Asp Trp Lys Phe  Leu Phe Ser 
    1280                 1285                 1290             


Met Lys  Gln Asn Glu Tyr Phe  Val Phe Pro Asn Pro  Asn Thr Gly 
    1295                 1300                 1305             


Phe Asn  Pro Ser Glu Ile Ser  Leu Lys Asp Glu Lys  Asn Tyr Ala 
    1310                 1315                 1320             


Leu Ile  Ser Pro Asn Leu Phe  Arg Val Gln Lys Leu  Ser His Tyr 
    1325                 1330                 1335             


Tyr Tyr  Val Phe Arg His His  Leu Glu Thr Asn Val  Asp Thr Asn 
    1340                 1345                 1350             


Leu Gln  Leu Lys Asp Ile Thr  Trp Lys Arg Ile Thr  Ala Val Asn 
    1355                 1360                 1365             


Asn Leu  Thr Gly Ala Val Lys  Val Arg Ile Asp His  Leu Gly Arg 
    1370                 1375                 1380             


Ile Val  Asp Val Gly Glu Tyr  Lys 
    1385                 1390     


<210> 397
<211> 1204
<212> PRT
<213> Prevotella ruminicola

<400> 397
Met Glu Arg Ile Leu Gly Ile Asp Thr Gly Thr Asn Ser Leu Gly Trp 
1               5                   10                  15      


Ala Ile Val Asp Lys Asp Glu Asn Gln Tyr His Leu Val Ala Lys Gly 
            20                  25                  30          


Thr Asn Ile Phe Ser Glu Gly Val Lys Ile Glu Lys Gly Ile Glu Ser 
        35                  40                  45              


Ser Lys Ala Ala Glu Arg Thr Glu His Arg Ser Val Arg Lys His Tyr 
    50                  55                  60                  


Trp Arg Arg Lys Ile Arg Lys Ile Arg Leu Leu Thr Ile Leu Ser Asp 
65                  70                  75                  80  


Asn Asp Leu Cys Pro Arg Leu Lys His Glu Gln Leu Arg Gln Trp Arg 
                85                  90                  95      


Leu Lys Lys Val Tyr Pro Thr Asp Asp Thr Phe Met Glu Trp Gln Arg 
            100                 105                 110         


Thr Glu Asp Lys Ala Gln Val Asn Pro Tyr Lys Phe Arg Tyr Ile Cys 
        115                 120                 125             


Leu Thr Gln Lys Leu Asp Leu Ser Asp Ile Thr Gln Arg Phe Ile Leu 
    130                 135                 140                 


Gly Arg Ala Leu Tyr His Leu Asn Gln Arg Arg Gly Phe Leu Ser Asn 
145                 150                 155                 160 


Arg Lys Glu Ala Thr Lys Glu Ser Glu Gly Thr Val Lys Glu Gly Ile 
                165                 170                 175     


Ser Ser Leu Ser Lys Asp Met Lys Asp Ser Gly Cys Glu Tyr Leu Gly 
            180                 185                 190         


Glu Tyr Phe Tyr Gln Leu Tyr Gln Gln Gly Lys Lys Ile Arg Asn His 
        195                 200                 205             


Tyr Thr Ala Arg Lys Glu His Tyr Leu Lys Glu Phe Lys Ala Ile Cys 
    210                 215                 220                 


Ser Lys Gln Glu Leu Asp Asp Ala Leu Ile Glu Lys Leu Glu Lys Ala 
225                 230                 235                 240 


Ile Phe Asp Gln Arg Pro Leu Lys Ser Gln Lys Gly Gln Val Gly Thr 
                245                 250                 255     


Cys Thr Phe Glu Lys Gly Lys Ser Arg Cys Pro Ser Ser His Pro Leu 
            260                 265                 270         


Tyr Glu Asp Phe Arg Met Tyr Ser Phe Ile Asn Asn Ile Lys Val Gln 
        275                 280                 285             


Val Asp Thr Leu Tyr Asp Lys Gly Glu Arg Ser Leu Thr Asp Glu Glu 
    290                 295                 300                 


Lys Gln Leu Ile Ile Pro Leu Phe Lys Arg Lys Ser Lys Arg Thr Phe 
305                 310                 315                 320 


Pro Phe Glu Asp Ile Ala Lys Lys Ile Ala Gly Lys Asn Asn Tyr Cys 
                325                 330                 335     


Tyr Ile Lys Ser Asn Glu Glu Lys Ala Tyr Lys Phe Asn Tyr Gln Met 
            340                 345                 350         


Asp Thr Gln Val Ser Gly Ser Pro Val Asn Ala Gln Leu Glu Glu Ile 
        355                 360                 365             


Phe Gly Glu Asp Trp Leu Ser Ser Val Cys Glu Val Tyr Thr Leu Ala 
    370                 375                 380                 


Asn Asn Lys Ser Arg Phe Gln Ile Met Asn Asp Val Trp His Val Leu 
385                 390                 395                 400 


Phe Phe Tyr Asp Asp Glu Asp Lys Leu Lys Glu Phe Ala Lys Asp Arg 
                405                 410                 415     


Leu Gln Leu Asp Asp Glu Leu Ala Glu Lys Phe Ser Lys Ile Ser Ile 
            420                 425                 430         


Pro Asn Asp Tyr Ala Ala Leu Ser Leu Lys Ala Ile Arg Lys Ile Met 
        435                 440                 445             


Pro Tyr Leu Arg Asp Tyr Gly Leu Ile Tyr Ser Glu Ala Val Phe Leu 
    450                 455                 460                 


Ala Asn Leu Val Asp Val Leu Pro Gln His Val Trp Gly Ile Lys Glu 
465                 470                 475                 480 


Met Arg Glu Ala Ala Ile Glu Asn Val Ile Asp Val Met His Ser Tyr 
                485                 490                 495     


Asp Lys Asn Asn Ile Asp Gly Ile Thr Leu Glu Gly Cys Val Lys Thr 
            500                 505                 510         


Phe Leu Lys Glu Arg Tyr Gln Val Ser Asp Asp Asn Leu Lys Lys Leu 
        515                 520                 525             


Tyr His Pro Ser Met Leu Asp Pro Tyr Pro Arg Gln Arg Pro Asn Asp 
    530                 535                 540                 


Glu Gly Val Phe Gln Leu Gly Ser Pro Arg Ile Ser Ser Val Lys Asn 
545                 550                 555                 560 


Pro Met Ala Met His Ser Leu Phe Arg Leu Arg Lys Val Val Asn Leu 
                565                 570                 575     


Met Leu Lys Lys Gly Tyr Ile Thr Pro Asp Thr Lys Val His Ile Glu 
            580                 585                 590         


Phe Ser Arg Asp Leu Asn Asp Ala Asn Lys Arg Trp Ala Ile Gln Thr 
        595                 600                 605             


Trp Gln Arg Glu Asn Glu Lys Glu Arg Glu Arg Cys Arg Lys Glu Ile 
    610                 615                 620                 


Glu Lys Tyr Ile Ala Ser Pro Ser Asp Thr Asp Ile Leu Lys Tyr Gln 
625                 630                 635                 640 


Leu Trp Glu Glu Gln Asn His Lys Cys Leu Tyr Thr Gly Asp Glu Ile 
                645                 650                 655     


Arg Ile Thr Asp Phe Leu Gly Asp Asn Pro Lys Tyr Asp Ile Glu His 
            660                 665                 670         


Thr Ile Pro Arg Ser Ala Gly Gly Asp Ser Thr Lys Met Asn Leu Thr 
        675                 680                 685             


Leu Cys Ser Ser Arg Phe Asn Arg Asp Glu Lys Lys Thr Lys Leu Pro 
    690                 695                 700                 


Ala Glu Leu Val Asn His Asp Glu Ile Leu Glu Arg Ile Ser Asn Trp 
705                 710                 715                 720 


Lys Glu Lys Tyr Glu Asp Ile Asp Lys Gln Ile Arg Lys Ile Ser Thr 
                725                 730                 735     


Lys Gly Ala Thr Ser Lys Glu Asp Lys Asp Ser Lys Ile Arg Arg Arg 
            740                 745                 750         


His Tyr Leu Ile Leu Gln Arg Asp Tyr Trp Arg Gly Lys Tyr Gln Arg 
        755                 760                 765             


Phe Thr Met Thr Glu Val Pro Glu Gly Phe Ser Arg Arg Gln Gly Thr 
    770                 775                 780                 


Asp Ile Ser Val Ile Ser Arg Tyr Ala Arg Met Tyr Leu Lys Ser Val 
785                 790                 795                 800 


Phe Lys Gln Val Tyr Ile Val Lys Gly Ile Ala Thr Ser Asp Phe Arg 
                805                 810                 815     


Lys Met Trp Gly Ile Gln Asp Glu Tyr Ala Lys Lys Glu Arg Val Asn 
            820                 825                 830         


His Val His His Cys Ile Asp Ala Ile Thr Ile Ala Cys Ile Gly Lys 
        835                 840                 845             


Ala Glu Tyr Asp Lys Leu Ala Asp Tyr Arg His Gln Tyr Asp Asp Tyr 
    850                 855                 860                 


Leu Phe Gln Gly Lys Thr Lys Pro Thr Phe Asp Lys Pro Trp Pro Ser 
865                 870                 875                 880 


Phe Val Ile Asp Ile Lys His Ile Gln Asp Glu Leu Leu Ile Ala His 
                885                 890                 895     


Tyr Ala Lys Asp Asn Leu Glu Lys Phe Thr Lys Lys Asn Leu Arg Gly 
            900                 905                 910         


Lys Asp Gly Arg Ile Ile Arg Asp Lys Phe Gly Asn Lys Leu Gln Met 
        915                 920                 925             


Lys Gly Asp Thr Ser Arg Asn Ser Leu His Asn Asp Lys Phe Tyr Gly 
    930                 935                 940                 


Ala Ile Asn His Glu Gly Glu Ile Lys Tyr Val Tyr Arg Thr Asn Ile 
945                 950                 955                 960 


Glu Ala Leu Asp Ala Lys Ser Ile Gly Asn Ile Val Asp Pro Thr Val 
                965                 970                 975     


Arg Ser Ile Ile Glu Ser Ala Ile Ala Ile His Gly Ser Leu Lys Ala 
            980                 985                 990         


Ala Ile Asn Lys Gly Ile Trp Met  Asn Glu Glu Lys His  Ile Pro Ile 
        995                 1000                 1005             


Lys Lys  Val Arg Val Phe Arg  Asn Asp Val Lys Lys  Pro Ile Glu 
    1010                 1015                 1020             


Leu Lys  Asp Gln Arg Asp Leu  Ser Asp Lys Asp Tyr  Lys Gln His 
    1025                 1030                 1035             


Tyr Tyr  Val Thr Asn Asp Gly  Asn Tyr Met Met Leu  Ile Phe Ser 
    1040                 1045                 1050             


Lys Leu  Asn Asn Lys Gly Arg  Glu Ile Arg Gln His  Val Val Ile 
    1055                 1060                 1065             


Asn Ser  Leu Glu Ala Thr Glu  Val Ile Lys Ser His  Lys Arg Ser 
    1070                 1075                 1080             


Gln Val  Gly Lys Val Val Trp  Glu Ser Tyr Tyr Ser  Lys Glu Gly 
    1085                 1090                 1095             


Phe Asp  Leu Ile Tyr Lys Leu  Lys Ser Gly Thr Met  Ile Leu Leu 
    1100                 1105                 1110             


Tyr Glu  Asn Asn Arg Asp Glu  Val Trp Asp Leu Asp  Ile Arg Asn 
    1115                 1120                 1125             


Leu Gln  Lys Arg Leu Tyr Ile  Ile Thr Lys Met Lys  Tyr Asp Gly 
    1130                 1135                 1140             


Arg Ile  Tyr Met Met His His  Gln Glu Ala Arg Glu  Lys Lys Asp 
    1145                 1150                 1155             


Leu Glu  Glu Lys Ser Gly Ser  Phe Lys Ile Asn Glu  Asp Tyr Arg 
    1160                 1165                 1170             


Pro Leu  Ile Val Asn Ser Tyr  Asn Gln Phe Asn Ala  Leu Val Gln 
    1175                 1180                 1185             


Asp Leu  Asp Phe Glu Ile Asn  Asp Leu Gly Glu Ile  Arg Arg Leu 
    1190                 1195                 1200             


Ile 
    


<210> 398
<211> 1424
<212> PRT
<213> Prevotella sp.


<220>
<223> Prevotella sp. C561

<400> 398
Met Thr Gln Lys Val Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly 
1               5                   10                  15      


Ser Ala Val Arg Asn Leu Asp Leu Ser Asp Asp Leu Gln Trp Gln Leu 
            20                  25                  30          


Glu Phe Phe Ser Ser Asp Ile Phe Arg Ser Ser Val Asn Lys Glu Ser 
        35                  40                  45              


Asn Gly Arg Glu Tyr Ser Leu Ala Ala Gln Arg Ser Ala His Arg Arg 
    50                  55                  60                  


Ser Arg Gly Leu Asn Glu Val Arg Arg Arg Arg Leu Trp Ala Thr Leu 
65                  70                  75                  80  


Asn Leu Leu Ile Lys His Gly Phe Cys Pro Met Ser Ser Glu Ser Leu 
                85                  90                  95      


Met Arg Trp Cys Thr Tyr Asp Lys Arg Lys Gly Leu Phe Arg Glu Tyr 
            100                 105                 110         


Pro Ile Asp Asp Lys Asp Phe Asn Ala Trp Ile Leu Leu Asp Phe Asn 
        115                 120                 125             


Gly Asp Gly Arg Pro Asp Tyr Ser Ser Pro Tyr Gln Leu Arg Arg Glu 
    130                 135                 140                 


Leu Val Thr Arg Gln Phe Asp Phe Glu Gln Pro Ile Glu Arg Tyr Lys 
145                 150                 155                 160 


Leu Gly Arg Ala Leu Tyr His Ile Ala Gln His Arg Gly Phe Lys Ser 
                165                 170                 175     


Ser Lys Gly Glu Thr Leu Ser Gln Gln Glu Thr Asn Ser Lys Pro Ser 
            180                 185                 190         


Ser Thr Asp Glu Ile Pro Asp Val Ala Gly Ala Met Lys Ala Ser Glu 
        195                 200                 205             


Glu Lys Leu Ser Lys Gly Leu Ser Thr Tyr Met Lys Glu His Asn Leu 
    210                 215                 220                 


Leu Thr Val Gly Ala Ala Phe Ala Gln Leu Glu Asp Glu Gly Val Arg 
225                 230                 235                 240 


Val Arg Asn Asn Asn Asp Tyr Arg Ala Ile Arg Ser Gln Phe Gln His 
                245                 250                 255     


Glu Ile Glu Thr Ile Phe Lys Phe Gln Gln Gly Leu Ser Val Glu Ser 
            260                 265                 270         


Glu Leu Tyr Glu Arg Leu Ile Ser Glu Lys Lys Asn Val Gly Thr Ile 
        275                 280                 285             


Phe Tyr Lys Arg Pro Leu Arg Ser Gln Arg Gly Asn Val Gly Lys Cys 
    290                 295                 300                 


Thr Leu Glu Arg Ser Lys Pro Arg Cys Ala Ile Gly His Pro Leu Phe 
305                 310                 315                 320 


Glu Lys Phe Arg Ala Trp Thr Leu Ile Asn Asn Ile Lys Val Arg Met 
                325                 330                 335     


Ser Val Asp Thr Leu Asp Glu Gln Leu Pro Met Lys Leu Arg Leu Asp 
            340                 345                 350         


Leu Tyr Asn Glu Cys Phe Leu Ala Phe Val Arg Thr Glu Phe Lys Phe 
        355                 360                 365             


Glu Asp Ile Arg Lys Tyr Leu Glu Lys Arg Leu Gly Ile His Phe Ser 
    370                 375                 380                 


Tyr Asn Asp Lys Thr Ile Asn Tyr Lys Asp Ser Thr Ser Val Ala Gly 
385                 390                 395                 400 


Cys Pro Ile Thr Ala Arg Phe Arg Lys Met Leu Gly Glu Glu Trp Glu 
                405                 410                 415     


Ser Phe Arg Val Glu Gly Gln Lys Glu Arg Gln Ala His Ser Lys Asn 
            420                 425                 430         


Asn Ile Ser Phe His Arg Val Ser Tyr Ser Ile Glu Asp Ile Trp His 
        435                 440                 445             


Phe Cys Tyr Asp Ala Glu Glu Pro Glu Ala Val Leu Ala Phe Ala Gln 
    450                 455                 460                 


Glu Thr Leu Arg Leu Glu Arg Lys Lys Ala Glu Glu Leu Val Arg Ile 
465                 470                 475                 480 


Trp Ser Ala Met Pro Gln Gly Tyr Ala Met Leu Ser Gln Lys Ala Ile 
                485                 490                 495     


Arg Asn Ile Asn Lys Ile Leu Met Leu Gly Leu Lys Tyr Ser Asp Ala 
            500                 505                 510         


Val Ile Leu Ala Lys Val Pro Glu Leu Val Asp Val Ser Asp Glu Glu 
        515                 520                 525             


Leu Leu Ser Ile Ala Lys Asp Tyr Tyr Leu Val Glu Ala Gln Val Asn 
    530                 535                 540                 


Tyr Asp Lys Arg Ile Asn Ser Ile Val Asn Gly Leu Ile Ala Lys Tyr 
545                 550                 555                 560 


Lys Ser Val Ser Glu Glu Tyr Arg Phe Ala Asp His Asn Tyr Glu Tyr 
                565                 570                 575     


Leu Leu Asp Glu Ser Asp Glu Lys Asp Ile Ile Arg Gln Ile Glu Asn 
            580                 585                 590         


Ser Leu Gly Ala Arg Arg Trp Ser Leu Met Asp Ala Asn Glu Gln Thr 
        595                 600                 605             


Asp Ile Leu Gln Lys Val Arg Asp Arg Tyr Gln Asp Phe Phe Arg Ser 
    610                 615                 620                 


His Glu Arg Lys Phe Val Glu Ser Pro Lys Leu Gly Glu Ser Phe Glu 
625                 630                 635                 640 


Asn Tyr Leu Thr Lys Lys Phe Pro Met Val Glu Arg Glu Gln Trp Lys 
                645                 650                 655     


Lys Leu Tyr His Pro Ser Gln Ile Thr Ile Tyr Arg Pro Val Ser Val 
            660                 665                 670         


Gly Lys Asp Arg Ser Val Leu Arg Leu Gly Asn Pro Asp Ile Gly Ala 
        675                 680                 685             


Ile Lys Asn Pro Thr Val Leu Arg Val Leu Asn Thr Leu Arg Arg Arg 
    690                 695                 700                 


Val Asn Gln Leu Leu Asp Asp Gly Val Ile Ser Pro Asp Glu Thr Arg 
705                 710                 715                 720 


Val Val Val Glu Thr Ala Arg Glu Leu Asn Asp Ala Asn Arg Lys Trp 
                725                 730                 735     


Ala Leu Asp Thr Tyr Asn Arg Ile Arg His Asp Glu Asn Glu Lys Ile 
            740                 745                 750         


Lys Lys Ile Leu Glu Glu Phe Tyr Pro Lys Arg Asp Gly Ile Ser Thr 
        755                 760                 765             


Asp Asp Ile Asp Lys Ala Arg Tyr Val Ile Asp Gln Arg Glu Val Asp 
    770                 775                 780                 


Tyr Phe Thr Gly Ser Lys Thr Tyr Asn Lys Asp Ile Lys Lys Tyr Lys 
785                 790                 795                 800 


Phe Trp Leu Glu Gln Gly Gly Gln Cys Met Tyr Thr Gly Arg Thr Ile 
                805                 810                 815     


Asn Leu Ser Asn Leu Phe Asp Pro Asn Ala Phe Asp Ile Glu His Thr 
            820                 825                 830         


Ile Pro Glu Ser Leu Ser Phe Asp Ser Ser Asp Met Asn Leu Thr Leu 
        835                 840                 845             


Cys Asp Ala His Tyr Asn Arg Phe Ile Lys Lys Asn His Ile Pro Thr 
    850                 855                 860                 


Asp Met Pro Asn Tyr Asp Lys Ala Ile Thr Ile Asp Gly Lys Glu Tyr 
865                 870                 875                 880 


Pro Ala Ile Thr Ser Gln Leu Gln Arg Trp Val Glu Arg Val Glu Arg 
                885                 890                 895     


Leu Asn Arg Asn Val Glu Tyr Trp Lys Gly Gln Ala Arg Arg Ala Gln 
            900                 905                 910         


Asn Lys Asp Arg Lys Asp Gln Cys Met Arg Glu Met His Leu Trp Lys 
        915                 920                 925             


Met Glu Leu Glu Tyr Trp Lys Lys Lys Leu Glu Arg Phe Thr Val Thr 
    930                 935                 940                 


Glu Val Thr Asp Gly Phe Lys Asn Ser Gln Leu Val Asp Thr Arg Val 
945                 950                 955                 960 


Ile Thr Arg His Ala Val Leu Tyr Leu Lys Ser Ile Phe Pro His Val 
                965                 970                 975     


Asp Val Gln Arg Gly Asp Val Thr Ala Lys Phe Arg Lys Ile Leu Gly 
            980                 985                 990         


Ile Gln Ser Val Asp Glu Lys Lys  Asp Arg Ser Leu His  Ser His His 
        995                 1000                 1005             


Ala Ile  Asp Ala Thr Thr Leu  Thr Ile Ile Pro Val  Ser Ala Lys 
    1010                 1015                 1020             


Arg Asp  Arg Met Leu Glu Leu  Phe Ala Lys Ile Glu  Glu Ile Asn 
    1025                 1030                 1035             


Lys Met  Leu Ser Phe Ser Gly  Ser Glu Asp Arg Thr  Gly Leu Ile 
    1040                 1045                 1050             


Gln Glu  Leu Glu Gly Leu Lys  Asn Lys Leu Gln Met  Glu Val Lys 
    1055                 1060                 1065             


Val Cys  Arg Ile Gly His Asn  Val Ser Glu Ile Gly  Thr Phe Ile 
    1070                 1075                 1080             


Asn Asp  Asn Ile Ile Val Asn  His His Ile Lys Asn  Gln Ala Leu 
    1085                 1090                 1095             


Thr Pro  Val Arg Arg Arg Leu  Arg Lys Lys Gly Tyr  Ile Val Gly 
    1100                 1105                 1110             


Gly Val  Asp Asn Pro Arg Trp  Gln Thr Gly Asp Ala  Leu Arg Gly 
    1115                 1120                 1125             


Glu Ile  His Lys Ala Ser Tyr  Tyr Gly Ala Ile Thr  Gln Phe Ala 
    1130                 1135                 1140             


Lys Asp  Asp Glu Gly Lys Val  Leu Met Lys Glu Gly  Arg Pro Gln 
    1145                 1150                 1155             


Val Asn  Pro Thr Ile Lys Phe  Val Ile Arg Arg Glu  Leu Lys Tyr 
    1160                 1165                 1170             


Lys Lys  Ser Ala Ala Asp Ser  Gly Phe Ala Ser Trp  Asp Asp Leu 
    1175                 1180                 1185             


Gly Lys  Ala Ile Val Asp Lys  Glu Leu Phe Ala Leu  Met Lys Gly 
    1190                 1195                 1200             


Gln Phe  Pro Ala Glu Thr Ser  Phe Lys Asp Ala Cys  Glu Gln Gly 
    1205                 1210                 1215             


Ile Tyr  Met Ile Lys Lys Gly  Lys Asn Gly Met Pro  Asp Ile Lys 
    1220                 1225                 1230             


Leu His  His Ile Arg His Val  Arg Cys Glu Ala Pro  Gln Ser Gly 
    1235                 1240                 1245             


Leu Lys  Ile Lys Glu Gln Thr  Tyr Lys Ser Glu Lys  Glu Tyr Lys 
    1250                 1255                 1260             


Arg Tyr  Phe Tyr Ala Ala Val  Gly Asp Leu Tyr Ala  Met Cys Cys 
    1265                 1270                 1275             


Tyr Thr  Asn Gly Lys Ile Arg  Glu Phe Arg Ile Tyr  Ser Leu Tyr 
    1280                 1285                 1290             


Asp Val  Ser Cys His Arg Lys  Ser Asp Ile Glu Asp  Ile Pro Glu 
    1295                 1300                 1305             


Phe Ile  Thr Asp Lys Lys Gly  Asn Arg Leu Met Leu  Asp Tyr Lys 
    1310                 1315                 1320             


Leu Arg  Thr Gly Asp Met Ile  Leu Leu Tyr Lys Asp  Asn Pro Ala 
    1325                 1330                 1335             


Glu Leu  Tyr Asp Leu Asp Asn  Val Asn Leu Ser Arg  Arg Leu Tyr 
    1340                 1345                 1350             


Lys Ile  Asn Arg Phe Glu Ser  Gln Ser Asn Leu Val  Leu Met Thr 
    1355                 1360                 1365             


His His  Leu Ser Thr Ser Lys  Glu Arg Gly Arg Ser  Leu Gly Lys 
    1370                 1375                 1380             


Thr Val  Asp Tyr Gln Asn Leu  Pro Glu Ser Ile Arg  Ser Ser Val 
    1385                 1390                 1395             


Lys Ser  Leu Asn Phe Leu Ile  Met Gly Glu Asn Arg  Asp Phe Val 
    1400                 1405                 1410             


Ile Lys  Asn Gly Lys Ile Ile  Phe Asn His Arg 
    1415                 1420                 


<210> 399
<211> 1483
<212> PRT
<213> Prevotella sp.


<220>
<223> Prevotella sp. MSX73

<400> 399
Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Lys Val Ser Val Asp Asp Tyr Gly Asn Tyr Leu His Asp Ile Lys 
            20                  25                  30          


Leu Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Val Leu Gly Asn Phe 
        35                  40                  45              


Asp Ser Gly Val Thr Val Ser Gln Thr Ala Gln Arg Thr Glu Phe Arg 
    50                  55                  60                  


Ser Lys Arg Arg Leu Val Gln Arg Asn Leu Gln Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu His Val Leu Asp Phe Leu Pro Ala His Tyr Asp Ala 
                85                  90                  95      


Ala Ile Gly Trp Asp Arg Thr Glu Ala Val Thr Tyr Gly Lys Phe Leu 
            100                 105                 110         


Asn His Ala Glu Pro Lys Leu Ala Trp Glu Glu Leu Gly Asn Gly Lys 
        115                 120                 125             


Arg Arg Phe Leu Phe Met Asp Ser Phe His Glu Met Val Ala Asp Phe 
    130                 135                 140                 


Ala Arg Cys Gln Pro Ala Leu Val Ala Asp Gly Lys Lys Ile Pro Leu 
145                 150                 155                 160 


Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Gln Ala Ile 
                165                 170                 175     


Thr Lys Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg 
            180                 185                 190         


Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Glu Glu Glu Asn Pro Thr Lys 
        195                 200                 205             


Gln Glu Glu Tyr Tyr Glu Leu Lys Val Val Ser Val Glu Ala Thr Asp 
    210                 215                 220                 


Ser Arg Lys Gly Asn Asp Thr Trp Tyr Asn Val His Leu Glu Asn Gly 
225                 230                 235                 240 


Trp Ile Tyr Arg Arg Ser Ser Lys Ile Ser Leu Asp Asp Trp Val Gly 
                245                 250                 255     


Lys Val Lys Gln Phe Ile Val Thr Thr Glu Tyr Glu Lys Asp Gly Thr 
            260                 265                 270         


Thr Leu Lys Thr Asp Lys Glu Gly Asn Val Lys Arg Ser Phe Arg Ala 
        275                 280                 285             


Pro Asn Glu Asn Asp Trp Gly Leu Arg Lys Lys Arg Thr Glu Thr Leu 
    290                 295                 300                 


Leu Glu Met Ser Gly Lys Thr Val Gly Ala Phe Ile Tyr Asp His Leu 
305                 310                 315                 320 


Leu Gln Glu Pro Ala Asp Lys Ile Arg Gly Asn Phe Ile Arg Thr Ile 
                325                 330                 335     


Glu Arg His Tyr Tyr Lys Ala Glu Leu Glu Ala Ile Leu Ala Glu Gln 
            340                 345                 350         


Cys Lys Tyr His Ile Glu Leu Arg Asp Lys Glu Met Leu Glu Ala Cys 
        355                 360                 365             


Ala Arg Glu Leu Tyr Leu Asn Asn Leu Pro His Gln Arg Ser Leu Met 
    370                 375                 380                 


Lys Lys Asp Met Thr Tyr Leu Leu Leu Tyr Asp Leu Ile Phe Tyr Gln 
385                 390                 395                 400 


Arg Pro Leu Lys Ser Lys Lys Ala Leu Ile Ala Asn Cys Pro Tyr Glu 
                405                 410                 415     


Tyr Tyr Glu Tyr Val Asp Lys Glu Thr Gly Glu Ile Lys Arg Gln Asn 
            420                 425                 430         


Ile Lys Cys Ile Ala Lys Ser Asn Pro Tyr Phe Gln Glu Phe Arg Leu 
        435                 440                 445             


Trp Gln Phe Val Leu Asn Leu Arg Leu Phe Asp Arg Val Glu Asp Lys 
    450                 455                 460                 


Glu Val Thr Ala Asn Tyr Leu Pro Thr Ala Asp Asp His Ala Arg Leu 
465                 470                 475                 480 


Phe Thr Tyr Leu Asn Asp Arg Lys Glu Ile Asn Gln Glu Thr Leu Leu 
                485                 490                 495     


Lys Asp Tyr Phe Lys Leu Lys Lys Val Lys Ile Gly Asn Glu Lys Glu 
            500                 505                 510         


Tyr Pro Ile Arg Trp Asn Tyr Ile Glu Asp Lys Glu Lys Lys Tyr Pro 
        515                 520                 525             


Cys Asn Glu Thr Arg Tyr Glu Leu Leu Met Ala Leu Asp Arg Ala Gly 
    530                 535                 540                 


Ile Glu His Lys Trp Leu Asp Asp Asn Asn Leu Glu Tyr Arg Leu Trp 
545                 550                 555                 560 


His Leu Leu Tyr Ser Val Glu Val Lys Ser Glu Ser Glu Thr Ala Leu 
                565                 570                 575     


Arg Lys Leu Lys Asn Asp Asp Ala Phe Val Asn Ser Phe Leu Lys Val 
            580                 585                 590         


Lys Pro Phe Lys Lys Glu Tyr Gly Ala Tyr Ser Glu Lys Ala Ile Lys 
        595                 600                 605             


Arg Leu Leu Ala Val Met Arg Lys Gly Phe Leu Trp Asn Glu Gln Asp 
    610                 615                 620                 


Ile Cys Asp Glu Thr Arg Lys Arg Ile Glu Ile Ile Ile Lys Gly Asp 
625                 630                 635                 640 


Val Asp Glu Lys Val Lys Glu Arg Met Gly His Ala Ala Tyr Ser Phe 
                645                 650                 655     


Asp Arg Val Ser Asp Phe Gln Gly Leu Pro Glu Trp Leu Ala Cys Tyr 
            660                 665                 670         


Val Val Tyr Gly Arg His Ser Glu Ala Met Asp Ile Gln Arg Trp Asp 
        675                 680                 685             


Ser Pro Glu Arg Leu Met Ala Tyr Ile Asn Asn Phe Lys Gln Tyr Ser 
    690                 695                 700                 


Leu Arg Asn Pro Ile Val Glu Gln Cys Ile Leu Glu Thr Leu Arg Thr 
705                 710                 715                 720 


Val His Asp Ile Trp Lys Glu Thr Gly Gln Ile Asp Glu Ile His Val 
                725                 730                 735     


Glu Leu Gly Arg Glu Met Lys Ser Thr Ser Glu Glu Arg Ala Arg Arg 
            740                 745                 750         


Thr Gln Asn Val Leu Arg Asn Glu Asn Thr Asn Leu Arg Ile Lys Ser 
        755                 760                 765             


Leu Leu Ile Glu Leu Lys Asn Asp Thr Asp Ile Cys Asn Val His Pro 
    770                 775                 780                 


Tyr Ser Pro Met Gln Gln Glu Ile Leu Arg Ile Tyr Glu Glu Gly Ala 
785                 790                 795                 800 


Leu Gln Glu Leu Asn Arg Glu Asp Glu Asp Phe Glu Glu Ile Ser Lys 
                805                 810                 815     


Ile Ser Gln Met Ser Gln Pro Ser Gly Lys Glu Leu Asn Arg Tyr Lys 
            820                 825                 830         


Leu Trp Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Lys Ala Ile 
        835                 840                 845             


Ser Leu Ala Lys Leu Phe Thr Pro Ala Tyr Gln Ile Glu His Val Ile 
    850                 855                 860                 


Pro Gln Ser Arg Tyr Phe Asp Asp Ser Phe Thr Asn Lys Val Ile Cys 
865                 870                 875                 880 


Glu Ala Glu Val Asn Thr Leu Lys Ser Asn Leu Leu Gly Tyr Glu Phe 
                885                 890                 895     


Ile Lys Lys His Gly Gly Glu Ile Ile His Cys Thr Thr Leu Gly Asp 
            900                 905                 910         


Val Arg Ile Phe Ser Glu Ser Glu Tyr Lys Ala Phe Val Met Asp His 
        915                 920                 925             


Tyr Ala Asn Asn Lys Ser Lys Lys Asp Lys Leu Leu Met Glu Asp Ile 
    930                 935                 940                 


Pro Gln Glu Phe Leu Ser Arg Gln Met Asn Asp Ser Arg Tyr Ile Ser 
945                 950                 955                 960 


Lys Val Val Lys Thr Leu Leu Ser Asn Ile Val Arg Met Ala Asp Glu 
                965                 970                 975     


Ser Glu Ala Thr Ser Lys Ser Val Ile Val Cys Thr Gly Gly Val Thr 
            980                 985                 990         


Asp Arg Leu Lys Lys Asp Trp Gly  Leu Asn Asp Val Trp  Asn Ser Ile 
        995                 1000                 1005             


Val Tyr  Ser Arg Phe Glu Arg  Leu Asn Arg Leu Thr  Gly Thr Glu 
    1010                 1015                 1020             


Ala Phe  Gly His Trp Glu Asn  Lys Asp Gly Lys Arg  Val Phe Gln 
    1025                 1030                 1035             


Thr Ser  Met Pro Leu Glu Leu  Gln Arg Gly Phe Arg  Lys Lys Arg 
    1040                 1045                 1050             


Ile Asp  His Arg His His Ala  Met Asp Ala Leu Val  Ile Ala Cys 
    1055                 1060                 1065             


Ala Ser  Arg Asn Ile Val Asn  Tyr Leu Asn Asn Glu  Ser Ala Asn 
    1070                 1075                 1080             


Asn Pro  Lys Lys Arg Glu Asp  Leu Arg Arg Gln Leu  Cys Asp Lys 
    1085                 1090                 1095             


Asn Arg  Val Ile Arg Lys Pro  Trp Glu Thr Phe Thr  Gln Asp Ala 
    1100                 1105                 1110             


Tyr Asn  Ala Leu Glu Asn Val  Val Val Ser Phe Lys  Asn Tyr Val 
    1115                 1120                 1125             


Arg Val  Ile Asn Lys Ala Thr  Asn Arg Tyr Glu His  Tyr Asp Glu 
    1130                 1135                 1140             


Asn Gly  Lys Lys Arg Phe Val  Gln Gln Lys Gly Ser  Glu Leu Trp 
    1145                 1150                 1155             


Ala Ile  Arg Lys Pro Met His  Lys Glu Thr Tyr Tyr  Gly His Val 
    1160                 1165                 1170             


Asn Leu  Arg Arg Lys Glu Leu  Val Thr Leu Gln Lys  Ala Leu Asp 
    1175                 1180                 1185             


Asp Ile  Pro Ser Ile Cys Asp  Lys Lys Leu Arg Asp  Tyr Ile Ser 
    1190                 1195                 1200             


Ala Leu  Val Glu Lys His Phe  Asn Lys Arg Gln Leu  Leu Ala His 
    1205                 1210                 1215             


Phe Lys  Ser Thr Asp Tyr Tyr  Trp Gln Lys Gln Tyr  Val Asn Lys 
    1220                 1225                 1230             


Val Tyr  Val Trp Thr Phe Ser  Asp Asp Ile Lys Pro  Leu Val Ala 
    1235                 1240                 1245             


Thr Arg  Lys Leu Leu Asp Thr  Ser Phe Asp Ala Lys  Arg Ile Gly 
    1250                 1255                 1260             


Thr Ile  Thr Asp Thr Gly Ile  Gln Lys Ile Leu Arg  Asn Tyr Leu 
    1265                 1270                 1275             


Glu Ala  Lys Gly Gly Asn Ala  Thr Leu Ala Phe Thr  Pro Glu Gly 
    1280                 1285                 1290             


Ile Val  Glu Met Asn Gln Asn  Ile Ser Lys Tyr Asn  Asp Gly Lys 
    1295                 1300                 1305             


Pro His  Gln Pro Ile Leu Lys  Val Arg Ile Thr Glu  Pro Met Gly 
    1310                 1315                 1320             


Ala Lys  Tyr Arg Val Gly Gln  Thr Glu Asn Lys Met  Ala Lys Tyr 
    1325                 1330                 1335             


Val Glu  Ala Gln Ser Gly Thr  Asn Leu Tyr Phe Ala  Ile Tyr Glu 
    1340                 1345                 1350             


Asp Ser  Glu Gly Lys Arg Ser  Tyr Thr Thr Val Pro  Leu Asp Glu 
    1355                 1360                 1365             


Val Ala  Glu Arg Leu Lys Gln  Arg Leu Ser Pro Val  Pro Glu Lys 
    1370                 1375                 1380             


Asp Glu  Asn Asp Val Pro Leu  Lys Phe Tyr Leu Ser  Pro Asn Asp 
    1385                 1390                 1395             


Leu Val  Tyr Val Pro Thr Glu  Glu Glu Leu Gln Leu  Arg Glu Cys 
    1400                 1405                 1410             


Lys Leu  Asn Lys Asp Arg Ile  Tyr Lys Met Val Ser  Ser Thr Gly 
    1415                 1420                 1425             


Ser Glu  Cys His Phe Ile Pro  Tyr Tyr Val Ala Asn  Val Ile Tyr 
    1430                 1435                 1440             


Asn Lys  Val Glu Phe Glu Ala  Lys Asn Lys Ile Gly  Arg Ala Leu 
    1445                 1450                 1455             


Thr Gly  Glu Met Ile Lys Ala  Val Cys Trp Lys Leu  Glu Ile Asp 
    1460                 1465                 1470             


Arg Leu  Gly Asn Ile Leu Lys  Val Ile Lys 
    1475                 1480             


<210> 400
<211> 1375
<212> PRT
<213> Prevotella sp.


<220>
<223> Prevotella sp. oral taxon 306 str. F0472

<400> 400
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ser Glu Asn Lys Asp Glu Gln Ser Ser Ile Val 
            20                  25                  30          


Arg Leu Gly Val Arg Val Ile Pro Leu Thr Val Asp Glu Lys Gly Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ala Ile Thr Thr Asn Ala Asp Arg Gln Gln Val 
    50                  55                  60                  


His Ala Ala Arg Ile Asn Leu Gln Arg Tyr Lys Leu Arg Arg Glu Asn 
65                  70                  75                  80  


Leu Arg Asp Cys Leu Gln Lys Gln Gly Trp Ile Gly Ser Glu Pro Met 
                85                  90                  95      


Cys Glu Asp Gly Lys Ser Ser Thr Phe Glu Thr Tyr Lys Leu Arg Ala 
            100                 105                 110         


Lys Ala Ala Val Glu Glu Val Ser Leu His Glu Phe Ala Arg Val Leu 
        115                 120                 125             


Phe Met Leu Asn Lys Lys Arg Gly Tyr Lys Ser Asn Arg Lys Ala Asn 
    130                 135                 140                 


Asp Lys Glu Glu Gly Lys Leu Phe Asp Gly Met Thr Ile Ala Lys Lys 
145                 150                 155                 160 


Leu Tyr Glu Glu His Leu Thr Pro Ala Glu Tyr Ser Leu Gln Leu Leu 
                165                 170                 175     


Asn Thr Gly Arg Lys Phe Thr Pro Glu Tyr Tyr Arg Ser Asp Leu Ile 
            180                 185                 190         


Glu Glu Phe Glu Lys Ile Trp Asn Glu Gln Gln Lys Tyr Tyr Pro Glu 
        195                 200                 205             


Ile Leu Thr Asp Glu Phe Lys Gln Gln Leu Glu Gly Lys Ala Lys Ser 
    210                 215                 220                 


Asn Thr Ser Lys Leu Phe Leu Gly Lys Tyr Gly Ile Tyr Ser Ala Asp 
225                 230                 235                 240 


Thr Lys Gly Leu Asp Arg Arg Leu Gln Pro Leu Lys Trp Arg Val Glu 
                245                 250                 255     


Ala Met Lys Gln Gln Val Asp Lys Asp Val Leu Ala Phe Val Ile Ser 
            260                 265                 270         


Asp Leu Lys Gly Gln Ile Ala Asn Thr Ser Gly Leu Leu Gly Ala Ile 
        275                 280                 285             


Ser Asp Arg Ser Lys Glu Leu Tyr Phe Ser Lys Gln Thr Ile Gly Gln 
    290                 295                 300                 


Tyr Leu Trp Ala Ser Leu Gln Glu Asn Pro His Ile Ser Ile Lys Asn 
305                 310                 315                 320 


Gln Pro Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu Lys Ile Trp 
                325                 330                 335     


Glu Thr Gln Ala Thr Tyr His Lys Glu Leu Thr Ser Glu Leu Lys Gln 
            340                 345                 350         


Glu Ile Arg Asp Ile Ile Ile Phe Tyr Gln Arg Pro Leu Lys Ser Lys 
        355                 360                 365             


Lys Asn Leu Ile Ala Val Cys Glu Leu Glu Gln Arg Lys Val Lys Val 
    370                 375                 380                 


Thr Val Asp Gly Lys Glu Lys Glu Ile Thr Ile Gly Pro Lys Ile Ala 
385                 390                 395                 400 


Pro Lys Ser Ser Pro Met Phe Gln Glu Phe Arg Ile Trp Gln Asn Leu 
                405                 410                 415     


Asn Asn Ile Leu Leu Leu Asp His Glu Thr Asn Ser Lys Arg Pro Leu 
            420                 425                 430         


Tyr Glu Glu Glu Arg Asn Leu Leu Tyr Glu Glu Leu Ser Val Lys Glu 
        435                 440                 445             


Lys Leu Ser Lys Thr Glu Ala Leu Lys Val Leu Gly Lys Lys Ser Lys 
    450                 455                 460                 


Gln Trp Asp Leu Asn Tyr Lys Glu Leu Glu Gly Asn Arg Thr Gln Ala 
465                 470                 475                 480 


Val Leu Tyr Asp Cys Tyr Asn Arg Ile Ile Val Met Ser Gly His Glu 
                485                 490                 495     


Glu Cys Asn Phe Lys Lys Leu Lys Ala Ser Asp Ile Arg His Tyr Val 
            500                 505                 510         


Lys Met Ile Phe Lys Asn Leu Ala Phe Asn Thr Asp Ile Leu Cys Phe 
        515                 520                 525             


Asp Ser Ser Leu Lys Gly His Glu Leu Glu Arg Gln Pro Met Cys Gln 
    530                 535                 540                 


Leu Trp His Leu Leu Tyr Ser Tyr Glu Gly Asp Asn Ser Arg Thr Gly 
545                 550                 555                 560 


Asn Asp Ala Leu Leu Arg Lys Leu Glu Thr Ser Phe Gly Phe Pro Lys 
                565                 570                 575     


Glu Tyr Ala Ala Val Leu Ala Asp Val Ile Phe Glu Asp Ser Tyr Gly 
            580                 585                 590         


Asn Leu Ser Val Lys Ala Met Arg Asn Ile Leu Pro His Leu Gln Ala 
        595                 600                 605             


Gly Lys Asp Tyr Ser Gln Ala Cys Glu Glu Ala Gly Tyr Lys His Ser 
    610                 615                 620                 


Arg Arg Ser Leu Thr Lys Glu Glu Leu Asn Gln Lys Val Tyr Lys Glu 
625                 630                 635                 640 


Lys Leu Glu Leu Leu Pro Lys Asn Ser Leu His Asn Pro Val Val Glu 
                645                 650                 655     


Lys Ile Leu Asn Gln Met Val Asn Val Ile Asn Ala Val Ile Glu Glu 
            660                 665                 670         


Tyr Gly Lys Pro Asp Glu Ile Arg Ile Glu Leu Ala Arg Asp Leu Lys 
        675                 680                 685             


Ile Gly Ala Ala Glu Arg Glu Asn Met Thr Arg Ser Ile Asn Gln Gly 
    690                 695                 700                 


Asn Ala Glu Asn Lys Arg Ile Arg Glu Ile Leu Glu Lys Glu Phe Ala 
705                 710                 715                 720 


Leu Ser Tyr Leu Ser Arg Asn Asp Ile Ile Lys Tyr Lys Leu Tyr Glu 
                725                 730                 735     


Glu Leu Lys Ser Asn Gly Phe Lys Thr Leu Tyr Ser Asp Thr Tyr Ile 
            740                 745                 750         


Ser Lys Asp Lys Leu Phe Ser Lys Asp Phe Asp Ile Glu His Ile Ile 
        755                 760                 765             


Pro Lys Ala Arg Leu Phe Asp Asp Ser Leu Ser Asn Lys Thr Ile Glu 
    770                 775                 780                 


Ala Arg Asp Val Asn Ile Ala Lys Ser Asn Lys Thr Ala Phe Asp Phe 
785                 790                 795                 800 


Ile Leu Glu Arg Tyr Gly Glu Gln Gly Val Lys Thr Tyr Lys Thr Lys 
                805                 810                 815     


Leu Leu Arg Leu Leu Glu Asp Gly Ala Ile Ser Asn Lys Lys Tyr Asn 
            820                 825                 830         


Asn Leu Leu Lys Thr Glu Ala Asp Ile Pro Ser Gly Phe Ile Asp Arg 
        835                 840                 845             


Asp Leu Arg Asn Thr Gln Tyr Ile Ala Lys Lys Ala Tyr Glu Ile Leu 
    850                 855                 860                 


Ser Glu Leu Val Lys Ile Val Thr Pro Thr Thr Gly Ser Val Thr Asn 
865                 870                 875                 880 


Arg Leu Arg Glu Asp Trp Gln Leu Val Asp Val Met Lys Glu Leu Asn 
                885                 890                 895     


Phe Glu Lys Tyr Gln Lys Leu Gly Leu Ala Asp Val Ile Glu Asp Arg 
            900                 905                 910         


Asp Gly Arg Lys Val Lys Arg Ile Lys Asp Trp Thr Lys Arg Asn Asp 
        915                 920                 925             


His Arg His His Ala Met Asp Ala Leu Thr Ile Ala Phe Thr Lys Pro 
    930                 935                 940                 


Ser Tyr Ile Gln Tyr Leu Asn Asn Leu Asn Ala Arg Ser Asp Lys Ser 
945                 950                 955                 960 


Ser Ser Ile Tyr Gly Ile Glu Val Lys Glu Leu His Arg Glu Glu Gly 
                965                 970                 975     


Lys Phe Arg Phe Asn Ala Pro Leu Pro Ile Asn Glu Phe Arg Ala Glu 
            980                 985                 990         


Ala Lys Arg His Leu Lys Ser Val  Leu Val Ser Ile Lys  Ala Lys Lys 
        995                 1000                 1005             


Lys Val  Met Thr Gln Asn Val  Asn Lys Ile Lys Thr  Lys His Gly 
    1010                 1015                 1020             


Ile Ile  Lys Lys Val Gln Leu  Thr Pro Arg Gly Glu  Leu His Asn 
    1025                 1030                 1035             


Ala Thr  Tyr Tyr Gly Thr Lys  Lys Arg Pro Leu Val  Arg Met Val 
    1040                 1045                 1050             


Lys Val  Gly Ala Ala Leu Asp  Glu Ala Thr Ile Lys  Arg Val Cys 
    1055                 1060                 1065             


Ser Pro  Ala Ile Arg Ala Ala  Leu Leu Lys Arg Leu  Asn Ala Tyr 
    1070                 1075                 1080             


Asn Gly  Asp Ala Lys Glu Ala  Phe Thr Gly Arg Asn  Ser Ile Asp 
    1085                 1090                 1095             


Lys Asn  Pro Ile Tyr Leu Asp  Ile Glu Gln Thr Lys  Leu Val Pro 
    1100                 1105                 1110             


Val Leu  Val Lys Thr Ile Glu  Trp Gly Met Tyr His  Pro Ile Arg 
    1115                 1120                 1125             


Lys Arg  Ile Thr Pro Asp Leu  Lys Ile Asp Lys Val  Ile Asp Lys 
    1130                 1135                 1140             


Gly Ile  Arg Glu Lys Leu Lys  Ala Arg Leu Ala Glu  Phe Asn Gly 
    1145                 1150                 1155             


Asp Ala  Gln Lys Ala Phe Ser  Asn Leu Asp Glu Asn  Pro Ile Tyr 
    1160                 1165                 1170             


Met Asp  Glu Ala Lys Arg Ile  Thr Leu Lys Arg Val  Ser Ile Glu 
    1175                 1180                 1185             


Gly Val  Leu Ser Ala Ile Pro  Leu His Thr Leu Lys  Asp Lys Ala 
    1190                 1195                 1200             


Gly Lys  Pro Val Ile Gly Ser  Asp Gly Lys Pro Val  Phe Gly Asp 
    1205                 1210                 1215             


Tyr Val  Gln Thr Ser Asn Asn  His His Ile Ala Phe  Tyr Ile Asp 
    1220                 1225                 1230             


Asp Lys  Gly Asn Leu Gln Asp  Asn Pro Val Ser Phe  Phe Glu Ala 
    1235                 1240                 1245             


Ala Glu  Arg Lys Ser Gln Gly  Val Pro Val Ile Asp  Arg Arg Tyr 
    1250                 1255                 1260             


Asn Cys  Asp Lys Gly Trp His  Phe Val Phe Thr Met  Lys Gln Asn 
    1265                 1270                 1275             


Glu Tyr  Phe Val Phe Pro Asn  Glu Ala Thr Gly Phe  Ile Pro Ser 
    1280                 1285                 1290             


Glu Val  Asp Leu Leu Asp Glu  Ala Asn Tyr Cys Ile  Ile Ser Pro 
    1295                 1300                 1305             


Asn Leu  Tyr Arg Val Gln Lys  Leu Ser Lys Ala Ser  Gly Arg Asp 
    1310                 1315                 1320             


Tyr Trp  Phe Arg His His Leu  Glu Thr Met Leu Asn  Asp Asp Leu 
    1325                 1330                 1335             


Arg Leu  Lys Asn Ser Thr Phe  Lys Arg Ile Gln Ser  Leu Lys Gly 
    1340                 1345                 1350             


Leu Glu  Asp Ile Val Lys Val  Arg Ile Asn Ser Ile  Gly Lys Ile 
    1355                 1360                 1365             


Val Ala  Val Gly Lys Tyr Asp  
    1370                 1375 


<210> 401
<211> 1216
<212> PRT
<213> Prevotella stercorea


<220>
<223> Prevotella stercorea DSM 18206

<400> 401
Met Thr Lys Ile Leu Gly Ile Asp Thr Gly Thr Asn Ser Leu Gly Trp 
1               5                   10                  15      


Ala Ile Val Asp Lys Thr Ala Asp Asn Tyr Asn Leu Leu Asp Lys Gly 
            20                  25                  30          


Val Asn Ile Phe Gln Glu Gly Val Lys Ile Glu Lys Gly Ile Glu Ser 
        35                  40                  45              


Ser Lys Ala Ala Glu Arg Thr Glu His Arg Ala Thr Arg Val Arg Tyr 
    50                  55                  60                  


Tyr Arg Ile Lys Leu Arg Lys Ile Arg Leu Leu Arg Ile Leu Ser Asp 
65                  70                  75                  80  


Asn His Leu Cys Pro Pro Leu Ser Gln Glu Glu Leu Ser Thr Trp Arg 
                85                  90                  95      


Leu Lys Lys Val Tyr Pro Lys Asn Glu Leu Phe Met Gln Trp Gln Arg 
            100                 105                 110         


Thr Asp Asp Asp Thr Glu Lys Thr Pro Tyr Ala Tyr Arg His Lys Cys 
        115                 120                 125             


Ile His Glu Lys Leu Asp Leu Ser Asp Val Thr Asp Arg Tyr Ile Leu 
    130                 135                 140                 


Gly Arg Ala Phe Tyr His Ile Ile Gln Arg Arg Gly Phe Leu Ser Asn 
145                 150                 155                 160 


Arg Lys Glu Gln Gly Gly Glu Asp Ser Gly Lys Val Lys Glu Gly Ile 
                165                 170                 175     


Ser Thr Leu Thr His Glu Met Asn Glu Ala Gly Tyr Glu Tyr Leu Gly 
            180                 185                 190         


Asp Tyr Phe Tyr Ala Leu Tyr Asn Lys Gly Glu Lys Ile Arg Lys His 
        195                 200                 205             


Tyr Thr Ala Arg Asn Glu His Phe Leu Ser Glu Phe Lys Ala Ile Cys 
    210                 215                 220                 


Glu Lys Gln Asp Leu Glu Lys Glu Leu Gly Ser Glu Val Val Arg Asn 
225                 230                 235                 240 


Ile Glu Lys Ala Ile Phe Asp Gln Arg Pro Leu Lys Ser Gln Lys Gly 
                245                 250                 255     


Gln Val Gly Lys Cys Val Phe Glu Lys Asn Lys Thr Lys Cys Pro Ser 
            260                 265                 270         


Ser His Pro Met Tyr Glu Glu Phe Arg Met Leu Thr Phe Ile Asn Asn 
        275                 280                 285             


Ile Lys Ile Lys Thr Pro Asn Asp Asp Val Leu Arg Pro Leu Asn Thr 
    290                 295                 300                 


Gly Glu Arg Glu Lys Ile Met Pro Leu Phe Phe Arg Lys Ser Lys Lys 
305                 310                 315                 320 


Gln Phe Asp Phe Glu Asp Ile Thr Lys Lys Leu Ala Pro Lys Lys Met 
                325                 330                 335     


Tyr Gly Phe Tyr Lys Lys Glu Glu Asp Ala Glu Met Pro Phe Leu Phe 
            340                 345                 350         


Asn Tyr Pro Met Asp Thr Ser Val Ser Gly Cys Pro Val Thr Ala Ala 
        355                 360                 365             


Leu Lys Asp Val Phe Gly Asp Asp Trp Ile Thr Ala Ile Cys Glu Thr 
    370                 375                 380                 


Tyr Thr Leu Gly Glu Gly Lys Ser Arg Phe Asp Ile Val Asn Asp Ile 
385                 390                 395                 400 


Trp His Ala Leu Tyr Phe Tyr Ser Asp Lys Asp Lys Leu Ala Glu Phe 
                405                 410                 415     


Ala Ile Asn Arg Leu Gln Leu Ser Glu Asp Glu Ala Lys Ile Phe Ser 
            420                 425                 430         


Glu Ile Ser Leu Pro Ala Asp Tyr Ala Ser Leu Ser Leu Lys Ala Ile 
        435                 440                 445             


Cys Lys Ile Leu Pro Tyr Leu Arg Arg Gly Leu Ile Tyr Ser His Ala 
    450                 455                 460                 


Val Phe Leu Gly Asn Leu Cys Glu Val Met Pro Lys Tyr Glu Trp Ser 
465                 470                 475                 480 


Ile Lys Glu Met Arg Glu Thr Ile Ile Asp Asn Ile Ile Met Glu Met 
                485                 490                 495     


Asp Lys Cys Asp Thr Lys Asp Lys Arg Thr Phe Glu Val Cys Ile Lys 
            500                 505                 510         


Asp Tyr Leu Lys Gly Gln Tyr Asn Val Ser Asp Asn Ser Leu Lys Lys 
        515                 520                 525             


Leu Tyr His Pro Ser Met Ile Glu Thr Tyr Pro Arg Val Gln Tyr Thr 
    530                 535                 540                 


Asn Glu His Gly Val Tyr Gln Leu Gly Ser Pro Arg Ile Asp Ser Val 
545                 550                 555                 560 


Arg Asn Pro Met Ala Met Arg Ser Met Phe Arg Leu Arg Lys Leu Val 
                565                 570                 575     


Asn Arg Leu Leu Val Glu Gly Lys Ile Asp Gln Asn Thr Glu Val His 
            580                 585                 590         


Ile Glu Phe Ala Arg Glu Leu Asn Asp Ala Asn Lys Arg Asn Ala Ile 
        595                 600                 605             


Ala Leu Phe Val Lys Glu Asn Gln Ser Ala Asn Asp Glu Ala Arg Lys 
    610                 615                 620                 


Gln Ile Ile Thr Leu Phe Lys Lys Glu Thr Gly Thr Asp Ile Glu Pro 
625                 630                 635                 640 


Thr Asp Lys Asp Ile Leu Lys Tyr Val Leu Trp Glu Glu Gln Asn His 
                645                 650                 655     


Ile Cys Leu Tyr Thr Gly Lys Gln Ile Arg Ile Ser Asp Phe Ile Gly 
            660                 665                 670         


Ala Asn Pro Lys Phe Asp Ile Glu His Thr Ile Pro Arg Ser Val Gly 
        675                 680                 685             


Gly Asp Ser Thr Lys Met Asn Leu Thr Leu Cys Asp Ser Arg Phe Asn 
    690                 695                 700                 


Arg Glu Val Lys Lys Thr Lys Leu Pro Val Glu Leu Pro Asn His Asp 
705                 710                 715                 720 


Glu Ile Met Glu Arg Ile Lys Glu Trp Lys Lys Asn Tyr Glu Leu Leu 
                725                 730                 735     


Asp Ile Gln Ile Arg Lys Asn Lys Lys Leu Ser Lys Gly Ala Thr Thr 
            740                 745                 750         


Lys Glu Gln Lys Asp Thr Ile Ile Arg Lys Arg His Leu Leu Glu Leu 
        755                 760                 765             


Arg Arg Asp Tyr Trp Arg Gly Lys Tyr Glu Arg Phe Thr Met Glu Ser 
    770                 775                 780                 


Val Pro Glu Gly Phe Ser Arg Arg Gln Gly Thr Asp Ile Ser Val Ile 
785                 790                 795                 800 


Ser Lys Tyr Ala Arg Leu Tyr Leu Lys Ser Leu Phe Asn Arg Val Tyr 
                805                 810                 815     


Thr Val Lys Gly Ile Ala Thr Ser Asp Phe Arg Lys Ile Trp Gly Ile 
            820                 825                 830         


Gln Asp Ile Tyr Ser Lys Lys Glu Arg Ile Asn His Val His His Cys 
        835                 840                 845             


Ile Asp Ala Ile Val Ile Ala Cys Ile Gly Leu Asp Glu Tyr Asn Lys 
    850                 855                 860                 


Leu Gly Ala Tyr Tyr His Asp Glu Glu Asn Asn Lys Trp Tyr Gly Met 
865                 870                 875                 880 


Ser Lys Ala Ser Phe Lys Lys Pro Trp Ala Thr Phe Val Glu Asp Ile 
                885                 890                 895     


Lys Lys Ile Gln Asp Glu Ile Leu Val Tyr His Tyr Thr Pro Asp Asn 
            900                 905                 910         


Met Pro Lys Gln Gly Arg Arg Arg Ile Lys Ile Asp Gly Lys Lys Ile 
        915                 920                 925             


Leu Cys Lys Gly Asp Ala Ala Arg Gly Ser Leu His Asn Asp Thr Tyr 
    930                 935                 940                 


Tyr Gly Ala Ile Glu Asn Asp Gly Ala Val Lys Tyr Val Lys Arg Ile 
945                 950                 955                 960 


Asp Leu Ala Ser Leu Glu Glu Lys Asp Val Lys Asn Ile Val Asp Asp 
                965                 970                 975     


Thr Val Arg Ser Ile Ile Glu Ala Ala Ile Lys Glu Lys Gly Phe Lys 
            980                 985                 990         


Asp Ala Met Ala Ser Thr Ile Trp  Met Asn Glu Glu Lys  Arg Val Pro 
        995                 1000                 1005             


Ile Lys  Lys Val Arg Cys Phe  Thr Pro Ser Ile Thr  Lys Pro Leu 
    1010                 1015                 1020             


Asn Ile  Arg Lys Gln Arg Asp  Val Ser Ile Lys Glu  Tyr Lys Gln 
    1025                 1030                 1035             


Gln Tyr  His Val Ala Asn Asp  Ser Asn Tyr Leu Leu  Ala Leu Tyr 
    1040                 1045                 1050             


Ile Gly  Thr Asp Asn Lys Gly  Lys Glu Lys Arg Glu  Phe Glu Ile 
    1055                 1060                 1065             


Val Asn  Ile Leu Gln Ala Ala  Gln Tyr Tyr Arg Thr  Ser Asn Asp 
    1070                 1075                 1080             


Lys Glu  Val Val Asp Arg His  Ile Val Pro Ile Lys  Ser Glu His 
    1085                 1090                 1095             


Asp Tyr  Pro Phe Ala Tyr Thr  Leu Lys Ile Gly Thr  Met Val Leu 
    1100                 1105                 1110             


Leu Tyr  Glu Lys Ser Pro Asn  Glu Val Trp Asp Ala  Thr Ile Lys 
    1115                 1120                 1125             


Glu Arg  Asn Arg Arg Leu Tyr  Lys Val Thr Gly Leu  Ser Thr Met 
    1130                 1135                 1140             


Arg Met  Lys Gly Arg Asn Gly  Glu Tyr Ala Tyr Ala  Thr Val Lys 
    1145                 1150                 1155             


Leu Ile  His Asn Glu Glu Ala  Arg Pro Ser Lys Asp  Ile Lys Ala 
    1160                 1165                 1170             


Lys Asn  Gly Glu Tyr Glu Gln  Gly Glu Glu Phe Arg  Pro Ala Ile 
    1175                 1180                 1185             


Ile Met  Leu His Thr Gln Leu  Asn Ala Leu Val Gln  Gly Tyr Asp 
    1190                 1195                 1200             


Phe Glu  Ile Asn Glu Leu Gly  Glu Ile Arg Arg Leu  Arg 
    1205                 1210                 1215     


<210> 402
<211> 1234
<212> PRT
<213> Prevotella tannerae


<220>
<223> Prevotella tannerae ATCC 51259

<400> 402
Met Pro Asn Phe Trp Ser Ile Phe Thr Glu Asn Leu Gln Thr Tyr Leu 
1               5                   10                  15      


Met Lys Thr Arg Ile Leu Gly Leu Asp Thr Gly Thr Asn Ser Leu Gly 
            20                  25                  30          


Trp Ala Val Val Asp Arg Asp Glu Asn Asn Gln Tyr Thr Pro Ile Cys 
        35                  40                  45              


Arg Gly Asp Leu Ile Phe Thr Glu Gly Val Lys Gln Glu Lys Gly Ile 
    50                  55                  60                  


Glu Phe Ser Leu Ala Ala Glu Arg Thr Ser Tyr Arg Ala Ser Arg Arg 
65                  70                  75                  80  


His Tyr Phe Arg Arg Arg Leu Arg Lys Val Glu Val Leu Lys Val Leu 
                85                  90                  95      


Val Lys His Lys Leu Cys Pro Pro Leu Ser Asp Glu Ala Leu Asn Arg 
            100                 105                 110         


Trp His Thr Lys Lys Glu Tyr Pro Leu Asp Glu Asp Phe Ile Leu Trp 
        115                 120                 125             


Gln Arg Thr Asn Glu Ala Asp Asn Lys Asn Pro Tyr His Asp Arg His 
    130                 135                 140                 


Ile Cys Leu His Arg Lys Leu Asn Leu Lys Asp Ser Gln Thr Asp Arg 
145                 150                 155                 160 


Tyr Thr Leu Gly Arg Ala Leu Tyr His Leu Thr Gln Arg Arg Gly Phe 
                165                 170                 175     


Leu Ser Asn Arg Leu Asp Gln Asn Glu Glu Ala Glu Glu Thr Gly Lys 
            180                 185                 190         


Val Lys Ser Ala Ile Ser Glu Leu Ser Lys Glu Met Lys Glu Ala Gly 
        195                 200                 205             


Cys Glu Phe Leu Gly Asp Tyr Phe Tyr Leu Leu Tyr Arg Thr Glu Gly 
    210                 215                 220                 


Asn Arg Val Arg Ile Arg Ser Arg Tyr Thr Asp Arg Glu Lys His Tyr 
225                 230                 235                 240 


Leu Gln Glu Phe Lys Glu Ile Cys Arg Val Gln Glu Leu Asp Glu Asp 
                245                 250                 255     


Leu Ala Lys Ala Leu Glu Lys Thr Ile Phe Phe Gln Arg Pro Leu Lys 
            260                 265                 270         


Ser Gln Arg Gln Gly Val Gly Lys Cys Thr Met Glu Lys Gly His Ser 
        275                 280                 285             


Arg Cys Ala Val Ser His Pro Leu Tyr Glu Glu Tyr Arg Leu Leu Cys 
    290                 295                 300                 


Tyr Leu Asn Asn Ile Arg Ile Lys Thr Pro Ser Asp Asp Arg Leu Arg 
305                 310                 315                 320 


Pro Leu Asn Ala Glu Glu Arg Glu Lys Ile Thr Pro Leu Phe Tyr Lys 
                325                 330                 335     


Glu Lys Asn Phe Asp Phe Glu Lys Ile Ala Lys Lys Leu Ala Gly Lys 
            340                 345                 350         


Thr Pro Phe Gly Trp Ile Arg Asp Ala Glu Asp Trp Pro Tyr Gln Phe 
        355                 360                 365             


Asn Tyr Arg Met Thr Gln Glu Ala Pro Ala Cys Pro Thr Thr Ala Gln 
    370                 375                 380                 


Leu Ile Lys Val Phe Gly Glu Asp Trp Lys Ala Ala Leu Ala Glu Thr 
385                 390                 395                 400 


Tyr Thr Met Ser Ala Lys Gln Asp Gly Thr Leu Lys Thr Glu Asp Glu 
                405                 410                 415     


Ile Cys Thr Asp Ile Trp Asn Val Leu Tyr Ser Phe Ser Ser Lys Glu 
            420                 425                 430         


Lys Leu Lys Glu Phe Gly Leu Lys Lys Leu Gln Leu Asp Glu Val Gln 
        435                 440                 445             


Ala Lys Ala Phe Ser Glu Ile Arg Leu Thr Arg Asp Phe Ala Ser Leu 
    450                 455                 460                 


Ser Leu Lys Ala Ile Arg Lys Ile Leu Phe Phe Leu Arg Thr Gly Glu 
465                 470                 475                 480 


Asp Tyr Ser Lys Ala Ile Phe Leu Ala Asn Ile Pro Thr Ile Val Gly 
                485                 490                 495     


Glu Glu Ile Trp Asn Asp Ile Glu Arg Arg Ser Arg Leu Leu Tyr Lys 
            500                 505                 510         


Val Asp Leu Ala Leu Arg Pro Gln Glu Glu Arg Asp Ala Glu Glu His 
        515                 520                 525             


Arg Thr Ile Ala Glu Arg Ile Lys Ala Ala Val Ala Ala Glu Val Pro 
    530                 535                 540                 


Asp Ala Pro Ile Asp Leu Leu Tyr His Pro Ser Met Ile Glu Ala Tyr 
545                 550                 555                 560 


Pro Asp Ala Lys Arg Asn Glu Arg Phe Asp Cys Tyr Gln Leu Gly Ser 
                565                 570                 575     


Pro Lys Thr Asn Ala Val Arg Asn Pro Met Ala Met Arg Ser Leu His 
            580                 585                 590         


Met Val Arg Lys Val Ile Asn His Leu Leu Arg Lys His Ile Ile Asp 
        595                 600                 605             


Glu Lys Thr Glu Ile His Ile Glu Tyr Ala Arg Glu Leu Asn Asp Ala 
    610                 615                 620                 


Asn Lys Arg Gln Ala Ile Ala Asp Trp Gln Arg Glu Leu Ser Lys Arg 
625                 630                 635                 640 


His Thr Ala Tyr Ala Gln Asn Ile Arg Gln Leu Tyr Lys Ala Glu Thr 
                645                 650                 655     


Gly Leu Val Ile Glu Pro Thr Lys Ala Asp Ile Leu Lys Tyr Gln Leu 
            660                 665                 670         


Trp Glu Glu Gln Gln His Val Cys Leu Tyr Thr Gly Lys Lys Ile Gly 
        675                 680                 685             


Ile Ala Asp Phe Leu Gly Ala Asn Pro Lys Phe Asp Ile Glu His Thr 
    690                 695                 700                 


Ile Pro Arg Ser Arg Gly Gly Asp Ser Thr Gln Glu Asn Leu Thr Leu 
705                 710                 715                 720 


Cys Glu Ser Lys Phe Asn Arg Asp Ile Lys Arg Asp Lys Leu Pro Thr 
                725                 730                 735     


Glu Leu Ala Asn Tyr Glu Glu Ile Leu Ala Arg Ile Glu His Trp Lys 
            740                 745                 750         


Lys Gln Cys Tyr Ala Leu Lys Leu Lys Arg Asp Gly Ile Arg Thr His 
        755                 760                 765             


Ser Gly Leu Glu Lys Ser Ile Lys Asp Ser Arg Ile Arg Arg Arg His 
    770                 775                 780                 


Leu Val Gly Leu Glu Tyr Gly Tyr Leu Lys Gly Lys Tyr Asp Arg Phe 
785                 790                 795                 800 


Thr Met Lys Glu Val Pro Glu Gly Phe Ser Arg Arg Gln Gly Ala Gly 
                805                 810                 815     


Ile Gly Leu Ile Ser Lys Tyr Ala Gly Leu Phe Leu Lys Ser Leu Phe 
            820                 825                 830         


Lys Asp Pro Lys Asn Pro Asn Arg Ser Asn Val Tyr Val Val Lys Gly 
        835                 840                 845             


Ala Ile Thr Ala Glu Phe Arg Lys Leu Trp Gly Leu Gln Gln Ala Asp 
    850                 855                 860                 


Glu Ala Lys Ser Arg Glu Asn His Thr His His Cys Ile Asp Ala Tyr 
865                 870                 875                 880 


Thr Ile Ala Cys Ile Gly Pro Cys Glu Tyr Ala Ala Leu Ala Ala Tyr 
                885                 890                 895     


Tyr Arg Ser Asp Glu Glu Phe Lys Tyr Gly Arg Arg Arg Glu Lys Pro 
            900                 905                 910         


Gln Phe Glu Lys Pro Trp Pro Thr Phe Thr Glu Asp Leu Leu Lys Leu 
        915                 920                 925             


Gln Glu Glu Leu Leu Ile Val His Gln Thr Thr Asp Lys Leu Gly Lys 
    930                 935                 940                 


Arg Asp Arg Arg Lys Val Lys Thr Pro Arg Gly Lys Phe Leu Thr Gly 
945                 950                 955                 960 


Gly Asp Ser Ala Arg Gly Arg Leu His Gln Glu Thr Tyr Tyr Gly Ala 
                965                 970                 975     


Ile Asn Tyr Asp Gly Asn Ile Lys Tyr Val Val Arg Lys Pro Leu Asp 
            980                 985                 990         


Ser Leu Thr Glu Lys Asp Leu Asp  Lys Ile Val Asp Glu  Thr Val Met 
        995                 1000                 1005             


Gly Ile  Val Lys Gly Ala Val  Glu Ala Lys Gly Ser  Leu Lys Glu 
    1010                 1015                 1020             


Ala Leu  Ala Asp Gly Ile Tyr  Met Asn Lys Glu Lys  Gly Ile Leu 
    1025                 1030                 1035             


Ile Lys  Arg Val Arg Ile Phe  Ser Asp Val Ser Glu  Pro Ile Asn 
    1040                 1045                 1050             


Leu Lys  Gln Leu Arg Asp Val  Ser Thr Lys Glu Tyr  Lys Arg His 
    1055                 1060                 1065             


Ile His  Leu Arg Lys Asp Glu  Asn Tyr Leu Phe Ala  Ile Tyr Glu 
    1070                 1075                 1080             


Gly Ile  Asp Lys Lys Lys Asn  Lys Lys Gln Thr Glu  Thr Ala Thr 
    1085                 1090                 1095             


Val Asp  Tyr Leu Asp Ala Ala  Lys Phe Tyr Lys Asp  Ser Lys Arg 
    1100                 1105                 1110             


Arg Asp  Lys Ala Asn Ser Leu  Val Gly Asp Tyr Ser  Lys Lys Asn 
    1115                 1120                 1125             


Lys Leu  Pro Leu Lys Cys Ile  Leu Lys Lys Arg Gln  Met Val Leu 
    1130                 1135                 1140             


Phe Tyr  Glu His Ser Pro Glu  Glu Ile Arg Phe Lys  Asp Lys Lys 
    1145                 1150                 1155             


Asp Leu  Ser Arg Arg Leu Tyr  Ile Val Thr Ser Ile  Ala Lys Asp 
    1160                 1165                 1170             


Gly Arg  Val Lys Phe Leu His  His Gln Ala Ala Thr  Ala Thr Gly 
    1175                 1180                 1185             


Ile Gln  Ser Ser Pro Ser Pro  Phe Thr Asn Asp Gly  Glu His Gln 
    1190                 1195                 1200             


Pro Tyr  Tyr Arg Leu Ser Ala  Ser Asn Ile Lys Val  Leu Val Ala 
    1205                 1210                 1215             


Gly Ile  Asp Phe Asp Ile Asn  Ile Leu Gly Glu Ile  Thr Pro Lys 
    1220                 1225                 1230             


Leu 
    


<210> 403
<211> 1487
<212> PRT
<213> Prevotella timonensis


<220>
<223> Prevotella timonensis CRIS 5C-B1

<400> 403
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Ser Asn Ser Val Gly Trp 
1               5                   10                  15      


Ala Leu Val Lys Val Glu Glu Asn Gly Asn Pro Ile Gly Ser Ile Lys 
            20                  25                  30          


Met Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Ile Leu Gly Ser Phe 
        35                  40                  45              


Glu Lys Gly Asp Thr Val Ser Gln Thr Ala Gln Arg Thr Leu Tyr Arg 
    50                  55                  60                  


Gly Lys Arg Arg Leu Ile Glu Arg His Val Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


Cys Arg Val Leu His Ile Met Asn Phe Leu Pro Ala His Phe Asp Arg 
                85                  90                  95      


Leu Leu Gly Trp Asp Lys Thr Asp Asn Lys Thr Tyr Gly Lys Phe Ile 
            100                 105                 110         


Asp Asp Ser Glu Pro Lys Leu Ala Trp Arg Gln Asn Lys Asn Glu Met 
        115                 120                 125             


Gly Lys Met Glu Phe Val Phe Met Asp Ser Phe His Glu Met Leu Ser 
    130                 135                 140                 


Asp Phe Ala Lys His Gln Pro Gln Leu Ile Ala Asn Gly Lys Lys Val 
145                 150                 155                 160 


Pro Leu Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Gln 
                165                 170                 175     


Leu Ile Ser Lys Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Lys 
            180                 185                 190         


Lys Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Glu Glu Glu Gln Pro 
        195                 200                 205             


Thr Lys Lys Glu Glu Tyr Lys Val Leu Lys Val Ile Ser Val Asp Ala 
    210                 215                 220                 


Asp Glu Gly Gln Lys Gly Asn Gly Ile Trp Tyr Asn Ile His Leu Glu 
225                 230                 235                 240 


Asp Gly Gly Ile Tyr Lys Lys Lys Ser Asp Ile Pro Leu Tyr Asp Trp 
                245                 250                 255     


Val Gly Lys Thr Leu Gln Leu Ile Val Val Thr Thr Tyr Glu Lys Asp 
            260                 265                 270         


Gly Lys Thr Pro Lys Ile Phe Asp Ser Gly Lys Gln Asn Pro Ser Tyr 
        275                 280                 285             


Arg Leu Pro Lys Glu Asp Asp Trp Gly Leu Val Lys Lys Arg Thr Glu 
    290                 295                 300                 


Ser Gln Leu Gln Ser Ser Gly Lys Thr Val Gly Ala Phe Ile Tyr Asp 
305                 310                 315                 320 


Asn Ile Leu Ser Lys Pro Asp Asp Lys Ile Arg Gly Asn Leu Val Arg 
                325                 330                 335     


Thr Ile Glu Arg Lys Tyr Tyr Lys Lys Glu Leu Ile Glu Ile Leu Gln 
            340                 345                 350         


Gln Gln Ala Lys Tyr His Asp Glu Leu His Asn Gln Asn Leu Leu Glu 
        355                 360                 365             


Ser Cys Ala Lys Glu Leu Tyr Ala His Asn Asp Val His Tyr Asn Glu 
    370                 375                 380                 


Val Ile Lys Ser Asn Met Ile Asn Leu Leu Val Asn Asp Ile Ile Phe 
385                 390                 395                 400 


Tyr Gln Arg Pro Leu Lys Ser Lys Lys Ser Leu Ile Ala Asn Cys Lys 
                405                 410                 415     


Tyr Glu Ser Tyr Glu Tyr Val Asp Lys Glu Thr Gly Glu Ile Lys Glu 
            420                 425                 430         


Met Pro Ile Lys Cys Ile Ala Lys Ser Asn Pro Tyr Tyr Gln Glu Phe 
        435                 440                 445             


Arg Leu Trp Gln Phe Ile His Asn Leu Arg Leu Ser Asp Val Val Thr 
    450                 455                 460                 


Arg Glu Asp Val Thr Ala Gln Tyr Leu Ser Thr Pro Gln Asp Tyr Cys 
465                 470                 475                 480 


Asn Leu Phe Thr Tyr Leu Asn Asp Arg Lys Glu Ile Lys Gln Asp Ile 
                485                 490                 495     


Leu Leu Lys Asp Phe Phe Lys Ile Lys Lys Val Gln Ile Asp Lys Glu 
            500                 505                 510         


Lys Val Phe Pro Ile Glu Trp Asn Tyr Ile Lys Asp Ala Thr Lys Ser 
        515                 520                 525             


Tyr Pro Cys Asn Glu Thr Arg Tyr Glu Leu Leu Ser Ala Leu Lys Arg 
    530                 535                 540                 


Ala Gly Met Asp Lys Gln Trp Leu Asp Asp Thr Pro Asn Met Gln Tyr 
545                 550                 555                 560 


Arg Leu Trp His Leu Leu Tyr Ser Val Glu Glu Lys Glu Glu Ser Ala 
                565                 570                 575     


Lys Ala Leu Arg Lys Leu Tyr Asp Asp Asp Lys Phe Val Thr Ser Phe 
            580                 585                 590         


Leu Lys Ile Lys Pro Phe Asn Lys Cys Tyr Gly Ala Tyr Ser Glu Lys 
        595                 600                 605             


Ala Ile Lys Arg Leu Leu Thr Leu Met Arg Met Gly Lys Ala Trp Asn 
    610                 615                 620                 


Glu Gln Ala Ile Asp Ala Lys Thr Leu Lys Cys Ile Gln Gln Ile Ile 
625                 630                 635                 640 


Thr Asp Asn Val Asp Ser Lys Leu Lys Glu Lys Ile Asp Asp Ser Arg 
                645                 650                 655     


Tyr Val Leu His His Val Ser Asp Phe Gln Gly Leu Pro Thr Tyr Leu 
            660                 665                 670         


Ala Ser Tyr Val Ile Tyr Gly Arg His Ser Glu Val Thr Asp Ile Gln 
        675                 680                 685             


Cys Trp Asp Ser Pro Glu Asp Leu Leu Lys Phe Ile Arg Asp Phe Lys 
    690                 695                 700                 


Gln His Ser Leu Arg Asn Pro Ile Val Glu Gln Val Ile Leu Glu Thr 
705                 710                 715                 720 


Leu Arg Val Val Tyr Asp Ile Trp Lys Ala Glu Lys His Ile Asp Glu 
                725                 730                 735     


Ile His Val Glu Val Ala Arg Glu Met Lys Leu Thr Ala Gln Gln Arg 
            740                 745                 750         


Asn Glu Ala Asn Leu Arg Asn Leu Asn Asn Glu Ala Thr Asn Leu Arg 
        755                 760                 765             


Ile Lys Tyr Leu Leu Glu Glu Leu Lys Asn Asp Thr Phe Ile Lys Asp 
    770                 775                 780                 


Val Arg Pro Leu Ser Pro Ile His Gln Glu Lys Met Arg Ile Tyr Glu 
785                 790                 795                 800 


Gln Ala Val Leu Gly Asn Leu Asn Lys Gln Asp Lys Asp Tyr Asp Asp 
                805                 810                 815     


Ile Ile Lys Ile Ser Lys Lys Glu His Pro Thr Asn Ala Glu Leu Ile 
            820                 825                 830         


Arg Tyr Lys Leu Trp Leu Glu Gln Arg Tyr Cys Ser Pro Tyr Thr Gly 
        835                 840                 845             


Lys Ala Ile Ser Leu Ser Lys Leu Phe Thr Thr Ala Tyr Glu Ile Glu 
    850                 855                 860                 


His Ile Ile Pro Gln Ser Arg Tyr Phe Asp Asn Ser Phe Asn Asn Lys 
865                 870                 875                 880 


Val Ile Cys Glu Ala Glu Val Asn Lys Ala Lys Gly Asn Met Leu Gly 
                885                 890                 895     


Tyr Glu Phe Ile Lys Lys Gln Gly Gly Gln Lys Ile Tyr Cys Thr Gln 
            900                 905                 910         


Leu Gly Lys Ala Val Thr Ile Leu Lys Glu Glu Ala Tyr Lys Gln Phe 
        915                 920                 925             


Val Asn Glu His Tyr Ala His Asn Lys Arg Lys Arg Asp Asn Leu Leu 
    930                 935                 940                 


Ala Glu Asn Ile Pro Glu Ser Phe Ser Ser Arg Gln Leu Asn Asp Thr 
945                 950                 955                 960 


Arg Tyr Ile Thr Lys Thr Ile Met Ser Leu Leu Ser Asn Val Val Arg 
                965                 970                 975     


Gln Gln Ser Glu Glu Glu Ala Thr Ala Lys Asn Leu Leu Pro Ser Ser 
            980                 985                 990         


Gly Ser Val Thr Asp Arg Leu Lys  Asn Asp Trp Gly Leu  Lys Asp Val 
        995                 1000                 1005             


Trp Asn  Thr Ile Val Thr Pro  Arg Phe Glu Arg Leu  Asn Lys Leu 
    1010                 1015                 1020             


Ser Gly  Thr Asn Asp Phe Gly  Glu Met Lys Glu Glu  Asn Gly Asn 
    1025                 1030                 1035             


Arg Tyr  Phe Gln Thr Asn Val  Pro Leu Glu Tyr Glu  Lys Gly Phe 
    1040                 1045                 1050             


Lys Lys  Lys Arg Ile Asp His  Arg His His Ala Met  Asp Ala Leu 
    1055                 1060                 1065             


Val Ile  Ala Cys Thr Thr Arg  Asn Met Val Asn Tyr  Ile Ser Asn 
    1070                 1075                 1080             


Ala Asn  Ala Asn Ser Pro Lys  Gln Arg Glu Asp Leu  Arg Gln Leu 
    1085                 1090                 1095             


Leu Cys  Asp Lys Asn Arg Ile  Ile Asn Lys Pro Trp  Asp Thr Phe 
    1100                 1105                 1110             


Thr Gln  Asp Ala Leu Lys Ala  Leu Asn Asp Ile Val  Val Ser Phe 
    1115                 1120                 1125             


Lys Asn  Asn Val Arg Ile Ile  Asn Arg Ala Thr Asn  Arg Tyr Gln 
    1130                 1135                 1140             


Arg Tyr  Asp Lys Asn Gly Lys  Lys Ile Ile Phe Ser  Gln Lys Gly 
    1145                 1150                 1155             


Asp Asp  Met Trp Ala Ile Arg  Lys Ser Met His Lys  Glu Thr Val 
    1160                 1165                 1170             


Phe Gly  Arg Val Asn Leu Ile  Arg Lys Glu Val Leu  Pro Ile Ala 
    1175                 1180                 1185             


Lys Ala  Leu Asp Asn Ile Ser  Ala Ile Cys Asn Ala  Gln Leu Arg 
    1190                 1195                 1200             


Ala Tyr  Val Asn Asp Leu Val  Asp Lys His Phe Asn  Lys Lys Gln 
    1205                 1210                 1215             


Leu Val  Ala His Phe Lys Ser  Leu Asn Tyr Lys Trp  Asn Arg Gln 
    1220                 1225                 1230             


Asp Val  Ser Lys Val Glu Val  Trp Ile Ser Ser Asp  Asn Lys Thr 
    1235                 1240                 1245             


Pro Met  Val Ala Val Arg Lys  Pro Leu Asp Thr Ser  Phe Asp Lys 
    1250                 1255                 1260             


Lys Lys  Ile Ala Ser Ile Thr  Asp Thr Gly Ile Gln  Thr Ile Leu 
    1265                 1270                 1275             


Leu Asn  Tyr Leu Glu Ser Lys  Gly Gly Asp Ala Ser  Val Ala Phe 
    1280                 1285                 1290             


Ala Pro  Glu Gly Ile Gln Glu  Met Asn Ser Asn Ile  Glu Leu Tyr 
    1295                 1300                 1305             


Asn Asn  Gly Lys Ala His Lys  Pro Ile Lys Asn Val  Arg Leu Ser 
    1310                 1315                 1320             


Glu Pro  Leu Gly Ala Lys Tyr  Gln Val Gly Glu Arg  Gly Ala Lys 
    1325                 1330                 1335             


Thr Lys  Lys Tyr Val Glu Ala  Asp Lys Gly Thr Asn  Leu Phe Phe 
    1340                 1345                 1350             


Ala Ile  Tyr Glu Asp Glu Glu  Gly Lys Arg Tyr Tyr  Tyr Ser Val 
    1355                 1360                 1365             


Pro Leu  Arg Glu Ala Ile Glu  Arg Gln Lys Gln Lys  Leu Ser Pro 
    1370                 1375                 1380             


Val Pro  Glu Tyr Asn Glu Lys  Gly Val Ala Leu Lys  Phe Tyr Leu 
    1385                 1390                 1395             


Ser Pro  Asn Asp Leu Val Tyr  Val Pro Thr Glu Glu  Glu Arg Thr 
    1400                 1405                 1410             


Met Gly  Thr Cys His Ile Asp  Lys Ala Arg Ile Tyr  Lys Met Val 
    1415                 1420                 1425             


Ser Ser  Thr Gly Cys Ser Cys  Tyr Phe Val Pro Ser  Thr Phe Ala 
    1430                 1435                 1440             


Lys Val  Ile Val Asp Lys Val  Glu Leu Gln Ser Leu  Asn Lys Met 
    1445                 1450                 1455             


Glu Lys  Ala Ile Thr Asp Glu  Cys Ile Lys Glu Val  Cys Trp Lys 
    1460                 1465                 1470             


Leu Lys  Val Asp Arg Leu Gly  Asn Ile Ile Asn Val  Ile Lys 
    1475                 1480                 1485         


<210> 404
<211> 1218
<212> PRT
<213> Prevotella timonensis


<220>
<223> Prevotella timonensis CRIS 5C-B1

<400> 404
Met Asn Lys Arg Ile Leu Gly Leu Asp Thr Gly Thr Asn Ser Leu Gly 
1               5                   10                  15      


Trp Ala Val Val Asp Trp Asp Glu His Ala Gln Ser Tyr Glu Leu Ile 
            20                  25                  30          


Lys Tyr Gly Asp Val Ile Phe Gln Glu Gly Val Lys Ile Glu Lys Gly 
        35                  40                  45              


Ile Glu Ser Ser Lys Ala Ala Glu Arg Ser Gly Tyr Lys Ala Ile Arg 
    50                  55                  60                  


Lys Gln Tyr Phe Arg Arg Arg Leu Arg Lys Ile Gln Val Leu Lys Val 
65                  70                  75                  80  


Leu Val Lys Tyr His Leu Cys Pro Tyr Leu Ser Asp Asp Asp Leu Arg 
                85                  90                  95      


Gln Trp His Leu Gln Lys Gln Tyr Pro Lys Ser Asp Glu Leu Met Leu 
            100                 105                 110         


Trp Gln Arg Thr Ser Asp Glu Glu Gly Lys Asn Pro Tyr Tyr Asp Arg 
        115                 120                 125             


His Arg Cys Leu His Glu Lys Leu Asp Leu Thr Val Glu Ala Asp Arg 
    130                 135                 140                 


Tyr Thr Leu Gly Arg Ala Leu Tyr His Leu Thr Gln Arg Arg Gly Phe 
145                 150                 155                 160 


Leu Ser Asn Arg Leu Asp Thr Ser Ala Asp Asn Lys Glu Asp Gly Val 
                165                 170                 175     


Val Lys Ser Gly Ile Ser Gln Leu Ser Thr Glu Met Glu Glu Ala Gly 
            180                 185                 190         


Cys Glu Tyr Leu Gly Asp Tyr Phe Tyr Lys Leu Tyr Asp Ala Gln Gly 
        195                 200                 205             


Asn Lys Val Arg Ile Arg Gln Arg Tyr Thr Asp Arg Asn Lys His Tyr 
    210                 215                 220                 


Gln His Glu Phe Asp Ala Ile Cys Glu Lys Gln Glu Leu Ser Ser Glu 
225                 230                 235                 240 


Leu Ile Glu Asp Leu Gln Arg Ala Ile Phe Phe Gln Leu Pro Leu Lys 
                245                 250                 255     


Ser Gln Arg His Gly Val Gly Arg Cys Thr Phe Glu Arg Gly Lys Pro 
            260                 265                 270         


Arg Cys Ala Asp Ser His Pro Asp Tyr Glu Glu Phe Arg Met Leu Cys 
        275                 280                 285             


Phe Val Asn Asn Ile Gln Val Lys Gly Pro His Asp Leu Glu Leu Arg 
    290                 295                 300                 


Pro Leu Thr Tyr Glu Glu Arg Glu Lys Ile Glu Pro Leu Phe Phe Arg 
305                 310                 315                 320 


Lys Ser Lys Pro Asn Phe Asp Phe Glu Asp Ile Ala Lys Ala Leu Ala 
                325                 330                 335     


Gly Lys Lys Asn Tyr Ala Trp Ile His Asp Lys Glu Glu Arg Ala Tyr 
            340                 345                 350         


Lys Phe Asn Tyr Arg Met Thr Gln Gly Val Pro Gly Cys Pro Thr Ile 
        355                 360                 365             


Ala Gln Leu Lys Ser Ile Phe Gly Asp Asp Trp Lys Thr Gly Ile Ala 
    370                 375                 380                 


Glu Thr Tyr Thr Leu Ile Gln Lys Lys Asn Gly Ser Lys Ser Leu Gln 
385                 390                 395                 400 


Glu Met Val Asp Asp Val Trp Asn Val Leu Tyr Ser Phe Ser Ser Val 
                405                 410                 415     


Glu Lys Leu Lys Glu Phe Ala His His Lys Leu Gln Leu Asp Glu Glu 
            420                 425                 430         


Ser Ala Glu Lys Phe Ala Lys Ile Lys Leu Ser His Ser Phe Ala Ala 
        435                 440                 445             


Leu Ser Leu Lys Ala Ile Arg Lys Phe Leu Pro Phe Leu Arg Lys Gly 
    450                 455                 460                 


Met Tyr Tyr Thr His Ala Ser Phe Phe Ala Asn Ile Pro Thr Ile Val 
465                 470                 475                 480 


Gly Lys Glu Ile Trp Asn Lys Glu Gln Asn Arg Lys Tyr Ile Met Glu 
                485                 490                 495     


Asn Val Gly Glu Leu Val Phe Asn Tyr Gln Pro Lys His Arg Glu Val 
            500                 505                 510         


Gln Gly Thr Ile Glu Met Leu Ile Lys Asp Phe Leu Ala Asn Asn Phe 
        515                 520                 525             


Glu Leu Pro Ala Gly Ala Thr Asp Lys Leu Tyr His Pro Ser Met Ile 
    530                 535                 540                 


Glu Thr Tyr Pro Asn Ala Gln Arg Asn Glu Phe Gly Ile Leu Gln Leu 
545                 550                 555                 560 


Gly Ser Pro Arg Thr Asn Ala Ile Arg Asn Pro Met Ala Met Arg Ser 
                565                 570                 575     


Leu His Ile Leu Arg Arg Val Val Asn Gln Leu Leu Lys Glu Ser Ile 
            580                 585                 590         


Ile Asp Glu Asn Thr Glu Val His Val Glu Tyr Ala Arg Glu Leu Asn 
        595                 600                 605             


Asp Ala Asn Lys Arg Arg Ala Ile Ala Asp Arg Gln Lys Glu Gln Asp 
    610                 615                 620                 


Lys Gln His Lys Lys Tyr Gly Asp Glu Ile Arg Lys Leu Tyr Lys Glu 
625                 630                 635                 640 


Glu Thr Gly Lys Asp Ile Glu Pro Thr Gln Thr Asp Val Leu Lys Phe 
                645                 650                 655     


Gln Leu Trp Glu Glu Gln Asn His His Cys Leu Tyr Thr Gly Glu Gln 
            660                 665                 670         


Ile Gly Ile Thr Asp Phe Ile Gly Ser Asn Pro Lys Phe Asp Ile Glu 
        675                 680                 685             


His Thr Ile Pro Gln Ser Val Gly Gly Asp Ser Thr Gln Met Asn Leu 
    690                 695                 700                 


Thr Leu Cys Asp Asn Arg Phe Asn Arg Glu Val Lys Lys Ala Lys Leu 
705                 710                 715                 720 


Pro Thr Glu Leu Ala Asn His Glu Glu Ile Leu Thr Arg Ile Glu Pro 
                725                 730                 735     


Trp Lys Asn Lys Tyr Glu Gln Leu Val Lys Glu Arg Asp Lys Gln Arg 
            740                 745                 750         


Thr Phe Ala Gly Met Asp Lys Ala Val Lys Asp Ile Arg Ile Gln Lys 
        755                 760                 765             


Arg His Lys Leu Gln Met Glu Ile Asp Tyr Trp Arg Gly Lys Tyr Glu 
    770                 775                 780                 


Arg Phe Thr Met Thr Glu Val Pro Glu Gly Phe Ser Arg Arg Gln Gly 
785                 790                 795                 800 


Thr Gly Ile Gly Leu Ile Ser Arg Tyr Ala Gly Leu Tyr Leu Lys Ser 
                805                 810                 815     


Leu Phe His Gln Ala Asp Ser Arg Asn Lys Ser Asn Val Tyr Val Val 
            820                 825                 830         


Lys Gly Val Ala Thr Ala Glu Phe Arg Lys Met Trp Gly Leu Gln Ser 
        835                 840                 845             


Glu Tyr Glu Lys Lys Cys Arg Asp Asn His Ser His His Cys Met Asp 
    850                 855                 860                 


Ala Ile Thr Ile Ala Cys Ile Gly Lys Arg Glu Tyr Asp Leu Met Ala 
865                 870                 875                 880 


Glu Tyr Tyr Arg Met Glu Glu Thr Phe Lys Gln Gly Arg Gly Ser Lys 
                885                 890                 895     


Pro Lys Phe Ser Lys Pro Trp Ala Thr Phe Thr Glu Asp Val Leu Asn 
            900                 905                 910         


Ile Tyr Lys Asn Leu Leu Val Val His Asp Thr Pro Asn Asn Met Pro 
        915                 920                 925             


Lys His Thr Lys Lys Tyr Val Gln Thr Ser Ile Gly Lys Val Leu Ala 
    930                 935                 940                 


Gln Gly Asp Thr Ala Arg Gly Ser Leu His Leu Asp Thr Tyr Tyr Gly 
945                 950                 955                 960 


Ala Ile Glu Arg Asp Gly Glu Ile Arg Tyr Val Val Arg Arg Pro Leu 
                965                 970                 975     


Ser Ser Phe Thr Lys Pro Glu Glu Leu Glu Asn Ile Val Asp Glu Thr 
            980                 985                 990         


Val Lys Arg Thr Ile Lys Glu Ala  Ile Ala Asp Lys Asn  Phe Lys Gln 
        995                 1000                 1005             


Ala Ile  Ala Glu Pro Ile Tyr  Met Asn Glu Glu Lys  Gly Ile Leu 
    1010                 1015                 1020             


Ile Lys  Lys Val Arg Cys Phe  Ala Lys Ser Val Lys  Gln Pro Ile 
    1025                 1030                 1035             


Asn Ile  Arg Gln His Arg Asp  Leu Ser Lys Lys Glu  Tyr Lys Gln 
    1040                 1045                 1050             


Gln Tyr  His Val Met Asn Glu  Asn Asn Tyr Leu Leu  Ala Ile Tyr 
    1055                 1060                 1065             


Glu Gly  Leu Val Lys Asn Lys  Val Val Arg Glu Phe  Glu Ile Val 
    1070                 1075                 1080             


Ser Tyr  Ile Glu Ala Ala Lys  Tyr Tyr Lys Arg Ser  Gln Asp Arg 
    1085                 1090                 1095             


Asn Ile  Phe Ser Ser Ile Val  Pro Thr His Ser Thr  Lys Tyr Gly 
    1100                 1105                 1110             


Leu Pro  Leu Lys Thr Lys Leu  Leu Met Gly Gln Leu  Val Leu Met 
    1115                 1120                 1125             


Phe Glu  Glu Asn Pro Asp Glu  Ile Gln Val Asp Asn  Thr Lys Asp 
    1130                 1135                 1140             


Leu Val  Lys Arg Leu Tyr Lys  Val Val Gly Ile Glu  Lys Asp Gly 
    1145                 1150                 1155             


Arg Ile  Lys Phe Lys Tyr His  Gln Glu Ala Arg Lys  Glu Gly Leu 
    1160                 1165                 1170             


Pro Ile  Phe Ser Thr Pro Tyr  Lys Asn Asn Asp Asp  Tyr Ala Pro 
    1175                 1180                 1185             


Ile Phe  Arg Gln Ser Ile Asn  Asn Ile Asn Ile Leu  Val Asp Gly 
    1190                 1195                 1200             


Ile Asp  Phe Thr Ile Asp Ile  Leu Gly Lys Val Thr  Leu Lys Glu 
    1205                 1210                 1215             


<210> 405
<211> 1496
<212> PRT
<213> Prevotella veroralis


<220>
<223> Prevotella veroralis F0319

<400> 405
Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Lys Val Cys Val Asp Asp Asn Gly Asn Tyr Leu Arg Asp Ile Lys 
            20                  25                  30          


Leu Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Val Leu Gly Asn Phe 
        35                  40                  45              


Asp Lys Gly Val Thr Glu Ser Gln Thr Ser Val Arg Thr Gly Phe Arg 
    50                  55                  60                  


Gly Val Arg Arg Ile Arg Glu Arg Ser Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu His Val Leu Gly Tyr Leu Pro Pro His Tyr Asp Ser 
                85                  90                  95      


Ala Ile Gly Trp Asn Lys Asn Glu Pro Ser Thr Tyr Gly Lys Phe Leu 
            100                 105                 110         


Asn His Gly Glu Pro Lys Leu Ala Trp Glu His Lys Glu Asp Gly Ser 
        115                 120                 125             


Met Arg Phe Leu Phe Met Glu Ser Phe His Glu Met Met Ala Asp Phe 
    130                 135                 140                 


Ala Lys Ser Gln Pro Ser Leu Val Ser Asp Gly Lys Lys Ile Pro Leu 
145                 150                 155                 160 


Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Gln Pro Ile 
                165                 170                 175     


Arg Lys Glu Glu Leu Ala Trp Leu Leu Leu Asn Phe Asn Gln Lys Arg 
            180                 185                 190         


Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Asp Asp Asp Asn Pro Thr Lys 
        195                 200                 205             


Cys Glu Glu Tyr Tyr Glu Leu Lys Val Val Gly Ile Glu Ala Asp Glu 
    210                 215                 220                 


Glu Gly Lys Asn Gly Asn Thr Trp Tyr Asn Val Lys Leu Glu Asn Gly 
225                 230                 235                 240 


Trp Ile Tyr Arg Arg Gln Ser Lys Ile Pro Leu Asp Asp Trp Ile Gly 
                245                 250                 255     


Lys Val Arg Glu Phe Ile Val Thr Thr Glu Tyr Glu Lys Asp Gly Ile 
            260                 265                 270         


Thr Leu Lys Lys Asp Lys Asn Gly Asp Val Lys Arg Ser Phe Arg Ser 
        275                 280                 285             


Pro Ser Glu Asp Asp Trp Gly Leu Arg Lys Lys Arg Thr Glu Lys Leu 
    290                 295                 300                 


Leu Asp Ser Ser Lys Met Thr Val Gly Ala Phe Val Tyr Asp His Leu 
305                 310                 315                 320 


Leu Ala Glu Pro Ser Asp Lys Ile Arg Gly Lys Phe Ile Arg Thr Ile 
                325                 330                 335     


Glu Arg Lys Tyr Tyr Lys Lys Glu Leu Tyr Ala Ile Leu Cys Glu Gln 
            340                 345                 350         


Ser Lys Tyr His Glu Glu Leu Arg Ser Gly Asp Tyr Leu Asn Lys Cys 
        355                 360                 365             


Ala Glu Glu Leu Tyr Lys Asn Asn Gln Pro His Arg Asn Ser Leu Leu 
    370                 375                 380                 


Thr Lys Asp Leu Ala Tyr Leu Leu Leu Glu Asp Leu Ile Phe Tyr Gln 
385                 390                 395                 400 


Arg Pro Leu Lys Thr Lys Lys Ser Leu Ile Ala Glu Cys Pro Tyr Glu 
                405                 410                 415     


Ala Tyr Lys Tyr Val Asp Lys Glu Thr Gly Glu Ile Lys Arg Gln Gly 
            420                 425                 430         


Ile Lys Cys Ile Ala Lys Ser Asn Pro Tyr Tyr Gln Glu Phe Arg Leu 
        435                 440                 445             


Trp Gln Phe Ile Ser Asn Leu Arg Leu Phe Asn Lys Ala Asp Asp Lys 
    450                 455                 460                 


Glu Val Thr Ala Asp Tyr Leu Pro Thr Gln Asp Asp Tyr Val Arg Leu 
465                 470                 475                 480 


Phe Ala Tyr Leu Asn Asp Arg Lys Glu Ile Asn Gln Glu Thr Leu Leu 
                485                 490                 495     


Lys Glu Phe Phe Lys Leu Lys Lys Ile Thr Val Asn Ser Glu Lys Val 
            500                 505                 510         


Phe Pro Ile Arg Trp Asn Tyr Ile Glu Asp Lys Glu Lys Lys Tyr Pro 
        515                 520                 525             


Cys Asn Glu Thr Arg His Glu Leu Leu Leu Ala Leu Asp Arg Ala Arg 
    530                 535                 540                 


Ile Asp His Ser Trp Leu Glu Lys Pro Gly Gln Glu Tyr Arg Leu Trp 
545                 550                 555                 560 


His Leu Leu Tyr Ser Val Glu Ser Lys Glu Glu Thr Lys Glu Ala Leu 
                565                 570                 575     


Arg Lys Leu Lys Asp Asp Asp Ala Phe Val Glu Ser Phe Leu Lys Val 
            580                 585                 590         


Lys Pro Phe Lys Arg Glu Tyr Gly Ala Tyr Ser Glu Lys Ala Ile Lys 
        595                 600                 605             


Lys Leu Leu Ala Val Met Arg Met Gly Ser Leu Trp Arg Glu Thr Asp 
    610                 615                 620                 


Ile Cys Asp Thr Thr Lys Gly Asn Ile Thr Lys Ile Leu Gln Gly Glu 
625                 630                 635                 640 


Ile Asp Glu Lys Leu Lys Glu Lys Ile Ser Ala Ser Val Ser Ser Tyr 
                645                 650                 655     


Asn Gln Leu Ser Asp Phe Gln Gly Leu Pro Val Trp Leu Ala Cys Tyr 
            660                 665                 670         


Val Val Tyr Gly Arg His Ser Glu Ala Ala Glu Ile Gln His Trp Lys 
        675                 680                 685             


Thr Pro Glu Ser Leu Leu Ala Tyr Ile Asn Gly Phe Lys Gln His Ser 
    690                 695                 700                 


Leu Arg Asn Pro Ile Val Glu Gln Cys Ile Leu Glu Thr Leu Arg Thr 
705                 710                 715                 720 


Val His Asp Ile Trp Lys Glu Val Gly His Ile Asp Glu Ile His Val 
                725                 730                 735     


Glu Leu Gly Arg Asn Met Lys Ser Thr Ala Asp Gln Arg Ala Arg Ile 
            740                 745                 750         


Ser Glu Asn Val Leu Arg Asn Glu Asn Thr Asn Leu Arg Ile Lys Ser 
        755                 760                 765             


Leu Leu Leu Glu Leu Lys Asn Asp Pro Asn Ile Lys Asp Val Arg Pro 
    770                 775                 780                 


Tyr Ser Pro Met Gln Gln Glu Lys Leu Arg Ile Tyr Glu Glu Gly Val 
785                 790                 795                 800 


Leu Gln Glu Leu Thr Lys Asp Asp Lys Asp Phe Thr Glu Ile Thr Lys 
                805                 810                 815     


Ile Ser Thr Met Ala Gln Pro Ser Ala Lys Glu Leu Gln Arg Tyr Lys 
            820                 825                 830         


Leu Trp Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Lys Ser Ile 
        835                 840                 845             


Ser Leu Thr Lys Leu Phe Thr Ser Ala Tyr Gln Ile Glu His Val Ile 
    850                 855                 860                 


Pro Gln Ser Arg Tyr Phe Asp Asp Ser Phe Ser Asn Lys Val Ile Cys 
865                 870                 875                 880 


Glu Ser Glu Val Asn Ser Leu Lys Asp Asn Met Leu Gly Tyr Glu Phe 
                885                 890                 895     


Ile Lys Asn His Gly Gly Glu Ile Ile His Cys Thr Met Leu Gly Asp 
            900                 905                 910         


Val Lys Val Leu Ser Glu Ser Glu Tyr Lys Ala Phe Val Asn Asp His 
        915                 920                 925             


Tyr Ala His Asn Lys Arg Lys Arg Glu Asn Leu Leu Leu Glu Asp Ile 
    930                 935                 940                 


Pro Gln Glu Phe Leu Asn Arg Gln Met Asn Asp Ser Arg Tyr Ile Ser 
945                 950                 955                 960 


Lys Val Val Lys Ala Leu Leu Ser Asn Ile Val Arg Ala Glu Gly Glu 
                965                 970                 975     


Glu Glu Ala Thr Ser Lys Phe Val Val Ser Cys Ser Gly Gly Ile Thr 
            980                 985                 990         


Asp Arg Leu Lys Lys Asp Trp Gly  Leu Asn Asp Val Trp  Asn Lys Ile 
        995                 1000                 1005             


Val Tyr  Pro Arg Phe Glu Arg  Leu Asn Arg Leu Thr  Gly Thr Glu 
    1010                 1015                 1020             


Ala Phe  Gly Gln Trp Glu Asn  Lys Asp Gly Lys Arg  Val Phe Gln 
    1025                 1030                 1035             


Thr Ala  Val Pro Leu Glu Leu  Gln Arg Gly Phe Asn  Lys Lys Arg 
    1040                 1045                 1050             


Ile Asp  His Arg His His Ala  Met Asp Ala Leu Val  Ile Ala Cys 
    1055                 1060                 1065             


Thr Ser  Arg Asn Ile Ile Asn  Tyr Leu Asn Asn Glu  Ser Ala Asn 
    1070                 1075                 1080             


Asn Pro  Lys Lys Arg Glu Asp  Leu Arg Gln Lys Leu  Cys Asp Lys 
    1085                 1090                 1095             


Asn Arg  Thr Ile Arg Lys Pro  Trp Glu Thr Phe Thr  Gln Asp Ala 
    1100                 1105                 1110             


Thr Ala  Ala Leu Glu Asp Val  Ile Val Ser Phe Lys  Asn Tyr Val 
    1115                 1120                 1125             


Arg Ile  Ile Asn Lys Ala Thr  Asn Tyr Tyr Glu Arg  Tyr Asp Val 
    1130                 1135                 1140             


Glu Gly  Lys Lys Val Ile Ala  Glu Gln Arg Gly Asp  Asp Met Trp 
    1145                 1150                 1155             


Ala Ile  Arg Lys Pro Met His  Glu Ala Thr Tyr Tyr  Gly Arg Val 
    1160                 1165                 1170             


Asn Leu  Arg Arg Lys Lys Lys  Val Asn Leu Arg Val  Ala Leu Glu 
    1175                 1180                 1185             


Asn Ile  Ser Ser Ile Cys Asp  Asn Lys Leu Arg Ile  Tyr Ile Asn 
    1190                 1195                 1200             


Gly Leu  Val Glu Lys Gly Phe  Asn Thr Lys Gln Ile  Leu Asp Lys 
    1205                 1210                 1215             


Phe Lys  Asn Thr Asn Asp His  Phe Ser Met Gln Lys  Ile Asp Lys 
    1220                 1225                 1230             


Val Glu  Ile Trp Gln Phe Thr  Asn Glu Glu Glu Lys  Leu Val Ala 
    1235                 1240                 1245             


Thr Arg  Lys Pro Leu Asp Thr  Ser Phe Asp Thr Lys  Lys Ile Ala 
    1250                 1255                 1260             


Ser Ile  Thr Asp Thr Gly Ile  Gln Thr Ile Leu Leu  Asn Tyr Leu 
    1265                 1270                 1275             


Glu Thr  Lys Gly Gly Asp Ser  Thr Ile Ala Phe Thr  Pro Glu Gly 
    1280                 1285                 1290             


Ile Val  Glu Met Asn Gln Asn  Ile Ser Lys Tyr Asn  Asn Gly Lys 
    1295                 1300                 1305             


Glu His  Met Pro Ile Leu Lys  Val Arg Leu Tyr Thr  Lys Leu Gly 
    1310                 1315                 1320             


Lys Lys  Ile Pro Val Gly Gln  Thr Gly Cys Lys Ala  Lys Gln Phe 
    1325                 1330                 1335             


Val Ile  Ala Glu Ala Gly Thr  Asn Leu Tyr Phe Ala  Ile Tyr Glu 
    1340                 1345                 1350             


Asp Glu  Glu Gly Lys Arg Ser  Tyr Arg Thr Ile Pro  Leu Asn Glu 
    1355                 1360                 1365             


Val Val  Glu Arg Leu Lys Gln  Gly Leu Ser Pro Val  Pro Glu Lys 
    1370                 1375                 1380             


Asn Asp  Lys Asp Val His Leu  Lys Phe Tyr Leu Ser  Pro Asn Asp 
    1385                 1390                 1395             


Leu Val  Tyr Val Pro Ile Glu  Asp Glu His Glu Ser  Leu Ala Lys 
    1400                 1405                 1410             


Asp His  Ile Tyr Lys Phe Val  Asp Ser Ser Gly Thr  Thr Ala Asn 
    1415                 1420                 1425             


Phe Ile  Pro His Arg Ser Ala  Asn Val Ile Phe Glu  Leu Asn Lys 
    1430                 1435                 1440             


Lys Asp  Ala Glu Lys Phe Cys  Ser Gly Ser Ile Ile  Gln Asn Glu 
    1445                 1450                 1455             


Tyr Gly  Val Gly Ser Ser Gln  Ser Lys Asn Gln Lys  Ala Ile Thr 
    1460                 1465                 1470             


Gly Glu  Met Ile Lys Ala Val  Cys Arg Lys Leu Glu  Val Asp Arg 
    1475                 1480                 1485             


Leu Gly  Asn Val Ile Lys Val  Ile 
    1490                 1495     


<210> 406
<211> 1062
<212> PRT
<213> Ralstonia syzygii


<220>
<223> Ralstonia syzygii R24

<400> 406
Met Ala Glu Lys Gln His Arg Trp Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Ile Gly Trp Ala Val Ile Ala Leu Ile Glu Gly Arg Pro Ala Gly Leu 
            20                  25                  30          


Val Ala Thr Gly Ser Arg Ile Phe Ser Asp Gly Arg Asn Pro Lys Asp 
        35                  40                  45              


Gly Ser Ser Leu Ala Val Glu Arg Arg Gly Pro Arg Gln Met Arg Arg 
    50                  55                  60                  


Arg Arg Asp Arg Tyr Leu Arg Arg Arg Asp Arg Phe Met Gln Ala Leu 
65                  70                  75                  80  


Ile Asn Val Gly Leu Met Pro Gly Asp Ala Ala Ala Arg Lys Ala Leu 
                85                  90                  95      


Val Thr Glu Asn Pro Tyr Val Leu Arg Gln Arg Gly Leu Asp Gln Ala 
            100                 105                 110         


Leu Thr Leu Pro Glu Phe Gly Arg Ala Leu Phe His Leu Asn Gln Arg 
        115                 120                 125             


Arg Gly Phe Gln Ser Asn Arg Lys Thr Asp Arg Ala Thr Ala Lys Glu 
    130                 135                 140                 


Ser Gly Lys Val Lys Asn Ala Ile Ala Ala Phe Arg Ala Gly Met Gly 
145                 150                 155                 160 


Asn Ala Arg Thr Val Gly Glu Ala Leu Ala Arg Arg Leu Glu Asp Gly 
                165                 170                 175     


Arg Pro Val Arg Ala Arg Met Val Gly Gln Gly Lys Asp Glu His Tyr 
            180                 185                 190         


Glu Leu Tyr Ile Ala Arg Glu Trp Ile Ala Gln Glu Phe Asp Ala Leu 
        195                 200                 205             


Trp Ala Ser Gln Gln Arg Phe His Ala Glu Val Leu Ala Asp Ala Ala 
    210                 215                 220                 


Arg Asp Arg Leu Arg Ala Ile Leu Leu Phe Gln Arg Lys Leu Leu Pro 
225                 230                 235                 240 


Val Pro Val Gly Lys Cys Phe Leu Glu Pro Asn Gln Pro Arg Val Ala 
                245                 250                 255     


Ala Ala Leu Pro Ser Ala Gln Arg Phe Arg Leu Met Gln Glu Leu Asn 
            260                 265                 270         


His Leu Arg Val Met Thr Leu Ala Asp Lys Arg Glu Arg Pro Leu Ser 
        275                 280                 285             


Phe Gln Glu Arg Asn Asp Leu Leu Ala Gln Leu Val Ala Arg Pro Lys 
    290                 295                 300                 


Cys Gly Phe Asp Met Leu Arg Lys Ile Val Phe Gly Ala Asn Lys Glu 
305                 310                 315                 320 


Ala Tyr Arg Phe Thr Ile Glu Ser Glu Arg Arg Lys Glu Leu Lys Gly 
                325                 330                 335     


Cys Asp Thr Ala Ala Lys Leu Ala Lys Val Asn Ala Leu Gly Thr Arg 
            340                 345                 350         


Trp Gln Ala Leu Ser Leu Asp Glu Gln Asp Arg Leu Val Cys Leu Leu 
        355                 360                 365             


Leu Asp Gly Glu Asn Asp Ala Val Leu Ala Asp Ala Leu Arg Glu His 
    370                 375                 380                 


Tyr Gly Leu Thr Asp Ala Gln Ile Asp Thr Leu Leu Gly Leu Ser Phe 
385                 390                 395                 400 


Glu Asp Gly His Met Arg Leu Gly Arg Ser Ala Leu Leu Arg Val Leu 
                405                 410                 415     


Asp Ala Leu Glu Ser Gly Arg Asp Glu Gln Gly Leu Pro Leu Ser Tyr 
            420                 425                 430         


Asp Lys Ala Val Val Ala Ala Gly Tyr Pro Ala His Thr Ala Asp Leu 
        435                 440                 445             


Glu Asn Gly Glu Arg Asp Ala Leu Pro Tyr Tyr Gly Glu Leu Leu Trp 
    450                 455                 460                 


Arg Tyr Thr Gln Asp Ala Pro Thr Ala Lys Asn Asp Ala Glu Arg Lys 
465                 470                 475                 480 


Phe Gly Lys Ile Ala Asn Pro Thr Val His Ile Gly Leu Asn Gln Leu 
                485                 490                 495     


Arg Lys Leu Val Asn Ala Leu Ile Gln Arg Tyr Gly Lys Pro Ala Gln 
            500                 505                 510         


Ile Val Val Glu Leu Ala Arg Asn Leu Lys Ala Gly Leu Glu Glu Lys 
        515                 520                 525             


Glu Arg Ile Lys Lys Gln Gln Thr Ala Asn Leu Glu Arg Asn Glu Arg 
    530                 535                 540                 


Ile Arg Gln Lys Leu Gln Asp Ala Gly Val Pro Asp Asn Arg Glu Asn 
545                 550                 555                 560 


Arg Leu Arg Met Arg Leu Phe Glu Glu Leu Gly Gln Gly Asn Gly Leu 
                565                 570                 575     


Gly Thr Pro Cys Ile Tyr Ser Gly Arg Gln Ile Ser Leu Gln Arg Leu 
            580                 585                 590         


Phe Ser Asn Asp Val Gln Val Asp His Ile Leu Pro Phe Ser Lys Thr 
        595                 600                 605             


Leu Asp Asp Ser Phe Ala Asn Lys Val Leu Ala Gln His Asp Ala Asn 
    610                 615                 620                 


Arg Tyr Lys Gly Asn Arg Gly Pro Phe Glu Ala Phe Gly Ala Asn Arg 
625                 630                 635                 640 


Asp Gly Tyr Ala Trp Asp Asp Ile Arg Ala Arg Ala Ala Val Leu Pro 
                645                 650                 655     


Arg Asn Lys Arg Asn Arg Phe Ala Glu Thr Ala Met Gln Asp Trp Leu 
            660                 665                 670         


His Asn Glu Thr Asp Phe Leu Ala Arg Gln Leu Thr Asp Thr Ala Tyr 
        675                 680                 685             


Leu Ser Arg Val Ala Arg Gln Tyr Leu Thr Ala Ile Cys Ser Lys Asp 
    690                 695                 700                 


Asp Val Tyr Val Ser Pro Gly Arg Leu Thr Ala Met Leu Arg Ala Lys 
705                 710                 715                 720 


Trp Gly Leu Asn Arg Val Leu Asp Gly Val Met Glu Glu Gln Gly Arg 
                725                 730                 735     


Pro Ala Val Lys Asn Arg Asp Asp His Arg His His Ala Ile Asp Ala 
            740                 745                 750         


Val Val Ile Gly Ala Thr Asp Arg Ala Met Leu Gln Gln Val Ala Thr 
        755                 760                 765             


Leu Ala Ala Arg Ala Arg Glu Gln Asp Ala Glu Arg Leu Ile Gly Asp 
    770                 775                 780                 


Met Pro Thr Pro Trp Pro Asn Phe Leu Glu Asp Val Arg Ala Ala Val 
785                 790                 795                 800 


Ala Arg Cys Val Val Ser His Lys Pro Asp His Gly Pro Glu Gly Gly 
                805                 810                 815     


Leu His Asn Asp Thr Ala Tyr Gly Ile Val Ala Gly Pro Phe Glu Asp 
            820                 825                 830         


Gly Arg Tyr Arg Val Arg His Arg Val Ser Leu Phe Asp Leu Lys Pro 
        835                 840                 845             


Gly Asp Leu Ser Asn Val Arg Cys Asp Ala Pro Leu Gln Ala Glu Leu 
    850                 855                 860                 


Glu Pro Ile Phe Glu Gln Asp Asp Ala Arg Ala Arg Glu Val Ala Leu 
865                 870                 875                 880 


Thr Ala Leu Ala Glu Arg Tyr Arg Gln Arg Lys Val Trp Leu Glu Glu 
                885                 890                 895     


Leu Met Ser Val Leu Pro Ile Arg Pro Arg Gly Glu Asp Gly Lys Thr 
            900                 905                 910         


Leu Pro Asp Ser Ala Pro Tyr Lys Ala Tyr Lys Gly Asp Ser Asn Tyr 
        915                 920                 925             


Cys Tyr Glu Leu Phe Ile Asn Glu Arg Gly Arg Trp Asp Gly Glu Leu 
    930                 935                 940                 


Ile Ser Thr Phe Arg Ala Asn Gln Ala Ala Tyr Arg Arg Phe Arg Asn 
945                 950                 955                 960 


Asp Pro Ala Arg Phe Arg Arg Tyr Thr Ala Gly Gly Arg Pro Leu Leu 
                965                 970                 975     


Met Arg Leu Cys Ile Asn Asp Tyr Ile Ala Val Gly Thr Ala Ala Glu 
            980                 985                 990         


Arg Thr Ile Phe Arg Val Val Lys  Met Ser Glu Asn Lys  Ile Thr Leu 
        995                 1000                 1005             


Ala Glu  His Phe Glu Gly Gly  Thr Leu Lys Gln Arg  Asp Ala Asp 
    1010                 1015                 1020             


Lys Asp  Asp Pro Phe Lys Tyr  Leu Thr Lys Ser Pro  Gly Ala Leu 
    1025                 1030                 1035             


Arg Asp  Leu Gly Ala Arg Arg  Ile Phe Val Asp Leu  Ile Gly Arg 
    1040                 1045                 1050             


Val Leu  Asp Pro Gly Ile Lys  Gly Asp 
    1055                 1060         


<210> 407
<211> 1066
<212> PRT
<213> Rhodopseudomonas palustris

<400> 407
Met Ser Glu Arg Val Val Arg Arg Ile Leu Gly Ile Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Cys Gly Trp Gly Val Val Asp Ile Ser Gly Ala Gly Gly Gly 
            20                  25                  30          


Ile Ile Ala Thr Gly Val Arg Cys Phe Asp Ala Pro Leu Ile Asp Lys 
        35                  40                  45              


Thr Gly Glu Pro Lys Ser Ala Thr Arg Arg Thr Ala Arg Gly Gln Arg 
    50                  55                  60                  


Arg Ile Val Arg Arg Arg Arg Gln Arg Met Asn Gly Val Arg Arg Leu 
65                  70                  75                  80  


Leu Cys Glu Phe Gly Leu Leu Pro Asp Pro Arg Pro Asp Ala Leu Asn 
                85                  90                  95      


Gln Ala Met Arg Arg Ile Ser Thr Ala Ser Ala Ala Ala Gln Val Thr 
            100                 105                 110         


Pro Trp Thr Leu Arg Ala Ala Ala His Gln Arg Leu Leu Ser Asn Glu 
        115                 120                 125             


Glu Leu Ala Val Val Leu Gly His Ile Ala Arg His Arg Gly Phe Arg 
    130                 135                 140                 


Ser Asn Ala Lys Asn Glu Ala Gly Ala Asn Ala Ala Asp Glu Thr Ser 
145                 150                 155                 160 


Lys Met Lys Lys Ala Met Glu Ala Thr Arg Glu Gly Leu Ala Lys Tyr 
                165                 170                 175     


His Ala Phe Gly Asp Met Ile Ala Asn Asp Pro Lys Phe Ala Asn Arg 
            180                 185                 190         


Lys Arg Asn Arg Asp Lys Asp Tyr Ser His Thr Ala Lys Arg Ser Asp 
        195                 200                 205             


Leu Glu Asp Glu Val Arg Ala Ile Leu Arg Ala Gln Leu Arg Phe Gly 
    210                 215                 220                 


Ser Ala Ala Ala Thr Glu Thr Leu Ala Gln Thr Phe Ala Asp Val Ala 
225                 230                 235                 240 


Phe Phe Gln Arg Pro Leu Gln Asp Ser Glu Asp Arg Val Gly Asp Cys 
                245                 250                 255     


Pro Phe Glu Pro Gly Gln Lys Arg Ala Ala Arg Arg Ala Pro Ser Phe 
            260                 265                 270         


Glu Leu Phe Arg Phe Leu Ser Arg Leu Ala Asn Leu Lys Leu Ala Val 
        275                 280                 285             


Gly Arg Ser Pro Glu Arg Arg Leu Thr Ala Glu Glu Ile Ala Leu Ala 
    290                 295                 300                 


Ala Lys Gly Phe Gly Glu Thr Lys Lys Thr Ile Thr Phe Lys Ser Leu 
305                 310                 315                 320 


Arg Glu Ala Leu Asp Leu Asp Pro Asn Ala Arg Phe Ser Gly Ile Gly 
                325                 330                 335     


Lys Asp Lys Glu Ala Ser Leu Asp Val Val Ala Arg Thr Gly Gly Ala 
            340                 345                 350         


Ala Tyr Gly Thr Lys Thr Leu Lys Asp Ala Leu Gly Asp Ala Pro Trp 
        355                 360                 365             


Arg Ser Leu Ser Arg Thr Pro Glu Thr Leu Asp Arg Ile Ala Glu Ile 
    370                 375                 380                 


Leu Ser Phe Arg Glu Asp Ile Thr Ser Ile Arg Asn Gly Leu Glu Asp 
385                 390                 395                 400 


Leu Gly Leu Asp Ser Leu Val Val Glu Ala Leu Met Gln Ala Ala Ala 
                405                 410                 415     


Asn Gly Asp Phe Lys Glu Phe Thr Arg Ala Gly His Ile Ser Ala Arg 
            420                 425                 430         


Ala Ala Arg Asn Ile Ile Pro Gly Leu Arg Glu Gly Leu Val Tyr Ser 
        435                 440                 445             


Glu Ala Cys Ala Arg Val Gly Tyr Asp His Ala Ala Arg Leu Ser Val 
    450                 455                 460                 


Pro Leu Asp Gln Val Gly Ser Pro Val Thr Arg Lys Ala Leu Ser Glu 
465                 470                 475                 480 


Ala Leu Lys Gln Val Arg Ala Val Ala Arg Glu Tyr Gly Pro Ile Asp 
                485                 490                 495     


Tyr Phe His Ile Glu Leu Ala Arg Ser Val Gly Lys Ser Ala Glu Glu 
            500                 505                 510         


Arg Lys Gln Leu Thr Asp Gly Ile Glu Ala Arg Asn Val Glu Lys Ala 
        515                 520                 525             


Lys Arg Arg Lys Gln Ala Glu Glu His Leu Gly Arg Ala Pro Ser Asp 
    530                 535                 540                 


Asp Glu Leu Leu Arg Tyr Glu Leu Ala Lys Glu Gln Asn Phe Lys Cys 
545                 550                 555                 560 


Ile Tyr Ser Gly Asp Ala Ile Asp Pro Ala Gly Val Ala Ala Asn Asp 
                565                 570                 575     


Thr Arg Tyr Gln Val Asp His Ile Leu Pro Trp Ser Arg Phe Gly Asp 
            580                 585                 590         


Asp Ser Tyr Leu Asn Lys Thr Leu Cys Thr Ala Arg Ser Asn Gln Asn 
        595                 600                 605             


Lys Arg Gly Arg Thr Pro Phe Glu Trp Phe Glu Ala Asp Lys Thr Asp 
    610                 615                 620                 


Val Glu Trp Met Glu Tyr Val Ala Arg Val Glu Asn Leu Gln Glu Val 
625                 630                 635                 640 


Lys Gly Arg Lys Lys Arg Asn Tyr Ser Ile Lys Asp Ala Ala Ala Ile 
                645                 650                 655     


Glu Asp Lys Phe Lys Ala Arg Asn Leu Thr Asp Thr Gln Trp Ala Thr 
            660                 665                 670         


Arg Leu Leu Ala Asp Glu Leu Ser Arg Met Phe Pro Pro Arg Glu Cys 
        675                 680                 685             


Glu Arg Ala Ile Cys Gly Arg Ala Asp Gly Gly Asn Asp Gly Leu Thr 
    690                 695                 700                 


Ile Val Glu Glu Arg Arg Val Phe Thr Arg Pro Gly Ala Ile Thr Ser 
705                 710                 715                 720 


Lys Leu Arg Arg Ala Trp Gly Leu Glu Gly Leu Lys Lys Gln Asp Gly 
                725                 730                 735     


Lys Arg Val Glu Asp Asp Arg His His Ala Val Asp Ala Leu Val Leu 
            740                 745                 750         


Ala Ala Thr Thr Glu Ser Leu Leu Gln Arg Leu Thr Val Glu Val Gln 
        755                 760                 765             


Arg Arg Glu Arg Glu Gly Arg Pro Asp Asp Ile Phe His Cys Ala Glu 
    770                 775                 780                 


Pro Trp Arg Gly Phe Arg Ala Asp Val Arg Arg Thr Val Tyr Gly Ser 
785                 790                 795                 800 


Glu Thr Met Pro Gly Ile Phe Val Ser Arg Ala Glu Arg Arg Arg Ala 
                805                 810                 815     


Arg Gly Lys Ala His Asp Ala Thr Ile Lys Gln Ile Arg Glu Ile Glu 
            820                 825                 830         


Gly Glu Arg Leu Val Phe Glu Arg Lys Pro Val Glu Lys Leu Thr Asp 
        835                 840                 845             


Lys Asp Leu Glu Lys Ile Pro Ile Pro Lys Pro Tyr Gly Gln Val Ser 
    850                 855                 860                 


Asp Pro Lys Arg Leu Arg Asp Glu Leu Val Glu Ser Leu Arg Ala Trp 
865                 870                 875                 880 


Ile Ala Ala Gly Lys Pro Lys Asp Arg Pro Pro Leu Ser Pro Lys Gly 
                885                 890                 895     


Asp Val Ile Arg Lys Val Arg Ile Gln Thr Asn Asp Lys Val Ser Val 
            900                 905                 910         


Glu Ile Asn Gly Gly Thr Val Asp Arg Gly Asp Met Ala Arg Val Asp 
        915                 920                 925             


Val Phe Arg Lys Lys Asn Lys Lys Ala Val Trp Glu Tyr Tyr Val Val 
    930                 935                 940                 


Pro Ile Tyr Pro His Gln Ile Val Ala Leu Asn Asp Pro Pro Asp Arg 
945                 950                 955                 960 


Ala Val Ile Ala Tyr Ala Glu Asp Lys Asp Trp Lys Glu Ile Asp Ser 
                965                 970                 975     


Ser Tyr Glu Phe Leu Trp Ser Leu Phe Gly Leu Ser Tyr Val Glu Ile 
            980                 985                 990         


Ser Lys Ala Asn Gly Glu Cys Ile  Asp Gly Tyr Phe Arg  Gly Leu His 
        995                 1000                 1005             


Arg Gly  Thr Gly Ala Ala Ser  Val Cys Lys His Ile  Ser Leu Gly 
    1010                 1015                 1020             


Lys Asp  Ala Thr Val Ser Gly  Ile Gly Leu Lys Thr  Leu Ala Ser 
    1025                 1030                 1035             


Phe Lys  Lys Phe Thr Ile Asp  Arg Leu Gly Arg Lys  Phe Glu Ile 
    1040                 1045                 1050             


Pro Arg  Glu Val Arg Thr Trp  Arg Gly Glu Ala Cys  Thr 
    1055                 1060                 1065     


<210> 408
<211> 1064
<212> PRT
<213> Rhodopseudomonas palustris

<400> 408
Met Ser Glu Cys Val Thr Arg Arg Ile Leu Gly Ile Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Cys Gly Trp Gly Val Ile Glu Val Gly Glu Ala Ser Gly Ser 
            20                  25                  30          


Ile Ile Ala Ser Gly Val Arg Cys Phe Asp Ala Pro Leu Ile Asp Lys 
        35                  40                  45              


Thr Gly Glu Pro Lys Ser Ala Thr Arg Arg Thr Ala Arg Gly Gln Arg 
    50                  55                  60                  


Arg Ile Ile Arg Arg Arg Arg Gln Arg Met Asn Ala Val Arg Arg Leu 
65                  70                  75                  80  


Leu Ala Glu Phe Gly Val Leu Thr Gly Arg Ser Pro Asp Ala Leu His 
                85                  90                  95      


Gln Ala Leu Leu Arg Leu Ser Gln Ser Val Ala Gly Ser Gln Val Thr 
            100                 105                 110         


Pro Trp Thr Leu Arg Ala Ala Ala His Glu Arg Lys Leu Thr Asn Asp 
        115                 120                 125             


Glu Leu Ala Val Val Leu Gly His Ile Ala Arg His Arg Gly Phe Arg 
    130                 135                 140                 


Ser Asn Ser Lys Asn Asp Gly Gly Ala Asn Ala Ala Asp Glu Thr Ser 
145                 150                 155                 160 


Lys Met Lys Lys Ala Met Glu Thr Thr Arg Glu Gly Leu Ala Arg Tyr 
                165                 170                 175     


His Ser Phe Gly Ala Met Ile Ala Ser Asp Pro Lys Phe Ala Asp Arg 
            180                 185                 190         


Lys Arg Asn Arg Asp Lys Asp Tyr Ser His Thr Ala Lys Arg Ser Asp 
        195                 200                 205             


Leu Glu Asp Glu Val Arg Thr Ile Phe Arg Ser Gln Thr Arg Phe Gly 
    210                 215                 220                 


Ser Leu Val Ala Ser Glu Lys Leu Ser Gln Ala Phe Ala Asp Ala Ala 
225                 230                 235                 240 


Phe Phe Gln Arg Pro Leu Gln Asp Ser Glu Asp Met Val Gly Ser Cys 
                245                 250                 255     


Pro Phe Glu Pro Gly Gln Lys Arg Thr Ala Arg Arg Ala Pro Ser Phe 
            260                 265                 270         


Glu Leu Phe Arg Phe Leu Ser Arg Leu Ala Asn Leu Lys Leu Thr Val 
        275                 280                 285             


Gly Arg Ala Pro Glu Arg Arg Leu Thr Pro Asp Glu Ile Ala Leu Ala 
    290                 295                 300                 


Ala Lys Gly Phe Gly Glu Thr Lys Lys Ser Ile Thr Phe Lys Ser Leu 
305                 310                 315                 320 


Arg Glu Ala Leu Asp Leu Asp Pro Asn Ala Arg Phe Ser Gly Val Ala 
                325                 330                 335     


Lys Glu Lys Glu Ser Thr Leu Asp Val Ala Ala Arg Thr Gly Gly Ala 
            340                 345                 350         


Ala Tyr Gly Thr Lys Thr Leu Lys Asp Ala Leu Gly Asp Ala Pro Trp 
        355                 360                 365             


Arg Ser Leu Ser Arg Met Pro Glu Lys Leu Asp Arg Ile Ala Glu Ile 
    370                 375                 380                 


Leu Ser Phe Arg Glu Asp Met Lys Ala Ile Arg Asn Gly Leu Glu Glu 
385                 390                 395                 400 


Val Gly Leu Asp Gly Leu Val Val Asp Ala Leu Met Gln Ala Thr Ala 
                405                 410                 415     


Asn Gly Asp Phe Lys Asp Phe Thr Arg Ala Ala His Ile Ser Ala Leu 
            420                 425                 430         


Ala Ala Arg Asn Ile Ile Pro Gly Leu Arg Glu Gly Leu Val Tyr Ser 
        435                 440                 445             


Asp Ala Cys Thr Arg Val Gly Tyr Asp His Ala Ala Arg Pro Ala Val 
    450                 455                 460                 


Pro Leu Ser Gln Ile Gly Ser Pro Val Thr Arg Lys Ala Leu Ser Glu 
465                 470                 475                 480 


Ala Leu Lys Gln Val Arg Ala Val Ala Arg Glu Tyr Gly Pro Ile Asp 
                485                 490                 495     


Tyr Phe His Ile Glu Leu Ala Arg Ser Ile Gly Lys Ser Ala Glu Glu 
            500                 505                 510         


Arg Lys Lys Leu Thr Asp Gly Ile Glu Ala Arg Asn Val Glu Lys Glu 
        515                 520                 525             


Lys Arg Arg Lys Glu Ala Ala Glu His Leu Gly Arg Ala Pro Ser Asp 
    530                 535                 540                 


Asp Glu Leu Leu Arg Tyr Glu Leu Ala Lys Glu Gln Asn Phe Lys Cys 
545                 550                 555                 560 


Ile Tyr Ser Gly Asp Pro Ile Asp Pro Ala Gly Ile Ser Ala Asn Asp 
                565                 570                 575     


Thr Arg Tyr Gln Val Asp His Ile Leu Pro Trp Ser Arg Phe Gly Asp 
            580                 585                 590         


Asp Ser Tyr Val Asn Lys Thr Leu Cys Thr Ala Arg Ser Asn Gln Asn 
        595                 600                 605             


Lys Arg Gly Arg Thr Pro Phe Glu Trp Phe Asp Ala Asp Lys Thr Glu 
    610                 615                 620                 


Ala Glu Trp Met Glu Tyr Ser Ala Arg Val Glu Asp Leu Lys Glu Val 
625                 630                 635                 640 


Lys Gly Arg Lys Lys Arg Asn Tyr Ser Ile Lys Asp Ala Ala Ser Val 
                645                 650                 655     


Glu Asp Lys Phe Lys Ala Arg Asn Leu Thr Asp Thr Gln Trp Ala Thr 
            660                 665                 670         


Arg Leu Leu Ala Asp Glu Leu Lys Arg Met Phe Pro Pro Arg Glu Cys 
        675                 680                 685             


Glu Arg Val Val Thr Val Arg Ala Asp Gly Gly Asn Asp Gly Leu Ser 
    690                 695                 700                 


Ile Val Glu Glu Arg Arg Val Phe Thr Arg Pro Gly Ala Ile Thr Ser 
705                 710                 715                 720 


Lys Leu Arg Arg Ala Trp Gly Leu Glu Gly Leu Lys Lys Gln Asp Gly 
                725                 730                 735     


Lys Arg Val Glu Asp Asp Arg His His Ala Val Asp Ala Leu Val Leu 
            740                 745                 750         


Ala Ala Thr Thr Glu Ser Leu Leu Asn Arg Leu Thr Val Glu Val Gln 
        755                 760                 765             


Gln Arg Glu Arg Glu Gly Arg Gln Asp Asp Ile Phe His Cys Ser Gln 
    770                 775                 780                 


Pro Trp Pro Gly Phe Arg Val Asp Val Gln Arg Thr Val Tyr Gly Ser 
785                 790                 795                 800 


Glu Thr Met Pro Gly Ile Phe Val Ser Arg Ala Glu Arg Arg Arg Ala 
                805                 810                 815     


Arg Gly Lys Ala His Asp Ala Thr Val Lys Gln Ile Arg Asp Ile Asp 
            820                 825                 830         


Gly Glu Arg Ile Val Phe Glu Arg Lys Pro Ile Glu Lys Leu Thr Asp 
        835                 840                 845             


Lys Asp Leu Glu Arg Ile Pro Val Pro Glu Pro Tyr Gly Lys Ala Ala 
    850                 855                 860                 


Asp Pro Lys Lys Leu Arg Asp Glu Leu Val Glu Asn Leu Arg Ala Trp 
865                 870                 875                 880 


Ile Ala Ala Gly Lys Pro Lys Asp Lys Pro Pro Arg Ser Pro Lys Gly 
                885                 890                 895     


Asp Ile Ile Arg Lys Val Arg Ile Glu Thr Lys Asp Lys Val Ala Val 
            900                 905                 910         


Glu Ile Asn Gly Gly Thr Val Asp Arg Gly Asp Met Ala Arg Val Asp 
        915                 920                 925             


Val Phe Arg Lys Lys Asn Lys Lys Gly Val Trp Glu Phe Tyr Val Ile 
    930                 935                 940                 


Pro Ile Tyr Pro His Gln Ile Val Ala Ser Ala Leu Pro Pro Asn Arg 
945                 950                 955                 960 


Ala Val Ile Ala Tyr Lys Ala Glu Ser Glu Trp Thr Ala Ile Asp Gly 
                965                 970                 975     


Cys Phe Glu Phe Ala Trp Ser Leu Asn Pro Met Ser Tyr Leu Glu Leu 
            980                 985                 990         


Val Lys Ser Asn Gly Glu Leu Ile  Glu Gly Tyr Phe Arg  Ser Met Asp 
        995                 1000                 1005             


Arg Thr  Thr Gly Ala Ile Asn  Leu Ser Pro Met Ser  Thr Asn Ser 
    1010                 1015                 1020             


Glu Thr  Ile Arg Ser Ile Gly  Val Lys Thr Leu Ser  Ser Phe Arg 
    1025                 1030                 1035             


Lys Phe  Thr Val Asp Arg Leu  Gly Arg Lys Phe Glu  Ile Pro Arg 
    1040                 1045                 1050             


Glu Val  Arg Thr Trp Arg Gly  Glu Ala Cys Thr 
    1055                 1060                 


<210> 409
<211> 1173
<212> PRT
<213> Rhodospirillum rubrum


<220>
<223> Rhodospirillum rubrum ATCC 11170

<400> 409
Met Arg Pro Ile Glu Pro Trp Ile Leu Gly Leu Asp Ile Gly Thr Asp 
1               5                   10                  15      


Ser Leu Gly Trp Ala Val Phe Ser Cys Glu Glu Lys Gly Pro Pro Thr 
            20                  25                  30          


Ala Lys Glu Leu Leu Gly Gly Gly Val Arg Leu Phe Asp Ser Gly Arg 
        35                  40                  45              


Asp Ala Lys Asp His Thr Ser Arg Gln Ala Glu Arg Gly Ala Phe Arg 
    50                  55                  60                  


Arg Ala Arg Arg Gln Thr Arg Thr Trp Pro Trp Arg Arg Asp Arg Leu 
65                  70                  75                  80  


Ile Ala Leu Phe Gln Ala Ala Gly Leu Thr Pro Pro Ala Ala Glu Thr 
                85                  90                  95      


Arg Gln Ile Ala Leu Ala Leu Arg Arg Glu Ala Val Ser Arg Pro Leu 
            100                 105                 110         


Ala Pro Asp Ala Leu Trp Ala Ala Leu Leu His Leu Ala His His Arg 
        115                 120                 125             


Gly Phe Arg Ser Asn Arg Ile Asp Lys Arg Glu Arg Ala Ala Ala Lys 
    130                 135                 140                 


Ala Leu Ala Lys Ala Lys Pro Ala Lys Ala Thr Ala Lys Ala Thr Ala 
145                 150                 155                 160 


Pro Ala Lys Glu Ala Asp Asp Glu Ala Gly Phe Trp Glu Gly Ala Glu 
                165                 170                 175     


Ala Ala Leu Arg Gln Arg Met Ala Ala Ser Gly Ala Pro Thr Val Gly 
            180                 185                 190         


Ala Leu Leu Ala Asp Asp Leu Asp Arg Gly Gln Pro Val Arg Met Arg 
        195                 200                 205             


Tyr Asn Gln Ser Asp Arg Asp Gly Val Val Ala Pro Thr Arg Ala Leu 
    210                 215                 220                 


Ile Ala Glu Glu Leu Ala Glu Ile Val Ala Arg Gln Ser Ser Ala Tyr 
225                 230                 235                 240 


Pro Gly Leu Asp Trp Pro Ala Val Thr Arg Leu Val Leu Asp Gln Arg 
                245                 250                 255     


Pro Leu Arg Ser Lys Gly Ala Gly Pro Cys Ala Phe Leu Pro Gly Glu 
            260                 265                 270         


Asp Arg Ala Leu Arg Ala Leu Pro Thr Val Gln Asp Phe Ile Ile Arg 
        275                 280                 285             


Gln Thr Leu Ala Asn Leu Arg Leu Pro Ser Thr Ser Ala Asp Glu Pro 
    290                 295                 300                 


Arg Pro Leu Thr Asp Glu Glu His Ala Lys Ala Leu Ala Leu Leu Ser 
305                 310                 315                 320 


Thr Ala Arg Phe Val Glu Trp Pro Ala Leu Arg Arg Ala Leu Gly Leu 
                325                 330                 335     


Lys Arg Gly Val Lys Phe Thr Ala Glu Thr Glu Arg Asn Gly Ala Lys 
            340                 345                 350         


Gln Ala Ala Arg Gly Thr Ala Gly Asn Leu Thr Glu Ala Ile Leu Ala 
        355                 360                 365             


Pro Leu Ile Pro Gly Trp Ser Gly Trp Asp Leu Asp Arg Lys Asp Arg 
    370                 375                 380                 


Val Phe Ser Asp Leu Trp Ala Ala Arg Gln Asp Arg Ser Ala Leu Leu 
385                 390                 395                 400 


Ala Leu Ile Gly Asp Pro Arg Gly Pro Thr Arg Val Thr Glu Asp Glu 
                405                 410                 415     


Thr Ala Glu Ala Val Ala Asp Ala Ile Gln Ile Val Leu Pro Thr Gly 
            420                 425                 430         


Arg Ala Ser Leu Ser Ala Lys Ala Ala Arg Ala Ile Ala Gln Ala Met 
        435                 440                 445             


Ala Pro Gly Ile Gly Tyr Asp Glu Ala Val Thr Leu Ala Leu Gly Leu 
    450                 455                 460                 


His His Ser His Arg Pro Arg Gln Glu Arg Leu Ala Arg Leu Pro Tyr 
465                 470                 475                 480 


Tyr Ala Ala Ala Leu Pro Asp Val Gly Leu Asp Gly Asp Pro Val Gly 
                485                 490                 495     


Pro Pro Pro Ala Glu Asp Asp Gly Ala Ala Ala Glu Ala Tyr Tyr Gly 
            500                 505                 510         


Arg Ile Gly Asn Ile Ser Val His Ile Ala Leu Asn Glu Thr Arg Lys 
        515                 520                 525             


Ile Val Asn Ala Leu Leu His Arg His Gly Pro Ile Leu Arg Leu Val 
    530                 535                 540                 


Met Val Glu Thr Thr Arg Glu Leu Lys Ala Gly Ala Asp Glu Arg Lys 
545                 550                 555                 560 


Arg Met Ile Ala Glu Gln Ala Glu Arg Glu Arg Glu Asn Ala Glu Ile 
                565                 570                 575     


Asp Val Glu Leu Arg Lys Ser Asp Arg Trp Met Ala Asn Ala Arg Glu 
            580                 585                 590         


Arg Arg Gln Arg Val Arg Leu Ala Arg Arg Gln Asn Asn Leu Cys Pro 
        595                 600                 605             


Tyr Thr Ser Thr Pro Ile Gly His Ala Asp Leu Leu Gly Asp Ala Tyr 
    610                 615                 620                 


Asp Ile Asp His Val Ile Pro Leu Ala Arg Gly Gly Arg Asp Ser Leu 
625                 630                 635                 640 


Asp Asn Met Val Leu Cys Gln Ser Asp Ala Asn Lys Thr Lys Gly Asp 
                645                 650                 655     


Lys Thr Pro Trp Glu Ala Phe His Asp Lys Pro Gly Trp Ile Ala Gln 
            660                 665                 670         


Arg Asp Asp Phe Leu Ala Arg Leu Asp Pro Gln Thr Ala Lys Ala Leu 
        675                 680                 685             


Ala Trp Arg Phe Ala Asp Asp Ala Gly Glu Arg Val Ala Arg Lys Ser 
    690                 695                 700                 


Ala Glu Asp Glu Asp Gln Gly Phe Leu Pro Arg Gln Leu Thr Asp Thr 
705                 710                 715                 720 


Gly Tyr Ile Ala Arg Val Ala Leu Arg Tyr Leu Ser Leu Val Thr Asn 
                725                 730                 735     


Glu Pro Asn Ala Val Val Ala Thr Asn Gly Arg Leu Thr Gly Leu Leu 
            740                 745                 750         


Arg Leu Ala Trp Asp Ile Thr Pro Gly Pro Ala Pro Arg Asp Leu Leu 
        755                 760                 765             


Pro Thr Pro Arg Asp Ala Leu Arg Asp Asp Thr Ala Ala Arg Arg Phe 
    770                 775                 780                 


Leu Asp Gly Leu Thr Pro Pro Pro Leu Ala Lys Ala Val Glu Gly Ala 
785                 790                 795                 800 


Val Gln Ala Arg Leu Ala Ala Leu Gly Arg Ser Arg Val Ala Asp Ala 
                805                 810                 815     


Gly Leu Ala Asp Ala Leu Gly Leu Thr Leu Ala Ser Leu Gly Gly Gly 
            820                 825                 830         


Gly Lys Asn Arg Ala Asp His Arg His His Phe Ile Asp Ala Ala Met 
        835                 840                 845             


Ile Ala Val Thr Thr Arg Gly Leu Ile Asn Gln Ile Asn Gln Ala Ser 
    850                 855                 860                 


Gly Ala Gly Arg Ile Leu Asp Leu Arg Lys Trp Pro Arg Thr Asn Phe 
865                 870                 875                 880 


Glu Pro Pro Tyr Pro Thr Phe Arg Ala Glu Val Met Lys Gln Trp Asp 
                885                 890                 895     


His Ile His Pro Ser Ile Arg Pro Ala His Arg Asp Gly Gly Ser Leu 
            900                 905                 910         


His Ala Ala Thr Val Phe Gly Val Arg Asn Arg Pro Asp Ala Arg Val 
        915                 920                 925             


Leu Val Gln Arg Lys Pro Val Glu Lys Leu Phe Leu Asp Ala Asn Ala 
    930                 935                 940                 


Lys Pro Leu Pro Ala Asp Lys Ile Ala Glu Ile Ile Asp Gly Phe Ala 
945                 950                 955                 960 


Ser Pro Arg Met Ala Lys Arg Phe Lys Ala Leu Leu Ala Arg Tyr Gln 
                965                 970                 975     


Ala Ala His Pro Glu Val Pro Pro Ala Leu Ala Ala Leu Ala Val Ala 
            980                 985                 990         


Arg Asp Pro Ala Phe Gly Pro Arg  Gly Met Thr Ala Asn  Thr Val Ile 
        995                 1000                 1005             


Ala Gly  Arg Ser Asp Gly Asp  Gly Glu Asp Ala Gly  Leu Ile Thr 
    1010                 1015                 1020             


Pro Phe  Arg Ala Asn Pro Lys  Ala Ala Val Arg Thr  Met Gly Asn 
    1025                 1030                 1035             


Ala Val  Tyr Glu Val Trp Glu  Ile Gln Val Lys Gly  Arg Pro Arg 
    1040                 1045                 1050             


Trp Thr  His Arg Val Leu Thr  Arg Phe Asp Arg Thr  Gln Pro Ala 
    1055                 1060                 1065             


Pro Pro  Pro Pro Pro Glu Asn  Ala Arg Leu Val Met  Arg Leu Arg 
    1070                 1075                 1080             


Arg Gly  Asp Leu Val Tyr Trp  Pro Leu Glu Ser Gly  Asp Arg Leu 
    1085                 1090                 1095             


Phe Leu  Val Lys Lys Met Ala  Val Asp Gly Arg Leu  Ala Leu Trp 
    1100                 1105                 1110             


Pro Ala  Arg Leu Ala Thr Gly  Lys Ala Thr Ala Leu  Tyr Ala Gln 
    1115                 1120                 1125             


Leu Ser  Cys Pro Asn Ile Asn  Leu Asn Gly Asp Gln  Gly Tyr Cys 
    1130                 1135                 1140             


Val Gln  Ser Ala Glu Gly Ile  Arg Lys Glu Lys Ile  Arg Thr Thr 
    1145                 1150                 1155             


Ser Cys  Thr Ala Leu Gly Arg  Leu Arg Leu Ser Lys  Lys Ala Thr 
    1160                 1165                 1170             


<210> 410
<211> 1059
<212> PRT
<213> Rhodovulum sp.


<220>
<223> Rhodovulum sp. PH10

<400> 410
Met Gly Ile Arg Phe Ala Phe Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Trp Arg Thr Gly Pro Gly Val Phe Gly Glu Asp Thr Ala Ala 
            20                  25                  30          


Ser Leu Asp Gly Ser Gly Val Leu Ile Phe Lys Asp Gly Arg Asn Pro 
        35                  40                  45              


Lys Asp Gly Gln Ser Leu Ala Thr Met Arg Arg Val Pro Arg Gln Ser 
    50                  55                  60                  


Arg Lys Arg Arg Asp Arg Phe Val Leu Arg Arg Arg Asp Leu Leu Ala 
65                  70                  75                  80  


Ala Leu Arg Lys Ala Gly Leu Phe Pro Val Asp Val Glu Glu Gly Arg 
                85                  90                  95      


Arg Leu Ala Ala Thr Asp Pro Tyr His Leu Arg Ala Lys Ala Leu Asp 
            100                 105                 110         


Glu Ser Leu Thr Pro His Glu Met Gly Arg Val Ile Phe His Leu Asn 
        115                 120                 125             


Gln Arg Arg Gly Phe Arg Ser Asn Arg Lys Ala Asp Arg Gln Asp Arg 
    130                 135                 140                 


Glu Lys Gly Lys Ile Ala Glu Gly Ser Lys Arg Leu Ala Glu Thr Leu 
145                 150                 155                 160 


Ala Ala Thr Asn Cys Arg Thr Leu Gly Glu Phe Leu Trp Ser Arg His 
                165                 170                 175     


Arg Gly Thr Pro Arg Thr Arg Ser Pro Thr Arg Ile Arg Met Glu Gly 
            180                 185                 190         


Glu Gly Ala Lys Ala Leu Tyr Ala Phe Tyr Pro Thr Arg Glu Met Val 
        195                 200                 205             


Arg Ala Glu Phe Glu Arg Leu Trp Thr Ala Gln Ser Arg Phe Ala Pro 
    210                 215                 220                 


Asp Leu Leu Thr Pro Glu Arg His Glu Glu Ile Ala Gly Ile Leu Phe 
225                 230                 235                 240 


Arg Gln Arg Asp Leu Ala Pro Pro Lys Ile Gly Cys Cys Thr Phe Glu 
                245                 250                 255     


Pro Ser Glu Arg Arg Leu Pro Arg Ala Leu Pro Ser Val Glu Ala Arg 
            260                 265                 270         


Gly Ile Tyr Glu Arg Leu Ala His Leu Arg Ile Thr Thr Gly Pro Val 
        275                 280                 285             


Ser Asp Arg Gly Leu Thr Arg Pro Glu Arg Asp Val Leu Ala Ser Ala 
    290                 295                 300                 


Leu Leu Ala Gly Lys Ser Leu Thr Phe Lys Ala Val Arg Lys Thr Leu 
305                 310                 315                 320 


Lys Ile Leu Pro His Ala Leu Val Asn Phe Glu Glu Ala Gly Glu Lys 
                325                 330                 335     


Gly Leu Asp Gly Ala Leu Thr Ala Lys Leu Leu Ser Lys Pro Asp His 
            340                 345                 350         


Tyr Gly Ala Ala Trp His Gly Leu Ser Phe Ala Glu Lys Asp Thr Phe 
        355                 360                 365             


Val Gly Lys Leu Leu Asp Glu Ala Asp Glu Glu Arg Leu Ile Arg Arg 
    370                 375                 380                 


Leu Val Thr Glu Asn Arg Leu Ser Glu Asp Ala Ala Arg Arg Cys Ala 
385                 390                 395                 400 


Ser Ile Pro Leu Ala Asp Gly Tyr Gly Arg Leu Gly Arg Thr Ala Asn 
                405                 410                 415     


Thr Glu Ile Leu Ala Ala Leu Val Glu Glu Thr Asp Glu Thr Gly Thr 
            420                 425                 430         


Val Val Thr Tyr Ala Glu Ala Val Arg Arg Ala Gly Glu Arg Thr Gly 
        435                 440                 445             


Arg Asn Trp His His Ser Asp Glu Arg Asp Gly Val Ile Leu Asp Arg 
    450                 455                 460                 


Leu Pro Tyr Tyr Gly Glu Ile Leu Gln Arg His Val Val Pro Gly Ser 
465                 470                 475                 480 


Gly Glu Pro Glu Glu Lys Asn Glu Ala Ala Arg Trp Gly Arg Leu Ala 
                485                 490                 495     


Asn Pro Thr Val His Ile Gly Leu Asn Gln Leu Arg Lys Val Val Asn 
            500                 505                 510         


Arg Leu Ile Ala Ala His Gly Arg Pro Asp Gln Ile Val Val Glu Leu 
        515                 520                 525             


Ala Arg Glu Leu Lys Leu Asn Arg Glu Gln Lys Glu Arg Leu Asp Arg 
    530                 535                 540                 


Glu Asn Arg Lys Asn Arg Glu Glu Asn Glu Arg Arg Thr Ala Ile Leu 
545                 550                 555                 560 


Ala Glu His Gly Gln Arg Asp Thr Ala Glu Asn Lys Ile Arg Leu Arg 
                565                 570                 575     


Leu Phe Glu Glu Gln Ala Arg Ala Asn Ala Gly Ile Ala Leu Cys Pro 
            580                 585                 590         


Tyr Thr Gly Arg Ala Ile Gly Ile Ala Glu Leu Phe Thr Ser Glu Val 
        595                 600                 605             


Glu Ile Asp His Ile Leu Pro Val Ser Leu Thr Leu Asp Asp Ser Leu 
    610                 615                 620                 


Ala Asn Arg Val Leu Cys Arg Arg Glu Ala Asn Arg Glu Lys Arg Arg 
625                 630                 635                 640 


Gln Thr Pro Phe Gln Ala Phe Gly Ala Thr Pro Ala Trp Asn Asp Ile 
                645                 650                 655     


Val Ala Arg Ala Ala Lys Leu Pro Pro Asn Lys Arg Trp Arg Phe Asp 
            660                 665                 670         


Pro Ala Ala Leu Glu Arg Phe Glu Arg Glu Gly Gly Phe Leu Gly Arg 
        675                 680                 685             


Gln Leu Asn Glu Thr Lys Tyr Leu Ser Arg Leu Ala Lys Ile Tyr Leu 
    690                 695                 700                 


Gly Lys Ile Cys Asp Pro Asp Arg Val Tyr Val Thr Pro Gly Thr Leu 
705                 710                 715                 720 


Thr Gly Leu Leu Arg Ala Arg Trp Gly Leu Asn Ser Ile Leu Ser Asp 
                725                 730                 735     


Ser Asn Phe Lys Asn Arg Ser Asp His Arg His His Ala Val Asp Ala 
            740                 745                 750         


Val Val Ile Gly Val Leu Thr Arg Gly Met Ile Gln Arg Ile Ala His 
        755                 760                 765             


Asp Ala Ala Arg Ala Glu Asp Gln Asp Leu Asp Arg Val Phe Arg Asp 
    770                 775                 780                 


Val Pro Val Pro Phe Glu Asp Phe Arg Asp His Val Arg Glu Arg Val 
785                 790                 795                 800 


Ser Thr Ile Thr Val Ala Val Lys Pro Glu His Gly Lys Gly Gly Ala 
                805                 810                 815     


Leu His Glu Asp Thr Ser Tyr Gly Leu Val Pro Asp Thr Asp Pro Asn 
            820                 825                 830         


Ala Ala Leu Gly Asn Leu Val Val Arg Lys Pro Ile Arg Ser Leu Thr 
        835                 840                 845             


Ala Gly Glu Val Asp Arg Val Arg Asp Arg Ala Leu Arg Ala Arg Leu 
    850                 855                 860                 


Gly Ala Leu Ala Ala Pro Phe Arg Asp Glu Ser Gly Arg Val Arg Asp 
865                 870                 875                 880 


Ala Lys Gly Leu Ala Gln Ala Leu Glu Ala Phe Gly Ala Glu Asn Gly 
                885                 890                 895     


Ile Arg Arg Val Arg Ile Leu Lys Pro Asp Ala Ser Val Val Thr Ile 
            900                 905                 910         


Ala Asp Arg Arg Thr Gly Val Pro Tyr Arg Ala Val Ala Pro Gly Glu 
        915                 920                 925             


Asn His His Val Asp Ile Val Gln Met Arg Asp Gly Ser Trp Arg Gly 
    930                 935                 940                 


Phe Ala Ala Ser Val Phe Glu Val Asn Arg Pro Gly Trp Arg Pro Glu 
945                 950                 955                 960 


Trp Glu Val Lys Lys Leu Gly Gly Lys Leu Val Met Arg Leu His Lys 
                965                 970                 975     


Gly Asp Met Val Glu Leu Ser Asp Lys Asp Gly Gln Arg Arg Val Lys 
            980                 985                 990         


Val Val Gln Gln Ile Glu Ile Ser  Ala Asn Arg Val Arg  Leu Ser Pro 
        995                 1000                 1005             


His Asn  Asp Gly Gly Lys Leu  Gln Asp Arg His Ala  Asp Ala Asp 
    1010                 1015                 1020             


Asp Pro  Phe Arg Trp Asp Leu  Ala Thr Ile Pro Leu  Leu Lys Asp 
    1025                 1030                 1035             


Arg Gly  Cys Val Ala Val Arg  Val Asp Pro Ile Gly  Val Val Thr 
    1040                 1045                 1050             


Leu Arg  Arg Ser Asn Val 
    1055                 


<210> 411
<211> 1405
<212> PRT
<213> Riemerella anatipestifer

<400> 411
Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Lys Glu Ala Glu Asn Ser Asn Glu Lys Ser Glu Ile Ile 
            20                  25                  30          


Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Lys Thr Asn 
        35                  40                  45              


Phe Glu Ala Gly Arg Pro Leu Ser Thr Asn Ala Asp Arg Thr Ala Lys 
    50                  55                  60                  


Arg Ser Ala Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Lys Asn 
65                  70                  75                  80  


Leu Ile Asp Leu Leu Ile Lys Asn Gln Leu Ile Asp Lys Asp Thr Pro 
                85                  90                  95      


Leu Thr Glu Ile Gly Lys Asn Thr Thr His Gln Thr Leu Glu Leu Arg 
            100                 105                 110         


Ala Lys Ala Ala Arg Glu Arg Ile Glu Leu Glu Asp Leu Ala Arg Val 
        115                 120                 125             


Phe Leu Ala Ile Asn Lys Lys Arg Gly Tyr Arg Ser Ser Arg Lys Val 
    130                 135                 140                 


Asn Asn Glu Glu Glu Gly Gln Ala Val Asp Gly Met Ala Val Ala Lys 
145                 150                 155                 160 


Lys Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gln Tyr Ala Tyr Glu Leu 
                165                 170                 175     


Leu Ser Lys Gly Lys Lys Tyr Val Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Ala Glu Phe Asn Ala Ile Trp Glu Tyr Gln Lys Gln Phe Tyr Ala 
        195                 200                 205             


Asp Ile Leu Asp Asp Glu Leu Tyr Asn Ala Leu Lys Gly Gln Gly Gln 
    210                 215                 220                 


Gln Asn Ser Arg Lys Arg Phe Leu Ala Ile Lys Gly Val Tyr Thr Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Lys Arg Asp Asp Val Lys Leu Arg His Tyr Lys Trp 
                245                 250                 255     


Arg Ser Glu Ala Ile Ser Lys Lys Ile Asn Ile Glu Glu Val Ala Tyr 
            260                 265                 270         


Val Leu Val Glu Ile Asn Asn Asp Leu Asn Lys Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Lys Glu Thr 
    290                 295                 300                 


Val Gly Glu Asn Leu Trp Lys Gln Ile Gln Lys Asn Pro His Thr Ser 
305                 310                 315                 320 


Leu Lys Asn Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Gln Ile Trp Glu Thr Gln Ala Gln Phe His Pro Gln Leu Thr Leu Ala 
            340                 345                 350         


Leu Lys Glu Gln Ile Arg Asp Val Ile Ile Phe Tyr Gln Arg Lys Leu 
        355                 360                 365             


Lys Ser Gln Lys Gly Leu Leu Ser Phe Cys Gln Phe Glu Ser Trp Glu 
    370                 375                 380                 


Ile Glu Arg Lys Asp Glu Asn Gly Asn Val Ile Leu Asn Lys Thr Thr 
385                 390                 395                 400 


Gln Leu Pro Lys Arg Gln Thr Val Gly Arg Arg Val Ala Pro Lys Ser 
                405                 410                 415     


Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln Asn Ile Asn Asn Leu 
            420                 425                 430         


Glu Val Thr Lys Ile Ser Glu Gly Ala Ser Lys Asn Lys Lys Glu Thr 
        435                 440                 445             


Glu Thr Leu Ser Asp Asp Glu Arg Lys Leu Leu Phe Glu Glu Leu Asn 
    450                 455                 460                 


Leu Arg Gly Asn Leu Ser Gln Lys Glu Val Leu Gln Ile Leu Gly Leu 
465                 470                 475                 480 


Lys Asp Lys Glu Tyr Lys Thr Asn Phe Ser Glu Gly Leu Glu Gly Asn 
                485                 490                 495     


Arg Thr Asn Ala Ala Leu Phe Asn Ile Tyr Gln Gln Ile Ala Glu Asn 
            500                 505                 510         


Glu Gly Tyr Gly Phe Asp Trp Ser Lys Lys Ser Ala Gln Glu Ile Lys 
        515                 520                 525             


Glu Glu Leu Lys Ala Val Phe Pro Gln Ile Gly Ile Gln Ala Asp Ile 
    530                 535                 540                 


Leu Asp Phe Asn Ala Asn Leu Asp Gly Lys Glu Phe Glu Asn Gln Ala 
545                 550                 555                 560 


Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser Ala Glu Glu Asp Asp Lys 
                565                 570                 575     


Ile Asn Glu Glu Asp Gln Ile Ile Tyr Gly Asn Ser Ala Val Ser Leu 
            580                 585                 590         


Lys Lys Lys Leu Cys Glu Lys Phe Gly Phe Thr Pro Glu Tyr Ala Lys 
        595                 600                 605             


Trp Ile Ala Asn Val Ser Leu Gln Asp Asp Tyr Gly Asn Leu Ser Thr 
    610                 615                 620                 


Lys Ala Met Arg Lys Ile Ile Pro Tyr Leu Ile Asp Gly Asn Asp Tyr 
625                 630                 635                 640 


Ser Glu Ala Cys Ala Leu Ala Gly Tyr Asn His Ser Asn Ser Leu Thr 
                645                 650                 655     


Lys Glu Glu Asn Asp Asn Arg Glu Leu Leu Asp Lys Leu Glu Leu Leu 
            660                 665                 670         


Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Leu Asn Gln 
        675                 680                 685             


Met Val Asn Val Val Asn Gln Val Ile Glu Thr Tyr Gly Lys Pro Asp 
    690                 695                 700                 


Glu Val Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Ser Ala Glu Lys 
705                 710                 715                 720 


Arg Ala Glu Met Thr Lys Ser Ile Asn Glu Ala Thr Arg Arg Asn Glu 
                725                 730                 735     


Asp Ile Lys Lys Leu Ile Thr Lys Asp Phe Gly Ile Pro Asn Pro Thr 
            740                 745                 750         


Lys Ser Asp Val Val Arg Tyr Arg Leu Trp Glu Glu Leu Ala Pro Leu 
        755                 760                 765             


Ala Tyr Lys Asp Val Phe Thr Gly Lys Gln Ile Lys Lys Glu Asp Leu 
    770                 775                 780                 


Phe Ser Ser Lys Ile Asp Ile Glu His Ile Ile Pro Lys Ala Leu Leu 
785                 790                 795                 800 


Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Val Phe Arg Glu Thr Asn 
                805                 810                 815     


Leu Lys Lys Ala Asp Arg Thr Ala Tyr Asp Phe Ile Glu Ser Asp Tyr 
            820                 825                 830         


Asn Ala Thr Leu Asp Asp Tyr Ile Gln Arg Val Glu Thr Leu Tyr Asn 
        835                 840                 845             


Asn Thr Lys Gly Thr Ile Ser Lys Gly Lys Arg Asn Lys Leu Leu Met 
    850                 855                 860                 


Ala Gln Lys Asn Leu Pro Asp Gly Phe Ile Glu Arg Asp Leu Arg Asn 
865                 870                 875                 880 


Ser Gln Tyr Ile Ala Lys Lys Ala Lys Ala Met Leu Tyr Gln Val Phe 
                885                 890                 895     


Lys Asp Val Asn Val Thr Ser Gly Ser Ile Thr Asp Arg Leu Arg Glu 
            900                 905                 910         


Asp Trp Asp Leu Ile Asn Val Met Lys Glu Leu Asn Phe Pro Lys Tyr 
        915                 920                 925             


Lys Ala Leu Gly Leu Thr Glu Ile Glu Glu Arg Tyr Asp Ile Gly Gln 
    930                 935                 940                 


Glu Lys Thr Lys Arg Val Glu Val Ile Thr Asp Trp Thr Lys Arg Asn 
945                 950                 955                 960 


Asp His Arg His His Ala Met Asn Ala Leu Thr Val Ala Phe Thr Thr 
                965                 970                 975     


Ser Ser His Ile Gln Tyr Leu Asn Tyr Leu Asn Ala Arg Lys Asn Glu 
            980                 985                 990         


Ser His Lys Glu His Lys Asn Ile  Lys Gly Ile Glu Asn  Lys Ile Thr 
        995                 1000                 1005             


His Lys  Gln Lys Asp Lys Arg  Lys Phe Ile Pro Pro  Met Pro Asn 
    1010                 1015                 1020             


Phe Arg  Glu Glu Ala Lys Lys  His Ile Glu Thr Ile  Leu Val Ser 
    1025                 1030                 1035             


Ile Lys  Asn Lys Asn Lys Val  Tyr Thr Lys Asn Ile  Asn Lys Thr 
    1040                 1045                 1050             


Lys Lys  Lys Ser Gly His Asn  Thr Lys Glu Gln Leu  Thr Pro Arg 
    1055                 1060                 1065             


Gly Gln  Leu His Lys Glu Thr  Val Tyr Gly Lys Ser  Lys Arg Pro 
    1070                 1075                 1080             


Met Ser  Lys Pro Thr Lys Ile  Asn Lys Asn Phe Ser  Leu Glu Gln 
    1085                 1090                 1095             


Ala Gln  Leu Ile Ile Asn Val  Gln Glu Lys Glu Leu  Val Leu Arg 
    1100                 1105                 1110             


His Leu  Ala Gln Phe Asp Asn  Asn Pro Ala Val Ala  Phe Asp Thr 
    1115                 1120                 1125             


Lys Thr  Leu Lys Lys Met Pro  Leu Leu Lys Asn Gly  Glu Pro Leu 
    1130                 1135                 1140             


Lys Glu  Val Leu Cys Phe Glu  Glu Ile Phe Thr Ile  Arg Lys Asp 
    1145                 1150                 1155             


Ile Thr  Pro Asp Leu Lys Ile  Glu Lys Val Val Asp  Glu Lys Ile 
    1160                 1165                 1170             


Lys Ala  Ile Leu Glu Gln Arg  Lys Lys Asp Phe Gly  Gly Asn Ala 
    1175                 1180                 1185             


Lys Glu  Ala Phe Ser Asp Leu  Asp Lys Asn Pro Ile  Trp Leu Asn 
    1190                 1195                 1200             


Lys Lys  Lys Gly Ile Cys Ile  Lys Arg Val Thr Ile  Thr Gly Val 
    1205                 1210                 1215             


Ser Asn  Ala Glu Ala Leu His  His Gln Lys Asp His  Leu Gly Arg 
    1220                 1225                 1230             


Glu Ile  Leu Asp Asp Asn Gly  Asn Pro Ile Pro Ala  Asp Phe Val 
    1235                 1240                 1245             


Ser Thr  Gly Asn Asn His His  Leu Ala Val Tyr Leu  Asp Ser Glu 
    1250                 1255                 1260             


Gly Lys  Leu Gln Asp Asn Ile  Val Ser Phe Tyr Glu  Ala Val Val 
    1265                 1270                 1275             


Arg Thr  Ser Gln Gly Leu Pro  Val Val Asp Lys Gly  Leu Asn Lys 
    1280                 1285                 1290             


Asp Leu  Gly Trp Lys Phe Leu  Phe Ser Leu Lys Gln  Asn Glu Met 
    1295                 1300                 1305             


Phe Val  Phe Pro Asn Asp Asp  Phe Asp Ile Asn Asp  Phe Asp Leu 
    1310                 1315                 1320             


Leu Asp  Asp Lys Lys Ala Glu  Leu Ile Ser Lys His  Leu Tyr Arg 
    1325                 1330                 1335             


Val Gln  Lys Ile Ser Lys Val  Ser Ala Gly Asn Ser  Phe Val Arg 
    1340                 1345                 1350             


Asp Ile  Val Phe Arg His His  Leu Glu Thr Thr Val  Lys Glu Val 
    1355                 1360                 1365             


Lys Glu  Leu Lys Asp Ile Ser  Tyr Ile Gln Leu Lys  Ser Leu Glu 
    1370                 1375                 1380             


Gly Leu  Arg Asn Ile Lys Lys  Val Arg Ile Asn His  Ile Gly Lys 
    1385                 1390                 1395             


Ile Val  Gln Val Gly Glu Tyr  
    1400                 1405 


<210> 412
<211> 1400
<212> PRT
<213> Riemerella anatipestifer

<400> 412
Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Lys Glu Thr Glu Asn Ser Asn Glu Lys Ser Glu Ile Ile 
            20                  25                  30          


Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Lys Thr Asn 
        35                  40                  45              


Phe Glu Ala Gly Arg Pro Leu Ser Thr Asn Ala Asp Arg Thr Ala Lys 
    50                  55                  60                  


Arg Ser Ala Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Lys Asn 
65                  70                  75                  80  


Leu Ile Asp Leu Leu Ile Lys His Arg Leu Ile Asp Lys Asp Thr Pro 
                85                  90                  95      


Leu Thr Glu Ile Gly Lys Asn Thr Thr His Gln Thr Leu Glu Leu Arg 
            100                 105                 110         


Ala Lys Ala Ala Arg Glu Arg Ile Glu Leu Glu Asp Leu Ala Arg Val 
        115                 120                 125             


Phe Leu Ala Ile Asn Lys Lys Arg Gly Tyr Arg Ser Ser Arg Lys Val 
    130                 135                 140                 


Asn Asn Glu Glu Glu Gly Gln Val Val Asp Gly Met Ala Val Ala Lys 
145                 150                 155                 160 


Lys Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gln Tyr Ala Tyr Glu Leu 
                165                 170                 175     


Leu Ser Lys Gly Lys Lys Tyr Val Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Ala Glu Phe Asp Ser Ile Trp Glu Tyr Gln Lys Gln Phe Tyr Ala 
        195                 200                 205             


Asp Ile Leu Asp Asp Glu Leu Tyr Asn Ala Leu Lys Gly Gln Gly Gln 
    210                 215                 220                 


Gln Asn Ser Arg Lys Arg Phe Leu Ala Ile Lys Gly Val Tyr Thr Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Lys Arg Asp Glu Val Lys Leu Gln His Tyr Lys Trp 
                245                 250                 255     


Arg Ser Glu Ala Ile Thr Gln Lys Leu Ser Ile Glu Glu Val Ala Tyr 
            260                 265                 270         


Val Leu Val Glu Ile Asn Asn Asp Leu Asn Lys Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Lys Glu Thr 
    290                 295                 300                 


Val Gly Glu Asn Leu Trp Lys Gln Ile Gln Lys Asn Pro His Thr Ser 
305                 310                 315                 320 


Leu Lys Asn Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Gln Ile Trp Glu Thr Gln Ala Gln Phe His Pro Gln Leu Thr Leu Ala 
            340                 345                 350         


Leu Lys Glu Gln Ile Arg Asp Val Val Ile Phe Tyr Gln Arg Lys Leu 
        355                 360                 365             


Lys Ser Gln Lys Gly Leu Leu Ser Phe Cys Gln Phe Glu Ser Trp Glu 
    370                 375                 380                 


Ile Glu Arg Lys Asp Glu Asn Gly Asn Val Ile Leu Asn Lys Thr Thr 
385                 390                 395                 400 


Gln Leu Pro Lys Arg Gln Thr Val Gly Arg Arg Val Ala Pro Lys Ser 
                405                 410                 415     


Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln Asn Ile Asn Asn Leu 
            420                 425                 430         


Glu Ile Ala Lys Ile Ser Asp Gly Asn Ser Lys Asn Lys Lys Glu Thr 
        435                 440                 445             


Glu Ala Leu Ser Asp Asp Glu Arg Lys Leu Leu Phe Glu Glu Leu Asn 
    450                 455                 460                 


Leu Arg Gly Asn Leu Ser Gln Lys Glu Val Leu Gln Ile Leu Gly Leu 
465                 470                 475                 480 


Lys Asp Lys Glu Tyr Lys Thr Asn Phe Pro Glu Gly Leu Glu Gly Asn 
                485                 490                 495     


Arg Thr Asn Ala Ala Leu Phe Asn Ile Tyr Gln Gln Ile Ala Glu Asn 
            500                 505                 510         


Glu Gly Tyr Gly Asp Trp Thr Lys Lys Ser Ala Gln Glu Ile Lys Glu 
        515                 520                 525             


Glu Leu Lys Ala Val Phe Pro Gln Ile Gly Ile Gln Ala Asp Ile Leu 
    530                 535                 540                 


Asp Phe Asn Ala Glu Leu Asp Gly Lys Glu Phe Glu Asn Gln Ala Ser 
545                 550                 555                 560 


Tyr Gln Leu Trp His Leu Leu Tyr Ser Ala Glu Glu Asp Asp Lys Ile 
                565                 570                 575     


Asn Glu Glu Asp Gln Ile Ile Tyr Gly Asn Ser Ala Val Ser Leu Lys 
            580                 585                 590         


Lys Lys Leu Cys Glu Lys Phe Gly Phe Thr Pro Glu Tyr Ala Lys Trp 
        595                 600                 605             


Ile Ala Asn Val Ser Leu Gln Asp Asp Tyr Gly Asn Leu Ser Thr Lys 
    610                 615                 620                 


Ala Met Arg Lys Ile Ile Pro Tyr Leu Ile Asp Gly Asn Asp Tyr Ser 
625                 630                 635                 640 


Glu Ala Cys Ala Leu Ala Gly Tyr Asn His Ser Asn Ser Leu Thr Lys 
                645                 650                 655     


Glu Glu Asn Asp Asn Arg Glu Arg Leu Asn Lys Leu Glu Leu Leu Pro 
            660                 665                 670         


Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Leu Asn Gln Met 
        675                 680                 685             


Val Asn Val Val Asn Gln Val Ile Glu Thr Tyr Gly Lys Pro Asp Glu 
    690                 695                 700                 


Val Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Ser Ala Glu Glu Arg 
705                 710                 715                 720 


Ala Glu Met Thr Lys Gly Ile Asn Glu Ala Thr Arg Arg Asn Glu Asp 
                725                 730                 735     


Ile Lys Lys Leu Ile Thr Lys Asn Phe Gly Ile Pro Asn Pro Thr Lys 
            740                 745                 750         


Asn Asp Val Val Arg Tyr Arg Leu Trp Glu Glu Leu Ala Pro Leu Ala 
        755                 760                 765             


Tyr Lys Asp Val Phe Thr Gly Arg Gln Ile Lys Lys Glu Asp Leu Phe 
    770                 775                 780                 


Ser Ser Lys Ile Asp Ile Glu His Ile Ile Pro Lys Ala Leu Leu Phe 
785                 790                 795                 800 


Asp Asp Ser Phe Ser Asn Lys Thr Leu Ala Phe Arg Glu Thr Asn Leu 
                805                 810                 815     


Lys Lys Ala Asp Arg Thr Ala Tyr Gly Phe Ile Glu Ser Asp Tyr Asn 
            820                 825                 830         


Ala Thr Leu Asp Asp Tyr Ile Gln Arg Val Glu Thr Leu Tyr Asn Asn 
        835                 840                 845             


Ala Lys Gly Thr Ile Ser Lys Gly Lys Arg Asn Lys Leu Leu Met Ala 
    850                 855                 860                 


Gln Lys Asn Leu Pro Asp Gly Phe Ile Glu Arg Asp Leu Arg Asn Ser 
865                 870                 875                 880 


Gln Tyr Ile Ala Lys Lys Ala Lys Ser Met Ile Glu Lys Val Phe Asn 
                885                 890                 895     


Asp Val Asn Val Thr Ser Gly Ser Ile Thr Asp Arg Leu Arg Glu Asp 
            900                 905                 910         


Trp Asp Leu Ile Asn Val Met Lys Glu Leu Asn Phe Pro Lys Tyr Lys 
        915                 920                 925             


Ala Leu Gly Leu Thr Glu Ile Glu Glu Arg Tyr Asp Ile Gly Gln Glu 
    930                 935                 940                 


Lys Thr Lys Lys Val Glu Val Ile Thr Asp Trp Thr Lys Arg Asn Asp 
945                 950                 955                 960 


His Arg His His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Thr Lys 
                965                 970                 975     


Ser His Val Gln Tyr Leu Asn Asn Leu Asn Thr Ile His Ser Leu Lys 
            980                 985                 990         


Gly Asp Glu Val Asp Leu Glu Leu  Ser Lys Leu Tyr Gly  Leu Lys Asn 
        995                 1000                 1005             


Thr Ile  Thr Glu Val Val Asn  Lys Lys Arg Lys Phe  Ile Pro Pro 
    1010                 1015                 1020             


Met Pro  Asn Phe Arg Glu Glu  Ala Lys Lys His Ile  Glu Thr Ile 
    1025                 1030                 1035             


Leu Val  Ser Ile Lys Asn Lys  Asn Lys Val Tyr Thr  Lys Asn Ile 
    1040                 1045                 1050             


Asn Lys  Thr Lys Lys Glu Ser  Gly Tyr His Thr Lys  Glu Gln Leu 
    1055                 1060                 1065             


Thr Pro  Arg Gly Gln Leu His  Lys Glu Thr Val Tyr  Gly Lys Ser 
    1070                 1075                 1080             


Lys Arg  Pro Met Asn Lys Pro  Thr Lys Ile Asn Lys  Asn Phe Ser 
    1085                 1090                 1095             


Leu Glu  Gln Ala Gln Leu Ile  Ile Asn Val Gln Glu  Lys Glu Leu 
    1100                 1105                 1110             


Val Leu  Arg His Leu Ala Gln  Phe Asp Asn Asn Pro  Ala Val Ala 
    1115                 1120                 1125             


Phe Asp  Thr Lys Thr Leu Lys  Lys Met Pro Leu Leu  Lys Asn Gly 
    1130                 1135                 1140             


Glu Pro  Leu Lys Glu Val Leu  Cys Phe Glu Glu Ile  Phe Thr Ile 
    1145                 1150                 1155             


Arg Lys  Asp Ile Thr Pro Asp  Leu Lys Ile Glu Lys  Val Val Asp 
    1160                 1165                 1170             


Glu Lys  Ile Lys Ala Ile Leu  Glu Gln Arg Lys Lys  Asp Phe Gly 
    1175                 1180                 1185             


Gly Asn  Ala Lys Glu Ala Phe  Ser Asp Leu Asp Lys  Asn Pro Ile 
    1190                 1195                 1200             


Trp Leu  Asn Lys Glu Lys Gly  Ile Cys Ile Lys Arg  Val Thr Ile 
    1205                 1210                 1215             


Thr Gly  Val Ser Asn Ala Glu  Ala Leu His His Gln  Lys Asp His 
    1220                 1225                 1230             


Leu Gly  Arg Glu Ile Leu Asp  Asp Asn Gly Asn Pro  Ile Pro Ala 
    1235                 1240                 1245             


Asp Phe  Val Ser Thr Gly Asn  Asn His His Val Ala  Ile Tyr Glu 
    1250                 1255                 1260             


Asp Glu  Lys Gly Lys Leu Gln  Glu Lys Val Val Ser  Leu Tyr Glu 
    1265                 1270                 1275             


Ala Val  Ala Arg Ala Asn Gln  Gly Leu Pro Val Val  Asp Lys Gly 
    1280                 1285                 1290             


Leu Asn  Glu Asp Leu Gly Trp  Lys Phe Leu Phe Thr  Met Lys Gln 
    1295                 1300                 1305             


Asn Glu  Met Phe Val Phe Pro  Asn Asp Asp Phe Asp  Val Asn Asp 
    1310                 1315                 1320             


Ile Asp  Leu Leu Asp Glu Asn  Asn Ala Lys Ile Ile  Ser Gln His 
    1325                 1330                 1335             


Leu Phe  Arg Val Gln Lys Leu  Ala Thr Lys Asn Tyr  Met Phe Arg 
    1340                 1345                 1350             


His His  Leu Glu Thr Asn Val  Gln Glu Val Lys Glu  Leu Asn Asp 
    1355                 1360                 1365             


Ile Ala  Tyr Lys Ser Ile Arg  Ser Thr Glu Pro Leu  Lys Asn Ile 
    1370                 1375                 1380             


Lys Lys  Val Arg Ile Asn His  Ile Gly Lys Ile Val  Gln Val Gly 
    1385                 1390                 1395             


Glu Tyr  
    1400 


<210> 413
<211> 1140
<212> PRT
<213> Roseburia intestinalis


<220>
<223> Roseburia intestinalis L1-82

<400> 413
Met Arg Glu Asn Gly Ser Asp Glu Arg Arg Arg Asn Met Asp Glu Lys 
1               5                   10                  15      


Met Asp Tyr Arg Ile Gly Leu Asp Ile Gly Ile Ala Ser Val Gly Trp 
            20                  25                  30          


Ala Val Leu Gln Asn Asn Ser Asp Asp Glu Pro Val Arg Ile Val Asp 
        35                  40                  45              


Leu Gly Val Arg Ile Phe Asp Thr Ala Glu Ile Pro Lys Thr Gly Glu 
    50                  55                  60                  


Ser Leu Ala Gly Pro Arg Arg Ala Ala Arg Thr Thr Arg Arg Arg Leu 
65                  70                  75                  80  


Arg Arg Arg Lys His Arg Leu Asp Arg Ile Lys Trp Leu Phe Glu Asn 
                85                  90                  95      


Gln Gly Leu Ile Asn Ile Asp Asp Phe Leu Lys Arg Tyr Asn Met Ala 
            100                 105                 110         


Gly Leu Pro Asp Val Tyr Gln Leu Arg Tyr Glu Ala Leu Asp Arg Lys 
        115                 120                 125             


Leu Thr Asp Glu Glu Leu Ala Gln Val Leu Leu His Ile Ala Lys His 
    130                 135                 140                 


Arg Gly Phe Arg Ser Thr Arg Lys Ala Glu Thr Ala Ala Lys Glu Asn 
145                 150                 155                 160 


Gly Ala Val Leu Lys Ala Thr Asp Glu Asn Gln Lys Arg Met Gln Glu 
                165                 170                 175     


Lys Gly Tyr Arg Thr Val Gly Glu Met Ile Tyr Leu Asp Glu Ala Phe 
            180                 185                 190         


Arg Thr Gly Cys Ser Trp Ser Glu Lys Gly Tyr Ile Leu Thr Pro Arg 
        195                 200                 205             


Asn Lys Ala Glu Asn Tyr Gln His Thr Met Leu Arg Ala Met Leu Val 
    210                 215                 220                 


Glu Glu Val Lys Glu Ile Phe Ser Ser Gln Arg Arg Leu Gly Asn Glu 
225                 230                 235                 240 


Lys Ala Thr Glu Glu Leu Glu Glu Lys Tyr Leu Glu Ile Met Thr Ser 
                245                 250                 255     


Gln Arg Ser Phe Asp Leu Gly Pro Gly Met Gln Pro Asp Gly Lys Pro 
            260                 265                 270         


Ser Pro Tyr Ala Met Glu Gly Phe Ser Asp Arg Val Gly Lys Cys Thr 
        275                 280                 285             


Phe Leu Gly Asp Gln Gly Glu Leu Arg Gly Ala Lys Gly Thr Tyr Thr 
    290                 295                 300                 


Ala Glu Tyr Phe Val Ala Leu Gln Lys Ile Asn His Thr Lys Leu Val 
305                 310                 315                 320 


Asn Gln Asp Gly Glu Thr Arg Asn Phe Thr Glu Glu Glu Arg Arg Ala 
                325                 330                 335     


Leu Thr Leu Leu Leu Phe Thr Gln Lys Glu Val Lys Tyr Ala Ala Val 
            340                 345                 350         


Arg Lys Lys Leu Gly Leu Pro Glu Asp Ile Leu Phe Tyr Asn Leu Asn 
        355                 360                 365             


Tyr Lys Lys Ala Ala Thr Lys Glu Glu Gln Gln Lys Glu Asn Gln Asn 
    370                 375                 380                 


Thr Glu Lys Ala Lys Phe Ile Gly Met Pro Tyr Tyr His Asp Tyr Lys 
385                 390                 395                 400 


Lys Cys Leu Glu Glu Arg Val Lys Tyr Leu Thr Glu Asn Glu Val Arg 
                405                 410                 415     


Asp Leu Phe Asp Glu Ile Gly Met Ile Leu Thr Cys Tyr Lys Asn Asp 
            420                 425                 430         


Asp Ser Arg Thr Glu Arg Leu Ala Lys Leu Gly Leu Val Pro Ile Glu 
        435                 440                 445             


Met Glu Gly Leu Leu Ala Tyr Thr Pro Thr Lys Phe Gln His Leu Ser 
    450                 455                 460                 


Met Lys Ala Met Arg Asn Ile Ile Pro Phe Leu Glu Lys Gly Met Thr 
465                 470                 475                 480 


Tyr Asp Lys Ala Cys Glu Glu Ala Gly Tyr Asp Phe Lys Ala Asp Ser 
                485                 490                 495     


Lys Gly Thr Lys Gln Lys Leu Leu Thr Gly Glu Asn Val Asn Gln Thr 
            500                 505                 510         


Ile Asn Glu Ile Thr Asn Pro Val Val Lys Arg Ser Val Ser Gln Thr 
        515                 520                 525             


Val Lys Val Ile Asn Ala Ile Ile Arg Thr Tyr Gly Ser Pro Gln Ala 
    530                 535                 540                 


Ile Asn Ile Glu Leu Ala Arg Glu Met Ser Lys Thr Phe Glu Glu Arg 
545                 550                 555                 560 


Arg Lys Ile Lys Gly Asp Met Glu Lys Arg Gln Lys Asn Asn Glu Asp 
                565                 570                 575     


Val Lys Lys Gln Ile Gln Glu Leu Gly Lys Leu Ser Pro Thr Gly Gln 
            580                 585                 590         


Asp Ile Leu Lys Tyr Arg Leu Trp Gln Glu Gln Gln Gly Ile Cys Met 
        595                 600                 605             


Tyr Ser Gly Lys Thr Ile Pro Leu Glu Glu Leu Phe Lys Pro Gly Tyr 
    610                 615                 620                 


Asp Ile Asp His Ile Leu Pro Tyr Ser Ile Thr Phe Asp Asp Ser Phe 
625                 630                 635                 640 


Arg Asn Lys Val Leu Val Thr Ser Gln Glu Asn Arg Gln Lys Gly Asn 
                645                 650                 655     


Arg Thr Pro Tyr Glu Tyr Met Gly Asn Asp Glu Gln Arg Trp Asn Glu 
            660                 665                 670         


Phe Glu Thr Arg Val Lys Thr Thr Ile Arg Asp Tyr Lys Lys Gln Gln 
        675                 680                 685             


Lys Leu Leu Lys Lys His Phe Ser Glu Glu Glu Arg Ser Glu Phe Lys 
    690                 695                 700                 


Glu Arg Asn Leu Thr Asp Thr Lys Tyr Ile Thr Thr Val Ile Tyr Asn 
705                 710                 715                 720 


Met Ile Arg Gln Asn Leu Glu Met Ala Pro Leu Asn Arg Pro Glu Lys 
                725                 730                 735     


Lys Lys Gln Val Arg Ala Val Asn Gly Ala Ile Thr Ala Tyr Leu Arg 
            740                 745                 750         


Lys Arg Trp Gly Leu Pro Gln Lys Asn Arg Glu Thr Asp Thr His His 
        755                 760                 765             


Ala Met Asp Ala Val Val Ile Ala Cys Cys Thr Asp Gly Met Ile Gln 
    770                 775                 780                 


Lys Ile Ser Arg Tyr Thr Lys Val Arg Glu Arg Cys Tyr Ser Lys Gly 
785                 790                 795                 800 


Thr Glu Phe Val Asp Ala Glu Thr Gly Glu Ile Phe Arg Pro Glu Asp 
                805                 810                 815     


Tyr Ser Arg Ala Glu Trp Asp Glu Ile Phe Gly Val His Ile Pro Lys 
            820                 825                 830         


Pro Trp Glu Thr Phe Arg Ala Glu Leu Asp Val Arg Met Gly Asp Asp 
        835                 840                 845             


Pro Lys Gly Phe Leu Asp Thr His Ser Asp Val Ala Leu Glu Leu Asp 
    850                 855                 860                 


Tyr Pro Glu Tyr Ile Tyr Glu Asn Leu Arg Pro Ile Phe Val Ser Arg 
865                 870                 875                 880 


Met Pro Asn His Lys Val Thr Gly Ala Ala His Ala Asp Thr Ile Arg 
                885                 890                 895     


Ser Pro Arg His Phe Lys Asp Glu Gly Ile Val Leu Thr Lys Thr Ala 
            900                 905                 910         


Leu Thr Asp Leu Lys Leu Asp Lys Asp Gly Glu Ile Asp Gly Tyr Tyr 
        915                 920                 925             


Asn Pro Gln Ser Asp Leu Leu Leu Tyr Glu Ala Leu Lys Lys Gln Leu 
    930                 935                 940                 


Leu Leu Tyr Gly Asn Asp Ala Lys Lys Ala Phe Ala Gln Asp Phe His 
945                 950                 955                 960 


Lys Pro Lys Ala Asp Gly Thr Glu Gly Pro Val Val Arg Lys Val Lys 
                965                 970                 975     


Ile Gln Lys Lys Gln Thr Met Gly Val Phe Val Asp Ser Gly Asn Gly 
            980                 985                 990         


Ile Ala Glu Asn Gly Gly Met Val  Arg Ile Asp Val Phe  Arg Val Asn 
        995                 1000                 1005             


Gly Lys  Tyr Tyr Phe Val Pro  Val Tyr Thr Ala Asp  Val Val Lys 
    1010                 1015                 1020             


Lys Val  Leu Pro Asn Arg Ala  Ser Thr Ala His Lys  Pro Tyr Gly 
    1025                 1030                 1035             


Glu Trp  Lys Val Met Glu Asp  Lys Asp Phe Leu Phe  Ser Leu Tyr 
    1040                 1045                 1050             


Ser Arg  Asp Leu Ile His Ile  Lys Ser Lys Lys Asp  Ile Pro Ile 
    1055                 1060                 1065             


Lys Met  Val Asn Gly Gly Met  Glu Gly Ile Lys Glu  Thr Tyr Ala 
    1070                 1075                 1080             


Tyr Tyr  Ile Gly Ala Asp Ile  Ser Ala Ala Asn Ile  Gln Gly Ile 
    1085                 1090                 1095             


Ala His  Asp Ser Arg Tyr Lys  Phe Arg Gly Leu Gly  Ile Gln Ser 
    1100                 1105                 1110             


Leu Asp  Val Leu Glu Lys Cys  Gln Ile Asp Val Leu  Gly His Val 
    1115                 1120                 1125             


Ser Val  Val Arg Ser Glu Lys  Arg Met Gly Phe Ser  
    1130                 1135                 1140 


<210> 414
<211> 1128
<212> PRT
<213> Roseburia intestinalis


<220>
<223> Roseburia intestinalis M50/1

<400> 414
Met Asp Glu Lys Met Asp Tyr Arg Ile Gly Leu Asp Ile Gly Ile Ala 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Leu Gln Asn Asn Ser Asp Asp Glu Pro Val 
            20                  25                  30          


Arg Ile Val Asp Leu Gly Val Arg Ile Phe Asp Thr Ala Glu Ile Pro 
        35                  40                  45              


Lys Thr Gly Glu Ser Leu Ala Gly Pro Arg Arg Ala Ala Arg Thr Thr 
    50                  55                  60                  


Arg Arg Arg Leu Arg Arg Arg Lys His Arg Leu Asp Arg Ile Lys Trp 
65                  70                  75                  80  


Leu Phe Glu Asn Gln Gly Leu Ile Asn Ile Asp Asp Phe Leu Lys Arg 
                85                  90                  95      


Tyr Asn Met Ala Gly Leu Pro Asp Val Tyr Gln Leu Arg Tyr Glu Ala 
            100                 105                 110         


Leu Asp Arg Lys Leu Thr Asp Glu Glu Leu Ala Gln Val Leu Leu His 
        115                 120                 125             


Ile Ala Lys His Arg Gly Phe Arg Ser Thr Arg Lys Ala Glu Thr Ala 
    130                 135                 140                 


Ala Lys Glu Asn Gly Ala Val Leu Lys Ala Thr Asp Glu Asn Gln Lys 
145                 150                 155                 160 


Arg Met Gln Glu Lys Gly Tyr Arg Thr Val Gly Glu Met Ile Tyr Leu 
                165                 170                 175     


Asp Glu Ala Phe Arg Ile Gly Cys Ser Trp Ser Glu Lys Gly Tyr Ile 
            180                 185                 190         


Leu Thr Pro Arg Asn Lys Ala Glu Asn Tyr Gln His Thr Met Leu Arg 
        195                 200                 205             


Ala Met Leu Val Glu Glu Val Lys Glu Ile Phe Ser Ser Gln Arg Arg 
    210                 215                 220                 


Leu Gly Asn Lys Lys Ala Thr Glu Glu Leu Glu Glu Lys Tyr Leu Glu 
225                 230                 235                 240 


Ile Met Thr Ser Gln Arg Ser Phe Asp Leu Gly Pro Gly Met Gln Pro 
                245                 250                 255     


Asp Gly Lys Pro Ser Pro Tyr Ala Met Glu Gly Phe Ser Asp Arg Val 
            260                 265                 270         


Gly Lys Cys Thr Phe Leu Gly Asp Gln Gly Glu Leu Arg Gly Ala Lys 
        275                 280                 285             


Gly Thr Tyr Thr Ala Glu Tyr Phe Val Ala Leu Gln Lys Ile Asn His 
    290                 295                 300                 


Thr Lys Leu Val Asn Gln Asp Gly Glu Thr Arg Asn Phe Thr Glu Glu 
305                 310                 315                 320 


Glu Arg Arg Ala Leu Thr Leu Leu Leu Phe Thr Gln Lys Glu Val Lys 
                325                 330                 335     


Tyr Ala Ala Val Arg Lys Lys Leu Gly Leu Pro Glu Asp Ile Leu Phe 
            340                 345                 350         


Tyr Asn Leu Asn Tyr Lys Lys Ala Ala Thr Lys Glu Glu Gln Gln Lys 
        355                 360                 365             


Glu Asn Gln Asn Thr Glu Lys Ala Lys Phe Ile Gly Met Pro Tyr Tyr 
    370                 375                 380                 


His Asp Tyr Lys Lys Cys Leu Glu Glu Arg Val Lys Tyr Leu Thr Glu 
385                 390                 395                 400 


Asn Glu Val Arg Asp Leu Phe Asp Glu Ile Gly Met Ile Leu Thr Cys 
                405                 410                 415     


Tyr Lys Asn Asp Asp Ser Arg Thr Glu Arg Leu Ala Lys Leu Gly Leu 
            420                 425                 430         


Val Pro Ile Glu Met Glu Gly Leu Leu Ala Tyr Thr Pro Thr Lys Phe 
        435                 440                 445             


Gln His Leu Ser Met Lys Ala Met Arg Asn Ile Ile Pro Phe Leu Glu 
    450                 455                 460                 


Lys Gly Met Thr Tyr Asp Lys Ala Cys Glu Glu Ala Gly Tyr Asp Phe 
465                 470                 475                 480 


Lys Ala Asp Ser Lys Gly Thr Lys Gln Lys Leu Leu Thr Gly Glu Asn 
                485                 490                 495     


Val Asn Gln Thr Ile Asn Glu Ile Thr Asn Pro Val Val Lys Arg Ser 
            500                 505                 510         


Val Ser Gln Thr Val Lys Val Ile Asn Ala Ile Ile Arg Thr Tyr Gly 
        515                 520                 525             


Ser Pro Gln Ala Ile Asn Ile Glu Leu Ala Arg Glu Met Ser Lys Thr 
    530                 535                 540                 


Phe Glu Glu Arg Arg Lys Ile Lys Gly Asp Met Glu Lys Arg Gln Lys 
545                 550                 555                 560 


Asn Asn Glu Asp Val Lys Lys Gln Ile Gln Glu Leu Gly Lys Leu Ser 
                565                 570                 575     


Pro Thr Gly Gln Asp Ile Leu Lys Tyr Arg Leu Trp Gln Glu Gln Gln 
            580                 585                 590         


Gly Ile Cys Met Tyr Ser Gly Lys Thr Ile Pro Leu Glu Glu Leu Phe 
        595                 600                 605             


Lys Pro Gly Tyr Asp Ile Asp His Ile Leu Pro Tyr Ser Ile Thr Phe 
    610                 615                 620                 


Asp Asp Ser Phe Arg Asn Lys Val Leu Val Thr Ser Gln Glu Asn Arg 
625                 630                 635                 640 


Gln Lys Gly Asn Arg Thr Pro Tyr Glu Tyr Met Gly Asn Asp Glu Gln 
                645                 650                 655     


Arg Trp Asn Glu Phe Glu Thr Arg Val Lys Thr Thr Ile Arg Asp Tyr 
            660                 665                 670         


Lys Lys Gln Gln Lys Leu Leu Lys Lys His Phe Ser Glu Glu Glu Arg 
        675                 680                 685             


Ser Glu Phe Lys Glu Arg Asn Leu Thr Asp Thr Lys Tyr Ile Thr Thr 
    690                 695                 700                 


Val Ile Tyr Asn Met Ile Arg Gln Asn Leu Glu Met Ala Pro Leu Asn 
705                 710                 715                 720 


Arg Pro Glu Lys Lys Lys Gln Val Arg Ala Val Asn Gly Ala Ile Thr 
                725                 730                 735     


Ala Tyr Leu Arg Lys Arg Trp Gly Leu Pro Gln Lys Asn Arg Glu Thr 
            740                 745                 750         


Asp Thr His His Ala Met Asp Ala Val Val Ile Ala Cys Cys Thr Asp 
        755                 760                 765             


Gly Met Ile Gln Lys Ile Ser Arg Tyr Thr Lys Val Arg Glu Arg Cys 
    770                 775                 780                 


Tyr Ser Lys Gly Thr Glu Phe Val Asp Ala Glu Thr Gly Glu Ile Phe 
785                 790                 795                 800 


Arg Pro Glu Asp Tyr Ser Arg Ala Glu Trp Asp Glu Ile Phe Gly Val 
                805                 810                 815     


His Ile Pro Lys Pro Trp Glu Thr Phe Arg Ala Glu Leu Asp Val Arg 
            820                 825                 830         


Met Gly Asp Asp Pro Lys Gly Phe Leu Asp Thr His Ser Asp Val Ala 
        835                 840                 845             


Leu Glu Leu Asp Tyr Pro Glu Tyr Ile Tyr Glu Asn Leu Arg Pro Ile 
    850                 855                 860                 


Phe Val Ser Arg Met Pro Asn His Lys Val Thr Gly Ala Ala His Ala 
865                 870                 875                 880 


Asp Thr Ile Arg Ser Pro Arg His Phe Lys Asp Glu Gly Ile Val Leu 
                885                 890                 895     


Thr Lys Thr Ala Leu Thr Asp Leu Lys Leu Asp Lys Asp Gly Glu Ile 
            900                 905                 910         


Asp Gly Tyr Tyr Asn Pro Gln Ser Asp Leu Leu Leu Tyr Glu Ala Leu 
        915                 920                 925             


Lys Lys Gln Leu Leu Leu Tyr Gly Asn Asp Ala Lys Lys Ala Phe Ala 
    930                 935                 940                 


Gln Asp Phe His Lys Pro Lys Ala Asp Gly Thr Glu Gly Pro Val Val 
945                 950                 955                 960 


Arg Lys Val Lys Ile Gln Lys Lys Gln Thr Met Gly Val Phe Val Asp 
                965                 970                 975     


Ser Gly Asn Gly Ile Ala Glu Asn Gly Gly Met Val Arg Ile Asp Val 
            980                 985                 990         


Phe Arg Val Asn Gly Lys Tyr Tyr  Phe Val Pro Val Tyr  Thr Ala Asp 
        995                 1000                 1005             


Val Val  Lys Lys Val Leu Pro  Asn Arg Ala Ser Thr  Ala Asn Lys 
    1010                 1015                 1020             


Pro Tyr  Ser Glu Trp Arg Thr  Met Glu Asp Lys Asp  Phe Leu Phe 
    1025                 1030                 1035             


Ser Leu  Tyr Ser Arg Asp Leu  Val His Ile Lys Ser  Lys Lys Gly 
    1040                 1045                 1050             


Ile Pro  Ile Lys Asn Val Asp  Gly Ser Leu Gly Glu  Ser Lys Glu 
    1055                 1060                 1065             


Val Tyr  Ala Tyr Tyr Ile Gly  Ala Asp Ile Ser Gly  Ala Lys Ile 
    1070                 1075                 1080             


Glu Gly  Lys Ala His Asp Ser  Arg Tyr Thr Phe Arg  Gly Ile Gly 
    1085                 1090                 1095             


Val Gln  Lys Leu Glu Leu Ile  Glu Lys Cys Gln Val  Asp Ile Leu 
    1100                 1105                 1110             


Gly His  Ile Ser Thr Val Lys  Asn Glu Lys Arg Met  Gly Phe Ser 
    1115                 1120                 1125             


<210> 415
<211> 1152
<212> PRT
<213> Roseburia inulinivorans


<220>
<223> Roseburia inulinivorans DSM 16841

<400> 415
Met Asn Ala Glu His Gly Lys Glu Gly Leu Leu Ile Met Glu Glu Asn 
1               5                   10                  15      


Phe Gln Tyr Arg Ile Gly Leu Asp Ile Gly Ile Thr Ser Val Gly Trp 
            20                  25                  30          


Ala Val Leu Gln Asn Asn Ser Gln Asp Glu Pro Val Arg Ile Thr Asp 
        35                  40                  45              


Leu Gly Val Arg Ile Phe Asp Val Ala Glu Asn Pro Lys Asn Gly Asp 
    50                  55                  60                  


Ala Leu Ala Ala Pro Arg Arg Asp Ala Arg Thr Thr Arg Arg Arg Leu 
65                  70                  75                  80  


Arg Arg Arg Arg His Arg Leu Glu Arg Ile Lys Phe Leu Leu Gln Glu 
                85                  90                  95      


Asn Gly Leu Ile Glu Met Asp Ser Phe Met Glu Arg Tyr Tyr Lys Gly 
            100                 105                 110         


Asn Leu Pro Asp Val Tyr Gln Leu Arg Tyr Glu Gly Leu Asp Arg Lys 
        115                 120                 125             


Leu Lys Asp Glu Glu Leu Ala Gln Val Leu Ile His Ile Ala Lys His 
    130                 135                 140                 


Arg Gly Phe Arg Ser Thr Arg Lys Ala Glu Thr Lys Glu Lys Glu Gly 
145                 150                 155                 160 


Gly Ala Val Leu Lys Ala Thr Thr Glu Asn Gln Lys Ile Met Gln Glu 
                165                 170                 175     


Lys Gly Tyr Arg Thr Val Gly Glu Met Leu Tyr Leu Asp Glu Ala Phe 
            180                 185                 190         


His Thr Glu Cys Leu Trp Asn Glu Lys Gly Tyr Val Leu Thr Pro Arg 
        195                 200                 205             


Asn Arg Pro Asp Asp Tyr Lys His Thr Ile Leu Arg Ser Met Leu Val 
    210                 215                 220                 


Glu Glu Val His Ala Ile Phe Ala Ala Gln Arg Ala His Gly Asn Gln 
225                 230                 235                 240 


Lys Ala Thr Glu Gly Leu Glu Glu Ala Tyr Val Glu Ile Met Thr Ser 
                245                 250                 255     


Gln Arg Ser Phe Asp Met Gly Pro Gly Leu Gln Pro Asp Gly Lys Pro 
            260                 265                 270         


Ser Pro Tyr Ala Met Glu Gly Phe Gly Asp Arg Val Gly Lys Cys Thr 
        275                 280                 285             


Phe Glu Lys Asp Glu Tyr Arg Ala Pro Lys Ala Thr Tyr Thr Ala Glu 
    290                 295                 300                 


Leu Phe Val Ala Leu Gln Lys Ile Asn His Thr Lys Leu Ile Asp Glu 
305                 310                 315                 320 


Phe Gly Thr Gly Arg Phe Phe Ser Glu Glu Glu Arg Lys Thr Ile Ile 
                325                 330                 335     


Gly Leu Leu Leu Ser Ser Lys Glu Leu Lys Tyr Gly Thr Ile Arg Lys 
            340                 345                 350         


Lys Leu Asn Ile Asp Pro Ser Leu Lys Phe Asn Ser Leu Asn Tyr Ser 
        355                 360                 365             


Ala Lys Lys Glu Gly Glu Thr Glu Glu Glu Arg Val Leu Asp Thr Glu 
    370                 375                 380                 


Lys Ala Lys Phe Ala Ser Met Phe Trp Thr Tyr Glu Tyr Ser Lys Cys 
385                 390                 395                 400 


Leu Lys Asp Arg Thr Glu Glu Met Pro Val Gly Glu Lys Ala Asp Leu 
                405                 410                 415     


Phe Asp Arg Ile Gly Glu Ile Leu Thr Ala Tyr Lys Asn Asp Asp Ser 
            420                 425                 430         


Arg Ser Ser Arg Leu Lys Glu Leu Gly Leu Ser Gly Glu Glu Ile Asp 
        435                 440                 445             


Gly Leu Leu Asp Leu Ser Pro Ala Lys Tyr Gln Arg Val Ser Leu Lys 
    450                 455                 460                 


Ala Met Arg Lys Met Gln Pro Tyr Leu Glu Asp Gly Leu Ile Tyr Asp 
465                 470                 475                 480 


Lys Ala Cys Glu Ala Ala Gly Tyr Asp Phe Arg Ala Leu Asn Asp Gly 
                485                 490                 495     


Asn Lys Lys His Leu Leu Lys Gly Glu Glu Ile Asn Ala Ile Val Asn 
            500                 505                 510         


Asp Ile Thr Asn Pro Val Val Lys Arg Ser Val Ser Gln Thr Ile Lys 
        515                 520                 525             


Val Ile Asn Ala Ile Ile Gln Lys Tyr Gly Ser Pro Gln Ala Val Asn 
    530                 535                 540                 


Ile Glu Leu Ala Arg Glu Met Ser Lys Asn Phe Gln Asp Arg Thr Asn 
545                 550                 555                 560 


Leu Glu Lys Glu Met Lys Lys Arg Gln Gln Glu Asn Glu Arg Ala Lys 
                565                 570                 575     


Gln Gln Ile Ile Glu Leu Gly Lys Gln Asn Pro Thr Gly Gln Asp Ile 
            580                 585                 590         


Leu Lys Tyr Arg Leu Trp Asn Asp Gln Gly Gly Tyr Cys Leu Tyr Ser 
        595                 600                 605             


Gly Lys Lys Ile Pro Leu Glu Glu Leu Phe Asp Gly Gly Tyr Asp Ile 
    610                 615                 620                 


Asp His Ile Leu Pro Tyr Ser Ile Thr Phe Asp Asp Ser Tyr Arg Asn 
625                 630                 635                 640 


Lys Val Leu Val Thr Ala Gln Glu Asn Arg Gln Lys Gly Asn Arg Thr 
                645                 650                 655     


Pro Tyr Glu Tyr Phe Gly Ala Asp Glu Lys Arg Trp Glu Asp Tyr Glu 
            660                 665                 670         


Ala Ser Val Arg Leu Leu Val Arg Asp Tyr Lys Lys Gln Gln Lys Leu 
        675                 680                 685             


Leu Lys Lys Asn Phe Thr Glu Glu Glu Arg Lys Glu Phe Lys Glu Arg 
    690                 695                 700                 


Asn Leu Asn Asp Thr Lys Tyr Ile Thr Arg Val Val Tyr Asn Met Ile 
705                 710                 715                 720 


Arg Gln Asn Leu Glu Leu Glu Pro Phe Asn His Pro Glu Lys Lys Lys 
                725                 730                 735     


Gln Val Trp Ala Val Asn Gly Ala Val Thr Ser Tyr Leu Arg Lys Arg 
            740                 745                 750         


Trp Gly Leu Met Gln Lys Asp Arg Ser Thr Asp Arg His His Ala Met 
        755                 760                 765             


Asp Ala Val Val Ile Ala Cys Cys Thr Asp Gly Met Ile His Lys Ile 
    770                 775                 780                 


Ser Arg Tyr Met Gln Gly Arg Glu Leu Ala Tyr Ser Arg Asn Phe Lys 
785                 790                 795                 800 


Phe Pro Asp Glu Glu Thr Gly Glu Ile Leu Asn Arg Asp Asn Phe Thr 
                805                 810                 815     


Arg Glu Gln Trp Asp Glu Lys Phe Gly Val Lys Val Pro Leu Pro Trp 
            820                 825                 830         


Asn Ser Phe Arg Asp Glu Leu Asp Ile Arg Leu Leu Asn Glu Asp Pro 
        835                 840                 845             


Lys Asn Phe Leu Leu Thr His Ala Asp Val Gln Arg Glu Leu Asp Tyr 
    850                 855                 860                 


Pro Gly Trp Met Tyr Gly Glu Glu Glu Ser Pro Ile Glu Glu Gly Arg 
865                 870                 875                 880 


Tyr Ile Asn Tyr Ile Arg Pro Leu Phe Val Ser Arg Met Pro Asn His 
                885                 890                 895     


Lys Val Thr Gly Ser Ala His Asp Ala Thr Ile Arg Ser Ala Arg Asp 
            900                 905                 910         


Tyr Glu Thr Arg Gly Val Val Ile Thr Lys Val Pro Leu Thr Asp Leu 
        915                 920                 925             


Lys Leu Asn Lys Asp Asn Glu Ile Glu Gly Tyr Tyr Asp Lys Asp Ser 
    930                 935                 940                 


Asp Arg Leu Leu Tyr Gln Ala Leu Val Arg Gln Leu Leu Leu His Gly 
945                 950                 955                 960 


Asn Asp Gly Lys Lys Ala Phe Ala Glu Asp Phe His Lys Pro Lys Ala 
                965                 970                 975     


Asp Gly Thr Glu Gly Pro Val Val Arg Lys Val Lys Ile Glu Lys Lys 
            980                 985                 990         


Gln Thr Ser Gly Val Met Val Arg  Gly Gly Thr Gly Ile  Ala Ala Asn 
        995                 1000                 1005             


Gly Glu  Met Val Arg Ile Asp  Val Phe Arg Glu Asn  Gly Lys Tyr 
    1010                 1015                 1020             


Tyr Phe  Val Pro Val Tyr Thr  Ala Asp Val Val Arg  Lys Val Leu 
    1025                 1030                 1035             


Pro Asn  Arg Ala Ala Thr His  Thr Lys Pro Tyr Ser  Glu Trp Arg 
    1040                 1045                 1050             


Val Met  Asp Asp Ala Asn Phe  Val Phe Ser Leu Tyr  Ser Arg Asp 
    1055                 1060                 1065             


Leu Ile  His Val Lys Ser Lys  Lys Asp Ile Lys Thr  Asn Leu Val 
    1070                 1075                 1080             


Asn Gly  Gly Leu Leu Leu Gln  Lys Glu Ile Phe Ala  Tyr Tyr Thr 
    1085                 1090                 1095             


Gly Ala  Asp Ile Ala Thr Ala  Ser Ile Ala Gly Phe  Ala Asn Asp 
    1100                 1105                 1110             


Ser Asn  Phe Lys Phe Arg Gly  Leu Gly Ile Gln Ser  Leu Glu Ile 
    1115                 1120                 1125             


Phe Glu  Lys Cys Gln Val Asp  Ile Leu Gly Asn Ile  Ser Val Val 
    1130                 1135                 1140             


Arg His  Glu Asn Arg Gln Glu  Phe His 
    1145                 1150         


<210> 416
<211> 1156
<212> PRT
<213> Ruminococcus albus


<220>
<223> Ruminococcus albus 8

<400> 416
Met Gly Asn Tyr Tyr Leu Gly Leu Asp Val Gly Ile Gly Ser Ile Gly 
1               5                   10                  15      


Trp Ala Val Ile Asn Ile Glu Lys Lys Arg Ile Glu Asp Phe Asn Val 
            20                  25                  30          


Arg Ile Phe Lys Ser Gly Glu Ile Gln Glu Lys Asn Arg Asn Ser Arg 
        35                  40                  45              


Ala Ser Gln Gln Cys Arg Arg Ser Arg Gly Leu Arg Arg Leu Tyr Arg 
    50                  55                  60                  


Arg Lys Ser His Arg Lys Leu Arg Leu Lys Asn Tyr Leu Ser Ile Ile 
65                  70                  75                  80  


Gly Leu Thr Thr Ser Glu Lys Ile Asp Tyr Tyr Tyr Glu Thr Ala Asp 
                85                  90                  95      


Asn Asn Val Ile Gln Leu Arg Asn Lys Gly Leu Ser Glu Lys Leu Thr 
            100                 105                 110         


Pro Glu Glu Ile Ala Ala Cys Leu Ile His Ile Cys Asn Asn Arg Gly 
        115                 120                 125             


Tyr Lys Asp Phe Tyr Glu Val Asn Val Glu Asp Ile Glu Asp Pro Asp 
    130                 135                 140                 


Glu Arg Asn Glu Tyr Lys Glu Glu His Asp Ser Ile Val Leu Ile Ser 
145                 150                 155                 160 


Asn Leu Met Asn Glu Gly Gly Tyr Cys Thr Pro Ala Glu Met Ile Cys 
                165                 170                 175     


Asn Cys Arg Glu Phe Asp Glu Pro Asn Ser Val Tyr Arg Lys Phe His 
            180                 185                 190         


Asn Ser Ala Ala Ser Lys Asn His Tyr Leu Ile Thr Arg His Met Leu 
        195                 200                 205             


Val Lys Glu Val Asp Leu Ile Leu Glu Asn Gln Ser Lys Tyr Tyr Gly 
    210                 215                 220                 


Ile Leu Asp Asp Lys Thr Ile Ala Lys Ile Lys Asp Ile Ile Phe Ala 
225                 230                 235                 240 


Gln Arg Asp Phe Glu Ile Gly Pro Gly Lys Asn Glu Arg Phe Arg Arg 
                245                 250                 255     


Phe Thr Gly Tyr Leu Asp Ser Ile Gly Lys Cys Gln Phe Phe Lys Asp 
            260                 265                 270         


Gln Glu Arg Gly Ser Arg Phe Thr Val Ile Ala Asp Ile Tyr Ala Phe 
        275                 280                 285             


Val Asn Val Leu Ser Gln Tyr Thr Tyr Thr Asn Asn Arg Gly Glu Ser 
    290                 295                 300                 


Val Phe Asp Thr Ser Phe Ala Asn Asp Leu Ile Asn Ser Ala Leu Lys 
305                 310                 315                 320 


Asn Gly Ser Met Asp Lys Arg Glu Leu Lys Ala Ile Ala Lys Ser Tyr 
                325                 330                 335     


His Ile Asp Ile Ser Asp Lys Asn Ser Asp Thr Ser Leu Thr Lys Cys 
            340                 345                 350         


Phe Lys Tyr Ile Lys Val Val Lys Pro Leu Phe Glu Lys Tyr Gly Tyr 
        355                 360                 365             


Asp Trp Asp Lys Leu Ile Glu Asn Tyr Thr Asp Thr Asp Asn Asn Val 
    370                 375                 380                 


Leu Asn Arg Ile Gly Ile Val Leu Ser Gln Ala Gln Thr Pro Lys Arg 
385                 390                 395                 400 


Arg Arg Glu Lys Leu Lys Ala Leu Asn Ile Gly Leu Asp Asp Gly Leu 
                405                 410                 415     


Ile Asn Glu Leu Thr Lys Leu Lys Leu Ser Gly Thr Ala Asn Val Ser 
            420                 425                 430         


Tyr Lys Tyr Met Gln Gly Ser Ile Glu Ala Phe Cys Glu Gly Asp Leu 
        435                 440                 445             


Tyr Gly Lys Tyr Gln Ala Lys Phe Asn Lys Glu Ile Pro Asp Ile Asp 
    450                 455                 460                 


Glu Asn Ala Lys Pro Gln Lys Leu Pro Pro Phe Lys Asn Glu Asp Asp 
465                 470                 475                 480 


Cys Glu Phe Phe Lys Asn Pro Val Val Phe Arg Ser Ile Asn Glu Thr 
                485                 490                 495     


Arg Lys Leu Ile Asn Ala Ile Ile Asp Lys Tyr Gly Tyr Pro Ala Ala 
            500                 505                 510         


Val Asn Ile Glu Thr Ala Asp Glu Leu Asn Lys Thr Phe Glu Asp Arg 
        515                 520                 525             


Ala Ile Asp Thr Lys Arg Asn Asn Asp Asn Gln Lys Glu Asn Asp Arg 
    530                 535                 540                 


Ile Val Lys Glu Ile Ile Glu Cys Ile Lys Cys Asp Glu Val His Ala 
545                 550                 555                 560 


Arg His Leu Ile Glu Lys Tyr Lys Leu Trp Glu Ala Gln Glu Gly Lys 
                565                 570                 575     


Cys Leu Tyr Ser Gly Glu Thr Ile Thr Lys Glu Asp Met Leu Arg Asp 
            580                 585                 590         


Lys Asp Lys Leu Phe Glu Val Asp His Ile Val Pro Tyr Ser Leu Ile 
        595                 600                 605             


Leu Asp Asn Thr Ile Asn Asn Lys Ala Leu Val Tyr Ala Glu Glu Asn 
    610                 615                 620                 


Gln Lys Lys Gly Gln Arg Thr Pro Leu Met Tyr Met Asn Glu Ala Gln 
625                 630                 635                 640 


Ala Ala Asp Tyr Arg Val Arg Val Asn Thr Met Phe Lys Ser Lys Lys 
                645                 650                 655     


Cys Ser Lys Lys Lys Tyr Gln Tyr Leu Met Leu Pro Asp Leu Asn Asp 
            660                 665                 670         


Gln Glu Leu Leu Gly Gly Trp Arg Ser Arg Asn Leu Asn Asp Thr Arg 
        675                 680                 685             


Tyr Ile Cys Lys Tyr Leu Val Asn Tyr Leu Arg Lys Asn Leu Arg Phe 
    690                 695                 700                 


Asp Arg Ser Tyr Glu Ser Ser Asp Glu Asp Asp Leu Lys Ile Arg Asp 
705                 710                 715                 720 


His Tyr Arg Val Phe Pro Val Lys Ser Arg Phe Thr Ser Met Phe Arg 
                725                 730                 735     


Arg Trp Trp Leu Asn Glu Lys Thr Trp Gly Arg Tyr Asp Lys Ala Glu 
            740                 745                 750         


Leu Lys Lys Leu Thr Tyr Leu Asp His Ala Ala Asp Ala Ile Ile Ile 
        755                 760                 765             


Ala Asn Cys Arg Pro Glu Tyr Val Val Leu Ala Gly Glu Lys Leu Lys 
    770                 775                 780                 


Leu Asn Lys Met Tyr His Gln Ala Gly Lys Arg Ile Thr Pro Glu Tyr 
785                 790                 795                 800 


Glu Gln Ser Lys Lys Ala Cys Ile Asp Asn Leu Tyr Lys Leu Phe Arg 
                805                 810                 815     


Met Asp Arg Arg Thr Ala Glu Lys Leu Leu Ser Gly His Gly Arg Leu 
            820                 825                 830         


Thr Pro Ile Ile Pro Asn Leu Ser Glu Glu Val Asp Lys Arg Leu Trp 
        835                 840                 845             


Asp Lys Asn Ile Tyr Glu Gln Phe Trp Lys Asp Asp Lys Asp Lys Lys 
    850                 855                 860                 


Ser Cys Glu Glu Leu Tyr Arg Glu Asn Val Ala Ser Leu Tyr Lys Gly 
865                 870                 875                 880 


Asp Pro Lys Phe Ala Ser Ser Leu Ser Met Pro Val Ile Ser Leu Lys 
                885                 890                 895     


Pro Asp His Lys Tyr Arg Gly Thr Ile Thr Gly Glu Glu Ala Ile Arg 
            900                 905                 910         


Val Lys Glu Ile Asp Gly Lys Leu Ile Lys Leu Lys Arg Lys Ser Ile 
        915                 920                 925             


Ser Glu Ile Thr Ala Glu Ser Ile Asn Ser Ile Tyr Thr Asp Asp Lys 
    930                 935                 940                 


Ile Leu Ile Asp Ser Leu Lys Thr Ile Phe Glu Gln Ala Asp Tyr Lys 
945                 950                 955                 960 


Asp Val Gly Asp Tyr Leu Lys Lys Thr Asn Gln His Phe Phe Thr Thr 
                965                 970                 975     


Ser Ser Gly Lys Arg Val Asn Lys Val Thr Val Ile Glu Lys Val Pro 
            980                 985                 990         


Ser Arg Trp Leu Arg Lys Glu Ile  Asp Asp Asn Asn Phe  Ser Leu Leu 
        995                 1000                 1005             


Asn Asp  Ser Ser Tyr Tyr Cys  Ile Glu Leu Tyr Lys  Asp Ser Lys 
    1010                 1015                 1020             


Gly Asp  Asn Asn Leu Gln Gly  Ile Ala Met Ser Asp  Ile Val His 
    1025                 1030                 1035             


Asp Arg  Lys Thr Lys Lys Leu  Tyr Leu Lys Pro Asp  Phe Asn Tyr 
    1040                 1045                 1050             


Pro Asp  Asp Tyr Tyr Thr His  Val Met Tyr Ile Phe  Pro Gly Asp 
    1055                 1060                 1065             


Tyr Leu  Arg Ile Lys Ser Thr  Ser Lys Lys Ser Gly  Glu Gln Leu 
    1070                 1075                 1080             


Lys Phe  Glu Gly Tyr Phe Ile  Ser Val Lys Asn Val  Asn Glu Asn 
    1085                 1090                 1095             


Ser Phe  Arg Phe Ile Ser Asp  Asn Lys Pro Cys Ala  Lys Asp Lys 
    1100                 1105                 1110             


Arg Val  Ser Ile Thr Lys Lys  Asp Ile Val Ile Lys  Leu Ala Val 
    1115                 1120                 1125             


Asp Leu  Met Gly Lys Val Gln  Gly Glu Asn Asn Gly  Lys Gly Ile 
    1130                 1135                 1140             


Ser Cys  Gly Glu Pro Leu Ser  Leu Leu Lys Glu Lys  Asn 
    1145                 1150                 1155     


<210> 417
<211> 1341
<212> PRT
<213> Ruminococcus lactaris


<220>
<223> Ruminococcus lactaris ATCC 29176

<400> 417
Met Gly Lys Gly Tyr Tyr Val Gly Leu Asp Met Gly Thr Gly Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Thr Asp Glu Ser Tyr Gln Ile Leu Arg Arg His Gly 
            20                  25                  30          


Lys Ala Met Trp Gly Val Arg Leu Phe Glu Ser Ala Lys Thr Ala Glu 
        35                  40                  45              


Glu Arg Arg Met Phe Arg Thr Gly Arg Arg Arg Leu Asp Arg Arg Gly 
    50                  55                  60                  


Trp Arg Ile Glu Ile Leu Gln Glu Ile Phe Ala Glu Glu Ile Ser Arg 
65                  70                  75                  80  


Val Asp Pro Gly Phe Phe Leu Arg Met Lys Glu Ser Lys Tyr Tyr Pro 
                85                  90                  95      


Glu Asp Lys Arg Asp Ile Gln Gly Asn Cys Pro Glu Leu Pro Tyr Thr 
            100                 105                 110         


Leu Phe Val Asp Lys Thr Phe Thr Asp Lys Asp Phe His Lys Lys Tyr 
        115                 120                 125             


Pro Thr Ile Tyr His Leu Arg Lys Met Leu Met Glu Thr Glu Asp Thr 
    130                 135                 140                 


Pro Asp Met Arg Leu Val Tyr Leu Ala Leu His His Met Met Lys His 
145                 150                 155                 160 


Arg Gly His Phe Leu Leu Ser Gly Asp Ile Ser Gln Val Thr Glu Phe 
                165                 170                 175     


Lys Asn Thr Phe Asn Gln Phe Ile Glu Asn Ile Arg Asn Glu Glu Met 
            180                 185                 190         


Asp Phe Glu Ile Glu Leu Asp Glu Ser Ala Val Gln Met Ile Glu Glu 
        195                 200                 205             


Thr Leu Lys Asp Lys Asn Leu Thr Arg Ser Ala Lys Lys Ser Lys Leu 
    210                 215                 220                 


Val Lys Gly Leu Asn Ala Lys Asn Val Arg Asp Lys Ala Phe Leu Thr 
225                 230                 235                 240 


Leu Leu Ser Gly Gly Thr Val Lys Leu Ser Asp Leu Phe Gly Met Glu 
                245                 250                 255     


Glu Leu Asn Glu Gly Glu Arg Pro Lys Ile Ser Phe Ala Asp Asn Gly 
            260                 265                 270         


Tyr Glu Glu Tyr Ala Ala Val Val Glu Met Glu Leu Gly Glu Leu Tyr 
        275                 280                 285             


Tyr Ile Val Glu Ser Ala Lys Ala Val Tyr Asp Trp Ala Ile Leu Ser 
    290                 295                 300                 


Asp Ile Leu Gly Gly Ser Thr Ser Val Ser Asp Ala Lys Val Arg Ala 
305                 310                 315                 320 


Tyr Glu Lys His Lys Ala Asp Leu Lys Tyr Leu Lys Ala Val Val Lys 
                325                 330                 335     


Glu Tyr Phe Pro Lys Glu Val Tyr Asn Ala Val Phe Val Glu Ser Ser 
            340                 345                 350         


Asp Lys Leu Asn Asn Tyr Pro Ala Tyr Ile Gly Met Thr Lys Lys Asn 
        355                 360                 365             


Gly Lys Lys Val Ser Leu Glu Gly Lys Arg Cys Ser Arg Glu Glu Phe 
    370                 375                 380                 


Met Asp Phe Leu Lys Lys Asn Ile Val Val Lys Leu Pro Asp Glu Glu 
385                 390                 395                 400 


Ala Lys Met Tyr Leu Gln Ser Glu Leu Glu Lys Asp Ser Phe Leu Pro 
                405                 410                 415     


Lys Gln Val Asn Lys Asp Asn Gly Val Ile Pro Tyr Gln Val His Lys 
            420                 425                 430         


Tyr Glu Leu Lys Lys Ile Leu Asp Asn Leu Gly Asp Lys Ile Pro Phe 
        435                 440                 445             


Leu Lys Glu Asn Ala Glu Lys Ile Glu Lys Leu Phe Ser Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Arg Thr Gly Asn Gly Glu Asn Ser Lys 
465                 470                 475                 480 


Phe Ala Trp Ala Glu Arg Lys Ser Thr Glu Lys Ile Tyr Pro Trp Asn 
                485                 490                 495     


Phe Glu Asn Val Ile Asp Val Glu Gln Ser Ala Glu Asn Phe Ile Arg 
            500                 505                 510         


Arg Met Thr Asn Lys Cys Thr Tyr Leu Ile Gly Glu Asp Val Leu Pro 
        515                 520                 525             


Lys Asp Ser Leu Leu Tyr Ser Lys Phe Met Val Leu Asn Glu Leu Asn 
    530                 535                 540                 


Asn Leu Arg Leu Asp Gly Gln Lys Ile Ser Val Glu Leu Lys Gln Lys 
545                 550                 555                 560 


Ile Tyr Arg Asp Val Phe Cys Arg Ser Arg Lys Val Thr Gln Lys Lys 
                565                 570                 575     


Leu Lys Ser Tyr Leu Ile Arg Glu Gly Ile Ala Gly Lys Asn Val Glu 
            580                 585                 590         


Leu Thr Gly Ile Asp Gly Asp Phe Lys Gly Ser Leu Thr Ala Tyr His 
        595                 600                 605             


Asp Phe Lys Glu Lys Leu Ile Asp Val Glu Leu Thr Gln Lys Glu Lys 
    610                 615                 620                 


Glu Glu Ile Ile Leu Asn Ile Val Leu Phe Gly Asp Asp Lys Lys Leu 
625                 630                 635                 640 


Leu Lys Gln Arg Leu Lys Lys Lys Phe Pro Gln Leu Thr Glu Lys Gln 
                645                 650                 655     


Ile Asn Thr Val Thr Ala Leu Ser Tyr Lys Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Lys Lys Leu Leu Glu Glu Val Thr Val Pro Ala Pro Glu Thr Gly Glu 
        675                 680                 685             


Val Trp Asn Ile Ile Thr Ala Leu Trp Glu Thr Asn Asp Asn Phe Met 
    690                 695                 700                 


Gln Leu Leu Ser Lys Glu Tyr Gln Phe Ser Asp Arg Ile Glu Glu Phe 
705                 710                 715                 720 


Asn Glu Glu Lys Ala Asp Pro Glu Val Ser Tyr Gln Thr Ile Glu Asp 
                725                 730                 735     


Leu Tyr Val Ser Pro Ala Val Lys Arg Gln Ile Trp Gln Thr Leu Gln 
            740                 745                 750         


Ile Ile Gln Glu Ile Glu Lys Val Met Gly Glu Lys Pro Lys Arg Val 
        755                 760                 765             


Phe Val Glu Met Ala Arg Glu Lys Gln Glu Asn Lys Arg Thr Glu Ser 
    770                 775                 780                 


Arg Lys Lys Thr Leu Ser Asp Leu Tyr Thr Lys Cys Lys Lys Glu Glu 
785                 790                 795                 800 


Pro Glu Trp Ile Glu Ala Leu Cys Thr Ser Leu Glu Lys His Glu Glu 
                805                 810                 815     


His Gln Leu Arg Ser Asp Lys Leu Tyr Leu Tyr Tyr Thr Gln Lys Gly 
            820                 825                 830         


Arg Cys Met Tyr Ser Gly Glu Pro Ile Asp Leu Glu Asp Leu Trp Asp 
        835                 840                 845             


Asn Thr Lys Tyr Asp Ile Asp His Ile Tyr Pro Gln Ser Lys Thr Met 
    850                 855                 860                 


Asp Asp Ser Leu Lys Asn Arg Val Leu Val Lys Lys Glu Tyr Asn Ala 
865                 870                 875                 880 


Lys Lys Ser Asp Thr Tyr Pro Ile Ala Ala Asp Ile Gln Lys Lys Met 
                885                 890                 895     


Met Pro Phe Trp Lys Ser Leu Leu Thr Gly Gly Phe Ile Pro Lys Glu 
            900                 905                 910         


Lys Tyr Asp Arg Leu Val Arg Asn Asn Pro Leu Asp Ala Asn Glu Leu 
        915                 920                 925             


Ala Gly Phe Ile Glu Arg Gln Ile Val Glu Thr Arg Gln Ser Thr Lys 
    930                 935                 940                 


Ala Val Ala Glu Ile Leu Lys Lys Ile Leu Pro Asp Thr Glu Ile Val 
945                 950                 955                 960 


Tyr Val Lys Ala Lys Thr Val Ser Lys Phe Arg Gln Asp Phe Asp Phe 
                965                 970                 975     


Ile Lys Val Arg Asp Met Asn Asp Leu His His Ala Lys Asp Ala Tyr 
            980                 985                 990         


Leu Asn Ile Val Val Gly Asn Val  Tyr Phe Val Lys Phe  Thr Lys Asn 
        995                 1000                 1005             


Ala Ala  Trp Phe Val Lys Glu  Asn Pro Gly Arg Thr  Tyr Asn Leu 
    1010                 1015                 1020             


Glu Lys  Met Phe Ile Trp Asp  Val Ala Arg Asp Gly  Glu Ile Ala 
    1025                 1030                 1035             


Trp Lys  Ala Gly Lys Ser Gly  Ser Ile Val Gln Val  Arg Ala Met 
    1040                 1045                 1050             


Met Glu  Lys Asn His Ile Leu  Val Thr Arg Arg Ser  Tyr Glu Val 
    1055                 1060                 1065             


Lys Gly  Gly Leu Phe Asp Gln  Gln Ile Leu Lys Lys  Gly Lys Gly 
    1070                 1075                 1080             


Gln Val  Pro Val Lys Glu Ser  Asp Glu Arg Leu Arg  Asp Ile Gly 
    1085                 1090                 1095             


Lys Tyr  Gly Gly Tyr Asn Lys  Ala Ala Gly Val Tyr  Phe Met Leu 
    1100                 1105                 1110             


Val Ser  Ser Lys Asp Lys Lys  Gly Lys Glu Gln Arg  Thr Ile Glu 
    1115                 1120                 1125             


Phe Val  Pro Ile Tyr Leu Lys  Asp Arg Val Glu Lys  Asp Met Glu 
    1130                 1135                 1140             


Ser Ala  Arg Asn Tyr Leu Met  Glu Glu Arg Gly Leu  Arg Glu Pro 
    1145                 1150                 1155             


Lys Ile  Leu Ile Lys Lys Ile  Lys Ile Asp Thr Leu  Phe Lys Val 
    1160                 1165                 1170             


Asp Gly  Phe Tyr Met Trp Leu  Ser Gly Arg Thr Ser  Asn Gln Leu 
    1175                 1180                 1185             


Ile Phe  Lys Gly Ala Asn Gln  Leu Ile Leu Ser Lys  Glu Asp Met 
    1190                 1195                 1200             


Lys Thr  Leu Lys Lys Val Val  Lys Tyr Ile Gln Arg  Gln Lys Glu 
    1205                 1210                 1215             


Asp Lys  Asn Val Lys Ile Ser  Met Arg Asp Gly Ile  Thr Glu Glu 
    1220                 1225                 1230             


Glu Leu  Leu Lys Leu Tyr Glu  Thr Phe Leu Asp Lys  Ile Arg His 
    1235                 1240                 1245             


Ser Ile  Tyr Gly Ala Arg Leu  Ser Ser Gln Glu Lys  Thr Leu Val 
    1250                 1255                 1260             


Asn Gly  Lys Glu Lys Phe Ile  Asp Leu Ser Val Glu  Ala Lys Cys 
    1265                 1270                 1275             


Gln Val  Leu Tyr Glu Ile Leu  His Leu Phe Gln Cys  Gln Ser Gly 
    1280                 1285                 1290             


Ala Ala  Asn Leu Lys Met Ile  Gly Gly Pro Ala Ser  Ala Gly Ile 
    1295                 1300                 1305             


Leu Val  Met Asn Asn Asn Ile  Ser Lys Cys Lys Asn  Ile Ser Ile 
    1310                 1315                 1320             


Val Asn  Gln Ser Pro Thr Gly  Ile Tyr Glu Lys Glu  Ile Asp Leu 
    1325                 1330                 1335             


Leu Arg  Val 
    1340     


<210> 418
<211> 1471
<212> PRT
<213> Scardovia wiggsiae


<220>
<223> Scardovia wiggsiae F0424

<400> 418
Met Gly Tyr Lys Ala Pro Arg Asn Asp Lys Gly Glu Ile Asp Tyr Gly 
1               5                   10                  15      


Val Gly Leu Asp Leu Gly Asn Gly Ser Val Gly Trp Val Ala Met Asp 
            20                  25                  30          


Lys Asp Tyr His Leu Ile Arg Ala Arg Gly His Glu Leu Ile Gly Ala 
        35                  40                  45              


Arg Leu Phe Asp Pro Ala Asn Ser Ala Glu Asn Arg Arg Glu Ser Arg 
    50                  55                  60                  


Thr Thr Arg Arg Arg Leu Ser Arg Arg Arg Trp Arg Leu Arg Met Leu 
65                  70                  75                  80  


Asp Ser Leu Phe Ala Ser Glu Leu Ala Lys Ile Asp Pro Asn Phe Leu 
                85                  90                  95      


Ala Arg Arg Lys Tyr Ser Trp Val His Pro Lys Asp Glu Gln Asn His 
            100                 105                 110         


Glu Asn Trp Tyr Gly Ser Ile Ile Phe Gly Ser Lys Glu Gln Asp Lys 
        115                 120                 125             


Gln Phe Tyr Lys Asp Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu 
    130                 135                 140                 


Thr Glu Asp Thr Glu Arg His Asp Ile Arg Glu Ile Tyr Val Ala Ile 
145                 150                 155                 160 


His His Ile Val Lys Tyr Arg Gly His Phe Leu Arg Glu Gly Glu Ile 
                165                 170                 175     


Asn Ser Glu Asn Leu Phe Asp Pro Glu Gly Phe Val Glu Leu Ile Lys 
            180                 185                 190         


Asp Val Ile Lys Leu Asn Asn Ser Tyr Asp Glu Ser Thr Pro Ile Phe 
        195                 200                 205             


Glu Ala Ser Pro Ala Asp Val Ser Glu Ala Leu Leu Asn Glu His Thr 
    210                 215                 220                 


Ser Arg Ser Gly Arg Ile Glu Asp Thr Leu Asp Lys Leu Asp Phe Ser 
225                 230                 235                 240 


Val Ser Arg Val Asp Lys His Glu Leu Lys Gly Met Arg Asp Ala Ala 
                245                 250                 255     


Lys Ala Val Ile Gly Ala Ile Val Gly Asn Thr Ala Asp Phe Ser Lys 
            260                 265                 270         


Ile Phe Asn Leu Asp Asn Leu Asp Lys Asp Ser Lys Asp Asn Leu Lys 
        275                 280                 285             


Leu Lys Phe Ala Asp Ser Asn Phe Asp Glu Lys Tyr Gly Gly Val Val 
    290                 295                 300                 


Gly Ser Gly Leu Leu Asp Glu Thr Gln Ile Glu Leu Val Asp Arg Ile 
305                 310                 315                 320 


His Ala Val Tyr Asp Ala Val Ala Leu Lys Gly Ile Leu Gly Asp Ala 
                325                 330                 335     


His Thr Ile Ser Glu Ala Lys Val Glu Ser Tyr Glu Lys His Arg Lys 
            340                 345                 350         


Asn Trp Lys Leu Ile Lys Glu Glu Leu Arg Thr Lys Glu Asn Lys Asp 
        355                 360                 365             


Glu Val Asp Leu Trp Tyr Gly Asp Leu Ser Gly Arg Gln Tyr Lys Asn 
    370                 375                 380                 


Pro Pro Asp Pro Glu Lys Gly Pro Asp Glu Gly Ser Lys Lys Asp Ser 
385                 390                 395                 400 


Pro Ile Arg Asp Ser Asp Gln Lys Gln Asn Leu Ile Lys Lys Ala Asn 
                405                 410                 415     


Asp Tyr Phe Thr Glu Leu Ile Asp Asp Ser Gln Leu Ser Glu Glu Gln 
            420                 425                 430         


Lys Asn Cys Leu Lys Asn Asp Ile Asn Asn Gly Gln Leu Phe Pro Val 
        435                 440                 445             


Gln Arg Ser Ser Asp Asn Gly Val Ile Pro Tyr Gln Ile His Leu Asn 
    450                 455                 460                 


Glu Leu Arg Arg Ile Ile Glu Asn Gln Lys Gln Tyr Tyr Pro Phe Leu 
465                 470                 475                 480 


Ala Glu Thr Phe Ile Arg Lys Thr Ala Glu Gly Lys Ser Tyr Glu Glu 
                485                 490                 495     


Asn Lys Ile Val Ala Leu Leu Lys Phe Arg Val Pro Tyr Tyr Val Gly 
            500                 505                 510         


Pro Leu Val Ser Lys Glu Asp Met Glu Glu His Ser Ser Gly Asn Ser 
        515                 520                 525             


Ala Tyr His Trp Met Ala Arg Asn Pro Gly Arg Gly Glu Ala Ile Thr 
    530                 535                 540                 


Pro Trp Asn Phe Asp Glu Val Val Asp Lys Asp Glu Ser Gly Ala Arg 
545                 550                 555                 560 


Phe Ile Ser Arg Leu Thr Gly Thr Asp Thr Tyr Leu Leu Gly Glu Pro 
                565                 570                 575     


Thr Leu Pro Gln His Ser Leu Leu Tyr Glu Glu Tyr Met Val Leu Ser 
            580                 585                 590         


Glu Leu Asn Asn Val Arg Leu Asn Val Arg Gln Gly Asn His Trp Ser 
        595                 600                 605             


Asp Lys Asn Arg Gln Arg Leu Ser Tyr Lys Gln Lys Glu Phe Leu Ile 
    610                 615                 620                 


Glu Asn Leu Phe Lys Glu His Lys Thr Val Thr Arg Lys Arg Ala Glu 
625                 630                 635                 640 


Asp Cys Leu Ser Ser Met Gly Cys Gly Glu Val Gln Leu Phe Gly Leu 
                645                 650                 655     


Ser Asp Glu Lys Lys Phe Ala Ser Ser Leu Ser Ser Tyr Ile Thr Leu 
            660                 665                 670         


Lys Lys Ile Leu Gly Lys Ala Phe Val Asp Asp Ser Gly Asn Ser Ala 
        675                 680                 685             


Ile Leu Glu Arg Ile Ile Glu Val Gln Thr Val Phe Glu Asp Arg Glu 
    690                 695                 700                 


Pro Leu Thr His Gln Leu Ser Leu Ile Asp Ser Leu Thr Val Glu Gln 
705                 710                 715                 720 


Arg Lys Gln Leu Ala Lys Ile His Tyr Thr Gly Trp Gly Lys Leu Ser 
                725                 730                 735     


Arg Lys Leu Leu Thr Ser Lys Lys Gly Ser Tyr Lys Ile His Ser Gln 
            740                 745                 750         


Asn Glu Ile Met Arg Thr Gln His Ser Ile Ile Asp Ile Met Arg Gly 
        755                 760                 765             


Asp Ser Leu Asn Leu Ile Glu Ile Ile Arg Asp Lys Lys Ile Gly Ile 
    770                 775                 780                 


Gly Glu Trp Ile Asp Asn Glu Asn Leu Asp Arg Glu Thr Gly Glu Ser 
785                 790                 795                 800 


Asp Val Ser Arg Leu Glu Ser Val Phe Glu Gly Ile Val Met Ser Pro 
                805                 810                 815     


Arg Val Lys Arg Gly Val Val Gln Ala Val Arg Val Ile Asp Asp Leu 
            820                 825                 830         


Ala Lys Ala Ile Gly Asn Pro Pro Gln Arg Ile Phe Ile Glu Met Ala 
        835                 840                 845             


Asp Glu Val Gln Ala Ser Gln Arg Thr Val Ser Arg Leu Ser Arg Leu 
    850                 855                 860                 


Lys Ala Leu Tyr Gly Ser Pro Ser Leu Gln Lys Glu Phe Asn Asp Leu 
865                 870                 875                 880 


Lys Asp Leu Arg Lys Ser Leu Asn Glu Thr Lys Asp Ala Asp Leu Gln 
                885                 890                 895     


Glu Asp Arg Leu Tyr Leu Tyr Tyr Ile Gln Leu Gly Lys Asp Leu Tyr 
            900                 905                 910         


Thr Gly Lys Glu Ile Ser Ile Asp Ser Leu Ser Ser Ala Tyr Asp Ile 
        915                 920                 925             


Asp His Ile Val Pro Gln Ala Leu Thr Gln Asp Asp Ser Ile Asp Asn 
    930                 935                 940                 


Arg Val Leu Val Ser Arg Lys Glu Asn Ala Arg Lys Thr Asp Ser Tyr 
945                 950                 955                 960 


Leu Tyr Thr Pro Asp Leu Ile Lys Asn Met Arg Pro Leu Trp Gly Lys 
                965                 970                 975     


Leu Leu Ala Ala Gly Leu Met Ser Gln Lys Lys Tyr Asp Ala Leu Thr 
            980                 985                 990         


Arg Val Asp Asp Phe Lys Asp Arg  Glu Lys Gln Arg Phe  Val Gln Arg 
        995                 1000                 1005             


Ser Leu  Val Glu Thr Arg Gln  Ile Met Lys Asn Val  Ser Thr Ile 
    1010                 1015                 1020             


Leu Arg  Thr Tyr Tyr Gly Glu  Asp Thr Asn Val Val  Thr Leu Lys 
    1025                 1030                 1035             


Ser Ser  Ile Thr His Asp Met  Arg Lys Tyr Leu Gly  Phe Pro Tyr 
    1040                 1045                 1050             


Lys Asn  Arg Asp Ile Asn Asp  Tyr His His Ala Gln  Asp Ala Leu 
    1055                 1060                 1065             


Cys Ile  Ser Ala Ala Gly Gln  Phe Met Leu Asn Arg  His Phe Val 
    1070                 1075                 1080             


Ser Gly  Gly Glu Val Thr Asp  Gly Ala Ser Asn Ala  Tyr Asn Met 
    1085                 1090                 1095             


Tyr Leu  Ala Glu Tyr Leu Gln  Glu Phe Arg Asp Ala  Lys Ala Arg 
    1100                 1105                 1110             


Gly Glu  Arg Lys Arg Ser Thr  Ala Phe Gly Phe Val  Val Gly Ser 
    1115                 1120                 1125             


Met Ser  Ser Lys Asp Asp Glu  Lys Arg Thr Asp His  Arg Thr Gly 
    1130                 1135                 1140             


Glu Ile  Val Trp Ser Glu Thr  Asn Ala Glu Tyr Leu  Arg Lys Val 
    1145                 1150                 1155             


Met Asn  Tyr Lys Lys Met Leu  Ile Thr Gln Lys Val  Gly Asp Val 
    1160                 1165                 1170             


Lys Thr  Arg Ala Leu Tyr Asp  Glu Thr Arg Tyr Gly  His Lys Glu 
    1175                 1180                 1185             


Ser Ser  Ala Lys Ser Ile Lys  Phe Asp Asn Leu Arg  Arg Asp Thr 
    1190                 1195                 1200             


Ser Leu  Tyr Gly Gly Phe Ser  Gly Ala Ser Thr Ala  Tyr Met Met 
    1205                 1210                 1215             


Leu Val  Glu Tyr Lys Lys Lys  Asn Lys Leu Val Ser  Ile Thr Ala 
    1220                 1225                 1230             


Gln Glu  Ala Ser Leu Leu Ala  Val Ala Asp Gln Lys  Asn Asp Thr 
    1235                 1240                 1245             


Val Ser  Val Met Asp Gly Ile  Leu Ala Ser His Gly  Leu Ser Gly 
    1250                 1255                 1260             


Ala Lys  Ile Leu Leu Pro Lys  Ile Val Thr Gly Gln  Leu Leu Asp 
    1265                 1270                 1275             


Tyr Ser  Asp Ala Leu Val Thr  Leu Gln Ser Ala Ser  Glu Leu Asn 
    1280                 1285                 1290             


Thr Ala  Arg Gln Met Trp Leu  Pro Arg Asn Asp Tyr  Asn Asp Ile 
    1295                 1300                 1305             


Asp Ile  Ile Leu Lys Ser Lys  Asp Ile Glu Asp Ala  Ala His Lys 
    1310                 1315                 1320             


Leu Gly  Tyr Asp Ser Asp Thr  Val His Val Leu Arg  Arg Ile Gln 
    1325                 1330                 1335             


Lys Leu  Phe Glu Ala Val Phe  Arg Val Ala Glu Ser  Gln Phe Pro 
    1340                 1345                 1350             


Leu His  Gln Leu Ser Lys Asp  Gln Gln Glu Glu Ile  Leu Arg Asp 
    1355                 1360                 1365             


Pro Gln  Asn Tyr Gly Phe Gly  Ser Ala Val Lys Leu  Leu Gly Gly 
    1370                 1375                 1380             


Leu Leu  Lys Ala Leu His Ala  Asn Ala Glu Asn Thr  Asn Leu Ala 
    1385                 1390                 1395             


Gly Leu  Val Lys Val Leu His  Gly Asp Lys Glu Tyr  Ser Asp Asp 
    1400                 1405                 1410             


Gly Lys  Ala Lys Glu Phe Lys  Lys Phe Gly Phe Ser  Pro Arg Trp 
    1415                 1420                 1425             


Arg Arg  Ile Ser Asn Pro Thr  Gly Phe Thr Leu Ser  Asp Ser Asp 
    1430                 1435                 1440             


Thr Phe  Ile Tyr Gln Ser Pro  Ser Gly Ile Phe Glu  Gln Arg Val 
    1445                 1450                 1455             


Thr Val  Lys Glu Leu Lys Glu  Lys Ala Asp Lys Gln  Lys 
    1460                 1465                 1470     


<210> 419
<211> 1178
<212> PRT
<213> Scardovia inopinata


<220>
<223> Scardovia inopinata F0304

<400> 419
Met Gly Lys Arg His Asn Ser Asn Met Ala Lys Lys Lys Ile Ser Tyr 
1               5                   10                  15      


Arg Ile Gly Ile Asp Val Gly Leu Asn Ser Thr Gly Leu Ala Ala Ile 
            20                  25                  30          


Glu Val Asp Asp Asp Gly Ala Pro Ile Arg Ile Leu Asn Thr Met Ser 
        35                  40                  45              


Val Ile His Asp Gly Gly Val Asp Pro Asp Ala Ala Lys Val Arg Gly 
    50                  55                  60                  


Thr Arg Leu Ala Ile Ser Gly Ile Ala Arg Arg Thr Arg Arg Met Arg 
65                  70                  75                  80  


Arg Arg Arg Ala Lys Arg Leu Asp Arg Leu Glu Gln Ile Leu Glu Lys 
                85                  90                  95      


Tyr Gly Tyr Thr Asp Thr Glu Pro Val Leu Glu Glu Pro Tyr Gly Pro 
            100                 105                 110         


Trp Ile Cys Arg Ala Glu Leu Ala Asp Gly Phe Ile Asn Asp Asp Glu 
        115                 120                 125             


Gln Arg Arg Met Met Ile Gly Ile Ala Ile Arg His Ile Ala Arg His 
    130                 135                 140                 


Arg Gly Trp Arg Asn Pro Tyr Gln Asn Val Arg Ala Leu Leu Asn Ile 
145                 150                 155                 160 


Asp Asp Ser Asp Leu Ser Glu Glu Tyr Lys Asn Leu Lys Glu Lys Val 
                165                 170                 175     


Gln Asp Gln Ile Asn Asp Gly Lys Asp Leu Pro Asn Phe Thr Pro Ser 
            180                 185                 190         


Gln Leu Val Arg Asp Tyr Leu Asp Asn Phe Ser Gly Gln Pro Ala Ala 
        195                 200                 205             


Arg Ile Arg Thr Gly Lys Ala Gly Pro Arg Gly Asn Arg Arg Asp Ala 
    210                 215                 220                 


Val Gly Ile Leu Pro Gln Arg Met Arg Gln Ser Asp Tyr Ala Tyr Glu 
225                 230                 235                 240 


Leu Gln Arg Ile Phe Asp Met Gln Lys Ile Gly Arg Asp Glu Ala Gln 
                245                 250                 255     


Glu Leu Leu Met Ala Val Phe Glu Ala Lys Ser Pro Lys Gly Ser Ala 
            260                 265                 270         


Glu Lys Arg Ile Gly Lys Asp Pro Leu Thr Gly Lys Lys Arg Ala Leu 
        275                 280                 285             


Lys Ala Ser Leu Ala Phe Gln Lys Tyr Arg Ile Val Ala Thr Ile Thr 
    290                 295                 300                 


Asn Leu Arg Ile Lys Thr Gly Thr Gly Ser Glu Arg Met Leu Ser Pro 
305                 310                 315                 320 


Thr Glu Leu Asn Asp Ile Tyr Thr Tyr Leu Leu Arg Val Gln Asp Asp 
                325                 330                 335     


Asn His Leu Pro Thr Trp Glu Asp Ile Cys Glu Glu Val Leu His Ile 
            340                 345                 350         


Gly Arg Tyr Gln Leu Ala Gly Ile Gly Lys Thr Phe Glu Gly Gly Glu 
        355                 360                 365             


Arg Ile Ser Asn Met Pro Pro Val Ile Gln Thr Ser Leu Ala Ile His 
    370                 375                 380                 


Gly Leu Ser Glu Gly Thr Leu Ala Glu Lys Leu Thr Lys Trp Trp Asp 
385                 390                 395                 400 


Lys Ala Asp Asp Asp Ser Arg Glu Ser Met Ile Lys Leu Leu Ser Asn 
                405                 410                 415     


Thr Val Asp Ile Asp Arg Val Asn Glu Val Asp Glu Asn Phe Ala Ser 
            420                 425                 430         


Ala Leu Asp Phe Ile Asp Ser Leu Asp Asp Glu Glu Leu Thr Lys Leu 
        435                 440                 445             


Asp Lys Ile Ala Leu Pro Arg Gly Arg Ala Ala Tyr Ser Glu Glu Ala 
    450                 455                 460                 


Leu Asn Lys Leu Thr Ala Asp Met Leu Asn Thr Gly Asp Asp Leu Phe 
465                 470                 475                 480 


Ser Ala Arg Gln Arg Ile Tyr His Val Asn Asn Ser Trp Arg Pro Pro 
                485                 490                 495     


Gln Pro Pro Ile Gly Glu Pro Leu Gly Asn Pro Ala Val Asp Arg Val 
            500                 505                 510         


Leu Lys Ile Thr Asn Arg Tyr Leu Met Asn Cys Leu Asn Arg Trp Gly 
        515                 520                 525             


Gln Pro Arg Arg Val Thr Ile Glu His Thr Arg Ser Gly Phe Thr Ser 
    530                 535                 540                 


Val Lys Gln Ala Thr Glu His Gln Lys Ile Ser Asp Lys Arg Ala Glu 
545                 550                 555                 560 


Tyr Arg Arg Asp Ile Val Lys Gln Leu Glu Glu Ala Gly Val Glu Ser 
                565                 570                 575     


Val His Glu Tyr Asp Ile Arg Arg Trp Glu Ala Val Gln Arg Gln Asn 
            580                 585                 590         


Gly Gln Cys Leu Tyr Cys Gly Arg Asp Ile Thr Phe Lys Thr Cys Glu 
        595                 600                 605             


Met Asp His Ile Val Pro Arg Lys Gly Pro Gly Ser Thr Asn Thr Arg 
    610                 615                 620                 


Thr Asn Phe Ala Ala Val Cys Pro Glu Cys Asn Arg Met Lys Ser Asn 
625                 630                 635                 640 


Ile Pro Phe Ala Ser Trp Ala Glu Thr Lys Glu Ala Lys Asp Arg Gly 
                645                 650                 655     


Val Ser Leu Asp Lys Ala Ile Lys Gln Val Arg Phe Phe Asn Phe Thr 
            660                 665                 670         


Lys Asn Glu Tyr Ser Pro Gln Ala Gln Arg Asn Phe Lys Lys Ser Met 
        675                 680                 685             


Ile Glu Arg Leu Lys Gln Lys Thr Ser Asp Glu Pro Leu Asp Asn Arg 
    690                 695                 700                 


Ser Ile Glu Ser Val Ser Trp Met Ala Asp Glu Leu Tyr Lys Arg Ile 
705                 710                 715                 720 


Asp Trp Tyr Phe Asn His Glu Gln Tyr Glu Thr Ser Lys Lys Ala Ile 
                725                 730                 735     


Asn Asp Asp Lys Asp Asn Leu Ser Gly Thr Gln Val Val Val Tyr Pro 
            740                 745                 750         


Gly Ser Ile Thr Ala Glu Ala Arg Asn Ala Ala Gly Leu Gly Gly Asn 
        755                 760                 765             


Ile His Phe Ile Gly Gly Arg Tyr Lys Thr Arg Leu Asp Arg Arg His 
    770                 775                 780                 


His Ala Val Asp Ala Cys Val Ile Ala Met Met Glu Pro Gly Ile Ala 
785                 790                 795                 800 


Arg Ile Leu Thr Glu Arg Asn Gln Leu Arg Gln Ala Gln Arg Leu Thr 
                805                 810                 815     


Ala Arg Ile Glu Asp Asp Glu Val Asn Trp Lys Asp Tyr Pro Thr Glu 
            820                 825                 830         


Asn Thr Ala Gly Tyr Asn Lys Tyr Gln Ala Trp Ser Asp Arg Met His 
        835                 840                 845             


Ala Leu Leu Glu Tyr Met Asn Asn Ala Leu Asp Tyr Asp Lys Ile Pro 
    850                 855                 860                 


Val Val Arg Trp Glu Arg Leu Gln Leu Gly Asn Arg Ser Ala His Glu 
865                 870                 875                 880 


Asp Thr Ile His Pro Leu Lys Lys Leu Pro Leu Ser His Glu Ile Ser 
                885                 890                 895     


Ala Ile Asp Ile Asn His Ala Ser Thr Pro Ala Leu Tyr Glu Ala Leu 
            900                 905                 910         


Val Ser Leu Pro Asp Phe Ser Glu Gln Asp Gly Leu Pro Ala Asp Pro 
        915                 920                 925             


Ser Arg Gln Ile Asn Val Asn Gly Glu Arg Tyr Ser Gly Asp Asp Leu 
    930                 935                 940                 


Val Ser Phe Phe Asn Ser Asn Ala Ala Gln Ile Ala Ile Gln Gly Gly 
945                 950                 955                 960 


Ser Ala Glu Leu Gly Thr Ala Phe His His Ala Arg Ile Tyr Arg Cys 
                965                 970                 975     


Trp Thr Val Gly Lys Asn Gly Lys Lys Lys Ile Phe Phe Gly Met Ile 
            980                 985                 990         


Arg Val Tyr Gln His Asp Leu Leu  His Ala Lys Asn Glu  Asp Leu Phe 
        995                 1000                 1005             


Thr Tyr  Pro Leu Lys Arg Ser  Ser Val Ser Met Arg  Tyr Ala Lys 
    1010                 1015                 1020             


Lys Glu  Val Val His Ala Ile  Leu Ser Gly Asn Ala  Glu Tyr Val 
    1025                 1030                 1035             


Gly Tyr  Leu Cys Val Gly Asp  Glu Leu Val Leu Asp  Leu Lys Gly 
    1040                 1045                 1050             


Asp Lys  Ser Asn Asp Glu Gly  Gly Ser Arg Leu Ser  Gly Gln Val 
    1055                 1060                 1065             


Gly Glu  Phe Val Gln Lys Phe  Glu Glu Asp Ser Lys  Val Asn Ser 
    1070                 1075                 1080             


Gln Ile  Val Asn Arg Trp Thr  Val Asp Gly Phe Pro  Asp Glu Ala 
    1085                 1090                 1095             


Lys Leu  Arg Leu Arg Pro Ser  Met Phe Ala Gly Glu  Gly Leu Lys 
    1100                 1105                 1110             


Asn Met  Lys Ser Glu Leu Val  Glu Asn Ala Ala Ile  Lys Asn Ile 
    1115                 1120                 1125             


Leu Ser  Lys Thr Gly Trp Arg  Val Ser Val Asp Val  Ile Ser Lys 
    1130                 1135                 1140             


Lys Ser  Pro Val Val Leu Arg  Arg Asn Ala Phe Gly  Glu Pro Arg 
    1145                 1150                 1155             


Trp Lys  Thr Asn Ala Gly Leu  Pro Val Ser Tyr Arg  Trp Gln Asp 
    1160                 1165                 1170             


Thr Glu  Thr Lys Glu 
    1175             


<210> 420
<211> 1063
<212> PRT
<213> Simonsiella muelleri


<220>
<223> Simonsiella muelleri ATCC 29453

<400> 420
Met Glu Lys Phe His Tyr Val Leu Gly Leu Asp Leu Gly Ile Ala Ser 
1               5                   10                  15      


Val Gly Trp Ala Ala Ile Glu Ile Asp Lys Glu Thr Glu Thr Ser Ile 
            20                  25                  30          


Gly Leu Leu Asp Cys Gly Val Arg Thr Phe Glu Arg Ala Glu Val Pro 
        35                  40                  45              


Lys Thr Gly Asp Ser Leu Ala Lys Ala Arg Arg Glu Ala Arg Ser Thr 
    50                  55                  60                  


Arg Arg Leu Ile Arg Arg Arg Ser His Arg Leu Leu Arg Leu Lys Arg 
65                  70                  75                  80  


Leu Leu Lys Arg Glu Ile Phe Arg Gln Pro Glu Thr Phe Lys Asp Leu 
                85                  90                  95      


Pro Ile Asn Ala Trp Gln Leu Arg Val Lys Gly Leu Asp Ser Arg Leu 
            100                 105                 110         


Asn Glu Tyr Glu Trp Ala Ala Val Leu Leu His Leu Val Lys His Arg 
        115                 120                 125             


Gly Tyr Leu Ser Gln Arg Lys Ser Glu Met Ser Glu Thr Asp Ser Lys 
    130                 135                 140                 


Ser Glu Met Gly Arg Leu Leu Ala Gly Val Ala Glu Asn His Gln Leu 
145                 150                 155                 160 


Leu Gln Gln Glu Gln Tyr Arg Thr Pro Ala Glu Leu Ala Leu Lys Lys 
                165                 170                 175     


Phe Val Lys His Phe Arg Asn Lys Gly Gly Asp Tyr Ala His Thr Phe 
            180                 185                 190         


Asn Arg Leu Asp Leu Gln Ala Glu Leu His Leu Leu Phe Gln Lys Gln 
        195                 200                 205             


Arg Glu Leu Gly Asn Pro Phe Thr Ser Pro Glu Leu Glu Arg Gln Val 
    210                 215                 220                 


Asp Asp Leu Leu Met Thr Gln Arg Ser Ala Leu Gln Gly Asp Ala Ile 
225                 230                 235                 240 


Leu Lys Met Leu Gly His Cys Gly Phe Glu Pro Glu Gln Phe Lys Ala 
                245                 250                 255     


Ala Lys Asn Thr Phe Ser Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu 
            260                 265                 270         


Asn Asn Leu Arg Ile Gln Asp Gln Gly Lys Glu Arg Ala Leu Thr Ala 
        275                 280                 285             


Asp Glu Arg Thr Lys Leu Leu Asp Glu Pro Tyr Lys Lys Ser Lys Leu 
    290                 295                 300                 


Thr Tyr Ala Gln Val Arg Lys Leu Leu Ser Leu Pro Gln Thr Ala Ile 
305                 310                 315                 320 


Phe Lys Gly Leu Arg Tyr Asp Leu Glu His Asp Lys Lys Ala Glu Asn 
                325                 330                 335     


Ser Thr Leu Met Glu Met Lys Ser Tyr His Asn Ile Arg Gln Thr Leu 
            340                 345                 350         


Glu Lys Ser Gly Leu Lys Thr Glu Trp Gln Ser Ile Ala Thr Gln Pro 
        355                 360                 365             


Glu Ile Leu Asp Ala Ile Gly Thr Ala Phe Ser Ile Tyr Lys Thr Asp 
    370                 375                 380                 


Glu Asp Ile Ser His Glu Leu Lys Thr Cys Arg Leu Pro Glu Asn Val 
385                 390                 395                 400 


Leu Asn Glu Leu Leu Lys Asn Ile Asn Phe Asp Gly Phe Ile Gln Leu 
                405                 410                 415     


Ser Leu Thr Ala Leu Arg Lys Ile Leu Pro Leu Met Glu Gln Gly Tyr 
            420                 425                 430         


Arg Tyr Asp Glu Ala Cys Thr Gln Ile Tyr Gly Asn His His Ser Gly 
        435                 440                 445             


Ser Leu Gln Gln Glu Ser Lys Gln Phe Leu Pro His Ile Pro Ile Asp 
    450                 455                 460                 


Asp Val Arg Asn Pro Val Val Phe Arg Thr Leu Thr Gln Ala Arg Lys 
465                 470                 475                 480 


Val Val Asn Ala Ile Ile Arg Arg Tyr Gly Ser Pro Ala Arg Val His 
                485                 490                 495     


Ile Glu Met Ala Arg Glu Leu Gly Lys Ser Lys Ser Asp Arg Asp Arg 
            500                 505                 510         


Ile Glu Lys Gln Gln Gln Lys Asn Lys Lys Glu Arg Glu Asn Ala Val 
        515                 520                 525             


Ala Lys Phe Lys Glu Asp Phe Pro Asp Phe Val Gly Glu Pro Arg Gly 
    530                 535                 540                 


Lys Asp Ile Leu Lys Met Arg Leu Tyr Glu Gln Gln His Gly Lys Cys 
545                 550                 555                 560 


Leu Tyr Ser Gly His Asp Ile Asp Ile Asn Arg Leu Asn Glu Lys Gly 
                565                 570                 575     


Tyr Val Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp 
            580                 585                 590         


Ser Gln Asn Asn Lys Val Leu Val Leu Gly Ser Glu Asn Gln Asn Lys 
        595                 600                 605             


Arg Asn Gln Thr Pro Asp Glu Tyr Leu Asp Gly Ala Asn Asn Ser Gln 
    610                 615                 620                 


Arg Trp Leu Glu Phe Gln Ala Arg Val Gln Thr Cys His Phe Ser Tyr 
625                 630                 635                 640 


Gly Lys Lys Gln Arg Ile Gln Leu Ala Lys Leu Asp Asp Glu Thr Glu 
                645                 650                 655     


Lys Gly Phe Leu Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Arg 
            660                 665                 670         


Phe Met Cys Gln Phe Val Gln Glu Asn Leu Tyr Leu Thr Gly Lys Gly 
        675                 680                 685             


Lys Arg Leu Val Phe Ala Ser Asn Gly Gly Met Thr Ala Thr Leu Arg 
    690                 695                 700                 


Asn Leu Trp Gly Leu Arg Lys Val Arg Glu Asp Asn Asp Arg His His 
705                 710                 715                 720 


Ala Leu Asp Ala Ile Val Val Ala Cys Ser Thr Ala Ser Met Gln Gln 
                725                 730                 735     


Lys Ile Thr Lys Ala Phe Gln Arg His Glu Ser Ile Glu Tyr Val Asp 
            740                 745                 750         


Thr Glu Thr Gly Glu Val Lys Phe Arg Ile Pro Gln Pro Trp Asp Phe 
        755                 760                 765             


Phe Arg Gln Glu Val Met Ile Arg Val Phe Ser Asp Gln Pro Cys Glu 
    770                 775                 780                 


Asp Leu Val Glu Lys Leu Ser Ala Arg Pro Glu Ala Leu His Asp Asn 
785                 790                 795                 800 


Val Thr Pro Leu Phe Val Ser Arg Ala Pro Asn Arg Lys Met Ser Gly 
                805                 810                 815     


Gln Gly His Leu Glu Thr Ile Lys Ser Ala Lys Arg Leu Ser Glu Glu 
            820                 825                 830         


Asn Ser Met Val Lys Lys Pro Leu Thr Thr Leu Lys Leu Lys Asp Ile 
        835                 840                 845             


Pro Glu Ile Val Gly Tyr Pro Ser Arg Glu Pro Gln Leu Tyr Ala Ala 
    850                 855                 860                 


Leu Lys Thr Arg Leu Glu Thr His Asp Asp Asp Pro Ile Lys Ala Phe 
865                 870                 875                 880 


Ala Lys Pro Phe Tyr Lys Pro Asn Lys Asn Gly Glu Leu Gly Ala Leu 
                885                 890                 895     


Val Arg Ser Val Arg Val Lys Gly Val Gln Asn Thr Gly Val Met Val 
            900                 905                 910         


His Asp Gly Lys Gly Ile Ala Asp Asn Ala Thr Met Val Arg Val Asp 
        915                 920                 925             


Val Tyr Thr Lys Ala Gly Lys Asn Tyr Leu Val Pro Val Tyr Val Trp 
    930                 935                 940                 


Gln Val Ala Gln Gly Ile Leu Pro Asn Arg Ala Val Thr Ser Gly Lys 
945                 950                 955                 960 


Ser Glu Ala Asp Trp Asp Leu Ile Asp Glu Ser Phe Glu Phe Lys Phe 
                965                 970                 975     


Ser Leu Ser Arg Gly Asp Leu Val Glu Met Ile Ser Asn Lys Gly Arg 
            980                 985                 990         


Ile Phe Gly Tyr Tyr Asn Gly Leu  Asp Arg Ala Asn Gly  Ser Ile Gly 
        995                 1000                 1005             


Ile Arg  Glu His Asp Leu Glu  Lys Ser Lys Gly Lys  Asp Gly Val 
    1010                 1015                 1020             


His Arg  Val Gly Val Lys Thr  Ala Thr Ala Phe Asn  Lys Tyr His 
    1025                 1030                 1035             


Val Asp  Pro Leu Gly Lys Glu  Ile His Arg Cys Ser  Ser Glu Pro 
    1040                 1045                 1050             


Arg Pro  Thr Leu Lys Ile Lys  Ser Lys Lys 
    1055                 1060             


<210> 421
<211> 1327
<212> PRT
<213> Solobacterium moorei


<220>
<223> Solobacterium moorei F0204

<400> 421
Met Glu Gly Gln Met Lys Asn Asn Gly Asn Asn Leu Gln Gln Gly Asn 
1               5                   10                  15      


Tyr Tyr Leu Gly Leu Asp Val Gly Thr Ser Ser Val Gly Trp Ala Val 
            20                  25                  30          


Thr Asp Thr Asp Tyr Asn Val Leu Lys Phe Arg Gly Lys Ser Met Trp 
        35                  40                  45              


Gly Ala Arg Leu Phe Asp Glu Ala Ser Thr Ala Glu Glu Arg Arg Thr 
    50                  55                  60                  


His Arg Gly Asn Arg Arg Arg Leu Ala Arg Arg Lys Tyr Arg Leu Leu 
65                  70                  75                  80  


Leu Leu Glu Gln Leu Phe Glu Lys Glu Ile Arg Lys Ile Asp Asp Asn 
                85                  90                  95      


Phe Phe Val Arg Leu His Glu Ser Asn Leu Trp Ala Asp Asp Lys Ser 
            100                 105                 110         


Lys Pro Ser Lys Phe Leu Leu Phe Asn Asp Thr Asn Phe Thr Asp Lys 
        115                 120                 125             


Asp Tyr Leu Lys Lys Tyr Pro Thr Ile Tyr His Leu Arg Ser Asp Leu 
    130                 135                 140                 


Ile His Asn Ser Thr Glu His Asp Ile Arg Leu Val Phe Leu Ala Leu 
145                 150                 155                 160 


His His Leu Ile Lys Tyr Arg Gly His Phe Ile Tyr Asp Asn Ser Ala 
                165                 170                 175     


Asn Gly Asp Val Lys Thr Leu Asp Glu Ala Val Ser Asp Phe Glu Glu 
            180                 185                 190         


Tyr Leu Asn Glu Asn Asp Ile Glu Phe Asn Ile Glu Asn Lys Lys Glu 
        195                 200                 205             


Phe Ile Asn Val Leu Ser Asp Lys His Leu Thr Lys Lys Glu Lys Lys 
    210                 215                 220                 


Ile Ser Leu Lys Lys Leu Tyr Gly Asp Ile Thr Asp Ser Glu Asn Ile 
225                 230                 235                 240 


Asn Ile Ser Val Leu Ile Glu Met Leu Ser Gly Ser Ser Ile Ser Leu 
                245                 250                 255     


Ser Asn Leu Phe Lys Asp Ile Glu Phe Asp Gly Lys Gln Asn Leu Ser 
            260                 265                 270         


Leu Asp Ser Asp Ile Glu Glu Thr Leu Asn Asp Val Val Asp Ile Leu 
        275                 280                 285             


Gly Asp Asn Ile Asp Leu Leu Ile His Ala Lys Glu Val Tyr Asp Ile 
    290                 295                 300                 


Ala Val Leu Thr Ser Ser Leu Gly Lys His Lys Tyr Leu Cys Asp Ala 
305                 310                 315                 320 


Lys Val Glu Leu Phe Glu Lys Asn Lys Lys Asp Leu Met Ile Leu Lys 
                325                 330                 335     


Lys Tyr Ile Lys Lys Asn His Pro Glu Asp Tyr Lys Lys Ile Phe Ser 
            340                 345                 350         


Ser Pro Thr Glu Lys Lys Asn Tyr Ala Ala Tyr Ser Gln Thr Asn Ser 
        355                 360                 365             


Lys Asn Val Cys Ser Gln Glu Glu Phe Cys Leu Phe Ile Lys Pro Tyr 
    370                 375                 380                 


Ile Arg Asp Met Val Lys Ser Glu Asn Glu Asp Glu Val Arg Ile Ala 
385                 390                 395                 400 


Lys Glu Val Glu Asp Lys Ser Phe Leu Thr Lys Leu Lys Gly Thr Asn 
                405                 410                 415     


Asn Ser Val Val Pro Tyr Gln Ile His Glu Arg Glu Leu Asn Gln Ile 
            420                 425                 430         


Leu Lys Asn Ile Val Ala Tyr Leu Pro Phe Met Asn Asp Glu Gln Glu 
        435                 440                 445             


Asp Ile Ser Val Val Asp Lys Ile Lys Leu Ile Phe Lys Phe Lys Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Asn Thr Lys Ser Thr Arg Ser Trp Val 
465                 470                 475                 480 


Tyr Arg Ser Asp Glu Lys Ile Tyr Pro Trp Asn Phe Ser Asn Val Ile 
                485                 490                 495     


Asp Leu Asp Lys Thr Ala His Glu Phe Met Asn Arg Leu Ile Gly Arg 
            500                 505                 510         


Cys Thr Tyr Thr Asn Asp Pro Val Leu Pro Met Asp Ser Leu Leu Tyr 
        515                 520                 525             


Ser Lys Tyr Asn Val Leu Asn Glu Ile Asn Pro Ile Lys Val Asn Gly 
    530                 535                 540                 


Lys Ala Ile Pro Val Glu Val Lys Gln Ala Ile Tyr Thr Asp Leu Phe 
545                 550                 555                 560 


Glu Asn Ser Lys Lys Lys Val Thr Arg Lys Ser Ile Tyr Ile Tyr Leu 
                565                 570                 575     


Leu Lys Asn Gly Tyr Ile Glu Lys Glu Asp Ile Val Ser Gly Ile Asp 
            580                 585                 590         


Ile Glu Ile Lys Ser Lys Leu Lys Ser His His Asp Phe Thr Gln Ile 
        595                 600                 605             


Val Gln Glu Asn Lys Cys Thr Pro Glu Glu Ile Glu Arg Ile Ile Lys 
    610                 615                 620                 


Gly Ile Leu Val Tyr Ser Asp Asp Lys Ser Met Leu Arg Arg Trp Leu 
625                 630                 635                 640 


Lys Asn Asn Ile Lys Gly Leu Ser Glu Asn Asp Val Lys Tyr Leu Ala 
                645                 650                 655     


Lys Leu Asn Tyr Lys Glu Trp Gly Arg Leu Ser Lys Thr Leu Leu Thr 
            660                 665                 670         


Asp Ile Tyr Thr Ile Asn Pro Glu Asp Gly Glu Ala Cys Ser Ile Leu 
        675                 680                 685             


Asp Ile Met Trp Asn Thr Asn Ala Thr Leu Met Glu Ile Leu Ser Asn 
    690                 695                 700                 


Glu Lys Tyr Gln Phe Lys Gln Asn Ile Glu Asn Tyr Lys Ala Glu Asn 
705                 710                 715                 720 


Tyr Asp Glu Lys Gln Asn Leu His Glu Glu Leu Asp Asp Met Tyr Ile 
                725                 730                 735     


Ser Pro Ala Ala Arg Arg Ser Ile Trp Gln Ala Leu Arg Ile Val Asp 
            740                 745                 750         


Glu Ile Val Asp Ile Lys Lys Ser Ala Pro Lys Lys Ile Phe Ile Glu 
        755                 760                 765             


Met Ala Arg Glu Lys Lys Ser Ala Met Lys Lys Lys Arg Thr Glu Ser 
    770                 775                 780                 


Arg Lys Asp Thr Leu Leu Glu Leu Tyr Lys Ser Cys Lys Ser Gln Ala 
785                 790                 795                 800 


Asp Gly Phe Tyr Asp Glu Glu Leu Phe Glu Lys Leu Ser Asn Glu Ser 
                805                 810                 815     


Asn Ser Arg Leu Arg Arg Asp Gln Leu Tyr Leu Tyr Tyr Thr Gln Met 
            820                 825                 830         


Gly Arg Ser Met Tyr Thr Gly Lys Arg Ile Asp Phe Asp Lys Leu Ile 
        835                 840                 845             


Asn Asp Lys Asn Thr Tyr Asp Ile Asp His Ile Tyr Pro Arg Ser Lys 
    850                 855                 860                 


Ile Lys Asp Asp Ser Ile Thr Asn Arg Val Leu Val Glu Lys Asp Ile 
865                 870                 875                 880 


Asn Gly Glu Lys Thr Asp Ile Tyr Pro Ile Ser Glu Asp Ile Arg Gln 
                885                 890                 895     


Lys Met Gln Pro Phe Trp Lys Ile Leu Lys Glu Lys Gly Leu Ile Asn 
            900                 905                 910         


Glu Glu Lys Tyr Lys Arg Leu Thr Arg Asn Tyr Glu Leu Thr Asp Glu 
        915                 920                 925             


Glu Leu Ser Ser Phe Val Ala Arg Gln Leu Val Glu Thr Gln Gln Ser 
    930                 935                 940                 


Thr Lys Ala Leu Ala Thr Leu Leu Lys Lys Glu Tyr Pro Ser Ala Lys 
945                 950                 955                 960 


Ile Val Tyr Ser Lys Ala Gly Asn Val Ser Glu Phe Arg Asn Arg Lys 
                965                 970                 975     


Asp Lys Glu Leu Pro Lys Phe Arg Glu Ile Asn Asp Leu His His Ala 
            980                 985                 990         


Lys Asp Ala Tyr Leu Asn Ile Val  Val Gly Asn Val Tyr  Asp Thr Lys 
        995                 1000                 1005             


Phe Thr  Glu Lys Phe Phe Asn  Asn Ile Arg Asn Glu  Asn Tyr Ser 
    1010                 1015                 1020             


Leu Lys  Arg Val Phe Asp Phe  Ser Val Pro Gly Ala  Trp Asp Ala 
    1025                 1030                 1035             


Lys Gly  Ser Thr Phe Asn Thr  Ile Lys Lys Tyr Met  Ala Lys Asn 
    1040                 1045                 1050             


Asn Pro  Ile Ile Ala Phe Ala  Pro Tyr Glu Val Lys  Gly Glu Leu 
    1055                 1060                 1065             


Phe Asp  Gln Gln Ile Val Pro  Lys Gly Lys Gly Gln  Phe Pro Ile 
    1070                 1075                 1080             


Lys Gln  Gly Lys Asp Ile Glu  Lys Tyr Gly Gly Tyr  Asn Lys Leu 
    1085                 1090                 1095             


Ser Ser  Ala Phe Leu Phe Ala  Val Glu Tyr Lys Gly  Lys Lys Ala 
    1100                 1105                 1110             


Arg Glu  Arg Ser Leu Glu Thr  Val Tyr Ile Lys Asp  Val Glu Leu 
    1115                 1120                 1125             


Tyr Leu  Gln Asp Pro Ile Lys  Tyr Cys Glu Ser Val  Leu Gly Leu 
    1130                 1135                 1140             


Lys Glu  Pro Gln Ile Ile Lys  Pro Lys Ile Leu Met  Gly Ser Leu 
    1145                 1150                 1155             


Phe Ser  Ile Asn Asn Lys Lys  Leu Val Val Thr Gly  Arg Ser Gly 
    1160                 1165                 1170             


Lys Gln  Tyr Val Cys His His  Ile Tyr Gln Leu Ser  Ile Asn Asp 
    1175                 1180                 1185             


Glu Asp  Ser Gln Tyr Leu Lys  Asn Ile Ala Lys Tyr  Leu Gln Glu 
    1190                 1195                 1200             


Glu Pro  Asp Gly Asn Ile Glu  Arg Gln Asn Ile Leu  Asn Ile Thr 
    1205                 1210                 1215             


Ser Val  Asn Asn Ile Lys Leu  Phe Asp Val Leu Cys  Thr Lys Phe 
    1220                 1225                 1230             


Asn Ser  Asn Thr Tyr Glu Ile  Ile Leu Asn Ser Leu  Lys Asn Asp 
    1235                 1240                 1245             


Val Asn  Glu Gly Arg Glu Lys  Phe Ser Glu Leu Asp  Ile Leu Glu 
    1250                 1255                 1260             


Gln Cys  Asn Ile Leu Leu Gln  Leu Leu Lys Ala Phe  Lys Cys Asn 
    1265                 1270                 1275             


Arg Glu  Ser Ser Asn Leu Glu  Lys Leu Asn Asn Lys  Lys Gln Ala 
    1280                 1285                 1290             


Gly Val  Ile Val Ile Pro His  Leu Phe Thr Lys Cys  Ser Val Phe 
    1295                 1300                 1305             


Lys Val  Ile His Gln Ser Ile  Thr Gly Leu Phe Glu  Lys Glu Met 
    1310                 1315                 1320             


Asp Leu  Leu Lys 
    1325         


<210> 422
<211> 1179
<212> PRT
<213> Sphaerochaeta globosa

<400> 422
Met Ser Lys Lys Val Ser Arg Arg Tyr Glu Glu Gln Ala Gln Glu Ile 
1               5                   10                  15      


Cys Gln Arg Leu Gly Ser Arg Pro Tyr Ser Ile Gly Leu Asp Leu Gly 
            20                  25                  30          


Val Gly Ser Ile Gly Val Ala Val Ala Ala Tyr Asp Pro Ile Lys Lys 
        35                  40                  45              


Gln Pro Ser Asp Leu Val Phe Val Ser Ser Arg Ile Phe Ile Pro Ser 
    50                  55                  60                  


Thr Gly Ala Ala Glu Arg Arg Gln Lys Arg Gly Gln Arg Asn Ser Leu 
65                  70                  75                  80  


Arg His Arg Ala Asn Arg Leu Lys Phe Leu Trp Lys Leu Leu Ala Glu 
                85                  90                  95      


Arg Asn Leu Met Leu Ser Tyr Ser Glu Gln Asp Val Pro Asp Pro Ala 
            100                 105                 110         


Arg Leu Arg Phe Glu Asp Ala Val Val Arg Ala Asn Pro Tyr Glu Leu 
        115                 120                 125             


Arg Leu Lys Gly Leu Asn Glu Gln Leu Thr Leu Ser Glu Leu Gly Tyr 
    130                 135                 140                 


Ala Leu Tyr His Ile Ala Asn His Arg Gly Ser Ser Ser Val Arg Thr 
145                 150                 155                 160 


Phe Leu Asp Glu Glu Lys Ser Ser Asp Asp Lys Lys Leu Glu Glu Gln 
                165                 170                 175     


Gln Ala Met Thr Glu Gln Leu Ala Lys Glu Lys Gly Ile Ser Thr Phe 
            180                 185                 190         


Ile Glu Val Leu Thr Ala Phe Asn Thr Asn Gly Leu Ile Gly Tyr Arg 
        195                 200                 205             


Asn Ser Glu Ser Val Lys Ser Lys Gly Val Pro Val Pro Thr Arg Asp 
    210                 215                 220                 


Ile Ile Ser Asn Glu Ile Asp Val Leu Leu Gln Thr Gln Lys Gln Phe 
225                 230                 235                 240 


Tyr Gln Glu Ile Leu Ser Asp Glu Tyr Cys Asp Arg Ile Val Ser Ala 
                245                 250                 255     


Ile Leu Phe Glu Asn Glu Lys Ile Val Pro Glu Ala Gly Cys Cys Pro 
            260                 265                 270         


Tyr Phe Pro Asp Glu Lys Lys Leu Pro Arg Cys His Phe Leu Asn Glu 
        275                 280                 285             


Glu Arg Arg Leu Trp Glu Ala Ile Asn Asn Ala Arg Ile Lys Met Pro 
    290                 295                 300                 


Met Gln Glu Gly Ala Ala Lys Arg Tyr Gln Ser Ala Ser Phe Ser Asp 
305                 310                 315                 320 


Glu Gln Arg His Ile Leu Phe His Ile Ala Arg Ser Gly Thr Asp Ile 
                325                 330                 335     


Thr Pro Lys Leu Val Gln Lys Glu Phe Pro Ala Leu Lys Thr Ser Ile 
            340                 345                 350         


Ile Val Leu Gln Gly Lys Glu Lys Ala Ile Gln Lys Ile Ala Gly Phe 
        355                 360                 365             


Arg Phe Arg Arg Leu Glu Glu Lys Ser Phe Trp Lys Arg Leu Ser Glu 
    370                 375                 380                 


Glu Gln Lys Asp Asp Phe Phe Ser Ala Trp Thr Asn Thr Pro Asp Asp 
385                 390                 395                 400 


Lys Arg Leu Ser Lys Tyr Leu Met Lys His Leu Leu Leu Thr Glu Asn 
                405                 410                 415     


Glu Val Val Asp Ala Leu Lys Thr Val Ser Leu Ile Gly Asp Tyr Gly 
            420                 425                 430         


Pro Ile Gly Lys Thr Ala Thr Gln Leu Leu Met Lys His Leu Glu Asp 
        435                 440                 445             


Gly Leu Thr Tyr Thr Glu Ala Leu Glu Arg Gly Met Glu Thr Gly Glu 
    450                 455                 460                 


Phe Gln Glu Leu Ser Val Trp Glu Gln Gln Ser Leu Leu Pro Tyr Tyr 
465                 470                 475                 480 


Gly Gln Ile Leu Thr Gly Ser Thr Gln Ala Leu Met Gly Lys Tyr Trp 
                485                 490                 495     


His Ser Ala Phe Lys Glu Lys Arg Asp Ser Glu Gly Phe Phe Lys Pro 
            500                 505                 510         


Asn Thr Asn Ser Asp Glu Glu Lys Tyr Gly Arg Ile Ala Asn Pro Val 
        515                 520                 525             


Val His Gln Thr Leu Asn Glu Leu Arg Lys Leu Met Asn Glu Leu Ile 
    530                 535                 540                 


Thr Ile Leu Gly Ala Lys Pro Gln Glu Ile Thr Val Glu Leu Ala Arg 
545                 550                 555                 560 


Glu Leu Lys Val Gly Ala Glu Lys Arg Glu Asp Ile Ile Lys Gln Gln 
                565                 570                 575     


Thr Lys Gln Glu Lys Glu Ala Val Leu Ala Tyr Ser Lys Tyr Cys Glu 
            580                 585                 590         


Pro Asn Asn Leu Asp Lys Arg Tyr Ile Glu Arg Phe Arg Leu Leu Glu 
        595                 600                 605             


Asp Gln Ala Phe Val Cys Pro Tyr Cys Leu Glu His Ile Ser Val Ala 
    610                 615                 620                 


Asp Ile Ala Ala Gly Arg Ala Asp Val Asp His Ile Phe Pro Arg Asp 
625                 630                 635                 640 


Asp Thr Ala Asp Asn Ser Tyr Gly Asn Lys Val Val Ala His Arg Gln 
                645                 650                 655     


Cys Asn Asp Ile Lys Gly Lys Arg Thr Pro Tyr Ala Ala Phe Ser Asn 
            660                 665                 670         


Thr Ser Ala Trp Gly Pro Ile Met His Tyr Leu Asp Glu Thr Pro Gly 
        675                 680                 685             


Met Trp Arg Lys Arg Arg Lys Phe Glu Thr Asn Glu Glu Glu Tyr Ala 
    690                 695                 700                 


Lys Tyr Leu Gln Ser Lys Gly Phe Val Ser Arg Phe Glu Ser Asp Asn 
705                 710                 715                 720 


Ser Tyr Ile Ala Lys Ala Ala Lys Glu Tyr Leu Arg Cys Leu Phe Asn 
                725                 730                 735     


Pro Asn Asn Val Thr Ala Val Gly Ser Leu Lys Gly Met Glu Thr Ser 
            740                 745                 750         


Ile Leu Arg Lys Ala Trp Asn Leu Gln Gly Ile Asp Asp Leu Leu Gly 
        755                 760                 765             


Ser Arg His Trp Ser Lys Asp Ala Asp Thr Ser Pro Thr Met Arg Lys 
    770                 775                 780                 


Asn Arg Asp Asp Asn Arg His His Gly Leu Asp Ala Ile Val Ala Leu 
785                 790                 795                 800 


Tyr Cys Ser Arg Ser Leu Val Gln Met Ile Asn Thr Met Ser Glu Gln 
                805                 810                 815     


Gly Lys Arg Ala Val Glu Ile Glu Ala Met Ile Pro Ile Pro Gly Tyr 
            820                 825                 830         


Ala Ser Glu Pro Asn Leu Ser Phe Glu Ala Gln Arg Glu Leu Phe Arg 
        835                 840                 845             


Lys Lys Ile Leu Glu Phe Met Asp Leu His Ala Phe Val Ser Met Lys 
    850                 855                 860                 


Thr Asp Asn Asp Ala Asn Gly Ala Leu Leu Lys Asp Thr Val Tyr Ser 
865                 870                 875                 880 


Ile Leu Gly Ala Asp Thr Gln Gly Glu Asp Leu Val Phe Val Val Lys 
                885                 890                 895     


Lys Lys Ile Lys Asp Ile Gly Val Lys Ile Gly Asp Tyr Glu Glu Val 
            900                 905                 910         


Ala Ser Ala Ile Arg Gly Arg Ile Thr Asp Lys Gln Pro Lys Trp Tyr 
        915                 920                 925             


Pro Met Glu Met Lys Asp Lys Ile Glu Gln Leu Gln Ser Lys Asn Glu 
    930                 935                 940                 


Ala Ala Leu Gln Lys Tyr Lys Glu Ser Leu Val Gln Ala Ala Ala Val 
945                 950                 955                 960 


Leu Glu Glu Ser Asn Arg Lys Leu Ile Glu Ser Gly Lys Lys Pro Ile 
                965                 970                 975     


Gln Leu Ser Glu Lys Thr Ile Ser Lys Lys Ala Leu Glu Leu Val Gly 
            980                 985                 990         


Gly Tyr Tyr Tyr Leu Ile Ser Asn  Asn Lys Arg Thr Lys  Thr Phe Val 
        995                 1000                 1005             


Val Lys  Glu Pro Ser Asn Glu  Val Lys Gly Phe Ala  Phe Asp Thr 
    1010                 1015                 1020             


Gly Ser  Asn Leu Cys Leu Asp  Phe Tyr His Asp Ala  Gln Gly Lys 
    1025                 1030                 1035             


Leu Cys  Gly Glu Ile Ile Arg  Lys Ile Gln Ala Met  Asn Pro Ser 
    1040                 1045                 1050             


Tyr Lys  Pro Ala Tyr Met Lys  Gln Gly Tyr Ser Leu  Tyr Val Arg 
    1055                 1060                 1065             


Leu Tyr  Gln Gly Asp Val Cys  Glu Leu Arg Ala Ser  Asp Leu Thr 
    1070                 1075                 1080             


Glu Ala  Glu Ser Asn Leu Ala  Lys Thr Thr His Val  Arg Leu Pro 
    1085                 1090                 1095             


Asn Ala  Lys Pro Gly Arg Thr  Phe Val Ile Ile Ile  Thr Phe Thr 
    1100                 1105                 1110             


Glu Met  Gly Ser Gly Tyr Gln  Ile Tyr Phe Ser Asn  Leu Ala Lys 
    1115                 1120                 1125             


Ser Lys  Lys Gly Gln Asp Thr  Ser Phe Thr Leu Thr  Thr Ile Lys 
    1130                 1135                 1140             


Asn Tyr  Asp Val Arg Lys Val  Gln Leu Ser Ser Ala  Gly Leu Val 
    1145                 1150                 1155             


Arg Tyr  Val Ser Pro Leu Leu  Val Asp Lys Ile Glu  Lys Asp Glu 
    1160                 1165                 1170             


Val Ala  Leu Cys Gly Glu 
    1175                 


<210> 423
<211> 1426
<212> PRT
<213> Sphingobacterium spiritivorum


<220>
<223> Sphingobacterium spiritivorum ATCC 33861

<400> 423
Met Lys His Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Ile Lys Gln Asp Phe Glu Asn Lys Gln Gly Glu Ile Leu Gly 
            20                  25                  30          


Met Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Ile Leu Gly Asp Phe 
        35                  40                  45              


Gly Lys Gly Asn Ser Val Ser Gln Thr Ala Glu Arg Thr Lys Tyr Arg 
    50                  55                  60                  


Ser Val Arg Arg Leu Arg Glu Arg Phe Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Ile Leu Asn Val Leu Gly Phe Leu Pro Glu His Tyr Ala Ser 
                85                  90                  95      


Gln Ile Asp Phe Thr Lys Arg Phe Gly Lys Phe Lys Glu Glu Thr Glu 
            100                 105                 110         


Pro Lys Leu Val Tyr Ser Asn Glu Gly Phe Ile Phe Lys Lys Ser Phe 
        115                 120                 125             


Glu Glu Met Leu Ser Asp Phe Lys Thr His Gln Pro Gln Leu Leu Glu 
    130                 135                 140                 


Asp Asn Lys Lys Ile Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys 
145                 150                 155                 160 


Lys Ala Leu Ser Arg Lys Ile Glu Lys Glu Glu Leu Ala Trp Ile Leu 
                165                 170                 175     


Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu 
            180                 185                 190         


Glu Glu Glu Asn Pro Asn Lys Leu Ile Glu Phe Tyr Ser Leu Lys Ile 
        195                 200                 205             


Val Asp Val Leu Ala Asp Glu Pro Gln Lys Gly Lys Ser Asp Ile Trp 
    210                 215                 220                 


Tyr Ser Leu Ile Leu Glu Asn Gly Trp Ile Tyr Arg Arg Ser Ser Lys 
225                 230                 235                 240 


Thr Pro Leu Phe Asp Trp Lys Glu Lys Thr Arg Asp Phe Ile Val Thr 
                245                 250                 255     


Ile Asp Leu Asn Asp Asp Gly Ser Val Lys Thr Asp Lys Glu Gly Asn 
            260                 265                 270         


Glu Lys Arg Ser Phe Arg Ala Pro Gly Glu Asn Asp Trp Thr Leu Val 
        275                 280                 285             


Lys Lys Lys Thr Glu Gln Glu Ile Asp Ser Ser Arg Lys Thr Val Gly 
    290                 295                 300                 


Thr Tyr Ile Tyr Glu Thr Leu Leu Lys Asn Pro Lys Gln Lys Ile Lys 
305                 310                 315                 320 


Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Phe Tyr Lys Thr Glu Leu 
                325                 330                 335     


Lys Gln Ile Leu Glu Lys Gln Lys Glu Phe His Pro Glu Leu Arg Gln 
            340                 345                 350         


Asp Asp Leu Tyr Ser Asp Cys Val Arg Glu Leu Tyr Lys Asn Asn Glu 
        355                 360                 365             


Ala His Gln Leu Thr Leu Ser Lys Lys Asp Phe Val His Leu Phe Met 
    370                 375                 380                 


Glu Asp Ile Ile Phe Tyr Gln Arg Pro Leu Gly Ser Gln Lys Ser Ser 
385                 390                 395                 400 


Ile Ser Asn Cys Thr Leu Glu Phe Arg Lys Tyr Lys Asp Glu Asn Gly 
                405                 410                 415     


Thr Glu His Thr Gln Tyr Leu Lys Ala Ile Pro Lys Ser Asn Pro Tyr 
            420                 425                 430         


Tyr Gln Glu Phe Arg Ile Trp Gln Trp Met Tyr Asn Leu Asn Ile Tyr 
        435                 440                 445             


Lys Lys Glu Asp Asp Thr Asn Val Thr Lys Asp Phe Leu Asn Thr Lys 
    450                 455                 460                 


Ala Asp Phe Glu Ser Leu Phe Glu Phe Leu Asn Asn Arg Lys Glu Val 
465                 470                 475                 480 


Asp Gln Lys Ala Leu Leu Lys His Phe Lys Leu Asn Asp Lys Thr His 
                485                 490                 495     


Arg Trp Asn Tyr Val Glu Asp Lys Lys Tyr Pro Cys Asn Glu Thr Lys 
            500                 505                 510         


Thr Met Ile Leu Ser Arg Leu Asp Lys Val Glu Asn Ile Ser Asp Asp 
        515                 520                 525             


Phe Leu Thr Arg Glu Met Glu Gln Lys Ile Trp His Ile Ile Tyr Ser 
    530                 535                 540                 


Val Asn Asp Lys Val Glu Tyr Glu Lys Ala Leu Lys Ser Phe Ala Gly 
545                 550                 555                 560 


Lys Asn Asn Leu Glu Asp Asn Ser Phe Phe Glu Ala Phe Lys Lys Phe 
                565                 570                 575     


Pro Pro Phe Lys Ser Glu Tyr Gly Ala Phe Ser Glu Lys Ala Ile Lys 
            580                 585                 590         


Lys Leu Leu Pro Leu Met Arg Met Gly Lys Phe Trp Asn Tyr Asn Asn 
        595                 600                 605             


Ile Ser Glu Gln Ser Lys Ser Arg Ile Gln Lys Ile Ile Thr Gly Glu 
    610                 615                 620                 


Tyr Asp Glu Asn Ile Lys Asp Lys Val Arg Glu Lys Ala Ile His Leu 
625                 630                 635                 640 


Thr Thr Glu Thr Asp Phe Gln Gly Leu Gln Leu Trp Leu Val Gln Tyr 
                645                 650                 655     


Ile Val Tyr Gly Arg His Ser Glu Ala Ala Met Leu Gly Lys Trp Asn 
            660                 665                 670         


Ser Ala Asp Asp Leu Glu Glu Phe Leu Lys Glu Phe Lys Gln His Ser 
        675                 680                 685             


Leu Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val 
    690                 695                 700                 


Val Lys Asp Ile Trp Gln Lys Tyr Gly Asn Gly Ala Lys Asp Phe Phe 
705                 710                 715                 720 


Arg Glu Ile His Ile Glu Leu Gly Arg Glu Met Lys Leu Pro Ala Glu 
                725                 730                 735     


Glu Arg Glu Arg Leu Thr Arg Gln Ile Ser Glu Asn Glu Asn Thr Asn 
            740                 745                 750         


Phe Arg Ile Lys Ala Leu Leu Ala Glu Met Met Asp Asp Asn Ser Val 
        755                 760                 765             


Glu Asn Val Arg Pro Phe Ser Pro Met Gln Gln Glu Ile Leu Lys Ile 
    770                 775                 780                 


Tyr Glu Glu Gly Val Leu Asn Ser Asp Ile Glu Ile Glu Asp Asp Ile 
785                 790                 795                 800 


Leu Lys Ile Ser Lys Thr Ala Gln Pro Ser Ser Ser Asp Leu Lys Arg 
                805                 810                 815     


Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Lys Ser Pro Tyr Thr Gly Gln 
            820                 825                 830         


Ile Ile Pro Leu Asn Lys Leu Phe Thr Pro Glu Tyr Glu Ile Glu His 
        835                 840                 845             


Ile Ile Pro Gln Ser Arg Tyr Phe Asp Asp Ser Phe Thr Asn Lys Ile 
    850                 855                 860                 


Ile Cys Glu Ser Ala Val Asn Lys Leu Lys Asp Asn Tyr Ile Gly Leu 
865                 870                 875                 880 


Glu Phe Ile Lys Lys Leu Gly Gly Ser Ile Val Glu Cys Gly Asn Gly 
                885                 890                 895     


Lys Ser Val Ala Ile Leu Lys His Asp Ala Tyr Glu Asp Phe Ile Lys 
            900                 905                 910         


Lys His Tyr Ala Asn Asn Arg Ser Lys Arg Asn Lys Leu Leu Leu Glu 
        915                 920                 925             


Asp Ile Pro Glu Lys Met Ile Glu Arg Gln Met Asn Asp Thr Arg Tyr 
    930                 935                 940                 


Ile Ser Lys Tyr Ile Ser Gly Val Leu Ser Asn Ile Val Arg Val Glu 
945                 950                 955                 960 


Asp Gly Thr Asp Glu Gly Val Asn Ser Lys Asn Ile Val Pro Gly Asn 
                965                 970                 975     


Gly Lys Ile Thr Thr Gln Leu Lys Gln Asp Trp Gly Leu Asn Asp Val 
            980                 985                 990         


Trp Asn Asp Leu Ile Leu Pro Arg  Phe Glu Arg Met Asn  His Leu Thr 
        995                 1000                 1005             


Asn Ser  Thr Asp Phe Thr Ala  Trp Asn Glu Asn His  Gln Lys Phe 
    1010                 1015                 1020             


Leu Pro  Thr Val Pro Val Glu  Phe Ser Lys Gly Phe  Ser Lys Lys 
    1025                 1030                 1035             


Arg Ile  Asp His Arg His His  Ala Leu Asp Ala Leu  Val Ile Ala 
    1040                 1045                 1050             


Cys Ala  Thr Lys Asp His Val  Asn Leu Leu Asn Asn  Gln Ser Ala 
    1055                 1060                 1065             


Lys Ser  Asp Thr Lys Arg Tyr  Asp Leu Lys Lys Lys  Leu Met Lys 
    1070                 1075                 1080             


Phe Glu  Lys Val Ala Tyr Asn  His Pro Gln Thr Gly  Glu Arg Ile 
    1085                 1090                 1095             


Glu Arg  Glu Ala Pro Lys Gln  Phe Leu Lys Pro Trp  Glu Thr Phe 
    1100                 1105                 1110             


Thr Ile  Asp Ala Lys Asn His  Leu Glu Thr Ile Ile  Val Ser Phe 
    1115                 1120                 1125             


Lys Gln  Asn Leu Arg Val Ile  Asn Lys Ala Thr Asn  Tyr Tyr Glu 
    1130                 1135                 1140             


Lys Tyr  Val Glu Lys Glu Gly  Thr Lys Val Lys Glu  Arg Val Glu 
    1145                 1150                 1155             


Gln Lys  Gly Thr Asn Trp Ala  Ile Arg Lys Pro Met  His Lys Glu 
    1160                 1165                 1170             


Thr Val  Ser Gly Lys Ile Asp  Leu Pro Arg Ile Lys  Val Pro Lys 
    1175                 1180                 1185             


Gly Lys  Ile Leu Thr Ala Thr  Arg Lys Ser Leu Asp  Thr Ser Phe 
    1190                 1195                 1200             


Asn Leu  Lys Thr Ile Gly Ser  Ile Thr Asp Thr Gly  Ile Gln Lys 
    1205                 1210                 1215             


Ile Leu  Lys Asn Tyr Leu Gln  Tyr Lys Asp Asn Asn  Pro Glu Leu 
    1220                 1225                 1230             


Ala Phe  Ser Pro Glu Gly Ile  Glu Asp Met Asn Lys  Asn Ile Glu 
    1235                 1240                 1245             


Lys Phe  Asn Asn Gly Lys Ala  His Gln Ser Ile Ser  Lys Val Arg 
    1250                 1255                 1260             


Val Phe  Glu Leu Gly Ser Lys  Phe Pro Leu Gly Gln  Ser Gly Asn 
    1265                 1270                 1275             


Lys Lys  Glu Lys Tyr Val Glu  Ala Ala Lys Gly Thr  Asn Leu Phe 
    1280                 1285                 1290             


Phe Ala  Ile Tyr Gln Asp Lys  Asn Gly Lys Arg Ser  Tyr Glu Thr 
    1295                 1300                 1305             


Ile Pro  Leu Asn Glu Val Ile  Glu Arg Gln Lys Gln  Gly Leu Ser 
    1310                 1315                 1320             


Val Val  Asp Leu Lys Gly Val  Asp Asp Phe Tyr Leu  Ser Pro Asn 
    1325                 1330                 1335             


Asp Leu  Val Tyr Val Pro Ser  Glu Asp Glu Leu Glu  Asn Ile Ser 
    1340                 1345                 1350             


Met Ile  Asp Phe Asn Lys Met  Ser Ser Glu Arg Ile  Tyr Lys Val 
    1355                 1360                 1365             


Val Ser  Phe Thr Gly Asn Gln  Ile Phe Phe Val Arg  Gln Asp Ile 
    1370                 1375                 1380             


Ala Thr  Ser Val Val Asn Lys  Ala Glu Phe Ser Thr  Leu Asn Lys 
    1385                 1390                 1395             


Met Glu  Arg Ala Ile Asp Gly  Thr Met Ile Lys Glu  Thr Cys Val 
    1400                 1405                 1410             


Lys Leu  Gln Ile Asp Arg Leu  Gly Asn Ile Ser Lys  Ile 
    1415                 1420                 1425     


<210> 424
<211> 1110
<212> PRT
<213> Sphingobium sp.


<220>
<223> Sphingobium sp. AP49

<400> 424
Met Ala Glu Gly Lys Lys Arg Ile Trp Arg Leu Gly Ala Asp Leu Gly 
1               5                   10                  15      


Ala Asn Ser Leu Gly Trp Ala Ala Ile Glu Leu Ser Ala Pro Val Asn 
            20                  25                  30          


Gly Lys Pro Ile Ala Ile Leu Ala Ala Gly Ser Arg Ile Phe Ser Asp 
        35                  40                  45              


Gly Arg Asp Pro Lys Ser Gly Ala Ser Leu Ala Val Asp Arg Arg Asp 
    50                  55                  60                  


Ala Arg Ala Met Arg Arg Arg Arg Asp Arg Phe Lys Gln Arg Gln Lys 
65                  70                  75                  80  


Ala Leu Ile Lys Tyr Leu Ile Ala Asp Gly Leu Phe Pro Ala Asp Glu 
                85                  90                  95      


Ala Ala Arg Asn Ala Met Ala Ala Ile Asp Pro Tyr Ala Val Arg Ala 
            100                 105                 110         


Arg Ala Leu Asp Glu Ala Leu Ser Leu Pro Glu Leu Gly Arg Ala Leu 
        115                 120                 125             


Phe His Leu Asn Gln Arg Arg Gly Phe Lys Ser Asn Arg Lys Ala Asp 
    130                 135                 140                 


Arg Lys Ala Asp Asp Asp Ala Gly Lys Ile Ala Ile Gly Ile Asp Arg 
145                 150                 155                 160 


Thr Arg Asp Ala Ile Ala Glu Asp Glu Ala Asp Ala Gly Ala Glu Pro 
                165                 170                 175     


Gly Ser Trp Thr Phe Gly Lys Trp Leu His Glu Arg Arg Leu Lys Gly 
            180                 185                 190         


Gln Ser Val Arg Thr Arg Leu Arg Pro Glu Ser Gly Glu Asp Ala Lys 
        195                 200                 205             


Gly Asp Gly Tyr Asp Phe Tyr Pro Asp Arg Ala Leu Met Glu Glu Glu 
    210                 215                 220                 


Phe Asp Ala Ile Trp Ala Ala Gln Ala Pro His His Pro Asp Val Leu 
225                 230                 235                 240 


Thr Asn Asp Val His Asp Arg Leu His Glu Ile Ile Phe Tyr Gln Arg 
                245                 250                 255     


Pro Leu Lys Ala Pro Gln Val Gly Met Cys Ser Leu Ile Pro Gly Asp 
            260                 265                 270         


Arg Arg Leu Pro Lys Ala His Pro Leu Phe Gln Arg Arg Arg Leu Leu 
        275                 280                 285             


Glu Glu Leu Asn Ala Leu Met Ile Val Arg Pro Gly Glu Val Ala Gln 
    290                 295                 300                 


Arg Leu Thr Arg Glu Glu Arg Asp Ile Leu Leu Leu Lys Leu Lys Asp 
305                 310                 315                 320 


Lys Asn Lys Val Ser Phe Ala Thr Leu Arg Lys Ala Leu Lys Leu Asp 
                325                 330                 335     


Pro Asp Ala Arg Phe Asn Lys Glu Ser Glu Asp Arg Thr Asp Leu Lys 
            340                 345                 350         


Gly Asp Glu Val Ala Ala Val Met Gly Ser Lys Thr Arg Phe Gly Asn 
        355                 360                 365             


Leu Trp Val His Leu Ser Ile Glu Ala Gln Trp Asp Val Leu Ala Arg 
    370                 375                 380                 


Leu Asp Ala Val Glu Ser Asp Ala Glu Asp Ala Ala Phe Cys Ala Trp 
385                 390                 395                 400 


Leu Val Glu Thr Tyr Ala Leu Thr Pro Glu Gln Ala Arg Ala Val Ala 
                405                 410                 415     


Asn Ala Pro Leu Pro Pro Gly Tyr Gly Arg Phe Gly Glu Thr Ala Thr 
            420                 425                 430         


Arg Lys Leu Ile Glu Ala Leu Arg Asp Gly Lys Lys Asp Asp Arg Val 
        435                 440                 445             


Leu Val Tyr Ser Glu Ala Val Thr Glu Ala Gly Leu Gly His His Ser 
    450                 455                 460                 


Asp Arg Arg Thr Gly Glu Val Phe Glu Asp Ala Lys Gly Arg Pro Gln 
465                 470                 475                 480 


Leu Pro Tyr Tyr Gly Val Ala Leu Glu Arg His Ile Met Pro Gly Thr 
                485                 490                 495     


Gly Asp Pro Ser Asp Pro Glu Glu Met Arg Val Gly Arg Leu Thr Asn 
            500                 505                 510         


Pro Thr Val His Ile Gly Leu Asn Gln Leu Arg Arg Ile Leu Asn Val 
        515                 520                 525             


Leu Ile Arg Ala Tyr Gly Pro Pro Ala Glu Ile Ala Ile Glu Leu Ala 
    530                 535                 540                 


Arg Glu Leu Lys Leu Thr Asp Glu Asp Lys Lys Arg Ile Asn Arg Glu 
545                 550                 555                 560 


Asn Asn Asp Asn Arg Ile Ala Ala Glu Arg Arg Ser Glu Lys Leu Leu 
                565                 570                 575     


Ala Ile Gly Gln Ala Asp Ser Gly Ala Asn Arg Ala Leu Leu Lys Leu 
            580                 585                 590         


Trp Glu Glu Leu Asn Pro Ala Asn Val Leu Asp Arg Arg Cys Ile Tyr 
        595                 600                 605             


Ser Gly Arg Gln Ile Ser Ile Asp Met Leu Phe Ser Ala Ala Val Glu 
    610                 615                 620                 


Val Asp His Ile Leu Pro Phe Ala Ala Thr Leu Asp Asp Ser Asn Gly 
625                 630                 635                 640 


Asn Lys Ile Val Cys Leu Arg Glu Ala Asn Arg Glu Lys Arg Lys Arg 
                645                 650                 655     


Ser Pro His Asp Ala Trp Gly His Ser Ala Arg Trp Asp Glu Ile Ala 
            660                 665                 670         


Ala Arg Ala Ala Gln Leu Pro Arg Asn Lys Arg Trp Arg Phe Glu Pro 
        675                 680                 685             


Asp Ala Met Asp Lys Phe Arg Asp Glu Gly Gly Phe Gln Ala Arg His 
    690                 695                 700                 


Leu Val Asp Thr Gln Tyr Leu Ala Arg Leu Ser Arg Glu Tyr Leu Ala 
705                 710                 715                 720 


Thr Leu Tyr Pro Glu Lys Gly Glu Gly Ser Gly His Ile Trp Val Ser 
                725                 730                 735     


Pro Gly Arg Leu Thr Glu Met Val Arg Arg Lys Leu Gly Leu Asn Asp 
            740                 745                 750         


Leu Leu Pro Asp His Asn Phe Gly Gly Gly Ala Asp Gln Ala Lys Asn 
        755                 760                 765             


Arg Leu Asp His Arg His His Ala Ile Asp Ala Val Val Val Ala Ile 
    770                 775                 780                 


Val Asp Arg Gly Met Leu Asn Ala Ile Ala Arg Ala Ser Gly Gln Glu 
785                 790                 795                 800 


Gly Ala Glu Gly Arg Glu Arg Ile Ile Ile Pro Glu Pro Trp Asp Gly 
                805                 810                 815     


Phe Arg Asp Ala Leu Arg Glu Thr Val Asn Arg Ile Thr Val Ser His 
            820                 825                 830         


Arg Thr Asp His Gly Thr Ala Ser Lys Ala Gly Leu Pro Lys Gly Lys 
        835                 840                 845             


Asp Ala Thr Ala Gly Arg Leu His Asn Asp Thr Ala Tyr Gly Phe Thr 
    850                 855                 860                 


Gly Asp Thr Asp Ala Lys Gly Asn Ser Ile Val Val Arg Arg Val Pro 
865                 870                 875                 880 


Leu Ser Ser Phe Lys Lys Leu Ala Asp Leu Asp Arg Ile Arg Asp Ala 
                885                 890                 895     


Asp Leu Lys Ala Ala Leu Tyr Gln His Leu Asn Gly Leu Glu Gly Lys 
            900                 905                 910         


Ala Phe Glu Lys Ala Leu Ala Glu Phe His Lys Leu Glu Trp His Asn 
        915                 920                 925             


Phe Gly Gly Val Arg Arg Val Arg Val Thr Glu Pro Leu Thr Val Ile 
    930                 935                 940                 


Pro Ile Lys Asp Arg Asn Gly Arg Ile Tyr Lys Gly Tyr Lys Gly Asp 
945                 950                 955                 960 


Ser Asn Tyr Arg Tyr Asp Val Trp Glu Leu Pro Asp Gly Lys Trp Val 
                965                 970                 975     


Thr Asn Trp Lys Asn Glu Ala Gly Glu Ala Met Ser Ser Val Ile Ser 
            980                 985                 990         


Met Phe Asp Ala His Gln Ser Ser  Glu Pro Pro Arg Pro  His Pro Ala 
        995                 1000                 1005             


Ala Arg  Lys Ile Leu Ser Leu  His Gln Asn Asp Leu  Leu Ala Ile 
    1010                 1015                 1020             


Glu Arg  Glu Gly Glu Asp Arg  Lys Leu Met Arg Val  Val Lys Phe 
    1025                 1030                 1035             


Gly Gln  Ser Gly Gln Ile Thr  Leu Ala Glu His Gln  Gln Ala Gly 
    1040                 1045                 1050             


Asp Leu  Lys Lys Arg Asp Ala  Val Ser Asn Asp Asp  Asp Pro Phe 
    1055                 1060                 1065             


Lys Tyr  Phe Ala Pro Thr Ser  Gly Gly Leu Lys Lys  Val Lys Ala 
    1070                 1075                 1080             


Arg Gln  Val Arg Ile Asp Glu  Ile Gly Arg Val Leu  Asp Pro Gly 
    1085                 1090                 1095             


Phe Pro  Ala Arg Thr Ala Arg  Arg Lys Thr Arg Gly  
    1100                 1105                 1110 


<210> 425
<211> 1090
<212> PRT
<213> Sphingomonas sp.


<220>
<223> Sphingomonas sp. S17

<400> 425
Met Asp Trp Arg Leu Gly Leu Asp Leu Gly Ala Asn Ser Leu Gly Trp 
1               5                   10                  15      


Ala Ala Leu Arg Leu Asp Arg Ala Gly Asp Pro Ile Gly Ile Leu Ala 
            20                  25                  30          


Met Gly Ser Arg Ile Phe Ser Asp Gly Arg Asp Pro Lys Ser Gly Ala 
        35                  40                  45              


Ser Leu Ala Val Asp Arg Arg Ala Ala Arg Ala Met Arg Arg Arg Arg 
    50                  55                  60                  


Asp Arg Phe Lys Gln Arg Gln Ala Ala Leu Leu Lys Tyr Leu Ile Arg 
65                  70                  75                  80  


Asp Gly Leu Phe Pro Ala Asp Gln Ala Asp Arg Gln Arg Leu Ala Asp 
                85                  90                  95      


Glu Asp Pro Tyr Ala Leu Arg Ala Arg Ala Leu Asp Glu Glu Leu Ser 
            100                 105                 110         


Leu Phe Glu Ile Gly Arg Ala Leu Phe His Leu Asn Gln Arg Arg Gly 
        115                 120                 125             


Phe Gln Ser Asn Arg Lys Ala Asp Arg Gly Gln Asp Asp Glu Ala Gly 
    130                 135                 140                 


Lys Ile Ala Val Gly Val Asp Arg Leu Asn Gln Gln Met Glu Glu Gln 
145                 150                 155                 160 


Gly Ala Arg Thr Leu Gly Glu Phe Leu His Gln Arg Arg Arg Ala Ala 
                165                 170                 175     


Thr Asp Ala Asn His Ile Pro Ser Val Arg Thr Arg Leu Arg Pro Glu 
            180                 185                 190         


Thr Gly Glu Gly Ala Lys Gly Asp Gly Tyr Asp Phe Tyr Pro Ser Arg 
        195                 200                 205             


Ala Leu Ile Ala Glu Glu Phe Glu Glu Ile Trp Ala Ala Gln Ala Pro 
    210                 215                 220                 


His Tyr Pro Asp Thr Leu Thr Gln Gln Val His Asp Arg Leu Tyr Glu 
225                 230                 235                 240 


Ile Ile Phe His Gln Arg Pro Leu Arg Ala Pro Gln Val Gly Gln Cys 
                245                 250                 255     


Thr Leu Val Ala Gly Glu Thr Arg Leu Pro Lys Ala His Pro Leu Phe 
            260                 265                 270         


Gln Lys Arg Arg Leu Leu Glu Glu Ile Asn Ala Leu Met Ile Val Arg 
        275                 280                 285             


Pro Gly Glu Ile Ala Gln Arg Leu Thr Pro Glu Glu Arg Asp Thr Leu 
    290                 295                 300                 


Tyr Leu Lys Leu Lys Asp Lys Arg Thr Val Ser Phe Ala Thr Leu Arg 
305                 310                 315                 320 


Lys Thr Leu Lys Leu Asp Ser Ala Ala Arg Phe Asn Lys Glu Ser Glu 
                325                 330                 335     


Asn Arg Thr Glu Leu Lys Gly Asp Glu Val Ala Ala Glu Leu Gly Ala 
            340                 345                 350         


Lys Thr Arg Leu Gly Thr Arg Trp Gln His Leu Ser Gly Asp Gln Gln 
        355                 360                 365             


Trp Glu Val Val His Arg Leu Met Ala Leu Glu Ser Gln Ala Asp Glu 
    370                 375                 380                 


Ala Ala Phe Arg Asp Trp Ile Ser Gln Thr Tyr Asp Leu Leu Pro Glu 
385                 390                 395                 400 


Gln Ala Ala Ala Val Leu Gly Ala Arg Leu Pro Gln Gly His Gly Arg 
                405                 410                 415     


Phe Gly Pro Thr Ala Thr Thr Thr Leu Ile Asp Ser Leu Leu His Asp 
            420                 425                 430         


Arg Thr Glu Asp Gly Arg Val Val Val Tyr Ser Glu Ala Val Gln Arg 
        435                 440                 445             


Ser Gly Leu Gly His His Ser Asp Leu Arg His Asp Arg Asp Asp Glu 
    450                 455                 460                 


Asp Val Thr Glu Leu Pro Tyr Tyr Gly Val Ala Leu Glu Arg His Ile 
465                 470                 475                 480 


Met Pro Gly Thr Ala Glu Pro Thr Asp Pro Glu Glu Met Arg Ile Gly 
                485                 490                 495     


Arg Leu Thr Asn Pro Thr Val His Ile Gly Leu Asn Gln Leu Arg His 
            500                 505                 510         


Val Val Asn Arg Leu Ile Arg Ala Tyr Gly Pro Pro Lys Glu Ile Ala 
        515                 520                 525             


Ile Glu Leu Ala Arg Glu Leu Lys Leu Ser Glu Asp Glu Lys Lys Lys 
    530                 535                 540                 


Arg Asn Ser Glu Asn Arg Asp Asn Arg Leu Ala Ala Glu Gly Arg Ser 
545                 550                 555                 560 


Lys Lys Leu Glu Glu Ile Arg Gln Arg Asp Thr Gly Ala Asn Arg Ala 
                565                 570                 575     


Leu Leu Lys Leu Trp Glu Glu Leu Asn Pro Gly Asn Val Leu Asp Arg 
            580                 585                 590         


Arg Cys Ile Tyr Thr Gly Glu Gln Ile Ser Ile Asp Met Leu Phe Ser 
        595                 600                 605             


Asp Arg Val Glu Val Asp His Ile Leu Pro Phe Ala Gln Thr Leu Asp 
    610                 615                 620                 


Asp Ser Asn Gly Asn Lys Leu Leu Cys Leu Arg Glu Ala Asn Arg Glu 
625                 630                 635                 640 


Lys Arg Arg Arg Ser Pro Tyr Glu Ala Trp Gly His Thr Asp Arg Trp 
                645                 650                 655     


Pro Asp Ile Ala Glu Arg Ala Ser Arg Leu Pro Lys Pro Lys Arg Trp 
            660                 665                 670         


Arg Phe Glu Pro Asp Ala Met Gln Arg Phe Ala Thr Glu Asp Gly Phe 
        675                 680                 685             


Leu Ala Arg His Leu Val Asp Thr Gln Tyr Leu Gly Arg Leu Ala Arg 
    690                 695                 700                 


Glu Tyr Leu Ser Trp Leu Tyr Pro Gly Arg Gly Glu Gly Ser Gly His 
705                 710                 715                 720 


Val Trp Val Ser Pro Gly Arg Leu Thr Glu Met Val Arg Arg Lys Leu 
                725                 730                 735     


Gly Leu Asn Asp Leu Leu Pro Asp His Asn Phe Gly Gly Gly Ala Asp 
            740                 745                 750         


Gln Pro Lys Asn Arg Leu Asp His Arg His His Ala Ile Asp Ala Leu 
        755                 760                 765             


Val Val Ala Ile Val Asp Arg Gly Met Leu Gln Ala Ile Ala Arg Ala 
    770                 775                 780                 


Ser Gly Gln Asp Gly Ser Glu Gly Arg Glu Arg Ile His Ile Pro Ala 
785                 790                 795                 800 


Pro Trp Asp Gly Phe Arg Asp Asp Leu Arg Val Ala Val Asn Gly Ile 
                805                 810                 815     


Ile Val Ser His Arg Pro Asp His Gly Thr Val Ala Lys Ala Gly Leu 
            820                 825                 830         


Ala Arg Gly Arg Asp Gln Thr Ala Gly Arg Leu His Asn Asp Thr Ala 
        835                 840                 845             


Tyr Gly Leu Thr Gly Glu Thr Asp Ala Lys Gly Asn Ser Ile Val Val 
    850                 855                 860                 


Arg Arg Ile Pro Leu Ser Ala Ile Lys Lys Pro Ala Asp Ile Ala Arg 
865                 870                 875                 880 


Val Arg Asp Pro Leu Leu Arg Asn Ala Leu Ala Glu Phe Thr Lys Gly 
                885                 890                 895     


Leu Asp Gly Lys Ala Phe Glu Ala Arg Ile Gly Arg Phe His Glu Leu 
            900                 905                 910         


Gly Pro Leu Leu Tyr Arg Gly Ile Arg Arg Val Arg Val Val Glu Thr 
        915                 920                 925             


Leu Thr Val Ile Pro Ile Arg Asp Ala Glu Gly Arg Ala Tyr Lys Gly 
    930                 935                 940                 


Tyr Lys Gly Asp Ser Asn Tyr Arg Tyr Asp Val Trp Glu Met Pro Asp 
945                 950                 955                 960 


Gly Lys Trp Arg Cys Gln Val Val Ser Met Phe Asp Ala His Gln Ser 
                965                 970                 975     


Thr Glu Gln Ala Arg Pro His Pro Ala Ala Arg Lys Ile Leu Ser Leu 
            980                 985                 990         


Gln Arg Asn Asp Ile Leu Ala Ile  Glu Arg Thr Glu Gly  Asp Arg Glu 
        995                 1000                 1005             


Leu Val  Arg Val Val Lys Phe  Ser Glu Lys Gln Phe  Ala Val Ala 
    1010                 1015                 1020             


Pro Pro  His Glu Gly Gly Ser  Leu Lys Thr Arg Asp  Gly Asn Ala 
    1025                 1030                 1035             


Asp Asp  Pro Phe Arg Tyr Leu  Tyr Pro Ser Pro Asn  Thr Leu Lys 
    1040                 1045                 1050             


Gly Trp  Arg Ala Arg Gln Val  Arg Ile Asp Glu Leu  Gly Arg Val 
    1055                 1060                 1065             


Leu Asp  Pro Gly Phe Pro Ala  Arg Lys Ser Val Arg  Arg Thr Arg 
    1070                 1075                 1080             


Pro Arg  Ala Ala Pro Val Asp  
    1085                 1090 


<210> 426
<211> 1084
<212> PRT
<213> Sporolactobacillus vineae


<220>
<223> Sporolactobacillus vineae DSM 21990 = SL153

<400> 426
Met Lys Tyr Ser Ile Gly Leu Asp Ile Gly Ile Ser Ser Val Gly Trp 
1               5                   10                  15      


Ser Val Ile Asn Leu Asp Arg Glu Arg Ile Glu Leu Met Gly Ala Arg 
            20                  25                  30          


Leu Phe Asp Ala Ala Glu Asn Pro Lys Asn Gly Ser Ser Leu Ala Ala 
        35                  40                  45              


Pro Arg Arg Asp Ala Arg Ser Ala Arg Arg Arg Leu Arg Arg Arg Arg 
    50                  55                  60                  


Tyr Arg Val Gly Arg Val Arg His Phe Ile Ile Asp Arg Gly Leu Val 
65                  70                  75                  80  


Thr Arg Gly Gln Ala Asp Gln Leu Phe Asp Trp Lys Asp Gly Asp Leu 
                85                  90                  95      


Asp Ile Trp Leu Val Arg Val Asn Ala Leu Glu Arg Leu Leu Thr Asp 
            100                 105                 110         


Arg Glu Phe Ala Arg Val Leu Ile His Ile Ala Lys Asn Arg Gly Tyr 
        115                 120                 125             


Arg Ser Asn Arg Lys Ser Glu Ala Lys Ser Gly Glu Asn Gly Gln Val 
    130                 135                 140                 


Leu Ser Ala Ile Lys Ala Asn Lys Glu Leu Met Glu Glu Lys Gly Tyr 
145                 150                 155                 160 


Gln Thr Val Ala Glu Met Leu Val Asn Glu Pro Glu Thr Phe Ala Gly 
                165                 170                 175     


Arg Lys Arg Asn Arg Gly Gly Glu Tyr Thr His Val Ile Ala Arg Ser 
            180                 185                 190         


Glu Leu Glu His Glu Ile Arg Leu Ile Phe Thr Lys Gln Arg Ala Phe 
        195                 200                 205             


Gly Asn Arg Phe Ala Thr Glu Glu Asn Glu Asn Thr Tyr Val Lys Ile 
    210                 215                 220                 


Trp Ala Ala Gln Arg Pro Val Ala Thr Lys Asp Asp Ile Leu Lys Lys 
225                 230                 235                 240 


Ile Gly Asp Cys Thr Phe Glu Lys Gly Glu Lys Arg Ala Pro Lys Ala 
                245                 250                 255     


Ser Tyr Ala Phe Gln Tyr Phe Arg Ala Leu Asp Lys Leu Asn Arg Leu 
            260                 265                 270         


Arg Ile Leu Ser Val Arg Glu Pro Ser Arg Asn Leu Thr Asp Asp Glu 
        275                 280                 285             


Arg Asn Leu Ile Val Pro Ala Leu Phe Asn His Asp Lys Gln Lys Tyr 
    290                 295                 300                 


Ser Asp Leu Arg Lys Ile Leu Gln Leu Arg Asp Asp Gln Lys Phe Asn 
305                 310                 315                 320 


Glu Leu Phe Tyr Asp Pro Gly Lys Ser Leu Lys Glu Asn Glu Asn Lys 
                325                 330                 335     


Thr Phe Leu Ser Leu Ala Glu Gln Tyr Lys Ile Arg Lys Val Ile Arg 
            340                 345                 350         


Asp Val Gln Gly Lys Asp Gly Leu Leu Gln Tyr Arg Pro Leu Asp Ile 
        355                 360                 365             


Asp Thr Ile Ala Tyr Ala Leu Thr Val Phe Lys Asp Asp Gln Asp Thr 
    370                 375                 380                 


Arg Asp Tyr Leu Ser Asn Thr Phe Val Asn Gly Asn Gly Lys Gln Val 
385                 390                 395                 400 


Leu Asn Leu Ala Asn Arg Ala Phe Asp Ala Glu Leu Ile Asp Gly Leu 
                405                 410                 415     


Leu Ser Leu Ser Phe Ala Lys Phe Gly His Leu Ser Leu Lys Ala Leu 
            420                 425                 430         


His Lys Leu Ile Pro His Met Glu Gln Gly Leu Ser Tyr Tyr Asp Ala 
        435                 440                 445             


Cys Lys Lys Val Gly Tyr His Asp Asn Glu Gln Val Gly Lys Ser Lys 
    450                 455                 460                 


Gln His Leu Leu Pro Val Ile Pro Ala Asp Glu Ile Arg Asn Pro Val 
465                 470                 475                 480 


Val Val Arg Ser Leu Ser Gln Thr Arg Lys Val Ile Asn Ala Ile Ile 
                485                 490                 495     


Lys Arg Tyr Gly Ser Pro Thr Phe Met Tyr Ile Glu Leu Ala Arg Glu 
            500                 505                 510         


Met Gly Arg Pro Tyr Asn Glu Arg Arg Asp Leu Glu Lys Gln Tyr Asn 
        515                 520                 525             


Lys Asn Arg Thr Val Asn Asp Ser Ala Ile Glu Gln Ile His Glu Leu 
    530                 535                 540                 


Tyr Pro Glu Ile Gly Ala Pro Arg Gly His Asp Ile Leu Lys Tyr Lys 
545                 550                 555                 560 


Leu Trp Gln Gln Gln Asp Cys Lys Cys Ala Tyr Ser Leu Glu Lys Ile 
                565                 570                 575     


Pro Ala Glu Lys Ile Phe Glu Pro Gly Tyr Ala Glu Val Asp His Ile 
            580                 585                 590         


Ile Pro Tyr Ser Arg Ser Phe Asp Asp Ser Asn Ser Asn Lys Val Leu 
        595                 600                 605             


Val Leu Ser Arg Met Asn Gln Glu Lys Lys Asn Arg Thr Pro Tyr Glu 
    610                 615                 620                 


Trp Phe Gly Gly Asp Glu His Arg Trp Asn Lys Phe Glu Ser Tyr Val 
625                 630                 635                 640 


Asn Ala Leu Lys Val Asn Arg Lys Lys Lys Ser Leu Leu Thr Lys Lys 
                645                 650                 655     


Asn Met Asp Thr Glu Glu Glu Asp Thr Phe Lys Ser Arg His Leu Asn 
            660                 665                 670         


Asp Thr Arg Tyr Ile Thr Arg Phe Ile Lys Ser Phe Val Glu Asp Asn 
        675                 680                 685             


Leu Leu Phe Arg Glu Ile Glu Gly Ala Lys Gln His Val Phe Thr Val 
    690                 695                 700                 


Asn Gly Ala Tyr Thr Ser Leu Met Arg Lys Arg Trp Gly Phe Asn Lys 
705                 710                 715                 720 


Asn Arg Glu Glu Ser Asp Leu His His Ser Val Asp Ala Val Ile Ile 
                725                 730                 735     


Ala Val Ser Gln Pro Phe Arg Asn Glu Val Ser Arg Tyr Phe Lys His 
            740                 745                 750         


Arg Glu Ile Ser Leu Pro Gln Leu Leu Lys Arg Thr Trp Asp Tyr Phe 
        755                 760                 765             


Pro Glu Pro Trp Glu Gly Phe Val Lys Glu Leu Arg Ala Arg Thr Leu 
    770                 775                 780                 


Gln Asp Pro Glu Lys Leu Lys Leu Ala Leu Glu Ser Leu Asp Leu Asp 
785                 790                 795                 800 


Ser Tyr Asp Pro Glu Phe Ile Asp Glu Val Lys Pro Ile Phe Ile Ser 
                805                 810                 815     


Arg Met Pro Lys Arg Ser Ile Lys Gly Gln Ile His Asp Glu Thr Leu 
            820                 825                 830         


Arg Arg Asn Arg Gly Lys Thr Lys Asp Gly Phe Val Lys Ile Val Thr 
        835                 840                 845             


Arg Thr Arg Leu Glu Asn Ile Lys Phe Asp Lys Asn Gly Asp Phe Pro 
    850                 855                 860                 


Met Tyr Gly Arg Glu Ser Asp Pro Lys Thr Tyr Gln Ala Ile Lys Gln 
865                 870                 875                 880 


Arg Tyr Leu Glu Asn Asn Lys Asp Lys Lys Lys Ala Phe Ile Glu Pro 
                885                 890                 895     


Leu Tyr Lys Pro Ala Lys Asn Pro Asn Asn Ala Ser Leu Ile Arg Ser 
            900                 905                 910         


Val Lys Ile Glu Asp Lys Ala Asn Gln Ile Val Pro Leu Arg Asp Glu 
        915                 920                 925             


Ala Val Ala Tyr Asn Ala Ser Ile Val Arg Thr Glu Val Tyr Arg Asn 
    930                 935                 940                 


Lys Glu Thr Gly Lys Phe Tyr Leu Ala Pro Val Tyr Val Ser Asp Val 
945                 950                 955                 960 


Phe Ala Gly Arg Glu Pro Arg Arg Phe Ile Arg Ala Asn Val Pro Tyr 
                965                 970                 975     


Glu Gln Trp Val Asn Ile Thr Asp Lys Phe Thr Phe Leu Phe Asn Leu 
            980                 985                 990         


Tyr Pro Asn Asp Val Ile Tyr Ile  Lys Met Lys Lys Val  Lys Thr Thr 
        995                 1000                 1005             


Lys Ser  Asn Ile Asn Lys Thr  Ile Ser Trp Gln Glu  Ser Tyr Phe 
    1010                 1015                 1020             


Tyr Phe  Lys Gly Thr Asp Ile  His Thr Gly Ala Ile  Thr Ile Ile 
    1025                 1030                 1035             


Asp His  Met Asn Ser Phe Thr  Asp Arg Val Gly Thr  Gln Gly Leu 
    1040                 1045                 1050             


Gln Leu  Phe Glu Lys Tyr Gln  Val Asp Pro Leu Gly  Asn Leu Ser 
    1055                 1060                 1065             


Arg Val  His Gly Glu Thr Gln  Tyr Gly Val Pro Ala  Leu Ser His 
    1070                 1075                 1080             


Ser 
    


<210> 427
<211> 1053
<212> PRT
<213> Staphylococcus aureus


<220>
<223> Staphylococcus aureus subsp. aureus

<400> 427
Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210> 428
<211> 1054
<212> PRT
<213> Staphylococcus lugdunensis


<220>
<223> Staphylococcus lugdunensis M23590

<400> 428
Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Glu Arg Val Lys Lys Leu Leu Glu Asp Tyr Asn Leu Leu Asp Gln Ser 
65                  70                  75                  80  


Gln Ile Pro Gln Ser Thr Asn Pro Tyr Ala Ile Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Glu Ala Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile 
            100                 105                 110         


Ala Lys Arg Arg Gly Ile His Lys Ile Asp Val Ile Asp Ser Asn Asp 
        115                 120                 125             


Asp Val Gly Asn Glu Leu Ser Thr Lys Glu Gln Leu Asn Lys Asn Ser 
    130                 135                 140                 


Lys Leu Leu Lys Asp Lys Phe Val Cys Gln Ile Gln Leu Glu Arg Met 
145                 150                 155                 160 


Asn Glu Gly Gln Val Arg Gly Glu Lys Asn Arg Phe Lys Thr Ala Asp 
                165                 170                 175     


Ile Ile Lys Glu Ile Ile Gln Leu Leu Asn Val Gln Lys Asn Phe His 
            180                 185                 190         


Gln Leu Asp Glu Asn Phe Ile Asn Lys Tyr Ile Glu Leu Val Glu Met 
        195                 200                 205             


Arg Arg Glu Tyr Phe Glu Gly Pro Gly Lys Gly Ser Pro Tyr Gly Trp 
    210                 215                 220                 


Glu Gly Asp Pro Lys Ala Trp Tyr Glu Thr Leu Met Gly His Cys Thr 
225                 230                 235                 240 


Tyr Phe Pro Asp Glu Leu Arg Ser Val Lys Tyr Ala Tyr Ser Ala Asp 
                245                 250                 255     


Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Gln Arg Asp 
            260                 265                 270         


Gly Leu Ser Lys Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn 
        275                 280                 285             


Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Asn Glu 
    290                 295                 300                 


Ile Asn Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile Thr Lys Ser 
305                 310                 315                 320 


Gly Lys Pro Gln Phe Thr Glu Phe Lys Leu Tyr His Asp Leu Lys Ser 
                325                 330                 335     


Val Leu Phe Asp Gln Ser Ile Leu Glu Asn Glu Asp Val Leu Asp Gln 
            340                 345                 350         


Ile Ala Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser Ile Lys Ser 
        355                 360                 365             


Lys Leu Thr Glu Leu Asp Ile Leu Leu Asn Glu Glu Asp Lys Glu Asn 
    370                 375                 380                 


Ile Ala Gln Leu Thr Gly Tyr Thr Gly Thr His Arg Leu Ser Leu Lys 
385                 390                 395                 400 


Cys Ile Arg Leu Val Leu Glu Glu Gln Trp Tyr Ser Ser Arg Asn Gln 
                405                 410                 415     


Met Glu Ile Phe Thr His Leu Asn Ile Lys Pro Lys Lys Ile Asn Leu 
            420                 425                 430         


Thr Ala Ala Asn Lys Ile Pro Lys Ala Met Ile Asp Glu Phe Ile Leu 
        435                 440                 445             


Ser Pro Val Val Lys Arg Thr Phe Gly Gln Ala Ile Asn Leu Ile Asn 
    450                 455                 460                 


Lys Ile Ile Glu Lys Tyr Gly Val Pro Glu Asp Ile Ile Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Asn Asn Ser Lys Asp Lys Gln Lys Phe Ile Asn Glu Met 
                485                 490                 495     


Gln Lys Lys Asn Glu Asn Thr Arg Lys Arg Ile Asn Glu Ile Ile Gly 
            500                 505                 510         


Lys Tyr Gly Asn Gln Asn Ala Lys Arg Leu Val Glu Lys Ile Arg Leu 
        515                 520                 525             


His Asp Glu Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ser Ile Pro 
    530                 535                 540                 


Leu Glu Asp Leu Leu Asn Asn Pro Asn His Tyr Glu Val Asp His Ile 
545                 550                 555                 560 


Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Tyr His Asn Lys Val Leu 
                565                 570                 575     


Val Lys Gln Ser Glu Asn Ser Lys Lys Ser Asn Leu Thr Pro Tyr Gln 
            580                 585                 590         


Tyr Phe Asn Ser Gly Lys Ser Lys Leu Ser Tyr Asn Gln Phe Lys Gln 
        595                 600                 605             


His Ile Leu Asn Leu Ser Lys Ser Gln Asp Arg Ile Ser Lys Lys Lys 
    610                 615                 620                 


Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe Glu Val Gln 
625                 630                 635                 640 


Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg 
                645                 650                 655     


Glu Leu Thr Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn Asn Met Asn 
            660                 665                 670         


Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr Leu Arg Lys 
        675                 680                 685             


Val Trp Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys His His Ala 
    690                 695                 700                 


Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys Glu Asn 
705                 710                 715                 720 


Lys Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro Glu Ile Glu 
                725                 730                 735     


Ser Lys Gln Leu Asp Ile Gln Val Asp Ser Glu Asp Asn Tyr Ser Glu 
            740                 745                 750         


Met Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp Phe Arg Asn 
        755                 760                 765             


Phe Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser Thr Tyr Ile 
785                 790                 795                 800 


Val Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr Thr Leu Lys 
                805                 810                 815     


Lys Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr Gln His Asp 
            820                 825                 830         


Pro Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln Tyr Ala Asn 
        835                 840                 845             


Glu Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly Glu Tyr Leu 
    850                 855                 860                 


Thr Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys Ser Leu Lys 
865                 870                 875                 880 


Tyr Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr His Gln Phe 
                885                 890                 895     


Lys Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys Pro Tyr Arg 
            900                 905                 910         


Phe Asp Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile Thr Ile Ser 
        915                 920                 925             


Tyr Leu Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile Pro Glu Gln 
    930                 935                 940                 


Lys Tyr Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys Asn Ala Lys 
945                 950                 955                 960 


Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu Asp Gly Glu 
                965                 970                 975     


Ile Tyr Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn Met Ile Glu 
            980                 985                 990         


Leu Asp Leu Pro Asp Ile Arg Tyr  Lys Glu Tyr Cys Glu  Leu Asn Asn 
        995                 1000                 1005             


Ile Lys  Gly Glu Pro Arg Ile  Lys Lys Thr Ile Gly  Lys Lys Val 
    1010                 1015                 1020             


Asn Ser  Ile Glu Lys Leu Thr  Thr Asp Val Leu Gly  Asn Val Phe 
    1025                 1030                 1035             


Thr Asn  Thr Gln Tyr Thr Lys  Pro Gln Leu Leu Phe  Lys Arg Gly 
    1040                 1045                 1050             


Asn 
    


<210> 429
<211> 1334
<212> PRT
<213> Staphylococcus pseudintermedius

<400> 429
Met Gly Arg Lys Pro Tyr Ile Leu Ser Leu Asp Ile Gly Thr Gly Ser 
1               5                   10                  15      


Val Gly Tyr Ala Cys Met Asp Lys Gly Phe Asn Val Leu Lys Tyr His 
            20                  25                  30          


Asp Lys Asp Ala Leu Gly Val Tyr Leu Phe Asp Gly Ala Leu Thr Ala 
        35                  40                  45              


Gln Glu Arg Arg Gln Phe Arg Thr Ser Arg Arg Arg Lys Asn Arg Arg 
    50                  55                  60                  


Ile Lys Arg Leu Gly Leu Leu Gln Glu Leu Leu Ala Pro Leu Val Gln 
65                  70                  75                  80  


Asn Pro Asn Phe Tyr Gln Phe Gln Arg Gln Phe Ala Trp Lys Asn Asp 
                85                  90                  95      


Asn Met Asp Phe Lys Asn Lys Ser Leu Ser Glu Val Leu Ser Phe Leu 
            100                 105                 110         


Gly Tyr Glu Ser Lys Lys Tyr Pro Thr Ile Tyr His Leu Gln Glu Ala 
        115                 120                 125             


Leu Leu Leu Lys Asp Glu Lys Phe Asp Pro Glu Leu Ile Tyr Met Ala 
    130                 135                 140                 


Leu Tyr His Leu Val Lys Tyr Arg Gly His Phe Leu Phe Asp His Leu 
145                 150                 155                 160 


Lys Ile Glu Asn Leu Thr Asn Asn Asp Asn Met His Asp Phe Val Glu 
                165                 170                 175     


Leu Ile Glu Thr Tyr Glu Asn Leu Asn Asn Ile Lys Leu Asn Leu Asp 
            180                 185                 190         


Tyr Glu Lys Thr Lys Val Ile Tyr Glu Ile Leu Lys Asp Asn Glu Met 
        195                 200                 205             


Thr Lys Asn Asp Arg Ala Lys Arg Val Lys Asn Met Glu Lys Lys Leu 
    210                 215                 220                 


Glu Gln Phe Ser Ile Met Leu Leu Gly Leu Lys Phe Asn Glu Gly Lys 
225                 230                 235                 240 


Leu Phe Asn His Ala Asp Asn Ala Glu Glu Leu Lys Gly Ala Asn Gln 
                245                 250                 255     


Ser His Thr Phe Ala Asp Asn Tyr Glu Glu Asn Leu Thr Pro Phe Leu 
            260                 265                 270         


Thr Val Glu Gln Ser Glu Phe Ile Glu Arg Ala Asn Lys Ile Tyr Leu 
        275                 280                 285             


Ser Leu Thr Leu Gln Asp Ile Leu Lys Gly Lys Lys Ser Met Ala Met 
    290                 295                 300                 


Ser Lys Val Ala Ala Tyr Asp Lys Phe Arg Asn Glu Leu Lys Gln Val 
305                 310                 315                 320 


Lys Asp Ile Val Tyr Lys Ala Asp Ser Thr Arg Thr Gln Phe Lys Lys 
                325                 330                 335     


Ile Phe Val Ser Ser Lys Lys Ser Leu Lys Gln Tyr Asp Ala Thr Pro 
            340                 345                 350         


Asn Asp Gln Thr Phe Ser Ser Leu Cys Leu Phe Asp Gln Tyr Leu Ile 
        355                 360                 365             


Arg Pro Lys Lys Gln Tyr Ser Leu Leu Ile Lys Glu Leu Lys Lys Ile 
    370                 375                 380                 


Ile Pro Gln Asp Ser Glu Leu Tyr Phe Glu Ala Glu Asn Asp Thr Leu 
385                 390                 395                 400 


Leu Lys Val Leu Asn Thr Thr Asp Asn Ala Ser Ile Pro Met Gln Ile 
                405                 410                 415     


Asn Leu Tyr Glu Ala Glu Thr Ile Leu Arg Asn Gln Gln Lys Tyr His 
            420                 425                 430         


Ala Glu Ile Thr Asp Glu Met Ile Glu Lys Val Leu Ser Leu Ile Gln 
        435                 440                 445             


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Asn Asp His Thr Ala 
    450                 455                 460                 


Ser Lys Phe Gly Trp Met Glu Arg Lys Ser Asn Glu Ser Ile Lys Pro 
465                 470                 475                 480 


Trp Asn Phe Asp Glu Val Val Asp Arg Ser Lys Ser Ala Thr Gln Phe 
                485                 490                 495     


Ile Arg Arg Met Thr Asn Lys Cys Ser Tyr Leu Ile Asn Glu Asp Val 
            500                 505                 510         


Leu Pro Lys Asn Ser Leu Leu Tyr Gln Glu Met Glu Val Leu Asn Glu 
        515                 520                 525             


Leu Asn Ala Thr Gln Ile Arg Leu Gln Thr Asp Pro Lys Asn Arg Lys 
    530                 535                 540                 


Tyr Arg Met Met Pro Gln Ile Lys Leu Phe Ala Val Glu His Ile Phe 
545                 550                 555                 560 


Lys Lys Tyr Lys Thr Val Ser His Ser Lys Phe Leu Glu Ile Met Leu 
                565                 570                 575     


Asn Ser Asn His Arg Glu Asn Phe Met Asn His Gly Glu Lys Leu Ser 
            580                 585                 590         


Ile Phe Gly Thr Gln Asp Asp Lys Lys Phe Ala Ser Lys Leu Ser Ser 
        595                 600                 605             


Tyr Gln Asp Met Thr Lys Ile Phe Gly Asp Ile Glu Gly Lys Arg Ala 
    610                 615                 620                 


Gln Ile Glu Glu Ile Ile Gln Trp Ile Thr Ile Phe Glu Asp Lys Lys 
625                 630                 635                 640 


Ile Leu Val Gln Lys Leu Lys Glu Cys Tyr Pro Glu Leu Thr Ser Lys 
                645                 650                 655     


Gln Ile Asn Gln Leu Lys Lys Leu Asn Tyr Ser Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Glu Lys Leu Leu Thr His Ala Tyr Gln Gly His Ser Ile Ile Glu 
        675                 680                 685             


Leu Leu Arg His Ser Asp Glu Asn Phe Met Glu Ile Leu Thr Asn Asp 
    690                 695                 700                 


Val Tyr Gly Phe Gln Asn Phe Ile Lys Glu Glu Asn Gln Val Gln Ser 
705                 710                 715                 720 


Asn Lys Ile Gln His Gln Asp Ile Ala Asn Leu Thr Thr Ser Pro Ala 
                725                 730                 735     


Leu Lys Lys Gly Ile Trp Ser Thr Ile Lys Leu Val Arg Glu Leu Thr 
            740                 745                 750         


Ser Ile Phe Gly Glu Pro Glu Lys Ile Ile Met Glu Phe Ala Thr Glu 
        755                 760                 765             


Asp Gln Gln Lys Gly Lys Lys Gln Lys Ser Arg Lys Gln Leu Trp Asp 
    770                 775                 780                 


Asp Asn Ile Lys Lys Asn Lys Leu Lys Ser Val Asp Glu Tyr Lys Tyr 
785                 790                 795                 800 


Ile Ile Asp Val Ala Asn Lys Leu Asn Asn Glu Gln Leu Gln Gln Glu 
                805                 810                 815     


Lys Leu Trp Leu Tyr Leu Ser Gln Asn Gly Lys Cys Met Tyr Ser Gly 
            820                 825                 830         


Gln Ser Ile Asp Leu Asp Ala Leu Leu Ser Pro Asn Ala Thr Lys His 
        835                 840                 845             


Tyr Glu Val Asp His Ile Phe Pro Arg Ser Phe Ile Lys Asp Asp Ser 
    850                 855                 860                 


Ile Asp Asn Lys Val Leu Val Ile Lys Lys Met Asn Gln Thr Lys Gly 
865                 870                 875                 880 


Asp Gln Val Pro Leu Gln Phe Ile Gln Gln Pro Tyr Glu Arg Ile Ala 
                885                 890                 895     


Tyr Trp Lys Ser Leu Asn Lys Ala Gly Leu Ile Ser Asp Ser Lys Leu 
            900                 905                 910         


His Lys Leu Met Lys Pro Glu Phe Thr Ala Met Asp Lys Glu Gly Phe 
        915                 920                 925             


Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Ser Val His Val Arg 
    930                 935                 940                 


Asp Phe Leu Lys Glu Glu Tyr Pro Asn Thr Lys Val Ile Pro Met Lys 
945                 950                 955                 960 


Ala Lys Met Val Ser Glu Phe Arg Lys Lys Phe Asp Ile Pro Lys Ile 
                965                 970                 975     


Arg Gln Met Asn Asp Ala His His Ala Ile Asp Ala Tyr Leu Asn Gly 
            980                 985                 990         


Val Val Tyr His Gly Ala Gln Leu  Ala Tyr Pro Asn Val  Asp Leu Phe 
        995                 1000                 1005             


Asp Phe  Asn Phe Lys Trp Glu  Lys Val Arg Glu Lys  Trp Lys Ala 
    1010                 1015                 1020             


Leu Gly  Glu Phe Asn Thr Lys  Gln Lys Ser Arg Glu  Leu Phe Phe 
    1025                 1030                 1035             


Phe Lys  Lys Leu Glu Lys Met  Glu Val Ser Gln Gly  Glu Arg Leu 
    1040                 1045                 1050             


Ile Ser  Lys Ile Lys Leu Asp  Met Asn His Phe Lys  Ile Asn Tyr 
    1055                 1060                 1065             


Ser Arg  Lys Leu Ala Asn Ile  Pro Gln Gln Phe Tyr  Asn Gln Thr 
    1070                 1075                 1080             


Ala Val  Ser Pro Lys Thr Ala  Glu Leu Lys Tyr Glu  Ser Asn Lys 
    1085                 1090                 1095             


Ser Asn  Glu Val Val Tyr Lys  Gly Leu Thr Pro Tyr  Gln Thr Tyr 
    1100                 1105                 1110             


Val Val  Ala Ile Lys Ser Val  Asn Lys Lys Gly Lys  Glu Lys Met 
    1115                 1120                 1125             


Glu Tyr  Gln Met Ile Asp His  Tyr Val Phe Asp Phe  Tyr Lys Phe 
    1130                 1135                 1140             


Gln Asn  Gly Asn Glu Lys Glu  Leu Ala Leu Tyr Leu  Ala Gln Arg 
    1145                 1150                 1155             


Glu Asn  Lys Asp Glu Val Leu  Asp Ala Gln Ile Val  Tyr Ser Leu 
    1160                 1165                 1170             


Asn Lys  Gly Asp Leu Leu Tyr  Ile Asn Asn His Pro  Cys Tyr Phe 
    1175                 1180                 1185             


Val Ser  Arg Lys Glu Val Ile  Asn Ala Lys Gln Phe  Glu Leu Thr 
    1190                 1195                 1200             


Val Glu  Gln Gln Leu Ser Leu  Tyr Asn Val Met Asn  Asn Lys Glu 
    1205                 1210                 1215             


Thr Asn  Val Glu Lys Leu Leu  Ile Glu Tyr Asp Phe  Ile Ala Glu 
    1220                 1225                 1230             


Lys Val  Ile Asn Glu Tyr His  His Tyr Leu Asn Ser  Lys Leu Lys 
    1235                 1240                 1245             


Glu Lys  Arg Val Arg Thr Phe  Phe Ser Glu Ser Asn  Gln Thr His 
    1250                 1255                 1260             


Glu Asp  Phe Ile Lys Ala Leu  Asp Glu Leu Phe Lys  Val Val Thr 
    1265                 1270                 1275             


Ala Ser  Ala Thr Arg Ser Asp  Lys Ile Gly Ser Arg  Lys Asn Ser 
    1280                 1285                 1290             


Met Thr  His Arg Ala Phe Leu  Gly Lys Gly Lys Asp  Val Lys Ile 
    1295                 1300                 1305             


Ala Tyr  Thr Ser Ile Ser Gly  Leu Lys Thr Thr Lys  Pro Lys Ser 
    1310                 1315                 1320             


Leu Phe  Lys Leu Ala Glu Ser  Arg Asn Glu Leu 
    1325                 1330                 


<210> 430
<211> 1334
<212> PRT
<213> Staphylococcus pseudintermedius


<220>
<223> Staphylococcus pseudintermedius ED99

<400> 430
Met Gly Arg Lys Pro Tyr Ile Leu Ser Leu Asp Ile Gly Thr Gly Ser 
1               5                   10                  15      


Val Gly Tyr Ala Cys Met Asp Lys Gly Phe Asn Val Leu Lys Tyr His 
            20                  25                  30          


Asp Lys Asp Ala Leu Gly Val Tyr Leu Phe Asp Gly Ala Leu Thr Ala 
        35                  40                  45              


Gln Glu Arg Arg Gln Phe Arg Thr Ser Arg Arg Arg Lys Asn Arg Arg 
    50                  55                  60                  


Ile Lys Arg Leu Gly Leu Leu Gln Glu Leu Leu Ala Pro Leu Val Gln 
65                  70                  75                  80  


Asn Pro Asn Phe Tyr Gln Phe Gln Arg Gln Phe Ala Trp Lys Asn Asp 
                85                  90                  95      


Asn Met Asp Phe Lys Asn Lys Ser Leu Ser Glu Val Leu Ser Phe Leu 
            100                 105                 110         


Gly Tyr Glu Ser Lys Lys Tyr Pro Thr Ile Tyr His Leu Gln Glu Ala 
        115                 120                 125             


Leu Leu Leu Lys Asp Glu Lys Phe Asp Pro Glu Leu Ile Tyr Met Ala 
    130                 135                 140                 


Leu Tyr His Leu Val Lys Tyr Arg Gly His Phe Leu Phe Asp His Leu 
145                 150                 155                 160 


Lys Ile Glu Asn Leu Thr Asn Asn Asp Asn Met His Asp Phe Val Glu 
                165                 170                 175     


Leu Ile Glu Thr Tyr Glu Asn Leu Asn Asn Ile Lys Leu Asn Leu Asp 
            180                 185                 190         


Tyr Glu Lys Thr Lys Val Ile Tyr Glu Ile Leu Lys Asp Asn Glu Met 
        195                 200                 205             


Thr Lys Asn Asp Arg Ala Lys Arg Val Lys Asn Met Glu Lys Lys Leu 
    210                 215                 220                 


Glu Gln Phe Ser Ile Met Leu Leu Gly Leu Lys Phe Asn Glu Gly Lys 
225                 230                 235                 240 


Leu Phe Asn His Ala Asp Asn Ala Glu Glu Leu Lys Gly Ala Asn Gln 
                245                 250                 255     


Ser His Thr Phe Ala Asp Asn Tyr Glu Glu Asn Leu Thr Pro Phe Leu 
            260                 265                 270         


Thr Val Glu Gln Ser Glu Phe Ile Glu Arg Ala Asn Lys Ile Tyr Leu 
        275                 280                 285             


Ser Leu Thr Leu Gln Asp Ile Leu Lys Gly Lys Lys Ser Met Ala Met 
    290                 295                 300                 


Ser Lys Val Ala Ala Tyr Asp Lys Phe Arg Asn Glu Leu Lys Gln Val 
305                 310                 315                 320 


Lys Asp Ile Val Tyr Lys Ala Asp Ser Thr Arg Thr Gln Phe Lys Lys 
                325                 330                 335     


Ile Phe Val Ser Ser Lys Lys Ser Leu Lys Gln Tyr Asp Ala Thr Pro 
            340                 345                 350         


Asn Asp Gln Thr Phe Ser Ser Leu Cys Leu Phe Asp Gln Tyr Leu Ile 
        355                 360                 365             


Arg Pro Lys Lys Gln Tyr Ser Leu Leu Ile Lys Glu Leu Lys Lys Ile 
    370                 375                 380                 


Ile Pro Gln Asp Ser Glu Leu Tyr Phe Glu Ala Glu Asn Asp Thr Leu 
385                 390                 395                 400 


Leu Lys Val Leu Asn Thr Thr Asp Asn Ala Ser Ile Pro Met Gln Ile 
                405                 410                 415     


Asn Leu Tyr Glu Ala Glu Thr Ile Leu Arg Asn Gln Gln Lys Tyr His 
            420                 425                 430         


Ala Glu Ile Thr Asp Glu Met Ile Glu Lys Val Leu Ser Leu Ile Gln 
        435                 440                 445             


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Asn Asp His Thr Ala 
    450                 455                 460                 


Ser Lys Phe Gly Trp Met Glu Arg Lys Ser Asn Glu Ser Ile Lys Pro 
465                 470                 475                 480 


Trp Asn Phe Asp Glu Val Val Asp Arg Ser Lys Ser Ala Thr Gln Phe 
                485                 490                 495     


Ile Arg Arg Met Thr Asn Lys Cys Ser Tyr Leu Ile Asn Glu Asp Val 
            500                 505                 510         


Leu Pro Lys Asn Ser Leu Leu Tyr Gln Glu Met Glu Val Leu Asn Glu 
        515                 520                 525             


Leu Asn Ala Thr Gln Ile Arg Leu Gln Thr Asp Pro Lys Asn Arg Lys 
    530                 535                 540                 


Tyr Arg Met Met Pro Gln Ile Lys Leu Phe Ala Val Glu His Ile Phe 
545                 550                 555                 560 


Lys Lys Tyr Lys Thr Val Ser His Ser Lys Phe Leu Glu Ile Met Leu 
                565                 570                 575     


Asn Ser Asn His Arg Glu Asn Phe Met Asn His Gly Glu Lys Leu Ser 
            580                 585                 590         


Ile Phe Gly Thr Gln Asp Asp Lys Lys Phe Ala Ser Lys Leu Ser Ser 
        595                 600                 605             


Tyr Gln Asp Met Thr Lys Ile Phe Gly Asp Ile Glu Gly Lys Arg Ala 
    610                 615                 620                 


Gln Ile Glu Glu Ile Ile Gln Trp Ile Thr Ile Phe Glu Asp Lys Lys 
625                 630                 635                 640 


Ile Leu Val Gln Lys Leu Lys Glu Cys Tyr Pro Glu Leu Thr Ser Lys 
                645                 650                 655     


Gln Ile Asn Gln Leu Lys Lys Leu Asn Tyr Ser Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Glu Lys Leu Leu Thr His Ala Tyr Gln Gly His Ser Ile Ile Glu 
        675                 680                 685             


Leu Leu Arg His Ser Asp Glu Asn Phe Met Glu Ile Leu Thr Asn Asp 
    690                 695                 700                 


Val Tyr Gly Phe Gln Asn Phe Ile Lys Glu Glu Asn Gln Val Gln Ser 
705                 710                 715                 720 


Asn Lys Ile Gln His Gln Asp Ile Ala Asn Leu Thr Thr Ser Pro Ala 
                725                 730                 735     


Leu Lys Lys Gly Ile Trp Ser Thr Ile Lys Leu Val Arg Glu Leu Thr 
            740                 745                 750         


Ser Ile Phe Gly Glu Pro Glu Lys Ile Ile Met Glu Phe Ala Thr Glu 
        755                 760                 765             


Asp Gln Gln Lys Gly Lys Lys Gln Lys Ser Arg Lys Gln Leu Trp Asp 
    770                 775                 780                 


Asp Asn Ile Lys Lys Asn Lys Leu Lys Ser Val Asp Glu Tyr Lys Tyr 
785                 790                 795                 800 


Ile Ile Asp Val Ala Asn Lys Leu Asn Asn Glu Gln Leu Gln Gln Glu 
                805                 810                 815     


Lys Leu Trp Leu Tyr Leu Ser Gln Asn Gly Lys Cys Met Tyr Ser Gly 
            820                 825                 830         


Gln Ser Ile Asp Leu Asp Ala Leu Leu Ser Pro Asn Ala Thr Lys His 
        835                 840                 845             


Tyr Glu Val Asp His Ile Phe Pro Arg Ser Phe Ile Lys Asp Asp Ser 
    850                 855                 860                 


Ile Asp Asn Lys Val Leu Val Ile Lys Lys Met Asn Gln Thr Lys Gly 
865                 870                 875                 880 


Asp Gln Val Pro Leu Gln Phe Ile Gln Gln Pro Tyr Glu Arg Ile Ala 
                885                 890                 895     


Tyr Trp Lys Ser Leu Asn Lys Ala Gly Leu Ile Ser Asp Ser Lys Leu 
            900                 905                 910         


His Lys Leu Met Lys Pro Glu Phe Thr Ala Met Asp Lys Glu Gly Phe 
        915                 920                 925             


Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Ser Val His Val Arg 
    930                 935                 940                 


Asp Phe Leu Lys Glu Glu Tyr Pro Asn Thr Lys Val Ile Pro Met Lys 
945                 950                 955                 960 


Ala Lys Met Val Ser Glu Phe Arg Lys Lys Phe Asp Ile Pro Lys Ile 
                965                 970                 975     


Arg Gln Met Asn Asp Ala His His Ala Ile Asp Ala Tyr Leu Asn Gly 
            980                 985                 990         


Val Val Tyr His Gly Ala Gln Leu  Ala Tyr Pro Asn Val  Asp Leu Phe 
        995                 1000                 1005             


Asp Phe  Asn Phe Lys Trp Glu  Lys Val Arg Glu Lys  Trp Lys Ala 
    1010                 1015                 1020             


Leu Gly  Glu Phe Asn Thr Lys  Gln Lys Ser Arg Glu  Leu Phe Phe 
    1025                 1030                 1035             


Phe Lys  Lys Leu Glu Lys Met  Glu Val Ser Gln Gly  Glu Arg Leu 
    1040                 1045                 1050             


Ile Ser  Lys Ile Lys Leu Asp  Met Asn His Phe Lys  Ile Asn Tyr 
    1055                 1060                 1065             


Ser Arg  Lys Leu Ala Asn Ile  Pro Gln Gln Phe Tyr  Asn Gln Thr 
    1070                 1075                 1080             


Ala Val  Ser Pro Lys Thr Ala  Glu Leu Lys Tyr Glu  Ser Asn Lys 
    1085                 1090                 1095             


Ser Asn  Glu Val Val Tyr Lys  Gly Leu Thr Pro Tyr  Gln Thr Tyr 
    1100                 1105                 1110             


Val Val  Ala Ile Lys Ser Val  Asn Lys Lys Gly Lys  Glu Lys Met 
    1115                 1120                 1125             


Glu Tyr  Gln Met Ile Asp His  Tyr Val Phe Asp Phe  Tyr Lys Phe 
    1130                 1135                 1140             


Gln Asn  Gly Asn Glu Lys Glu  Leu Ala Leu Tyr Leu  Ala Gln Arg 
    1145                 1150                 1155             


Glu Asn  Lys Asp Glu Val Leu  Asp Ala Gln Ile Val  Tyr Ser Leu 
    1160                 1165                 1170             


Asn Lys  Gly Asp Leu Leu Tyr  Ile Asn Asn His Pro  Cys Tyr Phe 
    1175                 1180                 1185             


Val Ser  Arg Lys Glu Val Ile  Asn Ala Lys Gln Phe  Glu Leu Thr 
    1190                 1195                 1200             


Val Glu  Gln Gln Leu Ser Leu  Tyr Asn Val Met Asn  Asn Lys Glu 
    1205                 1210                 1215             


Thr Asn  Val Glu Lys Leu Leu  Ile Glu Tyr Asp Phe  Ile Ala Glu 
    1220                 1225                 1230             


Lys Val  Ile Asn Glu Tyr His  His Tyr Leu Asn Ser  Lys Leu Lys 
    1235                 1240                 1245             


Glu Lys  Arg Val Arg Thr Phe  Phe Ser Glu Ser Asn  Gln Thr His 
    1250                 1255                 1260             


Glu Asp  Phe Ile Lys Ala Leu  Asp Glu Leu Phe Lys  Val Val Thr 
    1265                 1270                 1275             


Ala Ser  Ala Thr Arg Ser Asp  Lys Ile Gly Ser Arg  Lys Asn Ser 
    1280                 1285                 1290             


Met Thr  His Arg Ala Phe Leu  Gly Lys Gly Lys Asp  Val Lys Ile 
    1295                 1300                 1305             


Ala Tyr  Thr Ser Ile Ser Gly  Leu Lys Thr Thr Lys  Pro Lys Ser 
    1310                 1315                 1320             


Leu Phe  Lys Leu Ala Glu Ser  Arg Asn Glu Leu 
    1325                 1330                 


<210> 431
<211> 1112
<212> PRT
<213> Staphylococcus simulans


<220>
<223> Staphylococcus simulans ACS-120-V-Sch1

<400> 431
Met Leu Val Gly Leu Lys Phe Lys Gln Ser Ile Leu Phe Glu Asn Met 
1               5                   10                  15      


Glu Asn Ala Glu Asp Ile Lys Glu Ser Ala Thr Gly Ser Asp Ala Ile 
            20                  25                  30          


Ser Leu Ser Asp Asp Tyr Tyr Glu Asn Leu Ser Glu Phe Leu Thr Asp 
        35                  40                  45              


Glu Gln Leu Asn Phe Ile Glu Ser Ala Asn Thr Phe Phe Met Gly Ile 
    50                  55                  60                  


Met Leu Asp Arg Ile Leu Lys Gly Ala Thr Ser Ile Ser Ala Ala Lys 
65                  70                  75                  80  


Val Arg Asp Tyr Lys Ile Phe Lys Ser Gln Leu Lys Leu Ile Lys Asp 
                85                  90                  95      


Ile Val Tyr Gln Asn Lys Tyr Asp Lys Tyr His Glu Phe Phe Val Thr 
            100                 105                 110         


Ser Lys Glu Asp Met Arg Ala Tyr Gln Glu Asn Pro Asp Ala Lys Asn 
        115                 120                 125             


Phe Gly Lys Leu Ser Lys Phe Asp Gln Tyr Leu Ile His Ser Lys Asp 
    130                 135                 140                 


Gln Tyr Ala Lys Leu Met Lys Asp Leu Lys Gly Leu Val Pro Lys Glu 
145                 150                 155                 160 


Tyr Thr Glu Val Leu Asn Leu Ile Asp Glu Gln Lys Phe Leu Val Val 
                165                 170                 175     


Gln Asn Thr Thr Asp Asn Ala Ser Ile Pro Tyr Gln Asn Asn Val Phe 
            180                 185                 190         


Glu Ala Glu Asn Ile Leu Arg Asn Gln Gln Lys Tyr Tyr Pro Glu Ile 
        195                 200                 205             


Thr Glu Glu Met Ile Gly Lys Val Ile Asn Leu Ile Ser Phe Arg Ile 
    210                 215                 220                 


Pro Tyr Tyr Val Gly Pro Leu Thr Asn Lys Asn Gly Gln Ser Asp Phe 
225                 230                 235                 240 


Ala Trp Met Ile Arg Lys Ser Asp Glu Gln Thr Leu Pro Trp Asn Phe 
                245                 250                 255     


Asp Lys Val Ile Asp Lys Ser Lys Ser Ala Glu Lys Phe Ile Arg Arg 
            260                 265                 270         


Met Thr Ser Lys Cys Thr Tyr Leu Leu Glu Glu Asp Val Leu Pro Lys 
        275                 280                 285             


His Ser Leu Leu Tyr Gln Glu Met Glu Val Leu Asn Glu Leu Asn Asn 
    290                 295                 300                 


Val Gln Leu Arg Gly Glu Asn Glu Pro Lys His Arg Ile His Arg Leu 
305                 310                 315                 320 


Asp Pro Lys Val Lys Gln Phe Ile Tyr His Asn Leu Phe Gln Lys Lys 
                325                 330                 335     


Lys Asn Val Thr His Lys Asp Leu Ile Thr Leu Leu Gln Asn Ser Glu 
            340                 345                 350         


His Arg Asn Thr Leu Asn Lys Thr Ser Gly Gln Lys Leu Lys Val Phe 
        355                 360                 365             


Gly Thr Gln Asn Asp Ser Lys Phe Ala Ser Lys Leu Ser Thr Tyr Asn 
    370                 375                 380                 


Asp Met Lys Ala Ile Leu Gly Ser Val Glu Asn Lys Arg Gln Met Ile 
385                 390                 395                 400 


Glu Glu Leu Val Leu Trp Ile Thr Ile Phe Glu Asp Lys Ala Ile Leu 
                405                 410                 415     


Lys Gln Lys Ile Gly Glu Lys Tyr Pro Asn Ile Thr Glu Lys Gln Leu 
            420                 425                 430         


Asn Gln Ile Val Lys Leu Asn Tyr Ser Gly Trp Gly Arg Leu Ser Glu 
        435                 440                 445             


Lys Leu Leu Thr Lys Glu Val Asn Gly Arg Ser Leu Ile Asp Leu Met 
    450                 455                 460                 


Tyr Ser Thr Glu Asn Asn Phe Met Glu Ile Ile Thr Asp Lys Thr Leu 
465                 470                 475                 480 


Gly Phe Asp Cys Phe Ile Lys Asn Ser Asn Lys Val Lys Asn Ala Lys 
                485                 490                 495     


Ile Ser Tyr Lys Asp Val Ala Glu Leu Arg Thr Ser Pro Ala Leu Lys 
            500                 505                 510         


Lys Gly Ile Trp Asn Ala Ile Lys Met Val Arg Glu Ile Ser Asn Leu 
        515                 520                 525             


Phe Gly Ala Pro Glu Lys Ile Ile Ile Glu Phe Ala Thr Glu Asp Gln 
    530                 535                 540                 


Ala Lys Gly Lys Arg Gln Lys Ser Arg Ser Glu Leu Trp Asp Asp Leu 
545                 550                 555                 560 


Val Lys Lys Asn Asn Leu Lys Arg Asn Lys Glu Phe Glu Gly Leu Phe 
                565                 570                 575     


Glu Glu Leu Lys Ala Tyr Pro Asp Leu Asp Phe Ser Asn Pro Lys Leu 
            580                 585                 590         


Trp Leu Tyr Ile His Gln Asn Gly Lys Cys Met Tyr Thr Lys Lys Pro 
        595                 600                 605             


Ile Asp Leu Glu Arg Leu Met Ser Asp Thr Asn Asn Gln Leu Tyr Glu 
    610                 615                 620                 


Ile Asp His Ile Leu Pro Arg Thr Phe Val Lys Asp Asp Ser Ile Asn 
625                 630                 635                 640 


Asn Lys Val Leu Val Ile Gln Ser Ala Asn Gln Lys Lys Ser Gly Asp 
                645                 650                 655     


Lys Met Pro Leu Glu Ile Phe Asp Asn His Val Leu Val Pro Phe Trp 
            660                 665                 670         


Lys Met Leu Tyr Glu Asn Asp Leu Ile Ser Ser Ser Lys Leu Ser Lys 
        675                 680                 685             


Leu Met Lys Lys Glu Phe Asn Asp Leu Asp Lys Glu Gly Phe Ile Gln 
    690                 695                 700                 


Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Ser His Val Ser Asp Phe 
705                 710                 715                 720 


Leu Thr Glu Glu Tyr Pro Ser Thr Thr Val Val Pro Met Lys Ala Asn 
                725                 730                 735     


Val Val Ser Glu Leu Arg Arg Lys Phe Asp Ile Pro Lys Ile Arg Gln 
            740                 745                 750         


Leu Asn Asp Trp His His Ala Val Asp Ala Tyr Leu Asn Gly Phe Val 
        755                 760                 765             


Tyr Gln Ala Ala Arg Val Phe Tyr Pro Lys Val Asn Leu Phe Glu Phe 
    770                 775                 780                 


Asn Phe Lys Trp Glu Lys Val Arg Glu Lys Trp Arg Gln Leu Gly Glu 
785                 790                 795                 800 


Phe Thr Glu Asn Asn Lys Lys Arg Glu Phe Phe Leu Phe Lys Arg Met 
                805                 810                 815     


Glu Asn Tyr Val Asn Glu Tyr Gly Glu Gly Met Ile Ser Lys Leu Ile 
            820                 825                 830         


Phe Asp Leu Asp Asn Phe Lys Phe Asn Tyr Ser Arg Lys Val Glu Ser 
        835                 840                 845             


Thr Glu Ser Ala Phe Tyr Lys Gln Ser Ala Phe Ser Pro Lys Asn Thr 
    850                 855                 860                 


Thr Ala Gln Tyr Asp Ser Asp Lys Asn Lys Thr Ala Ile Tyr Lys Glu 
865                 870                 875                 880 


Met Lys Asn Lys Arg Gly Ile Val Val Ser Tyr Thr Tyr Val Lys Lys 
                885                 890                 895     


Asp Gln Glu Leu Ile Gly Tyr Gly Val Phe Asn Glu Thr Val Phe Glu 
            900                 905                 910         


Tyr Val Asn Asn Ala Asp Val Asp Met Asn Thr Arg Ala Leu Lys Ile 
        915                 920                 925             


Val Arg Lys Ala Phe Pro Lys Leu Asp Ile Lys Lys Ala Gln Tyr Leu 
    930                 935                 940                 


Phe Ser Ile Asn Lys Gly Asp Ala Leu Leu Val Asn Gly His Pro Phe 
945                 950                 955                 960 


Leu Phe Val Ser Ala Tyr Glu Arg Ile Asn Gly Lys Gln Leu Glu Phe 
                965                 970                 975     


Asp Ile Ala Met Gln Arg Lys Ile Lys Gln Ala Leu Ser Pro Tyr Asn 
            980                 985                 990         


Asn Met Thr Glu Gln Glu Lys Val  Glu Phe Tyr Asn Gln  Phe Ala Glu 
        995                 1000                 1005             


Lys Val  Ile Glu Glu Phe Arg  Asn Ser Ile Gly Leu  Gln Ser Arg 
    1010                 1015                 1020             


Asp Arg  Lys Val Asn Leu Ile  Lys Asn Leu Phe Asn  Asn Thr Glu 
    1025                 1030                 1035             


Lys Ser  Asn Asp Ser Met Thr  Gln Ser Ile Leu Glu  Val Leu Lys 
    1040                 1045                 1050             


Met Thr  Lys Val Ser Ala Glu  Arg Ser Lys Glu Leu  Lys Ile Arg 
    1055                 1060                 1065             


Trp Asn  Gly Gln Thr Pro Asn  Thr Phe Ile Asp Thr  Lys Asn Asn 
    1070                 1075                 1080             


Ala Glu  Ile Gln Tyr Lys Ser  Ile Thr Gly Leu Lys  Thr Thr Lys 
    1085                 1090                 1095             


Pro Lys  Ser Ile Phe Lys Leu  Ala Glu Ser Lys Asn  Glu Leu 
    1100                 1105                 1110         


<210> 432
<211> 1370
<212> PRT
<213> Streptococcus agalactiae


<220>
<223> Streptococcus agalactiae 2603V/R

<400> 432
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210> 433
<211> 1377
<212> PRT
<213> Streptococcus agalactiae


<220>
<223> Streptococcus agalactiae 515

<400> 433
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His His Glu Asp Leu Lys His Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Asn Tyr Arg Glu Val Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Leu Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Val Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Lys Cys Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Asp Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Ser Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Lys Lys Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Glu Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Met Phe Trp Lys Asn Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Val Asp Asn Gly Lys Lys Ile Cys Lys Val Lys Ile Val 
945                 950                 955                 960 


Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly Phe 
                965                 970                 975     


Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr 
            980                 985                 990         


Leu Asn Ala Val Val Ala Lys Ala  Ile Leu Thr Lys Tyr  Pro Gln Leu 
        995                 1000                 1005             


Glu Pro  Glu Phe Val Tyr Gly  Met Tyr Arg Gln Lys  Lys Leu Ser 
    1010                 1015                 1020             


Lys Ile  Val His Glu Asp Lys  Glu Glu Lys Tyr Ser  Glu Ala Thr 
    1025                 1030                 1035             


Arg Lys  Met Phe Phe Tyr Ser  Asn Leu Met Asn Met  Phe Lys Arg 
    1040                 1045                 1050             


Val Val  Arg Leu Ala Asp Gly  Ser Ile Val Val Arg  Pro Val Ile 
    1055                 1060                 1065             


Glu Thr  Gly Arg Tyr Met Gly  Lys Thr Ala Trp Asp  Lys Lys Lys 
    1070                 1075                 1080             


His Phe  Ala Thr Val Arg Lys  Val Leu Ser Tyr Pro  Gln Asn Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Thr Glu Ile  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Ala His Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Asp Ile Tyr Leu Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Ile Val Ala Tyr Ser  Val Leu Val Val Ala  Asp Ile Lys 
    1145                 1150                 1155             


Lys Gly  Lys Ala Gln Lys Leu  Lys Thr Val Thr Glu  Leu Leu Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Arg Ser  Arg Phe Glu Lys Asn  Pro Ser Ala 
    1175                 1180                 1185             


Phe Leu  Glu Ser Lys Gly Tyr  Leu Asn Ile Arg Asp  Asp Lys Leu 
    1190                 1195                 1200             


Met Ile  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Leu Ala  Leu Pro Thr Gln Phe  Met Lys Phe Leu Tyr  Leu Ala Ser 
    1235                 1240                 1245             


Arg Tyr  Asn Glu Ser Lys Gly  Lys Pro Glu Glu Ile  Glu Lys Lys 
    1250                 1255                 1260             


Gln Glu  Phe Val Asn Gln His  Val Ser Tyr Phe Asp  Asp Ile Leu 
    1265                 1270                 1275             


Gln Leu  Ile Asn Asp Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1280                 1285                 1290             


Asn Leu  Glu Lys Ile Asn Lys  Leu Tyr Gln Asp Asn  Lys Glu Asn 
    1295                 1300                 1305             


Ile Pro  Val Asp Glu Leu Ala  Asn Asn Ile Ile Asn  Leu Phe Thr 
    1310                 1315                 1320             


Phe Thr  Ser Leu Gly Ala Pro  Ala Ala Phe Lys Phe  Phe Asp Lys 
    1325                 1330                 1335             


Ile Val  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asn 
    1340                 1345                 1350             


Ser Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Gly Lys Leu Gly  Glu Asp 
    1370                 1375         


<210> 434
<211> 1370
<212> PRT
<213> Streptococcus agalactiae

<400> 434
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210> 435
<211> 1378
<212> PRT
<213> Streptococcus agalactiae


<220>
<223> Streptococcus agalactiae ATCC 13813

<400> 435
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Arg Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His His Glu Asp Leu Lys His Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Asn Tyr Arg Glu Val Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Ser Gln Glu Ala Phe Tyr Lys Tyr Leu Leu Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Leu Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Ile Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Lys Asp Ala Gly Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Ser Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Gly Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Asp Glu 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Glu Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Met Phe Trp Lys Asn Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Leu Tyr Arg Arg  Lys Lys Leu 
    1010                 1015                 1020             


Ser Lys  Ile Val Arg Glu Asp  Lys Glu Glu Lys Tyr  Ser Glu Ala 
    1025                 1030                 1035             


Thr Arg  Lys Met Phe Phe Tyr  Ser Asn Leu Met Asn  Met Phe Lys 
    1040                 1045                 1050             


Arg Val  Val Arg Leu Ala Asp  Gly Ser Ile Val Val  Arg Pro Val 
    1055                 1060                 1065             


Ile Glu  Thr Gly Arg Tyr Met  Gly Lys Thr Ala Trp  Asp Lys Lys 
    1070                 1075                 1080             


Lys His  Phe Ala Thr Val Arg  Lys Val Leu Ser Tyr  Pro Gln Asn 
    1085                 1090                 1095             


Asn Ile  Val Lys Lys Thr Glu  Ile Gln Thr Gly Gly  Phe Ser Lys 
    1100                 1105                 1110             


Glu Ser  Ile Leu Ala His Gly  Asn Ser Asp Lys Leu  Ile Pro Arg 
    1115                 1120                 1125             


Lys Thr  Lys Asp Ile Tyr Leu  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1130                 1135                 1140             


Asp Ser  Pro Ile Val Ala Tyr  Ser Val Leu Val Val  Ala Asp Ile 
    1145                 1150                 1155             


Lys Lys  Gly Lys Ala Gln Lys  Leu Lys Thr Val Thr  Glu Leu Leu 
    1160                 1165                 1170             


Gly Ile  Thr Ile Met Glu Arg  Ser Arg Phe Glu Lys  Asn Thr Ser 
    1175                 1180                 1185             


Ala Phe  Leu Glu Ser Lys Gly  Tyr Leu Asn Ile Arg  Asp Asp Lys 
    1190                 1195                 1200             


Leu Met  Ile Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1205                 1210                 1215             


Arg Arg  Arg Leu Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1220                 1225                 1230             


Glu Leu  Ala Leu Pro Thr Gln  Phe Met Lys Phe Leu  Tyr Leu Ala 
    1235                 1240                 1245             


Ser Arg  Tyr Asn Glu Ser Lys  Gly Lys Pro Glu Glu  Ile Glu Lys 
    1250                 1255                 1260             


Lys Gln  Glu Phe Val Asn Gln  His Val Ser Tyr Phe  Asp Asp Ile 
    1265                 1270                 1275             


Leu Gln  Leu Ile Asn Asp Phe  Ser Asn Arg Val Ile  Leu Ala Asp 
    1280                 1285                 1290             


Ala Asn  Leu Glu Lys Ile Asn  Lys Leu Tyr Gln Asp  Asn Lys Glu 
    1295                 1300                 1305             


Asn Ile  Pro Val Asp Glu Leu  Ala Asn Asn Ile Ile  Asn Leu Phe 
    1310                 1315                 1320             


Thr Phe  Thr Ser Leu Gly Ala  Pro Ala Ala Phe Lys  Phe Phe Asp 
    1325                 1330                 1335             


Lys Ile  Val Asp Arg Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu 
    1340                 1345                 1350             


Asn Ser  Thr Leu Ile His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr 
    1355                 1360                 1365             


Arg Ile  Asp Leu Gly Lys Leu  Gly Glu Gly 
    1370                 1375             


<210> 436
<211> 1370
<212> PRT
<213> Streptococcus agalactiae


<220>
<223> Streptococcus agalactiae CJB111


<220>
<221> MOD_RES
<222> (117)..(117)
<223> Any amino acid

<400> 436
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Xaa Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210> 437
<211> 1370
<212> PRT
<213> Streptococcus agalactiae


<220>
<223> Streptococcus agalactiae COH1

<400> 437
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ser Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Asp Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asn Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Arg Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Ile Asp 
        195                 200                 205             


Val Glu Gly Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Thr Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Gly Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Leu Val Asp Lys Glu Ala Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Pro Ile Ile Asp Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Val Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Thr Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Glu Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Phe 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210> 438
<211> 1370
<212> PRT
<213> Streptococcus agalactiae


<220>
<223> Streptococcus agalactiae FSL S3-026

<400> 438
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Arg Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Leu Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Val Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Lys Asp Ala Gly Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Leu Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Asp Glu 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Val Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Asp Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210> 439
<211> 1370
<212> PRT
<213> Streptococcus agalactiae


<220>
<223> Streptococcus agalactiae GB00112

<400> 439
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ser Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Asp Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Arg Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Ile Asp 
        195                 200                 205             


Val Glu Gly Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Thr Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Gly Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Leu Val Asp Lys Glu Ala Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Pro Ile Ile Asp Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Val Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Thr Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Glu Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Phe 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210> 440
<211> 1370
<212> PRT
<213> Streptococcus agalactiae


<220>
<223> Streptococcus agalactiae H36B


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Any amino acid

<400> 440
Met Asn Lys Pro Tyr Ser Ile Gly Xaa Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210> 441
<211> 1377
<212> PRT
<213> Streptococcus agalactiae

<400> 441
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His His Glu Asp Leu Lys His Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Asn Tyr Arg Glu Val Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Leu Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Val Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Lys Cys Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Asp Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Ser Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Lys Lys Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Glu Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Met Phe Trp Lys Asn Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Val Asp Asn Gly Lys Lys Ile Cys Lys Val Lys Ile Val 
945                 950                 955                 960 


Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly Phe 
                965                 970                 975     


Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr 
            980                 985                 990         


Leu Asn Ala Val Val Ala Lys Ala  Ile Leu Thr Lys Tyr  Pro Gln Leu 
        995                 1000                 1005             


Glu Pro  Glu Phe Val Tyr Gly  Met Tyr Arg Gln Lys  Lys Leu Ser 
    1010                 1015                 1020             


Lys Ile  Val His Glu Asp Lys  Glu Glu Lys Tyr Ser  Glu Ala Thr 
    1025                 1030                 1035             


Arg Lys  Met Phe Phe Tyr Ser  Asn Leu Met Asn Met  Phe Lys Arg 
    1040                 1045                 1050             


Val Val  Arg Leu Ala Asp Gly  Ser Ile Val Val Arg  Pro Val Ile 
    1055                 1060                 1065             


Glu Thr  Gly Arg Tyr Met Arg  Lys Thr Ala Trp Asp  Lys Lys Lys 
    1070                 1075                 1080             


His Phe  Ala Thr Val Arg Lys  Val Leu Ser Tyr Pro  Gln Asn Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Thr Glu Ile  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Ala His Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Asp Ile Tyr Leu Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Ile Val Ala Tyr Ser  Val Leu Val Val Ala  Asp Ile Lys 
    1145                 1150                 1155             


Lys Gly  Lys Ala Gln Lys Leu  Lys Thr Val Thr Glu  Leu Leu Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Arg Ser  Arg Phe Glu Lys Asn  Pro Ser Ala 
    1175                 1180                 1185             


Phe Leu  Glu Ser Lys Gly Tyr  Leu Asn Ile Arg Asp  Asp Lys Leu 
    1190                 1195                 1200             


Met Ile  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Leu Ala  Leu Pro Thr Gln Phe  Met Lys Phe Leu Tyr  Leu Ala Ser 
    1235                 1240                 1245             


Arg Tyr  Asn Glu Ser Lys Gly  Lys Pro Glu Glu Ile  Glu Lys Lys 
    1250                 1255                 1260             


Gln Glu  Phe Val Asn Gln His  Val Ser Tyr Phe Asp  Asp Ile Leu 
    1265                 1270                 1275             


Gln Leu  Ile Asn Asp Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1280                 1285                 1290             


Asn Leu  Glu Lys Ile Asn Lys  Leu Tyr Gln Asp Asn  Lys Glu Asn 
    1295                 1300                 1305             


Ile Pro  Val Asp Glu Leu Ala  Asn Asn Ile Ile Asn  Leu Phe Thr 
    1310                 1315                 1320             


Phe Thr  Ser Leu Gly Ala Pro  Ala Ala Phe Lys Phe  Phe Asp Lys 
    1325                 1330                 1335             


Ile Val  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asn 
    1340                 1345                 1350             


Ser Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Gly Lys Leu Gly  Glu Asp 
    1370                 1375         


<210> 442
<211> 1370
<212> PRT
<213> Streptococcus agalactiae

<400> 442
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Ser Phe Glu Asn Asn His Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Val 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Gln Leu Leu Asp Phe Leu Ala Lys Glu Phe Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Ile Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Arg Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ser Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asp Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Pro Asp Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Lys Val Asp Asp Asn Asn Lys Pro Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Glu 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Glu Thr Gly 
    1055                 1060                 1065             


Glu Ile  Ala Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Ser Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Leu Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Lys Glu Leu Ile  Gly Ile Thr Ile Met  Glu Arg Glu 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Thr Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Ser Asp Asn Lys Asp  Asn Thr Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Lys Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ser Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asp Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210> 443
<211> 1370
<212> PRT
<213> Streptococcus agalactiae


<220>
<223> Streptococcus agalactiae STIR-CD-17

<400> 443
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Ser Phe Glu Asn Asn His Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Tyr Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Val 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Gln Leu Leu Asp Phe Leu Ala Lys Glu Phe Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Ile Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Arg Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ser Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asp Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Pro Asp Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Lys Val Asp Asp Asn Asn Lys Pro Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Glu 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Glu Thr Gly 
    1055                 1060                 1065             


Glu Ile  Ala Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Ser Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Leu Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Lys Glu Leu Ile  Gly Ile Thr Ile Met  Glu Arg Glu 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Thr Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Ile Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Ser Asp Asn Lys Asp  Asn Thr Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Lys Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ser Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asp Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210> 444
<211> 1125
<212> PRT
<213> Streptococcus anginosus


<220>
<223> Streptococcus anginosus 1_2_62CV

<400> 444
Met Asn Gly Leu Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Glu Thr Gly Glu Ile Ile His Ala Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Thr Ala Asp Ser Asn Val Glu Arg Arg Gly 
        35                  40                  45              


Phe Arg Gln Gly Arg Arg Leu Gly Arg Arg Lys Lys His Arg Ser Ala 
    50                  55                  60                  


Arg Leu Asn Asn Leu Phe Glu Glu Phe Gly Phe Ile Thr Asp Phe Ser 
65                  70                  75                  80  


Ala Ile Pro Leu Asn Leu Asn Pro Tyr Ala Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Glu Glu Leu Thr Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Ile 
            100                 105                 110         


Ile Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly 
        115                 120                 125             


Glu Thr Ala Ser Asn Glu Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 
    130                 135                 140                 


Leu Leu Ala Asp Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe Glu 
145                 150                 155                 160 


Lys Tyr Gly Gln Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly Glu 
                165                 170                 175     


Asn His Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Lys Lys Glu 
            180                 185                 190         


Ala Glu Arg Ile Leu Arg Arg Gln Gln Glu Phe Asn Val Arg Ile Ser 
        195                 200                 205             


Asp Glu Phe Ile Glu Ala Tyr Leu Thr Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Tyr Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Pro Glu Gln Lys Arg Gln Ile 
    290                 295                 300                 


Val Glu Tyr Ala Arg Thr Ala Lys Thr Leu Gly Thr Pro Thr Leu Leu 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Val Asp Gly Ser Ile Asp Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Asp Lys Pro Glu Met His Thr Phe Asp Ala 
            340                 345                 350         


Tyr Arg Lys Met Arg Thr Leu Asp Leu Val Asn Ile Asp Ala Leu Ser 
        355                 360                 365             


Arg Glu Thr Leu Asp Asp Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Ser Glu Gly Ile Leu Glu Ala Leu Asn Ser Lys Met Pro Ser Thr Phe 
385                 390                 395                 400 


Thr Lys Glu Gln Ile Asp Glu Leu Ile Gln Phe Arg Lys Lys Asn Ser 
                405                 410                 415     


Ala Val Phe Gly Lys Gly Trp His Asn Phe Ser Leu Lys Leu Met Asn 
            420                 425                 430         


Glu Leu Ile Ser Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Gly Lys Gln Arg Ser Arg Glu Ile Ser Lys Arg Thr 
    450                 455                 460                 


Lys Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn Pro Val 
465                 470                 475                 480 


Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Glu Ala Thr 
                485                 490                 495     


Lys Arg Tyr Gly Ile Phe Asp Asn Ile Val Ile Glu Met Ala Arg Glu 
            500                 505                 510         


Asn Asn Glu Glu Asp Ala Lys Lys Asp Tyr Ile Lys Arg Gln Lys Ala 
        515                 520                 525             


Asn Gln Asp Glu Lys Asn Ala Ser Met Glu Lys Ala Ala Phe Gln Tyr 
    530                 535                 540                 


Asn Gly Lys Lys Glu Leu Pro Asp Ser Ile Phe His Gly His Lys Glu 
545                 550                 555                 560 


Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys Leu 
                565                 570                 575     


Tyr Thr Gly Lys Asn Ile Ser Ile Arg Asp Leu Ile His Asn Pro His 
            580                 585                 590         


Gln Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp Asp 
        595                 600                 605             


Gly Leu Ala Asn Lys Val Leu Val Leu Ala Thr Ala Asn Gln Glu Lys 
    610                 615                 620                 


Gly Gln Arg Thr Pro Phe Gln Ala Ile Asp Ser Met Asp Asp Ala Trp 
625                 630                 635                 640 


Ser Tyr Arg Glu Phe Lys Gln Tyr Val Arg Asn Ser Lys Ser Leu Ser 
                645                 650                 655     


Asn Lys Lys Lys Asp Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys Ile 
            660                 665                 670         


Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg Tyr 
        675                 680                 685             


Ser Ser Arg Val Val Leu Asn Thr Leu Gln Glu Phe Tyr Lys Thr Asn 
    690                 695                 700                 


Asp Phe Asp Thr Lys Ile Ser Val Val Arg Gly Gln Phe Thr Ser Gln 
705                 710                 715                 720 


Leu Arg Arg Lys Trp Lys Ile Glu Lys Ser Arg Asp Thr Tyr His His 
                725                 730                 735     


His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg Leu 
            740                 745                 750         


Trp Lys Lys Gln Asn Asn Pro Leu Ile Ser Tyr Lys Glu Gly Gln Phe 
        755                 760                 765             


Val Asp Pro Glu Thr Gly Glu Ile Leu Ser Leu Thr Asp Asp Glu Tyr 
    770                 775                 780                 


Lys Glu Leu Val Phe Arg Pro Pro Tyr Asp Tyr Phe Val Asp Thr Leu 
785                 790                 795                 800 


Lys Ser Lys Ser Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Tyr Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Gly Thr Arg 
            820                 825                 830         


Lys Ala Gln Leu Gly Lys Asp Lys Gln Glu Glu Thr Tyr Val Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ser Gln Lys Gly Tyr Glu Asp Phe Ile Lys 
    850                 855                 860                 


Arg Tyr Asn Lys Asp Glu Thr Gln Phe Leu Ile Tyr His Lys Asp Pro 
865                 870                 875                 880 


Gln Thr Phe Glu Lys Val Ile Glu Glu Ile Leu Lys Thr Tyr Pro Asp 
                885                 890                 895     


Lys Glu Leu Asn Glu Lys Gly Lys Glu Ile Pro Cys Asn Pro Phe Glu 
            900                 905                 910         


Lys Tyr Arg Gln Glu Asn Gly Pro Ile Arg Lys Tyr Ser Lys Lys Gly 
        915                 920                 925             


Lys Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly 
    930                 935                 940                 


Asn His Ile Asp Ile Thr Pro Val Asn Ser Gln Asn Gln Val Val Leu 
945                 950                 955                 960 


Gln Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Pro Arg Thr 
                965                 970                 975     


Ser Lys Tyr Glu Leu Met Gly Leu Lys Tyr Ser Asp Leu Arg Phe Glu 
            980                 985                 990         


Lys Gly Ser Gly Ser Tyr Gly Ile  Ser Pro Glu Lys Tyr  Asn Lys Val 
        995                 1000                 1005             


Lys Ala  Lys Glu Gly Val Asn  Glu Asp Ser Glu Phe  Lys Phe Thr 
    1010                 1015                 1020             


Leu Tyr  Lys Asn Asp Leu Ile  Leu Ile Lys Asp Thr  Glu Thr Gly 
    1025                 1030                 1035             


Glu Gln  Gln Leu Phe Arg Tyr  Gly Ser Arg Asn Asp  Thr Ser Lys 
    1040                 1045                 1050             


His Tyr  Val Glu Leu Lys Pro  Tyr Glu Lys Ala Lys  Phe Glu Gly 
    1055                 1060                 1065             


Asn Gln  Gln Leu Met Asn Leu  Leu Gly Thr Val Ala  Lys Gly Gly 
    1070                 1075                 1080             


Gln Cys  Leu Lys Gly Ile Asn  Lys Pro Asn Leu Ser  Ile Tyr Lys 
    1085                 1090                 1095             


Val Lys  Thr Asp Val Leu Gly  Asn Lys Tyr Phe Ile  Lys Lys Glu 
    1100                 1105                 1110             


Gly Asp  Gln Pro Gln Leu Asn  Phe Lys Lys Lys Phe  
    1115                 1120                 1125 


<210> 445
<211> 1345
<212> PRT
<213> Streptococcus anginosus


<220>
<223> Streptococcus anginosus F0211

<400> 445
Met Asp Gln Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Gln Ser Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Asn Lys Val Asp Glu Asn 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Asp Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Ile Ala Ala Glu Val Lys Tyr 
        115                 120                 125             


His Asp Asp Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ile Ser Gln Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asn Val Gln Ala Leu Phe Lys Asp Phe Val Glu Val Tyr 
            180                 185                 190         


Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Met Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala His Tyr Pro Ala Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Leu Leu Gly Glu Ile Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Glu Glu His Gln Lys Asp Leu Lys Lys Leu Lys 
                325                 330                 335     


Asp Phe Ile Lys Val Asn Ala Pro Asp Gln Tyr Asn Ala Ile Phe Lys 
            340                 345                 350         


Asp Lys Asn Lys Lys Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Gly Ile Leu Leu Gln Ile Asn 
    370                 375                 380                 


Gly Ser Gly Asp Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Glu Glu His Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp 
465                 470                 475                 480 


Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Glu Ala Lys Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Val Asn Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ser Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu 
        595                 600                 605             


Asp Asp Lys Ala Asn Glu Lys Thr Ile Glu Asp Ile Ile Gln Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Ile Phe Thr Lys Ala Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Arg Ala Gln Ile Ile Gly Asp Val Asp Asp 
705                 710                 715                 720 


Ile Ala Asn Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly His Asn Pro Ala Asn Ile Ile Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Met Thr Asp Lys Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Leu Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Asn Leu Asp Asn Pro Val Asn Ile Lys Asn Val 
785                 790                 795                 800 


Glu Asn Gln Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Glu Thr Leu Asp Ile Asn Asn Leu 
            820                 825                 830         


Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp 
        835                 840                 845             


Asn Ser Leu Asp Asn Arg Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Ile Glu Val Val His Glu Met Lys Ser 
865                 870                 875                 880 


Phe Trp Ser Lys Leu Leu Ser Val Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Glu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Glu Arg Phe Asn Thr Glu Phe Asp Gly 
    930                 935                 940                 


Asn Lys Arg Arg Ile Arg Asn Val Lys Ile Ile Thr Leu Lys Ser Asn 
945                 950                 955                 960 


Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Asn Ala Leu Leu Leu Lys Tyr  Pro Gln Leu Glu Pro  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Glu Tyr Pro Lys Tyr  Asn Ser Tyr Arg Ser  Arg Lys Ser 
    1010                 1015                 1020             


Ala Thr  Glu Lys Phe Leu Phe  Tyr Ser Asn Ile Leu  Arg Phe Phe 
    1025                 1030                 1035             


Lys Lys  Glu Asp Ile Gln Thr  Asn Glu Asp Gly Glu  Ile Ala Trp 
    1040                 1045                 1050             


Asn Lys  Glu Lys His Ile Lys  Ile Leu Arg Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Glu Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Asn  Ser Tyr Trp Asn Pro  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Val  Val Ala Tyr Ser Ile  Leu Val Phe 
    1115                 1120                 1125             


Ala Asp  Val Glu Lys Gly Lys  Ser Lys Lys Leu Arg  Lys Val Gln 
    1130                 1135                 1140             


Asp Met  Val Gly Ile Thr Ile  Met Glu Lys Lys Arg  Phe Glu Lys 
    1145                 1150                 1155             


His Pro  Val Asp Phe Leu Glu  Gln Arg Gly Tyr Arg  Asn Val Arg 
    1160                 1165                 1170             


Leu Glu  Lys Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1175                 1180                 1185             


Glu Asn  Lys Arg Arg Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Leu Val Ile  Pro Gln Arg Phe Thr  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ser Tyr Gln Ile Glu  Lys Asn Tyr Glu Pro  Glu His Arg 
    1220                 1225                 1230             


Glu Tyr  Val Glu Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Glu 
    1235                 1240                 1245             


Tyr Ile  Ser Val Phe Ser Arg  Lys Tyr Val Leu Ala  Asp Asn Asn 
    1250                 1255                 1260             


Leu Thr  Lys Ile Glu Met Leu  Phe Ser Lys Asn Lys  Asp Ala Glu 
    1265                 1270                 1275             


Val Ser  Ser Leu Ala Lys Ser  Phe Ile Ser Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Phe  Gly Ala Pro Ala Ala  Phe Asn Phe Phe Gly  Glu Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Val Thr Glu Cys Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Glu Asp  
    1340                 1345 


<210> 446
<211> 1386
<212> PRT
<213> Streptococcus anginosus


<220>
<223> Streptococcus anginosus SK1138

<400> 446
Met Asn Gln Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Gln Ser Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Met Gln Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Asp Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Ile Ala Ala Glu Val Lys Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ile Ser Gln Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asn Val Gln Ala Leu Phe Lys Asp Phe Val Glu Val Tyr 
            180                 185                 190         


Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala His Tyr Pro Ala Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Phe Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Leu Leu Gly Glu Val Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Glu Glu His Gln Lys Asp Leu Lys Lys Phe Glu 
                325                 330                 335     


Asp Phe Ile Lys Val Asn Ala Leu Asp Gln Tyr Asn Ala Ile Phe Lys 
            340                 345                 350         


Asp Lys Asn Lys Lys Gly Tyr Ala Gly Tyr Ile Glu Ser Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Gly Ile Leu Leu Gln Ile Asn 
    370                 375                 380                 


Gly Ser Gly Asp Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp 
465                 470                 475                 480 


Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Glu Ala Lys Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Val Asn Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ser Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asn Lys Ser Phe Leu 
        595                 600                 605             


Asp Asn Lys Glu Asn Ala Gln Ile Ile Glu Asp Ile Ile Gln Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Ile Phe Thr Lys Ala Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Ile Ile Gly Asp Val Asp Asp 
705                 710                 715                 720 


Ile Ala Asn Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly His Asn Pro Ala Asn Ile Ile Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Asp Arg Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Leu Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Asn Leu Asp Asn Pro Val Asn Ile Lys Asn Val 
785                 790                 795                 800 


Glu Asn Gln Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Glu Thr Leu Asp Ile Asn Asn Leu 
            820                 825                 830         


Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Tyr Ile Lys Asp 
        835                 840                 845             


Asp Ser Phe Asp Asn Arg Val Leu Thr Ser Ser Ser Glu Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Ile Glu Val Val Cys Ala Arg Lys Ala 
865                 870                 875                 880 


Asp Trp Met Arg Leu Arg Lys Ala Gly Leu Ile Ser Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Asn Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Val Leu Asp Ala Arg Phe Asn Ala Lys His Asp Glu 
    930                 935                 940                 


Asn Lys Lys Val Ile Arg Asp Val Lys Ile Ile Thr Leu Lys Ser Asn 
945                 950                 955                 960 


Leu Val Ser Gln Phe Arg Lys Asp Phe Lys Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Ile 
            980                 985                 990         


Gly Thr Ala Leu Leu Lys Lys Tyr  Pro Lys Leu Ala Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Glu Phe Lys Lys Tyr  Asp Val Arg Lys Phe  Ile Ala Lys 
    1010                 1015                 1020             


Ser Asp  Lys Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Leu Met Asn Phe Phe  Lys Lys Glu Val Lys  Phe Ala Asp 
    1040                 1045                 1050             


Gly Thr  Val Val Glu Arg Pro  Asp Ile Glu Thr Ser  Glu Asp Gly 
    1055                 1060                 1065             


Glu Ile  Ala Trp Asn Lys Gln  Thr Asp Phe Lys Ile  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1085                 1090                 1095             


Gln Thr  His Gly Leu Asp Arg  Gly Lys Pro Arg Gly  Leu Phe Asn 
    1100                 1105                 1110             


Ala Asn  Pro Ser Pro Lys Pro  Lys Pro Asp Ser Ser  Glu Asn Leu 
    1115                 1120                 1125             


Val Gly  Val Lys Arg Asn Leu  Asp Pro Lys Lys Tyr  Gly Gly Tyr 
    1130                 1135                 1140             


Ala Gly  Ile Ser Asn Ser Tyr  Ala Val Leu Val Lys  Ala Ile Ile 
    1145                 1150                 1155             


Glu Lys  Gly Val Lys Lys Lys  Glu Thr Met Val Leu  Glu Phe Gln 
    1160                 1165                 1170             


Gly Ile  Ser Ile Leu Asp Arg  Ile Thr Phe Glu Lys  Asp Lys Arg 
    1175                 1180                 1185             


Ala Phe  Leu Leu Gly Lys Gly  Tyr Lys Asp Ile Lys  Lys Ile Ile 
    1190                 1195                 1200             


Glu Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Lys Asp  Gly Ser Arg 
    1205                 1210                 1215             


Arg Met  Leu Ala Ser Ile Leu  Ser Thr Asn Asn Lys  Arg Gly Glu 
    1220                 1225                 1230             


Ile His  Lys Gly Asn Glu Leu  Phe Val Pro Gln Lys  Phe Thr Thr 
    1235                 1240                 1245             


Leu Leu  Tyr His Ala Lys Arg  Ile Asn Asn Pro Ile  Asn Lys Asp 
    1250                 1255                 1260             


His Ile  Glu Tyr Val Lys Lys  His Arg Asp Asp Phe  Lys Glu Leu 
    1265                 1270                 1275             


Leu Asn  Tyr Val Leu Glu Phe  Asn Glu Lys Tyr Val  Gly Ala Thr 
    1280                 1285                 1290             


Lys Asn  Gly Glu Arg Leu Lys  Glu Ala Val Ala Asp  Phe Asp Ser 
    1295                 1300                 1305             


Lys Ser  Asn Glu Glu Ile Cys  Thr Ser Phe Leu Gly  Ala Val Asn 
    1310                 1315                 1320             


Ser Lys  Asn Ala Gly Leu Phe  Glu Leu Thr Ser Leu  Gly Ser Ala 
    1325                 1330                 1335             


Ser Asp  Phe Glu Phe Leu Gly  Val Lys Ile Pro Arg  Tyr Arg Asp 
    1340                 1345                 1350             


Tyr Thr  Pro Ser Ser Leu Leu  Lys Asp Ser Thr Leu  Ile His Gln 
    1355                 1360                 1365             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1370                 1375                 1380             


Gly Glu  Asp 
    1385     


<210> 447
<211> 1396
<212> PRT
<213> Streptococcus anginosus


<220>
<223> Streptococcus anginosus SK52 = DSM 20563

<400> 447
Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asn Arg Asp Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Glu Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Met Gln Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Glu Glu Asp Lys Gln 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Gly Thr Leu Lys Glu Glu Lys Glu Tyr 
        115                 120                 125             


His Lys Lys Phe Lys Thr Ile Tyr His Leu Arg Glu Glu Leu Ala Asn 
    130                 135                 140                 


Ser Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Tyr Glu Gly Asp Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Ala Leu Phe Lys Asp Phe Val Glu Glu Tyr 
            180                 185                 190         


Asp Lys Thr Ile Glu Glu Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Ser Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala His Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Ala Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Leu Leu Gly Glu Val Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Val Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Lys Glu His Lys Glu Glu Leu Ala Ala Phe Lys 
                325                 330                 335     


Arg Phe Ile Lys Glu Lys Leu Pro Lys Lys Tyr Glu Glu Ile Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ala Asp Lys Lys 
        355                 360                 365             


Leu Arg Lys Arg Ser Gly Lys Leu Ala Thr Glu Glu Glu Phe Tyr Lys 
    370                 375                 380                 


Tyr Val Lys Gly Ile Leu Asn Lys Val Glu Gly Ala Asp Tyr Phe Leu 
385                 390                 395                 400 


Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp 
                405                 410                 415     


Asn Gly Ser Ile Pro His Gln Ile His Leu Gln Glu Met His Ala Ile 
            420                 425                 430         


Leu Arg Arg Gln Gly Glu His Tyr Pro Phe Leu Lys Glu Asn Gln Asp 
        435                 440                 445             


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
    450                 455                 460                 


Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp Ala Glu Tyr Lys Ala Asp 
465                 470                 475                 480 


Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp Ile Leu Asp Lys Glu Lys 
                485                 490                 495     


Ser Ala Glu Lys Phe Ile Thr Arg Met Thr Leu Asn Asp Leu Tyr Leu 
            500                 505                 510         


Pro Glu Glu Lys Val Leu Pro Lys His Ser Pro Leu Tyr Glu Thr Phe 
        515                 520                 525             


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Asn Glu Gln Gly 
    530                 535                 540                 


Glu Ala Lys Phe Phe Asp Thr Asn Met Lys Gln Glu Ile Phe Asp His 
545                 550                 555                 560 


Val Phe Lys Glu Asn Arg Lys Val Thr Lys Asp Lys Leu Leu Asn Tyr 
                565                 570                 575     


Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile Val Asn Leu Thr Gly Leu 
            580                 585                 590         


Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
        595                 600                 605             


Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu Asp Asp Lys Val Asn Glu 
    610                 615                 620                 


Lys Ile Ile Glu Asp Ile Ile Gln Thr Leu Thr Leu Phe Glu Asp Arg 
625                 630                 635                 640 


Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr Ser Asp Ile Phe Thr Thr 
                645                 650                 655     


Gln Gln Leu Lys Glu Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg 
            660                 665                 670         


Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg Asn Lys Glu Asn Lys Lys 
        675                 680                 685             


Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Tyr Ala Asn Arg Asn Phe 
    690                 695                 700                 


Met Gln Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala 
705                 710                 715                 720 


Arg Ala Gln Ile Ile Gly Asp Val Asp Asp Ile Ala Asn Val Val His 
                725                 730                 735     


Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Val 
            740                 745                 750         


Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His Asn Pro Thr Asn 
        755                 760                 765             


Ile Ile Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Asp Lys Gly Arg 
    770                 775                 780                 


Arg Asn Ser Gln Gln Arg Leu Lys Leu Leu Gln Asp Ser Leu Lys Asn 
785                 790                 795                 800 


Leu Asp Asn Pro Val Asn Ile Lys Asn Val Glu Asn Gln Gln Leu Gln 
                805                 810                 815     


Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr 
            820                 825                 830         


Thr Gly Glu Thr Leu Asp Ile Asn Asn Leu Ser Gln Tyr Asp Ile Asp 
        835                 840                 845             


His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Leu Asp Asn Arg 
    850                 855                 860                 


Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asp Val Pro 
865                 870                 875                 880 


Ser Ile Glu Val Val His Glu Met Lys Ser Phe Trp Ser Lys Leu Leu 
                885                 890                 895     


Ser Val Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
            900                 905                 910         


Glu Arg Gly Gly Leu Thr Glu Asn Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Val Leu 
    930                 935                 940                 


Asp Ala Arg Phe Asn Ala Lys His Asp Glu Asn Lys Lys Val Ile Arg 
945                 950                 955                 960 


Asp Val Lys Ile Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg 
                965                 970                 975     


Lys Asp Phe Lys Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His 
            980                 985                 990         


Ala His Asp Ala Tyr Leu Asn Ala  Val Ile Gly Thr Ala  Leu Leu Lys 
        995                 1000                 1005             


Lys Tyr  Pro Lys Leu Ala Ser  Glu Phe Val Tyr Gly  Glu Phe Lys 
    1010                 1015                 1020             


Lys Tyr  Asp Val Arg Lys Phe  Ile Ala Lys Ser Asp  Lys Glu Ile 
    1025                 1030                 1035             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Leu Met Asn 
    1040                 1045                 1050             


Phe Phe  Lys Lys Glu Val Lys  Phe Ala Asp Gly Thr  Val Val Glu 
    1055                 1060                 1065             


Arg Pro  Asp Ile Glu Thr Ser  Glu Asp Gly Glu Ile  Ala Trp Asn 
    1070                 1075                 1080             


Lys Gln  Thr Asp Phe Lys Ile  Val Arg Lys Val Leu  Ser Tyr Pro 
    1085                 1090                 1095             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  His Gly Leu 
    1100                 1105                 1110             


Asp Arg  Gly Lys Pro Arg Gly  Leu Phe Asn Ala Asn  Pro Ser Pro 
    1115                 1120                 1125             


Lys Pro  Lys Pro Asp Ser Ser  Glu Asn Leu Val Gly  Ile Lys Arg 
    1130                 1135                 1140             


Asn Leu  Asp Pro Lys Lys Tyr  Gly Gly Tyr Ala Gly  Ile Ser Asn 
    1145                 1150                 1155             


Ser Tyr  Ala Val Leu Val Lys  Ala Ile Ile Glu Lys  Gly Val Lys 
    1160                 1165                 1170             


Lys Lys  Glu Thr Met Val Leu  Glu Phe Gln Gly Ile  Ser Ile Leu 
    1175                 1180                 1185             


Asp Arg  Ile Thr Phe Glu Lys  Asp Lys Arg Ala Phe  Leu Leu Gly 
    1190                 1195                 1200             


Lys Gly  Tyr Lys Asp Ile Lys  Lys Ile Ile Glu Leu  Pro Lys Tyr 
    1205                 1210                 1215             


Ser Leu  Phe Glu Leu Lys Asp  Gly Ser Arg Arg Met  Leu Ala Ser 
    1220                 1225                 1230             


Ile Leu  Ser Thr Asn Asn Lys  Arg Gly Glu Ile His  Lys Gly Asn 
    1235                 1240                 1245             


Glu Leu  Phe Val Pro Gln Lys  Phe Thr Thr Leu Leu  Tyr His Ala 
    1250                 1255                 1260             


Lys Arg  Ile Asn Asn Pro Ile  Asn Lys Asp His Ile  Glu Tyr Val 
    1265                 1270                 1275             


Lys Lys  His Arg Asp Asp Phe  Lys Glu Leu Leu Asn  Tyr Val Leu 
    1280                 1285                 1290             


Glu Phe  Asn Glu Lys Tyr Val  Gly Ala Thr Lys Asn  Gly Glu Arg 
    1295                 1300                 1305             


Leu Lys  Glu Ala Val Ala Asp  Phe Asp Ser Lys Ser  Asn Glu Glu 
    1310                 1315                 1320             


Ile Cys  Thr Ser Phe Leu Gly  Ala Val Asn Ser Lys  Asn Ala Gly 
    1325                 1330                 1335             


Leu Phe  Glu Leu Thr Ser Leu  Gly Ser Ala Ser Asp  Phe Glu Phe 
    1340                 1345                 1350             


Leu Gly  Val Lys Ile Pro Arg  Tyr Arg Asp Tyr Thr  Pro Ser Ser 
    1355                 1360                 1365             


Leu Leu  Lys Asp Ser Ile Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1370                 1375                 1380             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu Gly Glu  Asp 
    1385                 1390                 1395     


<210> 448
<211> 1373
<212> PRT
<213> Streptococcus bovis


<220>
<223> Streptococcus bovis ATCC 700338

<400> 448
Met Thr Lys Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Thr Lys Val Asp Glu 
                85                  90                  95      


Ser Phe Phe Gln Arg Leu Asp Glu Ser Phe Leu Arg Trp Asp Asp Asp 
            100                 105                 110         


Asn Lys Lys Leu Gly Arg Tyr Pro Ile Phe Gly Asn Lys Ala Asp Val 
        115                 120                 125             


Val Lys Tyr His Gln Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His 
    130                 135                 140                 


Leu Ala Asp Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala 
145                 150                 155                 160 


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu 
                165                 170                 175     


Leu Asn Ala Glu Asn Thr Asp Val Gln Lys Ile Phe Ala Asp Phe Val 
            180                 185                 190         


Gly Val Tyr Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr 
        195                 200                 205             


Val Asp Ala Ala Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg 
    210                 215                 220                 


Leu Glu Asn Leu Ile Lys Tyr Tyr Pro Thr Glu Lys Lys Asn Thr Leu 
225                 230                 235                 240 


Phe Gly Asn Leu Ile Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys 
                245                 250                 255     


Met Asn Phe Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp 
            260                 265                 270         


Ser Tyr Glu Glu Asp Leu Gly Glu Leu Leu Gly Lys Ile Gly Asp Asp 
        275                 280                 285             


Tyr Ala Asp Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu 
    290                 295                 300                 


Leu Ser Gly Ile Leu Ile Val Asp Asp Asn Ser Thr Lys Ala Pro Leu 
305                 310                 315                 320 


Ser Ala Ser Met Ile Lys Arg Tyr Val Glu His Gln Glu Asp Leu Glu 
                325                 330                 335     


Lys Leu Lys Glu Phe Ile Lys Ala Asn Lys Ser Glu Leu Tyr His Asp 
            340                 345                 350         


Ile Phe Lys Asp Lys Asn Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn 
        355                 360                 365             


Gly Val Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser 
    370                 375                 380                 


Lys Ile Ala Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp 
385                 390                 395                 400 


Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
                405                 410                 415     


Ile His Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr 
            420                 425                 430         


Tyr Pro Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr 
        435                 440                 445             


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asp Ser Arg 
    450                 455                 460                 


Phe Ser Trp Ala Glu Tyr His Ser Asp Glu Lys Ile Thr Pro Trp Asn 
465                 470                 475                 480 


Phe Asp Lys Val Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr 
                485                 490                 495     


Arg Met Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro 
            500                 505                 510         


Lys His Ser His Val Tyr Glu Thr Tyr Ala Val Tyr Asn Glu Leu Thr 
        515                 520                 525             


Lys Ile Lys Tyr Val Asn Glu Gln Gly Lys Asp Ser Phe Phe Asp Ser 
    530                 535                 540                 


Asn Met Lys Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys 
545                 550                 555                 560 


Val Thr Lys Glu Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu 
                565                 570                 575     


Tyr Arg Ile Lys Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe 
            580                 585                 590         


Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys 
        595                 600                 605             


Ala Phe Leu Asp Asp Lys Val Asn Glu Glu Val Ile Glu Asp Ile Ile 
    610                 615                 620                 


Lys Thr Leu Thr Leu Phe Glu Asp Lys Asp Met Ile His Glu Arg Leu 
625                 630                 635                 640 


Gln Lys Tyr Ser Asp Ile Phe Thr Ala Asp Gln Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn 
            660                 665                 670         


Gly Ile Arg Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Tyr Leu Ile 
        675                 680                 685             


Asp Asp Gly Ser Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp 
    690                 695                 700                 


Thr Leu Pro Phe Lys Gln Ile Ile Gln Lys Ser Gln Val Val Gly Asp 
705                 710                 715                 720 


Val Asp Asp Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Lys Val Met Gly Asp Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Asn Arg Gly Arg Ser Gln Ser Gln Gln Arg Leu 
    770                 775                 780                 


Lys Lys Leu Gln Asn Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn 
785                 790                 795                 800 


Glu Glu Lys Pro Ser Tyr Ile Glu Asp Lys Val Glu Asn Ser His Leu 
                805                 810                 815     


Gln Asn Asp Gln Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met 
            820                 825                 830         


Tyr Thr Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile 
        835                 840                 845             


Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn 
    850                 855                 860                 


Arg Val Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val 
865                 870                 875                 880 


Pro Ser Leu Asp Ile Val Arg Ala Arg Lys Ala Glu Trp Val Arg Leu 
                885                 890                 895     


Tyr Lys Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys 
            900                 905                 910         


Ala Glu Arg Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys 
        915                 920                 925             


Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile 
    930                 935                 940                 


Leu Asp Ala Arg Phe Asn Thr Glu Ser Asp Glu Asn Asp Lys Val Ile 
945                 950                 955                 960 


Arg Asp Val Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe 
                965                 970                 975     


Arg Lys Asp Phe Glu Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His 
            980                 985                 990         


His Ala His Asp Ala Tyr Leu Asn  Ala Val Val Gly Thr  Ala Leu Leu 
        995                 1000                 1005             


Lys Lys  Tyr Pro Lys Leu Ala  Ser Glu Phe Val Tyr  Gly Glu Tyr 
    1010                 1015                 1020             


Lys Lys  Tyr Asp Ile Arg Lys  Phe Ile Thr Asn Ser  Ser Asp Lys 
    1025                 1030                 1035             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Leu Met  Asn Phe Phe 
    1040                 1045                 1050             


Lys Arg  Val Ile Arg Tyr Ser  Asn Gly Lys Val Ile  Val Arg Pro 
    1055                 1060                 1065             


Val Val  Glu Tyr Ser Lys Asp  Thr Glu Asp Ile Ala  Trp Asp Lys 
    1070                 1075                 1080             


Lys Ser  Asn Phe Arg Thr Ile  Cys Lys Val Leu Ser  Tyr Pro Gln 
    1085                 1090                 1095             


Val Asn  Ile Val Lys Lys Val  Glu Thr Gln Thr Gly  Gly Phe Ser 
    1100                 1105                 1110             


Lys Glu  Ser Ile Leu Pro Lys  Gly Asp Ser Asp Lys  Leu Ile Pro 
    1115                 1120                 1125             


Arg Lys  Thr Lys Lys Ala Tyr  Trp Asp Thr Lys Lys  Tyr Gly Gly 
    1130                 1135                 1140             


Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val Phe Val  Val Ala Asp 
    1145                 1150                 1155             


Val Glu  Lys Gly Lys Ala Lys  Lys Leu Lys Thr Val  Lys Glu Leu 
    1160                 1165                 1170             


Val Gly  Ile Ser Ile Met Glu  Arg Ser Phe Phe Glu  Glu Asn Pro 
    1175                 1180                 1185             


Val Glu  Phe Leu Glu Asn Lys  Gly Tyr His Asn Ile  Arg Glu Asp 
    1190                 1195                 1200             


Lys Leu  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe Glu  Phe Glu Gly 
    1205                 1210                 1215             


Gly Lys  Arg Arg Leu Leu Ala  Ser Ala Ser Glu Leu  Gln Lys Gly 
    1220                 1225                 1230             


Asn Glu  Met Val Ile Pro Gly  His Leu Val Lys Leu  Leu Tyr His 
    1235                 1240                 1245             


Ala Gln  Arg Ile Asn Ser Phe  Asn Ser Thr Lys Tyr  Leu Asp Tyr 
    1250                 1255                 1260             


Val Ser  Ala His Lys Lys Glu  Phe Glu Lys Val Leu  Ser Cys Val 
    1265                 1270                 1275             


Glu Asp  Phe Ala Asn Leu Tyr  Val Asp Val Glu Lys  Asn Leu Ser 
    1280                 1285                 1290             


Lys Ile  Arg Ala Val Ala Asp  Ser Met Asp Asn Phe  Ser Ile Glu 
    1295                 1300                 1305             


Glu Ile  Ser Asn Ser Phe Ile  Asn Leu Leu Thr Leu  Thr Ala Leu 
    1310                 1315                 1320             


Gly Ala  Pro Ala Asp Phe Asn  Phe Leu Gly Glu Lys  Ile Pro Arg 
    1325                 1330                 1335             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Cys Leu Asn Ala  Thr Leu Ile 
    1340                 1345                 1350             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1355                 1360                 1365             


Lys Ile  Gly Glu Glu 
    1370             


<210> 449
<211> 1375
<212> PRT
<213> Streptococcus canis


<220>
<223> Streptococcus canis FSL Z3-227

<400> 449
Met Glu Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asn Arg Lys Ser Ile Lys Lys Asn Leu Met 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Asn Glu Met Ala Lys Leu Asp Asp Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


Asn Glu Arg His Pro Ile Phe Gly Asn Leu Ala Asp Glu Val Ala Tyr 
        115                 120                 125             


His Arg Asn Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Pro Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asn Ala 
                165                 170                 175     


Glu Asn Ser Asp Val Ala Lys Leu Phe Tyr Gln Leu Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Ser Pro Leu Asp Glu Ile Glu Val Asp Ala 
        195                 200                 205             


Lys Gly Ile Leu Ser Ala Arg Leu Ser Lys Ser Lys Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Ala Val Phe Pro Asn Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Ile Ile Ala Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Thr Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Glu Leu Leu Gly Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ser Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Ser Asn Ser Glu Val Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Asp Glu His His Gln Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Thr Leu Val Arg Gln Gln Phe Pro Glu Lys Tyr Ala Glu Ile Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ile Gly Ile Lys 
        355                 360                 365             


His Arg Lys Arg Thr Thr Lys Leu Ala Thr Gln Glu Glu Phe Tyr Lys 
    370                 375                 380                 


Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Ala Glu Glu Leu Leu 
385                 390                 395                 400 


Ala Lys Leu Asn Arg Asp Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp 
                405                 410                 415     


Asn Gly Ser Ile Pro His Gln Ile His Leu Lys Glu Leu His Ala Ile 
            420                 425                 430         


Leu Arg Arg Gln Glu Glu Phe Tyr Pro Phe Leu Lys Glu Asn Arg Glu 
        435                 440                 445             


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
    450                 455                 460                 


Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Leu Thr Arg Lys Ser Glu 
465                 470                 475                 480 


Glu Ala Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala 
                485                 490                 495     


Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Glu Gln Leu 
            500                 505                 510         


Pro Asn Lys Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe 
        515                 520                 525             


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Arg Met 
    530                 535                 540                 


Arg Lys Pro Glu Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp 
545                 550                 555                 560 


Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu 
                565                 570                 575     


Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ile Gly 
            580                 585                 590         


Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu 
        595                 600                 605             


Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp 
    610                 615                 620                 


Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu 
625                 630                 635                 640 


Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys 
                645                 650                 655     


Val Met Lys Gln Leu Lys Arg Arg His Tyr Thr Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Arg Lys Met Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr 
        675                 680                 685             


Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ser Asn Arg Asn Phe Met 
    690                 695                 700                 


Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Glu Ile Glu Lys 
705                 710                 715                 720 


Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu Gln Ile Ala Asp 
                725                 730                 735     


Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys 
            740                 745                 750         


Ile Val Asp Glu Leu Val Lys Val Met Gly His Lys Pro Glu Asn Ile 
        755                 760                 765             


Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Thr Lys Gly Leu Gln 
    770                 775                 780                 


Gln Ser Arg Glu Arg Lys Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu 
785                 790                 795                 800 


Glu Ser Gln Ile Leu Lys Glu Asn Pro Val Glu Asn Thr Gln Leu Gln 
                805                 810                 815     


Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr 
            820                 825                 830         


Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp 
        835                 840                 845             


His Ile Val Pro Gln Ser Phe Ile Lys Asp Asp Ser Ile Asp Asn Lys 
    850                 855                 860                 


Val Leu Thr Arg Ser Val Glu Asn Arg Gly Lys Ser Asp Asn Val Pro 
865                 870                 875                 880 


Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu 
                885                 890                 895     


Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
            900                 905                 910         


Glu Arg Gly Gly Leu Ser Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu 
    930                 935                 940                 


Asp Ser Arg Met Asn Thr Lys Arg Asp Lys Asn Asp Lys Pro Ile Arg 
945                 950                 955                 960 


Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg 
                965                 970                 975     


Lys Asp Phe Gln Leu Tyr Lys Val Arg Asp Ile Asn Asn Tyr His His 
            980                 985                 990         


Ala His Asp Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
        995                 1000                 1005             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1010                 1015                 1020             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1025                 1030                 1035             


Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1040                 1045                 1050             


Phe Phe  Lys Thr Glu Val Lys  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1055                 1060                 1065             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Val Val Trp 
    1070                 1075                 1080             


Asn Lys  Glu Lys Asp Phe Ala  Thr Val Arg Lys Val  Leu Ala Met 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Ser Lys Arg Glu Ser  Ala Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Lys Gly Trp  Asp Thr Arg Lys Tyr  Gly Gly Phe 
    1130                 1135                 1140             


Gly Ser  Pro Thr Val Ala Tyr  Ser Ile Leu Val Val  Ala Lys Val 
    1145                 1150                 1155             


Glu Lys  Gly Lys Ala Lys Lys  Leu Lys Ser Val Lys  Val Leu Val 
    1160                 1165                 1170             


Gly Ile  Thr Ile Met Glu Lys  Gly Ser Tyr Glu Lys  Asp Pro Ile 
    1175                 1180                 1185             


Gly Phe  Leu Glu Ala Lys Gly  Tyr Lys Asp Ile Lys  Lys Glu Leu 
    1190                 1195                 1200             


Ile Phe  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1205                 1210                 1215             


Arg Arg  Arg Met Leu Ala Ser  Ala Thr Glu Leu Gln  Lys Ala Asn 
    1220                 1225                 1230             


Glu Leu  Val Leu Pro Gln His  Leu Val Arg Leu Leu  Tyr Tyr Thr 
    1235                 1240                 1245             


Gln Asn  Ile Ser Ala Thr Thr  Gly Ser Asn Asn Leu  Gly Tyr Ile 
    1250                 1255                 1260             


Glu Gln  His Arg Glu Glu Phe  Lys Glu Ile Phe Glu  Lys Ile Ile 
    1265                 1270                 1275             


Asp Phe  Ser Glu Lys Tyr Ile  Leu Lys Asn Lys Val  Asn Ser Asn 
    1280                 1285                 1290             


Leu Lys  Ser Ser Phe Asp Glu  Gln Phe Ala Val Ser  Asp Ser Ile 
    1295                 1300                 1305             


Leu Leu  Ser Asn Ser Phe Val  Ser Leu Leu Lys Tyr  Thr Ser Phe 
    1310                 1315                 1320             


Gly Ala  Ser Gly Gly Phe Thr  Phe Leu Asp Leu Asp  Val Lys Gln 
    1325                 1330                 1335             


Gly Arg  Leu Arg Tyr Gln Thr  Val Thr Glu Val Leu  Asp Ala Thr 
    1340                 1345                 1350             


Leu Ile  Tyr Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Thr Asp 
    1355                 1360                 1365             


Leu Ser  Gln Leu Gly Gly Asp  
    1370                 1375 


<210> 450
<211> 1345
<212> PRT
<213> Streptococcus constellatus


<220>
<223> Streptococcus constellatus subsp. constellatus SK53

<400> 450
Met Gly Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Gln Ser Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Thr Gly Glu Met Asn Lys Val Asp Glu Asn 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Asp Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu His His Pro Ile Phe Gly Asn Ile Ala Ala Glu Val Lys Tyr 
        115                 120                 125             


His Asp Asp Phe Pro Thr Ile Tyr His Leu Arg Arg His Leu Ala Asp 
    130                 135                 140                 


Thr Ser Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Tyr Glu Gly Asp Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Ala Leu Phe Lys Asp Phe Val Glu Glu Tyr 
            180                 185                 190         


Asp Lys Thr Ile Glu Glu Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Ser Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala His Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Asp Leu His Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Phe Leu Gly Glu Val Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Glu Glu His Gln Lys Asp Leu Lys Lys Leu Lys 
                325                 330                 335     


Asp Phe Ile Lys Val Asn Ala Pro Asp Gln Tyr Asn Ala Ile Phe Lys 
            340                 345                 350         


Asp Lys Asn Lys Lys Gly Tyr Ala Ser Tyr Ile Glu Ser Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Gly Ile Leu Leu Lys Ile Asn 
    370                 375                 380                 


Gly Ser Gly Asp Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp 
465                 470                 475                 480 


Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Ala Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Glu Ala Lys Phe Phe Asp Thr Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Val Asn Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ser Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu 
        595                 600                 605             


Asp Asp Lys Ala Asn Glu Lys Thr Ile Glu Asp Ile Ile Gln Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Ile Phe Thr Lys Ala Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Arg Ala Gln Ile Ile Asp Asp Val Asp Asp 
705                 710                 715                 720 


Ile Ala Asn Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly His Asn Pro Ala Asn Ile Ile Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Asp Lys Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Leu Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Asn Leu Asp Asn Pro Val Asn Ile Lys Asn Val 
785                 790                 795                 800 


Glu Asn Gln Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Glu Thr Leu Asp Ile Asn Asn Leu 
            820                 825                 830         


Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp 
        835                 840                 845             


Asn Ser Leu Asp Asn Arg Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Ile Glu Val Val His Glu Met Lys Ser 
865                 870                 875                 880 


Phe Trp Ser Lys Leu Leu Ser Val Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Glu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Glu Arg Phe Asn Thr Glu Phe Asp Gly 
    930                 935                 940                 


Asn Lys Arg Arg Ile Arg Asn Val Lys Ile Ile Thr Leu Lys Ser Asn 
945                 950                 955                 960 


Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Asn Ala Leu Leu Leu Lys Tyr  Pro Gln Leu Glu Pro  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Glu Tyr Pro Lys Tyr  Asn Ser Tyr Arg Ser  Arg Lys Ser 
    1010                 1015                 1020             


Ala Thr  Glu Lys Phe Leu Phe  Tyr Ser Asn Ile Leu  Arg Phe Phe 
    1025                 1030                 1035             


Lys Lys  Glu Asp Ile Gln Thr  Asn Glu Asp Gly Glu  Ile Ala Trp 
    1040                 1045                 1050             


Asn Lys  Glu Lys His Ile Lys  Ile Leu Arg Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Glu Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Asn  Ser Tyr Trp Asp Pro  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Val  Val Ala Tyr Ser Ile  Leu Val Phe 
    1115                 1120                 1125             


Ala Asp  Val Glu Lys Gly Lys  Ser Lys Lys Leu Arg  Lys Val Gln 
    1130                 1135                 1140             


Asp Met  Val Gly Ile Thr Ile  Met Glu Lys Lys Arg  Phe Glu Lys 
    1145                 1150                 1155             


Asn Pro  Val Asp Phe Leu Glu  Gln Arg Gly Tyr Arg  Asn Val Arg 
    1160                 1165                 1170             


Leu Glu  Lys Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1175                 1180                 1185             


Glu Asn  Lys Arg Arg Arg Leu  Leu Ala Ser Ala Lys  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Leu Val Ile  Pro Gln Arg Phe Thr  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ser Tyr Arg Ile Glu  Lys Asp Tyr Glu Pro  Glu His Arg 
    1220                 1225                 1230             


Glu Tyr  Val Glu Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Glu 
    1235                 1240                 1245             


Tyr Ile  Ser Val Phe Ser Arg  Lys Tyr Val Leu Ala  Asp Asn Asn 
    1250                 1255                 1260             


Leu Thr  Lys Ile Glu Met Leu  Phe Ser Lys Asn Lys  Asp Ala Glu 
    1265                 1270                 1275             


Val Ser  Ser Leu Ala Lys Ser  Phe Ile Ser Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Phe  Gly Ala Pro Ala Ala  Phe Asn Phe Phe Gly  Glu Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Val Thr Glu Cys Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Glu Asp  
    1340                 1345 


<210> 451
<211> 1371
<212> PRT
<213> Streptococcus dysgalactiae

<400> 451
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Met Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gln 
    530                 535                 540                 


Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Lys Tyr Ala 
625                 630                 635                 640 


Asn Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Ile Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Gly  Asp 
    1370     


<210> 452
<211> 1371
<212> PRT
<213> Streptococcus dysgalactiae

<400> 452
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Lys Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Lys Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asn Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gln 
    530                 535                 540                 


Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Lys Tyr Ala 
625                 630                 635                 640 


Asn Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Ile Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Gly  Asp 
    1370     


<210> 453
<211> 1371
<212> PRT
<213> Streptococcus dysgalactiae

<400> 453
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Met Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gln 
    530                 535                 540                 


Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Lys Tyr Ala 
625                 630                 635                 640 


Asn Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Ile Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Thr Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Met Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Gly  Asp 
    1370     


<210> 454
<211> 1371
<212> PRT
<213> Streptococcus dysgalactiae

<400> 454
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Met Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gln 
    530                 535                 540                 


Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Ile Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asn Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Ile Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Gly  Asp 
    1370     


<210> 455
<211> 1348
<212> PRT
<213> Streptococcus equi

<400> 455
Met Lys Lys Pro Tyr Thr Ile Ala Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Val Val Val Thr Asp Asp Tyr Arg Val Pro Thr Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Glu Arg Lys Thr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asp Thr Ala Glu Gly Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Lys Glu Ile Phe Thr Glu Glu Met Ala Lys Val Asp Asp Gly 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Asp Ser Phe Tyr Val Leu Glu Asp Lys Glu 
            100                 105                 110         


Gly Asn Lys His Pro Ile Phe Ala Asn Leu Ala Asp Glu Val Ala Tyr 
        115                 120                 125             


His Lys Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Val Asp 
    130                 135                 140                 


Asn Pro Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Val Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Thr Leu Ser Ser 
                165                 170                 175     


Lys Asn Asn Asn Leu Gln Lys Ser Phe Asp His Leu Val Asp Thr Tyr 
            180                 185                 190         


Asn Leu Leu Phe Glu Glu Gln Arg Leu Leu Thr Glu Gly Ile Asn Ala 
        195                 200                 205             


Lys Glu Leu Leu Ser Ala Ala Leu Ser Lys Ser Lys Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ser Leu Ile Pro Gly Gln Lys Lys Thr Gly Ile Phe Gly Asn 
225                 230                 235                 240 


Ile Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ala Asn Phe 
                245                 250                 255     


Gly Leu Ser Lys Asp Val Lys Leu Gln Leu Ala Lys Asp Thr Tyr Ala 
            260                 265                 270         


Asp Asp Leu Asp Ser Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Thr Glu Ser Asp Glu Ile Thr Arg Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Arg Glu His His Lys Asp Leu Val Thr Leu Lys 
                325                 330                 335     


Thr Leu Ile Lys Asp Gln Leu Pro Glu Lys Tyr Gln Glu Ile Phe Leu 
            340                 345                 350         


Asp Lys Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Gly Gln Val Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Tyr Leu Lys Pro Ile Leu Ala Arg Leu Asp 
    370                 375                 380                 


Gly Ser Glu Pro Leu Leu Leu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Glu Glu Leu His Ala Ile Leu Arg Arg Gln Glu Val Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Lys Lys Ile Glu Ser Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly His Ser Arg Phe Ala Trp 
    450                 455                 460                 


Val Lys Arg Lys Phe Asp Gly Ala Ile Arg Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Ile Val Asp Glu Glu Ala Ser Ala Gln Ile Phe Ile Glu Lys Met Thr 
                485                 490                 495     


Lys Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Ala Thr Glu Gly Met Thr Arg Pro Gln Phe Leu Ser Ala Asp Gln 
    530                 535                 540                 


Lys Gln Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asn Tyr Phe Lys Lys Ile Glu Cys Trp Asp 
                565                 570                 575     


Ser Val Glu Ile Thr Gly Val Glu Asp Ser Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Gln Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Pro Asp Asn Gln Lys Ile Ile Glu Asp Ile Ile Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Lys Met Ile Ser Lys Arg Leu Asp Gln Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Lys Val Val Leu Asn Lys Leu Glu Arg His His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Gly Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ala Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Ser Glu Leu Ser Phe 
    690                 695                 700                 


Ile Asp Glu Ile Ala Lys Ala Gln Val Ile Gly Lys Thr Glu Tyr Ser 
705                 710                 715                 720 


Lys Asp Leu Val Gly Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Ser Gln Thr Ile Lys Ile Val Asp Glu Leu Val Lys Ile Met Gly 
            740                 745                 750         


Tyr Leu Pro Gln Gln Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Gln Gly Ile Lys Asn Ala Arg Gln Arg Met Arg Lys Leu Glu 
    770                 775                 780                 


Glu Thr Ala Lys Lys Leu Gly Ser Asn Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Asp Asn Ser Gln Leu Gln Asn Asp Lys Arg Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Asp Asp Leu Asp Ile Asp Tyr Leu 
            820                 825                 830         


Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe Ile Lys Asn 
        835                 840                 845             


Asn Ser Ile Asp Asn Lys Val Leu Thr Ser Gln Gly Ala Asn Arg Gly 
    850                 855                 860                 


Lys Leu Asp Asn Val Pro Ser Glu Ala Ile Val Arg Lys Met Lys Gly 
865                 870                 875                 880 


Tyr Trp Gln Ser Leu Leu Arg Ala Gly Ala Ile Ser Lys Gln Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Gln Val Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Phe Asn Thr Glu Phe Asp Asp 
    930                 935                 940                 


His Asn Lys Arg Ile Arg Lys Val His Ile Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Glu Phe Gly Leu Tyr Lys Ile Arg Asp 
                965                 970                 975     


Ile Asn His Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Ala Lys Ala Ile Leu Gly Lys Tyr  Pro Gln Leu Ala Pro  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Pro Lys Tyr  Asn Ser Phe Lys Glu  Arg Gln Lys 
    1010                 1015                 1020             


Ala Thr  Gln Lys Met Leu Phe  Tyr Ser Asn Ile Leu  Lys Phe Phe 
    1025                 1030                 1035             


Lys Asp  Gln Glu Ser Leu His  Val Asn Ser Asp Gly  Glu Glu Ile 
    1040                 1045                 1050             


Trp Asn  Ala Asn Lys His Leu  Pro Ile Ile Lys Asn  Val Leu Ser 
    1055                 1060                 1065             


Ile Pro  Gln Val Asn Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly 
    1070                 1075                 1080             


Gly Phe  Tyr Lys Glu Ser Ile  Leu Ser Lys Gly Asn  Ser Asp Lys 
    1085                 1090                 1095             


Leu Ile  Pro Arg Lys Asn Asn  Trp Asp Thr Arg Lys  Tyr Gly Gly 
    1100                 1105                 1110             


Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val Leu Val  Ile Ala Lys 
    1115                 1120                 1125             


Met Glu  Lys Gly Lys Ala Lys  Val Leu Lys Pro Val  Lys Glu Met 
    1130                 1135                 1140             


Val Gly  Ile Thr Ile Met Glu  Arg Thr Ala Phe Glu  Glu Asn Pro 
    1145                 1150                 1155             


Val Val  Phe Leu Glu Ala Arg  Gly Tyr Arg Glu Ile  Gln Glu His 
    1160                 1165                 1170             


Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn 
    1175                 1180                 1185             


Gly Arg  Arg Arg Leu Leu Ala  Ser Ala Ser Glu Leu  Gln Lys Gly 
    1190                 1195                 1200             


Asn Glu  Leu Phe Leu Pro Val  Asp Tyr Met Thr Phe  Leu Tyr Leu 
    1205                 1210                 1215             


Ala Ala  His Tyr His Glu Leu  Thr Gly Ser Ser Glu  Asp Val Leu 
    1220                 1225                 1230             


Arg Lys  Lys Tyr Phe Val Asp  Arg His Leu His Tyr  Phe Asp Asp 
    1235                 1240                 1245             


Ile Ile  Gln Met Ile Asn Asp  Phe Ala Glu Arg His  Ile Leu Ala 
    1250                 1255                 1260             


Ser Ser  Asn Leu Glu Lys Ile  Asn His Thr Tyr His  Asn Asn Ser 
    1265                 1270                 1275             


Asp Leu  Pro Val Asn Glu Arg  Ala Glu Asn Ile Ile  Asn Val Phe 
    1280                 1285                 1290             


Thr Phe  Val Ala Leu Gly Ala  Pro Ala Ala Phe Lys  Phe Phe Asp 
    1295                 1300                 1305             


Ala Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu 
    1310                 1315                 1320             


Asn Ala  Thr Leu Ile His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr 
    1325                 1330                 1335             


Arg Ile  Asp Leu Ser Gln Leu  Gly Glu Asn 
    1340                 1345             


<210> 456
<211> 1377
<212> PRT
<213> Streptococcus equinus


<220>
<223> Streptococcus equinus ATCC 9812

<400> 456
Met Glu Lys Thr Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Ala Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Lys Glu Met Ala Lys Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Glu Ser Phe Leu Thr Asp Asp Asp Lys Thr 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Thr Tyr 
        115                 120                 125             


His Gln Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Ile Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ala Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Lys Gln Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Val Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Ala Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Glu Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Thr Phe Ile Lys Val Asn Asn Phe Asp Lys Tyr His Glu Ile Phe Lys 
            340                 345                 350         


Asp Lys Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Ile Phe Tyr Lys His Leu Lys Ser Ile Ile Ser Glu Lys Asn 
    370                 375                 380                 


Gly Gly Gln Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Thr Ile Leu Arg Arg Gln Gly Glu Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Ala Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Lys Tyr His Ser Asp Glu Pro Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Val Val Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Tyr Val Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Lys Ser Phe Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Ala Lys Leu Leu Ser Tyr Leu Asn Asn Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Asn Asp Leu Ile Gly Leu Asp Lys Asp Ser Lys Ser Phe Asn Ala Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ser Phe Leu 
        595                 600                 605             


Asp Asp Lys Thr Asn Glu Gln Ile Ile Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Asp Met Ile His Glu Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Ile Phe Thr Ser Gln Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Phe Leu Ile Asp Asp Gly 
        675                 680                 685             


Asp Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser 
    690                 695                 700                 


Phe Lys Thr Thr Ile Gln Glu Ala Gln Val Val Gly Asp Val Asp Asp 
705                 710                 715                 720 


Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly His Asn Pro Gln Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Ile Thr Gly Tyr Gly Arg Asn Arg Ser Asn Gln Arg Leu Lys Arg Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Glu Phe Gly Ser Asp Ile Leu Ser Lys Lys Lys 
785                 790                 795                 800 


Pro Ser Tyr Val Asp Ser Lys Val Glu Asn Ser His Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Glu Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val Leu 
    850                 855                 860                 


Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile 
865                 870                 875                 880 


Glu Ile Val Arg Asn Arg Lys Ser Tyr Trp Tyr Lys Leu Tyr Lys Ser 
                885                 890                 895     


Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Thr Glu Thr Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala 
    930                 935                 940                 


Arg Phe Asn Thr Lys Cys Asp Glu Asn Asp Lys Val Ile Arg Asp Val 
945                 950                 955                 960 


Lys Val Ile Thr Leu Lys Ser Ser Leu Val Ser Gln Phe Arg Lys Glu 
                965                 970                 975     


Phe Lys Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Val  Gly Thr Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Ala Pro Glu Phe  Val Tyr Gly Glu Tyr  Lys Lys Tyr 
    1010                 1015                 1020             


Asp Val  Arg Lys Leu Val Ala  Lys Ser Ser Asp Asn  His Ser Glu 
    1025                 1030                 1035             


Leu Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe Tyr Ser  Asn Leu Met 
    1040                 1045                 1050             


Asn Phe  Phe Lys Thr Glu Val  Lys Tyr Ala Asp Gly  Arg Val Phe 
    1055                 1060                 1065             


Glu Arg  Pro Asp Ile Glu Thr  Asn Ala Asp Gly Glu  Val Val Trp 
    1070                 1075                 1080             


Asn Lys  Gln Arg Asp Phe Asn  Ile Val Arg Lys Val  Leu Ser Tyr 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Val Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Thr Lys Lys  Leu Gln Trp Glu Thr  Gln Lys Tyr 
    1130                 1135                 1140             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1145                 1150                 1155             


Ala Asp  Val Glu Lys Gly Lys  Thr Arg Lys Leu Lys  Thr Val Lys 
    1160                 1165                 1170             


Glu Leu  Val Gly Ile Ser Ile  Met Glu Arg Ser Ser  Phe Glu Glu 
    1175                 1180                 1185             


Asn Pro  Val Ser Phe Leu Glu  Lys Lys Gly Tyr His  Asn Val Gln 
    1190                 1195                 1200             


Glu Asp  Lys Leu Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Phe 
    1205                 1210                 1215             


Glu Gly  Gly Arg Arg Arg Leu  Leu Ala Ser Ala Thr  Glu Leu Gln 
    1220                 1225                 1230             


Lys Gly  Asn Glu Val Val Leu  Pro Gln Tyr Met Val  Asn Leu Leu 
    1235                 1240                 1245             


Tyr His  Ser Gln His Val Asn  Asn Ser His Lys Pro  Glu His Leu 
    1250                 1255                 1260             


Asn Tyr  Val Lys Gln His Lys  Asp Glu Phe Lys Asp  Ile Phe Asn 
    1265                 1270                 1275             


Leu Ile  Ile Ser Ile Ala Arg  Ile Asn Ile Leu Lys  Pro Lys Val 
    1280                 1285                 1290             


Val Asp  Asn Leu Ile Asn Glu  Phe Thr Glu Tyr Gly  Gln Glu Asp 
    1295                 1300                 1305             


Ile Ser  Ser Leu Ser Glu Ser  Phe Ile Asn Leu Leu  Lys Phe Ile 
    1310                 1315                 1320             


Ser Phe  Gly Ala Pro Gly Ala  Phe Lys Phe Leu Lys  Leu Asp Val 
    1325                 1330                 1335             


Lys Gln  Ser Asn Leu Arg Tyr  Lys Ser Thr Thr Glu  Ala Leu Ser 
    1340                 1345                 1350             


Ala Thr  Leu Ile His Gln Ser  Val Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Ser Lys Leu Gly  Glu Glu 
    1370                 1375         


<210> 457
<211> 1370
<212> PRT
<213> Streptococcus gallolyticus

<400> 457
Met Thr Lys Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Thr Lys Val Asp Glu 
                85                  90                  95      


Ser Phe Phe Tyr Arg Leu Asp Glu Ser Phe Leu Thr Thr Asp Glu Lys 
            100                 105                 110         


Asp Phe Glu Arg His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala 
        115                 120                 125             


Tyr His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Asn Tyr Leu Ala 
    130                 135                 140                 


Asp Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asn 
                165                 170                 175     


Ala Glu Asn Thr Asp Val Gln Lys Leu Phe Thr Asp Phe Val Gly Val 
            180                 185                 190         


Tyr Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp 
        195                 200                 205             


Val Ala Ser Thr Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu 
    210                 215                 220                 


Asn Leu Ile Lys Tyr Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Met Asn 
                245                 250                 255     


Phe Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Glu Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala 
        275                 280                 285             


Asp Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Lys Arg Tyr Val Glu His His Glu Asp Leu Glu Lys Leu 
                325                 330                 335     


Lys Glu Phe Ile Lys Ala Asn Lys Ser Glu Leu Tyr His Asp Ile Phe 
            340                 345                 350         


Lys Asp Lys Asn Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val 
        355                 360                 365             


Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile 
    370                 375                 380                 


Asp Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Lys Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Val Arg Lys Asp Ser Arg Phe Ala 
    450                 455                 460                 


Trp Ala Glu Tyr Arg Ser Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp 
465                 470                 475                 480 


Lys Val Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met 
                485                 490                 495     


Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser His Val Tyr Glu Thr Tyr Ala Val Tyr Asn Glu Leu Thr Lys Ile 
        515                 520                 525             


Lys Tyr Val Asn Glu Gln Gly Lys Glu Ser Phe Phe Asp Ser Asn Met 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr 
545                 550                 555                 560 


Lys Glu Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu Tyr Arg 
                565                 570                 575     


Ile Lys Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ala Phe 
        595                 600                 605             


Leu Asp Asp Lys Val Asn Glu Glu Val Ile Glu Asp Ile Ile Lys Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Lys Asp Met Ile His Glu Arg Leu Gln Lys 
625                 630                 635                 640 


Tyr Ser Asp Ile Phe Thr Ala Asn Gln Leu Lys Lys Leu Glu Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Ser Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Thr Leu 
    690                 695                 700                 


Pro Phe Lys Gln Ile Ile Gln Lys Ser Gln Val Val Gly Asp Val Asp 
705                 710                 715                 720 


Asp Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Asp Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Arg Gly Arg Ser Gln Ser Gln Gln Arg Leu Lys Lys 
    770                 775                 780                 


Leu Gln Ser Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn Glu Glu 
785                 790                 795                 800 


Lys Pro Ser Tyr Ile Glu Asp Lys Val Glu Asn Ser His Leu Gln Asn 
                805                 810                 815     


Asp Gln Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr 
            820                 825                 830         


Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile Asp His 
        835                 840                 845             


Ile Ile Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val 
    850                 855                 860                 


Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser 
865                 870                 875                 880 


Leu Asp Ile Val Arg Ala Arg Lys Ala Glu Trp Val Arg Leu Tyr Lys 
                885                 890                 895     


Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ala Arg Phe Asn Thr Glu His Asp Glu Asn Asp Lys Val Ile Arg Asp 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys 
                965                 970                 975     


Asp Phe Glu Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Lys Leu Ala Ser Glu  Phe Val Tyr Gly Glu  Tyr Lys Lys 
    1010                 1015                 1020             


Tyr Asp  Ile Arg Lys Phe Ile  Thr Asn Ser Ser Asp  Lys Ala Thr 
    1025                 1030                 1035             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Thr 
    1040                 1045                 1050             


Lys Val  Lys Tyr Ala Asp Gly  Thr Val Phe Glu Arg  Pro Ile Ile 
    1055                 1060                 1065             


Glu Thr  Asn Ala Asp Gly Glu  Ile Ala Trp Asn Lys  Gln Ile Asp 
    1070                 1075                 1080             


Phe Glu  Lys Val Arg Lys Val  Leu Ser Tyr Pro Gln  Val Asn Ile 
    1085                 1090                 1095             


Val Lys  Lys Val Glu Thr Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1100                 1105                 1110             


Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu Ile Pro  Arg Lys Thr 
    1115                 1120                 1125             


Lys Lys  Val Tyr Trp Asp Thr  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1130                 1135                 1140             


Pro Thr  Val Ala Tyr Ser Val  Phe Val Val Ala Asp  Val Glu Lys 
    1145                 1150                 1155             


Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys Glu Leu  Val Gly Ile 
    1160                 1165                 1170             


Ser Ile  Met Glu Arg Ser Phe  Phe Glu Glu Asn Pro  Val Glu Phe 
    1175                 1180                 1185             


Leu Glu  Asn Lys Gly Tyr His  Asn Ile Arg Glu Asp  Lys Leu Ile 
    1190                 1195                 1200             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Phe Glu Gly  Gly Arg Arg 
    1205                 1210                 1215             


Arg Leu  Leu Ala Ser Ala Ser  Glu Leu Gln Lys Gly  Asn Glu Met 
    1220                 1225                 1230             


Val Leu  Pro Gly Tyr Leu Val  Glu Leu Leu Tyr His  Ala His Arg 
    1235                 1240                 1245             


Ala Asp  Asn Phe Asn Ser Thr  Glu Tyr Leu Asn Tyr  Val Ser Glu 
    1250                 1255                 1260             


His Lys  Lys Glu Phe Glu Lys  Val Leu Ser Cys Val  Glu Asp Phe 
    1265                 1270                 1275             


Ala Asn  Leu Tyr Val Asp Val  Glu Lys Asn Leu Ser  Lys Ile Arg 
    1280                 1285                 1290             


Ala Val  Ala Asp Ser Met Asp  Asn Phe Ser Ile Glu  Glu Ile Ser 
    1295                 1300                 1305             


Asn Ser  Phe Ile Asn Leu Leu  Thr Leu Thr Ala Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Asp  Phe Asn Phe Leu Gly  Glu Lys Ile Pro Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Cys Leu  Thr Ala Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1355                 1360                 1365             


Glu Glu  
    1370 


<210> 458
<211> 1370
<212> PRT
<213> Streptococcus gallolyticus


<220>
<223> Streptococcus gallolyticus subsp. gallolyticus TX20005

<400> 458
Met Thr Lys Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Thr Lys Val Asp Glu 
                85                  90                  95      


Ser Phe Phe Tyr Arg Leu Asp Glu Ser Phe Leu Thr Thr Asp Glu Lys 
            100                 105                 110         


Asp Phe Glu Arg His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala 
        115                 120                 125             


Tyr His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Asn Tyr Leu Ala 
    130                 135                 140                 


Asp Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asn 
                165                 170                 175     


Ala Glu Asn Thr Asp Val Gln Lys Leu Phe Thr Asp Phe Val Gly Val 
            180                 185                 190         


Tyr Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp 
        195                 200                 205             


Val Ala Ser Thr Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu 
    210                 215                 220                 


Asn Leu Ile Lys Tyr Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Met Asn 
                245                 250                 255     


Phe Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Glu Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala 
        275                 280                 285             


Asp Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Lys Arg Tyr Val Glu His His Glu Asp Leu Glu Lys Leu 
                325                 330                 335     


Lys Glu Phe Ile Lys Ala Asn Lys Ser Glu Leu Tyr His Asp Ile Phe 
            340                 345                 350         


Lys Asp Lys Asn Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val 
        355                 360                 365             


Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile 
    370                 375                 380                 


Asp Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Lys Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Val Arg Lys Asp Ser Arg Phe Ala 
    450                 455                 460                 


Trp Ala Glu Tyr Arg Ser Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp 
465                 470                 475                 480 


Lys Val Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met 
                485                 490                 495     


Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser His Val Tyr Glu Thr Tyr Ala Val Tyr Asn Glu Leu Thr Lys Ile 
        515                 520                 525             


Lys Tyr Val Asn Glu Gln Gly Lys Glu Ser Phe Phe Asp Ser Asn Met 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr 
545                 550                 555                 560 


Lys Glu Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu Tyr Arg 
                565                 570                 575     


Ile Lys Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ala Phe 
        595                 600                 605             


Leu Asp Asp Lys Val Asn Glu Glu Val Ile Glu Asp Ile Ile Lys Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Lys Asp Met Ile His Glu Arg Leu Gln Lys 
625                 630                 635                 640 


Tyr Ser Asp Ile Phe Thr Ala Asn Gln Leu Lys Lys Leu Glu Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Ser Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Thr Leu 
    690                 695                 700                 


Pro Phe Lys Gln Ile Ile Gln Lys Ser Gln Val Val Gly Asp Val Asp 
705                 710                 715                 720 


Asp Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Asp Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Arg Gly Arg Ser Gln Ser Gln Gln Arg Leu Lys Lys 
    770                 775                 780                 


Leu Gln Ser Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn Glu Glu 
785                 790                 795                 800 


Lys Pro Ser Tyr Ile Glu Asp Lys Val Glu Asn Ser His Leu Gln Asn 
                805                 810                 815     


Asp Gln Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr 
            820                 825                 830         


Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile Asp His 
        835                 840                 845             


Ile Ile Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val 
    850                 855                 860                 


Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser 
865                 870                 875                 880 


Leu Asp Ile Val Arg Ala Arg Lys Ala Glu Trp Val Arg Leu Tyr Lys 
                885                 890                 895     


Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ala Arg Phe Asn Thr Glu His Asp Glu Asn Asp Lys Val Ile Arg Asp 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys 
                965                 970                 975     


Asp Phe Glu Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Lys Leu Ala Ser Glu  Phe Val Tyr Gly Glu  Tyr Lys Lys 
    1010                 1015                 1020             


Tyr Asp  Ile Arg Lys Phe Ile  Thr Asn Ser Ser Asp  Lys Ala Thr 
    1025                 1030                 1035             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Thr 
    1040                 1045                 1050             


Lys Val  Lys Tyr Ala Asp Gly  Thr Val Phe Glu Arg  Pro Ile Ile 
    1055                 1060                 1065             


Glu Thr  Asn Ala Asp Gly Glu  Ile Ala Trp Asn Lys  Gln Ile Asp 
    1070                 1075                 1080             


Phe Glu  Lys Val Arg Lys Val  Leu Ser Tyr Pro Gln  Val Asn Ile 
    1085                 1090                 1095             


Val Lys  Lys Val Glu Thr Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1100                 1105                 1110             


Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu Ile Pro  Arg Lys Thr 
    1115                 1120                 1125             


Lys Lys  Val Tyr Trp Asp Thr  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1130                 1135                 1140             


Pro Thr  Val Ala Tyr Ser Val  Phe Val Val Ala Asp  Val Glu Lys 
    1145                 1150                 1155             


Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys Glu Leu  Val Gly Ile 
    1160                 1165                 1170             


Ser Ile  Met Glu Arg Ser Phe  Phe Glu Glu Asn Pro  Val Glu Phe 
    1175                 1180                 1185             


Leu Glu  Asn Lys Gly Tyr His  Asn Ile Arg Glu Asp  Lys Leu Ile 
    1190                 1195                 1200             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Phe Glu Gly  Gly Arg Arg 
    1205                 1210                 1215             


Arg Leu  Leu Ala Ser Ala Ser  Glu Leu Gln Lys Gly  Asn Glu Met 
    1220                 1225                 1230             


Val Leu  Pro Gly Tyr Leu Val  Glu Leu Leu Tyr His  Ala His Arg 
    1235                 1240                 1245             


Ala Asp  Asn Phe Asn Ser Thr  Glu Tyr Leu Asn Tyr  Val Ser Glu 
    1250                 1255                 1260             


His Lys  Lys Glu Phe Glu Lys  Val Leu Ser Cys Val  Glu Asp Phe 
    1265                 1270                 1275             


Ala Asn  Leu Tyr Val Asp Val  Glu Lys Asn Leu Ser  Lys Ile Arg 
    1280                 1285                 1290             


Ala Val  Ala Asp Ser Met Asp  Asn Phe Ser Ile Glu  Glu Ile Ser 
    1295                 1300                 1305             


Asn Ser  Phe Ile Asn Leu Leu  Thr Leu Thr Ala Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Asp  Phe Asn Phe Leu Gly  Glu Lys Ile Pro Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Cys Leu  Thr Ala Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1355                 1360                 1365             


Glu Glu  
    1370 


<210> 459
<211> 1371
<212> PRT
<213> Streptococcus gallolyticus

<400> 459
Met Thr Glu Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Asn Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ala Lys Val Asp Glu 
                85                  90                  95      


Ser Phe Phe Tyr Arg Leu Asp Glu Ser Phe Leu Thr Thr Asp Asp Lys 
            100                 105                 110         


Asp Phe Glu Arg His Pro Ile Phe Gly Asn Lys Ala Asp Glu Ile Lys 
        115                 120                 125             


Tyr His Gln Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser His Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn 
                165                 170                 175     


Ala Glu Asn Thr Asp Val Gln Lys Leu Phe Glu Ala Phe Val Glu Val 
            180                 185                 190         


Tyr Asp Arg Thr Phe Asp Asp Ser Asn Leu Ser Glu Ile Thr Val Asp 
        195                 200                 205             


Ala Ser Ser Ile Leu Thr Glu Lys Phe Ser Lys Ser Arg Arg Leu Glu 
    210                 215                 220                 


Asn Leu Ile Lys His Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly 
225                 230                 235                 240 


Asn Leu Val Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Ser 
                245                 250                 255     


Phe Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Glu Glu Asp Leu Glu Glu Leu Ile Gly Lys Ile Gly Asp Glu Tyr Ala 
        275                 280                 285             


Asp Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ala Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Lys Arg Tyr Asn Glu His Gln Val Asp Leu Lys Lys Leu 
                325                 330                 335     


Lys Glu Phe Ile Lys Asn Asn Ala Ser Asp Lys Tyr Asp Glu Ile Phe 
            340                 345                 350         


Asn Asp Lys Asp Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val 
        355                 360                 365             


Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Thr Thr Leu Ser Lys Ile 
    370                 375                 380                 


Asp Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Ala 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Ala Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala 
    450                 455                 460                 


Trp Ala Glu Tyr His Ser Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp 
465                 470                 475                 480 


Glu Ile Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met 
                485                 490                 495     


Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Val Tyr Glu Thr Tyr Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Tyr Val Asn Glu Gln Gly Lys Ser Asn Phe Phe Asp Ala Asn Met 
    530                 535                 540                 


Lys Gln Glu Ile Phe Glu His Val Phe Lys Glu Asn Arg Lys Val Thr 
545                 550                 555                 560 


Lys Asp Lys Phe Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu Tyr Arg 
                565                 570                 575     


Ile Gln Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ser Phe 
        595                 600                 605             


Leu Asp Asp Lys Thr Asn Glu Thr Ile Ile Glu Asp Ile Ile Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Asp Met Ile Arg Gln Arg Leu Gln Lys 
625                 630                 635                 640 


Tyr Ser Asp Ile Phe Thr Pro Gln Gln Leu Lys Lys Leu Glu Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asn Lys Glu Asn Gly Lys Ser Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Ser Asp Asp Thr Leu 
    690                 695                 700                 


Pro Phe Lys Gln Ile Ile Lys Asp Ala Gln Ile Ile Gly Asp Ile Asp 
705                 710                 715                 720 


Asp Val Thr Ser Val Val Arg Glu Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly His Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Arg Gly Arg Asn Gln Ser Gln Gln Arg Leu Lys Lys 
    770                 775                 780                 


Leu Gln Asp Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn Glu Glu 
785                 790                 795                 800 


Lys Pro Ser Tyr Ile Glu Gly Lys Val Glu Asn Asn His Leu Gln Asp 
                805                 810                 815     


Asp Arg Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr 
            820                 825                 830         


Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile Asp His 
        835                 840                 845             


Ile Ile Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val 
    850                 855                 860                 


Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser 
865                 870                 875                 880 


Leu Asp Ile Val His Asp Arg Lys Ala Asp Trp Ile Arg Leu Tyr Lys 
                885                 890                 895     


Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Thr Glu Asn Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ser Arg Phe Asn Thr Glu Arg Asp Glu Asn Asp Lys Val Ile Arg Asn 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys 
                965                 970                 975     


Asp Phe Lys Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Lys Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Lys Lys 
    1010                 1015                 1020             


Tyr Asp  Ile Arg Lys Phe Ile  Thr Ser Ser Gly Asp  Lys Ala Thr 
    1025                 1030                 1035             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Arg 
    1040                 1045                 1050             


Val Ile  Arg Tyr Ser Asn Gly  Lys Val Val Val Arg  Pro Val Ile 
    1055                 1060                 1065             


Glu Cys  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Gln Thr 
    1070                 1075                 1080             


Asp Phe  Glu Lys Val Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Val Glu Thr  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Pro Lys Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Lys Phe Arg Trp Asp  Thr Pro Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Asn Ile Ala Tyr Ser  Val Phe Val Ile Ala  Asp Val Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ala Lys Lys Leu  Lys Thr Val Lys Glu  Leu Val Gly 
    1160                 1165                 1170             


Ile Ser  Ile Met Glu Arg Ser  Ser Phe Glu Glu Asn  Pro Val Val 
    1175                 1180                 1185             


Phe Leu  Glu Lys Lys Gly Tyr  Gln Asn Val Gln Glu  Asp Asn Leu 
    1190                 1195                 1200             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Phe Glu  Gly Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Ser Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Val Val  Leu Ser Arg His Leu  Val Glu Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Arg Val  Asn Ser Phe Asn Asn  Ser Glu His Leu Lys  Tyr Val Ser 
    1250                 1255                 1260             


Glu His  Lys Lys Glu Phe Gly  Glu Val Leu Ser Cys  Val Glu Asn 
    1265                 1270                 1275             


Phe Ala  Lys Ser Tyr Val Asp  Val Glu Lys Asn Leu  Gly Lys Ile 
    1280                 1285                 1290             


Arg Ala  Val Ala Asp Lys Ile  Asp Thr Phe Ser Ile  Glu Asp Ile 
    1295                 1300                 1305             


Ser Ile  Ser Phe Val Asn Leu  Leu Thr Leu Thr Ala  Leu Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Asn Phe Leu  Gly Glu Lys Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Thr  Ser Thr Lys Glu Cys  Leu Asn Ala Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1355                 1360                 1365             


Gly Glu  Glu 
    1370     


<210> 460
<211> 1130
<212> PRT
<213> Streptococcus gallolyticus

<400> 460
Met Thr Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Glu Ala Lys Thr Gly Lys Val Val His Ala Asn 
            20                  25                  30          


Ser Arg Leu Phe Ser Ala Ala Asn Ala Glu Asn Asn Ala Glu Arg Arg 
        35                  40                  45              


Gly Phe Arg Gly Ser Arg Arg Leu Asn Arg Arg Lys Lys His Arg Val 
    50                  55                  60                  


Lys Arg Val Arg Asp Leu Phe Glu Lys Tyr Glu Ile Val Thr Asp Phe 
65                  70                  75                  80  


Arg Asn Leu Asn Leu Asn Pro Tyr Glu Leu Arg Val Lys Gly Leu Thr 
                85                  90                  95      


Glu Gln Leu Thr Asn Glu Glu Leu Phe Ala Ala Leu Arg Thr Ile Ser 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Thr 
        115                 120                 125             


Gly Ser Thr Asp Tyr Ala Lys Ser Ile Asp Glu Asn Arg Arg Leu Leu 
    130                 135                 140                 


Lys Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Leu Glu Lys Tyr 
145                 150                 155                 160 


Gly Gln Leu Arg Gly Asn Phe Thr Val Tyr Asp Glu Asn Gly Glu Ala 
                165                 170                 175     


His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Glu Lys Glu Ala 
            180                 185                 190         


Arg Lys Ile Leu Glu Thr Gln Ala Asp Tyr Asn Lys Lys Ile Thr Ala 
        195                 200                 205             


Glu Phe Ile Asp Asp Tyr Val Glu Ile Leu Thr Gln Lys Arg Lys Tyr 
    210                 215                 220                 


Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg Phe 
225                 230                 235                 240 


Arg Thr Asp Gly Thr Thr Leu Glu Asn Ile Phe Gly Ile Leu Ile Gly 
                245                 250                 255     


Lys Cys Ser Phe Tyr Pro Asp Glu Tyr Arg Ala Ser Lys Ala Ser Tyr 
            260                 265                 270         


Thr Ala Gln Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Lys Val 
        275                 280                 285             


Pro Thr Glu Thr Gly Lys Leu Ser Thr Glu Gln Lys Glu Ala Leu Val 
    290                 295                 300                 


Glu Phe Ala Lys Ser Thr Ala Thr Leu Gly Pro Ala Lys Leu Leu Lys 
305                 310                 315                 320 


Glu Ile Ala Lys Ile Leu Asp Cys Lys Val Asp Glu Ile Lys Gly Tyr 
                325                 330                 335     


Arg Glu Asp Asp Lys Gly Lys Pro Asp Leu His Thr Phe Glu Pro Tyr 
            340                 345                 350         


Arg Lys Leu Lys Phe Asn Leu Asp Ser Val Asn Ile Asp Asp Leu Ser 
        355                 360                 365             


Arg Glu Val Leu Asp Lys Leu Ala Asp Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Asp Ala Ile Arg His Asn Leu Pro Asn Gln Phe 
385                 390                 395                 400 


Thr Glu Gly Gln Ile Ser Glu Ile Ile Lys Val Arg Lys Ser Gln Ser 
                405                 410                 415     


Thr Ala Phe Asn Lys Gly Trp His Ser Phe Ser Ala Lys Leu Met Asn 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Ala Thr Ser Asp Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Glu Lys Phe Lys Val Asn Lys Lys Ser Ser Lys Asn 
    450                 455                 460                 


Thr Lys Thr Ile Asp Glu Lys Glu Val Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Thr Ile Lys Ile Ile Asn Ala Ala 
                485                 490                 495     


Val Lys Lys Tyr Gly Asp Phe Asp Lys Ile Val Ile Glu Met Pro Arg 
            500                 505                 510         


Asp Lys Asn Ala Asp Asp Glu Lys Lys Phe Ile Asp Lys Arg Asn Lys 
        515                 520                 525             


Glu Asn Lys Lys Glu Lys Asp Asp Ala Leu Lys Arg Ala Ala Tyr Leu 
    530                 535                 540                 


Tyr Asn Gly Thr Asp Lys Leu Pro Asp Glu Val Phe His Gly Asn Lys 
545                 550                 555                 560 


Gln Leu Glu Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Ser Gly Lys Pro Ile Pro Ile Gln Glu Leu Val His Asn Ser 
            580                 585                 590         


Asn Asn Phe Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Trp Thr Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Lys Thr Pro Tyr Gln Val Ile Asp Ser Met Asp Ala Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Met Lys Asp Tyr Val Leu Lys Gln Lys Gly Leu 
                645                 650                 655     


Gly Lys Lys Lys Arg Asp Tyr Leu Leu Thr Thr Glu Asn Ile Asp Lys 
            660                 665                 670         


Ile Glu Val Lys Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ser Leu Gln Ser Ala Leu Arg Glu 
    690                 695                 700                 


Leu Gly Lys Asp Thr Lys Ile Ser Val Ile Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg Lys Trp Lys Ile Asp Lys Ser Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Lys 
            740                 745                 750         


Leu Trp Glu Lys Gln Asp Asn Pro Met Phe Val Asp Tyr Gly Asn Asn 
        755                 760                 765             


Gln Val Val Asp Lys Gln Thr Gly Glu Ile Leu Ser Val Ser Asp Asp 
    770                 775                 780                 


Glu Tyr Lys Glu Leu Val Phe Gln Pro Pro Tyr Gln Gly Phe Val Asn 
785                 790                 795                 800 


Met Ile Ser Ser Lys Gly Phe Glu Asp Glu Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Tyr Asn Arg Lys Val Ser Asp Ala Thr Ile Tyr Ser 
            820                 825                 830         


Thr Arg Lys Ala Lys Ile Gly Lys Asp Lys Lys Glu Glu Thr Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gln Asn Gly Phe Asp Thr Phe 
    850                 855                 860                 


Ile Lys Lys Tyr Asn Lys Asp Lys Thr Gln Phe Leu Met Tyr Gln Lys 
865                 870                 875                 880 


Asp Pro Leu Thr Trp Glu Asn Val Ile Glu Val Ile Leu Arg Asp Tyr 
                885                 890                 895     


Pro Thr Thr Lys Lys Ser Glu Asp Gly Lys Asn Asp Val Lys Cys Asn 
            900                 905                 910         


Pro Phe Glu Glu Tyr Arg Arg Glu Asn Gly Leu Val Cys Lys Tyr Ser 
        915                 920                 925             


Lys Lys Gly Lys Gly Thr Pro Ile Lys Ser Leu Lys Tyr Tyr Asp Lys 
    930                 935                 940                 


Lys Leu Gly Asn Cys Ile Asp Ile Thr Pro Glu Gly Ser Lys Asn Glu 
945                 950                 955                 960 


Val Val Leu Gln Ser Leu Asn Pro Trp Arg Ala Asp Val Tyr Phe Asn 
                965                 970                 975     


Pro Glu Thr Leu Lys Tyr Glu Leu Leu Gly Leu Lys Tyr Ser Asp Leu 
            980                 985                 990         


Ser Phe Glu Lys Gly Thr Gly Lys  Tyr His Ile Ser Gln  Glu Lys Tyr 
        995                 1000                 1005             


Asp Val  Ile Lys Glu Lys Glu  Gly Ile Gly Lys Lys  Ser Glu Phe 
    1010                 1015                 1020             


Lys Phe  Thr Leu Tyr Arg Asn  Asp Leu Ile Leu Ile  Lys Asp Thr 
    1025                 1030                 1035             


Ala Ser  Gly Glu Gln Glu Ile  Tyr Arg Phe Leu Ser  Arg Thr Met 
    1040                 1045                 1050             


Pro Asn  Val Lys His Tyr Ala  Glu Leu Lys Pro Tyr  Asp Lys Glu 
    1055                 1060                 1065             


Lys Phe  Asp Asn Val Gln Glu  Leu Val Glu Ala Leu  Gly Glu Ala 
    1070                 1075                 1080             


Asp Lys  Val Gly Arg Cys Ile  Lys Gly Leu Asn Lys  Ser Asn Leu 
    1085                 1090                 1095             


Ser Ile  Tyr Lys Val Arg Thr  Asp Val Leu Gly Asn  Lys Tyr Phe 
    1100                 1105                 1110             


Val Lys  Lys Glu Gly Asp Lys  Pro Lys Leu Asp Phe  Lys Asn Asn 
    1115                 1120                 1125             


Lys Lys  
    1130 


<210> 461
<211> 1136
<212> PRT
<213> Streptococcus gordonii

<400> 461
Met Asn Gly Leu Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Glu Lys Asp Thr Gly Lys Ile Ile His Ala Ser Ser 
            20                  25                  30          


Arg Leu Phe Pro Ala Ala Thr Ala Asp Asn Asn Val Glu Arg Arg Ser 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Asn Arg Arg Lys Lys His Arg Ser Val 
    50                  55                  60                  


Arg Leu Gln Asp Leu Phe Glu Gly Tyr Gly Leu Leu Thr Asp Phe Ser 
65                  70                  75                  80  


Lys Val Ser Met Asn Leu Asn Pro Tyr Gln Leu Arg Val Gln Gly Met 
                85                  90                  95      


Glu Asn Gln Leu Thr Asn Glu Glu Leu Phe Val Ala Leu Lys Asn Ile 
            100                 105                 110         


Val Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly 
        115                 120                 125             


Gly Thr Val Ser Ser Asp Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 
    130                 135                 140                 


Leu Leu Ala Glu Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe Glu 
145                 150                 155                 160 


Lys Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Glu Asn Gly Glu 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Arg Lys Glu 
            180                 185                 190         


Ala Glu Arg Ile Leu Arg Lys Gln Gln Glu Phe Asn Ser Lys Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Glu Asp Tyr Leu Ile Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Thr Glu Glu Tyr Arg Ala Ser Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Lys Leu Ile 
    290                 295                 300                 


Ile Glu Tyr Ala Lys Ser Ala Lys Thr Leu Gly Ala Ser Thr Leu Leu 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Met Ile Asp Ala Ser Val Asp Gln Ile Arg Gly 
                325                 330                 335     


Tyr Arg Val Asp Val Asn Asn Lys Pro Glu Met His Thr Phe Glu Val 
            340                 345                 350         


Tyr Arg Lys Met Gln Ser Leu Glu Thr Ile Lys Val Glu Glu Leu Pro 
        355                 360                 365             


Arg Lys Val Leu Asp Glu Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Glu Ala Ile Asn Ser Lys Leu Lys Asp Ile Phe 
385                 390                 395                 400 


Asn Arg Asp Gln Val Leu Glu Leu Val Gln Phe Arg Lys Asn Asn Ser 
                405                 410                 415     


Ser Leu Phe Ser Lys Gly Trp His Asn Phe Ser Ile Lys Leu Met Met 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Gly Lys Gln Arg Ser Lys Glu Thr Ser Lys Arg Thr 
    450                 455                 460                 


Lys Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn Pro Val 
465                 470                 475                 480 


Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Glu Ala Thr 
                485                 490                 495     


Lys Lys Tyr Gly Ile Phe Asp Asn Ile Val Ile Glu Met Ala Arg Glu 
            500                 505                 510         


Asn Asn Glu Glu Asp Ala Lys Lys Asp Tyr Ile Lys Arg Gln Lys Ala 
        515                 520                 525             


Asn Gln Asp Glu Lys Asn Ala Ala Met Glu Lys Ala Ala Phe Gln Tyr 
    530                 535                 540                 


Asn Gly Lys Lys Glu Leu Pro Asp Asn Ile Phe His Gly His Lys Glu 
545                 550                 555                 560 


Leu Thr Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys Cys Leu 
                565                 570                 575     


Tyr Thr Gly Lys Asn Ile Pro Ile Ser Asp Leu Ile His Asn Gln Tyr 
            580                 585                 590         


Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp Asp 
        595                 600                 605             


Ser Leu Ser Asn Lys Val Leu Val Leu Ala Thr Ala Asn Gln Glu Lys 
    610                 615                 620                 


Gly Gln Arg Thr Pro Phe Gln Ala Leu Asp Ser Met Asp Asp Ala Trp 
625                 630                 635                 640 


Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys Asp Ser Lys Leu Leu Ser 
                645                 650                 655     


Asn Lys Lys Lys Asp Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys Ile 
            660                 665                 670         


Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg Tyr 
        675                 680                 685             


Ser Ser Arg Val Val Leu Asn Ala Leu Gln Asp Phe Tyr Lys Ser His 
    690                 695                 700                 


Gln Leu Asp Thr Thr Ile Ser Val Val Arg Gly Gln Phe Thr Ser Gln 
705                 710                 715                 720 


Leu Arg Arg Lys Trp Gly Ile Glu Lys Ser Arg Glu Thr Tyr His His 
                725                 730                 735     


His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg Leu 
            740                 745                 750         


Trp Lys Lys His Ser Asn Pro Leu Ile Ala Tyr Lys Glu Gly Gln Phe 
        755                 760                 765             


Val Asp Ser Glu Thr Gly Glu Ile Val Ser Leu Ser Asp Glu Glu Tyr 
    770                 775                 780                 


Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp Thr Leu 
785                 790                 795                 800 


Arg Ser Lys Lys Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Tyr Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Lys Ala Lys Leu Asp Lys Glu Lys Lys Glu Tyr Thr Tyr Thr Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ala Leu Gly Thr Lys Thr Pro Ser Lys Thr 
    850                 855                 860                 


Gly Phe Tyr Lys Phe Leu Asp Leu Tyr Lys Thr Asp Lys Ser Gln Phe 
865                 870                 875                 880 


Leu Met Tyr Gln Lys Asp Arg Lys Thr Trp Asp Glu Val Ile Glu Lys 
                885                 890                 895     


Ile Ile Glu Gln Tyr Arg Pro Phe Lys Glu Tyr Asp Lys Asn Gly Lys 
            900                 905                 910         


Glu Val Asp Phe Asn Pro Phe Glu Lys Tyr Arg Ile Gly Asn Gly Pro 
        915                 920                 925             


Ile Arg Lys Tyr Ser Lys Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu 
    930                 935                 940                 


Lys Tyr Tyr Asp Ile Leu Leu Gly Lys His Lys Asn Ile Thr Pro Asp 
945                 950                 955                 960 


Gly Ser Arg Asn Thr Val Ala Leu Leu Ser Leu Asn Pro Trp Arg Thr 
                965                 970                 975     


Asp Val Tyr Tyr Asn Ser Glu Thr Lys Lys Tyr Glu Phe Leu Gly Leu 
            980                 985                 990         


Lys Tyr Ala Asp Leu Cys Phe Glu  Glu Gly Gly Ala Tyr  Gly Ile Ser 
        995                 1000                 1005             


Glu Val  Lys Tyr Lys Lys Ile  Arg Glu Lys Glu Gly  Ile Gly Lys 
    1010                 1015                 1020             


Asn Ser  Glu Phe Lys Phe Thr  Leu Tyr Lys Asn Asp  Leu Ile Leu 
    1025                 1030                 1035             


Ile Lys  Asp Thr Glu Thr Asn  Cys Gln Gln Phe Phe  Arg Phe Trp 
    1040                 1045                 1050             


Ser Arg  Thr Gly Lys Asp Asn  Pro Lys Ser Phe Glu  Lys His Lys 
    1055                 1060                 1065             


Ile Glu  Leu Lys Pro Tyr Glu  Lys Ala Lys Phe Glu  Lys Gly Glu 
    1070                 1075                 1080             


Glu Leu  Lys Val Leu Gly Lys  Val Pro Pro Ser Ser  Asn Gln Phe 
    1085                 1090                 1095             


Gln Lys  Asn Met Gln Ile Glu  Asn Leu Ser Ile Tyr  Lys Val Lys 
    1100                 1105                 1110             


Thr Asp  Ile Leu Gly Asn Lys  His Phe Ile Lys Lys  Glu Gly Asp 
    1115                 1120                 1125             


Glu Pro  Lys Leu Lys Phe Lys  Lys 
    1130                 1135     


<210> 462
<211> 1129
<212> PRT
<213> Streptococcus infantarius


<220>
<223> Streptococcus infantarius subsp. infantarius ATCC BAA-102

<400> 462
Met Ser Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Val Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Asp Ser Lys Thr Gly Asn Val Ile His Ala Asn 
            20                  25                  30          


Ser Arg Leu Phe Ser Ala Ala Asn Ala Glu Asn Asn Ala Glu Arg Arg 
        35                  40                  45              


Gly Phe Arg Gly Ala Arg Arg Leu Thr Arg Arg Lys Lys His Arg Val 
    50                  55                  60                  


Lys Arg Val Arg Asp Leu Phe Glu Lys Tyr Asp Ile Ser Thr Asp Phe 
65                  70                  75                  80  


Arg Asn Leu Asn Leu Asn Pro Tyr Glu Leu Arg Val Lys Gly Leu Thr 
                85                  90                  95      


Glu Gln Leu Thr Asn Glu Glu Leu Phe Ala Ala Leu Arg Thr Ile Ala 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Thr 
        115                 120                 125             


Gly Ser Ser Asp Tyr Ala Lys Ser Ile Asp Glu Asn Arg Arg Leu Leu 
    130                 135                 140                 


Lys Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Leu Glu Lys Tyr 
145                 150                 155                 160 


Gly Gln Leu Arg Gly Asn Phe Thr Val Tyr Asp Glu Asn Gly Glu Ala 
                165                 170                 175     


His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Lys Asn Glu Ala 
            180                 185                 190         


Arg Lys Ile Leu Glu Thr Gln Ser Asn Tyr Asn Lys Gln Ile Thr Asp 
        195                 200                 205             


Glu Phe Ile Glu Asp Tyr Ile Glu Ile Leu Thr Gln Lys Arg Lys Tyr 
    210                 215                 220                 


Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg Phe 
225                 230                 235                 240 


Arg Thr Asp Gly Thr Thr Leu Glu Asn Ile Phe Gly Ile Leu Ile Gly 
                245                 250                 255     


Lys Cys Ser Phe Tyr Pro Glu Glu Tyr Arg Ala Ser Lys Ala Ser Tyr 
            260                 265                 270         


Thr Ala Gln Glu Phe Asn Phe Leu Asn Asp Leu Asn Asn Leu Lys Val 
        275                 280                 285             


Pro Thr Glu Thr Gly Lys Leu Ser Thr Glu Gln Lys Glu Tyr Leu Val 
    290                 295                 300                 


Asp Phe Ala Lys Lys Ser Lys Ala Leu Gly Ala Ser Lys Leu Leu Lys 
305                 310                 315                 320 


Glu Ile Ala Lys Ile Val Asp Cys Ser Val Asp Asp Ile Lys Gly Tyr 
                325                 330                 335     


Arg Val Asp Asn Lys Asp Lys Pro Asp Leu His Thr Phe Glu Pro Tyr 
            340                 345                 350         


Arg Lys Leu Lys Phe Asn Leu Ser Ser Ile Asp Ile Asp Glu Leu Ser 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Asp Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Asp Ala Ile Lys Arg Asn Leu Pro Ser Gln Phe 
385                 390                 395                 400 


Thr Glu Glu Gln Ile Ser Glu Ile Val Gln Ile Arg Lys Asn Gln Ser 
                405                 410                 415     


Ser Ala Phe Asn Lys Gly Trp His Ser Phe Ser Ala Lys Leu Met Asn 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Val Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Glu Lys Phe Lys Val Asn Lys Lys Ser Ser Lys Asn 
    450                 455                 460                 


Thr Lys Thr Ile Asp Glu Lys Glu Ile Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Thr Ile Lys Ile Ile Asn Ala Ala 
                485                 490                 495     


Val Lys Lys Tyr Gly Asp Phe Asp Lys Ile Val Ile Glu Met Pro Arg 
            500                 505                 510         


Asp Lys Asn Ala Glu Asp Glu Lys Lys Phe Ile Asp Lys Lys Gln Lys 
        515                 520                 525             


Glu Asn Lys Lys Glu Lys Asp Asp Ser Leu Lys Arg Ala Ala Phe Leu 
    530                 535                 540                 


Tyr Asn Gly Thr Asp Asn Leu Pro Asp Gly Val Phe His Gly Asn Lys 
545                 550                 555                 560 


Glu Leu Lys Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Ser Gly Lys Leu Ile Ser Ile His Asp Leu Val His Asn Ser 
            580                 585                 590         


Asn Lys Phe Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Trp Thr Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Lys Thr Pro Tyr Gln Val Ile Asp Ser Met Asp Thr Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Met Lys Asp Tyr Val Leu Lys Gln Lys Gly Leu 
                645                 650                 655     


Gly Lys Lys Lys Cys Glu Tyr Leu Leu Thr Thr Glu Asn Ile Asp Lys 
            660                 665                 670         


Ile Glu Val Lys Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ser Leu Gln Thr Ala Leu Lys Glu 
    690                 695                 700                 


Leu Gly Lys Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg Lys Trp Asn Ile Asp Lys Ser Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Lys 
            740                 745                 750         


Leu Trp Gln Lys Gln Glu Asn Pro Met Phe Glu Ser Tyr Gly Glu Asn 
        755                 760                 765             


Gln Val Val Asn Lys Glu Thr Gly Glu Ile Leu Ser Ile Ser Asp Asp 
    770                 775                 780                 


Lys Tyr Lys Glu Leu Val Phe Gln Pro Pro Tyr Gln Gly Phe Val Asn 
785                 790                 795                 800 


Thr Ile Ser Ser Lys Gly Phe Glu Asp Glu Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Phe Asn Arg Lys Val Ser Asp Ala Thr Ile Tyr Ser 
            820                 825                 830         


Thr Arg Lys Ala Lys Leu Gly Lys Asp Lys Lys Asp Glu Thr Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gln Asp Gly Phe Asp Thr Phe 
    850                 855                 860                 


Ile Lys Arg Tyr Lys Lys Asp Lys Thr Gln Phe Leu Met Tyr Gln Lys 
865                 870                 875                 880 


Asp Pro Leu Thr Trp Glu Asn Val Ile Glu Val Ile Leu Arg Asp Tyr 
                885                 890                 895     


Pro Ser Glu Lys Leu Ser Glu Asp Gly Lys Lys Thr Val Lys Cys Asn 
            900                 905                 910         


Pro Phe Glu Glu Tyr Arg Arg Glu Asn Gly Leu Ile Cys Lys Tyr Ser 
        915                 920                 925             


Lys Lys Gly Asn Gly Thr Pro Ile Lys Ser Leu Lys Tyr Tyr Asp Lys 
    930                 935                 940                 


Lys Leu Gly Asn Cys Ile Asp Ile Thr Pro Glu Lys Ser Lys Asn Arg 
945                 950                 955                 960 


Val Val Leu Arg Gln Ile Ser Pro Trp Arg Ala Asp Ile Tyr Phe Asn 
                965                 970                 975     


Leu Glu Thr Leu Lys Tyr Glu Leu Met Gly Leu Lys Tyr Ser Asp Leu 
            980                 985                 990         


Ser Phe Glu Lys Gly Thr Gly Lys  Tyr His Ile Ser Gln  Glu Lys Tyr 
        995                 1000                 1005             


Asp Ala  Ile Arg Glu Lys Glu  Gly Ile Gly Lys Lys  Ser Glu Phe 
    1010                 1015                 1020             


Lys Phe  Thr Leu Tyr Arg Asn  Asp Leu Ile Leu Ile  Lys Asp Thr 
    1025                 1030                 1035             


Leu Asn  Asn Cys Glu Arg Met  Leu Arg Phe Gly Ser  Lys Asn Asp 
    1040                 1045                 1050             


Thr Ser  Lys His Tyr Val Glu  Leu Lys Pro Leu Glu  Lys Gly Thr 
    1055                 1060                 1065             


Phe Asp  Ser Glu Glu Glu Ile  Leu Pro Val Leu Gly  Lys Val Ala 
    1070                 1075                 1080             


Lys Ser  Gly Gln Phe Ile Lys  Gly Leu Asn Lys Pro  Asn Ile Ser 
    1085                 1090                 1095             


Ile Tyr  Lys Val Arg Thr Asp  Val Leu Gly Asn Lys  Phe Phe Ile 
    1100                 1105                 1110             


Lys Lys  Glu Gly Asp Lys Pro  Lys Leu Asp Phe Lys  Asn Asn Asn 
    1115                 1120                 1125             


Lys 
    


<210> 463
<211> 1375
<212> PRT
<213> Streptococcus infantarius

<400> 463
Met Glu Lys Ser Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Val Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Lys Glu Met Thr Lys Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Glu Ser Phe Leu Thr Asp Asp Asp Lys Thr 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Gln Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Asn Val Phe Val Glu Thr Tyr 
            180                 185                 190         


Asp Lys Ile Val Asp Glu Ser His Leu Ser Glu Ile Glu Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Lys Gln Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Val Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ile Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Val Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ile Asn Lys Leu Lys Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Lys Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Thr Ile Leu Thr Lys Ile Asp 
    370                 375                 380                 


Asp Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Asp Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ser Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Ala Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asp Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Asn Tyr His Ser Asp Glu Pro Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Val Val Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


His Val Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Glu Ser Phe Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Ala Lys Leu Leu Ser Tyr Leu Asn Asn Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Asn Asp Leu Ile Gly Leu Asp Lys Asp Ser Lys Ser Phe Asn Ala Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ser Phe Leu 
        595                 600                 605             


Asp Asp Lys Thr Asn Gly Gln Ile Ile Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Asp Met Ile His Glu Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Phe Phe Thr Ser Gln Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Phe Leu Ile Asp Asp Gly 
        675                 680                 685             


His Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Glu Ser Leu Ser 
    690                 695                 700                 


Phe Lys Thr Ile Ile Gln Glu Ala Gln Val Val Gly Asp Val Asp Asp 
705                 710                 715                 720 


Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Asp Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gly Tyr Gly Arg Asn Lys Ser Asn Gln Arg Leu Lys Arg Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Glu Phe Gly Ser Asp Ile Leu Ser Lys Lys Lys 
785                 790                 795                 800 


Pro Ser Tyr Val Asp Ser Lys Val Glu Asn Ser His Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Glu Glu Leu Asp Ile Asp Arg Leu Ser Asp Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile 
865                 870                 875                 880 


Glu Ile Val Arg Asn Arg Arg Ser Tyr Trp Tyr Lys Leu Tyr Lys Ser 
                885                 890                 895     


Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala 
    930                 935                 940                 


Arg Phe Asn Thr Lys Arg Asp Glu Asn Asp Lys Val Ile Arg Asp Val 
945                 950                 955                 960 


Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys Glu 
                965                 970                 975     


Phe Lys Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Val  Gly Thr Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Thr Pro Glu Phe  Val Tyr Gly Glu Tyr  Lys Lys Tyr 
    1010                 1015                 1020             


Asp Val  Arg Lys Leu Ile Ala  Lys Ser Ser Asp Asp  Tyr Ser Glu 
    1025                 1030                 1035             


Met Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe Tyr Ser  Asn Leu Met 
    1040                 1045                 1050             


Asn Phe  Phe Lys Thr Glu Val  Lys Tyr Ala Asp Gly  Arg Val Phe 
    1055                 1060                 1065             


Glu Arg  Pro Asp Ile Glu Thr  Asn Ala Asp Gly Glu  Val Val Trp 
    1070                 1075                 1080             


Asn Lys  Gln Lys Asp Phe Asp  Ile Val Arg Lys Val  Leu Ser Tyr 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Ala Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Ser Lys Gly Asp Ser  Asp Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Thr Lys Lys  Val Tyr Trp Asn Thr  Lys Lys Tyr 
    1130                 1135                 1140             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1145                 1150                 1155             


Ala Asp  Ile Glu Lys Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys 
    1160                 1165                 1170             


Glu Leu  Val Gly Ile Ser Ile  Met Glu Arg Ser Phe  Phe Glu Glu 
    1175                 1180                 1185             


Asn Pro  Val Ser Phe Leu Glu  Lys Lys Gly Tyr His  Asn Val Gln 
    1190                 1195                 1200             


Glu Asp  Lys Leu Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Phe 
    1205                 1210                 1215             


Glu Gly  Gly Arg Arg Arg Leu  Leu Ala Ser Ala Thr  Glu Leu Gln 
    1220                 1225                 1230             


Lys Gly  Asn Glu Val Met Leu  Pro Ala His Leu Val  Glu Leu Leu 
    1235                 1240                 1245             


Tyr His  Ala His Arg Ile Asp  Ser Phe Asn Ser Thr  Glu His Leu 
    1250                 1255                 1260             


Lys Tyr  Val Ser Glu His Lys  Lys Glu Phe Glu Lys  Val Leu Ser 
    1265                 1270                 1275             


Cys Val  Glu Asn Phe Ser Asn  Leu Tyr Val Asp Val  Glu Lys Asn 
    1280                 1285                 1290             


Leu Ser  Lys Val Arg Ala Ala  Ala Glu Ser Met Thr  Asn Phe Ser 
    1295                 1300                 1305             


Leu Glu  Glu Ile Ser Ala Ser  Phe Ile Asn Leu Leu  Thr Leu Thr 
    1310                 1315                 1320             


Ala Leu  Gly Ala Pro Ala Asp  Phe Asn Phe Leu Gly  Glu Lys Ile 
    1325                 1330                 1335             


Pro Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Cys Leu  Ser Ala Thr 
    1340                 1345                 1350             


Leu Ile  His Gln Ser Val Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1355                 1360                 1365             


Leu Ser  Lys Leu Gly Glu Glu  
    1370                 1375 


<210> 464
<211> 1368
<212> PRT
<213> Streptococcus iniae


<220>
<223> Streptococcus iniae 9117

<400> 464
Met Arg Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Arg Ile Gln Gly Thr Thr Asp Arg Thr Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Asn Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Thr Arg Arg Arg Tyr Thr Arg Arg Lys Tyr Arg Ile Lys 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ser Ser Glu Met Asn Glu Leu Asp Ile Ala 
                85                  90                  95      


Phe Phe Pro Arg Leu Ser Glu Ser Phe Leu Val Ser Asp Asp Lys Glu 
            100                 105                 110         


Phe Glu Asn His Pro Ile Phe Gly Asn Leu Lys Asp Glu Ile Thr Tyr 
        115                 120                 125             


His Asn Asp Tyr Pro Thr Ile Tyr His Leu Arg Gln Thr Leu Ala Asp 
    130                 135                 140                 


Ser Asp Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asn Leu Asp Ser 
                165                 170                 175     


Glu Asn Thr Asp Val His Val Leu Phe Leu Asn Leu Val Asn Ile Tyr 
            180                 185                 190         


Asn Asn Leu Phe Glu Glu Asp Ile Val Glu Thr Ala Ser Ile Asp Ala 
        195                 200                 205             


Glu Lys Ile Leu Thr Ser Lys Thr Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Glu Ile Pro Asn Gln Lys Arg Asn Met Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Val Ser Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Glu Leu Leu Glu Asp Ala Lys Leu Gln Ile Ser Lys Asp Ser Tyr Glu 
            260                 265                 270         


Glu Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ile Ala Ala Lys Lys Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Ile Thr Val Lys Gly Ala Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Gln Arg Tyr Glu Glu His Gln Gln Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Asn Leu Val Lys Lys Gln Ile Pro Glu Lys Tyr Lys Glu Ile Phe Asp 
            340                 345                 350         


Asn Lys Glu Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Tyr Ile Lys Pro Ile Leu Leu Lys Leu Asp 
    370                 375                 380                 


Gly Thr Glu Lys Leu Ile Ser Lys Leu Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Asn Glu Leu Lys Ala Ile Ile Arg Arg Gln Glu Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Lys Lys Ile Glu Lys Leu Phe Thr Phe Lys Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Asn Gly Gln Ser Ser Phe Ala Trp 
    450                 455                 460                 


Leu Lys Arg Gln Ser Asn Glu Ser Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Gln Glu Ala Ser Ala Arg Ala Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Thr Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Met Phe Met Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Gln Thr Glu Gly Met Lys Arg Pro Val Phe Leu Ser Ser Glu Asp 
    530                 535                 540                 


Lys Glu Glu Ile Val Asn Leu Leu Phe Lys Lys Glu Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Glu Tyr Phe Ser Lys Met Lys Cys Phe His 
                565                 570                 575     


Thr Val Thr Ile Leu Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Phe Lys Asp Lys Ala Phe Leu Asp 
        595                 600                 605             


Asp Glu Ala Asn Gln Asp Ile Leu Glu Glu Ile Val Trp Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Gln Ala Met Ile Glu Arg Arg Leu Val Lys Tyr Ala 
625                 630                 635                 640 


Asp Val Phe Glu Lys Ser Val Leu Lys Lys Leu Lys Lys Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Gln Lys Leu Ile Asn Gly Ile Lys Asp 
            660                 665                 670         


Lys Gln Thr Gly Lys Thr Ile Leu Gly Phe Leu Lys Asp Asp Gly Val 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Ser Ser Leu Asp Phe 
    690                 695                 700                 


Ala Lys Ile Ile Lys Asn Glu Gln Glu Lys Thr Ile Lys Asn Glu Ser 
705                 710                 715                 720 


Leu Glu Glu Thr Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Ile Val Lys Ile Met 
            740                 745                 750         


Gly Gln Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Ser Thr Met Gln Gly Ile Lys Asn Ser Arg Gln Arg Leu Arg Lys Leu 
    770                 775                 780                 


Glu Glu Val His Lys Asn Thr Gly Ser Lys Ile Leu Lys Glu Tyr Asn 
785                 790                 795                 800 


Val Ser Asn Thr Gln Leu Gln Ser Asp Arg Leu Tyr Leu Tyr Leu Leu 
                805                 810                 815     


Gln Asp Gly Lys Asp Met Tyr Thr Gly Lys Glu Leu Asp Tyr Asp Asn 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Thr Val Leu Thr Thr Gln Ala Ser Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Asn Ile Glu Thr Val Asn Lys Met Lys 
865                 870                 875                 880 


Ser Phe Trp Tyr Lys Gln Leu Lys Ser Gly Ala Ile Ser Gln Arg Lys 
                885                 890                 895     


Phe Asp His Leu Thr Lys Ala Glu Arg Gly Ala Leu Ser Asp Phe Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Phe Asn Ser Asn Leu Thr 
    930                 935                 940                 


Glu Asp Ser Lys Ser Asn Arg Asn Val Lys Ile Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Met Val Ser Asp Phe Arg Lys Asp Phe Gly Phe Tyr Lys Leu Arg 
                965                 970                 975     


Glu Val Asn Asp Tyr His His Ala Gln Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Leu Lys Lys  Tyr Pro Lys Leu Glu  Ala Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys His  Tyr Asp Leu Ala Lys  Leu Met Ile 
    1010                 1015                 1020             


Gln Pro  Asp Ser Ser Leu Gly  Lys Ala Thr Thr Arg  Met Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Lys Glu Ile  Lys Leu Ala 
    1040                 1045                 1050             


Asp Asp  Thr Ile Phe Thr Arg  Pro Gln Ile Glu Val  Asn Thr Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Val Lys Asp Met  Gln Thr Ile 
    1070                 1075                 1080             


Arg Lys  Val Met Ser Tyr Pro  Gln Val Asn Ile Val  Met Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Trp Pro Lys 
    1100                 1105                 1110             


Gly Asp  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Ser  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Ile Ile Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Ile Ala  Lys Gly Lys Thr Gln  Lys Leu Lys 
    1145                 1150                 1155             


Thr Ile  Lys Glu Leu Val Gly  Ile Lys Ile Met Glu  Gln Asp Glu 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Ile Ala  Phe Leu Glu Lys Lys  Gly Tyr Gln 
    1175                 1180                 1185             


Asp Ile  Gln Thr Ser Ser Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Leu Leu Ala  Ser Ala Lys 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Asn  Lys Tyr Val 
    1220                 1225                 1230             


Lys Phe  Leu Tyr Leu Ala Ser  His Tyr Thr Lys Phe  Thr Gly Lys 
    1235                 1240                 1245             


Glu Glu  Asp Arg Glu Lys Lys  Arg Ser Tyr Val Glu  Ser His Leu 
    1250                 1255                 1260             


Tyr Tyr  Phe Asp Glu Ile Met  Gln Ile Ile Val Glu  Tyr Ser Asn 
    1265                 1270                 1275             


Arg Tyr  Ile Leu Ala Asp Ser  Asn Leu Ile Lys Ile  Gln Asn Leu 
    1280                 1285                 1290             


Tyr Lys  Glu Lys Asp Asn Phe  Ser Ile Glu Glu Gln  Ala Ile Asn 
    1295                 1300                 1305             


Met Leu  Asn Leu Phe Thr Phe  Thr Asp Leu Gly Ala  Pro Ser Ala 
    1310                 1315                 1320             


Phe Lys  Phe Phe Asn Gly Asp  Ile Asp Arg Lys Arg  Tyr Ser Ser 
    1325                 1330                 1335             


Thr Asn  Glu Ile Ile Asn Ser  Thr Leu Ile Tyr Gln  Ser Pro Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Lys Leu  Gly Gly Lys 
    1355                 1360                 1365             


<210> 465
<211> 1338
<212> PRT
<213> Streptococcus macacae


<220>
<223> Streptococcus macacae NCTC 11558

<400> 465
Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Gly Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Lys Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ala Lys Ala Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Asn Glu Ser Phe Leu Thr Asn Asp Asp Lys Glu 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Glu Ala His 
        115                 120                 125             


His His Lys Phe Pro Thr Ile Phe His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ser Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asn Val Gln Thr Leu Phe Asp Asp Phe Val Glu Val Tyr 
            180                 185                 190         


Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Ile Ser Val Ser Ser 
        195                 200                 205             


Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
    210                 215                 220                 


Lys Tyr Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn Leu Ile 
225                 230                 235                 240 


Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe Lys Leu 
                245                 250                 255     


Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu Glu Asp 
            260                 265                 270         


Leu Gly Glu Leu Leu Gly Lys Ile Gly Asp Asn Tyr Ala Asp Leu Phe 
        275                 280                 285             


Ile Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly Ile Leu 
    290                 295                 300                 


Thr Ile Asp Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
305                 310                 315                 320 


Lys Arg Tyr Glu Glu His Gln Glu Asp Leu Ala Gln Leu Lys Lys Phe 
                325                 330                 335     


Ile Arg Gln Asn Leu Pro Asp Gln Tyr Ser Glu Val Phe Ser Asp Lys 
            340                 345                 350         


Thr Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn Gln Glu 
        355                 360                 365             


Ala Phe Tyr Lys Tyr Ile Lys Asn Met Leu Ser Lys Thr Glu Gly Ala 
    370                 375                 380                 


Asp Tyr Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg Lys Gln 
385                 390                 395                 400 


Arg Thr Phe Asp Asn Gly Ser Val Pro His Gln Ile His Leu Gln Glu 
                405                 410                 415     


Met His Ala Ile Leu Arg Arg Gln Gly Glu Tyr Tyr Pro Phe Leu Lys 
            420                 425                 430         


Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
        435                 440                 445             


Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp Ala Glu 
    450                 455                 460                 


Tyr Lys Ala Asp Lys Lys Val Thr Pro Trp Asn Phe Asp Asp Ile Leu 
465                 470                 475                 480 


Asp Lys Glu Lys Ser Ala Glu Glu Phe Ile Thr Arg Met Thr Leu Asn 
                485                 490                 495     


Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser Leu Val 
            500                 505                 510         


Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
        515                 520                 525             


Asn Glu Gln Gly Lys Ala Ile Phe Phe Asp Ala Asn Met Lys Gln Glu 
    530                 535                 540                 


Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys Asp Lys 
545                 550                 555                 560 


Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile Val Asn 
                565                 570                 575     


Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ser Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu Asp Asp 
        595                 600                 605             


Lys Val Asn Glu Lys Ile Ile Glu Asp Ile Ile Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr Ser Asp 
625                 630                 635                 640 


Ile Phe Thr Thr Gln Gln Leu Lys Lys Leu Glu Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Asn Lys Thr Ile Leu Gly Tyr Leu Ile Asp Asp Gly Tyr Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Pro Phe Lys 
    690                 695                 700                 


Glu Glu Ile Ala Arg Ala Gln Val Ile Gly Glu Thr Asp Asp Leu Asn 
705                 710                 715                 720 


Gln Leu Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His 
            740                 745                 750         


Asn Pro Ala Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Arg Arg Ser Ser Gln Gln Arg Tyr Lys Arg Leu Glu Glu 
    770                 775                 780                 


Ala Ile Lys Asn Leu Asp His Asp Leu Asn His Lys Ile Leu Lys Glu 
785                 790                 795                 800 


His Pro Thr Asp Asn Gln Ala Leu Gln Asn Asp Arg Leu Phe Leu Tyr 
                805                 810                 815     


Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Glu Asp Pro Leu Asp Ile 
            820                 825                 830         


Asn Arg Leu Ser Asp Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe 
        835                 840                 845             


Ile Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Val Ser Ser Ala Lys 
    850                 855                 860                 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Asp Val Val Asn Arg 
865                 870                 875                 880 


Met Arg Pro Phe Trp Asn Lys Leu Leu Ser Cys Gly Leu Ile Ser Gln 
                885                 890                 895     


Arg Lys Tyr Ser Asn Leu Thr Lys Lys Glu Leu Lys Pro Asp Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Thr Lys Arg Asp Glu 
    930                 935                 940                 


Asn Lys Lys Val Ile Arg Asp Val Lys Ile Ile Thr Leu Lys Ser Asn 
945                 950                 955                 960 


Leu Val Ser Gln Phe Arg Lys Asp Phe Lys Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Ile 
            980                 985                 990         


Gly Lys Ala Leu Leu Asp Val Tyr  Pro Gln Leu Glu Pro  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Glu Tyr Pro His Phe  His Gly Tyr Lys Glu  Asn Lys Ala 
    1010                 1015                 1020             


Thr Ala  Lys Lys Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1025                 1030                 1035             


Lys Asp  Asp Ile Arg Thr Asp  Glu Asn Gly Glu Ile  Val Trp Lys 
    1040                 1045                 1050             


Lys Asp  Glu His Ile Ser Asn  Ile Lys Arg Val Leu  Ser Tyr Pro 
    1055                 1060                 1065             


Gln Val  Asn Ile Val Lys Lys  Val Glu Ile Gln Thr  Val Gly Gln 
    1070                 1075                 1080             


Asn Gly  Gly Leu Phe Asp Asp  Asn Pro Lys Ser Pro  Leu Glu Val 
    1085                 1090                 1095             


Thr Pro  Ser Lys Leu Val Pro  Leu Lys Lys Glu Leu  Asn Pro Lys 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Tyr Gln Lys  Pro Thr Thr Ala Tyr  Pro Val Leu 
    1115                 1120                 1125             


Leu Ile  Thr Asp Thr Lys Gln  Leu Ile Pro Ile Ser  Val Met Asn 
    1130                 1135                 1140             


Lys Lys  Gln Phe Glu Gln Asn  Pro Val Lys Phe Leu  Arg Asp Arg 
    1145                 1150                 1155             


Gly Tyr  Gln Gln Val Gly Lys  Asn Asp Phe Ile Lys  Leu Pro Lys 
    1160                 1165                 1170             


Tyr Thr  Leu Val Asp Ile Gly  Asp Gly Ile Lys Arg  Leu Trp Ala 
    1175                 1180                 1185             


Ser Ser  Lys Glu Ile His Lys  Gly Asn Gln Leu Val  Val Ser Lys 
    1190                 1195                 1200             


Lys Ser  Gln Ile Leu Leu Tyr  His Ala His His Leu  Asp Ser Asp 
    1205                 1210                 1215             


Leu Ser  Asn Asp Tyr Leu Gln  Asn His Asn Gln Gln  Phe Asp Val 
    1220                 1225                 1230             


Leu Phe  Asn Glu Ile Ile Ser  Phe Ser Lys Lys Cys  Lys Leu Gly 
    1235                 1240                 1245             


Lys Glu  His Ile Gln Lys Ile  Glu Asn Val Tyr Ser  Asn Lys Lys 
    1250                 1255                 1260             


Asn Ser  Ala Ser Ile Glu Glu  Leu Ala Glu Ser Phe  Ile Lys Leu 
    1265                 1270                 1275             


Leu Gly  Phe Thr Gln Leu Gly  Ala Thr Ser Pro Phe  Asn Phe Leu 
    1280                 1285                 1290             


Gly Val  Lys Leu Asn Gln Lys  Gln Tyr Lys Gly Lys  Lys Asp Tyr 
    1295                 1300                 1305             


Ile Leu  Pro Cys Thr Glu Gly  Thr Leu Ile Arg Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Thr Arg Val  Asp Leu Ser Lys Ile  Gly Glu Asp 
    1325                 1330                 1335             


<210> 466
<211> 1130
<212> PRT
<213> Streptococcus macedonicus

<400> 466
Met Thr Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Glu Ala Lys Thr Gly Lys Val Val His Ala Asn 
            20                  25                  30          


Ser Arg Leu Phe Ser Ala Ala Asn Ala Glu Asn Asn Ala Glu Arg Arg 
        35                  40                  45              


Gly Phe Arg Gly Ser Arg Arg Leu Asn Arg Arg Lys Lys His Arg Val 
    50                  55                  60                  


Lys Arg Val Arg Asp Leu Phe Glu Lys Tyr Gly Ile Val Thr Asp Phe 
65                  70                  75                  80  


Arg Asn Leu Asn Leu Asn Pro Tyr Glu Leu Arg Val Lys Gly Leu Thr 
                85                  90                  95      


Glu Gln Leu Thr Asn Glu Glu Leu Phe Ala Ala Leu Arg Thr Ile Ser 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Thr 
        115                 120                 125             


Gly Ser Thr Asp Tyr Ala Lys Ser Ile Asp Glu Asn Arg Arg Leu Leu 
    130                 135                 140                 


Lys Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Leu Glu Lys Tyr 
145                 150                 155                 160 


Gly Gln Leu Arg Gly Asn Phe Thr Val Tyr Asp Glu Asn Gly Glu Ala 
                165                 170                 175     


His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Glu Lys Glu Ala 
            180                 185                 190         


Arg Lys Ile Leu Glu Thr Gln Ala Asp Tyr Asn Lys Lys Ile Thr Ala 
        195                 200                 205             


Glu Phe Ile Asp Asp Tyr Val Glu Ile Leu Thr Gln Lys Arg Lys Tyr 
    210                 215                 220                 


Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg Phe 
225                 230                 235                 240 


Arg Thr Asp Gly Thr Thr Leu Glu Asn Ile Phe Gly Ile Leu Ile Gly 
                245                 250                 255     


Lys Cys Asn Phe Tyr Pro Asp Glu Tyr Arg Ala Ser Lys Ala Ser Tyr 
            260                 265                 270         


Thr Ala Gln Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Lys Val 
        275                 280                 285             


Pro Thr Glu Thr Gly Lys Leu Ser Thr Glu Gln Lys Glu Ser Leu Val 
    290                 295                 300                 


Glu Phe Ala Lys Asn Thr Ala Ile Leu Gly Pro Ala Lys Leu Leu Lys 
305                 310                 315                 320 


Glu Ile Ala Lys Ile Leu Asp Cys Lys Val Asp Glu Ile Lys Gly Tyr 
                325                 330                 335     


Arg Glu Asp Asp Lys Gly Lys Pro Asp Leu His Thr Phe Glu Pro Tyr 
            340                 345                 350         


Arg Lys Leu Lys Phe Asn Leu Asp Ser Val Asn Ile Asp Tyr Leu Ser 
        355                 360                 365             


Arg Glu Val Leu Asp Lys Leu Ala Asp Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Asp Ala Ile Lys Arg Asn Leu Pro Asn Gln Phe 
385                 390                 395                 400 


Thr Glu Glu Gln Ile Ser Glu Ile Ile Asn Val Arg Lys Ser Gln Ser 
                405                 410                 415     


Thr Ala Phe Asn Lys Gly Trp His Ser Phe Ser Ala Lys Leu Met Asn 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Ala Thr Ser Asp Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Glu Lys Phe Lys Val Lys Lys Lys Ser Ser Lys Asn 
    450                 455                 460                 


Ile Lys Thr Ile Asp Glu Lys Glu Ile Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Thr Ile Lys Ile Ile Asn Ala Ala 
                485                 490                 495     


Val Lys Lys Tyr Gly Asp Phe Asp Lys Ile Val Ile Glu Met Pro Arg 
            500                 505                 510         


Asp Lys Asn Ala Asp Asp Glu Lys Lys Phe Ile Asn Lys Arg Asn Lys 
        515                 520                 525             


Glu Asn Lys Lys Glu Lys Asp Asp Ala Leu Lys Arg Ala Ala Tyr Leu 
    530                 535                 540                 


Tyr Asn Gly Thr Asp Lys Leu Pro Asp Glu Val Phe His Gly Asn Lys 
545                 550                 555                 560 


Gln Leu Glu Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Ser Gly Lys Pro Ile Pro Ile Gln Glu Leu Val His Asn Ser 
            580                 585                 590         


Asn Asn Phe Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ser Trp Thr Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Lys Thr Pro Tyr Gln Val Ile Asp Ser Met Asp Ala Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Met Lys Glu Tyr Val Leu Lys Gln Lys Gly Leu 
                645                 650                 655     


Gly Lys Lys Lys Arg Asp Tyr Leu Leu Thr Thr Glu Asn Ile Asp Lys 
            660                 665                 670         


Ile Glu Val Lys Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ser Leu Gln Ser Ala Leu Arg Glu 
    690                 695                 700                 


Leu Gly Lys Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg Lys Trp Lys Ile Asp Lys Ser Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Lys 
            740                 745                 750         


Leu Trp Glu Lys Gln Asp Asn Pro Met Phe Val Asp Tyr Gly Asn Asn 
        755                 760                 765             


Gln Val Val Asp Lys Gln Thr Gly Glu Ile Leu Ser Val Ser Asp Asn 
    770                 775                 780                 


Glu Tyr Lys Glu Leu Val Phe Gln Pro Pro Tyr Gln Gly Phe Val Asn 
785                 790                 795                 800 


Thr Ile Ser Ser Lys Gly Phe Glu Asp Glu Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Tyr Asn Arg Lys Val Ser Asp Ala Thr Ile Tyr Ser 
            820                 825                 830         


Thr Arg Lys Ala Lys Ile Gly Lys Asp Lys Lys Glu Glu Thr Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gln Asn Gly Phe Asp Thr Phe 
    850                 855                 860                 


Val Lys Lys Tyr Asn Lys Asp Lys Thr Gln Phe Leu Met Tyr Gln Lys 
865                 870                 875                 880 


Asp Pro Leu Thr Trp Glu Asn Val Ile Glu Val Ile Leu Gly Asp Tyr 
                885                 890                 895     


Pro Thr Thr Lys Lys Ser Glu Asp Gly Lys Asn Asp Val Lys Cys Asn 
            900                 905                 910         


Pro Phe Glu Glu Tyr Arg Arg Glu Asn Gly Leu Ile Cys Lys Tyr Ser 
        915                 920                 925             


Lys Lys Gly Lys Gly Thr Pro Ile Lys Ser Leu Lys Tyr Tyr Asp Lys 
    930                 935                 940                 


Lys Leu Gly Asn Cys Ile Asp Ile Thr Pro Glu Glu Ser Arg Asn Lys 
945                 950                 955                 960 


Val Ile Leu Gln Ser Ile Asn Pro Trp Arg Ala Asp Val Tyr Phe Asn 
                965                 970                 975     


Pro Glu Thr Leu Lys Tyr Glu Leu Met Gly Leu Lys Tyr Ser Asp Leu 
            980                 985                 990         


Ser Phe Glu Lys Gly Thr Gly Asn  Tyr His Ile Ser Gln  Glu Lys Tyr 
        995                 1000                 1005             


Asp Ala  Ile Lys Glu Lys Glu  Gly Ile Gly Lys Lys  Ser Glu Phe 
    1010                 1015                 1020             


Lys Phe  Thr Leu Tyr Arg Asn  Asp Leu Ile Leu Ile  Lys Asp Ile 
    1025                 1030                 1035             


Ala Ser  Gly Glu Gln Glu Ile  Tyr Arg Phe Leu Ser  Arg Thr Met 
    1040                 1045                 1050             


Pro Asn  Val Asn His Tyr Val  Glu Leu Lys Pro Tyr  Asp Lys Glu 
    1055                 1060                 1065             


Lys Phe  Asp Asn Val Gln Glu  Leu Val Glu Ala Leu  Gly Glu Ala 
    1070                 1075                 1080             


Asp Lys  Val Gly Arg Cys Ile  Lys Ser Leu Asn Lys  Pro Asn Ile 
    1085                 1090                 1095             


Ser Ile  Tyr Lys Val Arg Thr  Asp Val Leu Gly Asn  Lys Tyr Phe 
    1100                 1105                 1110             


Val Lys  Lys Glu Gly Asp Lys  Pro Lys Leu Asp Phe  Lys Asn Asn 
    1115                 1120                 1125             


Lys Lys  
    1130 


<210> 467
<211> 1134
<212> PRT
<213> Streptococcus mitis


<220>
<223> Streptococcus mitis ATCC 6249

<400> 467
Met Asn Gly Leu Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Glu Gly 
1               5                   10                  15      


Val Gly Ile Leu Glu Lys Asn Ser Gly Lys Ile Ile His Ala Asn Ser 
            20                  25                  30          


Arg Leu Phe Pro Ala Ala Thr Ala Asp Asn Asn Val Glu Arg Arg Lys 
        35                  40                  45              


Asn Arg Gln Ala Arg Arg Leu Asn Arg Arg Lys Lys His Arg Gly Val 
    50                  55                  60                  


Arg Phe Gln Asp Leu Phe Glu Asp Tyr Gly Leu Leu Thr Asp Phe Ser 
65                  70                  75                  80  


Lys Val Ser Ile Asn Leu Asn Pro Tyr Arg Leu Arg Val Asp Gly Leu 
                85                  90                  95      


Asn Gln Gln Leu Thr Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Ile 
            100                 105                 110         


Val Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly 
        115                 120                 125             


Gly Ala Val Ser Ser Asp Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 
    130                 135                 140                 


Leu Leu Ala Glu Gln Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe Glu 
145                 150                 155                 160 


Lys Tyr Gly Gln Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly Glu 
                165                 170                 175     


Lys Leu Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Lys Lys Glu 
            180                 185                 190         


Ala Glu Arg Ile Leu Arg Lys Gln Gln Glu Phe Asn Asn Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Glu Asp Tyr Leu Lys Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Glu Glu Tyr Arg Ala Ser Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Lys Val Ile 
    290                 295                 300                 


Val Glu Tyr Ala Lys Glu Ala Lys Thr Leu Gly Ala Ser Thr Leu Leu 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Met Ile Asp Ala Ser Val Asp Gln Ile Arg Gly 
                325                 330                 335     


Tyr Arg Val Asp Val Asn Asn Lys Pro Glu Met His Thr Phe Glu Val 
            340                 345                 350         


Tyr Arg Lys Met Gln Ser Leu Glu Thr Ile Ser Val Gly Glu Leu Ser 
        355                 360                 365             


Arg Asn Val Leu Asp Glu Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Met Glu Glu Ala Ile Asn Thr Lys Leu Lys Asp Ser Phe 
385                 390                 395                 400 


Ser Gln Asp Gln Val Leu Glu Leu Val Gln Phe Arg Lys Asn Asn Ser 
                405                 410                 415     


Ser Leu Phe Ser Lys Gly Trp His Asn Phe Ser Leu Lys Leu Met Met 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Gly Lys Gln Lys Ser Lys Glu Thr Ser Lys Arg Thr 
    450                 455                 460                 


Lys Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn Pro Val 
465                 470                 475                 480 


Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Glu Ala Thr 
                485                 490                 495     


Lys Lys His Gly Ile Phe Asp Asn Ile Val Ile Glu Met Ala Arg Glu 
            500                 505                 510         


Asn Asn Glu Glu Asp Ala Lys Lys Asp Tyr Ile Lys Arg Gln Lys Ala 
        515                 520                 525             


Asn Gln Asp Glu Lys Asn Ala Ala Met Glu Lys Ala Ala Phe Gln Tyr 
    530                 535                 540                 


Asn Gly Lys Lys Glu Leu Pro Asp Asn Ile Phe His Gly His Lys Glu 
545                 550                 555                 560 


Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys Cys Leu 
                565                 570                 575     


Tyr Thr Gly Lys Thr Ile Pro Ile Ser Asp Leu Ile Tyr Asn Gln Tyr 
            580                 585                 590         


Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp Asp 
        595                 600                 605             


Ser Leu Ser Asn Lys Val Leu Ala Leu Ala Thr Ala Asn Gln Glu Lys 
    610                 615                 620                 


Gly Gln Arg Thr Pro Phe Gln Ala Leu Asp Ser Met Asp Asp Ala Trp 
625                 630                 635                 640 


Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys Asp Leu Lys Ser Leu Ser 
                645                 650                 655     


Asn Lys Lys Lys Asp Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys Ile 
            660                 665                 670         


Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg Tyr 
        675                 680                 685             


Ser Ser Arg Val Val Leu Asn Ala Leu Gln Asp Phe Tyr Lys Ser His 
    690                 695                 700                 


Gln Phe Asp Thr Thr Ile Ser Val Val Arg Gly Gln Phe Thr Ser Gln 
705                 710                 715                 720 


Leu Arg Arg Lys Trp Gly Leu Glu Lys Ser Arg Glu Thr Tyr His His 
                725                 730                 735     


His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg Leu 
            740                 745                 750         


Trp Lys Lys Gln Asn Asn Pro Leu Ile Thr Tyr Lys Glu Gly Gln Phe 
        755                 760                 765             


Val Asp Ser Gln Thr Gly Glu Ile Ile Ser Leu Thr Asp Asp Glu Tyr 
    770                 775                 780                 


Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp Thr Leu 
785                 790                 795                 800 


Ser Ser Lys Thr Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Lys Ala Lys Leu Asp Lys Glu Lys Lys Glu Tyr Thr Tyr Thr Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ser Leu Gly Thr Lys Thr Pro Ser Lys Thr 
    850                 855                 860                 


Gly Phe Tyr Lys Phe Leu Asp Leu Tyr Asn Lys Asp Lys Ser Gln Phe 
865                 870                 875                 880 


Leu Met Phe Gln Lys Asp Arg Lys Thr Trp Asp Glu Val Ile Glu Lys 
                885                 890                 895     


Ile Met Glu Gln Tyr Arg Pro Phe Lys Glu Tyr Asp Lys Thr Gly Lys 
            900                 905                 910         


Leu Val Asp Phe Asn Pro Phe Glu Lys Tyr Arg Gln Glu Asn Glu Pro 
        915                 920                 925             


Ile Arg Lys Tyr Ser Lys Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu 
    930                 935                 940                 


Lys Tyr Tyr Asp Ile Leu Leu Gly Lys His Lys Asn Ile Thr Pro Glu 
945                 950                 955                 960 


Gly Ser Arg Asn Thr Val Ala Leu Leu Ser Leu Asn Pro Trp Arg Thr 
                965                 970                 975     


Asp Val Tyr Tyr Asn Met Glu Thr Lys Lys Tyr Glu Phe Leu Gly Leu 
            980                 985                 990         


Lys Tyr Ala Asp Leu Pro Phe Glu  Glu Gly Gly Ala Tyr  Gly Ile Ser 
        995                 1000                 1005             


Thr Glu  Thr Tyr Asn Glu Leu  Arg Glu Lys Glu Gly  Ile Gly Lys 
    1010                 1015                 1020             


Asn Ser  Glu Phe Lys Phe Thr  Leu Tyr Lys Asn Asp  Leu Ile Leu 
    1025                 1030                 1035             


Ile Lys  Asp Thr Glu Thr Asn  Cys Gln Gln Ile Phe  Arg Phe Trp 
    1040                 1045                 1050             


Ser Arg  Thr Gly Lys Asp Asn  Pro Lys Ser Phe Glu  Lys His Lys 
    1055                 1060                 1065             


Ile Glu  Leu Lys Pro Tyr Glu  Lys Ala Arg Phe Glu  Lys Gly Glu 
    1070                 1075                 1080             


Glu Leu  Glu Val Leu Gly Lys  Val Pro Pro Ser Ser  Asn Gln Leu 
    1085                 1090                 1095             


Gln Lys  Asn Met Gln Ile Glu  Asn Leu Ser Ile Tyr  Lys Val Lys 
    1100                 1105                 1110             


Thr Asp  Val Leu Gly Asn Lys  His Phe Ile Lys Lys  Glu Gly Asp 
    1115                 1120                 1125             


Lys Pro  Lys Leu Lys Phe 
    1130                 


<210> 468
<211> 1392
<212> PRT
<213> Streptococcus mitis


<220>
<223> Streptococcus mitis SK321

<400> 468
Met Asn Asn Asn Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Ala Thr Ala Glu Asp Arg Arg 
    50                  55                  60                  


Phe Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ala Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Ser Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Ile Leu Lys Leu Phe Ala Tyr Glu Lys Ser Thr Asp Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Ala Leu 
                325                 330                 335     


Lys Gln Phe Ile Gln Asn Asn Leu Gln Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Arg Tyr Ile Asn Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Ile Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Tyr Lys Glu Lys Ile Glu Thr Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asn Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Gln Ala Ser Ser Ala Glu Glu Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ser Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Gln Tyr Leu His Asn Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asp Pro Lys Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Ala 
625                 630                 635                 640 


Ser Ile Phe Asp Lys Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Cys Asp 
            660                 665                 670         


Lys Lys Thr Gly Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Tyr 
        675                 680                 685             


Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Asp Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asn Asp Val 
705                 710                 715                 720 


Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Leu Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Ala Pro Glu Ser Ile Val Ile Glu Ile Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ala Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Asn Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asp 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Val Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Gln 
865                 870                 875                 880 


Lys Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu His Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp 
            900                 905                 910         


Glu Arg Asp Lys Val Gly Phe Ile Arg Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Thr 
    930                 935                 940                 


Glu Val Asn Glu Lys Asp Lys Lys Asn Arg Thr Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Lys Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Gly  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Ile Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Arg Ser Lys Asp  Pro Lys Glu Val Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Thr Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Ala Thr Ile Lys Lys  Val Leu Ser Leu Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Thr Glu Ile  Gln Thr His Gly Leu  Asp Arg Gly 
    1100                 1105                 1110             


Lys Pro  Arg Gly Leu Phe Asn  Ser Asn Pro Ser Pro  Lys Pro Ser 
    1115                 1120                 1125             


Glu Asp  Arg Lys Glu Asn Leu  Val Pro Ile Lys Gln  Gly Leu Asp 
    1130                 1135                 1140             


Pro Arg  Lys Tyr Gly Gly Tyr  Ala Gly Ile Ser Asn  Ser Tyr Ala 
    1145                 1150                 1155             


Val Leu  Val Lys Ala Ile Ile  Glu Lys Gly Ala Lys  Lys Gln Gln 
    1160                 1165                 1170             


Lys Thr  Val Leu Glu Phe Gln  Gly Ile Ser Ile Leu  Asp Lys Ile 
    1175                 1180                 1185             


Asn Phe  Glu Lys Asn Lys Glu  Asn Tyr Leu Leu Glu  Lys Gly Tyr 
    1190                 1195                 1200             


Ile Lys  Ile Leu Ser Thr Ile  Thr Leu Pro Lys Tyr  Ser Leu Phe 
    1205                 1210                 1215             


Glu Phe  Pro Asp Gly Thr Arg  Arg Arg Leu Ala Ser  Ile Leu Ser 
    1220                 1225                 1230             


Thr Asn  Asn Lys Arg Gly Glu  Ile His Lys Gly Asn  Glu Leu Val 
    1235                 1240                 1245             


Ile Pro  Glu Lys Tyr Thr Thr  Leu Leu Tyr His Ala  Lys Asn Ile 
    1250                 1255                 1260             


Asn Lys  Thr Leu Glu Pro Glu  His Leu Glu Tyr Val  Glu Lys His 
    1265                 1270                 1275             


Arg Asn  Asp Phe Ala Lys Leu  Leu Glu Tyr Val Leu  Asn Phe Asn 
    1280                 1285                 1290             


Asp Lys  Tyr Val Gly Ala Leu  Lys Asn Gly Glu Arg  Ile Arg Gln 
    1295                 1300                 1305             


Ala Phe  Ile Asp Trp Glu Thr  Val Asp Ile Glu Lys  Leu Cys Phe 
    1310                 1315                 1320             


Ser Phe  Ile Gly Pro Arg Asn  Ser Lys Asn Ala Gly  Leu Phe Glu 
    1325                 1330                 1335             


Leu Thr  Ser Gln Gly Ser Ala  Ser Asp Phe Glu Phe  Leu Gly Val 
    1340                 1345                 1350             


Lys Ile  Pro Arg Tyr Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Asn 
    1355                 1360                 1365             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1370                 1375                 1380             


Ile Asp  Leu Ser Lys Leu Gly  Glu Asp 
    1385                 1390         


<210> 469
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 11SSST2

<400> 469
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Thr Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Leu Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ser Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 470
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 11SSST2

<400> 470
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Thr Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Leu Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ser Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 471
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 11VS1

<400> 471
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 472
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 14D

<400> 472
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 473
<211> 1355
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 15VF2

<400> 473
Met Lys Lys Ser Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Ala 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr His Ser Asp Glu Ala Val Met Pro Trp Asn Phe Asp Gln 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Gln Ala Phe Ile Glu His Met Thr 
                485                 490                 495     


Asn Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Thr Glu Ile Gly Glu Ala Lys Phe Phe Asp Ala Asn Leu Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Leu Phe Lys His Glu Arg Lys Val Thr Lys 
545                 550                 555                 560 


Lys Lys Leu Arg Thr Phe Leu Asp Lys Asn Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Ile Gln Gly Leu Asp Lys Glu Thr Glu Thr Phe Asn Ala Ser 
            580                 585                 590         


Tyr Ala Thr Tyr Gln Asp Leu Leu Lys Val Ile Lys Asp Lys Val Phe 
        595                 600                 605             


Met Asp Asn Pro Glu Asn Ala Glu Ile Leu Glu Asn Ile Val Leu Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Lys 
625                 630                 635                 640 


Tyr Ala Asp Val Phe Asp Lys Lys Val Ile Asp Gln Leu Ala Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Gln Ser Cys Lys Thr Ile Met Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Ala Gln Ser Asn Arg Asn Leu Met Gln Leu Ile Thr Asp Asp Asn Leu 
    690                 695                 700                 


Thr Phe Lys Asp Asp Ile Val Lys Ala Gln Tyr Val Asp Asn Ser Asp 
705                 710                 715                 720 


Asp Leu His Gln Val Val Gln Ser Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Lys Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Lys Gly Arg Arg Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Leu Lys Glu Ala Ile Lys Ser Leu Asp Arg Asp Leu Asn His Lys Ile 
785                 790                 795                 800 


Leu Lys Glu His Pro Thr Asp Asn Gln Ala Leu Gln Asn Asn Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ser 
            820                 825                 830         


Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Ile Asp His Val Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Ser Lys Ala Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val 
865                 870                 875                 880 


Val Asn Arg Met Arg Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Pro 
            900                 905                 910         


Asp Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu 
    930                 935                 940                 


Phe Asp Asp Asn Asn Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Val Lys Ala Leu Leu  Val Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu 
    1010                 1015                 1020             


Arg Lys  Thr Ala Thr Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met 
    1025                 1030                 1035             


Asn Met  Phe Lys Ser Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val 
    1040                 1045                 1050             


Glu Arg  Pro Met Ile Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala 
    1055                 1060                 1065             


Trp Asp  Lys Thr Lys His Ile  Thr Thr Val Lys Lys  Val Leu Ser 
    1070                 1075                 1080             


Tyr Pro  Gln Val Asn Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile 
    1085                 1090                 1095             


Gly Gln  Asn Gly Gly Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu 
    1100                 1105                 1110             


Glu Val  Ile Pro Ser Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn 
    1115                 1120                 1125             


Pro Glu  Lys Tyr Gly Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro 
    1130                 1135                 1140             


Ile Leu  Leu Ile Val Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val 
    1145                 1150                 1155             


Met Asp  Lys Lys Arg Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys 
    1160                 1165                 1170             


Asp Lys  Gly Tyr Gln Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu 
    1175                 1180                 1185             


Pro Lys  Tyr Thr Leu Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu 
    1190                 1195                 1200             


Trp Ala  Ser Ser Lys Glu Val  His Lys Gly Asn Gln  Leu Val Val 
    1205                 1210                 1215             


Ser Lys  Lys Ser Gln Asp Leu  Leu Tyr His Ala His  His Leu Asp 
    1220                 1225                 1230             


Asn Asp  Tyr Ser Asn Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe 
    1235                 1240                 1245             


Asp Ile  Leu Phe Asn Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys 
    1250                 1255                 1260             


Leu Gly  Lys Glu His Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys 
    1265                 1270                 1275             


Glu Arg  Asp Ser Ala Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile 
    1280                 1285                 1290             


Lys Leu  Leu Gly Phe Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser 
    1295                 1300                 1305             


Phe Leu  Gly Ile Lys Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys 
    1310                 1315                 1320             


Asp Tyr  Leu Leu Pro Cys Met  Glu Ala Thr Leu Ile  His Gln Ser 
    1325                 1330                 1335             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Asn  Lys Leu Gly 
    1340                 1345                 1350             


Gly Asp  
    1355 


<210> 474
<211> 1355
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 15VF2

<400> 474
Met Lys Lys Ser Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Ala 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr His Ser Asp Glu Ala Val Met Pro Trp Asn Phe Asp Gln 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Gln Ala Phe Ile Glu His Met Thr 
                485                 490                 495     


Asn Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Thr Glu Ile Gly Glu Ala Lys Phe Phe Asp Ala Asn Leu Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Leu Phe Lys His Glu Arg Lys Val Thr Lys 
545                 550                 555                 560 


Lys Lys Leu Arg Thr Phe Leu Asp Lys Asn Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Ile Gln Gly Leu Asp Lys Glu Thr Glu Thr Phe Asn Ala Ser 
            580                 585                 590         


Tyr Ala Thr Tyr Gln Asp Leu Leu Lys Val Ile Lys Asp Lys Val Phe 
        595                 600                 605             


Met Asp Asn Pro Glu Asn Ala Glu Ile Leu Glu Asn Ile Val Leu Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Lys 
625                 630                 635                 640 


Tyr Ala Asp Val Phe Asp Lys Lys Val Ile Asp Gln Leu Ala Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Gln Ser Cys Lys Thr Ile Met Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Ala Gln Ser Asn Arg Asn Leu Met Gln Leu Ile Thr Asp Asp Asn Leu 
    690                 695                 700                 


Thr Phe Lys Asp Asp Ile Val Lys Ala Gln Tyr Val Asp Asn Ser Asp 
705                 710                 715                 720 


Asp Leu His Gln Val Val Gln Ser Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Lys Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Lys Gly Arg Arg Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Leu Lys Glu Ala Ile Lys Ser Leu Asp Arg Asp Leu Asn His Lys Ile 
785                 790                 795                 800 


Leu Lys Glu His Pro Thr Asp Asn Gln Ala Leu Gln Asn Asn Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ser 
            820                 825                 830         


Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Ile Asp His Val Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Ser Lys Ala Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val 
865                 870                 875                 880 


Val Asn Arg Met Arg Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Pro 
            900                 905                 910         


Asp Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu 
    930                 935                 940                 


Phe Asp Asp Asn Asn Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Val Lys Ala Leu Leu  Val Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu 
    1010                 1015                 1020             


Arg Lys  Thr Ala Thr Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met 
    1025                 1030                 1035             


Asn Met  Phe Lys Ser Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val 
    1040                 1045                 1050             


Glu Arg  Pro Met Ile Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala 
    1055                 1060                 1065             


Trp Asp  Lys Thr Lys His Ile  Thr Thr Val Lys Lys  Val Leu Ser 
    1070                 1075                 1080             


Tyr Pro  Gln Val Asn Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile 
    1085                 1090                 1095             


Gly Gln  Asn Gly Gly Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu 
    1100                 1105                 1110             


Glu Val  Ile Pro Ser Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn 
    1115                 1120                 1125             


Pro Glu  Lys Tyr Gly Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro 
    1130                 1135                 1140             


Ile Leu  Leu Ile Val Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val 
    1145                 1150                 1155             


Met Asp  Lys Lys Arg Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys 
    1160                 1165                 1170             


Asp Lys  Gly Tyr Gln Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu 
    1175                 1180                 1185             


Pro Lys  Tyr Thr Leu Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu 
    1190                 1195                 1200             


Trp Ala  Ser Ser Lys Glu Val  His Lys Gly Asn Gln  Leu Val Val 
    1205                 1210                 1215             


Ser Lys  Lys Ser Gln Asp Leu  Leu Tyr His Ala His  His Leu Asp 
    1220                 1225                 1230             


Asn Asp  Tyr Ser Asn Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe 
    1235                 1240                 1245             


Asp Ile  Leu Phe Asn Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys 
    1250                 1255                 1260             


Leu Gly  Lys Glu His Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys 
    1265                 1270                 1275             


Glu Arg  Asp Ser Ala Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile 
    1280                 1285                 1290             


Lys Leu  Leu Gly Phe Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser 
    1295                 1300                 1305             


Phe Leu  Gly Ile Lys Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys 
    1310                 1315                 1320             


Asp Tyr  Leu Leu Pro Cys Met  Glu Ala Thr Leu Ile  His Gln Ser 
    1325                 1330                 1335             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Asn  Lys Leu Gly 
    1340                 1345                 1350             


Gly Asp  
    1355 


<210> 475
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 1SM1

<400> 475
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 476
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 1SM1

<400> 476
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 477
<211> 1350
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 24

<400> 477
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Gln Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Asn Arg Met Arg 
865                 870                 875                 880 


Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu Ile Ser Gln Arg Lys 
                885                 890                 895     


Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu Asp Asp Lys Ala Gly 
            900                 905                 910         


Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 
        915                 920                 925             


Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu Phe Asp Asp Asn Asn 
    930                 935                 940                 


Lys Arg Ile Cys Lys Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val 
945                 950                 955                 960 


Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn 
                965                 970                 975     


Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Val Lys 
            980                 985                 990         


Ala Leu Leu Val Lys Tyr Ser Lys  Leu Glu Pro Glu Phe  Val Tyr Gly 
        995                 1000                 1005             


Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu Arg Lys  Thr Ala Thr 
    1010                 1015                 1020             


Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met Asn Met  Phe Lys Ser 
    1025                 1030                 1035             


Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val Glu Arg  Pro Met Ile 
    1040                 1045                 1050             


Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala Trp Asp  Lys Thr Lys 
    1055                 1060                 1065             


His Ile  Thr Thr Val Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1070                 1075                 1080             


Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile Gly Gln  Asn Gly Gly 
    1085                 1090                 1095             


Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu Glu Val  Ile Pro Ser 
    1100                 1105                 1110             


Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn Pro Glu  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro Ile Leu  Leu Ile Val 
    1130                 1135                 1140             


Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val Met Asp  Lys Lys Arg 
    1145                 1150                 1155             


Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys Asp Lys  Gly Tyr Gln 
    1160                 1165                 1170             


Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu Pro Lys  Tyr Thr Leu 
    1175                 1180                 1185             


Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu Trp Ala  Ser Ser Lys 
    1190                 1195                 1200             


Glu Val  His Lys Gly Asn Gln  Leu Val Val Ser Lys  Lys Ser Gln 
    1205                 1210                 1215             


Asp Leu  Leu Tyr His Ala His  His Leu Asp Asn Asp  Tyr Ser Asn 
    1220                 1225                 1230             


Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe Asp Ile  Leu Phe Asn 
    1235                 1240                 1245             


Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys Leu Gly  Lys Glu His 
    1250                 1255                 1260             


Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys Glu Arg  Asp Ser Ala 
    1265                 1270                 1275             


Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile Lys Leu  Leu Gly Phe 
    1280                 1285                 1290             


Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser Phe Leu  Gly Ile Lys 
    1295                 1300                 1305             


Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys Asp Tyr  Leu Leu Pro 
    1310                 1315                 1320             


Cys Met  Glu Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1325                 1330                 1335             


Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345                 1350 


<210> 478
<211> 1350
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 24

<400> 478
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Gln Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Asn Arg Met Arg 
865                 870                 875                 880 


Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu Ile Ser Gln Arg Lys 
                885                 890                 895     


Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu Asp Asp Lys Ala Gly 
            900                 905                 910         


Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 
        915                 920                 925             


Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu Phe Asp Asp Asn Asn 
    930                 935                 940                 


Lys Arg Ile Cys Lys Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val 
945                 950                 955                 960 


Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn 
                965                 970                 975     


Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Val Lys 
            980                 985                 990         


Ala Leu Leu Val Lys Tyr Ser Lys  Leu Glu Pro Glu Phe  Val Tyr Gly 
        995                 1000                 1005             


Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu Arg Lys  Thr Ala Thr 
    1010                 1015                 1020             


Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met Asn Met  Phe Lys Ser 
    1025                 1030                 1035             


Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val Glu Arg  Pro Met Ile 
    1040                 1045                 1050             


Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala Trp Asp  Lys Thr Lys 
    1055                 1060                 1065             


His Ile  Thr Thr Val Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1070                 1075                 1080             


Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile Gly Gln  Asn Gly Gly 
    1085                 1090                 1095             


Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu Glu Val  Ile Pro Ser 
    1100                 1105                 1110             


Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn Pro Glu  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro Ile Leu  Leu Ile Val 
    1130                 1135                 1140             


Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val Met Asp  Lys Lys Arg 
    1145                 1150                 1155             


Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys Asp Lys  Gly Tyr Gln 
    1160                 1165                 1170             


Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu Pro Lys  Tyr Thr Leu 
    1175                 1180                 1185             


Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu Trp Ala  Ser Ser Lys 
    1190                 1195                 1200             


Glu Val  His Lys Gly Asn Gln  Leu Val Val Ser Lys  Lys Ser Gln 
    1205                 1210                 1215             


Asp Leu  Leu Tyr His Ala His  His Leu Asp Asn Asp  Tyr Ser Asn 
    1220                 1225                 1230             


Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe Asp Ile  Leu Phe Asn 
    1235                 1240                 1245             


Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys Leu Gly  Lys Glu His 
    1250                 1255                 1260             


Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys Glu Arg  Asp Ser Ala 
    1265                 1270                 1275             


Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile Lys Leu  Leu Gly Phe 
    1280                 1285                 1290             


Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser Phe Leu  Gly Ile Lys 
    1295                 1300                 1305             


Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys Asp Tyr  Leu Leu Pro 
    1310                 1315                 1320             


Cys Met  Glu Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1325                 1330                 1335             


Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345                 1350 


<210> 479
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 2VS1

<400> 479
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 480
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 2VS1

<400> 480
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 481
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 3SN1

<400> 481
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 482
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 3SN1

<400> 482
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 483
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 4SM1

<400> 483
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 484
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 4SM1

<400> 484
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 485
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 4VF1

<400> 485
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Arg Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 486
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 4VF1

<400> 486
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Arg Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 487
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 5SM3

<400> 487
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Phe Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ser Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Glu Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 488
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 5SM3

<400> 488
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Phe Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ser Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Glu Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 489
<211> 1359
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 66-2A

<400> 489
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Met Gln Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Arg Tyr Pro Ile Phe Gly Thr Leu Lys Glu Glu Lys Lys Tyr 
        115                 120                 125             


His Lys Glu Phe Lys Thr Ile Tyr His Leu Arg Glu Lys Leu Ala Asn 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ser Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asn Val Gln Ala Leu Phe Lys Asp Phe Val Glu Val Tyr 
            180                 185                 190         


Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Met Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Val Glu Cys Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Leu Leu Gly Glu Ile Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Ala Val Asp Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Lys Glu His Lys Glu Glu Leu Ala Ala Phe Lys 
                325                 330                 335     


Arg Phe Ile Lys Glu Lys Leu Pro Lys Lys Tyr Glu Glu Ile Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ala Asp Lys Lys 
        355                 360                 365             


Leu Arg Lys Arg Ser Gly Lys Leu Ala Thr Glu Glu Glu Phe Tyr Lys 
    370                 375                 380                 


Tyr Val Lys Gly Ile Leu Asn Lys Val Glu Gly Ala Asp Val Trp Leu 
385                 390                 395                 400 


Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp 
                405                 410                 415     


Asn Gly Ser Ile Pro His Gln Ile His Leu Gln Glu Met His Ala Ile 
            420                 425                 430         


Leu Arg Arg Gln Gly Glu His Tyr Pro Phe Leu Lys Glu Asn Gln Asp 
        435                 440                 445             


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
    450                 455                 460                 


Leu Val Arg Lys Gly Ser Arg Phe Ala Trp Ala Glu Tyr Lys Ala Asp 
465                 470                 475                 480 


Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp Ile Leu Asp Lys Glu Lys 
                485                 490                 495     


Ser Ala Glu Lys Phe Ile Thr Arg Met Thr Leu Asn Asp Leu Tyr Leu 
            500                 505                 510         


Pro Glu Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Thr Phe 
        515                 520                 525             


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Asn Glu Gln Gly 
    530                 535                 540                 


Glu Ala Lys Phe Phe Asp Ala Asn Met Lys Gln Glu Ile Phe Asp His 
545                 550                 555                 560 


Val Phe Lys Glu Asn Arg Lys Val Thr Lys Asp Lys Leu Leu Asn Tyr 
                565                 570                 575     


Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile Val Asn Leu Thr Gly Leu 
            580                 585                 590         


Asp Lys Glu Asn Lys Val Phe Asn Ser Ser Leu Gly Thr Tyr His Asp 
        595                 600                 605             


Leu Arg Lys Ile Leu Asn Lys Ser Phe Leu Asp Asn Lys Glu Asn Glu 
    610                 615                 620                 


Gln Ile Ile Glu Asp Ile Ile Gln Thr Leu Thr Leu Phe Glu Asp Arg 
625                 630                 635                 640 


Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr Ser Asp Ile Phe Thr Lys 
                645                 650                 655     


Ala Gln Leu Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg 
            660                 665                 670         


Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Asn Lys 
        675                 680                 685             


Thr Ile Leu Gly Tyr Leu Ile Asp Asp Gly Tyr Ser Asn Arg Asn Phe 
    690                 695                 700                 


Met Gln Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala 
705                 710                 715                 720 


Lys Ala Gln Val Ile Gly Glu Met Asp Gly Leu Asn Gln Val Val Ser 
                725                 730                 735     


Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu 
            740                 745                 750         


Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His Asn Pro Ala Asn 
        755                 760                 765             


Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Ala Lys Gly Arg 
    770                 775                 780                 


Arg Ser Ser Gln Lys Arg Tyr Lys Arg Leu Glu Glu Ala Ile Lys Asn 
785                 790                 795                 800 


Leu Asp His Asp Leu Asn His Lys Ile Leu Lys Glu His Pro Thr Asp 
                805                 810                 815     


Asn Gln Ala Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu Gln Asn 
            820                 825                 830         


Gly Arg Asp Met Tyr Thr Glu Asp Pro Leu Asp Ile Asn Arg Leu Ser 
        835                 840                 845             


Asp Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn 
    850                 855                 860                 


Ser Ile Asp Asn Arg Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys 
865                 870                 875                 880 


Ser Asp Asp Val Pro Ser Glu Glu Val Val His Lys Met Lys Pro Phe 
                885                 890                 895     


Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp 
            900                 905                 910         


Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp Lys Ala 
        915                 920                 925             


Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His 
    930                 935                 940                 


Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp Glu Asn 
945                 950                 955                 960 


Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser Asn Leu 
                965                 970                 975     


Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile 
            980                 985                 990         


Asn Asp Tyr His His Ala His Asp  Ala Tyr Leu Asn Ala  Val Ile Gly 
        995                 1000                 1005             


Lys Ala  Leu Leu Gly Val Tyr  Pro Gln Leu Glu Pro  Glu Phe Val 
    1010                 1015                 1020             


Tyr Gly  Asp Tyr Pro His Phe  His Gly His Lys Glu  Asn Lys Ala 
    1025                 1030                 1035             


Thr Ala  Lys Lys Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1040                 1045                 1050             


Lys Gly  Asp Val Arg Thr Asp  Lys Asn Gly Glu Ile  Ile Trp Lys 
    1055                 1060                 1065             


Lys Asp  Glu His Ile Ser Asn  Ile Lys Lys Val Leu  Ser Tyr Pro 
    1070                 1075                 1080             


Gln Val  Asn Ile Val Lys Lys  Val Glu Glu Gln Thr  Gly Gly Phe 
    1085                 1090                 1095             


Ser Lys  Glu Ser Ile Leu Pro  Lys Gly Asn Ser Asp  Lys Leu Ile 
    1100                 1105                 1110             


Pro Arg  Lys Thr Lys Lys Phe  Tyr Trp Asp Thr Lys  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser Ile Leu  Val Ile Ala 
    1130                 1135                 1140             


Asp Ile  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Thr  Val Lys Ala 
    1145                 1150                 1155             


Leu Val  Gly Val Thr Ile Met  Glu Lys Met Thr Phe  Glu Arg Asp 
    1160                 1165                 1170             


Pro Val  Ala Phe Leu Glu Arg  Lys Gly Tyr Arg Asn  Val Gln Glu 
    1175                 1180                 1185             


Glu Asn  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Lys Leu Glu 
    1190                 1195                 1200             


Asn Gly  Arg Lys Arg Leu Leu  Ala Ser Ala Arg Glu  Leu Gln Lys 
    1205                 1210                 1215             


Gly Asn  Glu Ile Val Leu Pro  Asn His Leu Glu Thr  Leu Leu Tyr 
    1220                 1225                 1230             


His Ala  Lys Asn Ile His Lys  Val Asp Glu Pro Lys  His Leu Asp 
    1235                 1240                 1245             


Tyr Val  Asp Lys His Lys Asp  Glu Phe Lys Glu Leu  Leu Asp Val 
    1250                 1255                 1260             


Val Ser  Asn Phe Ser Lys Lys  Tyr Thr Leu Ala Glu  Gly Asn Leu 
    1265                 1270                 1275             


Glu Lys  Ile Lys Glu Leu Tyr  Ala Gln Asn Asn Gly  Glu Asp Leu 
    1280                 1285                 1290             


Lys Glu  Leu Ala Ser Ser Phe  Ile Asn Leu Leu Thr  Phe Thr Ala 
    1295                 1300                 1305             


Ile Gly  Ala Pro Ala Ala Phe  Lys Phe Phe Asp Lys  Asn Ile Asp 
    1310                 1315                 1320             


Arg Lys  Arg Tyr Thr Ser Thr  Thr Glu Ile Leu Asn  Ala Thr Leu 
    1325                 1330                 1335             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1340                 1345                 1350             


Asn Lys  Leu Gly Gly Asp 
    1355                 


<210> 490
<211> 1359
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 66-2A

<400> 490
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Met Gln Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Arg Tyr Pro Ile Phe Gly Thr Leu Lys Glu Glu Lys Lys Tyr 
        115                 120                 125             


His Lys Glu Phe Lys Thr Ile Tyr His Leu Arg Glu Lys Leu Ala Asn 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ser Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asn Val Gln Ala Leu Phe Lys Asp Phe Val Glu Val Tyr 
            180                 185                 190         


Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Met Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Val Glu Cys Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Leu Leu Gly Glu Ile Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Ala Val Asp Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Lys Glu His Lys Glu Glu Leu Ala Ala Phe Lys 
                325                 330                 335     


Arg Phe Ile Lys Glu Lys Leu Pro Lys Lys Tyr Glu Glu Ile Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ala Asp Lys Lys 
        355                 360                 365             


Leu Arg Lys Arg Ser Gly Lys Leu Ala Thr Glu Glu Glu Phe Tyr Lys 
    370                 375                 380                 


Tyr Val Lys Gly Ile Leu Asn Lys Val Glu Gly Ala Asp Val Trp Leu 
385                 390                 395                 400 


Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp 
                405                 410                 415     


Asn Gly Ser Ile Pro His Gln Ile His Leu Gln Glu Met His Ala Ile 
            420                 425                 430         


Leu Arg Arg Gln Gly Glu His Tyr Pro Phe Leu Lys Glu Asn Gln Asp 
        435                 440                 445             


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
    450                 455                 460                 


Leu Val Arg Lys Gly Ser Arg Phe Ala Trp Ala Glu Tyr Lys Ala Asp 
465                 470                 475                 480 


Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp Ile Leu Asp Lys Glu Lys 
                485                 490                 495     


Ser Ala Glu Lys Phe Ile Thr Arg Met Thr Leu Asn Asp Leu Tyr Leu 
            500                 505                 510         


Pro Glu Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Thr Phe 
        515                 520                 525             


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Asn Glu Gln Gly 
    530                 535                 540                 


Glu Ala Lys Phe Phe Asp Ala Asn Met Lys Gln Glu Ile Phe Asp His 
545                 550                 555                 560 


Val Phe Lys Glu Asn Arg Lys Val Thr Lys Asp Lys Leu Leu Asn Tyr 
                565                 570                 575     


Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile Val Asn Leu Thr Gly Leu 
            580                 585                 590         


Asp Lys Glu Asn Lys Val Phe Asn Ser Ser Leu Gly Thr Tyr His Asp 
        595                 600                 605             


Leu Arg Lys Ile Leu Asn Lys Ser Phe Leu Asp Asn Lys Glu Asn Glu 
    610                 615                 620                 


Gln Ile Ile Glu Asp Ile Ile Gln Thr Leu Thr Leu Phe Glu Asp Arg 
625                 630                 635                 640 


Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr Ser Asp Ile Phe Thr Lys 
                645                 650                 655     


Ala Gln Leu Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg 
            660                 665                 670         


Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Asn Lys 
        675                 680                 685             


Thr Ile Leu Gly Tyr Leu Ile Asp Asp Gly Tyr Ser Asn Arg Asn Phe 
    690                 695                 700                 


Met Gln Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala 
705                 710                 715                 720 


Lys Ala Gln Val Ile Gly Glu Met Asp Gly Leu Asn Gln Val Val Ser 
                725                 730                 735     


Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu 
            740                 745                 750         


Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His Asn Pro Ala Asn 
        755                 760                 765             


Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Ala Lys Gly Arg 
    770                 775                 780                 


Arg Ser Ser Gln Lys Arg Tyr Lys Arg Leu Glu Glu Ala Ile Lys Asn 
785                 790                 795                 800 


Leu Asp His Asp Leu Asn His Lys Ile Leu Lys Glu His Pro Thr Asp 
                805                 810                 815     


Asn Gln Ala Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu Gln Asn 
            820                 825                 830         


Gly Arg Asp Met Tyr Thr Glu Asp Pro Leu Asp Ile Asn Arg Leu Ser 
        835                 840                 845             


Asp Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn 
    850                 855                 860                 


Ser Ile Asp Asn Arg Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys 
865                 870                 875                 880 


Ser Asp Asp Val Pro Ser Glu Glu Val Val His Lys Met Lys Pro Phe 
                885                 890                 895     


Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp 
            900                 905                 910         


Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp Lys Ala 
        915                 920                 925             


Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His 
    930                 935                 940                 


Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp Glu Asn 
945                 950                 955                 960 


Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser Asn Leu 
                965                 970                 975     


Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile 
            980                 985                 990         


Asn Asp Tyr His His Ala His Asp  Ala Tyr Leu Asn Ala  Val Ile Gly 
        995                 1000                 1005             


Lys Ala  Leu Leu Gly Val Tyr  Pro Gln Leu Glu Pro  Glu Phe Val 
    1010                 1015                 1020             


Tyr Gly  Asp Tyr Pro His Phe  His Gly His Lys Glu  Asn Lys Ala 
    1025                 1030                 1035             


Thr Ala  Lys Lys Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1040                 1045                 1050             


Lys Gly  Asp Val Arg Thr Asp  Lys Asn Gly Glu Ile  Ile Trp Lys 
    1055                 1060                 1065             


Lys Asp  Glu His Ile Ser Asn  Ile Lys Lys Val Leu  Ser Tyr Pro 
    1070                 1075                 1080             


Gln Val  Asn Ile Val Lys Lys  Val Glu Glu Gln Thr  Gly Gly Phe 
    1085                 1090                 1095             


Ser Lys  Glu Ser Ile Leu Pro  Lys Gly Asn Ser Asp  Lys Leu Ile 
    1100                 1105                 1110             


Pro Arg  Lys Thr Lys Lys Phe  Tyr Trp Asp Thr Lys  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser Ile Leu  Val Ile Ala 
    1130                 1135                 1140             


Asp Ile  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Thr  Val Lys Ala 
    1145                 1150                 1155             


Leu Val  Gly Val Thr Ile Met  Glu Lys Met Thr Phe  Glu Arg Asp 
    1160                 1165                 1170             


Pro Val  Ala Phe Leu Glu Arg  Lys Gly Tyr Arg Asn  Val Gln Glu 
    1175                 1180                 1185             


Glu Asn  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Lys Leu Glu 
    1190                 1195                 1200             


Asn Gly  Arg Lys Arg Leu Leu  Ala Ser Ala Arg Glu  Leu Gln Lys 
    1205                 1210                 1215             


Gly Asn  Glu Ile Val Leu Pro  Asn His Leu Glu Thr  Leu Leu Tyr 
    1220                 1225                 1230             


His Ala  Lys Asn Ile His Lys  Val Asp Glu Pro Lys  His Leu Asp 
    1235                 1240                 1245             


Tyr Val  Asp Lys His Lys Asp  Glu Phe Lys Glu Leu  Leu Asp Val 
    1250                 1255                 1260             


Val Ser  Asn Phe Ser Lys Lys  Tyr Thr Leu Ala Glu  Gly Asn Leu 
    1265                 1270                 1275             


Glu Lys  Ile Lys Glu Leu Tyr  Ala Gln Asn Asn Gly  Glu Asp Leu 
    1280                 1285                 1290             


Lys Glu  Leu Ala Ser Ser Phe  Ile Asn Leu Leu Thr  Phe Thr Ala 
    1295                 1300                 1305             


Ile Gly  Ala Pro Ala Ala Phe  Lys Phe Phe Asp Lys  Asn Ile Asp 
    1310                 1315                 1320             


Arg Lys  Arg Tyr Thr Ser Thr  Thr Glu Ile Leu Asn  Ala Thr Leu 
    1325                 1330                 1335             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1340                 1345                 1350             


Asn Lys  Leu Gly Gly Asp 
    1355                 


<210> 491
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 8ID3

<400> 491
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Ile Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 492
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 8ID3

<400> 492
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Ile Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 493
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans A19

<400> 493
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Ile  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 494
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans A19

<400> 494
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Ile  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 495
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans B

<400> 495
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 496
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans G123

<400> 496
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 497
<211> 1345
<212> PRT
<213> Streptococcus mutans

<400> 497
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 498
<211> 1345
<212> PRT
<213> Streptococcus mutans

<400> 498
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Asp Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 499
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans M21

<400> 499
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 500
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans M21

<400> 500
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 501
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans M230

<400> 501
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Gln Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 502
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans M230

<400> 502
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Gln Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 503
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans M2A

<400> 503
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Tyr Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 504
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans M2A

<400> 504
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Tyr Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 505
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans N29

<400> 505
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ser Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 506
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans N29

<400> 506
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ser Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 507
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans N3209

<400> 507
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Thr Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Cys Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Ser Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 508
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans N3209

<400> 508
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Thr Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Cys Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Ser Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 509
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans N66

<400> 509
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Leu Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Phe  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 510
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans N66

<400> 510
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Leu Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Phe  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 511
<211> 1350
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NFSM1

<400> 511
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Thr Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Thr Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Asn Arg Met Arg 
865                 870                 875                 880 


Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu Ile Ser Gln Arg Lys 
                885                 890                 895     


Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Pro Asp Asp Lys Ala Gly 
            900                 905                 910         


Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 
        915                 920                 925             


Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu Phe Asp Asp Asn Asn 
    930                 935                 940                 


Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val 
945                 950                 955                 960 


Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn 
                965                 970                 975     


Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Val Lys 
            980                 985                 990         


Ala Leu Leu Val Lys Tyr Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly 
        995                 1000                 1005             


Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu Arg Lys  Thr Ala Thr 
    1010                 1015                 1020             


Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met Asn Met  Phe Lys Ser 
    1025                 1030                 1035             


Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val Glu Arg  Pro Met Ile 
    1040                 1045                 1050             


Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala Trp Asp  Lys Thr Lys 
    1055                 1060                 1065             


His Ile  Thr Thr Val Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1070                 1075                 1080             


Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile Gly Gln  Asn Gly Gly 
    1085                 1090                 1095             


Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu Glu Val  Ile Pro Ser 
    1100                 1105                 1110             


Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn Pro Glu  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro Ile Leu  Leu Ile Val 
    1130                 1135                 1140             


Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val Met Asp  Lys Lys Arg 
    1145                 1150                 1155             


Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys Asp Lys  Gly Tyr Gln 
    1160                 1165                 1170             


Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu Pro Lys  Tyr Thr Leu 
    1175                 1180                 1185             


Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu Trp Ala  Ser Ser Lys 
    1190                 1195                 1200             


Glu Val  His Lys Gly Asn Gln  Leu Val Val Ser Lys  Lys Ser Gln 
    1205                 1210                 1215             


Asp Leu  Leu Tyr His Ala His  His Leu Asp Asn Asp  Tyr Ser Asn 
    1220                 1225                 1230             


Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe Asp Ile  Leu Phe Asn 
    1235                 1240                 1245             


Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys Leu Gly  Lys Glu His 
    1250                 1255                 1260             


Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys Glu Arg  Asp Ser Ala 
    1265                 1270                 1275             


Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile Lys Leu  Leu Gly Phe 
    1280                 1285                 1290             


Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser Phe Leu  Gly Ile Lys 
    1295                 1300                 1305             


Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys Asp Tyr  Leu Leu Pro 
    1310                 1315                 1320             


Cys Met  Glu Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1325                 1330                 1335             


Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345                 1350 


<210> 512
<211> 1350
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NFSM1

<400> 512
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Thr Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Thr Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Asn Arg Met Arg 
865                 870                 875                 880 


Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu Ile Ser Gln Arg Lys 
                885                 890                 895     


Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Pro Asp Asp Lys Ala Gly 
            900                 905                 910         


Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 
        915                 920                 925             


Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu Phe Asp Asp Asn Asn 
    930                 935                 940                 


Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val 
945                 950                 955                 960 


Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn 
                965                 970                 975     


Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Val Lys 
            980                 985                 990         


Ala Leu Leu Val Lys Tyr Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly 
        995                 1000                 1005             


Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu Arg Lys  Thr Ala Thr 
    1010                 1015                 1020             


Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met Asn Met  Phe Lys Ser 
    1025                 1030                 1035             


Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val Glu Arg  Pro Met Ile 
    1040                 1045                 1050             


Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala Trp Asp  Lys Thr Lys 
    1055                 1060                 1065             


His Ile  Thr Thr Val Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1070                 1075                 1080             


Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile Gly Gln  Asn Gly Gly 
    1085                 1090                 1095             


Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu Glu Val  Ile Pro Ser 
    1100                 1105                 1110             


Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn Pro Glu  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro Ile Leu  Leu Ile Val 
    1130                 1135                 1140             


Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val Met Asp  Lys Lys Arg 
    1145                 1150                 1155             


Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys Asp Lys  Gly Tyr Gln 
    1160                 1165                 1170             


Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu Pro Lys  Tyr Thr Leu 
    1175                 1180                 1185             


Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu Trp Ala  Ser Ser Lys 
    1190                 1195                 1200             


Glu Val  His Lys Gly Asn Gln  Leu Val Val Ser Lys  Lys Ser Gln 
    1205                 1210                 1215             


Asp Leu  Leu Tyr His Ala His  His Leu Asp Asn Asp  Tyr Ser Asn 
    1220                 1225                 1230             


Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe Asp Ile  Leu Phe Asn 
    1235                 1240                 1245             


Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys Leu Gly  Lys Glu His 
    1250                 1255                 1260             


Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys Glu Arg  Asp Ser Ala 
    1265                 1270                 1275             


Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile Lys Leu  Leu Gly Phe 
    1280                 1285                 1290             


Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser Phe Leu  Gly Ile Lys 
    1295                 1300                 1305             


Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys Asp Tyr  Leu Leu Pro 
    1310                 1315                 1320             


Cys Met  Glu Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1325                 1330                 1335             


Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345                 1350 


<210> 513
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NLML1

<400> 513
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Arg Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 514
<211> 1338
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NLML4

<400> 514
Met Asp Leu Ile Gly Thr Asn Ser Val Gly Trp Ala Val Val Thr Asp 
1               5                   10                  15      


Asp Tyr Lys Val Pro Ala Lys Lys Met Lys Val Leu Gly Asn Thr Asp 
            20                  25                  30          


Lys Ser His Ile Lys Lys Asn Leu Leu Gly Ala Leu Leu Phe Asp Ser 
        35                  40                  45              


Gly Asn Thr Ala Ala Asp Arg Arg Leu Lys Arg Thr Ala Arg Arg Arg 
    50                  55                  60                  


Tyr Thr Arg Arg Arg Asn Arg Ile Leu Tyr Leu Gln Glu Ile Phe Ala 
65                  70                  75                  80  


Glu Glu Met Ser Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Asp 
                85                  90                  95      


Ser Phe Leu Val Thr Glu Asp Lys Arg Gly Glu Arg His Pro Ile Phe 
            100                 105                 110         


Gly Asn Leu Glu Glu Glu Val Lys Tyr His Glu Asn Phe Pro Thr Ile 
        115                 120                 125             


Tyr His Leu Arg Gln Tyr Leu Ala Asp Asn Pro Glu Lys Val Asp Leu 
    130                 135                 140                 


Arg Leu Val Tyr Leu Ala Leu Ala His Ile Ile Lys Phe Arg Gly His 
145                 150                 155                 160 


Phe Leu Ile Glu Gly Lys Phe Asp Thr Arg Asn Asn Asp Val Gln Arg 
                165                 170                 175     


Leu Phe Gln Glu Phe Leu Ala Val Tyr Asp Asn Thr Phe Glu Asn Ser 
            180                 185                 190         


Ser Leu Gln Glu Gln Asn Val Gln Val Glu Glu Ile Leu Thr Asp Lys 
        195                 200                 205             


Ile Ser Lys Ser Ala Lys Lys Asp Arg Val Leu Lys Leu Phe Pro Asn 
    210                 215                 220                 


Glu Lys Ser Asn Gly Arg Phe Ala Glu Phe Leu Lys Leu Ile Val Gly 
225                 230                 235                 240 


Asn Gln Ala Asp Phe Lys Lys His Phe Glu Leu Glu Glu Lys Ala Pro 
                245                 250                 255     


Leu Gln Phe Ser Lys Asp Thr Tyr Glu Glu Glu Leu Glu Val Leu Leu 
            260                 265                 270         


Ala Gln Ile Gly Asp Asn Tyr Ala Glu Leu Phe Leu Ser Ala Lys Lys 
        275                 280                 285             


Leu Tyr Asp Ser Ile Leu Leu Ser Gly Ile Leu Thr Val Thr Asp Val 
    290                 295                 300                 


Ser Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Gln Arg Tyr Asn Glu 
305                 310                 315                 320 


His Gln Met Asp Leu Ala Gln Leu Lys Gln Phe Ile Arg Gln Lys Leu 
                325                 330                 335     


Ser Asp Lys Tyr Asn Glu Val Phe Ser Asp Val Ser Lys Asp Gly Tyr 
            340                 345                 350         


Ala Gly Tyr Ile Asp Gly Lys Thr Asn Gln Glu Ala Phe Tyr Lys Tyr 
        355                 360                 365             


Leu Lys Gly Leu Leu Asn Lys Ile Glu Gly Ser Gly Tyr Phe Leu Asp 
    370                 375                 380                 


Lys Ile Glu Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn 
385                 390                 395                 400 


Gly Ser Ile Pro His Gln Ile His Leu Gln Glu Met Arg Ala Ile Ile 
                405                 410                 415     


Arg Arg Gln Ala Glu Phe Tyr Pro Phe Leu Ala Asp Asn Gln Asp Arg 
            420                 425                 430         


Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
        435                 440                 445             


Ala Arg Gly Lys Ser Asp Phe Ala Trp Leu Ser Arg Lys Ser Ala Asp 
    450                 455                 460                 


Lys Ile Thr Pro Trp Asn Phe Asp Glu Ile Val Asp Lys Glu Ser Ser 
465                 470                 475                 480 


Ala Glu Ala Phe Ile Asn Arg Met Thr Asn Tyr Asp Leu Tyr Leu Pro 
                485                 490                 495     


Asn Gln Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Thr 
            500                 505                 510         


Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Lys Thr Glu Gln Gly Lys 
        515                 520                 525             


Thr Ala Phe Phe Asp Ala Asn Met Lys Gln Glu Ile Phe Asp Gly Val 
    530                 535                 540                 


Phe Lys Val Tyr Arg Lys Val Thr Lys Asp Lys Leu Met Asp Phe Leu 
545                 550                 555                 560 


Glu Lys Glu Phe Asp Glu Phe Arg Ile Val Asp Leu Thr Gly Leu Asp 
                565                 570                 575     


Lys Glu Asn Lys Ala Phe Asn Ala Ser Tyr Gly Thr Tyr His Asp Leu 
            580                 585                 590         


Arg Lys Ile Leu Asp Lys Asp Phe Leu Asp Asn Ser Lys Asn Glu Lys 
        595                 600                 605             


Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu 
    610                 615                 620                 


Met Ile Arg Lys Arg Leu Glu Asn Tyr Ser Asp Leu Leu Thr Lys Glu 
625                 630                 635                 640 


Gln Val Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg Leu 
                645                 650                 655     


Ser Ala Glu Leu Ile His Gly Ile Arg Asn Lys Glu Ser Arg Lys Thr 
            660                 665                 670         


Ile Leu Asp Tyr Leu Ile Asp Asp Gly Asn Ser Asn Arg Asn Phe Met 
        675                 680                 685             


Gln Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala Lys 
    690                 695                 700                 


Ala Gln Val Ile Gly Glu Thr Asp Asn Leu Asn Gln Val Val Ser Asp 
705                 710                 715                 720 


Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys 
                725                 730                 735     


Ile Val Asp Glu Leu Val Lys Ile Met Gly His Gln Pro Glu Asn Ile 
            740                 745                 750         


Val Val Glu Met Ala Arg Glu Asn Gln Phe Thr Asn Gln Gly Arg Arg 
        755                 760                 765             


Asn Ser Gln Gln Arg Leu Lys Gly Leu Thr Asp Ser Ile Lys Glu Phe 
    770                 775                 780                 


Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu His Ser Gln Leu Gln 
785                 790                 795                 800 


Asn Asp Arg Leu Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr 
                805                 810                 815     


Thr Gly Glu Glu Leu Asp Ile Asp Tyr Leu Ser Gln Tyr Asp Ile Asp 
            820                 825                 830         


His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg 
        835                 840                 845             


Val Leu Thr Ser Ser Lys Glu Asn Arg Gly Lys Ser Asp Asp Val Pro 
    850                 855                 860                 


Ser Lys Asn Val Val Arg Lys Met Lys Ser Tyr Trp Ser Lys Leu Leu 
865                 870                 875                 880 


Ser Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
                885                 890                 895     


Glu Arg Gly Gly Leu Thr Asp Asp Asp Lys Ala Gly Phe Ile Lys Arg 
            900                 905                 910         


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu 
        915                 920                 925             


Asp Glu Arg Phe His Thr Glu Thr Asp Glu Asn Asn Lys Lys Ile Arg 
    930                 935                 940                 


Gln Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg 
945                 950                 955                 960 


Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His 
                965                 970                 975     


Ala His Asp Ala Tyr Leu Asn Ala Val Ile Gly Lys Ala Leu Leu Gly 
            980                 985                 990         


Val Tyr Pro Gln Leu Glu Pro Glu  Phe Val Tyr Gly Asp  Tyr Pro His 
        995                 1000                 1005             


Phe His  Gly His Lys Glu Asn  Lys Ala Thr Ala Lys  Lys Phe Phe 
    1010                 1015                 1020             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Lys Asp Asp  Val Arg Thr 
    1025                 1030                 1035             


Asp Lys  Asn Gly Glu Ile Ile  Trp Lys Lys Asp Glu  His Ile Ser 
    1040                 1045                 1050             


Asn Ile  Lys Lys Val Leu Ser  Tyr Pro Gln Val Asn  Ile Val Lys 
    1055                 1060                 1065             


Lys Val  Glu Glu Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1070                 1075                 1080             


Pro Lys  Gly Asn Ser Asp Lys  Leu Ile Pro Arg Lys  Thr Lys Lys 
    1085                 1090                 1095             


Phe Tyr  Trp Asp Thr Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Ile 
    1100                 1105                 1110             


Val Ala  Tyr Ser Ile Leu Val  Ile Ala Asp Ile Glu  Lys Gly Lys 
    1115                 1120                 1125             


Ser Lys  Lys Leu Lys Thr Val  Lys Ala Leu Val Gly  Val Thr Ile 
    1130                 1135                 1140             


Met Glu  Lys Met Thr Phe Glu  Arg Asp Pro Val Ala  Phe Leu Glu 
    1145                 1150                 1155             


Arg Lys  Gly Tyr Arg Asn Val  Gln Glu Glu Asn Ile  Ile Lys Leu 
    1160                 1165                 1170             


Pro Lys  Tyr Ser Leu Phe Lys  Leu Glu Asn Gly Arg  Lys Arg Leu 
    1175                 1180                 1185             


Leu Ala  Ser Ala Arg Glu Leu  Gln Lys Gly Asn Glu  Ile Val Leu 
    1190                 1195                 1200             


Pro Asn  His Leu Gly Thr Leu  Leu Tyr His Ala Lys  Asn Ile His 
    1205                 1210                 1215             


Lys Val  Asp Glu Pro Lys His  Leu Asp Tyr Val Asp  Lys His Lys 
    1220                 1225                 1230             


Asp Glu  Phe Lys Glu Leu Leu  Asp Val Val Ser Asn  Phe Ser Lys 
    1235                 1240                 1245             


Lys Tyr  Thr Leu Ala Glu Gly  Asn Leu Glu Lys Ile  Lys Glu Leu 
    1250                 1255                 1260             


Tyr Ala  Gln Asn Asn Gly Glu  Asp Leu Lys Glu Leu  Ala Ser Ser 
    1265                 1270                 1275             


Phe Ile  Asn Leu Leu Thr Phe  Thr Ala Ile Gly Ala  Pro Ala Thr 
    1280                 1285                 1290             


Phe Lys  Phe Phe Asp Lys Asn  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1295                 1300                 1305             


Thr Thr  Glu Ile Leu Asn Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Lys Leu  Gly Gly Asp 
    1325                 1330                 1335             


<210> 515
<211> 1338
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NLML4

<400> 515
Met Asp Leu Ile Gly Thr Asn Ser Val Gly Trp Ala Val Val Thr Asp 
1               5                   10                  15      


Asp Tyr Lys Val Pro Ala Lys Lys Met Lys Val Leu Gly Asn Thr Asp 
            20                  25                  30          


Lys Ser His Ile Lys Lys Asn Leu Leu Gly Ala Leu Leu Phe Asp Ser 
        35                  40                  45              


Gly Asn Thr Ala Ala Asp Arg Arg Leu Lys Arg Thr Ala Arg Arg Arg 
    50                  55                  60                  


Tyr Thr Arg Arg Arg Asn Arg Ile Leu Tyr Leu Gln Glu Ile Phe Ala 
65                  70                  75                  80  


Glu Glu Met Ser Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Asp 
                85                  90                  95      


Ser Phe Leu Val Thr Glu Asp Lys Arg Gly Glu Arg His Pro Ile Phe 
            100                 105                 110         


Gly Asn Leu Glu Glu Glu Val Lys Tyr His Glu Asn Phe Pro Thr Ile 
        115                 120                 125             


Tyr His Leu Arg Gln Tyr Leu Ala Asp Asn Pro Glu Lys Val Asp Leu 
    130                 135                 140                 


Arg Leu Val Tyr Leu Ala Leu Ala His Ile Ile Lys Phe Arg Gly His 
145                 150                 155                 160 


Phe Leu Ile Glu Gly Lys Phe Asp Thr Arg Asn Asn Asp Val Gln Arg 
                165                 170                 175     


Leu Phe Gln Glu Phe Leu Ala Val Tyr Asp Asn Thr Phe Glu Asn Ser 
            180                 185                 190         


Ser Leu Gln Glu Gln Asn Val Gln Val Glu Glu Ile Leu Thr Asp Lys 
        195                 200                 205             


Ile Ser Lys Ser Ala Lys Lys Asp Arg Val Leu Lys Leu Phe Pro Asn 
    210                 215                 220                 


Glu Lys Ser Asn Gly Arg Phe Ala Glu Phe Leu Lys Leu Ile Val Gly 
225                 230                 235                 240 


Asn Gln Ala Asp Phe Lys Lys His Phe Glu Leu Glu Glu Lys Ala Pro 
                245                 250                 255     


Leu Gln Phe Ser Lys Asp Thr Tyr Glu Glu Glu Leu Glu Val Leu Leu 
            260                 265                 270         


Ala Gln Ile Gly Asp Asn Tyr Ala Glu Leu Phe Leu Ser Ala Lys Lys 
        275                 280                 285             


Leu Tyr Asp Ser Ile Leu Leu Ser Gly Ile Leu Thr Val Thr Asp Val 
    290                 295                 300                 


Ser Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Gln Arg Tyr Asn Glu 
305                 310                 315                 320 


His Gln Met Asp Leu Ala Gln Leu Lys Gln Phe Ile Arg Gln Lys Leu 
                325                 330                 335     


Ser Asp Lys Tyr Asn Glu Val Phe Ser Asp Val Ser Lys Asp Gly Tyr 
            340                 345                 350         


Ala Gly Tyr Ile Asp Gly Lys Thr Asn Gln Glu Ala Phe Tyr Lys Tyr 
        355                 360                 365             


Leu Lys Gly Leu Leu Asn Lys Ile Glu Gly Ser Gly Tyr Phe Leu Asp 
    370                 375                 380                 


Lys Ile Glu Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn 
385                 390                 395                 400 


Gly Ser Ile Pro His Gln Ile His Leu Gln Glu Met Arg Ala Ile Ile 
                405                 410                 415     


Arg Arg Gln Ala Glu Phe Tyr Pro Phe Leu Ala Asp Asn Gln Asp Arg 
            420                 425                 430         


Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
        435                 440                 445             


Ala Arg Gly Lys Ser Asp Phe Ala Trp Leu Ser Arg Lys Ser Ala Asp 
    450                 455                 460                 


Lys Ile Thr Pro Trp Asn Phe Asp Glu Ile Val Asp Lys Glu Ser Ser 
465                 470                 475                 480 


Ala Glu Ala Phe Ile Asn Arg Met Thr Asn Tyr Asp Leu Tyr Leu Pro 
                485                 490                 495     


Asn Gln Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Thr 
            500                 505                 510         


Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Lys Thr Glu Gln Gly Lys 
        515                 520                 525             


Thr Ala Phe Phe Asp Ala Asn Met Lys Gln Glu Ile Phe Asp Gly Val 
    530                 535                 540                 


Phe Lys Val Tyr Arg Lys Val Thr Lys Asp Lys Leu Met Asp Phe Leu 
545                 550                 555                 560 


Glu Lys Glu Phe Asp Glu Phe Arg Ile Val Asp Leu Thr Gly Leu Asp 
                565                 570                 575     


Lys Glu Asn Lys Ala Phe Asn Ala Ser Tyr Gly Thr Tyr His Asp Leu 
            580                 585                 590         


Arg Lys Ile Leu Asp Lys Asp Phe Leu Asp Asn Ser Lys Asn Glu Lys 
        595                 600                 605             


Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu 
    610                 615                 620                 


Met Ile Arg Lys Arg Leu Glu Asn Tyr Ser Asp Leu Leu Thr Lys Glu 
625                 630                 635                 640 


Gln Val Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg Leu 
                645                 650                 655     


Ser Ala Glu Leu Ile His Gly Ile Arg Asn Lys Glu Ser Arg Lys Thr 
            660                 665                 670         


Ile Leu Asp Tyr Leu Ile Asp Asp Gly Asn Ser Asn Arg Asn Phe Met 
        675                 680                 685             


Gln Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala Lys 
    690                 695                 700                 


Ala Gln Val Ile Gly Glu Thr Asp Asn Leu Asn Gln Val Val Ser Asp 
705                 710                 715                 720 


Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys 
                725                 730                 735     


Ile Val Asp Glu Leu Val Lys Ile Met Gly His Gln Pro Glu Asn Ile 
            740                 745                 750         


Val Val Glu Met Ala Arg Glu Asn Gln Phe Thr Asn Gln Gly Arg Arg 
        755                 760                 765             


Asn Ser Gln Gln Arg Leu Lys Gly Leu Thr Asp Ser Ile Lys Glu Phe 
    770                 775                 780                 


Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu His Ser Gln Leu Gln 
785                 790                 795                 800 


Asn Asp Arg Leu Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr 
                805                 810                 815     


Thr Gly Glu Glu Leu Asp Ile Asp Tyr Leu Ser Gln Tyr Asp Ile Asp 
            820                 825                 830         


His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg 
        835                 840                 845             


Val Leu Thr Ser Ser Lys Glu Asn Arg Gly Lys Ser Asp Asp Val Pro 
    850                 855                 860                 


Ser Lys Asn Val Val Arg Lys Met Lys Ser Tyr Trp Ser Lys Leu Leu 
865                 870                 875                 880 


Ser Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
                885                 890                 895     


Glu Arg Gly Gly Leu Thr Asp Asp Asp Lys Ala Gly Phe Ile Lys Arg 
            900                 905                 910         


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu 
        915                 920                 925             


Asp Glu Arg Phe His Thr Glu Thr Asp Glu Asn Asn Lys Lys Ile Arg 
    930                 935                 940                 


Gln Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg 
945                 950                 955                 960 


Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His 
                965                 970                 975     


Ala His Asp Ala Tyr Leu Asn Ala Val Ile Gly Lys Ala Leu Leu Gly 
            980                 985                 990         


Val Tyr Pro Gln Leu Glu Pro Glu  Phe Val Tyr Gly Asp  Tyr Pro His 
        995                 1000                 1005             


Phe His  Gly His Lys Glu Asn  Lys Ala Thr Ala Lys  Lys Phe Phe 
    1010                 1015                 1020             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Lys Asp Asp  Val Arg Thr 
    1025                 1030                 1035             


Asp Lys  Asn Gly Glu Ile Ile  Trp Lys Lys Asp Glu  His Ile Ser 
    1040                 1045                 1050             


Asn Ile  Lys Lys Val Leu Ser  Tyr Pro Gln Val Asn  Ile Val Lys 
    1055                 1060                 1065             


Lys Val  Glu Glu Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1070                 1075                 1080             


Pro Lys  Gly Asn Ser Asp Lys  Leu Ile Pro Arg Lys  Thr Lys Lys 
    1085                 1090                 1095             


Phe Tyr  Trp Asp Thr Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Ile 
    1100                 1105                 1110             


Val Ala  Tyr Ser Ile Leu Val  Ile Ala Asp Ile Glu  Lys Gly Lys 
    1115                 1120                 1125             


Ser Lys  Lys Leu Lys Thr Val  Lys Ala Leu Val Gly  Val Thr Ile 
    1130                 1135                 1140             


Met Glu  Lys Met Thr Phe Glu  Arg Asp Pro Val Ala  Phe Leu Glu 
    1145                 1150                 1155             


Arg Lys  Gly Tyr Arg Asn Val  Gln Glu Glu Asn Ile  Ile Lys Leu 
    1160                 1165                 1170             


Pro Lys  Tyr Ser Leu Phe Lys  Leu Glu Asn Gly Arg  Lys Arg Leu 
    1175                 1180                 1185             


Leu Ala  Ser Ala Arg Glu Leu  Gln Lys Gly Asn Glu  Ile Val Leu 
    1190                 1195                 1200             


Pro Asn  His Leu Gly Thr Leu  Leu Tyr His Ala Lys  Asn Ile His 
    1205                 1210                 1215             


Lys Val  Asp Glu Pro Lys His  Leu Asp Tyr Val Asp  Lys His Lys 
    1220                 1225                 1230             


Asp Glu  Phe Lys Glu Leu Leu  Asp Val Val Ser Asn  Phe Ser Lys 
    1235                 1240                 1245             


Lys Tyr  Thr Leu Ala Glu Gly  Asn Leu Glu Lys Ile  Lys Glu Leu 
    1250                 1255                 1260             


Tyr Ala  Gln Asn Asn Gly Glu  Asp Leu Lys Glu Leu  Ala Ser Ser 
    1265                 1270                 1275             


Phe Ile  Asn Leu Leu Thr Phe  Thr Ala Ile Gly Ala  Pro Ala Thr 
    1280                 1285                 1290             


Phe Lys  Phe Phe Asp Lys Asn  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1295                 1300                 1305             


Thr Thr  Glu Ile Leu Asn Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Lys Leu  Gly Gly Asp 
    1325                 1330                 1335             


<210> 516
<211> 1128
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NLML5

<400> 516
Met Ala Asn Ser Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Asp Lys Glu Thr Gly Lys Ile Ile His Val Asn 
            20                  25                  30          


Ser Arg Ile Phe Pro Ala Ala Thr Ala Asp Ser Asn Val Glu Arg Arg 
        35                  40                  45              


Gly Phe Arg Gln Gly Arg Arg Leu Val Arg Arg Lys Lys His Arg Lys 
    50                  55                  60                  


Val Arg Leu Ala Asp Leu Phe Leu Asp Ser Asn Leu Leu Thr Asp Phe 
65                  70                  75                  80  


Ser Lys Val Ser Leu Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly 
                85                  90                  95      


Leu Asn Glu Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Ser 
            100                 105                 110         


Ile Val Ser Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp 
        115                 120                 125             


Ser Gly Ala Asn Ser Ser Glu Tyr Gly Lys Ala Val Glu Glu Asn Arg 
    130                 135                 140                 


Lys Leu Leu Glu Asp Arg Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe 
145                 150                 155                 160 


Glu Lys Tyr Gly Lys Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly 
                165                 170                 175     


Glu Asn His Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Lys Lys 
            180                 185                 190         


Glu Ala Glu Arg Ile Leu Arg Arg Gln Gln Glu Phe Asn Ile Arg Ile 
        195                 200                 205             


Ala Asp Glu Phe Ile Glu Ala Tyr Leu Thr Ile Leu Thr Gly Lys Arg 
    210                 215                 220                 


Lys Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly 
225                 230                 235                 240 


Arg Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu 
                245                 250                 255     


Ile Gly Lys Cys Thr Phe Tyr Pro Asp Glu Tyr Arg Ala Ala Lys Ala 
            260                 265                 270         


Ser Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu 
        275                 280                 285             


Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Arg Gln 
    290                 295                 300                 


Ile Ile Glu His Ala Lys Thr Val Lys Thr Leu Gly Ala Pro Thr Leu 
305                 310                 315                 320 


Leu Lys Tyr Ile Ala Lys Leu Val Gly Cys Ser Ala Asp Asp Ile Lys 
                325                 330                 335     


Gly Tyr Arg Ile Asp Lys Ser Asp Lys Pro Glu Ile His Thr Phe Glu 
            340                 345                 350         


Ala Tyr Arg Lys Met Arg Thr Met Glu Leu Ile Lys Val Ala Asp Leu 
        355                 360                 365             


Ser Arg Glu Ser Leu Asp Ala Leu Ala His Ile Leu Thr Leu Asn Thr 
    370                 375                 380                 


Glu Arg Glu Gly Ile Glu Glu Ala Ile Arg Asp Arg Phe Thr Asn Lys 
385                 390                 395                 400 


Glu Phe Asn Gln Glu Gln Ile Asn Glu Leu Val Leu Phe Arg Lys Asn 
                405                 410                 415     


Asn Ser Ser Leu Phe Gly Lys Gly Trp His Asn Phe Ser Leu Lys Leu 
            420                 425                 430         


Met Lys Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met 
        435                 440                 445             


Thr Ile Leu Thr Arg Leu Gly Lys Gln Arg Val Lys Lys Ser Ser Asn 
    450                 455                 460                 


Arg Thr Asn Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn 
465                 470                 475                 480 


Pro Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Leu 
                485                 490                 495     


Ala Thr Lys Lys Tyr Gly Val Phe Asp Asn Ile Val Ile Glu Met Ala 
            500                 505                 510         


Arg Glu Ser Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Asn Ala Gln 
        515                 520                 525             


Lys Ala Asn Glu Asp Glu Lys Glu Ala Ala Leu Leu Lys Ala Ala His 
    530                 535                 540                 


Gln Phe Asn Gly Lys Glu Glu Leu Pro Asp Ser Ile Phe His Gly His 
545                 550                 555                 560 


Lys Glu Leu Leu Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys 
                565                 570                 575     


Cys Leu Tyr Thr Gly Lys Thr Ile Phe Ile Asn Asp Leu Ile His Asn 
            580                 585                 590         


Pro Tyr Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe 
        595                 600                 605             


Asp Asp Ser Leu Ala Asn Lys Val Leu Val Leu Ser Thr Ala Asn Gln 
    610                 615                 620                 


Glu Lys Gly Gln Arg Thr Pro Phe Gln Ser Leu Asp Ser Met Asp Gly 
625                 630                 635                 640 


Ala Trp Thr Tyr Arg Glu Phe Lys Ala Tyr Val Lys Gly Leu Lys Thr 
                645                 650                 655     


Leu Ser Asn Lys Lys Lys Asp Tyr Leu Leu Asn Glu Glu Asp Ile Asn 
            660                 665                 670         


Lys Asn Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr 
        675                 680                 685             


Arg Tyr Ser Ser Arg Val Val Leu Asn Thr Leu Gln Asp Phe Tyr Lys 
    690                 695                 700                 


Lys Arg Glu Phe Asp Thr Lys Ile Ser Val Val Arg Gly Gln Phe Thr 
705                 710                 715                 720 


Ser Gln Ile Arg Arg Lys Trp Arg Ile Glu Lys Thr Arg Glu Thr Tyr 
                725                 730                 735     


His His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu 
            740                 745                 750         


Asn Leu Trp Lys Lys Gln Asn Asn Pro Leu Ile Ser Tyr Lys Glu Asp 
        755                 760                 765             


Gln Phe Val Asp Pro Glu Thr Gly Glu Ile Leu Ser Leu Ser Asp Asp 
    770                 775                 780                 


Glu Tyr Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp 
785                 790                 795                 800 


Thr Leu Lys Ser Lys Lys Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Tyr Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Gly 
            820                 825                 830         


Thr Arg Lys Ala Arg Leu Gly Lys Asp Ser Gln Glu Glu Thr Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gln Lys Gly Tyr Glu Asp Phe 
    850                 855                 860                 


Ile Lys Lys Tyr Lys Lys Asp Lys Thr Gln Phe Leu Met Tyr His Lys 
865                 870                 875                 880 


Asp Pro Gln Thr Phe Glu Lys Val Ile Glu Glu Ile Leu Lys Thr Tyr 
                885                 890                 895     


Ser Asp Lys Glu Leu Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro 
            900                 905                 910         


Phe Glu Lys Tyr Arg Gln Glu Asn Gly Pro Val Arg Lys Tyr Ser Lys 
        915                 920                 925             


Lys Gly Asn Gly Pro Glu Ile Lys Ser Ile Lys Tyr Tyr Asp Asn Lys 
    930                 935                 940                 


Leu Gly Asn His Ile Asp Ile Thr Pro Asn Asn Ser His His Gln Val 
945                 950                 955                 960 


Val Leu Gln Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Pro 
                965                 970                 975     


Lys Ser Gly Lys Tyr Glu Leu Met Gly Leu Lys Tyr Ser Asp Leu Arg 
            980                 985                 990         


Phe Glu Lys Val Ser Gly Asp Tyr  Gly Ile Ser Val Lys  Lys Tyr Asn 
        995                 1000                 1005             


Glu Ile  Lys Ser Lys Glu Gly  Val Asp Glu Asn Ser  Glu Phe Lys 
    1010                 1015                 1020             


Phe Thr  Leu Tyr Lys Asn Asp  Leu Ile Leu Ile Lys  Asp Thr Glu 
    1025                 1030                 1035             


Ser Gly  Glu Gln Glu Leu Phe  Arg Phe Leu Ser Arg  Thr Met Pro 
    1040                 1045                 1050             


Asn Gln  Lys His Tyr Val Glu  Leu Lys Pro Tyr Asp  Lys Ser Lys 
    1055                 1060                 1065             


Phe Glu  Gly His Gln Lys Leu  Met Asp Ile Phe Gly  Glu Val Ala 
    1070                 1075                 1080             


Lys Gly  Gly Gln Cys Leu Lys  Gly Leu Asn Lys Ser  Asn Ile Ser 
    1085                 1090                 1095             


Ile Tyr  Lys Val Lys Thr Asp  Val Leu Gly Asn Lys  Tyr Phe Ile 
    1100                 1105                 1110             


Lys Lys  Glu Gly Asp Gln Pro  Gln Leu Asn Phe Lys  Lys Lys Ile 
    1115                 1120                 1125             


<210> 517
<211> 1128
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NLML5

<400> 517
Met Ala Asn Ser Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Asp Lys Glu Thr Gly Lys Ile Ile His Val Asn 
            20                  25                  30          


Ser Arg Ile Phe Pro Ala Ala Thr Ala Asp Ser Asn Val Glu Arg Arg 
        35                  40                  45              


Gly Phe Arg Gln Gly Arg Arg Leu Val Arg Arg Lys Lys His Arg Lys 
    50                  55                  60                  


Val Arg Leu Ala Asp Leu Phe Leu Asp Ser Asn Leu Leu Thr Asp Phe 
65                  70                  75                  80  


Ser Lys Val Ser Leu Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly 
                85                  90                  95      


Leu Asn Glu Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Ser 
            100                 105                 110         


Ile Val Ser Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp 
        115                 120                 125             


Ser Gly Ala Asn Ser Ser Glu Tyr Gly Lys Ala Val Glu Glu Asn Arg 
    130                 135                 140                 


Lys Leu Leu Glu Asp Arg Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe 
145                 150                 155                 160 


Glu Lys Tyr Gly Lys Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly 
                165                 170                 175     


Glu Asn His Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Lys Lys 
            180                 185                 190         


Glu Ala Glu Arg Ile Leu Arg Arg Gln Gln Glu Phe Asn Ile Arg Ile 
        195                 200                 205             


Ala Asp Glu Phe Ile Glu Ala Tyr Leu Thr Ile Leu Thr Gly Lys Arg 
    210                 215                 220                 


Lys Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly 
225                 230                 235                 240 


Arg Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu 
                245                 250                 255     


Ile Gly Lys Cys Thr Phe Tyr Pro Asp Glu Tyr Arg Ala Ala Lys Ala 
            260                 265                 270         


Ser Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu 
        275                 280                 285             


Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Arg Gln 
    290                 295                 300                 


Ile Ile Glu His Ala Lys Thr Val Lys Thr Leu Gly Ala Pro Thr Leu 
305                 310                 315                 320 


Leu Lys Tyr Ile Ala Lys Leu Val Gly Cys Ser Ala Asp Asp Ile Lys 
                325                 330                 335     


Gly Tyr Arg Ile Asp Lys Ser Asp Lys Pro Glu Ile His Thr Phe Glu 
            340                 345                 350         


Ala Tyr Arg Lys Met Arg Thr Met Glu Leu Ile Lys Val Ala Asp Leu 
        355                 360                 365             


Ser Arg Glu Ser Leu Asp Ala Leu Ala His Ile Leu Thr Leu Asn Thr 
    370                 375                 380                 


Glu Arg Glu Gly Ile Glu Glu Ala Ile Arg Asp Arg Phe Thr Asn Lys 
385                 390                 395                 400 


Glu Phe Asn Gln Glu Gln Ile Asn Glu Leu Val Leu Phe Arg Lys Asn 
                405                 410                 415     


Asn Ser Ser Leu Phe Gly Lys Gly Trp His Asn Phe Ser Leu Lys Leu 
            420                 425                 430         


Met Lys Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met 
        435                 440                 445             


Thr Ile Leu Thr Arg Leu Gly Lys Gln Arg Val Lys Lys Ser Ser Asn 
    450                 455                 460                 


Arg Thr Asn Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn 
465                 470                 475                 480 


Pro Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Leu 
                485                 490                 495     


Ala Thr Lys Lys Tyr Gly Val Phe Asp Asn Ile Val Ile Glu Met Ala 
            500                 505                 510         


Arg Glu Ser Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Asn Ala Gln 
        515                 520                 525             


Lys Ala Asn Glu Asp Glu Lys Glu Ala Ala Leu Leu Lys Ala Ala His 
    530                 535                 540                 


Gln Phe Asn Gly Lys Glu Glu Leu Pro Asp Ser Ile Phe His Gly His 
545                 550                 555                 560 


Lys Glu Leu Leu Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys 
                565                 570                 575     


Cys Leu Tyr Thr Gly Lys Thr Ile Phe Ile Asn Asp Leu Ile His Asn 
            580                 585                 590         


Pro Tyr Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe 
        595                 600                 605             


Asp Asp Ser Leu Ala Asn Lys Val Leu Val Leu Ser Thr Ala Asn Gln 
    610                 615                 620                 


Glu Lys Gly Gln Arg Thr Pro Phe Gln Ser Leu Asp Ser Met Asp Gly 
625                 630                 635                 640 


Ala Trp Thr Tyr Arg Glu Phe Lys Ala Tyr Val Lys Gly Leu Lys Thr 
                645                 650                 655     


Leu Ser Asn Lys Lys Lys Asp Tyr Leu Leu Asn Glu Glu Asp Ile Asn 
            660                 665                 670         


Lys Asn Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr 
        675                 680                 685             


Arg Tyr Ser Ser Arg Val Val Leu Asn Thr Leu Gln Asp Phe Tyr Lys 
    690                 695                 700                 


Lys Arg Glu Phe Asp Thr Lys Ile Ser Val Val Arg Gly Gln Phe Thr 
705                 710                 715                 720 


Ser Gln Ile Arg Arg Lys Trp Arg Ile Glu Lys Thr Arg Glu Thr Tyr 
                725                 730                 735     


His His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu 
            740                 745                 750         


Asn Leu Trp Lys Lys Gln Asn Asn Pro Leu Ile Ser Tyr Lys Glu Asp 
        755                 760                 765             


Gln Phe Val Asp Pro Glu Thr Gly Glu Ile Leu Ser Leu Ser Asp Asp 
    770                 775                 780                 


Glu Tyr Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp 
785                 790                 795                 800 


Thr Leu Lys Ser Lys Lys Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Tyr Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Gly 
            820                 825                 830         


Thr Arg Lys Ala Arg Leu Gly Lys Asp Ser Gln Glu Glu Thr Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gln Lys Gly Tyr Glu Asp Phe 
    850                 855                 860                 


Ile Lys Lys Tyr Lys Lys Asp Lys Thr Gln Phe Leu Met Tyr His Lys 
865                 870                 875                 880 


Asp Pro Gln Thr Phe Glu Lys Val Ile Glu Glu Ile Leu Lys Thr Tyr 
                885                 890                 895     


Ser Asp Lys Glu Leu Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro 
            900                 905                 910         


Phe Glu Lys Tyr Arg Gln Glu Asn Gly Pro Val Arg Lys Tyr Ser Lys 
        915                 920                 925             


Lys Gly Asn Gly Pro Glu Ile Lys Ser Ile Lys Tyr Tyr Asp Asn Lys 
    930                 935                 940                 


Leu Gly Asn His Ile Asp Ile Thr Pro Asn Asn Ser His His Gln Val 
945                 950                 955                 960 


Val Leu Gln Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Pro 
                965                 970                 975     


Lys Ser Gly Lys Tyr Glu Leu Met Gly Leu Lys Tyr Ser Asp Leu Arg 
            980                 985                 990         


Phe Glu Lys Val Ser Gly Asp Tyr  Gly Ile Ser Val Lys  Lys Tyr Asn 
        995                 1000                 1005             


Glu Ile  Lys Ser Lys Glu Gly  Val Asp Glu Asn Ser  Glu Phe Lys 
    1010                 1015                 1020             


Phe Thr  Leu Tyr Lys Asn Asp  Leu Ile Leu Ile Lys  Asp Thr Glu 
    1025                 1030                 1035             


Ser Gly  Glu Gln Glu Leu Phe  Arg Phe Leu Ser Arg  Thr Met Pro 
    1040                 1045                 1050             


Asn Gln  Lys His Tyr Val Glu  Leu Lys Pro Tyr Asp  Lys Ser Lys 
    1055                 1060                 1065             


Phe Glu  Gly His Gln Lys Leu  Met Asp Ile Phe Gly  Glu Val Ala 
    1070                 1075                 1080             


Lys Gly  Gly Gln Cys Leu Lys  Gly Leu Asn Lys Ser  Asn Ile Ser 
    1085                 1090                 1095             


Ile Tyr  Lys Val Lys Thr Asp  Val Leu Gly Asn Lys  Tyr Phe Ile 
    1100                 1105                 1110             


Lys Lys  Glu Gly Asp Gln Pro  Gln Leu Asn Phe Lys  Lys Lys Ile 
    1115                 1120                 1125             


<210> 518
<211> 1125
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NLML8

<400> 518
Met Thr Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Asn Ala Lys Thr Gly Asn Val Glu His Ala Ser 
            20                  25                  30          


Ser Arg Ile Phe Pro Ala Ala Asn Ala Asp Asn Asn Val Glu Arg Arg 
        35                  40                  45              


Ser Ala Arg Gly Gly Arg Arg Leu Ile Arg Arg Lys Lys His Arg Leu 
    50                  55                  60                  


Lys Arg Val Glu Asp Leu Phe Glu Lys Tyr Asn Ile Asp Thr Asp Phe 
65                  70                  75                  80  


Ser Asn Leu Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu Asn 
                85                  90                  95      


Glu Gln Leu Ser Asn Glu Glu Leu Phe Ala Ile Leu Lys Asn Ile Ala 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Val 
        115                 120                 125             


Gly Ser Ser Asp Tyr Ala Lys Ala Ile Asp Glu Asn Arg Lys Leu Leu 
    130                 135                 140                 


Lys Lys Gln Thr Pro Gly Glu Ile Gln Leu Lys Arg Leu Glu Lys Tyr 
145                 150                 155                 160 


Gly Gln Leu Arg Gly Asn Phe Thr Ile Gln Asp Glu Asn Gly Glu Tyr 
                165                 170                 175     


His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Val Lys Glu Ala 
            180                 185                 190         


Arg Arg Ile Leu Glu Thr Gln Ser Tyr Tyr Asn Lys Phe Ile Thr Glu 
        195                 200                 205             


Ser Phe Val Glu Asp Tyr Ile Lys Ile Leu Gln Gly Lys Arg Lys Tyr 
    210                 215                 220                 


Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile Tyr 
225                 230                 235                 240 


Arg Thr Asp Gly Glu Thr Leu Asp Asn Leu Phe Gly Ile Leu Ile Gly 
                245                 250                 255     


Lys Cys Gly Phe Tyr Pro Glu Glu Tyr Arg Ala Ala Lys Ala Ser Tyr 
            260                 265                 270         


Thr Ala Gln Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Thr Val 
        275                 280                 285             


Pro Thr Glu Thr Lys Lys Leu Ser Thr Glu Gln Lys Tyr Gln Leu Val 
    290                 295                 300                 


Asp Phe Ala Lys Thr Ala Ser Thr Leu Glu Ala Ala Lys Leu Leu Lys 
305                 310                 315                 320 


Glu Ile Ala Lys Leu Val Gly Cys Gln Val Glu Glu Ile Lys Gly Tyr 
                325                 330                 335     


Arg Leu Asp Asn Lys Asp Lys Pro Asp Leu His Thr Phe Glu Pro Phe 
            340                 345                 350         


Arg Lys Leu Lys Ser Asn Leu Thr Thr Ile Ala Val Glu Asn Leu Ser 
        355                 360                 365             


Ile Thr Thr Leu Asp Thr Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Glu Ala Ile Gln Lys Glu Leu Pro Asn Ile Phe 
385                 390                 395                 400 


Ser Asp Glu Gln Ile Thr Gly Ile Ile Ala Val Arg Lys Lys Asn Ser 
                405                 410                 415     


Gln Ile Phe Gly Lys Gly Trp His Ser Phe Ser Ile Lys Leu Met Lys 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Ile Arg Leu Lys Lys Val Lys Thr Asn Ser Lys Ile Thr Asn Arg 
    450                 455                 460                 


Thr Lys Tyr Ile Asn Glu Gln Glu Val Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ser Lys Ser Ile Arg Gln Thr Val Lys Ile Ile Asn Ala Ala 
                485                 490                 495     


Ile Lys Lys Tyr Gly Ala Phe Asp Gln Ile Val Ile Glu Met Pro Arg 
            500                 505                 510         


Glu Ser Asn Glu Glu Asp Glu Arg Lys Phe Ile Ala Asp Leu Gln Lys 
        515                 520                 525             


Ser Asn Ala Lys Glu Lys Asp Asp Ala Met Lys Gln Ala Ala Leu Leu 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Gly Val Phe His Gly His Lys 
545                 550                 555                 560 


Glu Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Ser Gly Lys His Ile Asp Ile His Asp Leu Ile His Asn Gln 
            580                 585                 590         


His Met Phe Glu Ile Asp His Val Leu Pro Leu Ser Leu Ser Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ser Trp Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Phe Gln Ala Leu Pro Gln Met Ala Ser Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Arg Asp Tyr Ile Ser Lys Gln Lys Gly Ile 
                645                 650                 655     


Ser Lys Lys Lys Arg Asp Tyr Leu Leu Thr Glu Gln Asp Ile Asn Lys 
            660                 665                 670         


Val Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Val Ser Arg Val Val Leu Asn Thr Leu Gln Asp Ala Leu Lys Val 
    690                 695                 700                 


Met Asn Lys Glu Thr Lys Ile Ser Val Ile Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg Gln Trp Arg Ile Asp Lys Ser Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg 
            740                 745                 750         


Leu Trp Lys Lys Gln Asn Asn Pro Met Phe Ala Glu Asp Lys His Gly 
        755                 760                 765             


Gln Lys Ile Asn Leu Asp Thr Gly Glu Val Leu Ser Asp Asp Ala Tyr 
    770                 775                 780                 


Lys Glu Leu Val Tyr Gln Ala Pro Tyr Gln Gly Phe Val Asn Thr Ile 
785                 790                 795                 800 


Ser Ser Lys Ser Phe Glu Asp Glu Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Val Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Gln Ala Gln Leu Gly Lys Asp Lys Lys Glu Glu Thr Tyr Val Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ser Gln Ala Gly Tyr Asp Ala Phe Arg Lys 
    850                 855                 860                 


Lys Tyr Asp Lys Asp Lys Ala Val Phe Leu Met Tyr Gln Lys Asp Pro 
865                 870                 875                 880 


Glu Thr Trp Glu Lys Val Ile Glu Val Ile Leu Arg Asp Tyr Lys Glu 
                885                 890                 895     


Leu Asp Asp Lys Gly Lys Glu Ile Gly Asn Pro Phe Glu Arg Tyr Lys 
            900                 905                 910         


Val Lys His Gly Phe Val Arg Lys Tyr Ser Arg Lys Asn Lys Gly Thr 
        915                 920                 925             


Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly Asn His Ile 
    930                 935                 940                 


Asp Ile Thr Pro Asn Asn Ser Lys His Ser Val Val Leu Gln Ser Ile 
945                 950                 955                 960 


Asn Pro Trp Arg Ala Asp Leu Tyr Phe Asn Pro Glu Thr Thr Lys Tyr 
                965                 970                 975     


Glu Leu Met Gly Leu Lys Tyr Ala Asp Leu Ser Phe Glu Lys Gly Thr 
            980                 985                 990         


Gly Lys Tyr Ser Ile Ser Arg Glu  Lys Tyr Asp Glu Ile  Lys Glu Arg 
        995                 1000                 1005             


Glu Gly  Ile Ser Ser Lys Ser  Glu Phe Lys Phe Thr  Leu Tyr Lys 
    1010                 1015                 1020             


Asn Asp  Leu Ile Leu Val Lys  Asp Ile Gly Asn His  Lys Glu Leu 
    1025                 1030                 1035             


Ile Ala  Arg Phe Asn Ser Lys  Asn Asp Thr Ser Lys  His Tyr Val 
    1040                 1045                 1050             


Glu Leu  Lys Pro Trp Asn Lys  Ala Lys Phe Asp Ser  Glu Glu Glu 
    1055                 1060                 1065             


Leu Ile  Pro Ala Phe Gly Lys  Val Ala Lys Ser Gly  Gln Phe Ile 
    1070                 1075                 1080             


Lys Gly  Leu Asn Lys Pro Asp  Leu Ser Ile Tyr Lys  Val Lys Thr 
    1085                 1090                 1095             


Asp Ile  Leu Gly His Lys Tyr  Tyr Ile Lys Lys Glu  Gly Asp Lys 
    1100                 1105                 1110             


Pro Lys  Leu Asn Phe Glu Asn  Lys Ile Lys Asn Lys  
    1115                 1120                 1125 


<210> 519
<211> 1125
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NLML8

<400> 519
Met Thr Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Asn Ala Lys Thr Gly Asn Val Glu His Ala Ser 
            20                  25                  30          


Ser Arg Ile Phe Pro Ala Ala Asn Ala Asp Asn Asn Val Glu Arg Arg 
        35                  40                  45              


Ser Ala Arg Gly Gly Arg Arg Leu Ile Arg Arg Lys Lys His Arg Leu 
    50                  55                  60                  


Lys Arg Val Glu Asp Leu Phe Glu Lys Tyr Asn Ile Asp Thr Asp Phe 
65                  70                  75                  80  


Ser Asn Leu Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu Asn 
                85                  90                  95      


Glu Gln Leu Ser Asn Glu Glu Leu Phe Ala Ile Leu Lys Asn Ile Ala 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Val 
        115                 120                 125             


Gly Ser Ser Asp Tyr Ala Lys Ala Ile Asp Glu Asn Arg Lys Leu Leu 
    130                 135                 140                 


Lys Lys Gln Thr Pro Gly Glu Ile Gln Leu Lys Arg Leu Glu Lys Tyr 
145                 150                 155                 160 


Gly Gln Leu Arg Gly Asn Phe Thr Ile Gln Asp Glu Asn Gly Glu Tyr 
                165                 170                 175     


His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Val Lys Glu Ala 
            180                 185                 190         


Arg Arg Ile Leu Glu Thr Gln Ser Tyr Tyr Asn Lys Phe Ile Thr Glu 
        195                 200                 205             


Ser Phe Val Glu Asp Tyr Ile Lys Ile Leu Gln Gly Lys Arg Lys Tyr 
    210                 215                 220                 


Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile Tyr 
225                 230                 235                 240 


Arg Thr Asp Gly Glu Thr Leu Asp Asn Leu Phe Gly Ile Leu Ile Gly 
                245                 250                 255     


Lys Cys Gly Phe Tyr Pro Glu Glu Tyr Arg Ala Ala Lys Ala Ser Tyr 
            260                 265                 270         


Thr Ala Gln Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Thr Val 
        275                 280                 285             


Pro Thr Glu Thr Lys Lys Leu Ser Thr Glu Gln Lys Tyr Gln Leu Val 
    290                 295                 300                 


Asp Phe Ala Lys Thr Ala Ser Thr Leu Glu Ala Ala Lys Leu Leu Lys 
305                 310                 315                 320 


Glu Ile Ala Lys Leu Val Gly Cys Gln Val Glu Glu Ile Lys Gly Tyr 
                325                 330                 335     


Arg Leu Asp Asn Lys Asp Lys Pro Asp Leu His Thr Phe Glu Pro Phe 
            340                 345                 350         


Arg Lys Leu Lys Ser Asn Leu Thr Thr Ile Ala Val Glu Asn Leu Ser 
        355                 360                 365             


Ile Thr Thr Leu Asp Thr Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Glu Ala Ile Gln Lys Glu Leu Pro Asn Ile Phe 
385                 390                 395                 400 


Ser Asp Glu Gln Ile Thr Gly Ile Ile Ala Val Arg Lys Lys Asn Ser 
                405                 410                 415     


Gln Ile Phe Gly Lys Gly Trp His Ser Phe Ser Ile Lys Leu Met Lys 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Ile Arg Leu Lys Lys Val Lys Thr Asn Ser Lys Ile Thr Asn Arg 
    450                 455                 460                 


Thr Lys Tyr Ile Asn Glu Gln Glu Val Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ser Lys Ser Ile Arg Gln Thr Val Lys Ile Ile Asn Ala Ala 
                485                 490                 495     


Ile Lys Lys Tyr Gly Ala Phe Asp Gln Ile Val Ile Glu Met Pro Arg 
            500                 505                 510         


Glu Ser Asn Glu Glu Asp Glu Arg Lys Phe Ile Ala Asp Leu Gln Lys 
        515                 520                 525             


Ser Asn Ala Lys Glu Lys Asp Asp Ala Met Lys Gln Ala Ala Leu Leu 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Gly Val Phe His Gly His Lys 
545                 550                 555                 560 


Glu Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Ser Gly Lys His Ile Asp Ile His Asp Leu Ile His Asn Gln 
            580                 585                 590         


His Met Phe Glu Ile Asp His Val Leu Pro Leu Ser Leu Ser Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ser Trp Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Phe Gln Ala Leu Pro Gln Met Ala Ser Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Arg Asp Tyr Ile Ser Lys Gln Lys Gly Ile 
                645                 650                 655     


Ser Lys Lys Lys Arg Asp Tyr Leu Leu Thr Glu Gln Asp Ile Asn Lys 
            660                 665                 670         


Val Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Val Ser Arg Val Val Leu Asn Thr Leu Gln Asp Ala Leu Lys Val 
    690                 695                 700                 


Met Asn Lys Glu Thr Lys Ile Ser Val Ile Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg Gln Trp Arg Ile Asp Lys Ser Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg 
            740                 745                 750         


Leu Trp Lys Lys Gln Asn Asn Pro Met Phe Ala Glu Asp Lys His Gly 
        755                 760                 765             


Gln Lys Ile Asn Leu Asp Thr Gly Glu Val Leu Ser Asp Asp Ala Tyr 
    770                 775                 780                 


Lys Glu Leu Val Tyr Gln Ala Pro Tyr Gln Gly Phe Val Asn Thr Ile 
785                 790                 795                 800 


Ser Ser Lys Ser Phe Glu Asp Glu Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Val Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Gln Ala Gln Leu Gly Lys Asp Lys Lys Glu Glu Thr Tyr Val Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ser Gln Ala Gly Tyr Asp Ala Phe Arg Lys 
    850                 855                 860                 


Lys Tyr Asp Lys Asp Lys Ala Val Phe Leu Met Tyr Gln Lys Asp Pro 
865                 870                 875                 880 


Glu Thr Trp Glu Lys Val Ile Glu Val Ile Leu Arg Asp Tyr Lys Glu 
                885                 890                 895     


Leu Asp Asp Lys Gly Lys Glu Ile Gly Asn Pro Phe Glu Arg Tyr Lys 
            900                 905                 910         


Val Lys His Gly Phe Val Arg Lys Tyr Ser Arg Lys Asn Lys Gly Thr 
        915                 920                 925             


Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly Asn His Ile 
    930                 935                 940                 


Asp Ile Thr Pro Asn Asn Ser Lys His Ser Val Val Leu Gln Ser Ile 
945                 950                 955                 960 


Asn Pro Trp Arg Ala Asp Leu Tyr Phe Asn Pro Glu Thr Thr Lys Tyr 
                965                 970                 975     


Glu Leu Met Gly Leu Lys Tyr Ala Asp Leu Ser Phe Glu Lys Gly Thr 
            980                 985                 990         


Gly Lys Tyr Ser Ile Ser Arg Glu  Lys Tyr Asp Glu Ile  Lys Glu Arg 
        995                 1000                 1005             


Glu Gly  Ile Ser Ser Lys Ser  Glu Phe Lys Phe Thr  Leu Tyr Lys 
    1010                 1015                 1020             


Asn Asp  Leu Ile Leu Val Lys  Asp Ile Gly Asn His  Lys Glu Leu 
    1025                 1030                 1035             


Ile Ala  Arg Phe Asn Ser Lys  Asn Asp Thr Ser Lys  His Tyr Val 
    1040                 1045                 1050             


Glu Leu  Lys Pro Trp Asn Lys  Ala Lys Phe Asp Ser  Glu Glu Glu 
    1055                 1060                 1065             


Leu Ile  Pro Ala Phe Gly Lys  Val Ala Lys Ser Gly  Gln Phe Ile 
    1070                 1075                 1080             


Lys Gly  Leu Asn Lys Pro Asp  Leu Ser Ile Tyr Lys  Val Lys Thr 
    1085                 1090                 1095             


Asp Ile  Leu Gly His Lys Tyr  Tyr Ile Lys Lys Glu  Gly Asp Lys 
    1100                 1105                 1110             


Pro Lys  Leu Asn Phe Glu Asn  Lys Ile Lys Asn Lys  
    1115                 1120                 1125 


<210> 520
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NLML9

<400> 520
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Ser Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Thr His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 521
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NLML9

<400> 521
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Ser Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Thr His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 522
<211> 1355
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NMT4863

<400> 522
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Thr 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Leu Asp Gln Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr His Ser Asp Glu Ala Val Thr Pro Trp Asn Phe Asp Gln 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Gln Ala Phe Ile Glu His Met Thr 
                485                 490                 495     


Asn Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Thr Glu Ile Gly Glu Ala Lys Phe Phe Asp Ala Asn Leu Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Leu Phe Lys His Glu Arg Lys Val Thr Lys 
545                 550                 555                 560 


Lys Lys Leu Arg Thr Phe Leu Asp Lys Asn Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Ile Gln Gly Leu Asp Lys Glu Thr Glu Thr Phe Asn Ala Ser 
            580                 585                 590         


Tyr Ala Thr Tyr Gln Asp Leu Leu Lys Val Ile Lys Asp Lys Val Phe 
        595                 600                 605             


Met Asp Asn Pro Glu Asn Ala Glu Ile Leu Glu Asn Ile Val Leu Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Lys 
625                 630                 635                 640 


Tyr Ala Asp Val Phe Asp Lys Lys Val Ile Asp Gln Leu Ala Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Gln Ser Cys Lys Thr Ile Met Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Ala Gln Ser Asn Arg Asn Leu Met Gln Leu Ile Thr Asp Asp Asn Leu 
    690                 695                 700                 


Thr Phe Lys Asp Asp Ile Val Lys Ala Gln Tyr Val Asp Asn Ser Asp 
705                 710                 715                 720 


Asp Leu His Gln Val Val Gln Ser Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Lys Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Lys Gly Arg Arg Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Leu Lys Glu Ala Ile Lys Ser Leu Asp Arg Asp Leu Asn His Lys Ile 
785                 790                 795                 800 


Leu Lys Glu His Pro Thr Asp Asn Gln Ala Leu Gln Asn Asn Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ser 
            820                 825                 830         


Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Ile Asp His Val Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Ser Lys Ala Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val 
865                 870                 875                 880 


Val Asn Arg Met Arg Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu 
            900                 905                 910         


Asp Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu 
    930                 935                 940                 


Phe Asp Asp Asn Asn Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Val Lys Ala Leu Leu  Val Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu 
    1010                 1015                 1020             


Arg Lys  Thr Ala Thr Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met 
    1025                 1030                 1035             


Asn Met  Phe Lys Ser Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val 
    1040                 1045                 1050             


Glu Arg  Pro Met Ile Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala 
    1055                 1060                 1065             


Trp Asp  Lys Thr Lys His Ile  Thr Thr Val Lys Lys  Val Leu Ser 
    1070                 1075                 1080             


Tyr Pro  Gln Val Asn Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile 
    1085                 1090                 1095             


Gly Gln  Asn Gly Gly Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu 
    1100                 1105                 1110             


Glu Val  Ile Pro Ser Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn 
    1115                 1120                 1125             


Pro Glu  Lys Tyr Gly Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro 
    1130                 1135                 1140             


Ile Leu  Leu Ile Val Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val 
    1145                 1150                 1155             


Met Asp  Lys Lys Arg Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys 
    1160                 1165                 1170             


Asp Lys  Gly Tyr Gln Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu 
    1175                 1180                 1185             


Pro Lys  Tyr Thr Leu Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu 
    1190                 1195                 1200             


Trp Ala  Ser Ser Lys Glu Val  His Lys Gly Asn Gln  Leu Val Val 
    1205                 1210                 1215             


Ser Lys  Lys Ser Gln Asp Leu  Leu Tyr His Ala His  His Leu Asp 
    1220                 1225                 1230             


Asn Asp  Tyr Ser Asn Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe 
    1235                 1240                 1245             


Asp Ile  Leu Phe Asn Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys 
    1250                 1255                 1260             


Leu Gly  Lys Glu His Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys 
    1265                 1270                 1275             


Glu Arg  Asp Phe Ala Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile 
    1280                 1285                 1290             


Lys Leu  Leu Gly Phe Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser 
    1295                 1300                 1305             


Phe Leu  Gly Ile Lys Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys 
    1310                 1315                 1320             


Asp Tyr  Leu Leu Pro Cys Met  Glu Ala Thr Leu Ile  His Gln Ser 
    1325                 1330                 1335             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1340                 1345                 1350             


Gly Asp  
    1355 


<210> 523
<211> 1355
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NMT4863

<400> 523
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Thr 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Leu Asp Gln Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr His Ser Asp Glu Ala Val Thr Pro Trp Asn Phe Asp Gln 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Gln Ala Phe Ile Glu His Met Thr 
                485                 490                 495     


Asn Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Thr Glu Ile Gly Glu Ala Lys Phe Phe Asp Ala Asn Leu Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Leu Phe Lys His Glu Arg Lys Val Thr Lys 
545                 550                 555                 560 


Lys Lys Leu Arg Thr Phe Leu Asp Lys Asn Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Ile Gln Gly Leu Asp Lys Glu Thr Glu Thr Phe Asn Ala Ser 
            580                 585                 590         


Tyr Ala Thr Tyr Gln Asp Leu Leu Lys Val Ile Lys Asp Lys Val Phe 
        595                 600                 605             


Met Asp Asn Pro Glu Asn Ala Glu Ile Leu Glu Asn Ile Val Leu Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Lys 
625                 630                 635                 640 


Tyr Ala Asp Val Phe Asp Lys Lys Val Ile Asp Gln Leu Ala Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Gln Ser Cys Lys Thr Ile Met Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Ala Gln Ser Asn Arg Asn Leu Met Gln Leu Ile Thr Asp Asp Asn Leu 
    690                 695                 700                 


Thr Phe Lys Asp Asp Ile Val Lys Ala Gln Tyr Val Asp Asn Ser Asp 
705                 710                 715                 720 


Asp Leu His Gln Val Val Gln Ser Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Lys Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Lys Gly Arg Arg Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Leu Lys Glu Ala Ile Lys Ser Leu Asp Arg Asp Leu Asn His Lys Ile 
785                 790                 795                 800 


Leu Lys Glu His Pro Thr Asp Asn Gln Ala Leu Gln Asn Asn Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ser 
            820                 825                 830         


Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Ile Asp His Val Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Ser Lys Ala Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val 
865                 870                 875                 880 


Val Asn Arg Met Arg Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu 
            900                 905                 910         


Asp Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu 
    930                 935                 940                 


Phe Asp Asp Asn Asn Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Val Lys Ala Leu Leu  Val Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu 
    1010                 1015                 1020             


Arg Lys  Thr Ala Thr Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met 
    1025                 1030                 1035             


Asn Met  Phe Lys Ser Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val 
    1040                 1045                 1050             


Glu Arg  Pro Met Ile Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala 
    1055                 1060                 1065             


Trp Asp  Lys Thr Lys His Ile  Thr Thr Val Lys Lys  Val Leu Ser 
    1070                 1075                 1080             


Tyr Pro  Gln Val Asn Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile 
    1085                 1090                 1095             


Gly Gln  Asn Gly Gly Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu 
    1100                 1105                 1110             


Glu Val  Ile Pro Ser Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn 
    1115                 1120                 1125             


Pro Glu  Lys Tyr Gly Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro 
    1130                 1135                 1140             


Ile Leu  Leu Ile Val Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val 
    1145                 1150                 1155             


Met Asp  Lys Lys Arg Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys 
    1160                 1165                 1170             


Asp Lys  Gly Tyr Gln Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu 
    1175                 1180                 1185             


Pro Lys  Tyr Thr Leu Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu 
    1190                 1195                 1200             


Trp Ala  Ser Ser Lys Glu Val  His Lys Gly Asn Gln  Leu Val Val 
    1205                 1210                 1215             


Ser Lys  Lys Ser Gln Asp Leu  Leu Tyr His Ala His  His Leu Asp 
    1220                 1225                 1230             


Asn Asp  Tyr Ser Asn Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe 
    1235                 1240                 1245             


Asp Ile  Leu Phe Asn Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys 
    1250                 1255                 1260             


Leu Gly  Lys Glu His Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys 
    1265                 1270                 1275             


Glu Arg  Asp Phe Ala Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile 
    1280                 1285                 1290             


Lys Leu  Leu Gly Phe Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser 
    1295                 1300                 1305             


Phe Leu  Gly Ile Lys Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys 
    1310                 1315                 1320             


Asp Tyr  Leu Leu Pro Cys Met  Glu Ala Thr Leu Ile  His Gln Ser 
    1325                 1330                 1335             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1340                 1345                 1350             


Gly Asp  
    1355 


<210> 524
<211> 1345
<212> PRT
<213> Streptococcus mutans

<400> 524
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Lys His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 525
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NV1996

<400> 525
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 526
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NVAB

<400> 526
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 527
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NVAB

<400> 527
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 528
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans R221

<400> 528
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 529
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans R221

<400> 529
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 530
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans S1B

<400> 530
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser Tyr Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Arg Asn 
225                 230                 235                 240 


Leu Val Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Ala 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 531
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans S1B

<400> 531
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser Tyr Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Arg Asn 
225                 230                 235                 240 


Leu Val Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Ala 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 532
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans SF1

<400> 532
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 533
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans SF14

<400> 533
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asn Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Ile Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 534
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans SF14

<400> 534
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asn Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Ile Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 535
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans SM1

<400> 535
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Lys Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Leu Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Leu Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Ile Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 536
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans SM1

<400> 536
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Lys Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Leu Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Leu Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Ile Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 537
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans SM4

<400> 537
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Asp Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 538
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans SM4

<400> 538
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Asp Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 539
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans SM6

<400> 539
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Gly Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 540
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans SM6

<400> 540
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Gly Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 541
<211> 1134
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans ST1

<400> 541
Met Ala Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Asp Lys Glu Thr Gly Lys Ile Ile His Val Asn 
            20                  25                  30          


Ser Arg Ile Phe Pro Ala Ala Thr Ala Asp Ser Asn Val Glu Arg Arg 
        35                  40                  45              


Gly Phe Arg Gln Gly Arg Arg Leu Val Arg Arg Lys Lys His Arg Lys 
    50                  55                  60                  


Val Arg Leu Ala Asp Leu Phe Leu Asp Ser Asn Leu Leu Thr Asp Phe 
65                  70                  75                  80  


Ser Lys Val Ser Leu Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly 
                85                  90                  95      


Leu Asn Glu Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Ser 
            100                 105                 110         


Ile Val Ser Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp 
        115                 120                 125             


Ser Gly Ala Asn Ser Ser Glu Tyr Gly Lys Ala Val Glu Glu Asn Arg 
    130                 135                 140                 


Lys Leu Leu Glu Asp Arg Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe 
145                 150                 155                 160 


Glu Lys Tyr Gly Lys Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly 
                165                 170                 175     


Glu Asn His Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Lys Lys 
            180                 185                 190         


Glu Ala Glu Arg Ile Leu Arg Arg Gln Gln Glu Phe Asn Met Arg Ile 
        195                 200                 205             


Ala Asp Glu Phe Ile Glu Ala Tyr Leu Thr Ile Leu Thr Gly Lys Arg 
    210                 215                 220                 


Lys Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly 
225                 230                 235                 240 


Arg Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu 
                245                 250                 255     


Ile Gly Lys Cys Thr Phe Tyr Pro Asp Glu Tyr Arg Ala Ala Lys Ala 
            260                 265                 270         


Ser Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu 
        275                 280                 285             


Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Arg Gln 
    290                 295                 300                 


Ile Ile Glu His Ala Lys Thr Val Lys Thr Leu Gly Ala Pro Thr Leu 
305                 310                 315                 320 


Leu Lys Tyr Ile Val Lys Leu Val Gly Cys Ser Ala Asp Asp Ile Lys 
                325                 330                 335     


Gly Tyr Arg Ile Asp Lys Ser Asp Lys Pro Glu Ile His Thr Phe Glu 
            340                 345                 350         


Ala Tyr Arg Lys Met Arg Thr Met Glu Leu Ile Lys Val Asp Asp Leu 
        355                 360                 365             


Ser Arg Glu Ser Leu Asp Ala Leu Ala His Ile Leu Thr Leu Asn Thr 
    370                 375                 380                 


Glu Arg Glu Gly Ile Glu Glu Ala Ile Arg Asp Arg Phe Thr Asn Lys 
385                 390                 395                 400 


Glu Phe Asn Gln Glu Gln Ile Asn Glu Leu Val Leu Phe Arg Lys Asn 
                405                 410                 415     


Asn Ser Ser Leu Phe Gly Lys Gly Trp His Asn Phe Ser Leu Lys Leu 
            420                 425                 430         


Met Lys Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met 
        435                 440                 445             


Thr Ile Leu Thr Arg Leu Gly Lys Gln Arg Val Lys Lys Ser Ser Asn 
    450                 455                 460                 


Arg Thr Asn Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn 
465                 470                 475                 480 


Pro Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Leu 
                485                 490                 495     


Ala Thr Lys Lys Tyr Gly Val Phe Asp Asn Ile Val Ile Glu Met Ala 
            500                 505                 510         


Arg Glu Ser Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Asn Ala Gln 
        515                 520                 525             


Lys Ala Asn Glu Asp Glu Lys Lys Ala Ala Leu Leu Lys Ala Ala His 
    530                 535                 540                 


Gln Phe Asn Gly Lys Glu Glu Leu Pro Asp Ser Ile Phe His Gly His 
545                 550                 555                 560 


Lys Glu Leu Leu Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys 
                565                 570                 575     


Cys Leu Tyr Thr Gly Lys Thr Ile Phe Ile Asn Asp Leu Ile His Asn 
            580                 585                 590         


Pro Tyr Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe 
        595                 600                 605             


Asp Asp Ser Leu Ala Asn Lys Val Leu Val Leu Ser Thr Ala Asn Gln 
    610                 615                 620                 


Glu Lys Gly Gln Arg Thr Pro Phe Gln Ser Leu Asp Ser Met Asp Gly 
625                 630                 635                 640 


Ala Trp Thr Tyr Arg Glu Phe Lys Ser Tyr Val Lys Gly Leu Lys Thr 
                645                 650                 655     


Leu Ser Asn Lys Lys Lys Asp Tyr Leu Leu Thr Glu Glu Asn Ile Asp 
            660                 665                 670         


Lys Ile Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr 
        675                 680                 685             


Arg Tyr Ser Ser Arg Val Val Leu Asn Ala Leu Gln Asp Phe Tyr Lys 
    690                 695                 700                 


Glu Arg Lys Phe Asp Thr Lys Ile Ser Val Val Arg Gly Gln Phe Thr 
705                 710                 715                 720 


Ser Gln Leu Arg Arg Lys Trp Arg Ile Glu Lys Thr Arg Glu Thr Tyr 
                725                 730                 735     


His His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu 
            740                 745                 750         


Asn Leu Trp Lys Lys Gln Asn Asn Pro Leu Ile Ser Tyr Lys Glu Asp 
        755                 760                 765             


Gln Phe Val Asp Pro Glu Thr Gly Glu Ile Leu Ser Leu Ser Asp Asp 
    770                 775                 780                 


Glu Tyr Lys Lys Leu Val Phe Lys Ala Pro Tyr Glu His Phe Val Asp 
785                 790                 795                 800 


Thr Leu Lys Ser Lys Lys Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Tyr Asn Arg Lys Ile Ser Gly Ala Thr Ile Cys Gly 
            820                 825                 830         


Thr Arg Lys Ala Gln Leu Gly Lys Asp Thr Gln Glu Glu Thr Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gln Lys Gly Tyr Glu Asp Phe 
    850                 855                 860                 


Ile Lys Lys Tyr Lys Lys Asp Lys Thr Gln Phe Leu Met Tyr His Lys 
865                 870                 875                 880 


Asp Pro Gln Thr Phe Glu Lys Val Ile Glu Glu Ile Leu Lys Thr Tyr 
                885                 890                 895     


Pro Asp Lys Glu Leu Asn Glu Lys Gly Lys Glu Val Ser Cys Asn Pro 
            900                 905                 910         


Phe Glu Lys Tyr Arg Gln Glu Asn Gly Pro Val Arg Lys Tyr Ser Lys 
        915                 920                 925             


Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Glu Val 
    930                 935                 940                 


Leu Gly Lys Asn Ile Asp Ile Thr Pro Lys Asn Ser Leu Asn Lys Val 
945                 950                 955                 960 


Val Leu Arg Ser Leu Asn Pro Trp Arg Thr Asp Val Tyr Phe Asn His 
                965                 970                 975     


Glu Thr Arg Lys Tyr Glu Phe Leu Gly Leu Lys Tyr Ser Asp Leu Arg 
            980                 985                 990         


Tyr Leu Lys Gly Glu His Arg Tyr  Gly Ile Leu Ile Gly  Asp Tyr Lys 
        995                 1000                 1005             


Lys Ile  Lys Asp Lys Glu Gly  Ile Glu Lys Glu Ser  Glu Phe Lys 
    1010                 1015                 1020             


Phe Thr  Leu Tyr Lys Asn Asp  Leu Ile Leu Ile Lys  Asp Thr Ala 
    1025                 1030                 1035             


Lys Gly  Lys Glu Glu Leu Phe  Arg Phe Trp Ser Arg  Thr Gly Lys 
    1040                 1045                 1050             


Asp Asn  Ala Lys Thr Phe Glu  Lys Asn Lys Ile Glu  Leu Lys Pro 
    1055                 1060                 1065             


Tyr Ser  Lys Ser Gln Phe Glu  Lys Gly Glu Asp Thr  Asn Val Leu 
    1070                 1075                 1080             


Gly Lys  Leu Tyr Ala Ser Ser  Asn Gln Leu Gln Lys  Ser Phe Gly 
    1085                 1090                 1095             


Thr Leu  Glu Asn Leu Ser Ile  Tyr Lys Val Arg Thr  Asp Val Leu 
    1100                 1105                 1110             


Gly Asn  Lys Tyr Phe Ile Lys  Lys Glu Gly Asp Lys  Pro Gln Leu 
    1115                 1120                 1125             


Asn Phe  Lys Lys Lys Leu 
    1130                 


<210> 542
<211> 1134
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans ST1

<400> 542
Met Ala Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Asp Lys Glu Thr Gly Lys Ile Ile His Val Asn 
            20                  25                  30          


Ser Arg Ile Phe Pro Ala Ala Thr Ala Asp Ser Asn Val Glu Arg Arg 
        35                  40                  45              


Gly Phe Arg Gln Gly Arg Arg Leu Val Arg Arg Lys Lys His Arg Lys 
    50                  55                  60                  


Val Arg Leu Ala Asp Leu Phe Leu Asp Ser Asn Leu Leu Thr Asp Phe 
65                  70                  75                  80  


Ser Lys Val Ser Leu Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly 
                85                  90                  95      


Leu Asn Glu Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Ser 
            100                 105                 110         


Ile Val Ser Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp 
        115                 120                 125             


Ser Gly Ala Asn Ser Ser Glu Tyr Gly Lys Ala Val Glu Glu Asn Arg 
    130                 135                 140                 


Lys Leu Leu Glu Asp Arg Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe 
145                 150                 155                 160 


Glu Lys Tyr Gly Lys Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly 
                165                 170                 175     


Glu Asn His Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Lys Lys 
            180                 185                 190         


Glu Ala Glu Arg Ile Leu Arg Arg Gln Gln Glu Phe Asn Met Arg Ile 
        195                 200                 205             


Ala Asp Glu Phe Ile Glu Ala Tyr Leu Thr Ile Leu Thr Gly Lys Arg 
    210                 215                 220                 


Lys Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly 
225                 230                 235                 240 


Arg Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu 
                245                 250                 255     


Ile Gly Lys Cys Thr Phe Tyr Pro Asp Glu Tyr Arg Ala Ala Lys Ala 
            260                 265                 270         


Ser Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu 
        275                 280                 285             


Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Arg Gln 
    290                 295                 300                 


Ile Ile Glu His Ala Lys Thr Val Lys Thr Leu Gly Ala Pro Thr Leu 
305                 310                 315                 320 


Leu Lys Tyr Ile Val Lys Leu Val Gly Cys Ser Ala Asp Asp Ile Lys 
                325                 330                 335     


Gly Tyr Arg Ile Asp Lys Ser Asp Lys Pro Glu Ile His Thr Phe Glu 
            340                 345                 350         


Ala Tyr Arg Lys Met Arg Thr Met Glu Leu Ile Lys Val Asp Asp Leu 
        355                 360                 365             


Ser Arg Glu Ser Leu Asp Ala Leu Ala His Ile Leu Thr Leu Asn Thr 
    370                 375                 380                 


Glu Arg Glu Gly Ile Glu Glu Ala Ile Arg Asp Arg Phe Thr Asn Lys 
385                 390                 395                 400 


Glu Phe Asn Gln Glu Gln Ile Asn Glu Leu Val Leu Phe Arg Lys Asn 
                405                 410                 415     


Asn Ser Ser Leu Phe Gly Lys Gly Trp His Asn Phe Ser Leu Lys Leu 
            420                 425                 430         


Met Lys Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met 
        435                 440                 445             


Thr Ile Leu Thr Arg Leu Gly Lys Gln Arg Val Lys Lys Ser Ser Asn 
    450                 455                 460                 


Arg Thr Asn Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn 
465                 470                 475                 480 


Pro Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Leu 
                485                 490                 495     


Ala Thr Lys Lys Tyr Gly Val Phe Asp Asn Ile Val Ile Glu Met Ala 
            500                 505                 510         


Arg Glu Ser Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Asn Ala Gln 
        515                 520                 525             


Lys Ala Asn Glu Asp Glu Lys Lys Ala Ala Leu Leu Lys Ala Ala His 
    530                 535                 540                 


Gln Phe Asn Gly Lys Glu Glu Leu Pro Asp Ser Ile Phe His Gly His 
545                 550                 555                 560 


Lys Glu Leu Leu Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys 
                565                 570                 575     


Cys Leu Tyr Thr Gly Lys Thr Ile Phe Ile Asn Asp Leu Ile His Asn 
            580                 585                 590         


Pro Tyr Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe 
        595                 600                 605             


Asp Asp Ser Leu Ala Asn Lys Val Leu Val Leu Ser Thr Ala Asn Gln 
    610                 615                 620                 


Glu Lys Gly Gln Arg Thr Pro Phe Gln Ser Leu Asp Ser Met Asp Gly 
625                 630                 635                 640 


Ala Trp Thr Tyr Arg Glu Phe Lys Ser Tyr Val Lys Gly Leu Lys Thr 
                645                 650                 655     


Leu Ser Asn Lys Lys Lys Asp Tyr Leu Leu Thr Glu Glu Asn Ile Asp 
            660                 665                 670         


Lys Ile Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr 
        675                 680                 685             


Arg Tyr Ser Ser Arg Val Val Leu Asn Ala Leu Gln Asp Phe Tyr Lys 
    690                 695                 700                 


Glu Arg Lys Phe Asp Thr Lys Ile Ser Val Val Arg Gly Gln Phe Thr 
705                 710                 715                 720 


Ser Gln Leu Arg Arg Lys Trp Arg Ile Glu Lys Thr Arg Glu Thr Tyr 
                725                 730                 735     


His His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu 
            740                 745                 750         


Asn Leu Trp Lys Lys Gln Asn Asn Pro Leu Ile Ser Tyr Lys Glu Asp 
        755                 760                 765             


Gln Phe Val Asp Pro Glu Thr Gly Glu Ile Leu Ser Leu Ser Asp Asp 
    770                 775                 780                 


Glu Tyr Lys Lys Leu Val Phe Lys Ala Pro Tyr Glu His Phe Val Asp 
785                 790                 795                 800 


Thr Leu Lys Ser Lys Lys Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Tyr Asn Arg Lys Ile Ser Gly Ala Thr Ile Cys Gly 
            820                 825                 830         


Thr Arg Lys Ala Gln Leu Gly Lys Asp Thr Gln Glu Glu Thr Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gln Lys Gly Tyr Glu Asp Phe 
    850                 855                 860                 


Ile Lys Lys Tyr Lys Lys Asp Lys Thr Gln Phe Leu Met Tyr His Lys 
865                 870                 875                 880 


Asp Pro Gln Thr Phe Glu Lys Val Ile Glu Glu Ile Leu Lys Thr Tyr 
                885                 890                 895     


Pro Asp Lys Glu Leu Asn Glu Lys Gly Lys Glu Val Ser Cys Asn Pro 
            900                 905                 910         


Phe Glu Lys Tyr Arg Gln Glu Asn Gly Pro Val Arg Lys Tyr Ser Lys 
        915                 920                 925             


Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Glu Val 
    930                 935                 940                 


Leu Gly Lys Asn Ile Asp Ile Thr Pro Lys Asn Ser Leu Asn Lys Val 
945                 950                 955                 960 


Val Leu Arg Ser Leu Asn Pro Trp Arg Thr Asp Val Tyr Phe Asn His 
                965                 970                 975     


Glu Thr Arg Lys Tyr Glu Phe Leu Gly Leu Lys Tyr Ser Asp Leu Arg 
            980                 985                 990         


Tyr Leu Lys Gly Glu His Arg Tyr  Gly Ile Leu Ile Gly  Asp Tyr Lys 
        995                 1000                 1005             


Lys Ile  Lys Asp Lys Glu Gly  Ile Glu Lys Glu Ser  Glu Phe Lys 
    1010                 1015                 1020             


Phe Thr  Leu Tyr Lys Asn Asp  Leu Ile Leu Ile Lys  Asp Thr Ala 
    1025                 1030                 1035             


Lys Gly  Lys Glu Glu Leu Phe  Arg Phe Trp Ser Arg  Thr Gly Lys 
    1040                 1045                 1050             


Asp Asn  Ala Lys Thr Phe Glu  Lys Asn Lys Ile Glu  Leu Lys Pro 
    1055                 1060                 1065             


Tyr Ser  Lys Ser Gln Phe Glu  Lys Gly Glu Asp Thr  Asn Val Leu 
    1070                 1075                 1080             


Gly Lys  Leu Tyr Ala Ser Ser  Asn Gln Leu Gln Lys  Ser Phe Gly 
    1085                 1090                 1095             


Thr Leu  Glu Asn Leu Ser Ile  Tyr Lys Val Arg Thr  Asp Val Leu 
    1100                 1105                 1110             


Gly Asn  Lys Tyr Phe Ile Lys  Lys Glu Gly Asp Lys  Pro Gln Leu 
    1115                 1120                 1125             


Asn Phe  Lys Lys Lys Leu 
    1130                 


<210> 543
<211> 1350
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans ST6

<400> 543
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Ser Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Asn Arg Met Arg 
865                 870                 875                 880 


Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu Ile Ser Gln Arg Lys 
                885                 890                 895     


Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu Asp Asp Lys Ala Gly 
            900                 905                 910         


Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 
        915                 920                 925             


Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu Phe Asp Asp Asn Asn 
    930                 935                 940                 


Lys Arg Ile Arg Lys Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val 
945                 950                 955                 960 


Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn 
                965                 970                 975     


Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Val Lys 
            980                 985                 990         


Ala Leu Leu Val Lys Tyr Ser Lys  Leu Glu Pro Glu Phe  Val Tyr Gly 
        995                 1000                 1005             


Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu Arg Lys  Thr Ala Thr 
    1010                 1015                 1020             


Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met Asn Met  Phe Lys Ser 
    1025                 1030                 1035             


Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val Glu Arg  Pro Met Ile 
    1040                 1045                 1050             


Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala Trp Asp  Lys Thr Lys 
    1055                 1060                 1065             


His Ile  Thr Thr Val Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1070                 1075                 1080             


Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile Gly Gln  Asn Gly Gly 
    1085                 1090                 1095             


Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu Glu Val  Ile Pro Ser 
    1100                 1105                 1110             


Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn Pro Glu  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro Ile Leu  Leu Ile Val 
    1130                 1135                 1140             


Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val Met Asp  Lys Lys Arg 
    1145                 1150                 1155             


Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys Asp Lys  Gly Tyr Gln 
    1160                 1165                 1170             


Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu Pro Lys  Tyr Thr Leu 
    1175                 1180                 1185             


Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu Trp Ala  Ser Ser Lys 
    1190                 1195                 1200             


Glu Val  His Lys Gly Asn Gln  Leu Val Val Ser Lys  Lys Ser Gln 
    1205                 1210                 1215             


Asp Leu  Leu Tyr His Ala His  His Leu Asp Asn Asp  Tyr Ser Asn 
    1220                 1225                 1230             


Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe Asp Ile  Leu Phe Asn 
    1235                 1240                 1245             


Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys Leu Gly  Lys Glu His 
    1250                 1255                 1260             


Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys Glu Arg  Asp Ser Ala 
    1265                 1270                 1275             


Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile Lys Leu  Leu Gly Phe 
    1280                 1285                 1290             


Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser Phe Leu  Gly Ile Lys 
    1295                 1300                 1305             


Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys Asp Tyr  Leu Leu Pro 
    1310                 1315                 1320             


Cys Met  Glu Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1325                 1330                 1335             


Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345                 1350 


<210> 544
<211> 1350
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans ST6

<400> 544
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Ser Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Asn Arg Met Arg 
865                 870                 875                 880 


Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu Ile Ser Gln Arg Lys 
                885                 890                 895     


Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu Asp Asp Lys Ala Gly 
            900                 905                 910         


Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 
        915                 920                 925             


Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu Phe Asp Asp Asn Asn 
    930                 935                 940                 


Lys Arg Ile Arg Lys Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val 
945                 950                 955                 960 


Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn 
                965                 970                 975     


Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Val Lys 
            980                 985                 990         


Ala Leu Leu Val Lys Tyr Ser Lys  Leu Glu Pro Glu Phe  Val Tyr Gly 
        995                 1000                 1005             


Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu Arg Lys  Thr Ala Thr 
    1010                 1015                 1020             


Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met Asn Met  Phe Lys Ser 
    1025                 1030                 1035             


Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val Glu Arg  Pro Met Ile 
    1040                 1045                 1050             


Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala Trp Asp  Lys Thr Lys 
    1055                 1060                 1065             


His Ile  Thr Thr Val Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1070                 1075                 1080             


Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile Gly Gln  Asn Gly Gly 
    1085                 1090                 1095             


Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu Glu Val  Ile Pro Ser 
    1100                 1105                 1110             


Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn Pro Glu  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro Ile Leu  Leu Ile Val 
    1130                 1135                 1140             


Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val Met Asp  Lys Lys Arg 
    1145                 1150                 1155             


Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys Asp Lys  Gly Tyr Gln 
    1160                 1165                 1170             


Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu Pro Lys  Tyr Thr Leu 
    1175                 1180                 1185             


Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu Trp Ala  Ser Ser Lys 
    1190                 1195                 1200             


Glu Val  His Lys Gly Asn Gln  Leu Val Val Ser Lys  Lys Ser Gln 
    1205                 1210                 1215             


Asp Leu  Leu Tyr His Ala His  His Leu Asp Asn Asp  Tyr Ser Asn 
    1220                 1225                 1230             


Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe Asp Ile  Leu Phe Asn 
    1235                 1240                 1245             


Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys Leu Gly  Lys Glu His 
    1250                 1255                 1260             


Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys Glu Arg  Asp Ser Ala 
    1265                 1270                 1275             


Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile Lys Leu  Leu Gly Phe 
    1280                 1285                 1290             


Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser Phe Leu  Gly Ile Lys 
    1295                 1300                 1305             


Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys Asp Tyr  Leu Leu Pro 
    1310                 1315                 1320             


Cys Met  Glu Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1325                 1330                 1335             


Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345                 1350 


<210> 545
<211> 1125
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans U2A

<400> 545
Met Thr Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Asn Ala Lys Thr Gly Asn Val Glu His Ala Ser 
            20                  25                  30          


Ser Arg Ile Phe Pro Ala Ala Asn Ala Asp Asn Asn Val Glu Arg Arg 
        35                  40                  45              


Ser Ala Arg Gly Gly Arg Arg Leu Ile Arg Arg Lys Lys His Arg Leu 
    50                  55                  60                  


Lys Arg Val Glu Asp Leu Phe Glu Lys Tyr Asn Ile Asp Thr Asp Phe 
65                  70                  75                  80  


Ser Asn Leu Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu Asn 
                85                  90                  95      


Glu Gln Leu Ser Asn Glu Glu Leu Phe Ala Ile Leu Lys Asn Ile Ala 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Val 
        115                 120                 125             


Gly Ser Ser Asp Tyr Ala Lys Ala Ile Asp Glu Asn Arg Lys Leu Leu 
    130                 135                 140                 


Lys Lys Gln Thr Pro Gly Glu Ile Gln Leu Lys Arg Leu Glu Lys Tyr 
145                 150                 155                 160 


Gly Gln Leu Arg Gly Asn Phe Thr Ile Gln Asp Glu Asn Gly Glu Tyr 
                165                 170                 175     


His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Val Lys Glu Ala 
            180                 185                 190         


Arg Arg Ile Leu Glu Thr Gln Ser Tyr Tyr Asn Lys Phe Ile Thr Glu 
        195                 200                 205             


Ser Phe Val Glu Asp Tyr Ile Lys Ile Leu Gln Gly Lys Arg Lys Tyr 
    210                 215                 220                 


Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile Tyr 
225                 230                 235                 240 


Arg Thr Asp Gly Glu Thr Leu Asp Asn Leu Phe Gly Ile Leu Ile Gly 
                245                 250                 255     


Lys Cys Gly Phe Tyr Pro Glu Glu Tyr Arg Ala Ala Lys Ala Ser Tyr 
            260                 265                 270         


Thr Ala Gln Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Thr Val 
        275                 280                 285             


Pro Thr Glu Thr Lys Lys Leu Ser Thr Glu Gln Lys Tyr Gln Leu Val 
    290                 295                 300                 


Asp Phe Ala Lys Thr Ala Ser Thr Leu Gly Ala Ala Lys Leu Leu Lys 
305                 310                 315                 320 


Glu Ile Ala Lys Leu Val Gly Cys Gln Val Glu Glu Ile Lys Gly Tyr 
                325                 330                 335     


Arg Leu Asp Asn Lys Asp Lys Pro Asp Leu His Thr Phe Glu Pro Phe 
            340                 345                 350         


Arg Lys Leu Lys Ser Asn Leu Thr Thr Ile Ala Val Glu Asn Leu Ser 
        355                 360                 365             


Ile Thr Thr Leu Asp Thr Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Glu Ala Ile Gln Lys Glu Leu Pro Asn Ile Phe 
385                 390                 395                 400 


Ser Asp Glu Gln Ile Thr Glu Ile Ile Ala Val Arg Lys Lys Asn Ser 
                405                 410                 415     


Gln Ile Phe Gly Lys Gly Trp His Ser Phe Ser Ile Lys Leu Met Lys 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Lys Lys Val Lys Thr Asn Ser Lys Ile Thr Asn Arg 
    450                 455                 460                 


Thr Lys Tyr Ile Asn Glu Glu Glu Ile Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ser Lys Ser Ile Arg Gln Thr Val Lys Ile Ile Asn Ala Thr 
                485                 490                 495     


Ile Lys Lys Tyr Gly Ala Phe Asp Gln Ile Ile Ile Glu Met Pro Arg 
            500                 505                 510         


Glu Ser Asn Glu Glu Asp Glu Arg Lys Phe Ile Ala Asp Leu Gln Lys 
        515                 520                 525             


Ser Asn Ala Lys Glu Lys Asp Asp Ala Met Lys Gln Ala Ala Leu Leu 
    530                 535                 540                 


Tyr Asn Gly Lys Asp Glu Leu Pro His Asp Val Phe His Gly His Lys 
545                 550                 555                 560 


Glu Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Ser Gly Lys His Ile Asp Ile His Asp Leu Ile His Asn Gln 
            580                 585                 590         


His Met Phe Glu Ile Asp His Val Leu Pro Leu Ser Leu Ser Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ser Trp Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Phe Gln Ala Leu Pro Gln Met Ala Ser Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Arg Asp Tyr Ile Ser Lys Gln Lys Gly Ile 
                645                 650                 655     


Ser Lys Lys Lys Arg Asp Tyr Leu Leu Thr Glu Gln Asp Ile Asn Lys 
            660                 665                 670         


Val Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Val Ser Arg Val Val Leu Asn Thr Leu Gln Asp Ala Leu Lys Val 
    690                 695                 700                 


Met Asn Lys Glu Thr Lys Ile Ser Val Ile Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg Gln Trp Arg Ile Asp Lys Ser Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg 
            740                 745                 750         


Leu Trp Lys Lys Gln Asn Asn Pro Met Phe Ala Glu Asp Lys His Gly 
        755                 760                 765             


Gln Lys Ile Asn Leu Asp Thr Gly Glu Val Leu Ser Asp Asp Ala Tyr 
    770                 775                 780                 


Lys Glu Leu Val Tyr Gln Ala Pro Tyr Gln Gly Phe Val Asn Thr Ile 
785                 790                 795                 800 


Ser Ser Lys Ser Phe Glu Asp Glu Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Val Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Gln Ala Gln Leu Gly Lys Asp Lys Lys Glu Glu Thr Tyr Val Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ser Gln Ala Gly Tyr Asp Ala Phe Arg Lys 
    850                 855                 860                 


Lys Tyr Asp Lys Asp Lys Ala Val Phe Leu Met Tyr Gln Lys Asp Pro 
865                 870                 875                 880 


Glu Thr Trp Glu Lys Val Ile Glu Val Ile Leu Arg Asp Tyr Lys Glu 
                885                 890                 895     


Leu Asp Asp Lys Gly Lys Glu Ile Gly Asn Pro Phe Glu Arg Tyr Lys 
            900                 905                 910         


Val Lys His Gly Phe Val Arg Lys Tyr Ser Arg Lys Asn Lys Gly Thr 
        915                 920                 925             


Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly Asn His Ile 
    930                 935                 940                 


Asp Ile Thr Pro Asn Asn Ser Lys His Ser Val Val Leu Gln Ser Ile 
945                 950                 955                 960 


Asn Pro Trp Arg Ala Asp Leu Tyr Phe Asn Pro Glu Thr Thr Lys Tyr 
                965                 970                 975     


Glu Leu Met Gly Leu Lys Tyr Ala Asp Leu Ser Phe Glu Lys Gly Thr 
            980                 985                 990         


Gly Lys Tyr Ser Ile Ser Arg Glu  Lys Tyr Asp Glu Ile  Lys Glu Arg 
        995                 1000                 1005             


Glu Gly  Ile Ser Ser Lys Ser  Glu Phe Lys Phe Thr  Leu Tyr Lys 
    1010                 1015                 1020             


Asn Asp  Leu Ile Leu Val Lys  Asp Ile Gly Asn His  Lys Glu Leu 
    1025                 1030                 1035             


Ile Ala  Arg Phe Asn Ser Lys  Asn Asp Thr Ser Lys  His Tyr Val 
    1040                 1045                 1050             


Glu Leu  Lys Pro Trp Asn Lys  Ala Lys Phe Asp Ser  Glu Glu Glu 
    1055                 1060                 1065             


Leu Ile  Pro Ala Phe Gly Lys  Val Ala Lys Ser Gly  Gln Phe Ile 
    1070                 1075                 1080             


Lys Gly  Leu Asn Lys Pro Asp  Leu Ser Ile Tyr Lys  Val Lys Thr 
    1085                 1090                 1095             


Asp Ile  Leu Gly His Lys Tyr  Tyr Ile Lys Lys Glu  Gly Asp Lys 
    1100                 1105                 1110             


Pro Lys  Leu Asn Phe Glu Asn  Lys Ile Lys Asn Lys  
    1115                 1120                 1125 


<210> 546
<211> 1125
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans U2A

<400> 546
Met Thr Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Asn Ala Lys Thr Gly Asn Val Glu His Ala Ser 
            20                  25                  30          


Ser Arg Ile Phe Pro Ala Ala Asn Ala Asp Asn Asn Val Glu Arg Arg 
        35                  40                  45              


Ser Ala Arg Gly Gly Arg Arg Leu Ile Arg Arg Lys Lys His Arg Leu 
    50                  55                  60                  


Lys Arg Val Glu Asp Leu Phe Glu Lys Tyr Asn Ile Asp Thr Asp Phe 
65                  70                  75                  80  


Ser Asn Leu Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu Asn 
                85                  90                  95      


Glu Gln Leu Ser Asn Glu Glu Leu Phe Ala Ile Leu Lys Asn Ile Ala 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Val 
        115                 120                 125             


Gly Ser Ser Asp Tyr Ala Lys Ala Ile Asp Glu Asn Arg Lys Leu Leu 
    130                 135                 140                 


Lys Lys Gln Thr Pro Gly Glu Ile Gln Leu Lys Arg Leu Glu Lys Tyr 
145                 150                 155                 160 


Gly Gln Leu Arg Gly Asn Phe Thr Ile Gln Asp Glu Asn Gly Glu Tyr 
                165                 170                 175     


His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Val Lys Glu Ala 
            180                 185                 190         


Arg Arg Ile Leu Glu Thr Gln Ser Tyr Tyr Asn Lys Phe Ile Thr Glu 
        195                 200                 205             


Ser Phe Val Glu Asp Tyr Ile Lys Ile Leu Gln Gly Lys Arg Lys Tyr 
    210                 215                 220                 


Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile Tyr 
225                 230                 235                 240 


Arg Thr Asp Gly Glu Thr Leu Asp Asn Leu Phe Gly Ile Leu Ile Gly 
                245                 250                 255     


Lys Cys Gly Phe Tyr Pro Glu Glu Tyr Arg Ala Ala Lys Ala Ser Tyr 
            260                 265                 270         


Thr Ala Gln Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Thr Val 
        275                 280                 285             


Pro Thr Glu Thr Lys Lys Leu Ser Thr Glu Gln Lys Tyr Gln Leu Val 
    290                 295                 300                 


Asp Phe Ala Lys Thr Ala Ser Thr Leu Gly Ala Ala Lys Leu Leu Lys 
305                 310                 315                 320 


Glu Ile Ala Lys Leu Val Gly Cys Gln Val Glu Glu Ile Lys Gly Tyr 
                325                 330                 335     


Arg Leu Asp Asn Lys Asp Lys Pro Asp Leu His Thr Phe Glu Pro Phe 
            340                 345                 350         


Arg Lys Leu Lys Ser Asn Leu Thr Thr Ile Ala Val Glu Asn Leu Ser 
        355                 360                 365             


Ile Thr Thr Leu Asp Thr Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Glu Ala Ile Gln Lys Glu Leu Pro Asn Ile Phe 
385                 390                 395                 400 


Ser Asp Glu Gln Ile Thr Glu Ile Ile Ala Val Arg Lys Lys Asn Ser 
                405                 410                 415     


Gln Ile Phe Gly Lys Gly Trp His Ser Phe Ser Ile Lys Leu Met Lys 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Lys Lys Val Lys Thr Asn Ser Lys Ile Thr Asn Arg 
    450                 455                 460                 


Thr Lys Tyr Ile Asn Glu Glu Glu Ile Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ser Lys Ser Ile Arg Gln Thr Val Lys Ile Ile Asn Ala Thr 
                485                 490                 495     


Ile Lys Lys Tyr Gly Ala Phe Asp Gln Ile Ile Ile Glu Met Pro Arg 
            500                 505                 510         


Glu Ser Asn Glu Glu Asp Glu Arg Lys Phe Ile Ala Asp Leu Gln Lys 
        515                 520                 525             


Ser Asn Ala Lys Glu Lys Asp Asp Ala Met Lys Gln Ala Ala Leu Leu 
    530                 535                 540                 


Tyr Asn Gly Lys Asp Glu Leu Pro His Asp Val Phe His Gly His Lys 
545                 550                 555                 560 


Glu Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Ser Gly Lys His Ile Asp Ile His Asp Leu Ile His Asn Gln 
            580                 585                 590         


His Met Phe Glu Ile Asp His Val Leu Pro Leu Ser Leu Ser Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ser Trp Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Phe Gln Ala Leu Pro Gln Met Ala Ser Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Arg Asp Tyr Ile Ser Lys Gln Lys Gly Ile 
                645                 650                 655     


Ser Lys Lys Lys Arg Asp Tyr Leu Leu Thr Glu Gln Asp Ile Asn Lys 
            660                 665                 670         


Val Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Val Ser Arg Val Val Leu Asn Thr Leu Gln Asp Ala Leu Lys Val 
    690                 695                 700                 


Met Asn Lys Glu Thr Lys Ile Ser Val Ile Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg Gln Trp Arg Ile Asp Lys Ser Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg 
            740                 745                 750         


Leu Trp Lys Lys Gln Asn Asn Pro Met Phe Ala Glu Asp Lys His Gly 
        755                 760                 765             


Gln Lys Ile Asn Leu Asp Thr Gly Glu Val Leu Ser Asp Asp Ala Tyr 
    770                 775                 780                 


Lys Glu Leu Val Tyr Gln Ala Pro Tyr Gln Gly Phe Val Asn Thr Ile 
785                 790                 795                 800 


Ser Ser Lys Ser Phe Glu Asp Glu Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Val Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Gln Ala Gln Leu Gly Lys Asp Lys Lys Glu Glu Thr Tyr Val Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ser Gln Ala Gly Tyr Asp Ala Phe Arg Lys 
    850                 855                 860                 


Lys Tyr Asp Lys Asp Lys Ala Val Phe Leu Met Tyr Gln Lys Asp Pro 
865                 870                 875                 880 


Glu Thr Trp Glu Lys Val Ile Glu Val Ile Leu Arg Asp Tyr Lys Glu 
                885                 890                 895     


Leu Asp Asp Lys Gly Lys Glu Ile Gly Asn Pro Phe Glu Arg Tyr Lys 
            900                 905                 910         


Val Lys His Gly Phe Val Arg Lys Tyr Ser Arg Lys Asn Lys Gly Thr 
        915                 920                 925             


Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly Asn His Ile 
    930                 935                 940                 


Asp Ile Thr Pro Asn Asn Ser Lys His Ser Val Val Leu Gln Ser Ile 
945                 950                 955                 960 


Asn Pro Trp Arg Ala Asp Leu Tyr Phe Asn Pro Glu Thr Thr Lys Tyr 
                965                 970                 975     


Glu Leu Met Gly Leu Lys Tyr Ala Asp Leu Ser Phe Glu Lys Gly Thr 
            980                 985                 990         


Gly Lys Tyr Ser Ile Ser Arg Glu  Lys Tyr Asp Glu Ile  Lys Glu Arg 
        995                 1000                 1005             


Glu Gly  Ile Ser Ser Lys Ser  Glu Phe Lys Phe Thr  Leu Tyr Lys 
    1010                 1015                 1020             


Asn Asp  Leu Ile Leu Val Lys  Asp Ile Gly Asn His  Lys Glu Leu 
    1025                 1030                 1035             


Ile Ala  Arg Phe Asn Ser Lys  Asn Asp Thr Ser Lys  His Tyr Val 
    1040                 1045                 1050             


Glu Leu  Lys Pro Trp Asn Lys  Ala Lys Phe Asp Ser  Glu Glu Glu 
    1055                 1060                 1065             


Leu Ile  Pro Ala Phe Gly Lys  Val Ala Lys Ser Gly  Gln Phe Ile 
    1070                 1075                 1080             


Lys Gly  Leu Asn Lys Pro Asp  Leu Ser Ile Tyr Lys  Val Lys Thr 
    1085                 1090                 1095             


Asp Ile  Leu Gly His Lys Tyr  Tyr Ile Lys Lys Glu  Gly Asp Lys 
    1100                 1105                 1110             


Pro Lys  Leu Asn Phe Glu Asn  Lys Ile Lys Asn Lys  
    1115                 1120                 1125 


<210> 547
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans UA159

<400> 547
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 548
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans W6

<400> 548
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 549
<211> 1121
<212> PRT
<213> Streptococcus oralis


<220>
<223> Streptococcus oralis SK1074

<400> 549
Met Asn Gly Leu Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Glu Lys Asn Ser Gly Lys Ile Ile His Ala Asn Ser 
            20                  25                  30          


Arg Leu Phe Pro Ala Ala Thr Ala Asp Asn Asn Val Glu Arg Arg Lys 
        35                  40                  45              


Asn Arg Gln Ala Arg Arg Leu Asn Arg Arg Lys Lys His Arg Gly Val 
    50                  55                  60                  


Arg Phe Gln Asp Leu Phe Glu Asp Tyr Gly Leu Leu Thr Asp Phe Ser 
65                  70                  75                  80  


Lys Val Ser Ile Asn Leu Asn Pro Tyr Arg Leu Arg Val Asp Gly Leu 
                85                  90                  95      


Asn Gln Gln Leu Thr Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Ile 
            100                 105                 110         


Val Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly 
        115                 120                 125             


Gly Ala Val Ser Ser Asp Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 
    130                 135                 140                 


Leu Leu Ala Glu Gln Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe Glu 
145                 150                 155                 160 


Lys Tyr Gly Gln Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly Glu 
                165                 170                 175     


Lys Cys Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Arg Lys Glu 
            180                 185                 190         


Ala Glu Lys Ile Leu Arg Lys Gln Gln Glu Phe Asn Asn Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Glu Asp Tyr Leu Lys Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Val Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asn Glu Tyr Arg Ala Ser Lys Ser Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Lys Val Ile 
    290                 295                 300                 


Val Glu Tyr Ala Lys Glu Ala Lys Thr Leu Gly Ala Ser Thr Leu Leu 
305                 310                 315                 320 


Lys Tyr Ile Val Lys Met Ile Asp Ala Ser Val Asp Gln Ile Ser Gly 
                325                 330                 335     


Tyr Arg Val Asp Val Asn Asn Lys Pro Glu Met His Thr Phe Glu Val 
            340                 345                 350         


Tyr Arg Lys Met Gln Ser Leu Glu Thr Ile Ser Val Gly Glu Leu Ser 
        355                 360                 365             


Arg Asn Val Leu Asp Glu Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Glu Ala Ile Asn Ser Lys Leu Met Gly Val Phe 
385                 390                 395                 400 


Ser Gln Asp Gln Val Leu Glu Leu Val Gln Phe Arg Lys Asn Asn Ser 
                405                 410                 415     


Ser Leu Phe Ser Lys Gly Trp His Asn Phe Ser Leu Lys Leu Met Met 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Gly Lys Gln Lys Ser Lys Glu Thr Ser Lys Arg Thr 
    450                 455                 460                 


Lys Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn Pro Val 
465                 470                 475                 480 


Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Glu Ala Thr 
                485                 490                 495     


Lys Lys His Gly Ile Phe Asp Asn Ile Val Ile Glu Met Ala Arg Glu 
            500                 505                 510         


Asn Asn Glu Glu Asp Ala Lys Lys Asp Tyr Ile Lys Arg Gln Lys Ala 
        515                 520                 525             


Asn Gln Asp Glu Lys Asn Ala Ala Met Glu Lys Ala Ala Phe Gln Tyr 
    530                 535                 540                 


Asn Gly Lys Lys Glu Leu Pro Gly Asn Ile Phe Asn Gly His Lys Glu 
545                 550                 555                 560 


Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys Cys Leu 
                565                 570                 575     


Tyr Thr Gly Lys Thr Ile Pro Ile Ser Asp Leu Ile His Asn Gln Tyr 
            580                 585                 590         


Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp Asp 
        595                 600                 605             


Ser Leu Ser Asn Lys Val Leu Val His Ala Thr Ala Asn Gln Glu Lys 
    610                 615                 620                 


Gly Gln Arg Thr Pro Phe Gln Ala Leu Asp Ser Met Asp Asp Ala Trp 
625                 630                 635                 640 


Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys Asp Leu Lys Ser Leu Ser 
                645                 650                 655     


Asn Lys Lys Lys Asp Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys Ile 
            660                 665                 670         


Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg Tyr 
        675                 680                 685             


Ser Ser Arg Val Val Leu Asn Ala Leu Gln Asp Phe Tyr Lys Ser His 
    690                 695                 700                 


Gln Phe Asp Thr Thr Ile Ser Val Val Arg Gly Gln Phe Thr Ser Gln 
705                 710                 715                 720 


Leu Arg Arg Lys Trp Gly Leu Glu Lys Ser Arg Glu Thr Tyr His His 
                725                 730                 735     


His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg Leu 
            740                 745                 750         


Trp Lys Lys Gln Asn Asn Pro Leu Ile Thr Tyr Lys Glu Gly Gln Phe 
        755                 760                 765             


Val Asp Ser Gln Thr Gly Glu Ile Ile Ser Leu Thr Asp Asp Glu Tyr 
    770                 775                 780                 


Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp Thr Leu 
785                 790                 795                 800 


His Ser Lys Thr Phe Glu Asp Gly Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Tyr Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Lys Ala Lys Leu Asp Lys Asp Lys Ser Glu Glu Thr Tyr Val Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ser Gln Ala Gly Tyr Asp Ala Phe Ile Lys 
    850                 855                 860                 


Ile Tyr Asn Lys Asp Lys Arg Lys Phe Leu Met Tyr His Lys Asp Pro 
865                 870                 875                 880 


Gln Thr Phe Glu Lys Val Ile Glu Glu Ile Leu Arg Thr Tyr Pro Ser 
                885                 890                 895     


Lys Glu Arg Asn Asp Lys Asn Lys Glu Val Pro Cys Asn Pro Phe Glu 
            900                 905                 910         


Lys Tyr Arg Gln Glu Asn Gly Pro Ile Arg Lys Tyr Ser Lys Lys Gly 
        915                 920                 925             


Asn Gly Pro Glu Ile Lys Cys Leu Lys Tyr Tyr Asp Asn Lys Leu Gly 
    930                 935                 940                 


Asn Tyr Ile Asp Ile Ser Pro Asp Gly Ser Asp Asn Gln Val Val Leu 
945                 950                 955                 960 


Gln Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn His Gln Thr 
                965                 970                 975     


Lys Glu Tyr Glu Leu Met Gly Leu Lys Tyr Ser Asp Leu Ser Phe Glu 
            980                 985                 990         


Lys Gly Ser Gly Lys Tyr Ser Ile  Ser Asn Glu Lys Tyr  Asn Ser Ile 
        995                 1000                 1005             


Lys Arg  Ile Glu Gly Val Asn  Glu Gln Ser Glu Phe  Lys Phe Thr 
    1010                 1015                 1020             


Leu Tyr  Lys Asn Asp Leu Ile  Leu Ile Lys Asp Ser  Glu Asn Asn 
    1025                 1030                 1035             


Glu Gln  Lys Leu Phe Arg Phe  Asn Ser Arg Asn Asp  Thr Ala Lys 
    1040                 1045                 1050             


His Tyr  Val Glu Leu Lys Pro  Tyr Asp Lys Ala Arg  Phe Asp Gly 
    1055                 1060                 1065             


Gln Gln  Glu Leu Ile Thr Ile  Leu Gly Asn Val Ala  Lys Gly Gly 
    1070                 1075                 1080             


Gln Cys  Leu Lys Gly Leu Asn  Lys Ser Asn Ile Ser  Ile Phe Lys 
    1085                 1090                 1095             


Val Lys  Thr Asp Val Leu Gly  Lys Lys His Ile Ile  Lys Lys Glu 
    1100                 1105                 1110             


Gly Asp  Glu Pro Lys Leu Lys  Phe 
    1115                 1120     


<210> 550
<211> 1373
<212> PRT
<213> Streptococcus oralis


<220>
<223> Streptococcus oralis SK304

<400> 550
Met Glu Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Arg Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Ala Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Ile Pro Glu Asp Lys 
            100                 105                 110         


Lys Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ile Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Asp Thr Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asn Asn Thr Phe Glu Gly Asn Ser Leu Ser Gly Gln Asn Val Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Arg Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Val Ala Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Thr Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Thr Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ser Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Glu Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Ser Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Arg 
    530                 535                 540                 


Gln Lys Lys Asp Ile Phe Tyr Thr Leu Phe Lys Ala Glu Asp Lys Arg 
545                 550                 555                 560 


Lys Val Thr Glu Lys Asp Ile Ile Gln Tyr Leu His Thr Val Asp Gly 
                565                 570                 575     


Tyr Asp Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser 
            580                 585                 590         


Leu Ser Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe 
        595                 600                 605             


Met Asp Asp Pro Asn Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr 
    610                 615                 620                 


Leu Thr Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln 
625                 630                 635                 640 


Tyr Asp Ser Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Lys Leu Ser Ser Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Gln Thr Gly Lys Thr Ile Leu Asp Tyr Leu Met Asp Asp 
        675                 680                 685             


Gly Tyr Asn Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Glu Leu 
    690                 695                 700                 


Ser Phe Lys Glu Ile Ile Lys Lys Ala Gln Val Val Gly Lys Thr Asp 
705                 710                 715                 720 


Asp Val Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Ile Lys Leu Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly His Glu Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Ile Glu Asp Ser Leu Lys Ile Leu Ala Ser Gly Leu Asn Ala Lys Ile 
785                 790                 795                 800 


Leu Lys Glu His Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Lys Pro 
            820                 825                 830         


Leu Asp Ile Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Leu Lys Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val 
865                 870                 875                 880 


Val Glu Lys Met Lys Thr Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu 
                885                 890                 895     


Ile Ser Tyr Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Asp Glu Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Tyr 
    930                 935                 940                 


Asn Thr Glu Val Asn Glu Lys Asp Lys Lys Asn Arg Thr Val Lys Ile 
945                 950                 955                 960 


Ile Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Arg 
                965                 970                 975     


Leu Tyr Lys Ile Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Lys Lys  Tyr Pro Lys 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Gln Lys  Tyr Asp Leu 
    1010                 1015                 1020             


Lys Arg  Tyr Ile Ser Arg Ser  Lys Asp Pro Lys Glu  Ile Glu Lys 
    1025                 1030                 1035             


Ala Thr  Glu Lys Tyr Phe Phe  Tyr Ser Asn Leu Leu  Asn Phe Phe 
    1040                 1045                 1050             


Lys Glu  Glu Val His Tyr Ala  Asp Gly Thr Ile Val  Lys Arg Glu 
    1055                 1060                 1065             


Asn Ile  Glu Tyr Ser Lys Asp  Thr Gly Glu Ile Ala  Trp Asn Lys 
    1070                 1075                 1080             


Glu Lys  Asp Phe Ala Thr Ile  Lys Lys Val Leu Ser  Leu Pro Gln 
    1085                 1090                 1095             


Val Asn  Ile Val Lys Lys Arg  Glu Val Gln Thr Gly  Gly Phe Ser 
    1100                 1105                 1110             


Lys Glu  Ser Ile Leu Pro Lys  Gly Asn Ser Asp Lys  Leu Ile Pro 
    1115                 1120                 1125             


Arg Lys  Thr Lys Asp Ile Leu  Trp Asp Thr Thr Lys  Tyr Gly Gly 
    1130                 1135                 1140             


Phe Asp  Ser Pro Val Ile Ala  Tyr Ser Ile Leu Leu  Ile Ala Asp 
    1145                 1150                 1155             


Ile Glu  Lys Gly Lys Ala Lys  Arg Leu Lys Thr Val  Lys Thr Leu 
    1160                 1165                 1170             


Val Gly  Ile Thr Ile Met Glu  Lys Ala Thr Phe Glu  Lys Ser Pro 
    1175                 1180                 1185             


Ile Ala  Phe Leu Glu Asn Lys  Gly Tyr His Asn Val  Arg Lys Glu 
    1190                 1195                 1200             


Asn Ile  Leu Cys Leu Pro Lys  Tyr Ser Leu Phe Glu  Leu Lys Asn 
    1205                 1210                 1215             


Gly Arg  Arg Arg Met Leu Ala  Ser Ala Lys Glu Leu  Gln Lys Gly 
    1220                 1225                 1230             


Asn Glu  Ile Val Leu Pro Val  His Leu Thr Thr Leu  Leu Tyr His 
    1235                 1240                 1245             


Ala Lys  Asn Ile His Arg Leu  Asp Glu Pro Glu His  Leu Glu Tyr 
    1250                 1255                 1260             


Ile Gln  Lys His Arg Asn Glu  Phe Lys Gly Leu Leu  Asn Leu Val 
    1265                 1270                 1275             


Ser Glu  Phe Ser Gln Lys Tyr  Val Leu Ala Asp Ala  Asn Leu Glu 
    1280                 1285                 1290             


Lys Ile  Lys Asn Leu Tyr Ala  Asp Asn Glu Gln Ala  Asp Ile Glu 
    1295                 1300                 1305             


Ile Leu  Ala Asn Ser Phe Ile  Asn Leu Leu Thr Phe  Thr Ala Leu 
    1310                 1315                 1320             


Gly Ala  Pro Ala Ala Phe Lys  Phe Phe Gly Lys Asp  Val Asp Arg 
    1325                 1330                 1335             


Lys Arg  Tyr Thr Thr Val Ser  Glu Ile Leu Asn Ala  Thr Leu Ile 
    1340                 1345                 1350             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1355                 1360                 1365             


Lys Leu  Gly Glu Asp 
    1370             


<210> 551
<211> 1134
<212> PRT
<213> Streptococcus oralis


<220>
<223> Streptococcus oralis SK313

<400> 551
Met Asn Gly Leu Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Glu Lys Asn Ser Gly Lys Ile Val His Ala Ser Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Thr Ala Asp Asn Asn Val Glu Arg Arg Lys 
        35                  40                  45              


Asn Arg Gln Ala Arg Arg Leu His Arg Arg Lys Lys His Arg Gly Ala 
    50                  55                  60                  


Arg Leu Lys Asp Leu Phe Glu Tyr Tyr Gly Leu Leu Thr Asp Phe Ser 
65                  70                  75                  80  


Lys Val Ser Ile Asn Leu Asn Pro Tyr Arg Leu Arg Val Asp Gly Leu 
                85                  90                  95      


Asp Gln Gln Leu Thr Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Ile 
            100                 105                 110         


Val Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly 
        115                 120                 125             


Gly Thr Val Ser Ser Asp Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 
    130                 135                 140                 


Leu Leu Ala Glu Gln Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe Glu 
145                 150                 155                 160 


Lys Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Val Glu Asn Ser Glu 
                165                 170                 175     


Lys Cys Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Lys Lys Glu 
            180                 185                 190         


Ala Glu Arg Ile Leu Arg Lys Gln Gln Glu Phe Asn Asn Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Glu Asp Tyr Leu Lys Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Phe Arg Thr Asp Gly Ala Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asn Glu Tyr Arg Ala Ser Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Lys Thr Ile 
    290                 295                 300                 


Ile Glu Tyr Ala Lys Ser Ala Lys Thr Leu Gly Ala Ser Thr Leu Leu 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Met Ile Asp Ala Ser Val Asp Gln Ile Arg Gly 
                325                 330                 335     


Tyr Arg Val Asp Val Asn Asn Lys Pro Glu Met His Thr Phe Glu Val 
            340                 345                 350         


Tyr Arg Lys Met Gln Ser Leu Glu Thr Ile Ser Val Gly Glu Leu Ser 
        355                 360                 365             


Arg Asn Ile Leu Asp Glu Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Glu Ala Ile Asn Thr Lys Leu Arg Asp Ser Phe 
385                 390                 395                 400 


Ser Gln Asp Gln Val Leu Glu Leu Val Gln Phe Arg Lys Asn Asn Ser 
                405                 410                 415     


Ser Leu Phe Ser Lys Gly Trp His Asn Phe Ser Leu Lys Leu Met Met 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Gly Lys Gln Lys Ser Lys Glu Thr Ser Lys Arg Thr 
    450                 455                 460                 


Lys Tyr Ile Asp Glu Lys Glu Val Thr Glu Glu Ile Tyr Asn Pro Val 
465                 470                 475                 480 


Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Glu Ala Thr 
                485                 490                 495     


Lys Lys His Gly Ile Phe Asp Asn Ile Val Ile Glu Met Ala Arg Glu 
            500                 505                 510         


Asn Asn Glu Glu Asp Ala Lys Lys Asp Tyr Ile Lys Arg Gln Lys Ala 
        515                 520                 525             


Asn Gln Asp Glu Lys Tyr Ala Ala Met Glu Lys Ala Ala Phe Gln Tyr 
    530                 535                 540                 


Asn Gly Lys Lys Glu Leu Pro Asp Asn Ile Phe His Gly His Lys Glu 
545                 550                 555                 560 


Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys Cys Leu 
                565                 570                 575     


Tyr Thr Gly Lys Ser Ile Pro Ile Ser Asp Leu Ile His Asn Gln Tyr 
            580                 585                 590         


Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp Asp 
        595                 600                 605             


Ser Leu Ser Asn Lys Val Leu Val Leu Ala Thr Ala Asn Gln Glu Lys 
    610                 615                 620                 


Gly Gln Arg Thr Pro Phe Gln Ala Leu Asp Ser Met Asp Asp Ala Trp 
625                 630                 635                 640 


Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys Glu Ser Lys Leu Leu Gly 
                645                 650                 655     


Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys Ile 
            660                 665                 670         


Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg Tyr 
        675                 680                 685             


Ser Ser Arg Val Val Leu Asn Ala Leu Gln Asp Phe Tyr Lys Asn His 
    690                 695                 700                 


Asn Phe Asp Thr Thr Ile Ser Val Val Arg Gly Gln Phe Thr Ser Gln 
705                 710                 715                 720 


Leu Arg Arg Lys Trp Gly Leu Glu Lys Ser Arg Glu Thr Tyr His His 
                725                 730                 735     


His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg Leu 
            740                 745                 750         


Trp Lys Lys Gln Asn Asn Pro Leu Ile Ala Tyr Lys Glu Gly Gln Phe 
        755                 760                 765             


Val Asp Ser Gln Thr Gly Glu Ile Ile Ser Leu Thr Asp Asp Glu Tyr 
    770                 775                 780                 


Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp Thr Leu 
785                 790                 795                 800 


Ser Ser Lys Thr Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Lys Ala Lys Leu Asp Lys Glu Lys Lys Glu Tyr Thr Tyr Thr Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ser Leu Gly Thr Lys Thr Pro Ser Lys Thr 
    850                 855                 860                 


Gly Phe Tyr Lys Phe Leu Asp Leu Tyr Asn Lys Asp Lys Ser Gln Phe 
865                 870                 875                 880 


Leu Met Phe Gln Lys Asp Arg Lys Thr Trp Asp Glu Val Ile Glu Lys 
                885                 890                 895     


Ile Met Glu Gln Tyr Arg Pro Phe Lys Glu Tyr Asp Lys Ala Gly Lys 
            900                 905                 910         


Leu Val Asp Phe Asn Pro Phe Glu Lys Tyr Arg Gln Glu Asn Gly Pro 
        915                 920                 925             


Ile Arg Lys Tyr Ser Lys Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu 
    930                 935                 940                 


Lys Tyr Tyr Asp Ile Leu Leu Gly Lys His Lys Asn Ile Thr Pro Glu 
945                 950                 955                 960 


Gly Ser Arg Asn Thr Val Ala Leu Leu Ser Leu Asn Pro Trp Arg Thr 
                965                 970                 975     


Asp Val Tyr Tyr Asn Met Glu Thr Lys Lys Tyr Glu Phe Leu Gly Leu 
            980                 985                 990         


Lys Tyr Ala Asp Leu Pro Phe Glu  Glu Gly Gly Ala Tyr  Gly Ile Ser 
        995                 1000                 1005             


Thr Glu  Thr Tyr Asn Glu Leu  Arg Glu Lys Glu Gly  Ile Gly Lys 
    1010                 1015                 1020             


Asn Ser  Glu Phe Lys Phe Thr  Leu Tyr Lys Asn Asp  Leu Ile Leu 
    1025                 1030                 1035             


Ile Lys  Asp Thr Glu Thr Asn  Cys Gln Gln Phe Phe  Arg Phe Trp 
    1040                 1045                 1050             


Ser Arg  Thr Gly Lys Asp Asn  Pro Lys Ser Phe Glu  Lys His Lys 
    1055                 1060                 1065             


Ile Glu  Leu Lys Pro Tyr Glu  Lys Ala Lys Phe Glu  Lys Gly Glu 
    1070                 1075                 1080             


Glu Leu  Glu Val Leu Gly Lys  Val Pro Pro Ser Ser  Asn Gln Phe 
    1085                 1090                 1095             


Gln Lys  Asn Met Gln Ile Glu  Asn Leu Ser Ile Tyr  Lys Val Lys 
    1100                 1105                 1110             


Thr Asp  Val Leu Gly Asn Lys  His Phe Ile Lys Lys  Glu Gly Asp 
    1115                 1120                 1125             


Lys Pro  Lys Leu Lys Phe 
    1130                 


<210> 552
<211> 1371
<212> PRT
<213> Streptococcus oralis


<220>
<223> Streptococcus oralis SK610

<400> 552
Met Glu Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ser Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Arg Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Ala Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Ile Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ala Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Asp Thr Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Ser Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Gly Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Val Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Thr Asp Tyr Phe Leu Glu Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Asp Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Glu Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Gln Ile Val Thr Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Gln Phe Leu His Asn Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asp Ser Lys Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp 
625                 630                 635                 640 


Ser Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Ile Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asp Gly Ile Cys Asp 
            660                 665                 670         


Lys Gln Thr Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Lys 
        675                 680                 685             


Asn Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Glu Ile Thr Gln Lys Ala Gln Val Val Gly Lys Thr Asp Asp Val 
705                 710                 715                 720 


Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Thr Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ala Leu Lys Asn Leu Ala Ser Gly Leu Asp Ser Asn Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asn Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Lys Pro Leu Asp 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Val Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Leu Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Glu Val Val Gln 
865                 870                 875                 880 


Lys Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp 
            900                 905                 910         


Glu Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Lys 
    930                 935                 940                 


Glu Val Asn Glu Lys Asp Lys Lys Asn Arg Thr Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Arg Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Leu Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Arg Ser Arg Asn  Pro Lys Glu Val Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Thr Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Ala Thr Ile Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Arg Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Pro Lys Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Asp Ile Leu Trp Glu  Thr Thr Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Val Ile Ala Tyr Ser  Ile Leu Leu Ile Ala  Asp Ile Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ala Lys Lys Leu  Lys Thr Val Lys Thr  Leu Val Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Lys Ala  Ala Phe Glu Glu Asn  Pro Ile Thr 
    1175                 1180                 1185             


Phe Leu  Glu Asn Lys Gly Tyr  His Asn Val Arg Lys  Glu Asn Ile 
    1190                 1195                 1200             


Leu Cys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Ile Val  Leu Pro Val Tyr Leu  Thr Thr Leu Leu Tyr  His Ser Lys 
    1235                 1240                 1245             


Asn Val  His Lys Leu Asp Glu  Pro Glu His Leu Glu  Tyr Ile Gln 
    1250                 1255                 1260             


Lys His  Arg Asn Glu Phe Lys  Asp Leu Leu Asn Leu  Val Ser Glu 
    1265                 1270                 1275             


Phe Ser  Gln Lys Tyr Val Leu  Ala Asp Ala Asn Leu  Glu Lys Ile 
    1280                 1285                 1290             


Gln Asn  Leu Tyr Ala Asp Asn  Glu Gln Ala Asp Ile  Glu Ile Leu 
    1295                 1300                 1305             


Ala Asn  Ser Phe Ile Asn Leu  Leu Thr Phe Thr Ala  Leu Gly Ala 
    1310                 1315                 1320             


Pro Ala  Ala Phe Lys Phe Phe  Gly Lys Asp Ile Asp  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Thr  Thr Val Ser Glu Ile  Leu Asn Ala Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1355                 1360                 1365             


Gly Glu  Asp 
    1370     


<210> 553
<211> 1140
<212> PRT
<213> Streptococcus parasanguinis


<220>
<223> Streptococcus parasanguinis F0449

<400> 553
Met Asn Gly Leu Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Lys Lys Asp Ile Gly Glu Ile Ile His Thr Asn Ser 
            20                  25                  30          


Arg Leu Phe Ser Ala Ala Thr Ala Asp Ser Asn Ile Glu Arg Arg Gly 
        35                  40                  45              


His Arg Gly Gly Lys Arg Leu Thr Arg Arg Lys Lys His Arg Ser Ile 
    50                  55                  60                  


Arg Leu His Asp Leu Phe Glu Asp Phe Gly Leu Leu Thr Asp Phe Ser 
65                  70                  75                  80  


Lys Val Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Gln Gly Leu 
                85                  90                  95      


Asp Asn Gln Leu Thr Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Ile 
            100                 105                 110         


Val Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly 
        115                 120                 125             


Gly Thr Val Ser Ser Asp Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 
    130                 135                 140                 


Leu Leu Ala Glu Gln Thr Pro Gly Gln Ile Gln Leu Asp Arg Phe Glu 
145                 150                 155                 160 


Lys Tyr Gly Gln Val Arg Gly Asp Phe Asn Val Val Glu Asn Gly Glu 
                165                 170                 175     


Lys Arg Arg Leu Ile Asn Val Phe Thr Thr Ser Ala Tyr Ser Lys Glu 
            180                 185                 190         


Ala Glu Arg Ile Leu Arg Lys Gln Gln Glu Phe Asn Lys Lys Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Glu Asp Tyr Leu Thr Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Thr Thr Lys Lys Asp Pro Glu Gly Lys Tyr Ile Thr Leu Asp Asn 
                245                 250                 255     


Ile Phe Gly Ile Leu Ile Gly Lys Cys Thr Phe Tyr Pro Asp Glu Tyr 
            260                 265                 270         


Arg Ala Ser Lys Ala Ser Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn 
        275                 280                 285             


Asp Leu Asn Asn Leu Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu 
    290                 295                 300                 


Glu Gln Lys Lys Thr Ile Ile Lys Tyr Ala Lys Thr Ala Lys Thr Leu 
305                 310                 315                 320 


Gly Ala Ser Thr Leu Leu Lys Tyr Ile Ala Lys Leu Ile Gly Ala Ser 
                325                 330                 335     


Val Asp Gln Ile His Gly Tyr Arg Ile Asp Pro Asn Lys Lys Pro Glu 
            340                 345                 350         


Met His Thr Phe Glu Thr Tyr Arg Lys Met Gln Ser Leu Glu Thr Ile 
        355                 360                 365             


Ser Val Glu Glu Leu Pro Arg Lys Val Leu Asp Glu Leu Ala His Ile 
    370                 375                 380                 


Leu Thr Leu Asn Thr Glu Arg Glu Gly Ile Glu Glu Ala Ile Asn Ala 
385                 390                 395                 400 


Thr Leu Lys Asp Thr Phe Ser Gln Asp Gln Val Leu Glu Leu Val Gln 
                405                 410                 415     


Phe Arg Lys Asn Asn Ser Ser Leu Phe Ser Lys Gly Trp His Ser Phe 
            420                 425                 430         


Ser Leu Lys Leu Met Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser 
        435                 440                 445             


Glu Glu Gln Met Thr Ile Leu Thr Arg Leu Gly Lys Gln Lys Ser Lys 
    450                 455                 460                 


Glu Thr Ser Lys Arg Thr Lys Tyr Ile Asp Glu Lys Glu Leu Thr Glu 
465                 470                 475                 480 


Glu Ile Tyr Asn Pro Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys 
                485                 490                 495     


Ile Ile Asn Glu Ala Thr Lys Lys Tyr Gly Ile Phe Asp Asn Ile Val 
            500                 505                 510         


Ile Glu Met Ala Arg Glu Asn Asn Glu Glu Asp Ala Lys Lys Glu Tyr 
        515                 520                 525             


Ile Lys Arg Gln Lys Ala Asn Leu Asp Glu Lys Asn Ala Ala Met Glu 
    530                 535                 540                 


Lys Ala Ala Phe Gln Tyr Asn Gly Lys Lys Glu Leu Pro Asp Asn Val 
545                 550                 555                 560 


Phe His Gly His Lys Glu Leu Ala Thr Lys Ile Arg Leu Trp His Gln 
                565                 570                 575     


Gln Gly Glu Lys Cys Leu Tyr Thr Gly Lys Asn Ile Pro Ile Ser Asp 
            580                 585                 590         


Leu Ile Gln Asn Gln Tyr Lys Tyr Glu Ile Asp His Ile Leu Pro Leu 
        595                 600                 605             


Ser Leu Ser Phe Asp Asp Ser Leu Ser Asn Lys Val Leu Val Leu Ala 
    610                 615                 620                 


Thr Ala Asn Gln Glu Lys Gly Gln Arg Thr Pro Phe Gln Ala Leu Asp 
625                 630                 635                 640 


Ser Met Asp Asp Ala Trp Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys 
                645                 650                 655     


Asp Ser Lys Leu Leu Gly Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu 
            660                 665                 670         


Glu Asp Ile Ser Lys Ile Glu Val Lys Gln Lys Phe Ile Glu Arg Asn 
        675                 680                 685             


Leu Val Asp Thr Arg Tyr Ser Ser Arg Val Val Leu Asn Ala Leu Gln 
    690                 695                 700                 


Asp Phe Tyr Lys Glu His Gln Phe Asp Thr Thr Ile Ser Val Val Arg 
705                 710                 715                 720 


Gly Gln Phe Thr Ser Gln Leu Arg Arg Lys Trp Gly Leu Glu Lys Ser 
                725                 730                 735     


Arg Glu Thr Tyr His His His Ala Val Asp Ala Leu Ile Ile Ala Ala 
            740                 745                 750         


Ser Ser Gln Leu Arg Leu Trp Lys Lys Gln Asn Asn Pro Leu Ile Ser 
        755                 760                 765             


Tyr Thr Glu Gly Gln Phe Val Asp Gln Val Thr Gly Glu Ile Ile Ser 
    770                 775                 780                 


Leu Ser Asp Asp Glu Tyr Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp 
785                 790                 795                 800 


His Phe Val Asp Thr Leu Lys Ser Lys Lys Phe Glu Asp Ser Ile Leu 
                805                 810                 815     


Phe Ser Tyr Gln Val Asp Ser Lys Tyr Asn Arg Lys Ile Ser Asp Ala 
            820                 825                 830         


Thr Ile Tyr Ala Thr Arg Lys Ala Lys Leu Asp Lys Glu Asn Lys Glu 
        835                 840                 845             


Tyr Thr Tyr Thr Leu Gly Lys Ile Lys Asp Ile Tyr Ala Leu Gly Thr 
    850                 855                 860                 


Lys Ser Pro Ser Lys Thr Gly Phe Tyr Lys Phe Leu Asp Leu Tyr Asn 
865                 870                 875                 880 


Lys Asp Lys Ser Gln Phe Leu Met Phe Gln Lys Asp Arg Lys Thr Trp 
                885                 890                 895     


Asp Glu Val Ile Glu Lys Ile Ile Glu Gln Tyr Arg Pro Phe Lys Glu 
            900                 905                 910         


Tyr Asp Glu Asn Gly Lys Glu Val Asp Phe Asn Pro Phe Glu Lys Tyr 
        915                 920                 925             


Arg Ile Glu Asn Gly Pro Ile Arg Lys Tyr Ser Lys Lys Gly Asn Gly 
    930                 935                 940                 


Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Leu Leu Gly Lys Phe 
945                 950                 955                 960 


Val Asp Ile Thr Pro Ser Glu Ser Lys Asn Pro Val Ala Leu Leu Ser 
                965                 970                 975     


Leu Asn Pro Trp Arg Thr Asp Val Tyr Tyr Asn Thr Glu Thr Ser Lys 
            980                 985                 990         


Tyr Glu Phe Leu Gly Leu Lys Tyr  Ala Asp Leu Cys Phe  Glu Lys Gly 
        995                 1000                 1005             


Gly Ala  Tyr Gly Ile Ser Glu  Val Lys Tyr Asn Lys  Ile Arg Glu 
    1010                 1015                 1020             


Lys Glu  Gly Ile Gly Lys Glu  Ser Glu Phe Lys Phe  Thr Leu Tyr 
    1025                 1030                 1035             


Lys Asn  Asp Leu Ile Leu Ile  Lys Asp Thr Glu Thr  Asn Cys Gln 
    1040                 1045                 1050             


Gln Ile  Phe Arg Phe Trp Ser  Arg Thr Gly Lys Asp  Asn Pro Lys 
    1055                 1060                 1065             


Ser Phe  Glu Lys His Lys Ile  Glu Leu Lys Pro Tyr  Glu Lys Ala 
    1070                 1075                 1080             


Arg Phe  Glu Lys Gly Glu Glu  Leu Glu Val Leu Gly  Lys Val Pro 
    1085                 1090                 1095             


Pro Ser  Ser Asn Gln Leu Gln  Lys Asn Met Gln Ile  Glu Asn Leu 
    1100                 1105                 1110             


Ser Ile  Tyr Lys Val Lys Thr  Asp Val Leu Gly Asn  Lys His Phe 
    1115                 1120                 1125             


Ile Lys  Lys Glu Gly Glu Glu  Pro Lys Leu Lys Phe  
    1130                 1135                 1140 


<210> 554
<211> 1130
<212> PRT
<213> Streptococcus pasteurianus

<400> 554
Met Thr Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Glu Ala Lys Thr Gly Lys Val Val His Ala Asn 
            20                  25                  30          


Ser Arg Leu Phe Ser Ala Ala Asn Ala Glu Asn Asn Ala Glu Arg Arg 
        35                  40                  45              


Gly Phe Arg Gly Ser Arg Arg Leu Asn Arg Arg Lys Lys His Arg Val 
    50                  55                  60                  


Lys Arg Val Arg Asp Leu Phe Glu Lys Tyr Gly Ile Val Thr Asp Phe 
65                  70                  75                  80  


Arg Asn Leu Asn Leu Asn Pro Tyr Glu Leu Arg Val Lys Gly Leu Thr 
                85                  90                  95      


Glu Gln Leu Lys Asn Glu Glu Leu Phe Ala Ala Leu Arg Thr Ile Ser 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Thr 
        115                 120                 125             


Gly Ser Thr Asp Tyr Ala Lys Ser Ile Asp Glu Asn Arg Arg Leu Leu 
    130                 135                 140                 


Lys Asn Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Leu Glu Lys Tyr 
145                 150                 155                 160 


Gly Gln Leu Arg Gly Asn Phe Thr Val Tyr Asp Glu Asn Gly Glu Ala 
                165                 170                 175     


His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Glu Lys Glu Ala 
            180                 185                 190         


Arg Lys Ile Leu Glu Thr Gln Ala Asp Tyr Asn Lys Lys Ile Thr Ala 
        195                 200                 205             


Glu Phe Ile Asp Asp Tyr Val Glu Ile Leu Thr Gln Lys Arg Lys Tyr 
    210                 215                 220                 


Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg Phe 
225                 230                 235                 240 


Arg Thr Asp Gly Thr Thr Leu Glu Asn Ile Phe Gly Ile Leu Ile Gly 
                245                 250                 255     


Lys Cys Asn Phe Tyr Pro Asp Glu Tyr Arg Ala Ser Lys Ala Ser Tyr 
            260                 265                 270         


Thr Ala Gln Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Lys Val 
        275                 280                 285             


Ser Thr Glu Thr Gly Lys Leu Ser Thr Glu Gln Lys Glu Ser Leu Val 
    290                 295                 300                 


Glu Phe Ala Lys Asn Thr Ala Thr Leu Gly Pro Ala Lys Leu Leu Lys 
305                 310                 315                 320 


Glu Ile Ala Lys Ile Leu Asp Cys Lys Val Asp Glu Ile Lys Gly Tyr 
                325                 330                 335     


Arg Glu Asp Asp Lys Gly Lys Pro Asp Leu His Thr Phe Glu Pro Tyr 
            340                 345                 350         


Arg Lys Leu Lys Phe Asn Leu Glu Ser Ile Asn Ile Asp Asp Leu Ser 
        355                 360                 365             


Arg Glu Val Ile Asp Lys Leu Ala Asp Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Asp Ala Ile Lys Arg Asn Leu Pro Asn Gln Phe 
385                 390                 395                 400 


Thr Glu Glu Gln Ile Ser Glu Ile Ile Lys Val Arg Lys Ser Gln Ser 
                405                 410                 415     


Thr Ala Phe Asn Lys Gly Trp His Ser Phe Ser Ala Lys Leu Met Asn 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Ala Thr Ser Asp Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Glu Lys Phe Lys Val Asn Lys Lys Ser Ser Lys Asn 
    450                 455                 460                 


Thr Lys Thr Ile Asp Glu Lys Glu Val Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Thr Ile Lys Ile Ile Asn Ala Ala 
                485                 490                 495     


Val Lys Lys Tyr Gly Asp Phe Asp Lys Ile Val Ile Glu Met Pro Arg 
            500                 505                 510         


Asp Lys Asn Ala Asp Asp Glu Lys Lys Phe Ile Asp Lys Arg Asn Lys 
        515                 520                 525             


Glu Asn Lys Lys Glu Lys Asp Asp Ala Leu Lys Arg Ala Ala Tyr Leu 
    530                 535                 540                 


Tyr Asn Ser Ser Asp Lys Leu Pro Asp Glu Val Phe His Gly Asn Lys 
545                 550                 555                 560 


Gln Leu Glu Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Ser Gly Lys Pro Ile Ser Ile Gln Glu Leu Val His Asn Ser 
            580                 585                 590         


Asn Asn Phe Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Trp Thr Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Lys Thr Pro Tyr Gln Val Ile Asp Ser Met Asp Ala Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Met Lys Asp Tyr Val Leu Lys Gln Lys Gly Leu 
                645                 650                 655     


Gly Lys Lys Lys Arg Asp Tyr Leu Leu Thr Thr Glu Asn Ile Asp Lys 
            660                 665                 670         


Ile Glu Val Lys Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ser Leu Gln Ser Ala Leu Arg Glu 
    690                 695                 700                 


Leu Gly Lys Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg Lys Trp Lys Ile Asp Lys Ser Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Lys 
            740                 745                 750         


Leu Trp Glu Lys Gln Asp Asn Pro Met Phe Val Asp Tyr Gly Lys Asn 
        755                 760                 765             


Gln Val Val Asp Lys Gln Thr Gly Glu Ile Leu Ser Val Ser Asp Asp 
    770                 775                 780                 


Glu Tyr Lys Glu Leu Val Phe Gln Pro Pro Tyr Gln Gly Phe Val Asn 
785                 790                 795                 800 


Thr Ile Ser Ser Lys Gly Phe Glu Asp Glu Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Tyr Asn Arg Lys Val Ser Asp Ala Thr Ile Tyr Ser 
            820                 825                 830         


Thr Arg Lys Ala Lys Ile Gly Lys Asp Lys Lys Glu Glu Thr Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gln Asn Gly Phe Asp Thr Phe 
    850                 855                 860                 


Ile Lys Lys Tyr Asn Lys Asp Lys Thr Gln Phe Leu Met Tyr Gln Lys 
865                 870                 875                 880 


Asp Ser Leu Thr Trp Glu Asn Val Ile Glu Val Ile Leu Arg Asp Tyr 
                885                 890                 895     


Pro Thr Thr Lys Lys Ser Glu Asp Gly Lys Asn Asp Val Lys Cys Asn 
            900                 905                 910         


Pro Phe Glu Glu Tyr Arg Arg Glu Asn Gly Leu Ile Cys Lys Tyr Ser 
        915                 920                 925             


Lys Lys Gly Lys Gly Thr Pro Ile Lys Ser Leu Lys Tyr Tyr Asp Lys 
    930                 935                 940                 


Lys Leu Gly Asn Cys Ile Asp Ile Thr Pro Glu Glu Ser Arg Asn Lys 
945                 950                 955                 960 


Val Ile Leu Gln Ser Ile Asn Pro Trp Arg Ala Asp Val Tyr Phe Asn 
                965                 970                 975     


Pro Glu Thr Leu Lys Tyr Glu Leu Met Gly Leu Lys Tyr Ser Asp Leu 
            980                 985                 990         


Ser Phe Glu Lys Gly Thr Gly Asn  Tyr His Ile Ser Gln  Glu Lys Tyr 
        995                 1000                 1005             


Asp Ala  Ile Lys Glu Lys Glu  Gly Ile Gly Lys Lys  Ser Glu Phe 
    1010                 1015                 1020             


Lys Phe  Thr Leu Tyr Arg Asn  Asp Leu Ile Leu Ile  Lys Asp Ile 
    1025                 1030                 1035             


Ala Ser  Gly Glu Gln Glu Ile  Tyr Arg Phe Leu Ser  Arg Thr Met 
    1040                 1045                 1050             


Pro Asn  Val Asn His Tyr Val  Glu Leu Lys Pro Tyr  Asp Lys Glu 
    1055                 1060                 1065             


Lys Phe  Asp Asn Val Gln Glu  Leu Val Glu Ala Leu  Gly Glu Ala 
    1070                 1075                 1080             


Asp Lys  Val Gly Arg Cys Ile  Lys Gly Leu Asn Lys  Pro Asn Ile 
    1085                 1090                 1095             


Ser Ile  Tyr Lys Val Arg Thr  Asp Val Leu Gly Asn  Lys Tyr Phe 
    1100                 1105                 1110             


Val Lys  Lys Lys Gly Asp Lys  Pro Lys Leu Asp Phe  Lys Asn Asn 
    1115                 1120                 1125             


Lys Lys  
    1130 


<210> 555
<211> 1374
<212> PRT
<213> Streptococcus pseudoporcinus


<220>
<223> Streptococcus pseudoporcinus LQ 940-04

<400> 555
Met Lys Lys Arg Tyr Ser Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Ile Asn Glu Asp Tyr Lys Val Pro Ala Lys 
            20                  25                  30          


Lys Met Thr Val Phe Gly Asn Thr Asp Arg Lys Thr Ile Lys Lys Asn 
        35                  40                  45              


Leu Leu Gly Thr Val Leu Phe Asp Ser Gly Glu Thr Ala Gln Ala Arg 
    50                  55                  60                  


Arg Leu Lys Arg Thr Asn Arg Arg Arg Tyr Thr Arg Arg Arg Tyr Arg 
65                  70                  75                  80  


Leu Cys Gln Leu Gln Asn Ile Phe Ala Thr Glu Met Val Lys Val Asp 
                85                  90                  95      


Asp Thr Phe Phe Gln Arg Leu Ser Glu Ser Phe Phe Tyr Tyr Gln Asp 
            100                 105                 110         


Lys Ala Phe Asp Lys His Pro Ile Phe Gly Asn Ser Lys Glu Glu Arg 
        115                 120                 125             


Ala Tyr His Lys Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Asp Leu 
    130                 135                 140                 


Ala Asp Arg Asp Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu 
145                 150                 155                 160 


Ser His Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Leu 
                165                 170                 175     


Asn Ser Glu Asn Thr Asp Val Gln Lys Leu Phe Ile Ala Leu Val Thr 
            180                 185                 190         


Val Tyr Asn Leu Leu Phe Glu Glu Glu Pro Ile Ala Gly Glu Thr Cys 
        195                 200                 205             


Asp Ala Lys Ala Leu Leu Thr Ala Lys Thr Ser Lys Ser Lys Arg Leu 
    210                 215                 220                 


Glu Ser Leu Ile Ser Glu Phe Pro Gly Gln Lys Lys Asn Gly Leu Phe 
225                 230                 235                 240 


Gly Asn Leu Leu Ala Leu Ala Leu Gly Leu Arg Pro Asn Phe Lys Ser 
                245                 250                 255     


Asn Phe Gly Leu Ser Glu Asp Ala Lys Leu Gln Ile Thr Lys Asp Thr 
            260                 265                 270         


Tyr Glu Glu Glu Leu Asp Asn Leu Leu Ala Glu Ile Gly Asp His Tyr 
        275                 280                 285             


Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu 
    290                 295                 300                 


Ser Asp Ile Leu Thr Leu Ser Asp Glu Asn Thr Arg Ala Pro Leu Ser 
305                 310                 315                 320 


Ala Ser Met Ile Lys Arg Tyr Glu Glu His Gln Glu Asp Leu Ala Leu 
                325                 330                 335     


Leu Lys Lys Leu Val Lys Glu Gln Met Pro Glu Lys Tyr Trp Glu Ile 
            340                 345                 350         


Phe Ser Asn Ala Lys Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Gly Lys 
        355                 360                 365             


Val Ser Gln Glu Asp Phe Tyr Arg Tyr Ile Lys Pro Ile Leu Ser Arg 
    370                 375                 380                 


Leu Lys Gly Gly Asp Glu Phe Leu Ala Lys Ile Asp Arg Asp Asp Phe 
385                 390                 395                 400 


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile 
                405                 410                 415     


His Leu Lys Glu Leu His Ala Ile Leu Arg Arg Gln Glu Lys Tyr Tyr 
            420                 425                 430         


Pro Phe Leu Ala Glu Gln Lys Glu Lys Ile Glu Gln Leu Leu Cys Phe 
        435                 440                 445             


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Gly Gly Asn Ser Ser 
    450                 455                 460                 


Phe Ala Trp Leu Lys Arg Arg Ser Asp Glu Pro Ile Thr Pro Trp Asn 
465                 470                 475                 480 


Phe Lys Asp Val Val Asp Glu Glu Ala Ser Ala Gln Ala Phe Ile Glu 
                485                 490                 495     


Gly Met Thr Asn Tyr Asp Thr Tyr Leu Pro Glu Glu Lys Val Leu Pro 
            500                 505                 510         


Lys His Ser Pro Leu Tyr Glu Met Phe Thr Val Tyr Asn Glu Leu Thr 
        515                 520                 525             


Lys Val Lys Tyr Ile Ala Glu Asn Met Thr Lys Pro Leu Tyr Leu Ser 
    530                 535                 540                 


Ala Glu Gln Lys Glu Ala Ile Ile Asp His Leu Phe Lys Gln Thr Arg 
545                 550                 555                 560 


Lys Val Thr Val Lys Asp Leu Lys Glu Lys Tyr Phe Ser Gln Ile Glu 
                565                 570                 575     


Gly Leu Glu Asn Val Asp Val Thr Gly Val Glu Gly Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr Asn Asp Leu Leu Lys Ile Ile Lys Asp Lys Ala 
        595                 600                 605             


Phe Leu Asp Asp Glu Ala Asn Ala Glu Ile Leu Glu Glu Ile Val Leu 
    610                 615                 620                 


Ile Leu Thr Leu Phe Gln Asp Glu Lys Leu Ile Glu Lys Arg Leu Ala 
625                 630                 635                 640 


Lys Tyr Ala Asn Leu Phe Glu Lys Ser Val Leu Lys Lys Leu Arg Lys 
                645                 650                 655     


Arg His Tyr Arg Gly Trp Gly Arg Leu Ser Arg Gln Leu Ile Asp Gly 
            660                 665                 670         


Met Lys Asp Lys Ala Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ala 
        675                 680                 685             


Asp Asp Phe Ala Asn Arg Asn Phe Ile Gln Leu Ile Asn Asp Ser Ser 
    690                 695                 700                 


Leu Asp Phe Glu Lys Leu Ile Asp Asp Ala Gln Lys Lys Ala Ile Lys 
705                 710                 715                 720 


Arg Glu Ser Leu Thr Glu Ala Val Ala Asn Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Val Val Asp Glu Ile Val 
            740                 745                 750         


Lys Val Met Gly His Asn Pro Asp Asn Ile Val Ile Glu Met Ser Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Ala Gln Gly Leu Lys Asn Ala Arg Gln Arg Leu 
    770                 775                 780                 


Lys Lys Ile Lys Glu Val His Lys Lys Thr Gly Ser Arg Ile Leu Glu 
785                 790                 795                 800 


Asp Asn Ser Glu Arg Ile Thr Asn Leu Thr Leu Gln Asp Asn Arg Leu 
                805                 810                 815     


Tyr Leu Tyr Leu Leu Gln Asp Gly Lys Asp Met Tyr Thr Gly Gln Asp 
            820                 825                 830         


Leu Asp Ile Asn Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ser Phe Ile Lys Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Thr 
    850                 855                 860                 


Gln Lys Ala Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Glu Val 
865                 870                 875                 880 


Val Arg Asp Met Lys Asp Arg Val Trp Arg Arg Gln Leu Ala Asn Gly 
                885                 890                 895     


Ala Ile Ser Arg Gln Lys Phe Asp His Leu Thr Lys Ala Glu Arg Gly 
            900                 905                 910         


Gly Leu Ala Asp Ser Asp Lys Ala Arg Phe Leu Arg Arg Gln Leu Val 
        915                 920                 925             


Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Leu Leu Asp Ser Arg 
    930                 935                 940                 


Phe Asn Ser Lys Ser Asn Gln Asn Lys Lys Leu Ala Arg Asn Val Lys 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ser Lys Ile Val Ser Asp Phe Arg Lys Asp Phe 
                965                 970                 975     


Gly Leu Tyr Lys Leu Arg Glu Val Asn Asn Tyr His His Ala His Asp 
            980                 985                 990         


Ala Tyr Leu Asn Ala Val Val Gly  Thr Ala Leu Leu Lys  Lys Tyr Pro 
        995                 1000                 1005             


Lys Leu  Glu Ala Glu Phe Val  Tyr Gly Asp Tyr Lys  His Phe Asp 
    1010                 1015                 1020             


Leu Val  Lys Leu Ile Ser Lys  Ser Asp Pro Ser Leu  Gly Lys Ala 
    1025                 1030                 1035             


Thr Ala  Lys Val Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1040                 1045                 1050             


Glu Glu  Leu Ser Leu Ala Asp  Gly Thr Leu Met Lys  Arg Pro Val 
    1055                 1060                 1065             


Ile Glu  Thr Asn Thr Glu Thr  Gly Glu Val Val Trp  Asp Lys Val 
    1070                 1075                 1080             


Lys Asp  Phe Lys Thr Ile Arg  Lys Val Leu Ser Tyr  Pro Gln Val 
    1085                 1090                 1095             


Asn Ile  Val Lys Lys Thr Glu  Ile Gln Ser Gly Ala  Phe Ser Lys 
    1100                 1105                 1110             


Glu Ser  Val Leu Ser Lys Gly  Asn Ser Asp Lys Leu  Ile Glu Arg 
    1115                 1120                 1125             


Lys Lys  Gly Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1130                 1135                 1140             


Asn Thr  Ala Tyr Ser Ile Phe  Val Val Ala Lys Val  Ala Lys Arg 
    1145                 1150                 1155             


Lys Ala  Gln Lys Leu Lys Thr  Val Lys Glu Ile Val  Gly Ile Thr 
    1160                 1165                 1170             


Ile Met  Glu Gln Ala Glu Tyr  Glu Lys Asp Asn Ile  Ala Phe Leu 
    1175                 1180                 1185             


Glu Lys  Lys Gly Tyr Gln Asp  Ile Gln Glu Lys Leu  Leu Ile Lys 
    1190                 1195                 1200             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg 
    1205                 1210                 1215             


Leu Leu  Ala Ser Ala Asn Glu  Phe Gln Lys Gly Asn  Glu Leu Ala 
    1220                 1225                 1230             


Leu Ser  Gly Lys Tyr Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr 
    1235                 1240                 1245             


Asp Lys  Leu Ser Ser Lys Ile  Glu Ser Glu Gln Gln  Lys Lys Leu 
    1250                 1255                 1260             


Phe Val  Glu Gln His Leu His  Tyr Phe Asp Glu Ile  Leu Asp Ile 
    1265                 1270                 1275             


Val Val  Lys His Ala Thr Cys  Tyr Ile Lys Ala Glu  Asn Asn Leu 
    1280                 1285                 1290             


Lys Lys  Ile Ile Ser Leu Tyr  Lys Lys Lys Glu Ala  Tyr Ser Ile 
    1295                 1300                 1305             


Asn Glu  Gln Ala Leu Asn Met  Leu Asn Leu Phe Ile  Phe Thr Ser 
    1310                 1315                 1320             


Leu Gly  Ala Pro Ser Thr Phe  Val Phe Phe Asp Glu  Thr Ile Asp 
    1325                 1330                 1335             


Arg Lys  Arg Tyr Thr Thr Ser  Ser Asp Val Leu Asn  Gly Ile Leu 
    1340                 1345                 1350             


Ile Gln  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1355                 1360                 1365             


Ser Arg  Phe Gly Gly Asp 
    1370                 


<210> 556
<211> 1368
<212> PRT
<213> Streptococcus pyogenes


<220>
<223> Streptococcus pyogenes MGAS10270

<400> 556
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Leu Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 557
<211> 1371
<212> PRT
<213> Streptococcus pyogenes

<400> 557
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Thr Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Ile Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Ile Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Ser  Asp 
    1370     


<210> 558
<211> 1367
<212> PRT
<213> Streptococcus pyogenes

<400> 558
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Gly Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Ile Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Ala Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Gly Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210> 559
<211> 1368
<212> PRT
<213> Streptococcus sp.

<400> 559
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Ile Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Leu Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Thr Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Phe Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 560
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 560
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Leu 
            20                  25                  30          


Lys Gly Leu Gly Asn Thr Asp Arg His Gly Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Val Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Thr Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 561
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 561
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 562
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 562
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asn Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Val Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Phe Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 563
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 563
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Ile Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Val Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Leu Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Thr Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Phe Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 564
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 564
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Ile Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Leu Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Thr Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Lys Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Ile Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Val Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Val Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Cys Phe Asp Thr Thr  Ile Gly Arg Asn Arg  Tyr Lys Ser 
    1325                 1330                 1335             


Ile Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 565
<211> 1368
<212> PRT
<213> Streptococcus pyogenes


<220>
<223> Streptococcus pyogenes M1 GAS

<400> 565
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 566
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 566
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Leu 
            20                  25                  30          


Lys Gly Leu Gly Asn Thr Asp Arg His Gly Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Val Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Thr Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 567
<211> 1370
<212> PRT
<213> Streptococcus ratti


<220>
<223> Streptococcus ratti FA-1 = DSM 20564

<400> 567
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Asn Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Leu Leu 
65                  70                  75                  80  


Tyr Leu Gln Asp Ile Phe Ser Asp Glu Met Asn Lys Val Asp Glu Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Ser Glu Asp Lys Arg 
            100                 105                 110         


Gly Asp His His Pro Ile Phe Gly Asn Val Val Asp Glu Val Lys Tyr 
        115                 120                 125             


His Glu Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Thr Pro Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Asp Asp Pro Lys Leu Asp 
                165                 170                 175     


Val Lys Asn Thr Asp Ser Gln Glu Leu Phe Ser Gln Phe Leu Thr Ala 
            180                 185                 190         


Tyr Asp Val Thr Gln Glu Asp Ser His Leu Ala Asp Val Lys Ile Asn 
        195                 200                 205             


Ile Ser Asp Ile Ile Thr Glu Lys Met Asn Lys Ser Arg Lys Val Glu 
    210                 215                 220                 


Ala Leu Leu Phe His Phe Pro Ser Gln Lys Lys Asn Ser Phe Phe Gly 
225                 230                 235                 240 


Asn Leu Val Ser Leu Val Phe Gly Leu Leu Pro Asn Phe Lys Thr Asn 
                245                 250                 255     


Phe Asn Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Tyr Thr 
        275                 280                 285             


Asp Val Phe Val Ala Ala Arg Lys Leu Tyr Asp Ser Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Asn Asp Leu Ser Thr Lys Ala Ile Leu Ser Ala 
305                 310                 315                 320 


Ser Met Val Arg Arg Tyr Glu Glu His Asn Lys Asp Leu Ala Lys Leu 
                325                 330                 335     


Lys Ala Phe Val Lys Ala Asn Phe Thr His Asp Val Phe Lys Glu Val 
            340                 345                 350         


Phe Ser Asp Ala Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Gly Lys 
        355                 360                 365             


Thr Ser Gln Glu Asp Phe Tyr Lys Tyr Val Lys Asn Leu Ile Gly Lys 
    370                 375                 380                 


Val Asp Gly Ser Ala Asp Phe Ile Glu Lys Ile Asp Arg Glu Asp Phe 
385                 390                 395                 400 


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val 
                405                 410                 415     


His Leu Ala Glu Met Lys Ala Ile Leu Arg Arg Gln Gly Glu Tyr Tyr 
            420                 425                 430         


Pro Phe Leu Lys Glu His Ala Glu Lys Ile Gln Gln Ile Leu Thr Phe 
        435                 440                 445             


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asp Arg His Gly His Ser Asp 
    450                 455                 460                 


Phe Ala Trp Ala Ser Phe Asn Ser Glu Glu Lys Val Thr Pro Trp Asn 
465                 470                 475                 480 


Phe Glu Glu Ile Ile Asp Lys Asn Lys Ser Ala Gln Ala Phe Ile Glu 
                485                 490                 495     


Arg Met Thr Asn Gln Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro 
            500                 505                 510         


Lys His Ser Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr 
        515                 520                 525             


Lys Ile Lys Tyr Val Thr Glu Thr Gly Thr Ala Lys Phe Phe Asp Ala 
    530                 535                 540                 


Asn Leu Lys Gln Glu Ile Phe Asp Gly Leu Phe Lys Lys Glu Arg Lys 
545                 550                 555                 560 


Val Thr Lys Arg Lys Leu Leu Thr Phe Leu Glu Lys Asn Phe Asp Glu 
                565                 570                 575     


Phe Arg Ile Val Asp Ile Gln Gly Leu Asp Lys Glu Thr Glu Thr Phe 
            580                 585                 590         


Asn Ala Ser Tyr Gly Ile Tyr Gln Asp Leu Leu Lys Ile Ile Lys Asp 
        595                 600                 605             


Lys Ala Phe Met Asp Asp Ser Glu Asn Ala Asp Ile Leu Glu Asp Ile 
    610                 615                 620                 


Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gln Arg 
625                 630                 635                 640 


Leu Ala Lys Tyr Ala Asp Leu Phe Asp Lys Lys Val Ile Asp Asn Leu 
                645                 650                 655     


Ala Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu 
            660                 665                 670         


Asn Gly Ile Arg Asp Lys Arg Ser Arg Lys Thr Ile Met Asp Tyr Leu 
        675                 680                 685             


Val Asp Asp Gly Arg Ser Asn Arg Asn Leu Met Gln Leu Ile Thr Asp 
    690                 695                 700                 


Asp Asn Leu Thr Phe Lys Asp Glu Ile Ala Lys Ala Gln Tyr Ser Asp 
705                 710                 715                 720 


Asn Ser Asp Asp Leu His Gln Val Val Gln Asp Leu Ala Gly Ser Pro 
                725                 730                 735     


Ala Ile Lys Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu 
            740                 745                 750         


Val Lys Val Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala 
        755                 760                 765             


Arg Glu Asn Gln Thr Thr Ala Lys Gly Arg Arg Asn Ser Gln Gln Arg 
    770                 775                 780                 


Tyr Lys Arg Leu Glu Glu Ala Ile Lys Asn Leu Asp Arg Asp Leu Asn 
785                 790                 795                 800 


Tyr Lys Ile Leu Lys Glu His Pro Thr Asp Asn Gln Ala Leu Gln Asn 
                805                 810                 815     


Asp Arg Leu Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr 
            820                 825                 830         


Gly Glu Ser Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Ile Asp His 
        835                 840                 845             


Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val 
    850                 855                 860                 


Leu Val Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser 
865                 870                 875                 880 


Glu Asp Val Val Asn Arg Met Arg Pro Phe Trp Asn Lys Leu Leu Asn 
                885                 890                 895     


Cys Gly Leu Ile Ser Gln Arg Lys Tyr Ser Asn Leu Thr Lys Lys Glu 
            900                 905                 910         


Leu Thr Pro Asn Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu His Phe 
    930                 935                 940                 


Asn Lys Glu Phe Asp Glu Asp Lys Lys Arg Ile Arg Lys Val Lys Val 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu 
                965                 970                 975     


Leu Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Leu Leu Met Lys  Tyr Pro Lys 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Glu Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Arg  Glu Arg Lys Thr Ala  Thr Gln Arg Met Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Met Phe Lys  Ser Lys Val Lys Leu  Ala Asp Glu 
    1040                 1045                 1050             


Arg Ile  Ile Glu Arg Pro Met  Ile Glu Val Asn Asp  Glu Thr Gly 
    1055                 1060                 1065             


Glu Ile  Ala Trp Asp Lys Thr  Lys His Ile Ala Thr  Val Lys Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Ile  Asn Ile Val Lys Lys  Val Glu Glu 
    1085                 1090                 1095             


Gln Thr  Gly Gly Leu Thr Asn  Glu Thr Ile Tyr Pro  Arg Gly Ser 
    1100                 1105                 1110             


Phe Asp  Lys Leu Leu Asn Arg  Lys Asn Thr Leu Glu  Ala Ser Lys 
    1115                 1120                 1125             


Tyr Gly  Gly Phe Gly Ser Pro  Thr Val Ala Tyr Cys  Val Leu Val 
    1130                 1135                 1140             


Val Ala  Asp Ser Lys Asn Glu  Asn Gly Lys Val Lys  Lys Leu Lys 
    1145                 1150                 1155             


Leu Gly  Ser Glu Leu Leu Gly  Ile Thr Ile Leu Glu  Lys Asn Asp 
    1160                 1165                 1170             


Phe Glu  Asn Asn Ser Leu Asp  Phe Leu Ser Arg Lys  Gly Tyr Gln 
    1175                 1180                 1185             


Gly Val  Gln Glu Lys Lys Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Phe Gln Asp Gly Ser  Arg Arg Met Leu Ser  Ser Val Met 
    1205                 1210                 1215             


Ala Asn  Asp Asn Lys Arg Gly  Asp Leu Gln Lys Ala  Asn Glu Met 
    1220                 1225                 1230             


Ile Leu  Pro Ala Tyr Leu Val  Lys Leu Leu Tyr His  Ala Lys His 
    1235                 1240                 1245             


Ile Asn  Ser Val Gly Glu Pro  Ala His Lys Asn Tyr  Ile Asn Glu 
    1250                 1255                 1260             


His Cys  Ser Glu Phe Gln Asp  Leu Leu Asn Tyr Ile  Arg Gln Phe 
    1265                 1270                 1275             


Ala Asp  Lys Phe Val Asp Val  Asp Lys Asn Leu Ser  Lys Ile Arg 
    1280                 1285                 1290             


Ser Leu  Ser Lys Ser Met Ala  Glu Tyr Ser Val Ser  Glu Ile Cys 
    1295                 1300                 1305             


Ser Ser  Phe Val Asn Leu Leu  Thr Leu Thr Ala Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Asp  Phe Lys Phe Phe Gly  Thr Thr Ile Pro Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Gly Ser  Pro Gln Ser Ile Leu  Ser Ala Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210> 568
<211> 1127
<212> PRT
<213> Streptococcus salivarius

<400> 568
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Val Glu Arg Arg Ile 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn His Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Asn Val Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Lys Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Glu Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ala Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Ser Tyr Leu Gln Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Thr Thr Lys Lys Asp Ser Glu Asp Glu Tyr Ile Thr Leu Asp Asn 
                245                 250                 255     


Ile Phe Gly Ile Leu Ile Gly Lys Cys Thr Phe Tyr Pro Glu Glu Tyr 
            260                 265                 270         


Arg Ala Ala Lys Ala Ser Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn 
        275                 280                 285             


Asp Leu Asn Asn Leu Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu 
    290                 295                 300                 


Glu Gln Lys Asn Gln Ile Ile Thr Asn Val Lys Asn Glu Lys Ala Met 
305                 310                 315                 320 


Gly Pro Ala Lys Leu Phe Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp 
                325                 330                 335     


Val Ala Asp Ile Lys Gly Tyr Arg Ile Asp Lys Ser Asp Lys Ala Glu 
            340                 345                 350         


Ile His Thr Phe Glu Ala Tyr Arg Lys Met Lys Thr Leu Ala Thr Ile 
        355                 360                 365             


Asp Ile Glu Gln Met Glu Arg Glu Asn Leu Asp Lys Leu Ala Tyr Val 
    370                 375                 380                 


Leu Thr Leu Asn Thr Glu Lys Glu Gly Ile Gln Glu Ala Leu Glu His 
385                 390                 395                 400 


Glu Phe Ala Asp Gly Thr Phe Ser Gln Glu Gln Ile Asp Glu Leu Val 
                405                 410                 415     


Gln Phe Arg Lys Ala Asn Ser Ser Ile Phe Gly Lys Gly Trp His Ser 
            420                 425                 430         


Phe Ser Val Lys Leu Met Met Glu Leu Ile Pro Glu Leu Tyr Ala Thr 
        435                 440                 445             


Ser Glu Glu Gln Met Thr Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr 
    450                 455                 460                 


Thr Ser Ser Ser Asn Lys Thr Lys Tyr Ile Asp Glu Lys Gln Leu Thr 
465                 470                 475                 480 


Glu Glu Ile Tyr Asn Pro Val Ala Ala Lys Ser Val Arg Gln Ala Ile 
                485                 490                 495     


Lys Ile Val Asn Ala Ala Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile 
            500                 505                 510         


Val Ile Glu Met Ala Arg Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala 
        515                 520                 525             


Ile Gln Lys Ile Gln Lys Ala Asn Lys Asp Glu Lys Asp Ala Ala Met 
    530                 535                 540                 


Leu Lys Ala Ala Asn Gln Tyr Asn Gly Lys Ala Glu Leu Pro His Ser 
545                 550                 555                 560 


Val Phe His Gly His Lys Gln Leu Ala Thr Lys Ile Arg Leu Trp His 
                565                 570                 575     


Gln Gln Gly Glu Arg Cys Leu Tyr Thr Gly Lys Thr Ile Ser Ile His 
            580                 585                 590         


Asp Leu Ile Asn Asn Ser Asn Gln Phe Glu Ile Asp His Ile Leu Pro 
        595                 600                 605             


Leu Ser Ile Thr Phe Asp Asp Ser Leu Ala Asn Lys Val Leu Val Tyr 
    610                 615                 620                 


Ala Thr Ala Asn Gln Glu Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu 
625                 630                 635                 640 


Asp Ser Met Asp Asp Ala Trp Ser Phe Arg Glu Leu Lys Ala Phe Val 
                645                 650                 655     


Arg Asp Ser Lys Ala Leu Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr 
            660                 665                 670         


Glu Glu Asp Ile Ser Lys Phe Asp Val Arg Lys Lys Phe Ile Glu Arg 
        675                 680                 685             


Asn Leu Val Asp Thr Arg Tyr Ala Ser Arg Val Val Leu Asn Ala Leu 
    690                 695                 700                 


Gln Glu His Phe Arg Val His Lys Thr Asp Thr Lys Val Ser Val Val 
705                 710                 715                 720 


Arg Gly Gln Phe Thr Ser Gln Leu Arg Arg His Trp Gly Ile Glu Lys 
                725                 730                 735     


Thr Arg Asp Thr Tyr His His His Ala Val Asp Ala Leu Ile Ile Ala 
            740                 745                 750         


Ala Ser Ser Gln Leu Asn Leu Trp Lys Lys Gln Lys Asn Thr Leu Val 
        755                 760                 765             


Ser Tyr Ser Glu Asp Gln Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile 
    770                 775                 780                 


Ser Asp Asp Glu Tyr Lys Glu Ser Val Phe Lys Ala Pro Tyr Gln His 
785                 790                 795                 800 


Phe Val Asp Thr Leu Lys Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe 
                805                 810                 815     


Ser Tyr Gln Val Asp Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr 
            820                 825                 830         


Ile Tyr Ala Thr Arg Gln Ala Lys Val Gly Lys Asp Lys Lys Asp Glu 
        835                 840                 845             


Thr Tyr Val Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gln Thr Gly Tyr 
    850                 855                 860                 


Asp Ala Phe Ile Lys Ile Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met 
865                 870                 875                 880 


Tyr Arg His Asp Pro Gln Thr Phe Glu Lys Val Ile Glu Pro Ile Leu 
                885                 890                 895     


Glu Asn Tyr Pro Asn Lys Glu Leu Asn Glu Lys Gly Lys Glu Val Pro 
            900                 905                 910         


Cys Asn Pro Phe Leu Lys Tyr Lys Glu Asp His Gly Tyr Ile Arg Lys 
        915                 920                 925             


Tyr Ser Lys Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr 
    930                 935                 940                 


Asp Ser Lys Leu Gly Asn His Ile Asp Ile Thr Pro Lys Asn Ser Asn 
945                 950                 955                 960 


Asn Lys Val Val Leu Gln Ser Val Ser Pro Trp Arg Ala Asp Val Tyr 
                965                 970                 975     


Phe Asn Lys Thr Thr Gly Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala 
            980                 985                 990         


Asp Leu Lys Phe Glu Lys Gly Thr  Gly Thr Tyr Lys Ile  Ser Glu Glu 
        995                 1000                 1005             


Lys Tyr  Asn Asp Ile Lys Ile  Lys Glu Gly Val Asp  Ser Asp Ser 
    1010                 1015                 1020             


Glu Phe  Lys Phe Thr Leu Tyr  Lys Asn Asp Leu Leu  Leu Ile Lys 
    1025                 1030                 1035             


Asp Thr  Glu Thr Lys Glu Gln  Gln Leu Phe Arg Phe  Leu Ser Arg 
    1040                 1045                 1050             


Thr Met  Pro Asn Val Lys His  Tyr Val Glu Leu Lys  Pro Tyr Asp 
    1055                 1060                 1065             


Lys Gln  Lys Phe Asp Asp Asn  Glu Glu Leu Ile Lys  Ile Leu Gly 
    1070                 1075                 1080             


Ile Val  Ala Lys Gly Gly Gln  Cys Lys Lys Gly Val  Ser Lys Pro 
    1085                 1090                 1095             


Asn Ile  Ser Ile Tyr Lys Ile  Arg Thr Asp Val Leu  Gly Asn Gln 
    1100                 1105                 1110             


His Ile  Ile Lys Asn Glu Gly  Asp Lys Pro Lys Leu  Asp Phe 
    1115                 1120                 1125         


<210> 569
<211> 1385
<212> PRT
<213> Streptococcus salivarius


<220>
<223> Streptococcus salivarius K12

<400> 569
Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Val Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Ser Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Asp Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Leu Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Tyr Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Thr Ser Leu Gln Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly His Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Asn Gly Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Met Arg Tyr Lys Glu His Glu Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Ala Tyr Ile Arg Asn Ile Ser Leu Glu Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asn Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Ser 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Arg Leu Leu Ala Gly Leu Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile Tyr Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Asn Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Gly Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Gly Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Asp Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Thr Ile Ile Glu Glu Ile Ile His Thr Leu Thr Met 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Asp Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Val Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Lys Lys Ala Gln Ile Ile Gly Asp Lys Asp Asn Ile Lys 
705                 710                 715                 720 


Gln Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


Glu Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn Gln Tyr Thr 
        755                 760                 765             


Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg Leu Glu Glu 
    770                 775                 780                 


Ser Leu Lys Gly Leu Gly Ser Lys Ile Leu Lys Glu Asn Val Pro Thr 
785                 790                 795                 800 


Arg Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp Arg Leu Tyr 
                805                 810                 815     


Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Glu Leu 
            820                 825                 830         


Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile Ile Pro Gln 
        835                 840                 845             


Ala Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Val Ser Ser 
    850                 855                 860                 


Ala Ser Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Val Val 
865                 870                 875                 880 


Lys Lys Arg Lys Thr Leu Trp Tyr Gln Leu Leu Lys Ser Lys Leu Ile 
                885                 890                 895     


Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu 
            900                 905                 910         


Ser Gln Glu Glu Lys Ala Gly Phe Ile Gln Arg Gln Leu Val Glu Thr 
        915                 920                 925             


Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu Arg Phe Asn 
    930                 935                 940                 


Asn Lys Lys Asp Glu Asn Asn Arg Thr Leu Arg Thr Val Lys Ile Ile 
945                 950                 955                 960 


Thr Leu Lys Ser Ser Leu Val Ser Gln Phe Arg Lys Asp Phe Glu Leu 
                965                 970                 975     


Tyr Lys Val Arg Glu Ile Asn Asp Phe His His Ala His Asp Ala Tyr 
            980                 985                 990         


Leu Asn Ala Val Val Ala Ser Ala  Leu Leu Lys Lys Tyr  Pro Lys Leu 
        995                 1000                 1005             


Glu Pro  Glu Phe Val Tyr Gly  Asp Tyr Pro Lys Tyr  Asn Ser Phe 
    1010                 1015                 1020             


Arg Glu  Arg Lys Ser Ala Thr  Glu Lys Val Tyr Phe  Tyr Ser Asn 
    1025                 1030                 1035             


Ile Met  Asn Ile Phe Lys Lys  Ser Ile Pro Leu Ala  Asp Gly Thr 
    1040                 1045                 1050             


Val Ile  Asp Arg Pro Leu Ile  Glu Val Asn Glu Glu  Thr Gly Glu 
    1055                 1060                 1065             


Ser Val  Trp Asn Lys Val Ala  Asp Leu Asn Thr Val  Arg Lys Val 
    1070                 1075                 1080             


Leu Ser  Tyr Ser Gln Val Asn  Ile Val Lys Lys Val  Glu Glu Gln 
    1085                 1090                 1095             


Asn His  Gly Leu Asp Arg Gly  Lys Pro Lys Gly Leu  Phe Asn Ala 
    1100                 1105                 1110             


Asn Leu  Ser Ser Lys Pro Lys  Pro Asn Ser Lys Glu  Asn Leu Val 
    1115                 1120                 1125             


Gly Ala  Lys Glu Tyr Leu Asp  Pro Lys Lys Tyr Gly  Gly Tyr Ala 
    1130                 1135                 1140             


Gly Ile  Ser Asn Ser Phe Ala  Ile Leu Val Lys Gly  Thr Ile Glu 
    1145                 1150                 1155             


Lys Gly  Ala Lys Lys Lys Ile  Thr Asn Val Leu Glu  Phe Gln Gly 
    1160                 1165                 1170             


Ile Ser  Ile Leu Asp Arg Ile  Tyr Tyr Arg Lys Asp  Lys Leu Asn 
    1175                 1180                 1185             


Phe Leu  Leu Glu Lys Gly Tyr  Lys Asp Ile Glu Leu  Ile Ile Glu 
    1190                 1195                 1200             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Ser Asp Gly  Ser Arg Arg 
    1205                 1210                 1215             


Met Leu  Ala Ser Ile Leu Ser  Thr Asn Asn Lys Arg  Gly Glu Ile 
    1220                 1225                 1230             


His Lys  Gly Asn Gln Ile Phe  Ile Ser Gln Lys Phe  Val Lys Leu 
    1235                 1240                 1245             


Leu Tyr  His Ala Lys Arg Ile  Ser Ser Thr Phe Asn  Glu Asn His 
    1250                 1255                 1260             


Arg Lys  Tyr Val Glu Asn His  Lys Lys Glu Phe Glu  Glu Leu Phe 
    1265                 1270                 1275             


Tyr Tyr  Ile Leu Glu Phe Asn  Glu Asn Tyr Val Gly  Ala Lys Lys 
    1280                 1285                 1290             


Asn Gly  Glu Leu Leu Lys Ser  Ala Phe Gln Ser Trp  Gln Asn His 
    1295                 1300                 1305             


Ser Ile  Asp Glu Leu Cys Ser  Ser Phe Ile Gly Pro  Thr Gly Ser 
    1310                 1315                 1320             


Glu Arg  Lys Gly Leu Phe Glu  Leu Thr Ser Arg Gly  Gly Ala Ala 
    1325                 1330                 1335             


Asp Phe  Glu Phe Leu Gly Val  Lys Ile Pro Arg Tyr  Arg Asp Tyr 
    1340                 1345                 1350             


Thr Pro  Ser Ser Leu Leu Lys  Asp Ala Thr Leu Ile  His Gln Ser 
    1355                 1360                 1365             


Val Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1370                 1375                 1380             


Glu Asp  
    1385 


<210> 570
<211> 1135
<212> PRT
<213> Streptococcus salivarius


<220>
<223> Streptococcus salivarius PS4

<400> 570
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Glu Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn His Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Val Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Ala Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Lys Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Glu Asp Gly Arg 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr His Ala Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Ser Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Lys 
225                 230                 235                 240 


Tyr Thr Thr Lys Lys Asp Ala Gln Gly Gln Tyr Ile Thr Leu Asn Asn 
                245                 250                 255     


Ile Phe Gly Ile Leu Ile Gly Lys Cys Thr Phe Tyr Pro Glu Glu Tyr 
            260                 265                 270         


Arg Ala Ala Lys Ala Ser Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn 
        275                 280                 285             


Asp Leu Asn Asn Leu Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu 
    290                 295                 300                 


Glu Gln Lys Tyr Gln Ile Ile Thr Tyr Val Lys Asn Glu Lys Ala Met 
305                 310                 315                 320 


Gly Pro Ala Lys Leu Phe Lys Tyr Ile Ala Lys Leu Leu Ala Cys Asp 
                325                 330                 335     


Ile Ala Asp Ile Lys Gly Tyr Arg Ile Asp Lys Ser Asp Lys Ala Glu 
            340                 345                 350         


Ile His Thr Phe Glu Ala Tyr Arg Lys Met Lys Thr Leu Glu Thr Ile 
        355                 360                 365             


Asp Ile Glu Gln Ile Glu Arg Glu Lys Leu Asp Lys Leu Ala Tyr Val 
    370                 375                 380                 


Leu Thr Leu Asn Thr Glu Arg Glu Gly Ile Gln Glu Ala Leu Asp His 
385                 390                 395                 400 


Glu Phe Ala Asp Gly Thr Phe Ser Gln Glu Gln Val Asp Glu Leu Val 
                405                 410                 415     


Gln Phe Arg Lys Ala Asn Ser Ser Ile Phe Gly Lys Gly Trp His Ser 
            420                 425                 430         


Phe Ser Val Lys Leu Met Met Glu Leu Ile Pro Glu Leu Tyr Ala Thr 
        435                 440                 445             


Ser Glu Glu Gln Met Thr Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr 
    450                 455                 460                 


Thr Ser Ser Ser Asn Lys Thr Lys Tyr Ile Asp Glu Lys Gln Leu Thr 
465                 470                 475                 480 


Glu Glu Ile Tyr Asn Pro Val Val Ala Lys Ser Val Arg Gln Ala Ile 
                485                 490                 495     


Lys Ile Val Asn Ala Ala Ile Lys Lys Tyr Gly Asp Phe Asp Asn Ile 
            500                 505                 510         


Val Ile Glu Met Ala Arg Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala 
        515                 520                 525             


Ile Gln Lys Ile Gln Lys Ala Asn Lys Ala Glu Lys Asp Ala Ala Met 
    530                 535                 540                 


Arg Lys Ala Ala Asn Gln Tyr Asn Gly Lys Ala Glu Leu Pro His Ser 
545                 550                 555                 560 


Val Phe His Gly His Lys Gln Leu Ala Thr Lys Ile Arg Leu Trp His 
                565                 570                 575     


Gln Gln Gly Glu Arg Cys Leu Tyr Thr Gly Lys Thr Ile Ser Ile His 
            580                 585                 590         


Asp Leu Ile Asn Asn Pro Asn Gln Phe Glu Ile Asp His Ile Leu Pro 
        595                 600                 605             


Leu Ser Ile Thr Phe Asp Asp Ser Leu Ala Asn Lys Val Leu Val Tyr 
    610                 615                 620                 


Ala Thr Ala Asn Gln Glu Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu 
625                 630                 635                 640 


Asp Ser Met Asp Asp Ala Trp Ser Phe Arg Glu Leu Lys Ala Phe Val 
                645                 650                 655     


Arg Glu Ser Lys Ala Leu Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr 
            660                 665                 670         


Glu Glu Asp Ile Ser Lys Phe Asp Val Arg Lys Lys Phe Ile Glu Arg 
        675                 680                 685             


Asn Leu Val Asp Thr Arg Tyr Ala Ser Arg Val Val Leu Asn Ala Leu 
    690                 695                 700                 


Gln Glu His Phe Lys Ala His Lys Ile Asp Thr Lys Val Ser Val Val 
705                 710                 715                 720 


Arg Gly Gln Phe Thr Ser Gln Leu Arg Arg His Trp Gly Ile Asp Lys 
                725                 730                 735     


Thr Arg Asp Thr Tyr His His His Ala Val Asp Ala Leu Ile Ile Ala 
            740                 745                 750         


Ala Ser Ser Gln Leu Asn Leu Trp Lys Lys Gln Lys Asn Thr Leu Val 
        755                 760                 765             


Ser Tyr Ser Glu Asp Gln Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile 
    770                 775                 780                 


Ser Asp Asp Glu Tyr Lys Glu Ser Val Phe Lys Ala Pro Tyr Gln His 
785                 790                 795                 800 


Phe Val Asp Thr Leu Lys Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe 
                805                 810                 815     


Ser Tyr Gln Val Asp Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr 
            820                 825                 830         


Ile Tyr Ala Thr Arg Gln Ala Lys Val Gly Lys Asp Lys Lys Asp Glu 
        835                 840                 845             


Thr Tyr Val Leu Gly Lys Ile Lys Asp Ile Tyr Ala Leu Gly Thr Lys 
    850                 855                 860                 


Thr Pro Ser Lys Thr Gly Phe Tyr Lys Phe Leu Asp Leu Tyr Asn Lys 
865                 870                 875                 880 


Asp Lys Ser Gln Phe Leu Val Tyr Gln Lys Asp Arg Lys Thr Trp Asp 
                885                 890                 895     


Glu Val Ile Glu Lys Ile Met Glu Gln Tyr Arg Pro Phe Lys Glu Ser 
            900                 905                 910         


Asp Lys Asn Gly Lys Glu Val Asp Phe Asn Pro Phe Glu Lys Tyr Arg 
        915                 920                 925             


Ile Glu Asn Gly Pro Ile Arg Lys Tyr Ser Arg Lys Gly Asn Gly Pro 
    930                 935                 940                 


Glu Ile Lys Ser Leu Lys Tyr Tyr Ala Ser Lys Leu Gly Asn His Ile 
945                 950                 955                 960 


Asp Ile Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln Ser Val 
                965                 970                 975     


Ser Pro Trp Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr Gly Ser Tyr 
            980                 985                 990         


Glu Ile Leu Gly Leu Lys Tyr Ala  Asp Leu Gln Phe Glu  Lys Gly Thr 
        995                 1000                 1005             


Gly Thr  Tyr Arg Ile Ser Glu  Glu Lys Tyr Asn Asp  Ile Lys Lys 
    1010                 1015                 1020             


Lys Glu  Gly Val Asp Ser Asp  Ser Glu Phe Lys Phe  Thr Leu Tyr 
    1025                 1030                 1035             


Lys Asn  Asp Leu Leu Leu Ile  Lys Asp Thr Glu Thr  Lys Glu Gln 
    1040                 1045                 1050             


Arg Leu  Phe Arg Phe Leu Ser  Arg Ser Met Pro Asn  Lys Lys His 
    1055                 1060                 1065             


Tyr Val  Glu Leu Lys Pro Tyr  Ser Lys Asp Lys Phe  Glu Lys Asn 
    1070                 1075                 1080             


Glu Ser  Leu Ile Glu Ile Leu  Gly Ser Ala Asp Lys  Ser Gly Arg 
    1085                 1090                 1095             


Cys Ile  Lys Gly Leu Ala Lys  Ser Asn Leu Ser Ile  Phe Lys Val 
    1100                 1105                 1110             


Arg Thr  Asp Val Leu Gly Asn  Gln His Ile Ile Lys  Asn Glu Gly 
    1115                 1120                 1125             


Asp Lys  Pro Lys Leu Asp Phe  
    1130                 1135 


<210> 571
<211> 1377
<212> PRT
<213> Streptococcus sanguinis


<220>
<223> Streptococcus sanguinis SK115

<400> 571
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ser Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Ile Ser Lys Leu Asp Ser Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Glu Glu Glu Lys Glu Tyr 
        115                 120                 125             


His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp Ile 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln Val 
        195                 200                 205             


Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Thr Lys Arg Glu Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Ser Asp Glu Lys Ser Thr Gly Leu Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Gly Phe Ala Asp 
        275                 280                 285             


Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Glu Arg Tyr Glu Asn His Gln Glu Asp Leu Ala Ala Leu Lys 
                325                 330                 335     


Gln Phe Ile Lys Asn Asn Leu Ser Glu Lys Tyr Ala Glu Val Phe Ser 
            340                 345                 350         


Asp Gln Ser Lys Asp Gly Tyr Ala Gly Phe Ile Asp Gly Lys Thr Thr 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Leu Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Asn Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Leu Phe 
            420                 425                 430         


Leu Lys Glu Asn Arg Glu Lys Ile Glu Lys Ile Leu Ala Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala Trp 
    450                 455                 460                 


Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly Gln 
    530                 535                 540                 


Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp Asn 
        595                 600                 605             


Pro Lys Asn Gly Glu Ile Leu Glu Asn Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp Thr 
625                 630                 635                 640 


Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Thr Gly Lys Thr Ile Leu Glu Tyr Leu Ile Asp Asp Gly Asp Cys 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe Lys 
    690                 695                 700                 


Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asp Asp Val Lys 
705                 710                 715                 720 


Gln Val Val Gln Glu Ile Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His 
            740                 745                 750         


Asn Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu Asp 
    770                 775                 780                 


Ala Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Asn Ile Leu Lys Glu 
785                 790                 795                 800 


Asn Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr 
                805                 810                 815     


Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Lys Ala Ile Asp Ile 
            820                 825                 830         


Asn Gln Leu Ser Asn Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe 
        835                 840                 845             


Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys Asp 
    850                 855                 860                 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Glu Val Val Gln Lys 
865                 870                 875                 880 


Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser Glu 
                885                 890                 895     


Arg Lys Phe Asn Asn Leu Thr Lys Ala Lys Arg Gly Gly Leu Asp Glu 
            900                 905                 910         


Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Gln Leu Leu Asp Thr Arg Phe Asn Thr Glu 
    930                 935                 940                 


Val Asn Glu Glu Asn Gln Lys Ile Arg Thr Val Lys Ile Ile Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Ala Lys Ala Ile Leu  Lys Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Asp Tyr  Gln Lys Tyr Asp Leu  Lys Arg Tyr 
    1010                 1015                 1020             


Ile Leu  Lys Ser Lys Ala Ser  Asn Thr Ile Asp Lys  Ala Thr Glu 
    1025                 1030                 1035             


Lys Tyr  Phe Phe Tyr Ser Asn  Leu Leu Asn Phe Phe  Lys Glu Lys 
    1040                 1045                 1050             


Val Arg  Tyr Ala Asp Gly Thr  Ile Lys Lys Arg Glu  Asn Ile Glu 
    1055                 1060                 1065             


Tyr Ser  Asn Asp Thr Gly Glu  Ile Ala Trp Asn Lys  Glu Lys Asp 
    1070                 1075                 1080             


Phe Ala  Thr Ile Lys Lys Val  Leu Ser Leu Pro Gln  Val Asn Ile 
    1085                 1090                 1095             


Val Lys  Lys Thr Glu Glu Gln  Thr Val Gly Gln Asn  Gly Gly Leu 
    1100                 1105                 1110             


Phe Asp  Asn Asn Ile Val Ser  Lys Lys Lys Val Val  Asp Ala Ser 
    1115                 1120                 1125             


Lys Leu  Ile Pro Ile Lys Ser  Ser Leu Ser Pro Glu  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Arg Pro Thr Ile  Ala Tyr Ser Val Leu  Val Ile Ala 
    1145                 1150                 1155             


Asp Ile  Glu Lys Gly Lys Gly  Lys Ala Lys Lys Leu  Lys Arg Ile 
    1160                 1165                 1170             


Lys Glu  Ile Val Gly Ile Thr  Ile Gln Asp Lys Lys  Lys Phe Glu 
    1175                 1180                 1185             


Ser Asn  Pro Val Thr Tyr Leu  Glu Glu Cys Gly Tyr  Lys Asn Ile 
    1190                 1195                 1200             


Asn Ser  Asn Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1205                 1210                 1215             


Phe Asn  Asp Gly Gln Arg Arg  Leu Leu Ala Ser Ser  Ile Glu Leu 
    1220                 1225                 1230             


Gln Lys  Gly Asn Glu Leu Ile  Leu Pro Tyr His Leu  Thr Ala Leu 
    1235                 1240                 1245             


Leu Tyr  His Ala Gln Arg Ile  Asn Lys Ile Ser Glu  Pro Ile His 
    1250                 1255                 1260             


Lys Gln  Tyr Val Glu Ala His  Gln Asn Glu Phe Lys  Glu Leu Leu 
    1265                 1270                 1275             


Thr Thr  Ile Ile Ser Leu Ser  Lys Lys Tyr Ile Gln  Lys Pro Asn 
    1280                 1285                 1290             


Val Glu  Leu Leu Leu Gln Gln  Ala Phe Asp Gln Ala  Asp Lys Asp 
    1295                 1300                 1305             


Ile Tyr  Gln Leu Ser Glu Ser  Phe Ile Ser Leu Leu  Lys Leu Thr 
    1310                 1315                 1320             


Ser Phe  Gly Ala Pro Gly Ala  Phe Lys Phe Leu Gly  Val Glu Ile 
    1325                 1330                 1335             


Ser Gln  Ser Ser Val Arg Tyr  Lys Pro Asn Ser Gln  Phe Leu Asp 
    1340                 1345                 1350             


Thr Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Ser Lys Leu Gly  Glu Asp 
    1370                 1375         


<210> 572
<211> 1392
<212> PRT
<213> Streptococcus sanguinis


<220>
<223> Streptococcus sanguinis SK330

<400> 572
Met Glu Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Phe Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Ala Thr Ala Glu Asp Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ser Glu Glu Ile Ser Lys Leu Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Lys Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Glu Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Ser Asp Glu Lys Ser Thr Ser Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Gly Phe Thr 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Ser His Gln Lys Asp Leu Ala Ala Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Asn Asn Leu Pro Lys Arg Tyr Asn Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Glu Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asp Pro Lys Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp 
625                 630                 635                 640 


Ser Ile Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Cys Asp 
            660                 665                 670         


Lys Gln Thr Gly Asp Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Lys 
        675                 680                 685             


Ile Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asp Asp Val 
705                 710                 715                 720 


Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Tyr Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ser Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Asn Ile Leu Lys 
785                 790                 795                 800 


Glu Asn Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Lys Pro Leu Asp 
            820                 825                 830         


Ile Asp Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Gln 
865                 870                 875                 880 


Lys Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp 
            900                 905                 910         


Glu Arg Asp Lys Val Gly Phe Ile Arg Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Ser Phe Asn Thr 
    930                 935                 940                 


Glu Val Asn Glu Lys Asn Gln Lys Ile Arg Thr Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Leu Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Arg Phe Lys Pro  Ser Lys Glu Ile Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Ile Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Ala Thr Ile Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Thr Glu Ile  Gln Thr His Gly Leu  Asp Arg Gly 
    1100                 1105                 1110             


Lys Pro  Lys Gly Leu Phe Asn  Ser Asn Pro Ser Pro  Lys Pro Ser 
    1115                 1120                 1125             


Glu Asp  Ser Lys Glu Asn Leu  Val Pro Ile Lys Gln  Gly Leu Asp 
    1130                 1135                 1140             


Pro Arg  Lys Tyr Gly Gly Tyr  Ala Gly Ile Ser Asn  Ser Tyr Ala 
    1145                 1150                 1155             


Val Leu  Val Lys Ala Ile Val  Glu Lys Gly Ala Lys  Lys Gln Gln 
    1160                 1165                 1170             


Lys Thr  Ile Leu Glu Phe Gln  Gly Ile Ser Ile Leu  Asp Lys Ile 
    1175                 1180                 1185             


Asn Phe  Glu Asn Asn Lys Glu  Asn Tyr Leu Leu Lys  Lys Arg Tyr 
    1190                 1195                 1200             


Ile Glu  Ile Leu Ser Thr Ile  Thr Leu Pro Lys Tyr  Ser Leu Phe 
    1205                 1210                 1215             


Glu Phe  Pro Asp Gly Thr Arg  Arg Arg Leu Ala Ser  Ile Leu Ser 
    1220                 1225                 1230             


Thr Asn  Asn Lys Arg Gly Glu  Ile His Lys Gly Asn  Glu Leu Val 
    1235                 1240                 1245             


Leu Pro  Gly Lys Tyr Thr Thr  Leu Leu Tyr His Ala  Lys Asn Ile 
    1250                 1255                 1260             


Asn Lys  Lys Leu Glu Pro Glu  His Leu Glu Tyr Val  Glu Lys His 
    1265                 1270                 1275             


Arg Asn  Asp Phe Ala Lys Leu  Leu Glu Cys Val Leu  Asn Phe Asn 
    1280                 1285                 1290             


Asp Lys  Tyr Val Gly Ala Leu  Lys Asn Gly Glu Arg  Ile Arg Gln 
    1295                 1300                 1305             


Ala Phe  Thr Asp Trp Glu Thr  Val Asp Ile Glu Lys  Leu Cys Phe 
    1310                 1315                 1320             


Ser Phe  Ile Gly Pro Glu Asn  Ser Lys Asn Ala Gly  Leu Phe Glu 
    1325                 1330                 1335             


Leu Thr  Ser Gln Gly Ser Ala  Ser Asp Phe Glu Phe  Leu Gly Val 
    1340                 1345                 1350             


Lys Ile  Pro Arg Tyr Arg Asp  Tyr Ala Pro Ser Ser  Leu Leu Lys 
    1355                 1360                 1365             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1370                 1375                 1380             


Ile Asp  Leu Ser Lys Leu Gly  Glu Asp 
    1385                 1390         


<210> 573
<211> 1370
<212> PRT
<213> Streptococcus sanguinis


<220>
<223> Streptococcus sanguinis SK353

<400> 573
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Phe Gly Asp Thr Asp Arg Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Thr Leu Leu Phe Asp Asp Gly Asn Thr Ala Glu Ser Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Thr Glu Ser Met Asn Glu Ile Asp Glu Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Glu Tyr 
        115                 120                 125             


His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala Asp 
    130                 135                 140                 


Ser Lys Glu Lys Ser Asp Val Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Thr Phe Asp Ile 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Asn Ile Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln Val 
        195                 200                 205             


Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Glu Glu Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala Asp 
        275                 280                 285             


Leu Phe Leu Ile Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Ala Leu Lys 
                325                 330                 335     


Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Val Glu Val Phe Ser 
            340                 345                 350         


Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Thr 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Asp Asn Arg Asp Phe Ser Trp 
    450                 455                 460                 


Leu Thr Arg Asn Ser Asp Glu Pro Ile Arg Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Ala Arg Ser Ala Glu Asp Phe Ile His Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly Gln 
    530                 535                 540                 


Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Glu Lys Arg Lys Val Thr 
545                 550                 555                 560 


Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Asn Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Thr Lys Asp Lys Glu Phe Met Asp Asp 
        595                 600                 605             


Pro Lys Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp Thr 
625                 630                 635                 640 


Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Asp Lys Ile 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe Lys 
    690                 695                 700                 


Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asp Asp Val Lys 
705                 710                 715                 720 


Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Ala Leu Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu Asp 
    770                 775                 780                 


Ala Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Asn Ile Leu Lys Glu 
785                 790                 795                 800 


Asn Pro Thr Asp Asn Ile Gln Leu Lys Asn Asp Arg Leu Phe Leu Tyr 
                805                 810                 815     


Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Lys Pro Leu Asp Ile 
            820                 825                 830         


Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe 
        835                 840                 845             


Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Asp 
    850                 855                 860                 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Gln Lys 
865                 870                 875                 880 


Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser Glu 
                885                 890                 895     


Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp Glu 
            900                 905                 910         


Arg Asp Lys Val Gly Phe Ile Arg Arg Gln Leu Val Glu Thr Gln Gln 
        915                 920                 925             


Ile Thr Lys Asn Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Thr Glu 
    930                 935                 940                 


Val Lys Glu Lys Asn Gln Lys Ile Arg Thr Val Lys Ile Ile Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Ala Lys Ala Ile Leu  Lys Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Asp Tyr  Gln Lys Tyr Asp Leu  Lys Lys Tyr 
    1010                 1015                 1020             


Ile Ser  Arg Phe Lys Pro Ser  Lys Glu Ile Glu Lys  Ala Thr Glu 
    1025                 1030                 1035             


Lys Tyr  Phe Phe Tyr Ser Asn  Leu Leu Asn Phe Phe  Lys Glu Glu 
    1040                 1045                 1050             


Val Leu  Tyr Ala Asp Gly Thr  Ile Arg Lys Arg Glu  Asn Ile Glu 
    1055                 1060                 1065             


Tyr Ser  Lys Asp Thr Gly Glu  Ile Ala Trp Asp Lys  Glu Lys Asp 
    1070                 1075                 1080             


Phe Ala  Thr Ile Lys Lys Val  Leu Ser Tyr Pro Gln  Val Asn Ile 
    1085                 1090                 1095             


Val Lys  Lys Arg Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1100                 1105                 1110             


Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu Ile Pro  Arg Lys Thr 
    1115                 1120                 1125             


Lys Asp  Ile Leu Trp Asp Thr  Thr Lys Tyr Gly Gly  Phe Asp Ser 
    1130                 1135                 1140             


Pro Val  Ile Ala Tyr Ser Ile  Leu Leu Ile Ala Asp  Ile Glu Lys 
    1145                 1150                 1155             


Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys Thr Leu  Val Gly Ile 
    1160                 1165                 1170             


Thr Ile  Met Glu Lys Ala Ala  Phe Glu Glu Asn Pro  Ile Thr Phe 
    1175                 1180                 1185             


Leu Glu  Asn Lys Gly Tyr His  Asn Val Arg Lys Glu  Asn Ile Leu 
    1190                 1195                 1200             


Cys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Arg 
    1205                 1210                 1215             


Arg Leu  Leu Ala Ser Ala Lys  Glu Leu Gln Lys Gly  Asn Glu Ile 
    1220                 1225                 1230             


Val Leu  Pro Val Cys Leu Thr  Thr Leu Leu Tyr His  Ser Lys Asn 
    1235                 1240                 1245             


Leu His  Lys Leu Asp Glu Pro  Glu His Leu Glu Tyr  Ile Gln Lys 
    1250                 1255                 1260             


His Arg  Asn Glu Phe Lys Asp  Leu Leu Asn Leu Val  Ser Glu Phe 
    1265                 1270                 1275             


Ser Gln  Lys Tyr Ile Leu Ala  Glu Ala Asn Leu Glu  Lys Ile Lys 
    1280                 1285                 1290             


Asp Leu  Tyr Ala Asp Asn Glu  Gln Ala Asp Ile Glu  Ile Leu Ala 
    1295                 1300                 1305             


Asn Ser  Phe Ile Asn Leu Leu  Thr Phe Thr Ala Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Gly  Lys Asp Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Thr  Val Ser Glu Ile Leu  Asn Ala Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1355                 1360                 1365             


Glu Glu  
    1370 


<210> 574
<211> 1421
<212> PRT
<213> Streptococcus sanguinis


<220>
<223> Streptococcus sanguinis SK49

<400> 574
Met Thr Lys Phe Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Val 
1               5                   10                  15      


Ser Ser Val Gly Tyr Ala Val Val Thr Glu Asp Tyr Arg Val Pro Ala 
            20                  25                  30          


Phe Lys Phe Lys Val Leu Gly Asn Thr Glu Lys Glu Lys Ile Lys Lys 
        35                  40                  45              


Asn Leu Ile Gly Ser Thr Thr Phe Val Ser Ala Gln Pro Ala Lys Gly 
    50                  55                  60                  


Thr Arg Val Phe Arg Val Asn Arg Arg Arg Ile Asp Arg Arg Asn His 
65                  70                  75                  80  


Arg Ile Thr Tyr Leu Arg Asp Ile Phe Gln Lys Glu Ile Glu Lys Val 
                85                  90                  95      


Asp Lys Asn Phe Tyr Arg Arg Leu Asp Glu Ser Phe Arg Val Leu Gly 
            100                 105                 110         


Asp Lys Ser Glu Asp Leu Gln Ile Lys Gln Pro Phe Phe Gly Asp Lys 
        115                 120                 125             


Glu Leu Glu Thr Ala Tyr His Lys Lys Tyr Pro Thr Ile Tyr His Leu 
    130                 135                 140                 


Arg Lys His Leu Ala Asp Ala Asp Lys Asn Ser Pro Val Ala Asp Ile 
145                 150                 155                 160 


Arg Glu Val Tyr Met Ala Ile Ser His Ile Leu Lys Tyr Arg Gly His 
                165                 170                 175     


Phe Leu Thr Leu Asp Lys Ile Asn Pro Asn Asn Ile Asn Met Gln Asn 
            180                 185                 190         


Ser Trp Ile Asp Phe Ile Glu Ser Cys Gln Glu Val Phe Asp Leu Glu 
        195                 200                 205             


Ile Ser Asp Glu Ser Lys Asn Ile Ala Asp Ile Phe Lys Ser Ser Glu 
    210                 215                 220                 


Asn Arg Gln Glu Lys Val Lys Lys Ile Leu Pro Tyr Phe Gln Gln Glu 
225                 230                 235                 240 


Leu Leu Lys Lys Asp Lys Ser Ile Phe Lys Gln Leu Leu Gln Leu Leu 
                245                 250                 255     


Phe Gly Leu Lys Thr Lys Phe Lys Asp Cys Phe Glu Leu Glu Glu Glu 
            260                 265                 270         


Pro Asp Leu Asn Phe Ser Lys Glu Asn Tyr Asp Glu Asn Leu Glu Asn 
        275                 280                 285             


Phe Leu Gly Ser Leu Glu Glu Asp Phe Ser Asp Val Phe Ala Lys Leu 
    290                 295                 300                 


Lys Val Leu Arg Asp Thr Ile Leu Leu Ser Gly Met Leu Thr Tyr Thr 
305                 310                 315                 320 


Gly Ala Thr His Ala Arg Phe Ser Ala Thr Met Val Glu Arg Tyr Glu 
                325                 330                 335     


Glu His Arg Lys Asp Leu Gln Arg Phe Lys Phe Phe Ile Lys Gln Asn 
            340                 345                 350         


Leu Ser Glu Gln Asp Tyr Leu Asp Ile Phe Gly Arg Lys Thr Gln Asn 
        355                 360                 365             


Gly Phe Asp Val Asp Lys Glu Thr Lys Gly Tyr Val Gly Tyr Ile Thr 
    370                 375                 380                 


Asn Lys Met Val Leu Thr Asn Pro Gln Lys Gln Lys Thr Ile Gln Gln 
385                 390                 395                 400 


Asn Phe Tyr Asp Tyr Ile Ser Gly Lys Ile Thr Gly Ile Glu Gly Ala 
                405                 410                 415     


Glu Tyr Phe Leu Asn Lys Ile Ser Asp Gly Thr Phe Leu Arg Lys Leu 
            420                 425                 430         


Arg Thr Ser Asp Asn Gly Ala Ile Pro Asn Gln Ile His Ala Tyr Glu 
        435                 440                 445             


Leu Glu Lys Ile Ile Glu Arg Gln Gly Lys Asp Tyr Pro Phe Leu Leu 
    450                 455                 460                 


Glu Asn Lys Asp Lys Leu Leu Ser Ile Leu Thr Phe Lys Ile Pro Tyr 
465                 470                 475                 480 


Tyr Val Gly Pro Leu Ala Lys Gly Ser Asn Ser Arg Phe Ala Trp Ile 
                485                 490                 495     


Lys Arg Ala Thr Ser Ser Asp Ile Leu Asp Asp Asn Asp Glu Asp Thr 
            500                 505                 510         


Arg Asn Gly Lys Ile Arg Pro Trp Asn Tyr Gln Lys Leu Ile Asn Met 
        515                 520                 525             


Asp Glu Thr Arg Asp Ala Phe Ile Thr Asn Leu Ile Gly Asn Asp Ile 
    530                 535                 540                 


Ile Leu Leu Asn Glu Lys Val Leu Pro Lys Arg Ser Leu Ile Tyr Glu 
545                 550                 555                 560 


Glu Val Met Leu Gln Asn Glu Leu Thr Arg Val Lys Tyr Lys Asp Lys 
                565                 570                 575     


Tyr Gly Lys Ala His Phe Phe Asp Ser Glu Leu Arg Gln Asn Ile Ile 
            580                 585                 590         


Asn Gly Leu Phe Lys Asn Asn Ser Lys Arg Val Asn Ala Lys Ser Leu 
        595                 600                 605             


Ile Lys Tyr Leu Ser Asp Asn His Lys Asp Leu Asn Ala Ile Glu Ile 
    610                 615                 620                 


Val Ser Gly Val Glu Lys Gly Lys Ser Phe Asn Ser Thr Leu Lys Thr 
625                 630                 635                 640 


Tyr Asn Asp Leu Lys Thr Ile Phe Ser Glu Glu Leu Leu Asp Ser Glu 
                645                 650                 655     


Ile Tyr Gln Lys Glu Leu Glu Glu Ile Ile Lys Val Ile Thr Val Phe 
            660                 665                 670         


Asp Asp Lys Lys Ser Ile Lys Asn Tyr Leu Thr Lys Phe Phe Gly His 
        675                 680                 685             


Leu Glu Ile Leu Asp Glu Glu Lys Ile Asn Gln Leu Ser Lys Leu Arg 
    690                 695                 700                 


Tyr Ser Gly Trp Gly Arg Tyr Ser Ala Lys Leu Leu Leu Asp Ile Arg 
705                 710                 715                 720 


Asp Glu Asp Thr Gly Phe Asn Leu Leu Gln Phe Leu Arg Asn Asp Glu 
                725                 730                 735     


Glu Asn Arg Asn Leu Thr Lys Leu Ile Ser Asp Asn Thr Leu Ser Phe 
            740                 745                 750         


Glu Pro Lys Ile Lys Asp Ile Gln Ser Lys Ser Thr Ile Glu Asp Asp 
        755                 760                 765             


Ile Phe Asp Glu Ile Lys Lys Leu Ala Gly Ser Pro Ala Ile Lys Arg 
    770                 775                 780                 


Gly Ile Leu Asn Ser Ile Lys Ile Val Asp Glu Leu Val Gln Ile Ile 
785                 790                 795                 800 


Gly Tyr Pro Pro His Asn Ile Val Ile Glu Met Ala Arg Glu Asn Met 
                805                 810                 815     


Thr Thr Glu Glu Gly Gln Lys Lys Ala Lys Thr Arg Lys Thr Lys Leu 
            820                 825                 830         


Glu Ser Ala Leu Lys Asn Ile Glu Asn Ser Leu Leu Glu Asn Gly Lys 
        835                 840                 845             


Val Pro His Ser Asp Glu Gln Leu Gln Ser Glu Lys Leu Tyr Leu Tyr 
    850                 855                 860                 


Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Leu Asp Lys Thr Gly Ser 
865                 870                 875                 880 


Pro Ala Pro Leu Tyr Leu Asp Gln Leu Asp Gln Tyr Glu Val Asp His 
                885                 890                 895     


Ile Ile Pro Tyr Ser Phe Leu Pro Ile Asp Ser Ile Asp Asn Lys Val 
            900                 905                 910         


Leu Thr His Arg Glu Asn Asn Gln Gln Lys Leu Asn Asn Ile Pro Asp 
        915                 920                 925             


Lys Glu Thr Val Ala Asn Met Lys Pro Phe Trp Glu Lys Leu Tyr Asn 
    930                 935                 940                 


Ala Lys Leu Ile Ser Gln Thr Lys Tyr Gln Arg Leu Thr Thr Ser Glu 
945                 950                 955                 960 


Arg Thr Pro Asp Gly Val Leu Thr Glu Ser Met Lys Ala Gly Phe Ile 
                965                 970                 975     


Glu Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Lys His Val Ala Arg 
            980                 985                 990         


Ile Leu Asp Asn Arg Phe Ser Asp  Thr Lys Ile Ile Thr  Leu Lys Ser 
        995                 1000                 1005             


Gln Leu  Ile Thr Asn Phe Arg  Asn Thr Phe His Ile  Ala Lys Ile 
    1010                 1015                 1020             


Arg Glu  Leu Asn Asp Tyr His  His Ala His Asp Ala  Tyr Leu Ala 
    1025                 1030                 1035             


Val Val  Val Gly Gln Thr Leu  Leu Lys Val Tyr Pro  Lys Leu Ala 
    1040                 1045                 1050             


Pro Glu  Leu Ile Tyr Gly His  His Ala His Phe Asn  Arg His Glu 
    1055                 1060                 1065             


Glu Asn  Lys Ala Thr Leu Arg  Lys His Leu Tyr Ser  Asn Ile Met 
    1070                 1075                 1080             


Arg Phe  Phe Asn Asn Pro Asp  Ser Lys Val Ser Lys  Asp Ile Trp 
    1085                 1090                 1095             


Asp Cys  Asn Arg Asp Leu Pro  Ile Ile Lys Asp Val  Ile Tyr Asn 
    1100                 1105                 1110             


Ser Gln  Ile Asn Phe Val Lys  Arg Thr Met Ile Lys  Lys Gly Ala 
    1115                 1120                 1125             


Phe Tyr  Asn Gln Asn Pro Val  Gly Lys Phe Asn Lys  Gln Leu Ala 
    1130                 1135                 1140             


Ala Asn  Asn Arg Tyr Pro Leu  Lys Thr Lys Ala Leu  Cys Leu Asp 
    1145                 1150                 1155             


Thr Ser  Ile Tyr Gly Gly Tyr  Gly Pro Met Asn Ser  Ala Leu Ser 
    1160                 1165                 1170             


Ile Ile  Ile Ile Ala Glu Arg  Phe Asn Glu Lys Lys  Gly Lys Ile 
    1175                 1180                 1185             


Glu Thr  Val Lys Glu Phe His  Asp Ile Phe Ile Ile  Asp Tyr Glu 
    1190                 1195                 1200             


Lys Phe  Asn Asn Asn Pro Phe  Gln Phe Leu Asn Asp  Thr Ser Glu 
    1205                 1210                 1215             


Asn Gly  Phe Leu Lys Lys Asn  Asn Ile Asn Arg Val  Leu Gly Phe 
    1220                 1225                 1230             


Tyr Arg  Ile Pro Lys Tyr Ser  Leu Met Gln Lys Ile  Asp Gly Thr 
    1235                 1240                 1245             


Arg Met  Leu Phe Glu Ser Lys  Ser Asn Leu His Lys  Ala Thr Gln 
    1250                 1255                 1260             


Phe Lys  Leu Thr Lys Thr Gln  Asn Glu Leu Phe Phe  His Met Lys 
    1265                 1270                 1275             


Arg Leu  Leu Thr Lys Ser Asn  Leu Met Asp Leu Lys  Ser Lys Ser 
    1280                 1285                 1290             


Ala Ile  Lys Glu Ser Gln Asn  Phe Ile Leu Lys His  Lys Glu Glu 
    1295                 1300                 1305             


Phe Asp  Asn Ile Ser Asn Gln  Leu Ser Ala Phe Ser  Gln Lys Met 
    1310                 1315                 1320             


Leu Gly  Asn Thr Thr Ser Leu  Lys Asn Leu Ile Lys  Gly Tyr Asn 
    1325                 1330                 1335             


Glu Arg  Lys Ile Lys Glu Ile  Asp Ile Arg Asp Glu  Thr Ile Lys 
    1340                 1345                 1350             


Tyr Phe  Tyr Asp Asn Phe Ile  Lys Met Phe Ser Phe  Val Lys Ser 
    1355                 1360                 1365             


Gly Ala  Pro Lys Asp Ile Asn  Asp Phe Phe Asp Asn  Lys Cys Thr 
    1370                 1375                 1380             


Val Ala  Arg Met Arg Pro Lys  Pro Asp Lys Lys Leu  Leu Asn Ala 
    1385                 1390                 1395             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1400                 1405                 1410             


Asp Leu  Ser Lys Leu Gly Glu  Asp 
    1415                 1420     


<210> 575
<211> 1026
<212> PRT
<213> Streptococcus sp.


<220>
<223> Streptococcus sp. BS35b

<400> 575
Met Asn Gly Leu Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Glu Lys Asn Ser Gly Lys Ile Ile His Ala Asn Ser 
            20                  25                  30          


Arg Leu Phe Pro Ala Ala Thr Ala Asp Asn Asn Val Glu Arg Arg Lys 
        35                  40                  45              


Asn Arg Gln Ala Arg Arg Leu Asn Arg Arg Lys Lys His Arg Gly Val 
    50                  55                  60                  


Arg Phe Gln Asp Leu Phe Glu Asp Tyr Gly Leu Leu Thr Asp Phe Ser 
65                  70                  75                  80  


Lys Val Ser Ile Asn Leu Asn Pro Tyr Arg Leu Arg Val Asp Gly Leu 
                85                  90                  95      


Asn Gln Gln Leu Thr Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Ile 
            100                 105                 110         


Val Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly 
        115                 120                 125             


Gly Ala Val Ser Ser Asp Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 
    130                 135                 140                 


Leu Leu Ala Glu Gln Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe Glu 
145                 150                 155                 160 


Lys Tyr Gly Gln Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly Glu 
                165                 170                 175     


Lys Arg Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Arg Lys Glu 
            180                 185                 190         


Ala Glu Lys Ile Leu Arg Lys Gln Gln Glu Phe Asn Asn Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Glu Asp Tyr Leu Lys Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Val Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asn Glu Tyr Arg Ala Ser Lys Ser Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Lys Val Ile 
    290                 295                 300                 


Val Glu Tyr Ala Lys Glu Ala Lys Thr Leu Gly Ala Ser Thr Leu Leu 
305                 310                 315                 320 


Lys Tyr Ile Val Lys Met Ile Asp Ala Ser Val Asp Gln Ile Ser Gly 
                325                 330                 335     


Tyr Arg Val Asp Val Asn Asn Lys Pro Glu Met His Thr Phe Glu Val 
            340                 345                 350         


Tyr Arg Lys Met Gln Ser Leu Glu Thr Ile Ser Val Gly Glu Leu Ser 
        355                 360                 365             


Arg Asn Val Leu Asp Glu Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Glu Ala Ile Asn Ser Lys Leu Met Gly Val Phe 
385                 390                 395                 400 


Ser Gln Asp Gln Val Leu Glu Leu Val Gln Phe Arg Lys Asn Asn Ser 
                405                 410                 415     


Ser Leu Phe Ser Lys Gly Trp His Asn Phe Ser Leu Lys Leu Met Met 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Gly Lys Gln Lys Ser Lys Glu Thr Ser Lys Arg Thr 
    450                 455                 460                 


Lys Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn Pro Val 
465                 470                 475                 480 


Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Glu Ala Thr 
                485                 490                 495     


Lys Lys His Gly Ile Phe Asp Asn Ile Val Ile Glu Met Ala Arg Glu 
            500                 505                 510         


Asn Asn Glu Glu Asp Ala Lys Lys Asp Tyr Ile Lys Arg Gln Lys Ala 
        515                 520                 525             


Asn Gln Asp Glu Lys Asn Ala Ala Met Glu Lys Ala Ala Phe Gln Tyr 
    530                 535                 540                 


Asn Gly Lys Lys Glu Leu Pro Gly Asn Ile Phe Asn Gly His Lys Glu 
545                 550                 555                 560 


Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys Cys Leu 
                565                 570                 575     


Tyr Thr Gly Lys Thr Ile Pro Ile Ser Asp Leu Ile His Asn Gln Tyr 
            580                 585                 590         


Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp Asp 
        595                 600                 605             


Ser Leu Ser Asn Lys Val Leu Val His Ala Thr Ala Asn Gln Glu Lys 
    610                 615                 620                 


Gly Gln Arg Thr Pro Phe Gln Ala Leu Asp Ser Met Asp Asp Ala Trp 
625                 630                 635                 640 


Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys Asp Leu Lys Ser Leu Ser 
                645                 650                 655     


Asn Lys Lys Lys Asp Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys Ile 
            660                 665                 670         


Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg Tyr 
        675                 680                 685             


Ser Ser Arg Val Val Leu Asn Ala Leu Gln Asp Phe Tyr Lys Ser His 
    690                 695                 700                 


Gln Phe Asp Thr Thr Ile Ser Val Val Arg Gly Gln Phe Thr Ser Gln 
705                 710                 715                 720 


Leu Arg Arg Lys Trp Gly Leu Glu Lys Ser Arg Glu Thr Tyr His His 
                725                 730                 735     


His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg Leu 
            740                 745                 750         


Trp Lys Lys Gln Asn Asn Pro Leu Ile Thr Tyr Lys Glu Gly Gln Phe 
        755                 760                 765             


Ile Asp Ser Gln Thr Gly Glu Ile Ile Ser Leu Thr Asp Asp Glu Tyr 
    770                 775                 780                 


Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp Thr Leu 
785                 790                 795                 800 


His Ser Lys Thr Phe Glu Asp Gly Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Tyr Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Lys Ala Lys Leu Asp Lys Asp Lys Ser Glu Glu Thr Tyr Val Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ser Gln Ala Gly Tyr Asp Ala Phe Ile Lys 
    850                 855                 860                 


Ile Tyr Asn Lys Asp Lys Arg Lys Phe Leu Met Tyr His Lys Asp Pro 
865                 870                 875                 880 


Gln Thr Phe Glu Lys Val Ile Glu Glu Ile Leu Arg Thr Tyr Pro Ser 
                885                 890                 895     


Lys Glu Arg Asn Asp Lys Asn Lys Glu Val Pro Cys Asn Pro Phe Glu 
            900                 905                 910         


Lys Tyr Arg Gln Glu Asn Gly Pro Ile Arg Lys Tyr Ser Lys Lys Gly 
        915                 920                 925             


Asn Gly Pro Glu Ile Lys Cys Leu Lys Tyr Tyr Asp Asn Lys Leu Gly 
    930                 935                 940                 


Asn Tyr Ile Asp Ile Ser Pro Asp Gly Ser Asp Asn Gln Val Val Leu 
945                 950                 955                 960 


Gln Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn His Gln Thr 
                965                 970                 975     


Lys Lys Tyr Glu Leu Met Gly Leu Lys Tyr Ser Asp Leu Ser Phe Glu 
            980                 985                 990         


Lys Gly Ser Gly Lys Tyr Ser Ile  Ser Asn Glu Lys Tyr  Asn Ser Ile 
        995                 1000                 1005             


Lys Arg  Ile Glu Gly Val Asn  Glu Gln Ser Glu Phe  Lys Phe Thr 
    1010                 1015                 1020             


Leu Tyr  Lys 
    1025     


<210> 576
<211> 1139
<212> PRT
<213> Streptococcus sp.


<220>
<223> Streptococcus sp. C150

<400> 576
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Glu Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn His Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Val Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Ala Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Lys Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Glu Asp Gly Arg 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr His Ala Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Ser Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Lys 
225                 230                 235                 240 


Tyr Thr Thr Lys Lys Asp Ala Gln Gly Gln Tyr Ile Thr Leu Asn Asn 
                245                 250                 255     


Ile Phe Gly Ile Leu Ile Gly Lys Cys Thr Phe Tyr Pro Glu Glu Tyr 
            260                 265                 270         


Arg Ala Ala Lys Ala Ser Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn 
        275                 280                 285             


Asp Leu Asn Asn Leu Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu 
    290                 295                 300                 


Glu Gln Lys Tyr Gln Ile Ile Thr Tyr Val Lys Asn Glu Lys Ala Met 
305                 310                 315                 320 


Gly Pro Ala Lys Leu Phe Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp 
                325                 330                 335     


Val Ala Asp Ile Lys Gly Tyr Arg Ile Asp Lys Ser Asp Lys Ala Glu 
            340                 345                 350         


Ile His Thr Phe Glu Ala Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu 
        355                 360                 365             


Asp Val Lys Lys Met Ala Arg Glu Glu Leu Asp Lys Leu Ala Tyr Val 
    370                 375                 380                 


Leu Thr Leu Asn Thr Glu Arg Glu Gly Ile Gln Glu Ala Leu Asp His 
385                 390                 395                 400 


Glu Phe Ala Asp Gly Thr Phe Ser Gln Glu Gln Val Asp Glu Leu Val 
                405                 410                 415     


Gln Phe Arg Lys Ala Asn Ser Ser Ile Phe Gly Lys Gly Trp His Ser 
            420                 425                 430         


Phe Ser Val Lys Leu Met Met Glu Leu Ile Pro Glu Leu Tyr Ala Thr 
        435                 440                 445             


Ser Glu Glu Gln Met Thr Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr 
    450                 455                 460                 


Thr Ser Ser Ser Asn Lys Thr Lys Tyr Ile Asp Glu Lys Gln Leu Thr 
465                 470                 475                 480 


Glu Glu Ile Tyr Asn Pro Val Val Ala Lys Ser Val Arg Gln Ala Ile 
                485                 490                 495     


Lys Ile Val Asn Ala Ala Ile Lys Lys Tyr Gly Asp Phe Asp Asn Ile 
            500                 505                 510         


Val Ile Glu Met Ala Arg Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala 
        515                 520                 525             


Ile Gln Lys Ile Gln Lys Ala Asn Lys Ala Glu Lys Asp Ala Ala Met 
    530                 535                 540                 


Arg Lys Ala Ala Asn Gln Tyr Asn Gly Lys Ala Glu Leu Pro His Ser 
545                 550                 555                 560 


Val Phe His Gly His Lys Gln Leu Ala Thr Lys Ile Arg Leu Trp His 
                565                 570                 575     


Gln Gln Gly Glu Arg Cys Leu Tyr Thr Gly Lys Thr Ile Ser Ile His 
            580                 585                 590         


Asp Leu Ile Asn Asn Pro Asn Gln Phe Glu Ile Asp His Ile Leu Pro 
        595                 600                 605             


Leu Ser Ile Thr Phe Asp Asp Ser Leu Ala Asn Lys Val Leu Val Tyr 
    610                 615                 620                 


Ala Thr Ala Asn Gln Glu Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu 
625                 630                 635                 640 


Asp Ser Met Asp Asp Ala Trp Ser Phe Arg Glu Leu Lys Ala Phe Val 
                645                 650                 655     


Arg Glu Ser Lys Ala Leu Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr 
            660                 665                 670         


Glu Glu Asp Ile Ser Lys Phe Asp Val Arg Lys Lys Phe Ile Glu Arg 
        675                 680                 685             


Asn Leu Val Asp Thr Arg Tyr Ala Ser Arg Val Val Leu Asn Ala Leu 
    690                 695                 700                 


Gln Glu His Phe Arg Thr His Lys Ile Asp Thr Lys Val Ser Val Val 
705                 710                 715                 720 


Arg Gly Gln Phe Thr Ser Gln Leu Arg Arg His Trp Gly Ile Glu Lys 
                725                 730                 735     


Thr Arg Asp Thr Tyr His His His Ala Val Asp Ala Leu Ile Ile Ala 
            740                 745                 750         


Ala Ser Ser Gln Leu Asn Leu Trp Lys Lys Gln Lys Asn Thr Leu Val 
        755                 760                 765             


Ser Tyr Ser Glu Asp Gln Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile 
    770                 775                 780                 


Ser Asp Asp Glu Tyr Lys Glu Ser Val Phe Lys Ala Pro Tyr Gln His 
785                 790                 795                 800 


Phe Val Asp Thr Leu Lys Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe 
                805                 810                 815     


Ser Tyr Gln Val Asp Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr 
            820                 825                 830         


Ile Tyr Ala Thr Arg Lys Ala Lys Leu Asp Lys Glu Lys Lys Glu Tyr 
        835                 840                 845             


Thr Tyr Thr Leu Gly Lys Ile Lys Asp Ile Tyr Ala Leu Gly Thr Lys 
    850                 855                 860                 


Thr Pro Ser Lys Thr Gly Phe Tyr Lys Phe Leu Asp Leu Tyr Lys Lys 
865                 870                 875                 880 


Asp Lys Ser Gln Phe Leu Met Tyr Gln Lys Asp Arg Arg Thr Trp Asp 
                885                 890                 895     


Glu Val Ile Glu Lys Ile Leu Glu Gln Tyr Arg Pro Phe Lys Glu Lys 
            900                 905                 910         


Asp Lys Asn Gly Lys Glu Val Asp Phe Asn Pro Phe Glu Lys Tyr Arg 
        915                 920                 925             


Ile Glu Asn Gly Pro Ile Arg Lys Tyr Ser Arg Lys Gly Asn Gly Pro 
    930                 935                 940                 


Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Leu Leu Gly Arg Phe Val 
945                 950                 955                 960 


Asp Ile Thr Pro Ser Glu Ser Lys Asn Pro Val Ala Leu Leu Ser Leu 
                965                 970                 975     


Asn Pro Trp Arg Thr Asp Val Tyr Tyr Asn Thr Glu Thr Arg Lys Tyr 
            980                 985                 990         


Glu Phe Leu Gly Leu Lys Tyr Ala  Asp Leu Cys Phe Glu  Lys Gly Gly 
        995                 1000                 1005             


Ser Tyr  Gly Ile Ser Lys Val  Lys Tyr Asn Lys Ile  Arg Glu Lys 
    1010                 1015                 1020             


Glu Gly  Ile Gly Lys Asn Ser  Glu Phe Lys Phe Thr  Leu Tyr Lys 
    1025                 1030                 1035             


Asn Asp  Leu Ile Leu Ile Lys  Asp Thr Glu Thr Asn  Arg Gln Gln 
    1040                 1045                 1050             


Ile Phe  Arg Phe Trp Ser Arg  Thr Gly Lys Asp Asn  Pro Lys Ser 
    1055                 1060                 1065             


Phe Glu  Lys His Lys Leu Glu  Leu Lys Pro Tyr Glu  Lys Thr Arg 
    1070                 1075                 1080             


Phe Glu  Lys Gly Glu Glu Leu  Lys Val Leu Gly Lys  Val Pro Pro 
    1085                 1090                 1095             


Ser Ser  Asn Arg Leu Gln Lys  Asn Met Gln Ile Glu  Asn Leu Ser 
    1100                 1105                 1110             


Ile Tyr  Lys Val Arg Thr Asp  Val Leu Gly Asn Gln  His Ile Ile 
    1115                 1120                 1125             


Lys Asn  Glu Gly Asp Lys Pro  Lys Leu Asp Phe 
    1130                 1135                 


<210> 577
<211> 1377
<212> PRT
<213> Streptococcus sp.


<220>
<223> Streptococcus sp. C300

<400> 577
Met Asn Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ser Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Arg Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Ala Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Ile Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Val Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Val Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ala Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Thr Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Glu Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Val Ala Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Val Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Thr Asn Leu Pro Glu Lys Tyr Val Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Asp Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Val Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Thr Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr His Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Met Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Lys Ile Ile Asn Gln Leu Phe Lys Lys Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Asp Asp Ile Ile Asp Cys Leu Gln Lys Ile Asp Asn Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Ile Leu Lys Ile Ile Arg Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asp Pro Lys Asn Gly Asp Ile Leu Glu Asn Val Ile His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asn 
625                 630                 635                 640 


Ser Ile Phe Asp Glu Lys Val Ile Lys Ala Leu Ser Arg Lys His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asp Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Thr Gly Lys Thr Ile Leu Asp Tyr Leu Met Asp Asp Gly Lys 
        675                 680                 685             


Ser Asn Arg Asn Phe Met Gln Leu Ile Lys Asp Asp Glu Leu Ser Phe 
    690                 695                 700                 


Thr Glu Ile Ile Gln Lys Ala Gln Val Val Gly Asp Thr Asp Asn Leu 
705                 710                 715                 720 


Arg Gln Val Val Gln Asn Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ser Leu Lys Asn Leu Ala Ser Gly Leu Asp Ser Asn Ile Leu Lys 
785                 790                 795                 800 


Glu Asn Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asn 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Glu 
865                 870                 875                 880 


Lys Met Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu Arg Lys Tyr Asn Asn Leu Thr Lys Ala Glu Arg Glu Arg Gly Gly 
            900                 905                 910         


Leu Asn Glu Leu Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Phe 
    930                 935                 940                 


Asn Lys Glu Val Thr Glu Lys Asn Lys Lys Asn Arg Asn Val Lys Ile 
945                 950                 955                 960 


Ile Thr Leu Lys Ser Asn Met Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Leu Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Lys Lys  Tyr Pro Lys 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Gln Lys  Tyr Asp Leu 
    1010                 1015                 1020             


Lys Arg  Tyr Ile Ser Arg Ser  Lys Asp Pro Lys Glu  Val Glu Lys 
    1025                 1030                 1035             


Ala Thr  Glu Lys Tyr Phe Phe  Tyr Ser Asn Leu Leu  Asn Phe Phe 
    1040                 1045                 1050             


Lys Glu  Glu Val His Tyr Ala  Asp Gly Thr Ile Val  Lys Arg Glu 
    1055                 1060                 1065             


Asn Ile  Glu Tyr Ser Lys Asp  Thr Gly Glu Ile Ala  Trp Asn Lys 
    1070                 1075                 1080             


Glu Lys  Asp Phe Ala Thr Ile  Lys Lys Val Leu Ser  Leu Pro Gln 
    1085                 1090                 1095             


Val Asn  Ile Val Lys Lys Thr  Glu Glu Gln Thr Val  Gly Gln Asn 
    1100                 1105                 1110             


Gly Gly  Leu Phe Asp Asn Asn  Ile Val Ser Lys Lys  Lys Val Val 
    1115                 1120                 1125             


Asp Ala  Ser Lys Leu Ile Pro  Ile Lys Ser Gly Leu  Ser Pro Glu 
    1130                 1135                 1140             


Lys Tyr  Gly Gly Tyr Ala Arg  Pro Thr Ile Ala Tyr  Ser Val Leu 
    1145                 1150                 1155             


Val Thr  Tyr Lys Gln Asn Asn  Lys Ile Lys Asn Thr  Met Val Gly 
    1160                 1165                 1170             


Ile Pro  Val Leu Thr Lys Leu  Glu Phe Glu Arg Asp  Pro Asn Leu 
    1175                 1180                 1185             


Tyr Leu  Arg Asn Leu Gly Ile  Asn Asn Val Ser His  Val Ile Lys 
    1190                 1195                 1200             


Leu Val  Lys Tyr Thr Val Leu  Glu Phe Lys His Lys  Tyr Gly Thr 
    1205                 1210                 1215             


Tyr Arg  Arg Phe Ile Val Ser  Asn Gln Glu Leu Lys  Arg Ala Asn 
    1220                 1225                 1230             


Gln Ile  Phe Val Thr Thr Lys  Gln Met Lys Leu Ile  Ser Gln Tyr 
    1235                 1240                 1245             


Thr Thr  Leu Asp Lys Asn Glu  His Asp Ser Leu Leu  Lys Asn Asn 
    1250                 1255                 1260             


Gln Gln  Leu Ile Gln Ser Ile  Trp Asn Gln Phe Leu  Glu Phe Met 
    1265                 1270                 1275             


Leu Ala  Thr Asp Leu Val Asn  Lys Lys Gln Tyr Asp  Glu Leu Ile 
    1280                 1285                 1290             


Leu Thr  Asn Asn Gln Thr Ile  Glu Glu Cys Arg Asn  Ile Met Asn 
    1295                 1300                 1305             


Arg Val  Ile Thr Thr Leu Ser  Phe Thr Asn Ile Asn  Ala Gly Gln 
    1310                 1315                 1320             


Lys Lys  Ile Ile Phe Asp Asp  Thr Leu Ser Leu Pro  Ile Lys Arg 
    1325                 1330                 1335             


Trp Gln  Phe Thr Asp Ser Asp  Lys Met Val Lys Lys  Ile Ile Glu 
    1340                 1345                 1350             


Ser Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Ser Lys Leu Gly  Glu Asp 
    1370                 1375         


<210> 578
<211> 1371
<212> PRT
<213> Streptococcus sp.


<220>
<223> Streptococcus sp. F0441

<400> 578
Met Glu Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ser Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Ala Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ser Glu Glu Ile Gly Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Ile Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ala Glu Glu Lys Lys 
        115                 120                 125             


Tyr His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ala Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asn Asn Thr Phe Glu Gly Asn Ser Leu Ser Gly Gln Asn Val Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Arg Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asn Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Ser Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Glu Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Thr Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Gln Ile Val Thr Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Gln Phe Leu His Asn Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Ala Phe Met Asp 
        595                 600                 605             


Asp Ala Lys Asn Glu Ala Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp 
625                 630                 635                 640 


Ser Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Ser Asp 
            660                 665                 670         


Lys Gln Thr Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Glu 
        675                 680                 685             


Ile Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asn Asp Val 
705                 710                 715                 720 


Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ser Leu Lys Ile Leu Ala Ser Gly Leu Asn Ser Lys Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asp 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Cys Asp Ile Asp His Ile Ile Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Asp 
865                 870                 875                 880 


Lys Met Lys Val Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Tyr Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asn 
            900                 905                 910         


Glu Leu Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Lys 
    930                 935                 940                 


Glu Val Thr Glu Lys Asp Lys Lys Asn Arg Thr Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Leu Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Arg Ser Lys Asp  Pro Lys Glu Ile Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Thr Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Ala Thr Ile Lys Lys  Val Leu Ser Leu Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Arg Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Pro Lys Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Asp Ile Leu Trp Asp  Thr Thr Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Val Ile Ala Tyr Ser  Ile Leu Leu Ile Ala  Asp Ile Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ala Lys Lys Leu  Lys Thr Val Lys Thr  Leu Val Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Lys Asp  Ala Phe Glu Lys Asn  Pro Ile Ala 
    1175                 1180                 1185             


Phe Leu  Glu Asn Lys Gly Tyr  His Asn Val Cys Lys  Glu Asn Ile 
    1190                 1195                 1200             


Leu Cys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Leu Gln Lys  Cys Asn Glu 
    1220                 1225                 1230             


Ile Val  Leu Pro Val Tyr Leu  Thr Thr Leu Leu Tyr  His Ser Lys 
    1235                 1240                 1245             


Asn Val  His Lys Leu Asp Glu  Pro Gly His Leu Glu  Tyr Ile Gln 
    1250                 1255                 1260             


Lys His  Arg Asn Glu Phe Lys  Asp Leu Leu Asn Leu  Val Ser Glu 
    1265                 1270                 1275             


Phe Ser  Gln Lys Tyr Val Leu  Ala Asp Ala Asn Leu  Glu Lys Ile 
    1280                 1285                 1290             


Lys Asn  Leu Tyr Ala Asp Asn  Glu Gln Ala Asp Ile  Glu Ile Leu 
    1295                 1300                 1305             


Ala Asn  Ser Phe Ile Asn Leu  Leu Thr Phe Thr Ala  Leu Gly Ala 
    1310                 1315                 1320             


Pro Ala  Ala Phe Lys Phe Phe  Gly Lys Asp Val Asp  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Thr  Thr Val Ser Glu Ile  Leu Asn Ala Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1355                 1360                 1365             


Gly Glu  Asp 
    1370     


<210> 579
<211> 1121
<212> PRT
<213> Streptococcus sp.


<220>
<223> Streptococcus sp. GMD6S

<400> 579
Met Asn Gly Leu Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Glu Lys Asn Ser Gly Lys Ile Ile His Ala Asn Ser 
            20                  25                  30          


Arg Leu Phe Pro Ala Ala Thr Ala Asp Asn Asn Val Glu Arg Arg Lys 
        35                  40                  45              


Asn Arg Gln Ala Arg Arg Leu His Arg Arg Lys Lys His Arg Gly Val 
    50                  55                  60                  


Arg Phe Gln Asp Leu Phe Glu Asp Tyr Gly Leu Leu Thr Asp Phe Ser 
65                  70                  75                  80  


Lys Val Ser Ile Asn Leu Asn Pro Tyr Arg Leu Arg Val Asp Gly Leu 
                85                  90                  95      


Asn Gln Gln Leu Thr Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Ile 
            100                 105                 110         


Val Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly 
        115                 120                 125             


Gly Thr Val Ser Ser Asp Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 
    130                 135                 140                 


Leu Leu Ala Glu Gln Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe Glu 
145                 150                 155                 160 


Lys Tyr Gly Gln Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly Glu 
                165                 170                 175     


Lys Arg Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Arg Lys Glu 
            180                 185                 190         


Ala Glu Arg Ile Leu Arg Lys Gln Gln Glu Phe Asn Ser Lys Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Glu Asp Cys Leu Lys Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Tyr Arg Ala Ser Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Lys Val Ile 
    290                 295                 300                 


Val Glu Tyr Ala Lys Glu Ala Lys Thr Leu Gly Ala Ser Thr Leu Leu 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Met Ile Asp Ala Ser Val Asp Gln Ile Arg Gly 
                325                 330                 335     


Tyr Arg Val Asp Val Asn Asn Lys Pro Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Gln Ser Leu Glu Thr Ile Ser Val Gly Glu Leu Ser 
        355                 360                 365             


Arg Asn Val Leu Asp Glu Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Glu Ala Ile Asn Thr Lys Leu Lys Asp Ser Phe 
385                 390                 395                 400 


Ser Gln Asp Gln Val Leu Glu Leu Val Gln Phe Arg Lys Asn Asn Ser 
                405                 410                 415     


Ser Leu Phe Ser Lys Gly Trp His Asn Phe Ser Leu Lys Leu Met Met 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Gly Lys Gln Lys Ser Lys Glu Ile Ser Lys Arg Thr 
    450                 455                 460                 


Lys Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn Pro Val 
465                 470                 475                 480 


Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Glu Ala Thr 
                485                 490                 495     


Lys Lys His Gly Ile Phe Asp Asn Ile Val Ile Glu Met Ala Arg Glu 
            500                 505                 510         


Asn Asn Glu Glu Asp Ala Lys Lys Asp Tyr Ile Lys Arg Gln Lys Ala 
        515                 520                 525             


Asn Gln Asp Glu Lys Asn Ala Ala Met Glu Lys Ala Ala Phe Gln Tyr 
    530                 535                 540                 


Asn Gly Lys Lys Glu Leu Pro Asp Ser Ile Phe His Gly Gln Lys Glu 
545                 550                 555                 560 


Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys Cys Leu 
                565                 570                 575     


Tyr Thr Gly Lys Asn Ile Pro Ile Ser Asp Leu Ile His Asn Gln Tyr 
            580                 585                 590         


Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp Asp 
        595                 600                 605             


Ser Leu Ser Asn Lys Val Leu Val Leu Ala Thr Ala Asn Gln Glu Lys 
    610                 615                 620                 


Gly Gln Arg Thr Pro Phe Gln Ala Leu Asp Ser Met Asp Asp Ala Trp 
625                 630                 635                 640 


Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys Glu Ser Lys Leu Leu Gly 
                645                 650                 655     


Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys Ile 
            660                 665                 670         


Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Ile Asp Thr Arg Tyr 
        675                 680                 685             


Ser Ser Arg Val Val Leu Asn Ala Leu Gln Asp Phe Tyr Lys Ala His 
    690                 695                 700                 


Lys Phe Asp Thr Thr Ile Ser Val Val Arg Gly Gln Phe Thr Ser Gln 
705                 710                 715                 720 


Leu Arg Arg Lys Trp Gly Leu Glu Lys Ser Arg Glu Thr Tyr His His 
                725                 730                 735     


His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg Leu 
            740                 745                 750         


Trp Lys Lys Gln Asn Asn Pro Leu Ile Ala Tyr Lys Glu Gly Gln Phe 
        755                 760                 765             


Val Asp Ser Glu Thr Gly Glu Ile Ile Ser Leu Ser Asp Asp Glu Tyr 
    770                 775                 780                 


Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp Thr Leu 
785                 790                 795                 800 


Ser Ser Lys Thr Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Lys Ala Lys Leu Asp Lys Glu Lys Ser Glu Glu Thr Tyr Val Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ser Gln Ala Gly Tyr Asp Ala Phe Ile Lys 
    850                 855                 860                 


Ile Tyr Asn Lys Asp Lys Ser Lys Phe Leu Met Tyr His Lys Asp Pro 
865                 870                 875                 880 


Gln Thr Phe Glu Lys Val Ile Glu Glu Ile Leu Arg Thr Tyr Pro Ser 
                885                 890                 895     


Lys Glu Leu Asn Asp Lys Asn Lys Glu Ile Pro Cys Asn Pro Phe Glu 
            900                 905                 910         


Lys Tyr Arg Gln Glu Asn Gly Pro Ile Arg Lys Tyr Ser Lys Lys Ser 
        915                 920                 925             


Asn Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly 
    930                 935                 940                 


Asn His Ile Asp Ile Thr Pro Glu Ser Ser Asp Asn Gln Val Val Leu 
945                 950                 955                 960 


Gln Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn His Gln Thr 
                965                 970                 975     


Lys Lys Tyr Glu Leu Met Gly Leu Lys Tyr Ser Asp Leu Ser Phe Glu 
            980                 985                 990         


Lys Gly Ser Gly Lys Tyr Ser Ile  Ser Asn Gln Lys Tyr  Asn Ser Ile 
        995                 1000                 1005             


Lys Arg  Ile Glu Gly Ile Asp  Glu Gln Ser Glu Phe  Lys Phe Thr 
    1010                 1015                 1020             


Leu Tyr  Lys Asn Asp Leu Ile  Leu Ile Lys Asp Ser  Glu Asn Asn 
    1025                 1030                 1035             


Glu Gln  Lys Leu Phe Arg Phe  Asn Ser Arg Asn Asp  Thr Ala Lys 
    1040                 1045                 1050             


His Tyr  Ile Glu Leu Lys Pro  Tyr Asp Lys Ala Lys  Phe Asp Gly 
    1055                 1060                 1065             


Glu Gln  Glu Leu Ile Thr Ile  Leu Gly Asn Val Ala  Lys Gly Gly 
    1070                 1075                 1080             


Arg Cys  Leu Lys Gly Leu Asn  Lys Ser Asn Ile Ser  Ile Phe Lys 
    1085                 1090                 1095             


Val Lys  Thr Asp Val Leu Gly  Lys Lys His Ile Ile  Lys Lys Glu 
    1100                 1105                 1110             


Gly Asp  Glu Pro Lys Leu Lys  Phe 
    1115                 1120     


<210> 580
<211> 1375
<212> PRT
<213> Streptococcus sp.


<220>
<223> Streptococcus sp. M334

<400> 580
Met Ser Asn Lys Ser Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Asp Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ser Gln Glu Ile Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Phe Phe Leu Val Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Val Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Ser Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Lys Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Thr Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Lys Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Ala Leu 
                325                 330                 335     


Lys Gln Phe Ile Gln Asn Asn Leu Gln Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Lys Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Ile Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Gln Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Gly Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Gln Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Thr Arg Tyr Gln Phe Leu Asp Lys Lys 
    530                 535                 540                 


Gln Lys Lys Asp Ile Phe Asp Thr Phe Phe Lys Ala Glu Asn Lys Arg 
545                 550                 555                 560 


Lys Val Thr Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly 
                565                 570                 575     


Tyr Asp Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser 
            580                 585                 590         


Leu Ser Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Ala Phe 
        595                 600                 605             


Met Asp Asp Ser Lys Asn Glu Glu Ile Leu Glu Asn Ile Ile His Thr 
    610                 615                 620                 


Leu Thr Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln 
625                 630                 635                 640 


Tyr Asp Ser Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Lys Ser Gly Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Glu Ile Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Glu Ile Ile Gln Lys Ala Gln Val Phe Gly Lys Thr Asn 
705                 710                 715                 720 


Asp Val Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly His Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Ile Glu Asp Ser Leu Lys Asn Leu Ala Ser Gly Leu Asp Ser Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Asn Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Lys Pro 
            820                 825                 830         


Leu Glu Ile Asn Gln Leu Ser Asn Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Ser Lys Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val 
865                 870                 875                 880 


Val Glu Lys Met Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu 
                885                 890                 895     


Ile Ser Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Glu Arg 
            900                 905                 910         


Gly Gly Leu Asn Glu Leu Asp Lys Val Gly Phe Ile Lys Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Phe Leu Asp Ala 
    930                 935                 940                 


Arg Phe Asn Lys Glu Val Thr Glu Lys Asp Lys Lys Asn Arg Asn Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu 
                965                 970                 975     


Phe Gly Leu Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Leu  Ala Lys Ala Ile Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Gln Lys Tyr 
    1010                 1015                 1020             


Asp Leu  Gln Arg Tyr Ile Ser  Lys Ser Arg Glu Pro  Lys Glu Val 
    1025                 1030                 1035             


Glu Lys  Ala Thr Gln Lys Tyr  Phe Phe Tyr Ser Asn  Leu Leu Asn 
    1040                 1045                 1050             


Phe Phe  Lys Glu Glu Val His  Tyr Ala Asp Gly Thr  Ile Val Lys 
    1055                 1060                 1065             


Arg Glu  Asn Ile Glu Tyr Ser  Lys Asp Thr Gly Glu  Ile Ala Trp 
    1070                 1075                 1080             


Asn Lys  Glu Lys Asp Phe Ala  Thr Val Lys Lys Val  Leu Ser Leu 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Thr Lys Glu  Ile Leu Trp Asp Thr  Thr Lys Tyr 
    1130                 1135                 1140             


Gly Gly  Phe Asp Ser Pro Val  Ile Ala Tyr Ser Ile  Leu Leu Ile 
    1145                 1150                 1155             


Ala Asp  Ile Glu Lys Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys 
    1160                 1165                 1170             


Thr Leu  Val Gly Ile Thr Ile  Met Glu Lys Ala Thr  Phe Glu Lys 
    1175                 1180                 1185             


Asn Pro  Ile Thr Phe Leu Glu  Asn Lys Gly Tyr His  Asn Val Arg 
    1190                 1195                 1200             


Lys Glu  Asn Ile Leu Cys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1205                 1210                 1215             


Glu Ser  Gly Arg Arg Arg Met  Leu Ala Ser Ala Lys  Glu Leu Gln 
    1220                 1225                 1230             


Lys Gly  Asn Glu Ile Val Leu  Pro Val Tyr Leu Thr  Thr Leu Leu 
    1235                 1240                 1245             


Tyr His  Ser Lys Asn Val His  Lys Leu Asp Glu Pro  Glu His Leu 
    1250                 1255                 1260             


Glu Tyr  Ile Gln Lys His Arg  Tyr Glu Phe Lys Asp  Leu Leu Asn 
    1265                 1270                 1275             


Leu Val  Ser Glu Phe Ser Gln  Lys Tyr Val Leu Ala  Asp Ala Asn 
    1280                 1285                 1290             


Leu Glu  Lys Ile Lys Asn Leu  Tyr Ala Asp Asn Glu  Gln Ala Asp 
    1295                 1300                 1305             


Ile Glu  Ile Leu Ala Asn Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1310                 1315                 1320             


Ala Leu  Gly Ala Pro Ala Ala  Phe Lys Phe Leu Gly  Lys Asp Val 
    1325                 1330                 1335             


Asp Arg  Lys Arg Tyr Thr Thr  Val Ser Glu Ile Leu  Asn Ala Thr 
    1340                 1345                 1350             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1355                 1360                 1365             


Leu Ser  Lys Leu Gly Glu Asp  
    1370                 1375 


<210> 581
<211> 1371
<212> PRT
<213> Streptococcus sp.


<220>
<223> Streptococcus sp. oral taxon 056 str. F0418

<400> 581
Met Asn Asn Asn Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Arg Val Leu Gly Asn Thr Asp Lys Arg Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Asp Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys 
            100                 105                 110         


Ser Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ala Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Ile Thr Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ala Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Asn Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Gly Lys Ile Ser Lys Ser Val Lys Arg Glu 
    210                 215                 220                 


His Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Ser Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Glu Asp Leu Ala Ala Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Ala Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Leu Leu Lys Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Ser Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Phe Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asn His Lys Asn Gln Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp 
625                 630                 635                 640 


Ser Ile Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Cys Asp 
            660                 665                 670         


Lys Lys Thr Gly Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Tyr 
        675                 680                 685             


Asn Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asp Asp Leu 
705                 710                 715                 720 


Thr Gln Val Val Arg Glu Leu Ser Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Ile Met Gly 
            740                 745                 750         


Tyr Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Lys Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ala Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Thr Ile Ser Lys 
785                 790                 795                 800 


Glu Asn Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asp 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Lys 
865                 870                 875                 880 


Lys Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp 
            900                 905                 910         


Glu Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Ala Arg Phe Asn Thr 
    930                 935                 940                 


Glu Val Ser Glu Lys Asn Gln Lys Ile Arg Ser Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Lys Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Leu Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Lys Ser Lys Asp  Pro Lys Glu Val Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Thr Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Val Thr Ile Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Arg Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Pro Lys Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Asp Ile Leu Trp Asp  Thr Thr Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Val Ile Ala Tyr Ser  Ile Leu Leu Ile Ala  Asp Ile Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ala Lys Lys Leu  Lys Thr Val Lys Thr  Leu Val Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Lys Ala  Ala Phe Glu Lys Asn  Pro Ile Thr 
    1175                 1180                 1185             


Phe Leu  Glu Asn Lys Gly Tyr  His Asn Val Arg Lys  Glu Asn Ile 
    1190                 1195                 1200             


Leu Cys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Ile Val  Leu Pro Val Tyr Leu  Thr Thr Leu Leu Tyr  His Ser Lys 
    1235                 1240                 1245             


Asn Val  His Lys Leu Asp Glu  Pro Glu His Leu Glu  Tyr Ile Gln 
    1250                 1255                 1260             


Lys His  Arg Tyr Glu Phe Lys  Asp Leu Leu Asn Leu  Val Ser Glu 
    1265                 1270                 1275             


Phe Ser  Gln Lys Tyr Val Leu  Ala Glu Ala Asn Leu  Glu Lys Ile 
    1280                 1285                 1290             


Lys Ser  Leu Tyr Val Asp Asn  Glu Gln Ala Asp Ile  Glu Ile Leu 
    1295                 1300                 1305             


Ala Asn  Ser Phe Ile Asn Leu  Leu Thr Phe Thr Ala  Leu Gly Ala 
    1310                 1315                 1320             


Pro Ala  Ala Phe Lys Phe Phe  Gly Lys Asp Val Asp  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Thr  Thr Val Ser Glu Ile  Leu Asn Ala Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1355                 1360                 1365             


Gly Glu  Asp 
    1370     


<210> 582
<211> 1420
<212> PRT
<213> Streptococcus sp.


<220>
<223> Streptococcus sp. oral taxon 071 str. 73H25AP

<400> 582
Met Ala Lys Phe Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Val 
1               5                   10                  15      


Ser Ser Val Gly Tyr Ala Val Val Thr Glu Asp Tyr Arg Val Pro Ala 
            20                  25                  30          


Phe Lys Phe Lys Val Leu Gly Asn Thr Glu Lys Glu Lys Ile Lys Lys 
        35                  40                  45              


Asn Leu Ile Gly Ser Thr Thr Phe Val Pro Ala Gln Ser Ala Gln Gly 
    50                  55                  60                  


Thr Arg Val Phe Arg Val Asn Arg Arg Arg Ile Asp Arg Arg Asn His 
65                  70                  75                  80  


Arg Ile Ala Tyr Leu Arg Asp Ile Phe Gln Lys Glu Ile Glu Lys Ile 
                85                  90                  95      


Asp Lys Asn Phe Tyr Arg Arg Leu Asp Glu Ser Phe Arg Val Leu Gly 
            100                 105                 110         


Asp Lys Ser Glu Asp Ile Gln Ile Lys Gln Pro Phe Phe Gly Asn Lys 
        115                 120                 125             


Glu Leu Glu Thr Ala Tyr His Lys Lys Tyr Pro Thr Ile Tyr His Leu 
    130                 135                 140                 


Arg Lys His Leu Ala Asp Ala Asp Lys Asn Ser Pro Val Ala Asp Ile 
145                 150                 155                 160 


Arg Glu Val Tyr Met Val Leu Ser His Ile Leu Lys Tyr Arg Gly His 
                165                 170                 175     


Phe Leu Thr Leu Gly Lys Ile Asp Pro Asn Asn Ile Asn Met Gln Asn 
            180                 185                 190         


Ser Trp Ile Asp Phe Ile Glu Ser Cys Gln Asp Ala Phe Asp Leu Glu 
        195                 200                 205             


Ile Ser Asp Glu Ser Lys Thr Ile Ala Ala Ile Phe Lys Ser Ser Glu 
    210                 215                 220                 


Asn Arg Gln Glu Lys Val Lys Gln Ile Leu Ser Tyr Phe Gln Gln Glu 
225                 230                 235                 240 


Leu Leu Lys Lys Asp Lys Ser Ile Phe Lys Gln Leu Leu Gln Leu Leu 
                245                 250                 255     


Phe Gly Leu Lys Thr Lys Phe Lys Asp Cys Phe Glu Leu Glu Glu Glu 
            260                 265                 270         


Pro Asp Leu Asn Phe Ser Lys Glu Asn Tyr Asp Glu Asn Leu Glu Asn 
        275                 280                 285             


Leu Leu Gly Ala Leu Glu Glu Asp Phe Ser Asp Val Phe Ala Lys Leu 
    290                 295                 300                 


Lys Ile Leu Arg Asp Thr Ile Leu Leu Ser Ser Met Leu Thr Tyr Thr 
305                 310                 315                 320 


Gly Ala Thr His Ala Arg Phe Ser Ala Thr Met Val Glu Arg Tyr Glu 
                325                 330                 335     


Glu His Arg Lys Asp Leu Gln Arg Phe Lys Ser Phe Val Lys Gln Asn 
            340                 345                 350         


Leu Ser Glu Gln Asp Tyr Leu Asp Ile Phe Gly Arg Lys Thr Pro Thr 
        355                 360                 365             


Gly Phe Asp Val Asp Lys Glu Thr Lys Gly Tyr Val Gly Tyr Ile Ser 
    370                 375                 380                 


Asn Lys Met Val Leu Thr Asn Pro Gln Lys Gln Lys Thr Ile Gln Gln 
385                 390                 395                 400 


Asn Phe Tyr Asp Tyr Ile Ser Gly Lys Ile Thr Gly Ile Glu Gly Ala 
                405                 410                 415     


Glu Cys Phe Leu Asn Lys Ile Ser Asp Gly Thr Phe Leu Arg Lys Leu 
            420                 425                 430         


Arg Thr Thr Asp Asn Gly Ala Ile Pro Asn Gln Ile His Ala Tyr Glu 
        435                 440                 445             


Leu Glu Lys Ile Ile Glu Arg Gln Gly Arg Asp Tyr Pro Phe Leu Leu 
    450                 455                 460                 


Glu Asn Lys Asp Lys Leu Leu Ser Ile Leu Thr Phe Lys Ile Pro Tyr 
465                 470                 475                 480 


Tyr Val Gly Pro Leu Ala Lys Gly Asn Asn Ser Arg Phe Ala Trp Ile 
                485                 490                 495     


Lys Arg Thr Thr Ser Gln Asp Val Leu Asp Asp Asn Asp Glu Asp Thr 
            500                 505                 510         


Arg Asn Gly Lys Ile Arg Pro Trp Asn Tyr His Lys Leu Ile Asn Met 
        515                 520                 525             


Asp Glu Thr Arg Asp Ala Phe Ile Ile Asn Leu Ile Gly Asn Asp Ile 
    530                 535                 540                 


Ile Leu Leu Asn Glu Lys Val Leu Pro Lys Arg Ser Leu Ile Tyr Glu 
545                 550                 555                 560 


Glu Val Met Leu Gln Asn Glu Leu Thr Arg Val Lys Tyr Lys Asp Lys 
                565                 570                 575     


Tyr Gly Lys Ile His Phe Phe Asn Ser Glu Leu Arg Gln Glu Ile Ile 
            580                 585                 590         


Asn Asn Leu Phe Lys Thr Asn Ser Lys Arg Val Ser Ser Ala Met Leu 
        595                 600                 605             


Leu Ser Tyr Leu Glu Asn Phe Thr Asn Leu Gln Ala Val Glu Ile Val 
    610                 615                 620                 


Ser Gly Ile Glu Lys Gly Lys Ser Leu Asn Ser Thr Leu Lys Thr Tyr 
625                 630                 635                 640 


Asn Asp Leu Lys Thr Ile Phe Ser Glu Glu Leu Leu Asp Ser Glu Ile 
                645                 650                 655     


Tyr Gln Lys Glu Leu Glu Glu Ile Ile Lys Val Ile Thr Val Phe Asp 
            660                 665                 670         


Asp Lys Lys Ser Ile Lys Asn Tyr Leu Thr Lys Tyr Phe Gly His Leu 
        675                 680                 685             


Glu Phe Leu Asn Glu Glu Lys Ile Asn Gln Leu Ser Lys Leu Arg Tyr 
    690                 695                 700                 


Thr Gly Trp Gly Arg Tyr Ser Gly Lys Leu Leu Leu Gly Ile Arg Asp 
705                 710                 715                 720 


Glu Asp Thr Gly Phe Asn Leu Met Gln Phe Leu Arg Asn Asp Asp Glu 
                725                 730                 735     


Asn Arg Asn Leu Thr Gln Leu Ile Ser Asp Thr Thr Leu Ser Phe Asp 
            740                 745                 750         


Ser Ala Ile Lys Ala Ile Gln Ser Lys Ser Thr Val Glu Asp Asp Val 
        755                 760                 765             


Phe Glu Glu Ile Lys Asn Leu Ala Gly Ser Pro Ala Ile Lys Arg Gly 
    770                 775                 780                 


Ile Leu Asn Ser Ile Lys Ile Val Asp Glu Leu Val Gln Ile Ile Gly 
785                 790                 795                 800 


Tyr Pro Pro Gln Asn Ile Ile Ile Glu Met Ala Arg Glu Asn Met Thr 
                805                 810                 815     


Thr Glu Glu Gly Gln Lys Lys Ala Lys Thr Arg Lys Ser Lys Leu Glu 
            820                 825                 830         


Ser Ala Leu Lys Asn Ile Glu Asp Ser Val Leu Glu Ser Gly Lys Val 
        835                 840                 845             


Pro His Ser Asp Glu Gln Leu Gln Ser Glu Lys Leu Tyr Leu Tyr Tyr 
    850                 855                 860                 


Leu Gln Asn Gly Lys Asp Met Tyr Ser Leu Asp Lys Thr Gly Ser Pro 
865                 870                 875                 880 


Thr Pro Leu Tyr Arg Asp Gln Leu Asp Gln Tyr Glu Val Asp His Ile 
                885                 890                 895     


Ile Pro Tyr Ser Phe Leu Pro Ile Asp Ser Ile Asp Asn Lys Val Leu 
            900                 905                 910         


Thr His Arg Glu Asn Asn Gln Arg Lys Leu Asn Asn Ile Pro Asp Lys 
        915                 920                 925             


Glu Thr Val Ala Asn Met Lys Pro Phe Trp Glu Lys Leu Tyr Asn Ala 
    930                 935                 940                 


Lys Leu Ile Ser Gln Thr Lys Tyr Gln Arg Leu Thr Thr Ser Glu Arg 
945                 950                 955                 960 


Thr Pro Asp Gly Val Leu Thr Glu Ser Met Lys Ala Gly Phe Ile Glu 
                965                 970                 975     


Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Lys His Val Ala Arg Ile 
            980                 985                 990         


Leu Asp Asn Arg Phe Ser Asp Thr  Lys Ile Ile Thr Leu  Lys Ser Gln 
        995                 1000                 1005             


Leu Val  Thr Asn Phe Arg Asn  Thr Phe His Ile Ala  Lys Ile Arg 
    1010                 1015                 1020             


Glu Leu  Asn Asp Tyr His His  Ala His Asp Ala Tyr  Leu Ala Val 
    1025                 1030                 1035             


Val Val  Gly Gln Thr Leu Leu  Lys Ala Tyr Pro Lys  Leu Ala Pro 
    1040                 1045                 1050             


Glu Leu  Ile Tyr Gly His His  Ala His Phe Asn Arg  His Glu Glu 
    1055                 1060                 1065             


Asn Lys  Ala Thr Leu Arg Lys  His Leu Tyr Ser Asn  Ile Met Arg 
    1070                 1075                 1080             


Phe Phe  Asn Asn Pro Asp Ser  Lys Val Ser Lys Asp  Ile Trp Asp 
    1085                 1090                 1095             


Cys Asn  Arg Asp Leu Pro Ile  Val Lys Asp Val Ile  Tyr Asn Ser 
    1100                 1105                 1110             


Gln Ile  Asn Phe Val Lys Arg  Thr Met Ile Lys Lys  Gly Ala Phe 
    1115                 1120                 1125             


Tyr Asn  Gln Asn Pro Val Gly  Lys Leu Asn Lys Gln  Ile Ala Ala 
    1130                 1135                 1140             


Asn Asn  Arg Tyr Pro Leu Lys  Thr Lys Val Ser Ser  Leu Asp Thr 
    1145                 1150                 1155             


Ser Ile  Tyr Gly Gly Tyr Gly  Pro Met Asn Ser Ala  Leu Ser Ile 
    1160                 1165                 1170             


Ile Ile  Ile Ala Glu Arg Phe  Asn Glu Lys Lys Gly  Lys Ile Glu 
    1175                 1180                 1185             


Thr Val  Lys Glu Phe His Asp  Ile Phe Ile Ile Asp  Tyr Glu Lys 
    1190                 1195                 1200             


Phe Asn  Asn Asn Pro Phe Gln  Phe Leu Asn Asn Val  Ser Glu Glu 
    1205                 1210                 1215             


Gly Phe  Leu Lys Lys Asn Asp  Leu Asn Arg Val Leu  Ala Phe Tyr 
    1220                 1225                 1230             


Arg Ile  Ser Lys Tyr Ser Leu  Met Gln Lys Ile Asp  Gly Thr Arg 
    1235                 1240                 1245             


Met Leu  Phe Glu Ser Lys Ser  Asn Leu His Lys Val  Thr Gln Phe 
    1250                 1255                 1260             


Lys Leu  Thr Lys Thr Gln Asn  Glu Leu Phe Phe His  Met Lys Arg 
    1265                 1270                 1275             


Leu Leu  Thr Lys Ser Asn Leu  Met Asp Leu Lys Ser  Glu Ser Ala 
    1280                 1285                 1290             


Ile Lys  Glu Ser Gln Asn Phe  Ile Gln Thr His Gln  Asn Glu Phe 
    1295                 1300                 1305             


Asp Asn  Ile Ala Asp Arg Leu  Ser Asn Tyr Ser Gln  Lys Met Leu 
    1310                 1315                 1320             


Gly Glu  Thr Lys Ser Leu Gln  Thr Leu Ile Asn Gly  Tyr Asn Glu 
    1325                 1330                 1335             


Arg Pro  Ile Lys Gln Ile Asp  Asn Asn Glu Glu Thr  Ile Arg Tyr 
    1340                 1345                 1350             


Tyr Tyr  Asp Asn Phe Ile Lys  Met Phe Ser Phe Val  Lys Ser Gly 
    1355                 1360                 1365             


Ala Pro  Lys Asp Ile Ile Asn  Phe Phe Asn Asp Lys  Tyr Thr Val 
    1370                 1375                 1380             


Pro Arg  Met Arg Pro Lys Pro  Asp Arg Lys Met Leu  Asp Ala Thr 
    1385                 1390                 1395             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1400                 1405                 1410             


Leu Ser  Lys Leu Gly Glu Asp  
    1415                 1420 


<210> 583
<211> 1122
<212> PRT
<213> Streptococcus suis


<220>
<223> Streptococcus suis 89/1591

<400> 583
Met Ser Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Val Ile Asp Ala Gln Thr Gly Glu Ile Ile His Ala Ser 
            20                  25                  30          


Ser Arg Ile Phe Pro Ser Ala Asn Ala Ala Asn Asn Ala Glu Arg Arg 
        35                  40                  45              


Thr Phe Arg Gly Ser Arg Arg Leu Ile Arg Arg Lys Lys His Arg Ile 
    50                  55                  60                  


Lys Arg Leu Asp Asp Leu Phe Asn Asp Phe His Ile Asn Leu Asp Gly 
65                  70                  75                  80  


Glu Met Ser Thr Asp Asn Pro Tyr Val Leu Arg Val Lys Gly Leu Ser 
                85                  90                  95      


Gln Lys Leu Thr Val Glu Glu Leu Tyr Ile Ser Ile Lys Asn Ile Met 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Ser Asp Asn Glu 
        115                 120                 125             


Ala Gly Arg Ser Asp Tyr Ala Lys Ala Ile Glu Arg Asn Arg Gln Leu 
    130                 135                 140                 


Leu Thr Ser Lys Thr Pro Gly Glu Ile Gln Leu Glu Arg Leu Glu Lys 
145                 150                 155                 160 


Tyr Gly Gln Leu Arg Gly Asn Phe Thr Ile Ile Asp Glu Glu Gly Gln 
                165                 170                 175     


Ser Gln Gln Ile Ile Asn Val Phe Ser Thr Ser Asp Tyr Val Lys Glu 
            180                 185                 190         


Val Glu Lys Ile Leu Asp Cys Gln Lys Met Tyr His Lys Phe Ile Ser 
        195                 200                 205             


Asp Glu Phe Cys Asp Lys Leu Ile Glu Leu Leu Arg Glu Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile 
225                 230                 235                 240 


Tyr Arg Thr Asp Gly Thr Thr Leu Glu Asn Leu Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Gln Tyr Arg Ser Ser Arg Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Phe Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Gln Glu Gln Lys Glu Phe Leu 
    290                 295                 300                 


Val Asn Tyr Ala Lys Glu Thr Ser Val Leu Gly Ala Gly Lys Ile Leu 
305                 310                 315                 320 


Gln Gln Ile Ala Lys Leu Ala Asp Cys Lys Val Glu Asp Ile Arg Gly 
                325                 330                 335     


Tyr Arg Leu Asp Asn Lys Asp Lys Pro Glu Leu His Thr Phe Glu Thr 
            340                 345                 350         


Tyr Arg Ala Met Lys Gly Leu Val Pro Leu Val Asp Ile Gly Val Leu 
        355                 360                 365             


Ser Arg Glu Gln Leu Asp Ile Leu Ala Asp Ile Leu Thr Leu Asn Thr 
    370                 375                 380                 


Asp Phe Glu Gly Ile Arg Glu Ala Leu Lys Lys Gln Leu Pro Asn Val 
385                 390                 395                 400 


Phe Asp Glu Lys Gln Val Lys Gly Leu Ala Ser Phe Arg Lys Ser Lys 
                405                 410                 415     


Ser Gln Leu Phe Ala Lys Gly Trp His Asn Leu Ser Gln Lys Ile Met 
            420                 425                 430         


Leu Glu Val Ile Pro Glu Leu Tyr Ala Thr Ser Asp Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Phe Glu Lys Ser Ser Val Ala Glu Tyr 
    450                 455                 460                 


Pro Ser Ser Ile Asn Val Asp Glu Ile Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Ile Arg Gln Thr Ile Lys Ile Ile Asn Ala Ser 
                485                 490                 495     


Ile Lys Lys Trp Gly Glu Phe Asp Gln Ile Val Ile Glu Met Pro Arg 
            500                 505                 510         


Asp Arg Asn Glu Asp Glu Glu Lys Lys Arg Ile Ala Asp Gly Gln Lys 
        515                 520                 525             


Ala Asn Ala Lys Glu Lys Ala Asp Ser Ile Leu Arg Ala Ala Glu Leu 
    530                 535                 540                 


Tyr Cys Ala Gly Lys Val Leu Pro Asp Tyr Val Tyr Asn Gly His Asn 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Ile Tyr Thr Gly Gln Pro Ile Ser Ile His Asp Leu Ile His Asn Gln 
            580                 585                 590         


Asn Gln Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ser Asn Lys Val Leu Val Leu Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Ala Gln Arg Thr Pro Tyr Asn Tyr Leu Lys Ser Ala Thr Ser Ala 
625                 630                 635                 640 


Trp Ser Tyr Arg Glu Phe Lys Asp Tyr Val Thr Lys Arg Lys Gly Ile 
                645                 650                 655     


Gly Lys Lys Lys Cys Glu Tyr Leu Thr Phe Glu Glu Asp Ile Asn Gly 
            660                 665                 670         


Phe Glu Val Arg Ser Lys Phe Ile Gln Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Lys Val Ile Leu Asn Ala Leu Gln Asp Tyr Phe Lys Ile 
    690                 695                 700                 


Ser Gly Ile Gln Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg His Lys Trp Gly Ile Glu Lys Thr Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg 
            740                 745                 750         


Leu Trp Lys Lys Gln Glu Ser Pro Leu Val Val Asp Tyr Gln Glu Gly 
        755                 760                 765             


Arg Gln Val Asp Leu Glu Thr Gly Glu Ile Leu Glu Leu Thr Asp Glu 
    770                 775                 780                 


Gln Tyr Lys Glu Leu Val Tyr Gln Pro Pro Tyr Gln Gly Phe Val Asn 
785                 790                 795                 800 


Thr Ile Ser Ser Ser Ala Phe Asp Asn Glu Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Val Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala 
            820                 825                 830         


Thr Arg Asn Ala Gln Leu Gly Lys Asp Lys Thr Glu Gly Ile Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Thr Gln Ala Gly Tyr Glu Ala Phe 
    850                 855                 860                 


Leu Lys Arg Tyr Thr Lys Asp Lys Thr Ser Phe Leu Met Tyr His Lys 
865                 870                 875                 880 


Asp Leu Asp Thr Trp Glu Lys Val Ile Glu Ile Ile Leu Arg Asp Tyr 
                885                 890                 895     


Arg Glu Tyr Asp Glu Lys Gly Lys Glu Ile Gly Asn Pro Phe Glu Arg 
            900                 905                 910         


Tyr Arg Arg Glu Asn Gly Tyr Val Lys Lys Tyr Ser Arg Lys Gly Asn 
        915                 920                 925             


Gly Thr Ala Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Glu Asn Ser Arg Asn Ala Val Val Leu Gln 
945                 950                 955                 960 


Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Lys Glu Thr Gly 
                965                 970                 975     


Lys Tyr Glu Phe Leu Gly Ile Lys Tyr Ser Asp Leu Ser Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Glu Tyr Gly Ile Ser  Gln Glu Lys Tyr Asp  Ser Ile Lys 
        995                 1000                 1005             


Ile Ala  Glu Gly Val Ala Lys  Lys Ser Ile Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Gln Asp Leu Leu Phe  Ile Lys Asp Ile Glu  Asn Asn Phe 
    1025                 1030                 1035             


Gly Lys  Leu Leu Arg Phe Thr  Ser Lys Asn Asp Thr  Ser Lys His 
    1040                 1045                 1050             


Tyr Val  Glu Leu Lys Pro Tyr  Asp Lys Asn Lys Phe  Gly Thr Glu 
    1055                 1060                 1065             


Glu Pro  Leu Leu Pro Val Leu  Gly Asn Val Ala Lys  Ser Gly Gln 
    1070                 1075                 1080             


Cys Ile  Lys Gly Leu Asn Lys  Ser Asn Ile Ser Ile  Tyr Lys Val 
    1085                 1090                 1095             


Arg Thr  Asp Ile Leu Gly Tyr  Arg His Phe Ile Lys  Gln Glu Gly 
    1100                 1105                 1110             


Glu His  Pro Gln Leu Lys Phe  Lys Lys 
    1115                 1120         


<210> 584
<211> 1122
<212> PRT
<213> Streptococcus suis

<400> 584
Met Ser Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Val Ile Asp Ala Gln Thr Gly Glu Ile Ile His Ala Ser 
            20                  25                  30          


Ser Arg Ile Phe Pro Ser Ala Asn Ala Ala Asn Asn Ala Glu Arg Arg 
        35                  40                  45              


Thr Phe Arg Gly Ser Arg Arg Leu Ile Arg Arg Lys Lys His Arg Ile 
    50                  55                  60                  


Lys Arg Leu Asp Asp Leu Phe Asn Asp Phe His Ile Asn Leu Asp Gly 
65                  70                  75                  80  


Glu Met Ser Thr Asp Asn Pro Tyr Val Leu Arg Val Lys Gly Leu Ser 
                85                  90                  95      


Gln Lys Leu Thr Val Glu Glu Leu Tyr Ile Ser Ile Lys Asn Ile Met 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Ser Asp Asn Glu 
        115                 120                 125             


Ala Gly Arg Ser Asp Tyr Ala Lys Ala Ile Glu Arg Asn Arg Gln Leu 
    130                 135                 140                 


Leu Thr Ser Lys Thr Pro Gly Glu Ile Gln Leu Glu Arg Leu Glu Lys 
145                 150                 155                 160 


Tyr Gly Gln Leu Arg Gly Asn Phe Thr Ile Ile Asp Glu Glu Gly Gln 
                165                 170                 175     


Ser Gln Gln Ile Ile Asn Val Phe Ser Thr Ser Asp Tyr Val Lys Glu 
            180                 185                 190         


Val Glu Lys Ile Leu Asp Cys Gln Lys Met Tyr His Lys Phe Ile Ser 
        195                 200                 205             


Asp Glu Phe Cys Asp Lys Leu Ile Glu Leu Leu Arg Glu Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile 
225                 230                 235                 240 


Tyr Arg Thr Asp Gly Thr Thr Leu Glu Asn Leu Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Gln Tyr Arg Ser Ser Arg Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Phe Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Gln Glu Gln Lys Glu Phe Leu 
    290                 295                 300                 


Val Asn Tyr Ala Lys Glu Thr Ser Val Leu Gly Ala Gly Lys Ile Leu 
305                 310                 315                 320 


Gln Gln Ile Ala Lys Leu Ala Asp Cys Lys Val Glu Asp Ile Arg Gly 
                325                 330                 335     


Tyr Arg Leu Asp Asn Lys Asp Lys Pro Glu Leu His Thr Phe Glu Thr 
            340                 345                 350         


Tyr Arg Ala Met Lys Gly Leu Val Pro Leu Val Asp Ile Gly Val Leu 
        355                 360                 365             


Ser Arg Glu Gln Leu Asp Ile Leu Ala Asp Ile Leu Thr Leu Asn Thr 
    370                 375                 380                 


Asp Phe Glu Gly Ile Arg Glu Ala Leu Lys Lys Gln Leu Pro Asn Val 
385                 390                 395                 400 


Phe Asp Glu Lys Gln Val Lys Gly Leu Ala Ser Phe Arg Lys Ser Lys 
                405                 410                 415     


Ser Gln Leu Phe Ala Lys Gly Trp His Asn Leu Ser Gln Lys Ile Met 
            420                 425                 430         


Leu Glu Val Ile Pro Glu Leu Tyr Ala Thr Ser Asp Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Phe Glu Lys Ser Ser Val Ala Glu Tyr 
    450                 455                 460                 


Pro Ser Ser Ile Asn Val Asp Glu Ile Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Ile Arg Gln Thr Ile Lys Ile Ile Asn Ala Ser 
                485                 490                 495     


Ile Lys Lys Trp Asp Glu Phe Asp Gln Ile Val Ile Glu Met Pro Arg 
            500                 505                 510         


Asp Arg Asn Glu Asp Glu Glu Lys Lys Arg Ile Ala Asp Gly Gln Lys 
        515                 520                 525             


Ala Asn Ala Lys Glu Lys Ala Asp Ser Ile Leu Arg Ala Ala Glu Leu 
    530                 535                 540                 


Tyr Cys Ala Gly Lys Val Leu Pro Asp Tyr Val Tyr Asn Gly His Asn 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Ile Tyr Thr Gly Gln Pro Ile Ser Ile His Asp Leu Ile His Asn Gln 
            580                 585                 590         


Asn Gln Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ser Asn Lys Val Leu Val Leu Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Ala Gln Arg Thr Pro Tyr Asn Tyr Leu Lys Ser Ala Thr Ser Ala 
625                 630                 635                 640 


Trp Ser Tyr Arg Glu Phe Lys Asp Tyr Val Thr Lys Arg Lys Gly Ile 
                645                 650                 655     


Gly Lys Lys Lys Cys Glu Tyr Leu Thr Phe Glu Glu Asp Ile Asn Gly 
            660                 665                 670         


Phe Glu Val Arg Ser Lys Phe Ile Gln Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Lys Val Ile Leu Asn Ala Leu Gln Asp Tyr Phe Lys Ile 
    690                 695                 700                 


Ser Gly Ile Gln Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg His Lys Trp Gly Ile Glu Lys Thr Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg 
            740                 745                 750         


Leu Trp Lys Lys Gln Glu Ser Pro Leu Val Val Asp Tyr Gln Glu Gly 
        755                 760                 765             


Arg Gln Val Asp Leu Glu Thr Gly Glu Ile Leu Glu Leu Thr Asp Glu 
    770                 775                 780                 


Gln Tyr Lys Glu Leu Val Tyr Gln Pro Pro Tyr Gln Gly Phe Val Asn 
785                 790                 795                 800 


Thr Ile Ser Ser Ser Ala Phe Asp Asn Glu Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Val Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala 
            820                 825                 830         


Thr Arg Asn Ala Gln Leu Gly Lys Asp Lys Thr Glu Gly Ile Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Thr Gln Ala Gly Tyr Glu Ala Phe 
    850                 855                 860                 


Leu Lys Arg Tyr Thr Lys Asp Lys Thr Ser Phe Leu Met Tyr His Lys 
865                 870                 875                 880 


Asp Leu Asp Thr Trp Glu Lys Val Ile Glu Ile Ile Leu Arg Asp Tyr 
                885                 890                 895     


Arg Glu Tyr Asp Glu Lys Gly Lys Glu Ile Gly Asn Pro Phe Glu Arg 
            900                 905                 910         


Tyr Arg Arg Glu Asn Gly Tyr Val Lys Lys Tyr Ser Arg Lys Gly Asn 
        915                 920                 925             


Gly Thr Ala Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Glu Asn Ser Arg Asn Ala Val Val Leu Gln 
945                 950                 955                 960 


Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Lys Glu Thr Gly 
                965                 970                 975     


Lys Tyr Glu Phe Leu Gly Ile Lys Tyr Ser Asp Leu Ser Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Glu Tyr Gly Ile Ser  Gln Glu Lys Tyr Asp  Ser Ile Lys 
        995                 1000                 1005             


Ile Ala  Glu Gly Val Ala Lys  Lys Ser Ile Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Gln Asp Leu Leu Phe  Ile Lys Asp Ile Glu  Asn Asn Phe 
    1025                 1030                 1035             


Gly Lys  Leu Leu Arg Phe Thr  Ser Lys Asn Asp Thr  Ser Lys His 
    1040                 1045                 1050             


Tyr Val  Glu Leu Lys Pro Tyr  Asp Lys Asn Lys Phe  Gly Thr Glu 
    1055                 1060                 1065             


Glu Pro  Leu Leu Pro Val Leu  Gly Asn Val Ala Lys  Ser Gly Gln 
    1070                 1075                 1080             


Cys Ile  Lys Gly Leu Asn Lys  Ser Asn Ile Ser Ile  Tyr Lys Val 
    1085                 1090                 1095             


Arg Thr  Asp Ile Leu Gly Tyr  Arg His Phe Ile Lys  Gln Glu Gly 
    1100                 1105                 1110             


Glu His  Pro Gln Leu Lys Phe  Lys Lys 
    1115                 1120         


<210> 585
<211> 1381
<212> PRT
<213> Streptococcus suis

<400> 585
Met Val Lys Lys Lys Tyr Ala Ile Gly Ile Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ser Ile Val Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Phe Gly Asn Thr Glu Lys Arg Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Thr Leu Leu Phe Asp Glu Gly Asn Thr Ala Glu Asn Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Glu Ile Phe Ala Glu Glu Ile Asn Lys Ile Asp Asp 
                85                  90                  95      


Ser Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Ile Val Glu Asp Lys 
            100                 105                 110         


Gln Gly Ser Lys His Pro Ile Phe Gly Thr Leu Gln Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Ser Gln Lys Ala Asp Ile Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Ile Ile Lys Tyr Arg Gly His Phe Leu Phe Glu Gly Asp Leu Lys 
                165                 170                 175     


Ser Glu Asn Lys Asp Val Gln His Leu Phe Asn Asp Phe Val Glu Met 
            180                 185                 190         


Phe Asp Lys Thr Val Glu Gly Ser Tyr Leu Ser Glu Asn Leu Pro Asn 
        195                 200                 205             


Val Ala Asp Val Leu Val Glu Lys Val Ser Lys Ser Arg Arg Leu Glu 
    210                 215                 220                 


Asn Ile Leu His Tyr Phe Pro Asn Glu Lys Lys Asn Gly Leu Phe Gly 
225                 230                 235                 240 


Asn Phe Leu Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn 
                245                 250                 255     


Phe Glu Leu Ala Glu Asp Ala Lys Ile Gln Phe Ser Lys Glu Thr Tyr 
            260                 265                 270         


Glu Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala 
        275                 280                 285             


Asp Leu Phe Ile Ala Thr Lys Ser Leu Tyr Asp Gly Ile Leu Leu Ala 
    290                 295                 300                 


Gly Ile Leu Ser Thr Thr Asp Ser Thr Thr Lys Ala Pro Leu Ser Ser 
305                 310                 315                 320 


Ser Met Val Asn Arg Tyr Glu Glu His Gln Lys Asp Leu Ala Leu Leu 
                325                 330                 335     


Lys Asn Phe Ile His Gln Asn Leu Ser Asp Ser Tyr Lys Glu Val Phe 
            340                 345                 350         


Asn Asp Lys Leu Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Asn Phe Tyr Arg Phe Ile Lys Lys Ala Ile Glu Lys Ile 
    370                 375                 380                 


Glu Gly Ser Asn Tyr Phe Ile Asp Lys Ile Asp Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met His Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro 
            420                 425                 430         


Phe Leu Val Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Glu Phe Ala 
    450                 455                 460                 


Trp Leu Asn Arg Lys Ser Asp Glu Lys Ile Arg Pro Trp Asn Phe Asp 
465                 470                 475                 480 


Glu Met Val Asp Lys Glu Thr Ser Ala Glu Asn Phe Ile Thr Arg Met 
                485                 490                 495     


Thr Asn Tyr Asp Arg Tyr Leu Pro Asp Gln Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Lys Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Met Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Asp Ile Val Lys Thr Leu Phe Lys Thr Lys Arg Lys Val 
545                 550                 555                 560 


Thr Ala Lys Asp Ile Lys Ala Tyr Leu Glu Asn Ser Asn Gly Tyr Ala 
                565                 570                 575     


Gly Val Glu Leu Lys Gly Leu Glu Glu Gln Phe Asn Ala Ser Leu Pro 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Leu Arg Asp Lys Ala Phe Ile Asp 
        595                 600                 605             


Ala Glu Glu Asn Gln Glu Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Lys Tyr Lys 
625                 630                 635                 640 


Asp Ile Leu Thr Glu Glu Gln Arg Lys Lys Leu Glu Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Leu Asp 
            660                 665                 670         


Lys Val Thr Arg Lys Thr Ile Leu Gly Tyr Leu Ile Asp Asp Gly Thr 
        675                 680                 685             


Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Thr Leu Ser Phe 
    690                 695                 700                 


Val Asp Glu Ile Arg Leu Ala Gln Gly Ser Gly Glu Ala Glu Asp Tyr 
705                 710                 715                 720 


Arg Ala Glu Val Gln Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Ile Glu Val Met Gly 
            740                 745                 750         


Tyr Glu Pro Glu His Ile Val Val Glu Met Ala Arg Glu Asn Gln Phe 
        755                 760                 765             


Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Ile Asn Arg Leu Glu 
    770                 775                 780                 


Asn Ala Leu Lys Asp Phe Gly Ser Lys Ile Leu Glu Glu Gln Lys Pro 
785                 790                 795                 800 


Tyr Gly Val Ser Lys Val Asn Asn Ile His Leu Gln Ser Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Glu Glu 
            820                 825                 830         


Leu Asp Ile Asp His Leu Ser Glu Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Leu Asp Asn Lys Val Leu Thr Lys 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Met Glu Ile 
865                 870                 875                 880 


Val His Asn Arg Lys Asn Phe Trp Arg Gln Leu Leu Lys Ser Lys Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Asn Glu Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Met Leu Asp Thr Arg Phe 
    930                 935                 940                 


Asn Thr Lys Leu Asp Glu Ala Gly Asn Arg Ile Arg Asp Pro Lys Val 
945                 950                 955                 960 


Asn Ile Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Tyr Gln Leu Tyr Lys Ile Arg Glu Ile Asn Asn Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Ile Asn Ala Val Val  Ala Thr Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Gln  Leu Ala Pro Glu Phe  Val Tyr Gly Glu Tyr  Pro Thr Tyr 
    1010                 1015                 1020             


Asn Ser  Tyr Asn Ser Arg Lys  Ser Ala Thr Glu Lys  Val Leu Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Arg Ile Val  Val His Ser 
    1040                 1045                 1050             


Lys Thr  Gly Glu Val Arg Ile  Arg Pro Val Ile Glu  Val Asn Lys 
    1055                 1060                 1065             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Lys Ser Asp  Phe Arg Thr 
    1070                 1075                 1080             


Val Arg  Lys Val Leu Ser Tyr  Pro Gln Val Asn Val  Val Lys Lys 
    1085                 1090                 1095             


Thr Glu  Val Gln Asn His Gly  Leu Asp Arg Gly Lys  Pro Lys Gly 
    1100                 1105                 1110             


Phe Tyr  Asn Ala Asn Leu Ser  Pro Arg Pro Lys Glu  Gly Ser Val 
    1115                 1120                 1125             


Glu Asn  Leu Val Pro Ala Lys  Gln Ser Phe Asp Thr  Lys Arg Tyr 
    1130                 1135                 1140             


Gly Gly  Tyr Ala Gly Ile Ser  Asn Ser Tyr Ala Val  Leu Val Asn 
    1145                 1150                 1155             


Gly Ile  Ile Glu Lys Gly Lys  Lys Lys Ser Lys Ala  Glu Val Thr 
    1160                 1165                 1170             


Glu Phe  Gln Gly Ile Ser Ile  Leu Ala Arg Lys Asp  Phe Asp Lys 
    1175                 1180                 1185             


Asn Pro  Lys Gln Tyr Leu Leu  Asn Leu Gly Tyr Lys  Asp Ile Lys 
    1190                 1195                 1200             


Ser Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn 
    1205                 1210                 1215             


Gly Ser  Arg Arg Met Leu Ala  Ser Ile Leu Ser Thr  Asn Asn Lys 
    1220                 1225                 1230             


Arg Gly  Glu Ile His Lys Gly  Asn Glu Met Tyr Leu  Pro Asp Lys 
    1235                 1240                 1245             


Phe Val  Thr Leu Leu Tyr His  Ala Met Arg Val Asn  Arg Thr Leu 
    1250                 1255                 1260             


Glu Pro  Gly His Lys Lys Tyr  Val Glu Thr His Arg  His Val Phe 
    1265                 1270                 1275             


Asp Glu  Leu Leu Ile Tyr Ile  Leu Glu Tyr Asn Glu  Lys Ile Val 
    1280                 1285                 1290             


Gly Ala  Lys Ala Asn Gly Lys  Arg Ile Val Glu Ala  Tyr Ser Ala 
    1295                 1300                 1305             


Arg Lys  Asp Thr Asp Asn Leu  Glu Glu Leu Cys Asn  Ser Phe Ile 
    1310                 1315                 1320             


Asn Leu  Leu Asn Leu Thr Ala  Leu Gly Ser Ala Val  Asp Phe Glu 
    1325                 1330                 1335             


Phe Leu  Gly Thr Lys Ile Pro  Arg Tyr Arg Asp Tyr  Thr Pro Ser 
    1340                 1345                 1350             


Ser Leu  Leu Lys Ala Thr Leu  Ile His Gln Ser Val  Thr Gly Leu 
    1355                 1360                 1365             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu Gly Gly  Asp 
    1370                 1375                 1380     


<210> 586
<211> 1122
<212> PRT
<213> Streptococcus suis

<400> 586
Met Ser Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Val Ile Asp Ala Gln Thr Gly Glu Ile Ile His Ala Ser 
            20                  25                  30          


Ser Arg Ile Phe Pro Ser Ala Asn Ala Ala Asn Asn Ala Glu Arg Arg 
        35                  40                  45              


Thr Phe Arg Gly Ser Arg Arg Leu Ile Arg Arg Lys Lys His Arg Ile 
    50                  55                  60                  


Lys Arg Leu Asp Asp Leu Phe Asn Asp Phe His Ile Asn Leu Asp Gly 
65                  70                  75                  80  


Glu Met Ser Thr Asp Asn Pro Tyr Val Leu Arg Val Lys Gly Leu Ser 
                85                  90                  95      


Gln Lys Leu Thr Val Glu Glu Leu Tyr Ile Ser Ile Lys Asn Ile Met 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Ser Asp Asn Glu 
        115                 120                 125             


Ala Gly Arg Ser Asp Tyr Ala Lys Ala Ile Glu Arg Asn Arg Gln Leu 
    130                 135                 140                 


Leu Thr Ser Lys Thr Pro Gly Glu Ile Gln Leu Glu Arg Leu Glu Lys 
145                 150                 155                 160 


Tyr Gly Gln Leu Arg Gly Asn Phe Thr Ile Ile Asp Glu Glu Gly Gln 
                165                 170                 175     


Ser Gln Gln Ile Ile Asn Val Phe Ser Thr Ser Asp Tyr Val Lys Glu 
            180                 185                 190         


Val Glu Lys Ile Leu Asp Cys Gln Lys Met Tyr His Lys Phe Ile Ser 
        195                 200                 205             


Asp Glu Phe Cys Asp Lys Leu Ile Glu Leu Leu Arg Glu Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile 
225                 230                 235                 240 


Tyr Arg Thr Asp Gly Thr Thr Leu Glu Asn Leu Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Gln Tyr Arg Ser Ser Arg Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Phe Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Gln Glu Gln Lys Glu Phe Leu 
    290                 295                 300                 


Val Asn Tyr Ala Lys Glu Thr Ser Val Leu Gly Ala Gly Lys Ile Leu 
305                 310                 315                 320 


Gln Gln Ile Ala Lys Leu Ala Asp Cys Lys Val Glu Asp Ile Arg Gly 
                325                 330                 335     


Tyr Arg Leu Asp Asn Lys Asp Lys Pro Glu Leu His Thr Phe Glu Thr 
            340                 345                 350         


Tyr Arg Ala Met Lys Gly Leu Val Pro Leu Val Asp Ile Gly Val Leu 
        355                 360                 365             


Ser Arg Glu Gln Leu Asp Ile Leu Ala Asp Ile Leu Thr Leu Asn Thr 
    370                 375                 380                 


Asp Phe Glu Gly Ile Arg Glu Ala Leu Lys Lys Gln Leu Pro Asn Val 
385                 390                 395                 400 


Phe Asp Glu Lys Gln Val Lys Gly Leu Ala Ser Phe Arg Lys Ser Lys 
                405                 410                 415     


Ser Gln Leu Phe Ala Lys Gly Trp His Asn Leu Ser Gln Lys Ile Met 
            420                 425                 430         


Leu Glu Val Ile Pro Glu Leu Tyr Ala Thr Ser Asp Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Phe Glu Lys Ser Ser Val Ala Glu Tyr 
    450                 455                 460                 


Pro Ser Ser Ile Asn Val Asp Glu Ile Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Ile Arg Gln Thr Ile Lys Ile Ile Asn Ala Ser 
                485                 490                 495     


Ile Lys Lys Trp Gly Glu Phe Asp Gln Ile Val Ile Glu Met Pro Arg 
            500                 505                 510         


Asp Arg Asn Glu Asp Glu Glu Lys Lys Arg Ile Ala Asp Gly Gln Lys 
        515                 520                 525             


Ala Asn Ala Lys Glu Lys Ala Asp Ser Ile Leu Arg Ala Ala Glu Leu 
    530                 535                 540                 


Tyr Cys Ala Gly Lys Val Leu Pro Asp Tyr Val Tyr Asn Gly His Asn 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Ile Tyr Thr Gly Gln Pro Ile Ser Ile His Asp Leu Ile His Asn Gln 
            580                 585                 590         


Asn Gln Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ser Asn Lys Val Leu Val Leu Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Ala Gln Arg Thr Pro Tyr Asn Tyr Leu Lys Ser Ala Thr Ser Ala 
625                 630                 635                 640 


Trp Ser Tyr Arg Glu Phe Lys Asp Tyr Val Thr Lys Arg Lys Gly Ile 
                645                 650                 655     


Gly Lys Lys Lys Cys Glu Tyr Leu Thr Phe Glu Glu Asp Ile Asn Gly 
            660                 665                 670         


Phe Glu Val Arg Ser Lys Phe Ile Gln Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Lys Val Ile Leu Asn Ala Leu Gln Asp Tyr Phe Lys Ile 
    690                 695                 700                 


Ser Gly Ile Gln Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg His Lys Trp Gly Ile Glu Lys Thr Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg 
            740                 745                 750         


Leu Trp Lys Lys Gln Glu Ser Pro Leu Val Val Asp Tyr Gln Glu Gly 
        755                 760                 765             


Arg Gln Val Asp Leu Glu Thr Gly Glu Ile Leu Glu Leu Thr Asp Glu 
    770                 775                 780                 


Gln Tyr Lys Glu Leu Val Tyr Gln Pro Pro Tyr Gln Gly Phe Val Asn 
785                 790                 795                 800 


Thr Ile Ser Ser Ser Ala Phe Asp Asn Glu Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Val Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala 
            820                 825                 830         


Thr Arg Asn Ala Gln Leu Gly Lys Asp Lys Thr Glu Gly Ile Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Thr Gln Ala Gly Tyr Glu Ala Phe 
    850                 855                 860                 


Leu Lys Arg Tyr Thr Lys Asp Lys Thr Ser Phe Leu Met Tyr His Lys 
865                 870                 875                 880 


Asp Leu Asp Thr Trp Glu Lys Val Ile Glu Ile Ile Leu Arg Asp Tyr 
                885                 890                 895     


Arg Glu Tyr Asp Glu Lys Gly Lys Glu Ile Gly Asn Pro Phe Glu Arg 
            900                 905                 910         


Tyr Arg Arg Glu Asn Gly Tyr Val Lys Lys Tyr Ser Arg Lys Gly Asn 
        915                 920                 925             


Gly Thr Ala Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Glu Asn Ser Arg Asn Ala Val Val Leu Gln 
945                 950                 955                 960 


Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Lys Glu Thr Gly 
                965                 970                 975     


Lys Tyr Glu Phe Leu Gly Ile Lys Tyr Ser Asp Leu Ser Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Glu Tyr Gly Ile Ser  Gln Glu Lys Tyr Asp  Ser Ile Lys 
        995                 1000                 1005             


Ile Ala  Glu Gly Val Ala Lys  Lys Ser Ile Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Gln Asp Leu Leu Phe  Ile Lys Asp Ile Glu  Asn Asn Phe 
    1025                 1030                 1035             


Gly Lys  Leu Leu Arg Phe Thr  Ser Lys Asn Asp Thr  Ser Lys His 
    1040                 1045                 1050             


Tyr Val  Glu Leu Lys Pro Tyr  Asp Lys Asn Lys Phe  Gly Thr Glu 
    1055                 1060                 1065             


Glu Pro  Leu Leu Pro Val Leu  Gly Asn Val Ala Lys  Ser Gly Gln 
    1070                 1075                 1080             


Cys Ile  Lys Gly Leu Asn Lys  Ser Asn Ile Ser Ile  Tyr Lys Val 
    1085                 1090                 1095             


Arg Thr  Asp Ile Leu Gly Tyr  Arg His Phe Ile Lys  Gln Glu Gly 
    1100                 1105                 1110             


Glu His  Pro Gln Leu Lys Phe  Lys Lys 
    1115                 1120         


<210> 587
<211> 1388
<212> PRT
<213> Streptococcus thermophilus

<400> 587
Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asn Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Val Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Cys Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Asn Leu Leu Ala Glu Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Glu Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp Glu Asp Lys Gly Asn 
705                 710                 715                 720 


Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg 
    770                 775                 780                 


Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 
785                 790                 795                 800 


Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Phe Pro Ser Leu 
865                 870                 875                 880 


Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr Gln Leu Leu Lys Ser 
                885                 890                 895     


Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Leu Pro Glu Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu 
    930                 935                 940                 


Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg Ala Val Arg Thr Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Phe His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Ile  Ala Ser Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Pro Lys Tyr 
    1010                 1015                 1020             


Asn Ser  Phe Arg Glu Arg Lys  Ser Ala Thr Glu Lys  Val Tyr Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Ile  Phe Lys Lys Ser Ile  Ser Leu Ala 
    1040                 1045                 1050             


Asp Gly  Arg Val Ile Glu Arg  Pro Leu Ile Glu Val  Asn Glu Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ser Val Trp Asn  Lys Glu Ser Asp Leu  Ala Thr Val 
    1070                 1075                 1080             


Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Glu  Gln Asn His Gly Leu  Asp Arg Gly Lys Pro  Lys Gly Leu 
    1100                 1105                 1110             


Phe Asn  Ala Asn Leu Ser Ser  Lys Pro Lys Pro Asn  Ser Asn Glu 
    1115                 1120                 1125             


Asn Leu  Val Gly Ala Lys Glu  Tyr Leu Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Gly Ile Ser Asn  Ser Phe Ala Val Leu  Val Lys Gly 
    1145                 1150                 1155             


Thr Ile  Glu Lys Gly Ala Lys  Lys Lys Ile Thr Asn  Val Leu Glu 
    1160                 1165                 1170             


Phe Gln  Gly Ile Ser Ile Leu  Asp Arg Ile Asn Tyr  Arg Lys Asp 
    1175                 1180                 1185             


Lys Leu  Asn Phe Leu Leu Glu  Lys Gly Tyr Lys Asp  Ile Glu Leu 
    1190                 1195                 1200             


Ile Ile  Glu Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Ser Asp Gly 
    1205                 1210                 1215             


Ser Arg  Arg Met Leu Ala Ser  Ile Leu Ser Thr Asn  Asn Lys Arg 
    1220                 1225                 1230             


Gly Glu  Ile His Lys Gly Asn  Gln Ile Phe Leu Ser  Gln Lys Phe 
    1235                 1240                 1245             


Val Lys  Leu Leu Tyr His Ala  Lys Arg Ile Ser Asn  Thr Ile Asn 
    1250                 1255                 1260             


Glu Asn  His Arg Lys Tyr Val  Glu Asn His Lys Lys  Glu Phe Glu 
    1265                 1270                 1275             


Glu Leu  Phe Tyr Tyr Ile Leu  Glu Phe Asn Glu Asn  Tyr Val Gly 
    1280                 1285                 1290             


Ala Lys  Lys Asn Gly Lys Leu  Leu Asn Ser Ala Phe  Gln Ser Trp 
    1295                 1300                 1305             


Gln Asn  His Ser Ile Asp Glu  Leu Cys Ser Ser Phe  Ile Gly Pro 
    1310                 1315                 1320             


Thr Gly  Ser Glu Arg Lys Gly  Leu Phe Glu Leu Thr  Ser Arg Gly 
    1325                 1330                 1335             


Ser Ala  Ala Asp Phe Glu Phe  Leu Gly Val Lys Ile  Pro Arg Tyr 
    1340                 1345                 1350             


Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Lys Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ala 
    1370                 1375                 1380             


Lys Leu  Gly Glu Gly 
    1385             


<210> 588
<211> 1128
<212> PRT
<213> Streptococcus thermophilus

<400> 588
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Ile Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Glu Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Arg Leu Arg Leu Gln Ile Lys 
    450                 455                 460                 


Gln Asn Ile Ser Asn Lys Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr 
465                 470                 475                 480 


Glu Glu Ile Tyr Asn Pro Val Val Ala Lys Ser Val Arg Gln Ala Ile 
                485                 490                 495     


Lys Ile Val Asn Ala Ala Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile 
            500                 505                 510         


Val Ile Glu Met Ala Arg Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala 
        515                 520                 525             


Ile Gln Lys Ile Gln Lys Ala Asn Lys Asp Glu Lys Asp Ala Ala Met 
    530                 535                 540                 


Leu Lys Ala Ala Asn Gln Tyr Asn Gly Lys Ala Glu Leu Pro His Ser 
545                 550                 555                 560 


Val Phe His Gly His Lys Gln Leu Ala Thr Lys Ile Arg Leu Trp His 
                565                 570                 575     


Gln Gln Gly Glu Arg Cys Leu Tyr Thr Gly Lys Thr Ile Ser Ile His 
            580                 585                 590         


Asp Leu Ile Asn Asn Pro Asn Gln Phe Glu Val Asp His Ile Leu Pro 
        595                 600                 605             


Leu Ser Ile Thr Phe Asp Asp Ser Leu Ala Asn Lys Val Leu Val Tyr 
    610                 615                 620                 


Ala Thr Ala Asn Gln Glu Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu 
625                 630                 635                 640 


Asp Ser Met Asp Asp Ala Trp Ser Phe Arg Glu Leu Lys Ala Phe Val 
                645                 650                 655     


Arg Glu Ser Lys Thr Leu Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr 
            660                 665                 670         


Glu Glu Asp Ile Ser Lys Phe Asp Val Arg Lys Lys Phe Ile Glu Arg 
        675                 680                 685             


Asn Leu Val Asp Thr Arg Tyr Ala Ser Arg Val Val Leu Asn Ala Leu 
    690                 695                 700                 


Gln Glu His Phe Arg Ala His Lys Ile Asp Thr Lys Val Ser Val Val 
705                 710                 715                 720 


Arg Gly Gln Phe Thr Ser Gln Leu Arg Arg His Trp Gly Ile Glu Lys 
                725                 730                 735     


Thr Arg Asp Thr Tyr His His His Ala Val Asp Ala Leu Ile Ile Ala 
            740                 745                 750         


Ala Ser Ser Gln Leu Asn Leu Trp Lys Lys Gln Lys Asn Thr Leu Val 
        755                 760                 765             


Ser Tyr Ser Glu Glu Gln Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile 
    770                 775                 780                 


Ser Asp Asp Glu Tyr Lys Glu Ser Val Phe Lys Ala Pro Tyr Gln His 
785                 790                 795                 800 


Phe Val Asp Thr Leu Lys Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe 
                805                 810                 815     


Ser Tyr Gln Val Asp Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr 
            820                 825                 830         


Ile Tyr Ala Thr Arg Gln Ala Lys Val Gly Lys Asp Lys Lys Asp Glu 
        835                 840                 845             


Thr Tyr Val Leu Gly Lys Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr 
    850                 855                 860                 


Asp Ala Phe Met Lys Ile Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met 
865                 870                 875                 880 


Tyr Arg His Asp Pro Gln Thr Phe Glu Lys Val Ile Glu Pro Ile Leu 
                885                 890                 895     


Glu Asn Tyr Pro Asn Lys Gln Met Asn Glu Lys Gly Lys Glu Val Pro 
            900                 905                 910         


Cys Asn Pro Phe Leu Lys Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys 
        915                 920                 925             


Tyr Ser Lys Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr 
    930                 935                 940                 


Asp Ser Lys Leu Leu Gly Asn Pro Ile Asp Ile Thr Pro Glu Asn Ser 
945                 950                 955                 960 


Lys Asn Lys Val Val Leu Gln Ser Leu Lys Pro Trp Arg Thr Asp Val 
                965                 970                 975     


Tyr Phe Asn Lys Ala Thr Gly Lys Tyr Glu Ile Leu Gly Leu Lys Tyr 
            980                 985                 990         


Ala Asp Leu Gln Phe Glu Lys Gly  Thr Gly Thr Tyr Lys  Ile Ser Gln 
        995                 1000                 1005             


Glu Lys  Tyr Asn Asp Ile Lys  Lys Lys Glu Gly Val  Asp Ser Asp 
    1010                 1015                 1020             


Ser Glu  Phe Lys Phe Thr Leu  Tyr Lys Asn Asp Leu  Leu Leu Val 
    1025                 1030                 1035             


Lys Asp  Thr Glu Thr Lys Glu  Gln Gln Leu Phe Arg  Phe Leu Ser 
    1040                 1045                 1050             


Arg Thr  Leu Pro Lys Gln Lys  His Tyr Val Glu Leu  Lys Pro Tyr 
    1055                 1060                 1065             


Asp Lys  Gln Lys Phe Glu Gly  Gly Glu Ala Leu Ile  Lys Val Leu 
    1070                 1075                 1080             


Gly Asn  Val Ala Asn Gly Gly  Gln Cys Ile Lys Gly  Leu Ala Lys 
    1085                 1090                 1095             


Ser Asn  Ile Ser Ile Tyr Lys  Val Arg Thr Asp Val  Leu Gly Asn 
    1100                 1105                 1110             


Gln His  Ile Ile Lys Asn Glu  Gly Asp Lys Pro Lys  Leu Asp Phe 
    1115                 1120                 1125             


<210> 589
<211> 1121
<212> PRT
<213> Streptococcus thermophilus

<400> 589
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Ile Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Glu 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ile Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Ala Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Gln Ile Asn Glu Lys Gly Lys Glu Val Pro Val Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln 
945                 950                 955                 960 


Ser Val Ser Pro Trp Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr Gly 
                965                 970                 975     


Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Thr Tyr Lys Ile Ser  Gln Glu Lys Tyr Asn  Asp Ile Lys 
        995                 1000                 1005             


Lys Lys  Glu Gly Val Asp Ser  Asp Ser Glu Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Asn Asp Leu Leu Leu  Val Lys Asp Thr Glu  Thr Lys Glu 
    1025                 1030                 1035             


Gln Gln  Leu Phe Arg Phe Leu  Ser Arg Thr Met Pro  Lys Gln Lys 
    1040                 1045                 1050             


His Tyr  Val Glu Leu Lys Pro  Tyr Asp Lys Gln Lys  Phe Glu Gly 
    1055                 1060                 1065             


Gly Glu  Ala Leu Ile Lys Val  Leu Gly Asn Val Ala  Asn Ser Gly 
    1070                 1075                 1080             


Gln Cys  Lys Lys Gly Leu Gly  Lys Ser Asn Ile Ser  Ile Tyr Lys 
    1085                 1090                 1095             


Val Arg  Thr Asp Val Leu Gly  Asn Gln His Ile Ile  Lys Asn Glu 
    1100                 1105                 1110             


Gly Asp  Lys Pro Lys Leu Asp  Phe 
    1115                 1120     


<210> 590
<211> 1388
<212> PRT
<213> Streptococcus thermophilus

<400> 590
Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Thr Thr Asp Asn Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Ala Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Cys Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Lys Leu Leu Ala Glu Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Glu Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp Glu Asp Lys Gly Asn 
705                 710                 715                 720 


Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg 
    770                 775                 780                 


Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 
785                 790                 795                 800 


Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu 
865                 870                 875                 880 


Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr Gln Leu Leu Lys Ser 
                885                 890                 895     


Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Ser Pro Glu Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu 
    930                 935                 940                 


Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg Ala Val Arg Thr Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Phe His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Val  Ala Ser Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Pro Lys Tyr 
    1010                 1015                 1020             


Asn Ser  Phe Arg Glu Arg Lys  Ser Ala Thr Glu Lys  Val Tyr Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Ile  Phe Lys Lys Ser Ile  Ser Leu Ala 
    1040                 1045                 1050             


Asp Gly  Arg Val Ile Glu Arg  Pro Leu Ile Glu Val  Asn Glu Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ser Val Trp Asn  Lys Glu Ser Asp Leu  Ala Thr Val 
    1070                 1075                 1080             


Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Glu  Gln Asn His Gly Leu  Asp Arg Gly Lys Pro  Lys Gly Leu 
    1100                 1105                 1110             


Phe Asn  Ala Asn Leu Ser Ser  Lys Pro Lys Pro Asn  Ser Asn Glu 
    1115                 1120                 1125             


Asn Leu  Val Gly Ala Lys Glu  Tyr Leu Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Gly Ile Ser Asn  Ser Phe Thr Val Leu  Val Lys Gly 
    1145                 1150                 1155             


Thr Ile  Glu Lys Gly Ala Lys  Lys Lys Ile Thr Asn  Val Leu Glu 
    1160                 1165                 1170             


Phe Gln  Gly Ile Ser Ile Leu  Asp Arg Ile Asn Tyr  Arg Lys Asp 
    1175                 1180                 1185             


Lys Leu  Asn Phe Leu Leu Glu  Lys Gly Tyr Lys Asp  Ile Glu Leu 
    1190                 1195                 1200             


Ile Ile  Glu Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Ser Asp Gly 
    1205                 1210                 1215             


Ser Arg  Arg Met Leu Ala Ser  Ile Leu Ser Thr Asn  Asn Lys Arg 
    1220                 1225                 1230             


Gly Glu  Ile His Lys Gly Asn  Gln Ile Phe Leu Ser  Gln Lys Phe 
    1235                 1240                 1245             


Val Lys  Leu Leu Tyr His Ala  Lys Arg Ile Ser Asn  Thr Ile Asn 
    1250                 1255                 1260             


Glu Asn  His Arg Lys Tyr Val  Glu Asn His Lys Lys  Glu Phe Glu 
    1265                 1270                 1275             


Glu Leu  Phe Tyr Tyr Ile Leu  Glu Phe Asn Glu Asn  Tyr Val Gly 
    1280                 1285                 1290             


Ala Lys  Lys Asn Gly Lys Leu  Leu Asn Ser Ala Phe  Gln Ser Trp 
    1295                 1300                 1305             


Gln Asn  His Ser Ile Asp Glu  Leu Cys Ser Ser Phe  Ile Gly Pro 
    1310                 1315                 1320             


Thr Gly  Ser Glu Arg Lys Gly  Leu Phe Glu Leu Thr  Ser Arg Gly 
    1325                 1330                 1335             


Ser Ala  Ala Asp Phe Glu Phe  Leu Gly Val Lys Ile  Pro Arg Tyr 
    1340                 1345                 1350             


Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Lys Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ala 
    1370                 1375                 1380             


Lys Leu  Gly Glu Gly 
    1385             


<210> 591
<211> 1121
<212> PRT
<213> Streptococcus thermophilus

<400> 591
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Ala Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Ala Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Gln Ile Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln 
945                 950                 955                 960 


Ser Val Ser Pro Trp Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr Gly 
                965                 970                 975     


Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Thr Tyr Lys Ile Ser  Gln Glu Lys Tyr Asn  Asp Ile Lys 
        995                 1000                 1005             


Lys Lys  Glu Gly Val Asp Ser  Asp Ser Glu Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Asn Asp Leu Leu Leu  Val Lys Asp Thr Glu  Thr Lys Glu 
    1025                 1030                 1035             


Gln Gln  Leu Phe Arg Phe Leu  Ser Arg Thr Met Pro  Lys Gln Lys 
    1040                 1045                 1050             


His Tyr  Val Glu Leu Lys Pro  Tyr Asp Lys Gln Lys  Phe Glu Gly 
    1055                 1060                 1065             


Gly Glu  Ala Leu Ile Lys Val  Leu Gly Asn Val Ala  Asn Ser Gly 
    1070                 1075                 1080             


Gln Cys  Lys Lys Gly Leu Gly  Lys Ser Asn Ile Ser  Ile Tyr Lys 
    1085                 1090                 1095             


Val Arg  Thr Asp Val Leu Gly  Asn Gln His Ile Ile  Lys Asn Glu 
    1100                 1105                 1110             


Gly Asp  Lys Pro Lys Leu Asp  Phe 
    1115                 1120     


<210> 592
<211> 1122
<212> PRT
<213> Streptococcus thermophilus

<400> 592
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Ile Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Ser Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Asn Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Val Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


His Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Pro 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Glu Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Lys Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Glu Met Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Leu Gly 
    930                 935                 940                 


Asn Pro Ile Asp Ile Thr Pro Glu Asn Ser Lys Asn Lys Val Val Leu 
945                 950                 955                 960 


Gln Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Lys Asn Thr 
                965                 970                 975     


Gly Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu 
            980                 985                 990         


Lys Lys Thr Gly Thr Tyr Lys Ile  Ser Gln Glu Lys Tyr  Asn Gly Ile 
        995                 1000                 1005             


Met Lys  Glu Glu Gly Val Asp  Ser Asp Ser Glu Phe  Lys Phe Thr 
    1010                 1015                 1020             


Leu Tyr  Lys Asn Asp Leu Leu  Leu Val Lys Asp Thr  Glu Thr Lys 
    1025                 1030                 1035             


Glu Gln  Gln Leu Phe Arg Phe  Leu Ser Arg Thr Met  Pro Asn Val 
    1040                 1045                 1050             


Lys Tyr  Tyr Val Glu Leu Lys  Pro Tyr Ser Lys Asp  Lys Phe Glu 
    1055                 1060                 1065             


Lys Asn  Glu Ser Leu Ile Glu  Ile Leu Gly Ser Ala  Asp Lys Ser 
    1070                 1075                 1080             


Gly Arg  Cys Ile Lys Gly Leu  Gly Lys Ser Asn Ile  Ser Ile Tyr 
    1085                 1090                 1095             


Lys Val  Arg Thr Asp Val Leu  Gly Asn Gln His Ile  Ile Lys Asn 
    1100                 1105                 1110             


Glu Gly  Asp Lys Pro Lys Leu  Asp Phe 
    1115                 1120         


<210> 593
<211> 1388
<212> PRT
<213> Streptococcus thermophilus

<400> 593
Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asn Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Ala Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Cys Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Asn Leu Leu Ala Glu Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Glu Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp Glu Asp Lys Gly Asn 
705                 710                 715                 720 


Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg 
    770                 775                 780                 


Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 
785                 790                 795                 800 


Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Phe Pro Ser Leu 
865                 870                 875                 880 


Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr Gln Leu Leu Lys Ser 
                885                 890                 895     


Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Leu Pro Glu Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu 
    930                 935                 940                 


Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg Ala Val Arg Thr Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Phe His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Ile  Ala Ser Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Pro Lys Tyr 
    1010                 1015                 1020             


Asn Ser  Phe Arg Glu Arg Lys  Ser Ala Thr Glu Lys  Val Tyr Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Ile  Phe Lys Lys Ser Ile  Ser Leu Ala 
    1040                 1045                 1050             


Asp Gly  Arg Val Ile Glu Arg  Pro Leu Ile Glu Val  Asn Glu Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ser Val Trp Asn  Lys Glu Ser Asp Leu  Ala Thr Val 
    1070                 1075                 1080             


Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Glu  Gln Asn His Gly Leu  Asp Arg Gly Lys Pro  Lys Gly Leu 
    1100                 1105                 1110             


Phe Asn  Ala Asn Leu Ser Ser  Lys Pro Lys Pro Asn  Ser Asn Glu 
    1115                 1120                 1125             


Asn Leu  Val Gly Ala Lys Glu  Tyr Leu Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Gly Ile Ser Asn  Ser Phe Ala Val Leu  Val Lys Gly 
    1145                 1150                 1155             


Thr Ile  Glu Lys Gly Ala Lys  Lys Lys Ile Thr Asn  Val Leu Glu 
    1160                 1165                 1170             


Phe Gln  Gly Ile Ser Ile Leu  Asp Arg Ile Asn Tyr  Arg Lys Asp 
    1175                 1180                 1185             


Lys Leu  Asn Phe Leu Leu Glu  Lys Gly Tyr Lys Asp  Ile Glu Leu 
    1190                 1195                 1200             


Ile Ile  Glu Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Ser Asp Gly 
    1205                 1210                 1215             


Ser Arg  Arg Met Leu Ala Ser  Ile Leu Ser Thr Asn  Asn Lys Arg 
    1220                 1225                 1230             


Gly Glu  Ile His Lys Gly Asn  Gln Ile Phe Leu Ser  Gln Lys Phe 
    1235                 1240                 1245             


Val Lys  Leu Leu Tyr His Ala  Lys Arg Ile Ser Asn  Thr Ile Asn 
    1250                 1255                 1260             


Glu Asn  His Arg Lys Tyr Val  Glu Asn His Lys Lys  Glu Phe Glu 
    1265                 1270                 1275             


Glu Leu  Phe Tyr Tyr Ile Leu  Glu Phe Asn Glu Asn  Tyr Val Gly 
    1280                 1285                 1290             


Ala Lys  Lys Asn Gly Lys Leu  Leu Asn Ser Ala Phe  Gln Ser Trp 
    1295                 1300                 1305             


Gln Asn  His Ser Ile Asp Glu  Leu Cys Ser Ser Phe  Ile Gly Pro 
    1310                 1315                 1320             


Thr Gly  Ser Glu Arg Lys Gly  Leu Phe Glu Leu Thr  Ser Arg Gly 
    1325                 1330                 1335             


Ser Ala  Ala Asp Phe Glu Phe  Leu Gly Val Lys Ile  Pro Arg Tyr 
    1340                 1345                 1350             


Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Lys Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ala 
    1370                 1375                 1380             


Lys Leu  Gly Glu Gly 
    1385             


<210> 594
<211> 1121
<212> PRT
<213> Streptococcus thermophilus

<400> 594
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Val Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Asn Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Glu Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Lys Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Ile Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Pro 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Lys Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Glu Met Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Asp Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln 
945                 950                 955                 960 


Ser Val Ser Pro Trp Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr Gly 
                965                 970                 975     


Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Thr Tyr Lys Ile Ser  Gln Glu Lys Tyr Asn  Asp Ile Lys 
        995                 1000                 1005             


Lys Lys  Glu Gly Val Asp Ser  Asp Ser Glu Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Asn Asp Leu Leu Leu  Val Lys Asp Thr Glu  Thr Lys Glu 
    1025                 1030                 1035             


Gln Gln  Leu Phe Arg Phe Leu  Ser Arg Thr Met Pro  Lys Gln Lys 
    1040                 1045                 1050             


His Tyr  Val Glu Leu Lys Pro  Tyr Asp Lys Gln Lys  Phe Glu Gly 
    1055                 1060                 1065             


Gly Glu  Ala Leu Ile Lys Val  Leu Gly Asn Val Ala  Asn Ser Gly 
    1070                 1075                 1080             


Gln Cys  Lys Lys Gly Leu Gly  Lys Ser Asn Ile Ser  Ile Tyr Lys 
    1085                 1090                 1095             


Val Arg  Thr Asp Val Leu Gly  Asn Gln His Ile Ile  Lys Asn Glu 
    1100                 1105                 1110             


Gly Asp  Lys Pro Lys Leu Asp  Phe 
    1115                 1120     


<210> 595
<211> 1122
<212> PRT
<213> Streptococcus thermophilus


<220>
<223> Streptococcus thermophilus MTCC 5460

<400> 595
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Val Glu Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Arg Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Ser Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Glu Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Ser 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Pro 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Leu Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Lys Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Glu Met Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Leu Gly 
    930                 935                 940                 


Asn Pro Ile Asp Ile Thr Pro Glu Asn Ser Lys Asn Lys Val Val Leu 
945                 950                 955                 960 


Gln Ser Leu Lys Pro Trp Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr 
                965                 970                 975     


Gly Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu 
            980                 985                 990         


Lys Lys Thr Gly Thr Tyr Lys Ile  Ser Gln Glu Lys Tyr  Asn Gly Ile 
        995                 1000                 1005             


Met Lys  Glu Glu Gly Val Asp  Ser Asp Ser Glu Phe  Lys Phe Thr 
    1010                 1015                 1020             


Leu Tyr  Lys Asn Asp Leu Leu  Leu Val Lys Asp Thr  Glu Thr Lys 
    1025                 1030                 1035             


Glu Gln  Gln Leu Phe Arg Phe  Leu Ser Arg Thr Met  Pro Asn Val 
    1040                 1045                 1050             


Lys Tyr  Tyr Val Glu Leu Lys  Pro Tyr Ser Lys Asp  Lys Phe Glu 
    1055                 1060                 1065             


Lys Asn  Glu Ser Leu Ile Glu  Ile Leu Gly Ser Ala  Asp Lys Ser 
    1070                 1075                 1080             


Gly Arg  Cys Ile Lys Gly Leu  Gly Lys Ser Asn Ile  Ser Ile Tyr 
    1085                 1090                 1095             


Lys Val  Arg Thr Asp Val Leu  Gly Asn Gln His Ile  Ile Lys Asn 
    1100                 1105                 1110             


Glu Gly  Asp Lys Pro Lys Leu  Asp Phe 
    1115                 1120         


<210> 596
<211> 1121
<212> PRT
<213> Streptococcus thermophilus

<400> 596
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Ile Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Ala Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Gln Met Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln 
945                 950                 955                 960 


Ser Val Ser Pro Trp Arg Ala Asp Ile Tyr Phe Asn Asn Thr Thr Gly 
                965                 970                 975     


Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Thr Tyr Lys Ile Ser  Gln Glu Lys Tyr Asn  Asp Ile Lys 
        995                 1000                 1005             


Lys Lys  Glu Gly Val Asp Ser  Asp Ser Glu Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Asn Asp Leu Leu Leu  Val Lys Glu Thr Glu  Thr Lys Glu 
    1025                 1030                 1035             


Gln Gln  Leu Phe Arg Phe Leu  Ser Arg Thr Met Pro  Lys Gln Lys 
    1040                 1045                 1050             


His Tyr  Val Glu Leu Lys Pro  Tyr Asp Lys Gln Lys  Phe Glu Gly 
    1055                 1060                 1065             


Gly Glu  Ala Leu Ile Lys Val  Leu Gly Asn Val Ala  Asn Gly Gly 
    1070                 1075                 1080             


Gln Cys  Ile Lys Gly Leu Gly  Lys Ser Asn Ile Ser  Ile Tyr Lys 
    1085                 1090                 1095             


Val Arg  Thr Asp Val Leu Gly  Asn Gln His Ile Ile  Lys Asn Glu 
    1100                 1105                 1110             


Gly Asp  Lys Pro Lys Leu Asp  Phe 
    1115                 1120     


<210> 597
<211> 1388
<212> PRT
<213> Streptococcus thermophilus

<400> 597
Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asn Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Ala Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Cys Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Asn Leu Leu Ala Glu Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Glu Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp Glu Asp Lys Gly Asn 
705                 710                 715                 720 


Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg 
    770                 775                 780                 


Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 
785                 790                 795                 800 


Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Phe Pro Ser Leu 
865                 870                 875                 880 


Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr Gln Leu Leu Lys Ser 
                885                 890                 895     


Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Leu Pro Glu Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu 
    930                 935                 940                 


Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg Ala Val Arg Thr Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Phe Glu Leu Tyr Lys Val Cys Glu Ile Asn Asp Phe His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Ile  Ala Ser Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Pro Lys Tyr 
    1010                 1015                 1020             


Asn Ser  Phe Arg Glu Arg Lys  Ser Ala Thr Glu Lys  Val Tyr Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Ile  Phe Lys Lys Ser Ile  Ser Leu Ala 
    1040                 1045                 1050             


Asp Gly  Arg Val Ile Glu Arg  Pro Leu Ile Glu Val  Asn Glu Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ser Val Trp Asn  Lys Glu Ser Asp Leu  Ala Thr Val 
    1070                 1075                 1080             


Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Glu  Gln Asn His Gly Leu  Asp Arg Gly Lys Pro  Lys Gly Leu 
    1100                 1105                 1110             


Phe Asn  Ala Asn Leu Ser Ser  Lys Pro Lys Pro Asn  Ser Asn Glu 
    1115                 1120                 1125             


Asn Leu  Val Gly Ala Lys Glu  Tyr Leu Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Gly Ile Ser Asn  Ser Phe Ala Val Leu  Val Lys Gly 
    1145                 1150                 1155             


Thr Ile  Glu Lys Gly Ala Lys  Lys Lys Ile Thr Asn  Val Leu Glu 
    1160                 1165                 1170             


Phe Gln  Gly Ile Ser Ile Leu  Asp Arg Ile Asn Tyr  Arg Lys Asp 
    1175                 1180                 1185             


Lys Leu  Asn Phe Leu Leu Glu  Lys Gly Tyr Lys Asp  Ile Glu Leu 
    1190                 1195                 1200             


Ile Ile  Glu Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Ser Asp Gly 
    1205                 1210                 1215             


Ser Arg  Arg Met Leu Ala Ser  Ile Leu Ser Thr Asn  Asn Lys Arg 
    1220                 1225                 1230             


Gly Glu  Ile His Lys Gly Asn  Gln Ile Phe Leu Ser  Gln Lys Phe 
    1235                 1240                 1245             


Val Lys  Leu Leu Tyr His Ala  Lys Arg Ile Ser Asn  Thr Ile Asn 
    1250                 1255                 1260             


Glu Asn  His Arg Lys Tyr Val  Glu Asn His Lys Lys  Glu Phe Glu 
    1265                 1270                 1275             


Glu Leu  Phe Tyr Tyr Ile Leu  Glu Phe Asn Glu Asn  Tyr Val Gly 
    1280                 1285                 1290             


Ala Lys  Lys Asn Gly Lys Leu  Leu Asn Ser Ala Phe  Gln Ser Trp 
    1295                 1300                 1305             


Gln Asn  His Ser Ile Asp Glu  Leu Cys Ser Ser Phe  Ile Gly Pro 
    1310                 1315                 1320             


Thr Gly  Ser Glu Arg Lys Gly  Leu Phe Glu Leu Thr  Ser Arg Gly 
    1325                 1330                 1335             


Ser Ala  Ala Asp Phe Glu Phe  Leu Gly Val Lys Ile  Pro Arg Tyr 
    1340                 1345                 1350             


Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Lys Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ala 
    1370                 1375                 1380             


Lys Leu  Gly Glu Gly 
    1385             


<210> 598
<211> 1128
<212> PRT
<213> Streptococcus vestibularis


<220>
<223> Streptococcus vestibularis ATCC 49124

<400> 598
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Val Glu Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn His Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Val Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Ile Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Lys Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Glu Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Lys Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Thr Thr Lys Lys Asp Ser Glu Asn Glu Tyr Ile Thr Leu Asp Asn 
                245                 250                 255     


Ile Phe Gly Ile Leu Ile Gly Lys Cys Thr Phe Tyr Pro Glu Glu Tyr 
            260                 265                 270         


Arg Ala Ala Lys Ala Ser Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn 
        275                 280                 285             


Asp Leu Asn Asn Leu Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu 
    290                 295                 300                 


Glu Gln Lys Asn Gln Ile Ile Asn Tyr Val Lys Asn Glu Lys Ala Met 
305                 310                 315                 320 


Gly Pro Ala Lys Leu Phe Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp 
                325                 330                 335     


Val Ala Asp Ile Lys Gly Tyr Arg Ile Asp Lys Ser Asp Lys Ala Glu 
            340                 345                 350         


Ile His Thr Phe Glu Ala Tyr Arg Lys Met Lys Thr Leu Glu Thr Ile 
        355                 360                 365             


Asp Phe Glu Lys Met Ser Arg Asp Gln Leu Asp Lys Leu Ala Tyr Val 
    370                 375                 380                 


Leu Thr Leu Asn Thr Glu Arg Glu Gly Ile Gln Glu Ala Leu Asp His 
385                 390                 395                 400 


Glu Phe Ala Asp Gly Asn Phe Ser Gln Glu Gln Ile Asp Glu Leu Val 
                405                 410                 415     


Gln Phe Arg Lys Ala Asn Ser Ser Ile Phe Gly Lys Gly Trp His Asn 
            420                 425                 430         


Phe Ser Val Lys Leu Met Met Glu Leu Ile Pro Glu Leu Tyr Ala Thr 
        435                 440                 445             


Ser Glu Glu Gln Met Thr Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr 
    450                 455                 460                 


Thr Ser Ser Ser Asn Lys Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr 
465                 470                 475                 480 


Glu Glu Ile Tyr Asn Pro Val Val Ala Lys Ser Val Arg Gln Ala Ile 
                485                 490                 495     


Lys Ile Val Asn Ala Ala Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile 
            500                 505                 510         


Val Ile Glu Met Ala Arg Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala 
        515                 520                 525             


Ile Gln Lys Ile Gln Lys Ala Asn Lys Asp Glu Lys Asp Ala Ala Met 
    530                 535                 540                 


Leu Lys Ala Ala Asn Gln Tyr Asn Gly Arg Ala Glu Leu Pro His Ser 
545                 550                 555                 560 


Val Phe His Gly His Lys Gln Leu Ala Thr Lys Ile Arg Leu Trp His 
                565                 570                 575     


Gln Gln Gly Glu Arg Cys Leu Tyr Thr Gly Lys Thr Ile Ser Ile His 
            580                 585                 590         


Asp Leu Ile Asn Asn Pro Asn Gln Phe Glu Ile Asp His Ile Leu Pro 
        595                 600                 605             


Leu Ser Ile Thr Phe Asp Asp Ser Leu Ala Asn Lys Val Leu Val Tyr 
    610                 615                 620                 


Ala Thr Ala Asn Gln Glu Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu 
625                 630                 635                 640 


Asp Ser Met Asp Asp Ala Trp Ser Phe Arg Glu Leu Lys Ala Phe Val 
                645                 650                 655     


Arg Glu Ser Lys Ser Leu Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr 
            660                 665                 670         


Glu Glu Asp Ile Ser Arg Phe Asp Val Arg Lys Lys Phe Ile Glu Arg 
        675                 680                 685             


Asn Leu Val Asp Thr Arg Tyr Ala Ser Arg Val Val Leu Asn Ala Leu 
    690                 695                 700                 


Gln Glu His Phe Arg Ala His Lys Thr Asp Thr Lys Val Ser Val Val 
705                 710                 715                 720 


Arg Gly Gln Phe Thr Ser Gln Leu Arg Arg His Trp Gly Ile Glu Lys 
                725                 730                 735     


Thr Arg Asp Thr Tyr His His His Ala Val Asp Ala Leu Ile Ile Ala 
            740                 745                 750         


Ala Ser Ser Gln Leu Asn Leu Trp Lys Lys Gln Lys Asn Thr Leu Val 
        755                 760                 765             


Asn Tyr Ser Glu Asn Gln Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile 
    770                 775                 780                 


Ser Asp Asp Glu Tyr Lys Glu Ser Val Phe Lys Ala Pro Tyr Gln His 
785                 790                 795                 800 


Phe Val Asp Thr Leu Lys Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe 
                805                 810                 815     


Ser Tyr Gln Val Asp Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr 
            820                 825                 830         


Ile Tyr Ala Thr Arg Gln Ala Lys Val Gly Lys Asp Lys Lys Asp Glu 
        835                 840                 845             


Thr Tyr Val Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gln Thr Gly Tyr 
    850                 855                 860                 


Asp Ala Phe Ile Lys Ile Tyr Gln Lys Asp Lys Ser Lys Phe Leu Met 
865                 870                 875                 880 


Tyr Arg His Asp Pro Gln Thr Phe Glu Lys Val Ile Glu Pro Ile Leu 
                885                 890                 895     


Glu Asn Tyr Pro Asn Lys Glu Met Asn Glu Lys Gly Lys Glu Val Pro 
            900                 905                 910         


Cys Asn Pro Phe Leu Lys Tyr Lys Glu Glu His Gly Asp Tyr Ile Arg 
        915                 920                 925             


Lys Tyr Ser Lys Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu Lys Tyr 
    930                 935                 940                 


Tyr Asp Ser Lys Leu Gly Asn His Ile Asp Ile Thr Pro Lys Asp Ser 
945                 950                 955                 960 


Asn Asn Lys Val Val Leu Gln Ser Val Ser Pro Trp Arg Ala Asp Val 
                965                 970                 975     


Tyr Phe Asn Lys Thr Thr Gly Lys Tyr Glu Ile Leu Gly Leu Lys Tyr 
            980                 985                 990         


Ala Asp Leu Gln Phe Glu Lys Gly  Thr Gly Thr Tyr Lys  Ile Ser Gln 
        995                 1000                 1005             


Glu Lys  Tyr Asn Val Ile Lys  Lys Lys Glu Gly Val  Asp Ser Asp 
    1010                 1015                 1020             


Ser Glu  Phe Lys Phe Thr Leu  Tyr Lys Asn Asp Leu  Leu Leu Ile 
    1025                 1030                 1035             


Lys Asp  Thr Glu Thr Lys Glu  Gln Gln Leu Phe Arg  Phe Leu Ser 
    1040                 1045                 1050             


Arg Thr  Lys Pro Asn Val Lys  His Tyr Val Glu Leu  Lys Pro Tyr 
    1055                 1060                 1065             


Asp Lys  Gln Lys Phe Glu Gly  Asn Glu Ser Leu Ile  Asn Val Leu 
    1070                 1075                 1080             


Gly Ala  Val Ala Lys Gly Gly  Gln Cys Gln Lys Gly  Ile Asn Lys 
    1085                 1090                 1095             


Pro Asn  Ile Ser Ile Tyr Lys  Val Arg Thr Asp Val  Leu Gly Asn 
    1100                 1105                 1110             


Gln His  Ile Ile Lys Asn Glu  Gly Asp Lys Pro Lys  Leu Asp Phe 
    1115                 1120                 1125             


<210> 599
<211> 1084
<212> PRT
<213> Subdoligranulum sp.


<220>
<223> Subdoligranulum sp. 4_3_54A2FAA

<400> 599
Met Lys Asn Thr Leu Tyr Gly Ile Gly Leu Asp Ile Gly Val Ala Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Val Gly Leu Asn Gly Thr Gly Glu Pro Val Gly 
            20                  25                  30          


Leu His Arg Leu Gly Val Arg Ile Phe Asp Lys Ala Glu Gln Pro Lys 
        35                  40                  45              


Thr Gly Glu Ser Leu Ala Ala Pro Arg Arg Met Ala Arg Gly Met Arg 
    50                  55                  60                  


Arg Arg Leu Arg Arg Lys Ala Leu Arg Arg Ala Asp Val Tyr Ala Leu 
65                  70                  75                  80  


Leu Glu Arg Ser Gly Leu Ser Thr Arg Glu Glu Leu Ala Gln Met Phe 
                85                  90                  95      


Glu Ala Gly Gly Leu Glu Asp Ile Tyr Ala Leu Arg Thr Arg Ala Leu 
            100                 105                 110         


Asp Glu Pro Val Gly Lys Ala Glu Phe Ser Arg Ile Leu Leu His Leu 
        115                 120                 125             


Ala Gln Arg Arg Gly Phe Lys Ser Asn Arg Arg Thr Ala Ser Asp Gly 
    130                 135                 140                 


Glu Asp Gly Arg Leu Leu Ala Ala Val Asn Glu Asn Arg Arg Arg Met 
145                 150                 155                 160 


Ala Gln Gly Gly Trp Arg Thr Val Gly Glu Met Leu Tyr Arg His Glu 
                165                 170                 175     


Ala Phe Ala Leu His Lys Arg Asn Lys Ala Asp Asp Tyr Leu Ser Thr 
            180                 185                 190         


Val Gly Arg Asp Met Val Ala Glu Glu Ala Ser Ile Leu Phe Glu Arg 
        195                 200                 205             


Gln Arg Ala Met Gly Cys Ser Trp Ala Ala Pro Glu Leu Gln Ala Glu 
    210                 215                 220                 


Tyr Leu Ser Ile Leu Leu Arg Gln Arg Ser Phe Asp Glu Gly Pro Gly 
225                 230                 235                 240 


Gly Asn Ser Pro Tyr Gly Gly Asn Gln Val Glu Lys Met Val Gly Arg 
                245                 250                 255     


Cys Thr Phe Glu Pro Asp Glu Pro Arg Ala Ala Lys Ala Ala Tyr Ser 
            260                 265                 270         


Phe Glu Tyr Phe Ser Leu Leu Gln Lys Leu Asn His Ile Arg Leu Ala 
        275                 280                 285             


Glu Asn Gly Glu Thr Arg Pro Leu Thr Gln Pro Gln Arg Gln Gln Leu 
    290                 295                 300                 


Leu Ser Leu Ala His Lys Thr Pro Asp Ile Ser Leu Ala Arg Ile Arg 
305                 310                 315                 320 


Lys Glu Leu Ala Leu Pro Glu Thr Val Gln Phe Asn Gly Val Arg Cys 
                325                 330                 335     


Arg Ala Asn Glu Thr Leu Glu Glu Ser Glu Lys Lys Glu Lys Phe Ala 
            340                 345                 350         


Cys Leu Pro Ala Tyr His Lys Met Arg Lys Ala Leu Asp Gly Val Val 
        355                 360                 365             


Lys Gly Arg Ile Ser Ser Leu Ser Ile Ser Gln Arg Asp Ala Ala Ala 
    370                 375                 380                 


Thr Ala Leu Ser Leu Tyr Lys Asn Glu Asp Thr Leu Arg Ala Lys Leu 
385                 390                 395                 400 


Thr Glu Ala Gly Phe Gln Ala Pro Glu Ile Asp Ala Leu Ala Gly Leu 
                405                 410                 415     


Thr Gly Phe Ser Lys Phe Gly His Leu Ser Leu Lys Ala Cys Arg Lys 
            420                 425                 430         


Leu Ile Pro His Leu Glu Gln Gly Leu Thr Tyr Asp Gln Ala Cys Thr 
        435                 440                 445             


Ala Ala Gly Tyr Asp Phe Lys Gly His Gly Ala Gly Glu Arg Ala Phe 
    450                 455                 460                 


Thr Leu Pro Ala Ala Ala Pro Glu Met Glu Gln Ile Thr Ser Pro Val 
465                 470                 475                 480 


Val Arg Arg Ala Val Ala Gln Thr Ile Lys Val Val Asn Gly Ile Ile 
                485                 490                 495     


Arg Glu Met Asp Ala Ser Pro Ala Trp Val Arg Ile Glu Leu Ala Arg 
            500                 505                 510         


Glu Leu Ser Lys Thr Phe Gly Glu Arg Gln Glu Met Asp Arg Ser Met 
        515                 520                 525             


Arg Glu Asn Ala Ala Gln Asn Glu Arg Leu Met Gln Glu Leu Arg Asp 
    530                 535                 540                 


Thr Phe His Leu Leu Ser Pro Thr Gly Gln Asp Leu Val Lys Tyr Arg 
545                 550                 555                 560 


Leu Trp Lys Glu Gln Asp Gly Val Cys Ala Tyr Ser Leu Arg Arg Leu 
                565                 570                 575     


Asp Val Glu Arg Leu Phe Glu Pro Gly Tyr Val Asp Val Asp His Ile 
            580                 585                 590         


Val Pro Tyr Ser Leu Ser Phe Asp Asp Arg Arg Ser Asn Lys Val Leu 
        595                 600                 605             


Val Leu Ser Ser Glu Asn Arg Gln Lys Gly Asn Arg Leu Pro Leu Gln 
    610                 615                 620                 


Tyr Leu Gln Gly Lys Arg Arg Glu Asp Phe Ile Val Trp Thr Asn Ser 
625                 630                 635                 640 


Ser Val His Asp Tyr Arg Lys Arg Gln Asn Leu Leu Arg Glu Lys Leu 
                645                 650                 655     


Ser Gly Asp Glu Ala Glu Gly Phe Arg Gln Arg Asn Leu Gln Asp Thr 
            660                 665                 670         


Gln His Met Ala Arg Phe Leu Tyr Asn Tyr Ile Ser Asp His Leu Ala 
        675                 680                 685             


Phe Ala Gln Ser Glu Ala Leu Gly Lys Lys Arg Val Phe Ala Val Ser 
    690                 695                 700                 


Gly Ala Val Thr Ser His Leu Arg Lys Arg Trp Gly Leu Ser Lys Val 
705                 710                 715                 720 


Arg Ala Asp Gly Asp Leu His His Ala Leu Asp Ala Ala Val Val Ala 
                725                 730                 735     


Cys Thr Thr Asp Gly Met Ile Arg Arg Ile Ser Gly Tyr Tyr Gly His 
            740                 745                 750         


Ile Glu Gly Glu Tyr Leu Gln Asp Ala Asp Gly Ala Gly Ser Gln His 
        755                 760                 765             


Ala Arg Thr Lys Glu Arg Phe Pro Ala Pro Trp Pro Arg Phe Arg Asp 
    770                 775                 780                 


Glu Leu Ile Val Arg Leu Ser Glu Gln Pro Ala Glu Pro Leu Leu Asp 
785                 790                 795                 800 


Ile Asn Pro Glu Phe Tyr Cys Glu Tyr Gly Thr Glu His Ile Arg Pro 
                805                 810                 815     


Val Phe Val Ser Arg Met Pro Arg Arg Lys Val Thr Gly Pro Gly His 
            820                 825                 830         


Lys Glu Thr Ile Lys Gly Ala Ala Ala Ala Asp Glu Gly Leu Leu Thr 
        835                 840                 845             


Val Arg Lys Ala Leu Thr Glu Leu Lys Leu Asp Lys Asp Gly Glu Ile 
    850                 855                 860                 


Lys Asp Tyr Tyr Met Pro Ser Ser Asp Thr Leu Leu Tyr Glu Ala Leu 
865                 870                 875                 880 


Lys Ala Gln Leu Arg Arg Phe Gly Gly Asp Gly Lys Lys Ala Phe Ala 
                885                 890                 895     


Glu Pro Phe Tyr Lys Pro Lys Ala Asp Gly Thr Pro Gly Pro Leu Val 
            900                 905                 910         


Arg Lys Val Lys Thr Thr Glu Lys Ala Thr Leu Thr Val Pro Val His 
        915                 920                 925             


Gly Gly Ala Ala Ser Asn Asp Thr Met Val Arg Val Asp Val Phe Leu 
    930                 935                 940                 


Val Pro Gly Asp Gly Tyr Tyr Trp Val Pro Val Tyr Thr Ala Asp Thr 
945                 950                 955                 960 


Leu Lys Pro Glu Leu Pro Asn Arg Ala Val Val Gln Gly Lys Pro Tyr 
                965                 970                 975     


Ser Glu Trp Lys Glu Met Arg Glu Glu Asp Phe Ile Phe Ser Leu Tyr 
            980                 985                 990         


Pro Asn Asp Leu Val Tyr Val Glu  His Lys Ser Gly Leu  Lys Phe Thr 
        995                 1000                 1005             


Leu Gln  Asn Ala Asp Ser Thr  Leu Glu Lys Thr Arg  Thr Gln Thr 
    1010                 1015                 1020             


Ser Ala  Phe Ala Tyr Phe Val  Ser Gly Ser Ile Ser  Thr Ala Ser 
    1025                 1030                 1035             


Ile Thr  Ile Arg Thr His Asp  Asn Ala Tyr Gly Ile  Pro Ser Leu 
    1040                 1045                 1050             


Gly Val  Lys Thr Leu Lys Thr  Phe His Lys Tyr Gln  Val Asp Val 
    1055                 1060                 1065             


Leu Gly  Asn Val Phe Pro Val  His Lys Glu Thr Arg  Gln Lys Phe 
    1070                 1075                 1080             


Arg 
    


<210> 600
<211> 1422
<212> PRT
<213> Sutterella wadsworthensis


<220>
<223> Sutterella wadsworthensis 3_1_45B

<400> 600
Met Thr Gln Ser Glu Arg Arg Phe Ser Cys Ser Ile Gly Ile Asp Met 
1               5                   10                  15      


Gly Ala Lys Tyr Thr Gly Val Phe Tyr Ala Leu Phe Asp Arg Glu Glu 
            20                  25                  30          


Leu Pro Thr Asn Leu Asn Ser Lys Ala Met Thr Leu Val Met Pro Glu 
        35                  40                  45              


Thr Gly Pro Arg Tyr Val Gln Ala Gln Arg Thr Ala Val Arg His Arg 
    50                  55                  60                  


Leu Arg Gly Gln Lys Arg Tyr Thr Leu Ala Arg Lys Leu Ala Phe Leu 
65                  70                  75                  80  


Val Val Asp Asp Met Ile Lys Lys Gln Glu Lys Arg Leu Thr Asp Glu 
                85                  90                  95      


Glu Trp Lys Arg Gly Arg Glu Ala Leu Ser Gly Leu Leu Lys Arg Arg 
            100                 105                 110         


Gly Tyr Ser Arg Pro Asn Ala Asp Gly Glu Asp Leu Thr Pro Leu Glu 
        115                 120                 125             


Asn Val Arg Ala Asp Val Phe Ala Ala His Pro Ala Phe Ser Thr Tyr 
    130                 135                 140                 


Phe Ser Glu Val Arg Ser Leu Ala Glu Gln Trp Glu Glu Phe Thr Ala 
145                 150                 155                 160 


Asn Ile Ser Asn Val Glu Lys Phe Leu Gly Asp Pro Asn Ile Pro Ala 
                165                 170                 175     


Asp Lys Glu Phe Ile Glu Phe Ala Val Ala Glu Gly Leu Ile Asp Lys 
            180                 185                 190         


Thr Glu Lys Lys Ala Tyr Gln Ser Ala Leu Ser Thr Leu Arg Ala Asn 
        195                 200                 205             


Ala Asn Val Leu Thr Gly Leu Arg Gln Met Gly His Lys Pro Arg Ser 
    210                 215                 220                 


Glu Tyr Phe Lys Ala Ile Glu Ala Asp Leu Lys Lys Asp Ser Arg Leu 
225                 230                 235                 240 


Ala Lys Ile Asn Glu Ala Phe Gly Gly Ala Glu Arg Leu Ala Arg Leu 
                245                 250                 255     


Leu Gly Asn Leu Ser Asn Leu Gln Leu Arg Ala Glu Arg Trp Tyr Phe 
            260                 265                 270         


Asn Ala Pro Asp Ile Met Lys Asp Arg Gly Trp Glu Pro Asp Arg Phe 
        275                 280                 285             


Lys Lys Thr Leu Val Arg Ala Phe Lys Phe Phe His Pro Ala Lys Asp 
    290                 295                 300                 


Gln Asn Lys Gln His Leu Glu Leu Ile Lys Gln Ile Glu Asn Ser Glu 
305                 310                 315                 320 


Asp Ile Ile Glu Thr Leu Cys Thr Leu Asp Pro Asn Arg Thr Ile Pro 
                325                 330                 335     


Pro Tyr Glu Asp Gln Asn Asn Arg Arg Pro Pro Leu Asp Gln Thr Leu 
            340                 345                 350         


Leu Leu Ser Pro Glu Lys Leu Thr Arg Gln Tyr Gly Glu Ile Trp Lys 
        355                 360                 365             


Thr Trp Ser Ala Arg Leu Thr Ser Ala Glu Pro Thr Leu Ala Pro Ala 
    370                 375                 380                 


Ala Glu Ile Leu Glu Arg Ser Thr Asp Arg Lys Ser Arg Val Ala Val 
385                 390                 395                 400 


Asn Gly His Glu Pro Leu Pro Thr Leu Ala Tyr Gln Leu Ser Tyr Ala 
                405                 410                 415     


Leu Gln Arg Ala Phe Asp Arg Ser Lys Ala Leu Asp Pro Tyr Ala Leu 
            420                 425                 430         


Arg Ala Leu Ala Ala Gly Ser Lys Ser Asn Lys Leu Thr Ser Ala Arg 
        435                 440                 445             


Thr Ala Leu Glu Asn Cys Ile Gly Gly Gln Asn Val Lys Thr Phe Leu 
    450                 455                 460                 


Asp Cys Ala Arg Arg Tyr Tyr Arg Glu Ala Asp Asp Ala Lys Val Gly 
465                 470                 475                 480 


Leu Trp Phe Asp Asn Ala Asp Gly Leu Leu Glu Arg Ser Asp Leu His 
                485                 490                 495     


Pro Pro Met Lys Lys Lys Ile Leu Pro Leu Leu Val Ala Asn Ile Leu 
            500                 505                 510         


Gln Thr Asp Glu Thr Thr Gly Gln Lys Phe Leu Asp Glu Ile Trp Arg 
        515                 520                 525             


Lys Gln Ile Lys Gly Arg Glu Thr Val Ala Ser Arg Cys Ala Arg Ile 
    530                 535                 540                 


Glu Thr Val Arg Lys Ser Phe Gly Gly Gly Phe Asn Ile Ala Tyr Asn 
545                 550                 555                 560 


Thr Ala Gln Tyr Arg Glu Val Asn Lys Leu Pro Arg Asn Ala Gln Asp 
                565                 570                 575     


Lys Glu Leu Leu Thr Ile Arg Asp Arg Val Ala Glu Thr Ala Asp Phe 
            580                 585                 590         


Ile Ala Ala Asn Leu Gly Leu Ser Asp Glu Gln Lys Arg Lys Phe Ala 
        595                 600                 605             


Asn Pro Phe Ser Leu Ala Gln Phe Tyr Thr Leu Ile Glu Thr Glu Val 
    610                 615                 620                 


Ser Gly Phe Ser Ala Thr Thr Leu Ala Val His Leu Glu Asn Ala Trp 
625                 630                 635                 640 


Arg Met Thr Ile Lys Asp Ala Val Ile Asn Gly Glu Thr Val Arg Ala 
                645                 650                 655     


Ala Gln Cys Ser Arg Leu Pro Ala Glu Thr Ala Arg Pro Phe Asp Gly 
            660                 665                 670         


Leu Val Arg Arg Leu Val Asp Arg Gln Ala Trp Glu Ile Ala Lys Arg 
        675                 680                 685             


Val Ser Thr Asp Ile Gln Ser Lys Val Asp Phe Ser Asn Gly Ile Val 
    690                 695                 700                 


Asp Val Ser Ile Phe Val Glu Glu Asn Lys Phe Glu Phe Ser Ala Ser 
705                 710                 715                 720 


Val Ala Asp Leu Lys Lys Asn Lys Arg Val Lys Asp Lys Met Leu Ser 
                725                 730                 735     


Glu Ala Glu Lys Leu Glu Thr Arg Trp Leu Ile Lys Asn Glu Arg Ile 
            740                 745                 750         


Lys Lys Ala Ser Arg Gly Thr Cys Pro Tyr Thr Gly Asp Arg Leu Ala 
        755                 760                 765             


Glu Gly Gly Glu Ile Asp His Ile Leu Pro Arg Ser Leu Ile Lys Asp 
    770                 775                 780                 


Ala Arg Gly Ile Val Phe Asn Ala Glu Pro Asn Leu Ile Tyr Ala Ser 
785                 790                 795                 800 


Ser Arg Gly Asn Gln Leu Lys Lys Asn Gln Arg Tyr Ser Leu Ser Asp 
                805                 810                 815     


Leu Lys Ala Asn Tyr Arg Asn Glu Ile Phe Lys Thr Ser Asn Ile Ala 
            820                 825                 830         


Ala Ile Thr Ala Glu Ile Glu Asp Val Val Thr Lys Leu Gln Gln Thr 
        835                 840                 845             


His Arg Leu Lys Phe Phe Asp Leu Leu Asn Glu His Glu Gln Asp Cys 
    850                 855                 860                 


Val Arg His Ala Leu Phe Leu Asp Asp Gly Ser Glu Ala Arg Asp Ala 
865                 870                 875                 880 


Val Leu Glu Leu Leu Ala Thr Gln Arg Arg Thr Arg Val Asn Gly Thr 
                885                 890                 895     


Gln Ile Trp Met Ile Lys Asn Leu Ala Asn Lys Ile Arg Glu Glu Leu 
            900                 905                 910         


Gln Asn Trp Cys Lys Thr Thr Asn Asn Arg Leu His Phe Gln Ala Ala 
        915                 920                 925             


Ala Thr Asn Val Ser Asp Ala Lys Asn Leu Arg Leu Lys Leu Ala Gln 
    930                 935                 940                 


Asn Gln Pro Asp Phe Glu Lys Pro Asp Ile Gln Pro Ile Ala Ser His 
945                 950                 955                 960 


Ser Ile Asp Ala Leu Cys Ser Phe Ala Val Gly Ser Ala Asp Ala Glu 
                965                 970                 975     


Arg Asp Gln Asn Gly Phe Asp Tyr Leu Asp Gly Lys Thr Val Leu Gly 
            980                 985                 990         


Leu Tyr Pro Gln Ser Cys Glu Val  Ile His Leu Gln Ala  Lys Pro Gln 
        995                 1000                 1005             


Glu Glu  Lys Ser His Phe Asp  Ser Val Ala Ile Phe  Lys Glu Gly 
    1010                 1015                 1020             


Ile Tyr  Ala Glu Gln Phe Leu  Pro Ile Phe Thr Leu  Asn Glu Lys 
    1025                 1030                 1035             


Ile Trp  Ile Gly Tyr Glu Thr  Leu Asn Ala Lys Gly  Glu Arg Cys 
    1040                 1045                 1050             


Gly Ala  Ile Glu Val Ser Gly  Lys Gln Pro Lys Glu  Leu Leu Glu 
    1055                 1060                 1065             


Met Leu  Ala Pro Phe Phe Asn  Lys Pro Val Gly Asp  Leu Ser Ala 
    1070                 1075                 1080             


His Ala  Thr Tyr Arg Ile Leu  Lys Lys Pro Ala Tyr  Glu Phe Leu 
    1085                 1090                 1095             


Ala Lys  Ala Ala Leu Gln Pro  Leu Ser Ala Glu Glu  Lys Arg Leu 
    1100                 1105                 1110             


Ala Ala  Leu Leu Asp Ala Leu  Arg Tyr Cys Thr Ser  Arg Lys Ser 
    1115                 1120                 1125             


Leu Met  Ser Leu Phe Met Ala  Ala Asn Gly Lys Ser  Leu Lys Lys 
    1130                 1135                 1140             


Arg Glu  Asp Val Leu Lys Pro  Lys Leu Phe Gln Leu  Lys Val Glu 
    1145                 1150                 1155             


Leu Lys  Gly Glu Lys Ser Phe  Lys Leu Asn Gly Ser  Leu Thr Leu 
    1160                 1165                 1170             


Pro Val  Lys Gln Asp Trp Leu  Arg Ile Cys Asp Ser  Pro Glu Leu 
    1175                 1180                 1185             


Ala Asp  Ala Phe Gly Lys Pro  Cys Ser Ala Asp Glu  Leu Thr Ser 
    1190                 1195                 1200             


Lys Leu  Ala Arg Ile Trp Lys  Arg Pro Val Met Arg  Asp Leu Ala 
    1205                 1210                 1215             


His Ala  Pro Val Arg Arg Glu  Phe Ser Leu Pro Ala  Ile Asp Asn 
    1220                 1225                 1230             


Pro Ser  Gly Gly Phe Arg Ile  Arg Arg Thr Asn Leu  Phe Gly Asn 
    1235                 1240                 1245             


Glu Leu  Tyr Gln Val His Ala  Ile Asn Ala Lys Lys  Tyr Arg Gly 
    1250                 1255                 1260             


Phe Ala  Ser Ala Gly Ser Asn  Val Asp Trp Ser Lys  Gly Ile Leu 
    1265                 1270                 1275             


Phe Asn  Glu Leu Gln His Glu  Asn Leu Thr Glu Cys  Gly Gly Arg 
    1280                 1285                 1290             


Phe Ile  Thr Ser Ala Asp Val  Thr Pro Met Ser Glu  Trp Arg Lys 
    1295                 1300                 1305             


Val Val  Ala Glu Asp Asn Leu  Ser Ile Trp Ile Ala  Pro Gly Thr 
    1310                 1315                 1320             


Glu Gly  Arg Arg Tyr Val Arg  Val Glu Thr Thr Phe  Ile Gln Ala 
    1325                 1330                 1335             


Ser His  Trp Phe Glu Gln Ser  Val Glu Asn Trp Ala  Ile Thr Ser 
    1340                 1345                 1350             


Pro Leu  Ser Leu Pro Ala Ser  Phe Lys Val Asp Lys  Pro Ala Glu 
    1355                 1360                 1365             


Phe Gln  Lys Ala Val Gly Thr  Glu Leu Ser Glu Leu  Leu Gly Gln 
    1370                 1375                 1380             


Pro Arg  Ser Glu Ile Phe Ile  Glu Asn Val Gly Asn  Ala Lys His 
    1385                 1390                 1395             


Ile Arg  Phe Trp Tyr Ile Val  Val Ser Ser Asn Lys  Lys Met Asn 
    1400                 1405                 1410             


Glu Ser  Tyr Asn Asn Val Ser  Lys Ser 
    1415                 1420         


<210> 601
<211> 1049
<212> PRT
<213> Tistrella mobilis

<400> 601
Met Ile Asn Glu Arg Leu Thr Phe Gly Ile Asp Leu Gly Ile Gly Ser 
1               5                   10                  15      


Cys Gly Trp Ala Val Leu Arg His Ala Asp Ala Ala Gly Glu Pro Gly 
            20                  25                  30          


Val Ile Glu Gly Leu Gly Ser Trp Cys Phe Asp Val Pro Glu Thr Ser 
        35                  40                  45              


Lys Glu Arg Ile Pro Thr Asn Gln Val Arg Arg Ser Asn Arg Leu Leu 
    50                  55                  60                  


Arg Arg Val Ile Arg Arg Arg Arg Asn Arg Met Ala Glu Ile Arg Arg 
65                  70                  75                  80  


Leu Phe His Ala Gln Gly Leu Leu Pro Ser Ala Asp Glu Asp Ala Leu 
                85                  90                  95      


Lys Arg Pro Arg Leu Asp Pro Trp Glu Leu Arg Ala Arg Gly Leu Asp 
            100                 105                 110         


Gln Cys Leu Ser Ala Glu Glu Phe Ala Val Ala Leu Gly His Ile Ala 
        115                 120                 125             


Arg His Arg Gly Phe Arg Ser Ser Ala Lys Arg Lys Ala Ala Asn Thr 
    130                 135                 140                 


Ser Gly Glu Asp Ser Lys Met Leu Ser Ala Leu Leu Val Thr Arg Glu 
145                 150                 155                 160 


Arg Thr Ala Arg Tyr Arg Thr Val Gly Glu Met Phe Ala Arg Asp Pro 
                165                 170                 175     


Glu Tyr Ser Ala Arg Arg Arg Asn Arg Asp Gly Ile Phe Asp Arg Thr 
            180                 185                 190         


Val Ala Arg Asp Asp Leu Ile His Glu Val Gly Lys Leu Phe Glu Ala 
        195                 200                 205             


Gln Arg Ala Arg Gly Ser Ala Phe Ala Ser Pro Asp Leu Glu Ala Asp 
    210                 215                 220                 


Phe Asn Ala Ile Ala Phe Arg Gln Ala Glu Met Gln Asp Ser Glu Arg 
225                 230                 235                 240 


Leu Val Gly Asn Cys Pro Phe Glu Arg Asp Glu Lys Arg Ala Ala Arg 
                245                 250                 255     


Trp Ala Pro Ser Phe Glu Arg Phe Arg Leu Leu Thr Arg Leu Ile Asn 
            260                 265                 270         


Leu Arg Ile Ala Thr Ala Glu Gly Glu Arg Arg Phe Thr Pro Glu Asp 
        275                 280                 285             


Leu Ala Arg Val Ser Ala Glu Leu Gly Ala Thr Ala Lys Leu Pro Val 
    290                 295                 300                 


Ser Arg Val Arg Ala Leu Ile Gly Leu Leu Pro Asp Glu Arg Phe Thr 
305                 310                 315                 320 


Thr Ile Arg Val Glu Asp Glu Asp Arg Asp Ile Val Ala Arg Thr Gly 
                325                 330                 335     


Glu Ala Ala Pro Gly Thr Trp Arg Leu Arg Lys Thr Leu Gly Glu Ala 
            340                 345                 350         


Leu Trp Ala Glu Met Gln Ala Arg Pro Asp Gln Leu Asp Ala Ile Ala 
        355                 360                 365             


His Val Leu Ser Phe Phe Glu Ala Thr Ala Lys Ile Arg Ser Glu Leu 
    370                 375                 380                 


Asp Arg Leu Gly Leu Pro Ala Ala Val Ile Glu Ala Leu Asp Arg Gly 
385                 390                 395                 400 


Leu Glu Asp Gly Ala Phe Ala Lys Phe Lys Gly Ala Gly His Ile Ser 
                405                 410                 415     


Ala Lys Ala Cys Arg Asn Leu Leu Pro His Leu Gln Gln Gly His Arg 
            420                 425                 430         


Tyr Asp Gln Ala Cys Arg Leu Ala Gly Tyr Asp His Ala Ala Ser Thr 
        435                 440                 445             


Leu Ser His Thr Ala Gln Val Val Ser Lys Ala Gly Phe Asn Ala Leu 
    450                 455                 460                 


Val Thr Glu Leu Gly Glu Ser Ile Ala Asn Pro Ile Ala Arg Lys Ala 
465                 470                 475                 480 


Leu Thr Glu Gly Leu Lys Gln Ile Arg Ala Met Cys Ala Arg Trp Gly 
                485                 490                 495     


Leu Pro Gly Ala Ile His Ile Glu Leu Ala Arg Glu Val Gly Asn Ser 
            500                 505                 510         


Ile Glu Lys Arg Arg Glu Leu Glu Ser Gln Arg Glu Thr Thr Thr Lys 
        515                 520                 525             


Arg Arg Gln Thr Glu Arg Asp Glu Ile Arg Gly Leu Leu Ala Leu Glu 
    530                 535                 540                 


Asp Val Asp Asp Asp Thr Leu Leu Arg Tyr Arg Leu Trp Lys Glu Gln 
545                 550                 555                 560 


Gly Gly Lys Cys Leu Tyr Thr Gly Lys Asp Ile His Val Arg Gln Leu 
                565                 570                 575     


Ile Ala Thr Asp Asn Ser Val Gln Val Asp His Ile Leu Pro Trp Ser 
            580                 585                 590         


Arg Phe Gly Asp Asp Ser Phe Asn Asn Lys Thr Leu Cys Leu Ala Ser 
        595                 600                 605             


Ala Asn Gln Arg Lys Arg Gly Gln Thr Pro Trp Glu Trp Phe Ser Leu 
    610                 615                 620                 


Thr Gly Thr Pro Glu Ala Trp Glu Val Phe Ala Ser Arg Val Glu Thr 
625                 630                 635                 640 


Ser Lys Asp Leu Arg Gly Phe Lys Lys Arg Asn Leu Leu Leu Lys Asn 
                645                 650                 655     


Ala Asp Glu Val Ala Gln Arg Phe Arg Ser Arg Asn Leu Asn Asp Thr 
            660                 665                 670         


Arg Tyr Ala Ala Arg Leu Leu Ala Glu Ala Ala Lys Leu Phe Tyr Pro 
        675                 680                 685             


Ala Gly Asp Arg Gln Glu Lys Asp Gly Arg Arg Arg Val Leu Thr Arg 
    690                 695                 700                 


Pro Gly Pro Leu Thr Ala Ala Leu Arg His Ala Trp Gly Leu Glu Ser 
705                 710                 715                 720 


Leu Lys Lys Ala Asp Gly Lys Arg Val Ser Asp Asp Arg His His Ala 
                725                 730                 735     


Leu Asp Ala Leu Ala Val Ala Ala Ile Ser Glu Arg Glu Val Gln Arg 
            740                 745                 750         


Leu Thr Arg Ser Phe Gln Glu Trp Glu Gln Gln Gly Leu Ala Arg Pro 
        755                 760                 765             


Leu Arg His Val Ala Pro Pro Trp Pro Gly Phe Arg Gly Asp Val Leu 
    770                 775                 780                 


Ala Ala Tyr Ala Gln Ala Phe Val Ala Arg Pro Glu Arg Arg Arg Ala 
785                 790                 795                 800 


Arg Gly Lys Gly His Asp Ala Ser Ile Arg Gln Val Val Gly Glu Gly 
                805                 810                 815     


Pro Glu Ala Gln Val Phe Glu Arg Arg Gly Leu Ala Asp Leu Lys Glu 
            820                 825                 830         


Ala Asp Leu Asp Arg Val Lys Asp Pro Glu Arg Asn Gln Ala Ile Ile 
        835                 840                 845             


Glu Ala Val Arg Ala Trp Ile Leu Ala Gly Arg Pro Ala Asp Ala Pro 
    850                 855                 860                 


Pro Arg Ser Pro Arg Gly Asp Val Ile Val Lys Leu Arg Thr Ala Pro 
865                 870                 875                 880 


Ala Lys Lys Ile Lys Pro Ala Val Pro Val Arg Gly Gly Thr Ala Asp 
                885                 890                 895     


Arg Gly Asp Met Val Arg Ile Asp Val Phe Thr Arg Pro Asn Arg Lys 
            900                 905                 910         


Gly Arg Asp Glu Trp Tyr Leu Val Pro Ile Tyr Pro His Gln Val Met 
        915                 920                 925             


Asn Arg Lys Ala Trp Pro His Pro Pro Met Arg Ser Val Val Ala Tyr 
    930                 935                 940                 


Lys Asp Glu Ala Gly Trp Thr Glu Ile Gly Ala Glu His Ser Phe Arg 
945                 950                 955                 960 


Phe Ser Leu Tyr Pro Arg Ser Tyr Val Gln Leu Val Lys Ser Asn Gly 
                965                 970                 975     


Asp Val Ile Glu Gly Tyr Leu Val Ser Met Asp Arg Ser Thr Gly Ala 
            980                 985                 990         


Phe Arg Val Phe Val His Asn Asn  Pro Ala Glu Met Ala  Lys Gly Ile 
        995                 1000                 1005             


Gly Ala  Lys Thr Leu Leu Asn  Leu Arg Lys Phe Asn  Val Asp Arg 
    1010                 1015                 1020             


Phe Gly  Val Arg Thr Glu Val  Lys Ser Glu Val Arg  Thr Trp His 
    1025                 1030                 1035             


Gly Glu  Val Cys Thr Ser Pro  Val Pro Pro Asp 
    1040                 1045                 


<210> 602
<211> 1395
<212> PRT
<213> Treponema denticola


<220>
<223> Treponema denticola AL-2

<400> 602
Met Lys Lys Glu Ile Lys Asp Tyr Phe Leu Gly Leu Asp Val Gly Thr 
1               5                   10                  15      


Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 
            20                  25                  30          


Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 
        35                  40                  45              


Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 
    50                  55                  60                  


Arg Arg Lys Lys Arg Ile Lys Leu Leu Gln Glu Leu Phe Ser Gln Glu 
65                  70                  75                  80  


Ile Ala Lys Ile Asp Glu Gly Phe Phe Gln Arg Met Lys Glu Ser Pro 
                85                  90                  95      


Phe Tyr Ala Glu Asp Lys Thr Ile Leu Gln Glu Asn Ala Leu Phe Asn 
            100                 105                 110         


Asp Lys Asp Phe Thr Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 
        115                 120                 125             


Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 
    130                 135                 140                 


Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 
145                 150                 155                 160 


Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gln Phe Asp Thr Ser 
                165                 170                 175     


Ile Gln Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 
            180                 185                 190         


Asp Ala Asp Ser Gln Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 
        195                 200                 205             


Lys Asn Ser Glu Lys Gln Ser Arg Leu Asn Lys Ile Leu Gly Leu Lys 
    210                 215                 220                 


Pro Ser Asp Lys Gln Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 
225                 230                 235                 240 


Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 
                245                 250                 255     


Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 
            260                 265                 270         


Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 
        275                 280                 285             


Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 
    290                 295                 300                 


Glu Gln Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 
305                 310                 315                 320 


Thr Asp Leu Thr Lys Leu Lys Ala Val Ile Lys Lys His Phe Pro Asn 
                325                 330                 335     


Asn Tyr Lys Lys Val Phe Gly Tyr Asn Gln Asp Asn Glu Ser Lys Asn 
            340                 345                 350         


Asn Tyr Ser Gly Tyr Val Gly Val Cys Lys Thr Lys Asn Lys Lys Leu 
        355                 360                 365             


Val Ile Asn Asn Ser Val Asn Gln Glu Asp Phe Tyr Lys Phe Leu Lys 
    370                 375                 380                 


Pro Ile Leu Ser Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 
385                 390                 395                 400 


Ala Glu Ile Glu Thr Gly Asn Phe Leu Pro Lys Gln Ile Ser Lys Ser 
                405                 410                 415     


Asn Ala Glu Ile Pro Tyr Gln Leu Arg Lys Met Glu Leu Glu Lys Ile 
            420                 425                 430         


Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gln Lys Asp Glu 
        435                 440                 445             


Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 
    450                 455                 460                 


Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Ser Phe 
465                 470                 475                 480 


Pro Asp Arg Cys Trp Val Val Lys Lys Glu Lys Ser Pro Ser Gly Lys 
                485                 490                 495     


Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Glu Lys Thr Ala 
            500                 505                 510         


Glu Glu Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Ile Gly 
        515                 520                 525             


Glu Ser Val Leu Pro Lys Asn Ser Leu Leu Tyr Ser Glu Tyr Thr Val 
    530                 535                 540                 


Leu Asn Glu Ile Asn Asn Leu Gln Ile Ile Ile Asp Gly Lys Asn Ile 
545                 550                 555                 560 


Cys Asp Thr Lys Leu Lys Gln Lys Ile Tyr Glu Asp Leu Phe Lys Lys 
                565                 570                 575     


Tyr Lys Lys Ile Thr Gln Lys Gln Ile Ser Thr Phe Ile Lys His Glu 
            580                 585                 590         


Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 
        595                 600                 605             


Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 
    610                 615                 620                 


Gly Lys Gln Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 
625                 630                 635                 640 


Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 
                645                 650                 655     


Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gln 
            660                 665                 670         


Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 
        675                 680                 685             


Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 
    690                 695                 700                 


Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gln Asn Asn Leu Met 
705                 710                 715                 720 


Glu Leu Leu Ser Ser Glu Phe Lys Phe Thr Glu Asn Ile Lys Lys Ile 
                725                 730                 735     


Asn Ser Gly Phe Glu Asp Ala Glu Lys Gln Phe Ser Tyr Asp Gly Leu 
            740                 745                 750         


Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gln 
        755                 760                 765             


Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gln Ala Pro Pro 
    770                 775                 780                 


Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Glu Pro Ala 
785                 790                 795                 800 


Arg Thr Lys Thr Arg Leu Lys Ile Leu Gln Asp Leu Tyr Ser Ser Cys 
                805                 810                 815     


Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Gln Tyr Leu Ser Gly 
            820                 825                 830         


Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser Asp Lys Leu Tyr 
        835                 840                 845             


Leu Tyr Tyr Thr Gln Leu Gly Lys Cys Met Tyr Cys Gly Lys Pro Ile 
    850                 855                 860                 


Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp Ile Asp His Ile 
865                 870                 875                 880 


Tyr Pro Gln Ser Lys Ile Lys Asp Asp Ser Ile Ser Asn Arg Val Leu 
                885                 890                 895     


Val Cys Ser Ser Cys Asn Lys Asn Lys Glu Asp Lys Tyr Pro Leu Lys 
            900                 905                 910         


Ser Glu Ile Gln Ser Lys Gln Arg Gly Phe Trp Asn Phe Leu Gln Arg 
        915                 920                 925             


Asn Asn Phe Ile Ser Leu Glu Lys Leu Asn Arg Leu Thr Arg Thr Thr 
    930                 935                 940                 


Pro Ile Ser Asp Asp Glu Thr Ala Lys Phe Ile Ala Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ala Thr Lys Val Ala Ala Lys Val Leu Glu Lys Met 
                965                 970                 975     


Phe Pro Glu Thr Lys Ile Val Tyr Ser Lys Ala Glu Thr Val Ser Met 
            980                 985                 990         


Phe Arg Asn Lys Phe Asp Ile Ile  Lys Cys Arg Glu Ile  Asn Asp Phe 
        995                 1000                 1005             


His His  Ala His Asp Ala Tyr  Leu Asn Ile Val Val  Gly Asn Val 
    1010                 1015                 1020             


Tyr Asn  Thr Lys Phe Thr Asn  Asn Pro Trp Asn Phe  Ile Lys Glu 
    1025                 1030                 1035             


Lys Arg  Asp Asn Pro Lys Ile  Ala Asp Thr Tyr Asn  Tyr Tyr Lys 
    1040                 1045                 1050             


Val Phe  Asp Tyr Asp Val Lys  Arg Asn Asn Ile Thr  Ala Trp Glu 
    1055                 1060                 1065             


Lys Gly  Lys Thr Ile Ile Thr  Val Lys Asp Met Leu  Lys Arg Asn 
    1070                 1075                 1080             


Thr Pro  Ile Tyr Thr Arg Gln  Ala Ala Cys Lys Lys  Gly Gly Leu 
    1085                 1090                 1095             


Phe Asp  Gln Thr Ile Met Lys  Lys Gly Leu Gly Gln  His Pro Leu 
    1100                 1105                 1110             


Lys Lys  Glu Gly Pro Phe Ser  Asn Ile Ser Lys Tyr  Gly Gly Tyr 
    1115                 1120                 1125             


Asn Lys  Val Ser Ala Ala Tyr  Tyr Thr Leu Ile Glu  Tyr Glu Glu 
    1130                 1135                 1140             


Lys Gly  Asn Lys Ile Arg Ser  Leu Glu Thr Ile Pro  Leu Tyr Leu 
    1145                 1150                 1155             


Val Lys  Asp Ile Gln Lys Asp  Gln Asp Val Leu Lys  Ser Tyr Leu 
    1160                 1165                 1170             


Thr Asp  Leu Leu Gly Lys Lys  Glu Phe Lys Ile Leu  Val Pro Lys 
    1175                 1180                 1185             


Ile Lys  Ile Asn Ser Leu Leu  Lys Ile Asn Gly Phe  Pro Cys His 
    1190                 1195                 1200             


Ile Thr  Gly Lys Thr Asn Asp  Ser Phe Leu Leu Arg  Pro Ala Val 
    1205                 1210                 1215             


Gln Phe  Cys Cys Ser Asn Asp  Glu Val Leu Tyr Phe  Lys Lys Ile 
    1220                 1225                 1230             


Ile Arg  Phe Ser Glu Ile Arg  Ser Gln Arg Glu Lys  Ile Gly Lys 
    1235                 1240                 1245             


Thr Ile  Ser Pro Tyr Glu Asp  Leu Ser Phe Arg Ser  Tyr Ile Lys 
    1250                 1255                 1260             


Glu Asn  Leu Cys Lys Lys Thr  Lys Asn Asp Glu Ile  Gly Glu Lys 
    1265                 1270                 1275             


Glu Phe  Tyr Asp Leu Leu Gln  Lys Lys Asn Leu Glu  Ile Tyr Asp 
    1280                 1285                 1290             


Met Leu  Leu Thr Lys His Lys  Asp Thr Ile Tyr Lys  Lys Arg Pro 
    1295                 1300                 1305             


Asn Ser  Ala Thr Ile Asp Ile  Leu Val Lys Gly Lys  Glu Lys Phe 
    1310                 1315                 1320             


Lys Ser  Leu Ile Ile Glu Asn  Gln Phe Glu Val Ile  Leu Glu Ile 
    1325                 1330                 1335             


Leu Lys  Leu Phe Ser Ala Thr  Arg Asn Val Ser Glu  Leu Gln His 
    1340                 1345                 1350             


Ile Gly  Gly Ser Lys Tyr Ser  Gly Val Ala Lys Ile  Gly Asn Lys 
    1355                 1360                 1365             


Ile Ser  Ser Leu Asp Asn Cys  Ile Leu Ile Tyr Gln  Ser Ile Thr 
    1370                 1375                 1380             


Gly Ile  Phe Glu Lys Arg Ile  Asp Leu Leu Lys Val  
    1385                 1390                 1395 


<210> 603
<211> 1395
<212> PRT
<213> Treponema denticola


<220>
<223> Treponema denticola ASLM

<400> 603
Met Lys Lys Glu Ile Lys Asp Tyr Phe Leu Gly Leu Asp Val Gly Thr 
1               5                   10                  15      


Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 
            20                  25                  30          


Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 
        35                  40                  45              


Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 
    50                  55                  60                  


Arg Arg Lys Lys Arg Ile Lys Leu Leu Gln Glu Leu Phe Ser Gln Glu 
65                  70                  75                  80  


Ile Ala Lys Ile Asp Glu Gly Phe Phe Gln Arg Met Lys Glu Ser Pro 
                85                  90                  95      


Leu Tyr Ala Glu Asp Lys Thr Ile Leu Gln Glu Asn Thr Leu Phe Asn 
            100                 105                 110         


Asp Lys Asp Phe Thr Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 
        115                 120                 125             


Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 
    130                 135                 140                 


Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 
145                 150                 155                 160 


Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gln Phe Asp Thr Ser 
                165                 170                 175     


Ile Gln Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 
            180                 185                 190         


Asp Ala Asp Ser Gln Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 
        195                 200                 205             


Lys Asn Ser Glu Lys Gln Ser Arg Leu Asn Lys Met Leu Gly Leu Lys 
    210                 215                 220                 


Pro Ser Asp Lys Gln Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 
225                 230                 235                 240 


Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 
                245                 250                 255     


Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 
            260                 265                 270         


Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 
        275                 280                 285             


Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 
    290                 295                 300                 


Glu Gln Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 
305                 310                 315                 320 


Thr Asp Leu Thr Lys Leu Lys Asn Val Ile Lys Lys His Phe Pro Lys 
                325                 330                 335     


Asp Tyr Lys Lys Val Phe Gly Tyr Asn Lys Asn Glu Lys Asn Asn Asn 
            340                 345                 350         


Asn Tyr Ser Gly Tyr Val Gly Val Cys Lys Thr Lys Ser Lys Lys Leu 
        355                 360                 365             


Ile Ile Asn Asn Ser Val Asn Gln Glu Asp Phe Tyr Lys Phe Leu Lys 
    370                 375                 380                 


Thr Ile Leu Ser Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 
385                 390                 395                 400 


Thr Glu Ile Glu Thr Gly Thr Phe Leu Pro Lys Gln Ile Ser Lys Ser 
                405                 410                 415     


Asn Ala Glu Ile Pro Tyr Gln Leu Arg Lys Met Glu Leu Glu Lys Ile 
            420                 425                 430         


Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gln Lys Asp Glu 
        435                 440                 445             


Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 
    450                 455                 460                 


Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Ser Phe 
465                 470                 475                 480 


Pro Asp Arg Cys Trp Val Val Lys Lys Glu Lys Ser Pro Ser Gly Lys 
                485                 490                 495     


Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Glu Lys Thr Ala 
            500                 505                 510         


Glu Glu Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Ile Gly 
        515                 520                 525             


Glu Ser Val Leu Pro Lys Asn Ser Leu Leu Tyr Ser Glu Tyr Thr Val 
    530                 535                 540                 


Leu Asn Glu Ile Asn Asn Leu Gln Ile Ile Ile Asp Gly Lys Asn Ile 
545                 550                 555                 560 


Cys Asp Thr Lys Leu Lys Gln Lys Ile Tyr Glu Glu Leu Phe Lys Lys 
                565                 570                 575     


Tyr Lys Lys Ile Thr Gln Lys Gln Ile Ser Thr Phe Ile Lys His Glu 
            580                 585                 590         


Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 
        595                 600                 605             


Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 
    610                 615                 620                 


Gly Lys Gln Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 
625                 630                 635                 640 


Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 
                645                 650                 655     


Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gln 
            660                 665                 670         


Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 
        675                 680                 685             


Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 
    690                 695                 700                 


Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gln Asn Asn Leu Met 
705                 710                 715                 720 


Glu Leu Leu Ser Ser Glu Phe Lys Phe Thr Glu Asn Ile Lys Lys Ile 
                725                 730                 735     


Asn Ser Gly Phe Glu Asp Val Glu Lys Gln Phe Ser Tyr Asp Gly Leu 
            740                 745                 750         


Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gln 
        755                 760                 765             


Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gln Ala Pro Pro 
    770                 775                 780                 


Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Asp Pro Val 
785                 790                 795                 800 


Arg Thr Lys Thr Arg Leu Lys Ile Leu Gln Asp Leu Tyr Asn Asn Cys 
                805                 810                 815     


Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Lys Asp Leu Ser Gly 
            820                 825                 830         


Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser Asp Lys Leu Tyr 
        835                 840                 845             


Leu Tyr Tyr Thr Gln Leu Gly Lys Cys Met Tyr Cys Gly Lys Pro Ile 
    850                 855                 860                 


Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp Ile Asp His Ile 
865                 870                 875                 880 


Tyr Pro Gln Ser Lys Ile Lys Asp Asp Ser Ile Ser Asn Arg Val Leu 
                885                 890                 895     


Val Cys Ser Ser Cys Asn Lys Asn Lys Glu Asp Lys Tyr Pro Leu Lys 
            900                 905                 910         


Ala Glu Ile Gln Ser Lys Gln Arg Gly Phe Trp Asn Phe Leu Gln Arg 
        915                 920                 925             


Asn Asn Phe Ile Ser Leu Glu Lys Phe Asn Arg Leu Thr Arg Ala Thr 
    930                 935                 940                 


Pro Ile Ser Asp Asp Glu Thr Ala Lys Phe Ile Ala Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ala Thr Lys Val Ala Ala Arg Val Leu Glu Lys Met 
                965                 970                 975     


Phe Pro Glu Thr Lys Ile Val Tyr Ser Lys Ala Glu Thr Val Ser Met 
            980                 985                 990         


Phe Arg Asn Lys Phe Asp Ile Val  Lys Cys Arg Glu Ile  Asn Asp Phe 
        995                 1000                 1005             


His His  Ala His Asp Ala Tyr  Leu Asn Ile Val Val  Gly Asn Val 
    1010                 1015                 1020             


Tyr Asn  Thr Lys Phe Thr Asn  Asn Leu Trp Asn Phe  Ile Lys Glu 
    1025                 1030                 1035             


Lys Arg  Asp Asn Pro Lys Ile  Ala Asp Thr Tyr Asn  Tyr Tyr Lys 
    1040                 1045                 1050             


Val Phe  Asp Tyr Asp Val Lys  Arg Asn Asn Ile Thr  Ala Trp Glu 
    1055                 1060                 1065             


Lys Gly  Lys Thr Ile Ile Thr  Val Lys Asp Met Leu  Lys Arg Asn 
    1070                 1075                 1080             


Thr Pro  Ile Tyr Thr Arg Gln  Ala Ala Cys Lys Lys  Gly Gly Leu 
    1085                 1090                 1095             


Phe Asp  Gln Thr Ile Met Lys  Lys Gly Leu Gly Gln  His Pro Leu 
    1100                 1105                 1110             


Lys Lys  Glu Gly Pro Phe Ser  Asn Ile Ser Lys Tyr  Gly Gly Tyr 
    1115                 1120                 1125             


Asn Lys  Val Ser Ala Ala Tyr  Tyr Thr Leu Ile Glu  Tyr Glu Glu 
    1130                 1135                 1140             


Lys Gly  Asn Lys Ile Arg Ser  Leu Glu Thr Ile Pro  Leu Tyr Leu 
    1145                 1150                 1155             


Val Lys  Asp Ile Gln Lys Asp  Gln Asp Val Leu Lys  Ser Tyr Leu 
    1160                 1165                 1170             


Thr Asp  Leu Leu Gly Lys Lys  Glu Phe Lys Ile Leu  Val Pro Lys 
    1175                 1180                 1185             


Ile Lys  Ile Asn Ser Leu Leu  Lys Ile Asn Gly Phe  Pro Cys His 
    1190                 1195                 1200             


Ile Thr  Gly Lys Thr Asn Asp  Ser Phe Leu Leu Arg  Pro Ala Val 
    1205                 1210                 1215             


Gln Phe  Cys Cys Ser Asn Asp  Glu Val Leu Tyr Phe  Lys Lys Ile 
    1220                 1225                 1230             


Ile Arg  Phe Ser Glu Ile Arg  Ser Gln Arg Glu Lys  Ile Gly Lys 
    1235                 1240                 1245             


Thr Ile  Ser Pro Tyr Glu Asp  Leu Ser Phe Arg Ser  Tyr Ile Lys 
    1250                 1255                 1260             


Glu Asn  Leu Cys Lys Lys Thr  Lys Asn Asp Glu Ile  Gly Glu Lys 
    1265                 1270                 1275             


Glu Phe  Tyr Asp Leu Leu Gln  Lys Lys Asn Leu Glu  Ile Tyr Asp 
    1280                 1285                 1290             


Met Leu  Leu Thr Lys His Lys  Asp Thr Ile Tyr Lys  Lys Arg Pro 
    1295                 1300                 1305             


Asn Ser  Ala Thr Ile Asp Ile  Leu Val Lys Gly Lys  Glu Lys Phe 
    1310                 1315                 1320             


Lys Ser  Leu Ile Ile Glu Asn  Gln Phe Glu Val Ile  Leu Glu Ile 
    1325                 1330                 1335             


Leu Lys  Leu Phe Ser Ala Thr  Arg Asn Val Ser Asp  Leu Gln His 
    1340                 1345                 1350             


Ile Gly  Gly Ser Lys Tyr Ser  Gly Val Ala Lys Ile  Gly Asn Lys 
    1355                 1360                 1365             


Ile Ser  Ser Leu Asp Asn Cys  Ile Leu Ile Tyr Gln  Ser Ile Thr 
    1370                 1375                 1380             


Gly Ile  Phe Glu Lys Arg Ile  Asp Leu Leu Lys Val  
    1385                 1390                 1395 


<210> 604
<211> 1395
<212> PRT
<213> Treponema denticola


<220>
<223> Treponema denticola ATCC 35405

<400> 604
Met Lys Lys Glu Ile Lys Asp Tyr Phe Leu Gly Leu Asp Val Gly Thr 
1               5                   10                  15      


Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 
            20                  25                  30          


Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 
        35                  40                  45              


Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 
    50                  55                  60                  


Arg Arg Lys Lys Arg Ile Lys Leu Leu Gln Glu Leu Phe Ser Gln Glu 
65                  70                  75                  80  


Ile Ala Lys Thr Asp Glu Gly Phe Phe Gln Arg Met Lys Glu Ser Pro 
                85                  90                  95      


Phe Tyr Ala Glu Asp Lys Thr Ile Leu Gln Glu Asn Thr Leu Phe Asn 
            100                 105                 110         


Asp Lys Asp Phe Ala Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 
        115                 120                 125             


Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 
    130                 135                 140                 


Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 
145                 150                 155                 160 


Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gln Phe Asp Thr Ser 
                165                 170                 175     


Ile Gln Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 
            180                 185                 190         


Asp Ala Asp Ser Gln Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 
        195                 200                 205             


Lys Asn Ser Glu Lys Gln Ser Arg Leu Asn Lys Ile Leu Gly Leu Lys 
    210                 215                 220                 


Pro Ser Asp Lys Gln Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 
225                 230                 235                 240 


Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 
                245                 250                 255     


Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 
            260                 265                 270         


Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 
        275                 280                 285             


Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 
    290                 295                 300                 


Glu Gln Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 
305                 310                 315                 320 


Thr Asp Leu Thr Lys Leu Lys Asn Val Ile Lys Lys His Phe Pro Lys 
                325                 330                 335     


Asp Tyr Lys Lys Val Phe Gly Tyr Asn Lys Asn Glu Lys Asn Asn Asn 
            340                 345                 350         


Asn Tyr Ser Gly Tyr Val Gly Val Cys Lys Thr Lys Ser Lys Lys Leu 
        355                 360                 365             


Ile Ile Asn Asn Ser Val Asn Gln Glu Asp Phe Tyr Lys Phe Leu Lys 
    370                 375                 380                 


Thr Ile Leu Ser Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 
385                 390                 395                 400 


Thr Glu Ile Glu Thr Gly Thr Phe Leu Pro Lys Gln Ile Ser Lys Ser 
                405                 410                 415     


Asn Ala Glu Ile Pro Tyr Gln Leu Arg Lys Met Glu Leu Glu Lys Ile 
            420                 425                 430         


Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gln Lys Asp Glu 
        435                 440                 445             


Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 
    450                 455                 460                 


Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Phe Phe 
465                 470                 475                 480 


Pro Asp Arg Cys Trp Val Val Lys Lys Glu Lys Ser Pro Ser Gly Lys 
                485                 490                 495     


Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Glu Lys Thr Ala 
            500                 505                 510         


Glu Ala Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Val Gly 
        515                 520                 525             


Glu Ser Val Leu Pro Lys Ser Ser Leu Leu Tyr Ser Glu Tyr Thr Val 
    530                 535                 540                 


Leu Asn Glu Ile Asn Asn Leu Gln Ile Ile Ile Asp Gly Lys Asn Ile 
545                 550                 555                 560 


Cys Asp Ile Lys Leu Lys Gln Lys Ile Tyr Glu Asp Leu Phe Lys Lys 
                565                 570                 575     


Tyr Lys Lys Ile Thr Gln Lys Gln Ile Ser Thr Phe Ile Lys His Glu 
            580                 585                 590         


Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 
        595                 600                 605             


Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 
    610                 615                 620                 


Gly Lys Gln Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 
625                 630                 635                 640 


Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 
                645                 650                 655     


Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gln 
            660                 665                 670         


Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 
        675                 680                 685             


Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 
    690                 695                 700                 


Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gln Asn Asn Leu Met 
705                 710                 715                 720 


Glu Leu Leu Ser Ser Glu Phe Thr Phe Thr Glu Asn Ile Lys Lys Ile 
                725                 730                 735     


Asn Ser Gly Phe Glu Asp Ala Glu Lys Gln Phe Ser Tyr Asp Gly Leu 
            740                 745                 750         


Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gln 
        755                 760                 765             


Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gln Ala Pro Pro 
    770                 775                 780                 


Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Glu Pro Ala 
785                 790                 795                 800 


Arg Thr Lys Thr Arg Leu Lys Ile Leu Gln Asp Leu Tyr Asn Asn Cys 
                805                 810                 815     


Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Lys Asp Leu Ser Gly 
            820                 825                 830         


Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser Asp Lys Leu Tyr 
        835                 840                 845             


Leu Tyr Tyr Thr Gln Leu Gly Lys Cys Met Tyr Cys Gly Lys Pro Ile 
    850                 855                 860                 


Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp Ile Asp His Ile 
865                 870                 875                 880 


Tyr Pro Gln Ser Lys Ile Lys Asp Asp Ser Ile Ser Asn Arg Val Leu 
                885                 890                 895     


Val Cys Ser Ser Cys Asn Lys Asn Lys Glu Asp Lys Tyr Pro Leu Lys 
            900                 905                 910         


Ser Glu Ile Gln Ser Lys Gln Arg Gly Phe Trp Asn Phe Leu Gln Arg 
        915                 920                 925             


Asn Asn Phe Ile Ser Leu Glu Lys Leu Asn Arg Leu Thr Arg Ala Thr 
    930                 935                 940                 


Pro Ile Ser Asp Asp Glu Thr Ala Lys Phe Ile Ala Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ala Thr Lys Val Ala Ala Lys Val Leu Glu Lys Met 
                965                 970                 975     


Phe Pro Glu Thr Lys Ile Val Tyr Ser Lys Ala Glu Thr Val Ser Met 
            980                 985                 990         


Phe Arg Asn Lys Phe Asp Ile Val  Lys Cys Arg Glu Ile  Asn Asp Phe 
        995                 1000                 1005             


His His  Ala His Asp Ala Tyr  Leu Asn Ile Val Val  Gly Asn Val 
    1010                 1015                 1020             


Tyr Asn  Thr Lys Phe Thr Asn  Asn Pro Trp Asn Phe  Ile Lys Glu 
    1025                 1030                 1035             


Lys Arg  Asp Asn Pro Lys Ile  Ala Asp Thr Tyr Asn  Tyr Tyr Lys 
    1040                 1045                 1050             


Val Phe  Asp Tyr Asp Val Lys  Arg Asn Asn Ile Thr  Ala Trp Glu 
    1055                 1060                 1065             


Lys Gly  Lys Thr Ile Ile Thr  Val Lys Asp Met Leu  Lys Arg Asn 
    1070                 1075                 1080             


Thr Pro  Ile Tyr Thr Arg Gln  Ala Ala Cys Lys Lys  Gly Glu Leu 
    1085                 1090                 1095             


Phe Asn  Gln Thr Ile Met Lys  Lys Gly Leu Gly Gln  His Pro Leu 
    1100                 1105                 1110             


Lys Lys  Glu Gly Pro Phe Ser  Asn Ile Ser Lys Tyr  Gly Gly Tyr 
    1115                 1120                 1125             


Asn Lys  Val Ser Ala Ala Tyr  Tyr Thr Leu Ile Glu  Tyr Glu Glu 
    1130                 1135                 1140             


Lys Gly  Asn Lys Ile Arg Ser  Leu Glu Thr Ile Pro  Leu Tyr Leu 
    1145                 1150                 1155             


Val Lys  Asp Ile Gln Lys Asp  Gln Asp Val Leu Lys  Ser Tyr Leu 
    1160                 1165                 1170             


Thr Asp  Leu Leu Gly Lys Lys  Glu Phe Lys Ile Leu  Val Pro Lys 
    1175                 1180                 1185             


Ile Lys  Ile Asn Ser Leu Leu  Lys Ile Asn Gly Phe  Pro Cys His 
    1190                 1195                 1200             


Ile Thr  Gly Lys Thr Asn Asp  Ser Phe Leu Leu Arg  Pro Ala Val 
    1205                 1210                 1215             


Gln Phe  Cys Cys Ser Asn Asn  Glu Val Leu Tyr Phe  Lys Lys Ile 
    1220                 1225                 1230             


Ile Arg  Phe Ser Glu Ile Arg  Ser Gln Arg Glu Lys  Ile Gly Lys 
    1235                 1240                 1245             


Thr Ile  Ser Pro Tyr Glu Asp  Leu Ser Phe Arg Ser  Tyr Ile Lys 
    1250                 1255                 1260             


Glu Asn  Leu Trp Lys Lys Thr  Lys Asn Asp Glu Ile  Gly Glu Lys 
    1265                 1270                 1275             


Glu Phe  Tyr Asp Leu Leu Gln  Lys Lys Asn Leu Glu  Ile Tyr Asp 
    1280                 1285                 1290             


Met Leu  Leu Thr Lys His Lys  Asp Thr Ile Tyr Lys  Lys Arg Pro 
    1295                 1300                 1305             


Asn Ser  Ala Thr Ile Asp Ile  Leu Val Lys Gly Lys  Glu Lys Phe 
    1310                 1315                 1320             


Lys Ser  Leu Ile Ile Glu Asn  Gln Phe Glu Val Ile  Leu Glu Ile 
    1325                 1330                 1335             


Leu Lys  Leu Phe Ser Ala Thr  Arg Asn Val Ser Asp  Leu Gln His 
    1340                 1345                 1350             


Ile Gly  Gly Ser Lys Tyr Ser  Gly Val Ala Lys Ile  Gly Asn Lys 
    1355                 1360                 1365             


Ile Ser  Ser Leu Asp Asn Cys  Ile Leu Ile Tyr Gln  Ser Ile Thr 
    1370                 1375                 1380             


Gly Ile  Phe Glu Lys Arg Ile  Asp Leu Leu Lys Val  
    1385                 1390                 1395 


<210> 605
<211> 1395
<212> PRT
<213> Treponema denticola


<220>
<223> Treponema denticola H1-T

<400> 605
Met Lys Lys Glu Ile Lys Asp Tyr Phe Leu Gly Leu Asp Val Gly Thr 
1               5                   10                  15      


Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 
            20                  25                  30          


Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 
        35                  40                  45              


Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 
    50                  55                  60                  


Arg Arg Lys Lys Arg Ile Lys Leu Leu Gln Glu Leu Phe Ser Gln Glu 
65                  70                  75                  80  


Ile Ala Lys Ile Asp Glu Gly Phe Phe Gln Arg Met Lys Glu Ser Pro 
                85                  90                  95      


Phe Tyr Ala Glu Asp Lys Thr Ile Leu Gln Glu Asn Ala Leu Phe Asn 
            100                 105                 110         


Asp Lys Asp Phe Thr Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 
        115                 120                 125             


Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 
    130                 135                 140                 


Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 
145                 150                 155                 160 


Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gln Phe Asp Thr Ser 
                165                 170                 175     


Ile Gln Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 
            180                 185                 190         


Asp Ala Asp Ser Gln Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 
        195                 200                 205             


Lys Asn Ser Glu Lys Gln Ser Arg Leu Asn Lys Ile Leu Gly Leu Lys 
    210                 215                 220                 


Pro Ser Asp Lys Gln Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 
225                 230                 235                 240 


Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 
                245                 250                 255     


Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 
            260                 265                 270         


Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 
        275                 280                 285             


Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 
    290                 295                 300                 


Glu Gln Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 
305                 310                 315                 320 


Thr Asp Leu Thr Lys Leu Lys Ala Val Ile Lys Lys His Phe Pro Asn 
                325                 330                 335     


Asn Tyr Lys Lys Val Phe Gly Tyr Asn Gln Asp Asn Glu Ser Lys Asn 
            340                 345                 350         


Asn Tyr Ser Gly Tyr Val Gly Val Cys Lys Thr Lys Asn Lys Lys Leu 
        355                 360                 365             


Val Ile Asn Asn Ser Val Asn Gln Glu Asp Phe Tyr Lys Phe Leu Lys 
    370                 375                 380                 


Pro Ile Leu Ser Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 
385                 390                 395                 400 


Ala Glu Ile Glu Thr Gly Asn Phe Leu Pro Lys Gln Ile Ser Lys Ser 
                405                 410                 415     


Asn Ala Glu Ile Pro Tyr Gln Leu Arg Lys Met Glu Leu Glu Lys Ile 
            420                 425                 430         


Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gln Lys Asp Glu 
        435                 440                 445             


Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 
    450                 455                 460                 


Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Ser Phe 
465                 470                 475                 480 


Pro Asp Arg Cys Trp Val Val Lys Lys Glu Lys Ser Pro Ser Gly Lys 
                485                 490                 495     


Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Glu Lys Thr Ala 
            500                 505                 510         


Glu Glu Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Ile Gly 
        515                 520                 525             


Glu Ser Val Leu Pro Lys Asn Ser Leu Leu Tyr Ser Glu Tyr Thr Val 
    530                 535                 540                 


Leu Asn Glu Ile Asn Asn Leu Gln Ile Ile Ile Asp Gly Lys Asn Ile 
545                 550                 555                 560 


Cys Asp Thr Lys Leu Lys Gln Lys Ile Tyr Glu Asp Leu Phe Lys Lys 
                565                 570                 575     


Tyr Lys Lys Ile Thr Gln Lys Gln Ile Ser Thr Phe Ile Lys His Glu 
            580                 585                 590         


Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 
        595                 600                 605             


Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 
    610                 615                 620                 


Gly Lys Gln Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 
625                 630                 635                 640 


Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 
                645                 650                 655     


Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gln 
            660                 665                 670         


Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 
        675                 680                 685             


Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 
    690                 695                 700                 


Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gln Asn Asn Leu Met 
705                 710                 715                 720 


Glu Leu Leu Ser Ser Glu Phe Lys Phe Thr Glu Asn Ile Lys Lys Ile 
                725                 730                 735     


Asn Ser Gly Phe Glu Asp Ala Glu Lys Gln Phe Ser Tyr Asp Gly Leu 
            740                 745                 750         


Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gln 
        755                 760                 765             


Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gln Ala Pro Pro 
    770                 775                 780                 


Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Glu Pro Ala 
785                 790                 795                 800 


Arg Thr Lys Thr Arg Leu Lys Ile Leu Gln Asp Leu Tyr Ser Ser Cys 
                805                 810                 815     


Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Gln Tyr Leu Ser Gly 
            820                 825                 830         


Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser Asp Lys Leu Tyr 
        835                 840                 845             


Leu Tyr Tyr Thr Gln Leu Gly Lys Cys Met Tyr Cys Gly Lys Pro Ile 
    850                 855                 860                 


Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp Ile Asp His Ile 
865                 870                 875                 880 


Tyr Pro Gln Ser Lys Ile Lys Asp Asp Ser Ile Ser Asn Arg Val Leu 
                885                 890                 895     


Val Cys Ser Ser Cys Asn Lys Asn Lys Glu Asp Lys Tyr Pro Leu Lys 
            900                 905                 910         


Ser Glu Ile Gln Ser Lys Gln Arg Gly Phe Trp Asn Phe Leu Gln Arg 
        915                 920                 925             


Asn Asn Phe Ile Ser Leu Glu Lys Leu Asn Arg Leu Thr Arg Thr Thr 
    930                 935                 940                 


Pro Ile Ser Asp Asp Glu Thr Ala Lys Phe Ile Ala Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ala Thr Lys Val Ala Ala Lys Val Leu Glu Lys Met 
                965                 970                 975     


Phe Pro Glu Thr Lys Ile Val Tyr Ser Lys Ala Glu Thr Val Ser Met 
            980                 985                 990         


Phe Arg Asn Lys Phe Asp Ile Ile  Lys Cys Arg Glu Ile  Asn Asp Phe 
        995                 1000                 1005             


His His  Ala His Asp Ala Tyr  Leu Asn Ile Val Val  Gly Asn Val 
    1010                 1015                 1020             


Tyr Asn  Thr Lys Phe Thr Asn  Asn Pro Trp Asn Phe  Ile Lys Glu 
    1025                 1030                 1035             


Lys Arg  Asp Asn Pro Lys Ile  Ala Asp Thr Tyr Asn  Tyr Tyr Lys 
    1040                 1045                 1050             


Val Phe  Asp Tyr Asp Val Lys  Arg Asn Asn Ile Thr  Ala Trp Glu 
    1055                 1060                 1065             


Lys Gly  Lys Thr Ile Ile Thr  Val Lys Asp Met Leu  Lys Arg Asn 
    1070                 1075                 1080             


Thr Pro  Ile Tyr Thr Arg Gln  Ala Ala Cys Lys Lys  Gly Glu Leu 
    1085                 1090                 1095             


Phe Asn  Gln Thr Ile Met Lys  Lys Gly Leu Gly Gln  His Pro Leu 
    1100                 1105                 1110             


Lys Lys  Glu Gly Pro Phe Ser  Asn Ile Ser Lys Tyr  Gly Gly Tyr 
    1115                 1120                 1125             


Asn Lys  Val Ser Ala Ala Tyr  Tyr Thr Leu Ile Glu  Tyr Glu Glu 
    1130                 1135                 1140             


Lys Val  Asn Lys Ile Arg Ser  Leu Glu Thr Ile Pro  Leu Tyr Leu 
    1145                 1150                 1155             


Val Lys  Asp Ile Gln Lys Asp  Gln Asp Val Leu Lys  Ser Tyr Leu 
    1160                 1165                 1170             


Thr Asp  Leu Leu Gly Lys Lys  Glu Ile Lys Ile Leu  Val Pro Lys 
    1175                 1180                 1185             


Ile Lys  Ile Asn Ser Leu Leu  Lys Ile Asn Gly Phe  Pro Cys His 
    1190                 1195                 1200             


Ile Thr  Gly Lys Thr Gly Asp  Ser Phe Val Leu Arg  Pro Ala Val 
    1205                 1210                 1215             


Gln Phe  Cys Cys Ser Asn Asp  Glu Val Leu Tyr Phe  Lys Lys Ile 
    1220                 1225                 1230             


Ile Arg  Phe Asn Glu Ile Arg  Ser Gln Arg Glu Lys  Met Gly Lys 
    1235                 1240                 1245             


Thr Ile  Ser Pro Tyr Glu Asp  Leu Ser Phe Arg Ser  Tyr Ile Lys 
    1250                 1255                 1260             


Glu Asn  Leu Cys Lys Lys Thr  Lys Ala Asp Glu Ile  Gly Glu Lys 
    1265                 1270                 1275             


Glu Phe  Tyr Asp Leu Leu Gln  Lys Lys Asn Leu Glu  Ile Tyr Asp 
    1280                 1285                 1290             


Met Leu  Leu Thr Lys His Lys  Asp Thr Ile Tyr Asn  Lys Arg Pro 
    1295                 1300                 1305             


Asn Ser  Thr Thr Leu Gly Met  Leu Thr Lys Gly Arg  Tyr Glu Phe 
    1310                 1315                 1320             


Ile Asn  Leu Lys Pro Lys Asp  Gln Ile Ile Val Met  Leu Glu Ile 
    1325                 1330                 1335             


Leu Lys  Leu Phe Cys Thr Thr  Arg Glu Ala Ile Asp  Leu Gly Leu 
    1340                 1345                 1350             


Ile Lys  Gly Lys Pro Ala Ala  Gly Val Ala Thr Leu  Gly Lys Lys 
    1355                 1360                 1365             


Ile Ser  Asn Leu Asp Asn Cys  Ile Leu Ile Tyr Gln  Ser Ile Thr 
    1370                 1375                 1380             


Gly Ile  Phe Glu Lys Arg Ile  Asp Leu Leu Lys Val  
    1385                 1390                 1395 


<210> 606
<211> 1395
<212> PRT
<213> Treponema denticola


<220>
<223> Treponema denticola H-22

<400> 606
Met Lys Lys Glu Ile Lys Asp Tyr Phe Leu Gly Leu Asp Val Gly Thr 
1               5                   10                  15      


Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 
            20                  25                  30          


Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 
        35                  40                  45              


Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 
    50                  55                  60                  


Arg Arg Lys Lys Arg Ile Lys Leu Leu Gln Glu Leu Phe Ser Gln Glu 
65                  70                  75                  80  


Ile Ala Lys Ile Asp Glu Gly Phe Phe Gln Arg Met Lys Glu Ser Pro 
                85                  90                  95      


Phe Tyr Ala Glu Asp Lys Thr Ile Leu Gln Glu Asn Thr Leu Phe Asn 
            100                 105                 110         


Asp Lys Asp Phe Thr Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 
        115                 120                 125             


Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 
    130                 135                 140                 


Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 
145                 150                 155                 160 


Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gln Phe Asp Thr Ser 
                165                 170                 175     


Ile Gln Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 
            180                 185                 190         


Asp Ala Asp Ser Gln Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 
        195                 200                 205             


Lys Asn Ser Glu Lys Gln Ser Arg Leu Asn Lys Ile Leu Gly Leu Lys 
    210                 215                 220                 


Pro Ser Asp Lys Gln Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 
225                 230                 235                 240 


Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 
                245                 250                 255     


Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 
            260                 265                 270         


Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 
        275                 280                 285             


Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 
    290                 295                 300                 


Glu Gln Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 
305                 310                 315                 320 


Thr Asp Leu Thr Lys Leu Lys Asn Val Ile Lys Lys His Phe Pro Lys 
                325                 330                 335     


Asp Tyr Lys Lys Val Phe Gly Tyr Asn Lys Asn Glu Lys Asn Asn Asn 
            340                 345                 350         


Asn Tyr Ser Gly Tyr Val Gly Val Cys Lys Thr Lys Ser Lys Lys Leu 
        355                 360                 365             


Ile Ile Asn Asn Ser Val Asn Gln Glu Asp Phe Tyr Lys Phe Leu Lys 
    370                 375                 380                 


Thr Ile Leu Ser Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 
385                 390                 395                 400 


Thr Glu Ile Glu Thr Gly Thr Phe Leu Pro Lys Gln Ile Ser Lys Ser 
                405                 410                 415     


Asn Ala Glu Ile Pro Tyr Gln Leu Arg Lys Met Glu Leu Glu Lys Ile 
            420                 425                 430         


Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gln Lys Asp Glu 
        435                 440                 445             


Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 
    450                 455                 460                 


Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Ser Phe 
465                 470                 475                 480 


Pro Asp Arg Cys Trp Val Ile Lys Lys Glu Lys Ser Pro Ser Gly Lys 
                485                 490                 495     


Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Asp Lys Thr Ala 
            500                 505                 510         


Glu Ala Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Val Gly 
        515                 520                 525             


Glu Ser Val Leu Pro Lys Ser Ser Leu Leu Tyr Ser Glu Tyr Thr Val 
    530                 535                 540                 


Leu Asn Glu Ile Asn Asn Leu Gln Ile Ile Ile Asp Gly Lys Asn Ile 
545                 550                 555                 560 


Cys Asp Ile Lys Leu Lys Gln Lys Ile Tyr Glu Glu Leu Phe Lys Lys 
                565                 570                 575     


Tyr Lys Lys Ile Thr Gln Lys Gln Ile Ser Thr Phe Ile Lys His Glu 
            580                 585                 590         


Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 
        595                 600                 605             


Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 
    610                 615                 620                 


Gly Lys Gln Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 
625                 630                 635                 640 


Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 
                645                 650                 655     


Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gln 
            660                 665                 670         


Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 
        675                 680                 685             


Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 
    690                 695                 700                 


Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gln Asn Asn Leu Met 
705                 710                 715                 720 


Glu Leu Leu Ser Ser Glu Phe Lys Phe Thr Glu Asn Ile Lys Lys Ile 
                725                 730                 735     


Asn Ser Gly Phe Glu Asp Ala Glu Lys Gln Phe Ser Tyr Asn Gly Leu 
            740                 745                 750         


Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gln 
        755                 760                 765             


Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gln Ala Pro Pro 
    770                 775                 780                 


Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Glu Pro Ala 
785                 790                 795                 800 


Arg Thr Lys Thr Arg Leu Lys Ile Leu Gln Asp Leu Tyr Asn Asn Cys 
                805                 810                 815     


Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Lys Asp Leu Ser Gly 
            820                 825                 830         


Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser Asp Lys Leu Tyr 
        835                 840                 845             


Leu Tyr Tyr Thr Gln Leu Gly Lys Cys Met Tyr Cys Gly Lys Pro Ile 
    850                 855                 860                 


Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp Ile Asp His Ile 
865                 870                 875                 880 


Tyr Pro Gln Ser Lys Ile Lys Asp Asp Ser Ile Ser Asn Arg Val Leu 
                885                 890                 895     


Val Cys Ser Ser Cys Asn Lys Asn Lys Glu Asp Lys Tyr Pro Leu Lys 
            900                 905                 910         


Ser Glu Ile Gln Ser Lys Gln Arg Gly Phe Trp Asn Phe Leu Gln Arg 
        915                 920                 925             


Asn Asn Phe Ile Ser Leu Glu Lys Leu Asn Arg Leu Thr Arg Thr Thr 
    930                 935                 940                 


Pro Ile Ser Asp Asp Glu Thr Ala Lys Phe Ile Ala Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ala Thr Lys Val Ala Ala Lys Val Leu Glu Lys Met 
                965                 970                 975     


Phe Pro Glu Thr Lys Ile Val Tyr Ser Lys Ala Glu Thr Val Ser Met 
            980                 985                 990         


Phe Arg Asn Lys Phe Asp Ile Ile  Lys Cys Arg Glu Ile  Asn Asp Phe 
        995                 1000                 1005             


His His  Ala His Asp Ala Tyr  Leu Asn Ile Val Val  Gly Asn Val 
    1010                 1015                 1020             


Tyr Asn  Thr Lys Phe Thr Asn  Asn Pro Trp Asn Phe  Ile Lys Glu 
    1025                 1030                 1035             


Lys Arg  Asp Asn Pro Lys Ile  Ala Asp Thr Tyr Asn  Tyr Tyr Lys 
    1040                 1045                 1050             


Val Phe  Asp Tyr Asp Val Lys  Arg Asn Asn Ile Thr  Ala Trp Glu 
    1055                 1060                 1065             


Lys Gly  Lys Thr Ile Ile Thr  Val Lys Asp Met Leu  Lys Arg Asn 
    1070                 1075                 1080             


Thr Pro  Ile Tyr Thr Arg Gln  Ala Ala Cys Lys Lys  Gly Gly Leu 
    1085                 1090                 1095             


Phe Asp  Gln Thr Ile Met Lys  Lys Gly Leu Gly Gln  His Pro Leu 
    1100                 1105                 1110             


Lys Lys  Glu Gly Ala Phe Ser  Asn Ile Ser Lys Tyr  Gly Gly Tyr 
    1115                 1120                 1125             


Asn Lys  Val Ser Ala Ala Tyr  Tyr Thr Leu Ile Glu  Tyr Glu Glu 
    1130                 1135                 1140             


Lys Gly  Asn Lys Ile Arg Ser  Leu Glu Thr Ile Pro  Leu Tyr Leu 
    1145                 1150                 1155             


Val Lys  Asp Ile Gln Lys Asp  Gln Asp Val Leu Lys  Ser Tyr Leu 
    1160                 1165                 1170             


Thr Asp  Leu Leu Gly Lys Lys  Glu Ile Lys Ile Leu  Val Pro Lys 
    1175                 1180                 1185             


Ile Lys  Ile Asn Ser Leu Leu  Lys Ile Asn Gly Phe  Pro Cys His 
    1190                 1195                 1200             


Ile Thr  Gly Lys Thr Gly Asp  Ser Phe Val Leu Arg  Pro Ala Val 
    1205                 1210                 1215             


Gln Phe  Cys Cys Ser Asn Asp  Glu Val Leu Tyr Phe  Lys Lys Ile 
    1220                 1225                 1230             


Ile Arg  Phe Asn Glu Ile Arg  Ser Gln Arg Glu Lys  Met Gly Lys 
    1235                 1240                 1245             


Thr Ile  Ser Pro Tyr Glu Asp  Leu Ser Phe Arg Ser  Tyr Ile Lys 
    1250                 1255                 1260             


Glu Asn  Leu Cys Lys Lys Thr  Lys Ala Asp Glu Ile  Gly Glu Lys 
    1265                 1270                 1275             


Glu Phe  Tyr Asp Leu Leu Gln  Lys Lys Asn Leu Glu  Ile Tyr Asp 
    1280                 1285                 1290             


Met Leu  Leu Thr Lys His Lys  Asp Thr Ile Tyr Asn  Lys Arg Pro 
    1295                 1300                 1305             


Asn Ser  Thr Thr Leu Gly Met  Leu Thr Lys Gly Arg  Tyr Glu Phe 
    1310                 1315                 1320             


Ile Asn  Leu Lys Pro Lys Asp  Gln Ile Ile Val Met  Leu Glu Ile 
    1325                 1330                 1335             


Leu Lys  Leu Phe Cys Thr Thr  Arg Glu Ala Ile Asp  Leu Gly Leu 
    1340                 1345                 1350             


Ile Lys  Gly Lys Pro Ala Ala  Gly Val Ala Thr Leu  Gly Lys Lys 
    1355                 1360                 1365             


Ile Ser  Asn Pro Asp Asn Cys  Ile Leu Ile Tyr Gln  Ser Ile Thr 
    1370                 1375                 1380             


Gly Ile  Phe Glu Lys Arg Ile  Asp Leu Leu Lys Val  
    1385                 1390                 1395 


<210> 607
<211> 1395
<212> PRT
<213> Treponema denticola


<220>
<223> Treponema denticola OTK

<400> 607
Met Lys Lys Glu Ile Lys Asp Tyr Phe Leu Gly Leu Asp Val Gly Thr 
1               5                   10                  15      


Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 
            20                  25                  30          


Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 
        35                  40                  45              


Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 
    50                  55                  60                  


Arg Arg Lys Lys Arg Ile Lys Leu Leu Gln Glu Leu Phe Ser Gln Glu 
65                  70                  75                  80  


Ile Ala Lys Ile Asp Glu Gly Phe Phe Gln Arg Met Lys Glu Ser Pro 
                85                  90                  95      


Leu Tyr Ala Glu Asp Lys Thr Ile Leu Gln Glu Asn Thr Leu Phe Asn 
            100                 105                 110         


Asp Lys Asp Phe Thr Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 
        115                 120                 125             


Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 
    130                 135                 140                 


Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 
145                 150                 155                 160 


Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gln Phe Asp Thr Ser 
                165                 170                 175     


Ile Gln Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Leu Asp Ile 
            180                 185                 190         


Asp Ala Asp Ser Gln Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 
        195                 200                 205             


Lys Asn Ser Glu Lys Gln Ser Arg Leu Asn Lys Met Leu Gly Leu Lys 
    210                 215                 220                 


Pro Ser Asp Lys Gln Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 
225                 230                 235                 240 


Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 
                245                 250                 255     


Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 
            260                 265                 270         


Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 
        275                 280                 285             


Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 
    290                 295                 300                 


Glu Gln Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 
305                 310                 315                 320 


Thr Asp Leu Thr Lys Leu Lys Asn Val Ile Lys Lys His Phe Pro Lys 
                325                 330                 335     


Asp Tyr Lys Lys Val Phe Gly Tyr Asn Lys Asn Glu Lys Asn Asn Asn 
            340                 345                 350         


Asn Tyr Ser Ala Tyr Val Gly Val Cys Lys Ile Thr His Lys Lys Leu 
        355                 360                 365             


Val Ile Lys Asn Ser Ala Ser Gln Glu Asp Phe Tyr Lys Phe Leu Lys 
    370                 375                 380                 


Thr Ile Leu Ser Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 
385                 390                 395                 400 


Thr Glu Ile Glu Thr Gly Thr Phe Leu Pro Lys Gln Ile Ser Lys Ser 
                405                 410                 415     


Asn Ala Glu Ile Pro Tyr Gln Leu Arg Lys Met Glu Leu Glu Lys Ile 
            420                 425                 430         


Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gln Lys Asp Glu 
        435                 440                 445             


Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 
    450                 455                 460                 


Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Ser Phe 
465                 470                 475                 480 


Pro Asp Arg Cys Trp Val Val Lys Lys Glu Lys Ser Pro Ser Gly Lys 
                485                 490                 495     


Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Glu Lys Thr Ala 
            500                 505                 510         


Glu Glu Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Ile Gly 
        515                 520                 525             


Glu Ser Val Leu Pro Lys Ser Ser Leu Leu Tyr Ser Glu Tyr Thr Val 
    530                 535                 540                 


Leu Asn Glu Ile Asn Asn Leu Gln Ile Ile Ile Asp Gly Lys Asn Ile 
545                 550                 555                 560 


Cys Asp Ile Lys Leu Lys Gln Lys Ile Tyr Glu Glu Leu Phe Lys Lys 
                565                 570                 575     


Tyr Lys Lys Ile Thr Gln Lys Gln Ile Ser Thr Phe Ile Lys His Glu 
            580                 585                 590         


Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 
        595                 600                 605             


Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 
    610                 615                 620                 


Gly Lys Gln Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 
625                 630                 635                 640 


Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 
                645                 650                 655     


Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gln 
            660                 665                 670         


Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 
        675                 680                 685             


Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 
    690                 695                 700                 


Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gln Asn Asn Leu Met 
705                 710                 715                 720 


Glu Leu Leu Ser Ser Glu Phe Lys Phe Thr Glu Asn Ile Lys Lys Ile 
                725                 730                 735     


Asn Ser Gly Phe Glu Asp Ala Glu Lys Gln Phe Ser Tyr Asn Gly Leu 
            740                 745                 750         


Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gln 
        755                 760                 765             


Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gln Ala Pro Pro 
    770                 775                 780                 


Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Glu Pro Ala 
785                 790                 795                 800 


Arg Thr Lys Thr Arg Leu Lys Ile Leu Gln Asp Leu Tyr Ser Ser Cys 
                805                 810                 815     


Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Gln Tyr Leu Ser Gly 
            820                 825                 830         


Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser Asp Lys Leu Tyr 
        835                 840                 845             


Leu Tyr Tyr Thr Gln Leu Gly Lys Cys Met Tyr Cys Gly Lys Pro Ile 
    850                 855                 860                 


Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp Ile Asp His Ile 
865                 870                 875                 880 


Tyr Pro Gln Ser Lys Ile Lys Asp Asp Ser Ile Ser Asn Arg Val Leu 
                885                 890                 895     


Val Cys Ser Ser Cys Asn Lys Asn Lys Glu Asp Lys Tyr Pro Leu Lys 
            900                 905                 910         


Ala Glu Ile Gln Ser Lys Gln Arg Gly Phe Trp Asn Phe Leu Gln Arg 
        915                 920                 925             


Asn Asn Phe Ile Ser Leu Glu Lys Leu Asn Arg Leu Thr Arg Thr Ser 
    930                 935                 940                 


Pro Ile Ser Asp Asp Glu Thr Ala Lys Phe Ile Ala Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ala Thr Lys Val Ala Ala Lys Val Leu Glu Lys Met 
                965                 970                 975     


Phe Pro Glu Thr Lys Ile Val Tyr Ser Lys Ala Glu Thr Val Ser Met 
            980                 985                 990         


Phe Arg Asn Lys Phe Asp Ile Ile  Lys Cys Arg Glu Ile  Asn Asp Phe 
        995                 1000                 1005             


His His  Ala His Asp Ala Tyr  Leu Asn Ile Val Val  Gly Asn Val 
    1010                 1015                 1020             


Tyr Asn  Thr Lys Phe Thr Asn  Asn Pro Trp Asn Phe  Ile Lys Glu 
    1025                 1030                 1035             


Lys Arg  Asp Asn Pro Lys Ile  Ala Asp Thr Tyr Asn  Tyr Tyr Lys 
    1040                 1045                 1050             


Val Phe  Asp Tyr Asp Val Lys  Arg Asn Asn Ile Thr  Ala Trp Glu 
    1055                 1060                 1065             


Lys Gly  Lys Thr Ile Ile Thr  Val Lys Asp Met Leu  Lys Arg Asn 
    1070                 1075                 1080             


Thr Pro  Ile Tyr Thr Arg Gln  Ala Ala Cys Lys Lys  Gly Glu Leu 
    1085                 1090                 1095             


Phe Asn  Gln Thr Ile Met Lys  Lys Gly Leu Gly Gln  His Pro Leu 
    1100                 1105                 1110             


Lys Lys  Glu Gly Pro Leu Ser  Asn Ile Ser Lys Tyr  Gly Gly Tyr 
    1115                 1120                 1125             


Asn Lys  Val Ser Ala Ala Tyr  Tyr Thr Leu Ile Glu  Tyr Glu Glu 
    1130                 1135                 1140             


Lys Gly  Ser Lys Ile Arg Ser  Leu Glu Thr Ile Pro  Leu Tyr Leu 
    1145                 1150                 1155             


Val Lys  Asp Ile Gln Lys Asn  Lys Asp Gly Leu Lys  Ser Tyr Leu 
    1160                 1165                 1170             


Thr Asp  Gln Ile Gly Lys Lys  Glu Ile Lys Ile Leu  Ile Pro Lys 
    1175                 1180                 1185             


Ile Lys  Ile Asn Ser Leu Leu  Lys Ile Asn Gly Phe  Pro Cys His 
    1190                 1195                 1200             


Ile Thr  Gly Lys Met Gly Glu  Ala Phe Val Leu Arg  Pro Ala Val 
    1205                 1210                 1215             


Gln Phe  Cys Cys Ser Asn Asp  Glu Ala Leu Tyr Phe  Lys Lys Ile 
    1220                 1225                 1230             


Ile Arg  Phe Asn Glu Ile Arg  Lys Gln Arg Glu Lys  Met Gly Lys 
    1235                 1240                 1245             


Thr Ile  Ser Pro Tyr Glu Asp  Leu Ser Phe Arg Ser  Tyr Ile Lys 
    1250                 1255                 1260             


Asp Asn  Leu Cys Lys Lys Thr  Lys Ala Asp Glu Ile  Glu Glu Lys 
    1265                 1270                 1275             


Glu Phe  Tyr Asp Leu Leu Gln  Lys Lys Asn Leu Glu  Ile Tyr Asp 
    1280                 1285                 1290             


Met Leu  Leu Thr Lys His Lys  Asp Thr Ile Tyr Lys  Lys Arg Pro 
    1295                 1300                 1305             


Asn Ser  Ala Thr Ile Asp Ile  Leu Val Lys Gly Lys  Glu Lys Phe 
    1310                 1315                 1320             


Lys Ser  Leu Ile Ile Glu Asn  Gln Phe Glu Val Ile  Leu Glu Ile 
    1325                 1330                 1335             


Leu Lys  Leu Phe Ser Ala Thr  Arg Asn Val Ser Asp  Leu Gln His 
    1340                 1345                 1350             


Ile Gly  Gly Ser Lys Asn Ala  Gly Asn Ala Arg Val  Gly Asn Lys 
    1355                 1360                 1365             


Ile Ser  Ser Leu Asp Asn Cys  Ile Leu Ile Tyr Gln  Ser Ile Thr 
    1370                 1375                 1380             


Gly Ile  Phe Glu Lys Arg Ile  Asp Leu Leu Lys Ile  
    1385                 1390                 1395 


<210> 608
<211> 1395
<212> PRT
<213> Treponema denticola


<220>
<223> Treponema denticola SP37

<400> 608
Met Lys Lys Glu Ile Lys Asp Tyr Phe Leu Gly Leu Asp Val Gly Thr 
1               5                   10                  15      


Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 
            20                  25                  30          


Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 
        35                  40                  45              


Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 
    50                  55                  60                  


Arg Arg Lys Lys Arg Ile Lys Leu Leu Gln Glu Leu Phe Ser Gln Glu 
65                  70                  75                  80  


Ile Ala Lys Thr Asp Glu Gly Phe Phe Gln Arg Met Lys Glu Ser Pro 
                85                  90                  95      


Phe Tyr Ala Glu Asp Lys Thr Ile Leu Gln Glu Asn Ala Leu Phe Asn 
            100                 105                 110         


Asp Arg Asp Phe Thr Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 
        115                 120                 125             


Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 
    130                 135                 140                 


Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 
145                 150                 155                 160 


Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gln Phe Asp Thr Ser 
                165                 170                 175     


Ile Gln Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 
            180                 185                 190         


Asp Ala Asp Ser Gln Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 
        195                 200                 205             


Lys Asn Ser Glu Lys Gln Ser Arg Leu Asn Lys Met Leu Gly Leu Lys 
    210                 215                 220                 


Pro Ser Asp Lys Gln Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 
225                 230                 235                 240 


Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 
                245                 250                 255     


Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 
            260                 265                 270         


Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 
        275                 280                 285             


Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 
    290                 295                 300                 


Glu Gln Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 
305                 310                 315                 320 


Thr Asp Leu Thr Lys Leu Lys Asn Val Ile Lys Lys His Phe Pro Asn 
                325                 330                 335     


Asp Tyr Lys Lys Val Phe Gly Tyr Asn Lys Asn Glu Lys Asn Asn Asn 
            340                 345                 350         


Asn Tyr Ser Ala Tyr Val Gly Val Cys Lys Thr Lys Ser Lys Lys Leu 
        355                 360                 365             


Val Ile Asn Asn Thr Val Asn Gln Glu Asp Phe Tyr Lys Phe Leu Lys 
    370                 375                 380                 


Pro Ile Leu Leu Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 
385                 390                 395                 400 


Thr Glu Ile Glu Thr Gly Thr Phe Leu Pro Lys Gln Ile Ser Lys Ser 
                405                 410                 415     


Asn Ala Glu Ile Pro Tyr Gln Leu Arg Lys Met Glu Leu Glu Lys Ile 
            420                 425                 430         


Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gln Lys Asp Glu 
        435                 440                 445             


Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 
    450                 455                 460                 


Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Ser Phe 
465                 470                 475                 480 


Pro Asp Arg Cys Trp Val Ile Lys Lys Glu Lys Ser Pro Ser Gly Lys 
                485                 490                 495     


Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Asp Lys Thr Ala 
            500                 505                 510         


Glu Ala Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Val Gly 
        515                 520                 525             


Glu Ser Val Leu Pro Lys Asn Ser Leu Leu Tyr Ser Glu Tyr Thr Val 
    530                 535                 540                 


Leu Asn Glu Ile Asn Asn Leu Gln Ile Ile Ile Asp Gly Lys Asn Ile 
545                 550                 555                 560 


Cys Asp Ile Lys Leu Lys Gln Lys Ile Tyr Glu Glu Leu Phe Lys Lys 
                565                 570                 575     


Tyr Lys Lys Ile Thr Gln Lys Gln Ile Ser Thr Phe Ile Lys His Glu 
            580                 585                 590         


Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 
        595                 600                 605             


Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 
    610                 615                 620                 


Gly Lys Gln Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 
625                 630                 635                 640 


Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 
                645                 650                 655     


Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gln 
            660                 665                 670         


Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 
        675                 680                 685             


Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 
    690                 695                 700                 


Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gln Asn Asn Leu Met 
705                 710                 715                 720 


Glu Leu Leu Ser Ser Glu Phe Lys Phe Thr Glu Asn Ile Lys Lys Ile 
                725                 730                 735     


Asn Ser Gly Phe Glu Asp Val Glu Lys Gln Phe Ser Tyr Asp Ser Leu 
            740                 745                 750         


Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gln 
        755                 760                 765             


Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gln Ala Pro Pro 
    770                 775                 780                 


Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Asp Pro Val 
785                 790                 795                 800 


Arg Thr Lys Thr Arg Leu Lys Ile Leu Gln Asp Leu Tyr Asn Asn Cys 
                805                 810                 815     


Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Lys Asp Leu Ser Gly 
            820                 825                 830         


Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser Asp Lys Leu Tyr 
        835                 840                 845             


Leu Tyr Tyr Thr Gln Leu Gly Lys Cys Met Tyr Cys Gly Lys Pro Ile 
    850                 855                 860                 


Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp Ile Asp His Ile 
865                 870                 875                 880 


Tyr Pro Gln Ser Lys Ile Lys Asp Asp Ser Ile Ser Asn Arg Val Leu 
                885                 890                 895     


Val Cys Ser Ser Cys Asn Lys Asn Lys Glu Asp Lys Tyr Pro Leu Lys 
            900                 905                 910         


Ala Glu Ile Gln Ser Lys Gln Arg Gly Phe Trp Asn Phe Leu Gln Arg 
        915                 920                 925             


Asn Asn Phe Ile Ser Leu Glu Lys Leu Asn Arg Leu Thr Arg Thr Ser 
    930                 935                 940                 


Pro Ile Ser Asp Asp Glu Thr Ala Lys Phe Ile Ala Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ala Thr Lys Val Ala Ala Lys Val Leu Glu Lys Met 
                965                 970                 975     


Phe Pro Glu Thr Lys Ile Val Tyr Ser Lys Ala Glu Thr Val Ser Met 
            980                 985                 990         


Phe Arg Asn Lys Phe Asp Ile Ile  Lys Cys Arg Glu Ile  Asn Asp Phe 
        995                 1000                 1005             


His His  Ala His Asp Ala Tyr  Leu Asn Ile Val Val  Gly Asn Val 
    1010                 1015                 1020             


Tyr Asn  Thr Lys Phe Thr Asn  Asn Pro Trp Asn Phe  Ile Lys Glu 
    1025                 1030                 1035             


Lys Arg  Asp Asn Pro Lys Ile  Ala Asp Thr Tyr Asn  Tyr Tyr Lys 
    1040                 1045                 1050             


Val Phe  Asp Tyr Asp Val Lys  Arg Asn Asn Ile Thr  Ala Trp Glu 
    1055                 1060                 1065             


Lys Gly  Lys Thr Ile Ile Thr  Val Lys Asp Met Leu  Lys Arg Asn 
    1070                 1075                 1080             


Thr Pro  Ile Tyr Thr Arg Gln  Ala Ala Cys Lys Lys  Gly Glu Leu 
    1085                 1090                 1095             


Phe Asn  Gln Thr Ile Met Lys  Lys Gly Leu Gly Gln  His Pro Leu 
    1100                 1105                 1110             


Lys Lys  Glu Gly Pro Leu Ser  Asn Ile Ser Lys Tyr  Gly Gly Tyr 
    1115                 1120                 1125             


Asn Lys  Val Ser Ala Ala Tyr  Tyr Thr Leu Ile Glu  Tyr Glu Glu 
    1130                 1135                 1140             


Lys Gly  Ser Lys Ile Arg Ser  Leu Glu Thr Ile Pro  Leu Tyr Leu 
    1145                 1150                 1155             


Val Lys  Asp Ile Gln Lys Asn  Lys Asp Gly Leu Lys  Ser Tyr Leu 
    1160                 1165                 1170             


Thr Asp  Gln Ile Gly Lys Lys  Glu Ile Lys Ile Leu  Ile Pro Lys 
    1175                 1180                 1185             


Ile Lys  Ile Asn Ser Leu Leu  Lys Ile Asn Gly Phe  Pro Cys His 
    1190                 1195                 1200             


Ile Thr  Gly Lys Met Gly Glu  Ala Phe Val Leu Arg  Pro Ala Val 
    1205                 1210                 1215             


Gln Phe  Cys Cys Ser Asn Asp  Glu Ala Leu Tyr Phe  Lys Lys Ile 
    1220                 1225                 1230             


Ile Arg  Phe Asn Glu Ile Arg  Lys Gln Arg Glu Lys  Met Gly Lys 
    1235                 1240                 1245             


Thr Ile  Ser Pro Tyr Glu Asp  Leu Ser Phe Arg Ser  Tyr Ile Lys 
    1250                 1255                 1260             


Asp Asn  Leu Cys Lys Lys Thr  Lys Ala Asp Glu Ile  Glu Glu Lys 
    1265                 1270                 1275             


Glu Phe  Tyr Asp Leu Leu Gln  Lys Lys Asn Leu Glu  Ile Tyr Asp 
    1280                 1285                 1290             


Met Leu  Leu Thr Lys His Lys  Asp Thr Ile Tyr Lys  Lys Arg Pro 
    1295                 1300                 1305             


Asn Ser  Ala Thr Ile Asp Ile  Leu Val Lys Gly Lys  Glu Lys Phe 
    1310                 1315                 1320             


Lys Ser  Leu Ile Ile Glu Asn  Gln Phe Glu Val Ile  Leu Glu Ile 
    1325                 1330                 1335             


Leu Lys  Leu Phe Ser Ala Thr  Arg Asn Val Ser Asp  Leu Gln His 
    1340                 1345                 1350             


Ile Gly  Gly Ser Lys Asn Ala  Gly Asn Ala Arg Val  Gly Asn Lys 
    1355                 1360                 1365             


Ile Ser  Ser Leu Asp Asn Cys  Ile Leu Ile Tyr Gln  Ser Ile Thr 
    1370                 1375                 1380             


Gly Ile  Phe Glu Lys Arg Ile  Asp Leu Leu Lys Ile  
    1385                 1390                 1395 


<210> 609
<211> 1062
<212> PRT
<213> Treponema sp.


<220>
<223> Treponema sp. JC4

<400> 609
Met Ile Met Lys Leu Glu Lys Trp Arg Leu Gly Leu Asp Leu Gly Thr 
1               5                   10                  15      


Asn Ser Ile Gly Trp Ser Val Phe Ser Leu Asp Lys Asp Asn Ser Val 
            20                  25                  30          


Gln Asp Leu Ile Asp Met Gly Val Arg Ile Phe Ser Asp Gly Arg Asp 
        35                  40                  45              


Pro Lys Thr Lys Glu Pro Leu Ala Val Ala Arg Arg Thr Ala Arg Ser 
    50                  55                  60                  


Gln Arg Lys Leu Ile Tyr Arg Arg Lys Leu Arg Arg Lys Gln Val Phe 
65                  70                  75                  80  


Lys Phe Leu Gln Glu Gln Gly Leu Phe Pro Lys Thr Lys Glu Glu Cys 
                85                  90                  95      


Met Thr Leu Lys Ser Leu Asn Pro Tyr Glu Leu Arg Ile Lys Ala Leu 
            100                 105                 110         


Asp Glu Lys Leu Glu Pro Tyr Glu Leu Gly Arg Ala Leu Phe Asn Leu 
        115                 120                 125             


Ala Val Arg Arg Gly Phe Lys Ser Asn Arg Lys Asp Gly Ser Arg Glu 
    130                 135                 140                 


Glu Val Ser Glu Lys Lys Ser Pro Asp Glu Ile Lys Thr Gln Ala Asp 
145                 150                 155                 160 


Met Gln Thr His Leu Glu Lys Ala Ile Lys Glu Asn Gly Cys Arg Thr 
                165                 170                 175     


Ile Thr Glu Phe Leu Tyr Lys Asn Gln Gly Glu Asn Gly Gly Ile Arg 
            180                 185                 190         


Phe Ala Pro Gly Arg Met Thr Tyr Tyr Pro Thr Arg Lys Met Tyr Glu 
        195                 200                 205             


Glu Glu Phe Asn Leu Ile Arg Ser Lys Gln Glu Lys Tyr Tyr Pro Gln 
    210                 215                 220                 


Val Asp Trp Asp Asp Ile Tyr Lys Ala Ile Phe Tyr Gln Arg Pro Leu 
225                 230                 235                 240 


Lys Pro Gln Gln Arg Gly Tyr Cys Ile Tyr Glu Asn Asp Lys Glu Arg 
                245                 250                 255     


Thr Phe Lys Ala Met Pro Cys Ser Gln Lys Leu Arg Ile Leu Gln Asp 
            260                 265                 270         


Ile Gly Asn Leu Ala Tyr Tyr Glu Gly Gly Ser Lys Lys Arg Val Glu 
        275                 280                 285             


Leu Asn Asp Asn Gln Asp Lys Val Leu Tyr Glu Leu Leu Asn Ser Lys 
    290                 295                 300                 


Asp Lys Val Thr Phe Asp Gln Met Arg Lys Ala Leu Cys Leu Ala Asp 
305                 310                 315                 320 


Ser Asn Ser Phe Asn Leu Glu Glu Asn Arg Asp Phe Leu Ile Gly Asn 
                325                 330                 335     


Pro Thr Ala Val Lys Met Arg Ser Lys Asn Arg Phe Gly Lys Leu Trp 
            340                 345                 350         


Asp Glu Ile Pro Leu Glu Glu Gln Asp Leu Ile Ile Glu Thr Ile Ile 
        355                 360                 365             


Thr Ala Asp Glu Asp Asp Ala Val Tyr Glu Val Ile Lys Lys Tyr Asp 
    370                 375                 380                 


Leu Thr Gln Glu Gln Arg Asp Phe Ile Val Lys Asn Thr Ile Leu Gln 
385                 390                 395                 400 


Ser Gly Thr Ser Met Leu Cys Lys Glu Val Ser Glu Lys Leu Val Lys 
                405                 410                 415     


Arg Leu Glu Glu Ile Ala Asp Leu Lys Tyr His Glu Ala Val Glu Ser 
            420                 425                 430         


Leu Gly Tyr Lys Phe Ala Asp Gln Thr Val Glu Lys Tyr Asp Leu Leu 
        435                 440                 445             


Pro Tyr Tyr Gly Lys Val Leu Pro Gly Ser Thr Met Glu Ile Asp Leu 
    450                 455                 460                 


Ser Ala Pro Glu Thr Asn Pro Glu Lys His Tyr Gly Lys Ile Ser Asn 
465                 470                 475                 480 


Pro Thr Val His Val Ala Leu Asn Gln Thr Arg Val Val Val Asn Ala 
                485                 490                 495     


Leu Ile Lys Glu Tyr Gly Lys Pro Ser Gln Ile Ala Ile Glu Leu Ser 
            500                 505                 510         


Arg Asp Leu Lys Asn Asn Val Glu Lys Lys Ala Glu Ile Ala Arg Lys 
        515                 520                 525             


Gln Asn Gln Arg Ala Lys Glu Asn Ile Ala Ile Asn Asp Thr Ile Ser 
    530                 535                 540                 


Ala Leu Tyr His Thr Ala Phe Pro Gly Lys Ser Phe Tyr Pro Asn Arg 
545                 550                 555                 560 


Asn Asp Arg Met Lys Tyr Arg Leu Trp Ser Glu Leu Gly Leu Gly Asn 
                565                 570                 575     


Lys Cys Ile Tyr Cys Gly Lys Gly Ile Ser Gly Ala Glu Leu Phe Thr 
            580                 585                 590         


Lys Glu Ile Glu Ile Glu His Ile Leu Pro Phe Ser Arg Thr Leu Leu 
        595                 600                 605             


Asp Ala Glu Ser Asn Leu Thr Val Ala His Ser Ser Cys Asn Ala Phe 
    610                 615                 620                 


Lys Ala Glu Arg Ser Pro Phe Glu Ala Phe Gly Thr Asn Pro Ser Gly 
625                 630                 635                 640 


Tyr Ser Trp Gln Glu Ile Ile Gln Arg Ala Asn Gln Leu Lys Asn Thr 
                645                 650                 655     


Ser Lys Lys Asn Lys Phe Ser Pro Asn Ala Met Asp Ser Phe Glu Lys 
            660                 665                 670         


Asp Ser Ser Phe Ile Ala Arg Gln Leu Ser Asp Asn Gln Tyr Ile Ala 
        675                 680                 685             


Lys Ala Ala Leu Arg Tyr Leu Lys Cys Leu Val Glu Asn Pro Ser Asp 
    690                 695                 700                 


Val Trp Thr Thr Asn Gly Ser Met Thr Lys Leu Leu Arg Asp Lys Trp 
705                 710                 715                 720 


Glu Met Asp Ser Ile Leu Cys Arg Lys Phe Thr Glu Lys Glu Val Ala 
                725                 730                 735     


Leu Leu Gly Leu Lys Pro Glu Gln Ile Gly Asn Tyr Lys Lys Asn Arg 
            740                 745                 750         


Phe Asp His Arg His His Ala Ile Asp Ala Val Val Ile Gly Leu Thr 
        755                 760                 765             


Asp Arg Ser Met Val Gln Lys Leu Ala Thr Lys Asn Ser His Lys Gly 
    770                 775                 780                 


Asn Arg Ile Glu Ile Pro Glu Phe Pro Ile Leu Arg Ser Asp Leu Ile 
785                 790                 795                 800 


Glu Lys Val Lys Asn Ile Val Val Ser Phe Lys Pro Asp His Gly Ala 
                805                 810                 815     


Glu Gly Lys Leu Ser Lys Glu Thr Leu Leu Gly Lys Ile Lys Leu His 
            820                 825                 830         


Gly Lys Glu Thr Phe Val Cys Arg Glu Asn Ile Val Ser Leu Ser Glu 
        835                 840                 845             


Lys Asn Leu Asp Asp Ile Val Asp Glu Lys Ile Lys Ser Lys Val Lys 
    850                 855                 860                 


Asp Tyr Val Ala Lys His Lys Gly Gln Lys Ile Glu Ala Val Leu Ser 
865                 870                 875                 880 


Asp Phe Ser Lys Glu Asn Gly Ile Lys Lys Val Arg Cys Val Asn Arg 
                885                 890                 895     


Val Gln Thr Pro Ile Glu Ile Thr Ser Gly Lys Ile Ser Arg Tyr Leu 
            900                 905                 910         


Ser Pro Glu Asp Tyr Phe Ala Ala Val Ile Trp Glu Ile Pro Gly Glu 
        915                 920                 925             


Lys Lys Thr Phe Lys Ala Gln Tyr Ile Arg Arg Asn Glu Val Glu Lys 
    930                 935                 940                 


Asn Ser Lys Gly Leu Asn Val Val Lys Pro Ala Val Leu Glu Asn Gly 
945                 950                 955                 960 


Lys Pro His Pro Ala Ala Lys Gln Val Cys Leu Leu His Lys Asp Asp 
                965                 970                 975     


Tyr Leu Glu Phe Ser Asp Lys Gly Lys Met Tyr Phe Cys Arg Ile Ala 
            980                 985                 990         


Gly Tyr Ala Ala Thr Asn Asn Lys  Leu Asp Ile Arg Pro  Val Tyr Ala 
        995                 1000                 1005             


Val Ser  Tyr Cys Ala Asp Trp  Ile Asn Ser Thr Asn  Glu Thr Met 
    1010                 1015                 1020             


Leu Thr  Gly Tyr Trp Lys Pro  Thr Pro Thr Gln Asn  Trp Val Ser 
    1025                 1030                 1035             


Val Asn  Val Leu Phe Asp Lys  Gln Lys Ala Arg Leu  Val Thr Val 
    1040                 1045                 1050             


Ser Pro  Ile Gly Arg Val Phe  Arg Lys 
    1055                 1060         


<210> 610
<211> 1011
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      uncultured delta proteobacterium HF0070_07E19 polypeptide

<400> 610
Met Ser Ser Lys Ala Ile Asp Ser Leu Glu Gln Leu Asp Leu Phe Lys 
1               5                   10                  15      


Pro Gln Glu Tyr Thr Leu Gly Leu Asp Leu Gly Ile Lys Ser Ile Gly 
            20                  25                  30          


Trp Ala Ile Leu Ser Gly Glu Arg Ile Ala Asn Ala Gly Val Tyr Leu 
        35                  40                  45              


Phe Glu Thr Ala Glu Glu Leu Asn Ser Thr Gly Asn Lys Leu Ile Ser 
    50                  55                  60                  


Lys Ala Ala Glu Arg Gly Arg Lys Arg Arg Ile Arg Arg Met Leu Asp 
65                  70                  75                  80  


Arg Lys Ala Arg Arg Gly Arg His Ile Arg Tyr Leu Leu Glu Arg Glu 
                85                  90                  95      


Gly Leu Pro Thr Asp Glu Leu Glu Glu Val Val Val His Gln Ser Asn 
            100                 105                 110         


Arg Thr Leu Trp Asp Val Arg Ala Glu Ala Val Glu Arg Lys Leu Thr 
        115                 120                 125             


Lys Gln Glu Leu Ala Ala Val Leu Phe His Leu Val Arg His Arg Gly 
    130                 135                 140                 


Tyr Phe Pro Asn Thr Lys Lys Leu Pro Pro Asp Asp Glu Ser Asp Ser 
145                 150                 155                 160 


Ala Asp Glu Glu Gln Gly Lys Ile Asn Arg Ala Thr Ser Arg Leu Arg 
                165                 170                 175     


Glu Glu Leu Lys Ala Ser Asp Cys Lys Thr Ile Gly Gln Phe Leu Ala 
            180                 185                 190         


Gln Asn Arg Asp Arg Gln Arg Asn Arg Glu Gly Asp Tyr Ser Asn Leu 
        195                 200                 205             


Met Ala Arg Lys Leu Val Phe Glu Glu Ala Leu Gln Ile Leu Ala Phe 
    210                 215                 220                 


Gln Arg Lys Gln Gly His Glu Leu Ser Lys Asp Phe Glu Lys Thr Tyr 
225                 230                 235                 240 


Leu Asp Val Leu Met Gly Gln Arg Ser Gly Arg Ser Pro Lys Leu Gly 
                245                 250                 255     


Asn Cys Ser Leu Ile Pro Ser Glu Leu Arg Ala Pro Ser Ser Ala Pro 
            260                 265                 270         


Ser Thr Glu Trp Phe Lys Phe Leu Gln Asn Leu Gly Asn Leu Gln Ile 
        275                 280                 285             


Ser Asn Ala Tyr Arg Glu Glu Trp Ser Ile Asp Ala Pro Arg Arg Ala 
    290                 295                 300                 


Gln Ile Ile Asp Ala Cys Ser Gln Arg Ser Thr Ser Ser Tyr Trp Gln 
305                 310                 315                 320 


Ile Arg Arg Asp Phe Gln Ile Pro Asp Glu Tyr Arg Phe Asn Leu Val 
                325                 330                 335     


Asn Tyr Glu Arg Arg Asp Pro Asp Val Asp Leu Gln Glu Tyr Leu Gln 
            340                 345                 350         


Gln Gln Glu Arg Lys Thr Leu Ala Asn Phe Arg Asn Trp Lys Gln Leu 
        355                 360                 365             


Glu Lys Ile Ile Gly Thr Gly His Pro Ile Gln Thr Leu Asp Glu Ala 
    370                 375                 380                 


Ala Arg Leu Ile Thr Leu Ile Lys Asp Asp Glu Lys Leu Ser Asp Gln 
385                 390                 395                 400 


Leu Ala Asp Leu Leu Pro Glu Ala Ser Asp Lys Ala Ile Thr Gln Leu 
                405                 410                 415     


Cys Glu Leu Asp Phe Thr Thr Ala Ala Lys Ile Ser Leu Glu Ala Met 
            420                 425                 430         


Tyr Arg Ile Leu Pro His Met Asn Gln Gly Met Gly Phe Phe Asp Ala 
        435                 440                 445             


Cys Gln Gln Glu Ser Leu Pro Glu Ile Gly Val Pro Pro Ala Gly Asp 
    450                 455                 460                 


Arg Val Pro Pro Phe Asp Glu Met Tyr Asn Pro Val Val Asn Arg Val 
465                 470                 475                 480 


Leu Ser Gln Ser Arg Lys Leu Ile Asn Ala Val Ile Asp Glu Tyr Gly 
                485                 490                 495     


Met Pro Ala Lys Ile Arg Val Glu Leu Ala Arg Asp Leu Gly Lys Gly 
            500                 505                 510         


Arg Glu Leu Arg Glu Arg Ile Lys Leu Asp Gln Leu Asp Lys Ser Lys 
        515                 520                 525             


Gln Asn Asp Gln Arg Ala Glu Asp Phe Arg Ala Glu Phe Gln Gln Ala 
    530                 535                 540                 


Pro Arg Gly Asp Gln Ser Leu Arg Tyr Arg Leu Trp Lys Glu Gln Asn 
545                 550                 555                 560 


Cys Thr Cys Pro Tyr Ser Gly Arg Met Ile Pro Val Asn Ser Val Leu 
                565                 570                 575     


Ser Glu Asp Thr Gln Ile Asp His Ile Leu Pro Ile Ser Gln Ser Phe 
            580                 585                 590         


Asp Asn Ser Leu Ser Asn Lys Val Leu Cys Phe Thr Glu Glu Asn Ala 
        595                 600                 605             


Gln Lys Ser Asn Arg Thr Pro Phe Glu Tyr Leu Asp Ala Ala Asp Phe 
    610                 615                 620                 


Gln Arg Leu Glu Ala Ile Ser Gly Asn Trp Pro Glu Ala Lys Arg Asn 
625                 630                 635                 640 


Lys Leu Leu His Lys Ser Phe Gly Lys Val Ala Glu Glu Trp Lys Ser 
                645                 650                 655     


Arg Ala Leu Asn Asp Thr Arg Tyr Leu Thr Ser Ala Leu Ala Asp His 
            660                 665                 670         


Leu Arg His His Leu Pro Asp Ser Lys Ile Gln Thr Val Asn Gly Arg 
        675                 680                 685             


Ile Thr Gly Tyr Leu Arg Lys Gln Trp Gly Leu Glu Lys Asp Arg Asp 
    690                 695                 700                 


Lys His Thr His His Ala Val Asp Ala Ile Val Val Ala Cys Thr Thr 
705                 710                 715                 720 


Pro Ala Ile Val Gln Gln Val Thr Leu Tyr His Gln Asp Ile Arg Arg 
                725                 730                 735     


Tyr Lys Lys Leu Gly Glu Lys Arg Pro Thr Pro Trp Pro Glu Thr Phe 
            740                 745                 750         


Arg Gln Asp Val Leu Asp Val Glu Glu Glu Ile Phe Ile Thr Arg Gln 
        755                 760                 765             


Pro Lys Lys Val Ser Gly Gly Ile Gln Thr Lys Asp Thr Leu Arg Lys 
    770                 775                 780                 


His Arg Ser Lys Pro Asp Arg Gln Arg Val Ala Leu Thr Lys Val Lys 
785                 790                 795                 800 


Leu Ala Asp Leu Glu Arg Leu Val Glu Lys Asp Ala Ser Asn Arg Asn 
                805                 810                 815     


Leu Tyr Glu His Leu Lys Gln Cys Leu Glu Glu Ser Gly Asp Gln Pro 
            820                 825                 830         


Thr Lys Ala Phe Lys Ala Pro Phe Tyr Met Pro Ser Gly Pro Glu Ala 
        835                 840                 845             


Lys Gln Arg Pro Ile Leu Ser Lys Val Thr Leu Leu Arg Glu Lys Pro 
    850                 855                 860                 


Glu Pro Pro Lys Gln Leu Thr Glu Leu Ser Gly Gly Arg Arg Tyr Asp 
865                 870                 875                 880 


Ser Met Ala Gln Gly Arg Leu Asp Ile Tyr Arg Tyr Lys Pro Gly Gly 
                885                 890                 895     


Lys Arg Lys Asp Glu Tyr Arg Val Val Leu Gln Arg Met Ile Asp Leu 
            900                 905                 910         


Met Arg Gly Glu Glu Asn Val His Val Phe Gln Lys Gly Val Pro Tyr 
        915                 920                 925             


Asp Gln Gly Pro Glu Ile Glu Gln Asn Tyr Thr Phe Leu Phe Ser Leu 
    930                 935                 940                 


Tyr Phe Asp Asp Leu Val Glu Phe Gln Arg Ser Ala Asp Ser Glu Val 
945                 950                 955                 960 


Ile Arg Gly Tyr Tyr Arg Thr Phe Asn Ile Ala Asn Gly Gln Leu Lys 
                965                 970                 975     


Ile Ser Thr Tyr Leu Glu Gly Arg Gln Asp Phe Asp Phe Phe Gly Ala 
            980                 985                 990         


Asn Arg Leu Ala His Phe Ala Lys  Val Gln Val Asn Leu  Leu Gly Lys 
        995                 1000                 1005             


Val Ile  Lys 
    1010     


<210> 611
<211> 1032
<212> PRT
<213> Unknown


<220>
<223> Description of Unknown:
      uncultured Termite group 1 bacterium phylotype Rs-D17
      polypeptide

<400> 611
Met Leu Tyr His Ile Ala Asn His Arg Gly Thr Asp Ser Val Arg Ser 
1               5                   10                  15      


Phe Leu Glu Tyr Asp Asp Asp Lys Ile Lys Glu Asn Thr Leu Thr Ala 
            20                  25                  30          


Lys Ile Ala Lys Glu Thr Lys Lys Val Ile Asp Ala Lys Lys Tyr Arg 
        35                  40                  45              


Thr Phe Gly Glu Tyr Leu Tyr Lys Gly Lys Ile Glu Lys Phe Gln Gln 
    50                  55                  60                  


Asn Ile Arg Lys Lys Val Ser Asn Arg Lys Thr Pro Ala Asn Lys Asn 
65                  70                  75                  80  


Lys Glu Phe Ala Val Thr Arg Asp Val Ile Ile Lys Glu Thr Glu Lys 
                85                  90                  95      


Ile Leu Ala Ser Gln Lys Gln Tyr Tyr Thr Tyr Ile Leu Thr Asp Glu 
            100                 105                 110         


Tyr Ile Lys Lys Ile Lys Asp Ala Ile Ser Tyr Gln Thr Glu Lys Leu 
        115                 120                 125             


Ile Pro Glu Ser Gly Tyr Cys Pro Tyr Phe Lys Asp Glu Lys Arg Leu 
    130                 135                 140                 


Pro Arg Ser His Lys Leu Asn Glu Tyr Arg Arg Met Tyr Glu Ala Leu 
145                 150                 155                 160 


Asn Asn Ala Lys Tyr Phe Asp Pro Val Leu Asp Glu Asn Thr Gly Glu 
                165                 170                 175     


Ile Leu Ser Tyr Gln Glu Lys Glu Phe Ser Arg Glu Glu Lys Lys Ile 
            180                 185                 190         


Leu Phe Asp Glu Val Leu Leu Lys Gly Met Glu Leu Thr Glu Ser Gly 
        195                 200                 205             


Ala Lys Lys Leu Leu Tyr His Leu Pro Asp Gly Cys Glu Val Gln Leu 
    210                 215                 220                 


Gln Gly Arg Asp Lys Thr Thr Gln Lys Ile Lys Gly Tyr Ala Leu Val 
225                 230                 235                 240 


Asp Leu Glu Ala Ser Pro Phe Trp Leu Arg Leu Ser Gln Gln Gln Gln 
                245                 250                 255     


Asp Glu Phe Leu Tyr Asp Trp Asn Ser Leu Pro Leu Glu Lys Leu Lys 
            260                 265                 270         


Pro Lys Leu Thr Asn Tyr Tyr Ser Leu Thr Glu Ser Glu Val Asp Glu 
        275                 280                 285             


Thr Phe Gln Glu Ile Lys Leu Pro Ser Asn Tyr Ala Ser Val Gly Lys 
    290                 295                 300                 


Lys Ala Met Glu Ile Leu Leu Thr Tyr Ile Lys Asp Gly Cys Ser Tyr 
305                 310                 315                 320 


Thr Glu Ala Leu Glu Lys Ala Val Ser Glu Gly Lys Leu Lys Val Asp 
                325                 330                 335     


Lys Gln Thr Met Ile Tyr Asp Ser Leu Pro Tyr Tyr Gly Lys Ile Leu 
            340                 345                 350         


Lys Glu Ser Thr Gln Lys Leu Ile Gly Lys Ala Phe Ser Lys Gln Phe 
        355                 360                 365             


Ala Asp Arg Asn Tyr Lys Glu Pro Asp Thr Asn Lys Asn Glu Arg Glu 
    370                 375                 380                 


Phe Gly Lys Ile Ala Asn Pro Val Val His Gln Thr Leu Asn Glu Leu 
385                 390                 395                 400 


Arg Lys Leu Ile Asn Glu Ile Ile Thr Val Phe Gly Lys Lys Pro Leu 
                405                 410                 415     


Glu Ile Gly Leu Glu Thr Thr Arg Glu Leu Lys Lys Ser Lys Lys Asn 
            420                 425                 430         


Arg Glu Tyr Leu Ser Lys Gln Gln Asn Lys Asn Glu Tyr Ala Arg Asn 
        435                 440                 445             


Arg Ile Tyr Lys Glu Tyr Ile Glu Pro His Leu Ser Gln Ile Lys Ser 
    450                 455                 460                 


Arg Gln Glu Asn Pro Ser Lys Tyr Ile Ser Lys Phe Glu Leu Leu Glu 
465                 470                 475                 480 


Glu Gln Asn Phe Ile Cys Pro Phe Cys Ser Glu Lys Ile Thr Pro Asp 
                485                 490                 495     


Asp Ile Ile Asn Ser Lys Val Asp Val Glu His Ile Phe Pro Ile Glu 
            500                 505                 510         


Glu Ser Glu Asp Ile Thr Lys Asn Asn Leu Val Ile Ala His Asn Glu 
        515                 520                 525             


Cys Asn Ala Asp Lys Gly Lys Lys Ser Pro Phe Asp Ala Phe Gly Asp 
    530                 535                 540                 


Lys Thr Ser Gly Lys Tyr Arg Trp Asn Cys Ile Leu His Asn Ala Gln 
545                 550                 555                 560 


Lys Asn Leu Pro His Lys Val Trp Arg Phe Tyr Gln Gly Ser Leu Glu 
                565                 570                 575     


Lys Phe Leu Glu Asn Lys Pro Met Ser Arg Arg Phe Gly Thr Asp Asn 
            580                 585                 590         


Ser Tyr Ile Ser Lys Ile Ala Ala Arg Tyr Leu Ala Cys Leu Phe Asn 
        595                 600                 605             


Asp Pro Tyr His Ser Glu Ile Phe Cys Ile Lys Ser Ser Leu Ile Ala 
    610                 615                 620                 


Gln Leu Arg Ile Ala Trp Asp Leu Asn Ser Ile Met Val Pro Leu Val 
625                 630                 635                 640 


Lys Asn Ile Leu Ser Glu Lys Glu Leu Glu Glu Phe Lys Ile Ser Lys 
                645                 650                 655     


Asn Lys Lys Ile Arg Ile Asp Asn Arg His His Ala Leu Asp Ala Ile 
            660                 665                 670         


Val Ile Ala Tyr Ala Asn Arg Gly Tyr His Asn Phe Leu Asn Arg Ile 
        675                 680                 685             


His Ala Lys Glu Tyr Lys Ile Asn Tyr Arg Glu Lys Ser Trp Leu Ser 
    690                 695                 700                 


Lys Ile Leu Leu Pro Pro Leu Asn Arg Asp Leu Glu Asp Phe Lys Ile 
705                 710                 715                 720 


Ser Val Lys Asp Ser Ile Glu Lys Ala Asn Val Ser Ile Lys His Asp 
                725                 730                 735     


His Asn Thr Asn Gly Ser Leu Val Lys Ala Thr Ala Tyr Lys Val Tyr 
            740                 745                 750         


Tyr Ser Gly Ala Gly Glu Tyr Ile Ile Thr Thr Ser Lys Asn Val Glu 
        755                 760                 765             


Glu Ile Ser Phe Lys Glu Lys Glu Asp Pro Lys Asp Thr Leu Tyr Arg 
    770                 775                 780                 


Ala Leu Cys Lys Phe Glu Cys Arg Asp Ile Asp Ile Lys Asp Glu Lys 
785                 790                 795                 800 


Leu Ile Lys Lys Leu Lys Tyr Asn Ser Thr Leu Tyr Lys Lys Val Gln 
                805                 810                 815     


Asn Asn Leu Ser Lys Ala Lys Gln Glu Leu Glu Gln Asp Asn Lys Lys 
            820                 825                 830         


Thr Glu Glu Glu Gly Lys Lys Ser Gln Lys Ile Thr Glu Val Arg Ile 
        835                 840                 845             


Tyr Lys Lys Ala Cys Ser Leu Val Lys Gly Gln Tyr Ile Gln Cys Gly 
    850                 855                 860                 


Ser Arg Leu Lys Asp Lys Phe Phe Ala Val Lys Glu Pro Thr Glu Ile 
865                 870                 875                 880 


Lys Thr Gly Leu Gly Tyr Asp Thr Gly Asp Asn Leu Phe Leu Asp Leu 
                885                 890                 895     


Tyr Tyr Asp Lys Thr Gly Lys Leu Cys Gly Glu Ile Ile Arg Lys Val 
            900                 905                 910         


Asn Phe Asn Arg Asn Lys Pro Asn Tyr Gln Lys Glu Gly Tyr Thr Leu 
        915                 920                 925             


Phe Glu Arg Ile Tyr Gln Ser Asp Ile Leu Glu Val Asp Thr Ser Glu 
    930                 935                 940                 


Asp Arg Ile Ser Leu Lys Asn Lys Thr Gly Ser Ala Pro Ser Asp Arg 
945                 950                 955                 960 


Thr Phe Ile Lys Val Asn Thr Phe Thr Glu Val Asn Ala Tyr Phe Asp 
                965                 970                 975     


Gly Lys Arg Asp Lys Ile Gln Ile Phe Phe Gly Asn Leu Leu Lys Ser 
            980                 985                 990         


Ser Phe Lys Asn Asp Ser Phe Phe  Ile Ser Ser Met Gln  Lys Tyr Asn 
        995                 1000                 1005             


Val Arg  Lys Val Ile Leu Thr  Ser Leu Gly Ile Ile  Lys Tyr Arg 
    1010                 1015                 1020             


Ser Gln  Ile Leu Lys Asn Lys  Glu Val 
    1025                 1030         


<210> 612
<211> 1398
<212> PRT
<213> Veillonella atypica


<220>
<223> Veillonella atypica ACS-134-V-Col7a

<400> 612
Met Glu Thr Gln Thr Ser Asn Gln Leu Ile Thr Ser His Leu Lys Asp 
1               5                   10                  15      


Tyr Pro Lys Gln Asp Tyr Phe Val Gly Leu Asp Ile Gly Thr Asn Ser 
            20                  25                  30          


Val Gly Trp Ala Val Thr Asn Thr Ser Tyr Glu Leu Leu Lys Phe His 
        35                  40                  45              


Ser His Lys Met Trp Gly Ser Arg Leu Phe Glu Glu Gly Glu Ser Ala 
    50                  55                  60                  


Val Thr Arg Arg Gly Phe Arg Ser Met Arg Arg Arg Leu Glu Arg Arg 
65                  70                  75                  80  


Lys Leu Arg Leu Lys Leu Leu Glu Glu Leu Phe Ala Asp Ala Met Ala 
                85                  90                  95      


Gln Val Asp Ser Thr Phe Phe Ile Arg Leu His Glu Ser Lys Tyr His 
            100                 105                 110         


Tyr Glu Asp Lys Thr Thr Gly His Ser Ser Lys His Ile Leu Phe Ile 
        115                 120                 125             


Asp Glu Asp Tyr Thr Asp Gln Asp Tyr Phe Thr Glu Tyr Pro Thr Ile 
    130                 135                 140                 


Tyr His Leu Arg Lys Asp Leu Met Glu Asn Gly Thr Asp Asp Ile Arg 
145                 150                 155                 160 


Lys Leu Phe Leu Ala Val His His Ile Leu Lys Tyr Arg Gly Asn Phe 
                165                 170                 175     


Leu Tyr Glu Gly Ala Thr Phe Asn Ser Asn Ala Phe Thr Phe Glu Asp 
            180                 185                 190         


Val Leu Lys Gln Ala Leu Val Asn Ile Thr Phe Asn Cys Phe Asp Thr 
        195                 200                 205             


Asn Ser Ala Ile Ser Ser Ile Ser Asn Ile Leu Met Glu Ser Gly Lys 
    210                 215                 220                 


Thr Lys Ser Asp Lys Ala Lys Ala Ile Glu Arg Leu Val Asp Thr Tyr 
225                 230                 235                 240 


Thr Val Phe Asp Glu Val Asn Thr Pro Asp Lys Pro Gln Lys Glu Gln 
                245                 250                 255     


Val Lys Glu Asp Lys Lys Thr Leu Lys Ala Phe Ala Asn Leu Val Leu 
            260                 265                 270         


Gly Leu Ser Ala Asn Leu Ile Asp Leu Phe Gly Ser Val Glu Asp Ile 
        275                 280                 285             


Asp Asp Asp Leu Lys Lys Leu Gln Ile Val Gly Asp Thr Tyr Asp Glu 
    290                 295                 300                 


Lys Arg Asp Glu Leu Ala Lys Val Trp Gly Asp Glu Ile His Ile Ile 
305                 310                 315                 320 


Asp Asp Cys Lys Ser Val Tyr Asp Ala Ile Ile Leu Met Ser Ile Lys 
                325                 330                 335     


Glu Pro Gly Leu Thr Ile Ser Gln Ser Lys Val Lys Ala Phe Asp Lys 
            340                 345                 350         


His Lys Glu Asp Leu Val Ile Leu Lys Ser Leu Leu Lys Leu Asp Arg 
        355                 360                 365             


Asn Val Tyr Asn Glu Met Phe Lys Ser Asp Lys Lys Gly Leu His Asn 
    370                 375                 380                 


Tyr Val His Tyr Ile Lys Gln Gly Arg Thr Glu Glu Thr Ser Cys Ser 
385                 390                 395                 400 


Arg Glu Asp Phe Tyr Lys Tyr Thr Lys Lys Ile Val Glu Gly Leu Ala 
                405                 410                 415     


Asp Ser Lys Asp Lys Glu Tyr Ile Leu Asn Glu Ile Glu Leu Gln Thr 
            420                 425                 430         


Leu Leu Pro Leu Gln Arg Ile Lys Asp Asn Gly Val Ile Pro Tyr Gln 
        435                 440                 445             


Leu His Leu Glu Glu Leu Lys Val Ile Leu Asp Lys Cys Gly Pro Lys 
    450                 455                 460                 


Phe Pro Phe Leu His Thr Val Ser Asp Gly Phe Ser Val Thr Glu Lys 
465                 470                 475                 480 


Leu Ile Lys Met Leu Glu Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
                485                 490                 495     


Asn Thr His His Asn Ile Asp Asn Gly Gly Phe Ser Trp Ala Val Arg 
            500                 505                 510         


Lys Gln Ala Gly Arg Val Thr Pro Trp Asn Phe Glu Glu Lys Ile Asp 
        515                 520                 525             


Arg Glu Lys Ser Ala Ala Ala Phe Ile Lys Asn Leu Thr Asn Lys Cys 
    530                 535                 540                 


Thr Tyr Leu Phe Gly Glu Asp Val Leu Pro Lys Ser Ser Leu Leu Tyr 
545                 550                 555                 560 


Ser Glu Phe Met Leu Leu Asn Glu Leu Asn Asn Val Arg Ile Asp Gly 
                565                 570                 575     


Lys Ala Leu Ala Gln Gly Val Lys Gln His Leu Ile Asp Ser Ile Phe 
            580                 585                 590         


Lys Gln Asp His Lys Lys Met Thr Lys Asn Arg Ile Glu Leu Phe Leu 
        595                 600                 605             


Lys Asp Asn Asn Tyr Ile Thr Lys Lys His Lys Pro Glu Ile Thr Gly 
    610                 615                 620                 


Leu Asp Gly Glu Ile Lys Asn Asp Leu Thr Ser Tyr Arg Asp Met Val 
625                 630                 635                 640 


Arg Ile Leu Gly Asn Asn Phe Asp Val Ser Met Ala Glu Asp Ile Ile 
                645                 650                 655     


Thr Asp Ile Thr Ile Phe Gly Glu Ser Lys Lys Met Leu Arg Gln Thr 
            660                 665                 670         


Leu Arg Asn Lys Phe Gly Ser Gln Leu Asn Asp Glu Thr Ile Lys Lys 
        675                 680                 685             


Leu Ser Lys Leu Arg Tyr Arg Asp Trp Gly Arg Leu Ser Lys Lys Leu 
    690                 695                 700                 


Leu Lys Gly Ile Asp Gly Cys Asp Lys Ala Gly Asn Gly Ala Pro Lys 
705                 710                 715                 720 


Thr Ile Ile Glu Leu Met Arg Asn Asp Ser Tyr Asn Leu Met Glu Ile 
                725                 730                 735     


Leu Gly Asp Lys Phe Ser Phe Met Glu Cys Ile Glu Glu Glu Asn Ala 
            740                 745                 750         


Lys Leu Ala Gln Gly Gln Val Val Asn Pro His Asp Ile Ile Asp Glu 
        755                 760                 765             


Leu Ala Leu Ser Pro Ala Val Lys Arg Ala Val Trp Gln Ala Leu Arg 
    770                 775                 780                 


Ile Val Asp Glu Val Ala His Ile Lys Lys Ala Leu Pro Ser Arg Ile 
785                 790                 795                 800 


Phe Val Glu Val Ala Arg Thr Asn Lys Ser Glu Lys Lys Lys Lys Asp 
                805                 810                 815     


Ser Arg Gln Lys Arg Leu Ser Asp Leu Tyr Ser Ala Ile Lys Lys Asp 
            820                 825                 830         


Asp Val Leu Gln Ser Gly Leu Gln Asp Lys Glu Phe Gly Ala Leu Lys 
        835                 840                 845             


Ser Gly Leu Ala Asn Tyr Asp Asp Ala Ala Leu Arg Ser Lys Lys Leu 
    850                 855                 860                 


Tyr Leu Tyr Tyr Thr Gln Met Gly Arg Cys Ala Tyr Thr Gly Asn Ile 
865                 870                 875                 880 


Ile Asp Leu Asn Gln Leu Asn Thr Asp Asn Tyr Asp Ile Asp His Ile 
                885                 890                 895     


Tyr Pro Arg Ser Leu Thr Lys Asp Asp Ser Phe Asp Asn Leu Val Leu 
            900                 905                 910         


Cys Glu Arg Thr Ala Asn Ala Lys Lys Ser Asp Ile Tyr Pro Ile Asp 
        915                 920                 925             


Asn Arg Ile Gln Thr Lys Gln Lys Pro Phe Trp Ala Phe Leu Lys His 
    930                 935                 940                 


Gln Gly Leu Ile Ser Glu Arg Lys Tyr Glu Arg Leu Thr Arg Ile Ala 
945                 950                 955                 960 


Pro Leu Thr Ala Asp Asp Leu Ser Gly Phe Ile Ala Arg Gln Leu Val 
                965                 970                 975     


Glu Thr Asn Gln Ser Val Lys Ala Thr Thr Thr Leu Leu Arg Arg Leu 
            980                 985                 990         


Tyr Pro Asp Ile Asp Val Val Phe  Val Lys Ala Glu Asn  Val Ser Asp 
        995                 1000                 1005             


Phe Arg  His Asn Asn Asn Phe  Ile Lys Val Arg Ser  Leu Asn His 
    1010                 1015                 1020             


His His  His Ala Lys Asp Ala  Tyr Leu Asn Ile Val  Val Gly Asn 
    1025                 1030                 1035             


Val Tyr  His Glu Lys Phe Thr  Arg Asn Phe Arg Leu  Phe Phe Lys 
    1040                 1045                 1050             


Lys Asn  Gly Ala Asn Arg Thr  Tyr Asn Leu Ala Lys  Met Phe Asn 
    1055                 1060                 1065             


Tyr Asp  Val Ile Cys Thr Asn  Ala Gln Asp Gly Lys  Ala Trp Asp 
    1070                 1075                 1080             


Val Lys  Thr Ser Met Asn Thr  Val Lys Lys Met Met  Ala Ser Asn 
    1085                 1090                 1095             


Asp Val  Arg Val Thr Arg Arg  Leu Leu Glu Gln Ser  Gly Ala Leu 
    1100                 1105                 1110             


Ala Asp  Ala Thr Ile Tyr Lys  Ala Ser Val Ala Ala  Lys Ala Lys 
    1115                 1120                 1125             


Asp Gly  Ala Tyr Ile Gly Met  Lys Thr Lys Tyr Ser  Val Phe Ala 
    1130                 1135                 1140             


Asp Val  Thr Lys Tyr Gly Gly  Met Thr Lys Ile Lys  Asn Ala Tyr 
    1145                 1150                 1155             


Ser Ile  Ile Val Gln Tyr Thr  Gly Lys Lys Gly Glu  Glu Ile Lys 
    1160                 1165                 1170             


Glu Ile  Val Pro Leu Pro Ile  Tyr Leu Ile Asn Arg  Asn Ala Thr 
    1175                 1180                 1185             


Asp Ile  Glu Leu Ile Asp Tyr  Val Lys Ser Val Ile  Pro Lys Ala 
    1190                 1195                 1200             


Lys Asp  Ile Ser Ile Lys Tyr  Arg Lys Leu Cys Ile  Asn Gln Leu 
    1205                 1210                 1215             


Val Lys  Val Asn Gly Phe Tyr  Tyr Tyr Leu Gly Gly  Lys Thr Asn 
    1220                 1225                 1230             


Asp Lys  Ile Tyr Ile Asp Asn  Ala Ile Glu Leu Val  Val Pro His 
    1235                 1240                 1245             


Asp Ile  Ala Thr Tyr Ile Lys  Leu Leu Asp Lys Tyr  Asp Leu Leu 
    1250                 1255                 1260             


Arg Lys  Glu Asn Lys Thr Leu  Lys Ala Ser Ser Ile  Thr Thr Ser 
    1265                 1270                 1275             


Ile Tyr  Asn Ile Asn Thr Ser  Thr Val Val Ser Leu  Ser Asn Lys 
    1280                 1285                 1290             


Val Gly  Ile Asp Val Phe Asp  Tyr Phe Met Ser Lys  Leu Arg Thr 
    1295                 1300                 1305             


Pro Leu  Tyr Met Lys Met Lys  Gly Asn Lys Val Asp  Glu Leu Ser 
    1310                 1315                 1320             


Ser Thr  Gly Arg Ser Lys Phe  Ile Lys Met Thr Leu  Glu Glu Gln 
    1325                 1330                 1335             


Ser Ile  Tyr Leu Leu Glu Val  Leu Asn Leu Leu Thr  Asn Ser Lys 
    1340                 1345                 1350             


Thr Thr  Phe Asp Val Lys Pro  Leu Gly Ile Thr Gly  Ser Arg Ser 
    1355                 1360                 1365             


Thr Ile  Gly Val Lys Ile His  Asn Leu Asp Glu Phe  Lys Ile Ile 
    1370                 1375                 1380             


Asn Glu  Ser Ile Thr Gly Leu  Tyr Ser Asn Glu Val  Thr Ile Val 
    1385                 1390                 1395             


<210> 613
<211> 1398
<212> PRT
<213> Veillonella parvula


<220>
<223> Veillonella parvula ATCC 17745

<400> 613
Met Glu Thr Gln Ala Ser Asn Gln Leu Ile Ser Ser His Leu Lys Gly 
1               5                   10                  15      


Tyr Pro Ile Lys Asp Tyr Phe Val Gly Leu Asp Ile Gly Thr Ser Ser 
            20                  25                  30          


Val Gly Trp Ala Val Thr Asn Lys Ala Tyr Glu Leu Leu Lys Phe Arg 
        35                  40                  45              


Ser His Lys Met Trp Gly Ser Arg Leu Phe Asp Glu Gly Glu Ser Ala 
    50                  55                  60                  


Val Ala Arg Arg Gly Phe Arg Ser Met Arg Arg Arg Leu Glu Arg Arg 
65                  70                  75                  80  


Lys Leu Arg Leu Lys Leu Leu Glu Glu Leu Phe Ala Asp Ala Met Ala 
                85                  90                  95      


Gln Val Asp Pro Thr Phe Phe Met Arg Leu Arg Glu Ser Lys Tyr His 
            100                 105                 110         


Tyr Glu Asp Lys Thr Thr Gly His Ser Ser Lys His Ile Leu Phe Ile 
        115                 120                 125             


Asp Lys Asn Tyr Asn Asp Gln Asp Tyr Phe Lys Glu Tyr Pro Thr Val 
    130                 135                 140                 


Tyr His Leu Arg Ser Glu Leu Met Lys Ser Gly Thr Asp Asp Ile Arg 
145                 150                 155                 160 


Lys Leu Phe Leu Ala Val His His Ile Leu Lys Tyr Arg Gly Asn Phe 
                165                 170                 175     


Leu Tyr Glu Gly Ala Thr Phe Asp Ser Asn Ala Ser Thr Leu Asp Asp 
            180                 185                 190         


Val Ile Lys Gln Ala Leu Glu Asn Ile Thr Phe Asn Cys Phe Asp Cys 
        195                 200                 205             


Asn Ser Ala Ile Ser Ser Ile Gly Gln Ile Leu Met Glu Ala Gly Lys 
    210                 215                 220                 


Thr Lys Ser Asp Lys Ala Lys Ala Ile Glu His Leu Val Asp Thr Tyr 
225                 230                 235                 240 


Ile Ala Thr Asp Thr Val Asp Thr Ser Ser Lys Thr Gln Lys Asp Gln 
                245                 250                 255     


Val Lys Glu Asp Lys Lys Arg Leu Lys Ala Phe Ala Asn Leu Val Leu 
            260                 265                 270         


Gly Leu Asn Ala Ser Leu Ile Asp Leu Phe Gly Ser Val Glu Glu Leu 
        275                 280                 285             


Glu Glu Asp Leu Lys Lys Leu Gln Ile Thr Gly Asp Thr Tyr Asp Asp 
    290                 295                 300                 


Lys Arg Asp Glu Leu Ala Lys Ala Trp Ser Asp Glu Ile Tyr Ile Ile 
305                 310                 315                 320 


Asp Asp Cys Lys Ser Val Tyr Asp Ala Ile Ile Leu Leu Ser Ile Lys 
                325                 330                 335     


Glu Pro Gly Leu Thr Ile Ser Glu Ser Lys Val Lys Ala Phe Asn Lys 
            340                 345                 350         


His Lys Asp Asp Leu Ala Ile Leu Lys Ser Leu Leu Lys Ser Asp Arg 
        355                 360                 365             


Ser Ile Tyr Asn Thr Met Phe Lys Val Asp Glu Lys Gly Leu His Asn 
    370                 375                 380                 


Tyr Val His Tyr Ile Lys Gln Gly Arg Thr Glu Glu Thr Ser Cys Asn 
385                 390                 395                 400 


Arg Glu Asp Phe Tyr Lys Tyr Thr Lys Lys Ile Val Glu Gly Leu Ser 
                405                 410                 415     


Asp Ser Lys Asp Lys Glu Tyr Ile Leu Ser Gln Ile Glu Leu Gln Ile 
            420                 425                 430         


Leu Leu Pro Leu Gln Arg Ile Lys Asp Asn Gly Val Ile Pro Tyr Gln 
        435                 440                 445             


Leu His Leu Glu Glu Leu Lys Ala Ile Leu Ala Lys Cys Gly Pro Lys 
    450                 455                 460                 


Phe Pro Phe Leu Asn Glu Val Ala Asp Gly Phe Ser Val Ala Glu Lys 
465                 470                 475                 480 


Leu Ile Lys Met Leu Glu Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
                485                 490                 495     


Asn Thr His His Asn Val Asp Asn Gly Gly Phe Ala Trp Ala Val Arg 
            500                 505                 510         


Lys Ala Ser Gly Arg Val Thr Pro Trp Asn Phe Asp Asp Lys Ile Asp 
        515                 520                 525             


Arg Glu Lys Ser Ala Ala Ala Phe Ile Lys Asn Leu Thr Asn Lys Cys 
    530                 535                 540                 


Thr Tyr Leu Leu Gly Glu Asp Val Leu Pro Lys Ser Ser Leu Leu Tyr 
545                 550                 555                 560 


Ser Glu Phe Met Leu Leu Asn Glu Leu Asn Asn Val Arg Ile Asp Gly 
                565                 570                 575     


Lys Pro Leu Glu Lys Val Val Lys Glu His Leu Ile Glu Ala Val Phe 
            580                 585                 590         


Lys Gln Asp His Lys Lys Met Thr Lys Asn Arg Ile Glu Gln Phe Leu 
        595                 600                 605             


Lys Asp Asn Gly Tyr Ile Ser Glu Thr His Lys His Glu Ile Thr Gly 
    610                 615                 620                 


Leu Asp Gly Glu Ile Lys Asn Asp Leu Ala Ser Tyr Arg Asp Met Val 
625                 630                 635                 640 


Arg Ile Leu Gly Asp Gly Phe Asp Arg Ser Met Ala Glu Glu Ile Ile 
                645                 650                 655     


Thr Asp Ile Thr Ile Phe Gly Glu Ser Lys Lys Met Leu Arg Glu Thr 
            660                 665                 670         


Leu Arg Lys Lys Phe Ala Ser Cys Leu Asp Asp Glu Ala Ile Lys Lys 
        675                 680                 685             


Leu Thr Lys Leu Arg Tyr Arg Asp Trp Gly Arg Leu Ser Gln Lys Leu 
    690                 695                 700                 


Leu Asn Gly Ile Glu Gly Cys Asp Lys Ala Gly Asp Gly Thr Pro Glu 
705                 710                 715                 720 


Thr Ile Ile Ile Leu Met Arg Asn Phe Ser Tyr Asn Leu Met Glu Leu 
                725                 730                 735     


Leu Gly Asp Lys Phe Ser Phe Met Glu Arg Ile Gln Glu Ile Asn Ala 
            740                 745                 750         


Lys Leu Thr Glu Gly Gln Ile Val Asn Pro His Asp Ile Ile Asp Asp 
        755                 760                 765             


Leu Ala Leu Ser Pro Ala Val Lys Arg Ala Val Trp Gln Ala Leu Arg 
    770                 775                 780                 


Ile Val Asp Glu Val Ala His Ile Lys Lys Ala Leu Pro Ala Arg Ile 
785                 790                 795                 800 


Phe Val Glu Val Thr Arg Ser Asn Lys Asn Glu Lys Lys Lys Lys Asp 
                805                 810                 815     


Ser Arg Gln Lys Arg Leu Ser Asp Leu Tyr Ala Ala Ile Lys Lys Asp 
            820                 825                 830         


Asp Val Leu Leu Asn Gly Leu Asn Asn Glu Ile Phe Gly Glu Leu Lys 
        835                 840                 845             


Ser Ser Leu Ala Lys Tyr Asp Asp Ala Ala Leu Arg Ser Lys Lys Leu 
    850                 855                 860                 


Tyr Leu Tyr Tyr Thr Gln Met Gly Arg Cys Ala Tyr Thr Gly Glu Ile 
865                 870                 875                 880 


Ile Glu Leu Ser Leu Leu Asn Thr Asp Asn Tyr Asp Ile Asp His Ile 
                885                 890                 895     


Tyr Pro Arg Ser Leu Thr Lys Asp Asp Ser Phe Asp Asn Leu Val Leu 
            900                 905                 910         


Cys Lys Arg Thr Ala Asn Ala Gln Lys Ser Asp Ala Tyr Pro Ile Ser 
        915                 920                 925             


Glu Glu Ile Gln Lys Thr Gln Lys Pro Phe Trp Thr Phe Leu Lys Gln 
    930                 935                 940                 


Gln Gly Leu Ile Ser Glu Arg Lys Tyr Glu Arg Leu Thr Arg Ile Thr 
945                 950                 955                 960 


Pro Leu Thr Ala Asp Asp Leu Ser Gly Phe Ile Ala Arg Gln Leu Val 
                965                 970                 975     


Glu Thr Asn Gln Ser Val Lys Ala Ala Thr Thr Leu Leu Arg Arg Leu 
            980                 985                 990         


Tyr Pro Gly Val Asp Val Val Phe  Val Lys Ala Glu Asn  Val Thr Asp 
        995                 1000                 1005             


Phe Arg  His Asp Asn Asn Phe  Ile Lys Val Arg Ser  Leu Asn His 
    1010                 1015                 1020             


His His  His Ala Lys Asp Ala  Tyr Leu Asn Ile Val  Val Gly Asn 
    1025                 1030                 1035             


Val Tyr  His Glu Arg Phe Thr  Arg Asn Phe Arg Ala  Phe Phe Lys 
    1040                 1045                 1050             


Lys Asn  Gly Ala Asn Arg Thr  Tyr Asn Leu Ala Lys  Met Phe Asn 
    1055                 1060                 1065             


Tyr Asp  Val Asn Cys Thr Asn  Ala Lys Asp Gly Lys  Ala Trp Asp 
    1070                 1075                 1080             


Val Lys  Thr Ser Met Asp Thr  Val Lys Lys Met Met  Asp Ser Asn 
    1085                 1090                 1095             


Asp Val  Arg Val Thr Lys Arg  Leu Leu Glu Gln Thr  Gly Ala Leu 
    1100                 1105                 1110             


Ala Asp  Ala Thr Ile Tyr Lys  Ala Thr Val Ala Gly  Lys Ala Lys 
    1115                 1120                 1125             


Asp Gly  Ala Tyr Ile Gly Met  Lys Thr Lys Ser Ser  Val Phe Ala 
    1130                 1135                 1140             


Asp Val  Ser Lys Tyr Gly Gly  Met Thr Lys Ile Lys  Asn Ala Tyr 
    1145                 1150                 1155             


Ser Ile  Ile Val Gln Tyr Thr  Gly Lys Lys Gly Glu  Val Ile Lys 
    1160                 1165                 1170             


Glu Ile  Val Pro Leu Pro Ile  Tyr Leu Thr Asn Arg  Asn Thr Thr 
    1175                 1180                 1185             


Asp Gln  Asp Leu Ile Asn Tyr  Val Ala Ser Ile Ile  Pro Gln Ala 
    1190                 1195                 1200             


Lys Asp  Ile Ser Ile Ile Tyr  Gly Lys Leu Cys Ile  Asn Gln Leu 
    1205                 1210                 1215             


Val Lys  Val Asn Gly Phe Tyr  Tyr Tyr Leu Gly Gly  Lys Thr Asn 
    1220                 1225                 1230             


Ser Lys  Phe Cys Ile Asp Asn  Ala Ile Gln Val Ile  Val Ser Asn 
    1235                 1240                 1245             


Glu Trp  Ile Pro Tyr Leu Lys  Val Leu Glu Lys Phe  Asn Asn Met 
    1250                 1255                 1260             


Arg Lys  Asp Asn Lys Asp Leu  Lys Ala Asn Val Val  Ser Thr Arg 
    1265                 1270                 1275             


Ala Leu  Asp Asn Lys His Thr  Ile Glu Val Arg Ile  Val Glu Glu 
    1280                 1285                 1290             


Lys Asn  Ile Glu Phe Phe Asp  Tyr Leu Val Ser Lys  Leu Lys Met 
    1295                 1300                 1305             


Pro Ile  Tyr Gln Lys Met Lys  Gly Asn Lys Ala Ala  Glu Leu Ser 
    1310                 1315                 1320             


Glu Lys  Gly Tyr Gly Leu Phe  Lys Lys Met Ser Leu  Glu Glu Gln 
    1325                 1330                 1335             


Ser Ile  His Leu Ile Glu Leu  Leu Asn Leu Leu Thr  Asn Gln Lys 
    1340                 1345                 1350             


Thr Thr  Phe Glu Val Lys Pro  Leu Gly Ile Thr Ala  Ser Arg Ser 
    1355                 1360                 1365             


Thr Val  Gly Ser Lys Ile Ser  Asn Gln Asp Glu Phe  Lys Val Ile 
    1370                 1375                 1380             


Asn Glu  Ser Ile Thr Gly Leu  Tyr Ser Asn Glu Val  Thr Ile Val 
    1385                 1390                 1395             


<210> 614
<211> 1395
<212> PRT
<213> Veillonella sp.


<220>
<223> Veillonella sp. 6_1_27

<400> 614
Met Glu Thr Gln Ala Ser Asn Gln Leu Ile Ser Ser His Leu Lys Gly 
1               5                   10                  15      


Tyr Pro Ile Lys Asp Tyr Phe Val Gly Leu Asp Ile Gly Thr Ser Ser 
            20                  25                  30          


Val Gly Trp Ala Val Thr Asn Lys Ala Tyr Glu Leu Leu Lys Phe Arg 
        35                  40                  45              


Ser His Lys Met Trp Gly Ser Arg Leu Phe Asp Glu Gly Glu Ser Ala 
    50                  55                  60                  


Val Ala Arg Arg Gly Phe Arg Ser Met Arg Arg Arg Leu Glu Arg Arg 
65                  70                  75                  80  


Lys Leu Arg Leu Lys Leu Leu Glu Glu Leu Phe Ala Asp Ala Met Ala 
                85                  90                  95      


Gln Val Asp Pro Thr Phe Phe Met Arg Leu Arg Glu Ser Lys Tyr His 
            100                 105                 110         


Tyr Glu Asp Lys Thr Thr Gly His Ser Ser Lys His Ile Leu Phe Ile 
        115                 120                 125             


Asp Lys Asn Tyr Thr Asp Gln Asp Tyr Tyr Lys Glu Tyr Pro Thr Ile 
    130                 135                 140                 


Tyr His Leu Arg Val Ala Leu Met Lys Ser Gly Thr Asp Asp Ile Arg 
145                 150                 155                 160 


Lys Leu Phe Leu Ala Val His His Ile Leu Lys Tyr Arg Gly Asn Phe 
                165                 170                 175     


Leu Tyr Glu Gly Ala Thr Phe Asp Ser Asn Ala Ser Thr Leu Asp Asp 
            180                 185                 190         


Val Leu Lys Gln Ala Leu Glu Asn Ile Thr Phe Asn Cys Phe Asp Ser 
        195                 200                 205             


Ser Ala Ala Ile Gly Ser Ile Gly Gln Ile Leu Met Glu Leu Gly Lys 
    210                 215                 220                 


Thr Lys Ser Asp Lys Ala Lys Ala Ile Glu Arg Leu Val Asp Thr Tyr 
225                 230                 235                 240 


Ile Ile Thr Asp Glu Val Asp Thr Ser Gly Lys Thr Gln Lys Glu Gln 
                245                 250                 255     


Val Lys Glu Asp Lys Lys Arg Leu Lys Ser Phe Ala Asn Leu Val Leu 
            260                 265                 270         


Gly Leu Ser Ala Ser Leu Thr Asp Leu Phe Gly Ser Val Glu Asp Leu 
        275                 280                 285             


Asp Glu Asp Leu Lys Lys Leu Gln Ile Ile Gly Asp Thr Tyr Asp Glu 
    290                 295                 300                 


Arg Arg Asp Asp Leu Ala Lys Val Trp Gly Asp Glu Ile His Ile Ile 
305                 310                 315                 320 


Asp Asp Cys Lys Ser Val Tyr Asp Ala Ile Ile Leu Met Ser Ile Lys 
                325                 330                 335     


Glu Pro Gly Leu Thr Ile Ser Glu Ser Lys Val Lys Ala Phe Lys Lys 
            340                 345                 350         


His Lys Asp Asp Leu Ala Ile Leu Lys Ser Leu Leu Lys Ser Asp Arg 
        355                 360                 365             


Ser Ile Tyr Asn Thr Met Phe Lys Val Asp Glu Lys Gly Leu His Asn 
    370                 375                 380                 


Tyr Val His Tyr Ile Lys Gln Gly Arg Thr Glu Glu Thr Ser Cys Asn 
385                 390                 395                 400 


Arg Glu Asp Phe Tyr Lys Tyr Thr Lys Lys Val Val Glu Gly Leu Pro 
                405                 410                 415     


Asp Ser Lys Asp Lys Glu Tyr Ile Leu Ser Glu Ile Glu Leu Gln Thr 
            420                 425                 430         


Leu Leu Pro Leu Gln Arg Ile Lys Asp Asn Gly Val Ile Pro Tyr Gln 
        435                 440                 445             


Leu His Leu Glu Glu Leu Lys Val Ile Leu Ala Lys Cys Gly Pro Lys 
    450                 455                 460                 


Phe Pro Phe Leu Asn Glu Val Ala Asp Gly Phe Ser Val Ala Glu Lys 
465                 470                 475                 480 


Leu Ile Lys Met Leu Glu Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
                485                 490                 495     


Asn Thr His His Asn Val Asp Asn Gly Gly Phe Ala Trp Ala Val Arg 
            500                 505                 510         


Lys Ala Ser Gly Arg Val Thr Pro Trp Asn Phe Asp Asp Lys Ile Asp 
        515                 520                 525             


Arg Glu Lys Ser Ala Ala Ala Phe Ile Lys Asn Leu Thr Asn Lys Cys 
    530                 535                 540                 


Thr Tyr Leu Leu Gly Glu Asp Val Leu Pro Lys Ser Ser Leu Leu Tyr 
545                 550                 555                 560 


Ser Glu Phe Met Leu Leu Asn Glu Leu Asn Asn Val Arg Ile Asp Gly 
                565                 570                 575     


Lys Pro Leu Glu Lys Ala Val Lys Glu His Leu Ile Glu Ala Val Phe 
            580                 585                 590         


Lys Gln Asp His Lys Lys Met Thr Lys Asn Arg Ile Glu Gln Phe Leu 
        595                 600                 605             


Lys Asp Asn Asn Tyr Ile Pro Glu Lys His Lys Pro Glu Ile Thr Gly 
    610                 615                 620                 


Leu Asp Gly Glu Ile Lys Asn Asp Leu Ala Ser Tyr Arg Asp Met Val 
625                 630                 635                 640 


Arg Ile Leu Gly Asn Asn Phe Asp Leu Ser Met Ala Glu Glu Ile Ile 
                645                 650                 655     


Thr Asp Ile Thr Ile Phe Gly Glu Ser Lys Lys Met Leu Arg Glu Thr 
            660                 665                 670         


Leu Arg Asn Lys Phe Ser Ser Arg Leu Asp Asp Glu Ala Ile Lys Lys 
        675                 680                 685             


Leu Ser Lys Leu Arg Tyr Arg Asp Trp Gly Arg Leu Ser Arg Lys Leu 
    690                 695                 700                 


Leu Asn Val Ile Glu Gly Cys Asp Lys Ala Gly Asp Gly Thr Pro Glu 
705                 710                 715                 720 


Thr Ile Ile Ile Leu Met Arg Asn Phe Ser Tyr Asn Leu Met Glu Leu 
                725                 730                 735     


Leu Gly Asp Lys Phe Ser Phe Met Glu Arg Ile Gln Glu Ile Asn Ala 
            740                 745                 750         


Lys Leu Ile Glu Gly Gln Ile Val Asn Pro His Asp Ile Ile Asp Asp 
        755                 760                 765             


Leu Ala Leu Ser Pro Ala Val Lys Arg Ala Val Trp Gln Ala Leu Arg 
    770                 775                 780                 


Ile Val Asp Glu Ile Val His Ile Lys Lys Thr Leu Pro Ala Arg Ile 
785                 790                 795                 800 


Phe Val Glu Val Thr Arg Ser Asn Lys Ala Glu Lys Lys Lys Lys Asp 
                805                 810                 815     


Ser Arg Gln Lys Arg Leu Ser Asp Leu Tyr Ala Ala Ile Lys Lys Asp 
            820                 825                 830         


Asp Ala Leu Leu Ser Gly Leu Thr Asn Glu Glu Phe Gly Gly Leu Lys 
        835                 840                 845             


Ser Gly Leu Ala Lys Tyr Asp Asp Ala Ala Leu Arg Ser Lys Lys Leu 
    850                 855                 860                 


Tyr Leu Tyr Tyr Thr Gln Met Gly Arg Cys Ala Tyr Thr Gly Glu Val 
865                 870                 875                 880 


Ile Asp Leu Ser Gln Leu Asn Thr Asp Asn Tyr Asp Ile Asp His Ile 
                885                 890                 895     


Tyr Pro Arg Ser Leu Thr Lys Asp Asp Ser Phe Asp Asn Leu Val Leu 
            900                 905                 910         


Cys Lys Arg Thr Ala Asn Ala Gln Lys Ser Asp Thr Tyr Pro Ile Ser 
        915                 920                 925             


Lys Glu Ile Gln Lys Ala Gln Lys Ala Phe Trp Ile Phe Leu Lys Gln 
    930                 935                 940                 


Gln Gly Leu Ile Ser Glu Arg Lys Tyr Glu Arg Leu Thr Arg Ile Thr 
945                 950                 955                 960 


Pro Leu Thr Ala Asp Asp Leu Ser Gly Phe Ile Ala Arg Gln Leu Val 
                965                 970                 975     


Glu Thr Asn Gln Ser Val Lys Ala Ala Thr Thr Leu Leu Arg Arg Leu 
            980                 985                 990         


Tyr Pro Gly Val Asp Val Val Phe  Val Lys Ala Glu Asn  Val Thr Asp 
        995                 1000                 1005             


Phe Arg  His Asp Asn Asp Phe  Ile Lys Val Arg Ser  Leu Asn His 
    1010                 1015                 1020             


His His  His Ala Lys Asp Ala  Tyr Leu Asn Ile Val  Val Gly Asn 
    1025                 1030                 1035             


Val Tyr  His Glu Arg Phe Thr  Arg Asn Phe Arg Ala  Phe Phe Lys 
    1040                 1045                 1050             


Lys Asn  Gly Ala Asn Arg Thr  Tyr Asn Leu Ala Lys  Met Phe Asn 
    1055                 1060                 1065             


Tyr Asp  Val Lys Cys Thr Asn  Ala Lys Asp Gly Lys  Ala Trp Ala 
    1070                 1075                 1080             


Val Lys  Thr Ser Met Asp Thr  Val Lys Lys Met Met  Asp Ser Asn 
    1085                 1090                 1095             


Asp Val  Arg Val Thr Lys Arg  Val Tyr Glu Gln Lys  Gly Gln Leu 
    1100                 1105                 1110             


Ser Asp  Ile Asn Leu Thr Lys  Ala Ser Lys Val Lys  Ala Asp Ile 
    1115                 1120                 1125             


Tyr Leu  Pro Ile Lys Ala Asn  Asp Pro Ile Met Ser  Gln Asn Met 
    1130                 1135                 1140             


Lys Tyr  Gly Gly Tyr Ser Asp  Ile Lys Asn Ala Tyr  Tyr Thr Ile 
    1145                 1150                 1155             


Ile Glu  Tyr Ser Asp Lys Lys  Asn Asn Ser Ile Lys  Ala Phe Ile 
    1160                 1165                 1170             


Pro Ile  Pro Ile Phe Ile Ala  Thr Lys Thr Leu Thr  Lys Gln Ala 
    1175                 1180                 1185             


Leu Leu  Glu Tyr Ile Lys Thr  Val Leu Pro Lys Ala  Asn Asn Leu 
    1190                 1195                 1200             


Arg Ile  Ile Tyr Lys Lys Val  Tyr Asn Asp Gln Leu  Leu Lys Ile 
    1205                 1210                 1215             


Asp Gly  Phe Asn Tyr Tyr Leu  Gly Gly Arg Ser Asn  Asp Arg Phe 
    1220                 1225                 1230             


Cys Ile  Asp Asn Ala Ile Gln  Leu Ile Val Pro Leu  Glu Ile Gln 
    1235                 1240                 1245             


Phe Tyr  Ile Lys Leu Val Glu  Lys Phe Thr Ala Ile  Ile Ser Glu 
    1250                 1255                 1260             


Asn Lys  Asn Ile Ala Leu Lys  Ala Ser Ser Val Lys  Ser Arg Asn 
    1265                 1270                 1275             


Pro Ile  Asn Asn Gln Val Glu  Asn Ile Thr Leu Glu  Tyr Thr Gln 
    1280                 1285                 1290             


Lys Leu  Phe Asp Tyr Leu Val  Ser Lys Phe Asn Glu  Leu Ile Tyr 
    1295                 1300                 1305             


Leu Lys  Met Arg Gly Asn Lys  Leu Thr Asp Val Asn  Asn Ile Gly 
    1310                 1315                 1320             


Arg Lys  Gln Phe Ile Lys Leu  Ser Leu Glu Glu Arg  Cys Lys Ala 
    1325                 1330                 1335             


Leu Ala  Glu Leu Leu Asn Ile  Phe Thr Asn Met Asn  Lys Lys Leu 
    1340                 1345                 1350             


Ser Leu  Ser Thr Ile Asn Val  Ser Ala Ser Arg Lys  Val Val Asn 
    1355                 1360                 1365             


Phe Lys  Ile Ser Ser Leu Asp  Glu Phe Lys Ile Val  Asn Glu Ser 
    1370                 1375                 1380             


Ile Thr  Gly Leu Tyr Ser His  Glu Ile Thr Ile Val  
    1385                 1390                 1395 


<210> 615
<211> 1120
<212> PRT
<213> Veillonella sp.


<220>
<223> Veillonella sp. oral taxon 780 str. F0422

<400> 615
Met Gly Phe Lys Ala Asn Leu Val Asn Leu Phe Thr Asp Glu Asp Ile 
1               5                   10                  15      


Glu Val Ile Leu Pro Glu Glu Lys Glu Phe Lys Ser Ile Asn Leu His 
            20                  25                  30          


Glu Gly Ile Tyr Glu Asp Val Arg Asp Ala Tyr Glu Asp Ala Trp Gly 
        35                  40                  45              


Asp Arg Phe Ala Ile Val Asp Gln Cys Lys Val Leu His Asp Ile Ile 
    50                  55                  60                  


Val Ile Ser Ser Ile Ile Lys Pro Gly Gln Ser Leu Ser Glu Ala Lys 
65                  70                  75                  80  


Ile Glu Ser Tyr Asn Gln His Lys Glu Asp Leu Val Leu Leu Lys Ser 
                85                  90                  95      


Val Leu Lys Glu Asp Arg Lys Leu Tyr Asp Asp Met Phe Val Val Asp 
            100                 105                 110         


Thr Asp Lys Gly Thr Asn Tyr Val Lys Tyr Thr Lys Gln Gly Val Asn 
        115                 120                 125             


Gly Asn Thr Ser Ala Thr Gln Glu Glu Phe Tyr Lys Tyr Val Arg Lys 
    130                 135                 140                 


Val Val Ser Val Leu Pro Glu Thr Glu His Thr Arg Arg Ile Val Gln 
145                 150                 155                 160 


Lys Leu Glu Glu Gly Thr Phe Leu Pro Leu Gln Arg Ile Ser Lys Asn 
                165                 170                 175     


Gly Val Val Pro Tyr Gln Leu His Lys Glu Glu Leu Val Arg Ile Leu 
            180                 185                 190         


Asp Lys Ala Thr Val Asn Phe Pro Phe Leu Asn Lys Val Glu Asn Gly 
        195                 200                 205             


Leu Thr Val Ala Asp Lys Ile Ile Ser Ile Leu Glu Phe Lys Ile Pro 
    210                 215                 220                 


Tyr Tyr Val Gly Pro Leu Asn Pro Thr His Ser Ile Glu Asn Gly Gly 
225                 230                 235                 240 


Phe Ala Trp Val Val Arg Lys Glu Ala Gly Gln Val Leu Pro Trp Asn 
                245                 250                 255     


Phe Glu Gln Lys Val Asp Val Gln Ala Ser Ala Val Lys Phe Ile Glu 
            260                 265                 270         


Asn Leu Thr Asn Lys Cys Thr Tyr Leu Ile Asp Gln Asp Val Leu Pro 
        275                 280                 285             


Lys Tyr Ser Leu Leu Tyr Ala Glu Phe Ser Leu Leu Asn Glu Leu Asn 
    290                 295                 300                 


Asn Ile Arg Val Asn Asp Lys Pro Leu Pro Ala Asp Val Lys Gln Ala 
305                 310                 315                 320 


Phe Ile Arg Asp His Phe Ile Ser Leu Gln Asp Ser Lys Thr Ala Thr 
                325                 330                 335     


Lys Lys Val Val Ala Lys Tyr Leu Val Asp Asn Asn Tyr Val Ser Gln 
            340                 345                 350         


Pro Pro Ile Ile Thr Gly Met Asp Gln Gln Ile Ala Thr Lys Leu Thr 
        355                 360                 365             


Ser His Arg Asp Met Thr Arg Ile Leu Gly Glu His Phe Asp His Ala 
    370                 375                 380                 


Met Ala Glu Asp Ile Ile Arg Tyr Ile Thr Ile Phe Gly Glu Ser Lys 
385                 390                 395                 400 


Asp Met Leu Arg Gln Val Leu Lys Asn Tyr Tyr Gly Asp Arg Leu Thr 
                405                 410                 415     


Thr Glu Gln Ile Lys Lys Leu Gly Lys Leu Thr Tyr Thr Gly Trp Gly 
            420                 425                 430         


Arg Leu Ser Lys Lys Phe Leu Ser Asp Ile Trp Gly Met Lys Lys Asn 
        435                 440                 445             


Asp Asp Asp Ala Glu Ala Gly Thr Ile Ile Glu His Met Arg Glu Gly 
    450                 455                 460                 


Gln Glu Asn Leu Met Gln Leu Leu Ser Ser Ser Tyr Ser Phe Ile Asp 
465                 470                 475                 480 


Val Val Gln Glu Tyr Val Thr Asn Val Leu Gly Glu Lys Glu Lys Thr 
                485                 490                 495     


Ala Phe Glu Met Leu Glu Asp Leu Ser Leu Ser Pro Met Val Lys Arg 
            500                 505                 510         


Ser Val Trp Gln Thr Leu Arg Ile Leu Asp Glu Ile Val Ser Ile Arg 
        515                 520                 525             


Lys Glu Leu Pro Lys Lys Ile Phe Val Glu Val Ala Arg Thr Asn Lys 
    530                 535                 540                 


Ala Asp Lys Lys Arg Thr Gln Ser Arg Lys Ala Leu Leu Glu Glu Leu 
545                 550                 555                 560 


Tyr Lys Gln Ile Lys Asp Glu Asp Val His Val Leu Gln Gln Glu Leu 
                565                 570                 575     


Glu Ser Lys Glu Asp Ser Ala Leu Asn Ser Lys Lys Leu Tyr Leu Tyr 
            580                 585                 590         


Phe Thr Gln Met Gly Arg Cys Met Tyr Ser Gly Arg Arg Ile Asp Ile 
        595                 600                 605             


His Glu Leu Phe Thr Asp Lys Tyr Asp Ile Asp His Ile Tyr Pro Arg 
    610                 615                 620                 


Ser Leu Thr Lys Asp Asp Ser Trp His Asn Ile Val Leu Val Glu Lys 
625                 630                 635                 640 


Gln Leu Asn Ala Glu Lys Thr Asp Arg Phe Pro Ile Leu Ser Ala Ile 
                645                 650                 655     


Gln Ser Lys Gln Lys Gly Phe Trp Lys Leu Leu Trp Asp Arg Gly Phe 
            660                 665                 670         


Ile Ser Glu Lys Lys Tyr Asp Arg Leu Val Arg Thr Thr Asp Leu Thr 
        675                 680                 685             


Asp Glu Glu Leu Asn Gln Phe Ile Asn Arg Gln Met Val Ser Thr Asn 
    690                 695                 700                 


Gln Ser Val Lys Ala Val Thr Thr Leu Leu His Gln Leu Tyr Pro Glu 
705                 710                 715                 720 


Thr Glu Val Val Phe Ser Lys Ala Glu Asn Val Ser Asp Phe Arg His 
                725                 730                 735     


Asp Tyr Asp Phe Val Lys Val Arg Ser Ile Asn His His His His Ala 
            740                 745                 750         


Lys Asp Ala Tyr Leu Asn Ile Val Val Gly Asn Val Tyr His Glu Lys 
        755                 760                 765             


Phe Thr Lys Asn Phe Leu Ser Phe Ala Lys Gln Lys Gly Thr Arg Arg 
    770                 775                 780                 


Thr Tyr Asn Leu Thr Lys Ile Phe Glu Tyr Glu Ile Lys Leu Thr Glu 
785                 790                 795                 800 


Glu Ser Lys Lys Val Ile Trp Asp Pro Asn Ile His Met Asp Ile Val 
                805                 810                 815     


Lys Lys Met Met Lys Ser Asn Asp Val Arg Val Thr Gln Arg Ala Val 
            820                 825                 830         


Pro Gln Lys Gly Gly Leu Ser Asp Glu Thr Ile Tyr Lys Lys Gly Ile 
        835                 840                 845             


Ala Lys Arg Gly Val Tyr Leu Pro Leu Lys Ser Ser Asp Glu Arg Val 
    850                 855                 860                 


Arg Asp Val Glu Lys Tyr Gly Gly Arg Thr Ser Ile Thr Ile Ser Glu 
865                 870                 875                 880 


Tyr Ile Ile Leu Asn Ile Arg Asp Thr Ser Asp Gln Asp Arg Ile Glu 
                885                 890                 895     


Ile Phe Ser Leu Pro Leu Tyr Ile Ala Gly Lys Lys Asp Ile His Lys 
            900                 905                 910         


Ala Ile Glu Glu Ala Tyr Leu Ser Thr Cys Lys Lys Pro Ala Ser Val 
        915                 920                 925             


Val Asp Ile Gln Ile Leu Tyr Arg Gly Leu Tyr Ile Gly Ser Lys Val 
    930                 935                 940                 


Asn Ile Asn Gly Phe Thr Tyr Tyr Met Gly Gly Lys Thr Gly Ser Asn 
945                 950                 955                 960 


Val Ser Ile Asp Ser Ala Val Asp Val Val Met Asp Ile Thr Ser Ser 
                965                 970                 975     


Val Tyr Ile Lys Leu Leu Glu Lys Val Ala Ile Lys Lys Ile Glu Asn 
            980                 985                 990         


Pro Lys Thr Phe Arg Ile Glu Asn  Ile Lys Thr Ser Tyr  Asn His Lys 
        995                 1000                 1005             


Glu Val  Thr Val Ser Lys Glu  Gln Asn Ile Ala Leu  Tyr Gln Glu 
    1010                 1015                 1020             


Leu Leu  Lys Lys Leu Asp Thr  Pro Leu Phe Ser Lys  Met Lys Gly 
    1025                 1030                 1035             


Asn Lys  Leu Glu Glu Phe Arg  Thr Val Gly Phe Asp  Thr Phe Ile 
    1040                 1045                 1050             


Ala Leu  Ser Leu Glu Glu Gln  Ala Ser Val Leu Leu  Glu Val Leu 
    1055                 1060                 1065             


Asn Val  Leu Thr Asn Phe Lys  Thr Lys Arg Asp Ile  Thr Lys Ile 
    1070                 1075                 1080             


Gly Met  Thr Ser Ser Arg Ser  Thr Leu Gly Ile Asn  Ile Ser Asn 
    1085                 1090                 1095             


Thr Glu  Gln Phe Ser Val Ile  Thr Thr Ser Ile Thr  Gly Leu Tyr 
    1100                 1105                 1110             


Glu Gln  Glu Ile Lys Ile Lys  
    1115                 1120 


<210> 616
<211> 1068
<212> PRT
<213> Verminephrobacter eiseniae

<400> 616
Met Asn Lys Ala Val Ala Tyr Arg Leu Ala Leu Asp Leu Gly Ser Thr 
1               5                   10                  15      


Ser Leu Gly Trp Ala Ile Phe Arg Leu Asn Glu Ala Arg Glu Pro Thr 
            20                  25                  30          


Ala Ile Ile Arg Ala Gly Val Arg Ile Phe Ser Asp Gly Arg Asn Ala 
        35                  40                  45              


Asn Ser Glu Pro Leu Ala Val His Arg Arg Val Ala Arg Ala Met Arg 
    50                  55                  60                  


Arg Arg Arg Asp Arg Leu Leu Lys Arg Lys Lys Arg Met His Asp Gln 
65                  70                  75                  80  


Leu Val Gln His Gly Phe Phe Pro Ala Glu Val Ala Glu Arg Lys Glu 
                85                  90                  95      


Leu Glu Arg Leu Asn Pro Tyr Gln Leu Arg Ala Lys Gly Leu His Glu 
            100                 105                 110         


Ala Leu Thr Pro Gly Glu Phe Ala Arg Ala Leu Phe His Ile Asn Gln 
        115                 120                 125             


Arg Arg Gly Phe Lys Ser Asn Arg Lys Thr Asp Arg Lys Asp Asn Asp 
    130                 135                 140                 


Ser Gly Ala Leu Lys Gln Ala Ile Ser Glu Leu Arg Lys Arg Ile Gln 
145                 150                 155                 160 


Asp Ser Asp Cys Ala Thr Ala Gly Glu Trp Phe Trp Lys Glu Arg Met 
                165                 170                 175     


Gln Gln Lys Pro Glu Gly Val Arg Gly Gln Trp Val Arg Ala Arg Tyr 
            180                 185                 190         


Arg Lys Thr Pro Ser Thr Thr Asp Glu Gly Lys Lys Arg Ile Gly Tyr 
        195                 200                 205             


Asp Leu Tyr Val Asp Arg Ala Met Val Glu Gln Glu Phe Asp Ala Leu 
    210                 215                 220                 


Trp Ala Ala Gln Ala Ala Leu Gln Pro Gly Leu Phe Thr Glu Ala Ala 
225                 230                 235                 240 


Arg Ala Glu Leu Lys Asp Thr Leu Leu Tyr Gln Arg Asp Leu Arg Pro 
                245                 250                 255     


Val Lys Pro Gly Arg Cys Thr Leu Leu Pro Ala Glu Glu Arg Ala Pro 
            260                 265                 270         


Leu Ala Leu Pro Ser Thr Gln Arg Phe Arg Ile Leu Gln Glu Val Asn 
        275                 280                 285             


Asn Leu Arg Leu Leu Asp Glu Ala Leu Arg Glu Val Pro Leu Asn Leu 
    290                 295                 300                 


Ala Gln Arg Asp Ala Val Val Ser Ala Leu Glu Gly Lys Lys Glu Leu 
305                 310                 315                 320 


Ser Phe Ala Ala Ile Arg Lys Leu Leu Thr Leu Ser Gly Lys Phe Asn 
                325                 330                 335     


Leu Glu Asp Glu Lys Arg Ala Glu Leu Lys Gly Asn Ala Thr Ser Val 
            340                 345                 350         


Ile Leu Ala Arg Lys Asp Leu Phe Gly Asp Ala Trp Ala Gly Phe Asp 
        355                 360                 365             


Ala Ala Val Gln Asp Glu Ile Val Trp Arg Leu Val Ser Gln Glu Ser 
    370                 375                 380                 


Glu Gly Ala Leu Ile Ala Trp Leu Gln Gln His Thr Gly Val Asp Gly 
385                 390                 395                 400 


Val Cys Ala Glu Ala Ile Val Asn Thr Arg Leu Pro Asp Gly Tyr Gly 
                405                 410                 415     


Arg Leu Ser Arg Lys Ala Leu Glu Arg Ile Val Pro Ala Leu Gln Arg 
            420                 425                 430         


Glu Val Cys Thr Tyr Asp Lys Ala Val Gln Ala Ala Gly Phe Ala His 
        435                 440                 445             


His Ser Asp Leu Gly Phe Asp Phe Asp Tyr Ala Glu Asp Glu Val Gln 
    450                 455                 460                 


Gln Val Gly Glu His Thr Ile Ala Ser Thr Gly Glu Val Gln Ala Gln 
465                 470                 475                 480 


Tyr Ala Phe Lys Gln Leu Pro Tyr Tyr Gly Lys Ala Leu Gln Arg His 
                485                 490                 495     


Val Ala Phe Gly Ser Gly Asp Ala Lys Asp His Glu Glu Lys Cys Tyr 
            500                 505                 510         


Gly Lys Ile Ala Asn Pro Thr Val His Ile Gly Leu Asn Gln Val Arg 
        515                 520                 525             


Thr Val Val Asn Ala Leu Ile Arg Arg Tyr Gly His Pro Thr Glu Val 
    530                 535                 540                 


Val Val Glu Leu Ala Arg Asp Leu Lys Gln Ser Arg Glu Gln Lys Gln 
545                 550                 555                 560 


Gln Thr Gln Arg Glu Gln Ala Asp Asn Gln Lys Arg Asn Glu Asp Ile 
                565                 570                 575     


Arg Lys Arg Ile Ala Pro Ile Leu Glu Thr Ser Pro Glu Arg Val Arg 
            580                 585                 590         


Asp Arg Asp Ile Lys Lys Trp Ile Leu Trp Glu Glu Leu Asn Lys Lys 
        595                 600                 605             


Asp Ile Ala Asp Arg His Cys Pro Tyr Ser Gly Glu Arg Ile Ser Ala 
    610                 615                 620                 


Thr Met Leu Leu Ser Glu Ala Val Glu Ile Glu His Ile Leu Pro Phe 
625                 630                 635                 640 


Ser Arg Thr Leu Asp Asp Ser Leu Asn Asn Arg Thr Val Ala Met Arg 
                645                 650                 655     


Arg Ala Asn Arg Ile Lys Gly Asp Arg Thr Pro Trp Glu Ala Arg Ala 
            660                 665                 670         


Asp Phe Glu Ala Gln Gly Trp Arg Tyr Glu Ala Ile Leu Gln Arg Ala 
        675                 680                 685             


Glu Gly Met Pro Pro Arg Lys Arg Tyr Arg Phe Ala Glu Asp Gly Tyr 
    690                 695                 700                 


Gln Arg Trp Leu Gly Lys Asp Arg Asn Phe Leu Ala Arg Ala Leu Asn 
705                 710                 715                 720 


Asp Thr Ser Tyr Leu Ser Arg Leu Ala Ala Asn Tyr Leu Arg Leu Val 
                725                 730                 735     


Cys Pro Gln Gly Val Arg Val Ile Pro Gly Gln Met Thr Asp Lys Leu 
            740                 745                 750         


Arg Gly Lys Phe Gly Leu Asn Ser Val Leu Gly Leu Asp Gly Lys Lys 
        755                 760                 765             


Asn Arg Asn Asp His Arg His His Ala Val Asp Ala Cys Val Ile Gly 
    770                 775                 780                 


Val Thr Asp Gln Gly Leu Met Gln Arg Phe Ala Asn Ala Ser Lys Gln 
785                 790                 795                 800 


Ala Arg Glu Asn Gly Leu Thr Arg Leu Val Gln Asp Met Leu Leu Pro 
                805                 810                 815     


Trp Trp Pro Ser Tyr Tyr Asp His Val Glu Arg Ala Val Arg His Ile 
            820                 825                 830         


Arg Val Ser His Arg Pro Asp His Gly Phe Glu Gly Ala Met Met Lys 
        835                 840                 845             


Gly Thr Ala His Gly Ile Arg Glu Asp Gly Ile Arg Glu Asp Gly Arg 
    850                 855                 860                 


Ile Lys Gln Arg Pro Lys Ala Lys Gly Ser Ala Asp His Lys Thr Ile 
865                 870                 875                 880 


Thr Leu Ile Pro Ile Asp Glu Pro Arg Gln Leu Ala Arg His Gly Val 
                885                 890                 895     


Asp Ala Glu Gly Lys Pro Leu Pro Tyr Lys Gly Tyr Ala Ser Gly Ser 
            900                 905                 910         


Asn Tyr Cys Ile Glu Ile Thr Lys Asn Gly Lys Gly Lys Trp Glu Gly 
        915                 920                 925             


Gln Val Ile Ser Thr Phe Asp Ala Tyr Arg Ile Lys Ala Ala Ala Asp 
    930                 935                 940                 


Ala Ala Ala Arg Ala Gly Gln Val Ile Ser Thr Val Glu Ala Asp Ser 
945                 950                 955                 960 


Ile Val Arg Lys Ser Gly Trp Glu Arg Leu Arg Gly Ala Gln Ser Gln 
                965                 970                 975     


Asn Gly Gln Pro Leu Val Met Arg Leu Val Ile Gly Asp Ser Val Arg 
            980                 985                 990         


Met Glu Val Asp Gly Arg Asp Glu  Val Met Arg Val Val  Lys Met Ser 
        995                 1000                 1005             


Gly Lys  Glu Met Val Phe Ala  Pro Val Arg Glu Ala  Asn Val Asp 
    1010                 1015                 1020             


Lys Arg  Asn Asn Met Pro Asp  Glu Gln Asp Pro Phe  Thr Tyr Thr 
    1025                 1030                 1035             


Tyr Lys  Arg Ala Asp Gln Leu  Arg Lys Ala Lys Ala  Arg Gln Val 
    1040                 1045                 1050             


Thr Ile  Ser Pro Ile Gly Glu  Leu Arg Asp Pro Gly  Phe Lys Gly 
    1055                 1060                 1065             


<210> 617
<211> 1440
<212> PRT
<213> Weeksella virosa

<400> 617
Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Glu Gln Asp Phe Glu Asn Lys Gln Gly Leu Ile Leu Gly 
            20                  25                  30          


Met Gly Ser Arg Ile Ile Pro Met Asp Ala Gly Ile Ile Gly Lys Phe 
        35                  40                  45              


Ala Glu Gly Ser Ser Ile Ser Gln Thr Ala Glu Arg Thr Gly Tyr Arg 
    50                  55                  60                  


Ser Ile Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu Asn Ile Leu Lys Phe Leu Pro Glu His Tyr Ala Ala 
                85                  90                  95      


Glu Ile Asp Phe Glu Lys Arg Phe Gly Gln Phe Leu Ala Glu Thr Glu 
            100                 105                 110         


Pro Lys Leu Ala Trp Lys Lys Asn Ala Glu Gly Lys Phe Glu Phe Leu 
        115                 120                 125             


Phe Gln Arg Ser Phe Asp Glu Met Val Ala Asp Phe Lys Ala Asn Gly 
    130                 135                 140                 


Gln Asp Ile Lys Ile Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys 
145                 150                 155                 160 


Lys Ala Leu Thr Gln Lys Ile Ser Pro Gln Glu Leu Ala Trp Ile Ile 
                165                 170                 175     


Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu 
            180                 185                 190         


Glu Glu Glu Asn Pro Asn Lys Lys Val Glu Phe Tyr Ser Leu Lys Ile 
        195                 200                 205             


Val Asp Val Val Ala Asp Glu Gln Pro Asn Lys Lys Gly Asp Thr Trp 
    210                 215                 220                 


Tyr Ser Leu His Leu Glu Asn Gly Trp Val Tyr Arg Arg Ser Ser Lys 
225                 230                 235                 240 


Ile Pro Leu Tyr Asp Trp Lys Asp Lys Val Arg Asp Phe Ile Val Thr 
                245                 250                 255     


Thr Asp Ile Asn Glu Asp Gly Ser Glu Lys Leu Asp Lys Asp Gly Glu 
            260                 265                 270         


Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp Asp Trp Thr Leu Ile 
        275                 280                 285             


Lys Lys Lys Thr Glu Gln Glu Ile Glu Gln Phe Asn Gln Thr Val Gly 
    290                 295                 300                 


Ser Tyr Ile Tyr Glu Ala Leu Leu Asp Asn Pro Thr Gln Lys Ile Arg 
305                 310                 315                 320 


Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Phe Tyr Lys Ser Glu Leu 
                325                 330                 335     


Lys Lys Ile Leu Glu Lys Gln Ile Glu Leu Gln Pro Glu Leu Phe Thr 
            340                 345                 350         


Glu Asp Leu Tyr Asn Ala Cys Ala Arg Glu Leu Tyr Arg Arg Asn Val 
        355                 360                 365             


Ala His Gln Gln Gln Leu Ser Ser Arg Asp Phe Val Tyr Leu Phe Leu 
    370                 375                 380                 


Asn Asp Ile Ile Phe Tyr Gln Arg Pro Leu Arg Ser Gln Lys Ser Leu 
385                 390                 395                 400 


Ile Ser Asn Cys Ser Leu Glu Phe Arg Thr Ile Lys Asp Lys Asp Gly 
                405                 410                 415     


Asn Gly Gln Ile Ile Tyr Leu Lys Ala Ile Pro Lys Ser Asn Pro Tyr 
            420                 425                 430         


Tyr Gln Glu Phe Arg Val Trp Gln Trp Leu Tyr Asn Leu Lys Ile Phe 
        435                 440                 445             


Thr Lys Glu Asp Asp Lys Asp Val Thr Asn Gln Phe Ile Asn Lys Val 
    450                 455                 460                 


Glu Asp Leu Glu Ala Leu Phe Glu Phe Leu Met Asn Gln Lys Glu Val 
465                 470                 475                 480 


Asn His Thr Asp Ile Leu Thr Tyr Leu Ile Glu Pro Ile Val Lys Ser 
                485                 490                 495     


Lys Tyr Pro Asn Ala Lys Gly Lys Ala Phe Lys Asp Glu Leu Lys Lys 
            500                 505                 510         


Glu Leu Lys Lys Tyr Arg Trp Asn Tyr Val Tyr Asp Ala Asp Lys Asp 
        515                 520                 525             


Glu Ser Lys Ser Tyr Pro Met Asn Glu Thr Arg Tyr Glu Leu Arg Lys 
    530                 535                 540                 


Arg Leu Asp Lys Val Glu Asn Val Pro Ala Asp Phe Met Thr Arg Lys 
545                 550                 555                 560 


Ile Glu Gln His Leu Trp His Ile Ile Tyr Ser Val Thr Asp Lys Ile 
                565                 570                 575     


Glu Phe Glu Lys Ala Leu Lys Ser Phe Ala Asn Lys Tyr Asp Leu His 
            580                 585                 590         


Gln Glu Ser Phe Val Glu Asn Phe Lys Arg Phe Lys Pro Phe Asp Ser 
        595                 600                 605             


Asp Tyr Gly Thr Tyr Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro Leu 
    610                 615                 620                 


Met Arg Val Gly Lys Tyr Trp Ser Trp Asp Ile Ile Asp Asp Lys Thr 
625                 630                 635                 640 


Lys Thr Arg Ile Gly Lys Ile Ile Thr Gly Glu Tyr Asp Glu Thr Ile 
                645                 650                 655     


Lys Asn Arg Val Arg Glu Lys Ala Ile Asp Leu Thr Glu Glu Asn His 
            660                 665                 670         


Phe Gln Gly Leu Gln Leu Trp Leu Ala Gln Tyr Ile Val Tyr Asp Arg 
        675                 680                 685             


His Ser Glu Ala Asp Ile Ala Gly Lys Trp Asn Ser Val Ala Asp Leu 
    690                 695                 700                 


Glu Gln Tyr Leu Ser Glu Phe Lys Gln His Ser Leu Arg Asn Pro Ile 
705                 710                 715                 720 


Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val Val Arg Asp Ile Trp 
                725                 730                 735     


Lys Gln Tyr Gly Lys Gly Ala Lys Asp Tyr Phe Asp Glu Ile His Ile 
            740                 745                 750         


Glu Leu Gly Arg Glu Met Lys Asn Thr Ala Glu Glu Arg Lys Arg Leu 
        755                 760                 765             


Ser Ser Ile Ile Ser Glu Asn Glu Thr Thr Asn Leu Arg Ile Arg Ala 
    770                 775                 780                 


Ile Leu Glu Glu Leu Met Tyr Asp Glu Asn Met Glu Asn Val Arg Pro 
785                 790                 795                 800 


Tyr Ser Pro Met Gln Gln Glu Ala Leu Lys Ile Tyr Glu Asp Gly Val 
                805                 810                 815     


Leu Ser Ser Ser Val Glu Ile Pro Glu Asp Ile Glu Lys Ile Ser Lys 
            820                 825                 830         


Lys Ser Glu Pro Thr Lys Ser Glu Ile Gln Arg Tyr Lys Leu Trp Leu 
        835                 840                 845             


Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Arg Pro Ile Pro Leu Ser 
    850                 855                 860                 


Lys Leu Phe Thr Pro Ala Tyr Gln Ile Glu His Ile Ile Pro Gln Ala 
865                 870                 875                 880 


Arg Phe Phe Asp Asp Gly Phe Ser Asn Lys Val Ile Cys Glu Ser Glu 
                885                 890                 895     


Val Asn Ala Leu Lys Asp Lys Met Leu Gly Leu Glu Phe Ile Gln Asn 
            900                 905                 910         


Tyr Tyr Gly Gln Lys Val Thr Thr Ser Phe Gly Glu Val Thr Ile Leu 
        915                 920                 925             


Thr Glu Asp Ala Tyr Lys Ala Phe Val Lys Glu His Tyr Asp Lys Asn 
    930                 935                 940                 


Arg Ser Lys Arg Asn Lys Leu Leu Leu Glu Glu Ile Pro Glu Lys Met 
945                 950                 955                 960 


Ile Asp Arg Gln Met Asn Asp Thr Arg Tyr Ile Ser Lys Tyr Ile Ser 
                965                 970                 975     


Lys Val Leu Ser Asn Leu Val Arg Gly Glu Lys Asp Asp Glu Gly Val 
            980                 985                 990         


Asn Ser Lys Asn Ile Ile Pro Gly  Asn Gly Lys Ile Thr  Gly Ile Leu 
        995                 1000                 1005             


Lys Gln  Asp Trp Gly Leu Asn  Asp Val Trp Asn Asp  Leu Ile Leu 
    1010                 1015                 1020             


Pro Arg  Phe Glu Arg Met Asn  Gln Leu Thr Asn Ser  Thr Asp Phe 
    1025                 1030                 1035             


Thr Ala  Trp Asn Glu Lys His  Gln Lys Phe Leu Pro  Ser Val Pro 
    1040                 1045                 1050             


Leu Glu  Leu Ser Lys Gly Phe  Gln Lys Lys Arg Ile  Asp His Arg 
    1055                 1060                 1065             


His His  Ala Leu Asp Ala Leu  Ile Ile Ala Cys Ala  Thr Arg Asp 
    1070                 1075                 1080             


His Val  Asn Leu Leu Asn Asn  Lys His Ala Lys Ser  Arg Asn Glu 
    1085                 1090                 1095             


Arg Tyr  Asp Leu Gln His Lys  Leu Arg His Thr Thr  Pro Trp Gln 
    1100                 1105                 1110             


Asp Lys  Glu Gly Lys Val Arg  Thr Lys Phe Thr Glu  Phe Lys Lys 
    1115                 1120                 1125             


Pro Trp  Glu Thr Phe Thr Gln  Asp Thr Lys Lys Glu  Leu Glu Lys 
    1130                 1135                 1140             


Ile Val  Val Asn Phe Lys Gln  Asn Leu Arg Val Ile  Asn Lys Ala 
    1145                 1150                 1155             


Thr Asn  Tyr Tyr Glu Lys Ile  Val Asp Gly Lys Lys  Val Met Phe 
    1160                 1165                 1170             


Lys Gln  Glu Gly Val Asn Trp  Ala Ile Arg Lys Pro  Met His Lys 
    1175                 1180                 1185             


Glu Thr  Val Ser Gly Lys Ile  Asp Leu Pro Arg Val  Lys Val Ser 
    1190                 1195                 1200             


Lys Gly  Lys Ile Leu Thr Ala  Thr Arg Lys Ser Leu  Asp Thr Ser 
    1205                 1210                 1215             


Phe Asn  Ala Lys Thr Ile Leu  Ser Ile Thr Asp Thr  Gly Ile Gln 
    1220                 1225                 1230             


Lys Ile  Leu Leu Asn Tyr Leu  Lys Ala Lys Gly Asn  Pro Glu Leu 
    1235                 1240                 1245             


Ala Phe  Ser Pro Glu Gly Ile  Glu Glu Met Asn Gln  Asn Ile Ser 
    1250                 1255                 1260             


Leu Tyr  Asn Asp Gly Lys Pro  His Gln Pro Ile Leu  Lys Val Arg 
    1265                 1270                 1275             


Val Phe  Glu Gln Gly Ser Lys  Phe Pro Leu Gly Glu  Thr Gly Asn 
    1280                 1285                 1290             


Lys Thr  Thr Lys Tyr Val Glu  Ala Ala Lys Gly Thr  Asn Leu Phe 
    1295                 1300                 1305             


Phe Gly  Val Tyr Glu Asp Asn  Gln Gly Lys Arg Ser  Tyr Asp Thr 
    1310                 1315                 1320             


Ile Pro  Leu Asn Ile Val Ile  Glu Arg Gln Lys Gln  Gly Leu Asn 
    1325                 1330                 1335             


Ser Val  Pro Glu Thr Asn Glu  Lys Gly His Arg Leu  Leu Phe Ser 
    1340                 1345                 1350             


Leu Ser  Pro Asn Asp Leu Val  Tyr Val Pro Ile Glu  Gly Glu Val 
    1355                 1360                 1365             


Phe Asp  Glu Thr Asn Pro Asp  Val Asn Arg Ile Tyr  Lys Val Val 
    1370                 1375                 1380             


Ser Phe  Ser Gly Ser Gln Met  Phe Cys Val Arg Gln  Asp Val Ala 
    1385                 1390                 1395             


Thr Ser  Ile Val Tyr Lys Leu  Glu Phe Ser Ser Leu  Asn Lys Met 
    1400                 1405                 1410             


Glu Arg  Thr Ile Asp Gly Ile  Met Ile Lys Glu Ile  Cys Ile Lys 
    1415                 1420                 1425             


Leu Lys  Val Asp Arg Leu Gly  Asn Ile Ser Lys Ala  
    1430                 1435                 1440 


<210> 618
<211> 1409
<212> PRT
<213> Wolinella succinogenes

<400> 618
Met Leu Val Ser Pro Ile Ser Val Asp Leu Gly Gly Lys Asn Thr Gly 
1               5                   10                  15      


Phe Phe Ser Phe Thr Asp Ser Leu Asp Asn Ser Gln Ser Gly Thr Val 
            20                  25                  30          


Ile Tyr Asp Glu Ser Phe Val Leu Ser Gln Val Gly Arg Arg Ser Lys 
        35                  40                  45              


Arg His Ser Lys Arg Asn Asn Leu Arg Asn Lys Leu Val Lys Arg Leu 
    50                  55                  60                  


Phe Leu Leu Ile Leu Gln Glu His His Gly Leu Ser Ile Asp Val Leu 
65                  70                  75                  80  


Pro Asp Glu Ile Arg Gly Leu Phe Asn Lys Arg Gly Tyr Thr Tyr Ala 
                85                  90                  95      


Gly Phe Glu Leu Asp Glu Lys Lys Lys Asp Ala Leu Glu Ser Asp Thr 
            100                 105                 110         


Leu Lys Glu Phe Leu Ser Glu Lys Leu Gln Ser Ile Asp Arg Asp Ser 
        115                 120                 125             


Asp Val Glu Asp Phe Leu Asn Gln Ile Ala Ser Asn Ala Glu Ser Phe 
    130                 135                 140                 


Lys Asp Tyr Lys Lys Gly Phe Glu Ala Val Phe Ala Ser Ala Thr His 
145                 150                 155                 160 


Ser Pro Asn Lys Lys Leu Glu Leu Lys Asp Glu Leu Lys Ser Glu Tyr 
                165                 170                 175     


Gly Glu Asn Ala Lys Glu Leu Leu Ala Gly Leu Arg Val Thr Lys Glu 
            180                 185                 190         


Ile Leu Asp Glu Phe Asp Lys Gln Glu Asn Gln Gly Asn Leu Pro Arg 
        195                 200                 205             


Ala Lys Tyr Phe Glu Glu Leu Gly Glu Tyr Ile Ala Thr Asn Glu Lys 
    210                 215                 220                 


Val Lys Ser Phe Phe Asp Ser Asn Ser Leu Lys Leu Thr Asp Met Thr 
225                 230                 235                 240 


Lys Leu Ile Gly Asn Ile Ser Asn Tyr Gln Leu Lys Glu Leu Arg Arg 
                245                 250                 255     


Tyr Phe Asn Asp Lys Glu Met Glu Lys Gly Asp Ile Trp Ile Pro Asn 
            260                 265                 270         


Lys Leu His Lys Ile Thr Glu Arg Phe Val Arg Ser Trp His Pro Lys 
        275                 280                 285             


Asn Asp Ala Asp Arg Gln Arg Arg Ala Glu Leu Met Lys Asp Leu Lys 
    290                 295                 300                 


Ser Lys Glu Ile Met Glu Leu Leu Thr Thr Thr Glu Pro Val Met Thr 
305                 310                 315                 320 


Ile Pro Pro Tyr Asp Asp Met Asn Asn Arg Gly Ala Val Lys Cys Gln 
                325                 330                 335     


Thr Leu Arg Leu Asn Glu Glu Tyr Leu Asp Lys His Leu Pro Asn Trp 
            340                 345                 350         


Arg Asp Ile Ala Lys Arg Leu Asn His Gly Lys Phe Asn Asp Asp Leu 
        355                 360                 365             


Ala Asp Ser Thr Val Lys Gly Tyr Ser Glu Asp Ser Thr Leu Leu His 
    370                 375                 380                 


Arg Leu Leu Asp Thr Ser Lys Glu Ile Asp Ile Tyr Glu Leu Arg Gly 
385                 390                 395                 400 


Lys Lys Pro Asn Glu Leu Leu Val Lys Thr Leu Gly Gln Ser Asp Ala 
                405                 410                 415     


Asn Arg Leu Tyr Gly Phe Ala Gln Asn Tyr Tyr Glu Leu Ile Arg Gln 
            420                 425                 430         


Lys Val Arg Ala Gly Ile Trp Val Pro Val Lys Asn Lys Asp Asp Ser 
        435                 440                 445             


Leu Asn Leu Glu Asp Asn Ser Asn Met Leu Lys Arg Cys Asn His Asn 
    450                 455                 460                 


Pro Pro His Lys Lys Asn Gln Ile His Asn Leu Val Ala Gly Ile Leu 
465                 470                 475                 480 


Gly Val Lys Leu Asp Glu Ala Lys Phe Ala Glu Phe Glu Lys Glu Leu 
                485                 490                 495     


Trp Ser Ala Lys Val Gly Asn Lys Lys Leu Ser Ala Tyr Cys Lys Asn 
            500                 505                 510         


Ile Glu Glu Leu Arg Lys Thr His Gly Asn Thr Phe Lys Ile Asp Ile 
        515                 520                 525             


Glu Glu Leu Arg Lys Lys Asp Pro Ala Glu Leu Ser Lys Glu Glu Lys 
    530                 535                 540                 


Ala Lys Leu Arg Leu Thr Asp Asp Val Ile Leu Asn Glu Trp Ser Gln 
545                 550                 555                 560 


Lys Ile Ala Asn Phe Phe Asp Ile Asp Asp Lys His Arg Gln Arg Phe 
                565                 570                 575     


Asn Asn Leu Phe Ser Met Ala Gln Leu His Thr Val Ile Asp Thr Pro 
            580                 585                 590         


Arg Ser Gly Phe Ser Ser Thr Cys Lys Arg Cys Thr Ala Glu Asn Arg 
        595                 600                 605             


Phe Arg Ser Glu Thr Ala Phe Tyr Asn Asp Glu Thr Gly Glu Phe His 
    610                 615                 620                 


Lys Lys Ala Thr Ala Thr Cys Gln Arg Leu Pro Ala Asp Thr Gln Arg 
625                 630                 635                 640 


Pro Phe Ser Gly Lys Ile Glu Arg Tyr Ile Asp Lys Leu Gly Tyr Glu 
                645                 650                 655     


Leu Ala Lys Ile Lys Ala Lys Glu Leu Glu Gly Met Glu Ala Lys Glu 
            660                 665                 670         


Ile Lys Val Pro Ile Ile Leu Glu Gln Asn Ala Phe Glu Tyr Glu Glu 
        675                 680                 685             


Ser Leu Arg Lys Ser Lys Thr Gly Ser Asn Asp Arg Val Ile Asn Ser 
    690                 695                 700                 


Lys Lys Asp Arg Asp Gly Lys Lys Leu Ala Lys Ala Lys Glu Asn Ala 
705                 710                 715                 720 


Glu Asp Arg Leu Lys Asp Lys Asp Lys Arg Ile Lys Ala Phe Ser Ser 
                725                 730                 735     


Gly Ile Cys Pro Tyr Cys Gly Asp Thr Ile Gly Asp Asp Gly Glu Ile 
            740                 745                 750         


Asp His Ile Leu Pro Arg Ser His Thr Leu Lys Ile Tyr Gly Thr Val 
        755                 760                 765             


Phe Asn Pro Glu Gly Asn Leu Ile Tyr Val His Gln Lys Cys Asn Gln 
    770                 775                 780                 


Ala Lys Ala Asp Ser Ile Tyr Lys Leu Ser Asp Ile Lys Ala Gly Val 
785                 790                 795                 800 


Ser Ala Gln Trp Ile Glu Glu Gln Val Ala Asn Ile Lys Gly Tyr Lys 
                805                 810                 815     


Thr Phe Ser Val Leu Ser Ala Glu Gln Gln Lys Ala Phe Arg Tyr Ala 
            820                 825                 830         


Leu Phe Leu Gln Asn Asp Asn Glu Ala Tyr Lys Lys Val Val Asp Trp 
        835                 840                 845             


Leu Arg Thr Asp Gln Ser Ala Arg Val Asn Gly Thr Gln Lys Tyr Leu 
    850                 855                 860                 


Ala Lys Lys Ile Gln Glu Lys Leu Thr Lys Met Leu Pro Asn Lys His 
865                 870                 875                 880 


Leu Ser Phe Glu Phe Ile Leu Ala Asp Ala Thr Glu Val Ser Glu Leu 
                885                 890                 895     


Arg Arg Gln Tyr Ala Arg Gln Asn Pro Leu Leu Ala Lys Ala Glu Lys 
            900                 905                 910         


Gln Ala Pro Ser Ser His Ala Ile Asp Ala Val Met Ala Phe Val Ala 
        915                 920                 925             


Arg Tyr Gln Lys Val Phe Lys Asp Gly Thr Pro Pro Asn Ala Asp Glu 
    930                 935                 940                 


Val Ala Lys Leu Ala Met Leu Asp Ser Trp Asn Pro Ala Ser Asn Glu 
945                 950                 955                 960 


Pro Leu Thr Lys Gly Leu Ser Thr Asn Gln Lys Ile Glu Lys Met Ile 
                965                 970                 975     


Lys Ser Gly Asp Tyr Gly Gln Lys Asn Met Arg Glu Val Phe Gly Lys 
            980                 985                 990         


Ser Ile Phe Gly Glu Asn Ala Ile  Gly Glu Arg Tyr Lys  Pro Ile Val 
        995                 1000                 1005             


Val Gln  Glu Gly Gly Tyr Tyr  Ile Gly Tyr Pro Ala  Thr Val Lys 
    1010                 1015                 1020             


Lys Gly  Tyr Glu Leu Lys Asn  Cys Lys Val Val Thr  Ser Lys Asn 
    1025                 1030                 1035             


Asp Ile  Ala Lys Leu Glu Lys  Ile Ile Lys Asn Gln  Asp Leu Ile 
    1040                 1045                 1050             


Ser Leu  Lys Glu Asn Gln Tyr  Ile Lys Ile Phe Ser  Ile Asn Lys 
    1055                 1060                 1065             


Gln Thr  Ile Ser Glu Leu Ser  Asn Arg Tyr Phe Asn  Met Asn Tyr 
    1070                 1075                 1080             


Lys Asn  Leu Val Glu Arg Asp  Lys Glu Ile Val Gly  Leu Leu Glu 
    1085                 1090                 1095             


Phe Ile  Val Glu Asn Cys Arg  Tyr Tyr Thr Lys Lys  Val Asp Val 
    1100                 1105                 1110             


Lys Phe  Ala Pro Lys Tyr Ile  His Glu Thr Lys Tyr  Pro Phe Tyr 
    1115                 1120                 1125             


Asp Asp  Trp Arg Arg Phe Asp  Glu Ala Trp Arg Tyr  Leu Gln Glu 
    1130                 1135                 1140             


Asn Gln  Asn Lys Thr Ser Ser  Lys Asp Arg Phe Val  Ile Asp Lys 
    1145                 1150                 1155             


Ser Ser  Leu Asn Glu Tyr Tyr  Gln Pro Asp Lys Asn  Glu Tyr Lys 
    1160                 1165                 1170             


Leu Asp  Val Asp Thr Gln Pro  Ile Trp Asp Asp Phe  Cys Arg Trp 
    1175                 1180                 1185             


Tyr Phe  Leu Asp Arg Tyr Lys  Thr Ala Asn Asp Lys  Lys Ser Ile 
    1190                 1195                 1200             


Arg Ile  Lys Ala Arg Lys Thr  Phe Ser Leu Leu Ala  Glu Ser Gly 
    1205                 1210                 1215             


Val Gln  Gly Lys Val Phe Arg  Ala Lys Arg Lys Ile  Pro Thr Gly 
    1220                 1225                 1230             


Tyr Ala  Tyr Gln Ala Leu Pro  Met Asp Asn Asn Val  Ile Ala Gly 
    1235                 1240                 1245             


Asp Tyr  Ala Asn Ile Leu Leu  Glu Ala Asn Ser Lys  Thr Leu Ser 
    1250                 1255                 1260             


Leu Val  Pro Lys Ser Gly Ile  Ser Ile Glu Lys Gln  Leu Asp Lys 
    1265                 1270                 1275             


Lys Leu  Asp Val Ile Lys Lys  Thr Asp Val Arg Gly  Leu Ala Ile 
    1280                 1285                 1290             


Asp Asn  Asn Ser Phe Phe Asn  Ala Asp Phe Asp Thr  His Gly Ile 
    1295                 1300                 1305             


Arg Leu  Ile Val Glu Asn Thr  Ser Val Lys Val Gly  Asn Phe Pro 
    1310                 1315                 1320             


Ile Ser  Ala Ile Asp Lys Ser  Ala Lys Arg Met Ile  Phe Arg Ala 
    1325                 1330                 1335             


Leu Phe  Glu Lys Glu Lys Gly  Lys Arg Lys Lys Lys  Thr Thr Ile 
    1340                 1345                 1350             


Ser Phe  Lys Glu Ser Gly Pro  Val Gln Asp Tyr Leu  Lys Val Phe 
    1355                 1360                 1365             


Leu Lys  Lys Ile Val Lys Ile  Gln Leu Arg Thr Asp  Gly Ser Ile 
    1370                 1375                 1380             


Ser Asn  Ile Val Val Arg Lys  Asn Ala Ala Asp Phe  Thr Leu Ser 
    1385                 1390                 1395             


Phe Arg  Ser Glu His Ile Gln  Lys Leu Leu Lys 
    1400                 1405                 


<210> 619
<211> 1059
<212> PRT
<213> Wolinella succinogenes

<400> 619
Met Ile Glu Arg Ile Leu Gly Val Asp Leu Gly Ile Ser Ser Leu Gly 
1               5                   10                  15      


Trp Ala Ile Val Glu Tyr Asp Lys Asp Asp Glu Ala Ala Asn Arg Ile 
            20                  25                  30          


Ile Asp Cys Gly Val Arg Leu Phe Thr Ala Ala Glu Thr Pro Lys Lys 
        35                  40                  45              


Lys Glu Ser Pro Asn Lys Ala Arg Arg Glu Ala Arg Gly Ile Arg Arg 
    50                  55                  60                  


Val Leu Asn Arg Arg Arg Val Arg Met Asn Met Ile Lys Lys Leu Phe 
65                  70                  75                  80  


Leu Arg Ala Gly Leu Ile Gln Asp Val Asp Leu Asp Gly Glu Gly Gly 
                85                  90                  95      


Met Phe Tyr Ser Lys Ala Asn Arg Ala Asp Val Trp Glu Leu Arg His 
            100                 105                 110         


Asp Gly Leu Tyr Arg Leu Leu Lys Gly Asp Glu Leu Ala Arg Val Leu 
        115                 120                 125             


Ile His Ile Ala Lys His Arg Gly Tyr Lys Phe Ile Gly Asp Asp Glu 
    130                 135                 140                 


Ala Asp Glu Glu Ser Gly Lys Val Lys Lys Ala Gly Val Val Leu Arg 
145                 150                 155                 160 


Gln Asn Phe Glu Ala Ala Gly Cys Arg Thr Val Gly Glu Trp Leu Trp 
                165                 170                 175     


Arg Glu Arg Gly Ala Asn Gly Lys Lys Arg Asn Lys His Gly Asp Tyr 
            180                 185                 190         


Glu Ile Ser Ile His Arg Asp Leu Leu Val Glu Glu Val Glu Ala Ile 
        195                 200                 205             


Phe Val Ala Gln Gln Glu Met Arg Ser Thr Ile Ala Thr Asp Ala Leu 
    210                 215                 220                 


Lys Ala Ala Tyr Arg Glu Ile Ala Phe Phe Val Arg Pro Met Gln Arg 
225                 230                 235                 240 


Ile Glu Lys Met Val Gly His Cys Thr Tyr Phe Pro Glu Glu Arg Arg 
                245                 250                 255     


Ala Pro Lys Ser Ala Pro Thr Ala Glu Lys Phe Ile Ala Ile Ser Lys 
            260                 265                 270         


Phe Phe Ser Thr Val Ile Ile Asp Asn Glu Gly Trp Glu Gln Lys Ile 
        275                 280                 285             


Ile Glu Arg Lys Thr Leu Glu Glu Leu Leu Asp Phe Ala Val Ser Arg 
    290                 295                 300                 


Glu Lys Val Glu Phe Arg His Leu Arg Lys Phe Leu Asp Leu Ser Asp 
305                 310                 315                 320 


Asn Glu Ile Phe Lys Gly Leu His Tyr Lys Gly Lys Pro Lys Thr Ala 
                325                 330                 335     


Lys Lys Arg Glu Ala Thr Leu Phe Asp Pro Asn Glu Pro Thr Glu Leu 
            340                 345                 350         


Glu Phe Asp Lys Val Glu Ala Glu Lys Lys Ala Trp Ile Ser Leu Arg 
        355                 360                 365             


Gly Ala Ala Lys Leu Arg Glu Ala Leu Gly Asn Glu Phe Tyr Gly Arg 
    370                 375                 380                 


Phe Val Ala Leu Gly Lys His Ala Asp Glu Ala Thr Lys Ile Leu Thr 
385                 390                 395                 400 


Tyr Tyr Lys Asp Glu Gly Gln Lys Arg Arg Glu Leu Thr Lys Leu Pro 
                405                 410                 415     


Leu Glu Ala Glu Met Val Glu Arg Leu Val Lys Ile Gly Phe Ser Asp 
            420                 425                 430         


Phe Leu Lys Leu Ser Leu Lys Ala Ile Arg Asp Ile Leu Pro Ala Met 
        435                 440                 445             


Glu Ser Gly Ala Arg Tyr Asp Glu Ala Val Leu Met Leu Gly Val Pro 
    450                 455                 460                 


His Lys Glu Lys Ser Ala Ile Leu Pro Pro Leu Asn Lys Thr Asp Ile 
465                 470                 475                 480 


Asp Ile Leu Asn Pro Thr Val Ile Arg Ala Phe Ala Gln Phe Arg Lys 
                485                 490                 495     


Val Ala Asn Ala Leu Val Arg Lys Tyr Gly Ala Phe Asp Arg Val His 
            500                 505                 510         


Phe Glu Leu Ala Arg Glu Ile Asn Thr Lys Gly Glu Ile Glu Asp Ile 
        515                 520                 525             


Lys Glu Ser Gln Arg Lys Asn Glu Lys Glu Arg Lys Glu Ala Ala Asp 
    530                 535                 540                 


Trp Ile Ala Glu Thr Ser Phe Gln Val Pro Leu Thr Arg Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Arg Leu Tyr Ile Gln Gln Asp Gly Arg Cys Ala Tyr Thr 
                565                 570                 575     


Gly Asp Val Ile Glu Leu Glu Arg Leu Phe Asp Glu Gly Tyr Cys Glu 
            580                 585                 590         


Ile Asp His Ile Leu Pro Arg Ser Arg Ser Ala Asp Asp Ser Phe Ala 
        595                 600                 605             


Asn Lys Val Leu Cys Leu Ala Arg Ala Asn Gln Gln Lys Thr Asp Arg 
    610                 615                 620                 


Thr Pro Tyr Glu Trp Phe Gly His Asp Ala Ala Arg Trp Asn Ala Phe 
625                 630                 635                 640 


Glu Thr Arg Thr Ser Ala Pro Ser Asn Arg Val Arg Thr Gly Lys Gly 
                645                 650                 655     


Lys Ile Asp Arg Leu Leu Lys Lys Asn Phe Asp Glu Asn Ser Glu Met 
            660                 665                 670         


Ala Phe Lys Asp Arg Asn Leu Asn Asp Thr Arg Tyr Met Ala Arg Ala 
        675                 680                 685             


Ile Lys Thr Tyr Cys Glu Gln Tyr Trp Val Phe Lys Asn Ser His Thr 
    690                 695                 700                 


Lys Ala Pro Val Gln Val Arg Ser Gly Lys Leu Thr Ser Val Leu Arg 
705                 710                 715                 720 


Tyr Gln Trp Gly Leu Glu Ser Lys Asp Arg Glu Ser His Thr His His 
                725                 730                 735     


Ala Val Asp Ala Ile Ile Ile Ala Phe Ser Thr Gln Gly Met Val Gln 
            740                 745                 750         


Lys Leu Ser Glu Tyr Tyr Arg Phe Lys Glu Thr His Arg Glu Lys Glu 
        755                 760                 765             


Arg Pro Lys Leu Ala Val Pro Leu Ala Asn Phe Arg Asp Ala Val Glu 
    770                 775                 780                 


Glu Ala Thr Arg Ile Glu Asn Thr Glu Thr Val Lys Glu Gly Val Glu 
785                 790                 795                 800 


Val Lys Arg Leu Leu Ile Ser Arg Pro Pro Arg Ala Arg Val Thr Gly 
                805                 810                 815     


Gln Ala His Glu Gln Thr Ala Lys Pro Tyr Pro Arg Ile Lys Gln Val 
            820                 825                 830         


Lys Asn Lys Lys Lys Trp Arg Leu Ala Pro Ile Asp Glu Glu Lys Phe 
        835                 840                 845             


Glu Ser Phe Lys Ala Asp Arg Val Ala Ser Ala Asn Gln Lys Asn Phe 
    850                 855                 860                 


Tyr Glu Thr Ser Thr Ile Pro Arg Val Asp Val Tyr His Lys Lys Gly 
865                 870                 875                 880 


Lys Phe His Leu Val Pro Ile Tyr Leu His Glu Met Val Leu Asn Glu 
                885                 890                 895     


Leu Pro Asn Leu Ser Leu Gly Thr Asn Pro Glu Ala Met Asp Glu Asn 
            900                 905                 910         


Phe Phe Lys Phe Ser Ile Phe Lys Asp Asp Leu Ile Ser Ile Gln Thr 
        915                 920                 925             


Gln Gly Thr Pro Lys Lys Pro Ala Lys Ile Ile Met Gly Tyr Phe Lys 
    930                 935                 940                 


Asn Met His Gly Ala Asn Met Val Leu Ser Ser Ile Asn Asn Ser Pro 
945                 950                 955                 960 


Cys Glu Gly Phe Thr Cys Thr Pro Val Ser Met Asp Lys Lys His Lys 
                965                 970                 975     


Asp Lys Cys Lys Leu Cys Pro Glu Glu Asn Arg Ile Ala Gly Arg Cys 
            980                 985                 990         


Leu Gln Gly Phe Leu Asp Tyr Trp  Ser Gln Glu Gly Leu  Arg Pro Pro 
        995                 1000                 1005             


Arg Lys  Glu Phe Glu Cys Asp  Gln Gly Val Lys Phe  Ala Leu Asp 
    1010                 1015                 1020             


Val Lys  Lys Tyr Gln Ile Asp  Pro Leu Gly Tyr Tyr  Tyr Glu Val 
    1025                 1030                 1035             


Lys Gln  Glu Lys Arg Leu Gly  Thr Ile Pro Gln Met  Arg Ser Ala 
    1040                 1045                 1050             


Lys Lys  Leu Val Lys Lys 
    1055                 


<210> 620
<211> 1388
<212> PRT
<213> Zunongwangia profunda

<400> 620
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Glu Asn Glu Lys Glu Ile Ser Lys Ile Ile 
            20                  25                  30          


Lys Leu Gly Val Arg Val Asn Pro Leu Thr Ile Asp Glu Lys Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Arg Pro Leu Ser Thr Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Ala Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Glu Asn 
65                  70                  75                  80  


Leu Ile Glu Ile Leu Ile Asp Asn His Ile Ile Thr Lys Glu Thr Pro 
                85                  90                  95      


Leu Thr Glu Ile Gly Lys Gly Thr Thr Tyr Gln Thr Leu Ser Leu Arg 
            100                 105                 110         


Ala Lys Ala Val Arg Glu Arg Ile Asp Leu Glu Asp Phe Ala Lys Val 
        115                 120                 125             


Leu Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Ser Asn Asp Glu Glu Gly Gln Ala Ile Asp Gly Met Ala Ile Ala Lys 
145                 150                 155                 160 


Glu Leu Tyr Glu Arg Gly Ile Thr Pro Gly Gln Tyr Val Leu Glu Leu 
                165                 170                 175     


Leu Glu Asn Asp Arg Lys Tyr Ile Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Lys Gln Glu Phe Asn Lys Ile Trp Asn Asn Gln Lys Thr Phe Tyr Pro 
        195                 200                 205             


Glu Ile Leu Thr Asp Glu Leu Phe Lys Glu Leu Asp Gly Lys Asn Lys 
    210                 215                 220                 


Ser Gln Thr Trp Ala Ile Cys Gln Lys Pro Phe Asn Ile Lys Gly Ile 
225                 230                 235                 240 


Lys Arg Ile Thr Lys Gly Arg Glu Lys Thr Ile Glu Asn Tyr His Trp 
                245                 250                 255     


Arg Val Lys Gly Leu Ser Gly Lys Leu Asn Leu Glu Lys Leu Ala Ile 
            260                 265                 270         


Ile Leu Gln Glu Ile Asn Asn Asp Ile Asn Gln Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Gly Ile Ser Asp Lys Ser Lys Lys Leu Tyr Leu Asn Lys Glu Thr 
    290                 295                 300                 


Val Gly Glu Phe Leu Tyr Lys Gln Ile Ala Lys Asn Pro His Thr Ser 
305                 310                 315                 320 


Leu Lys Asn Gln Val Phe Tyr Arg His Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Gln Ile Trp Lys Thr Gln Ser Asn Phe Asn Ala Asn Leu Thr Asp Glu 
            340                 345                 350         


Leu Lys Gln Glu Ile Arg Asp Val Ile Ile Phe Tyr Gln Arg Lys Ile 
        355                 360                 365             


Lys Ser Gln Lys Ser Leu Ile Ser Phe Cys Gln Phe Glu Ser Trp Glu 
    370                 375                 380                 


Gln Glu Tyr Phe Asp Lys Glu Thr Gly Lys Thr Lys Thr Arg Thr Val 
385                 390                 395                 400 


Gly Arg Arg Val Ile Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys 
                405                 410                 415     


Ile Trp Gln Asn Leu Asn His Leu Val Phe Thr Asn Ser Glu Thr Asp 
            420                 425                 430         


Glu Lys Ile Glu Ile Lys Glu Val Glu Gln Glu Ile Arg Lys Glu Leu 
        435                 440                 445             


Phe Glu Glu Leu Asn Leu Arg Gly Asp Leu Asn Pro Asn Asp Leu Leu 
    450                 455                 460                 


Lys Ile Leu Arg Ser Gln Phe Lys Ile Gly Lys Leu Ser Asn Trp Lys 
465                 470                 475                 480 


Cys Asn Phe Glu Lys Ile Glu Gly Asn Arg Thr Asn Ala Ala Leu Phe 
                485                 490                 495     


Asn Ile Tyr Gln Lys Ile Ser Asp Phe Glu Gly Tyr Gly Ile Asp Trp 
            500                 505                 510         


Asn Lys Ser Asn Ala Lys Lys Ile Arg Lys Glu Leu Lys Ala Thr Phe 
        515                 520                 525             


Pro Glu Ile Gly Ile Asp Ala Ser Ile Leu Glu Phe Asp Ala Tyr Lys 
    530                 535                 540                 


Lys Gln Leu Thr Asn Gln Ser Ser Tyr Glu Leu Trp His Leu Leu Tyr 
545                 550                 555                 560 


Ser Ala Glu Glu Asp Phe Lys Ile Ser Glu Gln Asp Lys Leu Ile Tyr 
                565                 570                 575     


Gly Asn Ser Ser Val Ser Leu Lys Lys Lys Leu His Leu Lys Phe Gly 
            580                 585                 590         


Phe Asn Pro Glu Tyr Ala Lys Met Leu Ala Asn Leu Ser Leu Met Ser 
        595                 600                 605             


Asp Tyr Gly Asn Leu Ser Ala Lys Ala Ile Lys Lys Ile Leu Pro Tyr 
    610                 615                 620                 


Leu Glu Asp Gly His Leu Tyr Ser Glu Ala Cys Arg Leu Ala Gly Tyr 
625                 630                 635                 640 


Asn His Ser Lys Ser Leu Thr Ala Glu Glu Leu Glu Lys Phe Glu Pro 
                645                 650                 655     


Lys Ala Lys Leu Asp Leu Leu Lys Lys Asn Ser Leu Arg Asn Pro Val 
            660                 665                 670         


Val Glu Lys Ile Leu Asn Gln Met Val Asn Val Val Asn Gln Val Ile 
        675                 680                 685             


Asp Thr Tyr Gly Lys Pro Asp Gly Val Arg Ile Glu Leu Ala Arg Glu 
    690                 695                 700                 


Leu Lys Lys Ser Ala Lys Glu Arg Ala Glu Met Thr Lys Gly Ile Ala 
705                 710                 715                 720 


Asp Gly Thr Arg Arg Asn Glu Glu Ile Lys Lys Ile Ile Thr Gln Lys 
                725                 730                 735     


Phe Gly Ile Pro Asn Pro Thr Lys Ser Asp Leu Val Arg Tyr Arg Leu 
            740                 745                 750         


Trp Gln Glu Leu Glu Ser Arg Gly Tyr Lys Asp Ile Phe Thr Asp Lys 
        755                 760                 765             


Tyr Ile Ser Pro Asp Lys Ile Phe Ser Ser Glu Ile Asp Ile Glu His 
    770                 775                 780                 


Ile Ile Pro Lys Ala Leu Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr 
785                 790                 795                 800 


Leu Ser Phe Arg Asn Val Asn Leu Lys Lys Ala Asn Arg Thr Ala Leu 
                805                 810                 815     


Asp Phe Ile Thr Gln Asp Tyr Gln Ser Asn Val Glu Ala Tyr Lys Glu 
            820                 825                 830         


Arg Val Glu Thr Trp Asn Lys Asp Asn His Ile Ser Lys Gly Lys Arg 
        835                 840                 845             


Asn Lys Leu Leu Met Ser Leu Lys Asp Ile Pro Asp Gly Phe Ile Glu 
    850                 855                 860                 


Arg Asp Leu Arg Asn Ser Gln Tyr Ile Ala Arg Lys Ala Lys Arg Met 
865                 870                 875                 880 


Leu Tyr Glu Val Phe Pro Asn Glu Val Leu Ala Thr Ser Gly Ser Ile 
                885                 890                 895     


Thr Asp Lys Leu Arg Ser Asp Trp Asp Leu Ile Asn Val Met Lys Glu 
            900                 905                 910         


Leu Asn Leu Pro Lys Tyr Lys Ala Leu Gly Leu Thr Glu Tyr Glu Glu 
        915                 920                 925             


Arg Leu Asp Lys Gly Thr Glu Glu Leu Phe Lys His Glu Val Ile Lys 
    930                 935                 940                 


Asp Trp Thr Lys Arg Asn Asp His Arg His His Ala Met Asp Ala Leu 
945                 950                 955                 960 


Ala Val Ala Phe Thr Thr His Asn His Ile Gln Tyr Ile Asn Asn Leu 
                965                 970                 975     


Asn Ala Arg Lys Asp Ile Thr Gln Asp Asn His Pro Ile Ile Lys Asn 
            980                 985                 990         


Ile Glu Asn Leu Ile Thr Glu Val  Asn Ser Lys Gly Lys  Arg Val Phe 
        995                 1000                 1005             


Lys Ala  Pro Met Ser Ser Phe  Arg Glu Ser Ala Lys  Glu Gln Ile 
    1010                 1015                 1020             


Glu Ala  Ile Leu Val Ser Phe  Lys Asn Lys Asn Lys  Val Val Thr 
    1025                 1030                 1035             


Lys Asn  Ile Asn Gln Thr Lys  Lys Glu Gly Gly Phe  Asn Tyr Gln 
    1040                 1045                 1050             


Asn Ala  Lys Thr Pro Arg Gly  Gln Leu His Lys Glu  Thr Ile Tyr 
    1055                 1060                 1065             


Gly Lys  Ser Lys Gln Pro Leu  Glu Lys Pro Val Lys  Ile Asn Asn 
    1070                 1075                 1080             


Arg Phe  Cys Lys Lys Gln Val  Gly Leu Ile Ile Asn  Phe Lys Glu 
    1085                 1090                 1095             


Gln Glu  Ala Val Leu His His  Leu Lys Lys Tyr Asp  Asn Asn Glu 
    1100                 1105                 1110             


Lys Ile  Ala Phe Ser Asn Lys  Thr Leu Lys Ser Asp  Pro Ile Gln 
    1115                 1120                 1125             


Val Asn  Gly Ser Pro Leu Arg  Glu Val Lys Ile Phe  Glu Glu Ile 
    1130                 1135                 1140             


Phe Thr  Ile Arg Lys Asp Ile  Asn Pro Asp Asn Phe  Lys Thr Gln 
    1145                 1150                 1155             


Lys His  Leu Asp Lys Ile Ile  Asp Lys Gly Ile Lys  Glu Val Met 
    1160                 1165                 1170             


Lys Lys  Arg Leu Glu Glu Tyr  Asn Gly Asp Phe Lys  Thr Ala Phe 
    1175                 1180                 1185             


Ser Asp  Leu Asp Lys Asn Pro  Ile Trp Leu Asn Gln  Ser Lys Gly 
    1190                 1195                 1200             


Ile Thr  Ile Lys Arg Ala Thr  Ile Ser Gly Val Thr  Asn Ala Glu 
    1205                 1210                 1215             


Pro Leu  His Gln Ala Lys Asp  His Leu Gly Asn Ile  Ile Leu Asp 
    1220                 1225                 1230             


Asp Asn  Gly Lys Glu Ile Pro  Ile Asp Tyr Val Ser  Thr Gly Asn 
    1235                 1240                 1245             


Asn His  His Val Ala Ile Tyr  Gln Asp Glu Ser Gly  Asn Leu Gln 
    1250                 1255                 1260             


Glu Glu  Val Val Ser Phe Tyr  Glu Ala Val Ile Arg  Lys Asn Gln 
    1265                 1270                 1275             


Asp Gln  Pro Ile Ile Lys Lys  Arg His Pro Lys Gly  Trp Lys Phe 
    1280                 1285                 1290             


Leu Phe  Thr Met Lys Gln Asn  Glu Met Phe Val Phe  Ser Ser Glu 
    1295                 1300                 1305             


Asn Phe  Asn Pro Ser Glu Ile  Asp Leu Leu Asp Glu  Lys Asn Ala 
    1310                 1315                 1320             


Ala Ile  Ile Ser Pro Asn Leu  Phe Arg Val Gln Lys  Ile Ala Thr 
    1325                 1330                 1335             


Lys Asn  Tyr Met Phe Arg His  His Leu Glu Thr Glu  Val Thr Asn 
    1340                 1345                 1350             


Asn Leu  Asp Phe Thr Tyr Arg  His Phe Gln Ala Thr  Glu Trp Leu 
    1355                 1360                 1365             


Arg Asn  Leu Cys Lys Val Arg  Ile Asp His Ile Gly  Arg Ile Val 
    1370                 1375                 1380             


Gln Ile  Gly Glu Tyr 
    1385             


<210> 621

<400> 621
000


<210> 622

<400> 622
000


<210> 623

<400> 623
000


<210> 624

<400> 624
000


<210> 625

<400> 625
000


<210> 626

<400> 626
000


<210> 627

<400> 627
000


<210> 628

<400> 628
000


<210> 629

<400> 629
000


<210> 630

<400> 630
000


<210> 631

<400> 631
000


<210> 632
<211> 22
<212> RNA
<213> Homo sapiens

<400> 632
ugcucagguu gcacagcugg ga                                                22


<210> 633
<211> 22
<212> RNA
<213> Homo sapiens

<400> 633
ucccagcugu gcaaccugag ca                                                22


<210> 634
<211> 22
<212> RNA
<213> Homo sapiens

<400> 634
ucaggugugg aaacugaggc ag                                                22


<210> 635
<211> 22
<212> RNA
<213> Homo sapiens

<400> 635
cugccucagu uuccacaccu ga                                                22


<210> 636
<211> 22
<212> RNA
<213> Homo sapiens

<400> 636
caaaaccgcg auuacucuug ca                                                22


<210> 637
<211> 22
<212> RNA
<213> Homo sapiens

<400> 637
ugcaagagua aucgcgguuu ug                                                22


<210> 638
<211> 21
<212> RNA
<213> Homo sapiens

<400> 638
aaaaguaauu gugguuuuug c                                                 21


<210> 639
<211> 21
<212> RNA
<213> Homo sapiens

<400> 639
gcaaaaacca caauuacuuu u                                                 21


<210> 640
<211> 21
<212> RNA
<213> Homo sapiens

<400> 640
aaaaacugca aucacuuuug c                                                 21


<210> 641
<211> 21
<212> RNA
<213> Homo sapiens

<400> 641
gcaaaaguga uugcaguuuu u                                                 21


<210> 642
<211> 22
<212> RNA
<213> Homo sapiens

<400> 642
caaaagugau ugugguuuuu gc                                                22


<210> 643
<211> 22
<212> RNA
<213> Homo sapiens

<400> 643
gcaaaaacca caaucacuuu ug                                                22


<210> 644
<211> 22
<212> RNA
<213> Homo sapiens

<400> 644
agcaguguuu guuuugccca ca                                                22


<210> 645
<211> 22
<212> RNA
<213> Homo sapiens

<400> 645
ugugggcaaa acaaacacug cu                                                22


<210> 646
<211> 22
<212> RNA
<213> Homo sapiens

<400> 646
ucgggcgcaa gagcacugca gu                                                22


<210> 647
<211> 22
<212> RNA
<213> Homo sapiens

<400> 647
acugcagugc ucuugcgccc ga                                                22


<210> 648
<211> 21
<212> RNA
<213> Homo sapiens

<400> 648
acacuuguug ggaugaccug c                                                 21


<210> 649
<211> 21
<212> RNA
<213> Homo sapiens

<400> 649
gcaggucauc ccaacaagug u                                                 21


<210> 650
<211> 24
<212> RNA
<213> Homo sapiens

<400> 650
aggagcuauc cacuccaggu gucc                                              24


<210> 651
<211> 24
<212> RNA
<213> Homo sapiens

<400> 651
ggacaccugg aguggauagc uccu                                              24


<210> 652
<211> 23
<212> RNA
<213> Homo sapiens

<400> 652
ccagagcagc cugcgguaac agu                                               23


<210> 653
<211> 23
<212> RNA
<213> Homo sapiens

<400> 653
acuguuaccg caggcugcuc ugg                                               23


<210> 654
<211> 22
<212> RNA
<213> Homo sapiens

<400> 654
aguugccagg gcugccuuug gu                                                22


<210> 655
<211> 22
<212> RNA
<213> Homo sapiens

<400> 655
accaaaggca gcccuggcaa cu                                                22


<210> 656
<211> 21
<212> RNA
<213> Homo sapiens

<400> 656
uagaccaucu uucuagagua u                                                 21


<210> 657
<211> 21
<212> RNA
<213> Homo sapiens

<400> 657
auacucuaga aagauggucu a                                                 21


<210> 658
<211> 22
<212> RNA
<213> Homo sapiens

<400> 658
agcucuagaa agauuguuga cc                                                22


<210> 659
<211> 22
<212> RNA
<213> Homo sapiens

<400> 659
ggucaacaau cuuucuagag cu                                                22


<210> 660
<211> 21
<212> RNA
<213> Homo sapiens

<400> 660
gggacuagga ugcagaccuc c                                                 21


<210> 661
<211> 21
<212> RNA
<213> Homo sapiens

<400> 661
ggaggucugc auccuagucc c                                                 21


<210> 662
<211> 23
<212> RNA
<213> Homo sapiens

<400> 662
aggucugcau ucaaaucccc aga                                               23


<210> 663
<211> 23
<212> RNA
<213> Homo sapiens

<400> 663
ucuggggauu ugaaugcaga ccu                                               23


<210> 664
<211> 20
<212> RNA
<213> Homo sapiens

<400> 664
cauuacagca cagccauucu                                                   20


<210> 665
<211> 20
<212> RNA
<213> Homo sapiens

<400> 665
agaauggcug ugcuguaaug                                                   20


<210> 666
<211> 21
<212> RNA
<213> Homo sapiens

<400> 666
ucuggcugug cuguaaugca g                                                 21


<210> 667
<211> 21
<212> RNA
<213> Homo sapiens

<400> 667
cugcauuaca gcacagccag a                                                 21


<210> 668
<211> 21
<212> RNA
<213> Homo sapiens

<400> 668
ugacuucuac cucuuccaaa g                                                 21


<210> 669
<211> 21
<212> RNA
<213> Homo sapiens

<400> 669
cuuuggaaga gguagaaguc a                                                 21


<210> 670
<211> 22
<212> RNA
<213> Homo sapiens

<400> 670
uuggaauagg ggauaucuca gc                                                22


<210> 671
<211> 22
<212> RNA
<213> Homo sapiens

<400> 671
gcugagauau ccccuauucc aa                                                22


<210> 672
<211> 22
<212> RNA
<213> Homo sapiens

<400> 672
ucguaucaga gauuccagac ac                                                22


<210> 673
<211> 22
<212> RNA
<213> Homo sapiens

<400> 673
gugucuggaa ucucugauac ga                                                22


<210> 674
<211> 23
<212> RNA
<213> Homo sapiens

<400> 674
acugggaugu cacugaauau ggu                                               23


<210> 675
<211> 23
<212> RNA
<213> Homo sapiens

<400> 675
accauauuca gugacauccc agu                                               23


<210> 676
<211> 22
<212> RNA
<213> Homo sapiens

<400> 676
caaaguccuu ccuauuuuuc cc                                                22


<210> 677
<211> 22
<212> RNA
<213> Homo sapiens

<400> 677
gggaaaaaua ggaaggacuu ug                                                22


<210> 678
<211> 21
<212> RNA
<213> Homo sapiens

<400> 678
gaagaauagg agggacuuug u                                                 21


<210> 679
<211> 21
<212> RNA
<213> Homo sapiens

<400> 679
acaaaguccc uccuauucuu c                                                 21


<210> 680
<211> 22
<212> RNA
<213> Homo sapiens

<400> 680
ugggccaugc auuucuagaa cu                                                22


<210> 681
<211> 22
<212> RNA
<213> Homo sapiens

<400> 681
aguucuagaa augcauggcc ca                                                22


<210> 682
<211> 21
<212> RNA
<213> Homo sapiens

<400> 682
ucuagaaaug caugacccac c                                                 21


<210> 683
<211> 21
<212> RNA
<213> Homo sapiens

<400> 683
ggugggucau gcauuucuag a                                                 21


<210> 684
<211> 22
<212> RNA
<213> Homo sapiens

<400> 684
uuccacugcc acuaccuaau uu                                                22


<210> 685
<211> 22
<212> RNA
<213> Homo sapiens

<400> 685
aaauuaggua guggcagugg aa                                                22


<210> 686
<211> 21
<212> RNA
<213> Homo sapiens

<400> 686
auuagguagu ggcaguggaa c                                                 21


<210> 687
<211> 21
<212> RNA
<213> Homo sapiens

<400> 687
guuccacugc cacuaccuaa u                                                 21


<210> 688
<211> 21
<212> RNA
<213> Homo sapiens

<400> 688
caccgacucu gucuccugca g                                                 21


<210> 689
<211> 21
<212> RNA
<213> Homo sapiens

<400> 689
cugcaggaga cagagucggu g                                                 21


<210> 690
<211> 22
<212> RNA
<213> Homo sapiens

<400> 690
cagcagggga gagagaggag uc                                                22


<210> 691
<211> 22
<212> RNA
<213> Homo sapiens

<400> 691
gacuccucuc ucuccccugc ug                                                22


<210> 692
<211> 22
<212> RNA
<213> Homo sapiens

<400> 692
uuccagcccu ucuaauggua gg                                                22


<210> 693
<211> 22
<212> RNA
<213> Homo sapiens

<400> 693
ccuaccauua gaagggcugg aa                                                22


<210> 694
<211> 22
<212> RNA
<213> Homo sapiens

<400> 694
uaccauuaga agagcuggaa ga                                                22


<210> 695
<211> 22
<212> RNA
<213> Homo sapiens

<400> 695
ucuuccagcu cuucuaaugg ua                                                22


<210> 696
<211> 21
<212> RNA
<213> Homo sapiens

<400> 696
ucaaguguca ucugucccua g                                                 21


<210> 697
<211> 21
<212> RNA
<213> Homo sapiens

<400> 697
cuagggacag augacacuug a                                                 21


<210> 698
<211> 23
<212> RNA
<213> Homo sapiens

<400> 698
uuugggauug acgccacaug ucu                                               23


<210> 699
<211> 23
<212> RNA
<213> Homo sapiens

<400> 699
agacaugugg cgucaauccc aaa                                               23


<210> 700
<211> 21
<212> RNA
<213> Homo sapiens

<400> 700
cugccuguuc uuccacucca g                                                 21


<210> 701
<211> 21
<212> RNA
<213> Homo sapiens

<400> 701
cuggagugga agaacaggca g                                                 21


<210> 702
<211> 23
<212> RNA
<213> Homo sapiens

<400> 702
uauggagugg acuuucagcu ggc                                               23


<210> 703
<211> 23
<212> RNA
<213> Homo sapiens

<400> 703
gccagcugaa aguccacucc aua                                               23


<210> 704
<211> 22
<212> RNA
<213> Homo sapiens

<400> 704
ccucaccauc ccuucugccu gc                                                22


<210> 705
<211> 22
<212> RNA
<213> Homo sapiens

<400> 705
gcaggcagaa gggaugguga gg                                                22


<210> 706
<211> 23
<212> RNA
<213> Homo sapiens

<400> 706
caggcagaag uggggcugac agg                                               23


<210> 707
<211> 23
<212> RNA
<213> Homo sapiens

<400> 707
ccugucagcc ccacuucugc cug                                               23


<210> 708
<211> 20
<212> RNA
<213> Homo sapiens

<400> 708
ucucuucauc uaccccccag                                                   20


<210> 709
<211> 20
<212> RNA
<213> Homo sapiens

<400> 709
cuggggggua gaugaagaga                                                   20


<210> 710
<211> 21
<212> RNA
<213> Homo sapiens

<400> 710
uuggagggug uggaagacau c                                                 21


<210> 711
<211> 21
<212> RNA
<213> Homo sapiens

<400> 711
gaugucuucc acacccucca a                                                 21


<210> 712
<211> 22
<212> RNA
<213> Homo sapiens

<400> 712
cugccagccc cguuccaggg ca                                                22


<210> 713
<211> 22
<212> RNA
<213> Homo sapiens

<400> 713
ugcccuggaa cggggcuggc ag                                                22


<210> 714
<211> 23
<212> RNA
<213> Homo sapiens

<400> 714
acaaaguaca gcauuagccu uag                                               23


<210> 715
<211> 23
<212> RNA
<213> Homo sapiens

<400> 715
cuaaggcuaa ugcuguacuu ugu                                               23


<210> 716
<211> 23
<212> RNA
<213> Homo sapiens

<400> 716
aaaggucauu guaagguuaa ugc                                               23


<210> 717
<211> 23
<212> RNA
<213> Homo sapiens

<400> 717
gcauuaaccu uacaaugacc uuu                                               23


<210> 718
<211> 22
<212> RNA
<213> Homo sapiens

<400> 718
ugaggcuaau gcacuacuuc ac                                                22


<210> 719
<211> 22
<212> RNA
<213> Homo sapiens

<400> 719
gugaaguagu gcauuagccu ca                                                22


<210> 720
<211> 24
<212> RNA
<213> Homo sapiens

<400> 720
uauagagagc aggaagauua augu                                              24


<210> 721
<211> 24
<212> RNA
<213> Homo sapiens

<400> 721
acauuaaucu uccugcucuc uaua                                              24


<210> 722
<211> 23
<212> RNA
<213> Homo sapiens

<400> 722
gugcuucauc guaauuaacc uua                                               23


<210> 723
<211> 23
<212> RNA
<213> Homo sapiens

<400> 723
uaagguuaau uacgaugaag cac                                               23


<210> 724
<211> 24
<212> RNA
<213> Homo sapiens

<400> 724
guggaaagca ugcauccagg gugu                                              24


<210> 725
<211> 24
<212> RNA
<213> Homo sapiens

<400> 725
acacccugga ugcaugcuuu ccac                                              24


<210> 726
<211> 22
<212> RNA
<213> Homo sapiens

<400> 726
agacacauuu ggagagggaa cc                                                22


<210> 727
<211> 22
<212> RNA
<213> Homo sapiens

<400> 727
gguucccucu ccaaaugugu cu                                                22


<210> 728
<211> 22
<212> RNA
<213> Homo sapiens

<400> 728
uucccuuugu cauccuaugc cu                                                22


<210> 729
<211> 22
<212> RNA
<213> Homo sapiens

<400> 729
aggcauagga ugacaaaggg aa                                                22


<210> 730
<211> 21
<212> RNA
<213> Homo sapiens

<400> 730
gcugggaagg caaagggacg u                                                 21


<210> 731
<211> 21
<212> RNA
<213> Homo sapiens

<400> 731
acgucccuuu gccuucccag c                                                 21


<210> 732
<211> 21
<212> RNA
<213> Homo sapiens

<400> 732
uaccacaggg uagaaccacg g                                                 21


<210> 733
<211> 21
<212> RNA
<213> Homo sapiens

<400> 733
ccgugguucu acccuguggu a                                                 21


<210> 734
<211> 22
<212> RNA
<213> Homo sapiens

<400> 734
ggcuggagcg agugcagugg ug                                                22


<210> 735
<211> 22
<212> RNA
<213> Homo sapiens

<400> 735
caccacugca cucgcuccag cc                                                22


<210> 736
<211> 18
<212> RNA
<213> Homo sapiens

<400> 736
ccaggcucug caguggga                                                     18


<210> 737
<211> 18
<212> RNA
<213> Homo sapiens

<400> 737
ucccacugca gagccugg                                                     18


<210> 738
<211> 22
<212> RNA
<213> Homo sapiens

<400> 738
cugggaggug ugauauugug gu                                                22


<210> 739
<211> 22
<212> RNA
<213> Homo sapiens

<400> 739
accacaauau cacaccuccc ag                                                22


<210> 740
<211> 22
<212> RNA
<213> Homo sapiens

<400> 740
gggaggugug aucucacacu cg                                                22


<210> 741
<211> 22
<212> RNA
<213> Homo sapiens

<400> 741
cgagugugag aucacaccuc cc                                                22


<210> 742
<211> 22
<212> RNA
<213> Homo sapiens

<400> 742
ugugauauca ugguuccugg ga                                                22


<210> 743
<211> 22
<212> RNA
<213> Homo sapiens

<400> 743
ucccaggaac caugauauca ca                                                22


<210> 744
<211> 22
<212> RNA
<213> Homo sapiens

<400> 744
ugugauaucg ugcuuccugg ga                                                22


<210> 745
<211> 22
<212> RNA
<213> Homo sapiens

<400> 745
ucccaggaag cacgauauca ca                                                22


<210> 746
<211> 18
<212> RNA
<213> Homo sapiens

<400> 746
ggugggcuuc ccggaggg                                                     18


<210> 747
<211> 18
<212> RNA
<213> Homo sapiens

<400> 747
cccuccggga agcccacc                                                     18


<210> 748
<211> 18
<212> RNA
<213> Homo sapiens

<400> 748
cacugcagga cucagcag                                                     18


<210> 749
<211> 18
<212> RNA
<213> Homo sapiens

<400> 749
cugcugaguc cugcagug                                                     18


<210> 750
<211> 17
<212> RNA
<213> Homo sapiens

<400> 750
ugagggagga gacugca                                                      17


<210> 751
<211> 17
<212> RNA
<213> Homo sapiens

<400> 751
ugcagucucc ucccuca                                                      17


<210> 752
<211> 18
<212> RNA
<213> Homo sapiens

<400> 752
gaggcugaag gaagaugg                                                     18


<210> 753
<211> 18
<212> RNA
<213> Homo sapiens

<400> 753
ccaucuuccu ucagccuc                                                     18


<210> 754
<211> 22
<212> RNA
<213> Homo sapiens

<400> 754
gucacugaug ucuguagcug ag                                                22


<210> 755
<211> 22
<212> RNA
<213> Homo sapiens

<400> 755
cucagcuaca gacaucagug ac                                                22


<210> 756
<211> 22
<212> RNA
<213> Homo sapiens

<400> 756
accugucugu ggaaaggagc ua                                                22


<210> 757
<211> 22
<212> RNA
<213> Homo sapiens

<400> 757
uagcuccuuu ccacagacag gu                                                22


<210> 758
<211> 22
<212> RNA
<213> Homo sapiens

<400> 758
agaguuaacu caaaauggac ua                                                22


<210> 759
<211> 22
<212> RNA
<213> Homo sapiens

<400> 759
uaguccauuu ugaguuaacu cu                                                22


<210> 760
<211> 22
<212> RNA
<213> Homo sapiens

<400> 760
uguugggauu cagcaggacc au                                                22


<210> 761
<211> 22
<212> RNA
<213> Homo sapiens

<400> 761
augguccugc ugaaucccaa ca                                                22


<210> 762
<211> 17
<212> RNA
<213> Homo sapiens

<400> 762
gaagauggac guacuuu                                                      17


<210> 763
<211> 17
<212> RNA
<213> Homo sapiens

<400> 763
aaaguacguc caucuuc                                                      17


<210> 764
<211> 21
<212> RNA
<213> Homo sapiens

<400> 764
ucugaauaga gucugaagag u                                                 21


<210> 765
<211> 21
<212> RNA
<213> Homo sapiens

<400> 765
acucuucaga cucuauucag a                                                 21


<210> 766
<211> 22
<212> RNA
<213> Homo sapiens

<400> 766
caaggagacg ggaacaugga gc                                                22


<210> 767
<211> 22
<212> RNA
<213> Homo sapiens

<400> 767
gcuccauguu cccgucuccu ug                                                22


<210> 768
<211> 20
<212> RNA
<213> Homo sapiens

<400> 768
aaaagcuggg cugagaggcg                                                   20


<210> 769
<211> 20
<212> RNA
<213> Homo sapiens

<400> 769
cgccucucag cccagcuuuu                                                   20


<210> 770
<211> 18
<212> RNA
<213> Homo sapiens

<400> 770
aggcuggagu gagcggag                                                     18


<210> 771
<211> 18
<212> RNA
<213> Homo sapiens

<400> 771
cuccgcucac uccagccu                                                     18


<210> 772
<211> 22
<212> RNA
<213> Homo sapiens

<400> 772
gcgacucuga aaacuagaag gu                                                22


<210> 773
<211> 22
<212> RNA
<213> Homo sapiens

<400> 773
accuucuagu uuucagaguc gc                                                22


<210> 774
<211> 20
<212> RNA
<213> Homo sapiens

<400> 774
aaagacucug caagaugccu                                                   20


<210> 775
<211> 20
<212> RNA
<213> Homo sapiens

<400> 775
aggcaucuug cagagucuuu                                                   20


<210> 776
<211> 21
<212> RNA
<213> Homo sapiens

<400> 776
acaggagugg gggugggaca u                                                 21


<210> 777
<211> 21
<212> RNA
<213> Homo sapiens

<400> 777
augucccacc cccacuccug u                                                 21


<210> 778
<211> 21
<212> RNA
<213> Homo sapiens

<400> 778
cgucccaccc cccacuccug u                                                 21


<210> 779
<211> 21
<212> RNA
<213> Homo sapiens

<400> 779
acaggagugg ggggugggac g                                                 21


<210> 780
<211> 18
<212> RNA
<213> Homo sapiens

<400> 780
aggagaagua aaguagaa                                                     18


<210> 781
<211> 18
<212> RNA
<213> Homo sapiens

<400> 781
uucuacuuua cuucuccu                                                     18


<210> 782
<211> 22
<212> RNA
<213> Homo sapiens

<400> 782
auggccagag cucacacaga gg                                                22


<210> 783
<211> 22
<212> RNA
<213> Homo sapiens

<400> 783
ccucugugug agcucuggcc au                                                22


<210> 784
<211> 21
<212> RNA
<213> Homo sapiens

<400> 784
ugggcucagg guacaaaggu u                                                 21


<210> 785
<211> 21
<212> RNA
<213> Homo sapiens

<400> 785
aaccuuugua cccugagccc a                                                 21


<210> 786
<211> 21
<212> RNA
<213> Homo sapiens

<400> 786
cacaggcuua gaaaagacag u                                                 21


<210> 787
<211> 21
<212> RNA
<213> Homo sapiens

<400> 787
acugucuuuu cuaagccugu g                                                 21


<210> 788
<211> 22
<212> RNA
<213> Homo sapiens

<400> 788
gugacugaua ccuuggaggc au                                                22


<210> 789
<211> 22
<212> RNA
<213> Homo sapiens

<400> 789
augccuccaa gguaucaguc ac                                                22


<210> 790
<211> 22
<212> RNA
<213> Homo sapiens

<400> 790
ugucgugggg cuugcuggcu ug                                                22


<210> 791
<211> 22
<212> RNA
<213> Homo sapiens

<400> 791
caagccagca agccccacga ca                                                22


<210> 792
<211> 17
<212> RNA
<213> Homo sapiens

<400> 792
acagggagga gauugua                                                      17


<210> 793
<211> 17
<212> RNA
<213> Homo sapiens

<400> 793
uacaaucucc ucccugu                                                      17


<210> 794
<211> 17
<212> RNA
<213> Homo sapiens

<400> 794
gccggacaag agggagg                                                      17


<210> 795
<211> 17
<212> RNA
<213> Homo sapiens

<400> 795
ccucccucuu guccggc                                                      17


<210> 796
<211> 17
<212> RNA
<213> Homo sapiens

<400> 796
uuggaggcgu ggguuuu                                                      17


<210> 797
<211> 17
<212> RNA
<213> Homo sapiens

<400> 797
aaaacccacg ccuccaa                                                      17


<210> 798
<211> 18
<212> RNA
<213> Homo sapiens

<400> 798
cucgaguugg aagaggcg                                                     18


<210> 799
<211> 18
<212> RNA
<213> Homo sapiens

<400> 799
cgccucuucc aacucgag                                                     18


<210> 800
<211> 21
<212> RNA
<213> Homo sapiens

<400> 800
cacggcaaaa gaaacaaucc a                                                 21


<210> 801
<211> 21
<212> RNA
<213> Homo sapiens

<400> 801
uggauuguuu cuuuugccgu g                                                 21


<210> 802
<211> 22
<212> RNA
<213> Homo sapiens

<400> 802
agauuguuuc uuuugccgug ca                                                22


<210> 803
<211> 22
<212> RNA
<213> Homo sapiens

<400> 803
ugcacggcaa aagaaacaau cu                                                22


<210> 804
<211> 17
<212> RNA
<213> Homo sapiens

<400> 804
ggugggggcu guuguuu                                                      17


<210> 805
<211> 17
<212> RNA
<213> Homo sapiens

<400> 805
aaacaacagc ccccacc                                                      17


<210> 806
<211> 20
<212> RNA
<213> Homo sapiens

<400> 806
ggcuccuugg ucuaggggua                                                   20


<210> 807
<211> 20
<212> RNA
<213> Homo sapiens

<400> 807
uaccccuaga ccaaggagcc                                                   20


<210> 808
<211> 22
<212> RNA
<213> Homo sapiens

<400> 808
cgucccgggg cugcgcgagg ca                                                22


<210> 809
<211> 22
<212> RNA
<213> Homo sapiens

<400> 809
ugccucgcgc agccccggga cg                                                22


<210> 810
<211> 22
<212> RNA
<213> Homo sapiens

<400> 810
uggggauuug gagaaguggu ga                                                22


<210> 811
<211> 22
<212> RNA
<213> Homo sapiens

<400> 811
ucaccacuuc uccaaauccc ca                                                22


<210> 812
<211> 17
<212> RNA
<213> Homo sapiens

<400> 812
ugguagagcu gaggaca                                                      17


<210> 813
<211> 17
<212> RNA
<213> Homo sapiens

<400> 813
uguccucagc ucuacca                                                      17


<210> 814
<211> 23
<212> RNA
<213> Homo sapiens

<400> 814
uugaauucuu ggccuuaagu gau                                               23


<210> 815
<211> 23
<212> RNA
<213> Homo sapiens

<400> 815
aucacuuaag gccaagaauu caa                                               23


<210> 816
<211> 20
<212> RNA
<213> Homo sapiens

<400> 816
gagcuugguc uguagcgguu                                                   20


<210> 817
<211> 20
<212> RNA
<213> Homo sapiens

<400> 817
aaccgcuaca gaccaagcuc                                                   20


<210> 818
<211> 20
<212> RNA
<213> Homo sapiens

<400> 818
ggauccgagu cacggcacca                                                   20


<210> 819
<211> 20
<212> RNA
<213> Homo sapiens

<400> 819
uggugccgug acucggaucc                                                   20


<210> 820
<211> 17
<212> RNA
<213> Homo sapiens

<400> 820
agggugugug uguuuuu                                                      17


<210> 821
<211> 17
<212> RNA
<213> Homo sapiens

<400> 821
aaaaacacac acacccu                                                      17


<210> 822
<211> 17
<212> RNA
<213> Homo sapiens

<400> 822
ccugguggcu uccuuuu                                                      17


<210> 823
<211> 17
<212> RNA
<213> Homo sapiens

<400> 823
aaaaggaagc caccagg                                                      17


<210> 824
<211> 22
<212> RNA
<213> Homo sapiens

<400> 824
ucacaaggua uugacuggcg ua                                                22


<210> 825
<211> 22
<212> RNA
<213> Homo sapiens

<400> 825
uacgccaguc aauaccuugu ga                                                22


<210> 826
<211> 19
<212> RNA
<213> Homo sapiens

<400> 826
agagguaggu guggaagaa                                                    19


<210> 827
<211> 19
<212> RNA
<213> Homo sapiens

<400> 827
uucuuccaca ccuaccucu                                                    19


<210> 828
<211> 22
<212> RNA
<213> Homo sapiens

<400> 828
ccaggaggcg gaggaggugg ag                                                22


<210> 829
<211> 22
<212> RNA
<213> Homo sapiens

<400> 829
cuccaccucc uccgccuccu gg                                                22


<210> 830
<211> 22
<212> RNA
<213> Homo sapiens

<400> 830
auagugguug ugaauuuacc uu                                                22


<210> 831
<211> 22
<212> RNA
<213> Homo sapiens

<400> 831
aagguaaauu cacaaccacu au                                                22


<210> 832
<211> 23
<212> RNA
<213> Homo sapiens

<400> 832
gauugagacu aguagggcua ggc                                               23


<210> 833
<211> 23
<212> RNA
<213> Homo sapiens

<400> 833
gccuagcccu acuagucuca auc                                               23


<210> 834
<211> 23
<212> RNA
<213> Homo sapiens

<400> 834
ugacacggag gguggcuugg gaa                                               23


<210> 835
<211> 23
<212> RNA
<213> Homo sapiens

<400> 835
uucccaagcc acccuccgug uca                                               23


<210> 836
<211> 17
<212> RNA
<213> Homo sapiens

<400> 836
gagacugggg uggggcc                                                      17


<210> 837
<211> 17
<212> RNA
<213> Homo sapiens

<400> 837
ggccccaccc cagucuc                                                      17


<210> 838
<211> 21
<212> RNA
<213> Homo sapiens

<400> 838
aagguuugga uagaugcaau a                                                 21


<210> 839
<211> 21
<212> RNA
<213> Homo sapiens

<400> 839
uauugcaucu auccaaaccu u                                                 21


<210> 840
<211> 22
<212> RNA
<213> Homo sapiens

<400> 840
cucaaguagu cugaccaggg ga                                                22


<210> 841
<211> 22
<212> RNA
<213> Homo sapiens

<400> 841
uccccugguc agacuacuug ag                                                22


<210> 842
<211> 18
<212> RNA
<213> Homo sapiens

<400> 842
gggugcgggc cggcgggg                                                     18


<210> 843
<211> 18
<212> RNA
<213> Homo sapiens

<400> 843
ccccgccggc ccgcaccc                                                     18


<210> 844
<211> 18
<212> RNA
<213> Homo sapiens

<400> 844
agagcagaag gaugagau                                                     18


<210> 845
<211> 18
<212> RNA
<213> Homo sapiens

<400> 845
aucucauccu ucugcucu                                                     18


<210> 846
<211> 21
<212> RNA
<213> Homo sapiens

<400> 846
uggcaaacgu ggaagccgag a                                                 21


<210> 847
<211> 21
<212> RNA
<213> Homo sapiens

<400> 847
ucucggcuuc cacguuugcc a                                                 21


<210> 848
<211> 18
<212> RNA
<213> Homo sapiens

<400> 848
gguggggggu guuguuuu                                                     18


<210> 849
<211> 18
<212> RNA
<213> Homo sapiens

<400> 849
aaaacaacac cccccacc                                                     18


<210> 850
<211> 22
<212> RNA
<213> Homo sapiens

<400> 850
cuagugcucu ccguuacaag ua                                                22


<210> 851
<211> 22
<212> RNA
<213> Homo sapiens

<400> 851
uacuuguaac ggagagcacu ag                                                22


<210> 852
<211> 22
<212> RNA
<213> Homo sapiens

<400> 852
caagggacca agcauucauu au                                                22


<210> 853
<211> 22
<212> RNA
<213> Homo sapiens

<400> 853
auaaugaaug cuuggucccu ug                                                22


<210> 854
<211> 22
<212> RNA
<213> Homo sapiens

<400> 854
caggaaggau uuagggacag gc                                                22


<210> 855
<211> 22
<212> RNA
<213> Homo sapiens

<400> 855
gccugucccu aaauccuucc ug                                                22


<210> 856
<211> 22
<212> RNA
<213> Homo sapiens

<400> 856
cuauuaagga cauuugugau uc                                                22


<210> 857
<211> 22
<212> RNA
<213> Homo sapiens

<400> 857
gaaucacaaa uguccuuaau ag                                                22


<210> 858
<211> 22
<212> RNA
<213> Homo sapiens

<400> 858
auuaaggaca uuugugauug au                                                22


<210> 859
<211> 22
<212> RNA
<213> Homo sapiens

<400> 859
aucaaucaca aauguccuua au                                                22


<210> 860
<211> 17
<212> RNA
<213> Homo sapiens

<400> 860
gaggcugagc ugaggag                                                      17


<210> 861
<211> 17
<212> RNA
<213> Homo sapiens

<400> 861
cuccucagcu cagccuc                                                      17


<210> 862
<211> 22
<212> RNA
<213> Homo sapiens

<400> 862
cgcgcggccg ugcucggagc ag                                                22


<210> 863
<211> 22
<212> RNA
<213> Homo sapiens

<400> 863
cugcuccgag cacggccgcg cg                                                22


<210> 864
<211> 21
<212> RNA
<213> Homo sapiens

<400> 864
agccaagugg aaguuacuuu a                                                 21


<210> 865
<211> 21
<212> RNA
<213> Homo sapiens

<400> 865
uaaaguaacu uccacuuggc u                                                 21


<210> 866
<211> 17
<212> RNA
<213> Homo sapiens

<400> 866
ggagugggcu ggugguu                                                      17


<210> 867
<211> 17
<212> RNA
<213> Homo sapiens

<400> 867
aaccaccagc ccacucc                                                      17


<210> 868
<211> 22
<212> RNA
<213> Homo sapiens

<400> 868
uuucuauuuc ucaguggggc uc                                                22


<210> 869
<211> 22
<212> RNA
<213> Homo sapiens

<400> 869
gagccccacu gagaaauaga aa                                                22


<210> 870
<211> 22
<212> RNA
<213> Homo sapiens

<400> 870
aacccagugg gcuauggaaa ug                                                22


<210> 871
<211> 22
<212> RNA
<213> Homo sapiens

<400> 871
cauuuccaua gcccacuggg uu                                                22


<210> 872
<211> 17
<212> RNA
<213> Homo sapiens

<400> 872
gggguggucu guuguug                                                      17


<210> 873
<211> 17
<212> RNA
<213> Homo sapiens

<400> 873
caacaacaga ccacccc                                                      17


<210> 874
<211> 20
<212> RNA
<213> Homo sapiens

<400> 874
aaaaggcggg agaagcccca                                                   20


<210> 875
<211> 20
<212> RNA
<213> Homo sapiens

<400> 875
uggggcuucu cccgccuuuu                                                   20


<210> 876
<211> 20
<212> RNA
<213> Homo sapiens

<400> 876
uaacggccgc gguacccuaa                                                   20


<210> 877
<211> 20
<212> RNA
<213> Homo sapiens

<400> 877
uuaggguacc gcggccguua                                                   20


<210> 878
<211> 17
<212> RNA
<213> Homo sapiens

<400> 878
gcugggcgag gcuggca                                                      17


<210> 879
<211> 17
<212> RNA
<213> Homo sapiens

<400> 879
ugccagccuc gcccagc                                                      17


<210> 880
<211> 19
<212> RNA
<213> Homo sapiens

<400> 880
agagcuggcu gaagggcag                                                    19


<210> 881
<211> 19
<212> RNA
<213> Homo sapiens

<400> 881
cugcccuuca gccagcucu                                                    19


<210> 882
<211> 18
<212> RNA
<213> Homo sapiens

<400> 882
agggggcggg cuccggcg                                                     18


<210> 883
<211> 18
<212> RNA
<213> Homo sapiens

<400> 883
cgccggagcc cgcccccu                                                     18


<210> 884
<211> 22
<212> RNA
<213> Homo sapiens

<400> 884
ucugguaaga gauuugggca ua                                                22


<210> 885
<211> 22
<212> RNA
<213> Homo sapiens

<400> 885
uaugcccaaa ucucuuacca ga                                                22


<210> 886
<211> 22
<212> RNA
<213> Homo sapiens

<400> 886
aauguggacu ggugugacca aa                                                22


<210> 887
<211> 22
<212> RNA
<213> Homo sapiens

<400> 887
uuuggucaca ccaguccaca uu                                                22


<210> 888
<211> 17
<212> RNA
<213> Homo sapiens

<400> 888
ggggcugggc gcgcgcc                                                      17


<210> 889
<211> 17
<212> RNA
<213> Homo sapiens

<400> 889
ggcgcgcgcc cagcccc                                                      17


<210> 890
<211> 21
<212> RNA
<213> Homo sapiens

<400> 890
agaaggccuu uccaucucug u                                                 21


<210> 891
<211> 21
<212> RNA
<213> Homo sapiens

<400> 891
acagagaugg aaaggccuuc u                                                 21


<210> 892
<211> 22
<212> RNA
<213> Homo sapiens

<400> 892
ccagacugug gcugaccaga gg                                                22


<210> 893
<211> 22
<212> RNA
<213> Homo sapiens

<400> 893
ccucugguca gccacagucu gg                                                22


<210> 894
<211> 21
<212> RNA
<213> Homo sapiens

<400> 894
aauguaaaca ggcuuuuugc u                                                 21


<210> 895
<211> 21
<212> RNA
<213> Homo sapiens

<400> 895
agcaaaaagc cuguuuacau u                                                 21


<210> 896
<211> 22
<212> RNA
<213> Homo sapiens

<400> 896
gaggaaacug aagcugagag gg                                                22


<210> 897
<211> 22
<212> RNA
<213> Homo sapiens

<400> 897
cccucucagc uucaguuucc uc                                                22


<210> 898
<211> 17
<212> RNA
<213> Homo sapiens

<400> 898
cuccgggacg gcugggc                                                      17


<210> 899
<211> 17
<212> RNA
<213> Homo sapiens

<400> 899
gcccagccgu cccggag                                                      17


<210> 900
<211> 22
<212> RNA
<213> Homo sapiens

<400> 900
ugggcuggca gggcaagugc ug                                                22


<210> 901
<211> 22
<212> RNA
<213> Homo sapiens

<400> 901
cagcacuugc ccugccagcc ca                                                22


<210> 902
<211> 17
<212> RNA
<213> Homo sapiens

<400> 902
aagacugaga ggaggga                                                      17


<210> 903
<211> 17
<212> RNA
<213> Homo sapiens

<400> 903
ucccuccucu cagucuu                                                      17


<210> 904
<211> 17
<212> RNA
<213> Homo sapiens

<400> 904
ugagguagua guuucuu                                                      17


<210> 905
<211> 17
<212> RNA
<213> Homo sapiens

<400> 905
aagaaacuac uaccuca                                                      17


<210> 906
<211> 21
<212> RNA
<213> Homo sapiens

<400> 906
uaugugaccu cggaugaauc a                                                 21


<210> 907
<211> 21
<212> RNA
<213> Homo sapiens

<400> 907
ugauucaucc gaggucacau a                                                 21


<210> 908
<211> 22
<212> RNA
<213> Homo sapiens

<400> 908
gcugaugaug auggugcuga ag                                                22


<210> 909
<211> 22
<212> RNA
<213> Homo sapiens

<400> 909
cuucagcacc aucaucauca gc                                                22


<210> 910
<211> 22
<212> RNA
<213> Homo sapiens

<400> 910
uuuaagcagg aaauagaauu ua                                                22


<210> 911
<211> 22
<212> RNA
<213> Homo sapiens

<400> 911
uaaauucuau uuccugcuua aa                                                22


<210> 912
<211> 22
<212> RNA
<213> Homo sapiens

<400> 912
ugugacaaua gagaugaaca ug                                                22


<210> 913
<211> 22
<212> RNA
<213> Homo sapiens

<400> 913
cauguucauc ucuauuguca ca                                                22


<210> 914
<211> 18
<212> RNA
<213> Homo sapiens

<400> 914
aggcugggcu gggacgga                                                     18


<210> 915
<211> 18
<212> RNA
<213> Homo sapiens

<400> 915
uccgucccag cccagccu                                                     18


<210> 916
<211> 20
<212> RNA
<213> Homo sapiens

<400> 916
aaaugggugg ucugaggcaa                                                   20


<210> 917
<211> 20
<212> RNA
<213> Homo sapiens

<400> 917
uugccucaga ccacccauuu                                                   20


<210> 918
<211> 20
<212> RNA
<213> Homo sapiens

<400> 918
cuggguuggg cugggcuggg                                                   20


<210> 919
<211> 20
<212> RNA
<213> Homo sapiens

<400> 919
cccagcccag cccaacccag                                                   20


<210> 920
<211> 17
<212> RNA
<213> Homo sapiens

<400> 920
gcggggcugg gcgcgcg                                                      17


<210> 921
<211> 17
<212> RNA
<213> Homo sapiens

<400> 921
cgcgcgccca gccccgc                                                      17


<210> 922
<211> 22
<212> RNA
<213> Homo sapiens

<400> 922
acuaaaggau auagaagguu uu                                                22


<210> 923
<211> 22
<212> RNA
<213> Homo sapiens

<400> 923
aaaaccuucu auauccuuua gu                                                22


<210> 924
<211> 22
<212> RNA
<213> Homo sapiens

<400> 924
ugagggagua ggauguaugg uu                                                22


<210> 925
<211> 22
<212> RNA
<213> Homo sapiens

<400> 925
aaccauacau ccuacucccu ca                                                22


<210> 926
<211> 22
<212> RNA
<213> Homo sapiens

<400> 926
gaagaacugu ugcauuugcc cu                                                22


<210> 927
<211> 22
<212> RNA
<213> Homo sapiens

<400> 927
agggcaaaug caacaguucu uc                                                22


<210> 928
<211> 22
<212> RNA
<213> Homo sapiens

<400> 928
cagggccuca cuguaucgcc ca                                                22


<210> 929
<211> 22
<212> RNA
<213> Homo sapiens

<400> 929
ugggcgauac agugaggccc ug                                                22


<210> 930
<211> 22
<212> RNA
<213> Homo sapiens

<400> 930
agacugacgg cuggaggccc au                                                22


<210> 931
<211> 22
<212> RNA
<213> Homo sapiens

<400> 931
augggccucc agccgucagu cu                                                22


<210> 932
<211> 18
<212> RNA
<213> Homo sapiens

<400> 932
acaggcagga uuggggaa                                                     18


<210> 933
<211> 18
<212> RNA
<213> Homo sapiens

<400> 933
uuccccaauc cugccugu                                                     18


<210> 934
<211> 22
<212> RNA
<213> Homo sapiens

<400> 934
aggacuggac ucccggcagc cc                                                22


<210> 935
<211> 22
<212> RNA
<213> Homo sapiens

<400> 935
gggcugccgg gaguccaguc cu                                                22


<210> 936
<211> 17
<212> RNA
<213> Homo sapiens

<400> 936
gggagaaggg ucggggc                                                      17


<210> 937
<211> 17
<212> RNA
<213> Homo sapiens

<400> 937
gccccgaccc uucuccc                                                      17


<210> 938
<211> 25
<212> RNA
<213> Homo sapiens

<400> 938
aaauaugaug aaacucacag cugag                                             25


<210> 939
<211> 25
<212> RNA
<213> Homo sapiens

<400> 939
cucagcugug aguuucauca uauuu                                             25


<210> 940
<211> 26
<212> RNA
<213> Homo sapiens

<400> 940
gcucagggau gauaacugug cugaga                                            26


<210> 941
<211> 26
<212> RNA
<213> Homo sapiens

<400> 941
ucucagcaca guuaucaucc cugagc                                            26


<210> 942
<211> 18
<212> RNA
<213> Homo sapiens

<400> 942
cagcagugcg cagggcug                                                     18


<210> 943
<211> 18
<212> RNA
<213> Homo sapiens

<400> 943
cagcccugcg cacugcug                                                     18


<210> 944
<211> 22
<212> RNA
<213> Homo sapiens

<400> 944
gcuaaggaag uccugugcuc ag                                                22


<210> 945
<211> 22
<212> RNA
<213> Homo sapiens

<400> 945
cugagcacag gacuuccuua gc                                                22


<210> 946
<211> 21
<212> RNA
<213> Homo sapiens

<400> 946
ugacucugcc uguaggccgg u                                                 21


<210> 947
<211> 21
<212> RNA
<213> Homo sapiens

<400> 947
accggccuac aggcagaguc a                                                 21


<210> 948
<211> 21
<212> RNA
<213> Homo sapiens

<400> 948
gaccgagagg gccucggcug u                                                 21


<210> 949
<211> 21
<212> RNA
<213> Homo sapiens

<400> 949
acagccgagg cccucucggu c                                                 21


<210> 950
<211> 21
<212> RNA
<213> Homo sapiens

<400> 950
ggggggaugu gcaugcuggu u                                                 21


<210> 951
<211> 21
<212> RNA
<213> Homo sapiens

<400> 951
aaccagcaug cacauccccc c                                                 21


<210> 952
<211> 22
<212> RNA
<213> Homo sapiens

<400> 952
uggucugcaa agagaugacu gu                                                22


<210> 953
<211> 22
<212> RNA
<213> Homo sapiens

<400> 953
acagucaucu cuuugcagac ca                                                22


<210> 954
<211> 22
<212> RNA
<213> Homo sapiens

<400> 954
ucauuauaug uaugaucugg ac                                                22


<210> 955
<211> 22
<212> RNA
<213> Homo sapiens

<400> 955
guccagauca uacauauaau ga                                                22


<210> 956
<211> 18
<212> RNA
<213> Homo sapiens

<400> 956
cccagcagga cgggagcg                                                     18


<210> 957
<211> 18
<212> RNA
<213> Homo sapiens

<400> 957
cgcucccguc cugcuggg                                                     18


<210> 958
<211> 17
<212> RNA
<213> Homo sapiens

<400> 958
auggagaagg cuucuga                                                      17


<210> 959
<211> 17
<212> RNA
<213> Homo sapiens

<400> 959
ucagaagccu ucuccau                                                      17


<210> 960
<211> 17
<212> RNA
<213> Homo sapiens

<400> 960
ccccggggag cccggcg                                                      17


<210> 961
<211> 17
<212> RNA
<213> Homo sapiens

<400> 961
cgccgggcuc cccgggg                                                      17


<210> 962
<211> 22
<212> RNA
<213> Homo sapiens

<400> 962
uggaaggagg uugccggacg cu                                                22


<210> 963
<211> 22
<212> RNA
<213> Homo sapiens

<400> 963
agcguccggc aaccuccuuc ca                                                22


<210> 964
<211> 17
<212> RNA
<213> Homo sapiens

<400> 964
ggauggagga ggggucu                                                      17


<210> 965
<211> 17
<212> RNA
<213> Homo sapiens

<400> 965
agaccccucc uccaucc                                                      17


<210> 966
<211> 17
<212> RNA
<213> Homo sapiens

<400> 966
guggaccugg cugggac                                                      17


<210> 967
<211> 17
<212> RNA
<213> Homo sapiens

<400> 967
gucccagcca gguccac                                                      17


<210> 968
<211> 21
<212> RNA
<213> Homo sapiens

<400> 968
ucgugcauau aucuaccaca u                                                 21


<210> 969
<211> 21
<212> RNA
<213> Homo sapiens

<400> 969
augugguaga uauaugcacg a                                                 21


<210> 970
<211> 21
<212> RNA
<213> Homo sapiens

<400> 970
ugugguagau auaugcacga u                                                 21


<210> 971
<211> 21
<212> RNA
<213> Homo sapiens

<400> 971
aucgugcaua uaucuaccac a                                                 21


<210> 972
<211> 22
<212> RNA
<213> Homo sapiens

<400> 972
ugagccgagc ugagcuuagc ug                                                22


<210> 973
<211> 22
<212> RNA
<213> Homo sapiens

<400> 973
cagcuaagcu cagcucggcu ca                                                22


<210> 974
<211> 22
<212> RNA
<213> Homo sapiens

<400> 974
gagcuuggau gagcugggcu ga                                                22


<210> 975
<211> 22
<212> RNA
<213> Homo sapiens

<400> 975
ucagcccagc ucauccaagc uc                                                22


<210> 976
<211> 22
<212> RNA
<213> Homo sapiens

<400> 976
gcugaacugg gcugagcugg gc                                                22


<210> 977
<211> 22
<212> RNA
<213> Homo sapiens

<400> 977
gcccagcuca gcccaguuca gc                                                22


<210> 978
<211> 21
<212> RNA
<213> Homo sapiens

<400> 978
uuaguccugc cuguagguuu a                                                 21


<210> 979
<211> 21
<212> RNA
<213> Homo sapiens

<400> 979
uaaaccuaca ggcaggacua a                                                 21


<210> 980
<211> 20
<212> RNA
<213> Homo sapiens

<400> 980
uugggcuggg cuggguuggg                                                   20


<210> 981
<211> 20
<212> RNA
<213> Homo sapiens

<400> 981
cccaacccag cccagcccaa                                                   20


<210> 982
<211> 20
<212> RNA
<213> Homo sapiens

<400> 982
uaggaugggg gugagaggug                                                   20


<210> 983
<211> 20
<212> RNA
<213> Homo sapiens

<400> 983
caccucucac ccccauccua                                                   20


<210> 984
<211> 22
<212> RNA
<213> Homo sapiens

<400> 984
aaaaguaauu guggauuuug cu                                                22


<210> 985
<211> 22
<212> RNA
<213> Homo sapiens

<400> 985
agcaaaaucc acaauuacuu uu                                                22


<210> 986
<211> 22
<212> RNA
<213> Homo sapiens

<400> 986
caaaaaccgg caauuacuuu ug                                                22


<210> 987
<211> 22
<212> RNA
<213> Homo sapiens

<400> 987
caaaaguaau ugccgguuuu ug                                                22


<210> 988
<211> 22
<212> RNA
<213> Homo sapiens

<400> 988
gaaaacgaca augacuuuug ca                                                22


<210> 989
<211> 22
<212> RNA
<213> Homo sapiens

<400> 989
ugcaaaaguc auugucguuu uc                                                22


<210> 990
<211> 21
<212> RNA
<213> Homo sapiens

<400> 990
caaaaacugc aauuacuuuc a                                                 21


<210> 991
<211> 21
<212> RNA
<213> Homo sapiens

<400> 991
ugaaaguaau ugcaguuuuu g                                                 21


<210> 992
<211> 21
<212> RNA
<213> Homo sapiens

<400> 992
aaagguaauu gugguuucug c                                                 21


<210> 993
<211> 21
<212> RNA
<213> Homo sapiens

<400> 993
gcagaaacca caauuaccuu u                                                 21


<210> 994
<211> 22
<212> RNA
<213> Homo sapiens

<400> 994
caaaaacugc aguuacuuuu gc                                                22


<210> 995
<211> 22
<212> RNA
<213> Homo sapiens

<400> 995
gcaaaaguaa cugcaguuuu ug                                                22


<210> 996
<211> 20
<212> RNA
<213> Homo sapiens

<400> 996
aaaagugauu gcaguguuug                                                   20


<210> 997
<211> 20
<212> RNA
<213> Homo sapiens

<400> 997
caaacacugc aaucacuuuu                                                   20


<210> 998
<211> 22
<212> RNA
<213> Homo sapiens

<400> 998
aaagguaauu gcaguuuuuc cc                                                22


<210> 999
<211> 22
<212> RNA
<213> Homo sapiens

<400> 999
gggaaaaacu gcaauuaccu uu                                                22


<210> 1000
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1000
uaaaaacugc aauuacuuuu a                                                 21


<210> 1001
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1001
uaaaaguaau ugcaguuuuu a                                                 21


<210> 1002
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1002
ugcaaaagua auugcaguuu uug                                               23


<210> 1003
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1003
caaaaacugc aauuacuuuu gca                                               23


<210> 1004
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1004
aaaaguaacu gcgguuuuug a                                                 21


<210> 1005
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1005
ucaaaaaccg caguuacuuu u                                                 21


<210> 1006
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1006
aacggcaaug acuuuuguac ca                                                22


<210> 1007
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1007
ugguacaaaa gucauugccg uu                                                22


<210> 1008
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1008
caaaaacugc aguuacuuuu gu                                                22


<210> 1009
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1009
acaaaaguaa cugcaguuuu ug                                                22


<210> 1010
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1010
aaaaguaauu gcgguuuuug cc                                                22


<210> 1011
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1011
ggcaaaaacc gcaauuacuu uu                                                22


<210> 1012
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1012
aaaaggcauu gugguuuuug                                                   20


<210> 1013
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1013
caaaaaccac aaugccuuuu                                                   20


<210> 1014
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1014
cggcccgggc ugcugcuguu ccu                                               23


<210> 1015
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1015
aggaacagca gcagcccggg ccg                                               23


<210> 1016
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1016
agagguauag ggcaugggaa                                                   20


<210> 1017
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1017
uucccaugcc cuauaccucu                                                   20


<210> 1018
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1018
uuccuaugca uauacuucuu ug                                                22


<210> 1019
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1019
caaagaagua uaugcauagg aa                                                22


<210> 1020
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1020
aucauagagg aaaauccaug uu                                                22


<210> 1021
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1021
aacauggauu uuccucuaug au                                                22


<210> 1022
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1022
cguggauauu ccuucuaugu uu                                                22


<210> 1023
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1023
aaacauagaa ggaauaucca cg                                                22


<210> 1024
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1024
ugaguauuac auggccaauc uc                                                22


<210> 1025
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1025
gagauuggcc auguaauacu ca                                                22


<210> 1026
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1026
cuuccgcccc gccgggcguc g                                                 21


<210> 1027
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1027
cgacgcccgg cggggcggaa g                                                 21


<210> 1028
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1028
uagcuuauca gacugauguu ga                                                22


<210> 1029
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1029
ucaacaucag ucugauaagc ua                                                22


<210> 1030
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1030
cacuagauug ugagcuccug ga                                                22


<210> 1031
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1031
uccaggagcu cacaaucuag ug                                                22


<210> 1032
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1032
aaggagcuca cagucuauug ag                                                22


<210> 1033
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1033
cucaauagac ugugagcucc uu                                                22


<210> 1034
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1034
uacgucaucg uugucaucgu ca                                                22


<210> 1035
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1035
ugacgaugac aacgaugacg ua                                                22


<210> 1036
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1036
cacgcucaug cacacaccca ca                                                22


<210> 1037
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1037
ugugggugug ugcaugagcg ug                                                22


<210> 1038
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1038
caacaccagu cgaugggcug u                                                 21


<210> 1039
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1039
acagcccauc gacugguguu g                                                 21


<210> 1040
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1040
uucaccaccu ucuccaccca gc                                                22


<210> 1041
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1041
gcugggugga gaagguggug aa                                                22


<210> 1042
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1042
cggguagaga gggcaguggg agg                                               23


<210> 1043
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1043
ccucccacug cccucucuac ccg                                               23


<210> 1044
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1044
aauccuugcu accugggu                                                     18


<210> 1045
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1045
acccagguag caaggauu                                                     18


<210> 1046
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1046
caauuuagug ugugugauau uu                                                22


<210> 1047
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1047
aaauaucaca cacacuaaau ug                                                22


<210> 1048
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1048
uauugcacau uacuaaguug ca                                                22


<210> 1049
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1049
ugcaacuuag uaaugugcaa ua                                                22


<210> 1050
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1050
ccuauucuug auuacuuguu uc                                                22


<210> 1051
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1051
gaaacaagua aucaagaaua gg                                                22


<210> 1052
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1052
uucaaguaau ccaggauagg cu                                                22


<210> 1053
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1053
agccuauccu ggauuacuug aa                                                22


<210> 1054
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1054
ccaguuaccg cuuccgcuac cgc                                               23


<210> 1055
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1055
gcgguagcgg aagcgguaac ugg                                               23


<210> 1056
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1056
gauuucagug gagugaaguu c                                                 21


<210> 1057
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1057
gaacuucacu ccacugaaau c                                                 21


<210> 1058
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1058
uccuucauuc caccggaguc ug                                                22


<210> 1059
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1059
cagacuccgg uggaaugaag ga                                                22


<210> 1060
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1060
aaaauggugc ccuagugacu aca                                               23


<210> 1061
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1061
uguagucacu agggcaccau uuu                                               23


<210> 1062
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1062
caagucacua gugguuccgu u                                                 21


<210> 1063
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1063
aacggaacca cuagugacuu g                                                 21


<210> 1064
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1064
ccaguauuaa cugugcugcu ga                                                22


<210> 1065
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1065
ucagcagcac aguuaauacu gg                                                22


<210> 1066
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1066
ucccccaggu gugauucuga uuu                                               23


<210> 1067
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1067
aaaucagaau cacaccuggg gga                                               23


<210> 1068
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1068
aaaagcuggg uugagagggc ga                                                22


<210> 1069
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1069
ucgcccucuc aacccagcuu uu                                                22


<210> 1070
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1070
uggacggaga acugauaagg gu                                                22


<210> 1071
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1071
acccuuauca guucuccguc ca                                                22


<210> 1072
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1072
uggugggccg cagaacaugu gc                                                22


<210> 1073
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1073
gcacauguuc ugcggcccac ca                                                22


<210> 1074
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1074
agugccugcu augugccagg ca                                                22


<210> 1075
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1075
ugccuggcac auagcaggca cu                                                22


<210> 1076
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1076
cuuggcaccu agcaagcacu ca                                                22


<210> 1077
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1077
ugagugcuug cuaggugcca ag                                                22


<210> 1078
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1078
uuauugcuua agaauacgcg uag                                               23


<210> 1079
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1079
cuacgcguau ucuuaagcaa uaa                                               23


<210> 1080
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1080
uugcauaguc acaaaaguga uc                                                22


<210> 1081
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1081
gaucacuuuu gugacuaugc aa                                                22


<210> 1082
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1082
gugaauuacc gaagggccau aa                                                22


<210> 1083
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1083
uuauggcccu ucgguaauuc ac                                                22


<210> 1084
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1084
uauggcacug guagaauuca cu                                                22


<210> 1085
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1085
agugaauucu accagugcca ua                                                22


<210> 1086
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1086
ugauauguuu gauauauuag gu                                                22


<210> 1087
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1087
accuaauaua ucaaacauau ca                                                22


<210> 1088
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1088
ugauauguuu gauauugggu u                                                 21


<210> 1089
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1089
aacccaauau caaacauauc a                                                 21


<210> 1090
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1090
agcaggugcg gggcggcg                                                     18


<210> 1091
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1091
cgccgccccg caccugcu                                                     18


<210> 1092
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1092
cagugcaagu guagaugccg a                                                 21


<210> 1093
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1093
ucggcaucua cacuugcacu g                                                 21


<210> 1094
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1094
uauguaauau gguccacauc uu                                                22


<210> 1095
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1095
aagaugugga ccauauuaca ua                                                22


<210> 1096
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1096
aauauaacac agauggccug u                                                 21


<210> 1097
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1097
acaggccauc uguguuauau u                                                 21


<210> 1098
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1098
aucgggaaug ucguguccgc cc                                                22


<210> 1099
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1099
gggcggacac gacauucccg au                                                22


<210> 1100
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1100
aaugacacga ucacucccgu uga                                               23


<210> 1101
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1101
ucaacgggag ugaucguguc auu                                               23


<210> 1102
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1102
uacucaggag aguggcaauc ac                                                22


<210> 1103
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1103
gugauugcca cucuccugag ua                                                22


<210> 1104
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1104
uggaagacua gugauuuugu ugu                                               23


<210> 1105
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1105
acaacaaaau cacuagucuu cca                                               23


<210> 1106
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1106
auaaagcuag auaaccgaaa gu                                                22


<210> 1107
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1107
acuuucgguu aucuagcuuu au                                                22


<210> 1108
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1108
ucuuugguua ucuagcugua uga                                               23


<210> 1109
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1109
ucauacagcu agauaaccaa aga                                               23


<210> 1110
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1110
acaggugagg uucuugggag cc                                                22


<210> 1111
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1111
ggcucccaag aaccucaccu gu                                                22


<210> 1112
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1112
ucccugagac ccuuuaaccu guga                                              24


<210> 1113
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1113
ucacagguua aagggucuca ggga                                              24


<210> 1114
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1114
caacaaaucc cagucuaccu aa                                                22


<210> 1115
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1115
uuagguagac ugggauuugu ug                                                22


<210> 1116
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1116
cguguucaca gcggaccuug au                                                22


<210> 1117
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1117
aucaaggucc gcugugaaca cg                                                22


<210> 1118
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1118
uaaggcacgc ggugaaugcc                                                   20


<210> 1119
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1119
ggcauucacc gcgugccuua                                                   20


<210> 1120
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1120
aacacaccug guuaaccucu uu                                                22


<210> 1121
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1121
aaagagguua accaggugug uu                                                22


<210> 1122
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1122
uaacagucua cagccauggu cg                                                22


<210> 1123
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1123
cgaccauggc uguagacugu ua                                                22


<210> 1124
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1124
accguggcuu ucgauuguua cu                                                22


<210> 1125
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1125
aguaacaauc gaaagccacg gu                                                22


<210> 1126
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1126
uaacagucuc cagucacggc c                                                 21


<210> 1127
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1127
ggccgugacu ggagacuguu a                                                 21


<210> 1128
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1128
accuuggcuc uagacugcuu acu                                               23


<210> 1129
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1129
aguaagcagu cuagagccaa ggu                                               23


<210> 1130
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1130
ucucacacag aaaucgcacc cgu                                               23


<210> 1131
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1131
acgggugcga uuucugugug aga                                               23


<210> 1132
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1132
ugguugacca uagaacaugc gc                                                22


<210> 1133
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1133
gcgcauguuc uauggucaac ca                                                22


<210> 1134
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1134
caguaacaaa gauucauccu ugu                                               23


<210> 1135
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1135
acaaggauga aucuuuguua cug                                               23


<210> 1136
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1136
agaguugagu cuggacgucc cg                                                22


<210> 1137
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1137
cgggacgucc agacucaacu cu                                                22


<210> 1138
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1138
agaauugugg cuggacaucu gu                                                22


<210> 1139
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1139
acagaugucc agccacaauu cu                                                22


<210> 1140
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1140
ugauugucca aacgcaauuc u                                                 21


<210> 1141
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1141
agaauugcgu uuggacaauc a                                                 21


<210> 1142
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1142
uauagggauu ggagccgugg cg                                                22


<210> 1143
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1143
cgccacggcu ccaaucccua ua                                                22


<210> 1144
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1144
uauggcuuuu uauuccuaug uga                                               23


<210> 1145
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1145
ucacauagga auaaaaagcc aua                                               23


<210> 1146
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1146
auguagggcu aaaagccaug gg                                                22


<210> 1147
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1147
cccauggcuu uuagcccuac au                                                22


<210> 1148
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1148
uauggcuuuu cauuccuaug uga                                               23


<210> 1149
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1149
ucacauagga augaaaagcc aua                                               23


<210> 1150
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1150
aaccaucgac cguugagugg ac                                                22


<210> 1151
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1151
guccacucaa cggucgaugg uu                                                22


<210> 1152
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1152
aacauucaac cugucgguga gu                                                22


<210> 1153
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1153
acucaccgac agguugaaug uu                                                22


<210> 1154
<211> 25
<212> RNA
<213> Homo sapiens

<400> 1154
cuuccagacg cuccgcccca cgucg                                             25


<210> 1155
<211> 25
<212> RNA
<213> Homo sapiens

<400> 1155
cgacgugggg cggagcgucu ggaag                                             25


<210> 1156
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1156
aacaacaaaa ucacuagucu ucca                                              24


<210> 1157
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1157
uggaagacua gugauuuugu uguu                                              24


<210> 1158
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1158
agguagacug ggauuuguug uu                                                22


<210> 1159
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1159
aacaacaaau cccagucuac cu                                                22


<210> 1160
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1160
aaacaccauu gucacacucc ac                                                22


<210> 1161
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1161
guggagugug acaauggugu uu                                                22


<210> 1162
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1162
uuuaguguga uaauggcguu uga                                               23


<210> 1163
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1163
ucaaacgcca uuaucacacu aaa                                               23


<210> 1164
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1164
uauggaaaga cuuugccacu cu                                                22


<210> 1165
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1165
agaguggcaa agucuuucca ua                                                22


<210> 1166
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1166
aguggcaaag ucuuuccaua u                                                 21


<210> 1167
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1167
auauggaaag acuuugccac u                                                 21


<210> 1168
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1168
cagcccggau cccagcccac uu                                                22


<210> 1169
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1169
aagugggcug ggauccgggc ug                                                22


<210> 1170
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1170
guggguuggg gcgggcucug                                                   20


<210> 1171
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1171
cagagcccgc cccaacccac                                                   20


<210> 1172
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1172
uucgggcugg ccugcugcuc cgg                                               23


<210> 1173
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1173
ccggagcagc aggccagccc gaa                                               23


<210> 1174
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1174
ugugcagcag gccaaccgag a                                                 21


<210> 1175
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1175
ucucgguugg ccugcugcac a                                                 21


<210> 1176
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1176
cagggcagga agaaguggac aa                                                22


<210> 1177
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1177
uuguccacuu cuuccugccc ug                                                22


<210> 1178
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1178
guccacuucu gccugcccug cc                                                22


<210> 1179
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1179
ggcagggcag gcagaagugg ac                                                22


<210> 1180
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1180
uuuggacaga aaacacgcag gu                                                22


<210> 1181
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1181
accugcgugu uuucugucca aa                                                22


<210> 1182
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1182
ccugcguguu uucuguccaa                                                   20


<210> 1183
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1183
uuggacagaa aacacgcagg                                                   20


<210> 1184
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1184
ugccgcccuc ucgcugcucu ag                                                22


<210> 1185
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1185
cuagagcagc gagagggcgg ca                                                22


<210> 1186
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1186
gagggcagcg uggguguggc gga                                               23


<210> 1187
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1187
uccgccacac ccacgcugcc cuc                                               23


<210> 1188
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1188
aggagcuagc caggcauaug ca                                                22


<210> 1189
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1189
ugcauaugcc uggcuagcuc cu                                                22


<210> 1190
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1190
auaugccugg cuagcuccuc                                                   20


<210> 1191
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1191
gaggagcuag ccaggcauau                                                   20


<210> 1192
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1192
cggcgcgacc ggcccgggg                                                    19


<210> 1193
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1193
ccccgggccg gucgcgccg                                                    19


<210> 1194
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1194
ucuugaaguc agaacccgca a                                                 21


<210> 1195
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1195
uugcggguuc ugacuucaag a                                                 21


<210> 1196
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1196
aacucguguu caaagccuuu ag                                                22


<210> 1197
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1197
cuaaaggcuu ugaacacgag uu                                                22


<210> 1198
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1198
ccuggacacc gcucagccgg ccg                                               23


<210> 1199
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1199
cggccggcug agcggugucc agg                                               23


<210> 1200
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1200
acucggcugc gguggacaag u                                                 21


<210> 1201
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1201
acuuguccac cgcagccgag u                                                 21


<210> 1202
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1202
ucacucucac cuugcuuugc                                                   20


<210> 1203
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1203
gcaaagcaag gugagaguga                                                   20


<210> 1204
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1204
uugcuaagua ggcugagauu ga                                                22


<210> 1205
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1205
ucaaucucag ccuacuuagc aa                                                22


<210> 1206
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1206
cacccccugu uuccuggccc ac                                                22


<210> 1207
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1207
gugggccagg aaacaggggg ug                                                22


<210> 1208
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1208
ugggccaggg agcagcuggu ggg                                               23


<210> 1209
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1209
cccaccagcu gcucccuggc cca                                               23


<210> 1210
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1210
ugcccaugcc auacuuuugc cuca                                              24


<210> 1211
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1211
ugaggcaaaa guauggcaug ggca                                              24


<210> 1212
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1212
auggcaucgu ccccuggugg cu                                                22


<210> 1213
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1213
agccaccagg ggacgaugcc au                                                22


<210> 1214
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1214
gacacaugac cauaaaugcu aa                                                22


<210> 1215
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1215
uuagcauuua uggucaugug uc                                                22


<210> 1216
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1216
uggagagaga aaagagacag aag                                               23


<210> 1217
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1217
cuucugucuc uuuucucucu cca                                               23


<210> 1218
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1218
agacaguagu ucuugccugg uu                                                22


<210> 1219
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1219
aaccaggcaa gaacuacugu cu                                                22


<210> 1220
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1220
accaggcaag aaauauugu                                                    19


<210> 1221
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1221
acaauauuuc uugccuggu                                                    19


<210> 1222
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1222
auugucccuc ucccuuccca g                                                 21


<210> 1223
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1223
cugggaaggg agagggacaa u                                                 21


<210> 1224
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1224
acugggaaga ggagcugagg ga                                                22


<210> 1225
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1225
ucccucagcu ccucuuccca gu                                                22


<210> 1226
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1226
gaagauggug cugugcugag gaa                                               23


<210> 1227
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1227
uuccucagca cagcaccauc uuc                                               23


<210> 1228
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1228
ugugggacug caaaugggag                                                   20


<210> 1229
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1229
cucccauuug cagucccaca                                                   20


<210> 1230
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1230
ucugaggccu gccucucccc a                                                 21


<210> 1231
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1231
uggggagagg caggccucag a                                                 21


<210> 1232
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1232
ugggcgaggg gugggcucuc agag                                              24


<210> 1233
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1233
cucugagagc ccaccccucg ccca                                              24


<210> 1234
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1234
agguagaaug aggccugaca u                                                 21


<210> 1235
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1235
augucaggcc ucauucuacc u                                                 21


<210> 1236
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1236
ucaggccucu uucuaccuu                                                    19


<210> 1237
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1237
aagguagaaa gaggccuga                                                    19


<210> 1238
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1238
cggggugggu gaggucgggc                                                   20


<210> 1239
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1239
gcccgaccuc acccaccccg                                                   20


<210> 1240
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1240
guucuguuaa cccauccccu ca                                                22


<210> 1241
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1241
ugaggggaug gguuaacaga ac                                                22


<210> 1242
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1242
aggggacugg uuaauagaac ua                                                22


<210> 1243
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1243
uaguucuauu aaccaguccc cu                                                22


<210> 1244
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1244
uggaguuaag gguugcuugg aga                                               23


<210> 1245
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1245
ucuccaagca acccuuaacu cca                                               23


<210> 1246
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1246
ucucugagca aggcuuaaca cc                                                22


<210> 1247
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1247
gguguuaagc cuugcucaga ga                                                22


<210> 1248
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1248
ugugggaucu ggaggcaucu gg                                                22


<210> 1249
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1249
ccagaugccu ccagauccca ca                                                22


<210> 1250
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1250
acccucguca gguccccggg g                                                 21


<210> 1251
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1251
ccccggggac cugacgaggg u                                                 21


<210> 1252
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1252
caccggggau ggcagagggu cg                                                22


<210> 1253
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1253
cgacccucug ccauccccgg ug                                                22


<210> 1254
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1254
ugggcugagg gcaggaggcc ugu                                               23


<210> 1255
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1255
acaggccucc ugcccucagc cca                                               23


<210> 1256
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1256
aauguggaag uggucugagg cau                                               23


<210> 1257
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1257
augccucaga ccacuuccac auu                                               23


<210> 1258
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1258
gugagugugg auccuggagg aau                                               23


<210> 1259
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1259
auuccuccag gauccacacu cac                                               23


<210> 1260
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1260
uuucuucuua gacauggcaa cg                                                22


<210> 1261
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1261
cguugccaug ucuaagaaga aa                                                22


<210> 1262
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1262
cugccauguc uaagaagaaa ac                                                22


<210> 1263
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1263
guuuucuucu uagacauggc ag                                                22


<210> 1264
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1264
uuucuucuua gacauggcag cu                                                22


<210> 1265
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1265
agcugccaug ucuaagaaga aa                                                22


<210> 1266
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1266
uugccauguc uaagaagaa                                                    19


<210> 1267
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1267
uucuucuuag acauggcaa                                                    19


<210> 1268
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1268
ugcagcucug guggaaaaug gag                                               23


<210> 1269
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1269
cuccauuuuc caccagagcu gca                                               23


<210> 1270
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1270
caggauccac agagcuaguc ca                                                22


<210> 1271
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1271
uggacuagcu cuguggaucc ug                                                22


<210> 1272
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1272
aacuagcucu guggauccug ac                                                22


<210> 1273
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1273
gucaggaucc acagagcuag uu                                                22


<210> 1274
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1274
aaagauggac aauuggcuaa au                                                22


<210> 1275
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1275
auuuagccaa uuguccaucu uu                                                22


<210> 1276
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1276
agcugagcuc cauggacgug cagu                                              24


<210> 1277
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1277
acugcacguc cauggagcuc agcu                                              24


<210> 1278
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1278
cuuccggucu gugagccccg uc                                                22


<210> 1279
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1279
gacggggcuc acagaccgga ag                                                22


<210> 1280
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1280
uggggugccc acuccgcaag uu                                                22


<210> 1281
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1281
aacuugcgga gugggcaccc ca                                                22


<210> 1282
<211> 26
<212> RNA
<213> Homo sapiens

<400> 1282
cucggccgcg gcgcguagcc cccgcc                                            26


<210> 1283
<211> 26
<212> RNA
<213> Homo sapiens

<400> 1283
ggcgggggcu acgcgccgcg gccgag                                            26


<210> 1284
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1284
cugggggacg cgugagcgcg agc                                               23


<210> 1285
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1285
gcucgcgcuc acgcgucccc cag                                               23


<210> 1286
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1286
cauacaaucu gacauguauu u                                                 21


<210> 1287
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1287
aaauacaugu cagauuguau g                                                 21


<210> 1288
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1288
auacauguca gauuguaugc c                                                 21


<210> 1289
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1289
ggcauacaau cugacaugua u                                                 21


<210> 1290
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1290
ucccuccuuc uguccccaca g                                                 21


<210> 1291
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1291
cuguggggac agaaggaggg a                                                 21


<210> 1292
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1292
acuggggagc agaaggagaa cc                                                22


<210> 1293
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1293
gguucuccuu cugcucccca gu                                                22


<210> 1294
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1294
gaaaauccuu uuuguuuuuc cag                                               23


<210> 1295
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1295
cuggaaaaac aaaaaggauu uuc                                               23


<210> 1296
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1296
agggaaaaaa aaaaggauuu guc                                               23


<210> 1297
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1297
gacaaauccu uuuuuuuuuc ccu                                               23


<210> 1298
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1298
uguguccggg aaguggagga gg                                                22


<210> 1299
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1299
ccuccuccac uucccggaca ca                                                22


<210> 1300
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1300
ugaaguuaca ucauggucgc uu                                                22


<210> 1301
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1301
aagcgaccau gauguaacuu ca                                                22


<210> 1302
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1302
aagcgaccau gauguaacuu ca                                                22


<210> 1303
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1303
ugaaguuaca ucauggucgc uu                                                22


<210> 1304
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1304
uuagugcaua gucuuugguc u                                                 21


<210> 1305
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1305
agaccaaaga cuaugcacua a                                                 21


<210> 1306
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1306
accgaagacu gugcgcuaau cu                                                22


<210> 1307
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1307
agauuagcgc acagucuucg gu                                                22


<210> 1308
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1308
uuacacagcu ggacagaggc a                                                 21


<210> 1309
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1309
ugccucuguc cagcugugua a                                                 21


<210> 1310
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1310
uccaggcagg agccggacug ga                                                22


<210> 1311
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1311
uccaguccgg cuccugccug ga                                                22


<210> 1312
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1312
cugggcucgg gacgcgcggc u                                                 21


<210> 1313
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1313
agccgcgcgu cccgagccca g                                                 21


<210> 1314
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1314
ggggcuguga uugaccagca gg                                                22


<210> 1315
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1315
ccugcugguc aaucacagcc cc                                                22


<210> 1316
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1316
cacuguuuca ccacuggcuc uu                                                22


<210> 1317
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1317
aagagccagu ggugaaacag ug                                                22


<210> 1318
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1318
gagccagugg ugagacagug a                                                 21


<210> 1319
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1319
ucacugucuc accacuggcu c                                                 21


<210> 1320
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1320
aagguauugu ucagacuuau ga                                                22


<210> 1321
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1321
ucauaagucu gaacaauacc uu                                                22


<210> 1322
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1322
ucugugauag agauucuuug cu                                                22


<210> 1323
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1323
agcaaagaau cucuaucaca ga                                                22


<210> 1324
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1324
ucugaauugu aagaguuguu a                                                 21


<210> 1325
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1325
uaacaacucu uacaauucag a                                                 21


<210> 1326
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1326
agaacucuug cagucuuaga ugu                                               23


<210> 1327
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1327
acaucuaaga cugcaagagu ucu                                               23


<210> 1328
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1328
aacgggaaug caggcuguau cu                                                22


<210> 1329
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1329
agauacagcc ugcauucccg uu                                                22


<210> 1330
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1330
ucugaguucc uggagccugg ucu                                               23


<210> 1331
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1331
agaccaggcu ccaggaacuc aga                                               23


<210> 1332
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1332
uggagaucca gugcucgccc gau                                               23


<210> 1333
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1333
aucgggcgag cacuggaucu cca                                               23


<210> 1334
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1334
uguugcaagu cgguggagac gu                                                22


<210> 1335
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1335
acgucuccac cgacuugcaa ca                                                22


<210> 1336
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1336
cucucuacug acuugcaaca ua                                                22


<210> 1337
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1337
uauguugcaa gucaguagag ag                                                22


<210> 1338
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1338
ucucccuucc ugcccuggcu ag                                                22


<210> 1339
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1339
cuagccaggg caggaaggga ga                                                22


<210> 1340
<211> 26
<212> RNA
<213> Homo sapiens

<400> 1340
cccagggcuu ggaguggggc aagguu                                            26


<210> 1341
<211> 26
<212> RNA
<213> Homo sapiens

<400> 1341
aaccuugccc cacuccaagc ccuggg                                            26


<210> 1342
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1342
uaucugcugg gcuuucuggu guu                                               23


<210> 1343
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1343
aacaccagaa agcccagcag aua                                               23


<210> 1344
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1344
uggcuguugg agggggcagg c                                                 21


<210> 1345
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1345
gccugccccc uccaacagcc a                                                 21


<210> 1346
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1346
cagcccuccu cccgcaccca aa                                                22


<210> 1347
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1347
uuugggugcg ggaggagggc ug                                                22


<210> 1348
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1348
uaggggcagc agaggaccug gg                                                22


<210> 1349
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1349
cccagguccu cugcugcccc ua                                                22


<210> 1350
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1350
uugaggagac augguggggg cc                                                22


<210> 1351
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1351
ggcccccacc augucuccuc aa                                                22


<210> 1352
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1352
gcagcccagc ugaggccucu g                                                 21


<210> 1353
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1353
cagaggccuc agcugggcug c                                                 21


<210> 1354
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1354
gagcaggcga ggcugggcug aa                                                22


<210> 1355
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1355
uucagcccag ccucgccugc uc                                                22


<210> 1356
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1356
ccagccacgg acugagagug cau                                               23


<210> 1357
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1357
augcacucuc aguccguggc ugg                                               23


<210> 1358
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1358
guccuccagg ccaugagcug cgg                                               23


<210> 1359
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1359
ccgcagcuca uggccuggag gac                                               23


<210> 1360
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1360
ucaggcagug uggguaucag au                                                22


<210> 1361
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1361
aucugauacc cacacugccu ga                                                22


<210> 1362
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1362
ugagagugga auucacagua uuu                                               23


<210> 1363
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1363
aaauacugug aauuccacuc uca                                               23


<210> 1364
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1364
auacugugaa uuucacuguc aca                                               23


<210> 1365
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1365
ugugacagug aaauucacag uau                                               23


<210> 1366
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1366
caaauggaca ggauaacacc u                                                 21


<210> 1367
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1367
agguguuauc cuguccauuu g                                                 21


<210> 1368
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1368
agguguuauc cuauccauuu gc                                                22


<210> 1369
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1369
gcaaauggau aggauaacac cu                                                22


<210> 1370
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1370
ugaucucacc gcugccuccu uc                                                22


<210> 1371
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1371
gaaggaggca gcggugagau ca                                                22


<210> 1372
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1372
caggaggcag ugggcgagca gg                                                22


<210> 1373
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1373
ccugcucgcc cacugccucc ug                                                22


<210> 1374
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1374
ugcaagacgg auacugucau cu                                                22


<210> 1375
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1375
agaugacagu auccgucuug ca                                                22


<210> 1376
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1376
ugucagugac uccugccccu uggu                                              24


<210> 1377
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1377
accaaggggc aggagucacu gaca                                              24


<210> 1378
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1378
agggggcgca gucacugacg ug                                                22


<210> 1379
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1379
cacgucagug acugcgcccc cu                                                22


<210> 1380
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1380
ucaaaaugua gaggaagacc cca                                               23


<210> 1381
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1381
uggggucuuc cucuacauuu uga                                               23


<210> 1382
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1382
aauuuacucu gcaaucuucu cc                                                22


<210> 1383
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1383
ggagaagauu gcagaguaaa uu                                                22


<210> 1384
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1384
agaagauugc agaguaaguu cc                                                22


<210> 1385
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1385
ggaacuuacu cugcaaucuu cu                                                22


<210> 1386
<211> 26
<212> RNA
<213> Homo sapiens

<400> 1386
cacaggacug acuccucacc ccagug                                            26


<210> 1387
<211> 26
<212> RNA
<213> Homo sapiens

<400> 1387
cacuggggug aggagucagu ccugug                                            26


<210> 1388
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1388
ucuggggaug aggacagugu gu                                                22


<210> 1389
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1389
acacacuguc cucaucccca ga                                                22


<210> 1390
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1390
augggugaug gguguggugu                                                   20


<210> 1391
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1391
acaccacacc caucacccau                                                   20


<210> 1392
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1392
uuggccacca caccuacccc uu                                                22


<210> 1393
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1393
aagggguagg ugugguggcc aa                                                22


<210> 1394
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1394
uguaguugua uuguauugcc ac                                                22


<210> 1395
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1395
guggcaauac aauacaacua ca                                                22


<210> 1396
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1396
uagcaauaca guacaaauau agu                                               23


<210> 1397
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1397
acuauauuug uacuguauug cua                                               23


<210> 1398
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1398
ucagucacau aucuaguguc ua                                                22


<210> 1399
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1399
uagacacuag auaugugacu ga                                                22


<210> 1400
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1400
gacacuaggc augugaguga uu                                                22


<210> 1401
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1401
aaucacucac augccuagug uc                                                22


<210> 1402
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1402
ucaaucacuu gguaauugcu gu                                                22


<210> 1403
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1403
acagcaauua ccaagugauu ga                                                22


<210> 1404
<211> 25
<212> RNA
<213> Homo sapiens

<400> 1404
agcggggagg aagugggcgc ugcuu                                             25


<210> 1405
<211> 25
<212> RNA
<213> Homo sapiens

<400> 1405
aagcagcgcc cacuuccucc ccgcu                                             25


<210> 1406
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1406
agcccgcccc agccgagguu cu                                                22


<210> 1407
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1407
agaaccucgg cuggggcggg cu                                                22


<210> 1408
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1408
gccccggcgc gggcggguuc ugg                                               23


<210> 1409
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1409
ccagaacccg cccgcgccgg ggc                                               23


<210> 1410
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1410
agcaaggcgg caucucucug au                                                22


<210> 1411
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1411
aucagagaga ugccgccuug cu                                                22


<210> 1412
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1412
agagaugccg ccuugcuccu u                                                 21


<210> 1413
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1413
aaggagcaag gcggcaucuc u                                                 21


<210> 1414
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1414
uugaagagga ggugcucugu agc                                               23


<210> 1415
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1415
gcuacagagc accuccucuu caa                                               23


<210> 1416
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1416
acaacaguga cuugcucucc aa                                                22


<210> 1417
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1417
uuggagagca agucacuguu gu                                                22


<210> 1418
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1418
gggugagggc aggugguu                                                     18


<210> 1419
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1419
aaccaccugc ccucaccc                                                     18


<210> 1420
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1420
cgugucuucu ggcuugau                                                     18


<210> 1421
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1421
aucaagccag aagacacg                                                     18


<210> 1422
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1422
ugcaucaggc cagaagacau gag                                               23


<210> 1423
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1423
cucaugucuu cuggccugau gca                                               23


<210> 1424
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1424
aaugagagac cuguacugua u                                                 21


<210> 1425
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1425
auacaguaca ggucucucau u                                                 21


<210> 1426
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1426
uccaguacag gucucucauu uc                                                22


<210> 1427
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1427
gaaaugagag accuguacug ga                                                22


<210> 1428
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1428
ugggauccag acagugggag aa                                                22


<210> 1429
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1429
uucucccacu gucuggaucc ca                                                22


<210> 1430
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1430
uucucccacu accaggcucc ca                                                22


<210> 1431
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1431
ugggagccug guagugggag aa                                                22


<210> 1432
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1432
ccaaccuagg uggucagagu ug                                                22


<210> 1433
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1433
caacucugac caccuagguu gg                                                22


<210> 1434
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1434
aacucugacc ccuuagguug au                                                22


<210> 1435
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1435
aucaaccuaa ggggucagag uu                                                22


<210> 1436
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1436
gugccaccuu aacugcagcc aau                                               23


<210> 1437
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1437
auuggcugca guuaaggugg cac                                               23


<210> 1438
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1438
aaguuggcug caguuaaggu gg                                                22


<210> 1439
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1439
ccaccuuaac ugcagccaac uu                                                22


<210> 1440
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1440
aagggggaag gaaacaugga ga                                                22


<210> 1441
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1441
ucuccauguu uccuuccccc uu                                                22


<210> 1442
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1442
uccauguuuc cuucccccuu cu                                                22


<210> 1443
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1443
agaaggggga aggaaacaug ga                                                22


<210> 1444
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1444
acacaugggu ggcuguggcc u                                                 21


<210> 1445
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1445
aggccacagc cacccaugug u                                                 21


<210> 1446
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1446
uaggccacag ccacccaugu gu                                                22


<210> 1447
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1447
acacaugggu ggcuguggcc ua                                                22


<210> 1448
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1448
agcuguaccu gaaaccaagc a                                                 21


<210> 1449
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1449
ugcuugguuu cagguacagc u                                                 21


<210> 1450
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1450
ucacaaaucu auaauaugca gg                                                22


<210> 1451
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1451
ccugcauauu auagauuugu ga                                                22


<210> 1452
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1452
ugcuuaaguu guaccaagua u                                                 21


<210> 1453
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1453
auacuuggua caacuuaagc a                                                 21


<210> 1454
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1454
ccuggcauau uugguauaac uu                                                22


<210> 1455
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1455
aaguuauacc aaauaugcca gg                                                22


<210> 1456
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1456
ugagggcucc aggugacggu gg                                                22


<210> 1457
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1457
ccaccgucac cuggagcccu ca                                                22


<210> 1458
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1458
accugccagc accucccugc ag                                                22


<210> 1459
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1459
cugcagggag gugcuggcag gu                                                22


<210> 1460
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1460
ggcaggaggg cugugccagg uug                                               23


<210> 1461
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1461
caaccuggca cagcccuccu gcc                                               23


<210> 1462
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1462
cccucucugg cuccucccca aa                                                22


<210> 1463
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1463
uuuggggagg agccagagag gg                                                22


<210> 1464
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1464
ugggggagcc augagauaag agca                                              24


<210> 1465
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1465
ugcucuuauc ucauggcucc ccca                                              24


<210> 1466
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1466
guaccuucug guucagcuag u                                                 21


<210> 1467
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1467
acuagcugaa ccagaaggua c                                                 21


<210> 1468
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1468
aacugaacca ggagugagcu ucg                                               23


<210> 1469
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1469
cgaagcucac uccugguuca guu                                               23


<210> 1470
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1470
uggggaaggc gucagugucg gg                                                22


<210> 1471
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1471
cccgacacug acgccuuccc ca                                                22


<210> 1472
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1472
agacccugca gccuucccac c                                                 21


<210> 1473
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1473
ggugggaagg cugcaggguc u                                                 21


<210> 1474
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1474
acccagguuc ccucuggccg ca                                                22


<210> 1475
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1475
ugcggccaga gggaaccugg gu                                                22


<210> 1476
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1476
agggccagag gagccuggag ugg                                               23


<210> 1477
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1477
ccacuccagg cuccucuggc ccu                                               23


<210> 1478
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1478
auagugggaa gcuggcagau uc                                                22


<210> 1479
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1479
gaaucugcca gcuucccacu au                                                22


<210> 1480
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1480
aucugccagc uuccacagug g                                                 21


<210> 1481
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1481
ccacugugga agcuggcaga u                                                 21


<210> 1482
<211> 25
<212> RNA
<213> Homo sapiens

<400> 1482
caugcugacc ucccuccugc cccag                                             25


<210> 1483
<211> 25
<212> RNA
<213> Homo sapiens

<400> 1483
cuggggcagg agggagguca gcaug                                             25


<210> 1484
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1484
ugggagggga gaggcagcaa gca                                               23


<210> 1485
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1485
ugcuugcugc cucuccccuc cca                                               23


<210> 1486
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1486
ucauuuaucu guugggaagc ua                                                22


<210> 1487
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1487
uagcuuccca acagauaaau ga                                                22


<210> 1488
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1488
cuggcggagc ccauuccaug cca                                               23


<210> 1489
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1489
uggcauggaa ugggcuccgc cag                                               23


<210> 1490
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1490
cacacaagug gcccccaaca cu                                                22


<210> 1491
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1491
aguguugggg gccacuugug ug                                                22


<210> 1492
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1492
ugcugggggc cacaugagug ug                                                22


<210> 1493
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1493
cacacucaug uggcccccag ca                                                22


<210> 1494
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1494
gcccugaccu guccuguucu g                                                 21


<210> 1495
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1495
cagaacagga caggucaggg c                                                 21


<210> 1496
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1496
uguagagcag ggagcaggaa gcu                                               23


<210> 1497
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1497
agcuuccugc ucccugcucu aca                                               23


<210> 1498
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1498
ccaccagguc uagcauuggg au                                                22


<210> 1499
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1499
aucccaaugc uagaccuggu gg                                                22


<210> 1500
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1500
aaucccaaug cuagacccgg ug                                                22


<210> 1501
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1501
caccgggucu agcauuggga uu                                                22


<210> 1502
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1502
gcugcgggcu gcggucaggg cg                                                22


<210> 1503
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1503
cgcccugacc gcagcccgca gc                                                22


<210> 1504
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1504
aaaggugcuc aaauuagaca u                                                 21


<210> 1505
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1505
augucuaauu ugagcaccuu u                                                 21


<210> 1506
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1506
ccuaauuuga acaccuucgg ua                                                22


<210> 1507
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1507
uaccgaaggu guucaaauua gg                                                22


<210> 1508
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1508
aggcagguua ucugggcug                                                    19


<210> 1509
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1509
cagcccagau aaccugccu                                                    19


<210> 1510
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1510
augcgaggau gcugacagug                                                   20


<210> 1511
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1511
cacugucagc auccucgcau                                                   20


<210> 1512
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1512
ugaaacugga gcgccuggag ga                                                22


<210> 1513
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1513
uccuccaggc gcuccaguuu ca                                                22


<210> 1514
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1514
accagcgcgu uuucaguuuc au                                                22


<210> 1515
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1515
augaaacuga aaacgcgcug gu                                                22


<210> 1516
<211> 25
<212> RNA
<213> Homo sapiens

<400> 1516
aagggaggag gagcggaggg gcccu                                             25


<210> 1517
<211> 25
<212> RNA
<213> Homo sapiens

<400> 1517
agggccccuc cgcuccuccu cccuu                                             25


<210> 1518
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1518
gcccgagagg auccgucccu gc                                                22


<210> 1519
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1519
gcagggacgg auccucucgg gc                                                22


<210> 1520
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1520
aggacugauc cucucgggca gg                                                22


<210> 1521
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1521
ccugcccgag aggaucaguc cu                                                22


<210> 1522
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1522
ucaggcaaag ggauauuuac aga                                               23


<210> 1523
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1523
ucuguaaaua ucccuuugcc uga                                               23


<210> 1524
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1524
uuucugucuu uucuggucca g                                                 21


<210> 1525
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1525
cuggaccaga aaagacagaa a                                                 21


<210> 1526
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1526
uggccggaug ggacaggagg cau                                               23


<210> 1527
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1527
augccuccug ucccauccgg cca                                               23


<210> 1528
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1528
ucuaaagacu agacuucgcu aug                                               23


<210> 1529
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1529
cauagcgaag ucuagucuuu aga                                               23


<210> 1530
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1530
uggcccggcg acgucucacg guc                                               23


<210> 1531
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1531
gaccgugaga cgucgccggg cca                                               23


<210> 1532
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1532
ugaguggggc ucccgggacg gcg                                               23


<210> 1533
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1533
cgccgucccg ggagccccac uca                                               23


<210> 1534
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1534
agcggugcuc cugcgggccg a                                                 21


<210> 1535
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1535
ucggcccgca ggagcaccgc u                                                 21


<210> 1536
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1536
ccggucccag gagaaccugc aga                                               23


<210> 1537
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1537
ucugcagguu cuccugggac cgg                                               23


<210> 1538
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1538
aaggcccggg cuuuccuccc ag                                                22


<210> 1539
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1539
cugggaggaa agcccgggcc uu                                                22


<210> 1540
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1540
agggaaggag gcuuggucuu ag                                                22


<210> 1541
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1541
cuaagaccaa gccuccuucc cu                                                22


<210> 1542
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1542
gagguuuggg gaggauuugc u                                                 21


<210> 1543
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1543
agcaaauccu ccccaaaccu c                                                 21


<210> 1544
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1544
cgccccuccu gcccccacag                                                   20


<210> 1545
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1545
cugugggggc aggaggggcg                                                   20


<210> 1546
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1546
ugcggggaca ggccagggca uc                                                22


<210> 1547
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1547
gaugcccugg ccuguccccg ca                                                22


<210> 1548
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1548
ccugacccac ccccucccgc ag                                                22


<210> 1549
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1549
cugcgggagg ggguggguca gg                                                22


<210> 1550
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1550
cucgggcgga ggugguugag ug                                                22


<210> 1551
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1551
cacucaacca ccuccgcccg ag                                                22


<210> 1552
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1552
agaggacccg uagcugcuag aagg                                              24


<210> 1553
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1553
ccuucuagca gcuacggguc cucu                                              24


<210> 1554
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1554
uuguggaucu caaggaugug cu                                                22


<210> 1555
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1555
agcacauccu ugagauccac aa                                                22


<210> 1556
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1556
uucucuuucu uuagccuugu gu                                                22


<210> 1557
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1557
acacaaggcu aaagaaagag aa                                                22


<210> 1558
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1558
caaggccaaa ggaagagaac ag                                                22


<210> 1559
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1559
cuguucucuu ccuuuggccu ug                                                22


<210> 1560
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1560
augcggaccu ggguuagcgg agu                                               23


<210> 1561
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1561
acuccgcuaa cccagguccg cau                                               23


<210> 1562
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1562
agccaggcuc ugaagggaaa gu                                                22


<210> 1563
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1563
acuuucccuu cagagccugg cu                                                22


<210> 1564
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1564
uuucccuuca gagccuggcu uu                                                22


<210> 1565
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1565
aaagccaggc ucugaaggga aa                                                22


<210> 1566
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1566
ccagagaugg uugccuuccu au                                                22


<210> 1567
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1567
auaggaaggc aaccaucucu gg                                                22


<210> 1568
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1568
cagggaggcg cucacucucu gcu                                               23


<210> 1569
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1569
agcagagagu gagcgccucc cug                                               23


<210> 1570
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1570
caugacguca cagaggcuuc gc                                                22


<210> 1571
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1571
gcgaagccuc ugugacguca ug                                                22


<210> 1572
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1572
aggccucugu gacgucacgg ugu                                               23


<210> 1573
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1573
acaccgugac gucacagagg ccu                                               23


<210> 1574
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1574
ugccccaccu gcugaccacc cuc                                               23


<210> 1575
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1575
gagggugguc agcagguggg gca                                               23


<210> 1576
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1576
gugaguggga gccggugggg cug                                               23


<210> 1577
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1577
cagccccacc ggcucccacu cac                                               23


<210> 1578
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1578
uaggacuaga uguuggaauu a                                                 21


<210> 1579
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1579
uaauuccaac aucuaguccu a                                                 21


<210> 1580
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1580
aaauucaugu ucaaucuaaa cc                                                22


<210> 1581
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1581
gguuuagauu gaacaugaau uu                                                22


<210> 1582
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1582
uuuagauuga acaugaaguu ag                                                22


<210> 1583
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1583
cuaacuucau guucaaucua aa                                                22


<210> 1584
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1584
gagggcaugc gcacuuuguc c                                                 21


<210> 1585
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1585
ggacaaagug cgcaugcccu c                                                 21


<210> 1586
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1586
acaaggugug caugccugac c                                                 21


<210> 1587
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1587
ggucaggcau gcacaccuug u                                                 21


<210> 1588
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1588
cuucugauca agauuugugg ug                                                22


<210> 1589
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1589
caccacaaau cuugaucaga ag                                                22


<210> 1590
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1590
ccaaaucuug aucagaagcc u                                                 21


<210> 1591
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1591
aggcuucuga ucaagauuug g                                                 21


<210> 1592
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1592
aggcaggggc uggugcuggg cggg                                              24


<210> 1593
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1593
cccgcccagc accagccccu gccu                                              24


<210> 1594
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1594
cgccugccca gcccuccugc u                                                 21


<210> 1595
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1595
agcaggaggg cugggcaggc g                                                 21


<210> 1596
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1596
uuaacuccuu ucacacccau gg                                                22


<210> 1597
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1597
ccaugggugu gaaaggaguu aa                                                22


<210> 1598
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1598
uggaugugga aggaguuauc u                                                 21


<210> 1599
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1599
agauaacucc uuccacaucc a                                                 21


<210> 1600
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1600
ugagugauug auagcuaugu uc                                                22


<210> 1601
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1601
gaacauagcu aucaaucacu ca                                                22


<210> 1602
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1602
auagcaauug cucuuuugga a                                                 21


<210> 1603
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1603
uuccaaaaga gcaauugcua u                                                 21


<210> 1604
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1604
ucugaaagag caguuggugu u                                                 21


<210> 1605
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1605
aacaccaacu gcucuuucag a                                                 21


<210> 1606
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1606
cgcgggcgcu ccuggccgcc gcc                                               23


<210> 1607
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1607
ggcggcggcc aggagcgccc gcg                                               23


<210> 1608
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1608
ccaggagauc cagagagaau                                                   20


<210> 1609
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1609
auucucucug gaucuccugg                                                   20


<210> 1610
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1610
auucucucug gaucccaugg au                                                22


<210> 1611
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1611
auccauggga uccagagaga au                                                22


<210> 1612
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1612
ucugccaucc ucccuccccu ac                                                22


<210> 1613
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1613
guaggggagg gaggauggca ga                                                22


<210> 1614
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1614
ggugggaugg agagaaggua ugag                                              24


<210> 1615
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1615
cucauaccuu cucuccaucc cacc                                              24


<210> 1616
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1616
ugagaugaca cuguagcu                                                     18


<210> 1617
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1617
agcuacagug ucaucuca                                                     18


<210> 1618
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1618
agcagacuug accuacaauu a                                                 21


<210> 1619
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1619
uaauuguagg ucaagucugc u                                                 21


<210> 1620
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1620
cagaacagga gcauagaaag gc                                                22


<210> 1621
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1621
gccuuucuau gcuccuguuc ug                                                22


<210> 1622
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1622
uuaauuuuuu guuucgguca cu                                                22


<210> 1623
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1623
agugaccgaa acaaaaaauu aa                                                22


<210> 1624
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1624
cuugccaucc ugguccacug cau                                               23


<210> 1625
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1625
augcagugga ccaggauggc aag                                               23


<210> 1626
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1626
guggaccagg auggcaaggg cu                                                22


<210> 1627
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1627
agcccuugcc auccuggucc ac                                                22


<210> 1628
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1628
auaccucauc uagaaugcug ua                                                22


<210> 1629
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1629
uacagcauuc uagaugaggu au                                                22


<210> 1630
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1630
uucuagauga gagauauaua ua                                                22


<210> 1631
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1631
uauauauauc ucucaucuag aa                                                22


<210> 1632
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1632
ucuucuuccu uugcagaguu ga                                                22


<210> 1633
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1633
ucaacucugc aaaggaagaa ga                                                22


<210> 1634
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1634
aauucuguaa aggaagaaga gg                                                22


<210> 1635
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1635
ccucuucuuc cuuuacagaa uu                                                22


<210> 1636
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1636
uaggagggaa uaguaaaagc ag                                                22


<210> 1637
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1637
cugcuuuuac uauucccucc ua                                                22


<210> 1638
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1638
acccuugagc cugaucccua gc                                                22


<210> 1639
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1639
gcuagggauc aggcucaagg gu                                                22


<210> 1640
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1640
aauguuggaa uccucgcuag ag                                                22


<210> 1641
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1641
cucuagcgag gauuccaaca uu                                                22


<210> 1642
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1642
uagcggggau uccaauauug g                                                 21


<210> 1643
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1643
ccaauauugg aauccccgcu a                                                 21


<210> 1644
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1644
ugauugucuu cauaucuaga ac                                                22


<210> 1645
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1645
guucuagaua ugaagacaau ca                                                22


<210> 1646
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1646
uucuggauau gaagacaauc aa                                                22


<210> 1647
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1647
uugauugucu ucauauccag aa                                                22


<210> 1648
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1648
ccccgguguu ggggcgcguc ugc                                               23


<210> 1649
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1649
gcagacgcgc cccaacaccg ggg                                               23


<210> 1650
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1650
ggcgcgccca gcucccgggc u                                                 21


<210> 1651
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1651
agcccgggag cugggcgcgc c                                                 21


<210> 1652
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1652
ugaggagaug cugggacuga                                                   20


<210> 1653
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1653
ucagucccag caucuccuca                                                   20


<210> 1654
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1654
agagucggcg acgccgccag c                                                 21


<210> 1655
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1655
gcuggcggcg ucgccgacuc u                                                 21


<210> 1656
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1656
ugaagccagc ucuggucugg gc                                                22


<210> 1657
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1657
gcccagacca gagcuggcuu ca                                                22


<210> 1658
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1658
ugagaccagg acuggaugca cc                                                22


<210> 1659
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1659
ggugcaucca guccuggucu ca                                                22


<210> 1660
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1660
gaugcgccgc ccacugcccc gcgc                                              24


<210> 1661
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1661
gcgcggggca gugggcggcg cauc                                              24


<210> 1662
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1662
gcgggggugg cggcggcauc cc                                                22


<210> 1663
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1663
gggaugccgc cgccaccccc gc                                                22


<210> 1664
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1664
uuacggacca gcuaagggag gc                                                22


<210> 1665
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1665
gccucccuua gcugguccgu aa                                                22


<210> 1666
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1666
cacacauagc agguguauau a                                                 21


<210> 1667
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1667
uauauacacc ugcuaugugu g                                                 21


<210> 1668
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1668
guauacaccu gauaugugua ug                                                22


<210> 1669
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1669
cauacacaua ucagguguau ac                                                22


<210> 1670
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1670
ugaaugguaa agcgauguca ca                                                22


<210> 1671
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1671
ugugacaucg cuuuaccauu ca                                                22


<210> 1672
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1672
aucgcuuuac cauucauguu                                                   20


<210> 1673
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1673
aacaugaaug guaaagcgau                                                   20


<210> 1674
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1674
uggauaugau gacugaaa                                                     18


<210> 1675
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1675
uuucagucau cauaucca                                                     18


<210> 1676
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1676
cggugagcgc ucgcuggc                                                     18


<210> 1677
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1677
gccagcgagc gcucaccg                                                     18


<210> 1678
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1678
ucugcacugu gaguuggcug gcu                                               23


<210> 1679
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1679
agccagccaa cucacagugc aga                                               23


<210> 1680
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1680
acauccugcu ccacagggca gagg                                              24


<210> 1681
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1681
ccucugcccu guggagcagg augu                                              24


<210> 1682
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1682
ucuggcuauc ucacgagacu gu                                                22


<210> 1683
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1683
acagucucgu gagauagcca ga                                                22


<210> 1684
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1684
auauuauuag ccacuucugg au                                                22


<210> 1685
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1685
auccagaagu ggcuaauaau au                                                22


<210> 1686
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1686
agaaguggcu aauaauauug a                                                 21


<210> 1687
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1687
ucaauauuau uagccacuuc u                                                 21


<210> 1688
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1688
uaaaguggca gaguauagac ac                                                22


<210> 1689
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1689
gugucuauac ucugccacuu ua                                                22


<210> 1690
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1690
ugucuauacu cugucacuuu ac                                                22


<210> 1691
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1691
guaaagugac agaguauaga ca                                                22


<210> 1692
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1692
ucucaguaag uggcacucug u                                                 21


<210> 1693
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1693
acagagugcc acuuacugag a                                                 21


<210> 1694
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1694
gacagagugc cacuuacuga a                                                 21


<210> 1695
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1695
uucaguaagu ggcacucugu c                                                 21


<210> 1696
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1696
aacucacgaa guauaccgaa gu                                                22


<210> 1697
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1697
acuucgguau acuucgugag uu                                                22


<210> 1698
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1698
uucgguauac uuugugaauu gg                                                22


<210> 1699
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1699
ccaauucaca aaguauaccg aa                                                22


<210> 1700
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1700
acuggcaugc ugcauuuaua ua                                                22


<210> 1701
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1701
uauauaaaug cagcaugcca gu                                                22


<210> 1702
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1702
aucuaaaugc agcaugccag uc                                                22


<210> 1703
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1703
gacuggcaug cugcauuuag au                                                22


<210> 1704
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1704
cauccguccg ucuguccac                                                    19


<210> 1705
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1705
guggacagac ggacggaug                                                    19


<210> 1706
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1706
aguggaccga ggaaggaagg a                                                 21


<210> 1707
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1707
uccuuccuuc cucgguccac u                                                 21


<210> 1708
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1708
uacacaagaa aaccaaggcu ca                                                22


<210> 1709
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1709
ugagccuugg uuuucuugug ua                                                22


<210> 1710
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1710
uaacauaaua guguggauug a                                                 21


<210> 1711
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1711
ucaauccaca cuauuauguu a                                                 21


<210> 1712
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1712
ugcuuaaccu ugcccucgaa a                                                 21


<210> 1713
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1713
uuucgagggc aagguuaagc a                                                 21


<210> 1714
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1714
uuggacggua agguuaagca a                                                 21


<210> 1715
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1715
uugcuuaacc uuaccgucca a                                                 21


<210> 1716
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1716
aaaagcauca ggaaguaccc a                                                 21


<210> 1717
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1717
uggguacuuc cugaugcuuu u                                                 21


<210> 1718
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1718
gcaggacagg cagaagugga u                                                 21


<210> 1719
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1719
auccacuucu gccuguccug c                                                 21


<210> 1720
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1720
cagggcuggc agugacaugg gu                                                22


<210> 1721
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1721
acccauguca cugccagccc ug                                                22


<210> 1722
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1722
auuucccugc cauucccuug gc                                                22


<210> 1723
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1723
gccaagggaa uggcagggaa au                                                22


<210> 1724
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1724
uggcggcggu aguuaugggc uu                                                22


<210> 1725
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1725
aagcccauaa cuaccgccgc ca                                                22


<210> 1726
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1726
gcucccucua gggucgcucg ga                                                22


<210> 1727
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1727
uccgagcgac ccuagaggga gc                                                22


<210> 1728
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1728
ugggaacuua guagagguuu aa                                                22


<210> 1729
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1729
uuaaaccucu acuaaguucc ca                                                22


<210> 1730
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1730
uggggcuagu gaugcaggac g                                                 21


<210> 1731
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1731
cguccugcau cacuagcccc a                                                 21


<210> 1732
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1732
gcugacagca gggcuggccg cu                                                22


<210> 1733
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1733
agcggccagc ccugcuguca gc                                                22


<210> 1734
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1734
auuggacugc ugauggcccg u                                                 21


<210> 1735
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1735
acgggccauc agcaguccaa u                                                 21


<210> 1736
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1736
aggccaucag caguccaaug aa                                                22


<210> 1737
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1737
uucauuggac ugcugauggc cu                                                22


<210> 1738
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1738
uuggacagaa aacacgcagg aa                                                22


<210> 1739
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1739
uuccugcgug uuuucugucc aa                                                22


<210> 1740
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1740
ccugcguguu uucuguccaa                                                   20


<210> 1741
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1741
uuggacagaa aacacgcagg                                                   20


<210> 1742
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1742
ugagacaggc uuaugcugcu au                                                22


<210> 1743
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1743
auagcagcau aagccugucu ca                                                22


<210> 1744
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1744
auagcagcau gaaccugucu ca                                                22


<210> 1745
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1745
ugagacaggu ucaugcugcu au                                                22


<210> 1746
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1746
gagacagguu caugcugcua                                                   20


<210> 1747
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1747
uagcagcaug aaccugucuc                                                   20


<210> 1748
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1748
auagcagcau aagccugucu c                                                 21


<210> 1749
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1749
gagacaggcu uaugcugcua u                                                 21


<210> 1750
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1750
uguguggauc cuggaggagg ca                                                22


<210> 1751
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1751
ugccuccucc aggauccaca ca                                                22


<210> 1752
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1752
agacaucaag aucaguccca aa                                                22


<210> 1753
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1753
uuugggacug aucuugaugu cu                                                22


<210> 1754
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1754
uuugggacug aucuugaugu cu                                                22


<210> 1755
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1755
agacaucaag aucaguccca aa                                                22


<210> 1756
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1756
aaggaaccag aaaaugagaa gu                                                22


<210> 1757
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1757
acuucucauu uucugguucc uu                                                22


<210> 1758
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1758
ucuggccuug acuugacucu uu                                                22


<210> 1759
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1759
aaagagucaa gucaaggcca ga                                                22


<210> 1760
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1760
ucaaggccag aggucccaca gca                                               23


<210> 1761
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1761
ugcuguggga ccucuggccu uga                                               23


<210> 1762
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1762
acuccaguuu uaguucucuu g                                                 21


<210> 1763
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1763
caagagaacu aaaacuggag u                                                 21


<210> 1764
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1764
aagagaacug aaaguggagc cu                                                22


<210> 1765
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1765
aggcuccacu uucaguucuc uu                                                22


<210> 1766
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1766
uaaggggugu auggcagaug ca                                                22


<210> 1767
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1767
ugcaucugcc auacaccccu ua                                                22


<210> 1768
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1768
uuucagauaa caguauuaca u                                                 21


<210> 1769
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1769
auguaauacu guuaucugaa a                                                 21


<210> 1770
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1770
aagcaauacu guuaccugaa au                                                22


<210> 1771
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1771
auuucaggua acaguauugc uu                                                22


<210> 1772
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1772
uacuaacugc agauucaagu ga                                                22


<210> 1773
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1773
ucacuugaau cugcaguuag ua                                                22


<210> 1774
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1774
auugccuaac augugccaga a                                                 21


<210> 1775
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1775
uucuggcaca uguuaggcaa u                                                 21


<210> 1776
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1776
ucugguaugu aguagguaau aa                                                22


<210> 1777
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1777
uuauuaccua cuacauacca ga                                                22


<210> 1778
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1778
aguugccuuu uuguucccau gc                                                22


<210> 1779
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1779
gcaugggaac aaaaaggcaa cu                                                22


<210> 1780
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1780
auaggcacca aaaagcaaca a                                                 21


<210> 1781
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1781
uuguugcuuu uuggugccua u                                                 21


<210> 1782
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1782
ccugcaacuu ugccugauca ga                                                22


<210> 1783
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1783
ucugaucagg caaaguugca gg                                                22


<210> 1784
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1784
ugaucaggca aaauugcaga cu                                                22


<210> 1785
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1785
agucugcaau uuugccugau ca                                                22


<210> 1786
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1786
uuguggcugg ucaugaggcu aa                                                22


<210> 1787
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1787
uuagccucau gaccagccac aa                                                22


<210> 1788
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1788
uuagucucau gaucagacac a                                                 21


<210> 1789
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1789
ugugucugau caugagacua a                                                 21


<210> 1790
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1790
aaagauagac aauuggcuaa au                                                22


<210> 1791
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1791
auuuagccaa uugucuaucu uu                                                22


<210> 1792
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1792
uuagccaauu guccaucuuu ag                                                22


<210> 1793
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1793
cuaaagaugg acaauuggcu aa                                                22


<210> 1794
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1794
ucugugagac caaagaacua cu                                                22


<210> 1795
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1795
aguaguucuu uggucucaca ga                                                22


<210> 1796
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1796
uuguucuuug gucuuucagc ca                                                22


<210> 1797
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1797
uggcugaaag accaaagaac aa                                                22


<210> 1798
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1798
cgggcugucc ggaggggucg gcu                                               23


<210> 1799
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1799
agccgacccc uccggacagc ccg                                               23


<210> 1800
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1800
ucuguauucu ccuuugccug cag                                               23


<210> 1801
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1801
cugcaggcaa aggagaauac aga                                               23


<210> 1802
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1802
uacauggaug gaaaccuuca agc                                               23


<210> 1803
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1803
gcuugaaggu uuccauccau gua                                               23


<210> 1804
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1804
uauggagguu cuagaccaug uu                                                22


<210> 1805
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1805
aacauggucu agaaccucca ua                                                22


<210> 1806
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1806
gggaccaucc ugccugcugu gg                                                22


<210> 1807
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1807
ccacagcagg caggaugguc cc                                                22


<210> 1808
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1808
ucagcaggca ggcuggugca gc                                                22


<210> 1809
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1809
gcugcaccag ccugccugcu ga                                                22


<210> 1810
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1810
ucaccugacc ucccaugccu gu                                                22


<210> 1811
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1811
acaggcaugg gaggucaggu ga                                                22


<210> 1812
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1812
caggcacggg agcucaggug ag                                                22


<210> 1813
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1813
cucaccugag cucccgugcc ug                                                22


<210> 1814
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1814
ugaguguugu cuacgagggc a                                                 21


<210> 1815
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1815
ugcccucgua gacaacacuc a                                                 21


<210> 1816
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1816
acugacagga gagcauuuug a                                                 21


<210> 1817
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1817
ucaaaaugcu cuccugucag u                                                 21


<210> 1818
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1818
ugaccuggga cucggacagc ug                                                22


<210> 1819
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1819
cagcuguccg agucccaggu ca                                                22


<210> 1820
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1820
ucucaggagu aaagacagag uu                                                22


<210> 1821
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1821
aacucugucu uuacuccuga ga                                                22


<210> 1822
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1822
aacucugucu ucacucauga gu                                                22


<210> 1823
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1823
acucaugagu gaagacagag uu                                                22


<210> 1824
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1824
uggggcggag cuuccggagg cc                                                22


<210> 1825
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1825
ggccuccgga agcuccgccc ca                                                22


<210> 1826
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1826
caaucagcaa guauacugcc cu                                                22


<210> 1827
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1827
agggcaguau acuugcugau ug                                                22


<210> 1828
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1828
uggcaguguc uuagcugguu gu                                                22


<210> 1829
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1829
acaaccagcu aagacacugc ca                                                22


<210> 1830
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1830
ccaauauugg cugugcugcu cc                                                22


<210> 1831
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1831
ggagcagcac agccaauauu gg                                                22


<210> 1832
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1832
uagcagcaca gaaauauugg c                                                 21


<210> 1833
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1833
gccaauauuu cugugcugcu a                                                 21


<210> 1834
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1834
uaauuuuaug uauaagcuag u                                                 21


<210> 1835
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1835
acuagcuuau acauaaaauu a                                                 21


<210> 1836
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1836
gagcuuauuc auaaaagugc ag                                                22


<210> 1837
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1837
cugcacuuuu augaauaagc uc                                                22


<210> 1838
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1838
aagacgggag gaaagaaggg ag                                                22


<210> 1839
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1839
cucccuucuu uccucccguc uu                                                22


<210> 1840
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1840
cagugguuuu acccuauggu ag                                                22


<210> 1841
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1841
cuaccauagg guaaaaccac ug                                                22


<210> 1842
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1842
auucuaauuu cuccacgucu uu                                                22


<210> 1843
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1843
aaagacgugg agaaauuaga au                                                22


<210> 1844
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1844
aaccagcacc ccaacuuugg ac                                                22


<210> 1845
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1845
guccaaaguu ggggugcugg uu                                                22


<210> 1846
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1846
aaagacauag gauagaguca ccuc                                              24


<210> 1847
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1847
gaggugacuc uauccuaugu cuuu                                              24


<210> 1848
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1848
uaacugguug aacaacugaa cc                                                22


<210> 1849
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1849
gguucaguug uucaaccagu ua                                                22


<210> 1850
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1850
cgugccaccc uuuuccccag                                                   20


<210> 1851
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1851
cuggggaaaa ggguggcacg                                                   20


<210> 1852
<211> 17
<212> RNA
<213> Homo sapiens

<400> 1852
guggggccag gcggugg                                                      17


<210> 1853
<211> 17
<212> RNA
<213> Homo sapiens

<400> 1853
ccaccgccug gccccac                                                      17


<210> 1854
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1854
aaaagcuggg uugagagggc aa                                                22


<210> 1855
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1855
uugcccucuc aacccagcuu uu                                                22


<210> 1856
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1856
gguccagagg ggagauaggu uc                                                22


<210> 1857
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1857
gaaccuaucu ccccucugga cc                                                22


<210> 1858
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1858
uagccuucag aucuuggugu uuu                                               23


<210> 1859
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1859
aaaacaccaa gaucugaagg cua                                               23


<210> 1860
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1860
ccacuuggau cugaaggcug ccc                                               23


<210> 1861
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1861
gggcagccuu cagauccaag ugg                                               23


<210> 1862
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1862
ugugcgcagg gagaccucuc cc                                                22


<210> 1863
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1863
gggagagguc ucccugcgca ca                                                22


<210> 1864
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1864
ugucuacuac uggagacacu gg                                                22


<210> 1865
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1865
ccagugucuc caguaguaga ca                                                22


<210> 1866
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1866
aaggcagggc ccccgcuccc c                                                 21


<210> 1867
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1867
ggggagcggg ggcccugccu u                                                 21


<210> 1868
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1868
cugacuguug ccguccucca g                                                 21


<210> 1869
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1869
cuggaggacg gcaacaguca g                                                 21


<210> 1870
<211> 25
<212> RNA
<213> Homo sapiens

<400> 1870
aaaaaccaca auuacuuuug cacca                                             25


<210> 1871
<211> 25
<212> RNA
<213> Homo sapiens

<400> 1871
uggugcaaaa guaauugugg uuuuu                                             25


<210> 1872
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1872
caaaaaccgc aauuacuuuu gca                                               23


<210> 1873
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1873
ugcaaaagua auugcgguuu uug                                               23


<210> 1874
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1874
augugccuga gggaguaaga ca                                                22


<210> 1875
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1875
ugucuuacuc ccucaggcac au                                                22


<210> 1876
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1876
ucuuacuccc ucaggcacug                                                   20


<210> 1877
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1877
cagugccuga gggaguaaga                                                   20


<210> 1878
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1878
agacacauuu ggagagggac cc                                                22


<210> 1879
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1879
gggucccucu ccaaaugugu cu                                                22


<210> 1880
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1880
gguucccucu ccaaaugugu cu                                                22


<210> 1881
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1881
agacacauuu ggagagggaa cc                                                22


<210> 1882
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1882
aaaauuucuu ucacuacuua g                                                 21


<210> 1883
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1883
cuaaguagug aaagaaauuu u                                                 21


<210> 1884
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1884
uuagugaagg cuauuuuaau u                                                 21


<210> 1885
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1885
aauuaaaaua gccuucacua a                                                 21


<210> 1886
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1886
acuguaaacg cuuucugaug                                                   20


<210> 1887
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1887
caucagaaag cguuuacagu                                                   20


<210> 1888
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1888
gcaugugaug aagcaaauca gu                                                22


<210> 1889
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1889
acugauuugc uucaucacau gc                                                22


<210> 1890
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1890
caaagugaug aguaauacug gcug                                              24


<210> 1891
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1891
cagccaguau uacucaucac uuug                                              24


<210> 1892
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1892
gaaucggaaa ggaggcgccg                                                   20


<210> 1893
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1893
cggcgccucc uuuccgauuc                                                   20


<210> 1894
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1894
uugugaagaa agaaauucuu a                                                 21


<210> 1895
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1895
uaagaauuuc uuucuucaca a                                                 21


<210> 1896
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1896
aggaggcauc uugagaaaug ga                                                22


<210> 1897
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1897
uccauuucuc aagaugccuc cu                                                22


<210> 1898
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1898
acaaaaaaaa aagcccaacc cuuc                                              24


<210> 1899
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1899
gaaggguugg gcuuuuuuuu uugu                                              24


<210> 1900
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1900
uguuguacuu uuuuuuuugu uc                                                22


<210> 1901
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1901
gaacaaaaaa aaaaguacaa ca                                                22


<210> 1902
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1902
ucucucggcu ccucgcggcu c                                                 21


<210> 1903
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1903
gagccgcgag gagccgagag a                                                 21


<210> 1904
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1904
cgagggcauu ucaugaugca ggc                                               23


<210> 1905
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1905
gccugcauca ugaaaugccc ucg                                               23


<210> 1906
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1906
augaagugca cucaugauau gu                                                22


<210> 1907
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1907
acauaucaug agugcacuuc au                                                22


<210> 1908
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1908
ugucuacauu aaugaaaaga gc                                                22


<210> 1909
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1909
gcucuuuuca uuaauguaga ca                                                22


<210> 1910
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1910
ucacccugca ucccgcaccc ag                                                22


<210> 1911
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1911
cugggugcgg gaugcagggu ga                                                22


<210> 1912
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1912
gugggcuggg cugggcuggg cc                                                22


<210> 1913
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1913
ggcccagccc agcccagccc ac                                                22


<210> 1914
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1914
cgcgggucgg ggucugcagg                                                   20


<210> 1915
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1915
ccugcagacc ccgacccgcg                                                   20


<210> 1916
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1916
ucaccugagc ucccgugccu g                                                 21


<210> 1917
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1917
caggcacggg agcucaggug a                                                 21


<210> 1918
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1918
aggcauggga ggucagguga                                                   20


<210> 1919
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1919
ucaccugacc ucccaugccu                                                   20


<210> 1920
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1920
caucagcacc cuauguccuu ucu                                               23


<210> 1921
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1921
agaaaggaca uagggugcug aug                                               23


<210> 1922
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1922
aaagacauag uugcaagaug gg                                                22


<210> 1923
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1923
cccaucuugc aacuaugucu uu                                                22


<210> 1924
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1924
uuugugaccu gguccacuaa cc                                                22


<210> 1925
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1925
gguuagugga ccaggucaca aa                                                22


<210> 1926
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1926
gaugguugac cagagagcac ac                                                22


<210> 1927
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1927
gugugcucuc uggucaacca uc                                                22


<210> 1928
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1928
aaaagcuggg uugagagggu                                                   20


<210> 1929
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1929
acccucucaa cccagcuuuu                                                   20


<210> 1930
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1930
cacaagguau ugguauuacc u                                                 21


<210> 1931
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1931
agguaauacc aauaccuugu g                                                 21


<210> 1932
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1932
uaguaccagu accuuguguu ca                                                22


<210> 1933
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1933
ugaacacaag guacugguac ua                                                22


<210> 1934
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1934
aguauucugu accagggaag gu                                                22


<210> 1935
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1935
accuucccug guacagaaua cu                                                22


<210> 1936
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1936
uggcagugua uuguuagcug gu                                                22


<210> 1937
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1937
accagcuaac aauacacugc ca                                                22


<210> 1938
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1938
uauacaaggg caagcucucu gu                                                22


<210> 1939
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1939
acagagagcu ugcccuugua ua                                                22


<210> 1940
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1940
agcgagguug cccuuuguau au                                                22


<210> 1941
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1941
auauacaaag ggcaaccucg cu                                                22


<210> 1942
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1942
caaucacuaa cuccacugcc au                                                22


<210> 1943
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1943
auggcagugg aguuagugau ug                                                22


<210> 1944
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1944
uaggcagugu cauuagcuga uug                                               23


<210> 1945
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1945
caaucagcua augacacugc cua                                               23


<210> 1946
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1946
cagccacaac uacccugcca cu                                                22


<210> 1947
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1947
aguggcaggg uaguuguggc ug                                                22


<210> 1948
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1948
aggcagugua uuguuagcug gc                                                22


<210> 1949
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1949
gccagcuaac aauacacugc cu                                                22


<210> 1950
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1950
aaucacuaac cacacggcca gg                                                22


<210> 1951
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1951
ccuggccgug ugguuaguga uu                                                22


<210> 1952
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1952
aggcagugua guuagcugau ugc                                               23


<210> 1953
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1953
gcaaucagcu aacuacacug ccu                                               23


<210> 1954
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1954
guccgcucgg cgguggccca                                                   20


<210> 1955
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1955
ugggccaccg ccgagcggac                                                   20


<210> 1956
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1956
gaacgccugu ucuugccagg ugg                                               23


<210> 1957
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1957
ccaccuggca agaacaggcg uuc                                               23


<210> 1958
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1958
aagugugcag ggcacuggu                                                    19


<210> 1959
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1959
accagugccc ugcacacuu                                                    19


<210> 1960
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1960
aggggugcua ucugugauug a                                                 21


<210> 1961
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1961
ucaaucacag auagcacccc u                                                 21


<210> 1962
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1962
cuuucaguca gauguuugcu gc                                                22


<210> 1963
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1963
gcagcaaaca ucugacugaa ag                                                22


<210> 1964
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1964
uguaaacauc cccgacugga ag                                                22


<210> 1965
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1965
cuuccagucg gggauguuua ca                                                22


<210> 1966
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1966
uguaaacauc cucgacugga ag                                                22


<210> 1967
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1967
cuuccagucg aggauguuua ca                                                22


<210> 1968
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1968
agaaguaauu gcgguuuugc ca                                                22


<210> 1969
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1969
uggcaaaacc gcaauuacuu cu                                                22


<210> 1970
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1970
caaaacuggc aauuacuuuu gc                                                22


<210> 1971
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1971
gcaaaaguaa uugccaguuu ug                                                22


<210> 1972
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1972
aaaaguaauu gcgaguuuua cc                                                22


<210> 1973
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1973
gguaaaacuc gcaauuacuu uu                                                22


<210> 1974
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1974
caagaaccuc aguugcuuuu gu                                                22


<210> 1975
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1975
acaaaagcaa cugagguucu ug                                                22


<210> 1976
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1976
caaaaaucuc aauuacuuuu gc                                                22


<210> 1977
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1977
gcaaaaguaa uugagauuuu ug                                                22


<210> 1978
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1978
caaaaaccac aguuucuuuu gc                                                22


<210> 1979
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1979
gcaaaagaaa cugugguuuu ug                                                22


<210> 1980
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1980
aaaaguaauu gugguuuuug cc                                                22


<210> 1981
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1981
ggcaaaaacc acaauuacuu uu                                                22


<210> 1982
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1982
ugacaacuau ggaugagcuc u                                                 21


<210> 1983
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1983
agagcucauc cauaguuguc a                                                 21


<210> 1984
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1984
aacaggugac ugguuagaca a                                                 21


<210> 1985
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1985
uugucuaacc agucaccugu u                                                 21


<210> 1986
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1986
aaaacgguga gauuuuguuu u                                                 21


<210> 1987
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1987
aaaacaaaau cucaccguuu u                                                 21


<210> 1988
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1988
gcuaguccug acucagccag u                                                 21


<210> 1989
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1989
acuggcugag ucaggacuag c                                                 21


<210> 1990
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1990
aggguaagcu gaaccucuga u                                                 21


<210> 1991
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1991
aucagagguu cagcuuaccc u                                                 21


<210> 1992
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1992
auauuaccau uagcucaucu uu                                                22


<210> 1993
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1993
aaagaugagc uaaugguaau au                                                22


<210> 1994
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1994
gaugagcuca uuguaauaug ag                                                22


<210> 1995
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1995
cucauauuac aaugagcuca uc                                                22


<210> 1996
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1996
agguugacau acguuuccc                                                    19


<210> 1997
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1997
gggaaacgua ugucaaccu                                                    19


<210> 1998
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1998
auguauaaau guauacacac                                                   20


<210> 1999
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1999
guguguauac auuuauacau                                                   20


<210> 2000
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2000
cugaagugau guguaacuga ucag                                              24


<210> 2001
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2001
cugaucaguu acacaucacu ucag                                              24


<210> 2002
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2002
aagaugugga aaaauuggaa uc                                                22


<210> 2003
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2003
gauuccaauu uuuccacauc uu                                                22


<210> 2004
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2004
uagauaaaau auugguaccu g                                                 21


<210> 2005
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2005
cagguaccaa uauuuuaucu a                                                 21


<210> 2006
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2006
cuucuugugc ucuaggauug u                                                 21


<210> 2007
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2007
acaauccuag agcacaagaa g                                                 21


<210> 2008
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2008
uaugcauugu auuuuuaggu cc                                                22


<210> 2009
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2009
ggaccuaaaa auacaaugca ua                                                22


<210> 2010
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2010
uuuccauagg ugaugaguca c                                                 21


<210> 2011
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2011
gugacucauc accuauggaa a                                                 21


<210> 2012
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2012
uuggccacaa uggguuagaa c                                                 21


<210> 2013
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2013
guucuaaccc auuguggcca a                                                 21


<210> 2014
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2014
ugugucacuc gaugaccacu gu                                                22


<210> 2015
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2015
acagugguca ucgagugaca ca                                                22


<210> 2016
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2016
acuuacagac aagagccuug cuc                                               23


<210> 2017
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2017
gagcaaggcu cuugucugua agu                                               23


<210> 2018
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2018
aggcugcgga auucaggac                                                    19


<210> 2019
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2019
guccugaauu ccgcagccu                                                    19


<210> 2020
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2020
uaaaucccau ggugccuucu ccu                                               23


<210> 2021
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2021
aggagaaggc accaugggau uua                                               23


<210> 2022
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2022
aaacuacuga aaaucaaaga u                                                 21


<210> 2023
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2023
aucuuugauu uucaguaguu u                                                 21


<210> 2024
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2024
guucaaaucc agaucuauaa c                                                 21


<210> 2025
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2025
guuauagauc uggauuugaa c                                                 21


<210> 2026
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2026
ccgguuccag ucccuggag                                                    19


<210> 2027
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2027
cuccagggac uggaaccgg                                                    19


<210> 2028
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2028
aggguguuuc ucucaucucu                                                   20


<210> 2029
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2029
agagaugaga gaaacacccu                                                   20


<210> 2030
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2030
gaccuggaca uguuugugcc cagu                                              24


<210> 2031
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2031
acugggcaca aacaugucca gguc                                              24


<210> 2032
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2032
auggagauag auauagaaau                                                   20


<210> 2033
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2033
auuucuauau cuaucuccau                                                   20


<210> 2034
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2034
agcugucuga aaaugucuu                                                    19


<210> 2035
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2035
aagacauuuu cagacagcu                                                    19


<210> 2036
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2036
agaccuggcc cagaccucag c                                                 21


<210> 2037
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2037
gcugaggucu gggccagguc u                                                 21


<210> 2038
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2038
acuugggcac ugaaacaaug ucc                                               23


<210> 2039
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2039
ggacauuguu ucagugccca agu                                               23


<210> 2040
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2040
acugggggcu uucgggcucu gcgu                                              24


<210> 2041
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2041
acgcagagcc cgaaagcccc cagu                                              24


<210> 2042
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2042
aucgcugcgg uugcgagcgc ugu                                               23


<210> 2043
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2043
acagcgcucg caaccgcagc gau                                               23


<210> 2044
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2044
gucccucucc aaaugugucu ug                                                22


<210> 2045
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2045
caagacacau uuggagaggg ac                                                22


<210> 2046
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2046
acuuguaugc uagcucaggu ag                                                22


<210> 2047
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2047
cuaccugagc uagcauacaa gu                                                22


<210> 2048
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2048
uuuaggauaa gcuugacuuu ug                                                22


<210> 2049
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2049
caaaagucaa gcuuauccua aa                                                22


<210> 2050
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2050
guguugaaac aaucucuacu g                                                 21


<210> 2051
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2051
caguagagau uguuucaaca c                                                 21


<210> 2052
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2052
uaugucugcu gaccaucacc uu                                                22


<210> 2053
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2053
aaggugaugg ucagcagaca ua                                                22


<210> 2054
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2054
ggggcugggg ccggggccga gc                                                22


<210> 2055
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2055
gcucggcccc ggccccagcc cc                                                22


<210> 2056
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2056
ugagguagua gguuguaugg uu                                                22


<210> 2057
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2057
aaccauacaa ccuacuaccu ca                                                22


<210> 2058
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2058
gugucuuuug cucugcaguc a                                                 21


<210> 2059
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2059
ugacugcaga gcaaaagaca c                                                 21


<210> 2060
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2060
ccccgggaac gucgagacug gagc                                              24


<210> 2061
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2061
gcuccagucu cgacguuccc gggg                                              24


<210> 2062
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2062
acccgucccg uucguccccg ga                                                22


<210> 2063
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2063
uccggggacg aacgggacgg gu                                                22


<210> 2064
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2064
augggugaau uuguagaagg au                                                22


<210> 2065
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2065
auccuucuac aaauucaccc au                                                22


<210> 2066
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2066
cuggacugag ccgugcuacu gg                                                22


<210> 2067
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2067
ccaguagcac ggcucagucc ag                                                22


<210> 2068
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2068
cuggacugag ccaugcuacu gg                                                22


<210> 2069
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2069
ccaguagcau ggcucagucc ag                                                22


<210> 2070
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2070
uacguagaua uauauguauu uu                                                22


<210> 2071
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2071
aaaauacaua uauaucuacg ua                                                22


<210> 2072
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2072
aaauauauau auauauguac guau                                              24


<210> 2073
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2073
gcucuuuuca uuaauguaga ca                                                22


<210> 2074
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2074
ugcuggauca gugguucgag uc                                                22


<210> 2075
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2075
gacucgaacc acugauccag ca                                                22


<210> 2076
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2076
uggauuuuug gaucaggga                                                    19


<210> 2077
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2077
ucccugaucc aaaaaucca                                                    19


<210> 2078
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2078
uuauaaagca augagacuga uu                                                22


<210> 2079
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2079
aaucagucuc auugcuuuau aa                                                22


<210> 2080
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2080
uagugcaaua uugcuuauag ggu                                               23


<210> 2081
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2081
acccuauaag caauauugca cua                                               23


<210> 2082
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2082
acccuaucaa uauugucucu gc                                                22


<210> 2083
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2083
gcagagacaa uauugauagg gu                                                22


<210> 2084
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2084
uaagugcuuc caugcuu                                                      17


<210> 2085
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2085
aagcauggaa gcacuua                                                      17


<210> 2086
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2086
ucggccugac cacccacccc ac                                                22


<210> 2087
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2087
gugggguggg uggucaggcc ga                                                22


<210> 2088
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2088
gggggggggg ggggggggcc g                                                 21


<210> 2089
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2089
cggccccccc cccccccccc c                                                 21


<210> 2090
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2090
cuauacgacc ugcugccuuu cu                                                22


<210> 2091
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2091
agaaaggcag caggucguau ag                                                22


<210> 2092
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2092
agagguagua gguugcauag uu                                                22


<210> 2093
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2093
aacuaugcaa ccuacuaccu cu                                                22


<210> 2094
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2094
ccgcacugug gguacuugcu gc                                                22


<210> 2095
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2095
gcagcaagua cccacagugc gg                                                22


<210> 2096
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2096
uaaagugcug acagugcaga u                                                 21


<210> 2097
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2097
aucugcacug ucagcacuuu a                                                 21


<210> 2098
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2098
aacuggauca auuauaggag ug                                                22


<210> 2099
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2099
cacuccuaua auugauccag uu                                                22


<210> 2100
<211> 26
<212> RNA
<213> Homo sapiens

<400> 2100
aaguaguugg uuuguaugag augguu                                            26


<210> 2101
<211> 26
<212> RNA
<213> Homo sapiens

<400> 2101
aaccaucuca uacaaaccaa cuacuu                                            26


<210> 2102
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2102
aagugaucua aaggccuaca u                                                 21


<210> 2103
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2103
auguaggccu uuagaucacu u                                                 21


<210> 2104
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2104
ucagaugauc uaaaggccua ua                                                22


<210> 2105
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2105
uauaggccuu uagaucaucu ga                                                22


<210> 2106
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2106
uaggccuuua gaucacuuaa a                                                 21


<210> 2107
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2107
uuuaagugau cuaaaggccu a                                                 21


<210> 2108
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2108
acucuagcug ccaaaggcgc u                                                 21


<210> 2109
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2109
agcgccuuug gcagcuagag u                                                 21


<210> 2110
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2110
agaaggaaau ugaauucauu ua                                                22


<210> 2111
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2111
uaaaugaauu caauuuccuu cu                                                22


<210> 2112
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2112
agagaagaag aucagccugc a                                                 21


<210> 2113
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2113
ugcaggcuga ucuucuucuc u                                                 21


<210> 2114
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2114
agccuggaag cuggagccug cagu                                              24


<210> 2115
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2115
acugcaggcu ccagcuucca ggcu                                              24


<210> 2116
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2116
aggaugagca aagaaaguag auu                                               23


<210> 2117
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2117
aaucuacuuu cuuugcucau ccu                                               23


<210> 2118
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2118
aaccacuuuc uuugcucauc ca                                                22


<210> 2119
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2119
uggaugagca aagaaagugg uu                                                22


<210> 2120
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2120
cggaugagca aagaaagugg uu                                                22


<210> 2121
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2121
aaccacuuuc uuugcucauc cg                                                22


<210> 2122
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2122
aggcauugac uucucacuag cu                                                22


<210> 2123
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2123
agcuagugag aagucaaugc cu                                                22


<210> 2124
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2124
agugaaugau ggguucugac c                                                 21


<210> 2125
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2125
ggucagaacc caucauucac u                                                 21


<210> 2126
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2126
aguuaggauu aggucgugga a                                                 21


<210> 2127
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2127
uuccacgacc uaauccuaac u                                                 21


<210> 2128
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2128
auggauaagg cuuuggcuu                                                    19


<210> 2129
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2129
aagccaaagc cuuauccau                                                    19


<210> 2130
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2130
augguacccu ggcauacuga gu                                                22


<210> 2131
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2131
acucaguaug ccaggguacc au                                                22


<210> 2132
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2132
caagucuuau uugagcaccu guu                                               23


<210> 2133
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2133
aacaggugcu caaauaagac uug                                               23


<210> 2134
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2134
caggaugugg ucaaguguug uu                                                22


<210> 2135
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2135
aacaacacuu gaccacaucc ug                                                22


<210> 2136
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2136
ccucagggcu guagaacagg gcu                                               23


<210> 2137
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2137
agcccuguuc uacagcccug agg                                               23


<210> 2138
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2138
ccuguugaag uguaaucccc a                                                 21


<210> 2139
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2139
uggggauuac acuucaacag g                                                 21


<210> 2140
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2140
cgggcguggu gguggggg                                                     18


<210> 2141
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2141
cccccaccac cacgcccg                                                     18


<210> 2142
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2142
cgggcguggu ggugggggug                                                   20


<210> 2143
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2143
cacccccacc accacgcccg                                                   20


<210> 2144
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2144
cuggagauau ggaagagcug ugu                                               23


<210> 2145
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2145
acacagcucu uccauaucuc cag                                               23


<210> 2146
<211> 26
<212> RNA
<213> Homo sapiens

<400> 2146
gaugaugaug gcagcaaauu cugaaa                                            26


<210> 2147
<211> 26
<212> RNA
<213> Homo sapiens

<400> 2147
uuucagaauu ugcugccauc aucauc                                            26


<210> 2148
<211> 25
<212> RNA
<213> Homo sapiens

<400> 2148
gggcgacaaa gcaagacucu uucuu                                             25


<210> 2149
<211> 25
<212> RNA
<213> Homo sapiens

<400> 2149
aagaaagagu cuugcuuugu cgccc                                             25


<210> 2150
<211> 25
<212> RNA
<213> Homo sapiens

<400> 2150
gaacccauga gguugaggcu gcagu                                             25


<210> 2151
<211> 25
<212> RNA
<213> Homo sapiens

<400> 2151
acugcagccu caaccucaug gguuc                                             25


<210> 2152
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2152
gugggggaga ggcuguc                                                      17


<210> 2153
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2153
gacagccucu cccccac                                                      17


<210> 2154
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2154
uaaagagccc uguggagaca                                                   20


<210> 2155
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2155
ugucuccaca gggcucuuua                                                   20


<210> 2156
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2156
uaguacugug cauaucaucu au                                                22


<210> 2157
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2157
auagaugaua ugcacaguac ua                                                22


<210> 2158
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2158
ucguuugccu uuuucugcuu                                                   20


<210> 2159
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2159
aagcagaaaa aggcaaacga                                                   20


<210> 2160
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2160
uggacugccc ugaucuggag a                                                 21


<210> 2161
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2161
ucuccagauc agggcagucc a                                                 21


<210> 2162
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2162
uggguggucu ggagauuugu gc                                                22


<210> 2163
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2163
gcacaaaucu ccagaccacc ca                                                22


<210> 2164
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2164
ugugagguug gcauuguugu cu                                                22


<210> 2165
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2165
agacaacaau gccaaccuca ca                                                22


<210> 2166
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2166
uucaaguaau ucaggug                                                      17


<210> 2167
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2167
caccugaauu acuugaa                                                      17


<210> 2168
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2168
uucuggaauu cugugugagg ga                                                22


<210> 2169
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2169
ucccucacac agaauuccag aa                                                22


<210> 2170
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2170
uuuucaacuc uaaugggaga ga                                                22


<210> 2171
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2171
ucucucccau uagaguugaa aa                                                22


<210> 2172
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2172
acguuggcuc ugguggug                                                     18


<210> 2173
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2173
caccaccaga gccaacgu                                                     18


<210> 2174
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2174
ccaccucccc ugcaaacguc ca                                                22


<210> 2175
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2175
uggacguuug caggggaggu gg                                                22


<210> 2176
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2176
acucggcgug gcgucggucg ug                                                22


<210> 2177
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2177
cacgaccgac gccacgccga gu                                                22


<210> 2178
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2178
ucgaccggac cucgaccggc u                                                 21


<210> 2179
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2179
agccggucga gguccggucg a                                                 21


<210> 2180
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2180
ugagaacuga auuccauagg cu                                                22


<210> 2181
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2181
agccuaugga auucaguucu ca                                                22


<210> 2182
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2182
aaucauacac gguugaccua uu                                                22


<210> 2183
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2183
aauaggucaa ccguguauga uu                                                22


<210> 2184
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2184
uagguuaucc guguugccuu cg                                                22


<210> 2185
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2185
cgaaggcaac acggauaacc ua                                                22


<210> 2186
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2186
ccaguccugu gccugccgcc u                                                 21


<210> 2187
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2187
aggcggcagg cacaggacug g                                                 21


<210> 2188
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2188
ucugcccccu ccgcugcugc ca                                                22


<210> 2189
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2189
uggcagcagc ggagggggca ga                                                22


<210> 2190
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2190
ggaggggucc cgcacuggga gg                                                22


<210> 2191
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2191
ccucccagug cgggaccccu cc                                                22


<210> 2192
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2192
cccugugccc ggcccacuuc ug                                                22


<210> 2193
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2193
cagaaguggg ccgggcacag gg                                                22


<210> 2194
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2194
ccccagggcg acgcggcggg                                                   20


<210> 2195
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2195
cccgccgcgu cgcccugggg                                                   20


<210> 2196
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2196
accuugccuu gcugcccggg cc                                                22


<210> 2197
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2197
ggcccgggca gcaaggcaag gu                                                22


<210> 2198
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2198
auuugugcuu ggcucuguca c                                                 21


<210> 2199
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2199
gugacagagc caagcacaaa u                                                 21


<210> 2200
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2200
auuguccuug cuguuuggag au                                                22


<210> 2201
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2201
aucuccaaac agcaaggaca au                                                22


<210> 2202
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2202
auccccagau acaauggaca a                                                 21


<210> 2203
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2203
uuguccauug uaucugggga u                                                 21


<210> 2204
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2204
cagugcaaua guauugucaa agc                                               23


<210> 2205
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2205
gcuuugacaa uacuauugca cug                                               23


<210> 2206
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2206
gcucugacuu uauugcacua cu                                                22


<210> 2207
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2207
aguagugcaa uaaagucaga gc                                                22


<210> 2208
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2208
uaagugcuuc cauguuuuag uag                                               23


<210> 2209
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2209
cuacuaaaac auggaagcac uua                                               23


<210> 2210
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2210
acuuuaacau ggaagugcuu uc                                                22


<210> 2211
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2211
gaaagcacuu ccauguuaaa gu                                                22


<210> 2212
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2212
uaagugcuuc cauguuucag ugg                                               23


<210> 2213
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2213
ccacugaaac auggaagcac uua                                               23


<210> 2214
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2214
uuuaacaugg ggguaccugc ug                                                22


<210> 2215
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2215
cagcagguac ccccauguua aa                                                22


<210> 2216
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2216
uaagugcuuc cauguuugag ugu                                               23


<210> 2217
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2217
acacucaaac auggaagcac uua                                               23


<210> 2218
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2218
acuuuaacau ggaggcacuu gc                                                22


<210> 2219
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2219
gcaagugccu ccauguuaaa gu                                                22


<210> 2220
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2220
aauugcacuu uagcaauggu ga                                                22


<210> 2221
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2221
ucaccauugc uaaagugcaa uu                                                22


<210> 2222
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2222
acuguugcua auaugcaacu cu                                                22


<210> 2223
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2223
agaguugcau auuagcaaca gu                                                22


<210> 2224
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2224
agcucggucu gaggccccuc agu                                               23


<210> 2225
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2225
acugaggggc cucagaccga gcu                                               23


<210> 2226
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2226
aaaaacugag acuacuuuug ca                                                22


<210> 2227
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2227
ugcaaaagua gucucaguuu uu                                                22


<210> 2228
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2228
aaaaacugua auuacuuuu                                                    19


<210> 2229
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2229
aaaaguaauu acaguuuuu                                                    19


<210> 2230
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2230
aaaacuguaa uuacuuuugu ac                                                22


<210> 2231
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2231
guacaaaagu aauuacaguu uu                                                22


<210> 2232
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2232
ugcaaaagua auugcaguuu uug                                               23


<210> 2233
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2233
caaaaacugc aauuacuuuu gca                                               23


<210> 2234
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2234
caaaaaccgc aauuacuuuu gca                                               23


<210> 2235
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2235
ugcaaaagua auugcgguuu uug                                               23


<210> 2236
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2236
aaaaguaauc gcgguuuuug uc                                                22


<210> 2237
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2237
gacaaaaacc gcgauuacuu uu                                                22


<210> 2238
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2238
aaaaguacuu gcggauuuug cu                                                22


<210> 2239
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2239
agcaaaaucc gcaaguacuu uu                                                22


<210> 2240
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2240
aaaaguauuu gcggguuuug uc                                                22


<210> 2241
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2241
gacaaaaccc gcaaauacuu uu                                                22


<210> 2242
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2242
caaagguauu ugugguuuuu g                                                 21


<210> 2243
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2243
caaaaaccac aaauaccuuu g                                                 21


<210> 2244
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2244
ccaaaacugc aguuacuuuu gc                                                22


<210> 2245
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2245
gcaaaaguaa cugcaguuuu gg                                                22


<210> 2246
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2246
aaaaguaauu gcgguuuuug cc                                                22


<210> 2247
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2247
ggcaaaaacc gcaauuacuu uu                                                22


<210> 2248
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2248
uagcaaaaac ugcaguuacu uu                                                22


<210> 2249
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2249
aaaguaacug caguuuuugc ua                                                22


<210> 2250
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2250
ggagguuggg aagggcagag                                                   20


<210> 2251
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2251
cucugcccuu cccaaccucc                                                   20


<210> 2252
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2252
ugaggcgggg gggcgagc                                                     18


<210> 2253
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2253
gcucgccccc ccgccuca                                                     18


<210> 2254
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2254
agagaugaag cgggggggcg                                                   20


<210> 2255
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2255
cgcccccccg cuucaucucu                                                   20


<210> 2256
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2256
ggaggccggg guggggcggg gcgg                                              24


<210> 2257
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2257
ccgccccgcc ccaccccggc cucc                                              24


<210> 2258
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2258
ggggagcgag gggcggggc                                                    19


<210> 2259
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2259
gccccgcccc ucgcucccc                                                    19


<210> 2260
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2260
uauucauuua uccccagccu aca                                               23


<210> 2261
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2261
uguaggcugg ggauaaauga aua                                               23


<210> 2262
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2262
acuggcuagg gaaaaugauu ggau                                              24


<210> 2263
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2263
auccaaucau uuucccuagc cagu                                              24


<210> 2264
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2264
uucauuugcc ucccagccua ca                                                22


<210> 2265
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2265
uguaggcugg gaggcaaaug aa                                                22


<210> 2266
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2266
ugggcuaagg gagaugauug ggua                                              24


<210> 2267
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2267
uacccaauca ucucccuuag ccca                                              24


<210> 2268
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2268
acuccagccc cacagccuca gc                                                22


<210> 2269
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2269
gcugaggcug uggggcugga gu                                                22


<210> 2270
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2270
aggaggaauu ggugcugguc uu                                                22


<210> 2271
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2271
aagaccagca ccaauuccuc cu                                                22


<210> 2272
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2272
aggcagcggg guguagugga ua                                                22


<210> 2273
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2273
uauccacuac accccgcugc cu                                                22


<210> 2274
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2274
uccauuacac uacccugccu cu                                                22


<210> 2275
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2275
agaggcaggg uaguguaaug ga                                                22


<210> 2276
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2276
acugcugagc uagcacuucc cg                                                22


<210> 2277
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2277
cgggaagugc uagcucagca gu                                                22


<210> 2278
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2278
caaagugcug uucgugcagg uag                                               23


<210> 2279
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2279
cuaccugcac gaacagcacu uug                                               23


<210> 2280
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2280
cacccggcug ugugcacaug ugc                                               23


<210> 2281
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2281
gcacaugugc acacagccgg gug                                               23


<210> 2282
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2282
agcuucuuua cagugcugcc uug                                               23


<210> 2283
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2283
caaggcagca cuguaaagaa gcu                                               23


<210> 2284
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2284
agcagcauug uacagggcua uga                                               23


<210> 2285
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2285
ucauagcccu guacaaugcu gcu                                               23


<210> 2286
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2286
ccugagaaaa gggccaa                                                      17


<210> 2287
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2287
uuggcccuuu ucucagg                                                      17


<210> 2288
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2288
ggccacugag ucagcacca                                                    19


<210> 2289
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2289
uggugcugac ucaguggcc                                                    19


<210> 2290
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2290
agggcauguc cagggggu                                                     18


<210> 2291
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2291
acccccugga caugcccu                                                     18


<210> 2292
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2292
gccuggagcu acuccaccau cuc                                               23


<210> 2293
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2293
gagauggugg aguagcucca ggc                                               23


<210> 2294
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2294
caguguucag agaugga                                                      17


<210> 2295
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2295
uccaucucug aacacug                                                      17


<210> 2296
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2296
aucugaccug augaaggu                                                     18


<210> 2297
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2297
accuucauca ggucagau                                                     18


<210> 2298
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2298
ccagaggugg ggacugag                                                     18


<210> 2299
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2299
cucagucccc accucugg                                                     18


<210> 2300
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2300
ccccgccacc gccuugg                                                      17


<210> 2301
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2301
ccaaggcggu ggcgggg                                                      17


<210> 2302
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2302
caguuggguc uaggggucag ga                                                22


<210> 2303
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2303
uccugacccc uagacccaac ug                                                22


<210> 2304
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2304
cuuggggcau ggaguccca                                                    19


<210> 2305
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2305
ugggacucca ugccccaag                                                    19


<210> 2306
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2306
aggaaacagg gaccca                                                       16


<210> 2307
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2307
ugggucccug uuuccu                                                       16


<210> 2308
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2308
gacauucaga cuaccug                                                      17


<210> 2309
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2309
cagguagucu gaauguc                                                      17


<210> 2310
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2310
auucuaagug ccuuggcc                                                     18


<210> 2311
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2311
ggccaaggca cuuagaau                                                     18


<210> 2312
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2312
acucagucau ggucauu                                                      17


<210> 2313
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2313
aaugaccaug acugagu                                                      17


<210> 2314
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2314
cugugggcuc agcucuggg                                                    19


<210> 2315
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2315
cccagagcug agcccacag                                                    19


<210> 2316
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2316
cuaggaggcc uuggcc                                                       16


<210> 2317
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2317
ggccaaggcc uccuag                                                       16


<210> 2318
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2318
uccagcucgg uggcac                                                       16


<210> 2319
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2319
gugccaccga gcugga                                                       16


<210> 2320
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2320
ggcuccuccu cucaggaugu g                                                 21


<210> 2321
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2321
cacauccuga gaggaggagc c                                                 21


<210> 2322
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2322
gcaggcacag acagcccugg c                                                 21


<210> 2323
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2323
gccagggcug ucugugccug c                                                 21


<210> 2324
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2324
ucagggaguc aggggagggc                                                   20


<210> 2325
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2325
gcccuccccu gacucccuga                                                   20


<210> 2326
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2326
gggggaagaa aaggugggg                                                    19


<210> 2327
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2327
ccccaccuuu ucuuccccc                                                    19


<210> 2328
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2328
cauucaacua gugauugu                                                     18


<210> 2329
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2329
acaaucacua guugaaug                                                     18


<210> 2330
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2330
cagcaguccc ucccccug                                                     18


<210> 2331
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2331
cagggggagg gacugcug                                                     18


<210> 2332
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2332
ccaauuacca cuucuuu                                                      17


<210> 2333
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2333
aaagaagugg uaauugg                                                      17


<210> 2334
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2334
cucagugacu caugugc                                                      17


<210> 2335
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2335
gcacaugagu cacugag                                                      17


<210> 2336
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2336
gcaguucuga gcacaguaca c                                                 21


<210> 2337
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2337
guguacugug cucagaacug c                                                 21


<210> 2338
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2338
cuaggggguu ugcccuug                                                     18


<210> 2339
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2339
caagggcaaa cccccuag                                                     18


<210> 2340
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2340
cucuccuccc ggcuuc                                                       16


<210> 2341
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2341
gaagccggga ggagag                                                       16


<210> 2342
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2342
gaguguaguu cugagcagag c                                                 21


<210> 2343
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2343
gcucugcuca gaacuacacu c                                                 21


<210> 2344
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2344
gggucccggg gagggggg                                                     18


<210> 2345
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2345
ccccccuccc cgggaccc                                                     18


<210> 2346
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2346
uaaaauuugc auccagga                                                     18


<210> 2347
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2347
uccuggaugc aaauuuua                                                     18


<210> 2348
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2348
uggggcucag cgaguuu                                                      17


<210> 2349
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2349
aaacucgcug agcccca                                                      17


<210> 2350
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2350
gggcucacau caccccau                                                     18


<210> 2351
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2351
auggggugau gugagccc                                                     18


<210> 2352
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2352
gcggcgaguc cgacucau                                                     18


<210> 2353
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2353
augagucgga cucgccgc                                                     18


<210> 2354
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2354
accccacucc ugguacc                                                      17


<210> 2355
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2355
gguaccagga guggggu                                                      17


<210> 2356
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2356
ucucccuuga gggcacuuu                                                    19


<210> 2357
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2357
aaagugcccu caagggaga                                                    19


<210> 2358
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2358
uugucugcug aguuucc                                                      17


<210> 2359
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2359
ggaaacucag cagacaa                                                      17


<210> 2360
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2360
gcauugugca gggcuauca                                                    19


<210> 2361
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2361
ugauagcccu gcacaaugc                                                    19


<210> 2362
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2362
ugcccuccuu ucuucccuc                                                    19


<210> 2363
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2363
gagggaagaa aggagggca                                                    19


<210> 2364
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2364
uucagcagga acagcu                                                       16


<210> 2365
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2365
agcuguuccu gcugaa                                                       16


<210> 2366
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2366
ccccugggcc ggccuugg                                                     18


<210> 2367
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2367
ccaaggccgg cccagggg                                                     18


<210> 2368
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2368
cagccugaca ggaacag                                                      17


<210> 2369
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2369
cuguuccugu caggcug                                                      17


<210> 2370
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2370
gggagucuac agcaggg                                                      17


<210> 2371
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2371
cccugcugua gacuccc                                                      17


<210> 2372
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2372
cagugcaaug uuuuccuu                                                     18


<210> 2373
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2373
aaggaaaaca uugcacug                                                     18


<210> 2374
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2374
augugggcuc aggcuca                                                      17


<210> 2375
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2375
ugagccugag cccacau                                                      17


<210> 2376
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2376
ugccuuccug ucugug                                                       16


<210> 2377
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2377
cacagacagg aaggca                                                       16


<210> 2378
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2378
cugggacagg aggaggaggc ag                                                22


<210> 2379
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2379
cugccuccuc cuccuguccc ag                                                22


<210> 2380
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2380
gcuggugaca ugagaggc                                                     18


<210> 2381
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2381
gccucucaug ucaccagc                                                     18


<210> 2382
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2382
ugggagcugg acuacuuc                                                     18


<210> 2383
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2383
gaaguagucc agcuccca                                                     18


<210> 2384
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2384
ucccacuacu ucacuuguga                                                   20


<210> 2385
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2385
ucacaaguga aguaguggga                                                   20


<210> 2386
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2386
ccaguguggc ucagcgag                                                     18


<210> 2387
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2387
cucgcugagc cacacugg                                                     18


<210> 2388
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2388
uucugagcug aggacag                                                      17


<210> 2389
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2389
cuguccucag cucagaa                                                      17


<210> 2390
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2390
ccggcauguc cagggca                                                      17


<210> 2391
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2391
ugcccuggac augccgg                                                      17


<210> 2392
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2392
ccuagacacc uccaguuc                                                     18


<210> 2393
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2393
gaacuggagg ugucuagg                                                     18


<210> 2394
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2394
uggagagaaa ggcagua                                                      17


<210> 2395
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2395
uacugccuuu cucucca                                                      17


<210> 2396
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2396
aauguuuuuu ccuguuucc                                                    19


<210> 2397
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2397
ggaaacagga aaaaacauu                                                    19


<210> 2398
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2398
ucccuggagu uucuucuu                                                     18


<210> 2399
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2399
aagaagaaac uccaggga                                                     18


<210> 2400
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2400
cuggagucua ggauucca                                                     18


<210> 2401
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2401
uggaauccua gacuccag                                                     18


<210> 2402
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2402
gcagcauuca uguccc                                                       16


<210> 2403
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2403
gggacaugaa ugcugc                                                       16


<210> 2404
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2404
gaaagagagc ugagugug                                                     18


<210> 2405
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2405
cacacucagc ucucuuuc                                                     18


<210> 2406
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2406
ggccuuguuc cugucccca                                                    19


<210> 2407
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2407
uggggacagg aacaaggcc                                                    19


<210> 2408
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2408
agcccccugg ccccaaaccc                                                   20


<210> 2409
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2409
ggguuugggg ccagggggcu                                                   20


<210> 2410
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2410
cucugggaaa ugggacag                                                     18


<210> 2411
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2411
cugucccauu ucccagag                                                     18


<210> 2412
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2412
ccgcuuucug agcuggac                                                     18


<210> 2413
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2413
guccagcuca gaaagcgg                                                     18


<210> 2414
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2414
ggugaggcua gcuggug                                                      17


<210> 2415
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2415
caccagcuag ccucacc                                                      17


<210> 2416
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2416
acauugccag ggaguuu                                                      17


<210> 2417
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2417
aaacucccug gcaaugu                                                      17


<210> 2418
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2418
cacugugggu acaugcu                                                      17


<210> 2419
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2419
agcauguacc cacagug                                                      17


<210> 2420
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2420
ucccugagca aagccac                                                      17


<210> 2421
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2421
guggcuuugc ucaggga                                                      17


<210> 2422
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2422
gggauucugu agcuuccu                                                     18


<210> 2423
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2423
aggaagcuac agaauccc                                                     18


<210> 2424
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2424
uuagcggugg accgcccugc g                                                 21


<210> 2425
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2425
cgcagggcgg uccaccgcua a                                                 21


<210> 2426
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2426
cugugggcuc agcgcguggg g                                                 21


<210> 2427
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2427
ccccacgcgc ugagcccaca g                                                 21


<210> 2428
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2428
cagccccaca gccucaga                                                     18


<210> 2429
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2429
ucugaggcug uggggcug                                                     18


<210> 2430
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2430
cccugagacc cuaaccuuaa                                                   20


<210> 2431
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2431
uuaagguuag ggucucaggg                                                   20


<210> 2432
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2432
uugcacuugu cucaguga                                                     18


<210> 2433
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2433
ucacugagac aagugcaa                                                     18


<210> 2434
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2434
uguuccucug ucucccagac                                                   20


<210> 2435
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2435
gucugggaga cagaggaaca                                                   20


<210> 2436
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2436
ggcuugcaug ggggacugg                                                    19


<210> 2437
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2437
ccaguccccc augcaagcc                                                    19


<210> 2438
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2438
ccaguuuucc caggauu                                                      17


<210> 2439
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2439
aauccuggga aaacugg                                                      17


<210> 2440
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2440
ccugagaccc uaguuccac                                                    19


<210> 2441
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2441
guggaacuag ggucucagg                                                    19


<210> 2442
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2442
ccucagauca gagccuugc                                                    19


<210> 2443
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2443
gcaaggcucu gaucugagg                                                    19


<210> 2444
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2444
cauugcacuu gucucggucu ga                                                22


<210> 2445
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2445
ucagaccgag acaagugcaa ug                                                22


<210> 2446
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2446
aggcggagac uugggcaauu g                                                 21


<210> 2447
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2447
caauugccca agucuccgcc u                                                 21


<210> 2448
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2448
ccuauucuug guuacuugca cg                                                22


<210> 2449
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2449
cgugcaagua accaagaaua gg                                                22


<210> 2450
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2450
aauggauuuu uggagcagg                                                    19


<210> 2451
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2451
ccugcuccaa aaauccauu                                                    19


<210> 2452
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2452
ugcggggcua gggcuaacag ca                                                22


<210> 2453
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2453
ugcuguuagc ccuagccccg ca                                                22


<210> 2454
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2454
aaaaguaauu gcggauuuug cc                                                22


<210> 2455
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2455
ggcaaaaucc gcaauuacuu uu                                                22


<210> 2456
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2456
caaaaguaau uguggauuuu gu                                                22


<210> 2457
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2457
acaaaaucca caauuacuuu ug                                                22


<210> 2458
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2458
uaagugcuuc cauguuuugg uga                                               23


<210> 2459
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2459
ucaccaaaac auggaagcac uua                                               23


<210> 2460
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2460
acuuaaacgu ggauguacuu gcu                                               23


<210> 2461
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2461
agcaaguaca uccacguuua agu                                               23


<210> 2462
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2462
cuauacaauc uacugucuuu c                                                 21


<210> 2463
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2463
gaaagacagu agauuguaua g                                                 21


<210> 2464
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2464
ugagguagua gguuguauag uu                                                22


<210> 2465
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2465
aacuauacaa ccuacuaccu ca                                                22


<210> 2466
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2466
cuguacagcc uccuagcuuu cc                                                22


<210> 2467
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2467
ggaaagcuag gaggcuguac ag                                                22


<210> 2468
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2468
caccaggcau uguggucucc                                                   20


<210> 2469
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2469
ggagaccaca augccuggug                                                   20


<210> 2470
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2470
ugaguaccgc caugucuguu ggg                                               23


<210> 2471
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2471
cccaacagac auggcgguac uca                                               23


<210> 2472
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2472
uacccagagc augcagugug aa                                                22


<210> 2473
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2473
uucacacugc augcucuggg ua                                                22


<210> 2474
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2474
aagugcuguc auagcugagg uc                                                22


<210> 2475
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2475
gaccucagcu augacagcac uu                                                22


<210> 2476
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2476
cacucagccu ugagggcacu uuc                                               23


<210> 2477
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2477
gaaagugccc ucaaggcuga gug                                               23


<210> 2478
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2478
ucgacagcac gacacugccu uc                                                22


<210> 2479
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2479
gaaggcagug ucgugcuguc ga                                                22


<210> 2480
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2480
uagguaguuu ccuguuguug gg                                                22


<210> 2481
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2481
cccaacaaca ggaaacuacc ua                                                22


<210> 2482
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2482
uacaguacug ugauaacuga a                                                 21


<210> 2483
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2483
uucaguuauc acaguacugu a                                                 21


<210> 2484
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2484
caguuaucac agugcugaug cu                                                22


<210> 2485
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2485
agcaucagca cugugauaac ug                                                22


<210> 2486
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2486
ugugcaaauc uaugcaaaac uga                                               23


<210> 2487
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2487
ucaguuuugc auagauuugc aca                                               23


<210> 2488
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2488
aguuuugcau aguugcacua ca                                                22


<210> 2489
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2489
uguagugcaa cuaugcaaaa cu                                                22


<210> 2490
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2490
aguuuugcag guuugcaucc agc                                               23


<210> 2491
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2491
gcuggaugca aaccugcaaa acu                                               23


<210> 2492
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2492
aguuuugcag guuugcauuu ca                                                22


<210> 2493
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2493
ugaaaugcaa accugcaaaa cu                                                22


<210> 2494
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2494
ugugcaaauc caugcaaaac uga                                               23


<210> 2495
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2495
ucaguuuugc auggauuugc aca                                               23


<210> 2496
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2496
uacugcauca ggaacugauu gga                                               23


<210> 2497
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2497
uccaaucagu uccugaugca gua                                               23


<210> 2498
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2498
augguuccgu caagcaccau gg                                                22


<210> 2499
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2499
ccauggugcu ugacggaacc au                                                22


<210> 2500
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2500
agcuacaucu ggcuacuggg u                                                 21


<210> 2501
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2501
acccaguagc cagauguagc u                                                 21


<210> 2502
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2502
cucaguagcc aguguagauc cu                                                22


<210> 2503
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2503
aggaucuaca cuggcuacug ag                                                22


<210> 2504
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2504
uuaucagaau cuccaggggu ac                                                22


<210> 2505
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2505
guaccccugg agauucugau aa                                                22


<210> 2506
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2506
aucaacagac auuaauuggg cgc                                               23


<210> 2507
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2507
gcgcccaauu aaugucuguu gau                                               23


<210> 2508
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2508
caaaacguga ggcgcugcua u                                                 21


<210> 2509
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2509
auagcagcgc cucacguuuu g                                                 21


<210> 2510
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2510
cagcagcaau ucauguuuug aa                                                22


<210> 2511
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2511
uucaaaacau gaauugcugc ug                                                22


<210> 2512
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2512
uucacaggga ggugucau                                                     18


<210> 2513
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2513
augacaccuc ccugugaa                                                     18


<210> 2514
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2514
gcggagagag aauggggagc                                                   20


<210> 2515
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2515
gcuccccauu cucucuccgc                                                   20


<210> 2516
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2516
ccugcgaguc uccggcggug g                                                 21


<210> 2517
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2517
ccaccgccgg agacucgcag g                                                 21


<210> 2518
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2518
gggcuagggc cugcugcccc c                                                 21


<210> 2519
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2519
gggggcagca ggcccuagcc c                                                 21


<210> 2520
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2520
uucugcugcc ggccaaggc                                                    19


<210> 2521
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2521
gccuuggccg gcagcagaa                                                    19


<210> 2522
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2522
uccucaucac acugcaccuu ag                                                22


<210> 2523
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2523
cuaaggugca gugugaugag ga                                                22


<210> 2524
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2524
gguagugagu uaucagcuac                                                   20


<210> 2525
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2525
guagcugaua acucacuacc                                                   20


<210> 2526
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2526
gauauucaga ggcuaggugg                                                   20


<210> 2527
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2527
ccaccuagcc ucugaauauc                                                   20


<210> 2528
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2528
acggcccagg cggcauuggu g                                                 21


<210> 2529
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2529
caccaaugcc gccugggccg u                                                 21


<210> 2530
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2530
agcaugacag aggagaggug g                                                 21


<210> 2531
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2531
ccaccucucc ucugucaugc u                                                 21


<210> 2532
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2532
gggaagagcu guacggccuu c                                                 21


<210> 2533
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2533
gaaggccgua cagcucuucc c                                                 21


<210> 2534
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2534
ccgccugagc uagcugugg                                                    19


<210> 2535
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2535
ccacagcuag cucaggcgg                                                    19


<210> 2536
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2536
uuggaagcuu ggaccaacua gcug                                              24


<210> 2537
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2537
cagcuaguug guccaagcuu ccaa                                              24


<210> 2538
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2538
ucuagugcgg gcguucccg                                                    19


<210> 2539
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2539
cgggaacgcc cgcacuaga                                                    19


<210> 2540
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2540
aggagcagug ccggccaagg cgcc                                              24


<210> 2541
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2541
ggcgccuugg ccggcacugc uccu                                              24


<210> 2542
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2542
gaauacgucu gguugaucc                                                    19


<210> 2543
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2543
ggaucaacca gacguauuc                                                    19


<210> 2544
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2544
cuuauaucag aggcuguggg                                                   20


<210> 2545
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2545
cccacagccu cugauauaag                                                   20


<210> 2546
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2546
uuccgccagu cgguggccgg                                                   20


<210> 2547
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2547
ccggccaccg acuggcggaa                                                   20


<210> 2548
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2548
aaggggcugg gggagcaca                                                    19


<210> 2549
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2549
ugugcucccc cagccccuu                                                    19


<210> 2550
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2550
agguugggau cgguugcaau gcu                                               23


<210> 2551
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2551
agcauugcaa ccgaucccaa ccu                                               23


<210> 2552
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2552
ggguggggau uuguugcauu ac                                                22


<210> 2553
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2553
guaaugcaac aaauccccac cc                                                22


<210> 2554
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2554
uauugcacuu gucccggccu gu                                                22


<210> 2555
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2555
acaggccggg acaagugcaa ua                                                22


<210> 2556
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2556
uauugcacuc gucccggccu cc                                                22


<210> 2557
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2557
ggaggccggg acgagugcaa ua                                                22


<210> 2558
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2558
agggacggga cgcggugcag ug                                                22


<210> 2559
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2559
cacugcaccg cgucccgucc cu                                                22


<210> 2560
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2560
aucacauugc cagggauuuc c                                                 21


<210> 2561
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2561
ggaaaucccu ggcaauguga u                                                 21


<210> 2562
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2562
gggguuccug gggaugggau uu                                                22


<210> 2563
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2563
aaaucccauc cccaggaacc cc                                                22


<210> 2564
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2564
acugcaguga aggcacuugu ag                                                22


<210> 2565
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2565
cuacaagugc cuucacugca gu                                                22


<210> 2566
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2566
agcuacauug ucugcugggu uuc                                               23


<210> 2567
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2567
gaaacccagc agacaaugua gcu                                               23


<210> 2568
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2568
accuggcaua caauguagau uu                                                22


<210> 2569
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2569
aaaucuacau uguaugccag gu                                                22


<210> 2570
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2570
ucguaccgug aguaauaaug cg                                                22


<210> 2571
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2571
cgcauuauua cucacgguac ga                                                22


<210> 2572
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2572
cauuauuacu uuugguacgc g                                                 21


<210> 2573
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2573
cgcguaccaa aaguaauaau g                                                 21


<210> 2574
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2574
uacuccagag ggcgucacuc aug                                               23


<210> 2575
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2575
caugagugac gcccucugga gua                                               23


<210> 2576
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2576
ucccacguug uggcccagca g                                                 21


<210> 2577
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2577
cugcugggcc acaacguggg a                                                 21


<210> 2578
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2578
ccucaccacc ccuucugccu gca                                               23


<210> 2579
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2579
ugcaggcaga agggguggug agg                                               23


<210> 2580
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2580
cugcaggcag aaguggggcu gaca                                              24


<210> 2581
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2581
ugucagcccc acuucugccu gcag                                              24


<210> 2582
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2582
ccaaaccagu cgugccugug g                                                 21


<210> 2583
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2583
ccacaggcac gacugguuug g                                                 21


<210> 2584
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2584
cucaaaccgg cugugccugu gg                                                22


<210> 2585
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2585
ccacaggcac agccgguuug ag                                                22


<210> 2586
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2586
acaggcacga cugguuuggc a                                                 21


<210> 2587
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2587
ugccaaacca gucgugccug u                                                 21


<210> 2588
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2588
uccgaacucu ccauuccucu gc                                                22


<210> 2589
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2589
gcagaggaau ggagaguucg ga                                                22


<210> 2590
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2590
ugggaauggg gguaagggcc                                                   20


<210> 2591
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2591
ggcccuuacc cccauuccca                                                   20


<210> 2592
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2592
aggcgaugug gggauguaga ga                                                22


<210> 2593
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2593
ucucuacauc cccacaucgc cu                                                22


<210> 2594
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2594
uaguggucag agggcuuaug a                                                 21


<210> 2595
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2595
ucauaagccc ucugaccacu a                                                 21


<210> 2596
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2596
ucugacauca gugauucucc ug                                                22


<210> 2597
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2597
caggagaauc acugauguca ga                                                22


<210> 2598
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2598
cgcgccugca ggaacuggua ga                                                22


<210> 2599
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2599
ucuaccaguu ccugcaggcg cg                                                22


<210> 2600
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2600
ugggcagggg cuuauuguag gag                                               23


<210> 2601
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2601
cuccuacaau aagccccugc cca                                               23


<210> 2602
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2602
ugcagggguc gggugggcca gg                                                22


<210> 2603
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2603
ccuggcccac ccgaccccug ca                                                22


<210> 2604
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2604
aggcgcaccc gaccacaugc                                                   20


<210> 2605
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2605
gcaugugguc gggugcgccu                                                   20


<210> 2606
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2606
auaguccgag uaacgucggg gc                                                22


<210> 2607
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2607
gccccgacgu uacucggacu au                                                22


<210> 2608
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2608
cugggcccgc ggcgggcgug ggg                                               23


<210> 2609
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2609
ccccacgccc gccgcgggcc cag                                               23


<210> 2610
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2610
uacuuggaaa ggcaucaguu g                                                 21


<210> 2611
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2611
caacugaugc cuuuccaagu a                                                 21


<210> 2612
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2612
ugcaacgaac cugagccacu ga                                                22


<210> 2613
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2613
ucaguggcuc agguucguug ca                                                22


<210> 2614
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2614
ugcaacuuac cugagucauu ga                                                22


<210> 2615
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2615
ucaaugacuc agguaaguug ca                                                22


<210> 2616
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2616
cacugugucc uuucugcgua g                                                 21


<210> 2617
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2617
cuacgcagaa aggacacagu g                                                 21


<210> 2618
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2618
cacuggcucc uuucugggua ga                                                22


<210> 2619
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2619
ucuacccaga aaggagccag ug                                                22


<210> 2620
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2620
cacuguuucc uuucugagug ga                                                22


<210> 2621
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2621
uccacucaga aaggaaacag ug                                                22


<210> 2622
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2622
uauucagaaa ggugccaguc a                                                 21


<210> 2623
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2623
ugacuggcac cuuucugaau a                                                 21


<210> 2624
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2624
auuccuagaa auuguucaua                                                   20


<210> 2625
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2625
uaugaacaau uucuaggaau                                                   20


<210> 2626
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2626
uaauacuguc ugguaaaacc gu                                                22


<210> 2627
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2627
acgguuuuac cagacaguau ua                                                22


<210> 2628
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2628
ugaaacauac acgggaaacc uc                                                22


<210> 2629
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2629
gagguuuccc guguauguuu ca                                                22


<210> 2630
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2630
cuauacaacc uacugccuuc cc                                                22


<210> 2631
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2631
gggaaggcag uagguuguau ag                                                22


<210> 2632
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2632
ugagguagua gguugugugg uu                                                22


<210> 2633
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2633
aaccacacaa ccuacuaccu ca                                                22


<210> 2634
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2634
uaacacuguc ugguaacgau gu                                                22


<210> 2635
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2635
acaucguuac cagacagugu ua                                                22


<210> 2636
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2636
caucuuaccg gacagugcug ga                                                22


<210> 2637
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2637
uccagcacug uccgguaaga ug                                                22


<210> 2638
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2638
uaauacugcc ugguaaugau ga                                                22


<210> 2639
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2639
ucaucauuac caggcaguau ua                                                22


<210> 2640
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2640
caucuuacug ggcagcauug ga                                                22


<210> 2641
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2641
uccaaugcug cccaguaaga ug                                                22


<210> 2642
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2642
uaauacugcc ggguaaugau gga                                               23


<210> 2643
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2643
uccaucauua cccggcagua uua                                               23


<210> 2644
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2644
cgucuuaccc agcaguguuu gg                                                22


<210> 2645
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2645
ccaaacacug cuggguaaga cg                                                22


<210> 2646
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2646
uccagcauca gugauuuugu ug                                                22


<210> 2647
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2647
caacaaaauc acugaugcug ga                                                22


<210> 2648
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2648
uacaguauag augauguacu                                                   20


<210> 2649
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2649
aguacaucau cuauacugua                                                   20


<210> 2650
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2650
ggauaucauc auauacugua ag                                                22


<210> 2651
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2651
cuuacaguau augaugauau cc                                                22


<210> 2652
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2652
cggggcagcu caguacagga u                                                 21


<210> 2653
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2653
auccuguacu gagcugcccc g                                                 21


<210> 2654
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2654
uccuucugcu ccguccccca g                                                 21


<210> 2655
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2655
cugggggacg gagcagaagg a                                                 21


<210> 2656
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2656
cgggggcggg gccgaagcgc g                                                 21


<210> 2657
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2657
cgcgcuucgg ccccgccccc g                                                 21


<210> 2658
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2658
uccugcgcgu cccagaugcc c                                                 21


<210> 2659
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2659
gggcaucugg gacgcgcagg a                                                 21


<210> 2660
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2660
caucagaauu cauggaggcu ag                                                22


<210> 2661
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2661
cuagccucca ugaauucuga ug                                                22


<210> 2662
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2662
agcuuccaug acuccugaug ga                                                22


<210> 2663
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2663
uccaucagga gucauggaag cu                                                22


<210> 2664
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2664
ugacagcgcc cugccuggcu c                                                 21


<210> 2665
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2665
gagccaggca gggcgcuguc a                                                 21


<210> 2666
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2666
agcgcgggcu gagcgcugcc aguc                                              24


<210> 2667
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2667
gacuggcagc gcucagcccg cgcu                                              24


<210> 2668
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2668
cugggaggug ugauaucgug gu                                                22


<210> 2669
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2669
accacgauau cacaccuccc ag                                                22


<210> 2670
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2670
ugugauauca ugguuccugg ga                                                22


<210> 2671
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2671
ucccaggaac caugauauca ca                                                22


<210> 2672
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2672
aggugcucca ggcuggcuca ca                                                22


<210> 2673
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2673
ugugagccag ccuggagcac cu                                                22


<210> 2674
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2674
gagcaaugua gguagacugu uu                                                22


<210> 2675
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2675
aaacagucua ccuacauugc uc                                                22


<210> 2676
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2676
uguccucuag ggccugcagu cu                                                22


<210> 2677
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2677
agacugcagg cccuagagga ca                                                22


<210> 2678
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2678
aaaggcauaa aaccaagaca                                                   20


<210> 2679
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2679
ugucuugguu uuaugccuuu                                                   20


<210> 2680
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2680
uaacgcauaa uauggacaug u                                                 21


<210> 2681
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2681
acauguccau auuaugcguu a                                                 21


<210> 2682
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2682
uugaggaaaa gauggucuua uu                                                22


<210> 2683
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2683
aauaagacca ucuuuuccuc aa                                                22


<210> 2684
<211> 26
<212> RNA
<213> Homo sapiens

<400> 2684
aagaggaaga aauggcuggu ucucag                                            26


<210> 2685
<211> 26
<212> RNA
<213> Homo sapiens

<400> 2685
cugagaacca gccauuucuu ccucuu                                            26


<210> 2686
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2686
gcucggacug agcagguggg                                                   20


<210> 2687
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2687
cccaccugcu caguccgagc                                                   20


<210> 2688
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2688
acagggccgc agauggagac u                                                 21


<210> 2689
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2689
agucuccauc ugcggcccug u                                                 21


<210> 2690
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2690
gcagagaaca aaggacucag u                                                 21


<210> 2691
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2691
acugaguccu uuguucucug c                                                 21


<210> 2692
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2692
acugauuauc uuaacucucu ga                                                22


<210> 2693
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2693
ucagagaguu aagauaauca gu                                                22


<210> 2694
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2694
ucucugagua ccauaugccu ugu                                               23


<210> 2695
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2695
acaaggcaua ugguacucag aga                                               23


<210> 2696
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2696
aacuaguaau guuggauuag gg                                                22


<210> 2697
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2697
cccuaaucca acauuacuag uu                                                22


<210> 2698
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2698
auauguauau gugacugcua cu                                                22


<210> 2699
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2699
aguagcaguc acauauacau au                                                22


<210> 2700
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2700
uggccaaaaa gcaggcagag a                                                 21


<210> 2701
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2701
ucucugccug cuuuuuggcc a                                                 21


<210> 2702
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2702
ggaggaaccu uggagcuucg gc                                                22


<210> 2703
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2703
gccgaagcuc caagguuccu cc                                                22


<210> 2704
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2704
gaggcugaug ugaguagacc acu                                               23


<210> 2705
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2705
aguggucuac ucacaucagc cuc                                               23


<210> 2706
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2706
cuguccuaag guuguugagu u                                                 21


<210> 2707
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2707
aacucaacaa ccuuaggaca g                                                 21


<210> 2708
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2708
ucuucaaccu caggacuugc a                                                 21


<210> 2709
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2709
ugcaaguccu gagguugaag a                                                 21


<210> 2710
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2710
ugugauauca ugguuccugg ga                                                22


<210> 2711
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2711
ucccaggaac caugauauca ca                                                22


<210> 2712
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2712
cugggaggug ugauauugug gu                                                22


<210> 2713
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2713
accacaauau cacaccuccc ag                                                22


<210> 2714
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2714
cagguagaua uuugauaggc au                                                22


<210> 2715
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2715
augccuauca aauaucuacc ug                                                22


<210> 2716
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2716
gccuaucaca uaucugccug u                                                 21


<210> 2717
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2717
acaggcagau augugauagg c                                                 21


<210> 2718
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2718
gggcuggggc gcggggaggu                                                   20


<210> 2719
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2719
accuccccgc gccccagccc                                                   20


<210> 2720
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2720
ugcuuccuuu cagagggu                                                     18


<210> 2721
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2721
acccucugaa aggaagca                                                     18


<210> 2722
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2722
ugaguuggcc aucugaguga g                                                 21


<210> 2723
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2723
cucacucaga uggccaacuc a                                                 21


<210> 2724
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2724
aacauucauu guugucggug ggu                                               23


<210> 2725
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2725
acccaccgac aacaaugaau guu                                               23


<210> 2726
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2726
ucacagugaa ccggucucuu u                                                 21


<210> 2727
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2727
aaagagaccg guucacugug a                                                 21


<210> 2728
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2728
caacaaauca cagucugcca ua                                                22


<210> 2729
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2729
uauggcagac ugugauuugu ug                                                22


<210> 2730
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2730
cucacugaac aaugaaugca a                                                 21


<210> 2731
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2731
uugcauucau uguucaguga g                                                 21


<210> 2732
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2732
aacauucauu gcugucggug ggu                                               23


<210> 2733
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2733
acccaccgac agcaaugaau guu                                               23


<210> 2734
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2734
accaucgacc guugauugua cc                                                22


<210> 2735
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2735
gguacaauca acggucgaug gu                                                22


<210> 2736
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2736
aacauucaac gcugucggug agu                                               23


<210> 2737
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2737
acucaccgac agcguugaau guu                                               23


<210> 2738
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2738
accacugacc guugacugua cc                                                22


<210> 2739
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2739
gguacaguca acggucagug gu                                                22


<210> 2740
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2740
cuguugccac uaaccucaac cu                                                22


<210> 2741
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2741
agguugaggu uaguggcaac ag                                                22


<210> 2742
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2742
auaagacgag caaaaagcuu gu                                                22


<210> 2743
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2743
acaagcuuuu ugcucgucuu au                                                22


<210> 2744
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2744
auaagacgaa caaaagguuu gu                                                22


<210> 2745
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2745
acaaaccuuu uguucgucuu au                                                22


<210> 2746
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2746
agggagggac gggggcugug c                                                 21


<210> 2747
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2747
gcacagcccc cgucccuccc u                                                 21


<210> 2748
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2748
ucuggcuccg ugucuucacu ccc                                               23


<210> 2749
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2749
gggagugaag acacggagcc aga                                               23


<210> 2750
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2750
uggaauguaa agaaguaugu au                                                22


<210> 2751
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2751
auacauacuu cuuuacauuc ca                                                22


<210> 2752
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2752
aacaucacag caagucugug cu                                                22


<210> 2753
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2753
agcacagacu ugcugugaug uu                                                22


<210> 2754
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2754
uuaagacuug cagugauguu u                                                 21


<210> 2755
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2755
aaacaucacu gcaagucuua a                                                 21


<210> 2756
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2756
aacaucacug caagucuuaa ca                                                22


<210> 2757
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2757
uguuaagacu ugcagugaug uu                                                22


<210> 2758
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2758
acagacuugc ugugauguuc a                                                 21


<210> 2759
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2759
ugaacaucac agcaagucug u                                                 21


<210> 2760
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2760
aaaccguuac cauuacugag uu                                                22


<210> 2761
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2761
aacucaguaa ugguaacggu uu                                                22


<210> 2762
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2762
uagcaagaga accauuacca uu                                                22


<210> 2763
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2763
aaugguaaug guucucuugc ua                                                22


<210> 2764
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2764
ugaggggcag agagcgagac uuu                                               23


<210> 2765
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2765
aaagucucgc ucucugcccc uca                                               23


<210> 2766
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2766
caagcucgcu ucuauggguc ug                                                22


<210> 2767
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2767
cagacccaua gaagcgagcu ug                                                22


<210> 2768
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2768
aacccguaga uccgaucuug ug                                                22


<210> 2769
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2769
cacaagaucg gaucuacggg uu                                                22


<210> 2770
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2770
caagcucgug ucuguggguc cg                                                22


<210> 2771
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2771
cggacccaca gacacgagcu ug                                                22


<210> 2772
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2772
cacccguaga accgaccuug cg                                                22


<210> 2773
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2773
cgcaaggucg guucuacggg ug                                                22


<210> 2774
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2774
uggagacgcg gcccuguugg agu                                               23


<210> 2775
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2775
acuccaacag ggccgcgucu cca                                               23


<210> 2776
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2776
ucuacagugc acgugucucc agu                                               23


<210> 2777
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2777
acuggagaca cgugcacugu aga                                               23


<210> 2778
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2778
caaauucgua ucuaggggaa ua                                                22


<210> 2779
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2779
uauuccccua gauacgaauu ug                                                22


<210> 2780
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2780
uacccuguag auccgaauuu gug                                               23


<210> 2781
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2781
cacaaauucg gaucuacagg gua                                               23


<210> 2782
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2782
ccugcagcga cuugauggcu ucc                                               23


<210> 2783
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2783
ggaagccauc aagucgcugc agg                                               23


<210> 2784
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2784
ucagugcacu acagaacuuu gu                                                22


<210> 2785
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2785
acaaaguucu guagugcacu ga                                                22


<210> 2786
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2786
aaaguucuga gacacuccga cu                                                22


<210> 2787
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2787
agucggagug ucucagaacu uu                                                22


<210> 2788
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2788
ccuguucucc auuacuuggc uc                                                22


<210> 2789
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2789
gagccaagua auggagaaca gg                                                22


<210> 2790
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2790
uucaaguaau ucaggauagg u                                                 21


<210> 2791
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2791
accuauccug aauuacuuga a                                                 21


<210> 2792
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2792
gcccugaacg aggggucugg ag                                                22


<210> 2793
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2793
cuccagaccc cucguucagg gc                                                22


<210> 2794
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2794
gcugacuccu aguccagggc uc                                                22


<210> 2795
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2795
gagcccugga cuaggaguca gc                                                22


<210> 2796
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2796
aucacacaaa ggcaacuuuu gu                                                22


<210> 2797
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2797
acaaaaguug ccuuugugug au                                                22


<210> 2798
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2798
agagguugcc cuuggugaau uc                                                22


<210> 2799
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2799
gaauucacca agggcaaccu cu                                                22


<210> 2800
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2800
gguagauuuu ccuucuaugg u                                                 21


<210> 2801
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2801
accauagaag gaaaaucuac c                                                 21


<210> 2802
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2802
aucauagagg aaaauccacg u                                                 21


<210> 2803
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2803
acguggauuu uccucuauga u                                                 21


<210> 2804
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2804
guagauucuc cuucuaugag ua                                                22


<210> 2805
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2805
uacucauaga aggagaaucu ac                                                22


<210> 2806
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2806
cugguacagg ccugggggac ag                                                22


<210> 2807
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2807
cuguccccca ggccuguacc ag                                                22


<210> 2808
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2808
ucucccaacc cuuguaccag ug                                                22


<210> 2809
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2809
cacugguaca aggguuggga ga                                                22


<210> 2810
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2810
acggguuagg cucuugggag cu                                                22


<210> 2811
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2811
agcucccaag agccuaaccc gu                                                22


<210> 2812
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2812
ucacaaguca ggcucuuggg ac                                                22


<210> 2813
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2813
gucccaagag ccugacuugu ga                                                22


<210> 2814
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2814
aacccguaga uccgaacuug ug                                                22


<210> 2815
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2815
cacaaguucg gaucuacggg uu                                                22


<210> 2816
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2816
cuguacaggc cacugccuug c                                                 21


<210> 2817
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2817
gcaaggcagu ggccuguaca g                                                 21


<210> 2818
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2818
ugagguagua guuuguacag uu                                                22


<210> 2819
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2819
aacuguacaa acuacuaccu ca                                                22


<210> 2820
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2820
ucccugagac ccuaacuugu ga                                                22


<210> 2821
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2821
ucacaaguua gggucucagg ga                                                22


<210> 2822
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2822
caagcuugua ucuauaggua ug                                                22


<210> 2823
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2823
cauaccuaua gauacaagcu ug                                                22


<210> 2824
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2824
aaagugcugc gacauuugag cgu                                               23


<210> 2825
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2825
acgcucaaau gucgcagcac uuu                                               23


<210> 2826
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2826
uuuagagacg gggucuugcu cu                                                22


<210> 2827
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2827
agagcaagac cccgucucua aa                                                22


<210> 2828
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2828
uggcccugac ugaagaccag cagu                                              24


<210> 2829
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2829
acugcugguc uucagucagg gcca                                              24


<210> 2830
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2830
gcgacccaua cuugguuuca g                                                 21


<210> 2831
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2831
cugaaaccaa guaugggucg c                                                 21


<210> 2832
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2832
gaaaucaagc gugggugaga cc                                                22


<210> 2833
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2833
ggucucaccc acgcuugauu uc                                                22


<210> 2834
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2834
cccugggccu cugcucccca g                                                 21


<210> 2835
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2835
cuggggagca gaggcccagg g                                                 21


<210> 2836
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2836
uggggagcug aggcucuggg ggug                                              24


<210> 2837
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2837
cacccccaga gccucagcuc ccca                                              24


<210> 2838
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2838
ggggagcugu ggaagcagua                                                   20


<210> 2839
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2839
uacugcuucc acagcucccc                                                   20


<210> 2840
<211> 25
<212> RNA
<213> Homo sapiens

<400> 2840
cuagugaggg acagaaccag gauuc                                             25


<210> 2841
<211> 25
<212> RNA
<213> Homo sapiens

<400> 2841
gaauccuggu ucugucccuc acuag                                             25


<210> 2842
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2842
agagucuugu gaugucuugc                                                   20


<210> 2843
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2843
gcaagacauc acaagacucu                                                   20


<210> 2844
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2844
gcagcagaga auaggacuac guc                                               23


<210> 2845
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2845
gacguagucc uauucucugc ugc                                               23


<210> 2846
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2846
ugagcgccuc gacgacagag ccg                                               23


<210> 2847
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2847
cggcucuguc gucgaggcgc uca                                               23


<210> 2848
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2848
ucccuguccu ccaggagcuc acg                                               23


<210> 2849
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2849
cgugagcucc uggaggacag gga                                               23


<210> 2850
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2850
cuauacggcc uccuagcuuu cc                                                22


<210> 2851
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2851
ggaaagcuag gaggccguau ag                                                22


<210> 2852
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2852
ugagguagga gguuguauag uu                                                22


<210> 2853
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2853
aacuauacaa ccuccuaccu ca                                                22


<210> 2854
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2854
cugcgcaagc uacugccuug cu                                                22


<210> 2855
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2855
agcaaggcag uagcuugcgc ag                                                22


<210> 2856
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2856
ugagguagua guuugugcug uu                                                22


<210> 2857
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2857
aacagcacaa acuacuaccu ca                                                22


<210> 2858
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2858
ugcccugugg acucaguucu gg                                                22


<210> 2859
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2859
ccagaacuga guccacaggg ca                                                22


<210> 2860
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2860
ugguucuaga cuugccaacu a                                                 21


<210> 2861
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2861
uaguuggcaa gucuagaacc a                                                 21


<210> 2862
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2862
ugucugcccg caugccugcc ucu                                               23


<210> 2863
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2863
agaggcaggc augcgggcag aca                                               23


<210> 2864
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2864
aaaaguaauu gcggucuuug gu                                                22


<210> 2865
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2865
accaaagacc gcaauuacuu uu                                                22


<210> 2866
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2866
ucgaggagcu cacagucu                                                     18


<210> 2867
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2867
agacugugag cuccucga                                                     18


<210> 2868
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2868
cuauacaauc uauugccuuc cc                                                22


<210> 2869
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2869
gggaaggcaa uagauuguau ag                                                22


<210> 2870
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2870
cuauacaguc uacugucuuu cc                                                22


<210> 2871
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2871
ggaaagacag uagacuguau ag                                                22


<210> 2872
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2872
ugagguagua gauuguauag uu                                                22


<210> 2873
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2873
aacuauacaa ucuacuaccu ca                                                22


<210> 2874
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2874
aaaaguaauu gugguuuugg cc                                                22


<210> 2875
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2875
ggccaaaacc acaauuacuu uu                                                22


<210> 2876
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2876
aaaaguaauu gcgguuuuug cc                                                22


<210> 2877
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2877
ggcaaaaacc gcaauuacuu uu                                                22


<210> 2878
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2878
ccucugaaau ucaguucuuc ag                                                22


<210> 2879
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2879
cugaagaacu gaauuucaga gg                                                22


<210> 2880
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2880
ugagaacuga auuccauggg uu                                                22


<210> 2881
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2881
aacccaugga auucaguucu ca                                                22


<210> 2882
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2882
acagcaggca cagacaggca gu                                                22


<210> 2883
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2883
acugccuguc ugugccugcu gu                                                22


<210> 2884
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2884
ugccugucua cacuugcugu gc                                                22


<210> 2885
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2885
gcacagcaag uguagacagg ca                                                22


<210> 2886
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2886
uagcaccauc ugaaaucggu ua                                                22


<210> 2887
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2887
uaaccgauuu cagauggugc ua                                                22


<210> 2888
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2888
acugauuucu uuugguguuc ag                                                22


<210> 2889
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2889
cugaacacca aaagaaauca gu                                                22


<210> 2890
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2890
gcugguuuca uauggugguu uaga                                              24


<210> 2891
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2891
ucuaaaccac cauaugaaac cagc                                              24


<210> 2892
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2892
cugguuucac augguggcuu ag                                                22


<210> 2893
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2893
cuaagccacc augugaaacc ag                                                22


<210> 2894
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2894
uagcaccauu ugaaaucagu guu                                               23


<210> 2895
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2895
aacacugauu ucaaauggug cua                                               23


<210> 2896
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2896
uagcaccauu ugaaaucggu ua                                                22


<210> 2897
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2897
uaaccgauuu caaauggugc ua                                                22


<210> 2898
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2898
ugaccgauuu cuccuggugu uc                                                22


<210> 2899
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2899
gaacaccagg agaaaucggu ca                                                22


<210> 2900
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2900
ugucacucgg cucggcccac uac                                               23


<210> 2901
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2901
guagugggcc gagccgagug aca                                               23


<210> 2902
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2902
cugccaauuc cauaggucac ag                                                22


<210> 2903
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2903
cugugaccua uggaauuggc ag                                                22


<210> 2904
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2904
cugaccuaug aauugacagc c                                                 21


<210> 2905
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2905
ggcugucaau ucauagguca g                                                 21


<210> 2906
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2906
acugccccag gugcugcugg                                                   20


<210> 2907
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2907
ccagcagcac cuggggcagu                                                   20


<210> 2908
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2908
aacgccauua ucacacuaaa ua                                                22


<210> 2909
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2909
uauuuagugu gauaauggcg uu                                                22


<210> 2910
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2910
cuuucagucg gauguuugca gc                                                22


<210> 2911
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2911
gcugcaaaca uccgacugaa ag                                                22


<210> 2912
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2912
aauugcacgg uauccaucug ua                                                22


<210> 2913
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2913
uacagaugga uaccgugcaa uu                                                22


<210> 2914
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2914
cggguggauc acgaugcaau uu                                                22


<210> 2915
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2915
aaauugcauc gugauccacc cg                                                22


<210> 2916
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2916
cugggaggug gauguuuacu uc                                                22


<210> 2917
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2917
gaaguaaaca uccaccuccc ag                                                22


<210> 2918
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2918
uguaaacauc cuacacucag cu                                                22


<210> 2919
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2919
agcugagugu aggauguuua ca                                                22


<210> 2920
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2920
cugggagagg guuguuuacu cc                                                22


<210> 2921
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2921
ggaguaaaca acccucuccc ag                                                22


<210> 2922
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2922
cugggagaag gcuguuuacu cu                                                22


<210> 2923
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2923
agaguaaaca gccuucuccc ag                                                22


<210> 2924
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2924
uguaaacauc cuacacucuc agc                                               23


<210> 2925
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2925
gcugagagug uaggauguuu aca                                               23


<210> 2926
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2926
uuuuucauua uugcuccuga cc                                                22


<210> 2927
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2927
ggucaggagc aauaaugaaa aa                                                22


<210> 2928
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2928
ucaagagcaa uaacgaaaaa ugu                                               23


<210> 2929
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2929
acauuuuucg uuauugcucu uga                                               23


<210> 2930
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2930
caaagugcuu acagugcagg uag                                               23


<210> 2931
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2931
cuaccugcac uguaagcacu uug                                               23


<210> 2932
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2932
ggauuccugg aaauacuguu cu                                                22


<210> 2933
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2933
agaacaguau uuccaggaau cc                                                22


<210> 2934
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2934
guccaguuuu cccaggaauc ccu                                               23


<210> 2935
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2935
agggauuccu gggaaaacug gac                                               23


<210> 2936
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2936
acugcauuau gagcacuuaa ag                                                22


<210> 2937
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2937
cuuuaagugc ucauaaugca gu                                                22


<210> 2938
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2938
uaaagugcuu auagugcagg uag                                               23


<210> 2939
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2939
cuaccugcac uauaagcacu uua                                               23


<210> 2940
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2940
gaggguuggg uggaggcucu cc                                                22


<210> 2941
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2941
ggagagccuc cacccaaccc uc                                                22


<210> 2942
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2942
cugugcgugu gacagcggcu ga                                                22


<210> 2943
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2943
ucagccgcug ucacacgcac ag                                                22


<210> 2944
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2944
ccaguggggc ugcuguuauc ug                                                22


<210> 2945
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2945
cagauaacag cagccccacu gg                                                22


<210> 2946
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2946
uguaacagca acuccaugug ga                                                22


<210> 2947
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2947
uccacaugga guugcuguua ca                                                22


<210> 2948
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2948
ucacaguggu cucugggauu au                                                22


<210> 2949
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2949
auaaucccag agaccacugu ga                                                22


<210> 2950
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2950
uaaucucagc uggcaacugu ga                                                22


<210> 2951
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2951
ucacaguugc cagcugagau ua                                                22


<210> 2952
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2952
cagugccucg gcagugcagc cc                                                22


<210> 2953
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2953
gggcugcacu gccgaggcac ug                                                22


<210> 2954
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2954
gugcauugcu guugcauugc                                                   20


<210> 2955
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2955
gcaaugcaac agcaaugcac                                                   20


<210> 2956
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2956
acuggacuug gaggcagaa                                                    19


<210> 2957
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2957
uucugccucc aaguccagu                                                    19


<210> 2958
<211> 25
<212> RNA
<213> Homo sapiens

<400> 2958
acuggacuug gagucagaag agugg                                             25


<210> 2959
<211> 25
<212> RNA
<213> Homo sapiens

<400> 2959
ccacucuucu gacuccaagu ccagu                                             25


<210> 2960
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2960
acuggacuug gagucagaaa                                                   20


<210> 2961
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2961
uuucugacuc caaguccagu                                                   20


<210> 2962
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2962
acuggacuug gagucagga                                                    19


<210> 2963
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2963
uccugacucc aaguccagu                                                    19


<210> 2964
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2964
acuggacuug gagccagaag                                                   20


<210> 2965
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2965
cuucuggcuc caaguccagu                                                   20


<210> 2966
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2966
acugggcuug gagucagaag                                                   20


<210> 2967
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2967
cuucugacuc caagcccagu                                                   20


<210> 2968
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2968
acuggacuug gugucagaug g                                                 21


<210> 2969
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2969
ccaucugaca ccaaguccag u                                                 21


<210> 2970
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2970
acuggacuag gagucagaag g                                                 21


<210> 2971
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2971
ccuucugacu ccuaguccag u                                                 21


<210> 2972
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2972
acuggauuug gagccagaa                                                    19


<210> 2973
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2973
uucuggcucc aaauccagu                                                    19


<210> 2974
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2974
aggaauguuc cuucuuugcc                                                   20


<210> 2975
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2975
ggcaaagaag gaacauuccu                                                   20


<210> 2976
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2976
ucagugcaug acagaacuug g                                                 21


<210> 2977
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2977
ccaaguucug ucaugcacug a                                                 21


<210> 2978
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2978
ucacaccugc cucgcccccc                                                   20


<210> 2979
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2979
ggggggcgag gcagguguga                                                   20


<210> 2980
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2980
gugggcgggg gcaggugugu g                                                 21


<210> 2981
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2981
cacacaccug cccccgccca c                                                 21


<210> 2982
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2982
acgcccuucc cccccuucuu ca                                                22


<210> 2983
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2983
ugaagaaggg ggggaagggc gu                                                22


<210> 2984
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2984
uugcauaugu aggauguccc au                                                22


<210> 2985
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2985
augggacauc cuacauaugc aa                                                22


<210> 2986
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2986
guuugcacgg gugggccuug ucu                                               23


<210> 2987
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2987
agacaaggcc cacccgugca aac                                               23


<210> 2988
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2988
gacuauagaa cuuucccccu ca                                                22


<210> 2989
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2989
ugagggggaa aguucuauag uc                                                22


<210> 2990
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2990
agggggaaag uucuauaguc c                                                 21


<210> 2991
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2991
ggacuauaga acuuuccccc u                                                 21


<210> 2992
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2992
cuuuuugcgg ucugggcuug c                                                 21


<210> 2993
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2993
gcaagcccag accgcaaaaa g                                                 21


<210> 2994
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2994
ucuuguguuc ucuagaucag u                                                 21


<210> 2995
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2995
acugaucuag agaacacaag a                                                 21


<210> 2996
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2996
cccaguguuc agacuaccug uuc                                               23


<210> 2997
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2997
gaacagguag ucugaacacu ggg                                               23


<210> 2998
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2998
acaguagucu gcacauuggu ua                                                22


<210> 2999
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2999
uaaccaaugu gcagacuacu gu                                                22


<210> 3000
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3000
acaguagucu gcacauuggu ua                                                22


<210> 3001
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3001
uaaccaaugu gcagacuacu gu                                                22


<210> 3002
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3002
cccaguguuu agacuaucug uuc                                               23


<210> 3003
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3003
gaacagauag ucuaaacacu ggg                                               23


<210> 3004
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3004
uggaguguga caaugguguu ug                                                22


<210> 3005
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3005
caaacaccau ugucacacuc ca                                                22


<210> 3006
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3006
ugcccuaaau gccccuucug gc                                                22


<210> 3007
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3007
gccagaaggg gcauuuaggg ca                                                22


<210> 3008
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3008
uaaggugcau cuagugcagu uag                                               23


<210> 3009
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3009
cuaacugcac uagaugcacc uua                                               23


<210> 3010
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3010
cuccuauaug augccuuucu uc                                                22


<210> 3011
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3011
gaagaaaggc aucauauagg ag                                                22


<210> 3012
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3012
gaacggcuuc auacaggagu u                                                 21


<210> 3013
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3013
aacuccugua ugaagccguu c                                                 21


<210> 3014
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3014
ugugacuggu ugaccagagg gg                                                22


<210> 3015
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3015
ccccucuggu caaccaguca ca                                                22


<210> 3016
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3016
acugcccuaa gugcuccuuc ugg                                               23


<210> 3017
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3017
ccagaaggag cacuuagggc agu                                               23


<210> 3018
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3018
uaaggugcau cuagugcaga uag                                               23


<210> 3019
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3019
cuaucugcac uagaugcacc uua                                               23


<210> 3020
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3020
cagugcaaug augaaagggc au                                                22


<210> 3021
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3021
augcccuuuc aucauugcac ug                                                22


<210> 3022
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3022
acucuuuccc uguugcacua c                                                 21


<210> 3023
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3023
guagugcaac agggaaagag u                                                 21


<210> 3024
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3024
uuuggcaaug guagaacuca cacu                                              24


<210> 3025
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3025
agugugaguu cuaccauugc caaa                                              24


<210> 3026
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3026
agggcccccc cucaauccug u                                                 21


<210> 3027
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3027
acaggauuga gggggggccc u                                                 21


<210> 3028
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3028
cagugcaaug uuaaaagggc au                                                22


<210> 3029
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3029
augcccuuuu aacauugcac ug                                                22


<210> 3030
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3030
uucacauugu gcuacugucu gc                                                22


<210> 3031
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3031
gcagacagua gcacaaugug aa                                                22


<210> 3032
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3032
ucggauccgu cugagcuugg cu                                                22


<210> 3033
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3033
agccaagcuc agacggaucc ga                                                22


<210> 3034
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3034
cugaagcuca gagggcucug au                                                22


<210> 3035
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3035
aucagagccc ucugagcuuc ag                                                22


<210> 3036
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3036
ccucuucccc uugucucucc ag                                                22


<210> 3037
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3037
cuggagagac aaggggaaga gg                                                22


<210> 3038
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3038
ugagugacag gggaaauggg ga                                                22


<210> 3039
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3039
uccccauuuc cccugucacu ca                                                22


<210> 3040
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3040
ucaggacacu ucugaacuug ga                                                22


<210> 3041
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3041
uccaaguuca gaaguguccu ga                                                22


<210> 3042
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3042
caguucagaa guguuccuga gu                                                22


<210> 3043
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3043
acucaggaac acuucugaac ug                                                22


<210> 3044
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3044
uuucccuuuc cauccuggca g                                                 21


<210> 3045
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3045
cugccaggau ggaaagggaa a                                                 21


<210> 3046
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3046
uugccagggc aggaggugga a                                                 21


<210> 3047
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3047
uuccaccucc ugcccuggca a                                                 21


<210> 3048
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3048
agagauuggu agaaaucagg u                                                 21


<210> 3049
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3049
accugauuuc uaccaaucuc u                                                 21


<210> 3050
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3050
aaucggaccc auuuaaaccg gag                                               23


<210> 3051
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3051
cuccgguuua aauggguccg auu                                               23


<210> 3052
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3052
ucugggcaca ggcggaugga cagg                                              24


<210> 3053
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3053
ccuguccauc cgccugugcc caga                                              24


<210> 3054
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3054
ccagugacug agcuggagcc a                                                 21


<210> 3055
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3055
uggcuccagc ucagucacug g                                                 21


<210> 3056
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3056
aggauaggaa gaaugaagug cu                                                22


<210> 3057
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3057
agcacuucau ucuuccuauc cu                                                22


<210> 3058
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3058
aggagagugg auuccaggug gu                                                22


<210> 3059
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3059
accaccugga auccacucuc cu                                                22


<210> 3060
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3060
uccuccucua ccucauccca gu                                                22


<210> 3061
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3061
acugggauga gguagaggag ga                                                22


<210> 3062
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3062
ugagggguuu ggaaugggau gg                                                22


<210> 3063
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3063
ccaucccauu ccaaaccccu ca                                                22


<210> 3064
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3064
auccaguucu cugagggggc u                                                 21


<210> 3065
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3065
agcccccuca gagaacugga u                                                 21


<210> 3066
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3066
aaccccuaag gcaacuggau gg                                                22


<210> 3067
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3067
ccauccaguu gccuuagggg uu                                                22


<210> 3068
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3068
ucauccucgu cucccuccca g                                                 21


<210> 3069
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3069
cugggaggga gacgaggaug a                                                 21


<210> 3070
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3070
agggaagggg acgaggguug gg                                                22


<210> 3071
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3071
cccaacccuc guccccuucc cu                                                22


<210> 3072
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3072
aagaagagac ugagucaucg aau                                               23


<210> 3073
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3073
auucgaugac ucagucucuu cuu                                               23


<210> 3074
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3074
caauggcaca aacucauucu uga                                               23


<210> 3075
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3075
ucaagaauga guuugugcca uug                                               23


<210> 3076
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3076
acugaauccu cuuuuccuca g                                                 21


<210> 3077
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3077
cugaggaaaa gaggauucag u                                                 21


<210> 3078
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3078
ugggaugagg gauugaagug ga                                                22


<210> 3079
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3079
uccacuucaa ucccucaucc ca                                                22


<210> 3080
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3080
caggccauau ugugcugccu ca                                                22


<210> 3081
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3081
ugaggcagca caauauggcc ug                                                22


<210> 3082
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3082
uagcagcaca uaaugguuug ug                                                22


<210> 3083
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3083
cacaaaccau uaugugcugc ua                                                22


<210> 3084
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3084
cgaaucauua uuugcugcuc ua                                                22


<210> 3085
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3085
uagagcagca aauaaugauu cg                                                22


<210> 3086
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3086
uagcagcaca ucaugguuua ca                                                22


<210> 3087
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3087
uguaaaccau gaugugcugc ua                                                22


<210> 3088
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3088
ccaauauuac ugugcugcuu ua                                                22


<210> 3089
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3089
uaaagcagca caguaauauu gg                                                22


<210> 3090
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3090
cuagguaugg ucccagggau cc                                                22


<210> 3091
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3091
ggaucccugg gaccauaccu ag                                                22


<210> 3092
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3092
guguguggaa augcuucugc                                                   20


<210> 3093
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3093
gcagaagcau uuccacacac                                                   20


<210> 3094
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3094
gugugcggaa augcuucugc ua                                                22


<210> 3095
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3095
uagcagaagc auuuccgcac ac                                                22


<210> 3096
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3096
agcagcauug uacagggcua uca                                               23


<210> 3097
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3097
ugauagcccu guacaaugcu gcu                                               23


<210> 3098
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3098
aacuggcccu caaagucccg cu                                                22


<210> 3099
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3099
agcgggacuu ugagggccag uu                                                22


<210> 3100
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3100
cgggguuuug agggcgagau ga                                                22


<210> 3101
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3101
ucaucucgcc cucaaaaccc cg                                                22


<210> 3102
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3102
gcagggacag caaaggggug c                                                 21


<210> 3103
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3103
gcaccccuuu gcugucccug c                                                 21


<210> 3104
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3104
uucccuuugu cauccuucgc cu                                                22


<210> 3105
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3105
aggcgaagga ugacaaaggg aa                                                22


<210> 3106
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3106
auggccaaaa cugcaguuau uuu                                               23


<210> 3107
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3107
aaaauaacug caguuuuggc cau                                               23


<210> 3108
<211> 25
<212> RNA
<213> Homo sapiens

<400> 3108
aaaaaccaca auuacuuuug cacca                                             25


<210> 3109
<211> 25
<212> RNA
<213> Homo sapiens

<400> 3109
uggugcaaaa guaauugugg uuuuu                                             25


<210> 3110
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3110
caaaagugau cgugguuuuu g                                                 21


<210> 3111
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3111
caaaaaccac gaucacuuuu g                                                 21


<210> 3112
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3112
caaagacugc aauuacuuuu gcg                                               23


<210> 3113
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3113
cgcaaaagua auugcagucu uug                                               23


<210> 3114
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3114
aaaaguaacu gcgguuuuug ccu                                               23


<210> 3115
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3115
aggcaaaaac cgcaguuacu uuu                                               23


<210> 3116
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3116
ugccuggaac auaguaggga cu                                                22


<210> 3117
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3117
agucccuacu auguuccagg ca                                                22


<210> 3118
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3118
auaggacuca uauagugcca g                                                 21


<210> 3119
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3119
cuggcacuau augaguccua u                                                 21


<210> 3120
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3120
agacacuaua cgagucauau                                                   20


<210> 3121
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3121
auaugacucg uauagugucu                                                   20


<210> 3122
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3122
ugugacugca uuaugaaaau ucu                                               23


<210> 3123
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3123
agaauuuuca uaaugcaguc aca                                               23


<210> 3124
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3124
uggcuuuuaa cuuugauggc                                                   20


<210> 3125
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3125
gccaucaaag uuaaaagcca                                                   20


<210> 3126
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3126
cacagcaagu guagacaggc a                                                 21


<210> 3127
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3127
ugccugucua cacuugcugu g                                                 21


<210> 3128
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3128
ccugucugug ccugcuguac a                                                 21


<210> 3129
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3129
uguacagcag gcacagacag g                                                 21


<210> 3130
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3130
uaaauagagu aggcaaagga ca                                                22


<210> 3131
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3131
uguccuuugc cuacucuauu ua                                                22


<210> 3132
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3132
uccuuugccu auucuauuua ag                                                22


<210> 3133
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3133
cuuaaauaga auaggcaaag ga                                                22


<210> 3134
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3134
guugggacaa gaggacgguc uu                                                22


<210> 3135
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3135
aagaccgucc ucuuguccca ac                                                22


<210> 3136
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3136
cagagaauug uuuaauc                                                      17


<210> 3137
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3137
gauuaaacaa uucucug                                                      17


<210> 3138
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3138
uagaggaagc uguggagaga                                                   20


<210> 3139
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3139
ucucuccaca gcuuccucua                                                   20


<210> 3140
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3140
uccccuucug caggccugcu gg                                                22


<210> 3141
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3141
ccagcaggcc ugcagaaggg ga                                                22


<210> 3142
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3142
aucagggcuu guggaauggg aag                                               23


<210> 3143
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3143
cuucccauuc cacaagcccu gau                                               23


<210> 3144
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3144
ucuggcaagu aaaaaacucu cau                                               23


<210> 3145
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3145
augagaguuu uuuacuugcc aga                                               23


<210> 3146
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3146
ucgaggacug guggaagggc cuu                                               23


<210> 3147
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3147
aaggcccuuc caccaguccu cga                                               23


<210> 3148
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3148
uggguagaga aggagcucag agga                                              24


<210> 3149
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3149
uccucugagc uccuucucua ccca                                              24


<210> 3150
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3150
uaaagaacuc uuaaaaccca au                                                22


<210> 3151
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3151
auuggguuuu aagaguucuu ua                                                22


<210> 3152
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3152
ugauggauaa aagacuacau auu                                               23


<210> 3153
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3153
aauauguagu cuuuuaucca uca                                               23


<210> 3154
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3154
ugccuaggcu gagacugcag ug                                                22


<210> 3155
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3155
cacugcaguc ucagccuagg ca                                                22


<210> 3156
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3156
uggcccaacc uauucaguua gu                                                22


<210> 3157
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3157
acuaacugaa uagguugggc ca                                                22


<210> 3158
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3158
cugacugaau agguaggguc auu                                               23


<210> 3159
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3159
aaugacccua ccuauucagu cag                                               23


<210> 3160
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3160
ucuguagccu gggagcaaug gggu                                              24


<210> 3161
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3161
accccauugc ucccaggcua caga                                              24


<210> 3162
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3162
uaggagcuca acagaugccu guu                                               23


<210> 3163
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3163
aacaggcauc uguugagcuc cua                                               23


<210> 3164
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3164
gagggcgggu ggaggagga                                                    19


<210> 3165
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3165
uccuccucca cccgcccuc                                                    19


<210> 3166
<211> 25
<212> RNA
<213> Homo sapiens

<400> 3166
auaacauugu aaagcgcuuc uuucg                                             25


<210> 3167
<211> 25
<212> RNA
<213> Homo sapiens

<400> 3167
cgaaagaagc gcuuuacaau guuau                                             25


<210> 3168
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3168
agauauuuug aguguuugga auug                                              24


<210> 3169
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3169
caauuccaaa cacucaaaau aucu                                              24


<210> 3170
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3170
aacuccaaac acucaaaacu ca                                                22


<210> 3171
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3171
ugaguuuuga guguuuggag uu                                                22


<210> 3172
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3172
caugcuagga uagaaagaau gg                                                22


<210> 3173
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3173
ccauucuuuc uauccuagca ug                                                22


<210> 3174
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3174
gguugggcag ugaggagggu guga                                              24


<210> 3175
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3175
ucacacccuc cucacugccc aacc                                              24


<210> 3176
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3176
uggaaaaaac uggugugugc uu                                                22


<210> 3177
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3177
aagcacacac caguuuuuuc ca                                                22


<210> 3178
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3178
cuggggagau ccucgagguu gg                                                22


<210> 3179
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3179
ccaaccucga ggaucucccc ag                                                22


<210> 3180
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3180
caaccucgac gaucuccuca gc                                                22


<210> 3181
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3181
gcugaggaga ucgucgaggu ug                                                22


<210> 3182
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3182
ugaggagauc gucgagguug g                                                 21


<210> 3183
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3183
ccaaccucga cgaucuccuc a                                                 21


<210> 3184
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3184
caaccucgag gaucucccca gc                                                22


<210> 3185
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3185
gcuggggaga uccucgaggu ug                                                22


<210> 3186
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3186
gguggggcaa ugggaucagg u                                                 21


<210> 3187
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3187
accugauccc auugccccac c                                                 21


<210> 3188
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3188
ggggaaagcg aguagggaca uuu                                               23


<210> 3189
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3189
aaaugucccu acucgcuuuc ccc                                               23


<210> 3190
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3190
cagaagggga guugggagca ga                                                22


<210> 3191
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3191
ucugcuccca acuccccuuc ug                                                22


<210> 3192
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3192
ccaggcucug cagugggaac u                                                 21


<210> 3193
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3193
aguucccacu gcagagccug g                                                 21


<210> 3194
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3194
cucccacuuc cagaucuuuc u                                                 21


<210> 3195
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3195
agaaagaucu ggaaguggga g                                                 21


<210> 3196
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3196
aaagaucugg aagugggaga ca                                                22


<210> 3197
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3197
ugucucccac uuccagaucu uu                                                22


<210> 3198
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3198
cugcccuagu cuagcugaag cu                                                22


<210> 3199
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3199
agcuucagcu agacuagggc ag                                                22


<210> 3200
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3200
uucagccagg cuagugcagu cu                                                22


<210> 3201
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3201
agacugcacu agccuggcug aa                                                22


<210> 3202
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3202
uaggauuaca agugucggcc ac                                                22


<210> 3203
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3203
guggccgaca cuuguaaucc ua                                                22


<210> 3204
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3204
agagcugaga cuagaaagcc ca                                                22


<210> 3205
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3205
ugggcuuucu agucucagcu cu                                                22


<210> 3206
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3206
ggcuuucuag ucucagcucu cc                                                22


<210> 3207
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3207
ggagagcuga gacuagaaag cc                                                22


<210> 3208
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3208
cugauaagaa cagaggccca gau                                               23


<210> 3209
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3209
aucugggccu cuguucuuau cag                                               23


<210> 3210
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3210
ucccuacccc uccacucccc a                                                 21


<210> 3211
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3211
uggggagugg agggguaggg a                                                 21


<210> 3212
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3212
uuagggagua gaaggguggg gag                                               23


<210> 3213
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3213
cuccccaccc uucuacuccc uaa                                               23


<210> 3214
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3214
uauaaaauga gggcaguaag ac                                                22


<210> 3215
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3215
gucuuacugc ccucauuuua ua                                                22


<210> 3216
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3216
ugugacuuua agggaaaugg cg                                                22


<210> 3217
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3217
cgccauuucc cuuaaaguca ca                                                22


<210> 3218
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3218
agguggaugc aaugugaccu ca                                                22


<210> 3219
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3219
ugaggucaca uugcauccac cu                                                22


<210> 3220
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3220
cgcagacaau gccuacuggc cua                                               23


<210> 3221
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3221
uaggccagua ggcauugucu gcg                                               23


<210> 3222
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3222
gaguucuaca gucagac                                                      17


<210> 3223
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3223
gucugacugu agaacuc                                                      17


<210> 3224
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3224
uaggacugug cuuggcacau ag                                                22


<210> 3225
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3225
cuaugugcca agcacagucc ua                                                22


<210> 3226
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3226
cugggguucu gagacagaca gu                                                22


<210> 3227
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3227
acugucuguc ucagaacccc ag                                                22


<210> 3228
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3228
aaaggaggaa auaggcaggc ca                                                22


<210> 3229
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3229
uggccugccu auuuccuccu uu                                                22


<210> 3230
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3230
ugcccugccu guuuucuccu uu                                                22


<210> 3231
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3231
aaaggagaaa acaggcaggg ca                                                22


<210> 3232
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3232
uagugaguua gagaugcaga gcc                                               23


<210> 3233
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3233
ggcucugcau cucuaacuca cua                                               23


<210> 3234
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3234
acuggccugg gacuaccgg                                                    19


<210> 3235
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3235
ccgguagucc caggccagu                                                    19


<210> 3236
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3236
ugcacggcac uggggacacg u                                                 21


<210> 3237
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3237
acgugucccc agugccgugc a                                                 21


<210> 3238
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3238
uguguacaca cgugccaggc gcu                                               23


<210> 3239
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3239
agcgccuggc acguguguac aca                                               23


<210> 3240
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3240
ggggcgcggc cggaucg                                                      17


<210> 3241
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3241
cgauccggcc gcgcccc                                                      17


<210> 3242
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3242
agaaggggug aaauuuaaac gu                                                22


<210> 3243
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3243
acguuuaaau uucaccccuu cu                                                22


<210> 3244
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3244
aucgggcccu cggcgccgg                                                    19


<210> 3245
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3245
ccggcgccga gggcccgau                                                    19


<210> 3246
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3246
gcuucuguag uguaguc                                                      17


<210> 3247
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3247
gacuacacua cagaagc                                                      17


<210> 3248
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3248
gccucucucg gagucgcucg ga                                                22


<210> 3249
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3249
uccgagcgac uccgagagag gc                                                22


<210> 3250
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3250
aaagucucgc ucucugcccc uca                                               23


<210> 3251
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3251
ugaggggcag agagcgagac uuu                                               23


<210> 3252
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3252
ugaggggccu cagaccgagc uuuu                                              24


<210> 3253
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3253
aaaagcucgg ucugaggccc cuca                                              24


<210> 3254
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3254
agaagaaggc ggucggucug cgg                                               23


<210> 3255
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3255
ccgcagaccg accgccuucu ucu                                               23


<210> 3256
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3256
uuggccaugg ggcugcgcgg                                                   20


<210> 3257
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3257
ccgcgcagcc ccauggccaa                                                   20


<210> 3258
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3258
ccugggcagc guguggcuga agg                                               23


<210> 3259
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3259
ccuucagcca cacgcugccc agg                                               23


<210> 3260
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3260
agaggcuuug ugcggauacg ggg                                               23


<210> 3261
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3261
ccccguaucc gcacaaagcc ucu                                               23


<210> 3262
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3262
cccuuggguc ugauggggua g                                                 21


<210> 3263
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3263
cuaccccauc agacccaagg g                                                 21


<210> 3264
<211> 25
<212> RNA
<213> Homo sapiens

<400> 3264
ugccccaucu gugcccuggg uagga                                             25


<210> 3265
<211> 25
<212> RNA
<213> Homo sapiens

<400> 3265
uccuacccag ggcacagaug gggca                                             25


<210> 3266
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3266
uguggaaggu agacggccag aga                                               23


<210> 3267
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3267
ucucuggccg ucuaccuucc aca                                               23


<210> 3268
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3268
ucuggccagc uacgucccca                                                   20


<210> 3269
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3269
uggggacgua gcuggccaga                                                   20


<210> 3270
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3270
uggggacgua gcuggccaga cag                                               23


<210> 3271
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3271
cugucuggcc agcuacgucc cca                                               23


<210> 3272
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3272
cucucuggcc gucuaccuuc ca                                                22


<210> 3273
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3273
uggaagguag acggccagag ag                                                22


<210> 3274
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3274
ucugggaggu uguagcagug gaa                                               23


<210> 3275
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3275
uuccacugcu acaaccuccc aga                                               23


<210> 3276
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3276
uccugcguag gaucugagga gu                                                22


<210> 3277
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3277
acuccucaga uccuacgcag ga                                                22


<210> 3278
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3278
agcucugcug cucacuggca gu                                                22


<210> 3279
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3279
acugccagug agcagcagag cu                                                22


<210> 3280
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3280
ggccagccac caggagggcu g                                                 21


<210> 3281
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3281
cagcccuccu gguggcuggc c                                                 21


<210> 3282
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3282
cgcgccgggc ccggguu                                                      17


<210> 3283
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3283
aacccgggcc cggcgcg                                                      17


<210> 3284
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3284
ggaggcgcag gcucggaaag gcg                                               23


<210> 3285
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3285
cgccuuuccg agccugcgcc ucc                                               23


<210> 3286
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3286
guggaguccu ggggaaugga ga                                                22


<210> 3287
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3287
ucuccauucc ccaggacucc ac                                                22


<210> 3288
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3288
agggacugcc uuaggagaaa guu                                               23


<210> 3289
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3289
aacuuucucc uaaggcaguc ccu                                               23


<210> 3290
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3290
gggauaugaa gaaaaau                                                      17


<210> 3291
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3291
auuuuucuuc auauccc                                                      17


<210> 3292
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3292
uggaagggag aagagcuuua au                                                22


<210> 3293
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3293
auuaaagcuc uucucccuuc ca                                                22


<210> 3294
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3294
acuuuccuca cucccgugaa gu                                                22


<210> 3295
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3295
acuucacggg agugaggaaa gu                                                22


<210> 3296
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3296
uucgcgggcg aaggcaaagu c                                                 21


<210> 3297
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3297
gacuuugccu ucgcccgcga a                                                 21


<210> 3298
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3298
caucuggcau ccgucacaca ga                                                22


<210> 3299
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3299
ucugugugac ggaugccaga ug                                                22


<210> 3300
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3300
ugagggacag augccagaag ca                                                22


<210> 3301
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3301
ugcuucuggc aucugucccu ca                                                22


<210> 3302
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3302
aaacuaaucu cuacacugcu gc                                                22


<210> 3303
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3303
gcagcagugu agagauuagu uu                                                22


<210> 3304
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3304
gcaguagugu agagauuggu uu                                                22


<210> 3305
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3305
aaaccaaucu cuacacuacu gc                                                22


<210> 3306
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3306
gcugcaccgg agacugggua a                                                 21


<210> 3307
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3307
uuacccaguc uccggugcag c                                                 21


<210> 3308
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3308
uacccagucu ccggugcagc c                                                 21


<210> 3309
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3309
ggcugcaccg gagacugggu a                                                 21


<210> 3310
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3310
uguggacagu gagguagagg gagu                                              24


<210> 3311
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3311
acucccucua ccucacuguc caca                                              24


<210> 3312
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3312
agcuuuuggg aauucaggua gu                                                22


<210> 3313
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3313
acuaccugaa uucccaaaag cu                                                22


<210> 3314
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3314
accugaauua ccaaaagcuu u                                                 21


<210> 3315
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3315
aaagcuuuug guaauucagg u                                                 21


<210> 3316
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3316
auauaccugu ucggucucuu ua                                                22


<210> 3317
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3317
uaaagagacc gaacagguau au                                                22


<210> 3318
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3318
aggggaccaa agagauauau ag                                                22


<210> 3319
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3319
cuauauaucu cuuugguccc cu                                                22


<210> 3320
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3320
uuuguaugga uaugugugug uau                                               23


<210> 3321
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3321
auacacacac auauccauac aaa                                               23


<210> 3322
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3322
uguguuagaa uaggggcaau aa                                                22


<210> 3323
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3323
uuauugcccc uauucuaaca ca                                                22


<210> 3324
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3324
auugccucug uucuaacaca ag                                                22


<210> 3325
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3325
cuuguguuag aacagaggca au                                                22


<210> 3326
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3326
aagggcuucc ucucugcagg ac                                                22


<210> 3327
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3327
guccugcaga gaggaagccc uu                                                22


<210> 3328
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3328
ccugcagaga ggaagcccuu c                                                 21


<210> 3329
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3329
gaagggcuuc cucucugcag g                                                 21


<210> 3330
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3330
aggauuucag aaauacuggu gu                                                22


<210> 3331
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3331
acaccaguau uucugaaauc cu                                                22


<210> 3332
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3332
agauguaugg aaucuguaua uauc                                              24


<210> 3333
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3333
gauauauaca gauuccauac aucu                                              24


<210> 3334
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3334
cggggagaga acgcagugac gu                                                22


<210> 3335
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3335
acgucacugc guucucuccc cg                                                22


<210> 3336
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3336
uggggcggag cuuccggag                                                    19


<210> 3337
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3337
cuccggaagc uccgcccca                                                    19


<210> 3338
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3338
ucacgcggag agauggcuuu g                                                 21


<210> 3339
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3339
caaagccauc ucuccgcgug a                                                 21


<210> 3340
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3340
caggcgucug ucuacguggc uu                                                22


<210> 3341
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3341
aagccacgua gacagacgcc ug                                                22


<210> 3342
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3342
caccuugcgc uacucagguc ug                                                22


<210> 3343
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3343
cagaccugag uagcgcaagg ug                                                22


<210> 3344
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3344
aaucugagaa ggcgcacaag gu                                                22


<210> 3345
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3345
accuugugcg ccuucucaga uu                                                22


<210> 3346
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3346
aaggccuuuc ugaaccuuca ga                                                22


<210> 3347
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3347
ucugaagguu cagaaaggcc uu                                                22


<210> 3348
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3348
gugacaucac auauacggca gc                                                22


<210> 3349
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3349
gcugccguau augugauguc ac                                                22


<210> 3350
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3350
ucagaacaaa ugccgguucc caga                                              24


<210> 3351
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3351
ucugggaacc ggcauuuguu cuga                                              24


<210> 3352
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3352
ugagaaccac gucugcucug ag                                                22


<210> 3353
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3353
cucagagcag acgugguucu ca                                                22


<210> 3354
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3354
ucauauugcu ucuuucu                                                      17


<210> 3355
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3355
agaaagaagc aauauga                                                      17


<210> 3356
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3356
ugugacagau ugauaacuga aa                                                22


<210> 3357
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3357
uuucaguuau caaucuguca ca                                                22


<210> 3358
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3358
uggaguccag gaaucugcau uuu                                               23


<210> 3359
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3359
aaaaugcaga uuccuggacu cca                                               23


<210> 3360
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3360
aagcccuuac cccaaaaagu au                                                22


<210> 3361
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3361
auacuuuuug ggguaagggc uu                                                22


<210> 3362
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3362
aagcccuuac cccaaaaagc au                                                22


<210> 3363
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3363
augcuuuuug ggguaagggc uu                                                22


<210> 3364
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3364
uggaauguaa ggaagugugu gg                                                22


<210> 3365
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3365
ccacacacuu ccuuacauuc ca                                                22


<210> 3366
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3366
cuuaucagau uguauuguaa uu                                                22


<210> 3367
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3367
aauuacaaua caaucugaua ag                                                22


<210> 3368
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3368
uuauaauaca accugauaag ug                                                22


<210> 3369
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3369
cacuuaucag guuguauuau aa                                                22


<210> 3370
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3370
cuuagcaggu uguauuauca uu                                                22


<210> 3371
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3371
aaugauaaua caaccugcua ag                                                22


<210> 3372
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3372
auauaauaca accugcuaag ug                                                22


<210> 3373
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3373
cacuuagcag guuguauuau au                                                22


<210> 3374
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3374
cacuuagcag guuguauuau au                                                22


<210> 3375
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3375
auauaauaca accugcuaag ug                                                22


<210> 3376
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3376
auaauacaac cugcuaagug cu                                                22


<210> 3377
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3377
agcacuuagc agguuguauu au                                                22


<210> 3378
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3378
uuuggucccc uucaaccagc ug                                                22


<210> 3379
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3379
cagcugguug aaggggacca aa                                                22


<210> 3380
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3380
uuuggucccc uucaaccagc ua                                                22


<210> 3381
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3381
uagcugguug aaggggacca aa                                                22


<210> 3382
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3382
uguaaacauc cuugacugga ag                                                22


<210> 3383
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3383
cuuccaguca aggauguuua ca                                                22


<210> 3384
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3384
ugucaguuug ucaaauaccc ca                                                22


<210> 3385
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3385
ugggguauuu gacaaacuga ca                                                22


<210> 3386
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3386
cguguauuug acaagcugag uu                                                22


<210> 3387
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3387
aacucagcuu gucaaauaca cg                                                22


<210> 3388
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3388
uucacagugg cuaaguuccg c                                                 21


<210> 3389
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3389
gcggaacuua gccacuguga a                                                 21


<210> 3390
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3390
agggcuuagc ugcuugugag ca                                                22


<210> 3391
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3391
ugcucacaag cagcuaagcc cu                                                22


<210> 3392
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3392
aucacauugc cagggauuac c                                                 21


<210> 3393
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3393
gguaaucccu ggcaauguga u                                                 21


<210> 3394
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3394
uggguuccug gcaugcugau uu                                                22


<210> 3395
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3395
aaaucagcau gccaggaacc ca                                                22


<210> 3396
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3396
cuuucagucg gauguuuaca gc                                                22


<210> 3397
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3397
gcuguaaaca uccgacugaa ag                                                22


<210> 3398
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3398
ugccuacuga gcugauauca gu                                                22


<210> 3399
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3399
acugauauca gcucaguagg ca                                                22


<210> 3400
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3400
ugccuacuga gcugaaacac ag                                                22


<210> 3401
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3401
cuguguuuca gcucaguagg ca                                                22


<210> 3402
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3402
uggcucaguu cagcaggaac ag                                                22


<210> 3403
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3403
cuguuccugc ugaacugagc ca                                                22


<210> 3404
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3404
uucacagugg cuaaguucug c                                                 21


<210> 3405
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3405
gcagaacuua gccacuguga a                                                 21


<210> 3406
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3406
agagcuuagc ugauugguga ac                                                22


<210> 3407
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3407
guucaccaau cagcuaagcu cu                                                22


<210> 3408
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3408
uguaguguuu ccuacuuuau gga                                               23


<210> 3409
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3409
uccauaaagu aggaaacacu aca                                               23


<210> 3410
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3410
cauaaaguag aaagcacuac u                                                 21


<210> 3411
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3411
aguagugcuu ucuacuuuau g                                                 21


<210> 3412
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3412
ugaaggucua cugugugcca gg                                                22


<210> 3413
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3413
ccuggcacac aguagaccuu ca                                                22


<210> 3414
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3414
uuguacaugg uaggcuuuca uu                                                22


<210> 3415
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3415
aaugaaagcc uaccauguac aa                                                22


<210> 3416
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3416
cuggauggcu ccuccauguc u                                                 21


<210> 3417
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3417
agacauggag gagccaucca g                                                 21


<210> 3418
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3418
ucuuggagua ggucauuggg ugg                                               23


<210> 3419
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3419
ccacccaaug accuacucca aga                                               23


<210> 3420
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3420
cucaucugca aagaaguaag ug                                                22


<210> 3421
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3421
cacuuacuuc uuugcagaug ag                                                22


<210> 3422
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3422
aacuguuugc agaggaaacu ga                                                22


<210> 3423
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3423
ucaguuuccu cugcaaacag uu                                                22


<210> 3424
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3424
cuugguucag ggaggguccc ca                                                22


<210> 3425
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3425
uggggacccu cccugaacca ag                                                22


<210> 3426
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3426
aggaccuucc cugaaccaag ga                                                22


<210> 3427
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3427
uccuugguuc agggaagguc cu                                                22


<210> 3428
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3428
accuccugug ugcauggauu a                                                 21


<210> 3429
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3429
uaauccaugc acacaggagg u                                                 21


<210> 3430
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3430
uacccauugc auaucggagu ug                                                22


<210> 3431
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3431
caacuccgau augcaauggg ua                                                22


<210> 3432
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3432
aaagcugggu ugagaagg                                                     18


<210> 3433
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3433
ccuucucaac ccagcuuu                                                     18


<210> 3434
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3434
gguauccguu uggggauggu                                                   20


<210> 3435
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3435
accaucccca aacggauacc                                                   20


<210> 3436
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3436
gaaggcagca gugcuccccu gu                                                22


<210> 3437
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3437
acaggggagc acugcugccu uc                                                22


<210> 3438
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3438
ucagugcauc acagaacuuu gu                                                22


<210> 3439
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3439
acaaaguucu gugaugcacu ga                                                22


<210> 3440
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3440
aaguucuguu auacacucag gc                                                22


<210> 3441
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3441
gccugagugu auaacagaac uu                                                22


<210> 3442
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3442
cuggcccucu cugcccuucc gu                                                22


<210> 3443
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3443
acggaagggc agagagggcc ag                                                22


<210> 3444
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3444
cuagacugaa gcuccuugag g                                                 21


<210> 3445
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3445
ccucaaggag cuucagucua g                                                 21


<210> 3446
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3446
ucgaggagcu cacagucuag u                                                 21


<210> 3447
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3447
acuagacugu gagcuccucg a                                                 21


<210> 3448
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3448
cacauuacac ggucgaccuc u                                                 21


<210> 3449
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3449
agaggucgac cguguaaugu g                                                 21


<210> 3450
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3450
aggugguccg uggcgcguuc gc                                                22


<210> 3451
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3451
gcgaacgcgc cacggaccac cu                                                22


<210> 3452
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3452
cgcauccccu agggcauugg ugu                                               23


<210> 3453
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3453
acaccaaugc ccuaggggau gcg                                               23


<210> 3454
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3454
ccucugggcc cuuccuccag                                                   20


<210> 3455
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3455
cuggaggaag ggcccagagg                                                   20


<210> 3456
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3456
ccuaguaggu guccaguaag ugu                                               23


<210> 3457
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3457
acacuuacug gacaccuacu agg                                               23


<210> 3458
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3458
acggugcugg auguggccuu u                                                 21


<210> 3459
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3459
aaaggccaca uccagcaccg u                                                 21


<210> 3460
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3460
ucagcaccag gauauuguug gag                                               23


<210> 3461
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3461
cuccaacaau auccuggugc uga                                               23


<210> 3462
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3462
ucaacaaaau cacugaugcu gga                                               23


<210> 3463
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3463
uccagcauca gugauuuugu uga                                               23


<210> 3464
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3464
aacaauaucc uggugcugag ug                                                22


<210> 3465
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3465
cacucagcac caggauauug uu                                                22


<210> 3466
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3466
ggcagguucu cacccucucu agg                                               23


<210> 3467
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3467
ccuagagagg gugagaaccu gcc                                               23


<210> 3468
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3468
gacacgggcg acagcugcgg ccc                                               23


<210> 3469
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3469
gggccgcagc ugucgcccgu guc                                               23


<210> 3470
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3470
auguaugugu gcaugugcau g                                                 21


<210> 3471
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3471
caugcacaug cacacauaca u                                                 21


<210> 3472
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3472
uauacaaggg cagacucucu cu                                                22


<210> 3473
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3473
agagagaguc ugcccuugua ua                                                22


<210> 3474
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3474
ggcggcggcg gaggcggggg                                                   20


<210> 3475
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3475
cccccgccuc cgccgccgcc                                                   20


<210> 3476
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3476
gcaggugcuc acuuguccuc cu                                                22


<210> 3477
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3477
aggaggacaa gugagcaccu gc                                                22


<210> 3478
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3478
ggggccuggc ggugggcgg                                                    19


<210> 3479
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3479
ccgcccaccg ccaggcccc                                                    19


<210> 3480
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3480
gcccaaaggu gaauuuuuug gg                                                22


<210> 3481
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3481
cccaaaaaau ucaccuuugg gc                                                22


<210> 3482
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3482
caaagaauuc uccuuuuggg cu                                                22


<210> 3483
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3483
agcccaaaag gagaauucuu ug                                                22


<210> 3484
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3484
cugcaaugua agcacuucuu ac                                                22


<210> 3485
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3485
guaagaagug cuuacauugc ag                                                22


<210> 3486
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3486
aaaagugcuu acagugcagg uag                                               23


<210> 3487
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3487
cuaccugcac uguaagcacu uuu                                               23


<210> 3488
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3488
acuguaguau gggcacuucc ag                                                22


<210> 3489
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3489
cuggaagugc ccauacuaca gu                                                22


<210> 3490
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3490
caaagugcuc auagugcagg uag                                               23


<210> 3491
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3491
cuaccugcac uaugagcacu uug                                               23


<210> 3492
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3492
gggguauugu uuccgcugcc agg                                               23


<210> 3493
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3493
ccuggcagcg gaaacaauac ccc                                               23


<210> 3494
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3494
uagcagcggg aacaguucug cag                                               23


<210> 3495
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3495
cugcagaacu guucccgcug cua                                               23


<210> 3496
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3496
cgagccucaa gcaagggacu u                                                 21


<210> 3497
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3497
aagucccuug cuugaggcuc g                                                 21


<210> 3498
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3498
uagucccuuc cuugaagcgg uc                                                22


<210> 3499
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3499
gaccgcuuca aggaagggac ua                                                22


<210> 3500
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3500
acuggacuug gagucagaag g                                                 21


<210> 3501
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3501
ccuucugacu ccaaguccag u                                                 21


<210> 3502
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3502
cuccugacuc cagguccugu gu                                                22


<210> 3503
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3503
acacaggacc uggagucagg ag                                                22


<210> 3504
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3504
uuuguucguu cggcucgcgu ga                                                22


<210> 3505
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3505
ucacgcgagc cgaacgaaca aa                                                22


<210> 3506
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3506
acggauguuu gagcaugugc ua                                                22


<210> 3507
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3507
uagcacaugc ucaaacaucc gu                                                22


<210> 3508
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3508
ucaaaugcuc agacuccugu ggu                                               23


<210> 3509
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3509
accacaggag ucugagcauu uga                                               23


<210> 3510
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3510
cggcaacaag aaacugccug ag                                                22


<210> 3511
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3511
cucaggcagu uucuuguugc cg                                                22


<210> 3512
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3512
uagguaguuu cauguuguug gg                                                22


<210> 3513
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3513
cccaacaaca ugaaacuacc ua                                                22


<210> 3514
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3514
caauguuucc acagugcauc ac                                                22


<210> 3515
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3515
gugaugcacu guggaaacau ug                                                22


<210> 3516
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3516
gugcauugua guugcauugc a                                                 21


<210> 3517
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3517
ugcaaugcaa cuacaaugca c                                                 21


<210> 3518
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3518
aucccaccuc ugccacca                                                     18


<210> 3519
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3519
ugguggcaga ggugggau                                                     18


<210> 3520
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3520
aucccaccac ugccaccau                                                    19


<210> 3521
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3521
augguggcag uggugggau                                                    19


<210> 3522
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3522
accuuccucu ccaugggucu uu                                                22


<210> 3523
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3523
aaagacccau ggagaggaag gu                                                22


<210> 3524
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3524
aaagacccau ugaggagaag gu                                                22


<210> 3525
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3525
accuucuccu caaugggucu uu                                                22


<210> 3526
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3526
aauguagaga uugaucaaaa u                                                 21


<210> 3527
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3527
auuuugauca aucucuacau u                                                 21


<210> 3528
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3528
acggaauaug uauacggaau aua                                               23


<210> 3529
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3529
uauauuccgu auacauauuc cgu                                               23


<210> 3530
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3530
agagcucaca gcuguccuuc ucua                                              24


<210> 3531
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3531
uagagaagga cagcugugag cucu                                              24


<210> 3532
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3532
aucaaauaag gacuagucug ca                                                22


<210> 3533
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3533
ugcagacuag uccuuauuug au                                                22


<210> 3534
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3534
augagacuca uguaaaacau cuu                                               23


<210> 3535
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3535
aagauguuuu acaugagucu cau                                               23


<210> 3536
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3536
auggaaugua uauacggaau a                                                 21


<210> 3537
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3537
uauuccguau auacauucca u                                                 21


<210> 3538
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3538
auuguagaac cuaagauugg cc                                                22


<210> 3539
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3539
ggccaaucuu agguucuaca au                                                22


<210> 3540
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3540
caucucuaag gaacuccccc aa                                                22


<210> 3541
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3541
uugggggagu uccuuagaga ug                                                22


<210> 3542
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3542
uauggggcuu cuguagagau uuc                                               23


<210> 3543
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3543
gaaaucucua cagaagcccc aua                                               23


<210> 3544
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3544
ccguguuucc cccacgcuuu                                                   20


<210> 3545
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3545
aaagcguggg ggaaacacgg                                                   20


<210> 3546
<211> 15
<212> RNA
<213> Homo sapiens

<400> 3546
aggagauccu ggguu                                                        15


<210> 3547
<211> 15
<212> RNA
<213> Homo sapiens

<400> 3547
aacccaggau cuccu                                                        15


<210> 3548
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3548
cucgugggcu cuggccacgg cc                                                22


<210> 3549
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3549
ggccguggcc agagcccacg ag                                                22


<210> 3550
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3550
caguggccag agcccugcag ug                                                22


<210> 3551
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3551
cacugcaggg cucuggccac ug                                                22


<210> 3552
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3552
cugcagaguu uguacggacc gg                                                22


<210> 3553
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3553
ccgguccgua caaacucugc ag                                                22


<210> 3554
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3554
uccguacaaa cucugcugug                                                   20


<210> 3555
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3555
cacagcagag uuuguacgga                                                   20


<210> 3556
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3556
cuucccccca guaaucuuca uc                                                22


<210> 3557
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3557
gaugaagauu acugggggga ag                                                22


<210> 3558
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3558
ugaggauaug gcagggaagg gga                                               23


<210> 3559
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3559
uccccuuccc ugccauaucc uca                                               23


<210> 3560
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3560
uuuugcauga cccugggagu agg                                               23


<210> 3561
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3561
ccuacuccca gggucaugca aaa                                               23


<210> 3562
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3562
gacucacuca caggauugug ca                                                22


<210> 3563
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3563
ugcacaaucc ugugagugag uc                                                22


<210> 3564
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3564
acacagugcu ucauccacua cu                                                22


<210> 3565
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3565
aguaguggau gaagcacugu gu                                                22


<210> 3566
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3566
uaguggauga ugcacucugu gc                                                22


<210> 3567
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3567
gcacagagug caucauccac ua                                                22


<210> 3568
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3568
ugaugauaca gguggaggua g                                                 21


<210> 3569
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3569
cuaccuccac cuguaucauc a                                                 21


<210> 3570
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3570
cuacuucuac cuguguuauc au                                                22


<210> 3571
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3571
augauaacac agguagaagu ag                                                22


<210> 3572
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3572
ugcgacauug gaaguaguau ca                                                22


<210> 3573
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3573
ugauacuacu uccaaugucg ca                                                22


<210> 3574
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3574
uuagaccuag uacacguccu u                                                 21


<210> 3575
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3575
aaggacgugu acuaggucua a                                                 21


<210> 3576
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3576
uuuccuaccc uaccugaaga cu                                                22


<210> 3577
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3577
agucuucagg uaggguagga aa                                                22


<210> 3578
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3578
aucuguaaga gaaaguaaau ga                                                22


<210> 3579
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3579
ucauuuacuu ucucuuacag au                                                22


<210> 3580
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3580
cccggacagg cguucgugcg acgu                                              24


<210> 3581
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3581
acgucgcacg aacgccuguc cggg                                              24


<210> 3582
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3582
accuggaccc agcguagaca aag                                               23


<210> 3583
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3583
cuuugucuac gcugggucca ggu                                               23


<210> 3584
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3584
accaagucug cgucauccuc uc                                                22


<210> 3585
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3585
gagaggauga cgcagacuug gu                                                22


<210> 3586
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3586
aguggaugau ggagacucgg uac                                               23


<210> 3587
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3587
guaccgaguc uccaucaucc acu                                               23


<210> 3588
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3588
guuccacacu gacacugcag aagu                                              24


<210> 3589
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3589
acuucugcag ugucagugug gaac                                              24


<210> 3590
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3590
ccugcugguc aggaguggau acug                                              24


<210> 3591
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3591
caguauccac uccugaccag cagg                                              24


<210> 3592
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3592
gagggucuug ggagggaugu gac                                               23


<210> 3593
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3593
gucacauccc ucccaagacc cuc                                               23


<210> 3594
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3594
auauacaggg ggagacucuu au                                                22


<210> 3595
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3595
auaagagucu cccccuguau au                                                22


<210> 3596
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3596
auauacaggg ggagacucuc au                                                22


<210> 3597
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3597
augagagucu cccccuguau au                                                22


<210> 3598
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3598
agaggauacc cuuuguaugu u                                                 21


<210> 3599
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3599
aacauacaaa ggguauccuc u                                                 21


<210> 3600
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3600
ucuacaaagg aaagcgcuuu cu                                                22


<210> 3601
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3601
agaaagcgcu uuccuuugua ga                                                22


<210> 3602
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3602
ucaaaacuga ggggcauuuu cu                                                22


<210> 3603
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3603
agaaaaugcc ccucaguuuu ga                                                22


<210> 3604
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3604
uucuccaaaa gaaagcacuu ucug                                              24


<210> 3605
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3605
cagaaagugc uuucuuuugg agaa                                              24


<210> 3606
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3606
uucucgagga aagaagcacu uuc                                               23


<210> 3607
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3607
gaaagugcuu cuuuccucga gaa                                               23


<210> 3608
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3608
ccucuagaug gaagcacugu cu                                                22


<210> 3609
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3609
agacagugcu uccaucuaga gg                                                22


<210> 3610
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3610
aucgugcauc ccuuuagagu gu                                                22


<210> 3611
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3611
acacucuaaa gggaugcacg au                                                22


<210> 3612
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3612
aucgugcauc ccuuuagagu gu                                                22


<210> 3613
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3613
acacucuaaa gggaugcacg au                                                22


<210> 3614
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3614
aucgugcauc cuuuuagagu gu                                                22


<210> 3615
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3615
acacucuaaa aggaugcacg au                                                22


<210> 3616
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3616
caaagcgcuc cccuuuagag gu                                                22


<210> 3617
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3617
accucuaaag gggagcgcuu ug                                                22


<210> 3618
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3618
caaagcgcuu cucuuuagag ugu                                               23


<210> 3619
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3619
acacucuaaa gagaagcgcu uug                                               23


<210> 3620
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3620
ucucuggagg gaagcacuuu cug                                               23


<210> 3621
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3621
cagaaagugc uucccuccag aga                                               23


<210> 3622
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3622
gaaagcgcuu cucuuuagag g                                                 21


<210> 3623
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3623
ccucuaaaga gaagcgcuuu c                                                 21


<210> 3624
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3624
cucuagaggg aagcacuuuc uc                                                22


<210> 3625
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3625
gagaaagugc uucccucuag ag                                                22


<210> 3626
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3626
aaagugcauc cuuuuagagu gu                                                22


<210> 3627
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3627
acacucuaaa aggaugcacu uu                                                22


<210> 3628
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3628
cucuagaggg aagcgcuuuc ug                                                22


<210> 3629
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3629
cagaaagcgc uucccucuag ag                                                22


<210> 3630
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3630
caaagugccu cccuuuagag ug                                                22


<210> 3631
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3631
cacucuaaag ggaggcacuu ug                                                22


<210> 3632
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3632
aagugccucc uuuuagagug uu                                                22


<210> 3633
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3633
aacacucuaa aaggaggcac uu                                                22


<210> 3634
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3634
uucuccaaaa gggagcacuu uc                                                22


<210> 3635
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3635
gaaagugcuc ccuuuuggag aa                                                22


<210> 3636
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3636
aaagugcuuc ccuuuggacu gu                                                22


<210> 3637
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3637
acaguccaaa gggaagcacu uu                                                22


<210> 3638
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3638
cuccagaggg aaguacuuuc u                                                 21


<210> 3639
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3639
agaaaguacu ucccucugga g                                                 21


<210> 3640
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3640
acaaagugcu ucccuuuaga gu                                                22


<210> 3641
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3641
acucuaaagg gaagcacuuu gu                                                22


<210> 3642
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3642
cuacaaaggg aagcacuuuc uc                                                22


<210> 3643
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3643
gagaaagugc uucccuuugu ag                                                22


<210> 3644
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3644
gaaggcgcuu cccuuuagag cg                                                22


<210> 3645
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3645
cgcucuaaag ggaagcgccu uc                                                22


<210> 3646
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3646
cuccagaggg augcacuuuc u                                                 21


<210> 3647
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3647
agaaagugca ucccucugga g                                                 21


<210> 3648
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3648
cucuagaggg aagcacuuuc ug                                                22


<210> 3649
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3649
cagaaagugc uucccucuag ag                                                22


<210> 3650
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3650
gaaagugcuu ccuuuuagag gc                                                22


<210> 3651
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3651
gccucuaaaa ggaagcacuu uc                                                22


<210> 3652
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3652
cucuugaggg aagcacuuuc ugu                                               23


<210> 3653
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3653
acagaaagug cuucccucaa gag                                               23


<210> 3654
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3654
acuggacuua gggucagaag gc                                                22


<210> 3655
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3655
gccuucugac ccuaagucca gu                                                22


<210> 3656
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3656
aaacaaacau ggugcacuuc uu                                                22


<210> 3657
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3657
aagaagugca ccauguuugu uu                                                22


<210> 3658
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3658
gaaguugccc auguuauuuu cg                                                22


<210> 3659
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3659
cgaaaauaac augggcaacu uc                                                22


<210> 3660
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3660
aaucauucac ggacaacacu u                                                 21


<210> 3661
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3661
aaguguuguc cgugaaugau u                                                 21


<210> 3662
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3662
gaaguuguuc gugguggauu cg                                                22


<210> 3663
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3663
cgaauccacc acgaacaacu uc                                                22


<210> 3664
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3664
ccuccguguu accuguccuc uag                                               23


<210> 3665
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3665
cuagaggaca gguaacacgg agg                                               23


<210> 3666
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3666
ugaggaugga uagcaaggaa gcc                                               23


<210> 3667
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3667
ggcuuccuug cuauccaucc uca                                               23


<210> 3668
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3668
uucagauccc agcggugccu cu                                                22


<210> 3669
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3669
agaggcaccg cugggaucug aa                                                22


<210> 3670
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3670
guccuaggag gcuccucug                                                    19


<210> 3671
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3671
cagaggagcc uccuaggac                                                    19


<210> 3672
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3672
caauucucaa aggagccucc c                                                 21


<210> 3673
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3673
gggaggcucc uuugagaauu g                                                 21


<210> 3674
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3674
guuggggugc aggggucugc u                                                 21


<210> 3675
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3675
agcagacccc ugcaccccaa c                                                 21


<210> 3676
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3676
uuuccggcuc gcgugggugu gu                                                22


<210> 3677
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3677
acacacccac gcgagccgga aa                                                22


<210> 3678
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3678
ugagugugug ugugugagug ugu                                               23


<210> 3679
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3679
acacacucac acacacacac uca                                               23


<210> 3680
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3680
agugggaggc cagggcacgg ca                                                22


<210> 3681
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3681
ugccgugccc uggccuccca cu                                                22


<210> 3682
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3682
ugagcccugu ccucccgcag                                                   20


<210> 3683
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3683
cugcgggagg acagggcuca                                                   20


<210> 3684
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3684
aagugccgcc aucuuuugag ugu                                               23


<210> 3685
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3685
acacucaaaa gauggcggca cuu                                               23


<210> 3686
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3686
acucaaacug ugggggcacu                                                   20


<210> 3687
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3687
agugccccca caguuugagu                                                   20


<210> 3688
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3688
aagugccccc acaguuugag ugc                                               23


<210> 3689
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3689
gcacucaaac ugugggggca cuu                                               23


<210> 3690
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3690
acucaaaaga uggcggcacu uu                                                22


<210> 3691
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3691
aaagugccgc caucuuuuga gu                                                22


<210> 3692
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3692
aaaccugugu uguucaagag uc                                                22


<210> 3693
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3693
gacucuugaa caacacaggu uu                                                22


<210> 3694
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3694
acaguagagg gaggaaucgc ag                                                22


<210> 3695
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3695
cugcgauucc ucccucuacu gu                                                22


<210> 3696
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3696
gugaaauguu uaggaccacu ag                                                22


<210> 3697
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3697
cuaguggucc uaaacauuuc ac                                                22


<210> 3698
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3698
uugaacuguu aagaaccacu gga                                               23


<210> 3699
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3699
uccagugguu cuuaacaguu caa                                               23


<210> 3700
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3700
uagugguccu aaacauuuca ca                                                22


<210> 3701
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3701
ugugaaaugu uuaggaccac ua                                                22


<210> 3702
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3702
ugcaggacca agaugagccc u                                                 21


<210> 3703
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3703
agggcucauc uugguccugc a                                                 21


<210> 3704
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3704
cucccacaug caggguuugc a                                                 21


<210> 3705
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3705
ugcaaacccu gcauguggga g                                                 21


<210> 3706
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3706
caucccuugc augguggagg g                                                 21


<210> 3707
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3707
cccuccacca ugcaagggau g                                                 21


<210> 3708
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3708
aaaaugaaau gagcccagcc ca                                                22


<210> 3709
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3709
ugggcugggc ucauuucauu uu                                                22


<210> 3710
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3710
agccgcgggg aucgccgagg g                                                 21


<210> 3711
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3711
cccucggcga uccccgcggc u                                                 21


<210> 3712
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3712
agggaccuga gugucuaag                                                    19


<210> 3713
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3713
cuuagacacu caggucccu                                                    19


<210> 3714
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3714
aggugugucu guagagucc                                                    19


<210> 3715
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3715
ggacucuaca gacacaccu                                                    19


<210> 3716
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3716
cauagcccgg ucgcugguac auga                                              24


<210> 3717
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3717
ucauguacca gcgaccgggc uaug                                              24


<210> 3718
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3718
cggcuggagg ugugagga                                                     18


<210> 3719
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3719
uccucacacc uccagccg                                                     18


<210> 3720
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3720
cuaagaaguu gacugaag                                                     18


<210> 3721
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3721
cuucagucaa cuucuuag                                                     18


<210> 3722
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3722
gacuggacaa gcugaggaa                                                    19


<210> 3723
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3723
uuccucagcu uguccaguc                                                    19


<210> 3724
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3724
gcuugucgcu gcgguguugc u                                                 21


<210> 3725
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3725
agcaacaccg cagcgacaag c                                                 21


<210> 3726
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3726
ggcgggugcg ggggugg                                                      17


<210> 3727
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3727
ccacccccgc acccgcc                                                      17


<210> 3728
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3728
ugugucccau uauuggugau u                                                 21


<210> 3729
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3729
aaucaccaau aaugggacac a                                                 21


<210> 3730
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3730
uuuaagaaaa caccauggag au                                                22


<210> 3731
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3731
aucuccaugg uguuuucuua aa                                                22


<210> 3732
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3732
gcuauuucac gacaccaggg uu                                                22


<210> 3733
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3733
aacccuggug ucgugaaaua gc                                                22


<210> 3734
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3734
agcugguguu gugaaucagg ccg                                               23


<210> 3735
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3735
cggccugauu cacaacacca gcu                                               23


<210> 3736
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3736
aauaauacau gguugaucuu u                                                 21


<210> 3737
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3737
aaagaucaac cauguauuau u                                                 21


<210> 3738
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3738
agaucgaccg uguuauauuc gc                                                22


<210> 3739
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3739
gcgaauauaa cacggucgau cu                                                22


<210> 3740
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3740
aaucaugugc agugccaaua ug                                                22


<210> 3741
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3741
cauauuggca cugcacauga uu                                                22


<210> 3742
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3742
uuuggcacua gcacauuuuu gcu                                               23


<210> 3743
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3743
agcaaaaaug ugcuagugcc aaa                                               23


<210> 3744
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3744
uccuguacug agcugccccg ag                                                22


<210> 3745
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3745
cucggggcag cucaguacag ga                                                22


<210> 3746
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3746
gcuacuucac aacaccaggg cc                                                22


<210> 3747
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3747
ggcccuggug uugugaagua gc                                                22


<210> 3748
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3748
caucaucguc ucaaaugagu cu                                                22


<210> 3749
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3749
agacucauuu gagacgauga ug                                                22


<210> 3750
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3750
acuccauuug uuuugaugau gga                                               23


<210> 3751
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3751
uccaucauca aaacaaaugg agu                                               23


<210> 3752
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3752
cuccuacaua uuagcauuaa ca                                                22


<210> 3753
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3753
uguuaaugcu aauauguagg ag                                                22


<210> 3754
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3754
uuaaugcuaa ucgugauagg ggu                                               23


<210> 3755
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3755
accccuauca cgauuagcau uaa                                               23


<210> 3756
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3756
agaucagaag gugauugugg cu                                                22


<210> 3757
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3757
agccacaauc accuucugau cu                                                22


<210> 3758
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3758
uacugcagac guggcaauca ug                                                22


<210> 3759
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3759
caugauugcc acgucugcag ua                                                22


<210> 3760
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3760
guuagggcca acaucucuug g                                                 21


<210> 3761
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3761
ccaagagaug uuggcccuaa c                                                 21


<210> 3762
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3762
aacauagagg aaauuccacg u                                                 21


<210> 3763
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3763
acguggaauu uccucuaugu u                                                 21


<210> 3764
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3764
gguggauauu ccuucuaugu u                                                 21


<210> 3765
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3765
aacauagaag gaauauccac c                                                 21


<210> 3766
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3766
ucauagcccu guacaaugcu gcu                                               23


<210> 3767
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3767
agcagcauug uacagggcua uga                                               23


<210> 3768
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3768
uaacacuguc ugguaaagau gg                                                22


<210> 3769
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3769
ccaucuuuac cagacagugu ua                                                22


<210> 3770
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3770
caucuuccag uacaguguug ga                                                22


<210> 3771
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3771
uccaacacug uacuggaaga ug                                                22


<210> 3772
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3772
aacuggccua caaaguccca gu                                                22


<210> 3773
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3773
acugggacuu uguaggccag uu                                                22


<210> 3774
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3774
ugggucuuug cgggcgagau ga                                                22


<210> 3775
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3775
ucaucucgcc cgcaaagacc ca                                                22


<210> 3776
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3776
augaccuaug aauugacaga c                                                 21


<210> 3777
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3777
gucugucaau ucauagguca u                                                 21


<210> 3778
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3778
aagcugccag uugaagaacu gu                                                22


<210> 3779
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3779
acaguucuuc aacuggcagc uu                                                22


<210> 3780
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3780
aguucuucag uggcaagcuu ua                                                22


<210> 3781
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3781
uaaagcuugc cacugaagaa cu                                                22


<210> 3782
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3782
acagauucga uucuagggga au                                                22


<210> 3783
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3783
auuccccuag aaucgaaucu gu                                                22


<210> 3784
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3784
uacccuguag aaccgaauuu gug                                               23


<210> 3785
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3785
cacaaauucg guucuacagg gua                                               23


<210> 3786
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3786
uagcagcacg uaaauauugg cg                                                22


<210> 3787
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3787
cgccaauauu uacgugcugc ua                                                22


<210> 3788
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3788
ugagaugaag cacuguagcu c                                                 21


<210> 3789
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3789
gagcuacagu gcuucaucuc a                                                 21


<210> 3790
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3790
ggugcagugc ugcaucucug gu                                                22


<210> 3791
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3791
accagagaug cagcacugca cc                                                22


<210> 3792
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3792
uugcucacug uucuucccua g                                                 21


<210> 3793
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3793
cuagggaaga acagugagca a                                                 21


<210> 3794
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3794
cagggucagc ugagcaug                                                     18


<210> 3795
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3795
caugcucagc ugacccug                                                     18


<210> 3796
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3796
aagcauucuu ucauugguug g                                                 21


<210> 3797
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3797
ccaaccaaug aaagaaugcu u                                                 21


<210> 3798
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3798
ccgucgccgc cacccgagcc g                                                 21


<210> 3799
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3799
cggcucgggu ggcggcgacg g                                                 21


<210> 3800
<211> 27
<212> RNA
<213> Homo sapiens

<400> 3800
cacuguaggu gauggugaga gugggca                                           27


<210> 3801
<211> 27
<212> RNA
<213> Homo sapiens

<400> 3801
ugcccacucu caccaucacc uacagug                                           27


<210> 3802
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3802
gggaugguag accggugacg ugc                                               23


<210> 3803
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3803
gcacgucacc ggucuaccau ccc                                               23


<210> 3804
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3804
uaggacacau ggucuacuuc u                                                 21


<210> 3805
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3805
agaaguagac cauguguccu a                                                 21


<210> 3806
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3806
cuccugagcc auucugagcc uc                                                22


<210> 3807
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3807
gaggcucaga auggcucagg ag                                                22


<210> 3808
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3808
gugccagcug caguggggga g                                                 21


<210> 3809
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3809
cucccccacu gcagcuggca c                                                 21


<210> 3810
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3810
cccggagcca ggaugcagcu c                                                 21


<210> 3811
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3811
gagcugcauc cuggcuccgg g                                                 21


<210> 3812
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3812
ucguggccug gucuccauua u                                                 21


<210> 3813
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3813
auaauggaga ccaggccacg a                                                 21


<210> 3814
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3814
ucugcagggu uugcuuugag                                                   20


<210> 3815
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3815
cucaaagcaa acccugcaga                                                   20


<210> 3816
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3816
uguucaugua gauguuuaag c                                                 21


<210> 3817
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3817
gcuuaaacau cuacaugaac a                                                 21


<210> 3818
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3818
ucagcuggcc cucauuuc                                                     18


<210> 3819
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3819
gaaaugaggg ccagcuga                                                     18


<210> 3820
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3820
uggcagggag gcugggaggg g                                                 21


<210> 3821
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3821
ccccucccag ccucccugcc a                                                 21


<210> 3822
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3822
ucacuguuca gacaggcgga                                                   20


<210> 3823
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3823
uccgccuguc ugaacaguga                                                   20


<210> 3824
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3824
ccccaccucc ucucuccuca g                                                 21


<210> 3825
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3825
cugaggagag aggagguggg g                                                 21


<210> 3826
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3826
gugaggacuc gggaggugg                                                    19


<210> 3827
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3827
ccaccucccg aguccucac                                                    19


<210> 3828
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3828
ugagccccug ugccgccccc ag                                                22


<210> 3829
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3829
cugggggcgg cacaggggcu ca                                                22


<210> 3830
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3830
guggguacgg cccagugggg gg                                                22


<210> 3831
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3831
ccccccacug ggccguaccc ac                                                22


<210> 3832
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3832
ucaccagccc uguguucccu ag                                                22


<210> 3833
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3833
cuagggaaca cagggcuggu ga                                                22


<210> 3834
<211> 26
<212> RNA
<213> Homo sapiens

<400> 3834
gugagggcau gcaggccugg augggg                                            26


<210> 3835
<211> 26
<212> RNA
<213> Homo sapiens

<400> 3835
ccccauccag gccugcaugc ccucac                                            26


<210> 3836
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3836
cucucaccac ugcccuccca cag                                               23


<210> 3837
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3837
cugugggagg gcagugguga gag                                               23


<210> 3838
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3838
guggguaggg uuugggggag agcg                                              24


<210> 3839
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3839
cgcucucccc caaacccuac ccac                                              24


<210> 3840
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3840
gugucugggc ggacagcugc                                                   20


<210> 3841
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3841
gcagcugucc gcccagacac                                                   20


<210> 3842
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3842
cuuccucguc ugucugcccc                                                   20


<210> 3843
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3843
ggggcagaca gacgaggaag                                                   20


<210> 3844
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3844
gugaguggga gccccagugu gug                                               23


<210> 3845
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3845
cacacacugg ggcucccacu cac                                               23


<210> 3846
<211> 27
<212> RNA
<213> Homo sapiens

<400> 3846
accuucuugu auaagcacug ugcuaaa                                           27


<210> 3847
<211> 27
<212> RNA
<213> Homo sapiens

<400> 3847
uuuagcacag ugcuuauaca agaaggu                                           27


<210> 3848
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3848
ggcgacaaaa cgagacccug uc                                                22


<210> 3849
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3849
gacagggucu cguuuugucg cc                                                22


<210> 3850
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3850
uugcuugaac ccaggaagug ga                                                22


<210> 3851
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3851
uccacuuccu ggguucaagc aa                                                22


<210> 3852
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3852
ggagauggag guugcagug                                                    19


<210> 3853
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3853
cacugcaacc uccaucucc                                                    19


<210> 3854
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3854
accacugcac uccagccuga g                                                 21


<210> 3855
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3855
cucaggcugg agugcagugg u                                                 21


<210> 3856
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3856
ggugguugag gcugcaguaa gu                                                22


<210> 3857
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3857
acuuacugca gccucaacca cc                                                22


<210> 3858
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3858
ucgccuccuc cucuccc                                                      17


<210> 3859
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3859
gggagaggag gaggcga                                                      17


<210> 3860
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3860
ucuauacaga cccuggcuuu uc                                                22


<210> 3861
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3861
gaaaagccag ggucuguaua ga                                                22


<210> 3862
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3862
ucugggcaac aaagugagac cu                                                22


<210> 3863
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3863
aggucucacu uuguugccca ga                                                22


<210> 3864
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3864
gaucucacuu uguugcccag g                                                 21


<210> 3865
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3865
ccugggcaac aaagugagau c                                                 21


<210> 3866
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3866
ucgcgccccg gcucccguuc                                                   20


<210> 3867
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3867
gaacgggagc cggggcgcga                                                   20


<210> 3868
<211> 25
<212> RNA
<213> Homo sapiens

<400> 3868
ugggaacggg uuccggcaga cgcug                                             25


<210> 3869
<211> 25
<212> RNA
<213> Homo sapiens

<400> 3869
cagcgucugc cggaacccgu uccca                                             25


<210> 3870
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3870
uuaggccgca gaucugggug a                                                 21


<210> 3871
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3871
ucacccagau cugcggccua a                                                 21


<210> 3872
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3872
aauaggccac ggaucugggc aa                                                22


<210> 3873
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3873
uugcccagau ccguggccua uu                                                22


<210> 3874
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3874
cacccagauc ugcggccuaa u                                                 21


<210> 3875
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3875
auuaggccgc agaucugggu g                                                 21


<210> 3876
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3876
uuagggcccu ggcuccaucu cc                                                22


<210> 3877
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3877
ggagauggag ccagggcccu aa                                                22


<210> 3878
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3878
uucauucggc uguccagaug ua                                                22


<210> 3879
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3879
uacaucugga cagccgaaug aa                                                22


<210> 3880
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3880
uugcagcugc cugggaguga cuuc                                              24


<210> 3881
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3881
gaagucacuc ccaggcagcu gcaa                                              24


<210> 3882
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3882
uugggacaua cuuaugcuaa a                                                 21


<210> 3883
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3883
uuuagcauaa guauguccca a                                                 21


<210> 3884
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3884
ucucacugua gccucgaacc cc                                                22


<210> 3885
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3885
gggguucgag gcuacaguga ga                                                22


<210> 3886
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3886
uuugaggcua cagugagaug ug                                                22


<210> 3887
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3887
cacaucucac uguagccuca aa                                                22


<210> 3888
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3888
cagggaggug aaugugau                                                     18


<210> 3889
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3889
aucacauuca ccucccug                                                     18


<210> 3890
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3890
gaugaugcug cugaugcug                                                    19


<210> 3891
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3891
cagcaucagc agcaucauc                                                    19


<210> 3892
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3892
ccagacagaa uucuaugcac uuuc                                              24


<210> 3893
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3893
gaaagugcau agaauucugu cugg                                              24


<210> 3894
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3894
cuccuggggc ccgcacucuc gc                                                22


<210> 3895
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3895
gcgagagugc gggccccagg ag                                                22


<210> 3896
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3896
cuccguuugc cuguuucgcu g                                                 21


<210> 3897
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3897
cagcgaaaca ggcaaacgga g                                                 21


<210> 3898
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3898
cucggcgcgg ggcgcgggcu cc                                                22


<210> 3899
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3899
ggagcccgcg ccccgcgccg ag                                                22


<210> 3900
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3900
gcccuccgcc cgugcacccc g                                                 21


<210> 3901
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3901
cggggugcac gggcggaggg c                                                 21


<210> 3902
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3902
gcccgcgugu ggagccaggu gu                                                22


<210> 3903
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3903
acaccuggcu ccacacgcgg gc                                                22


<210> 3904
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3904
aaaaccgucu aguuacaguu gu                                                22


<210> 3905
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3905
acaacuguaa cuagacgguu uu                                                22


<210> 3906
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3906
uccagugccc uccucucc                                                     18


<210> 3907
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3907
ggagaggagg gcacugga                                                     18


<210> 3908
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3908
ugaggcagua gauugaau                                                     18


<210> 3909
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3909
auucaaucua cugccuca                                                     18


<210> 3910
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3910
aggggcuggc uuuccucugg uc                                                22


<210> 3911
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3911
gaccagagga aagccagccc cu                                                22


<210> 3912
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3912
uggagagaaa ggcaguuccu ga                                                22


<210> 3913
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3913
ucaggaacug ccuuucucuc ca                                                22


<210> 3914
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3914
ucgugucuug uguugcagcc gg                                                22


<210> 3915
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3915
ccggcugcaa cacaagacac ga                                                22


<210> 3916
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3916
ggcuacaaca caggacccgg gc                                                22


<210> 3917
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3917
gcccgggucc uguguuguag cc                                                22


<210> 3918
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3918
cggcggggac ggcgauuggu c                                                 21


<210> 3919
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3919
gaccaaucgc cguccccgcc g                                                 21


<210> 3920
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3920
cgcaggggcc gggugcucac cg                                                22


<210> 3921
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3921
cggugagcac ccggccccug cg                                                22


<210> 3922
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3922
ugagugccgg ugccugcccu g                                                 21


<210> 3923
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3923
cagggcaggc accggcacuc a                                                 21


<210> 3924
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3924
gcugcgcuug gauuucgucc cc                                                22


<210> 3925
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3925
ggggacgaaa uccaagcgca gc                                                22


<210> 3926
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3926
caacggaauc ccaaaagcag cug                                               23


<210> 3927
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3927
cagcugcuuu ugggauuccg uug                                               23


<210> 3928
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3928
ucaggccagg cacaguggcu ca                                                22


<210> 3929
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3929
ugagccacug ugccuggccu ga                                                22


<210> 3930
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3930
accgugcaaa gguagcaua                                                    19


<210> 3931
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3931
uaugcuaccu uugcacggu                                                    19


<210> 3932
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3932
ccuccugccc uccuugcugu                                                   20


<210> 3933
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3933
acagcaagga gggcaggagg                                                   20


<210> 3934
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3934
uguuuugaua acaguaaugu                                                   20


<210> 3935
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3935
acauuacugu uaucaaaaca                                                   20


<210> 3936
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3936
guguuaauua aaccucuauu uac                                               23


<210> 3937
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3937
guaaauagag guuuaauuaa cac                                               23


<210> 3938
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3938
cuguaauaua aauuuaauuu auu                                               23


<210> 3939
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3939
aauaaauuaa auuuauauua cag                                               23


<210> 3940
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3940
uuggggaaac ggccgcugag ug                                                22


<210> 3941
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3941
cacucagcgg ccguuucccc aa                                                22


<210> 3942
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3942
ccucccaugc caagaacucc c                                                 21


<210> 3943
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3943
gggaguucuu ggcaugggag g                                                 21


<210> 3944
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3944
gguucuuagc auaggagguc u                                                 21


<210> 3945
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3945
agaccuccua ugcuaagaac c                                                 21


<210> 3946
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3946
uguucucuuu gccaaggaca g                                                 21


<210> 3947
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3947
cuguccuugg caaagagaac a                                                 21


<210> 3948
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3948
aaaucucugc aggcaaaugu ga                                                22


<210> 3949
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3949
ucacauuugc cugcagagau uu                                                22


<210> 3950
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3950
caugguucug ucaagcaccg cg                                                22


<210> 3951
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3951
cgcggugcuu gacagaacca ug                                                22


<210> 3952
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3952
uugugcuuga ucuaaccaug u                                                 21


<210> 3953
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3953
acaugguuag aucaagcaca a                                                 21


<210> 3954
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3954
ucugcaagug ucagaggcga gg                                                22


<210> 3955
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3955
ccucgccucu gacacuugca ga                                                22


<210> 3956
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3956
gagagcagug uguguugccu gg                                                22


<210> 3957
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3957
ccaggcaaca cacacugcuc uc                                                22


<210> 3958
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3958
aucacauugc cagugauuac cc                                                22


<210> 3959
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3959
ggguaaucac uggcaaugug au                                                22


<210> 3960
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3960
agcagaggca gagaggcuca gg                                                22


<210> 3961
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3961
ccugagccuc ucugccucug cu                                                22


<210> 3962
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3962
ugaggcucug uuagccuugg cuc                                               23


<210> 3963
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3963
gagccaaggc uaacagagcc uca                                               23


<210> 3964
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3964
uaucauggag uugguaaagc ac                                                22


<210> 3965
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3965
gugcuuuacc aacuccauga ua                                                22


<210> 3966
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3966
guuuuaccac cuccaggaga cu                                                22


<210> 3967
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3967
agucuccugg aggugguaaa ac                                                22


<210> 3968
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3968
cgccucuuca gcgcugucuu cc                                                22


<210> 3969
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3969
ggaagacagc gcugaagagg cg                                                22


<210> 3970
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3970
caggcaguga cuguucagac guc                                               23


<210> 3971
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3971
gacgucugaa cagucacugc cug                                               23


<210> 3972
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3972
agaauugcgu uuggacaauc agu                                               23


<210> 3973
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3973
acugauuguc caaacgcaau ucu                                               23


<210> 3974
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3974
agauguccag ccacaauucu cg                                                22


<210> 3975
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3975
cgagaauugu ggcuggacau cu                                                22


<210> 3976
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3976
agcagaagca gggagguucu ccca                                              24


<210> 3977
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3977
ugggagaacc ucccugcuuc ugcu                                              24


<210> 3978
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3978
uaugugggau gguaaaccgc uu                                                22


<210> 3979
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3979
aagcgguuua ccaucccaca ua                                                22


<210> 3980
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3980
ugguuuaccg ucccacauac au                                                22


<210> 3981
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3981
auguaugugg gacgguaaac ca                                                22


<210> 3982
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3982
cagugcaaug auauugucaa agc                                               23


<210> 3983
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3983
gcuuugacaa uaucauugca cug                                               23


<210> 3984
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3984
uaauugcuuc cauguuu                                                      17


<210> 3985
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3985
aaacauggaa gcaauua                                                      17


<210> 3986
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3986
uugccacacu gcaacaccuu aca                                               23


<210> 3987
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3987
uguaaggugu ugcagugugg caa                                               23


<210> 3988
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3988
ucuggcuguu guggugugca a                                                 21


<210> 3989
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3989
uugcacacca caacagccag a                                                 21


<210> 3990
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3990
gauaucagcu caguaggcac cg                                                22


<210> 3991
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3991
cggugccuac ugagcugaua uc                                                22


<210> 3992
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3992
guuccugcug aacugagcca g                                                 21


<210> 3993
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3993
cuggcucagu ucagcaggaa c                                                 21


<210> 3994
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3994
auauggguuu acuaguuggu                                                   20


<210> 3995
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3995
accaacuagu aaacccauau                                                   20


<210> 3996
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3996
ugcuaugcca acauauugcc au                                                22


<210> 3997
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3997
auggcaauau guuggcauag ca                                                22


<210> 3998
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3998
aggcaagaug cuggcauagc u                                                 21


<210> 3999
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3999
agcuaugcca gcaucuugcc u                                                 21


<210> 4000
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4000
cggggcggca ggggccuc                                                     18


<210> 4001
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4001
gaggccccug ccgccccg                                                     18


<210> 4002
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4002
aaaagcuggg uugagagga                                                    19


<210> 4003
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4003
uccucucaac ccagcuuuu                                                    19


<210> 4004
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4004
cccaauacac ggucgaccuc uu                                                22


<210> 4005
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4005
aagaggucga ccguguauug gg                                                22


<210> 4006
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4006
agguuguccg uggugaguuc gca                                               23


<210> 4007
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4007
ugcgaacuca ccacggacaa ccu                                               23


<210> 4008
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4008
gcaaagcaca cggccugcag aga                                               23


<210> 4009
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4009
ucucugcagg ccgugugcuu ugc                                               23


<210> 4010
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4010
ucucugggcc ugugucuuag gc                                                22


<210> 4011
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4011
gccuaagaca caggcccaga ga                                                22


<210> 4012
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4012
gccccugggc cuauccuaga a                                                 21


<210> 4013
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4013
uucuaggaua ggcccagggg c                                                 21


<210> 4014
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4014
uccgucucag uuacuuuaua gc                                                22


<210> 4015
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4015
gcuauaaagu aacugagacg ga                                                22


<210> 4016
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4016
aacacaccua uucaaggauu ca                                                22


<210> 4017
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4017
ugaauccuug aauaggugug uu                                                22


<210> 4018
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4018
aauccuugga accuaggugu gagu                                              24


<210> 4019
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4019
acucacaccu agguuccaag gauu                                              24


<210> 4020
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4020
uaaugccccu aaaaauccuu au                                                22


<210> 4021
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4021
auaaggauuu uuaggggcau ua                                                22


<210> 4022
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4022
agggacuuuu gggggcagau gug                                               23


<210> 4023
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4023
cacaucugcc cccaaaaguc ccu                                               23


<210> 4024
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4024
uaaugccccu aaaaauccuu au                                                22


<210> 4025
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4025
auaaggauuu uuaggggcau ua                                                22


<210> 4026
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4026
agggacuuuc aggggcagcu gu                                                22


<210> 4027
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4027
acagcugccc cugaaagucc cu                                                22


<210> 4028
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4028
gaaaaugaug aguagugacu gaug                                              24


<210> 4029
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4029
caucagucac uacucaucau uuuc                                              24


<210> 4030
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4030
ugagcaccac acaggccggg cgc                                               23


<210> 4031
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4031
gcgcccggcc uguguggugc uca                                               23


<210> 4032
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4032
gcuggucugc guggugcucg g                                                 21


<210> 4033
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4033
ccgagcacca cgcagaccag c                                                 21


<210> 4034
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4034
gccugcuggg guggaaccug gu                                                22


<210> 4035
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4035
accagguucc accccagcag gc                                                22


<210> 4036
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4036
gaagugcuuc gauuuugggg ugu                                               23


<210> 4037
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4037
acaccccaaa aucgaagcac uuc                                               23


<210> 4038
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4038
acucaaaaug ggggcgcuuu cc                                                22


<210> 4039
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4039
ggaaagcgcc cccauuuuga gu                                                22


<210> 4040
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4040
uauguaacau gguccacuaa cu                                                22


<210> 4041
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4041
aguuagugga ccauguuaca ua                                                22


<210> 4042
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4042
ugguagacua uggaacguag g                                                 21


<210> 4043
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4043
ccuacguucc auagucuacc a                                                 21


<210> 4044
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4044
uguagauacg agcaccagcc ac                                                22


<210> 4045
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4045
guggcuggug cucguaucua ca                                                22


<210> 4046
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4046
acaggcggcu guagcaaugg ggg                                               23


<210> 4047
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4047
cccccauugc uacagccgcc ugu                                               23


<210> 4048
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4048
aauucccuug uagauaaccc gg                                                22


<210> 4049
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4049
ccggguuauc uacaagggaa uu                                                22


<210> 4050
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4050
uacgcgcaga ccacaggaug uc                                                22


<210> 4051
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4051
gacauccugu ggucugcgcg ua                                                22


<210> 4052
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4052
uuacacacaa cugaggauca ua                                                22


<210> 4053
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4053
uaugauccuc aguugugugu aa                                                22


<210> 4054
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4054
uagcccccag gcuucacuug gcg                                               23


<210> 4055
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4055
cgccaaguga agccuggggg cua                                               23


<210> 4056
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4056
agggcauagg agaggguuga uau                                               23


<210> 4057
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4057
auaucaaccc ucuccuaugc ccu                                               23


<210> 4058
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4058
gaauguugcu cggugaaccc cu                                                22


<210> 4059
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4059
agggguucac cgagcaacau uc                                                22


<210> 4060
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4060
agguuacccg agcaacuuug cau                                               23


<210> 4061
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4061
augcaaaguu gcucggguaa ccu                                               23


<210> 4062
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4062
uauguaacac gguccacuaa cc                                                22


<210> 4063
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4063
gguuagugga ccguguuaca ua                                                22


<210> 4064
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4064
uaguagaccg uauagcguac g                                                 21


<210> 4065
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4065
cguacgcuau acggucuacu a                                                 21


<210> 4066
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4066
acuucaccug guccacuagc cgu                                               23


<210> 4067
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4067
acggcuagug gaccagguga agu                                               23


<210> 4068
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4068
guguucucug auggacag                                                     18


<210> 4069
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4069
cuguccauca gagaacac                                                     18


<210> 4070
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4070
caggucgucu ugcagggcuu cu                                                22


<210> 4071
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4071
agaagcccug caagacgacc ug                                                22


<210> 4072
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4072
ugucuugcag gccgucaugc a                                                 21


<210> 4073
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4073
ugcaugacgg ccugcaagac a                                                 21


<210> 4074
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4074
aucaugaugg gcuccucggu gu                                                22


<210> 4075
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4075
acaccgagga gcccaucaug au                                                22


<210> 4076
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4076
uugcuaguug cacuccucuc ugu                                               23


<210> 4077
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4077
acagagagga gugcaacuag caa                                               23


<210> 4078
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4078
uaggcagugu auugcuagcg gcugu                                             25


<210> 4079
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4079
acagccgcua gcaauacacu gccua                                             25


<210> 4080
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4080
auuggggaca uuuugcauuc au                                                22


<210> 4081
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4081
augaaugcaa aaugucccca au                                                22


<210> 4082
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4082
uuuugcgaug uguuccuaau au                                                22


<210> 4083
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4083
auauuaggaa cacaucgcaa aa                                                22


<210> 4084
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4084
uugggaucau uuugcaucca ua                                                22


<210> 4085
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4085
uauggaugca aaaugauccc aa                                                22


<210> 4086
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4086
uuuugcaaua uguuccugaa ua                                                22


<210> 4087
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4087
uauucaggaa cauauugcaa aa                                                22


<210> 4088
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4088
gcaguccaug ggcauauaca c                                                 21


<210> 4089
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4089
guguauaugc ccauggacug c                                                 21


<210> 4090
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4090
uaugugccuu uggacuacau cg                                                22


<210> 4091
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4091
cgauguaguc caaaggcaca ua                                                22


<210> 4092
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4092
auacacauac acgcaacaca cau                                               23


<210> 4093
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4093
auguguguug cguguaugug uau                                               23


<210> 4094
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4094
uugcauguca gauuguaauu ccc                                               23


<210> 4095
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4095
gggaauuaca aucugacaug caa                                               23


<210> 4096
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4096
ucacuccucu ccucccgucu u                                                 21


<210> 4097
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4097
aagacgggag gagaggagug a                                                 21


<210> 4098
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4098
ucaggcucag uccccucccg au                                                22


<210> 4099
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4099
aucgggaggg gacugagccu ga                                                22


<210> 4100
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4100
gucauacacg gcucuccucu cu                                                22


<210> 4101
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4101
agagaggaga gccguguaug ac                                                22


<210> 4102
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4102
agaggcuggc cgugaugaau uc                                                22


<210> 4103
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4103
gaauucauca cggccagccu cu                                                22


<210> 4104
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4104
aaucauacag ggacauccag uu                                                22


<210> 4105
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4105
aacuggaugu cccuguauga uu                                                22


<210> 4106
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4106
aaucguacag ggucauccac uu                                                22


<210> 4107
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4107
aaguggauga cccuguacga uu                                                22


<210> 4108
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4108
uugaaaggcu auuucuuggu c                                                 21


<210> 4109
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4109
gaccaagaaa uagccuuuca a                                                 21


<210> 4110
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4110
cccagauaau ggcacucuca a                                                 21


<210> 4111
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4111
uugagagugc cauuaucugg g                                                 21


<210> 4112
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4112
caaccuggag gacuccaugc ug                                                22


<210> 4113
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4113
cagcauggag uccuccaggu ug                                                22


<210> 4114
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4114
ccauggaucu ccaggugggu                                                   20


<210> 4115
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4115
acccaccugg agauccaugg                                                   20


<210> 4116
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4116
cuuaugcaag auucccuucu ac                                                22


<210> 4117
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4117
guagaaggga aucuugcaua ag                                                22


<210> 4118
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4118
aguggggaac ccuuccauga gg                                                22


<210> 4119
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4119
ccucauggaa ggguucccca cu                                                22


<210> 4120
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4120
aggaccugcg ggacaagauu cuu                                               23


<210> 4121
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4121
aagaaucuug ucccgcaggu ccu                                               23


<210> 4122
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4122
caaaccacac ugugguguua ga                                                22


<210> 4123
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4123
ucuaacacca cagugugguu ug                                                22


<210> 4124
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4124
cagcagcaca cugugguuug u                                                 21


<210> 4125
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4125
acaaaccaca gugugcugcu g                                                 21


<210> 4126
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4126
uuucaagcca gggggcguuu uuc                                               23


<210> 4127
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4127
gaaaaacgcc cccuggcuug aaa                                               23


<210> 4128
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4128
ucacuaccug acaauacagu                                                   20


<210> 4129
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4129
acuguauugu cagguaguga                                                   20


<210> 4130
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4130
ugcuguauug ucagguagug a                                                 21


<210> 4131
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4131
ucacuaccug acaauacagc a                                                 21


<210> 4132
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4132
uucugccucu guccaggucc uu                                                22


<210> 4133
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4133
aaggaccugg acagaggcag aa                                                22


<210> 4134
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4134
agggcuggac ucagcggcgg agcu                                              24


<210> 4135
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4135
agcuccgccg cugaguccag cccu                                              24


<210> 4136
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4136
ugacugccuc acugaccacu u                                                 21


<210> 4137
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4137
aaguggucag ugaggcaguc a                                                 21


<210> 4138
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4138
aauuugguuu cugaggcacu uagu                                              24


<210> 4139
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4139
acuaagugcc ucagaaacca aauu                                              24


<210> 4140
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4140
uacuuuucua gguuguuggg g                                                 21


<210> 4141
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4141
ccccaacaac cuagaaaagu a                                                 21


<210> 4142
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4142
ucacaacaac cuugcagggu aga                                               23


<210> 4143
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4143
ucuacccugc aagguuguug uga                                               23


<210> 4144
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4144
cuuggauuuu ccugggccuc ag                                                22


<210> 4145
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4145
cugaggccca ggaaaaucca ag                                                22


<210> 4146
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4146
ugaggacagg gcaaauucac ga                                                22


<210> 4147
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4147
ucgugaauuu gcccuguccu ca                                                22


<210> 4148
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4148
aucauaugaa ccaaacucua au                                                22


<210> 4149
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4149
auuagaguuu gguucauaug au                                                22


<210> 4150
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4150
uagagucugg cugauauggu uu                                                22


<210> 4151
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4151
aaaccauauc agccagacuc ua                                                22


<210> 4152
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4152
ccugugcucc cagggccucg c                                                 21


<210> 4153
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4153
gcgaggcccu gggagcacag g                                                 21


<210> 4154
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4154
ugaggcccuu ggggcacagu gg                                                22


<210> 4155
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4155
ccacugugcc ccaagggccu ca                                                22


<210> 4156
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4156
uccuaaaucu gaaaguccaa aa                                                22


<210> 4157
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4157
uuuuggacuu ucagauuuag ga                                                22


<210> 4158
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4158
uuggacuuuu ucagauuugg ggau                                              24


<210> 4159
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4159
auccccaaau cugaaaaagu ccaa                                              24


<210> 4160
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4160
augcaccugg gcaaggauuc ug                                                22


<210> 4161
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4161
cagaauccuu gcccaggugc au                                                22


<210> 4162
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4162
uaauccuugc uaccugggug aga                                               23


<210> 4163
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4163
ucucacccag guagcaagga uua                                               23


<210> 4164
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4164
uuuugugucu cccauucccc ag                                                22


<210> 4165
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4165
cuggggaaug ggagacacaa aa                                                22


<210> 4166
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4166
agggggaugg cagagcaaaa uu                                                22


<210> 4167
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4167
aauuuugcuc ugccaucccc cu                                                22


<210> 4168
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4168
gugcauggcu guauauauaa ca                                                22


<210> 4169
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4169
uguuauauau acagccaugc ac                                                22


<210> 4170
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4170
uauauauaca gccaugcacu c                                                 21


<210> 4171
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4171
gagugcaugg cuguauauau a                                                 21


<210> 4172
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4172
aaugcacccg ggcaaggauu cu                                                22


<210> 4173
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4173
agaauccuug cccgggugca uu                                                22


<210> 4174
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4174
aauccuuugu cccuggguga ga                                                22


<210> 4175
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4175
ucucacccag ggacaaagga uu                                                22


<210> 4176
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4176
aaugcaccug ggcaaggauu ca                                                22


<210> 4177
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4177
ugaauccuug cccaggugca uu                                                22


<210> 4178
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4178
auccuugcua ucugggugcu a                                                 21


<210> 4179
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4179
uagcacccag auagcaagga u                                                 21


<210> 4180
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4180
agacccuggu cugcacucua uc                                                22


<210> 4181
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4181
gauagagugc agaccagggu cu                                                22


<210> 4182
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4182
uugcagcugc gguuguaagg u                                                 21


<210> 4183
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4183
accuuacaac cgcagcugca a                                                 21


<210> 4184
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4184
cgucaacacu ugcugguuuc cu                                                22


<210> 4185
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4185
aggaaaccag caaguguuga cg                                                22


<210> 4186
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4186
gggagccagg aaguauugau gu                                                22


<210> 4187
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4187
acaucaauac uuccuggcuc cc                                                22


<210> 4188
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4188
uaaggcaccc uucugaguag a                                                 21


<210> 4189
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4189
ucuacucaga agggugccuu a                                                 21


<210> 4190
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4190
uauucaggaa gguguuacuu aa                                                22


<210> 4191
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4191
uuaaguaaca ccuuccugaa ua                                                22


<210> 4192
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4192
uuuugcaccu uuuggaguga a                                                 21


<210> 4193
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4193
uucacuccaa aaggugcaaa a                                                 21


<210> 4194
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4194
ugauuguagc cuuuuggagu aga                                               23


<210> 4195
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4195
ucuacuccaa aaggcuacaa uca                                               23


<210> 4196
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4196
ggguuuguag cuuugcuggc aug                                               23


<210> 4197
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4197
caugccagca aagcuacaaa ccc                                               23


<210> 4198
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4198
cagggcucag ggauuggaug gag                                               23


<210> 4199
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4199
cuccauccaa ucccugagcc cug                                               23


<210> 4200
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4200
augcuacucg gaaaucccac uga                                               23


<210> 4201
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4201
ucagugggau uuccgaguag cau                                               23


<210> 4202
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4202
gugggauuuc ugaguagcau c                                                 21


<210> 4203
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4203
gaugcuacuc agaaauccca c                                                 21


<210> 4204
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4204
ccggggcaga uugguguagg gug                                               23


<210> 4205
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4205
cacccuacac caaucugccc cgg                                               23


<210> 4206
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4206
acggagacga caagacugug cug                                               23


<210> 4207
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4207
cagcacaguc uugucgucuc cgu                                               23


<210> 4208
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4208
aauccacgcu gagcuuggca uc                                                22


<210> 4209
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4209
gaugccaagc ucagcgugga uu                                                22


<210> 4210
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4210
aggaaaugag gcuggcuagg agc                                               23


<210> 4211
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4211
gcuccuagcc agccucauuu ccu                                               23


<210> 4212
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4212
ugauugguac gucugugggu ag                                                22


<210> 4213
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4213
cuacccacag acguaccaau ca                                                22


<210> 4214
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4214
aaucagugaa ugccuugaac cu                                                22


<210> 4215
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4215
agguucaagg cauucacuga uu                                                22


<210> 4216
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4216
uuacaggcgu gaaccaccgc g                                                 21


<210> 4217
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4217
cgcggugguu cacgccugua a                                                 21


<210> 4218
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4218
uacugcagac aguggcaauc a                                                 21


<210> 4219
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4219
ugauugccac ugucugcagu a                                                 21


<210> 4220
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4220
guuucaccau guuggucagg c                                                 21


<210> 4221
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4221
gccugaccaa cauggugaaa c                                                 21


<210> 4222
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4222
uaaauuucac cuuucugaga agg                                               23


<210> 4223
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4223
ccuucucaga aaggugaaau uua                                               23


<210> 4224
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4224
uucacaagga ggugucauuu au                                                22


<210> 4225
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4225
auaaaugaca ccuccuugug aa                                                22


<210> 4226
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4226
uaaauuucac cuuucugaga aga                                               23


<210> 4227
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4227
ucuucucaga aaggugaaau uua                                               23


<210> 4228
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4228
uucucaagga ggugucguuu au                                                22


<210> 4229
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4229
auaaacgaca ccuccuugag aa                                                22


<210> 4230
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4230
auugacacuu cugugaguag a                                                 21


<210> 4231
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4231
ucuacucaca gaagugucaa u                                                 21


<210> 4232
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4232
uacucuggag agugacaauc aug                                               23


<210> 4233
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4233
caugauuguc acucuccaga gua                                               23


<210> 4234
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4234
auugacaccu cugugagugg a                                                 21


<210> 4235
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4235
uccacucaca gaggugucaa u                                                 21


<210> 4236
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4236
uucucaagag ggaggcaauc au                                                22


<210> 4237
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4237
augauugccu cccucuugag aa                                                22


<210> 4238
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4238
gagugccuuc uuuuggagcg uu                                                22


<210> 4239
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4239
aacgcuccaa aagaaggcac uc                                                22


<210> 4240
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4240
ugcuuccuuu cagagggu                                                     18


<210> 4241
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4241
acccucugaa aggaagca                                                     18


<210> 4242
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4242
aucuggaggu aagaagcacu uu                                                22


<210> 4243
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4243
aaagugcuuc uuaccuccag au                                                22


<210> 4244
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4244
gaaagcgcuu cccuuugcug ga                                                22


<210> 4245
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4245
uccagcaaag ggaagcgcuu uc                                                22


<210> 4246
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4246
cugcaaaggg aagcccuuuc                                                   20


<210> 4247
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4247
gaaagggcuu cccuuugcag                                                   20


<210> 4248
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4248
caaagcgcuu cccuuuggag c                                                 21


<210> 4249
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4249
gcuccaaagg gaagcgcuuu g                                                 21


<210> 4250
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4250
cucuagaggg aagcacuuuc ug                                                22


<210> 4251
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4251
cagaaagugc uucccucuag ag                                                22


<210> 4252
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4252
aaagcgcuuc ccuucagagu g                                                 21


<210> 4253
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4253
cacucugaag ggaagcgcuu u                                                 21


<210> 4254
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4254
cucuagaggg aagcgcuuuc ug                                                22


<210> 4255
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4255
cagaaagcgc uucccucuag ag                                                22


<210> 4256
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4256
aaagugcauc cuuuuagagg uu                                                22


<210> 4257
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4257
aaccucuaaa aggaugcacu uu                                                22


<210> 4258
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4258
cucuagaggg aagcgcuuuc ug                                                22


<210> 4259
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4259
cagaaagcgc uucccucuag ag                                                22


<210> 4260
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4260
aaagugcauc uuuuuagagg au                                                22


<210> 4261
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4261
auccucuaaa aagaugcacu uu                                                22


<210> 4262
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4262
cucuagaggg aagcgcuuuc ug                                                22


<210> 4263
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4263
cagaaagcgc uucccucuag ag                                                22


<210> 4264
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4264
aaagugcuuc cuuuuagagg g                                                 21


<210> 4265
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4265
cccucuaaaa ggaagcacuu u                                                 21


<210> 4266
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4266
aaagugcuuc cuuuuagagg gu                                                22


<210> 4267
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4267
acccucuaaa aggaagcacu uu                                                22


<210> 4268
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4268
cucuagaggg aagcacuuuc ug                                                22


<210> 4269
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4269
cagaaagugc uucccucuag ag                                                22


<210> 4270
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4270
aaagugcuuc ucuuuggugg gu                                                22


<210> 4271
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4271
acccaccaaa gagaagcacu uu                                                22


<210> 4272
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4272
cuacaaaggg aagcccuuuc                                                   20


<210> 4273
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4273
gaaagggcuu cccuuuguag                                                   20


<210> 4274
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4274
aaagugcuuc cuuuuugagg g                                                 21


<210> 4275
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4275
cccucaaaaa ggaagcacuu u                                                 21


<210> 4276
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4276
aagugcuucc uuuuagaggg uu                                                22


<210> 4277
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4277
aacccucuaa aaggaagcac uu                                                22


<210> 4278
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4278
acaaagugcu ucccuuuaga gugu                                              24


<210> 4279
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4279
acacucuaaa gggaagcacu uugu                                              24


<210> 4280
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4280
aacgcacuuc ccuuuagagu gu                                                22


<210> 4281
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4281
acacucuaaa gggaagugcg uu                                                22


<210> 4282
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4282
aaaaugguuc ccuuuagagu gu                                                22


<210> 4283
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4283
acacucuaaa gggaaccauu uu                                                22


<210> 4284
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4284
cucuagaggg aagcgcuuuc ug                                                22


<210> 4285
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4285
cagaaagcgc uucccucuag ag                                                22


<210> 4286
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4286
gaacgcgcuu cccuauagag ggu                                               23


<210> 4287
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4287
acccucuaua gggaagcgcg uuc                                               23


<210> 4288
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4288
cucuagaggg aagcgcuuuc ug                                                22


<210> 4289
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4289
cagaaagcgc uucccucuag ag                                                22


<210> 4290
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4290
gaaggcgcuu cccuuuggag u                                                 21


<210> 4291
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4291
acuccaaagg gaagcgccuu c                                                 21


<210> 4292
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4292
cugcaaaggg aagcccuuuc                                                   20


<210> 4293
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4293
gaaagggcuu cccuuugcag                                                   20


<210> 4294
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4294
ccucccacac ccaaggcuug ca                                                22


<210> 4295
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4295
ugcaagccuu ggguguggga gg                                                22


<210> 4296
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4296
caugccuuga guguaggacc gu                                                22


<210> 4297
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4297
acgguccuac acucaaggca ug                                                22


<210> 4298
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4298
aucauacaag gacaauuucu uu                                                22


<210> 4299
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4299
aaagaaauug uccuuguaug au                                                22


<210> 4300
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4300
ggagaaauua uccuuggugu gu                                                22


<210> 4301
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4301
acacaccaag gauaauuucu cc                                                22


<210> 4302
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4302
uggugggcac agaaucugga cu                                                22


<210> 4303
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4303
aguccagauu cugugcccac ca                                                22


<210> 4304
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4304
aaaggauucu gcugucgguc ccacu                                             25


<210> 4305
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4305
agugggaccg acagcagaau ccuuu                                             25


<210> 4306
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4306
ucggggauca ucaugucacg aga                                               23


<210> 4307
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4307
ucucgugaca ugaugauccc cga                                               23


<210> 4308
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4308
aaacauucgc ggugcacuuc uu                                                22


<210> 4309
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4309
aagaagugca ccgcgaaugu uu                                                22


<210> 4310
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4310
auucugcauu uuuagcaagu uc                                                22


<210> 4311
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4311
gaacuugcua aaaaugcaga au                                                22


<210> 4312
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4312
accugagguu gugcauuucu aa                                                22


<210> 4313
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4313
uuagaaaugc acaaccucag gu                                                22


<210> 4314
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4314
ucagcaaaca uuuauugugu gc                                                22


<210> 4315
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4315
gcacacaaua aauguuugcu ga                                                22


<210> 4316
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4316
ucaguaaaug uuuauuagau ga                                                22


<210> 4317
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4317
ucaucuaaua aacauuuacu ga                                                22


<210> 4318
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4318
agcuacaguu acuuuugcac ca                                                22


<210> 4319
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4319
uggugcaaaa guaacuguag cu                                                22


<210> 4320
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4320
uaaaaacugc aauuacuuuc                                                   20


<210> 4321
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4321
gaaaguaauu gcaguuuuua                                                   20


<210> 4322
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4322
ugcaaaagua auugcaguuu uug                                               23


<210> 4323
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4323
caaaaacugc aauuacuuuu gca                                               23


<210> 4324
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4324
aaagaccgug acuacuuuug ca                                                22


<210> 4325
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4325
ugcaaaagua gucacggucu uu                                                22


<210> 4326
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4326
agaaguaacu acgguuuuug ca                                                22


<210> 4327
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4327
ugcaaaaacc guaguuacuu cu                                                22


<210> 4328
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4328
aaaaaccaca auuacuuuu                                                    19


<210> 4329
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4329
aaaaguaauu gugguuuuu                                                    19


<210> 4330
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4330
aaaaguaauu gcggucuuu                                                    19


<210> 4331
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4331
aaagaccgca auuacuuuu                                                    19


<210> 4332
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4332
caaaaacugc aauuacuuuu gc                                                22


<210> 4333
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4333
gcaaaaguaa uugcaguuuu ug                                                22


<210> 4334
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4334
gaaaguaauu gcuguuuuug cc                                                22


<210> 4335
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4335
ggcaaaaaca gcaauuacuu uc                                                22


<210> 4336
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4336
uaaaacugca guuauuuuug c                                                 21


<210> 4337
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4337
gcaaaaauaa cugcaguuuu a                                                 21


<210> 4338
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4338
aaaaguaauu gcaguuuuug c                                                 21


<210> 4339
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4339
gcaaaaacug caauuacuuu u                                                 21


<210> 4340
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4340
uaaaacccac aauuauguuu gu                                                22


<210> 4341
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4341
acaaacauaa uuguggguuu ua                                                22


<210> 4342
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4342
aaaaguaauu gcggguuuug cc                                                22


<210> 4343
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4343
ggcaaaaccc gcaauuacuu uu                                                22


<210> 4344
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4344
caaaaccgca guaacuuuug u                                                 21


<210> 4345
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4345
acaaaaguua cugcgguuuu g                                                 21


<210> 4346
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4346
aaaaguuauu gcgguuuugg cu                                                22


<210> 4347
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4347
agccaaaacc gcaauaacuu uu                                                22


<210> 4348
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4348
uggcaguuac uuuugcacca g                                                 21


<210> 4349
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4349
cuggugcaaa aguaacugcc a                                                 21


<210> 4350
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4350
aaaaguaauu gcgguuuuug c                                                 21


<210> 4351
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4351
gcaaaaaccg caauuacuuu u                                                 21


<210> 4352
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4352
aaaacugcag uuacuuuugc                                                   20


<210> 4353
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4353
gcaaaaguaa cugcaguuuu                                                   20


<210> 4354
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4354
aaaaguacuu gcggauuu                                                     18


<210> 4355
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4355
aaauccgcaa guacuuuu                                                     18


<210> 4356
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4356
gugcaaaagu caucacgguu                                                   20


<210> 4357
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4357
aaccgugaug acuuuugcac                                                   20


<210> 4358
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4358
gcuggugcaa aaguaauggc gg                                                22


<210> 4359
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4359
ccgccauuac uuuugcacca gc                                                22


<210> 4360
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4360
aaaaguaauc acuguuuuug cc                                                22


<210> 4361
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4361
ggcaaaaaca gugauuacuu uu                                                22


<210> 4362
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4362
agugccugag ggaguaagag                                                   20


<210> 4363
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4363
cucuuacucc cucaggcacu                                                   20


<210> 4364
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4364
ugucuuacuc ccucaggcac au                                                22


<210> 4365
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4365
augugccuga gggaguaaga ca                                                22


<210> 4366
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4366
agugccugag ggaguaagag ccc                                               23


<210> 4367
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4367
gggcucuuac ucccucaggc acu                                               23


<210> 4368
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4368
gcgacccacu cuugguuucc a                                                 21


<210> 4369
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4369
uggaaaccaa gagugggucg c                                                 21


<210> 4370
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4370
uuagcuuaag gaguaccaga uc                                                22


<210> 4371
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4371
gaucugguac uccuuaagcu aa                                                22


<210> 4372
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4372
uaugguacuc cuuaagcuaa c                                                 21


<210> 4373
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4373
guuagcuuaa ggaguaccau a                                                 21


<210> 4374
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4374
ugagcugcug uaccaaaau                                                    19


<210> 4375
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4375
auuuugguac agcagcuca                                                    19


<210> 4376
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4376
cacauaugaa gugagccagc ac                                                22


<210> 4377
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4377
gugcuggcuc acuucauaug ug                                                22


<210> 4378
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4378
ugcuggcuca uuucauaugu gu                                                22


<210> 4379
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4379
acacauauga aaugagccag ca                                                22


<210> 4380
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4380
uuccaugccu ccuagaaguu cc                                                22


<210> 4381
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4381
ggaacuucua ggaggcaugg aa                                                22


<210> 4382
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4382
agccuuccag gagaaaugga ga                                                22


<210> 4383
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4383
ucuccauuuc uccuggaagg cu                                                22


<210> 4384
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4384
uaaaacuuua agugugccua gg                                                22


<210> 4385
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4385
ccuaggcaca cuuaaaguuu ua                                                22


<210> 4386
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4386
uaggcacacu uaaaguuaua gc                                                22


<210> 4387
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4387
gcuauaacuu uaagugugcc ua                                                22


<210> 4388
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4388
gaauaugggu auauuaguuu gg                                                22


<210> 4389
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4389
ccaaacuaau auacccauau uc                                                22


<210> 4390
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4390
aaacuaauau acccauauuc ug                                                22


<210> 4391
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4391
cagaauaugg guauauuagu uu                                                22


<210> 4392
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4392
uaguucuucc cuuugcccaa uu                                                22


<210> 4393
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4393
aauugggcaa agggaagaac ua                                                22


<210> 4394
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4394
cagggaaaug ggaagaacua ga                                                22


<210> 4395
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4395
ucuaguucuu cccauuuccc ug                                                22


<210> 4396
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4396
cugaauagcu gggacuacag gu                                                22


<210> 4397
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4397
accuguaguc ccagcuauuc ag                                                22


<210> 4398
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4398
ugaaguacca gcuacucgag ag                                                22


<210> 4399
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4399
cucucgagua gcugguacuu ca                                                22


<210> 4400
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4400
cagagugaca agcugguuaa ag                                                22


<210> 4401
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4401
cuuuaaccag cuugucacuc ug                                                22


<210> 4402
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4402
uauccagcuu guuacuauau gc                                                22


<210> 4403
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4403
gcauauagua acaagcugga ua                                                22


<210> 4404
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4404
gccccgggca gugugaucau c                                                 21


<210> 4405
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4405
gaugaucaca cugcccgggg c                                                 21


<210> 4406
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4406
auggucaccu ccgggacu                                                     18


<210> 4407
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4407
agucccggag gugaccau                                                     18


<210> 4408
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4408
aagucccacu aaugccagc                                                    19


<210> 4409
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4409
gcuggcauua gugggacuu                                                    19


<210> 4410
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4410
acuggcauua gugggacuuu u                                                 21


<210> 4411
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4411
aaaaguccca cuaaugccag u                                                 21


<210> 4412
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4412
ugcacauggc aaccuagcuc cca                                               23


<210> 4413
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4413
ugggagcuag guugccaugu gca                                               23


<210> 4414
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4414
ggcugggugc ucuugugcag u                                                 21


<210> 4415
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4415
acugcacaag agcacccagc c                                                 21


<210> 4416
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4416
uaaaguaaau augcaccaaa a                                                 21


<210> 4417
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4417
uuuuggugca uauuuacuuu a                                                 21


<210> 4418
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4418
aauaaaguuc auguauggca a                                                 21


<210> 4419
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4419
uugccauaca ugaacuuuau u                                                 21


<210> 4420
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4420
uugccauaca uagacuuuau u                                                 21


<210> 4421
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4421
aauaaagucu auguauggca a                                                 21


<210> 4422
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4422
auacccauag cuuagcuccc a                                                 21


<210> 4423
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4423
ugggagcuaa gcuaugggua u                                                 21


<210> 4424
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4424
ugggagcuaa gcuaugggua u                                                 21


<210> 4425
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4425
auacccauag cuuagcuccc a                                                 21


<210> 4426
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4426
caaaguuuaa gauccuugaa gu                                                22


<210> 4427
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4427
acuucaagga ucuuaaacuu ug                                                22


<210> 4428
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4428
aucaaggauc uuaaacuuug cc                                                22


<210> 4429
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4429
ggcaaaguuu aagauccuug au                                                22


<210> 4430
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4430
aaaguagcug uaccauuugc                                                   20


<210> 4431
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4431
gcaaauggua cagcuacuuu                                                   20


<210> 4432
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4432
aggcacggug ucagcaggc                                                    19


<210> 4433
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4433
gccugcugac accgugccu                                                    19


<210> 4434
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4434
gggcgccugu gaucccaac                                                    19


<210> 4435
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4435
guugggauca caggcgccc                                                    19


<210> 4436
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4436
aguauguucu uccaggacag aac                                               23


<210> 4437
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4437
guucuguccu ggaagaacau acu                                               23


<210> 4438
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4438
gagaaaugcu ggacuaaucu gc                                                22


<210> 4439
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4439
gcagauuagu ccagcauuuc uc                                                22


<210> 4440
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4440
agaaagggug gcaauaccuc uu                                                22


<210> 4441
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4441
aagagguauu gccacccuuu cu                                                22


<210> 4442
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4442
agguauugcc acccuuucua gu                                                22


<210> 4443
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4443
acuagaaagg guggcaauac cu                                                22


<210> 4444
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4444
guagcaccuu gcaggauaag gu                                                22


<210> 4445
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4445
accuuauccu gcaaggugcu ac                                                22


<210> 4446
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4446
uacagaugca gauucucuga cuuc                                              24


<210> 4447
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4447
gaagucagag aaucugcauc ugua                                              24


<210> 4448
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4448
aacucuagcc ugagcaacag                                                   20


<210> 4449
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4449
cuguugcuca ggcuagaguu                                                   20


<210> 4450
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4450
acagcccagc aguuaucacg gg                                                22


<210> 4451
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4451
cccgugauaa cugcugggcu gu                                                22


<210> 4452
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4452
uaucguaucg uauuguauug u                                                 21


<210> 4453
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4453
acaauacaau acgauacgau a                                                 21


<210> 4454
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4454
uuagaacguu uuagggucaa au                                                22


<210> 4455
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4455
auuugacccu aaaacguucu aa                                                22


<210> 4456
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4456
uaacaaacac cuguaaaaca gc                                                22


<210> 4457
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4457
gcuguuuuac agguguuugu ua                                                22


<210> 4458
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4458
agcauacacc uguaguccua ga                                                22


<210> 4459
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4459
ucuaggacua cagguguaug cu                                                22


<210> 4460
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4460
aguuaaugaa uccuggaaag u                                                 21


<210> 4461
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4461
acuuuccagg auucauuaac u                                                 21


<210> 4462
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4462
ucagcuacua ccucuauuag g                                                 21


<210> 4463
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4463
ccuaauagag guaguagcug a                                                 21


<210> 4464
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4464
uugcucugag cuccgagaaa gc                                                22


<210> 4465
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4465
gcuuucucgg agcucagagc aa                                                22


<210> 4466
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4466
caaauaauac cacagugggu gu                                                22


<210> 4467
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4467
acacccacug ugguauuauu ug                                                22


<210> 4468
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4468
aauaauauca caguaggugu                                                   20


<210> 4469
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4469
acaccuacug ugauauuauu                                                   20


<210> 4470
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4470
aauaauauca caguaggugu ac                                                22


<210> 4471
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4471
guacaccuac ugugauauua uu                                                22


<210> 4472
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4472
gcaguggcuc ugaaaugaac uc                                                22


<210> 4473
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4473
gaguucauuu cagagccacu gc                                                22


<210> 4474
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4474
cagaucaugg gacugucuca g                                                 21


<210> 4475
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4475
cugagacagu cccaugaucu g                                                 21


<210> 4476
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4476
acuccaagaa gaaucuagac ag                                                22


<210> 4477
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4477
cugucuagau ucuucuugga gu                                                22


<210> 4478
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4478
cucauuuaag uagucugaug cc                                                22


<210> 4479
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4479
ggcaucagac uacuuaaaug ag                                                22


<210> 4480
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4480
ucaaguaguu ucaugauaaa gg                                                22


<210> 4481
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4481
ccuuuaucau gaaacuacuu ga                                                22


<210> 4482
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4482
ugggggagug cagugauugu gg                                                22


<210> 4483
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4483
ccacaaucac ugcacucccc ca                                                22


<210> 4484
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4484
uccugucuuu ccuuguugga gc                                                22


<210> 4485
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4485
gcuccaacaa ggaaagacag ga                                                22


<210> 4486
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4486
uaaugcauua aauuauugaa gg                                                22


<210> 4487
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4487
ccuucaauaa uuuaaugcau ua                                                22


<210> 4488
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4488
uuauugucac guucugauu                                                    19


<210> 4489
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4489
aaucagaacg ugacaauaa                                                    19


<210> 4490
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4490
ugagucagca acauauccca ug                                                22


<210> 4491
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4491
caugggauau guugcugacu ca                                                22


<210> 4492
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4492
aggagaaguc gggaaggu                                                     18


<210> 4493
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4493
accuucccga cuucuccu                                                     18


<210> 4494
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4494
cgaaaacagc aauuaccuuu gc                                                22


<210> 4495
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4495
gcaaagguaa uugcuguuuu cg                                                22


<210> 4496
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4496
uuaggccauc aucccauuau gc                                                22


<210> 4497
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4497
gcauaauggg augauggccu aa                                                22


<210> 4498
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4498
uguuucgggg cucauggccu gug                                               23


<210> 4499
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4499
cacaggccau gagccccgaa aca                                               23


<210> 4500
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4500
aaagguaauu gcaguuuuuc cc                                                22


<210> 4501
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4501
gggaaaaacu gcaauuaccu uu                                                22


<210> 4502
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4502
uucuggauaa caugcugaag cu                                                22


<210> 4503
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4503
agcuucagca uguuauccag aa                                                22


<210> 4504
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4504
acguuugaau gcuguacaag gc                                                22


<210> 4505
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4505
gccuuguaca gcauucaaac gu                                                22


<210> 4506
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4506
augagcgacu gugccugacc                                                   20


<210> 4507
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4507
ggucaggcac agucgcucau                                                   20


<210> 4508
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4508
gagccaguug gacaggagc                                                    19


<210> 4509
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4509
gcuccugucc aacuggcuc                                                    19


<210> 4510
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4510
uucauuuggu auaaaccgcg auu                                               23


<210> 4511
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4511
aaucgcgguu uauaccaaau gaa                                               23


<210> 4512
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4512
uugagaauga ugaaucauua gg                                                22


<210> 4513
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4513
ccuaaugauu caucauucuc aa                                                22


<210> 4514
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4514
uuacaguugu ucaaccaguu acu                                               23


<210> 4515
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4515
aguaacuggu ugaacaacug uaa                                               23


<210> 4516
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4516
caaagaggaa ggucccauua c                                                 21


<210> 4517
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4517
guaaugggac cuuccucuuu g                                                 21


<210> 4518
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4518
ucaguuccag gccaaccagg cu                                                22


<210> 4519
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4519
agccugguug gccuggaacu ga                                                22


<210> 4520
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4520
uuaugguuug ccugggacug ag                                                22


<210> 4521
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4521
cucaguccca ggcaaaccau aa                                                22


<210> 4522
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4522
ugggcguauc uguaugcua                                                    19


<210> 4523
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4523
uagcauacag auacgccca                                                    19


<210> 4524
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4524
agaccauggg uucucauugu                                                   20


<210> 4525
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4525
acaaugagaa cccauggucu                                                   20


<210> 4526
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4526
uugugucaau augcgaugau gu                                                22


<210> 4527
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4527
acaucaucgc auauugacac aa                                                22


<210> 4528
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4528
ugucucugcu gggguuucu                                                    19


<210> 4529
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4529
agaaacccca gcagagaca                                                    19


<210> 4530
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4530
aggcaccagc caggcauugc ucagc                                             25


<210> 4531
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4531
gcugagcaau gccuggcugg ugccu                                             25


<210> 4532
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4532
gaagugugcc gugguguguc u                                                 21


<210> 4533
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4533
agacacacca cggcacacuu c                                                 21


<210> 4534
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4534
aagccugccc ggcuccucgg g                                                 21


<210> 4535
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4535
cccgaggagc cgggcaggcu u                                                 21


<210> 4536
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4536
guugugucag uuuaucaaac                                                   20


<210> 4537
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4537
guuugauaaa cugacacaac                                                   20


<210> 4538
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4538
uggucuagga uuguuggagg ag                                                22


<210> 4539
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4539
cuccuccaac aauccuagac ca                                                22


<210> 4540
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4540
cacacacugc aauuacuuuu gc                                                22


<210> 4541
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4541
gcaaaaguaa uugcagugug ug                                                22


<210> 4542
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4542
agggguggug uugggacagc uccgu                                             25


<210> 4543
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4543
acggagcugu cccaacacca ccccu                                             25


<210> 4544
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4544
ugagcuaaau gugugcuggg a                                                 21


<210> 4545
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4545
ucccagcaca cauuuagcuc a                                                 21


<210> 4546
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4546
gcgaggaccc cucggggucu gac                                               23


<210> 4547
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4547
gucagacccc gagggguccu cgc                                               23


<210> 4548
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4548
gcugggcagg gcuucugagc uccuu                                             25


<210> 4549
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4549
aaggagcuca gaagcccugc ccagc                                             25


<210> 4550
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4550
gggaaaagga agggggagga                                                   20


<210> 4551
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4551
uccucccccu uccuuuuccc                                                   20


<210> 4552
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4552
gcggaaggcg gagcggcgga                                                   20


<210> 4553
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4553
uccgccgcuc cgccuuccgc                                                   20


<210> 4554
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4554
gugaaggccc ggcggaga                                                     18


<210> 4555
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4555
ucuccgccgg gccuucac                                                     18


<210> 4556
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4556
ugagggagug ggugggagg                                                    19


<210> 4557
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4557
ccucccaccc acucccuca                                                    19


<210> 4558
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4558
acuggaauug gagucaaaa                                                    19


<210> 4559
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4559
uuuugacucc aauuccagu                                                    19


<210> 4560
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4560
ugagggaguu ggguguaua                                                    19


<210> 4561
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4561
uauacaccca acucccuca                                                    19


<210> 4562
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4562
ugagggagug gauuguaug                                                    19


<210> 4563
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4563
cauacaaucc acucccuca                                                    19


<210> 4564
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4564
ggcuggucag augggagug                                                    19


<210> 4565
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4565
cacucccauc ugaccagcc                                                    19


<210> 4566
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4566
agcagggcug gggauugca                                                    19


<210> 4567
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4567
ugcaaucccc agcccugcu                                                    19


<210> 4568
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4568
ugagggagga gguugggua                                                    19


<210> 4569
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4569
uacccaaccu ccucccuca                                                    19


<210> 4570
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4570
ugagguggua ggauguaga                                                    19


<210> 4571
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4571
ucuacauccu accaccuca                                                    19


<210> 4572
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4572
uccgagccug ggucucccuc uu                                                22


<210> 4573
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4573
aagagggaga cccaggcucg ga                                                22


<210> 4574
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4574
gggggucccc ggugcucgga uc                                                22


<210> 4575
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4575
gauccgagca ccggggaccc cc                                                22


<210> 4576
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4576
agucauugga ggguuugagc ag                                                22


<210> 4577
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4577
cugcucaaac ccuccaauga cu                                                22


<210> 4578
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4578
cagcaggagg ugaggggag                                                    19


<210> 4579
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4579
cuccccucac cuccugcug                                                    19


<210> 4580
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4580
acucaaaacc cuucagugac uu                                                22


<210> 4581
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4581
aagucacuga aggguuuuga gu                                                22


<210> 4582
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4582
agacuuccca uuugaaggug gc                                                22


<210> 4583
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4583
gccaccuuca aaugggaagu cu                                                22


<210> 4584
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4584
aaacucuacu uguccuucug agu                                               23


<210> 4585
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4585
acucagaagg acaaguagag uuu                                               23


<210> 4586
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4586
ggcuagcaac agcgcuuacc u                                                 21


<210> 4587
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4587
agguaagcgc uguugcuagc c                                                 21


<210> 4588
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4588
acagucugcu gagguuggag c                                                 21


<210> 4589
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4589
gcuccaaccu cagcagacug u                                                 21


<210> 4590
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4590
aucccuugca ggggcuguug ggu                                               23


<210> 4591
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4591
acccaacagc cccugcaagg gau                                               23


<210> 4592
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4592
gugagucucu aagaaaagag ga                                                22


<210> 4593
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4593
uccucuuuuc uuagagacuc ac                                                22


<210> 4594
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4594
ucuaguaaga guggcagucg a                                                 21


<210> 4595
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4595
ucgacugcca cucuuacuag a                                                 21


<210> 4596
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4596
augcugacau auuuacuaga gg                                                22


<210> 4597
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4597
ccucuaguaa auaugucagc au                                                22


<210> 4598
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4598
guucucccaa cguaagccca gc                                                22


<210> 4599
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4599
gcugggcuua cguugggaga ac                                                22


<210> 4600
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4600
uggguuuacg uugggagaac u                                                 21


<210> 4601
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4601
aguucuccca acguaaaccc a                                                 21


<210> 4602
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4602
gugucugcuu ccuguggga                                                    19


<210> 4603
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4603
ucccacagga agcagacac                                                    19


<210> 4604
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4604
cuaauaguau cuaccacaau aaa                                               23


<210> 4605
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4605
uuuauugugg uagauacuau uag                                               23


<210> 4606
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4606
ugugcuugcu cgucccgccc gca                                               23


<210> 4607
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4607
ugcgggcggg acgagcaagc aca                                               23


<210> 4608
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4608
agggaucgcg ggcggguggc ggccu                                             25


<210> 4609
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4609
aggccgccac ccgcccgcga ucccu                                             25


<210> 4610
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4610
augauccagg aaccugccuc u                                                 21


<210> 4611
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4611
agaggcaggu uccuggauca u                                                 21


<210> 4612
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4612
aguguggcuu ucuuagagc                                                    19


<210> 4613
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4613
gcucuaagaa agccacacu                                                    19


<210> 4614
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4614
ucuaggcugg uacugcuga                                                    19


<210> 4615
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4615
ucagcaguac cagccuaga                                                    19


<210> 4616
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4616
aagcagcugc cucugaggc                                                    19


<210> 4617
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4617
gccucagagg cagcugcuu                                                    19


<210> 4618
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4618
guggcugcac ucacuuccuu c                                                 21


<210> 4619
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4619
gaaggaagug agugcagcca c                                                 21


<210> 4620
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4620
aggaggcagc gcucucagga c                                                 21


<210> 4621
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4621
guccugagag cgcugccucc u                                                 21


<210> 4622
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4622
aauggcgcca cuaggguugu g                                                 21


<210> 4623
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4623
cacaacccua guggcgccau u                                                 21


<210> 4624
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4624
caacccuagg agagggugcc auuca                                             25


<210> 4625
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4625
ugaauggcac ccucuccuag gguug                                             25


<210> 4626
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4626
auaauacaug guuaaccucu uu                                                22


<210> 4627
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4627
aaagagguua accauguauu au                                                22


<210> 4628
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4628
aauauuauac agucaaccuc u                                                 21


<210> 4629
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4629
agagguugac uguauaauau u                                                 21


<210> 4630
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4630
ggcggaggga aguagguccg uuggu                                             25


<210> 4631
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4631
accaacggac cuacuucccu ccgcc                                             25


<210> 4632
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4632
ugccuggguc ucuggccugc gcgu                                              24


<210> 4633
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4633
acgcgcaggc cagagaccca ggca                                              24


<210> 4634
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4634
aggcggggcg ccgcgggacc gc                                                22


<210> 4635
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4635
gcggucccgc ggcgccccgc cu                                                22


<210> 4636
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4636
gguggcccgg ccgugccuga gg                                                22


<210> 4637
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4637
ccucaggcac ggccgggcca cc                                                22


<210> 4638
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4638
accaggaggc ugaggccccu                                                   20


<210> 4639
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4639
aggggccuca gccuccuggu                                                   20


<210> 4640
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4640
gucccugagu guauguggug                                                   20


<210> 4641
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4641
caccacauac acucagggac                                                   20


<210> 4642
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4642
uccgguucuc agggcuccac c                                                 21


<210> 4643
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4643
gguggagccc ugagaaccgg a                                                 21


<210> 4644
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4644
aggaagcccu ggaggggcug gag                                               23


<210> 4645
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4645
cuccagcccc uccagggcuu ccu                                               23


<210> 4646
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4646
cuguaugccc ucaccgcuca                                                   20


<210> 4647
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4647
ugagcgguga gggcauacag                                                   20


<210> 4648
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4648
uggugcggag agggcccaca gug                                               23


<210> 4649
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4649
cacugugggc ccucuccgca cca                                               23


<210> 4650
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4650
caacuagacu gugagcuucu ag                                                22


<210> 4651
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4651
cuagaagcuc acagucuagu ug                                                22


<210> 4652
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4652
aaggagcuua caaucuagcu ggg                                               23


<210> 4653
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4653
cccagcuaga uuguaagcuc cuu                                               23


<210> 4654
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4654
gggacccagg gagagacgua ag                                                22


<210> 4655
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4655
cuuacgucuc ucccuggguc cc                                                22


<210> 4656
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4656
gcagagugca aacaauuuug ac                                                22


<210> 4657
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4657
gucaaaauug uuugcacucu gc                                                22


<210> 4658
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4658
cggcucuggg ucugugggga                                                   20


<210> 4659
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4659
uccccacaga cccagagccg                                                   20


<210> 4660
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4660
gcagcagggu gaaacugaca ca                                                22


<210> 4661
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4661
ugugucaguu ucacccugcu gc                                                22


<210> 4662
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4662
uggaggagaa ggaaggugau g                                                 21


<210> 4663
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4663
caucaccuuc cuucuccucc a                                                 21


<210> 4664
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4664
ucugcucaua ccccaugguu ucu                                               23


<210> 4665
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4665
agaaaccaug ggguaugagc aga                                               23


<210> 4666
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4666
ugcaccaugg uugucugagc aug                                               23


<210> 4667
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4667
caugcucaga caaccauggu gca                                               23


<210> 4668
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4668
cugggaucuc cggggucuug guu                                               23


<210> 4669
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4669
aaccaagacc ccggagaucc cag                                               23


<210> 4670
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4670
ugagaccucu ggguucugag cu                                                22


<210> 4671
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4671
agcucagaac ccagaggucu ca                                                22


<210> 4672
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4672
uccaguacca cgugucaggg cca                                               23


<210> 4673
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4673
uggcccugac acgugguacu gga                                               23


<210> 4674
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4674
ggagacugau gaguucccgg ga                                                22


<210> 4675
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4675
ucccgggaac ucaucagucu cc                                                22


<210> 4676
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4676
gcaggaacuu gugagucucc u                                                 21


<210> 4677
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4677
aggagacuca caaguuccug c                                                 21


<210> 4678
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4678
cugcccuggc ccgagggacc ga                                                22


<210> 4679
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4679
ucggucccuc gggccagggc ag                                                22


<210> 4680
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4680
ccuggaaaca cugagguugu g                                                 21


<210> 4681
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4681
cacaaccuca guguuuccag g                                                 21


<210> 4682
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4682
uauaccucag uuuuaucagg ug                                                22


<210> 4683
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4683
caccugauaa aacugaggua ua                                                22


<210> 4684
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4684
uggugguuua caaaguaauu ca                                                22


<210> 4685
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4685
ugaauuacuu uguaaaccac ca                                                22


<210> 4686
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4686
uggauuucuu ugugaaucac ca                                                22


<210> 4687
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4687
uggugauuca caaagaaauc ca                                                22


<210> 4688
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4688
uccucuucuc ccuccuccca g                                                 21


<210> 4689
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4689
cugggaggag ggagaagagg a                                                 21


<210> 4690
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4690
guagaggaga uggcgcaggg                                                   20


<210> 4691
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4691
cccugcgcca ucuccucuac                                                   20


<210> 4692
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4692
gugaacgggc gccaucccga gg                                                22


<210> 4693
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4693
ccucgggaug gcgcccguuc ac                                                22


<210> 4694
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4694
gacugacacc ucuuugggug aa                                                22


<210> 4695
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4695
uucacccaaa gaggugucag uc                                                22


<210> 4696
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4696
uacucaaaaa gcugucaguc a                                                 21


<210> 4697
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4697
ugacugacag cuuuuugagu a                                                 21


<210> 4698
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4698
uuaauaucgg acaaccauug u                                                 21


<210> 4699
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4699
acaaugguug uccgauauua a                                                 21


<210> 4700
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4700
auccgcgcuc ugacucucug cc                                                22


<210> 4701
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4701
ggcagagagu cagagcgcgg au                                                22


<210> 4702
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4702
gugagucagg guggggcugg                                                   20


<210> 4703
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4703
ccagccccac ccugacucac                                                   20


<210> 4704
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4704
ugcccuuaaa ggugaaccca gu                                                22


<210> 4705
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4705
acuggguuca ccuuuaaggg ca                                                22


<210> 4706
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4706
ucuucucugu uuuggccaug ug                                                22


<210> 4707
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4707
cacauggcca aaacagagaa ga                                                22


<210> 4708
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4708
aaauuauugu acaucggaug ag                                                22


<210> 4709
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4709
cucauccgau guacaauaau uu                                                22


<210> 4710
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4710
uucaacgggu auuuauugag ca                                                22


<210> 4711
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4711
ugcucaauaa auacccguug aa                                                22


<210> 4712
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4712
cuauacaacu uacuacuuuc cc                                                22


<210> 4713
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4713
gggaaaguag uaaguuguau ag                                                22


<210> 4714
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4714
ugagguagua aguuguauug uu                                                22


<210> 4715
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4715
aacaauacaa cuuacuaccu ca                                                22


<210> 4716

<400> 4716
000


<210> 4717

<400> 4717
000


<210> 4718

<400> 4718
000


<210> 4719

<400> 4719
000


<210> 4720

<400> 4720
000


<210> 4721

<400> 4721
000


<210> 4722

<400> 4722
000


<210> 4723

<400> 4723
000


<210> 4724

<400> 4724
000


<210> 4725

<400> 4725
000


<210> 4726

<400> 4726
000


<210> 4727

<400> 4727
000


<210> 4728

<400> 4728
000


<210> 4729

<400> 4729
000


<210> 4730

<400> 4730
000


<210> 4731

<400> 4731
000


<210> 4732

<400> 4732
000


<210> 4733

<400> 4733
000


<210> 4734
<211> 3131
<212> DNA
<213> Adeno-associated virus

<400> 4734
gcggccgcga attcgccctt ggctgcgtca actggaccaa tgagaacttt cccttcaatg       60

attgcgtcga caagatggtg atctggtggg aggagggcaa gatgacggcc aaggtcgtgg      120

agtccgccaa ggccattctc ggcggcagca aggtgcgcgt ggaccaaaag tgcaagtcgt      180

ccgcccagat cgaccccacc cccgtgatcg tcacctccaa caccaacatg tgcgccgtga      240

ttgacgggaa cagcaccacc ttcgagcacc agcagcctct ccaggaccgg atgtttaagt      300

tcgaactcac ccgccgtctg gagcacgact ttggcaaggt gacaaagcag gaagtcaaag      360

agttcttccg ctgggccagt gatcacgtga ccgaggtggc gcatgagttt tacgtcagaa      420

agggcggagc cagcaaaaga cccgcccccg atgacgcgga taaaagcgag cccaagcggg      480

cctgcccctc agtcgcggat ccatcgacgt cagacgcgga aggagctccg gtggactttg      540

ccgacaggta ccaaaacaaa tgttctcgtc acgcgggcat gcttcagatg ctgtttccct      600

gcaaaacgtg cgagagaatg aatcggaatt tcaacatttg cttcacacac ggggtcagag      660

actgctcaga gtgtttcccc ggcgtgtcag aatctcaacc ggtcgtcaga aagaggacgt      720

atcggaaact ccgtgcgatt catcatctgc tggggcgggc tcccgagatt gcttgctcgg      780

cctgcgatct ggtcaacgtg gacctggatg actgtgtttc tgagcaataa atgacttaaa      840

ccaggtatgg ctgccgatgg ttatcttcca gattggctcg aggacaacct ctctgagggc      900

attcgcgagt ggtgggcgct gaaacctgga gccccgaagc ccaaagccaa ccagcaaaag      960

caggacgacg gccggggtct ggtgcttcct ggctacaagt acctcggacc cttcaacgga     1020

ctcgacaagg gggagcccgt caacgcggcg gacgcagcgg ccctcgagca cgacaaggct     1080

tacgaccagc agctgcaggc gggtgacaat ccgtacctgc ggtataacca cgccgacgcc     1140

gagtttcagg agcgtctgca agaagatacg tcttttgggg gcaacctcgg gcgagcagtc     1200

ttccaggcca agaagcgggt tctcgaacct ctcggtctgg ttgaggaagg cgctaagacg     1260

gctcctggaa agaagagacc ggtagagcca tcaccccagc gttctccaga ctcctctacg     1320

ggcatcggca agaaaggcca acagcccgcc agaaaaagac tcaattttgg tcagactggc     1380

gactcagagt cagttccaga ccctcaacct ctcggagaac ctccagcagc gccctctggt     1440

gtgggaccta atacaatggc tgcaggcggt ggcgcaccaa tggcagacaa taacgaaggc     1500

gccgacggag tgggtagttc ctcgggaaat tggcattgcg attccacatg gctgggcgac     1560

agagtcatca ccaccagcac ccgaacctgg gccctgccca cctacaacaa ccacctctac     1620

aagcaaatct ccaacgggac atcgggagga gccaccaacg acaacaccta cttcggctac     1680

agcaccccct gggggtattt tgactttaac agattccact gccacctttc accacgtgac     1740

tggcagcgac tcatcaacaa caactgggga ttccgaccca agagactcag cttcaagctc     1800

ttcaacatcc aggtcaagga ggtcacgcag aatgaaggca ccaagaccat cgccaataac     1860

ctcaccagca ccatccaggt gtttacggac tcggagtacc agctgccgta cgttctcggc     1920

tctgtccacc agggctgcct gcctccgttc ccggcggacg tgttcatgat tccccagtac     1980

ggctacctaa cactcaacaa cggtagtcag gccgtgggac gctcctcctt ctactgcctg     2040

gaatactttc cttcgcagat gctgagaacc ggcaacaact tccagtttac ttacaccttc     2100

gaggacgtgc ctttccacag cagctacgcc cacagctaga gcttggaccg gctgatgaat     2160

cctctgattg accagtacct gtactacttg tctcggactc aaacaacagg aggcacggca     2220

aatacgcaga ctctgggctt cagccaaggt gggcctaata caatggccaa tcaggcaaag     2280

aactggctgc caggaccctg ttaccgccaa caacgcgtct caacgacaac cgggcaaaac     2340

aacaatagca actttgcctg gactgctggg accaaatacc atctgaatgg aagaaattca     2400

ttggctaatc ctggcatcgc tatggcaaca cacaaagacg acgaggagcg tttttttccc     2460

agtaacggga tcctgatttt tggcaaacaa aatgctgcca gagacaatgc ggattacagc     2520

gatgtcatgc tcaccagcga ggaagaaatc aaaaccacta accctgtggc tacagaggaa     2580

tacggtatcg tggcagataa cttgcagcag caaaacacgg ctcctcaaat tggaactgtc     2640

aacagccagg gggccttacc cggtatggtc tggcagaacc gggacgtgta cctgcagggt     2700

cccatctggg ccaagattcc tcacacggac ggcaacttcc acccgtctcc gctgatgggc     2760

ggctttggcc tgaaacatcc tccgcctcag atcctgatca agaacacgcc tgtacctgcg     2820

gatcctccga ccaccttcaa ccagtcaaag ctgaactctt tcatcacgca atacagcacc     2880

ggacaggtca gcgtggaaat tgaatgggag ctgcagaagg aaaacagcaa gcgctggaac     2940

cccgagatcc agtacacctc caactactac aaatctataa gtgtggactt tgctgttaat     3000

acagaaggcg tgtactctga accccgcccc attggcaccc gttacctcac ccgtaatctg     3060

taattgcctg ttaatcaata aaccggttga ttcgtttcag ttgaactttg gtctctgcga     3120

agggcgaatt c                                                          3131


<210> 4735
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4735
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Met Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Gly Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Gly Val Phe Thr Pro 
                645                 650                 655     


Ala Leu Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4736
<211> 644
<212> PRT
<213> Adeno-associated virus


<220>
<221> MOD_RES
<222> (434)..(434)
<223> Any amino acid

<400> 4736
Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg 
1               5                   10                  15      


Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr 
            20                  25                  30          


Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg 
        35                  40                  45              


Val Leu Glu Pro Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro 
    50                  55                  60                  


Gly Lys Lys Arg Pro Val Asp Ser Pro Asp Ser Thr Ser Gly Ile Gly 
65                  70                  75                  80  


Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                85                  90                  95      


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            100                 105                 110         


Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly 
        115                 120                 125             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    130                 135                 140                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
145                 150                 155                 160 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                165                 170                 175     


Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn Val 
            180                 185                 190         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        195                 200                 205             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    210                 215                 220                 


Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln 
225                 230                 235                 240 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                245                 250                 255     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            260                 265                 270         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        275                 280                 285             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    290                 295                 300                 


Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
305                 310                 315                 320 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                325                 330                 335     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            340                 345                 350         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg 
        355                 360                 365             


Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln Phe 
    370                 375                 380                 


Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp Leu 
385                 390                 395                 400 


Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp Gln 
                405                 410                 415     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            420                 425                 430         


Asn Xaa Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His 
        435                 440                 445             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe 
    450                 455                 460                 


Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met 
465                 470                 475                 480 


Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Glu 
                485                 490                 495     


Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Ser Thr Ala Ala Gln 
            500                 505                 510         


Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        515                 520                 525             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    530                 535                 540                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
545                 550                 555                 560 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                565                 570                 575     


Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            580                 585                 590         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        595                 600                 605             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    610                 615                 620                 


Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val 
625                 630                 635                 640 


Tyr Ser Glu Pro 
                


<210> 4737
<211> 1933
<212> DNA
<213> Adeno-associated virus

<400> 4737
caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc       60

cgacgccgag tttcaggagt gtcttcaaga agatacgtct tttgggggca acctcgggcg      120

agcagtcttc caggccaaaa agcgggttct cgaacctctt ggtctggttg agacgccagc      180

taagacggca cctggaaaga agcgaccggt agactcgcca gactccacct cgggcatcgg      240

caagaaaggc cagcagcccg cgaaaaagag actcaacttt gggcagactg gcgactcaga      300

gtcagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc      360

tggtacaatg gttgcaggcg gtggcgcacc aatggctgac aataacgagg gcgccgacgg      420

agtgggtaat gcctcaggaa attggcattg cgattccaca tggctgggcg acagagtcat      480

caccaccagc acccgaacct gggccctgcc cacctacaac aaccacctct acaagcaaat      540

ctccagtcag tcagcaggga gcaccaacga taacgtctat ttcggctaca gcaccccctg      600

ggggtatttt gacttcaaca gattccattg ccacttctca ccacgtgact ggcagcgact      660

tatcaacaac aactggggat tccggcccaa gaagctcaac ttcaagctct tcaacatcca      720

ggtcaaggag gtcacgacga atgacggtgt cacaaccatc gctaataacc ttaccagcac      780

ggttcaggtc ttttcggact cggaatatca actgccgtac gtcctcggct ccgcgcacca      840

gggctgcctg cctccgttcc cggcagacgt gttcatgatt ccgcagtacg gatacctgac      900

tctgaacaat ggcagccaat cggtaggccg ttcctccttc tactgcctgg agtactttcc      960

ttctcagatg ctgagaacgg gcaacaactt cacctttagc tacaccttcg aggacgtgcc     1020

tttccacagc agctacgcgc acagccagag tctggaccgg ctgatgaatc ccctcatcga     1080

ccagtacctg tactacttgg ccagaacaca gagcaacgca ggaggtactg ctggcaatcg     1140

ggaactgcag ttttatcagg gcggacctac caccatggcc gaacaagcaa agaactggct     1200

gcccggacct tgcttccggc aacagagagt atccaagacg ctggatcaaa ataacaacag     1260

caactttgcc tggactggtg ccacaaaata ccatttaaat ggaagaaatt cattggttaa     1320

tcccggtgtc gccatggcaa cccacaagga cgacgaggaa cgcttctccc cttcgagcgg     1380

agttctaatt tttggcaaaa ctggagcagc taataaaact acattagaaa acgtgctcat     1440

gacaaatgaa gaagaaattc gtcctaccaa cccggtagct accgaggaat acgggattgt     1500

aagcagcaac ttgcaggcgg ctagcaccgc agcccagaca caagttgtta acaaccaggg     1560

agccttacct ggcatggtct ggcagaaccg ggacgtgtac ctgcaaggtc ccatttgggc     1620

caagattcct cacacggacg gcaactttca cccgtctcct ctaatgggtg gctttggact     1680

gaaacacccg cctccccaga tcctgatcaa aaacacgccg gtacctgcta atcctccaga     1740

agtgtttact cctgccaagt ttgcttcctt catcacgcag tacagcaccg ggcaagtcag     1800

cgttgagatc gagtgggagc tgcagaaaga gaacagcaag cgctggaacc cagagattca     1860

gtacacctcc aactttgaca aacagactgg agtggacttt gctgttgaca gccagggtgt     1920

ttactctgag cct                                                        1933


<210> 4738
<211> 644
<212> PRT
<213> Adeno-associated virus

<400> 4738
Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg 
1               5                   10                  15      


Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Cys Leu Gln Glu Asp Thr 
            20                  25                  30          


Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg 
        35                  40                  45              


Val Leu Glu Pro Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro 
    50                  55                  60                  


Gly Lys Lys Arg Pro Val Asp Ser Pro Asp Ser Thr Ser Gly Ile Gly 
65                  70                  75                  80  


Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                85                  90                  95      


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            100                 105                 110         


Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Val Ala Gly Gly Gly 
        115                 120                 125             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    130                 135                 140                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
145                 150                 155                 160 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                165                 170                 175     


Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn Val 
            180                 185                 190         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        195                 200                 205             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    210                 215                 220                 


Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln 
225                 230                 235                 240 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                245                 250                 255     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            260                 265                 270         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        275                 280                 285             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    290                 295                 300                 


Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
305                 310                 315                 320 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                325                 330                 335     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            340                 345                 350         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg 
        355                 360                 365             


Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln Phe 
    370                 375                 380                 


Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp Leu 
385                 390                 395                 400 


Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp Gln 
                405                 410                 415     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            420                 425                 430         


Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His 
        435                 440                 445             


Lys Asp Asp Glu Glu Arg Phe Ser Pro Ser Ser Gly Val Leu Ile Phe 
    450                 455                 460                 


Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met 
465                 470                 475                 480 


Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Glu 
                485                 490                 495     


Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Ser Thr Ala Ala Gln 
            500                 505                 510         


Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        515                 520                 525             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    530                 535                 540                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
545                 550                 555                 560 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                565                 570                 575     


Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            580                 585                 590         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        595                 600                 605             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    610                 615                 620                 


Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val 
625                 630                 635                 640 


Tyr Ser Glu Pro 
                


<210> 4739
<211> 1933
<212> DNA
<213> Adeno-associated virus

<400> 4739
caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc       60

cgacgccgag tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg      120

agcagtcttc caggccaaaa agcgggttct cgaacctctt ggtctggttg agacgccagc      180

taagacggca cctggaaaga agcgaccggt agactcgcca gactccacct cgggcatcgg      240

caagaaaggc cagcagcccg cgaaaaagag actcaacttt gggcagactg gcgactcaga      300

gccagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc      360

tggtacaatg gctgcaggcg gtggcgcacc aatggctgac aataacgagg gcgccgacgg      420

agtgggtaat gcctcaggaa attggcattg cgattccaca cggctgggcg acagagtcat      480

caccaccagc acccgaacct gggccctgcc cacctacaac aaccacctct acaagcaaat      540

ctccagtcag tcagcaggga gcaccaacga taacgtctat ttcggctaca gcaccccctg      600

ggggtatttt gacttcaaca gattccattg ccacttctca ccacgtgact ggcagcgact      660

tatcaacaac aactggggat tccggcccaa gaagctcaac ttcaagctct tcaacatcca      720

ggtcaaggag gtcacgacga atgacggcgt cacaaccatc gctaataacc ttaccagcac      780

ggttcaggtc ttttcggact cggaatatca actgccgtac gtcctcggct ccgcgcacca      840

gggctgcctg cctccgttcc cggcagacgt gttcatgatt ccgcagtacg gatacctgac      900

tctgaacaat ggcagccaat cggtaggccg ttcctccttc tactgcctgg agtactttcc      960

ttctcagatg ctgagaacgg gcaacaactt cacctttagc tacaccttcg aggacgtgcc     1020

tttccacagc agctacgcgc acagccagag tctgggccgg ctgatgaatc ccctcatcga     1080

ccagtacctg tactacttgg ccagaacaca gagcaacgca ggaggtactg ctggcaatcg     1140

ggaactgcag ttttatcagg gcggacctac caccatggcc gaacaagcaa agaactggct     1200

gcccggacct tgcttccggc aacagagagt atccaagacg ctggatcaaa ataacaacag     1260

caactttgcc tggactggtg ccacaaaata ccatttaaat ggaagaaatt cattggttaa     1320

tcccggtgtc gccatggcaa cccacaagga cgacgaggaa cgcttcttcc cttcgagcgg     1380

agttctaatt tttggcaaaa ctggagcagc taataaaact acattagaaa acgtgctcat     1440

gacaaatgaa gaagaaattc gtcctaccaa cccggtagct accgaggaat acgggattgt     1500

aagcagcaac ttgcaggcgg ctagcaccgc agcccagaca caagttgtta acaaccaggg     1560

agccttacct ggcatggtct ggcagaaccg ggacgtgtac ctgcaaggtc ccatttgggc     1620

caagattcct cacacggacg gcaactttca cccgtctcct ctaatgggtg gctttggact     1680

gaaacacccg cctccccaga tcctgatcaa aaacacaccg gtacctgcta atcctccaga     1740

agtgtttact cctgccaagt ttgcttcctt catcacgcag tacagcaccg ggcaagtcag     1800

cgttgagatc gaatgggagc tgcagaaaga gaacagcaag cgctggaacc cagagattca     1860

gtacacctcc aactttgaca aacagactgg agtggacttt gctgttgaca gccagggtgt     1920

ttactctgag cct                                                        1933


<210> 4740
<211> 644
<212> PRT
<213> Adeno-associated virus

<400> 4740
Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg 
1               5                   10                  15      


Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr 
            20                  25                  30          


Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg 
        35                  40                  45              


Val Leu Glu Pro Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro 
    50                  55                  60                  


Gly Lys Lys Arg Pro Val Asp Ser Pro Asp Ser Thr Ser Gly Ile Gly 
65                  70                  75                  80  


Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                85                  90                  95      


Gly Asp Ser Glu Pro Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            100                 105                 110         


Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly 
        115                 120                 125             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    130                 135                 140                 


Ser Gly Asn Trp His Cys Asp Ser Thr Arg Leu Gly Asp Arg Val Ile 
145                 150                 155                 160 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                165                 170                 175     


Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn Val 
            180                 185                 190         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        195                 200                 205             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    210                 215                 220                 


Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln 
225                 230                 235                 240 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                245                 250                 255     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            260                 265                 270         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        275                 280                 285             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    290                 295                 300                 


Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
305                 310                 315                 320 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                325                 330                 335     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Gly 
            340                 345                 350         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg 
        355                 360                 365             


Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln Phe 
    370                 375                 380                 


Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp Leu 
385                 390                 395                 400 


Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp Gln 
                405                 410                 415     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            420                 425                 430         


Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His 
        435                 440                 445             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe 
    450                 455                 460                 


Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met 
465                 470                 475                 480 


Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Glu 
                485                 490                 495     


Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Ser Thr Ala Ala Gln 
            500                 505                 510         


Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        515                 520                 525             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    530                 535                 540                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
545                 550                 555                 560 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                565                 570                 575     


Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            580                 585                 590         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        595                 600                 605             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    610                 615                 620                 


Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val 
625                 630                 635                 640 


Tyr Ser Glu Pro 
                


<210> 4741
<211> 1933
<212> DNA
<213> Adeno-associated virus

<400> 4741
caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc       60

cgacgccgag tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg      120

agcagtcttc caggccaaaa agcgggttct cgaacctctt ggtctggttg agacgccagc      180

taagacggca cctggaaaga agcgaccggt agactcgcca gactccacct cgggcatcgg      240

caagaaaggc cagcagcccg cgaaaaagag actcaacttt gggcagactg gcgactcaga      300

gccagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc      360

tggtacaatg gctgcaggcg gtggcgcacc aatggctgac aataacgagg gcgccgacgg      420

agtgggtaat gcctcaggaa attggcattg cgattccaca cggctgggcg acagagtcat      480

caccaccagc acccgaacct gggccctgcc cacctacaac aaccacctct acaagcaaat      540

ctccagtcag tcagcaggga gcaccaacga taacgtctat ttcggctaca gcaccccctg      600

ggggtatttt gacttcaaca gattccattg ccacttctca ccacgtgact ggcagcgact      660

tatcaacaac aactggggat tccggcccaa gaagctcaac ttcaagctct tcaacatcca      720

ggtcaaggag gtcacgacga atgacggcgt cacaaccatc gctaataacc ttaccagcac      780

ggttcaggtc ttttcggact cggaatatca actgccgtac gtcctcggct ccgcgcacca      840

gggctgcctg cctccgttcc cggcagacgt gttcatgatt ccgcagtacg gatacctgac      900

tctgaacaat ggcagccaat cggtaggccg ttcctccttc tactgcctgg agtactttcc      960

ttctcagatg ctgagaacgg gcaacaactt cacctttagc tacaccttcg aggacgtgcc     1020

tttccacagc agctacgcgc acagccagag tctgggccgg ctgatgaatc ccctcatcga     1080

ccagtacctg tactacttgg ccagaacaca gagcaacgca ggaggtactg ctggcaatcg     1140

ggaactgcag ttttatcagg gcggacctac caccatggcc gaacaagcaa agaactggct     1200

gcccggacct tgcttccggc aacagagagt atccaagacg ctggatcaaa ataacaacag     1260

caactttgcc tggactggtg ccacaaaata ccatttaaat ggaagaaatt cattggttaa     1320

tcccggtgtc gccatggcaa cccacaagga cgacgaggaa cgcttcttcc cttcgagcgg     1380

agttctaatt tttggcaaaa ctggagcagc taataaaact acattagaaa acgtgctcat     1440

gacaaatgaa gaagaaattc gtcctaccaa cccggtagct accgaggaat acgggattgt     1500

aagcagcaac ttgcaggcgg ctagcaccgc agcccagaca caagttgtta acaaccaggg     1560

agccttacct ggcatggtct ggcagaaccg ggacgtgtac ctgcaaggtc ccatttgggc     1620

caagattcct cacacggacg gcaactttca cccgtctcct ctaatgggtg gctttggact     1680

gaaacacccg cctccccaga tcctgatcaa aaacacaccg gtacctgcta atcctccaga     1740

agtgtttact cctgccaagt ttgcttcctt catcacgcag tacagcaccg ggcaagtcag     1800

cgttgagatc gaatgggagc tgcagaaaga gaacagcaag cgctggaacc cagagattca     1860

gtacacctcc aactttgaca aacagactgg agtggacttt gctgttgaca gccagggtgt     1920

ttactctgag cct                                                        1933


<210> 4742
<211> 644
<212> PRT
<213> Adeno-associated virus

<400> 4742
Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg 
1               5                   10                  15      


Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr 
            20                  25                  30          


Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg 
        35                  40                  45              


Val Leu Glu Pro Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro 
    50                  55                  60                  


Gly Lys Lys Arg Pro Val Asp Ser Pro Asp Ser Thr Ser Gly Ile Gly 
65                  70                  75                  80  


Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                85                  90                  95      


Gly Asp Ser Glu Pro Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            100                 105                 110         


Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly 
        115                 120                 125             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    130                 135                 140                 


Ser Gly Asn Trp His Cys Asp Ser Thr Arg Leu Gly Asp Arg Val Ile 
145                 150                 155                 160 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                165                 170                 175     


Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn Val 
            180                 185                 190         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        195                 200                 205             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    210                 215                 220                 


Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln 
225                 230                 235                 240 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                245                 250                 255     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            260                 265                 270         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        275                 280                 285             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    290                 295                 300                 


Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
305                 310                 315                 320 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                325                 330                 335     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Gly 
            340                 345                 350         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg 
        355                 360                 365             


Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln Phe 
    370                 375                 380                 


Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp Leu 
385                 390                 395                 400 


Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp Gln 
                405                 410                 415     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            420                 425                 430         


Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His 
        435                 440                 445             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe 
    450                 455                 460                 


Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met 
465                 470                 475                 480 


Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Glu 
                485                 490                 495     


Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Ser Thr Ala Ala Gln 
            500                 505                 510         


Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        515                 520                 525             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    530                 535                 540                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
545                 550                 555                 560 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                565                 570                 575     


Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            580                 585                 590         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        595                 600                 605             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    610                 615                 620                 


Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val 
625                 630                 635                 640 


Tyr Ser Glu Pro 
                


<210> 4743
<211> 1933
<212> DNA
<213> Adeno-associated virus

<400> 4743
caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc       60

cgacgccgag tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg      120

agcagtcttc caggccaaaa agcgggttct cgaacctctt ggtctggttg agacgccagc      180

taagacggca cctggaaaga agcgaccggt agactcgcca gactccacct cgggcatcgg      240

caagaaaggc cagcagcccg cgaaaaagag actcaacttt gggcagactg gcgactcaga      300

gtcagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc      360

tggtacaatg gctgcaggcg gtggcgcacc aatggctgac aatagcgagg gcgccgacgg      420

agtgggtaat gcctcaggaa attggcattg cgattccaca tggctgggcg acagagtcat      480

caccaccagc acccgaacct gggccctgcc cacctacaac aaccacctct acaagcaaat      540

ctccagtcag tcagcaggga gcaccaacga taacgtctat ttcggctaca gcaccccctg      600

ggggtatttt gacttcaaca gattccattg ccacttctca ccacgtgact ggcagcgact      660

tatcaacaac aactggggat tccggcccaa gaagctcaac ttcaagctct tcaacatcca      720

ggtcaaggag gtcacgacga atgacggtgt cacaaccatc gctaataacc ttaccagcac      780

ggttcaggtc ttttcggact cggaatatca actgccgtac gtcctcggct ccgcgcacca      840

gggctgcctg cctccgttcc cggcagacgt gttcatgatt ccgcagtacg gatacctgac      900

tctgaacaat ggcagccaat cggtaggccg ttcctccttc tactgcctgg agtactttcc      960

ttctcagatg ctgagaacgg gcaacaactt cacctttagc tacaccttcg aggacgtgcc     1020

tttccacagc agctacgcgc acagccagag tctggaccgg ctgatgaatc ccctcatcga     1080

ccagtacctg tactacttgg ccagaacaca gagcaacgca ggaggtactg ctggcaatcg     1140

ggaactgcag ttttatcagg gcggacctac caccatggcc gaacaagcaa agaactggct     1200

gcccggacct tgcttccggc aacagagagt atccaagacg ctggatcaaa ataacaacag     1260

caactttgcc tggactggtg ccacaaaata ccatttaaat ggaagaaatt cattggttaa     1320

tcccggtgtc gccatggcaa cccacaagga cgacgaggaa cgcttcttcc cttcgagcgg     1380

agttctaatt tttggcaaaa ctggagcagc taataaaact acattagaaa acgtgctcat     1440

gacaaatgaa gaagaaattc gtcctaccaa cccggtagct accgaggaat acgggattgt     1500

aagcagcaac ttgcaggcgg ctagcaccgc agcccagaca caagttgtta acaaccaggg     1560

agccttacct ggcatggtct ggcagaaccg ggacgtgtac ctgcaaggtc ccatttgggc     1620

caagattcct cacacggacg gcaactttca cccgtctcct ctaatgggtg gctttggact     1680

gaaacacccg cctccccaga tcctgatcaa aaacacaccg gtacctgcta atcctccaga     1740

agtgtttact cctgccaagc ttgcttcctt catcacgcag tacagcaccg ggcaagtcag     1800

cgttgagatc gagtgggagc tgcagaaaga gaacagcaag cgctggaacc cagagattca     1860

gtacacctcc aactttgaca aacagactgg agtggacttt gctgttgaca gccagggtgt     1920

ttactctgag cct                                                        1933


<210> 4744
<211> 644
<212> PRT
<213> Adeno-associated virus

<400> 4744
Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg 
1               5                   10                  15      


Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr 
            20                  25                  30          


Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg 
        35                  40                  45              


Val Leu Glu Pro Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro 
    50                  55                  60                  


Gly Lys Lys Arg Pro Val Asp Ser Pro Asp Ser Thr Ser Gly Ile Gly 
65                  70                  75                  80  


Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                85                  90                  95      


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            100                 105                 110         


Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly 
        115                 120                 125             


Ala Pro Met Ala Asp Asn Ser Glu Gly Ala Asp Gly Val Gly Asn Ala 
    130                 135                 140                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
145                 150                 155                 160 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                165                 170                 175     


Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn Val 
            180                 185                 190         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        195                 200                 205             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    210                 215                 220                 


Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln 
225                 230                 235                 240 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                245                 250                 255     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            260                 265                 270         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        275                 280                 285             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    290                 295                 300                 


Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
305                 310                 315                 320 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                325                 330                 335     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            340                 345                 350         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg 
        355                 360                 365             


Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln Phe 
    370                 375                 380                 


Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp Leu 
385                 390                 395                 400 


Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp Gln 
                405                 410                 415     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            420                 425                 430         


Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His 
        435                 440                 445             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe 
    450                 455                 460                 


Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met 
465                 470                 475                 480 


Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Glu 
                485                 490                 495     


Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Ser Thr Ala Ala Gln 
            500                 505                 510         


Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        515                 520                 525             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    530                 535                 540                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
545                 550                 555                 560 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                565                 570                 575     


Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Leu Ala Ser Phe Ile Thr 
            580                 585                 590         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        595                 600                 605             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    610                 615                 620                 


Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val 
625                 630                 635                 640 


Tyr Ser Glu Pro 
                


<210> 4745
<211> 1933
<212> DNA
<213> Adeno-associated virus

<400> 4745
caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc       60

cgacgccgag tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg      120

agcagtcttc caggccaaaa agcgggttct cgaacctctt ggtctggttg agacgccagc      180

taagacggca cctggaaaga agcgaccggt agactcgcca gactccacct cgggcatcgg      240

caagaaaggc cagcagcccg cgaaaaagag actcaacttt gggcagactg gcgactcaga      300

gtcagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc      360

tggtacaatg gctgcaggcg gtggcgcacc aatggctgac aataacgagg gcgccgacgg      420

agtgggtaat gcctcaggaa attggcattg cgattccaca tggctgggcg acagagtcat      480

caccaccagc acccgaacct gggccctgcc cacctacaac aaccacctct acaagcaaat      540

ctccagtcag tcagcaggga gcaccaacga taacgtctat ttcggctaca gcaccccctg      600

ggggtatttt gacttcaaca gattccattg ccacttctca ccacgtgact ggcagcgact      660

tatcaacaac aactggggat tccggcccaa gaagctcaac ttcaagctct tcaacatcca      720

ggtcaaggag gtcacgacga atgacggcgt cacaaccatc gctaataacc ttaccagcac      780

ggttcaggtc ttttcggacc cggaatatca actgccgtac gtcctcggct ccgcgcacca      840

gggctgcctg cctccgttcc cggcagacgt gttcatgatt ccgcagtacg gatacctgac      900

tctgaacaat ggcagccaat cggtaggccg ttcctccttc tactgcctgg agtactttcc      960

ttctcagatg ctgagaacgg gcaacaactt cacctttagc tacaccttcg aggacgtgcc     1020

tttccacagc agctacgcgc acagccagag tctggaccgg ctgatgaatc ccctcatcga     1080

ccagtacctg tactacttgg ccagaacaca gagcaacgca ggaggtactg ctggcaatcg     1140

ggaactgcag ttttatcagg gcggacctac caccatggcc gaacaagcaa agaactggct     1200

gcccggacct tgcttccggc aacagagagt atccaagacg ctggatcaaa ataacaacag     1260

caactttgcc tggactggtg ccacaaaata ccatttaaat ggaagaaatt cattggttaa     1320

tcccggtgtc gccatggcaa cccacaagga cgacgaggaa cgcttcttcc cttcgagcgg     1380

agttctaatt tttggcaaaa ctggagcagc taataaaact acattagaaa acgtgctcat     1440

gacaaatgaa gaagaaattc gtcctaccaa cccggtagct accgaggaat acgggattgt     1500

aagcagcaac ttgcaggcgg ctagcaccgc agcccagaca caagttgtta acaaccaggg     1560

agccttacct ggcatggtct ggcagaaccg ggacgtgtac ctgcaaggtc ccatttgggc     1620

caagattcct cacacggacg gcaactttca cccgtctcct ctaatgggtg gctttggact     1680

gaaacacccg cctccccaga tcctgatcaa aaacacaccg gtacctgcta atcctccaga     1740

agtgtttact cctgccaaga ttgcttcctt catcacgcag tacagcaccg ggcaagtcag     1800

cgttgagatc gagtgggagc tgcagaaaga gaacagcaag cgctggaacc cagagattca     1860

gtacacctcc aactttgaca aacagactgg agtggacttt gctgttgaca gccagggtgt     1920

ttactctgag cct                                                        1933


<210> 4746
<211> 644
<212> PRT
<213> Adeno-associated virus

<400> 4746
Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg 
1               5                   10                  15      


Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr 
            20                  25                  30          


Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg 
        35                  40                  45              


Val Leu Glu Pro Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro 
    50                  55                  60                  


Gly Lys Lys Arg Pro Val Asp Ser Pro Asp Ser Thr Ser Gly Ile Gly 
65                  70                  75                  80  


Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                85                  90                  95      


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            100                 105                 110         


Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly 
        115                 120                 125             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    130                 135                 140                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
145                 150                 155                 160 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                165                 170                 175     


Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn Val 
            180                 185                 190         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        195                 200                 205             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    210                 215                 220                 


Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln 
225                 230                 235                 240 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                245                 250                 255     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Pro Glu Tyr Gln Leu Pro 
            260                 265                 270         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        275                 280                 285             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    290                 295                 300                 


Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
305                 310                 315                 320 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                325                 330                 335     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            340                 345                 350         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg 
        355                 360                 365             


Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln Phe 
    370                 375                 380                 


Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp Leu 
385                 390                 395                 400 


Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp Gln 
                405                 410                 415     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            420                 425                 430         


Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His 
        435                 440                 445             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe 
    450                 455                 460                 


Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met 
465                 470                 475                 480 


Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Glu 
                485                 490                 495     


Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Ser Thr Ala Ala Gln 
            500                 505                 510         


Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        515                 520                 525             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    530                 535                 540                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
545                 550                 555                 560 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                565                 570                 575     


Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Ile Ala Ser Phe Ile Thr 
            580                 585                 590         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        595                 600                 605             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    610                 615                 620                 


Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val 
625                 630                 635                 640 


Tyr Ser Glu Pro 
                


<210> 4747
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4747
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Arg Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Val Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Ser Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Val His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Cys Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4748
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4748
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Ser Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Cys Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Val 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Leu 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Arg Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Glu Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4749
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4749
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Thr Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala Arg Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Gly Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4750
<211> 3121
<212> DNA
<213> Adeno-associated virus

<400> 4750
gaattcgccc ttcgcagaga ccaaagttca actgaaacga atcaaccggt ttattgatta       60

acaagcaatt acagattacg ggtgaggtaa cgggtgccga tggggcgagg ctcagaataa      120

gtgccatctg tgttaacagc aaagtccaca tttgtagatt tgtagtagtt ggaagtgtat      180

tgaatctctg ggttccagcg tttgctgttt tctttctgca gctcccattc aatttccacg      240

ctgacctgtc cggtgctgta ctgcgtgatg aacgacgcca gcttagcttg actgaaggta      300

gttggaggat ccgcgggaac aggtgtattc ttaatcagga tctgaggagg cgggtgtttc      360

agtccaaagc cccccatcag cggcgaggga tgaaagtttc cgtccgtgtg aggaatcttg      420

gcccagatag gaccctgcag gtacacgtcc cggttctgcc agaccatgcc aggtaaggct      480

ccttgactgt tgacggcccc tacaatagga gcggcgtttt gctgttgcag gttatcggcc      540

accacgccgt actgttctgt ggccactggg ttggtggttt taatttcttc ctcactggtt      600

agcataacgc tgctatagtc cacgttgcct tttccagctc cctgtttccc aaacattaag      660

actccgctgg acggaaaaaa tcgctcttcg tcgtccttgt gggttgccat agcgacaccg      720

ggatttacca gagagtctct gccattcaga tgatacttgg tggcaccggt ccaggcaaag      780

ttgctgttgt tattttgcga cagtgtcgtg gagacgcgtt gctgccggta gcagggcccg      840

ggtagccagt ttttggcctg agccgacatg ttattaggcc cggcctgaga aaatagcaac      900

tgctgagttc ctgcggtacc tcccgtggac tgagtccgag acaggtagta caggtactgg      960

tcgatgaggg ggttcatcag ccggtccagg ctttggctgt gcgcgtagct gctgtgaaaa     1020

ggcacgtcct caaactggta gctgaactca aagttgttgc ccgttctcag catttgagaa     1080

ggaaagtact ccaggcagta gaaggaggaa cggcccacgg cctgactgcc attgttcaga     1140

gtcaggtacc cgtactgagg aatcatgaag acgtccgccg ggaacggagg caggcagccc     1200

tggcgcgcag agccgaggac gtacgggagc tggtattccg agtccgtaaa gacctgaatc     1260

gtgctggtaa ggttattggc gatggtcttg gtgccttcat tctgcgtgac ctccttgacc     1320

tggatgttga agagcttgaa gttgagtctc ttgggccgga atccccagtt gttgttgatg     1380

agtcgctgcc agtcacgtgg tgagaagtgg cagtggaatc tgttaaagtc aaaatacccc     1440

cagggggtgc tgtagccgaa gtaggtgttg tcgttggtgc ttcctcccga agtcccgttg     1500

gagatttgct tgtagaggtg gttgttgtag gtggggaggg cccaggttcg ggtgctggtg     1560

gtgatgactc tgtcgcccag ccatgtggaa tcgcaatgcc aatttcctga ggaactaccc     1620

actccgtcgg cgccttcgtt attgtctgcc attggagcgc caccgcctgc agccattgta     1680

ccagatccca gaccagaggg gcctgcgggg ggttctccga ttggttgagg gtcgggcact     1740

gactctgagt cgccagtctg cccaaagttg agtctctttt tcgcgggctg ctggcctttc     1800

ttgccgatgc ccgtagtgga gtctggagaa cgctggggtg atggctctac cggtctcttc     1860

tttccaggag ccgtcttagc gccttcctca accagaccga gaggttcgag aacccgcttc     1920

ttggcctgga agactgctcg tccgaggttg cccccaaaag acgtatcttc ttgcagacgc     1980

tcctgaaact cggcgtcggc gtggttatac cgcaggtacg gattgtcacc cgctttgagc     2040

tgctggtcgt aggccttgtc gtgctcgagg gccgctgcgt ccgccgcgtt gacgggctcc     2100

cccttgtcga gtccgttgaa gggtccgagg tacttgtagc caggaagcac cagaccccgg     2160

ccgtcgtcct gcttttgctg gttggctttg ggcttcgggg ctccaggttt cagcgcccac     2220

cactcgcgaa tgccctcaga gaggttgtcc tcgagccaat ctggaagata accatcggca     2280

gccatacctg atctaaatca tttattgttc aaagatgcag tcatccaaat ccacattgac     2340

cagatcgcag gcagtgcaag cgtctggcac ctttcccatg atatgatgaa tgtagcacag     2400

tttctgatac gcctttttga cgacagaaac gggttgagat tctgacacgg gaaagcactc     2460

taaacagtct ttctgtccgt gagtgaagca gatatttgaa ttctgattca ttctctcgca     2520

ttgtctgcag ggaaacagca tcagattcat gcccacgtga cgagaacatt tgttttggta     2580

cctgtccgcg tagttgatcg aagcttccgc gtctgacgtc gatggctgcg caactgactc     2640

gcgcacccgt ttgggctcac ttatatctgc gtcactgggg gcgggtcttt tcttggctcc     2700

accctttttg acgtagaatt catgctccac ctcaaccacg tgatcctttg cccaccggaa     2760

aaagtctttg acttcctgct tggtgacctt cccaaagtca tgatccagac ggcgggtgag     2820

ttcaaatttg aacatccggt cttgcaacgg ctgctggtgt tcgaaggtcg ttgagttccc     2880

gtcaatcacg gcgcacatgt tggtgttgga ggtgacgatc acgggagtcg ggtctatctg     2940

ggccgaggac ttgcatttct ggtccacgcg caccttgctt cctccgagaa tggctttggc     3000

cgactccacg accttggcgg tcatcttccc ctcctcccac cagatcacca tcttgtcgac     3060

acagtcgttg aagggaaagt tctcattggt ccagttgacg cagccgtaga agggcgaatt     3120

c                                                                     3121


<210> 4751
<211> 3121
<212> DNA
<213> Adeno-associated virus

<400> 4751
gaattcgccc ttctacggct gcgtcaactg gaccaatgag aactttccct tcaacgactg       60

tgtcgacaag atggtgatct ggtgggagga ggggaagatg accgccaagg tcgtggagtc      120

ggccaaagcc attctcggag gaagcaaggt gcgcgtggac cagaaatgca agtcctcggc      180

ccagatagac ccgactcccg tgatcgtcac ctccaacacc aacatgtgcg ccgtgattga      240

cgggaactca acgaccttcg aacaccagca gccgttgcaa gaccggatgt tcaaatttga      300

actcacccgc cgtctggatc atgactttgg gaaggtcacc aagcaggaag tcaaagactt      360

tttccggtgg gcaaaggatc acgtggttga ggtggagcac gaattctacg tcaaaaaggg      420

tggagccaag aaaagacccg cccccagtga cgcagatata agtgagccca aacgggtgcg      480

cgagtcagtt gcgcagccat cgacgtcaga cgcggaagct tcgatcaact acgcagacag      540

gtaccaaaac aaatgttctc gtcacgcggg catgaatctg atgctgtttc cctgcagaca      600

atgcgagaga atgaatcaga attcaaatat ctgcttcact cacggacaga aagactgttt      660

agagtgcttt cccgtgtcag aatctcaacc cgtttctgtc gtcaaaaagg cgtatcagaa      720

actgtgctac attcatcata tcatgggaaa ggtgccagac gcttgcactg cctgcgatct      780

ggtcgatgtg gatttggatg actgcatctt tgaacaataa atgatttaaa tcaggtatgg      840

ctgccgatgg ttatcttcca gattggctcg aggacaacct ctctgagggc attcgcgagt      900

ggtgggcgct gaaacctgga gccccgaagc ccaaagccaa ccagcaaaag caggacggcg      960

gccggggtct ggtgcttcct ggctacaagt acctcggacc cttcaacgga ctcgacaagg     1020

gggagcccgt caacgcggcg gacgcagcgg ccctcgagca cgacaaggcc tacgaccagc     1080

agctcaaagc gggtgacaat ccgtacctgc ggtataacca cgccgacgcc gagtttcagg     1140

agcgtctgca agaagatacg tcttttgggg gcaacctcgg gcgagcagtc ttccaggcca     1200

agaagcgggt tctcgaacct ctcggtctgg ttgaggaagg cgctaagacg gctcctggaa     1260

agaagagacc ggtagagcca tcaccccagc gttctccaga ctcctctacg ggcatcggca     1320

agaaaggcca gcagcccgcg aaaaagagac tcaactttgg gcagactggc gactcagagt     1380

cagtgcccga ccctcaacca atcggagaac cccccgcagg cccctctggt ctgggatctg     1440

gtacaatggc tgcaggcggt ggcgctccaa tggcagacaa taacgaaggc gccgacggag     1500

tgggtagttc ctcaggaaat tggcattgcg attccacatg gctgggcgac tgagtcatca     1560

ccaccagcac ccgaacctgg gccctcccca cctacaacaa ccacctctac aagcaaatct     1620

ccaacgggac ttcgggagga agcaccaacg acaacaccta cttcggctac agcaccccct     1680

gggggtattt tgactttaac agattccact gccacttctc accacgtgac tggcagcgac     1740

tcatcaacaa caactgggga ttccggccca agagactcaa cttcaagctc ttcaacatcc     1800

aggtcaagga ggtcacgcag aatgaaggca ccaagaccat cgccaataac cttaccagca     1860

cgattcaggt ctttacggac tcggaatacc agctcccgta cgtcctcggc tctgcgcacc     1920

agggctgcct gcctccgttc ccggcggacg tcttcatgat tcctcagtac gggtacctga     1980

ctctgaacaa tggcagtcag gccgtgggcc gttcctcctt ctactgcctg gagtactttc     2040

cttctcaaat gctgagaacg ggcaacaact ttgagttcag ctaccagttt gaggacgtgc     2100

cttttcacag cagctacgcg cacagccaaa gcctggaccg gctgatgaac cccctcatcg     2160

accagtacct gtactacctg tctcggactc agtccacggg aggtaccgca ggaactcagc     2220

agttgctatt ttctcaggcc gggcctaata acatgtcggc tcaggccaaa aactggctac     2280

ccgggccctg ctaccggcag taacgcgtct ccacgacact gtcgcaaaat aacaacagca     2340

actttgtctg gaccggtgcc accaagtatc atctgaatgg cagagactct ctggtagatc     2400

ccggtgtcgc tatggcaacc cacaaggacg acgaagagcg attttttccg tccagcggag     2460

tcataatgtt tgggaaacag ggagctggaa aagacaacgt ggactatagc agcgtcatgc     2520

taaccagtga ggaagaaatt aaaaccacca acccagtggc cacagaacag tacggcgtgg     2580

tggccgataa cctgcaacag caaaacgccg ctcctattgt aggggccgtc aacagtcaag     2640

gagccttacc tggcatggtc tggcagaacc gggacgtgta cctgcagggt cctacctggg     2700

ccaagattcc tcacacggac ggaaactttc atccctcgcc gctgatggga ggctttggac     2760

tgaaacaccc gcctcctcag atcctgatta agaatacacc tgttcccgcg gatcctccaa     2820

ctaccttcag tcaagctaag ctggcgtcgt tcatcacgca gtacagcacc ggacaggtca     2880

gcgtggaaat tgaatgggag ctgcaggaag aaaacagcaa acgctggaac ccagagattc     2940

aatacacttc caactactac aaatctacaa atgtggactt tgctgttaac acagatggca     3000

cttattctga gcctcgcccc atcggcaccc gttacctcac ccgtaatctg taattgcttg     3060

ttaatcaata aaccggttga ttcgtttcag ttgaactttg gtctctgcga agggcgaatt     3120

c                                                                     3121


<210> 4752
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4752
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Gly Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Ser Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asp Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4753
<211> 3121
<212> DNA
<213> Adeno-associated virus

<400> 4753
gaattcgccc ttcgcgagac caaagttcaa ctgaaacgaa tcaaccggtt tattgattaa       60

caagcaatta cagattacgg gtgaggtaac gggtgccgat ggggcgaggc tcagaataag      120

tgccatctgt gttaacagca aagtccacat ttgtagattt gtagtagttg gaagtgtatt      180

gaatctctgg gttccagcgt ttgctgtttt ctttctgcag ctcccattca atttccacgc      240

tgacctgtcc ggtgctgtac tgcgtgatga acgacgccag cttagcttga ctgaaggtag      300

ttggaggatc cgcgggaaca ggtgtattct taatcaggat ctgaggaggc gggtgtttca      360

gtccaaagcc tcccatcagc ggcgagggat gaaagtttcc gtccgtgtga ggaatcttgg      420

cccagatagg accctgcagg tacacgtccc ggttctgcca gaccatgcca ggtaaggctc      480

cttgactgtt gacggcccct acaataggag cggcgttttg ctgttgcagg ttatcggcca      540

ccacgccgta ctgttctgtg gccactgggt tggtggtttt aatttcttcc tcactggtta      600

gcataacgct gctatagtcc acgttgtctt ttccagctcc ctgtttccca aacattaaga      660

ctccgctgga cggaaaaaat cgctcttcgt cgtccttgtg ggttgccata gcgacaccgg      720

gatttaccag agagtctctg ccattcagat gatacttggt ggcaccggtc caggcaaagt      780

tgctgttgtc attttgcgac agtgtcgtgg agacgcgttg ctgccggtag cagggcccgg      840

gtagccagtt tttggcctga gccgacatgt tattaggccc ggcctgagaa aatagcaact      900

gctgagttcc tgcggtacct cccgtggact gagtccgaga caggtagtac aggtactggt      960

cgatgagggg gttcatcagc cggtccaggc tttggctgtg cgcgtagctg ctgtgaaaag     1020

gcacgtcctc aaactggtag ctgaactcaa agttgttgcc cgttctcagc atttgagaag     1080

gaaagtactc caggcagtag aaggaggaac ggcccacggc ctgactgcca ttgttcagag     1140

tcaggtaccc gtactgagga atcatgaaga cgtccgccgg gaacggaggc aggcagccct     1200

ggtgcgcaga gccgaggacg tacgggagct ggtattccga gtccgtaaag acctgaatcg     1260

tgctggtaag gttattggcg atggtcttgg tgccttcatt ctgcgtgacc tccttgacct     1320

ggatgttgaa gagcttgaag ttgaggctct tgggccggaa tccccagttg ttgttgatga     1380

gtcgctgcca gtcacgtggt gagaagtggc agtggaatct gttaaagtca aaataccccc     1440

agggggtgct gtagccgaag taggtgttgt cgttggtgct tcctcccgaa gtcccgttgg     1500

agatttgctt gtagaggtgg ttgttgtagg tggggagggc ccaggttcgg gtgctggtgg     1560

tgatgactcc gtcgcccagc catgtggaat cgcaatgcca atttcctgag gaactaccca     1620

ctccgtcggc gccttcgtta ttgtctgcca ttggagcgcc accgcctgca gccattgtac     1680

cagatcccag accagagggg cctgcggggg gttctccgat tggttgaggg tcgggcactg     1740

actctgagtc gccagtctgc ccaaagttga gtctcttttt cgcgggctgc tggcctttct     1800

tgccgatgcc cgtagaggag tctggagaac gctggggtga tggctctacc ggtctcttct     1860

ttccaggagc cgtcttagcg ccttcctcaa ccagaccgag aggttcgaga acccgcttct     1920

tggcctggaa gactgctcgc ccgaggttgc ccccaaaaga cgtatcttct tgcagacgct     1980

cctgaaactc ggcgtcggcg tggttatacc gcaggtacgg attgtcaccc gctttgagct     2040

gctggtcgta ggccttgtcg tgctcgaggg ccgctgcgtc cgccgcgttg acgggctccc     2100

ccttgtcgag tccgttgaag ggtccgaggt acttgtagcc aggaagcacc agaccccggc     2160

cgtcgtcctg cttttgctgg ttggctttgg gcttcggggc tccaggtttc agcgcccacc     2220

actcgcgaat gccctcagag aggttgtcct cgagccaatc tggaagataa ccatcggcag     2280

ccatacctga tttaaatcat ttattgttca aagatgcagt catccaaatc cacattgacc     2340

agatcgcagg cagtgcaagc gtctggcacc tttcccatga tatgatgaat gtagcacagt     2400

ttctgatacg cctttttgac gacagaaacg ggttgagatt ctgacacggg aaagcactct     2460

aaacagtctt tctgtccgtg agtgaagcag atatttgaat tctgattcat tctctcgcat     2520

tgtctgcagg gaaacagcat cagattcatg cccacgtgac gagaacattt gttttggtac     2580

ctgtctgcgt agttgatcga agcttccgcg tctgacgtcg atggctgcgc aactgactcg     2640

cgcacccgtt tgggctcact tatatctgcg tcactggggg cgggtctttt cttggctcca     2700

ccctttttga cgtagaattc atgctccacc tcaaccacgt gatcctttgc ccaccggaaa     2760

aagtctttga cttcctgctt ggtgaccttc ccaaagtcat gatccagacg gcgggtgagt     2820

tcaaatttga acatccggtc ttgcaacggc tgctggtgtt cgaaggtcgt tgagttcccg     2880

tcaatcacgg cgcacatgtt ggtgttggag gtgacgatca cgggagtcgg gtctatctgg     2940

gccgaggact tgcatttctg gtccacgcgc accttgcttc ctccgagaat ggctttggcc     3000

gactccacga ccttggcggt catcttcccc tcctcccacc agatcaccat cttgtcgaca     3060

cagtcgttga agggaaagtt ctcattggtc cagttgacgc agccgtagaa agggcgaatt     3120

c                                                                     3121


<210> 4754
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 4754
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagtccct caacccaaag cgaaccaaca acaccaggac      120

aaccgtcggg gtcttgtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc cggtcaacga ggcggacgcg gcagccctcg aacacgacaa agcttacgac      240

cagcagctca aggccggtga caacccgtac ctcaagtaca accacgccga cgccgagttt      300

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaagg gggctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg agactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca ccagaacctg ggccctgccc acttacaaca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcagcttca agctcttcaa catccaagtt      960

agaggggtca cgcagaacga tggcacgacg actattgcca ataaccttac cagcacggtt     1020

caagtgttta cggactcgga gtatcagctc ccgtacgtgc tcgggtcggc gcaccaaggc     1080

tgtctcccgc cgtttccagc ggacgtcttc atggtccctc agtatggata cctcaccctg     1140

aacaacggaa gtcaagcggt gggacgctca tccttttact gcctggagta cttcccttcg     1200

cagatgctaa ggactggaaa taacttccaa ttcagctata ccttcgagga tgtacctttt     1260

cacagcagct acgctcacag ccagagtttg gatcgcttga tgaatcctct tattgatcag     1320

tatctgtact acctgaacag aacgcaagga acaacctctg gaacaaccaa ccaatcacgg     1380

ctgcttttta gccaggctgg gcctcagtct atgtctttgc aggccagaaa ttggctacct     1440

gggccctgct accggcaaca gagactttca aagactgcta acgacaacaa caacagtaac     1500

tttccttgga cagcggccag caaatatcat ctcaatggcc gcgactcgct ggtgaatcca     1560

ggaccagcta tggccagtca caaggacgat gaagaaaaat ttttccctat gcacggcaat     1620

ctaatatttg gcaaagaagg gacaacggca agtaacgcag aattagataa tgtaatgatt     1680

acggatgaag aagagattcg taccaccaat cctgtggcaa cagagcagta tggaactgtg     1740

gcaaataact tgcagagctc aaatacagct cccacgactg gaactgtcaa tcatcagggg     1800

gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca     1860

aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg     1920

aaacatccgc ctcctcaaat catgatcaaa aatactccgg taccggcaaa tcctccgacg     1980

actttcagcc cggccaagtt tgcttcattt atcactcagt actccactgg acaggtcagc     2040

gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agagattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtagacac taatggtgtt     2160

tatagtgaac ctcgccctat tggaacccgg tatctcacac gaaacttgtg a              2211


<210> 4755
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 4755
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Asn Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Ala Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Val Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Glu Gln Ile Ser Ser Glu Thr Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asp Pro Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asp Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Glu Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 4756
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 4756
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagtccct caacccaaag cgaaccaaca acaccaggac      120

aaccgtcggg gtcttgtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc cggtcaacga ggcggacgcg gcagccctcg aacacgacaa agcttacgac      240

cagcagctca aggccggtga caacccgtac ctcaagtaca accacgccga cgccgagttt      300

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaagg gggctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg agactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca ccagaacctg ggccctgccc acttacaaca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcagcttca agctcttcaa catccaagtt      960

agaggggtca cgcagaacga tggcacgacg actattgcca ataaccttac cagcacggtt     1020

caagtgttta cggactcgga gtatcagctc ccgtacgtgc tcgggtcggc gcaccaaggc     1080

tgtctcccgc cgtttccagc ggacgtcttc atggtccctc agtatggata cctcaccctg     1140

aacaacggaa gtcaagcggt gggacgctca tccttttact gcctggagta cttcccttcg     1200

cagatgctaa ggactggaaa taacttccaa ttcagctata ccttcgagga tgtacctttt     1260

cacagcagct acgctcacag ccagagtttg gatcgcttga tgaatcctct tattgatcag     1320

tatctgtact acctgaacag aacgcaagga acaacctctg gaacaaccaa ccaatcacgg     1380

ctgcttttta gccaggctgg gcctcagtct atgtctttgc aggccagaaa ttggctacct     1440

gggccctgct accggcaaca gagactttca aagactgcta acgacaacaa caacagtaac     1500

tttccttgga cagcggccag caaatatcat ctcaatggcc gcgactcgct ggtgaatcca     1560

ggaccagcta tggccagtca caaggacgat gaagaaaaat ttttccctat gcacggcaat     1620

ctaatatttg gcaaagaagg gacaacggca agtaacgcag aattagataa tgtaatgatt     1680

acggatgaag aagagattcg taccaccaat cctgtggcaa cagagcagta tggaactgtg     1740

gcaaataact tgcagagctc aaatacagct cccacgactg gaactgtcaa tcatcagggg     1800

gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca     1860

aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg     1920

aaacatccgc ctcctcaaat catgatcaaa aatactccgg taccggcaaa tcctccgacg     1980

actttcagcc cggccaagtt tgcttcattt atcactcagt actccactgg acaggtcagc     2040

gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agagattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtagacac taatggtgtt     2160

tatagtgaac ctcgccctat tggaacccgg tatctcacac gaaacttgta a              2211


<210> 4757
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4757
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Gly 
    130                 135                 140                 


Ala Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Arg Gly Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 4758
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4758
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Arg Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4759
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4759
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Arg Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asp Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4760
<211> 685
<212> PRT
<213> Adeno-associated virus

<400> 4760
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Thr Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ala Arg Thr Gln Ser Thr Thr Gly Ser Thr Arg Gly Leu Gln Phe His 
    450                 455                 460                 


Gln Ala Gly Pro Asn Thr Met Ala Glu Gln Ser Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Asn Ile Asp Ser Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Thr Asn Pro Gly Val Ala Met Ala Thr Asn Lys 
        515                 520                 525             


Asp Asp Glu Asp Gln Phe Phe Pro Ile Asn Gly Val Leu Val Phe Gly 
    530                 535                 540                 


Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met Thr 
545                 550                 555                 560 


Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr 
                565                 570                 575     


Gly Val Val Ser Ser Asn Leu Gln Ser Ser Thr Ala Gly Pro Gln Thr 
            580                 585                 590         


Gln Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Tyr Thr Ser Asn Tyr Tyr Lys 
                645                 650                 655     


Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu 
            660                 665                 670         


Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
        675                 680                 685 


<210> 4761
<211> 733
<212> PRT
<213> Adeno-associated virus

<400> 4761
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn Thr Tyr Phe Gly 
            260                 265                 270         


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His 
        275                 280                 285             


Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe 
    290                 295                 300                 


Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu 
305                 310                 315                 320 


Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser 
                325                 330                 335     


Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu 
            340                 345                 350         


Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe 
        355                 360                 365             


Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala 
    370                 375                 380                 


Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met 
385                 390                 395                 400 


Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Gln Phe Glu Asp Val 
                405                 410                 415     


Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met 
            420                 425                 430         


Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Ser 
        435                 440                 445             


Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu Phe Ser Gln Ala Gly 
    450                 455                 460                 


Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys 
465                 470                 475                 480 


Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Ser Gln Asn Asn Asn Ser 
                485                 490                 495     


Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp 
            500                 505                 510         


Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His Lys Gly Asp Glu 
        515                 520                 525             


Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly 
    530                 535                 540                 


Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val Met Leu Thr Ser Glu 
545                 550                 555                 560 


Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val 
                565                 570                 575     


Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala Pro Ile Val Gly Ala 
            580                 585                 590         


Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly 
    610                 615                 620                 


Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro 
                645                 650                 655     


Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn 
        675                 680                 685             


Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys 
    690                 695                 700                 


Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu 
705                 710                 715                 720 


Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Ser Leu 
                725                 730             


<210> 4762
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4762
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Pro Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Arg Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4763
<211> 733
<212> PRT
<213> Adeno-associated virus

<400> 4763
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Arg Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn Thr Tyr Phe Gly 
            260                 265                 270         


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His 
        275                 280                 285             


Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe 
    290                 295                 300                 


Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu 
305                 310                 315                 320 


Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser 
                325                 330                 335     


Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu 
            340                 345                 350         


Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe 
        355                 360                 365             


Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala 
    370                 375                 380                 


Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met 
385                 390                 395                 400 


Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Gln Phe Glu Asp Val 
                405                 410                 415     


Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met 
            420                 425                 430         


Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Ser 
        435                 440                 445             


Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu Phe Ser Gln Ala Gly 
    450                 455                 460                 


Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys 
465                 470                 475                 480 


Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Ser Gln Asn Asn Asn Ser 
                485                 490                 495     


Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp 
            500                 505                 510         


Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His Lys Gly Asp Glu 
        515                 520                 525             


Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly 
    530                 535                 540                 


Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val Met Leu Thr Ser Glu 
545                 550                 555                 560 


Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val 
                565                 570                 575     


Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala Pro Ile Val Gly Ala 
            580                 585                 590         


Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly 
    610                 615                 620                 


Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro 
                645                 650                 655     


Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn 
        675                 680                 685             


Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys 
    690                 695                 700                 


Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu 
705                 710                 715                 720 


Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730             


<210> 4764
<211> 3098
<212> DNA
<213> Adeno-associated virus

<400> 4764
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcttccg      180

cccagatcga tcccaccccc gtgatcgtca cttccaacac caacatgtgc gctgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttaca agaccggatg ttcaaatttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgacc gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaagggag agccggtcaa cgaggcagac gccgcggccc tcgagcacga caaggcctac     1080

gacaagcagc tcgagcaggg ggacaacccg tacctcaagt acaaccacgc cgacgccgag     1140

tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagacccat agaatccccc gactcctcca cgggcatcgg caagaaaggc     1320

cagcagcccg ctaaaaagaa gctcaacttt gggcagactg gcgactcaga gtcagtgccc     1380

gacccccaac ctctcggaga acctcccgcc gcgccctcag gtctgggatc tggtacaatg     1440

gctgcaggcg gtggcgcacc aatggcagac aataacgaag gcgccgacgg agtgggtaat     1500

gcctccggaa attggcattg cgattccaca tggctgggcg acagagtcat caccaccagc     1560

acccgcacct gggccctgcc cacctacaac aaccacctct acaagcagat atcaagtcag     1620

agcggggcta ccaacgacaa ccacttcttc ggctacagca ccccctgggg ctattttgac     1680

ttcaacagat tccactgcca cttctcacca cgtgactggc agcgactcat caacaacaac     1740

tggggattcc ggcccagaaa gctgcggttc aagttgttca acatccaggt caaggaggtc     1800

acgacgaacg acggcgttac gaccatcgct aataacctta ccagcacgat tcaggtcttc     1860

tcggactcgg agtaccaact gccgtacgtc ctcggctctg cgcaccaggg ctgcctccct     1920

ccgttccctg cggacgtgtt catgattcct cagtacggat atctgactct aaacaacggc     1980

agtcagtctg tgggacgttc ctccttctac tgcctggagt actttccttc tcagatgctg     2040

agaacgggca ataactttga attcagctac acctttgagg aagtgccttt ccacagcagc     2100

tatgcgcaca gccagagcct ggaccggctg atgaatcccc tcatcgacca gtacctgtac     2160

tacctggccc ggacccagag cactacgggg tccacaaggg agctgcagtt ccatcaggct     2220

gggcccaaca ccatggccga gcaatcaaag aactggctgc ccggaccctg ttatcggcag     2280

cagagactgt caaaaaacat agacagcaac aacaacagta actttgcctg gaccggggcc     2340

actaaatacc atctgaatgg tagaaattca ttaaccaacc cgggcgtagc catggccacc     2400

aacaaggacg acgaggacca gttctttccc atcaacggag tgctggtttt tggcgaaacg     2460

ggggctgcca acaagacaac gctggaaaac gtgctaatga ccagcgagga ggagatcaaa     2520

accaccaatc ccgtggctac agaagaatac ggtgtggtct ccagcaacct gcaatcgtct     2580

acggccggac cccagacaca gactgtcaac agccaggggg ctctgcccgg catggtctgg     2640

cagaaccggg acgtgtacct gcagggtccc atctgggcca aaattcctca cacggacggc     2700

aactttcacc cgtctcccct gatgggcgga tttggactca aacacccgcc tcctcaaatt     2760

ctcatcaaaa acaccccggt acctgctaat cctccagagg tgtttactcc tgccaagttt     2820

gcctcattta tcacgcagta cagcaccggc caggtcagcg tggagatcga gtgggaactg     2880

cagaaagaaa acagcaaacg ctggaatcca gagattcagt acacctcaaa ttatgccaag     2940

tctaataatg tggaatttgc tgtcaacaac gaaggggttt atactgagcc tcgccccatt     3000

ggcacccgtt acctcacccg taacctgtaa ttgcctgtta atcaataaac cggttaattc     3060

gtttcagttg aactttggtc tctgcgaagg gcgaattc                             3098


<210> 4765
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4765
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Glu Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4766
<211> 733
<212> PRT
<213> Adeno-associated virus

<400> 4766
Met Ala Ala Asp Gly His Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn Thr Tyr Phe Gly 
            260                 265                 270         


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His 
        275                 280                 285             


Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Ser Trp Gly Phe 
    290                 295                 300                 


Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu 
305                 310                 315                 320 


Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser 
                325                 330                 335     


Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu 
            340                 345                 350         


Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe 
        355                 360                 365             


Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala 
    370                 375                 380                 


Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met 
385                 390                 395                 400 


Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Gln Phe Glu Asp Val 
                405                 410                 415     


Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met 
            420                 425                 430         


Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Ser 
        435                 440                 445             


Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu Phe Ser Gln Ala Gly 
    450                 455                 460                 


Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys 
465                 470                 475                 480 


Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser Gln Asn Asn Asn Ser 
                485                 490                 495     


Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp 
            500                 505                 510         


Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His Lys Asp Asp Glu 
        515                 520                 525             


Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly 
    530                 535                 540                 


Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val Met Leu Thr Ser Glu 
545                 550                 555                 560 


Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val 
                565                 570                 575     


Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala Pro Ile Val Gly Ala 
            580                 585                 590         


Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly 
    610                 615                 620                 


Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro 
                645                 650                 655     


Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn 
        675                 680                 685             


Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys 
    690                 695                 700                 


Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu 
705                 710                 715                 720 


Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730             


<210> 4767
<211> 2495
<212> DNA
<213> Adeno-associated virus

<400> 4767
gaattcgccc tttctacggc tgcgtcaact agaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattcatcat ctgctggggc gggctcccga gattgcttgc tcggcctgcg      180

atctggtcaa cgtggacctg gatgactgtg tttctgagca ataaatgact taaaccaggt      240

atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc      300

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      360

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      420

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      480

aagcagctcg agcaggggga caacccgtac ctcaagtaca accacgccga cgccgagttt      540

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      600

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      660

ggaaagaaga gacccataga atcccccgac tcctccacgg gcatcggcaa gaaaggccag      720

cagcccgcta aaaagaagct caactttggg cagactggcg actcagagtc agtgcccgac      780

cctcaaccaa tcggagaacc ccccgcaggc ccctctggtc tgggatctgg tacaatggct      840

gcaggcggtg gcgctccaat ggcagacaat aacgaaggcg ccgacggagt gggtaatgcc      900

tccggaaatt ggcattgcga ttccacatgg ctgggcgaca gagtcatcac caccagcacc      960

cgcacctggg ccctgcccac ctacaacaac cacctctaca agcagatatc aagtcagagc     1020

ggggctacca acgacaacca cttcttcggc tacagcaccc cctggggcta ttttgacttc     1080

aacagattcc actgccactt ctcaccacgt gactggcagc gactcatcaa caacaactgg     1140

ggattccggc ccagaaagct gcggttcaag ttgttcaaca tccaggtcaa ggaggtcacg     1200

acgaacgacg gcgttacgac catcgctaat aaccttacca gcacgattca ggtcttctcg     1260

gactcggagt accaactgcc gtacgtcctc ggctctgcgc accagggctg cctccctccg     1320

ttccctgcgg acgtgttcat gattcctcag tacggatatc tgactctaaa caacggcagt     1380

cagtctgtgg gacgttcctc cttctactgc ctggagtact ttccttctca gatgctgaga     1440

acgggcaata actttgaatt cagctacacc tttgaggaag tgcctttcca cagcagctat     1500

gcgcacagcc agagcctgga ccggctgatg aatcccctca tcgaccagta cctgtactac     1560

ctggcccgga cccagagcac tacggggtcc acaagggagc tgcagttcca tcaggctggg     1620

cccaacacca tggccgagca atcaaagaac tggctgcccg gaccctgtta tcggcagcag     1680

agactgtcaa aaaacataga cagcaacaac accagtaact ttgcctggac cggggccact     1740

aaataccatc tgaatggtag aaattcatta accaacccgg gcgtagccat ggccaccaac     1800

aaggacgacg aggaccagtt ctttcccatc aacggagtgc tggtttttgg caaaacgggg     1860

gctgccaaca agacaacgct ggaaaacgtg ctaatgacca gcgaggagga gatcaaaacc     1920

accaatcccg tggctacaga acagtacggt gtggtctcca gcaacctgca atcgtctacg     1980

gccggacccc agacacagac tgtcaacagc cagggggctc tgcccggcat ggtctggcag     2040

aaccgggacg tgtacctgca gggtcccatc tgggccaaaa ttcctcacac ggacggcaac     2100

tttcacccgt ctcccctgat gggcggattt ggactcaaac acccgcctcc tcaaattctc     2160

atcaaaaaca ccccggtacc tgctaatcct ccagaggtgt ttactcctgc caagtttgcc     2220

tcatttatca cgcagtacag caccggccag gtcagcgtgg agatcgagtg ggaactgcag     2280

aaagaaaaca gcaaacgctg gaatccagag attcagtaca cctcaaatta tgccaagtct     2340

aataatgtgg aatttgctgt caacaacgaa ggggtttata ctgagcctcg ccccattggc     2400

acccgttacc tcacccgtaa cctgtaattg cctgttaatc aataaaccgg ttaattcgtt     2460

tcagttgaac tttggtctct gcgaagggcg aattc                                2495


<210> 4768
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4768
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Thr Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4769
<211> 2504
<212> DNA
<213> Adeno-associated virus

<400> 4769
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattcatcat ctgctggggc gggctcccga gattgcttgc tcggcctgcg      180

atctggtcaa cgtggacctg gatgactgtg tttctgagca ataaatgact taaaccaggt      240

atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc      300

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      360

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      420

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      480

aagcagctcg agcaggggga caacccgtac ctcaagtaca accacgccga cgccgagttt      540

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      600

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      660

ggaaagaaga gacccataga atcccccgac tcctccacgg gcatcggcaa gaaaggccag      720

cagcccgcta aaaagaagct caactttggg cagactggcg actcagagtc agtgcccgac      780

cctcaaccaa tcggagaacc ccccgcaggc ccctctggtc tgggatctgg tacaatggct      840

gcaggcggtg gcgctccaat ggcagacaat aacgaaggcg ccgacggagt gggtaatgcc      900

tccggaaatt ggcattgcga ttccacatgg ctgggcgaca gagtcatcac caccagcacc      960

cgcacctggg ccctgcccac ctacaacaac cacctctaca agcagatatc aagtcagagc     1020

ggggctacca acgacaacca cttcttcggc tacagcaccc cctggggcta ttttgacttc     1080

aacagattcc actgccactt ctcatcacgt gactggcagc gactcatcaa caacaactgg     1140

ggattccggc ccaagagact caacttcaag ctcttcaaca tccaggtcaa ggaggtcacg     1200

cagaatgaag gcaccaagac catcgccaat aaccttacca gcacgattca ggtctttacg     1260

gactcggaat accggctccc gtacgtcctc ggctctgcgc accagggctg cctgcctccg     1320

ttcccggcgg acgtcttcat gattcctcag tacgggtacc tgactctgaa caacggcagt     1380

caggccgtgg gccgttcctc cttctactgc ctggagtact ttccttctca aatgctgaga     1440

acgggcaaca actttgagtt cagctaccag tttgaggacg tgccttttca cagcagctac     1500

gcgcacagcc aaagcctgga ccggctgatg aaccccctca tcgaccagta cctgtactac     1560

ctgtctcgga ctcagtccac gggaggtacc gcaggaactc agcagttgct attttctcag     1620

gccgggccta ataacatgtc ggctcaggcc aaaaactggc tacccgggcc ctgctaccgg     1680

cagcaacgcg tctccacgac actgtcgcaa aataacaaca gcaactttgc ttggaccggt     1740

gccaccaagt atcatctgaa tggcagagac tctctggtaa atcccggtgt cgctatggca     1800

acgcacaagg acgacgaaga gcgatttttt ccatccagcg gagtcttgat gtttgggaaa     1860

cagggagctg gaaaagacaa cgtggactat agcagcgtta tgctaaccag tgaggaagaa     1920

atcaaaacca ccaacccagt ggccacagaa cagtacggcg tggtggccga taacctgcaa     1980

cagcaaaacg ccgctcctat tgtaggggcc gtcaacagtc aaggagcctt acctggcatg     2040

gtctggcaga accgggacgt gtacctgcag ggtcctatct gggccaagat tcctcacacg     2100

gacggcaact ttcatccttc gccgctgatg ggaggctttg gactgaaaca cccgcctcct     2160

cagatcctga ttaagaatac acctgttccc gcggatcctc caactacctt cagtcaagcc     2220

aagccggcgt cgttcatcac gcagtacagc accggacagg tcagcgtgga aattgaatgg     2280

gagctgcaga aagagaacag caagcgctgg aacccagaga ttcagtatac ttccaactac     2340

tacaaatcta caaatgtgga ctttgctgtc aatactgagg gtacttattc agagcctcgc     2400

cccattggca cccgttacct cacccgtaac ctgtaattgc ctgttaatca ataaaccggt     2460

taattcgttt cagttgaact ttggtctctg cgaagggcga attc                      2504


<210> 4770
<211> 731
<212> PRT
<213> Adeno-associated virus

<400> 4770
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Ser Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Thr Asp Ser Glu Tyr Arg Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Gln Phe Glu Asp Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Ser Thr Gly 
        435                 440                 445             


Gly Thr Ala Gly Thr Gln Gln Leu Leu Phe Ser Gln Ala Gly Pro Asn 
    450                 455                 460                 


Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg 
465                 470                 475                 480 


Gln Gln Arg Val Ser Thr Thr Leu Ser Gln Asn Asn Asn Ser Asn Phe 
                485                 490                 495     


Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu 
            500                 505                 510         


Val Asn Pro Gly Val Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg 
        515                 520                 525             


Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly Ala Gly 
    530                 535                 540                 


Lys Asp Asn Val Asp Tyr Ser Ser Val Met Leu Thr Ser Glu Glu Glu 
545                 550                 555                 560 


Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala 
                565                 570                 575     


Asp Asn Leu Gln Gln Gln Asn Ala Ala Pro Ile Val Gly Ala Val Asn 
            580                 585                 590         


Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr 
        595                 600                 605             


Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe 
    610                 615                 620                 


His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro 
625                 630                 635                 640 


Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Thr 
                645                 650                 655     


Phe Ser Gln Ala Lys Pro Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
            660                 665                 670         


Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
        675                 680                 685             


Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Thr 
    690                 695                 700                 


Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu Pro Arg 
705                 710                 715                 720 


Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730     


<210> 4771
<211> 731
<212> PRT
<213> Adeno-associated virus

<400> 4771
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Arg Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Arg Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Gln Phe Glu Asp Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Ser Thr Gly 
        435                 440                 445             


Gly Thr Ala Gly Thr Gln Gln Leu Leu Phe Ser Gln Ala Gly Pro Asn 
    450                 455                 460                 


Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg 
465                 470                 475                 480 


Gln Gln Arg Val Ser Thr Thr Leu Ser Gln Asn Asn Asn Ser Asn Phe 
                485                 490                 495     


Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu 
            500                 505                 510         


Val Asn Pro Gly Val Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg 
        515                 520                 525             


Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly Ala Gly 
    530                 535                 540                 


Lys Asp Asn Val Asp Tyr Ser Ser Val Met Leu Thr Ser Glu Glu Glu 
545                 550                 555                 560 


Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala 
                565                 570                 575     


Asp Asn Leu Gln Gln Gln Asn Ala Ala Pro Ile Val Gly Ala Val Asn 
            580                 585                 590         


Ser Gln Gly Ala Leu Pro Gly Met Ala Trp Gln Asn Arg Asp Val Tyr 
        595                 600                 605             


Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe 
    610                 615                 620                 


His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro 
625                 630                 635                 640 


Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Thr 
                645                 650                 655     


Phe Ser Gln Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
            660                 665                 670         


Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
        675                 680                 685             


Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Thr 
    690                 695                 700                 


Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu Pro Arg 
705                 710                 715                 720 


Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730     


<210> 4772
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4772
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4773
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4773
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Arg Lys Leu Arg Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Thr Asp Asp Gly Val Thr Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ala Arg Thr Gln Ser Thr Thr Gly Ser Thr Arg Glu Leu Gln Phe His 
    450                 455                 460                 


Gln Ala Gly Pro Asn Thr Met Ala Glu Gln Ser Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Asn Ile Asp Ser Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Thr Asn Pro Gly Val Ala Met Ala Thr Asn Lys 
        515                 520                 525             


Asp Asp Glu Asp Gln Phe Phe Pro Ile Asn Gly Val Leu Val Phe Gly 
    530                 535                 540                 


Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met Thr 
545                 550                 555                 560 


Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr 
                565                 570                 575     


Gly Val Val Ser Ser Asn Leu Gln Ser Ser Thr Ala Gly Pro Gln Thr 
            580                 585                 590         


Gln Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly Asn Phe His Pro Ser Pro Leu Met Asp Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Ala Lys Ser Asn Asn Val Glu Phe Ala Val Asn Asn Glu Gly Val Tyr 
705                 710                 715                 720 


Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4774
<211> 3128
<212> DNA
<213> Adeno-associated virus

<400> 4774
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcttccg      180

cccagatcga tcccaccccc gtgatcgtca cttccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttaca agaccggatg ttcaaatttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctag ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca ccccagcgtt ctccagactc ctctacgggc     1320

atcggcaaga caggccagca gcccgcgaaa aagagactca actttgggca gactggcgac     1380

tcagagtcag tgcccgaccc tcaaccaatc ggagaacccc ccgcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctccccacct acaacaacca cctctacaag     1620

caaatctcca acgggacatc gggaggaagc accaacgaca acacctactt cggctacagc     1680

accccctggg ggtattttga ctttaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaacaa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtctt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tacctgactc tgaacaacgg cagtcaggcc gtgggccgtt cctccttcta ctgcctggag     2040

tactttcctt ctcaaatgct gagaacgggc aacaactttg agttcagcta ccagtttgag     2100

gacgtgcctt ttcacagcag ctacgcgcac agccaaagcc tggaccggct gatgaacccc     2160

ctcatcgacc agtacctgta ctacctgtct cggactcagt ccacgggagg taccgcagga     2220

actcagcagt tgctattttc tcaggccggg cctaataaca tgtcggctca ggccaaaaac     2280

tggctacccg ggccctgcta ccggcagcaa cgcgtctcca cgacactgtc gcaaaataac     2340

aacagcaact ttgcttggac cggtgccacc aagtatcatc tgaatggcag agactctctg     2400

gtaaatcccg gtgtcgctat ggcaacgcac aaggacgacg aagagcgatt ttttccatcc     2460

agcggagtct tgatgtttgg gaaacaggga gctggaaaag acaacgtgga ctatagcagc     2520

gttatgctaa ccagtgagga agaaatcaaa accaccaacc cagtggccac agaacagtac     2580

ggcgtggtgg ccgataacct gcaacagcaa aacgccgctc ctattgtagg ggccgtcaac     2640

agtcaaggag ccttacctgg catggtctgg cagaaccggg acgtgtacct gcagggtcct     2700

atctgggcca agattcctca cacggacggc aactttcatc cttcgccgct gatgggaggc     2760

tttggactga aacacccgcc tcctcagatc ctgattaaga atacacctgt tcccgcggat     2820

cctccaacta ccttcagtca agccaagctg gcgtcgttca tcacgcagta cagcaccgga     2880

caggtcagcg tggaaattga atgggagctg cagaaagaga acagcaagcg ctggaaccca     2940

gagattcagt atacttccaa ctactacaaa tctacaaatg tggactttgc tgtcaatact     3000

gagggtactt attcagagcc tcgccccatt ggcacccgtt acctcacccg taacctgtaa     3060

ttgcctgtta atcaataaac cggctaattc gtttcagttg aactttggtc tctgcgaagg     3120

gcgaattc                                                              3128


<210> 4775
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4775
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4776
<211> 3084
<212> DNA
<213> Adeno-associated virus

<400> 4776
gaattcgccc tttctacggc tgcatcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgca ggaccggatg ttcaagttcg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac caagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gcggagccag caaaagaccc gcccccgatg acgcggatat aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

aaacgtgcga gaaaatgaat cagaatttca acatttgctt cacgcacggg gtcagagact      660

gctcagaatg tttccccggt gcatcagaat ctcaaccggt cgtcagaaaa aaaacgtatc      720

agaaactgtg tgccattcat catctgctgg ggcgggcacc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggacgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggcttgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacctgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca cctcagcgtt cccccgactc ctccacgggc     1320

atcggcaaga aaggccacca gcccgcgaga aagagactga actttgggca gactggcgac     1380

tcggagtcag tccccgaccc tcaaccaatc ggagaaccac cagcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctgcccacct acaacaacca tctctacaag     1620

caaatctcca acgggacatc gggaggaagc actaacgaca acacctactt tggctacagc     1680

accccctggg ggtattttga cttcaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaataa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtgtt tacggactcg gaataccagc tcccgtacgt ccccggctct     1920

gcgcaccagg gctgcctccc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tatctgaccc taaacaatgg cagtcaggct gtgggccgtt cctccttcta ctgcctggaa     2040

tacttccctt ctcaaatgct gaggacgggc aacaactttg aattcagcta caccttcgag     2100

gacgtgcctt tccacagcag ctacgcgcac agccagagcc tggaccggct gatgaaccct     2160

ctcatcgacc agtacctgta ttacttatcc agaactcagt ccacaggagg aactcaaggt     2220

actcagcaat tgttattttc tcaagccggg cccgcaaaca tgtcggctca ggccaagaac     2280

tggctacctg gaccgtgtta ccgtcagcaa cgagtttcca cgacactgtc gcaaaacaac     2340

aacagcaatt ttgcttggac cggtgccacc aagtatcacc tgaatggcag agactccctg     2400

gttaatcccg gcgttgccat ggctacccac aaggacgacg aggagcgctt cttcccgtca     2460

agcggagttc taatgtttgg caagcagggg gctggaaaag acaatgtgga ctacagcagc     2520

gtgatgctca ccagcgaaga agaaattaaa actactaacc cagtggctac agagcagtat     2580

ggtgtggtgg cagacaacct gcagcagacc aacggagctc ccattgtggg aactgtcaac     2640

agccaggggg ccttacctgg tatggtctgg caaaaccggg acgtgtacct gcagggcccc     2700

atctgggcca aaattcctca cacggacggc aactttcatc cttcgccgct gatgggaggc     2760

tttggactga aacacccgcc tcctcagatc ctggtgaaaa acactcctgt tcctgcggat     2820

cctccgacca ccttcagcca ggccaagctg gcttctttta tcacgcagta cagcaccgga     2880

caggtcagcg tggaaatcga atgggagctg cagaaagaaa acagcaagcg ctggaaccca     2940

gagattcagt atacttccaa ctactacaaa tctacaaatg tggactttgc tgtcaatact     3000

gagggtactt attcagagcc tcgccccatt ggcactcgtt atctcacccg taatctgtaa     3060

ttgcttgtta atcaataaac cggt                                            3084


<210> 4777
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4777
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Pro Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Gly Ala 
            580                 585                 590         


Pro Ile Val Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Val Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4778
<211> 3123
<212> DNA
<213> Adeno-associated virus

<400> 4778
gaattcgccc ttggctgcgt caactggacc aatgagaact ttcccttcaa cgattgcgtc       60

gacaagatgg tgatctggtg ggaggagggc aagatgacgg ccaaggtcgt ggagtccgcc      120

aaggccattc tcggcggcag caaggtgcgc gtggaccaaa agtgcaagtc gtccgcccag      180

atcgacccca cccccgtgat cgtcacctcc aacaccaaca tgtgcgccgt gattgacggg      240

aacagcacca ccttcgagca ccagcagccg ttgcaggacc ggatgttcaa gttcgaactc      300

acccgccgtc tggagcacga ctttggcaag gtgaccaagc aggaagtcaa agagttcttc      360

cgctgggcgc aggatcacgt gaccgaggtg gcgcatgagt tctacgtcag aaagggcgga      420

gccagcaaaa gacccgcccc cgatgacgcg gatataagcg agcccaagcg ggcctgcccc      480

tcagtcgcgg atccatcgac gtcagacgcg gaaggagctc cggtggactt tgccgacagg      540

taccaaaaca aatgttctcg tcacgcgggc atgctccaga tgctgtttcc ctgcaaaacg      600

tgcgagagaa tgaatcagaa tttcaacatt tgcttcacgc acggggtcag agactgctca      660

gaatgtttcc ccggtgcatc agaatctcaa ccggtcgtca gaaaaaaaac gtatcagaaa      720

ctgtgtgcca ttcatcatct gctggggcgg gcacccgaga ttgcttgctc ggcctgcgat      780

ctggtcaacg tggacctgga cgactgtgtt tctgagcaat aaatgactta aaccaggtat      840

ggctgccgat ggttatcttc cagattggct tgaggacaac ctctctgagg gcattcgcga      900

gtggtgggac ctgaaacctg gagccccgaa acccaaagcc aaccagcaaa agcaggacga      960

cggccggggt ctggtgcttc ctggctacaa gtacctcgga cccttcaacg gactcgacaa     1020

gggggagccc gtcaacgcgg cggacgcagc ggccctcgag cacgacaagg cctacgacca     1080

gcagctcaaa gcgggtgaca atccgtacct gcggtataac cacgccgacg ccgagtttca     1140

ggagcgtctg caagaagata cgtcttttgg gggcaacctc gggcgagcag tcttccaggc     1200

caagaagcgg gttctcgaac ctctcggtct ggttgaggaa ggcgctaaga cggctcctgg     1260

aaagaagaga ccggtagagc catcacctca gcgttccccc gactcctcca cgggcatcgg     1320

caagaaaggc caccagcccg cgagaaagag actgaacttt gggcagactg gcgactcgga     1380

gtcagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc     1440

tggtacaatg gctgcaggcg gtggcgctcc aatggcagac aataacgaag gcgccgacgg     1500

agtgggtagt tcctcaggaa attggcattg cgattccaca tggctgggcg acagagtcat     1560

caccaccagc acccgaacct gggccctgcc cacctacaac aaccatctct acaagcaaat     1620

ctccaacggg acatcgggag gaagcactaa cgacaacacc tactttggct acagcacccc     1680

ctgggggtat tttgacttca acagattcca ctgccacttc tcaccacgtg actggcagcg     1740

actcatcaac aataactggg gattccggcc caagagactc aacttcaagc tcttcaacat     1800

ccaggtcaag gaggtcacgc agaatgaagg caccaagacc atcgccaata accttaccag     1860

cacgattcag gtgtttacgg actcggaata ccagctcccg tacgtcctcg gctctgcgca     1920

ccagggctgc ctccctccgt tcccggcgga cgtcttcatg attcctcagt acgggtatct     1980

gaccctaaac aatggcagtc aggctgtggg ccgttcctcc ttctactgcc tggaatactt     2040

cccttctcaa atgctgagga cgggcaacaa ctttgaattc agctacacct tcgaggacgt     2100

gcctttccac agcagctacg cgcacagcca gagcctggac cggctgatga accctctcat     2160

cgaccagtac ctgtattact tatccagaac tcagtccaca ggaggaactc aaggtactca     2220

gcaattgtta ttttctcaag ccgggcccgc aaacatgtcg gctcaggcca agaactggct     2280

acctggaccg tgttaccgtc agcaacgagt ttccacgaca ctgtcgcaaa acaacaacag     2340

caattttgct tggaccggtg ccaccaagta tcacctgaat ggcagagact ccctggttaa     2400

tcccggcgtt gccatggcta cccacaagga cgacgaggag cgcttcttcc cgtcaagcgg     2460

agttctaatg tttggcaagc agggggctgg aaaagacaat gtggactaca gcagcgtgat     2520

gctcaccagc gaagaagaaa ttaaaactac taacccagtg gctacagagc agtatggtgt     2580

ggtggcagac aacctgcagc agaccaacgg agctcccatt gtgggaactg tcaacagcca     2640

gggggcctta cctggtatgg tctggcaaaa ccgggacgtg tacctgcagg gccccatctg     2700

ggccaaaatt cctcacacgg acggcaactt tcatccttcg ccgctgatgg gaggctttgg     2760

actgaaacac ccgcctcctc agatcctggt gaaaaacact cctgttcctg cggatcctcc     2820

gaccaccttc agccaggcca agctggcttc ttttatcacg cagtacagca ccggacaggt     2880

cagcgtggaa atcgaatggg agctgcagaa agaaaacagc aagcgctgga acccagagat     2940

tcagtatact tccaactact acaaatctac aaatgtggac tttgctgtca atactgaggg     3000

tacttattca gagcctcgcc ccattggcac tcgttatctc acccgtaatc tgtaattgct     3060

tgttaatcaa taaaccggtt aattcgtttc agttgaactt tggtctctgc gaagggcgaa     3120

ttc                                                                   3123


<210> 4779
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4779
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Gly Ala 
            580                 585                 590         


Pro Ile Val Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Val Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4780
<211> 3122
<212> DNA
<213> Adeno-associated virus

<400> 4780
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgtgtgga ccaaaagtgc aagtcttccg      180

cccagatcga tcccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag cgccaccttc gagcaccagc agccgttgca ggaccggatg ttcaaatttg      300

aactcacccg ccgtctggag catgactttg gcaaggtgac gaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttccac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggatat aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgcgattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaagcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataatcacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagactggt agagcagtcg ccacaagagc cagactcctc ctcgggcatc     1320

ggcaagacag gccagcagcc cgctaaaaag agactcaatt ttggtcagac tggcgactca     1380

gagtcagtcc ccgacccaca acctctcgga gaacctccag cagccccctc aggtctggga     1440

cctaatacaa tggcttcagg cggtggcgct ccaatggcag acaataacga aggcgccgac     1500

ggagtgggta attcctcggg aaattggcat tgcgattcca catggctggg ggacagagtc     1560

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa     1620

atctccaacg gcacctcggg aggaagcacc aacgacaaca cctattttgg ctacagcacc     1680

ccctgggggt attttgactt caacagattc cactgtcact tttcaccacg tgactggcaa     1740

cgactcatca acaacaattg gggattccgg cccaaaagac tcaacttcaa gctgttcaac     1800

atccaggtca aggaagtcac gacgaacgaa ggcaccaaga ccatcgccaa taatctcacc     1860

agcaccgtgc aggtctttac ggactcggag taccagttac cgtacgtgct aggatccgct     1920

caccagggat gtctgcctcc gttcccggcg gacgtcttca cggttcctca gtacggctat     1980

ttaactttaa acaatggaag ccaagccctg ggacgttcct ccttctactg tctggagtat     2040

ttcccatcgc agatgctgag aaccggcaac aactttcagt tcagctacac cttcgaggac     2100

gtgcctttcc acagcagcta cgcgcacagc cagagcctgg acaggctgat gaatcccctc     2160

atcgaccagt acctgtacta cctggtcaga acgcaaacga ctggaactgg agggacgcag     2220

actctggcat tcagccaagc gggtcctagc tcaatggcca accaggctag aaattgggtg     2280

cccggacctt gctaccggca gcagcgcgtc tccacgacaa ccaaccagaa caacaacagc     2340

aactttgcct ggacgggagc tgccaagttt aagctgaacg gccgagactc tctaatgaat     2400

ccgggcgtgg caatggcttc ccacaaggat gacgacgacc gcttcttccc ttcgagcggg     2460

gtcctgattt ttggcaagca aggagccggg aacgatggag tggattacag ccaagtgctg     2520

attacagatg aggaagaaat caaggctacc aaccccgtgg ccacagaaga atatggagca     2580

gtggccatca acaaccaggc cgccaatacg caggcgcaga ccggactcgt gcacaaccag     2640

ggggtgattc ccggcatggt gtggcagaat agagacgtgt acctgcaggg tcccatctgg     2700

gccaaaattc ctcacacgga cggcaacttt cacccgtctc ccctgatggg cggctttgga     2760

ctgaagcacc cgcctcctca aattctcatc aagaacacac cggttccagc ggacccgccg     2820

cttaccttca accaggccaa gctgaactct ttcatcacgc agtacagcac cggacaggtc     2880

agcgtggaaa tcgagtggga gctgcagaaa gaaaacagca aacgctggaa tccagagatt     2940

caatacactt ccaactacta caaatctaca aatgtggact ttgctgtcaa cacggaagga     3000

gtttatagcg agcctcgccc cattggcacc cgttacctca cccgcaacct gtaattacat     3060

gttaatcaat aaaccggtta attcgtttca gttgaacttt ggtctctgcg aagggcgaat     3120

tc                                                                    3122


<210> 4781
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4781
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Leu Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Thr Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Asp Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 4782
<211> 3117
<212> DNA
<213> Adeno-associated virus

<400> 4782
gaattcgccc ttggctgcgt caactggacc aatgagaact ttcccttcaa cgattgcgtc       60

gacaagatgg tgatctggtg ggaggagggc aagatgacgg ccaaggtcgt ggagtccgcc      120

aaggccattc tcggcggcag caaggtgcgt gtggaccaaa agtgcaagtc ttccgcccag      180

atcgatccca cccccgtgat cgtcacctcc aacaccaaca tgtgcgccgt gattgacggg      240

aacagcacca ccttcgagca ccagcagccg ttgcaggacc ggatgttcaa atttgaactc      300

acccgccgtc tggagcatga ctttggcaag gtgacgaagc aggaagtcaa agagttcttc      360

cgctgggcgc aggatcacgt gaccgaggtg gcgcatgagt tccacgtcag aaagggtgga      420

gccaacaaga gacccgcccc cgatgacgcg gatataagcg agcccaagcg ggcctgcccc      480

tcagtcgcgg atccatcgac gtcagacgcg gaaggagctc cggtggactt tgccgacagg      540

taccaaaaca aatgttctcg tcacgcgggc atgcttcaga tgctgtttcc ctgcaagaca      600

tgcgagagaa tgaatcagaa tttcaacatt tgcttcacgc acgggaccag agactgttca      660

gaatgtttcc ccggcgtgtc agaatctcaa ccggtcgtca gaaagaggac gtatcggaaa      720

ctctgtgcga ttcatcatct gctggggcgg gctcccgaga ttgcttgctc ggcctgcgat      780

ctggtcaacg tggacctgga tgactgtgtt tctgagcaat aaatgactta aaccaggtat      840

ggctgccgat ggttatcttc cagattggct cgaggacaac ctctctgagg gcattcgcga      900

gtggtgggac ttgaaacctg gagccccgaa acccaaagcc aaccagcaaa agcaggacga      960

cggccggggt ctggtgcttc ctggctacaa gtacctcgga cccttcaacg gactcgacaa     1020

gggggagccc gtcaacgcgg cggacgcagc ggccctcgag cacgacaaag cctacgacca     1080

gcagctcaaa gcgggtgaca atccgtacct gcggtataat cacgccgacg ccgagtttca     1140

ggagcgtctg caagaagata cgtcttttgg gggcaacctc gggcgagcag tcttccaggc     1200

caagaagcgg gttctcgaac ctctcggtct ggttgaggaa ggcgctaaga cggctcctgg     1260

aaagaagaga ccggtagagc agtcgccaca agagccagac tcctcctcgg gcatcggcaa     1320

gacaggccag cagcccgcta aaaagagact caattttggt cagactggcg actcagagtc     1380

agtccccgac ccacaacctc tcggagaacc tccagcagcc ccctcaggtc tgggacctaa     1440

tacaatggct tcaggcggtg gcgctccaat ggcagacaat aacgaaggcg ccgacggagt     1500

gggtaattcc tcgggaaatt ggcattgcga ttccacatgg ctgggggaca gagtcatcac     1560

caccagcacc cgaacctggg ccctgcccac ctacaacaac cacctctaca agcaaatctc     1620

caacggcacc tcgggaggaa gcaccaacga caacacctat tttggctaca gcaccccctg     1680

ggggtatttt gacttcaaca gattccactg tcacttttca ccacgtgact ggcaacgact     1740

catcaacaac aattggggat tccggcccaa aagactcaac ttcaagctgt tcaacatcca     1800

ggtcaaggaa gtcacgacga acgaaggcac caagaccatc gccaataatc tcaccagcac     1860

cgtgcgggtc tttacggact cggagtacca gttaccgtac gtgctaggat ccgctcacca     1920

gggatgtctg cctccgttcc cggcggacgt cttcatggtt cctcagtacg gctatttaac     1980

tttaaacaat ggaagccaag ccctgggacg ttcctccttc tactgtctgg agtatttccc     2040

atcgcagatg ctgagaaccg gcaacaactt tcagttcagc tacaccttcg aggacgtgcc     2100

tttccacagc agctacgcgc acagccagag cctggacagg ctgatgaatc ccctcatcga     2160

ccagtacctg tactacctgg tcagaacgca aacgactgga actggaggga cgcagactct     2220

ggcattcagc caagcgggtc ctagctcaat ggccaaccag gctagaaatt gggtgcccgg     2280

accttgctac cggcagcagc gcgtctccac gacaaccaac cagagcaaca acagcaactt     2340

tgcctggacg ggagctgcca agtttaagct gaacggccga gactctctaa tgaatccggg     2400

cgtggcaatg gcttcccaca aggatgacga cgaccgcttc ttcccttcga gcggggtcct     2460

gatttttggc aagcaaggag ccgggaacga tggagtggat tacagccaag tgctgattac     2520

agatgaggaa gaaatcaagg ctaccaaccc cgtggccaca gaagaatatg gagcagtggc     2580

catcaacaac caggccgcca atacgcaggc gcagaccgga ctcgtgcaca accagggggt     2640

gattcccggc atggtgtggc agaatagaga cgtgtacctg cagggtccca tctgggccaa     2700

aattcctcac acggacggca actttcaccc gtctcccctg atgggcggct ttggactgaa     2760

gcacccgcct cctcaaattc tcatcaagaa cacaccggtt ccagcggacc cgccgcttac     2820

cttcaaccag gccaagctga actctttcat cacgcagtac agcaccggac aggtcagcgt     2880

ggaaatcgag tgggagctgc agaaagaaaa cagcaaacgc tggaatccag agattcaata     2940

cacttccaac tactacaaat ctacaaatgt ggactttgct gtcaacacgg aaggagttta     3000

tagcgagcct cgccccattg gcacccgtta cctcacccgc aacctgtaat tacatgttaa     3060

tcaataaacc ggttaattcg tttcagttga actttggtct ctgcgaaggg cgaattc        3117


<210> 4783
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4783
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Arg Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Ser 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Asp Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 4784
<211> 3121
<212> DNA
<213> Adeno-associated virus

<400> 4784
gaattcgccc ttctacggct gcgtcaactg gaccaatgag aactttccct tcaacgattg       60

cgtcgacaag atggtgatct ggtgggagga gggcaagatg acggccaagg tcgtggagtc      120

cgccaaggcc attctcggcg gcagcaaggt gcgtgtggac caaaagtgca agtcttccgc      180

ccagatcgat cccacccccg tgatcgtcac ctccaacacc aacatgtgcg ccgtgattga      240

cgggaacagc accaccttcg agcaccagca gccgttgcag gaccggatgt tcaaatttga      300

actcacccgc cgtctggagc atgactttgg caaggtgacg aagcaggaag tcaaagagtt      360

cttccgctgg gcgcaggatc acgtgaccga ggtggcgcat gagttccacg tcagaaaggg      420

tggcgccaac aagagacccg cccccgatga cgcggatata agcgagccca agcgggcctg      480

cccctcagtc gcggatccat cgacgtcaga cgcggaagga gctccggtgg actttgccga      540

caggtaccaa aacaaatgtt ctcgtcacgc gggcatgctt cagatgctgt ttccctgcaa      600

gacatgcgag agaatgaatc agaatttcaa catttgcttc acgcacggga ccagagactg      660

ttcagaatgt ttccccggcg tgtcagaatc tcaaccggtc gtcagaaaga ggacgtatcg      720

gaaactctgt gcgattcatc atctgctggg gcgggctccc gagattgctt gctcggcctg      780

cgatctggtc aacgtggacc tggatgactg tgtttctgag caataaatga cttaaaccag      840

gtatggctgc cgatggttat cttccagatt ggctcgagga caacctctct gagggcattc      900

gcgagtggtg ggacttgaaa cctggagccc cgaaacccaa agccaaccag caaaagcagg      960

acgacggccg gggtctggtg cttcctggct acaagtacct cggacccttc aacggactcg     1020

acaaggggga gcccgtcaac gcggcggacg cagcggccct cgagcacgac aaagcctacg     1080

accagcagct caaagcgggt gacaatccgt acctgcggta taatcacgcc gacgccgagt     1140

ttcaggagcg tctgcaagaa gatacgtcct ttgggggcaa cctcgggcga gcagtcttcc     1200

aggccaagaa gcgggttctc gaacctctcg gtctggttga ggaaggcgct aagacggctc     1260

ctggaaagaa gagaccggta gagcagtcgc cacaagagcc agactcctcc tcgggcatcg     1320

gcaagacagg ccagcagccc gctaaaaaga gactcaattt tggtcagact ggcgactcag     1380

agtcagtccc cgacccacaa cctctcggag aacctccagc agccccctca ggtctgggac     1440

ctaatacaat ggcttcaggc ggtggcgctc caatggcaga caataacgaa ggcgccgacg     1500

gagtgggtaa ttcctcggga aattggcatt gcgattccac atggctgggg gacagagtca     1560

tcaccaccag cacccgaacc tgggccctgc ccacctacaa caaccacctc tacaagcaaa     1620

tctccaacgg cacctcggga ggaagcacca acgacaacac ctattttggc tacagcaccc     1680

cctgggggta ttttgacttc aacagattcc actgtcactt ttcaccacgt gactggcaac     1740

gactcatcaa caacaattgg ggattccggc ccaaaagact caacttcaag ctgttcaaca     1800

tccaggtcaa ggaagtcacg acgaacgaag gcaccaagac catcgccaat aatctcacca     1860

gcaccgtgca ggtctttacg gacttggagt accagttacc gtacgtgcta ggatccgctc     1920

accagggatg tctgcctccg ttcccggcgg acgtcttcat ggttcctcag tacggctatt     1980

taactttaaa caatggaagc caagccctgg gacgttcctc cttctactgt ctggagtatt     2040

tcccatcgca gatgccgaga accggcaaca actttcagtt cagctacacc ttcgaggacg     2100

tgcctttcca cagcagctac gcgcacagcc agagcctgga caggctgatg aatcccctca     2160

tcgaccagta cctgtactac ctggtcagaa cgcaaacgac tggaactgga gggacgcaga     2220

ctctggcatt cagccaagcg ggtcctagct caatggccaa ccaggctaga aattgggtgc     2280

ccggaccttg ctaccggcag cagcgcgtct ccacgacaac caaccagaac aacaacagca     2340

actttgcctg gacgggagct gccaagttta agctgaacgg ccgagactct ctaatgaatc     2400

cgggcgtggc aatggcttcc cacaaggatg acgacgaccg cttcttccct tcgagcgggg     2460

tcctgatttt tggcaagcaa ggagccggga acgatggagt ggattacagc caagtgctga     2520

ttacagatga ggaagaaatc aaggctacca accccgtggc cacagaagaa tatggagcag     2580

tggccatcaa caaccaggcc gccaatacgc aggcgcagac cggactcgtg cacaaccagg     2640

gggtgattcc cggcatggtg tggcagaata gagacgtgta cctgcagggt cccatctggg     2700

ccaaaattcc tcacacggac ggcaactttc acccgtctcc cctgatgggc ggctttggac     2760

tgaagcaccc gcctcctcaa attctcatca agaacacacc ggttccagcg gacccgccgc     2820

ttaccttcaa ccaggccaag ctgaactctt tcatcacgca gtacagcacc ggacaggtca     2880

gcgtggaaat cgagtgggag ctgcagaaag aaaacagcaa acgctggaat ccagagattc     2940

aatacacttc caactactac aaatctacaa atgtggactt tgctgtcaac acggaaggag     3000

tttatagcga gcctcgcccc attggcaccc gttacctcac ccgcaacctg taattacatg     3060

ttaatcaata aaccggttaa ttcgtttcag ttgaactttg gtctctgcga agggcgaatt     3120

c                                                                     3121


<210> 4785
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4785
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Leu Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Pro Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Asp Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 4786
<211> 3122
<212> DNA
<213> Adeno-associated virus

<400> 4786
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgtgtgga ccaaaagtgc aagtcttccg      180

cccagatcga tcccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgca ggaccggatg ttcaaatttg      300

aactcacccg ccgtctggag catgactttg gcaaggtgac gaagcaggaa gtcaaagggt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttccac gtgcgagccc      420

aagcgggcct gcccctcagt cgcggatcca tcgacgtcag accagaaagg gtggagccaa      480

caagagaccc gcccccgatg acgcggatat aagcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgcgattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaagcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataatcacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagcagtcg ccacaagagc cagactcctc ctcgggcatc     1320

ggcaagacag gccagcagcc cgctaaaaag agactcaatt ttggtcagac tggcgactca     1380

gagtcagtcc ccgacccaca acctctcgga gaacctccag cagccccctc aggtctggga     1440

cctaatacaa tggcttcagg cggtggcgct ccaatggcag acaataacga aggcgccgac     1500

ggagtgggta attcctcggg aaattggcat tgcgattcca catggctggg ggacagagtc     1560

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa     1620

atctccaacg gcacctcggg aggaagcacc aacgacaaca cctattttgg ctacagcacc     1680

ccctgggggt attttgactt caacagattc cactgtcact tttcaccacg tgactggcaa     1740

cgactcatca acaacaattg gggattccgg cccaaaagac tcaacttcaa gctgttcaac     1800

atccaggtca aggaagtcac gacgaacgaa ggcaccaaga ccatcgccaa taatctcacc     1860

agcaccgtgc aggtctttac ggactcggag taccagttac cgtacgtgct aggatccgct     1920

caccagggat gtctgcctcc gttcccggcg gacgtcttca tggttcctca gtacggctat     1980

ttaactttaa acaatggaag ccaagccctg ggacgttcct ccttctactg tctggagtat     2040

ttcccatcgc agatgctgag aaccggcaac aactttcagt tcagctacac cttcgaggac     2100

gtgcctttcc acagcagcta cgcgcacagc cagagcctgg acaggctgat gaatcccctc     2160

atcgaccagt acctgtacta cctggtcaga acgcaaacga ctggaactgg agggacgcag     2220

actctggcat tcagccaagc gggtcctagc tcaatggcca accaggctag aaattgggtg     2280

cccggacctt gctaccggca gcagcgcgtc tccacgacaa ccaaccagaa caacaacagc     2340

aactttgcct ggacgggagc tgccaagttt aagctgaacg gccgagactc tctaatgaat     2400

ccgggcgtgg caatggcttc ccacaaggat gacgacgacc gcttcttccc ttcgagcggg     2460

gtcctgattt ttggcaagca aggagccggg aacgatggag tggattacag ccaagtgctg     2520

attacagatg aggaagaaat caaggctacc aaccccgtgg ccacagaaga atatggagca     2580

gtggccatca acaaccaggc cgccaatacg caggcgcaga ccggactcgt gcacaaccag     2640

ggggtgattc ccggcatggt gtggcagaat agagacgtgt acctgcaggg tcccatctgg     2700

gccaaaattc ctcacacgga cggcaacttt cacccgtctc ccctgatggg cggctttgga     2760

ctgaagcacc cgcctcctca aattctcatc aagaacacac cggttccagc ggacccgccg     2820

cttaccttca accaggccaa gctgaactct ttcatcacgc agtacagcac cggacaggtc     2880

agcgtggaaa tcgagtggga gctgcagaaa gaaaacagca aacgctggaa tccagagatt     2940

caatacactt ccaactacta caaatctaca aatgtggact ttgctgtcaa cacggagggg     3000

gtttatagcg agcctcgccc cattggcacc cgttacctca cccgcaacct gtaattacat     3060

gttaatcaat aaaccggtta attcgtttca gttgaacttt ggtctctgcg aagggcgaat     3120

tc                                                                    3122


<210> 4787
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4787
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Asp Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 4788
<211> 2370
<212> DNA
<213> Adeno-associated virus

<400> 4788
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgca ggaccggatg ttcaagttcg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac caagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gcggagccag caaaagaccc gcccccgatg acgcggatat aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagacgctg tttccctgca      600

aaacgtgcga gagaatgaat cagaatttca acatttgctt cacgcacggg gtcagagact      660

gctcagaatg tttccccggt gcatcagaat ctcaaccggt cgtcagaaaa aaaacgtatc      720

agaaactgtg tgccattcat catctgctgg ggcgggcacc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggacgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggcttgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacctgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca cctcagcgtt cccccgactc ctccacgggc     1320

atcggcaaga aaggccacca gcccgcgaga aagagactga actttgggca gactggcgac     1380

tcggagtcag tccccgaccc tcaaccaatc ggagaaccac cagcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctgcccacct acaacaacca tctctacaag     1620

caaatctcca acgggacatc gggaggaagc actaacgaca acacctactt tggctacagc     1680

accccctggg ggtattttga cttcaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaataa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtgtt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcctccc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tatctgaccc taaacaatgg cagtcaggct gtgggccgtt cctccttcta ctgcctggaa     2040

tacttccctt ctcaaatgct gaggacgggc aacaactttg aattcagcta caccttcgag     2100

gacgtgcctt tccacagcag ctacgcgcac agccagagcc tggaccggct gatgaaccct     2160

ctcatcgacc agtacctgta ttacttatcc agaactcagt ccacaggagg aactcaaggt     2220

actcagcaat tgttattttc tcaagccggg cccgcaaaca tgtyggctca ggccaagaac     2280

tggctacctg gaccgtgtta ccgtcagcaa cgagtttcca cgacactgtc gcaaaacaac     2340

aacagcaatt ttgctggacc ggtgccacca                                      2370


<210> 4789
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4789
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Gly Ala 
            580                 585                 590         


Pro Ile Val Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Val Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4790
<211> 2205
<212> DNA
<213> Adeno-associated virus

<400> 4790
atgactgacg gttaccttcc agattggcta gaggacaacc tctctgaagg cgttcgagag       60

tggtgggcgc tgcaacctgg agcccctaaa cccaaggcaa atcaacaaca tcaggacaac      120

gctcggggtc ttgtgcttcc gggttacaaa tacctcggac ccggcaacgg actcgacaag      180

ggggaacccg tcaacgcagc ggacgcggca gccctcgagc acgacaaggc ctacgaccag      240

cagctcaagg ccggtgacaa cccctacctc aagtacaacc acgccgacgc ggagttccag      300

cagcggcttc agggcgacac atcgtttggg ggcaacctcg gcagagcagt cttccaggcc      360

aaaaagaggg ttcttgaacc tcttggtctg gttgagcaag cgggtgagac ggctcctgga      420

aagaagagac cgttgattga atccccccag cagcccgact cctccacggg tatcggcaaa      480

aaaggcaagc agccggctaa aaagaagctc gttttcgaag acgaaactgg agcaggcgac      540

ggaccccctg agggatcaac ttccggagcc atgtctgatg acagtgagat gcgtgcagca      600

gctggcggag ctgcagtcga gggcggacaa ggtgccgatg gagtgggtaa tgcctcgggt      660

gattggcatt gcgattccac ctggtctgag ggccacgtca cgaccaccag caccagaacc      720

tgggtcttgc ccacctacaa caaccacctc tacaagcgac tcggagagag cctgcagtcc      780

aacacctaca acggattctc caccccctgg ggatactttg acttcaaccg cttccactgc      840

cacttctcac cacgtgactg gcagcgactc atcaacaaca actggggcat gcgacccaaa      900

gccatgcggg tcaaaatctt caacatccag gtcaaggagg tcacgacgtc gaacggcgag      960

acaacggtgg ctaataacct taccagcacg gttcagatct ttgcggactc gtcgtacgaa     1020

ctgccgtacg tgatggatgc gggtcaagag ggcagcctgc ctccttttcc caacgacgtc     1080

tttatggtgc cccagtacgg ctactgtgga ctggtgaccg gcaacacttc gcagcaacag     1140

actgacagaa atgccttcta ctgcctggag tactttcctt cgcagatgct gcggactggc     1200

aacaactttg aaattacgta cagttttgag aaggtgcctt tccactcgat gtacgcgcac     1260

agccagagcc tggaccggct gatgaaccct ctcatcgacc agtacctgtg gggactgcaa     1320

tcgaccacca ccggaaccac cctgaatgcc gggactgcca ccaccaactt taccaagctg     1380

cggcctacca acttttccaa ctttaaaaag aactggctgc ccgggccttc aatcaagcag     1440

cagggcttct caaagactgc caatcaaaac tacaagatcc ctgccaccgg gtcagacagt     1500

ctcatcaaat acgagacgca cagcactctg gacggaagat ggagtgccct gacccccgga     1560

cctccaatgg ccacggctgg acctgcggac agcaagttca gcaacagcca gctcatcttt     1620

gcggggccta aacagaacgg caacacggcc accgtacccg ggactctgat cttcacctct     1680

gaggaggagc tggcagccac caacgccacc gatacggaca tgtggggcaa cctacctggc     1740

ggtgaccaga gcaacagcaa cctgccgacc gtggacagac tgacagcctt gggagccgtg     1800

cctggaatgg tctggcaaaa cagagacatt tactaccagg gtcccatttg ggccaagatt     1860

cctcataccg atggacactt tcacccctca ccgctgattg gtgggtttgg gctgaaacac     1920

ccgcctcctc aaatttttat caagaacacc ccggtacctg cgaatcctgc aacgaccttc     1980

agctctactc cggtaaactc cttcattact cagtacagca ctggccaggt gtcggtgcag     2040

attgactggg agatccagaa ggagcggtcc aaacgctgga accccgaggt ccagtttacc     2100

tccaactacg gacagcaaaa ctctctgttg tgggctcccg atgcggctgg gaaatacact     2160

gagcctaggg ctatcggtac ccgctacctc acccaccacc tgtaa                     2205


<210> 4791
<211> 734
<212> PRT
<213> Adeno-associated virus

<400> 4791
Met Thr Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu 
1               5                   10                  15      


Gly Val Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln 
65                  70                  75                  80  


Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Gln Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Gln Ala Gly Glu Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Leu Ile Glu Ser Pro Gln Gln Pro Asp Ser Ser Thr Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Lys Leu Val Phe Glu Asp Glu Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Thr Ser Gly Ala Met Ser 
            180                 185                 190         


Asp Asp Ser Glu Met Arg Ala Ala Ala Gly Gly Ala Ala Val Glu Gly 
        195                 200                 205             


Gly Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly His Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Arg Leu Gly Glu 
                245                 250                 255     


Ser Leu Gln Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Met Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Leu Val Thr Gly Asn Thr Ser Gln Gln Gln Thr Asp Arg Asn 
    370                 375                 380                 


Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly 
385                 390                 395                 400 


Asn Asn Phe Glu Ile Thr Tyr Ser Phe Glu Lys Val Pro Phe His Ser 
                405                 410                 415     


Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile 
            420                 425                 430         


Asp Gln Tyr Leu Trp Gly Leu Gln Ser Thr Thr Thr Gly Thr Thr Leu 
        435                 440                 445             


Asn Ala Gly Thr Ala Thr Thr Asn Phe Thr Lys Leu Arg Pro Thr Asn 
    450                 455                 460                 


Phe Ser Asn Phe Lys Lys Asn Trp Leu Pro Gly Pro Ser Ile Lys Gln 
465                 470                 475                 480 


Gln Gly Phe Ser Lys Thr Ala Asn Gln Asn Tyr Lys Ile Pro Ala Thr 
                485                 490                 495     


Gly Ser Asp Ser Leu Ile Lys Tyr Glu Thr His Ser Thr Leu Asp Gly 
            500                 505                 510         


Arg Trp Ser Ala Leu Thr Pro Gly Pro Pro Met Ala Thr Ala Gly Pro 
        515                 520                 525             


Ala Asp Ser Lys Phe Ser Asn Ser Gln Leu Ile Phe Ala Gly Pro Lys 
    530                 535                 540                 


Gln Asn Gly Asn Thr Ala Thr Val Pro Gly Thr Leu Ile Phe Thr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Ala Ala Thr Asn Ala Thr Asp Thr Asp Met Trp Gly 
                565                 570                 575     


Asn Leu Pro Gly Gly Asp Gln Ser Asn Ser Asn Leu Pro Thr Val Asp 
            580                 585                 590         


Arg Leu Thr Ala Leu Gly Ala Val Pro Gly Met Val Trp Gln Asn Arg 
        595                 600                 605             


Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Ala Thr Thr Phe Ser Ser Thr Pro Val Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Gln Ile Asp Trp Glu Ile Gln Lys Glu 
        675                 680                 685             


Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly 
    690                 695                 700                 


Gln Gln Asn Ser Leu Leu Trp Ala Pro Asp Ala Ala Gly Lys Tyr Thr 
705                 710                 715                 720 


Glu Pro Arg Ala Ile Gly Thr Arg Tyr Leu Thr His His Leu 
                725                 730                 


<210> 4792
<211> 3128
<212> DNA
<213> Adeno-associated virus

<400> 4792
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatgttgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaaag tgcgcgtgga ccaaaagtgc aagccgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgcg ggaccggatg ttcaagtttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcagagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca cgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

aaacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaaa aagacgtatc      720

ggaaactctg tgcgattcat catctgctgg ggcgggcacc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctagatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca ccccagcgtt ctccagactc ctctacgggc     1320

atcggcaaga aaggccagca gcccgcgaaa aagagactca actttgggca gactggcgac     1380

tcagagtcag tgcccgaccc tcaaccaatc ggagaacccc ccgcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctccccacct acaacaacca cctctacaag     1620

caaatctcca acgggacttc gggaggaagc accaacgaca acacctactt cggctacagc     1680

accccctggg ggtattttga ctttaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaacaa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtctt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tacctgactc tgaacaatgg cagtcaggcc gtgggccgtt cctccttcta ctgcctggag     2040

tactttcctt ctcaaatgct gagaacgggc aacaactttg agttcagcta ccagtttgag     2100

gacgtgcctt ttcacagcag ctacgcgcac agccaaagcc tggaccggct gatgaacccc     2160

ctcatcgacc agtacctgta ctacctgtct cggactcagt ccacgggagg taccgcagga     2220

actcagcagt tgctattttc tcaggccggg cctaataaca tgtcggctca ggccaaaaac     2280

tggctacccg ggccctgcta ccggcagcaa cgcgtctcca cgacactgtc gcaaaataac     2340

aacagcaact gtaaatcccg gtgtcgctat ggcaacccac aaggacgacg aagagcgatt     2400

ttgcctggac cggtgccacc aagtatcatc tgaatggcag agactctctg ttttccgtcc     2460

agcggagtct taatgtttgg gaaacaggga gctggaaaag acaacgtgga ctatagcagc     2520

gttatgctaa ccagtgagga agaaattaaa accaccaacc cagtggccac ggaacagtac     2580

ggcgtggtgg ccgataacct gcaacagcaa aacgccgctc ctattgtagg ggccgtcaac     2640

agtcaaggag ccttacctgg catggtctgg cagaaccggg acgtgtacct gcagggtcct     2700

atctgggcca agattcctca cacggacgga aactttcatc cctcgccgct gatgggaggc     2760

tttggactga aacacccgcc tcctcagatc ctgattaaga atacacctgt tcccgcggat     2820

cctccaacta ccttcagtca agctaagctg gcgtcgttca tcacgcagta cagcaccgga     2880

caggtcagcg tggaaattga atgggagctg cagaaagaaa acagcaaacg ctggaaccca     2940

gagattcaat acacttccaa ctactacaaa tctacaaatg tggacttcgc tgttaacaca     3000

gatggcactt attctgagcc tcgccccatt ggcacccgtt acctcacccg taatctgtaa     3060

ttgctcgtta atcaataaac cggttgattc gtttcagttg aactttggtc tctgcgaagg     3120

gcgaattc                                                              3128


<210> 4793
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4793
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4794
<211> 3129
<212> DNA
<213> Adeno-associated virus

<400> 4794
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaaag tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgca ggaccggatg ttcaagtttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcagagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca cgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

aaacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaaa aagacgtatc      720

ggaaactctg tgcgattcat catctgctgg gggcgggcac ccgagattgc ttgctcggcc      780

tgcgatctgg tcaacgtgga cctagatgac tgtgtttctg agcaataaat gacttaaacc      840

aggtatggct gccgatggtt atcttccaga ttggctcgag gacaacctct ctgagggcat      900

tcgcgagtgg tgggacttga aacctggagc cccgaaaccc aaagccaacc agcaaaagca      960

ggacgacggc cggggtctgg tgcttcctgg ctacaagtac ctcggaccct tcaacggact     1020

cgacaagggg gagcccgtca acgcggcgga cgcagcggcc ctcgagcacg acaaggccta     1080

cgaccagcag ctcaaagcgg gtgacaatcc gtacctgcgg tataaccacg ccgacgccga     1140

gtttcaggag cgtctgcaag aagatacgtc ttttgggggc aacctcgggc gagcagtctt     1200

ccaggccaag aagcgggttc tcgaacctct cggtctggtt gaggaaggcg ctaagacggc     1260

tcctggaaag aagagaccgg tagagccatc accccagcgt tctccagact cctctacggg     1320

catcggcaag aaaggccagc agcccgcgaa aaagagactc aactttgggc agactggcga     1380

ctcagagtca gtgcccgacc ctcaaccaat cggagaaccc cccgcaggcc cctctggtct     1440

gggatctggt acaatggctg caggcggtgg cgctccaatg gcagacaata acgaaggcgc     1500

cgacggagtg ggtagttcct caggaaattg gcattgcgat tccacatggc tgggcgacag     1560

agtcatcacc accagcaccc gaacctgggc cctccccacc tacaacaacc acctctacaa     1620

gcaaatctcc aacgggactt cgggaggaag caccaacgac aacacctact tcggctacag     1680

caccccctgg gggtattttg actttaacag attccactgc cacttctcac cacgtgactg     1740

gcagcgactc atcaacaaca actggggatt ccggcccaag agactcaact tcaagctctt     1800

caacatccag gtcaaggagg tcacgcagaa tgaaggcacc aagaccatcg ccaataacct     1860

taccagcacg attcaggtct ttacggactc ggaataccag ctcccgtacg tcctcggctc     1920

tgcgcaccag ggctgcctgc ctccgttccc ggcggacgtc ttcatgattc ctcagtacgg     1980

gtacctgact ctgaacaatg gcagtcaggc cgtgggccgt tcctccttct actgcctgga     2040

gtactttcct tctcaaatgc tgagaacggg caacaacttt gagttcagct accagtttga     2100

ggacgtgcct tttcacagca gctacgcgca cagccaaagc ctggaccggc tgatgaaccc     2160

cctcatcgac cagtacctgt actacctgtc tcggactcag tccacgggag gtaccgcagg     2220

aactcagcag ttgctatttt ctcaggccgg gcctaataac atgtcggctc aggccaaaaa     2280

ctggctaccc gggccctgct accggcagca acgcgtctcc acgacactgt cgcaaaataa     2340

caacagcaac tttgcctgga ccggtgccac caagtatcat ctgaatggca gagactctct     2400

ggtaaatccc ggtgtcgcta tggcaaccca caaggacgac gaagagcgat tttttccgtc     2460

cagcggagtc ttaatgtttg ggaaacaggg agctggaaaa gacaacgtgg actatagcag     2520

cgttatgcta accagtgagg aagaaattaa aaccaccaac ccagtggcca cagaacagta     2580

cggcgtggtg gccgataacc tgcaacagca aaacgccgct cctattgtag gggccgtcaa     2640

cagtcaagga gccttacctg gcatggtctg gcagaaccgg gacgtgtacc tgcagggtcc     2700

tatctgggcc aagattcctc acacggacgg aaactttcat ccctcgccgc tgatgggagg     2760

ctttggactg aaacacccgc ctcctcagat cctgattaag aatacacctg ttcccgcgga     2820

tcctccaact accttcagtc aagctaagct ggcgtcgttc atcacgcagt acagcaccgg     2880

acaggtcagc gtggaaattg aatgggagct gcagaaagaa aacagcaaac gctggaaccc     2940

agagattcaa tacacttcca actactacaa atctacaaat gtggactttg ctgttaacac     3000

agatggcact tattctgagc ctcgccccat cggcacccgt tacctcaccc gtaatctgta     3060

attgcttgtt aatcaataaa ccggttgatt cgtttcagtt gaactttggt ctctgcgaag     3120

ggcgaattc                                                             3129


<210> 4795
<211> 3128
<212> DNA
<213> Adeno-associated virus

<400> 4795
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaaag tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgca ggaccggatg ttcaagtttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcagagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca cgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

aaacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt tgtcagaaaa aagacgtatc      720

ggaaactctg tgcgattcat catctgctgg ggcgggcacc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctagatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca ccccagcgtt ctccagactc ctctacgggc     1320

atcggcaaga aaggccagca gcccgcgaaa aagagactca actttgggca gactggcgac     1380

tcagagtcag tgcccgaccc tcaaccaatc ggagaacccc ccgcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctccccacct acaacaacca cctctacaag     1620

caaatctcca acgggacttc gggaggaagc accaacgaca acacctactt cggctacagc     1680

accccctggg ggtattttga ctttaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaacaa ctggggattc cggcccaaga gacccaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtctt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tacctgactc tgaacaatgg cagtcaggcc gtgggccgtt cctccttcta ctgcctggag     2040

tactttcctt ctcaaatgct gagaacgggc aacaactttg agttcagcta ccagtttgag     2100

gacgtgcctt ttcacagcag ctacgcgcac agccaaagcc tggaccggct gatgaacccc     2160

ctcatcgacc agtacctgta ctacctgtct cggactcagt ccacgggagg taccgcagga     2220

actcagcagt tgctattttc tcaggccggg cctaataaca tgtcggctca ggccaaaaac     2280

tggctacccg ggccctgcta ccggcagcaa cgcgtctcca cgacactgtc gcaaaataac     2340

aacagcaact ttgcctggac cggtgccacc aagtatcatc tgaatggcag agactctctg     2400

gtaaatcccg gtgtcgctat ggcaacccac aaggacgacg aagagcgatt ttttccgtcc     2460

agcggagtct taatgtttgg gaaacaggga gctggaaaag acaacgtgga ctatagcagc     2520

gttatgctaa ccagtgagga agaaattaaa accaccaacc cagtggccac agaacagtac     2580

ggcgtggtgg ccgataacct gcaacagcaa aacgccgctc ctattgtagg ggccgtcaac     2640

agtcaaggag ccttacctgg catggtctgg cagaaccggg acgtgtacct gcagggtcct     2700

atctgggcca agattcctca cacggacgga aactttcatc cctcgccgct gatgggaggc     2760

tttggactga aacacccgcc tcctcagatc ctgattaaga atacacctgt tcccgcggat     2820

cctccaacta ccttcagtca agctaagctg gcgtcgttca tcacgcagta cagcaccgga     2880

caggtcagcg tggaaattga atgggagctg cagaaagaaa acagcaaacg ctggaaccca     2940

gagattcaat acacttccaa ctactacaaa tctacaaatg tggactttgc tgttaacaca     3000

gatggcactt attctgagcc tcgccccatt ggcacccgtt acctcacccg taatctgtaa     3060

ttgcttgtta atcaataaac cggttgattc gtttcagttg aactttggtc tctgcgaagg     3120

gcgaattc                                                              3128


<210> 4796
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4796
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Pro Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4797
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4797
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4798
<211> 720
<212> PRT
<213> Adeno-associated virus

<400> 4798
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


<210> 4799
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4799
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4800
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4800
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4801
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4801
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4802
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4802
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4803
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4803
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Gly Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Arg Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Asn Gly Gln 
145                 150                 155                 160 


Pro Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asp Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4804
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 4804
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaagcacag gcgcagaccg gctgggttca aaaccaagga     1800

atacttccgg gtatggtttg gcaggacaga gatgtgtacc tgcaaggacc catttgggcc     1860

aaaattcctc acacggacgg caactttcac ccttctccgc tgatgggagg gtttggaatg     1920

aagcacccgc ctcctcagat cctcatcaaa aacacacctg tacctgcgga tcctccaacg     1980

gccttcaaca aggacaagct gaactctttc atcacccagt attctactgg ccaagtcagc     2040

gtggagatcg agtgggagct gcagaaggaa aacagcaagc gctggaaccc ggagatccag     2100

tacacttcca actattacaa gtctaataat gttgaatttg ctgttaatac tgaaggtgta     2160

tatagtgaac cccgccccat tggcaccaga tacctgactc gtaatctgta a              2211


<210> 4805
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4805
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 4806
<211> 2460
<212> DNA
<213> Adeno-associated virus

<400> 4806
ggtaattcct ccggaaattg gcattgcgat tccacatggc tgggcgaccg agtcattacc       60

accagcaccc ggacttgggc cctgcccacc tacaacaacc acctctacaa gcaaatctcc      120

agccaatcgg gtgccaccaa cgacaaccac tacttcggct acagcacccc ttgggggtat      180

tttgatttca acagattcca ctgccatttc tcaccacgtg actggcagcg actcatcaac      240

aacaactggg gattcatggc tgccgatggt tatcttccag attggctcga ggacactctc      300

tctgaaggaa tcagacagtg gtggaagctc aaacctggcc caccaccgcc gaaacctaac      360

caacaacacc gggacgacag taggggtctt gtgcttcctg ggtacaagta cctcggaccc      420

ttcaacggac tcgacaaagg agagccggtc aacgaggcag acgccgcggc cctcgagcac      480

gacaaagcct acgaccacca gctcaagcaa ggggacaacc cgtacctcaa atacaaccac      540

gcggacgctg aatttcagga gcgtcttcaa gaagatacgt ctttcggggg caacctcggg      600

cgagcagtct tccaggccaa aaagagggta ctcgagcctc ttggtctggt tgaggaagct      660

gttaagacgg ctcctggaaa aaagagacct atagagcagt ctcctgcaga accggactct      720

tcctcgggca tcggcaaatc aggccagcag cccgctaaga aaagactcaa ttttggtcag      780

actggcgaca cagagtcagt cccagaccct caaccaatcg gagaaccccc cgcagccccc      840

tctggtgtgg gatctaatac aatggcttca ggcggtgggg caccaatggc agacaataac      900

gaaggcgccg acggagtggg taattcctcg ggaaattggc attgcgattc cacatggatg      960

ggcgacagag ttatcaccac cagcacaaga acctgggccc tccccaccta caataatcac     1020

ctctacaagc aaatctccag cgaatcggga gccaccaacg acaaccacta cttcggctac     1080

agcaccccct gggggtattt tgactttaac agattccact gtcacttctc accacgtgac     1140

tggcagcgac tcatcaacaa caactgggga tttagaccca agaaactcaa tttcaagctc     1200

ttcaacatcc aagtcaagga ggtcacgcag aatgatggaa ccacgaccat cgccaataac     1260

cttaccagca cggtgcaggt cttcacagac tctgagtacc agctgcccta cgtcctcggt     1320

tcggctcacc agggctgcct tccgccgttc ccagcagacg tcttcatgat tcctcagtac     1380

ggctacttga ctctgaacaa tggcagccaa gcggtaggac gttcttcatt ctactgtcta     1440

gagtattttc cctctcagat gctgaggacg ggaaacaact tcaccttcag ctacactttt     1500

gaagacgtgc ctttccacag cagctacgcg cacagccaga gtctggatcg gctgatgaat     1560

cctctcattg accagtacct gtattacctg agcaaaactc agggtacaag tggaacaacg     1620

cagcaatcga gactgcagtt cagccaagct gggcctagct ccatggctca gcaggccaaa     1680

aactggctac cgggacccag ctaccgacag cagcgaatgt ctaagacggc taatgacaac     1740

aacaacagtg aatttgcttg gactgcagcc accaaatatt acctgaatgg aagaaattct     1800

ctggtcaatc ccgggccccc aatggccagt cacaaggacg atgaggaaaa gtatttcccc     1860

atgcacggaa atctcatctt tggaaaacaa ggcacaggaa ctaccaatgt ggacattgaa     1920

tcagtgctta ttacagacga agaagaaatc agaacaacta atcctgtggc tacagaacaa     1980

tacggacagg ttgccaccaa ccatcagagt cagaacacca cagcttccta tggaagtgtg     2040

gacagccagg gaatcttacc tggaatggtg tggcaggacc gcgatgtcta tcttcaaggt     2100

cccatttggg ccaaaactcc tcacacggac ggacactttc atccttctcc gctcatggga     2160

ggctttggac tgaaacaccc tcctccccag atcctgatca aaaacacacc tgtgccagcg     2220

aatcccgcga ccactttcac tcctggaaag tttgcttcgt tcattaccca gtattccacc     2280

ggacaggtca gcgtggaaat agagtgggag ctgcagaaag aaaacagcaa acgctggaac     2340

ccagaaattc agtacacctc caactacaac aagtcggtga atgtggagtt taccgtggac     2400

gcaaacggtg tttattctga accccgccct attggcactc gttaccttac ccggaacttg     2460


<210> 4807
<211> 3123
<212> DNA
<213> Adeno-associated virus

<400> 4807
gaattcgccc tttctacggc tgcgtcaact ggaccaatga aaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggaaagat gaccgccaag gtcgtggaat      120

ctgccaaagc cattctgggt ggaggcaagg ttcgtgtgga ccagaaatgc aagtcttcgg      180

cccagatcga cccgactccg gtgattgtca cctctaacac caacatgtgc gccgtgattg      240

acggaaactc gaccaccttc gagcaccagc agccgttgca agaccggatg ttcaaatttg      300

aacttacccg ccgtttggat catgactttg ggaaggtcac caagcaggaa gtcaaagact      360

ttttccggtg ggctcaagat cacgtgactg aggtggagca tgagttctac gtcaaaaagg      420

gtggagccaa gaaaaggccc gcccccgatg atgtatatat aaatgagccc aagcgggcgc      480

gcgagtcagt tgcgcagcca tcgacgtcag acgcggaagc ttcgataaac tacgcggaca      540

ggtaccaaaa caaatgttct cgtcacgtgg gcatgaatct gatgctgttt ccctgtcgac      600

aatgcgaaag aatgaatcag aattcaaata tctgcttcac acacgggcaa aaagactgtt      660

tggaatgctt tcccgtgtca gaatctcaac ccgtttctgt cgtcagaaaa acgtatcaga      720

aactttgtta cattcatcat atcatgggaa aagtaccaga cgcctgcact gcctgcgacc      780

tggtaaatgt ggacttggat gactgtattt ctgagcaata aatgacttaa atcaggtatg      840

gctgctgacg gttatcttcc agattggctc gaggacactc tctctgaagg aatcagacag      900

tggtggaagc tcaaacctgg cccaccaccg ccgaaaccta accaacaaca ccgggacgac      960

agtaggggtc ttgtgcttcc tgggtacaag tacctcggac ccttcaacgg actcgacaaa     1020

ggagagccgg tcaacgaggc agacgccgcg gccctcgagc acgacaaagc ctacgaccac     1080

cagctcaagc aaggggacaa cccgtacctc aaatacaacc acgcggacgc tgaatttcag     1140

gagcgtcttc aagaagatac gtctttcggg ggcaacctcg ggcgagcagt cttccaggcc     1200

aaaaagaggg tactcgagcc tcttggtctg gttgaggaag ctgttaagac ggctcctgga     1260

aaaaagagac ctatagagca gtctcctgca gaaccggact cttcctcggg catcggcaaa     1320

tcaggccagc agcccgctaa gaaaagactc aattttggtc agactggcga cacagagtca     1380

gtcccaggcc ctcaaccaat cggagaaccc cccgcagccc cctctggtgt gggatctaat     1440

acaatggctt caggcggtgg ggcaccaatg gcagacaata acgaaggcgc cgacggagtg     1500

ggtaattcct cgggaaattg gcattgcgat tccacatgga tgggcgacag agttatcacc     1560

accagcacaa gaacctgggc cctccccacc tacaataatc acctctacaa gcaaatctcc     1620

agcgaatcgg gagccaccaa cgacaaccac tacttcggct acagcacccc ctgggggtat     1680

tttgacttta acagattcca ctgtcacttc tcaccacgtg actggcagcg actcatcaac     1740

aacaactggg gatttagacc caagaaactc aatttcaagc tcttcaacat ccaagtcaag     1800

gaggtcacgc agaatgatgg aaccacgacc atcgccaata accttaccag cgcggtgcag     1860

gtcttcacag actctgagta ccagctgccc tacgtcctcg gttcggctca ccagggctgc     1920

cttccgccgt tcccagcaga cgtcttcatg attcctcagt acggctactt gactctgaac     1980

aatggcagcc aagcggtagg acgttcttca ttctactgtc tagagtattt tccctctcag     2040

atgctgagga cgggaaacaa cttcaccttc agctacactt ttgaagacgt gcctttccac     2100

agcagctacg cgcacagcca gagtctggat cggctgatga atcctctcat tgaccagtac     2160

ctgtattacc tgagcaaaac tcagggtaca agtggaacaa cgcagcaatc gagactgcag     2220

ttcagccaag ctgggcctag ctccatggct cagcaggcca aaaactggct accgggaccc     2280

agctaccgac agcagcgaat gtctaagacg gctaatgaca acaacaacag tgaatttgct     2340

tggactgcag ccaccaaata ttacctgaat ggaagaaatt ctctggtcaa tcccgggccc     2400

ccagtggcca gtcacaagga cgatgaggaa aagtatttcc ccatgcacgg aaatctcatc     2460

tttggaaaac aaggcacagg aactaccaat gtggacattg aatcagtgct tattacagac     2520

gaagaagaaa tcagaacaac taatcctgtg gctacagaac aatacggaca ggttgccacc     2580

aaccatcaga gtcagaacac cacagcttcc tatggaagtg tggacagcca gggaatctta     2640

cctggaatgg tgtggcagga ccgcgatgtc tatcttcaag gtcccatttg ggccaaaact     2700

cctcacacgg acggacactt tcatccttct ccgctcatgg gaggctttgg actgaaacac     2760

cctcctcccc agatcctgat caaaaacaca cctgtgccag cgaatcccgc gaccactttc     2820

actcctggaa agtttgcttc gttcattacc cagtattcca cctgacaggt cagcgtggaa     2880

atagagtggg agctgcagaa agaaaacagc aaacgctgga acccagaaat tcagtacacc     2940

tccaactaca acaagtcggt gaatgtggag tttaccgtgg acgcaaacgg tgtttattct     3000

gaaccccgcc ctattggcac tcgttacctt acccggaact tgtaatttcc tgttaatgaa     3060

taagccgatt tatgcgtttc agttgaactt tggtctctgc gaagggcgaa ttcgtttaaa     3120

cct                                                                   3123


<210> 4808
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4808
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Asn Gln Gln His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


His Gln Leu Lys Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Gln Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Gly Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Glu Ser Gly Ala Thr Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Ala Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Gln Gly Thr Ser Gly Thr Thr Gln Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Ser Ser Met Ala Gln Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Met Ser Lys Thr Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Thr Ala Ala Thr Lys Tyr Tyr Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Val Asn Pro Gly Pro Pro Val Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Met His Gly Asn Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Thr Thr Asn Val Asp Ile Glu Ser Val Leu Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ser Gln Asn Thr Thr Ala Ser Tyr 
            580                 585                 590         


Gly Ser Val Asp Ser Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Thr Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ala Thr Thr Phe Thr Pro Gly Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Glu Phe Thr Val Asp Ala Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4809
<211> 3123
<212> DNA
<213> Adeno-associated virus

<400> 4809
gaattcgccc tttctacggc tgcgtcaact ggaccaatga aaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggaaagat gaccgccaag gtcgtggaat      120

ctgccaaagc cattctgggt ggaagcaagg ttcgtgtgga ccagaaatgc aagtcttcgg      180

cccagatcga cccgactccg gtgattgtca cctctaacac caacatgtgc gccgtgattg      240

acggaaactc gaccaccttc gagcaccagc agccgttgca agaccggatg ttcaaatttg      300

aacttacccg ccgtttggat catgactttg ggaaggtcac caagcaggaa gtcaaagact      360

ttttccggtg ggctcaagat cacgtgactg aggtggagca tgagttctac gtcaaaaagg      420

gtggagccaa gaaaaggccc gcccccgatg atgtatatat aaatgagccc aagcgggcgc      480

gcgagtcagt tgcgcagcca tcgacgtcag acgcggaagc ttcgataaac tacgcgggca      540

ggtaccaaaa caaatgttct cgtcacgtgg gcatgaatct gatgctgttt ccctgtcgac      600

aatgcgaaag aatgaatcag aattcaaata tctgcttcac acacgggcaa aaagactgtt      660

tggaatgctt tcccgtgtca gaatctcaac ccgtttctgt cgtcagaaaa acgtatcaga      720

aactttgtta cattcatcat atcatgggaa aagaaccaga cgcctgcact gcctgcgacc      780

tggtaaatgt ggacttggat gactgtattt ctgagcaata aatgacttaa atcaggtatg      840

gctgctgacg gttatcttcc agattggctc gaggacactc tctctgaagg aatcagacag      900

tggtggaagc tcaaacctgg cccaccaccg ccgaaaccta accaacaaca ccgggacgac      960

agtaggggtc ttgtgcttcc tgggtacaag tacctcggac ccttcaacgg actcgacaaa     1020

ggagagccgg tcaacgaggc agacgccgcg gccctcgagc acgacaaagc ctacgaccac     1080

cagctcaagc aaggggacaa cccgtacctc aaatacaacc acgcggacgc tgaatttcag     1140

gagcgtcttc aagaagatac gtctttcggg ggcaacctcg ggcgagcagt cttccaggcc     1200

aaaaagaggg tactcgagcc tcttggtctg gttgaggaag ctgttaagac ggctcctgga     1260

aaaaagagac ctatagagca gtctcctgca gaaccggact cttcctcggg catcggcgaa     1320

tcaggccagc agcccgctaa gaaaagactc aattttggtc agactggcga cacagagtca     1380

gtcccagacc ctcaaccaat cggagaaccc cccgcagccc cctctggtgt gggatctaat     1440

acaatggctt caggcggtgg ggcaccaatg gcagacgata acgaaggcgc cgacggagtg     1500

ggtaattcct cgggaaattg gcattgcgat tccacatgga tgggcgacag agttatcacc     1560

accagcacaa gaacctgggc cctccccacc tacaataatc acctctacaa gcaaatctcc     1620

agcgaatcgg gagccaccaa cgacaaccac tacttcggct acagcacccc ctgggggtat     1680

tttgacttta acagattcca ctgtcacttc tcaccacgtg actggcagcg actcatcaac     1740

aacaactggg gatttagacc caagaaactc aatttcaagc tcttcaacat ccaagtcaag     1800

gaggtcacgc agaatgatgg aaccacgacc atcgccaata accttaccag cacggtgcag     1860

gtcttcacag actctgagta ccagctgccc tacgtcctcg gttcggctca ccagggctgc     1920

cttccgccgt tcccagcaga cgtcttcatg attcctcagt acggctactt gactctgaac     1980

aatggcagcc aagcggtagg acgttcttca ttctactgtc tagagtattt tccctctcag     2040

atgctgagga cgggaaacaa cttcaccttc agctacactt ttgaagacgt gcctttccac     2100

agcagctacg cgcacagcca gagtctggat cggctgatga atcctctcat tgaccagtac     2160

ctgtattacc tgagcaaaac tcagggtaca agtggaacaa cgcagcaatc gagactgcag     2220

ttcagccaag ctgggcctag ctccatggct cagcaggcca aaaactggct accgggaccc     2280

agctaccgac agcagcgaat gtctaagacg gctaatgaca acaacaacag tgaatttgct     2340

tggactgcag ccaccaaata ttacctgaat ggaagaaatt ctctggtcaa tcccgggccc     2400

ccaatggcca gtcacaagga cgatgaggaa aagtatttcc ccatgcacgg aaatctcatc     2460

tttggaaaac aaggcacagg aactaccaat gtggacattg aatcagtgct tattacagac     2520

gaagaagaaa tcagaacaac taatcctgtg gctacagaac aatacggaca ggttgccacc     2580

aaccatcaga gtcaggacac cacagcttcc tatggaagtg tggacagcca gggaatctta     2640

cctggaatgg tgtggcagga ccgcgatgtc tatcttcaag gtcccatttg ggccaaaact     2700

cctcacacgg acggacactt tcatccttct ccgctcatgg gaggctttgg actgaaacac     2760

cctcctcccc agatcctgat caaaaacaca cctgtgccag cgaatcccgc gaccactttc     2820

actcctggaa agtttgcttc gttcattacc cagtattcca ccggacaggt cagcgtggaa     2880

atagagtggg agctgcagaa agaaaacagc aaacgctgga acccagaaat tcagtacacc     2940

tccaactaca acaagtcggt gaatgtggag tttaccgtgg acgcaaacgg tgtttattct     3000

gaaccccgcc ctattggcac tcgttacctt acccggaact tgtaatttcc tgttaatgaa     3060

taaaccgatt tatgcgtttc agttgaactt tggtctctgc gaagggcgaa ttcgcggccg     3120

cta                                                                   3123


<210> 4810
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4810
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Asn Gln Gln His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


His Gln Leu Lys Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Gln Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Glu Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asp Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Glu Ser Gly Ala Thr Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Gln Gly Thr Ser Gly Thr Thr Gln Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Ser Ser Met Ala Gln Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Met Ser Lys Thr Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Thr Ala Ala Thr Lys Tyr Tyr Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Val Asn Pro Gly Pro Pro Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Met His Gly Asn Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Thr Thr Asn Val Asp Ile Glu Ser Val Leu Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ser Gln Asp Thr Thr Ala Ser Tyr 
            580                 585                 590         


Gly Ser Val Asp Ser Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Thr Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ala Thr Thr Phe Thr Pro Gly Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Glu Phe Thr Val Asp Ala Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4811
<211> 3113
<212> DNA
<213> Adeno-associated virus

<400> 4811
gaattcgccc tttctacggc tgcgtcaact ggaccaatga aaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggaaagat gaccgccaag gtcgtggaat      120

ctgccaaagc cattctgggt ggaagcaagg ttcgtgtgga ccagaaatgc aagtcttcgg      180

cccagatcga cccgactccg gtgattgtca cctctaacac caacatgtgc gccgtgattg      240

acggaaactc gaccaccttc gagcaccagc agccgttgca agaccggatg ttcaaatttg      300

aacttacccg ccgtttggat catgactttg ggaaggtcac caagcaggaa gtcaaagact      360

ttttccggtg ggctcaagat cacgtgactg aggtggagca tgagttctac gtcaaaaagg      420

gtggagccaa gaaaaggccc gcccccgatg atgtatatat aaatgagccc aagcgggcgc      480

gcgagtcagt tgcgcagcca tcgacgtcag acgcggaagc ttcgataaac tacgcggaca      540

ggtaccaaaa caaatgttct cgtcacgtgg gcatgaatct gatgctgttt ccctgtcgac      600

aatgcgaaag aatgaatcag aattcaaata tctgcttcac acacgggcaa aaagactgtt      660

tggaatgctt tcccgtgtca gaatctcaac ccgttcctgt cgtcagaaaa acgtatcaga      720

aactttgtta cattcatcat atcatgggaa aagtaccaga cgcctgcact gcctgcgacc      780

tggtaaatgt ggacttggat gactgtattt ctgagcaata aatgacttaa atcaggtatg      840

gctgctgacg gttatcttcc agattggctc gaggacactc tctctgaagg aatcagacag      900

tggtggaagc tcaaacctgg cccaccaccg ccgaaaccta accaacaaca ccgggacgac      960

agtaggggtc ttgtgcttcc tgggtacaag tacctcggac ccttcaacgg actcgacaaa     1020

ggagagccgg tcaacgaggc agacgccgcg gccctcgagc acgacaaagc ctacgaccac     1080

cagctcaagc aaggggacaa cccgtacctc aaatacaacc acgcggacgc tgaatttcag     1140

gagcgtcttc aagaagatac gtctttcggg ggcaacctcg ggcgagcagt cttccaggcc     1200

aaaaagaggg tactcgagcc tcttggtctg gttgaggaag ctgttaagac ggctcctgga     1260

aaaaagagac ctatagagca gtctcctgca gaaccggact cttcctcggg catcggcaaa     1320

tcaggccagc agcccgctaa gaaaagactc aattttggtc agactggcga cacagagtca     1380

gtcccagacc ctcaaccaat cggagaaccc cccgcagccc cctctggtgt gggatctaat     1440

acaatggctt caggcggtgg ggcaccaatg gcagacaata acgaaggcgc cgacggagtg     1500

ggtaattcct cgggaaattg gcattgcgat tccacatgga tgggcgacag agttatcacc     1560

accagcacaa gaacctgggc cctccccacc tacaataatc acctctacaa gcaaatctcc     1620

agcgaatcgg gagccaccaa cgacaaccac tacttcggct acagcacccc ctgggggtat     1680

tttgacttta acagattcca ctgtcacttc tcaccacgtg actggcagcg actcatcaat     1740

aacaactggg gatttagacc caagaaactc aatttcaagc tcttcaacat ccaagtcaag     1800

gaggtcacgc agaatgatgg aaccacgacc atcgccaata accttaccag cacggtgcag     1860

gtcttcacag actctgagta ccagctgccc tacgtcctcg gttcggctca ccagggctgc     1920

cttccgccgt tcccagcaga cgtcttcatg attcctcagt acggctactt gactctgaac     1980

aatggcagcc aagcggtagg acgttcttca ttctactgtc tagagtattt tccctctcag     2040

atgctgagga cgggaaacaa cttcaccttc agctacactt ttgaagacgt gcctttccac     2100

agcagctacg cgcacagcca gagtctggat cggctgatga atcctctcat tgaccagtac     2160

ctgtattacc tgagcaaaac tcagggtaca agtggaacaa cgcagcaatc gagactgcag     2220

ttcaaccaag ctgggcctag ctccatggct cagcaggcca aaaactggct accgggaccc     2280

agctaccgac agcagcgaat gtctaagacg gctaatgaca acaacaacag tgaatttgct     2340

tggactgcag ccaccaaata ttacccgaat ggaagaaatt ctctggtcaa tcccgggccc     2400

ccaatggcca gtcacaagga cgatgaggaa aagtatttcc ccatgcacgg aaatctcatc     2460

tttggaaaac aaggcacagg aactaccaat gtggacattg aatcagtgct tattacagac     2520

gaagaagaaa tcagaacgac taatcctgtg gctacagaac aatacggaca ggttgccacc     2580

aaccgtcaga gtcagaacac cacagcttcc tatggaagtg tggacagcca gggaatctta     2640

cctggaatgg tgtggcagga ccgcgatgtc tatcttcaag gtcccatttg ggccaaaact     2700

cctcacacgg acggacactt tcatccttct ccgctcatgg gaggctttgg actgaaacac     2760

cctcctcccc agatcctgat caaaaacaca cctgtgccag cgaatcccgc gaccactttc     2820

actcctggaa agtttgcttc gttcattacc cagtattcca ccggacaggt cagcgtggaa     2880

atagagtggg agctgcagaa agaaaacagc aaacgctgga acccggaaat tcagtacacc     2940

tccaactaca acaagtcggt gaatgtggag tttaccgtgg acgcaaacgg tgtttattct     3000

gaaccccgcc ctattggcac tcgttacctt acccggaact tgtaatttcc tgttaatgaa     3060

taaaccgatt tatgcgtttc agttgaactt tggtctctgc gaagggcgaa ttc            3113


<210> 4812
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4812
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Asn Gln Gln His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


His Gln Leu Lys Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Gln Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Glu Ser Gly Ala Thr Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Gln Gly Thr Ser Gly Thr Thr Gln Gln Ser Arg Leu Gln Phe Asn Gln 
    450                 455                 460                 


Ala Gly Pro Ser Ser Met Ala Gln Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Met Ser Lys Thr Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Thr Ala Ala Thr Lys Tyr Tyr Pro Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Val Asn Pro Gly Pro Pro Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Met His Gly Asn Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Thr Thr Asn Val Asp Ile Glu Ser Val Leu Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn Arg Gln Ser Gln Asn Thr Thr Ala Ser Tyr 
            580                 585                 590         


Gly Ser Val Asp Ser Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Thr Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ala Thr Thr Phe Thr Pro Gly Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Glu Phe Thr Val Asp Ala Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4813
<211> 3122
<212> DNA
<213> Adeno-associated virus

<400> 4813
agcggccgcg aattcgccct ttctacggct gcgtcaactg gaccaatgaa aactttccct       60

tcaacgattg cgtcgacaag atggtgatct ggtgggagga gggaaagatg accgccaagg      120

tcgtggaatc tgccaaagcc attctgggtg gaagcaaggt tcgtgtggac cagaaatgca      180

ggtcttcggc ccagatcgac ccgactccgg tgattgtcac ctctaacacc aacatgtgcg      240

ccgtgattga cggaaactcg accaccttcg agcaccagca gccgttgcaa gaccggatgt      300

tcaaatttga acttacccgc cgtttggatc atgactttgg gaaggtcacc aagcaggaag      360

tcaaagactt tttccggtgg gctcaagatc acgtgactga ggtggagcat gagttctacg      420

tcaaaaaggg tggagccaag aaaaggcccg cccccgatga tgtatatata aatgagccca      480

agcgggcgcg cgagtcagtt gcgcagccat cgacgtcaga cgcggaagct tcgataaact      540

acgcggacag gtaccaaaac aaatgttctc gtcacgtggg catgaatctg atgctgtttc      600

cctgtcgaca atgcgaaaga atgaatcaga attcaaatat ctgcttcaca cacgggcaaa      660

aagactgttt ggaatgcttt cccgtgtcag aatctcaacc cgtttctgtc gtcagaaaaa      720

cgtatcagaa actttgttac attcatcata tcatgggaaa agtaccagac gcctgcactg      780

cctgcgacct ggtaaatgtg gacttggatg actgtatttc tgagcaataa atgacttaaa      840

tcaggtatgg ctgctgacgg ttatcttcca gattggctcg aggacactct ctctgaagga      900

atcagacagt ggtggaagct caaacctggc ccaccaccgc cgaaacctaa ccaacaacac      960

cgggacgaca gtaggggtct tgtgcttcct gggtacaagt acctcggacc cttcaacgga     1020

ctcgacaaag gagagccggt caacgaggca gacgccgcgg ccctcgagca cgacaaagcc     1080

tacgaccacc agctcaagca aggggacaac ccgtacctca aatacaacca cgcggacgct     1140

gaatttcagg agcgtcttca agaagatacg tctttcgggg gcaacctcgg gcgagcagtc     1200

ttccaggcca aaaagagggt actcgagcct cttggtctgg ttgaggaagc tgttaagacg     1260

gctcctggaa aaaagagacc tatagagcag tctcctgcag aaccggactc ttcctcgggc     1320

atcggcaaat caggccagca gcccgctaag aaaagactca attttggtca gactggcgac     1380

acagagtcag tcccagaccc tcaaccaatc ggagaacccc ccgcagcccc ctctggtgtg     1440

ggatctaata caatggcttc aggcggtggg gcaccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtaattcctc gggaaattgg cattgcgatt ccacatggat gggcgacaga     1560

gttatcacca ccagcacaag aacctgggcc ctccccacct acaataatcg cctctacaag     1620

caaatctcca gcgaatcggg agccaccaac gacaaccact acttcggcta cagcaccccc     1680

tgggggtatt ttgactttaa cagattccac tgtcacttct caccacgtga ctggcagcga     1740

ctcatcaaca acaactgggg atttagaccc aagaaactca atttcaagct cttcaacatc     1800

caagtcaagg aggtcacgca gaatgatgga accacgacca tcgccaataa ccttaccagc     1860

acggtgcagg tcttcacaga ctctgagtac cagctgccct acgtcctcgg ttcggctcac     1920

cagggctgcc ttccgccgtt cccagcagac gtcttcatga ttcctcagta cggctacttg     1980

actctgaaca atggcagcca agcggtagga cgttcttcat tctactgtct agagtatttt     2040

ccctctcaga tgctgaggac gggaaacaac ttcaccttca gctacacttt tgaagacgtg     2100

cctttccaca gcagctacgc gcacagccag agtctggatc ggctgatgaa tcctctcatt     2160

gaccagtacc tgtattacct gagcaaaact cagggtacaa gtggaacaac gcagcaatcg     2220

agactgcagt tcagccaagc tgggcctagc tccatggctc agcaggccaa aaactggcta     2280

ccgggaccca gctaccgaca gcagcgaatg tctaagacgg ctaatgacaa caacaacagt     2340

gaatttgctt ggactgcagc caccaaatat tacctgaatg gaagaaattc tctggtcaat     2400

cccgggcccc caatggccag tcacaaggac gatgaggaaa agtatttccc catgcacgga     2460

aatctcatct ttggaaaaca aggcacagga actaccaatg tggacattga atcagtgctt     2520

attacagacg aagaagaaat cagaacaact aatcctgtgg ctacagaaca atacggacag     2580

gttgccacca accatcagag tcagaacacc acagcttcct atggaagtgt ggacagccag     2640

ggaatcttac ctggaatggt gtggcaggac cgcgatgtct atcttcaagg tcccatttgg     2700

gccaaaactc ctcacacgga cggacacttt catccttctc cgctcatggg aggctttgga     2760

ctgaaacacc ctcctcccca gatcctgatc aaaaacacac ctgtgccagc gaatcccgcg     2820

accactttca ctcctggaaa gtttgcttcg ttcattaccc agtattccac cggacaggtc     2880

agcgtggaaa tagagtggga gctgcagaaa gaaaacagca aacgctggaa cccagaaatt     2940

cagtacacct ccaactacaa caagtcggtg aatgtggagt ttaccgtgga cgcaaacggt     3000

gtttattctg aaccccgccc tattggcact cgttacctta cccggaactt gtaatttcct     3060

gttaatgaat aaaccgattt atgcgtttca gttgaacttt ggtctctgcg aagggcgaat     3120

tc                                                                    3122


<210> 4814
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4814
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Asn Gln Gln His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


His Gln Leu Lys Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Gln Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn Arg Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Glu Ser Gly Ala Thr Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Gln Gly Thr Ser Gly Thr Thr Gln Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Ser Ser Met Ala Gln Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Met Ser Lys Thr Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Thr Ala Ala Thr Lys Tyr Tyr Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Val Asn Pro Gly Pro Pro Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Met His Gly Asn Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Thr Thr Asn Val Asp Ile Glu Ser Val Leu Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ser Gln Asn Thr Thr Ala Ser Tyr 
            580                 585                 590         


Gly Ser Val Asp Ser Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Thr Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ala Thr Thr Phe Thr Pro Gly Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Glu Phe Thr Val Asp Ala Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4815
<211> 733
<212> PRT
<213> Adeno-associated virus

<400> 4815
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Arg Leu Asn Phe Glu Glu Asp Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Asp Thr Ser Ala Met Ser 
            180                 185                 190         


Ser Asp Ile Glu Met Arg Ala Ala Pro Gly Gly Asn Ala Val Asp Ala 
        195                 200                 205             


Gly Gln Gly Ser Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly Lys Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu Gly Thr 
                245                 250                 255     


Thr Ser Asn Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Leu Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Ser Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Ile Val Thr Gly Glu Asn Gln Asn Gln Thr Asp Arg Asn Ala 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Met Ala Tyr Asn Phe Gly Lys Val Pro Phe His Ser Met 
                405                 410                 415     


Tyr Ala Tyr Ser Gln Ser Pro Asp Arg Leu Met Asn Pro Leu Leu Asp 
            420                 425                 430         


Gln Tyr Leu Trp His Leu Gln Ser Thr Thr Ser Gly Glu Thr Leu Asn 
        435                 440                 445             


Gln Gly Asn Ala Ala Thr Thr Phe Gly Lys Ile Arg Ser Gly Asp Phe 
    450                 455                 460                 


Ala Phe Tyr Arg Lys Asn Trp Leu Pro Gly Pro Cys Val Lys Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro Ala Ser Gly 
                485                 490                 495     


Gly Asn Ala Leu Leu Lys Tyr Asp Thr His Tyr Thr Leu Asn Asn Arg 
            500                 505                 510         


Trp Ser Asn Ile Ala Pro Gly Pro Pro Met Ala Thr Ala Gly Pro Ser 
        515                 520                 525             


Asp Gly Asp Phe Ser Asn Ala Gln Leu Ile Phe Pro Gly Pro Ser Val 
    530                 535                 540                 


Thr Gly Asn Thr Thr Thr Ser Ala Asn Asn Leu Leu Phe Thr Ser Glu 
545                 550                 555                 560 


Glu Glu Ile Ala Ala Thr Asn Pro Arg Asp Thr Asp Met Phe Gly Gln 
                565                 570                 575     


Ile Ala Asp Asn Asn Gln Asn Ala Thr Thr Ala Pro Ile Thr Gly Asn 
            580                 585                 590         


Val Thr Ala Met Gly Val Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Ala Asp Gly 
    610                 615                 620                 


His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ala 
                645                 650                 655     


Thr Thr Phe Thr Ala Ala Arg Val Asp Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ala Val Gln Ile Glu Trp Glu Ile Glu Lys Glu Arg 
        675                 680                 685             


Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly Asn 
    690                 695                 700                 


Gln Ser Ser Met Leu Trp Ala Pro Asp Thr Thr Gly Lys Tyr Thr Glu 
705                 710                 715                 720 


Pro Arg Val Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730             


<210> 4816
<211> 733
<212> PRT
<213> Adeno-associated virus

<400> 4816
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Leu 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe His Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Arg Leu Asn Phe Glu Glu Asp Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Asp Thr Ser Ala Met Ser 
            180                 185                 190         


Ser Asp Ile Glu Met Arg Ala Ala Pro Gly Gly Asn Ala Val Asp Ala 
        195                 200                 205             


Gly Gln Gly Ser Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly Lys Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu Gly Thr 
                245                 250                 255     


Thr Ser Asn Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Leu Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Ile Val Thr Gly Glu Asn Gln Asn Gln Thr Asp Arg Asn Ala 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Met Ala Tyr Asn Phe Glu Lys Val Pro Phe His Ser Met 
                405                 410                 415     


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Leu Asp 
            420                 425                 430         


Gln Tyr Leu Trp His Leu Gln Ser Thr Thr Ser Gly Glu Thr Leu Asn 
        435                 440                 445             


Gln Gly Asn Ala Ala Thr Thr Phe Gly Lys Ile Arg Ser Gly Asp Phe 
    450                 455                 460                 


Ala Phe Tyr Arg Lys Asn Trp Leu Pro Gly Pro Cys Val Lys Gln Gln 
465                 470                 475                 480 


Arg Phe Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro Ala Ser Gly 
                485                 490                 495     


Gly Asn Ala Leu Leu Lys Tyr Asp Thr His Tyr Thr Leu Asn Asn Arg 
            500                 505                 510         


Trp Ser Asn Ile Ala Pro Gly Pro Pro Met Ala Thr Ala Gly Pro Ser 
        515                 520                 525             


Asp Gly Asp Phe Ser Asn Ala Gln Leu Ile Phe Pro Gly Pro Ser Val 
    530                 535                 540                 


Thr Gly Asn Thr Thr Thr Ser Ala Asn Asn Leu Leu Phe Thr Ser Glu 
545                 550                 555                 560 


Gly Glu Ile Ala Ala Thr Asn Pro Arg Asp Thr Asp Met Phe Gly Gln 
                565                 570                 575     


Ile Ala Asp Asn Asn Gln Asn Ala Thr Thr Ala Pro Ile Thr Gly Asn 
            580                 585                 590         


Val Thr Ala Met Gly Val Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Ala Asp Gly 
    610                 615                 620                 


His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ala 
                645                 650                 655     


Thr Thr Phe Thr Ala Ala Arg Val Asp Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ala Val Gln Ile Glu Trp Glu Ile Glu Lys Glu Arg 
        675                 680                 685             


Ser Lys Arg Arg Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly Asn 
    690                 695                 700                 


Gln Ser Ser Met Leu Trp Ala Pro Asp Thr Thr Gly Lys Tyr Thr Glu 
705                 710                 715                 720 


Pro Arg Val Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730             


<210> 4817
<211> 733
<212> PRT
<213> Adeno-associated virus

<400> 4817
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Glu Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Arg Leu Asn Phe Glu Glu Asp Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Asp Thr Ser Ala Met Ser 
            180                 185                 190         


Ser Asp Ile Glu Met Arg Ala Ala Pro Gly Gly Asn Ala Val Asp Ala 
        195                 200                 205             


Gly Gln Gly Ser Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly Lys Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu Gly Thr 
                245                 250                 255     


Thr Ser Asn Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Leu Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Ile Val Thr Gly Glu Asn Gln Asn Gln Thr Asp Arg Asn Ala 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Thr Ala Tyr Asn Phe Glu Lys Val Pro Phe His Ser Met 
                405                 410                 415     


Tyr Ala His Ser Gln Ser Leu Asp Gly Leu Met Asn Pro Leu Leu Asp 
            420                 425                 430         


Gln Tyr Leu Trp His Leu Gln Ser Thr Thr Ser Gly Glu Thr Leu Asn 
        435                 440                 445             


Gln Gly Asn Ala Ala Thr Thr Phe Gly Lys Ile Arg Ser Gly Asp Phe 
    450                 455                 460                 


Ala Phe Tyr Arg Lys Asn Trp Leu Pro Gly Pro Cys Val Lys Gln Gln 
465                 470                 475                 480 


Arg Phe Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro Ala Ser Gly 
                485                 490                 495     


Gly Asn Ala Leu Leu Lys Tyr Asp Thr His Tyr Thr Leu Asn Asn Arg 
            500                 505                 510         


Trp Ser Asn Ile Ala Pro Gly Pro Pro Met Ala Thr Ala Gly Pro Ser 
        515                 520                 525             


Asp Gly Asp Phe Ser Asn Ala Gln Leu Ile Phe Pro Gly Pro Ser Val 
    530                 535                 540                 


Thr Gly Asn Thr Thr Thr Ser Ala Asn Asn Leu Leu Phe Thr Ser Glu 
545                 550                 555                 560 


Glu Glu Ile Ala Ala Thr Asn Pro Arg Asp Thr Asp Met Phe Gly Gln 
                565                 570                 575     


Ile Ala Asp Asn Asn Gln Asn Ala Thr Thr Ala Pro Ile Thr Gly Asn 
            580                 585                 590         


Val Thr Ala Met Gly Val Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Ala Asp Gly 
    610                 615                 620                 


His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Tyr Pro Ala 
                645                 650                 655     


Thr Thr Phe Thr Ala Ala Arg Val Asp Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ala Val Gln Ile Glu Trp Glu Ile Glu Lys Glu Arg 
        675                 680                 685             


Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Cys Gly Asn 
    690                 695                 700                 


Gln Ser Ser Met Leu Trp Ala Pro Asp Thr Thr Gly Lys Tyr Thr Glu 
705                 710                 715                 720 


Pro Arg Val Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730             


<210> 4818
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4818
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Asn Gln Gln His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


His Gln Leu Lys Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Gln Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Glu Ser Gly Ala Thr Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Gln Gly Thr Ser Gly Thr Thr Gln Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Ser Ser Met Ala Gln Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Met Ser Lys Thr Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Thr Ala Ala Thr Lys Tyr Tyr Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Val Asn Pro Gly Pro Pro Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Met His Gly Asn Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Thr Thr Asn Val Asp Ile Glu Ser Val Leu Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ser Gln Asn Thr Thr Ala Ser Tyr 
            580                 585                 590         


Gly Ser Val Asp Ser Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ala Thr Thr Phe Thr Pro Gly Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Glu Phe Thr Val Asp Ala Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4819
<211> 3127
<212> DNA
<213> Adeno-associated virus

<400> 4819
gcggccgcga attcgccctt cgcagagacc aaagttcaac tgaaacgaat caaccggttt       60

attgattaac atgcaattac agattacggg tgaggtaacg agtgccaata gggcgaggct      120

cagagtaaac accctggctg tcaacggcaa agtccacacc agtctgcttt tcaaagttgg      180

aggtgtactg aatctccggg tcccagcgct tgctgttttc cttctgcagc tcccactcga      240

tttccacgct gacttgtccg gtgctgtact gtgtgatgaa cgaagcaaac ttggcaggag      300

taaacacctc cggaggatta gcgggaacgg gagtgttctt gatcaggatc tgaggaggcg      360

gatgtttaag tccaaagccg cccatcaaag gagacgggtg aaagttgcca tccgtgtgag      420

gaatcttggc ccagatggga ccctgcaggt acacgtcccg gttctgccag accatgccag      480

gtaaggctcc ctggttgttg acaacttgtg tctgggctgc agtattagcc gcttgtaagt      540

tgctgctgac tatcccgtat tcttccgtgg ctacaggatt agtaggacga atttcttctt      600

catttgtcat taacacattt tccaatgtag ttttgttagt tgctccagtt tttccaaaaa      660

tcaggactcc gctggatggg aaaaagcggt cctcgtcgtc cttgtgagtt gccatggcga      720

cgccgggatt aaccaacgag tttctgccgt tcaggtgata tttggtggca ccagtccaag      780

caaagttgct gttgttgttt tgatccagcg ttttggagac cctttgttgc cggaagcagg      840

gtccaggtaa ccaattcttg gcttgttcgg ccatagttga aggcccgccc tggtaaaact      900

gcagttcccg attgccagct gtgcctcctg ggtcactctg tgttctggcc aggtagtaca      960

agtactggtc gatgagggga ttcatcagcc ggtccaggct ctggctgtgt gcgtagctgc     1020

tgtggaaagg cacgtcctcg aagctgtagc tgaactcaaa gttgttgccc gttctcagca     1080

tctgagaggg gaagtactcc aggcagtaga aggaggaacg tcccacagac tgactgccat     1140

tgttgagagt caggtagccg tactgaggaa tcatgaagac gtccgccggg aacggaggca     1200

ggcagccctg gtgcgcagag ccgaggacgt acggcagctg gtattccgag tccgagaata     1260

cctgaatcgt gctggtaagg ttattagcga tggtcgtaac gccgtcattc gtcgtgacct     1320

ccttgacctg gatgttgaag agcttgaacc gcagcttctt gggccggaat ccccagttgt     1380

tgttgatgag tcgctgccag tcacgtggtg agaagtggca gtggaatctg ttaaagtcaa     1440

aataccccca gggggtgctg tagccgaagt aggtgttgtc gttggtacta cctgcagttt     1500

cactggagat ttgctcgtag aggtggttgt tgtaggtggg cagggcccag gttcgggtgc     1560

tggtggtaat gactctgtcg cccagccatg tggaatcgca atgccaattt cctgaggcat     1620

tacccactcc gtcggcacct tcgttattgt ctgccattgg tgcgccaccg cctgcagcca     1680

ctgtaccaga tcccacacta gagggcgctg ctggaggttc tccgagaggt tgagggtcgg     1740

ggactgactc tgagtcgcca gtctgaccga aattgagtct ctttctggcg ggctgctggc     1800

ccttcttgcc gatgcccgtg gaggagtcgg gggaacgctg aggtgacggc tctaccggtc     1860

tcttctttgc aggagccgtc ttagcgcctt cctcaaccag accgagaggt tcgagaaccc     1920

gcttcttggc ctggaagact gctcgcccga ggttgccccc aaatgacgta tcttcttgca     1980

gacgctcctg aaactcggcg tcggcgtggt tataccgcag gtacgggttg tcacccgcat     2040

tgagctgctg gtcgtaggcc ttgtcgtgct cgagggccgc tgcgtccgcc gcgttgacgg     2100

gctccccctt gtcgagtccg ttgaagggtc cgaggtactt gtagccagga agcaccagac     2160

cccggccgtt gtcctgcttt tgctggttgg ctttgggttt cggggctcca ggtttcaggt     2220

cccaccactc gcgaatgccc tcagagaggt tgtcctcgag ccaatctgga agataaccat     2280

cggcagccat acctgattta aatcatttat tgttcaaaga tgcagtcatc caaatccaca     2340

ttgaccagat cgcaggcagt gcaagcgtct ggcacctttc ccatgatatg atgaatgtag     2400

cacagtttct gatacgcctt tttgacgaca gaaacgggtt tagattctga cacgggaaag     2460

cactctaaac agtctttctg tccgtgagtg aagcagatat ttgaattctg attcattctc     2520

tcgcattgtc tgcagggaaa cagcatcaga ttcatgccca cgtgacgaga acatttgttt     2580

tggtacctgt ctgcgtagtt gatcgaagct tccgcgtctg acgtcgatgg ctgcgcaact     2640

gactcgcgca cccgtttggg ctcacttata tctgcgtcac tgggggcggg tcttttcttg     2700

gctccaccct ttttgacgta gaattcatgc tccacctcaa ccacgtaatc ctttgcccac     2760

cggaaaaagt ctttgacttc ctgcttggtg accttcccaa agtcatgatc cagacggcgg     2820

gtgagttcaa atttgaacat ccggtcttgc aacggctgct ggtgttcgaa ggtcgttgag     2880

ttcccgtcga tcacggcgca catgttggtg ttggagatga cgatcgcggg agtcgggtct     2940

atctgggccg aggacttgca tttctggtcc acgcgcacct tgcttcctcc gagaatggct     3000

ttggccgact ccacgacctt ggcggtcatc ttcccctcct cccaccagat caccatcttg     3060

tcgacacagt cgttgaaggg aaagttctca ttggtccagt tgacgcagcc gtagaaaggg     3120

cgaattc                                                               3127


<210> 4820
<211> 3106
<212> DNA
<213> Adeno-associated virus

<400> 4820
gcggccgcga attcgccctt cgcagagacc aaagttcaac tgaaacgaat caaccggttt       60

attgattaac aagtaattac aggttacggg tgaggtaacg ggtgccaatg gggcgaggct      120

cagtataaac cccttcgttg ttgacagcaa attccacatt attagacttg gcataatttg      180

aggtgtactg aatctctgga ttccagcgtt tgctgttttc tttctgcagt tcccactcga      240

tctccacgct gacctggccg gtgctgtact gcgtgataaa tgaggcaaac ttggcaggag      300

taaacacctc tggaggatta gcaggtaccg gggtgttttt gatgagaatt tgaggaggcg      360

ggtgtttgag tccaaatccg cccatcaggg gagacgggtg aaagttgccg tccgtgtgag      420

gaattttggc ccagatggga ccctgcaggc acacgtcccg gttctgccag accatgccgg      480

gcagagcccc ctggctgttg acagtctgtg tctggggtcc ggccgtagac gattgcaggt      540

tgctggagac cacaccgtat tcttctgtag ccacgggatt ggtggttttg atctcctcct      600

cgctggtcat tagcacgttt tccagcgttg tcttgttggc agcccccgtt ttgccaaaaa      660

ccagcactcc gttgatggga aagaactggt cctcgtcgtc cttgttggtg gccatggcta      720

cgcccgggtt ggttaatgaa tttctaccat tcagatggta tttagtggcc ccggtccagg      780

caaagttact gttgttgttg ctgtctatgt tttttgacag tctctgctgc cgataacagg      840

gtccgggcag ccagttcttt gattgctcgg ccatggtgtt gggcccagcc tgatggaact      900

gcagctccct tgtggacccc gtagtgctct gggtccgggc caggtagtac aggtactggt      960

cgatgagggg attcatcagc cggtctaggc tctggctgtg cacatagctg ctgtggaaag     1020

gcacttcctc aaaggtgtag ctgaattcaa agttattgcc cgttctcagc atctgagaag     1080

gaaagtactc caggcagtag aaggaggaac gtcccacaga ctgactgccg ttgtttagag     1140

tcagatatcc gtactgagga atcatgaaca cgtccgcagg gaacggaggg aggcagccct     1200

ggtgcgcaga gccgaggacg tacggcagtt ggtactccga gtccgagaag acctgaatcg     1260

tgctggtaag gttattagcg atggtcgtaa cgccgtcgtt cgtcgtgacc tccttgacct     1320

ggatgttgaa caacttgaac cgcagctttc tgggccggaa tccccagttg ttgttgatga     1380

gtcgctgcca gtcacgtggt gagaagtggc agtggaatct gttgaagtca aaatagcccc     1440

agggggtgct gtagctgaag aagtggttgt cgttggtagc cccgctctga cttgatatct     1500

gcttgtagag gtggttgttg taggtgggca gggcccaggt gcgggtgctg gtggtgatga     1560

ctctgtcgcc cagccatgtg gaatcgcaat gccaatttcc ggaggcatta cccactccgt     1620

cggcgccttc gttattgtct gccattggtg cgccaccgcc tgcagccatt gtaccagatc     1680

ccagacctga gggcgcggcg ggaggttctc cgagaggttg ggggtcgggc actgactctg     1740

agtcgccagt ctgcccaaag ttgagcttct ttttagcggg ctgctggcct ttcttgccga     1800

tgcccgtgga ggagtcgggg gattctatgg gtctcttctt tccaggagcc gtcttagcga     1860

cttcctcaac cagaccgaga ggttcgagaa cccgcttctt ggcctggaag actgctcgcc     1920

cgaggttgcc cccaaaagac gtatcttctt gaagacgctc ctgaaactcg gcgtcggcgt     1980

ggttgtactt gaggtacggg ttgtccccct gctcgagctg cttgtcgtag gccttgtcgt     2040

gctcgagggc cgcggcgtct gcctcgttga ccggctctcc cttgtcgagt ccgttgaagg     2100

gtctgaggta cttgtagcca ggaagcacca gaccccggcc gtcgtcctgc ttttgctggt     2160

tggctttggg tttcggggct ccaggtttca agtcccacca ctcgcgaatg ccctcagaga     2220

ggttgtcctc gagccaatct ggaagataac catcggcagc catacctggt ttaagtcatt     2280

tattgctcag aaacacagtc atccaggtcc acgttgacca gatcgcaggc cgagcaagca     2340

atctcgggag cccgccccag cagatgatga atggcacaga gtttccgata cgtcctcttt     2400

ctgacgaccg gttgagattc tgacacgccg gggaaacatt ctgaacagtc tctggtcccg     2460

tgcgtgaagc aaatgttgaa attctgattc actctctcgc atgtcttgca gggaaacagc     2520

atctgaagca tgcccgcgtg acgagaacat ttgttttggt acctgtcggc aaagtccacc     2580

ggagctcctt ccgcgtctga cgtcgatgga ttcgcgactg aggggcaggc ccgcttgggc     2640

tcgcttttat ccgcgtcatc gggggcgggt ctcttgttgg ccccaccctt tctgacgtag     2700

aacccatgcg ccacctcggt cacgtgatcc tgcgcccagc ggaagaacct tttgacttcc     2760

tgctttgtca ccttgccaaa gttatgctcc agacggcggg tgggttcaaa tttgaacatc     2820

cggtcctgca acggctgctg gtgctcgaag gtggcgctgt tcccgtcaat cacggcgcac     2880

atgttggtgt tggaggtgac ggtcacgggg gtggggtcga tctgggcgga cgacttgcac     2940

ttttggtcca cgcgcacctt gctgccgccg agaatggcct tggcggactc cacgaccttg     3000

gccgtcatct tgccctcctc ccaccagatc accatcttgt cggcgcaatc gttgaaggga     3060

aagttctcat tggtccagtt gacgcagccg tagaaagggc gaattc                    3106


<210> 4821
<211> 3102
<212> DNA
<213> Adeno-associated virus

<400> 4821
gcggccgcga attcgccctt cgcagagacc aaagttcaac tgaaacgaat caaccggttt       60

attgattaac aagtaattac aggttacggg tgaggtaacg ggtgccaatg gggcgaggct      120

cagtataaac cccttcgttg ttgacagcaa attccacatt attagacttg gcataatttg      180

aggtgtactg aatctctgga ttccagcgtt tgctgttttc tttctgcagt tcccactcga      240

tctccacgct gacctggccg gtgctgtact gcgtgataaa tgaggcaaac ttggcaggag      300

taaacacctc tggaggatta gcaggtaccg gggtgttttt gatgagaatt tgaggaggcg      360

ggtgtttgag tccaaatccg cccatcaggg gagacgggtg aaagttgccg tccgtgtgag      420

gaatttcggc ccagatggga ccctgcaggt acacgtcccg gttctgccag accatgccgg      480

gcagagcccc ctggctgttg acagtctgtg tccggggtcc ggccgtagac gattgcaggt      540

tgctggagac cacaccgtat tcttctgtag ccacgggatt ggtggttttg atctcctcct      600

cgctggtcat tagcacgttt tccagcgttg tcttgttggc agcccccgtt ttgccaaaaa      660

ccagcactcc gttgatggga aggaactggt cctcgtcgtc cttgttggtg gccatggcta      720

cgcccgggtt ggttaatgaa tttctaccat tcagatggta tttagtggcc ccggtccagg      780

caaagttact gttgttgttg ctgtctatgt tttttgacag tctctgctgc cgataacagg      840

gtccgggcag ccagttcttt gattgctcgg ccacggtgtt gggcccagcc tgatggaact      900

gcagctccct tgtggacccc gtagtgctct gggtccgggc caggtagtac aggtactggt      960

cgatgagggg attcatcagc cggtccaggc tctggctgtg cgcatagctg ctgtggaaag     1020

gcacttcctc aaaggtgtag ctgaattcaa agttattgcc cgttctcagc atctgagaag     1080

gaaagtactc caggcagcag aaggaggaac gtcccacaga ctgactgccg ttgtttagag     1140

tcagatatcc gtactgagga atcatgaaca cgtccgcagg gaacggaggg aggcagccct     1200

ggtgcgcaga gccgaggacg tacggcagtt ggtactccga gtccgagaag acctgaatcg     1260

tgctggtaag gttattagcg atggtcgtaa cgccgtcgtt cgtcgtgacc tccttgacct     1320

ggatgttgaa caacttgaac cgcagctttc tgggccggaa tccccagttg ttgttgatga     1380

gtcgctgcca gtcacgtggt gagaagtggc agtggaatct gttgaagtca aaatagcccc     1440

agggggtgct gtagccgaag aagtggttgt cgttggtagc cccgctctga cttgatatct     1500

gcttgtagag gtggttgttg taggtgggca gggcccaggt gcgggtgctg gtggtgatga     1560

ctctgtcgcc cagccatgtg gaatcgcaat gccaatttcc ggaggcatta cccactccgt     1620

cggcgccttc gttattgtct gccattggtg cgccaccgcc tgcagccatt gtaccagatc     1680

ccagacctga gggcgcggcg ggaggttctc cgagaggttg ggggtcgggc actgactctg     1740

agtcgccagt ctgcccaaag ttgagcttct ttttagcggg ctgctggcct ttcttgccga     1800

tgcccgtgga ggagtcgggg gattctatgg gtctcttctt tccggaagcc gtcttagcgc     1860

cttcctcaac cagaccgaga ggttcgagaa cccgcttctt ggcctggaag actgctcgcc     1920

cgaggttgcc cccaaaagac gtatcttctt gaagacgctc ctgaaactcg gcgtcggcgt     1980

ggttgtactt gaggtacggg ttgtccccct gctcgagctg cttgtcgtag gccttgtcgt     2040

gctcgagggc cgcggcgtct gcctcgttga ccggctctcc cttgtcgagt ccgttgaagg     2100

gtccgaggta cttgtagcca ggaagcacca gaccccggcc gtcgtcctgc ttttgctggt     2160

tggctttggg tttcggggct ccaggtttca agtcccacca ctcgcgaatg ccctcagaga     2220

ggttgtcctc gagccaatct ggaagataac catcggcagc catacctggt ttaagtcatt     2280

tattgctcag aaacacagtc atccaggtcc acgttgacca gatcgcaggc cgagcaagca     2340

atctcgggag cccgccccag cagatgatga atggcacaga gtttccgata cgtcctcttt     2400

ctgacgaccg gttgagattc tgacacgccg gggaaacatt ctgaacagtc tctggtcccg     2460

tgcgtgaagc aaatgttgaa attctgattc attctctcgc atgtcttgca gggaaacagc     2520

atctgaagca tgcccgcgtg acgagaacat ttgttttggt acctgtcggc aaagtccacc     2580

ggagctcctt ccgcgtctga cgtcgatgga tccgcgactg aggggcaagc ccgcttgggc     2640

tcgcttttat ccgcgtcatc gggggcgggt ctcttgttgg ctccaccctt tctgacgtag     2700

aactcatgcg ccacctcggt cacgtgatcc tgcgcccagc ggaagaactc tttgacttcc     2760

tgctttgtca ccttgccaaa gtcatgctcc agacggcggg tgagttcaaa tttgaacatc     2820

cggtcttgta acggctgctg gtgctcgaag gtggtgctgt tcccgtcaat cacggcgcac     2880

atgttggtgt tggaagtgac gatcacgggg gtgggatcga tctgggcgga cgacttgcac     2940

ttttggtcca cgcgcacctt gctgccgccg agaatggcct tggcggactc cacgaccttg     3000

gccgtcatct tgccctcctc ccaccagatc accatcttgt cgacgcaatc gttgaaggga     3060

aagttctcat tggtccagtt gacgcagccg aagggcgaat tc                        3102


<210> 4822
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4822
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Arg Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Asn Gly Gln 
145                 150                 155                 160 


Pro Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4823
<211> 2187
<212> DNA
<213> Adeno-associated virus

<400> 4823
atggctgccg atggttatct tccagattgg ctcgagggca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aggtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

aagcagctcg agcaggggga caacccgtac ctcaagtaca accacgccga cgccgagttt      300

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gacccataga atcccccgac tcctccacgg gcatcggcaa gaacggccag      480

ccgcccgcta aaaagaagct caactttggg cagactggcg actcagagtc agtgcccgac      540

ccccaacctc tcggagaacc tcccgccgcg ccctcaggtc tgggatctgg tacaatggct      600

gcaggcggtg gcgcaccaat ggcagacaat aacgaaggcg ccgacggagt gggtaatgcc      660

tccggaaatt ggcattgcga ttccacatgg ctgggcgaca gagtcatcac caccagcacc      720

cgcacctggg ccctgcccac ctacaacaac cacctctaca agcagatatc aagtcagagc      780

ggggctacca acgacaacca cttcttcggc tacagcaccc cctggggcta ttttgacttc      840

aacagattcc actgccactt ctcaccacgt gactggcagc gactcatcaa caacaactgg      900

ggattccggc ccagaaagct gcggttcaag ttgttcaaca tccaggtcaa ggaggtcacg      960

acgaacgacg gcgttacgac catcgctaat aaccttacca gcacgattca ggtcttctcg     1020

gactcggagt accaactgcc gtacgtcctc ggctctgcgc accagggctg cctccctccg     1080

ttccctgcgg acgtgttcat gattcctcag tacggatatc tgactctaaa caacggcagt     1140

cagtctgtgg gacgttcctc cttctactgc ctggagtact ttccttctca gatgctgaga     1200

acgggcgata actttgaatt cagctacacc tttgaggaag tgcctttcca cagcagctat     1260

gcgcacagcc agagcctgga ccggctgatg aatcccctca tcgaccagta cctgtactac     1320

ctggcccgga cccagagcac tacggggtcc acaagggagc tgcagttcca tcaggctggg     1380

cccaacacca tggccgagca atcaaagaac tggctgcccg gaccctgtta tcggcagcag     1440

agactgtcaa aaaacataga cagcaacaac aacagtaact ttgcctggac cggggccact     1500

aaataccatc tgaatggtag aaattcatta accaacccgg gcgtagccat ggccaccaac     1560

aaggacgacg aggaccagtt ctttcccatc aacggagtgc tggtttttgg caaaacgggg     1620

gctgccaaca agacaacgct ggaaaacgtg ctaatgacca gcgaggagga gatcaaaacc     1680

accaatcccg tggctacaga agaatacggt gtggtctcca gcaacctgca atcgtctacg     1740

gccggacccc agacacagac tgtcaacagc cagggggctc tgcccggcat ggtctggcag     1800

aaccgggacg tgtacctgca gggtcccatc tgggccaaaa ttcctcacac ggacggcaac     1860

tttcacccgt ctcccctgat gggcggattt ggactcaaac acccgcctcc tcaaattctc     1920

atcaaaaaca ccccggtacc tgctaatcct ccagaggtgt ttactcctgc caagtttgcc     1980

tcatttatca cgcagtacag caccggccag gtcagcgtgg agatcgagtg ggaactgcag     2040

aaagaaaaca gcaaacgctg gaatccagag attcagtaca cctcaaatta tgccaagtct     2100

aataatgtgg aatttgctgt caacaacgaa ggggtttata ctgagcctcg ccccattggc     2160

acccgttacc tcacccgtaa cctgtaa                                         2187


<210> 4824
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4824
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Gly Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Arg Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Asn Gly Gln 
145                 150                 155                 160 


Pro Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asp Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4825
<211> 3106
<212> DNA
<213> Adeno-associated virus

<400> 4825
gcggccgcga attcgccctt cgcagagacc aaagttcaac tgaaacgaat cagccggttt       60

attgattaac aagtaattac aggttacggg tgaggtaacg ggtgccaatg gggcgaggct      120

cagtataaac cccttcgttg ttgacagcaa attccacatt attagacttg gcataatttg      180

aggtgtactg aatctctgga ttccagcgtt tgctgttttc tttctgcagt tcccactcga      240

tctccacgct gacctggccg gtgctgtact gcgtgataaa tgaggcaaac ttggcaggag      300

taaacacctc tggaggatta gcaggtaccg gggtgttttt gatgagaatt tgaggaggcg      360

ggtgtttgag tccaaatccg cccatcaggg gagacgggtg aaagttgccg tccgtgtgag      420

gaattttggc ccagatggga ccctgcaggt acacgtcccg gttctgccag accatgccgg      480

gcagagcccc ctggctgttg acagtctgtg tctggggtcc ggccgtagac gattgcaggt      540

tgctggagac cacaccgtat tcttctgtag ccacgggatt ggtggttttg atctcctcct      600

cgctggtcat tagcacgttt tccagcgttg tcttgttggc agcccccgtt ttgccaaaaa      660

ccagcactcc gttgatggga aagaactggt cctcgtcgtc cttgttggtg gccatggcta      720

cgcccgggtt ggttaatgaa tttctaccat tcagatggta tttagtggcc ccggtccagg      780

caaagttact gttgttgttg ctgtctatgt tttttgacag tctctgctgc cgataacagg      840

gtccgggcag ccagttcttt gattgctcgg ccatggtgtt gggcccagcc tgatggaact      900

gcagctccct tgtggacccc gtagtgctct gggtccgggc caggtagtac aggtactggt      960

cgatgagggg attcatcagc cggtccaggc tctggctgtg cgcatagctg ctgtggaaag     1020

gcacttcctc aaaggtgtag ctgaattcaa agttatcgcc cgttctcagc atctgagaag     1080

gaaagtactc caggcagtag aaggaggaac gtcccacaga ctgactgccg ttgtttagag     1140

tcagatatcc gtactgagga atcatgaaca cgtccgcagg gaacggaggg aggcagccct     1200

ggtgcgcaga gccgaggacg tacggcagtt ggtactccga gtccgagaag acctgaatcg     1260

tgctggtaag gttattagcg atggtcgtaa cgccgtcgtt cgtcgtgacc tccttgacct     1320

ggatgttgaa caacttgaac cgcagctttc tgggccggaa tccccagttg ttgttgatga     1380

gtcgctgcca gtcacgtggt gagaagtggc agtggaatct gttgaagtca aaatagcccc     1440

agggggtgct gtagccgaag aagtggttgt cgttggtagc cccgctctga cttgatatct     1500

gcttgtagag gtggttgttg taggtgggca gggcccaggt gcgggtgctg gtggtgatga     1560

ctctgtcgcc cagccatgtg gaatcgcaat gccaatttcc ggaggcatta cccactccgt     1620

cggcgccttc gttattgtct gccattggtg cgccaccgcc tgcagccatt gtaccagatc     1680

ccagacctga gggcgcggcg ggaggttctc cgagaggttg ggggtcgggc actgactctg     1740

agtcgccagt ctgcccaaag ttgagcttct ttttagcggg cggctggccg ttcttgccga     1800

tgcccgtgga ggagtcgggg gattctatgg gtctcttctt tccaggagcc gtcttagcgc     1860

cttcctcaac cagaccgaga ggttcgagaa cccgcttctt ggcctggaag actgctcgcc     1920

cgaggttgcc cccaaaagac gtatcttctt gaagacgctc ctgaaactcg gcgtcggcgt     1980

ggttgtactt gaggtacggg ttgtccccct gctcgagctg cttgtcgtag gccttgtcgt     2040

gctcgagggc cgcggcgtct gcctcgttga ccggctctcc cttgtcgagt ccgttgaagg     2100

gtccgaggta cctgtagcca ggaagcacca gaccccggcc gtcgtcctgc ttttgctggt     2160

tggctttggg tttcggggct ccaggtttca agtcccacca ctcgcgaatg ccctcagaga     2220

ggttgccctc gagccaatct ggaagataac catcggcagc catacctggt ttaagtcatt     2280

tattgctcag aaacacagtc atccaggtcc acgttggcca gatcgcaggc cgagcaagca     2340

atctcgggag cccgccccag cagatgatga atggcacaga gtttccgata cgtcctcttt     2400

ctgacgaccg gttgagattc tgacacgccg gggaaacatt ctgaacagtc tctggtcccg     2460

tgcgtgaagc aaatgttgaa attctgattc attctctcgc atgtcttgca ggggaacagc     2520

atctgaagca tgcccgcgtg acgagaacat ttgttttggt acctgtcggc aaagtccacc     2580

ggagctcctt ccgcgtctga cgtcgatgga tccgcgactg aggggcaggc ccgcttgggc     2640

tcgcttttat ccgcgtcatc gggggcgggt ctcttgttgg ctccaccctt tctgacgtag     2700

aactcatacg ccacctcggt cacgtgatcc tgcgcccagc ggaagaactc tttgacttcc     2760

tgctttgtca ccttgccaaa gtcatgctcc agacggcggg tgagttcaaa tttgaacatc     2820

cggtcttgta acggctgctg gtgctcgaag gtggtgctgt tcccgtcaat cacggcgcac     2880

atgttggtgt tggaagtgac gatcacgggg gtgggatcga tctgggcgga cgacttgcac     2940

ttttggtcca cgcgcacctt gctgccgccg agaatggcct tggcggactc cacgaccttg     3000

gccgtcatcc tgccctcctc ccaccagatc accatcttgt cgacgcaatc gttgaaggga     3060

aagttctcat tggtccagtt gacgcagccg tagaaagggc gaattc                    3106


<210> 4826
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4826
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Arg Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Asn Gly Gln 
145                 150                 155                 160 


Pro Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asp Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4827
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4827
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Arg Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Asn Gly Gln 
145                 150                 155                 160 


Pro Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4828
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4828
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Asn Gly Gln 
145                 150                 155                 160 


Pro Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4829
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4829
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4830
<211> 3098
<212> DNA
<213> Adeno-associated virus

<400> 4830
gaattcgccc ttcgcagaga ccaaagttca actgaaacga atcaaccggt ttattgatta       60

acaagtaatt acaggttacg ggtgaggtaa cgggtgccaa tggggcgagg ctcagtataa      120

accccttcgt tgttgacagc aaattccaca ttattagact tggcataatt tgaggtgtac      180

tgaatctctg gattccagcg tttgctgttt tctttctgca gttcccactc gatctccacg      240

ctgacctggc cggtgctgta ctgcgtgata aatgaggcaa actaggcagg agtaaacacc      300

cctggaggat tagcaggtac cggggtgttt ttgatgagaa tttgaggagg cgggtgtttg      360

agtccaaatc cgcccatcag gggagacggg tgaaagttgc cgtccgtgtg aggaattttg      420

gcccagatgg gaccctgcag gtacacgtcc cggttctgcc agaccatgcc gggcagagcc      480

ccctggctgt tgacagtctg tgtctggggt ccggccgtag acgattgcag gttgctggag      540

accacaccgt attcttctgt agccacggga ttggtggttt tgatctcctc ctcgctggtc      600

attagcacgt tttccagcgt tgtcttgttg gcagcccccg ttttgccaaa aaccagcact      660

ccgttgatgg gaaagaactg gccctcgtcg tccttgttgg tggccatggc tacgcccggg      720

ttggttaatg aatttctacc attcagatgg tatttagtgg ccccggtcca ggcaaagtta      780

ctgttgttgt tgctgtctat gttttttgac agtctctgct gccgataaca gggtccgggc      840

agccagttct ttgattgctc ggccatggtg ttgggcccag cctgatggaa ctgcagctcc      900

cttgtggacc ccgtagtgct ctgggtccgg gccaggtagt acaggtactg gtcgatgagg      960

ggattcatca gccggtccag gctctggctg tgcgcatagc tgctgtggaa aggcacttcc     1020

tcaaaggtgt agctgaattc aaagttattg cccgttctca gcatctgaga aggaaagtac     1080

tccaggcagt agaaggagga acgtcccata gactgactgc cgttgtttag agtcagatat     1140

ccgtactgag gaatcatgaa cacgtccgca gggaacggag ggaggcagcc ctggtgcgca     1200

gagccgagga cgtacggcag ttggtactcc gagtccgaga agacctgaat cgtgctggta     1260

aggttattag cgatggtcgt aacgccgtcg ttcgtcgtga cctccttgac ctggatgttg     1320

aacaacttga accgcagctt tctgggccgg aatccccagt tgttgttgat gagtcgctgc     1380

cagtcacgtg gtgagaagtg gcagtggaat ctgttgaagt caaaatagcc ccagggggtg     1440

ctgtagccga agaagtggtt gtcgttggta gccccgctct gacttgatat ctgcttgtag     1500

aggtggttgt tgtaggtggg cagggcccag gtgcgggtgc tggtggtgat gactctgtcg     1560

cccagccatg tggaatcgca atgccaattt ccggaggcat tacccactcc gtcggcgcct     1620

tcgttattgt ctgccattgg tgcgccaccg cctgcagcca ttgtaccaga tcccagacct     1680

gagggcgcgg cgggaggttc tccgagaggt tgggggtcgg gcactgactc tgagtcgcca     1740

gtctgcccaa agttgagctt ctttttagcg ggctgctggc ctttcttgcc gatgcccgtg     1800

gaggagtcgg gggattctat gggtctcttc tttccaggag ccgtcttagc gccttcctca     1860

accagaccga gaggttcgag aacccgcttc ttggcctgga agactgctcg cccgaggttg     1920

cccccaaaag acgtatcttc ttgaagacgc tcctgaaact cagcgtcggc gtggttgtac     1980

ttgaggtacg ggttgtcccc ctgctcgagc tgcttgtcgt aggccttgtc gtgctcgagg     2040

gccgcggcgt ctgcctcgtt gaccggctct cccttgtcga gtccgttgaa gggtccgagg     2100

tacttgtagc caggaagcac cagaccccgg ccgtcgtcct gcttttgctg gttggctttg     2160

ggtttcgggg ctccaggttt caagtcccac cactcgcgaa tgccctcaga gaggttgtcc     2220

tcgagccaat ctggaagata accatcggca gccatacctg gtttaagtca tttattgctc     2280

agaaacacag tcatccaggt ccacgttgac cagatcgcag gccgagcaag caatctcggg     2340

agcccgcccc agcagatgat gaatggcaca gagtttccga tacgtcctct ttctgacgac     2400

cggttgagat tctgacacgc cggggaaaca ttctgaacag tctctggtcc cgtgcgtgaa     2460

gcaaatgttg aaattctgat tcattctctc gcatgtcttg cagggaaaca gcatctgaag     2520

catgcccgcg tgacgagaac atttgttttg gtacctgtcg gcaaagtcca ccggagctcc     2580

ttccgcgtct gacgtcgatg gatccgcgac tgaggggcag gcccgcttgg gctcgctttt     2640

atccgcgtca tcgggggcgg gcctcttgtt ggctccaccc tttctgacgt agaactcatg     2700

cgccacctcg gtcacgtgat cctgcgccca gcggaagaac tctttgactt cctgctttgt     2760

caccttgcca aagtcctgct ccagacggcg ggtgagttca aatttgaaca tccggtcttg     2820

taacggctgc tggtgctcga aggtggtgct gttcccgtca atcacggcgc acatgttggt     2880

gttggaagtg acgatcacgg gggtgggatc gatctgggcg gacgacttgc acttttggtc     2940

cacgcgcacc ttgctgccgc cgagaatggc cttggcggac tccacgacct tggccgtcat     3000

cttgccctcc tcccaccaga tcaccatctt gtcgacgcaa tcgttgaagg gaaagttctc     3060

attggtccag ttgacgcagc cgtagaaagg gcgaattc                             3098


<210> 4831
<211> 729
<212> PRT
<213> Adeno-associated virus

<400> 4831
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Asp Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Ser Ser Ser Gly Ala Thr Asn Asp Asn His Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr 
        435                 440                 445             


Thr Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr 
    450                 455                 460                 


Met Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln 
465                 470                 475                 480 


Gln Gly Leu Ser Lys Asn Leu Asp Phe Asn Asn Asn Ser Asn Phe Ala 
                485                 490                 495     


Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr 
            500                 505                 510         


Asn Pro Gly Ile Pro Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe 
        515                 520                 525             


Phe Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn 
    530                 535                 540                 


Lys Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys 
545                 550                 555                 560 


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn 
                565                 570                 575     


Leu Gln Pro Ser Thr Ala Gly Pro Gln Ser Gln Thr Ile Asn Ser Gln 
            580                 585                 590         


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
        595                 600                 605             


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
    610                 615                 620                 


Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile 
625                 630                 635                 640 


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr 
                645                 650                 655     


Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
            660                 665                 670         


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
        675                 680                 685             


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val 
    690                 695                 700                 


Glu Phe Ala Val Asn Pro Asp Gly Val Tyr Thr Glu Pro Arg Pro Ile 
705                 710                 715                 720 


Gly Thr Arg Tyr Leu Pro Arg Asn Leu 
                725                 


<210> 4832
<211> 1458
<212> PRT
<213> Adeno-associated virus

<400> 4832
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Asp Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Thr Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Ser Ser Ser Gly Ala Thr Asn Asp Asn His Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr 
        435                 440                 445             


Thr Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr 
    450                 455                 460                 


Met Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln 
465                 470                 475                 480 


Gln Arg Leu Ser Lys Asn Leu Asp Phe Asn Asn Asn Ser Asn Phe Ala 
                485                 490                 495     


Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr 
            500                 505                 510         


Asn Pro Gly Ile Pro Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe 
        515                 520                 525             


Phe Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn 
    530                 535                 540                 


Lys Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys 
545                 550                 555                 560 


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn 
                565                 570                 575     


Leu Gln Ser Ser Thr Ala Gly Pro Gln Ser Gln Thr Ile Asn Ser Gln 
            580                 585                 590         


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
        595                 600                 605             


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
    610                 615                 620                 


Ser Pro Leu Met Gly Gly Phe Gly Leu Glu His Pro Pro Pro Gln Ile 
625                 630                 635                 640 


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr 
                645                 650                 655     


Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
            660                 665                 670         


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
        675                 680                 685             


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val 
    690                 695                 700                 


Glu Phe Ala Val Asn Pro Asp Gly Val Tyr Thr Glu Pro Arg Pro Ile 
705                 710                 715                 720 


Gly Thr Arg Tyr Leu Thr Arg Asn Leu Met Ala Ala Asp Gly Tyr Leu 
                725                 730                 735     


Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu Gly Ile Arg Glu Trp Trp 
            740                 745                 750         


Asp Leu Lys Pro Gly Ala Pro Lys Pro Lys Ala Asn Gln Gln Lys Gln 
        755                 760                 765             


Asp Asp Gly Arg Gly Leu Val Leu Pro Gly Tyr Lys Tyr Leu Gly Pro 
    770                 775                 780                 


Phe Asn Gly Leu Asp Lys Gly Glu Pro Val Asn Ala Ala Asp Ala Ala 
785                 790                 795                 800 


Ala Leu Glu His Asp Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp 
                805                 810                 815     


Asn Pro Tyr Leu Arg Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Arg 
            820                 825                 830         


Leu Gln Glu Asp Thr Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe 
        835                 840                 845             


Gln Ala Lys Lys Arg Val Leu Glu Pro Leu Gly Leu Val Glu Glu Gly 
    850                 855                 860                 


Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro Ile Gly Ser Pro Asp Ser 
865                 870                 875                 880 


Ser Thr Gly Ile Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Lys Leu 
                885                 890                 895     


Asn Phe Gly Gln Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro 
            900                 905                 910         


Leu Gly Glu Pro Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met 
        915                 920                 925             


Ala Ala Gly Gly Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp 
    930                 935                 940                 


Gly Val Gly Asn Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu 
945                 950                 955                 960 


Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr 
                965                 970                 975     


Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Ser Ser Ser Ser Gly Ala 
            980                 985                 990         


Thr Asn Asp Asn His Tyr Phe Gly  Tyr Ser Thr Pro Trp  Gly Tyr Phe 
        995                 1000                 1005             


Asp Phe  Asn Arg Phe His Cys  His Phe Ser Pro Arg  Asp Trp Gln 
    1010                 1015                 1020             


Arg Leu  Ile Asn Asn Asn Trp  Gly Phe Arg Pro Lys  Lys Leu Arg 
    1025                 1030                 1035             


Phe Lys  Leu Leu Asn Ile Gln  Val Lys Glu Val Thr  Thr Asn Asp 
    1040                 1045                 1050             


Gly Val  Thr Thr Ile Ala Asn  Asn Leu Thr Ser Thr  Val Gln Val 
    1055                 1060                 1065             


Phe Ser  Asp Ser Glu Tyr Gln  Leu Pro Tyr Val Leu  Gly Ser Ala 
    1070                 1075                 1080             


His Gln  Gly Cys Leu Pro Pro  Phe Pro Ala Asp Val  Phe Met Ile 
    1085                 1090                 1095             


Pro Gln  Tyr Gly Tyr Leu Thr  Leu Asp Asn Gly Ser  Gln Ser Val 
    1100                 1105                 1110             


Gly Arg  Ser Ser Phe Tyr Cys  Leu Glu Tyr Phe Pro  Ser Gln Met 
    1115                 1120                 1125             


Leu Arg  Thr Gly Asn Asn Phe  Glu Phe Ser Tyr Ser  Phe Glu Asp 
    1130                 1135                 1140             


Val Pro  Phe His Ser Ser Tyr  Ala His Ser Gln Ser  Leu Asp Arg 
    1145                 1150                 1155             


Leu Met  Asn Pro Leu Ile Asp  Gln Tyr Leu Tyr Tyr  Leu Ala Arg 
    1160                 1165                 1170             


Thr Gln  Ser Thr Thr Gly Ser  Thr Arg Glu Leu Gln  Phe His Gln 
    1175                 1180                 1185             


Ala Gly  Pro Asn Thr Met Ala  Glu Gln Ser Lys Asn  Trp Leu Pro 
    1190                 1195                 1200             


Gly Pro  Cys Tyr Arg Gln Gln  Arg Leu Ser Lys Asn  Leu Asp Phe 
    1205                 1210                 1215             


Asn Asn  Asn Ser Asn Phe Ala  Trp Thr Ala Ala Thr  Lys Tyr His 
    1220                 1225                 1230             


Leu Asn  Gly Arg Asn Ser Leu  Thr Asn Pro Gly Ile  Pro Met Ala 
    1235                 1240                 1245             


Thr Asn  Lys Asp Asp Glu Asp  Gln Phe Phe Pro Ile  Asn Gly Val 
    1250                 1255                 1260             


Leu Val  Phe Gly Lys Thr Gly  Ala Ala Asn Lys Thr  Thr Leu Glu 
    1265                 1270                 1275             


Asn Val  Leu Met Thr Ser Glu  Glu Glu Ile Lys Thr  Thr Asn Pro 
    1280                 1285                 1290             


Val Ala  Thr Glu Glu Tyr Gly  Val Val Ser Ser Asn  Leu Gln Ser 
    1295                 1300                 1305             


Ser Thr  Ala Gly Pro Gln Ser  Gln Thr Ile Asn Ser  Gln Gly Ala 
    1310                 1315                 1320             


Leu Pro  Gly Met Val Trp Gln  Asn Arg Asp Val Tyr  Leu Gln Gly 
    1325                 1330                 1335             


Pro Ile  Trp Ala Lys Ile Pro  His Thr Asp Gly Asn  Phe His Pro 
    1340                 1345                 1350             


Ser Pro  Leu Met Gly Gly Phe  Gly Leu Lys His Pro  Pro Pro Gln 
    1355                 1360                 1365             


Ile Leu  Ile Lys Asn Thr Pro  Val Pro Ala Asn Pro  Pro Glu Val 
    1370                 1375                 1380             


Phe Thr  Pro Ala Lys Phe Ala  Ser Phe Ile Thr Gln  Tyr Ser Thr 
    1385                 1390                 1395             


Gly Gln  Val Ser Val Glu Ile  Glu Trp Glu Leu Gln  Lys Glu Asn 
    1400                 1405                 1410             


Ser Lys  Arg Trp Asn Pro Glu  Ile Gln Tyr Thr Ser  Asn Tyr Ala 
    1415                 1420                 1425             


Lys Ser  Asn Asn Val Glu Phe  Ala Val Asn Pro Asp  Gly Val Tyr 
    1430                 1435                 1440             


Thr Glu  Pro Arg Pro Ile Gly  Thr Arg Tyr Leu Thr  Arg Asn Leu 
    1445                 1450                 1455             


<210> 4833
<211> 729
<212> PRT
<213> Adeno-associated virus

<400> 4833
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Asp Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Thr Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Ser Ser Ser Gly Ala Thr Asn Asp Asn His Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr 
        435                 440                 445             


Thr Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr 
    450                 455                 460                 


Met Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln 
465                 470                 475                 480 


Gln Arg Leu Ser Lys Asn Leu Asp Phe Asn Asn Asn Ser Asn Phe Ala 
                485                 490                 495     


Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr 
            500                 505                 510         


Asn Pro Gly Ile Pro Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe 
        515                 520                 525             


Phe Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn 
    530                 535                 540                 


Lys Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys 
545                 550                 555                 560 


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn 
                565                 570                 575     


Leu Gln Ser Ser Thr Ala Gly Pro Gln Ser Gln Thr Ile Asn Ser Gln 
            580                 585                 590         


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
        595                 600                 605             


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
    610                 615                 620                 


Ser Pro Leu Met Gly Gly Phe Gly Leu Glu His Pro Pro Pro Gln Ile 
625                 630                 635                 640 


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr 
                645                 650                 655     


Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
            660                 665                 670         


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
        675                 680                 685             


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val 
    690                 695                 700                 


Glu Phe Ala Val Asn Pro Asp Gly Val Tyr Thr Glu Pro Arg Pro Ile 
705                 710                 715                 720 


Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 


<210> 4834
<211> 3075
<212> DNA
<213> Adeno-associated virus

<400> 4834
tgagaacttt cctttcaacg attgcgtcgg acaagatggt gatctggtgg gaggagggga       60

agatgaccgc caaggtcgtg gagtcggcca aagccattct tggaggaagc aaggtgcgtg      120

tggaccagaa atgcaagtcc tcggcccaga tagacccgac tcccgtgatc gtcacctcca      180

acaccaacat gtgcgccgtg attgacggga actcaacgac cttcgagcac cagcagccgt      240

tgcaagaccg gatgttcaaa tttgaactta cccgccgtct ggatcatgac tttggaaagg      300

tcaccaagca ggaagtgaaa gactttttcc ggtgggcaaa ggatcacgtg gttgaggtgg      360

agcatgaatt ctacgtcaaa aagggtggag ctaagaaaag acccgccccc agtgacgcag      420

atataagtga gcccaaacgg gcgcgcgagt cagttgcgca gccatcaacg tcagacgcgg      480

aagcttcgat caactacgcg gacaggtacc aaaaacaaat gttctcgtca cgtgggcatg      540

aatctgatgc tgtttccctg cagacaatgc gagagaatga atcagaattc aaatatctgc      600

ttcactcacg gacagaaaga ctgtttagag tgctttcccg tgtcagaatc tcaacccgtt      660

tctgtcgtca aaaaggcgta tcagaaactg tgctacattc atcatatcat gggaaaggtg      720

ccagacgctt gcactgcctg cgatctggtc aatgtggatt tggatgactg catctctgaa      780

caataaatga tttaaatcag gtatggctgc cgatggttat cctccagatt ggctcgagga      840

cactctctct gaagggataa gacagtggtg gaagctcaaa cctggcccac caccaccaaa      900

gcccgcagag cggcataagg acgacagcag gggtcttgtg cttcctgggt acaagtacct      960

cggacccttc aacggactcg acaaggggga gccggtcaac gaggcagacg ccgcggccct     1020

cgagcacgac aaggcctacg accggcagct cgacagcgga gacaacccgt acctcaagta     1080

caaccacgcc gacgcagagt ttcaggagcg ccttaaagaa gatacgtctt ttgggggcaa     1140

cctcggacga gcagtcttcc aggcgaaaaa gagggttctt gaacctctgg gcctggttga     1200

ggaacctgtt aagacggctc cgggaaaaaa gaggccggta gagcactctc ctgtggagcc     1260

agactcctcc tcgggaaccg gaaaagcggg ccagcggcct gcaagaaaaa gattaaattt     1320

tggtcagact ggagacgcag actccgtacc tgacccccag cctctcggac agccaccagc     1380

agccccctct ggtctgggat ctactacaat ggctacaggc agtggcgcac caatggcaga     1440

caataacgag ggtgccgatg gagtgggtaa ttcctcagga aattggcatt gcgattccca     1500

atggctgggc gacagagtca tcaccaccag cacccgaacc tgggccctgc ccacatacaa     1560

caaccacctc tacaagcaaa tctccagcca atcaggagcc agcaacgaca accactactt     1620

tggctacagc accccctggg ggtattttga cttcaacaga ttccactgcc acttttcacc     1680

acgtgactgg caaagactca tcaacaacaa ctggggattc cggcccaaaa gactcaactt     1740

caagctcttt aatattcaag tcaaagaggt cacgcagaat gacggtacga cgacgattgc     1800

caataacctt accagcacgg ttcaggtgtt tactgactcg gagtaccagc tcccgtacgt     1860

cctgggctcg gcgcatcaag gatgcctccc gccgtttcca gcggacgtct tcatggtccc     1920

acagtatgga tacctcaccc tgaacaacgg gagtcaggcg gtaggacgct cttcctttta     1980

ctgcctggag tactttcctt ctcagatgct gcgtactgga aacaactttc agttcagcta     2040

cacttttgaa gacgtgcctt tccacagcag ctacgctcac agccagagtc tggatcggct     2100

gatgaatcct ctgatcgacc agtacctgta ttatctgaac aagacacaaa caaatagtgg     2160

aactcttcag cagtctcggc tactgtttag ccaagctgga ccaaccaaca tgtctcttca     2220

agctaaaaac tggctgcctg gaccttgcta cagacagcag cgtctgtcaa aacaggcaaa     2280

cgacaacaac aacagcaact ttccctggac tgcagctaca aagtatcatc taaatggccg     2340

ggactcgttg gttaatccag gaccagctat ggccagtcac aaggatgacg aagaaaagtt     2400

tttccccatg catggaaccc tgatatttgg taaacaagga acaaatgcca acgacgcgga     2460

tttggaaaat gtcatgatta cagatgaaga agaaatcagg gccaccaatc ccgtggctac     2520

ggagcagtac gggactgtgt caaataattt gcaaaactca aacactggtc caactactgg     2580

aactgtcaat cgccaaggag cgttacctgg tatggtgtgg caggatcgag acgtgtacct     2640

gcagggaccc atttgggcca agattcctca caccgatgga cactttcatc cttctccact     2700

gatgggaggt tttggactca aacacccgcc tcctcagatc atgatcaaaa acactcccgt     2760

tccagccaat cctcccacaa acttcagttc tgccaagttt gcttctttca tcacacagta     2820

ttccacggga caggtcagcg tggagatcga gtgggagctg cagaaggaga acagcaaacg     2880

ctggaatccc gaaattcagt acacttccaa ctacaacaag tctgttaatg tggactttac     2940

tgtggacact aatggtgtgt attcagagcc tcgccccatt ggcaccagat acctgactcg     3000

taatctgtaa ttgcttgtta atcaataaac cgtttaattc gtttcagttg aactttggtc     3060

tctgcgaagg gcgaa                                                      3075


<210> 4835
<211> 3142
<212> DNA
<213> Adeno-associated virus

<400> 4835
aaaacgacgg gccagtgatt gtaatacgac tcactatagg gcgaaattga aattagcggc       60

cgcgaattcg cctttcgcag agaccaaagt tcaactgaaa cgaattaaac ggtttattga      120

ttaacaagca attacagatt acgagtcagg tatctggtgc caatggggcg aggctctgaa      180

tacacaccat tagtgtccac agtaaagtcc acattaacag acttgttgta gttggaagtg      240

tactgaattt cgggattcca gcgtttgctg ttctccttct gcagctccca ctcgatctcc      300

acgctgacct gtcccgtgga atactgtgtg atgaaagaag caaacttggc agaactgaag      360

tttgtgggag gattggctgg aacgggagtg tttttgatca tgatctgagg aggcgggtgt      420

ttgagtccaa aacctcccat cagtggagaa ggatgaaagt gtccatcggt gtgaggaatc      480

ttggcccaaa tgggtccctg caggtacacg tctcgatcct gccacaccat accaggtaac      540

gctccttggt gattgacagt tccagtagtt ggaccagtgt ttgagttttg caaattattt      600

gacacagtcc cgtactgctc cgtagccacg ggattggtgg ccctgatttc ttcttcatct      660

gtaatcatga cattttccaa atccgcgtcg ttggcatttg ttccttgttt accaaatatc      720

agggttccat gcatggggaa aaacttttct tcgtcatcct tgtgactggc catagctggt      780

cctggattaa ccaacgagtc ccggccattt agatgatact ttgtagctgc agtccaggga      840

aagttgctgt tgttgttgtc gtttgcctgt tttgacagac gctgctgtct gtagcaaggt      900

ccaggcagcc agtttttagc ttgaagagac atgttggttg gtccagcttg gctaaacagt      960

agccgagact gctgaagagt tccactattt gtttgtgtct tgttcagata atacaggtac     1020

tggtcgatca gaggattcat cagccgatcc agactctggc tgtgagcgta gctgctgtgg     1080

aaaggcacgt cttcaaaagt gtagctgaac tgaaagttgt ttccagtacg cagcatctga     1140

gaaggaaagt actccaggca gtaaaaggaa gagcgtccta ccgcctgact cccgttgttc     1200

agggtgaggt atccatactg tgggaccatg aagacgtccg ctggaaacgg cgggaggcat     1260

ccttgatgcg ccgagcccag gacgtacggg agctggtact ccgagtcagt aaacacctga     1320

accgtgctgg taaggttatt ggcaatcgtc gtcgtaccgt cattctgcgt gacctctttg     1380

acttgaatat taaagagctt gaagttgagt cttttgggcc ggaatccccg gttgttgttg     1440

acgagtcttt gccagtcacg tggtgaaaag tggcagtgga atctgttgaa gtcaaaatac     1500

ccccaggggg tgctgtagcc aaagtagtgg ttgtcgttgc tggctcctga ttggctggag     1560

atttgcttgt agaggtggtt gttgtatgtg ggcagggccc aggttcgggt gctggtggtg     1620

atgactctgt cgcccagcca ttgggaatcg caatgccaat ttcctgagga attacccact     1680

ccatcggcac cctcgttatt gtctgccatt ggtgcgccac tgcctgtagc cattgtagta     1740

gatcccagac cagagggggc tgctggtggc tgtccgagag gctgggggtc aggtacggag     1800

tctgcgtctc cagtctgacc aaaatttaat ctttttcttg caggctgctg gcccgctttt     1860

ccggttcccg aggaggagtc tggctccaca ggagagtgct ctaccggcct cttttttccc     1920

ggagccgtct taacaggctc ctcaaccagg cccagaggtt caagaaccct ctttttcgcc     1980

tggaagactg ctcgtccgag gttgccccca aaagacgtat cttctttaag gcgctcctga     2040

aactctgcgt cggcgtggtt gtacttgagg tacgggttgt ctccgctgtc gagctgccgg     2100

tcgtaggcct tgtcgtgctc gagggccgcg gcgtctgcct cgttgaccgg ctcccccttg     2160

tcgagtccgt tgaagggtcc gaggtacttg tacccaggaa gcacaagacc cctgctgtcg     2220

tccttatgcc gctctgcggg ctttggtggt ggtgggccag gtttgagctt ccaccactgt     2280

cttattcctt cagagagagt gtcctcgagc caatctggaa gataaccatc ggcagccata     2340

cctgatttaa atcatttatt gttcagagat gcagtcatcc aaatccacat tgaccagatc     2400

gcaggcagtg caagcgtctg gcacctttcc catgatatga tgaatgtagc acagtttctg     2460

atacgccttt ttgacgacag aaacgggttg agattctgac acgggaaagc actctaaaca     2520

gtctttctgt ccgtgagtga agcagatatt tgaattctga ttcattctct cgcattgtct     2580

gcagggaaac agcatcagat tcatgcccac gtgacgagaa catttgtttt ggtacctgtc     2640

cgcgtagttg atcgaagctt ccgcgtctga cgtcgatggc tgcgcaactg actcgcgcgc     2700

ccgtttgggc tcacttatat ctgcgtcact gggggcgggt cttttcttag ctccaccctt     2760

tttgacgtag aattcatgct ccacctcaac cacgtgatcc tttgcccacc ggaaaaagtc     2820

tttcacttcc tgcttggtga cctttccaaa gtcatgatcc agacggcggg taagttcaaa     2880

tttgaacatc cggtcttgca acggctgctg gtgctcgaag gtcgttgagt tcccgtcaat     2940

cacggcgcac atgttggtgt tggaggtgac gatcacggga gtcgggtcta tctgggccga     3000

ggacttgcat ttctggtcca cacgcacctt gcttcctcca agaatggctt tggccgactc     3060

cacgaccttg gcggtcatct tcccctcctc ccaccagatc accatcttgt cgacgcaatg     3120

gtaaaaggaa agttctcatt gg                                              3142


<210> 4836
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4836
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcagagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttaaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acatacaaca accacctcta caagcaaatc      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaaaaga ctcaacttca agctctttaa tattcaagtc      960

aaagaggtca cgcagaatgg cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tgggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cttttgaaga cgtgcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc aaccaacatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaaa caggcaaacg gcaacaacaa cagcaacttt     1500

ccctggactg cagctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa ggatgacgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt catgattaca     1680

gatgaagaag aaatcagggc caccaatccc gtggctacgg agcagtacgg gactgtgtca     1740

aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga cgggaggttt tggactcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4837
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4837
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Gly Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Gly Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Ala Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Thr Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4838
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4838
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc tcgcagagcg gcatcaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aaaggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc atcagcctgc gagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag cccccacaag tctgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc gaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgtcac ttctccccac gtgattggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc acggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caaccttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccggctga tgaatcctct gatcgaccag     1320

tatctatatt atctgaacag gacacaatca aatagtggaa ctcttcagca gtctaggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctttcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggagcatgt tatgattaca     1680

gatgaagaag aaatcaggac caccaatcct gtggctacag agcagtacgg aaacgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actacagaaa atgtcaatca ccagggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgacggaca ctttcaccct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcaaatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

tacagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggcca ggtcagcgtg     2040

gagattgagt gggagctgcg gaaggagaac agcaaacgct ggaaccccga gatccagtat     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4839
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4839
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Leu Ala Glu Arg His Gln Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Thr Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Leu Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu His Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Asn Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Glu Asn Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Tyr Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Arg Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4840
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4840
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcatcaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aaaggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc atcagcctgc gagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag cccccacaag tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc gaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgtcac ttctccccac gtgattggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaggaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccggctga tgaatcctct gatcgaccag     1320

tatctatatt atctgaacag gacacaatca aatagtggaa ctcttcagca gtctaggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctttcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcgtcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggagcatgt tatgattaca     1680

gatgaagaag aaatcaggac caccaatcct gtggctacag agcagtacgg aaacgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actacagaaa atgtcaatca ccagggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgacggaca ctttcaccct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcaaatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggcca ggtcagcgtg     2040

gagattgagt gggagctgca gaaggagaac agcaaacgct ggaaccccga gatccagtat     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4841
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4841
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Gln Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr Arg Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu His Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Asn Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Glu Asn Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4842
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4842
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcatcaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aaaggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc atcagcctgc gagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag cccccacaag tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc gaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgtcac ttctccccac gtgattggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgccct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccggctga tgaatcctct gatcgaccag     1320

tatctatatt atctgaacag gacacaatca aatagtggaa ctcttcagca gtctaggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctttcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tgggaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggagcatgt tatgattaca     1680

gatgaagaag aaatcaggac caccaatcct gtggctacag agcagtacgg aaacgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actacagaaa atgtcaatca ccagggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgacggaca ctttcaccct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcaaatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggcca ggtcagcgtg     2040

gagattgagt gggagctgca gaaggagaac agcaaacgct ggaaccccga gatccagtat     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4843
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4843
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Gln Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Pro Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu His Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Asn Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Glu Asn Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4844
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4844
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcaaaaaaga gggttcttga acctctgggc ctggttgagg agcctgttaa aacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttgaatttcg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacttg ggccctgccc acctacaaca accatctcta caagcaaatc      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctgc agggcggcaa cacacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttctttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga gatccagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg ttgacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4845
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4845
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Gly Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4846
<211> 3161
<212> DNA
<213> Adeno-associated virus

<400> 4846
gattgaattt agcggccgcg aattcgccct tgctgcgtca actggaccaa tgagaacttt       60

ccattcaatg attgcgtcga caagatggtg atctggtggg aggagggaaa gatgaccgcc      120

aaggtcatgg agtcggccaa agccattctc ggaggaagca aggtgcgcgt ggaccagaaa      180

tgtaagtcct cggcccagat agacccgact cccgtgattg tcacctccaa caccaacatg      240

tgcgccgtga ttgacgggaa ctcaacgacc ttcgagcacc agcagccgtt gcaagaccgg      300

atgttcaaat ttgaactcac ccgccgtctg gatcatgact ttgggaaggt caccaagcag      360

gaagtcaaag actttttccg gtgggcaaag gatcacgtgg ttgaggtgga gcatgaattc      420

tacgtcaaaa agggtggagc caagaaaaga cccgccccca gtgacgcaga tataagtgag      480

cccaaacggg cgcgcgggtc agttgcgcag ccatcgacgt cagacgcgga agcttcgatc      540

aactacgcgg acaggtacca aaacaaatgt tctcgtcacg tgggcatgaa tctgatgctg      600

tttccctgca gacaatgcga gagaatgaat caaaattcaa atatctgctt cactcacgga      660

cagaaggact gtttagagtg ctttcccgtg tcagaatctc aacccgtttc tgtcgtcaaa      720

aaggcgtatc agaaactttg ctacattcat catatcatgg gaaaggtgcc agacgcttgc      780

actgcctgcg atctggtcaa tgtggatttg gatgactgca tctctgaaca ataaatgatt      840

taaatcaggt atggctgccg atggttatct tccagattgg ctcaaggaca ctctctctga      900

aggaataaga cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg      960

gcataaggac gacagcgggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa     1020

cggactcgac aagggagagc cggtcaacga ggcagacgcc gcggccctcg agtacgacaa     1080

ggcctacgac cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga     1140

cgcggagttt caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc     1200

agtcttccag gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa     1260

gacggctccg ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc     1320

gggaacagga aaagcgggcc agcagcctgc gagaaagaga ttgaattttg gtcagactgg     1380

agacgcagac tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg     1440

tctgggaact aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg     1500

cgccgacgga gtgggtaatt cctcgggaag ttggcattgc gattccacat ggatgggcga     1560

cagagtcatc accaccagca cccgaacctg ggctctgccc acctacaaca accatctgta     1620

caagcagatc tccagccaat caggagccag caacgacaac cactactttg gctacagcac     1680

cccttggggg tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca     1740

aagactcatc aacaacaact ggggattccg gcccaagaga ctcaacttca agctctttaa     1800

cattcaagtc aaggaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac     1860

cagcacggtt caggtgttta ctgactcgga gtaccagctc ccgtacgtcc ccggctcggc     1920

gcatcaagga tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata     1980

cctcaccctg aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta     2040

ctttccttct cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgagga     2100

tgttcctttc cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct     2160

catcgaccag tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca     2220

gtccaggctt cagttttctc aggccggagc aagtgacatt cgggaccagt ctaggaactg     2280

gcttcctgga ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa     2340

cagtgaatac tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt     2400

gaatccgggc ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcaaag     2460

cggggttctc atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt     2520

catgattaca gacgaagagg aaatcagaac caccaatccc gtggccacgg agcagtatgg     2580

ttctgtatct accaacctcc agagcggcaa cacacaagca gctactgcag atgtcaacac     2640

acaaggcgtt cttccaggca tggtctggca ggacagagac gtgcacctgc aggggcctat     2700

ctgggcaaag attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt     2760

tggacttaaa caccctcctc cacagattct catcaagaac accccggtac ctgcaaatcc     2820

ttcgaccacc ttcagtgcgg caaagtttgc ttccttcatc acacagtatt ccacagggca     2880

ggtcagcgtg gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaaccccga     2940

gatccagtac acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa     3000

tggtgtgtat tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaatt     3060

gcttgttaat caataaaccg tttaattcgt ttcagttgaa ctttggtctc tgcgaagggc     3120

gaattcgttt aaaccctgca ggactagtcc ctttagtgag g                         3161


<210> 4847
<211> 3162
<212> DNA
<213> Adeno-associated virus

<400> 4847
gaattgaatt tagcggccgc gaattcgccc ttcgcagaga ccaaagttca actgaaacga       60

attaaacggt ttattgatta acaagcaatt acagattacg agtcaggtat ctggtgccaa      120

tggggcgagg ctctgaatac acgccattag tgtccacagt aaagtccaca ttaacagact      180

tgttgtagtt ggaagtgtac tgaatttcgg gattccagcg tttgctgttt tccttctgca      240

gctcccactc gatctccacg ctgacctgtc ccgtggagta ctgtgtgatg aaggaagcaa      300

actttgccgc actgaaggtg gtcgaaggat tcgcaggtac cggggtgttc ttgatgagaa      360

tctgtggagg agggtgttta agtccgaatc cacccatgag gggagagggg tgaaaatgtc      420

cgtccgtgtg tggaatcttt gcccagatgg gcccctgaag gtacacatct ctgtcctgcc      480

agaccatgcc tggaagaacg ccttgtgtgt tgacatctgc ggtagctgct tgtctgttgc      540

ctctctggag gttggtagat acagaaccgt actgctccgt agccacggga ttggttgtcc      600

tgatttcctc ttcgtctgta atcatgacct tttcaatgtc cacatttgtt ttctctgagc      660

cttgcttccc aaagatgaga accccgctct gaggaaaaaa cttttcttca ttgtccttgt      720

ggcttgccat ggccgggccc ggattcacca gagagtctct gccattgagg tggtacttgg      780

tagctccagt ccacgagtat tcactgttgt tgttatccgc agatgtcttt gatactcgct      840

gctggcggta acagggtcca ggaagccagt tcctagactg gtcccgaatg tcactcgctc      900

cggcctgaga aaactgaagc cttgactgcg tggtggttcc acttggagtg tttgttgtgc      960

tcaagtaata caggtactgg tcgatgagag gattcatgag acggtccaga ctctggctgt     1020

gagcgtagcc gctgtggaaa ggaacgtcct caaaagtgta gctgaaggta aagttgtttc     1080

cggtacgcag catctgagaa ggaaagtact ccaggcagta aaatgaagag cgtcctactg     1140

cctgactccc gttgttcagg gtgaggtatc catactgtgg caccatgaag acgtctgctg     1200

ggaacggcgg gaggcatcct tgatgcgccg agccgaggac gtacgggagc tggtactccg     1260

agtcagtaaa cacctgaacc gtgctggtaa ggttattggc aatcgtcgtc gtaccgtcat     1320

tctgcgtgac ctctttgact tgaatgttaa agagcttgaa gttgagtctc ttgggtcgga     1380

atccccagtt gttgttgatg agtctttgcc agtcacgtgg tgaaaagtgg cagtggaatc     1440

tgttgaagtc aaaatacccc caaggggtgc tgtagccaaa gtagtgattg tcgttcgagg     1500

ctcctgattg gctggaaatt tgtttgtaga ggtggttgtt gtaggtgggc agggcccagg     1560

ttcgggtgct ggtggtgatg actctgtcgc ccatccatgt ggaatcgcaa tgccaatttc     1620

ccgaggaatt acccactccg tcggcgccct cgttattgtc tgccattggt gcgccactgc     1680

ctgtagccat cgtattagtt cccagaccag agggggctgc tggtggctgt ccgagaggct     1740

gggggtcagg tactgagtct gcgtctccag tctgaccaaa attcaatctt tttcttgcag     1800

gctgctggcc cgcctttccg gttcccgagg aggagtctgg ctccacagga gagtgctcta     1860

ccggcctctt ttttcctgga gccgtcttga caggttcccc aaccaggccc agaggttcaa     1920

gaaccctctt tttcgcctgg aagactgctc gtccgaggtt gcccccaaaa gacgtatctt     1980

ctttaaggcg ctcctgaaac tccgcgtcgg cgtggttgta cttgaggtac gggttgtctc     2040

cgctgtcgag ctgccggtcg taggctttgt cgtgctcgag ggccgcggcg tctgcctcgt     2100

tgaccggctc tcccttgtcg agtccgttga agggtccgag gtacttgtac ccaggaagca     2160

caagacccct gctgtcgtcc ttatgccgct ctgcgggctt tggtggtggt gggccaggtt     2220

tgagcttcca ccactgtctt attccttcag agagagtgtc ctcgagccaa tctggaagat     2280

aaccatcggc agccatacct gatttaaatc atttattgtt caaagatgca gtcatccaaa     2340

tccacattga ccagatcgca ggcagtgcaa gcgtctggca cctttcccat gatatgatga     2400

atgtagcaca gtttctgata cgcctttttg acgacagaaa cgggttgaga ttctgacacg     2460

ggaaagcact ctaaacagtc tttctgtccg tgagtgaagc agatatttga attctgattc     2520

attctctcgc attgtctgca gggaaacagc atcagattca tgcccacgtg acgagaacat     2580

ttgttttggt acctgtctgc gtagttgatc gaagcttccg cgtctgacgt cgatggctgc     2640

gcaactgact cgcgcacccg tttgggctca cttatatctg cgtcactggg ggcgggtctt     2700

ttcttggctc cacccttttt gacgtagaat tcatgctcca cctcaaccac gtgatccttt     2760

gcccaccgga aaaagtcttt gacttcctgc ttggtgacct tcccaaagtc atgatccaga     2820

cggcgggtga gttcaaattt gaacatccgg tcttgcaacg gctgctggtg ttcgaaggtc     2880

gttgagttcc cgtcaatcac ggcgcacatg ttggtgttgg aggtgacgat cacgggagtc     2940

gggtctatct gggccgagga cttgcatttc tggtccacgc gcaccttgct tcctccgaga     3000

atggctttgg ccgactccac gaccttggcg gtcatcttcc cctcctccca ccagatcacc     3060

atcttgtcga cacagtcgtt gaagggaaag ttctcattgg tccagttgac gcagcaaggg     3120

cgaattcgtt taaacctgca ggactagtcc ctttagtgag gg                        3162


<210> 4848
<211> 3164
<212> DNA
<213> Adeno-associated virus

<400> 4848
gcgaattgaa tttagcggcc gcgaattcgc ccttcgcaga gaccaaagtt caactgaaac       60

gaattaaacg gtttattgat taacaagcaa ttacaaatta cgagtcaggt atctggtgcc      120

aatggggcga ggctctgaat acacgccatt agtgtccaca gtaaagtcca cattaacaga      180

cttgttgtag ttggaagtgt actgaatttc gggattccag cgtttgctgt tttccttctg      240

cagctcccac tcgatctcca cgctgacctg tcccgtggag tactgtgtga tgaaggaagc      300

aaactttgcc gcactgaagg tggtcgaagg attcgcaggt accggggtgt tcttgatgag      360

aatctgtgga ggagggtgtt taggtccgaa tccacccatg aggggagagg ggtgaaaatg      420

tccgtccgtg tgtggaatct ttgcccagat gggcccctga aggtacacat ctctgtcctg      480

ccagaccatg cctggaagaa cgccttgtgt gttgacatct gcggtagctg cttgtctgtt      540

gcctctctgg aggttggtag atacagaacc atactgctcc gtagccacgg gattggttgt      600

cctgatttcc tcttcgtctg taatcatgac cttttcaatg tccacatttg ttttctctga      660

gccttgcttc ccaaagatga gaaccccgct ctgaggaaaa aacttttctt cattgtcctt      720

gtggcttgcc atggccgggc ccggattcac cagagagtct ctgccattga ggtggtactt      780

ggtagctcca gtccacgagt attcactgtt gttgttatcc gcagatgtct ttgatactcg      840

ctgctggcgg taacagggtc caggaagcca gttcctagac tggtcccgaa tgtcactcgc      900

tccggcctga gaaaactgaa gccttgactg cgtggtggtt ccacttggag tgtttgttgt      960

gctcaagtaa tacaggtact ggtcgatgag aggattcatg agacggtcca gactctggct     1020

gtgagcgtag ctgctgtgga aaggaacgtc ctcaaaagtg tagctgaagg taaagttgtt     1080

tccggtacgc agcatctgag aaggaaagta ctccgggcag taaaatgaag agcgtcctac     1140

tgcctgactc ccgttgctca gggtgaggta tccatactgt ggcaccatga agacgtctgc     1200

tgggaacggc gggaggcatc cttgatgcgc cgagccgagg acgtacggga gctggtactc     1260

cgagtcagta aacacctgaa ccgtgctggt aaggttattg gcaatcgtcg tcgtaccgtc     1320

attctgcgtg acctctttga cttgaatgtt aaagagcttg aagttgagtc tcttgggtcg     1380

gaatccccag ttgttgttga tgagtctttg ccagtcacgt ggtgaaaagt ggcagtggaa     1440

tctgttgaag tcaaaatacc cccaaggggt gctgtagcca aagtagtgat tgtcgttcga     1500

ggctcctgat tggctggaaa tttgtctgta gaggtggttg ttgtaggtgg gcagggccca     1560

ggttcgggtg ctggtggtga tgactctgtc gcccatccat gtggaatcgc aatgccgatt     1620

tcccgaggaa ttacccactc cgtcggcgcc ctcgttattg tctgccattg gtgcgccact     1680

gcctgtagcc atcgtattag ttcccagacc agagggggct gctggtggct gtccgagagg     1740

ctgggggtca ggtactgagt ctgcgtctcc agtctgacca aaattcaatc tttttcttgc     1800

aggctgctgg cccgcctttc cggttcccga ggaggagtct ggctccacag gagagtgctc     1860

taccggcctc ttttttcccg gagccgtctt aacaggttcc ccaaccaggc ccagaggttc     1920

aagaaccctc tttttcgcct ggaagactgc tcgtccgagg ttgcccccaa aagacgtatc     1980

ttctttaagg cgctcctgaa actccgcgtc ggcgtggttg tacttgaggt acgggttgtc     2040

tccgctgtcg agctgccggt cgtaggcttt gtcgtgctcg agggccgcgg cgtctgcctc     2100

gttgaccggc tctcccttgt cgagtccgtt gaagggtccg aggtacttgt acccaggaag     2160

cacaagaccc ctgctgtcgt ccttatgccg ctctgcgggc tttggtggtg gtgggccagg     2220

tttgagcttc caccactgtc ttattccttc agagagagtg tcctcgagcc aatctggaag     2280

ataaccatcg gcagccatac ctgatttaaa tcatttattg ttcaaagatg cagtcatcca     2340

aatccacatt gaccagatcg caggcagtgc aagcgtctgg cacctttccc atgatatgat     2400

gaatgtagca cagtttctga tacgcctttt tgacgacaga aacgggttga gattctgaca     2460

cgggaaagca ctctaaacag tctttctgtc cgtgagtgaa gcagatattt gaattctgat     2520

tcattctctc gcattgtctg cagggaaaca gcatcagatt catgcccacg tgacgagaac     2580

atttgttttg gtacctgtct gcgtagttga tcgaagcttc cgcgtctgac gtcgatggct     2640

gcgcaactga ctcgcgcacc cgtttgggcc cacttatatc tgcgtcactg ggggcgggtc     2700

ttttcttggc tccacccttt ttgacgtaga attcatgctc cacctcaacc acgtgatcct     2760

ttgcccaccg gaaaaagtct ttgacttcct gcttggtgac cttcccaaag tcatgatcca     2820

gacggcgggt gagttcaaat ttgaacatcc ggtcttgcaa cggctgctgg tgttcgaagg     2880

tcgttgagtt cccgtcaatc acggcgcaca tgttggtgtt ggaggtgacg atcacgggag     2940

tcgggtctat ctgggccgag gacttgcatt tctggtccac gcgcaccttg cttcctccga     3000

gaatggcttt ggccgactcc acgaccttgg cggtcatctt cccctcctcc caccagatca     3060

ccatcttgtc gacacagtcg ttgaagggaa agttctcatt ggtccagttg acgcagcaag     3120

ggcgaattcg tttaaacctg caggactagt ccctttagtg aggg                      3164


<210> 4849
<211> 3163
<212> DNA
<213> Adeno-associated virus

<400> 4849
accctcacta aagggactag tcctgcaggt ttaaacgaat tcgcccttgc tgcgtcaact       60

ggagcaatga gaactttccc ttcaacgact gtgtcgacaa gatggtgatt tggtgggagg      120

aggggaagat gaccgccaag gtcgtggagt cggccaaagc cattctcgga ggaagcaagg      180

tgcgcgtgga ccagaaatgc aagtcctcgg cccagataga tccgactccc gtgatcgtca      240

cctccaacac caacatgtgc gccgtgattg acgggaactc aacgaccttc gaacaccagc      300

agccgttgca agaccggatg ttcaaatttg aactcacccg ccgtctggat catgactttg      360

ggaaggtcac caagcaggaa gtcaaagact ttttccggtg ggcaaaggat cacgtggttg      420

aggtggagca tggattctac gtcaaaaagg gtggagccaa gaaaagaccc gcccctagtg      480

acgcagatat aagtgagccc aaacgggtgc gcgagtcagt tgcgcagcca tcgacgtcgg      540

acgcggaagc ttcgatcaac tacgcggaca ggtaccaaaa caaatgttct cgtcacgtgg      600

gcatgaatct gatgctgttt ccctgcagac aatgcgagag aatgaatcaa aattcaaata      660

tctgcttcac tcacggacag aaagactgtt tagagtgctt tcccgtgtca gaatctcaac      720

ctgtttctgt cgtcaaaaag gcgtatcaga aactgcgcta cattcatcat atcatgggaa      780

aggtgccaga cgcttgcact gcctgcgatc tggtcaatgt ggatttggat gactgcatct      840

ctgaacaata aatgatttaa atcaggtatg gctgccgatg gttatcttcc agattggctc      900

gaggacactc tctctgaagg aataagacag tggtggaagc tcaaacctgg cccaccacca      960

ccaaagcccg cagagcggca taaggacgac agcaggggtc ttgtgcttcc tgggtacaag     1020

tacctcggac ccttcaacgg actcgacaag ggagagccgg tcaacgaggc agacgccgcg     1080

gccctcgagc acgacaaggc ctacgaccgg cagctcgaca gcggagacaa cccgtacctc     1140

aagtacaacc acgccgacgc ggagtttcag gagcgtctta aagaagatac gtcttttggg     1200

ggcaacctcg gacgagcagt cttccaggcg aaaaagaggg ttcttgaacc tctgggcctg     1260

gttgaggaac ctgttaagac ggctccggga aaaaagaggc cggtagagca ctctcctgcg     1320

gagccagact cctcctcggg aaccggaaaa gcgggccagc agcctgcaag aaaaagactg     1380

aatttcggtc agactggaga cgcagactcc gtacctgacc cccagcctct cggacagcca     1440

ccagcagccc ccacaagttt gggatctact acaatggcta caggcagtgg cgcaccaatg     1500

gcagacaata acgagggtgc cgatggagtg ggtaattcct caggaaattg gcattgcgat     1560

tcccaatggc tgggcgacag agtcatcacc accagcaccc gaacctgggc cctgcccacc     1620

tacaacaacc acctttacaa gcaaatctcc agccaatcag gagcctcaaa cgacaaccac     1680

tactttggct acagcacccc ctgggggtat tttgacttca acagattcca ctgccacttt     1740

tcaccacgtg actggcaaag actcatcaac aacaactggg gattccgacc caagagactc     1800

aacttcaagc tctttaacat tcaagtcaaa gaggtcacgc agaatgacgg tacgacgacg     1860

attgccaata accttaccag cacggttcag gtgtttactg actcggagta ccagctcccg     1920

tacgtcctcg gctcggcgca tcaaggatgc ctcccgccgt ttccagcgga cgtcttcatg     1980

gtcccacagt atggatacct caccctgaac aacgggagtc aggcggtagg acgctcttcc     2040

ttttactgcc tggagtgctt tccttctcag atgctgcgta ctggaaacaa ctttcagttc     2100

agctacactt ttgaagacgt gcctttccac agcagctacg ctcacagcca gagtttggat     2160

cggctgatga atcctctgat cgaccagtac ctgtattatc taaacagaac acaaacagct     2220

agtggaactc agcagtctcg gctactgttt agccaagctg gacccacaag catgtctctt     2280

caagctaaaa actggctgcc tggaccgtgt tatcgccagc agcgtttgtc aaagcaggca     2340

aacgacaaca acaacagcaa ctttccctgg actggagcta ccaagtacca cctcaatggc     2400

agagactctt tggtgaaccc gggcccggcc atggccagcc acaaggacga tgaagaaaag     2460

tttttcccca tgcatggaac cctaatattt ggtaaagaag gaacaaatgc taccaacgcg     2520

gaattggaaa atgtcatgat tacagatgaa gaggaaatca ggaccaccaa tcccgtggct     2580

acagagcagt acggatatgt gtcaaataat ttgcaaaact caaatactgc tgcaagtact     2640

gaaactgtga atcaccaagg agcattacct ggtatggtgt ggcaggatcg agacgtgtac     2700

ctgcagggac ccatttgggc caagattcct cacaccgatg gacactttca tccttctcca     2760

ctgatgggag gttttggact caaacacccg cctcctcaga ttatgatcaa aaacactccc     2820

gttccagcca atcctcccac aaacttcagt tctgccaagt ttgcttcctt catcacacag     2880

tattccacgg gacaggtcag cgtggagatc gagtgggagc tgcagaagga gaacagcaaa     2940

cgctggaatc ccgaaattca gtacacttcc aactacaaca aatctgttaa tgtggacttt     3000

actgtggaca ctaatggtgt gtattcagag cctcgcccca ttggcaccag atacctgact     3060

cgtaatctgt aattgcttgt taatcaataa accgtttaat tcgtttcagt tgaactttgg     3120

tctctgcgaa gggcgaattc gcggccgcta aattcaattc gcc                       3163


<210> 4850
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4850
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Tyr Lys Gly Glu Pro 
    50                  55                  60                  


Val Asp Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Gly Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Arg Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Gly Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Leu Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asp Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Pro Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4851
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4851
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactctac      180

aagggagagc cggtcgacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga gggttcttga acctctgggc ttggttgggg agcctgttaa aacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggca accagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca gtggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggctctgccc acctacaata accacctcta caagcaaatc      780

tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgaccggca aagactcatc      900

aacaacaact ggggattccg accaaaaaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcggg gtaccagctc ccgtacgtcc tcggcttggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cctttgaaga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaatca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggacaatgt catgattaca     1680

gatgaagaag aaatccgcac caccaatccc gtggctacgg agcagtacgg atatgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactta tgggaggttt tggactcaaa     1920

cacccacctc ctcagatcat gattaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggaca agtcagcgtg     2040

gagatcgagt gggagctgca gaaggaggac agcaaacgct ggaaccccga gatccagtac     2100

acttccaact ataacaaacc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4852
<211> 3161
<212> DNA
<213> Adeno-associated virus

<400> 4852
cgaattgatt tagcggccgc gaattcgccc ttcgcagaga ccaaagttca actgaaacga       60

attaaacggt ttattgatta acaagcaatt acagattacg agtcaggtat ctggtgccaa      120

tggggcgagg ctctgaatac acaccattag tgtccacagt aaagtccaca ttaacagatt      180

tgttgtagtt ggaagtgtac tggatctcgg gattccagcg tttgctgttc tccttctgta      240

gctcccactc gatctccacg ctgacccgcc ccgtggaata ctgtgtgatg aaggaagcaa      300

actttgccgc actgaaggtg gtcgaaggat tcgcaggtac cggggtgttt ttgatgagaa      360

tctgtggagg agggtgttta agtccgaatc cgcccatgag gggagagggg tgaaaatgtc      420

cgtccgtgtg cggaatcttt gcccagatag gcccctgcag gtacacgtct ctgtcctgcc      480

agaccatgcc tggaagaacg ccttgtgtgt tgacatctgc agtagatgct tgtgtgttgc      540

cgctctggag gttggtagat acagaaccat actgctccgt ggccacggga ttggtggttc      600

tgatttcctc ttcgtctgta atcatgacct tttcaatgtc cacatttgtt ttctctgatc      660

cttgttttcc aaagatgaga accccgctct gaggaaaaaa cttttcttca tcgtccttgt      720

ggctggccat tgccgggccc ggattcacca gagagtctct gccattgagg tggtacttgg      780

tagctccaat ccacgagtat tcactgttgt tgttgtccgc agatgtcttt gatactcgct      840

gctggcggta acagggtcca ggaagccagt tcctagactg atcccgaatg tcactcgctc      900

cggcctgaga aaactgaagc ctggactgcg tggtggttcc gcttggagtg tttgttctgc      960

tcaagtaata caggtactgg tcgatgagag gattcatgag acggtccaaa ctctggctgt     1020

gagcgtagct gctgtggaaa ggaacatcct caaaggtgta gctgaaggta aagttgtttc     1080

cggtacgcag catctgagaa gggaagtact ccaggcagta aaatgaagag cgtcctactg     1140

cctgactccc gttgttcagg gtgaggtatc catactgtgg caccatgaag acgtctgctg     1200

ggaacggcgg gaggcatcct tgatgcgccg agccgaggac gtacgggagc tggtactccg     1260

agtcagtaaa cacctgaacc gtgctggtaa ggttattggc aatcgtcgtc gtaccatcat     1320

tctgcgtgac ctctctgact tgaatgttaa agagcttgaa gttgagtctc ttgggccgga     1380

atccccagtt gttgttgatg agtctttgcc agtcacgtgg tgaaaagtgg cagtggaatc     1440

tgttgaagtc aaaatacccc caaggggtgc tgtagccaaa gtagtggttg tcgttgctgg     1500

ctcctgattg gctggaaatc tgcttgtaca gatggttgtt gtaggtgggc agagcccagg     1560

ttcgggtgct ggtggtgatg actctgtcgc ccatccatgt ggaatcgcaa tgccaatttc     1620

ccgaggaatt acccactccg tcggcgccat cgttattgtc tgccattggt gcgccactgc     1680

ctgtagccat cgtattagtt cccagaccag agggggctgc tggtggctgt ccgagaggct     1740

gggggtcagg tacggagtct gcgtctccag tctgaccgaa attcaatctc tttcttgcag     1800

gctggttgcc cgcttttccg gttcccgagg aggagtctgg ctccacagga gagtgctcta     1860

ccggcctctt ttttcccgga gccgtcttaa caggctcctc aaccaggccc agaggttcaa     1920

gaaccctctt ttttgcctgg aagactgctc gtccgaggtt gcccccaaaa gacgtatctt     1980

ctttaaggcg ctcctgaaac tccgcgtcgg cgtggtcgta cttgaggtac gggttgtctc     2040

cgctgtcgag ctgccggtcg taggccttgt cgtgctcgag ggccgcggcg tctgcctcgt     2100

tgaccggctc tcccttgtcg agtccgttga agggtccgag gtacttgtac ccaggaagca     2160

caagacccct gctgtcgtcc ttatgccgct ctgcgggctt tggtggtggt gggccaggtt     2220

tgagcttcca ccactgtctt attccttcag agagagtgtc ctcgagccaa tctggaagat     2280

aaccatcggc agccatacct gatttaaatc atttattgtt cagagatgca gtcatccaaa     2340

tccacattga ccagatcgca ggcagtgcaa gcgtctggca cctttcccat gatatgatga     2400

atgtagcaaa gtttctgata cgcctttttg acgacagaaa cgggttgaga ttctgacacg     2460

ggaaagcact ctaaacagtc tttctgtccg tgagtgaagc agatatttga attctgattc     2520

attctctcgc attgtctgca gggaaacagc atcagattca tgcccacgtg acgagaacat     2580

ttgttttggt acctgtccgc gtagttgatc gaagcttccg cgtctgacgt cgatggctgc     2640

gcaactgact cgcgcgcccg tttgggctca cttatatctg cgtcactggg ggcgggtctt     2700

ttcttggctc cacccttttt gacgtagaat tcatgctcca cctcaaccac gtgatccttt     2760

gcccaccgga aaaagtcttt cacttcctgc ttggtgacct tcccaaagtc atgatccaga     2820

cggcgggtta gttcaaattt gaacatccgg tcttgcaacg gctgctggtg ttcgaaggtc     2880

gttgagttcc cgtcaatcac ggcgcacatg ttggtgttgg aggtggcgat cacgggagtc     2940

gggtctatct gggccgagga cttgcacttt tggtccacgc gcaccttgct tcctccgaga     3000

atggcttcgg ccgattccac gaccttggcg gtcatctttc cctcctccca ccagatcacc     3060

atcttgtcga cacagtcgtt gaagggaaag ttctcattgg tccagttgac gcagcaaggg     3120

cgaattcgtt taaacctgca ggaactagtc ccttagtgag g                         3161


<210> 4853
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4853
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Tyr Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Gly Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asp Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4854
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4854
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccgccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactctac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccgg cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga gggttcttga acctctgggc ttggttgagg agcctgttaa aacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggca accagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca gtggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggctctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg accaaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cctttgaaga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaatca aatagtggaa cccttcagca gtctcggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggacaatgt catgattaca     1680

gatgaagaag aaatccgcac caccaatccc gtggctacgg agcagtacgg atatgtgtca     1740

aataatttgc aagactcaaa tactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactta tgggaggttt tggactcaaa     1920

cacccacctc ctcagatcat gattaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggaca agtcagcgta     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaaccccga gatccagtac     2100

acttccaact ataacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4855
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4855
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Cys Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Pro Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Arg Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4856
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 4856
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctgc aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagacag gccagcagcc cgcgaaaaag agactcaact ttgggcagac tggcgactca      540

gagtcagtgc ccgaccctca accaatcgga gaaccccccg caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctc cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcaacttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtctttac ggactcggaa taccagctcc cgtacgtcct cggctctgcg     1080

caccagggct gcccgcctcc gttcccggcg gacgtcttca tgattcctca gtacgggtac     1140

ctgactctga acaacggcag tcaggccgtg ggccgttcct ccttctactg cctggagtac     1200

tttccttctc aaatgcggag aacgggcaac aactttgagt tcagctacca gtttgaggac     1260

gtgccttttc acagcagcta cgcgcatagc caaagcctgg accggctgat gaaccccctc     1320

atcgaccagt acctgtacta cctgtctcgg actcagtcca cgggaggtac cgcaggaact     1380

cagcagttgc tattttctca ggccgggcct aataacatgt cggctcaggc caaaaactgg     1440

ctacccgggc cctgctaccg gcagcaacgc gtctccacga cactgtcgca aaataacaac     1500

agcaactttg cttggaccgg tgccaccaag tatcatctga atggcagaga ctctctggta     1560

aatcccggtg tcgctatggc aacgcacaag gacgacgaag agcgattttt tccatccagc     1620

ggagtcttga tgtttgggaa acagggagct ggaaaagaca acgtggacta tagcagcgtt     1680

atgctaacca gtgaggaaga aatcaaaacc accaacccag tggccacaga acagtacggc     1740

gtggtggccg ataacctgca acagcaaaac gccgctccta ttgtaggggc cgtcaacagt     1800

caaggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatc     1860

tgggccaaga ttcctcacac ggacggcaac tttcatcctt cgccgctgat gggaggcttt     1920

ggactgaaac acccgcctcc tcagatcctg attaagaata cacctgttcc cgcggatcct     1980

ccaactacct tcagtcaagc caagctggcg tcgttcatca cgcagtacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaagagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta taacaaatct gttaatgtgg actttactgt ggacactaat     2160

ggtgtgtatt cagagcctcg ccccattggc accagatacc tgactcgtaa tctgtaa        2217


<210> 4857
<211> 3167
<212> DNA
<213> Adeno-associated virus

<400> 4857
attgaattta gcggccgcga attcgccctt cgcagagacc aaagttcaac tgaaacgaat       60

taaacggttt attgattaac aagcaattac agattacgag tcaggtacct ggtgccaatg      120

gggcgaggct ctgaatacac accattagtg tccacagtaa agtccacatt aacagatttg      180

ttgtagttgg aagtgtactg aatctcggga ttccagcgtt tgctgttctc cttctgcagc      240

tcccactcga tctccacgct gacctgcccc gtggagtact gtgtaatgaa ggaagcaaac      300

tttgccgcac tgaaggtagt cgaaggattc gcaggtaccg gggtgttctt gatgagaatc      360

tgcgggggag ggtgtttaag tccgaatccg cccatgaggg gagaggggtg aaaatgtccg      420

tccgtgtgtg gaatctttgc ccagatgggc ccctgcaggt acacgtctct gtcctgccac      480

accatgcctg gaagaacgcc ttgtgtgttg acatctgagg tagctgcttg tgtgttgccg      540

ctctggaggt tggtagatac agaaccatac tgctccgtag ccacgggatt ggtggtcctg      600

atttcctctt cgtctgtaat catgaccttt tcaatgtcca cattagtttt tcccgagtct      660

tgttttccaa agatgagaac cccgctctga ggaaaaaact tttcttcatc gtccttgtgg      720

ctggccatgg ccgggcccgg attcaccaga gagtctcttc cattaaggtg gtacttggta      780

gctccagtcc acgagtattc actgttgttg ttatccgcag atgtctttga tactcgctgc      840

tggcggtaac agggtccagg aagccagttc ctagactggt cccgaatgtc acttgctccg      900

gcctgagaaa actgaagcct tgactgcgtg gtggttccgc ttggagtgtt tgttctgctc      960

aagtaataca ggtactggtc gatgagagga ttcatgagac ggtccaaact ctggctgtgg     1020

gcgtagctgc tgtggaaagg aacgtcctca aaggtgtagc tgaaggtaaa gttgtttccg     1080

gtacgcagca tctgagaagg aaagtactcc aggcagtaaa atgaagagcg tcctactgcc     1140

tgactcccgt tgttcagggt gaggtatcca tactgtggca ccatgaagac gtctgctggg     1200

aacggcggga ggcatccttg atgcgccgag ccgaggacgt acgggagctg gtactccgag     1260

tcagtaaaca cctgaaccgt gctggtaagg ttattggcaa tcgtcgtcgt accgtcattc     1320

tgcgtgacct ccttgacttg aatgttaaag agcttgaagt tgagtctttt gggccggaat     1380

ccccaattgt tgttgatgag tctttgccag tcacgtggcg aaaagtggca gtggaatctg     1440

ttgaagtcaa aataccccca aggggtgctg tagccaaagt agtggttgtc gtttgaggct     1500

cctgattggc tggaaatctg cttgtagagg tggttgttgt aggtgggcag agcccaggtg     1560

cgggtgctgg tggtgatgac tctgtcgccc atccatgtgg aatcgcaatg ccaatttccc     1620

gaggaattac ccactccgtc ggcgccctcg ttattgtctg ccattggtgc gccactgcct     1680

gtagccatcg tattagttcc cagaccagag ggggctgctg gtggctgtcc gagaggctgg     1740

gggtcaggta cggagtctgc gtctccagtc tgaccgaaat tcaatctctt tcttgcaggc     1800

tgctggcccg cttttccggt tcccgaggag gagtctggct ccgcaggaga gtgctctacc     1860

ggcctctttt ttcccggagc cgtcttaaca ggttcctcaa ccaggcccag aggttcaaga     1920

accctctttt tcgcctggaa gactgctcgt ccgaggttgc ccccaaaaga cgtatcttct     1980

ttaagacgct cctggaactc cgcgtcggcg tggttgtact tggggtacgg gttgtctccg     2040

ctgtcgagct gccggtcgta ggccttgtcg tgctcgaggg ccgcggcgtc tgcctcgttg     2100

accggctctc ccttgtcgag tccgttgaag ggtccaaggt acttgtaccc aggaagcaca     2160

agacccctgc tgtcgtcctt atgccgctct gcgggctttg gtggtggtgg gccaggtttg     2220

agcttccacc actgtcttat tccttcagag agagtgtcct cgagccaatc tggaagataa     2280

ccatcggcag ccatacctga tttaaatcat ttattgttca gagatgcagt catccaaatc     2340

cacattgacc agatcgcaag cagtgcaagc gtctggcacc tttcccatga tatgatgaat     2400

gtagcacagt ttctgatacg cctttttgac gacagaaacg ggttgagatt ctgacacggg     2460

aaagcactct aaacagtctt tctgtccgtg agtgaagcag atatttgaat tctgattcat     2520

tctctcgcat tgtctgcagg gaaacagcat cagattcatg cccacgtgac gagaacattt     2580

gttttggtac ctgtccgcgt agttgattga agcttccgcg tctgacgtcg atggctgcgc     2640

aactgactcg cgcgcccgtt tgggctcact tatatctgcg tcactggggg cgggtctttt     2700

tttggctcca ccctttttga cgtagaattc atgctctacc tcaaccacgt gatcctttgc     2760

ccaccggaaa aagtctttga cttcctgctt ggtgaccttc ccaaagtcat gatccagacg     2820

gcgggtgagt tcaaatttga acatccggtc ttgcaacggc tgctggtgtt cgaaggtcgt     2880

tgagttcccg tcaatcactg cgcacatgtt ggtgttggag gtgacaatca cgggagtcgg     2940

gtctatctgg gccgaggact tgcatttctg gtccacgcgc accttgcttc ctccgagaat     3000

ggctttggcc gactccacga ccttggcggt catcttcccc tcctcccacc agatcaccat     3060

cttgtcgacg caatcattga aaggaaagtt ctcattggtc cagttgacgc agccgtagaa     3120

agggcgaatt cgtttaaacc tgcaggacta gtccctttag tgagggt                   3167


<210> 4858
<211> 3161
<212> DNA
<213> Adeno-associated virus

<400> 4858
aattgaattt agcggccgcg aattcgccct tcgcagagac caaagttcaa ctgaaacgaa       60

ttaaacggtt tattgattaa caagcaatta cagattacga gtcaggtatc tggtgccaat      120

ggggcgaggc tctgaataca caccattagt gtccacagta aagtccacat taacagattt      180

gttgtagttg gaagtgtact gaatctcggg attccagcgt ttgctgttct ccttctgcag      240

ctcccactcg atctccacgc tgacctgccc cgtggagtac tgtgtaatga aggaagcaaa      300

ctttgccgca ctgaaggtag tcgaaggatt cgcaggtacc ggggtgttct tgatgagaat      360

ctgcggggga gggtgtttaa gtccgaatcc gcccatgagg ggagaggggt gaaaatgtcc      420

gtccgtgtgt ggaatctttg cccagatggg cccctgcagg tacacgtctc tgtcctgcca      480

caccatgcct ggaagaacgc cttgtgtgtt gacatctgag gtagctgctt gtgtgttgcc      540

gctctggagg ttggtagata cagaaccata ctgctccgta gccacgggat tggtggtcct      600

gatttcctct tcgtctgtaa tcatgacctt ttcaatgtcc acattagttt ttcccgagtc      660

ttgttttcca aagatgagaa ccccgctctg aggaaaaaac ttttcttcat cgtccttgtg      720

gctggccatg gccgggcccg gattcaccag agagtctctt ccattaaggt ggtacttggt      780

agctccagtc cacgagtatt cactgttgtt gttatccgca gatgtctttg atactcgctg      840

ctggcggtaa cagggtccag gaagccagtt cctagactgg tcccgaatgt cacttgctcc      900

ggcctgagaa aactgaagcc ttgactgcgt ggtggttccg cttggagtgt ttgttctgct      960

caagtaatac aggtactggt cgacgagagg attcatgaga cggtccaaac tctggctgtg     1020

ggcgtagctg ctgtggaaag gaacgtcctc aaaggtgtag ctgaaggtaa agttgtttcc     1080

ggtacgcagc atctgagaag gaaagtactc caggcagtaa aatgaagagc gtcctactgc     1140

ctgactcccg ttgttcaggg tgaggtatcc atactgtggc accatgaaga cgtctgctgg     1200

gaacggcggg aggcatcctt gatgcgccga gccgaggacg tacgggagct ggtactccga     1260

gtcagtaaac acctgaaccg tgctggtaag gttattggca atcgtcgtcg taccgtcatt     1320

ctgcgtgacc tccttgactt gaatgttaaa gagcttgaag ttgagtcttt tgggccggga     1380

tccccaattg ttgttgatga gtctttgcca gtcacgtggc gaaaagtggc agtggaatct     1440

gttgaagtca aaataccccc aaggggtgct gtagccaaag tagtggttgt cgtttgaggc     1500

tcctgattgg ctggaaatct gcctgtagag gtggttgttg taggtgggca gagcccaggt     1560

gcgggtgctg gtggtgatga ctctgtcgcc catccatgtg gaatcgcaat gccaatttcc     1620

cgaggaatta cccactccgt cggcgccctc gttattgtct gccattggtg cgccactgcc     1680

tgtagccatc gtattagttc ccagaccaga gggggctgct ggtggctgtc cgagaggctg     1740

ggggtcaggt acggagtctg cgtctccagt ctgaccgaaa ttcaatctcc ttcttgcagg     1800

ctgctggccc gcttttccgg ttcccgagga ggagtctggc tccgcaagag agtgctctac     1860

cggcctcttt tttcccggag ccgtcttaac aggttcctca accaggccca gaggttcaag     1920

aaccctcttt ttcgcctgga agactgctcg tccgaggttg cccccaaaag acgtatcttc     1980

tttaagacgc tcctggaact ccgcgtcggc gtggttgtac ttgaggtacg ggttgtctcc     2040

gccgtcgagc tgccggtcgt aggccttgtc gtgctcgagg gccgcggcgt ctgcctcgtt     2100

gaccggctct cccttgtcga gtccgttgaa gggtccaagg tacttgtacc caggaagcac     2160

aagacccctg ctgtcgtcct tatgccgctc tgcgggcttt ggtggtggtg ggccaggttt     2220

gagcttccac cactgtctta ttccttcaga gagagtgtcc tcgagccaat ctggaagata     2280

accatcggca gccatacctg atttaaatca tttattgttc agagatgcag tcatccaaat     2340

ccacattgac cagatcgcaa gcagtgcaag cgtctggcac ctttcccatg atatgatgaa     2400

tgtagcacag tttctgatac gcctttttga cgacagaaac gggttgagat tctgacacgg     2460

gaaagcactc taaacagtct ttctgtccgt gagtgaagca gatatttgaa ttctgattca     2520

ttctctcgca ttgtctgcag ggaaacagca tcagattcat gcccacgtga cgagaacatt     2580

tgttttggta cctgtccgcg tagttgattg aagcttccgc gtctgacgtc gatggctgcg     2640

caactgactc gcgcgcccgt ttgggctcac ttatatctgc gtcactgggg gcgggtcttt     2700

ttttggctcc accctttttg acgtagaatt catgctctac ctcaaccacg tgatcctttg     2760

cccaccggaa aaagtctttg acttcctgct tggtgacctt cccaaagtca tgatccagac     2820

ggcgggtgag ttcaaatttg aacatccggt cttgcaacgg ctgctggtgt tcgaaggtcg     2880

ttgagttccc gtcaatcact gcgcacatgt tggtgttgga ggtgacaatc acgggagtcg     2940

ggtctatctg ggccgaggac ttgcatttct ggtccacgcg caccttgctt cctccgagaa     3000

tggctttggc cgactccacg accttggcgg tcatcttccc ctcctcccac cagatcacca     3060

tcttgtcgac gcaatcattg aaaggaaagt tctcattggt ccagttgacg cagcaagggc     3120

gaattcgttt aaacctgcag gactagtccc tttagtgagg g                         3161


<210> 4859
<211> 3172
<212> DNA
<213> Adeno-associated virus

<400> 4859
gattgaattt agcggccgcg aattcgccct tgctgcgtca actggaccaa tgagaacttt       60

cccttcaacg attgcgtcga caagatggtg atctggtggg aggagggcaa gatgaccgcc      120

aaggtcgtgg agtccgccaa ggccattctg ggtggaagca aggtgcgcgt ggaccaaaag      180

tgcaagtcat cggcccagat cgaccccacg cccgtgatcg tcacctccaa caccaacatg      240

tgcgccgtga tcgacgggaa cagcaccacc ttcgagcacc agcagcccct gcaggaccgc      300

atgttcaagt tcgagctcac ccgccgtctg gagcacgact ttggcaaggt gaccaagcag      360

gaagtcaaag agttcttccg ctgggctcag gatcacgtga ctgaggtggc gcatgagttc      420

tacgtcagaa agggcggagc caccaaaaga cccgccccca gtgacgcgga tataagcgag      480

cccaagcggg cctgcccctc agttgcggag ccatcgacgt cagacgcgga agcaccggtg      540

gactttgcgg acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg      600

tttccctgca agacatgcga gagaatgaat cagaatttca acgtctgctt cacgcacggg      660

gtcagagact gctcagagtg cttccccggc gcgtcggaat ctcaacccgt cgtcagaaaa      720

aagacgtatc agaaactgtg cgcgattcat catctgctgg ggcgggcacc cgagattgcg      780

tgttcggcct gcgatctcgt caacgtggac ttggatgact gtgtttctga gcaataaatg      840

acttaaacca ggtatggctg ctgacggtta tcttccagat tggctcgagg acaacctctc      900

tgagggcatt cgcgagtggt gggacctgaa acctggagcc cccaagccca aggccaacca      960

gcagaagcag gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt     1020

caacggactc gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga     1080

caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc     1140

cgacgccgag tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg     1200

agcagtcttc caggccaaga agcgggttct cgaacctctc ggtctggttg aggaagctgc     1260

taagacggct cctggaaaga agagaccggt agaaccgtca cctcagcgtt cccccgactc     1320

ctccgcgggc atcggcaaga aaggccagca gcccgctaaa aagagactga actttggtca     1380

gactggcgac tcagagtcag tccccgaccc tcaaccaatc ggagaaccac cagcaggccc     1440

ctctggtctg ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa     1500

cgaaggcgcc gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct     1560

gggcgacaga gtcatcacca ccagcacccg aacctgggcc ctgcccacct acaacaacca     1620

cctctacaag caaatatcca atgggacatc gggaggaagc accaacgaca acacctactt     1680

cggctacagc accccctggg ggtattttga cttcaacaga ttccactgcc acttctcacc     1740

acgtgactgg cagcgactca tcaacaacaa ctggggattc cggccaaaaa gactcagctt     1800

caagctcttc aacatccagg tcaaggaggt cacgcagaat gaaggcaccg agaccatcgc     1860

caataacctt accagcacga ttcaggtatt tacggactcg gaataccagc tgccgtacgt     1920

cctcggctcc gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc     1980

ccagtacggc taccttacac tgaacaatgg aagtcaagcc gtaggccgtt cctccttcta     2040

ctgcctggaa tattttccat ctcaaatgct gcgaactgga aacaattttg aattcagcta     2100

caccttcgag gacgtgcctt tccacagcag ctgcgcacac agccagagct cggaccgact     2160

gatgaatcct ctcatcgacc agtacctgta ctacttatcc agaactcggt ccacaggagg     2220

aactcaaggt acccagcaat tgttattttc tcaagctggg cctgcaaaca tgtcggctca     2280

ggctaagaac tggctacctg gaccttgcta ccggcagcag cgagtctcta cgacactgtc     2340

gcaaaacaac aacagcaact ttgcttggac tggtgccacc aaatatcacc tgaacggaag     2400

agactctttg gtaaatcccg gtgtcgccat ggcaacccac aaggacgacg aggaacgctt     2460

cttcccgtcg agtggagtcc tgatgtttgg aaaacagggt gctggaagag acaatgtgga     2520

ctacagcagc gttatgctaa ccagcgaaga agaaattaaa accactaacc ctgtagccac     2580

agaacaatac ggtgtggtgg ctgacaactt gcagcaaacc aatacagggc ctattgtggg     2640

aaatgtcaac agccaaggag ccttacctgg catggtctgg cagaaccgag acgtgtacct     2700

gcagggtccc atctgggcca agattcctca cacggacggc aacttccacc cttcaccgct     2760

aatgggagga tttggactga agcacccacc tcctcagatc ctgatcaaga acacgccggt     2820

acctgcggat cctccaacaa cgttcagcca ggcgaaattg gcttccttca ttacgcagta     2880

cagcaccgga caggtcagcg tggaaatcga gtgggagctg cagaaggaga acagcaaacg     2940

ctggaaccca gagattcagt acacttcaaa ctactacaaa tctacaaatg tggactttgc     3000

tgtcaataca gagggaactt attctgagcc tcgccccatt ggtactcgtt acctcacccg     3060

taatctgtaa ttgctggtta atcaataaac cgtttgattc gtttcagttg aactttggtc     3120

tctgcgaagg gcgaattcgt ttaaacctgc aggactagtc cctttagtga gg             3172


<210> 4860
<211> 3172
<212> DNA
<213> Adeno-associated virus

<400> 4860
gattgaattt agcggccgcg aattcgccct tgctgcgtca actggaccaa tgagaacttt       60

cccttcaacg attgcgtcga caagatggtg atctggtggg aggagggcaa gatgaccgcc      120

aaggtcgtgg agtccgccaa ggccattctg ggtggaagca aggtgcgcgt ggaccaaaag      180

tgcaagtcat cggcccagat cgaccccacg cccgtgatcg tcacctccaa caccaacatg      240

tgcgccgtga tcggcgggaa cagcaccacc ttcgagcacc agcagcccct gcaggaccgc      300

atgttcaagt tcgagctcac ccgccgtctg gagcacgact ttggcaaggt gaccaagcag      360

gaagtcaaag agttcttccg ctgggctcag gatcacgtga ctgaggtggc gcatgagttc      420

tacgtcagaa agggcggagc caccaaaaga cccgccccca gtgacgcgga tataagcgag      480

cccaagcggg cctgcccctc agttgcggag ccatcgacgt cagacgcgga agcaccggtg      540

gactttgcgg acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg      600

tttccctgca agacatgcga gagaatgaat cagaatttca acgtctgctt cacgcacggg      660

gtcagagact gctcagagtg cctccccggc gcgtcagaat ctcaacccgt cgtcagaaaa      720

aagacgtatc agaaactgtg cgcgattcat catctgctgg ggcgggcacc cgagattgcg      780

tgttcggcct gcgatctcgt caacgtggac ttggatgact gtgtttctga gcaataaatg      840

acttaaacca ggtatggctg ctgacggtta tcttccagat tggctcgagg acaacctctc      900

tgagggcatt cgcgagtggt gggacctgaa acctggagcc cccaagccca aggccaacca      960

gcagaagcag gacgacggcc ggggtctggt gcttcttggc tacaagtacc tcggaccctt     1020

caacggactc gacaaggggg agcccgtcaa tgcggcggac gcagcggccc tcgagcacga     1080

caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc     1140

cgacgccgag tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg     1200

agcagtcttc caggccaaga agcgggttct cgaacctctc ggtctggttg aggaagctgc     1260

taagacggct cctggaaaga agagaccggt agaaccgtca cctcagcgtt cccccgactc     1320

ctccacgggc atcggcaaga aaggccagca gcccgctaaa aagagactga actttggtca     1380

gactggcgac tcagagtcag tccccgaccc tcaaccaatc ggagaaccac cagcaggccc     1440

ctctggtctg ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa     1500

cgaaggcgcc gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct     1560

gggcgacaga gtcatcacca ccagcacccg aacctgggcc ctgcccacct acaacaacca     1620

cctctacaag caaatatcca atgggacatc gggaggaagc accaacgaca acacctactt     1680

cggctacagc accccctggg ggtattttga cttcaacaga ttccactgcc acttctcacc     1740

acgtgactgg cagcgactca tcaacaacaa ctggggattc cggccaaaaa gactcagctt     1800

caagctcttc aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc     1860

caataacctt accagcacga ttcaggtatt tacggactcg gaataccagc tgccgtacgt     1920

cctcggctcc gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc     1980

ccagtacggc taccttacac tgaacaatgg aagtcaagcc gtaggccgtt cctccttcta     2040

ctgcctggaa tattttccat ctcaaatgct gcgaactgga aacaattttg aattcagcta     2100

caccttcgag gacgtgcctt tccacagcgg ctacgcacac agccagagct tggaccgact     2160

gatgaatcct ctcatcgacc agtacctgta ctacttatcc agaactcagt ccacaggagg     2220

aactcaaggt acccagcaat tgttattttc tcaagctggg cctgcaaaca tgtcggctca     2280

ggctaagaac tggctacctg gaccttgcta ccggcagcag cgagtctcta cgacactgtc     2340

gcaaaacaac aacagcaact ttgcttggac tggtgccacc aaatatcacc tgaacggaag     2400

agactctttg gtaaatcccg gtgtcgccat ggcaacccac aaggacgacg aggaacgctt     2460

cttcccgtcg agtggagtcc tgatgtttgg aaaacagggt gctggaagag acaatgtgga     2520

ctacagcagc gttatgctaa ccagcgaaga agaaattaaa accactaacc ctgtagccac     2580

agaacaatac ggtgtggtgg ctgacaactt gcagcaaacc aatacagggc ctattgtggg     2640

aaatgtcaac agccaaggag ccttacctgg catggtctgg cagaaccgag acgtgtacct     2700

gcagggtccc atctgggcca agattcctca cacggacggc aacttccacc cttcaccgct     2760

aatgggagga tttggactga agcacccacc tcctcagatc ctgatcaaga acacgccggt     2820

acctgcggat cctccaacga cgttcagcca ggcgaaattg gcttccttca ttacgcagta     2880

cagcaccgga caggtcagcg tggaaatcga gtgggagctg cagaaggaga acagcaaacg     2940

ctggaaccca gagattcagt acacttcaaa ctactacaaa tctacaaatg tggactttgc     3000

tgtcaataca gagggaactt attctgagcc tcgccccatt ggtactcgtt acctcacccg     3060

taatctgtaa ttgctggtta atcaataaac cgtttgattc gtttcagttg aactttggtc     3120

tctgcgaagg gcgaattcgt ttaaacctgc aggactagtc cctttagtga gg             3172


<210> 4861
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4861
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg aaagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg agcctgttaa aacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc gagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg cttcaggcag tggcgcacca gtggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacagct ggggattccg acccaaaaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caagtgttta ccgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttt atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cctttgaaga cgttcccttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctgc tgaatcctct gatcgaccag     1320

tacctatatt atctgaacaa gacacaatca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggacaatgt catgattaca     1680

gatgaagaag aaatccgcac caccaatccc gtggctacgg agcagtacgg atatgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca cggacgggca ctttcatcct tctccactaa tgggaggttt tgggctcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcctacaaac     1980

ttcagttctt ccaagtttgc ttctttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtat     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ccgactcgta atctgtaa                  2208


<210> 4862
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4862
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Glu Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Ser Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Leu Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ser Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Pro Thr Arg Asn Leu 
                725                 730                 735 


<210> 4863
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4863
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggagaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gccagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggtattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctcg tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4864
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4864
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Glu Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp Tyr Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Val Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4865
<211> 2209
<212> DNA
<213> Adeno-associated virus

<400> 4865
atggctgccg atggttatcc tccagattgg ctcgaggaca ctctctctga agggataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcagagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcggcctgc aagaaaaaga ttaaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acatacaaca accacctcta caagcaaatc      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaaaaga ctcaacttca agctctttaa tattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tgggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cttttgaaga cgtgcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc aaccaacatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaaa caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cagctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa ggatgacgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt catgattaca     1680

gatgaagaag aaatcagggc caccaatccc gtggctacgg agcagtacgg gactgtgtca     1740

aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatcg ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaat                 2209


<210> 4866
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4866
Met Ala Ala Asp Gly Tyr Pro Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Arg Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Ala Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn Arg Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4867
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4867
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aggtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgtcga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa ggcggctccg      420

ggagaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

cattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccccca tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg cgccagatac ctgactcgta atctgtaa                  2208


<210> 4868
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4868
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Arg Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Val 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Ala Ala Pro Gly Glu Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly His Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Pro Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Ala Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4869
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4869
atggctgccg atggttatct tccagattgg ctcgaggaca ccctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga taacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagagga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccggcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4870
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4870
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Arg Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4871
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4871
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaaggaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcgg cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagacgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4872
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4872
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Gly Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Gly Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Thr Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4873
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4873
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctgcaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ttttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

acctacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc gggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt tggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4874
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4874
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Cys Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Tyr Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Arg Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4875
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4875
atggctgccg atggttatct tccagattgg ctcgaggaca ccctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga taacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagagga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccggcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4876
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4876
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Arg Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4877
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4877
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

ggcagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctca acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcaaaaaaga gggttcttga acctctgggc ctggttgagg agcctgttaa aacggctccg      420

ggaaaaaaga gaccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accacaagca ctcgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc aaacgacaac cactattttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct cccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cttttgaaga cgtgcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc caccaacatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cagctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa ggatgacgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt catgattaca     1680

gatgaagaag aaatcaggac caccaatccc gtggctacgg agcagtacgg gactgtgtca     1740

aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagat gtgtaccttc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcagattat gatcaaaaac actcccgttc cagccaatcc tcctacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacaataa tggcgtgtac     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4878
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4878
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Gly Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asn Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Pro Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Asn Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4879
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4879
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4880
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4880
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4881
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4881
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tatttcgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcggg gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgccttccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacgg ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacgtt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

gtctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gcggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgt ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4882
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4882
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Gly Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Gly Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Val Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Val Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Ala Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Val Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4883
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4883
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga aactcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcaaaaaaga gggttctgga acctctgagc ctggttgagg agcctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctccc gcagagccag attcctcctc cggaactgga      480

aagtcgggca accagcctgc aagaaagaga ttgaatttcg gtcagactgg agactcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accatctgta caagcaaata      780

tccagccagt ctggagccag caacgacaat cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctagagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtccaggctt     1380

cagttttctc aggccggagc gagtgacatt caggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gtcagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa agacgatgaa gaaaagtttt ttcctcagag cggggttctt     1620

atctttggga agcaaggctc agagaaaaca aatgtggata ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtcgggca agacagagac gtgtacctgc aggggcctac ttgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt tggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatt acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga gatccagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4884
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4884
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Ser Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Gln Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Gly Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Thr Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4885
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4885
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcagagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcaaaaaaga gggttctgga acctctgggc ctggttgagg agcctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcagagccag attcctcctc cggaactgga      480

aagtcgggca accagcctgc aagaaagaga ttgaatttcg gtcagactgg agactcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accatctgta caagcaaata      780

tccagccagt ctggagccag caacgacaat cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctagggta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtccaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gtcagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa agacgatgaa gaaaagtttt ttcctcagag cggggttctt     1620

atctttggga agcaaggccc agagaaaaca aatgtggata ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca agacagagac gtgtacctgc aggggcctat ttgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt tggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatt acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga gatccagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4886
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4886
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Gly Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Pro Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4887
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4887
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Pro Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4888
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4888
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Pro Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4889
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 4889
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcagagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgcgg cctggtttga ggaaacctgt taagacggct      420

ccgggaaaaa agaggccggt agagcactct cctgtggagc cagactcctc ctcgggaacc      480

ggaaaagcgg gccagcagcc tgcaagaaaa agattaaatt ttggtcagac tggagacgca      540

gactccgtac ctgaccccca gcctctcgga cagccaccag cagccccctc tggtctggga      600

tctactacaa tggctacagg cagtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctgga cgacagagtc      720

atcgccacca gcacccgaac ctgggccctg cccacataca acaaccacct ctacaagcaa      780

atctccagcc aatcaggagc ctgcaacgac aaccactact ttggctacag caccccctgg      840

gggtattttg acttcaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacagca actggggatt ccggcccaaa agactcaact tcaagctctt taatattcaa      960

gtcaaagagg tcacgcagaa tgacggtacg acgacgattg ccaataacct taccagcacg     1020

gttcaggtgt ttactgactc ggagtaccag ctcccgtacg tcccgggctc ggcgcatcaa     1080

ggatgcctcc cgccgtttcc agcggacgtc ttcatggtcc cacagtatgg atacctcacc     1140

ctgaacaacg ggagtcaggc ggtaggacgc tcttcctttt actgcctgga gtactttcct     1200

tctcagatgc tgcgtactgg aaacaacttt cagttcagct acacttttga agacgtgcct     1260

ttccacagca gctacgctca ctgccagagt ctggatcggc tgatgaatcc tctgatcgac     1320

cagtacctgt attatctgaa caagacacaa acaaatagtg gaactcttca gcagtctcgg     1380

ctactgttta gccaagctgg accaaccaac atgtctcttc aagctaaaaa ctggctgcct     1440

ggaccttgct acagacagca gcgtctgtca aaacaggcaa acgacaataa caactgcaac     1500

tttccctgga ctgcagctac aaagtatcat ctaaatggcc gggactcgtt ggttaatcca     1560

ggaccagcta tggccagtca caaggatgac gaagaaaagt ttttccccat gcatggaacc     1620

ctgatatttg gtaaacaagg aacaaatgcc aacgacgcgg atttggaaaa tgtcatgatt     1680

acagatgaag aagaaatcag gcccaccaat cccgtggcta cggagcagta cgggactgtg     1740

tcaaataatt tgcaaaactc aaacactggt ccaactacag gaactgtcaa tcaccaagga     1800

gcgttacctg gtatggtgtg gcaggatcga gacgtgtacc tgcagggacc catttgggcc     1860

aagattcctc acaccgatgg acactttcat ccttctccac tgatgggagg ttttggactc     1920

aaacacccgc ctcctcagat catgatcaaa agcactcccg ttccagccaa tcctcccaca     1980

aacttcagtt ctgccaagtt tgcttcttcc atcacacagt attccacggg acaggtcagc     2040

gtggagatcg agtgggagct gcagaaggag aacagcaaac gctggaatcc cgaaattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtggacac taatggtgtg     2160

tattcagagc ctcgccccat tggcaccaga tacctgactc gtaatctgta a              2211


<210> 4890
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4890
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Arg Pro Gly Leu Arg Lys Pro Val Lys Thr Ala Pro Gly Lys Lys 
    130                 135                 140                 


Arg Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr 
145                 150                 155                 160 


Gly Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Asp Asp Arg Val 
225                 230                 235                 240 


Ile Ala Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Cys Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Ser Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Pro Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Cys Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys 
        435                 440                 445             


Thr Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Cys Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr 
            580                 585                 590         


Thr Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Ser Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Ser Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 4891
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4891
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagagga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcaaaaaaga gggttctgga acctctgggc ctggttgagg agcctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcagagccag attcctcctc cggaactgga      480

aagtcgggca accagcctgc aagaaagaga ttgaatttcg gtcagactgg agactcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accatctgta caagcaaata      780

tccagccagt ctggagccag caacgacaat cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctagagta ctttccttct     1200

cagatgctgc gtaccggaaa cagctttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtccaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gtcagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa agacgatgaa gaaaagttct ttcctcagag cggggttctt     1620

atctttggga agcaaggctc agagaaaaca aatgtggata ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca agacagagac gtgtacctgc aggggcctat ttgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt tggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatt acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga gatccagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4892
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4892
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Ser Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4893
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 4893
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaagcacag gcgcagaccg gctgggttca aaaccaagga     1800

atacttccgg gtatggtttg gcaggacaga gatgtgtacc tgcaaggacc catttgggcc     1860

aaaattcctc acacggacgg caactttcac ccttctccgc tgatgggagg gtttggaatg     1920

aagcacccgc ctcctcagat cctcatcaaa aacacacctg tacctgcgga tcctccaacg     1980

gccttcaaca aggacaagct gaactctttc atcacccagt attctactgg ccaagtcagc     2040

gtggagatcg agtgggagct gcagaaggaa aacagcaagc gctggaaccc ggagatccag     2100

tacacttcca actattacaa gtctaataat gttgaatttg ctgttaatac tgaaggtgta     2160

tatagtgaac cccgccccat tggcaccaga tacctgactc gtaatctgta a              2211


<210> 4894
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4894
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ser Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Gly Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Ser Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 4895
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 4895
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtt cacagcccgc taaaaagaaa ctcaatttcg gtcagactgg cgacacagag      540

tcagtccccg accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atgggagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gcgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaagcacag gcgcagaccg gctgggttca aaaccaagga     1800

atacttccgg gtatggtttg gcaggacaga gatgtgtacc tgcaaggacc catttgggcc     1860

aaaattcctc acacggacgg caactttcac ccttctccgc taatgggagg gtttggaatg     1920

aagcacccgc ctcctcagat cctcatcaaa aacacacctg tacctgcgga tcctccaacg     1980

gctttcaata aggacaagct gaactctttc atcacccagt attctactgg ccaagtcagc     2040

gtggagattg agtgggagct gcagaaggaa aacagcaagc gctggaaccc ggagatccag     2100

tacacttcca actattacaa gtctaataat gttgaatttg ctgttaatac tgaaggtgta     2160

tatagtgaac cccgccccat tggcaccaga tacctgactc gtaatctgta a              2211


<210> 4896
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4896
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ser Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 4897
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4897
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagcggtgga agctcaaacc tggcccacca ccaccagagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggtacttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cggcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg ggccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4898
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4898
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Arg Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Glu Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Gly Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Gly Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4899
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4899
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagcggtgga agctcaaacc tggcccacca ccaccagagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtccttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggtacttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacgaga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg ggccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4900
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4900
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Arg Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Glu Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Glu Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Gly Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4901
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4901
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagcggtgga agctcaaacc tggcccacca ccaccagagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggtacttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtaccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg ggccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4902
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4902
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Arg Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Glu Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Gly Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4903
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4903
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagcggtgga agctcaaacc tggcccacca ccaccagagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggtactcga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagc aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg ggccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc cgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4904
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4904
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Arg Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Glu Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Ala Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Gly Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4905
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4905
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4906
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 4906
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgttcggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccccg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210> 4907
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4907
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Cys His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4908
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4908
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Arg 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Leu Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Ala Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Pro Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Arg Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Thr Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Ala Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Ala Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4909
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 4909
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcggac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtt      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt atcttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcgcc     1020

agcaccatcc aggtgtttac ggactcggaa taccagccgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctcg ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ctgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatcg cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgcgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 4910
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4910
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcagagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg agcctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttaaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acatacaaca accacctcta caagcaaatc      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcgtc      900

aacaacaacc ggggattccg gcccaaaaga ctcaacttca agctctttaa tattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tgggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cttttgaaga cgtgcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc aaccaacatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaaa caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cagctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa ggatgacgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt catgattaca     1680

gatgaagaag aaatcagggc caccaatccc gtggctacgg agcagtacgg gactgtgtca     1740

aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4911
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4911
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Val Asn Asn Asn Arg 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Ala Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4912
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4912
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Ser Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Ser Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4913
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 4913
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgagct ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattctgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210> 4914
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4914
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Pro Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Pro Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Val Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4915
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 4915
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tacaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ccggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgccacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccgtcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgttg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210> 4916
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4916
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Ser Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Leu 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4917
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 4917
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aagcaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggactt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210> 4918
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 4918
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Pro Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Pro Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Leu His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Val Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe 
    450                 455                 460                 


Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu 
            500                 505                 510         


Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe 
    530                 535                 540                 


Gly Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro 
            580                 585                 590         


Ala Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Ala Lys Ser Ala Ser Val Asp Phe Thr Val Asp Asn Asn Gly 
705                 710                 715                 720 


Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210> 4919
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 4919
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Pro Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Leu His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe 
    450                 455                 460                 


Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu 
            500                 505                 510         


Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe 
    530                 535                 540                 


Gly Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro 
            580                 585                 590         


Ala Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Ala Lys Ser Ala Ser Val Asp Phe Thr Val Asp Asn Asn Gly 
705                 710                 715                 720 


Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210> 4920
<211> 2214
<212> DNA
<213> Adeno-associated virus

<400> 4920
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ccgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgcctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgcac ctgggccttg cccacctaca ataaccacct ctacaagcaa      780

atctccagtg cttcaacggg ggccagcaac gacaaccact acttcggcta cagcaccccc      840

tgggggtatt ttgatttcaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaattgggg attccggccc aagagactca acttcaaact cttcaacatc      960

caagtcaagg aggtcacgac gaatgatggc gtcacaacca tcgctaataa ccttaccagc     1020

acggttcaag tcttctcgga ctcggagtac cagcttccgt acgtcctcgg ctctgcgcac     1080

cagggctgcc tccctccgtt cccggcggac gtgttcatga ttccgcaata cggctacctg     1140

acgctcaaca atggcagcca agccgtggga cgttcatcct tttactgcct ggaatatttc     1200

ccttctcaga tgctgagaac gggcaacaac tttaccttca gctacacctt tgaggaagtg     1260

cctctccaca gcagctacgc gcacagccag agcctggacc ggctgatgaa tcctctcatc     1320

gtccaatacc tgtattacct gaacagaact caaaatcagt ccggaagtgc ccaaaacaag     1380

gacttgctgt tcagccgtgg gtctccagct ggcatgtctg ttcagcccaa aaactggcta     1440

cctggaccct gttatcggca gcagcgcgtt tctaaaacaa aaacagacaa caacaacagc     1500

aattttacct ggactggtgc ttcaaaatat aacctcaatg ggcgtgaatc catcatcaac     1560

cctggcactg ctatggcctc acacaaagac gacgaagaca agttctttcc catgagcggt     1620

gtcatgattt ttggaaaaga gagcgccgga gcttcaaaca ctgcattgga caatgtcatg     1680

attacagacg aagaggaaat taaagccact aaccctgtgg ccaccgaaag atttgggacc     1740

gtggcagtca atttccagag cagcagcaca gaccctgcga ccggagatgt gcatgctatg     1800

ggagcattac ctggcatggt gtggcaagat agagacgtgt acctgcaggg tcccatttgg     1860

gccaaaattc ctcacacaga tggacacttt cacccgtctc ctcttatggg cggctttgga     1920

ctcaagaacc cgcctcctca gatcctcatc aaaaacacgc ctgttcctgc gaatcctccg     1980

gcggagtttt cagctacaaa gtttgcttca ttcatcaccc aatactccac aggacaagtg     2040

agtgtggaaa ttgaatggga gctgcagaaa gaaaacagca agcgctggaa tcccgaagtg     2100

cagtacacat ccaattatgc aaaatctgcc agcgttgatt ttactgtgga caacaatgga     2160

ctttatactg agcctcgccc cattggcacc cgttacctta cccgtcccct gtaa           2214


<210> 4921
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4921
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Arg Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Glu Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Gly Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Pro Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Gly Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4922
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 4922
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcagacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctga gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagggccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg atccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacccgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaaggtaga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 4923
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4923
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Arg Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Gly Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Pro Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Gly Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4924
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4924
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Arg Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Gly Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Gly Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4925
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4925
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Arg Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Gly Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4926
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4926
atggctgccg atggctatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcatagggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcggg gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata ccccaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcac aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccgtgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4927
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4927
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Gly Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Pro Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Thr Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Val Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4928
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 4928
atggctgccg acggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcgggcgggc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actccccctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg atccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcactgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggccgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctctt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ctccacagca gctgcgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacagggac     1380

ttgctgttca gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccgcagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 4929
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4929
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Pro Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Arg Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Ser Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Leu His Ser Ser Cys Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Arg Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Ala Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4930
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4930
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Leu His Ser Ser Cys Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Arg Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4931
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4931
atggctgccg atggctatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcatagggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgggg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacagt cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcac aacaaacact ccaagtggaa ccaccacgca gtcaaggctc     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacaatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4932
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4932
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Gly Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Ser His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Thr Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asn Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4933
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 4933
Arg Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu 
1               5                   10                  15      


Ser Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys 
            20                  25                  30          


Pro Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu 
        35                  40                  45              


Pro Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu 
    50                  55                  60                  


Pro Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr 
65                  70                  75                  80  


Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His 
                85                  90                  95      


Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly 
            100                 105                 110         


Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu 
        115                 120                 125             


Pro Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys 
    130                 135                 140                 


Arg Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Thr Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Gly Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Glu Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe 
    450                 455                 460                 


Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu 
            500                 505                 510         


Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Val Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe 
    530                 535                 540                 


Gly Lys Glu Ser Ala Gly Ala Ser Ser Thr Ala Leu Asp Asn Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro 
            580                 585                 590         


Ala Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly 
705                 710                 715                 720 


Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210> 4934
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4934
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Thr Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Gly Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Glu Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Val Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Ser Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4935
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 4935
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gccagactgg cgactcagag      540

tcagtccccg atccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtactt caacgggggc cagcaacgac aaccactact tcggctacgg caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcgaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaacacaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcaccgctg tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaagcactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 4936
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 4936
Arg Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu 
1               5                   10                  15      


Ser Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys 
            20                  25                  30          


Pro Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu 
        35                  40                  45              


Pro Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu 
    50                  55                  60                  


Pro Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr 
65                  70                  75                  80  


Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His 
                85                  90                  95      


Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly 
            100                 105                 110         


Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu 
        115                 120                 125             


Pro Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys 
    130                 135                 140                 


Arg Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Thr Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Glu Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe 
    450                 455                 460                 


Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu 
            500                 505                 510         


Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Val Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe 
    530                 535                 540                 


Gly Lys Glu Ser Ala Gly Ala Ser Ser Thr Ala Leu Asp Asn Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro 
            580                 585                 590         


Ala Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly 
705                 710                 715                 720 


Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210> 4937
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 4937
Arg Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu 
1               5                   10                  15      


Ser Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys 
            20                  25                  30          


Pro Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu 
        35                  40                  45              


Pro Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu 
    50                  55                  60                  


Pro Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr 
65                  70                  75                  80  


Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His 
                85                  90                  95      


Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly 
            100                 105                 110         


Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu 
        115                 120                 125             


Pro Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys 
    130                 135                 140                 


Arg Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Thr Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe 
    450                 455                 460                 


Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu 
            500                 505                 510         


Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Val Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe 
    530                 535                 540                 


Gly Lys Glu Ser Ala Gly Ala Ser Ser Thr Ala Leu Asp Asn Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro 
            580                 585                 590         


Ala Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly 
705                 710                 715                 720 


Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210> 4938
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 4938
Arg Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu 
1               5                   10                  15      


Ser Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys 
            20                  25                  30          


Pro Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu 
        35                  40                  45              


Pro Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu 
    50                  55                  60                  


Pro Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr 
65                  70                  75                  80  


Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His 
                85                  90                  95      


Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly 
            100                 105                 110         


Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu 
        115                 120                 125             


Pro Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys 
    130                 135                 140                 


Arg Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Thr Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe 
    450                 455                 460                 


Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu 
            500                 505                 510         


Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Val Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe 
    530                 535                 540                 


Gly Lys Glu Ser Ala Gly Ala Asn Ser Thr Ala Leu Asp Asn Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro 
            580                 585                 590         


Ala Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly 
705                 710                 715                 720 


Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210> 4939
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4939
atggctgccg atggttatct tccagattgg ctcaaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcgggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agtacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaacagga      480

aaagcgggcc agcagcctgc gagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaag ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggctctgccc acctacaaca accatctgta caagcagatc      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaggaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc ccggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgagga tgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcaaag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcagaac caccaatccc gtggccacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctactgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgcacctgc aggggcctat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt tggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcaaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtatt ccacagggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaaccccga gatccagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4940
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4940
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Lys Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Gly Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu Tyr Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Ser Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Pro Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val His Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4941
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4941
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcagagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttaaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acatacaaca accacctcta caagcaaatc      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaaaaga ctcaacttca agctctttaa tattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tgggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cttttgaaga cgtgcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc aaccaacatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaaa caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cagctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcgcaa ggatgacgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt catgattaca     1680

gatgaagaag aaatcagggc caccaatccc gtggctacgg agcagtacgg gactgtgtca     1740

aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4942
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4942
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser Arg Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Ala Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4943
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4943
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgggg aacctgtcaa gacggctcca      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcggct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcac aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacaatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtacgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4944
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4944
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Gly Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Gly Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Thr Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asn Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4945
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4945
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgggg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa tcggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta cagacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

agcaacggga gtcaggcagt aggacgctct tcattttact gcccggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcac aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacaatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacctaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atttgtaa                  2208


<210> 4946
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4946
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Gly Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Arg His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Arg Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Ser Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Pro Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Thr Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asn Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Pro Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4947
<211> 2205
<212> DNA
<213> Adeno-associated virus

<400> 4947
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ctgaatttcg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcagacag ccaccagcag cccccacaag tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accaccttta caagcaaatc      780

tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cttttgaaga cgtgcctttc     1260

cacagcagct acgctcacag ccagagtttg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctaaacag aacacaaaca gctagtggaa ctcagcagtc tcggctactg     1380

tttagccaag ctggacccac aagcatgtct cttcaagcta aaaactggct gcctggaccg     1440

tgttatcgcc agcagcgttt gtcaaagcag gcaaacgaca acaacaacag caactttccc     1500

tggactggag ctaccaagta ctacctcaat ggcagagact ctttggtgaa cccgggcccg     1560

gccatggcca gccacaagga cgatgaagaa aagtttttcc ccatgcatgg aaccctaata     1620

tttggtaaag aaggaacaaa tgctaccaac gcggaattgg aaaatgtcat gattacagat     1680

gaagaggaaa tcaggaccac caatcccgtg gctacagagc agtacggata tgtgtcaaat     1740

aatttgcaaa actcaaatac tgctgcaagt actgaaactg tgaatcacca aggagcatta     1800

cctggtatgg tgtggcagga tcgagacgtg tacctgcagg gacccatttg ggccaagatt     1860

cctcacaccg atggacactt tcatccttct ccactgatgg gaggttttgg actcaaacac     1920

ccgcctcctc agattatgat caaaaacact cccgttccag ccaatcctcc cacaaacttc     1980

agttctgcca agtttgcttc cttcatcaca cagtattcca cgggacaggt cagcgtggag     2040

atcgagtggg agctgcagaa ggagaacagc aaacgctgga atcccgaaat tcagtacact     2100

tccaactaca acaaatctgt taatgtggac tttactgtgg acactaatgg tgtgtattca     2160

gagcctcgcc ccattggcac cagatacctg actcgtaatc tgtaa                     2205


<210> 4948
<211> 734
<212> PRT
<213> Adeno-associated virus

<400> 4948
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Arg Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Thr Ala Ser Gly Thr Gln Gln Ser Arg Leu Leu Phe Ser Gln Ala 
    450                 455                 460                 


Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly Pro 
465                 470                 475                 480 


Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn Asn 
                485                 490                 495     


Ser Asn Phe Pro Trp Thr Gly Ala Thr Lys Tyr Tyr Leu Asn Gly Arg 
            500                 505                 510         


Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp Asp 
        515                 520                 525             


Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys Glu 
    530                 535                 540                 


Gly Thr Asn Ala Thr Asn Ala Glu Leu Glu Asn Val Met Ile Thr Asp 
545                 550                 555                 560 


Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly 
                565                 570                 575     


Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Ala Ala Ser Thr Glu 
            580                 585                 590         


Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn 
    690                 695                 700                 


Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210> 4949
<211> 3160
<212> DNA
<213> Adeno-associated virus

<400> 4949
acccttcact aaagggacta gtcctgcagg tttaaacgaa ttcgcccttg ctgcgtcaac       60

tggaccaatg agaactttcc cttcaacgac tgtgtcgaca agatggtgat ttggtgggag      120

gaggggaaga tgaccgccaa ggtcgtggag tcggccaaag ccattctcgg aggaagcaag      180

gtgcgcgtgg accagaaatg caagtcctcg gcccagatag atccgactcc cgtgatcgtc      240

acctccaaca ccaacatgtg cgccgtgatt gacgggaact caacgacctt cgaacaccag      300

cagccgttgc aagaccggat gttcaaattt gaactcaccc gccgtctgga tcatgacttt      360

gggaaggtca ccaagcggga agtcaaagac tttttccggt gggcaaagga tcacgtggtt      420

gaggtggagc atgaattcta cgtcaaaaag ggtggagcca agaaaagacc cgcccctagt      480

gacgcagata taagtgagcc caaacgggtg cgcgagtcag ttgcgcagcc atcgacgtca      540

gacgcggaag cttcgatcaa ctacgcggac aggtaccaaa acaaatgttc tcgtcacgtg      600

ggcatgaatc tgatgctgtt tccctgcaga caatgcgaga gaatgaatca aaattcaaat      660

atctgcttca ctcacggaca gaaagactgt ttagagtgct ttcccgtgtc agaatctcaa      720

cctgtttctg tcgtcaaaaa ggcgtatcag aaactgtgct acattcatca tatcatggga      780

aaggtgccag acgcttgcac tgcctgcgat ctggtcaatg tggatttgga tgactgcatc      840

tctgaacaat aaatgattta aatcaggtat ggctgccgat ggttatcttc cagattggct      900

cgaggacact ctctctgaag gaataagaca gtggtggaag ctcaaacctg gcccaccacc      960

accaaagccc gcagagcggc ataaggacga cagcaggggt cttgtgcttc ctgggtacaa     1020

gtacctcgga cccttcaacg gactcgacaa gggagagccg gtcaacgagg cagacgccgc     1080

ggccctcgag cacgacaagg cctacgaccg gcagctcgac agcggagaca acccgtacct     1140

caagtacaac cacgccgacg cggagtttca ggagcgtctt aaagaagata cgtcttttgg     1200

gggcaacctc ggacgagcag tcttccaggc gaaaaagagg gttcttgaac ctctgggcct     1260

ggttgaggaa cctgttaaga cggctccggg aaaaaagagg ccggtagagc actctcctgc     1320

ggagccagac tcctcctcgg gaaccggaaa agcgggccag cagcctgcaa gaaaaagact     1380

gaatttcggt cagactggag acgcagactc cgtacctgac ccccagcctc tcagacagcc     1440

accagcagcc cccacaagtt tgggatctac tacaatggct acaggcagtg gcgcaccaat     1500

ggcagacaat aacgagggtg ccgatggagt gggtaattcc tcaggaaatt ggcattgcga     1560

ttcccaatgg ctgggcgaca gagtcatcac caccagcacc cgaacctggg ccctgcccac     1620

ctacaacaac cacctttaca agcaaatctc cagccaatca ggagcctcaa acgacaacca     1680

ctactttggc tacagcaccc cctgggggta ttttgacttc aacagattcc actgccactt     1740

ttcaccacgt gactggcaaa gactcatcaa caacaactgg ggattccgac ccaagagact     1800

caacttcaag ctctttaaca ttcaagtcaa agaggtcacg cagaatgacg gtacgacgac     1860

gattgccaat aaccttacca gcacggttca ggtgtttact gactcggagt accagctccc     1920

gtacgtcctc ggctcggcgc atcaaggatg cctcccgccg tttccagcgg acgtcttcat     1980

ggtcccacag tatggatacc tcaccctgaa caacgggagt caggcggtag gacgctcttc     2040

cttttactgc ctggagtact ttccttctca gatgctgcgt actggaaaca actttcagtt     2100

cagctacact tttgaagacg tgcctttcca cagcagctac gctcacagcc agagtttgga     2160

tcggctgatg aatcctctga tcgaccagta cctgtattat ctaaacagaa cacaaacagc     2220

tagtggaact cagcagtctc ggctactgtt tagccaagct ggacccacaa gcatgtctct     2280

tcaagctaaa aactggctgc ctggaccgtg ttatcgccag cagcgtttgt caaagcaggc     2340

aaacgacaac aacaacagca actttccctg gactggagct accaagtact acctcaatgg     2400

cagagactct ttggtgaacc cgggcccggc catggccagc cacaaggacg atgaagaaaa     2460

gtttttcccc atgcatggaa ccctaatatt tggtaaagaa ggaacaaatg ctaccaacgc     2520

ggaattggaa aatgtcatga ttacagatga agaggaaatc aggaccacca atcccgtggc     2580

tacagagcag tacggatatg tgtcaaataa tttgcaaaac tcaaatactg ctgcaagtac     2640

tgaaactgtg aatcaccaag gagcattacc tggtatggtg tggcaggatc gagacgtgta     2700

cctgcaggga cccatttggg ccaagattcc tcacaccgat ggacactttc atccttctcc     2760

actgatggga ggttttggac tcaaacaccc gcctcctcag attatgatca aaaacactcc     2820

cgttccagcc aatcctccca caaacttcag ttctgccaag tttgcttcct tcatcacaca     2880

gtattccacg ggacaggtca gcgtggagat cgagtgggag ctgcagaagg agaacagcaa     2940

acgctggaat cccgaaattc agtacacttc caactacaac aaatctgtta atgtggactt     3000

tactgtggac actaatggtg tgtattcaga gcctcgcccc attggcacca gatacctgac     3060

tcgtaatctg taattgcttg ttaatcaata aaccgtttaa ttcgtttcag ttgaactttg     3120

gtctctgcga agggcgaatt cgcggccgct aaatcaatcg                           3160


<210> 4950
<211> 734
<212> PRT
<213> Adeno-associated virus

<400> 4950
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys Arg Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Gly Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Thr Ala Ser Gly Thr Gln Gln Ser Arg Leu Leu Phe Ser Gln Ala 
    450                 455                 460                 


Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly Pro 
465                 470                 475                 480 


Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn Asn 
                485                 490                 495     


Ser Asn Phe Pro Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Gly 
            500                 505                 510         


Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp Asp 
        515                 520                 525             


Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys Glu 
    530                 535                 540                 


Gly Thr Asn Ala Thr Asn Ala Glu Leu Glu Asn Val Met Ile Thr Asp 
545                 550                 555                 560 


Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly 
                565                 570                 575     


Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Ala Ala Ser Thr Glu 
            580                 585                 590         


Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Arg Gly Pro Ile Trp Ala Lys Ile Pro His Ala Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn 
    690                 695                 700                 


Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210> 4951
<211> 3157
<212> DNA
<213> Adeno-associated virus

<400> 4951
ctcactaagg gactagtcct gcaggtttaa acgaattcgc ccttgctgcg tcaactggac       60

caatgagaac tttcccttca acgactgtgt cgacaagatg gtgatttggt gggaggaggg      120

gaagatgacc gccaaggtcg tggagtcggc caaagccact ctcggaggaa gcaaggtgcg      180

cgtggaccag aaacgcaagt cctcggccca gatagatccg actcccgtga tcgtcacctc      240

caacaccaac atgtgcgccg tgattgacgg gaactcaacg accttcgaac accagcagcc      300

gttgcaagac cgaatgttca aatttgaact cacccgccgt ctggatcatg acttcgggaa      360

ggtcaccaag caggaagtca aagacttttt ccggtgggca aaggatcacg tggttgaggt      420

ggagcatgaa ttctacgtca aaaagggtgg agccaagaaa agacccgccc ctagtgacgc      480

agatataagt gagcccaaac gggtgcgcga gtcagttgcg cagccatcga cgtcagacgc      540

ggaagcttcg atcaactacg cggacaggta ccaaaacaaa tgttctcgtc acgtgggcat      600

gaatctgatg ctgtttccct gcagacaatg cgagagaatg aatcaaaatt caaatatctg      660

cttcactcac ggacagaaag actgtttaga gtgctttccc gtgtcagaat ctcaacctgt      720

ttctgtcgtc aaaaaggcgt atcagaaact gtgctacatt catcatatca tgggaaaggt      780

gccagacgct tgcactgcct gcgatctggt caatgtggat ttggatgact gcatctctga      840

acaataaatg atttaaatca ggtatggctg ccgatggtta tcttccagat tggctcgagg      900

acactctctc tgaaggaata agacagtggt ggaagctcaa acctggccca ccaccaccaa      960

agcccgcaga gcggcataag gacgacagca ggggtcttgt gcttcctggg tacaagtacc     1020

tcggaccctt caacggactc gacaagggag agccggtcaa cgaggcagac gccgcggctc     1080

tcgagcacga caaggcctac gaccggcagc tcgacagcgg agacaacccg tacctcaagt     1140

acaaccacgc cgacgcggag tttcaggagc gtcttaaaga agatacgtct tttgggggca     1200

acctcggacg agcagtcttc caggcgaaaa agagggttct tgaacctctg ggcctggttg     1260

aggaacctgt taagacggct ccgggaaaaa agaggccggt agagcactct cctgcggagc     1320

cagactcctc ctcgggaacc ggaaaagcgg gccagcagcc tgcaagaaaa agactgaatt     1380

tcggtcagac tggagacgca gactccgtac ctgaccccca gcctctcgga cagccaccag     1440

cagcccccac aagtttggga tctactacaa tggctacagg cagtggcgca ccaatggcag     1500

acaataacga gggtgccgat ggagtgggta attcctcagg aaattggcat tgcgattccc     1560

aatggctggg cgacagagtc atcaccacca gcacccgaac ctgggccctg cccacctaca     1620

acaaccacct ttacaagcaa atctccagcc aatcaggagc ctcaaacgac aaccactact     1680

ttggctacag caccccctgg gggtattttg acttcaacag attccactgc cgcttttcac     1740

cacgtgactg gcaaagactc atcaacaaca actggggatt ccgacccaag agactcaact     1800

tcaagctctt taacattcaa gtcaaagagg tcacgcagaa tgacggtacg acgacgattg     1860

ccaataacct taccagcacg gttcaggtgt ttactgactc ggagtaccag ctcccgtacg     1920

tcctcggctc ggcgcatcaa ggatgcctcc cgccgtttcc agcggacgtc ttcatggtcc     1980

cacagtatgg atacctcacc ctgaacaacg ggagtcaggc ggtaggacgc tcttcctttt     2040

actgcctgga gtactttcct tctcagatgc tgcgtactgg aaacaacttt cagttcagct     2100

acacttttga agacgtgcct ttccacagca gctacgctca cagccagggt ttggatcggc     2160

tgatgaatcc tctgatcgac cagtacctgt attatctaaa cagaacacaa acagctagtg     2220

gaactcagca gtctcggcta ctgtttagcc aagctggacc cacaagcatg tctcttcaag     2280

ctaaaaactg gctgcctgga ccgtgttatc gccagcagcg tttgtcaaag caggcaaacg     2340

acaacaacaa cagcaacttt ccctggactg gagctaccaa gtaccacctc aatggcggag     2400

actctttggt gaacccgggc ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt     2460

tccccatgca tggaacccta atatttggta aagaaggaac aaatgctacc aacgcggaat     2520

tggaaaatgt catgattaca gatgaagagg aaatcaggac caccaatccc gtggctacag     2580

agcagtacgg atatgtgtca aataatttgc aaaactcaaa tactgctgca agtactgaaa     2640

ctgtgaatca ccaaggagca ttacctggta tggtgtggca ggatcgagac gtgtacctgc     2700

ggggacccat ttgggccaag attcctcacg ccgatggaca ctttcatcct tctccactga     2760

tgggaggttt tggactcaaa cacccgcctc ctcagattat gatcaaaaac actcccgttc     2820

cagccaatcc tcccacaaac ttcagttctg ccaagtttgc ttccttcatc acacagtatt     2880

ccacgggaca ggtcagcgtg gagatcgagt gggagctgca gaaggagaac agcaaacgct     2940

ggaatcccga aattcagtac acttccaact acaacaaatc tgttaatgtg gactttactg     3000

tggacactaa tggtgtgtat tcagagcctc gccccattgg caccagatac ctgactcgta     3060

atctgtaatt gcttgttaat caataaaccg tttaattcgt ttcagttgaa ctttggtctc     3120

tgcgaagggc gaattcgcgg ccgctaaatt caattcg                              3157


<210> 4952
<211> 734
<212> PRT
<213> Adeno-associated virus

<400> 4952
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Cys Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Thr Ala Ser Gly Thr Gln Gln Ser Arg Leu Leu Phe Ser Gln Ala 
    450                 455                 460                 


Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly Pro 
465                 470                 475                 480 


Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn Asn 
                485                 490                 495     


Ser Asn Phe Pro Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg 
            500                 505                 510         


Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp Asp 
        515                 520                 525             


Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys Glu 
    530                 535                 540                 


Gly Thr Asn Ala Thr Asn Ala Glu Leu Glu Asn Val Met Ile Thr Asp 
545                 550                 555                 560 


Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly 
                565                 570                 575     


Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Ala Ala Ser Thr Glu 
            580                 585                 590         


Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn 
    690                 695                 700                 


Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210> 4953
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4953
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctggatac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggca accagcctgc aagaaaaaga ttgaatttcg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcat ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcgtc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accacctcta caagcagatt      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcgccac gcgactggca gagactcatc      900

aacaacaact ggggattccg gcccaaaaga ctcaacttca agctgtttaa cattcaagtc      960

aaggaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgacttgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gcaccggaaa caactttacc ttcagctaca cttttgaaga cgttcctttc     1260

cacagcagct acgctcacag tcaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccactacgca gtccaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcaaag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaaa     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt tggacttaaa     1920

caccctcctc cacagattct cattaagaat accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagcgcgg caaagtttgc ttccttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggggtgtat     2160

tcagagcctc gccctattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4954
<211> 3159
<212> DNA
<213> Adeno-associated virus

<400> 4954
gattgattta gcggccgcga attcgccctt gctgcgtcaa ctggaccaat gagaactttc       60

ccttcaacga ttgcgtcgac aagatggtga tctggtggga ggagggaaag atgaccgcca      120

aggtcgtgga gtcggccaaa gccattctcg gaggaagcaa ggtgcgtgtg gaccaaaagt      180

gcaagtcttc ggcccagatc gacccgactc ccgtgatcgt cacctccaac accaacatgt      240

gcgccgtgat tgatggaaac tcaacgacct tcgagcacca gcagccgttg caagaccgga      300

tgttcaaatt tgaacttacc cgccgtctgg atcatgactt tggaaaggtc accaagcagg      360

aagtgaaaga ctttttccgg tgggcaaagg atcacgtggt tgaggtggag catgagttct      420

acgtcaaaaa gggtggagcc aaaaaaagac ccgcccccag tgacgcagat ataagtgagc      480

ccaaacgggc gcgcgagtca gttgcgcagc catcgacgtc agacgcggaa gcttcgatca      540

actacgcgga caggtaccaa aacaaatgtt ctcgtcacgt gggcatgaat ctgatgctgt      600

ttccctgcag acaatgcgag agaatgaatc agaattcaaa tatctgcttc actcacggac      660

agaaagactg tccatagtgc tttcccgtgt cagaatctca acccgtttct gtcgtcaaaa      720

aggcgtatca gaaactgtgc tacattcatc acatcatggg aaaggtgcca gacgcttgca      780

ctgcttgcga cctggtcaat gtggatttgg atgactgcat ctctgaacaa taaatgattt      840

aaatcaggta tggctgccga tggttatctt ccagattggc tcgaggacac tctctctgaa      900

ggaataagac agtggtggaa gctcaaacct ggcccaccac caccaaagcc cgcagagcgg      960

cataaggacg acagcagggg tcttgtgctt cctggataca agtacctcgg acccttcaac     1020

ggactcgaca agggagagcc ggtcaacgag gcagacgccg cggccctcga gcacgacaag     1080

gcctacgacc ggcagctcga cagcggagac aacccgtacc tcaagtacaa ccacgccgac     1140

gcggagtttc aggagcgcct taaagaagat acgtcttttg ggggcaacct cggacgagca     1200

gtcttccagg cgaaaaagag ggttcttgaa cctctgggcc tggttgagga acctgttaag     1260

acggctccgg gaaaaaagag gccggtagag cactctcctg tggagccaga ctcctcctcg     1320

ggaaccggaa aagcgggcaa ccagcctgca agaaaaagat tgaatttcgg tcagactgga     1380

gacgcagact ccgtacctga cccccagcct ctcggacagc caccagcatc cccctctggt     1440

ctgggaacta atacgatggc tacaggcagt ggcgcaccaa tggcagacaa taacgagggc     1500

gccgacggag tgggtaattc ctcgggaaat tggcattgcg attccacatg gatgggcgac     1560

agagtcgtca ccaccagcac ccgcacctgg gccctgccca cctacaacaa ccacctctac     1620

aagcagattt ccagccaatc aggagccagc aacgacaacc actactttgg ctacagcacc     1680

ccttgggggt attttgactt caacagattc cactgccact tttcgccacg cgactggcag     1740

agactcatca acaacaactg gggattccgg cccaaaagac tcaacttcaa gctgtttaac     1800

attcaagtca aggaggtcac gcagaatgac ggtacgacga cgattgccaa taaccttacc     1860

agcacggttc aggtgtttac tgacttggag taccagctcc cgtacgtcct cggctcggcg     1920

catcaaggat gcctcccgcc gttcccagca gacgtcttca tggtgccaca gtatggatac     1980

ctcaccctga acaacgggag tcaggcggta ggacgctctt ccttttactg cctggagtac     2040

tttccttctc agatgcttcg caccggaaac aactttacct tcagctacac ttttgaagac     2100

gttcctttcc acagcagcta cgctcacagt caaagtctgg accgtctcat gaatcctctc     2160

atcgaccagt acctgtatta cttgagcaga acaaacactc caagcggaac cactacgcag     2220

tccaggcttc agttttctca ggccggagcg agtgacattc gggaccagtc taggaactgg     2280

cttcctggac cctgttaccg ccagcagcga gtatcaaaga cagctgcgga taacaacaac     2340

agtgaatact cgtggactgg agctaccaag taccacctca atggcagaga ctctctggtg     2400

aatccgggcc cggccatggc cagccacaag gacgatgaag aaaagttttt tcctcaaagc     2460

ggggttctca tctttgggaa gcaaggctca gagaaaacaa atgtggacat tgaaaaggtc     2520

atgattacag acgaagagga aatcaggacc accaatcccg tggctacgga gcagtatggt     2580

tctgtatcta ccaacctcca gagcggcaac acacaagcag ctacctcaga tgtcaacaca     2640

caaggcgttc ttccaggcat ggtctggcag gacagagacg tgtacctgca ggggcccatc     2700

tgggcaaaaa ttccacacac ggacggacat tttcacccct ctcccctcat gggcggattt     2760

ggacttaaac accctcctcc acagattctc attaagaata ccccggtacc tgcgaatcct     2820

tcgaccacct tcagcgcggc aaagtttgct tccttcatca cacagtattc cacggggcag     2880

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaatcccgaa     2940

attcagtaca cttccaacta caacaaatct gttaatgtgg actttactgt ggacactaat     3000

ggggtgtatt cagagcctcg ccctattggc accagatacc tgactcgtaa tctgtaattg     3060

cttgttaatc aataaaccgt ttaattcgtt tcagttgaac tttggtctct gcgaagggcg     3120

aattcgttta aacctgcagg actagtccct ttagtgagg                            3159


<210> 4955
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4955
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ser Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Val 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Leu Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4956
<211> 2205
<212> DNA
<213> Adeno-associated virus

<400> 4956
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaaagcccg cagagcggca taaggacgac      120

agcaggggtc ttgtgcttcc tggatacaag tacctcggac ccttcaacgg actcgacaag      180

ggagagccgg tcaacgaggc agacgccgcg gccctcgagc acgacaaggc ctacgaccgg      240

cagctcgaca gcggagacaa cccgtacctc aagtacaacc acgccgacgc ggagtttcag      300

gagcgcctta aagaagatac gtcttttggg ggcaacctcg gacgagcagt cttccaggcg      360

aaaaagaggg ttcttgaacc tctgggcctg gttgaggaac ctgttaagac ggctccggga      420

aaaaagaggc ccgtagagca ctctcctgtg gagccagact cctcctcggg aaccggaaaa      480

gcgggcaacc agcctgcaag aaaaagattg aatttcggtc agactggaga cgcagactcc      540

gtacctgacc cccagcctct cggacagcca ccagcagccc cctctggtct gggaactaat      600

acgatggcta caggcagtgg cgcaccaatg gcagacaata acgagggcgc cgacggagtg      660

ggtaattcct cgggagattg gcattgcgat tccacatgga tgggcgacag agtcatcacc      720

accagcaccc gcacctgggc cctgcccacc tacaacaacc acctctacaa gcagatttcc      780

agccaatcag gagccagcaa tgacaaccac tactttggct acagcacccc ttgggggtat      840

tttgacttca acagattcca ctgccacttt tcgccacgcg actggcagag actcatcaac      900

aacaactggg gattccggcc caaaagactc aacctcaagc tgtttaacat tcaagtcaag      960

gaggtcacgc agaatgacgg tacgacgacg attgccaata accttaccag cacggttcag     1020

gtgtttactg acttggagta ccagctcccg tacgtcctcg gctcggcgca tcaaggatgc     1080

ctcccgccgt tcccagcaga cgtcttcatg gtgccacagt atggatacct caccctgaac     1140

aacgggagtc aggcggtagg acgctcttcc ttttactgcc tggagtactt tccttctcag     1200

atgcttcgta ccggaaacaa ctttaccttc agctacactt ttgaagacgt tcctttccac     1260

agcagctacg ctcacagtca aagtctggac cgtctcatga atcctctcat cgaccagtac     1320

ctgtattact tgagcagaac aaacactcca agcggaacca ctacgcagtc caggcttcag     1380

ttttctcagg ccggagcgag tgacattcgg gaccagtcta ggaactggct tcctggaccc     1440

tgttaccgcc agcagcgagt atcaaagaca gctgcggata acaacaacgg tgaatactcg     1500

tggactggag ctaccaagta ccacctcaat ggcagagact ctctggtgaa tccgggcccg     1560

gccatggcca gccacaagga cgatgaagaa aagttttttc ctcaaagcgg ggttctcatc     1620

tttgggaagc aaggctcaga gaaaacaaat gtggacattg aaaaggtcat gattacagac     1680

gaagaggaaa tcaggaccac caatcccgtg gctacggagc agtatggttc tgtatctacc     1740

aacctccaga gcggcaacac acgagcagct acctcagatg tcaacacaca aggcgttctt     1800

ccaggcatgg tctggcagga cagagacgtg tacctgcagg ggcccatctg ggcaaaaatt     1860

ccacacacgg acggacattt tcacccctct cccctcatgg gcggatttgg acttaaacac     1920

cctcctccac agattctcat taagaatacc ccggtacctg cgaatccttc gaccaccttc     1980

agcgcggcaa agtttgcttc cttcatcaca cagtattcca cggggcaggt cagcgtggag     2040

atcgagtggg agctgcagaa ggagaacagc aaacgctgga atcccgaaat tcagtacact     2100

tccaactaca acaaatctgt taatgtggac tttactgtgg acactaatgg ggtgtattca     2160

gagcctcgcc ctattggcac cagatacctg actcgtaatc tgtaa                     2205


<210> 4957
<211> 3156
<212> DNA
<213> Adeno-associated virus

<400> 4957
cgattgaatt tagcggccgc gaattcgccc ttgctgcgtc aacggaccaa tgagaacttt       60

cccttcaacg attgcgtcga caagatggtg atctggtggg aggagggaaa gatgaccgcc      120

aaggtcgtgg agtcggccaa agccattctc ggaggaagca aggtgcgtgt ggaccaaaag      180

tgcaagtctt cggcccagat cgacccgact cccgtgatcg tcacctccaa caccaacatg      240

tgcgccgtga ttgatggaaa ctcaacgacc ttcgagcacc agcagccgtt gcaagaccgg      300

atgttcaaat ttgaacttac ccgccgtctg gatcatgact ttggaaaggt caccaagcag      360

gaagtgaaag actttttccg gtgggcaaag gatcacgtgg ttgaggtgga gcatgagttc      420

tacgtcaaaa agggtggagc caaaaaaaga cccgccccca gtgacgcaga tataagtgag      480

cccaaacggg cgcgcgagtc agttgcgcag ccatcgacgt cagacgcgga agcttcgatc      540

aactacgcgg acaggtacca aaacaaatgt tctcgtcacg tgggcatgaa tctgatgctg      600

tttccctgca gacaatgcga gcgaatgaat cagaattcaa atatctgctt cactcacgga      660

cagaaagact gtttagagtg ctttcccgtg tcagaatctc aacccgtttc tgtcgtcaaa      720

aaggcgtatc agaaactgtg ctacattcat cacatcatgg gaaaggtgcc agacgcttgc      780

actgcttgcg acctggtcaa tgtggatttg gatgactgca tctctgaaca ataaatgatt      840

taaatcaggt atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga      900

aggaataaga cagtggtgga agctcaaacc tggcccacca ccaaagcccg cagagcggca      960

taaggacgac agcaggggtc ttgtgcttcc tggatacaag tacctcggac ccttcaacgg     1020

actcgacaag ggagagccgg tcaacgaggc agacgccgcg gccctcgagc acgacaaggc     1080

ctacgaccgg cagctcgaca gcggagacaa cccgtacctc aagtacaacc acgccgacgc     1140

ggagtttcag gagcgcctta aagaagatac gtcttttggg ggcaacctcg gacgagcagt     1200

cttccaggcg aaaaagaggg ttcttgaacc tctgggcctg gttgaggaac ctgttaagac     1260

ggctccggga aaaaagaggc ccgtagagca ctctcctgtg gagccagact cctcctcggg     1320

aaccggaaaa gcgggcaacc agcctgcaag aaaaagattg aatttcggtc agactggaga     1380

cgcagactcc gtacctgacc cccagcctct cggacagcca ccagcagccc cctctggtct     1440

gggaactaat acgatggcta caggcagtgg cgcaccaatg gcagacaata acgagggcgc     1500

cgacggagtg ggtaattcct cgggagattg gcattgcgat tccacatgga tgggcgacag     1560

agtcatcacc accagcaccc gcacctgggc cctgcccacc tacaacaacc acctctacaa     1620

gcagatttcc agccaatcag gagccagcaa tgacaaccac tactttggct acagcacccc     1680

ttgggggtat tttgacttca acagattcca ctgccacttt tcgccacgcg actggcagag     1740

actcatcaac aacaactggg gattccggcc caaaagactc aacctcaagc tgtttaacat     1800

tcaagtcaag gaggtcacgc agaatgacgg tacgacgacg attgccaata accttaccag     1860

cacggttcag gtgtttactg acttggagta ccagctcccg tacgtcctcg gctcggcgca     1920

tcaaggatgc ctcccgccgt tcccagcaga cgtcttcatg gtgccacagt atggatacct     1980

caccctgaac aacgggagtc aggcggtagg acgctcttcc ttttactgcc tggagtactt     2040

tccttctcag atgcttcgta ccggaaacaa ctttaccttc agctacactt ttgaagacgt     2100

tcctttccac agcagctacg ctcacagtca aagtctggac cgtctcatga atcctctcat     2160

cgaccagtac ctgtattact tgagcagaac aaacactcca agcggaacca ctacgcagtc     2220

caggcttcag ttttctcagg ccggagcgag tgacattcgg gaccagtcta ggaactggct     2280

tcctggaccc tgttaccgcc agcagcgagt atcaaagaca gctgcggata acaacaacgg     2340

tgaatactcg tggactggag ctaccaagta ccacctcaat ggcagagact ctctggtgaa     2400

tccgggcccg gccatggcca gccacaagga cgatgaagaa aagttttttc ctcaaagcgg     2460

ggttctcatc tttgggaagc aaggctcaga gaaaacaaat gtggacattg aaaaggtcat     2520

gattacagac gaagaggaaa tcaggaccac caatcccgtg gctacggagc agtatggttc     2580

tgtatctacc aacctccaga gcggcaacac acgagcagct acctcagatg tcaacacaca     2640

aggcgttctt ccaggcatgg tctggcagga cagagacgtg tacctgcagg ggcccatctg     2700

ggcaaaaatt ccacacacgg acggacattt tcacccctct cccctcatgg gcggatttgg     2760

acttaaacac cctcctccac agattctcat taagaatacc ccggtacctg cgaatccttc     2820

gaccaccttc agcgcggcaa agtttgcttc cttcatcaca cagtattcca cggggcaggt     2880

cagcgtggag atcgagtggg agctgcagaa ggagaacagc aaacgctgga atcccgaaat     2940

tcagtacact tccaactaca acaaatctgt taatgtggac tttactgtgg acactaatgg     3000

ggtgtattca gagcctcgcc ctattggcac cagatacctg actcgtaatc tgtaattgct     3060

tgttaatcaa taaaccgttt aattcgtttc agttgaactt tggtctctgc gaagggcgaa     3120

ttcgtttaaa cctgcaggac tagtcccttt agtgag                               3156


<210> 4958
<211> 734
<212> PRT
<213> Adeno-associated virus

<400> 4958
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Lys 
            20                  25                  30          


Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Arg 
65                  70                  75                  80  


Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly Lys 
145                 150                 155                 160 


Ala Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly Ala 
        195                 200                 205             


Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser Ser 
    210                 215                 220                 


Gly Asp Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr Phe 
            260                 265                 270         


Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys 
        275                 280                 285             


His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly 
    290                 295                 300                 


Phe Arg Pro Lys Arg Leu Asn Leu Lys Leu Phe Asn Ile Gln Val Lys 
305                 310                 315                 320 


Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu Thr 
                325                 330                 335     


Ser Thr Val Gln Val Phe Thr Asp Leu Glu Tyr Gln Leu Pro Tyr Val 
            340                 345                 350         


Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val 
        355                 360                 365             


Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln 
    370                 375                 380                 


Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln 
385                 390                 395                 400 


Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu Asp 
                405                 410                 415     


Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu 
            420                 425                 430         


Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Asn 
        435                 440                 445             


Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln Ala 
    450                 455                 460                 


Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly Pro 
465                 470                 475                 480 


Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn Asn 
                485                 490                 495     


Gly Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg 
            500                 505                 510         


Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp Asp 
        515                 520                 525             


Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys Gln 
    530                 535                 540                 


Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr Asp 
545                 550                 555                 560 


Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly 
                565                 570                 575     


Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Arg Ala Ala Thr Ser 
            580                 585                 590         


Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn 
    690                 695                 700                 


Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210> 4959
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4959
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtacg accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcaaaaaaga gggttcttga acctctgggc ctggttgagg agcctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggca accagcctgc aagaaagaga ttgaatttcg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgatgg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggctctgccc acctacaaca accatctgta caagcagatt      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcaacttca agctctttaa cattcaagtc      960

agagaggtca cgcagaatga tggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta cttcccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga tgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtccaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggatcagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg acaacaacaa cagtgaatac     1500

tcgtggattg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggcaatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggaa aacaaggatc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcagaac caccaatccc gtggccacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca tctactgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcctat ctgggcaaag     1860

attccgcaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacagattct catcaaaaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtatt ccacggggcg ggtcagcgtg     2040

gagatcgagt gggagctaca gaaggagaac agcaaacgct ggaatcccga gatccagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4960
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4960
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asp His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Asp Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Arg Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Ile Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ser Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Arg Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4961
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 4961
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagacag gccagcagcc cgcgaaaaag agactcaact ttgggcagac tggcgactca      540

gagtcagtgc ccgaccctca accaatcgga gaaccccccg caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattccg catggctggg cgacagagtc      720

atcaccacca gcacccgacc ctgggccctc cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcaacttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtctttac ggactcggaa taccagctcc cgtacgtcct cggctctgcg     1080

caccagggct gcccgcctcc gttcccggcg gacgtcttca tgattcctca gtacgggtac     1140

ctgactctga acaacggcag tcaggccgtg ggccgttcct ccttctactg cctggagtac     1200

tttccttctc aaatgcggag aacgggcaac aactttgagt tcagctacca gtttgaggac     1260

gtgccttttc acagcagcta cgcgcatagc caaagcctgg accggctgat gaaccccctc     1320

atcgaccagt acctgtacta cctgtctcgg actcagtcca cgggaggtac cgcaggaact     1380

cagcagttgc tattttctca ggccgggcct aataacatgt cggctcaggc caaaaactgg     1440

ctacccgggc cctgctaccg gcagcaacgc gtctccacga cactgtcgca aaataacaac     1500

agcaactttg cttggaccgg tgccaccaag tatcatctga atggcagaga ctctctggta     1560

aatcccggtg tcgctatggc aacgcacaag gacgacgaag agcgattttt tccatccagc     1620

ggagtcttga tgtttgggaa acagggagct ggaaaagaca acgtggacta tagcagcgtt     1680

atgctaacca gtgaggaaga aatcaaaacc accaacccag tggccacaga acagtacggc     1740

gtggtggccg ataacctgca acagcaaaac gccgctccta ttgtaggggc cgtcaacagt     1800

caaggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatc     1860

tgggccaaga ttcctcacac ggacggcaac tttcatcctt cgccgctgat gggaggcttt     1920

ggactgaaac acccgcctcc tcagatcctg attaagaata cacctgttcc cgcggatcct     1980

ccaactacct tcagtcaagc caagctggcg tcgttcatca cgcagtacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaagagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt caatactgag     2160

ggtacttatt cagagcctcg ccccattggc acccgttacc tcacccgtaa cctgtaa        2217


<210> 4962
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4962
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Ala Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Pro Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Pro Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Arg Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4963
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4963
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Val Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4964
<211> 3158
<212> DNA
<213> Adeno-associated virus

<400> 4964
gattgaattt agcggccgcg aattcgccct tgctgcgtca actggaccaa tgagaacttt       60

cctttcaatg attgcgtcga caagatggtg atctggtggg aggagggaaa gatgaccgcc      120

aaggtcgtgg agtcggccaa agccattctc ggaggaagca aggtgcgcgc ggaccagaaa      180

tgcaagtcct cggcccagat agacccgact cccgtgattg tcacctccaa caccaacatg      240

tgcgccgtga ttgacgggaa ctcaacgacc ttcgaacacc agcagccgtt gcaagaccgg      300

atgttcaaat ttgaactcac ccgccgtctg gatcatgact ttgggaaggt caccaagcag      360

gaagtcaaag actttttccg gtgggcaaag gatcacgtgg ttgaggtgga gcatgaattc      420

tacgtcaaaa agggtggagc taagaaaaga cccgccccca gtgacgcaga tataagtgag      480

cccaaacggg cgcgcgagtc agttgcgcag ccatcgacgt cagacgcgga agcttcgatc      540

aactacgcgg gcaggtacca aaacaaatgt tctcgtcacg tgggcatgaa tctgatgctg      600

tttccctgca gacaatgcga gagaatgaat cagaattcaa atatctgctt cactcacgga      660

cagaaagact gtttagagtg ctttcccgtg tcagaatctc aacccgtttc tgtcgtcaaa      720

aaggcgtatc agaaactttg ctacattcat catatcatgg gaaaggtgcc agacgcttgc      780

actgcctgcg atctggtcaa tgtggatttg gatgactgca tctctgaaca ataaatgatt      840

taaatcaggt atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga      900

aggaataaga cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg      960

gcataaggac gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa     1020

cggactcgac aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa     1080

ggcctacgac cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga     1140

cgcggagttt caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc     1200

agtcttccag gcaaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa     1260

aacggctccg ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc     1320

gggaaccgga aaagcgggcc agcagcctgc aagaaaaaga ttgaatttcg gtcagactgg     1380

agacgcagac tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg     1440

tctgggatct actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg     1500

tgccgatgga gtgggtaatt cctcgggaaa ttggcattgc gattcccaat ggctgggcga     1560

cagagtcatc accaccagca cccgcacctg ggccctgccc acctacaaca accacctcta     1620

caagcaaatc tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac     1680

cccctggggg tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca     1740

aagactcatc aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa     1800

cattcaagtc aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac     1860

cagcacggtt caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc     1920

gcatcaagga tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata     1980

cctcaccctg aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta     2040

ctttccttct cagatgctgc gtaccggaaa caactttcaa ttcagctaca cttttgaaga     2100

cgtgcctttc cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct     2160

ggtcgaccag tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca     2220

gtctcggcta ctgtttagcc aagctggacc caccaacatg tctcttcaag ctaaaaactg     2280

gctgcctgga ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa     2340

cagcaacttt ccctggactg cagctacaaa gtatcatcta aatggccggg actcgttggt     2400

taatccagga ccagctatgg ccagtcacaa ggatgacgaa gaaaagtttt tccccatgca     2460

tggaaccctt atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt     2520

catgattaca gatgaagaag aaatcaggac caccaatccc gtggctacgg agcagtacgg     2580

aactgtatca aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatca     2640

ccaaggagcg ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat     2700

ttgggccaag attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt     2760

tggactcaaa cacccacctc ctcaaatcat gatcaaaaac actcccgttc cagccaatcc     2820

tcccacaaac ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacggggca     2880

ggtcagcgtg gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga     2940

aattcagtac acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa     3000

tggtgtgtat tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaatt     3060

gcttgttaat caataaaccg tttaattcgt ttcagttgaa ctttggtctc tgcgaagggc     3120

gaattcgttt aaacctgcag gactagtccc tttagtga                             3158


<210> 4965
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4965
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Pro Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Arg Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Val Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4966
<211> 3159
<212> DNA
<213> Adeno-associated virus

<400> 4966
gattgaattt agcggccgcg aattcgccct tgctgcgtca actggaccaa tgagaacttt       60

cctttcaatg attgcgtcga caagatggtg atctggtggg aggagggaaa gatgaccgcc      120

aaggtcgtgg agtcggccaa agccattctc ggaggaagca aggtgcgcgt ggaccagaaa      180

tgcaagtcct cggcccagat agacccgact cccgtgattg tcacctccaa caccgacatg      240

tgcgccgtga ttgacgggaa ctcaacgacc ttcgaacacc agcagccgtt gcaagaccgg      300

atgttcaaat ttgaactcac ccgccgtctg gatcatgact ttgggaaggt caccaagcag      360

gaagtcaaag actttttccg gtgggcaaag gatcacgtgg ttgaggtgga gcatgaattc      420

tacgtcaaaa agggtggagc taagaaaaga cccgccccca gtgacgcaga tataagtgag      480

cccaaacggg cgcgcgagtc agttgcgcag ccatcgacgt cagacgcgga agcttcgatc      540

aactacgcgg acaggtacca aaacaaatgt tctcgtcacg tgggcatgaa tctgatgctg      600

tttccctgca gacaatgcga gagaatgaat cagaattcaa atatctgctt cactcacgga      660

cagaaagact gtttagagtg ctttcccgtg tcagaatctc aacccgtttc tgtcgtcaaa      720

aaggcgtatc agaaactttg ctacattcat catatcatgg gaaaggtgcc agacgcttgc      780

actgcctgcg atctggtcaa tgtggatttg gatgactgca tctctgaaca ataaatgatt      840

taaatcaggt atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga      900

aggaataaga cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg      960

gcataaggac gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa     1020

cggactcgac aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa     1080

ggcctacgac cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga     1140

cgcggagttt caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc     1200

agtcttccag gcaaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa     1260

aacggctccg ggaaaaaaga ggccggtaga gcaccctcct gtggagccag actcctcctc     1320

gggaaccgga aaagcgggcc agcagcctgc aagaaaaaga ttgaatttcg gtcagactgg     1380

agacgcagac tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg     1440

tctgggatct actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg     1500

tgccgatgga gtgggtaatt cctcgggaaa ttggcattgc gattcccaat ggctgggcga     1560

cagagtcatc accaccagca cccgcacctg ggccctgccc acctacaaca accacctcta     1620

caagcaaatc tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac     1680

cccctggggg tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca     1740

aagactcatc aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa     1800

cattcaagtc aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac     1860

cagcacggtt caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc     1920

gcatcaagga tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata     1980

cctcaccctg aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta     2040

ctttccttct cagatgctgc gtaccggaaa caactttcag ttcagctaca cttttgaaga     2100

cgtgcctttc cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct     2160

gatcgaccag tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca     2220

gtctcggcta ctgtttagcc aagctggacc caccaacatg tctcttcaag ctaaaaaccg     2280

gctgcctgga ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa     2340

cagcaacttt ccctggaccg cagctacaaa gtatcatcta aatggccggg actcgttggt     2400

taatccagga ccagctatgg ccagtcacaa ggatgacgaa gaaaagtttt tccccatgca     2460

tggaaccctt atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt     2520

catgattaca gatgaagaag aaatcaggac caccaatccc gtggctacgg agcagtacgg     2580

aactgtatca aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatca     2640

ccaaggagcg ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat     2700

ttgggccaag attcctcaca ccgatggaca ctttcatcct tctccactgg tgggaggttt     2760

tggactcaaa cacccacctc ctcaaatcat gatcaaaaac actcccgttc cagccaatcc     2820

tcccacaaac ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacggggca     2880

ggtcagcgtg gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga     2940

aattcagtac acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa     3000

tggtgtgtat tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaatt     3060

gcttgttaat caataaaccg tttaattcgt ttcagttgaa ctttggtctc tgcgaagggc     3120

gaattcgttt aaacctgcag gactagtccc tttagtgag                            3159


<210> 4967
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4967
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtaccttg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac cccaagtaca accacgccga cgcggagttc      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaatttcg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggctctgccc acctacaaca accacctcta caagcagatt      780

tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcgccac gtgactggca aagactcatc      900

aacaacaatt ggggattccg gcccaaaaga ctcaacttca agctctttaa cattcaagtc      960

aaggaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgcccacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctt aatggaagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtgtggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcccc cgcagattct catcaagaac accccggtac ctgcgaatcc ttcgactacc     1980

ttcagtgcgg caaagtttgc ttccttcatt acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga gattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccaggtac ctgactcgta atctgtaa                  2208


<210> 4968
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4968
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Pro Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4969
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4969
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtaccttg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acggcggaga caacccgtac ctcaagtaca accacgccga cgcggagttc      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctctt gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaggaga ttgaatttcg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggctctgccc acctacaaca accacctcta caggcagatt      780

tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcgccac gtgactggca aagactcatc      900

aacaacaatt ggggatcccg gcccaaaaga ctcaacttca agctctttaa cattcaagtc      960

aaggaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgcccacag ccagagtttg gaccgtctca tgaatcctct cgtcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctt aatggaagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtgtggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcccc cgcagattct catcaagaac accccggtac ctgcgaatcc ttcgactacc     1980

ttcagtgcgg caaagtttgc ttccttcatt acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga gattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4970
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4970
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Gly Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Leu Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Arg Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Arg Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Ser Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Val Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4971
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4971
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Ala Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Glu Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Cys Ala His Ser Gln Ser 
            420                 425                 430         


Ser Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Arg Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4972
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 4972
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcttggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaatgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcggcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacgacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210> 4973
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4973
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Leu 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Gly Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4974
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4974
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Pro Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4975
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4975
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Gly Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4976
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4976
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg gacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tcaagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcgggtcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtactggaaa caactttcag ttcagctaca cctttgaaga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa aacacaatca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagtc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctacctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcaccta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggacaatgt catgattaca     1680

gatgaagaag aaatccgcac caccaatccc gtggctacgg agcagtacgg atatgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggca tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tgggctcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaagagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4977
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 4977
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg atccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 4978
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4978
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaacaaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tcaagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcgggtcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtactggaaa caactttcag ttcagctaca cctttgaaga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa aacacaatca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagtc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctacctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtaccaccta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggacaatgt catgattaca     1680

gatgaagaag aaatccgcac caccaatccc gtggctacgg agcagtacgg atatgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggca tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tgggctcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaagagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4979
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 4979
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccacctg caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg agggagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac tgccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210> 4980
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4980
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Thr Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4981
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4981
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcatcaggac      120

aacagcaggg gtcttgtgct tcctgggtac aagtacctcg gaccctccaa cggactcgac      180

aaaggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc atcagcctgc gagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag cccccacaag tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc gaacgacaac cactactttg gctgcagcac cccctggggg      840

tattttgact tcaacagatt ccactgtcac ttctccccac gtgattggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtacccgctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccggctga tgaatcctct gatcgaccag     1320

tatctatatt atctgaacag gacacaatca aatagtggaa ctcttcagca gtctaggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctttcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggagcatgt tatgattaca     1680

gatgaagaag aaatcaggac caccaatcct gtggctacag agcagtacgg aaacgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actacagaaa atgtcaatca ccagggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgacggaca ctttcaccct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcaaatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggcca ggtcagcgtg     2040

gagattgagt gggagctgca gaaggagaac agcaaacgct ggaaccccga gatccagtat     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctt gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4982
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4982
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Gln Asp Asn Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Ser Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Cys Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Pro Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu His Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Asn Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Glu Asn Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Cys Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4983
<211> 2196
<212> DNA
<213> Adeno-associated virus

<400> 4983
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg caacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacga ggcggacgcc gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caagagcgtc tgcaagaaga tacgtccttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga gggtactcga gcctctgggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaagc ggccagtaga accggactcc agctcgggca tcggcaagtc aggccagcag      480

cccgcgaaaa agagactgaa ttttgggcag actggcgact cagagtcagt gcctgacccc      540

caacctctct cagaaccacc cgcaggtccc tctggtctgg gatctggtac aatggctgct      600

ggcggtggcg ctccaatggc agacaataac gaaggcgccg acggagtggg taatgtctca      660

ggaaattggc attgcgattc cacatggctg ggcgaccgag tcatcaccac cagcactcgg      720

acctgggccc tccccaccta caacaaccac ctctacaagc aaatctccaa cgggacctcg      780

ggaggcagca gcaacgacaa cacctacttt ggctacagca ccccctgggg gtattttgac      840

tttaacagat tccactgcca cttttcacca cgtgactggc agcgactcat caacaacaac      900

tgggggttcc ggcccaagaa gctcaacttc aagctcttca acatccaggt caaggaggtc      960

acccagaatg aaggcaccaa gaccatcgcc aataacctca ccagcacggt gcaggtcttt     1020

acggactcgg agtaccagct cccgtacgtg ctcggctctg cccaccaggg ctgcctgcct     1080

ccgttcccgg cggacgtgtt catgattccg cagtacgggt acctgacgct gaacaacggg     1140

agccaggccg tggggcgatc ctccttctac tgcctggagt actttccctc gcagatgctg     1200

agaacgggca acaactttac cttcagctac accttcgagg acgtgccctt ccacagcagc     1260

tacgcgcaca gccagagcct ggaccggctg atgaacccgc tgattgacca gtacctgtac     1320

tacctgtctc ggactcagac caacgggacc aatgccacgc agactctgtt gtttgctcag     1380

gccgggcctc agaacatgtc ggctcaggcc aagaactggc tgcctggtcc ttgctatcgg     1440

cagcagcgcg tctctacgac agtgtcgcaa aacaacaaca gcaactttac ctggaccggg     1500

gcgaccaagt accacctgaa cggccgagac tccctggtga gccccggtgt cgccatggca     1560

acgcacaagg acgacgagga gcgcttcttc ccgagcagcg gggtcctgat gtttggcaag     1620

cagggcgctg gaaaggacaa tgtcgagtac accaacgtga tgctcaccag cgaggaggag     1680

atcaagacca ccaaccctgt ggccacggag cagtacggcg tggtggctga caatctgcag     1740

cagaccaact cagctcccat tgtgggggca gtcaacagcc agggggcctt acccggtatg     1800

gtctggcaga accgggacgt gtacctgcag ggtcccatct gggccaagat cccgcatacg     1860

gacggcaact ttcacccgtc tcctctcatg ggcggctttg gactgaaaca cccgcctccc     1920

cagatcctga tcaaaaacac gccggtacct gcggatcccc cggtgaactt tacggacgct     1980

aagctggcga gtttcatcac gcagtacagc accgggcagg tcagcgtgga gattgagtgg     2040

gagctgcaga aggagaacag caagcgctgg aatcccgaga ttcagtacac ttccaattat     2100

tataaatcag ctaatgtgga ctttgccgtc aatgcagatg gtgtatatag tgaaccccgc     2160

cccattggca ctcgttacct cacccgtaat ctgtaa                               2196


<210> 4984
<211> 731
<212> PRT
<213> Adeno-associated virus

<400> 4984
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys Ser Gly Gln Gln 
145                 150                 155                 160 


Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu Ser 
                165                 170                 175     


Val Pro Asp Pro Gln Pro Leu Ser Glu Pro Pro Ala Gly Pro Ser Gly 
            180                 185                 190         


Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala Asp 
        195                 200                 205             


Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Val Ser Gly Asn Trp His 
    210                 215                 220                 


Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg 
225                 230                 235                 240 


Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser 
                245                 250                 255     


Asn Gly Thr Ser Gly Gly Ser Ser Asn Asp Asn Thr Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Thr Asn 
        435                 440                 445             


Gly Thr Asn Ala Thr Gln Thr Leu Leu Phe Ala Gln Ala Gly Pro Gln 
    450                 455                 460                 


Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg 
465                 470                 475                 480 


Gln Gln Arg Val Ser Thr Thr Val Ser Gln Asn Asn Asn Ser Asn Phe 
                485                 490                 495     


Thr Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu 
            500                 505                 510         


Val Ser Pro Gly Val Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg 
        515                 520                 525             


Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly Ala Gly 
    530                 535                 540                 


Lys Asp Asn Val Glu Tyr Thr Asn Val Met Leu Thr Ser Glu Glu Glu 
545                 550                 555                 560 


Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala 
                565                 570                 575     


Asp Asn Leu Gln Gln Thr Asn Ser Ala Pro Ile Val Gly Ala Val Asn 
            580                 585                 590         


Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr 
        595                 600                 605             


Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe 
    610                 615                 620                 


His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro 
625                 630                 635                 640 


Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Val Asn 
                645                 650                 655     


Phe Thr Asp Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
            660                 665                 670         


Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
        675                 680                 685             


Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Ala 
    690                 695                 700                 


Asn Val Asp Phe Ala Val Asn Ala Asp Gly Val Tyr Ser Glu Pro Arg 
705                 710                 715                 720 


Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730     


<210> 4985
<211> 2196
<212> DNA
<213> Adeno-associated virus

<400> 4985
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg caacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacga ggcggacgcc gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caagagcgtc tgcaagaaga tacgtccttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga gggtactcga gcctctgggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaagc ggccagtaga accggactcc agctcgggca tcggcaagtc aggccggcag      480

cccgcgaaaa agagactgaa ttttgggcag actggcgact cagagtcagt gcctgacccc      540

caacctctct cagaaccacc cgcaggtccc tctggtctgg gatctggtac aatggctgca      600

ggcggtggcg ctccaatggc agacaataac gaaggcgccg acggagtggg taatgcctca      660

ggaaattggc attgcgattc cacatggctg ggcgaccgag tcatcaccac cagcactcgg      720

acctgggccc tccccaccta caacaaccac ctctacaagc aaatctccaa cgggacctcg      780

ggaggcagca gcaacgacaa cacctacttt ggctacagca ccccctgggg gtattttgac      840

tttaacagat tccactgcca cttttcacca cgtgactggc agcgactcat caacaacaac      900

tggggattcc ggcccaagag gctcaacttc aagctcttca acatccaggt caaggaggtc      960

acccagaatg aaggcaccaa gaccatcgcc aataacctca ccagcacggt gcaggtcttt     1020

acggactcga agtaccagct cccgtacgtg ctcggctctg cccaccaggg ctgcctgcct     1080

ccgttcccgg cggacgtgtt catgattccg cagtacgggt acctgacgct gaacaacggg     1140

agccaggccg tggggcgatc ctccttctac tgcctggagt actttccctc gcagatgctg     1200

agaacgggca acaactttac cttcagctac accttcgagg acgtgccctt ccacagcagc     1260

tacgcgcaca gccagagcct ggaccggctg atgaacccgc tgattgacca gtacctgtac     1320

tacctgtctc ggactcagac caacgggacc aatgccacgc agactctgtt gtttgctcag     1380

gccgggcctc agaacatgtc ggctcaggcc aagaactggc tgcctggtcc ttgctatcgg     1440

cagcagcgcg tctctacgac agtgtcgcaa aacaacaaca gcaactttac ctggaccggg     1500

gcgaccaagt accacctgaa cggccgagac tccctggtga accccggtgt cgccatggca     1560

acgcacaagg acgacgagga gcgcttcttc ccgagcagcg gggtcctgat gtttggcaag     1620

cagggcgctg gaaaggacaa tgtcgagtac accaacgtga tgctcaccag cgaggaggag     1680

atcaagacca ccaaccctgt ggccacggag cagtacggtg tggtggctga caatctgcag     1740

cagaccaact cggctcccat tgtgggggca gtcaacagcc agggggcctt acccggtatg     1800

gtctggcaga accgggacgt gtacctgcag ggtcccatct gggccaagat cccgcatacg     1860

gacggcaact ttcacccgtc tcctctcatg ggcggctttg gactgaaaca cccgcctccc     1920

cagatcctga tcaaaaacac gccggtacct gcggatcccc cggtgaactt tacggacgct     1980

aagctggcga gtttcatcac gcagtacagc accgggcagg tcagcgtgga gattgagtgg     2040

gagctgcaga aggagaacag caagcgctgg aatcccgaga ttcagtacac ttccaattat     2100

tataaatcag ctaatgtgga ctttgccgtc aatgcagatg gtgtatatag tgaaccccgc     2160

cccattggca ctcgttacct cacccgtaat ctgtaa                               2196


<210> 4986
<211> 731
<212> PRT
<213> Adeno-associated virus

<400> 4986
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys Ser Gly Arg Gln 
145                 150                 155                 160 


Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu Ser 
                165                 170                 175     


Val Pro Asp Pro Gln Pro Leu Ser Glu Pro Pro Ala Gly Pro Ser Gly 
            180                 185                 190         


Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala Asp 
        195                 200                 205             


Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp His 
    210                 215                 220                 


Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg 
225                 230                 235                 240 


Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser 
                245                 250                 255     


Asn Gly Thr Ser Gly Gly Ser Ser Asn Asp Asn Thr Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Thr Asp Ser Lys Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Thr Asn 
        435                 440                 445             


Gly Thr Asn Ala Thr Gln Thr Leu Leu Phe Ala Gln Ala Gly Pro Gln 
    450                 455                 460                 


Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg 
465                 470                 475                 480 


Gln Gln Arg Val Ser Thr Thr Val Ser Gln Asn Asn Asn Ser Asn Phe 
                485                 490                 495     


Thr Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu 
            500                 505                 510         


Val Asn Pro Gly Val Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg 
        515                 520                 525             


Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly Ala Gly 
    530                 535                 540                 


Lys Asp Asn Val Glu Tyr Thr Asn Val Met Leu Thr Ser Glu Glu Glu 
545                 550                 555                 560 


Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala 
                565                 570                 575     


Asp Asn Leu Gln Gln Thr Asn Ser Ala Pro Ile Val Gly Ala Val Asn 
            580                 585                 590         


Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr 
        595                 600                 605             


Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe 
    610                 615                 620                 


His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro 
625                 630                 635                 640 


Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Val Asn 
                645                 650                 655     


Phe Thr Asp Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
            660                 665                 670         


Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
        675                 680                 685             


Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Ala 
    690                 695                 700                 


Asn Val Asp Phe Ala Val Asn Ala Asp Gly Val Tyr Ser Glu Pro Arg 
705                 710                 715                 720 


Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730     


<210> 4987
<211> 2196
<212> DNA
<213> Adeno-associated virus

<400> 4987
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg caacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacga ggcggacgcc gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caagagcgtc tgcaagaaga tacgtccttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga gggtactcga gcctctgggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaagc ggccagtaga accggactcc agctcgggca tcggcaagtc aggccagcag      480

cccgcgaaaa agagactgaa ttttgggccg actggcgact cagagtcagt gcctgacccc      540

caacctctct cagaaccacc tgcaggtccc tctggtctgg gatctggtac aatggctgca      600

ggcggtggcg ctccaatggc agacaataac gaaggcgccg acggagtggg taatgtctca      660

ggaaattggc attgcgattc cacatggctg ggcgaccgag tcatcaccac cagcactcgg      720

acctgggccc tccccaccta caacaaccac ctctacaagc aaatctccaa cgggacctcg      780

ggaggcagca gcaacgacaa cacctacttt ggctacagca ccccctgggg gtattttgac      840

tttaacagat tccactgcca cttttcacca cgcgactggc agcgactcat caacaacaac      900

tggggattcc ggcccaagaa gctcaacttc aagctcttca acatccaggt caaggaggtc      960

acccagaatg aaggcaccaa gaccaccgcc aataacctca ccagcacggt gcaggtcttt     1020

acggactcgg agtaccagct cccgtacgtg ctcggctctg cccaccaggg ctgcctgcct     1080

ccgttcccgg cggacgtgtt catgattccg cagtacgggt acctgacgct gaacaacggg     1140

agccaggccg tggggcgatc ctccttctac tgcctggagt actttccctc gcagatgctg     1200

agaacgggca acaactttac cttcagctac accttcgagg acgtgccctt ccacagcagc     1260

tacgcgcaca gccagagcct ggaccggctg atgaacccgc tgattgacca gtacctgtac     1320

tacctgtctc ggactcagac caacgggacc aatgccacgc agactctgtt gtttgctcag     1380

gccgggcctc agaacatgtc ggctcaggcc aagaactggc tgcctggtcc ttgctatcgg     1440

cagcagcgcg tctctacggc agtgtcgcaa aacaacaaca gcaactttac ctggaccggg     1500

gcgaccaagt accacctgaa cggccgagac tccctggtga accccggtgt cgccatggca     1560

acgcacaagg acgacgagga gcgcttcttc ccgagcagcg gggtcctgat gtttggcaag     1620

cagggcgctg gaaaggacaa tgtcgagtac accaacgtga tgctcaccag cgaggaggag     1680

atcaagacca ccaaccctgt ggccacggag cagtacggtg tggtggctga caatctgcag     1740

cagaccaact cggctcccat tgtgggggca gtcaacagcc agggggcctt acccggtatg     1800

gtctggcaga accgggacgt gtacctgcag ggtcccatct gggccaagat cccgcatacg     1860

gacggcaact ttcacccgtc tcctctcatg ggcggctttg gactgaaaca cccgcctccc     1920

cagatcctga tcaaaaacac gccggtacct gcggatcccc cggtgaactt tacggacgct     1980

aagctggcga gtttcatcac gcagtacagc accgggcagg tcagcgtgga gattgagtgg     2040

gagctgcaga aggagaacag caagcgctgg aatcccgaga ttcagtacac ttccaattat     2100

tataaatcag ctaatgtgga ctttgccgtc aatgcagatg gtgtatatag cgaaccccgc     2160

cccattggca ctcgttacct cacccgtaat ctgtaa                               2196


<210> 4988
<211> 731
<212> PRT
<213> Adeno-associated virus

<400> 4988
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys Ser Gly Gln Gln 
145                 150                 155                 160 


Pro Ala Lys Lys Arg Leu Asn Phe Gly Pro Thr Gly Asp Ser Glu Ser 
                165                 170                 175     


Val Pro Asp Pro Gln Pro Leu Ser Glu Pro Pro Ala Gly Pro Ser Gly 
            180                 185                 190         


Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala Asp 
        195                 200                 205             


Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Val Ser Gly Asn Trp His 
    210                 215                 220                 


Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg 
225                 230                 235                 240 


Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser 
                245                 250                 255     


Asn Gly Thr Ser Gly Gly Ser Ser Asn Asp Asn Thr Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Gln Asn Glu Gly Thr Lys Thr Thr Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Thr Asn 
        435                 440                 445             


Gly Thr Asn Ala Thr Gln Thr Leu Leu Phe Ala Gln Ala Gly Pro Gln 
    450                 455                 460                 


Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg 
465                 470                 475                 480 


Gln Gln Arg Val Ser Thr Ala Val Ser Gln Asn Asn Asn Ser Asn Phe 
                485                 490                 495     


Thr Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu 
            500                 505                 510         


Val Asn Pro Gly Val Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg 
        515                 520                 525             


Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly Ala Gly 
    530                 535                 540                 


Lys Asp Asn Val Glu Tyr Thr Asn Val Met Leu Thr Ser Glu Glu Glu 
545                 550                 555                 560 


Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala 
                565                 570                 575     


Asp Asn Leu Gln Gln Thr Asn Ser Ala Pro Ile Val Gly Ala Val Asn 
            580                 585                 590         


Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr 
        595                 600                 605             


Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe 
    610                 615                 620                 


His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro 
625                 630                 635                 640 


Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Val Asn 
                645                 650                 655     


Phe Thr Asp Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
            660                 665                 670         


Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
        675                 680                 685             


Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Ala 
    690                 695                 700                 


Asn Val Asp Phe Ala Val Asn Ala Asp Gly Val Tyr Ser Glu Pro Arg 
705                 710                 715                 720 


Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730     


<210> 4989
<211> 4404
<212> DNA
<213> Adeno-associated virus

<400> 4989
atggctgccg atggttatct tccagattgg ctcgagggca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aggtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

aagcagctcg agcaggggga caacccgtac ctcaagtaca accacgccga cgccgagttt      300

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gacccataga atcccccgac tcctccacgg gcatcggcaa gaacggccag      480

ccgcccgcta aaaagaagct caactttggg cagactggcg actcagagtc agtgcccgac      540

ccccaacctc tcggagaacc tcccgccgcg ccctcaggtc tgggatctgg tacaatggct      600

gcaggcggtg gcgcaccaat ggcagacaat aacgaaggcg ccgacggagt gggtaatgcc      660

tccggaaatt ggcattgcga ttccacatgg ctgggcgaca gagtcatcac caccagcacc      720

cgcacctggg ccctgcccac ctacaacaac cacctctaca agcagatatc aagtcagagc      780

ggggctacca acgacaacca cttcttcggc tacagcaccc cctggggcta ttttgacttc      840

aacagattcc actgccactt ctcaccacgt gactggcagc gactcatcaa caacaactgg      900

ggattccggc ccagaaagct gcggttcaag ttgttcaaca tccaggtcaa ggaggtcacg      960

acgaacgacg gcgttacgac catcgctaat aaccttacca gcacgattca ggtcttctcg     1020

gactcggagt accaactgcc gtacgtcctc ggctctgcgc accagggctg cctccctccg     1080

ttccctgcgg acgtgttcat gattcctcag tacggatatc tgactctaaa caacggcagt     1140

cagtctgtgg gacgttcctc cttctactgc ctggagtact ttccttctca gatgctgaga     1200

acgggcgata actttgaatt cagctacacc tttgaggaag tgcctttcca cagcagctat     1260

gcgcacagcc agagcctgga ccggctgatg aatcccctca tcgaccagta cctgtactac     1320

ctggcccgga cccagagcac tacggggtcc acaagggagc tgcagttcca tcaggctggg     1380

cccaacacca tggccgagca atcaaagaac tggctgcccg gaccctgtta tcggcagcag     1440

agactgtcaa aaaacataga cagcaacaac aacagtaact ttgcctggac cggggccact     1500

aaataccatc tgaatggtag aaattcatta accaacccgg gcgtagccat ggccaccaac     1560

aaggacgacg aggaccagtt ctttcccatc aacggagtgc tggtttttgg caaaacgggg     1620

gctgccaaca agacaacgct ggaaaacgtg ctaatgacca gcgaggagga gatcaaaacc     1680

accaatcccg tggctacaga agaatacggt gtggtctcca gcaacctgca atcgtctacg     1740

gccggacccc agacacagac tgtcaacagc cagggggctc tgcccggcat ggtctggcag     1800

aaccgggacg tgtacctgca gggtcccatc tgggccaaaa ttcctcacac ggacggcaac     1860

tttcacccgt ctcccctgat gggcggattt ggactcaaac acccgcctcc tcaaattctc     1920

atcaaaaaca ccccggtacc tgctaatcct ccagaggtgt ttactcctgc caagtttgcc     1980

tcatttatca cgcagtacag caccggccag gtcagcgtgg agatcgagtg ggaactgcag     2040

aaagaaaaca gcaaacgctg gaatccagag attcagtaca cctcaaatta tgccaagtct     2100

aataatgtgg aatttgctgt caacaacgaa ggggtttata ctgagcctcg ccccattggc     2160

acccgttacc tcacccgtaa cctgtaaatg gctgccgatg gttatcttcc agattggctc     2220

gaggacaacc tctctgaggg cattcgcgag tggtgggact tgaaacctgg agccccgaaa     2280

cccaaagcca accagcaaaa gcaggacgac ggccggggtc tggtgcttcc tggctacaag     2340

tacctcggac ccttcaacgg actcgacaag ggggagcccg tcaacgcggc ggacgcagcg     2400

gccctcgagc acgacaaggc ctacgaccag cagctcaaag cgggtgacaa tccgtacctg     2460

cggtataacc acgccgacgc cgagtttcag gagcgtctgc aagaagatac gtcttttggg     2520

ggcaacctcg ggcgagcagt cttccaggcc aagaagcggg ttctcgaacc tctcggtctg     2580

gttgaggaag gcgctaagac ggctcctgga aagaagagac cggtagagcc atcaccccag     2640

cgttctccag actcctctac gggcatcggc aagaaaggcc agcagcccgc gaaaaagaga     2700

ctcaactttg ggcagactgg cgactcagag tcagtgcccg accctcaacc aatcggagaa     2760

ccccccgcag gcccctctgg tctgggatct ggtacaatgg ctgcaggcgg tggcgctcca     2820

atggcagaca ataacgaagg cgccgacgga gtgggtagtt cctcaggaaa ttggcattgc     2880

gattccacat ggctgggcga cagagtcatc accaccagca cccgaacctg ggccctcccc     2940

acctacaaca accacctcta caagcaaatc tccaacggga cttcgggagg aagcaccaac     3000

gacaacacct acttcggcta cagcaccccc tgggggtatt ttgactttaa cagattccac     3060

tgccacttct caccacgtga ctggcagcga ctcatcaaca acaactgggg attccggccc     3120

aagagactca acttcaagct cttcaacatc caggtcaagg aggtcacgca gaatgaaggc     3180

accaagacca tcgccaataa ccttaccagc acgattcagg tctttacgga ctcggaatac     3240

cagctcccgt acgtcctcgg ctctgcgcac cagggctgcc tgcctccgtt cccggcggac     3300

gtcttcatga ttcctcagta cgggtacctg actctgaaca atggcagtca ggccgtgggc     3360

cgttcctcct tctactgcct ggagtacttt ccttctcaaa tgctgagaac gggcaacaac     3420

tttgagttca gctaccagtt tgaggacgtg ccttttcaca gcagctacgc gcacagccaa     3480

agcctggacc ggctgatgaa ccccctcatc gaccagtacc tgtactacct gtctcggact     3540

cagtccacgg gaggtaccgc aggaactcag cagttgctat tttctcaggc cgggcctaat     3600

aacatgtcgg ctcaggccaa aaactggcta cccgggccct gctaccggca gcaacgcgtc     3660

tccacgacac tgtcgcaaaa taacaacagc aactttgcct ggaccggtgc caccaagtat     3720

catctgaatg gcagagactc tctggtaaat cccggtgtcg ctatggcaac ccacaaggac     3780

gacgaagagc gattttttcc gtccagcgga gtcttaatgt ttgggaaaca gggagctgga     3840

aaagacaacg tggactatag cagcgttatg ctaaccagtg aggaagaaat taaaaccacc     3900

aacccagtgg ccacagaaca gtacggcgtg gtggccgata acctgcaaca gcaaaacgcc     3960

gctcctattg taggggccgt caacagtcaa ggagccttac ctggcatggt ctggcagaac     4020

cgggacgtgt acctgcaggg tcctatctgg gccaagattc ctcacacgga cggaaacttt     4080

catccctcgc cgctgatggg aggctttgga ctgaaacacc cgcctcctca gatcctgatt     4140

aagaatacac ctgttcccgc ggatcctcca actaccttca gtcaagctaa gctggcgtcg     4200

ttcatcacgc agtacagcac cggacaggtc agcgtggaaa ttgaatggga gctgcagaaa     4260

gaaaacagca aacgctggaa cccagagatt caatacactt ccaactacta caaatctaca     4320

aatgtggact ttgctgttaa cacagatggc acttattctg agcctcgccc catcggcacc     4380

cgttacctca cccgtaatct gtaa                                            4404


<210> 4990
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4990
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4991
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4991
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4992
<211> 2501
<212> DNA
<213> Adeno-associated virus

<400> 4992
gaattcgccc ttggctgcgt caactggacc aatgagaact ttcccttcaa cgattgcgtc       60

gacaagatgg tgatctggtg ggaggagggc aagatgacgg ccaaggtcgt ggagtccgcc      120

aaggccattc atcatctgct ggggcgggct cccgagattg cttgctcggc ctgcgatctg      180

gtcaacgtgg acctggatga ctgtgtttct gagcaataaa tgacttaaac caggtatggc      240

tgccgatggt tatcttccag attggctcga ggacaacctc tctgagggca ttcgcgagtg      300

gtgggacttg agacctggag ccccgaaacc caaagccaac cagcaaaagc aggacgacgg      360

ccggggtctg gtgcttcctg gctacaagta cctcggaccc ttcaacggac tcgacaaggg      420

agagccggtc aacgaggcag acgccgcggc cctcgagcac gacaaggcct acgacaagca      480

gctcgagcag ggggacaacc cgtacctcaa gtacaaccac gccgacgccg agtttcagga      540

gcgtcttcaa gaagatacgt cttttggggg caacctcggg cgagcagtct tccaggccaa      600

gaagcgggtt ctcgaacctc tcggtctggt tgaggaaggc gctaagacgg ctcctggaaa      660

gaagagaccc atagaatccc ccgactcctc cacgggcatc ggcaagaaag gccagcagcc      720

cgctaaaaag agactcaact ttgggcagac tggcgactca gagtcagtgc ccgaccctca      780

accaatcgga gaaccccccg caggcccctc tggtctggga tctggcacaa tggctgcagg      840

cggtggcgct ccaatggcag acaataacga aggcgccgac ggagtgggta gttcctcagg      900

aaattggcat tgcgattcca catggctggg cgacagagtc atcaccacca gcacccgaac      960

ctgggccctc cccacctaca acaaccacct ctacaagcaa atctccaacg ggacatcggg     1020

aggaagcacc aacgacaaca cctacttcgg ctacagcacc ccctgggggt attttgactt     1080

taacagattc cactgccact tctcaccacg tgactggcag cgactcatca acaacaactg     1140

gggattccgg cccaagagac tcaacttcaa gctcttcaac atccaggtca aggaggtcac     1200

gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc agcacgattc aggtctttac     1260

ggactcggaa taccagctcc cgtacgtcct cggctctgcg caccagggct gcctgcctcc     1320

gttcccggcg gacgtcttca tgattcctca gtacgggtac ctgactctga acaacggcag     1380

tcaggccgtg ggccgttcct ccttctactg cctggagtac tttccttctc aaatgctgag     1440

aacgggcaac aactttgagt tcagctacca gtttgaggac gtgccttttc acagcagcta     1500

tgcgcacagc caaagcctgg accggctgat gaaccccctc atcgaccagt acctgtacta     1560

cctgtctcgg actcagtcca cgggaggtac cgcaggaact cagcagttgc tattttctca     1620

ggccgggcct aataacatgt cggctcaggc caaaaactgg ctacccgggc cctgctaccg     1680

gcagcaacgc gtctccacga cagtgtcgca aaataacaac agcaactttg cttggaccgg     1740

tgccaccaag tatcatctga atggcagaga ctctctggta aatcccggtg tcgctatggc     1800

aacgcacaag ggcgacgaag agcgattttt tccatccagc ggagtcttga tgtttgggaa     1860

acagggagct ggaaaagaca acgtagacta tagcagcgtt atgctaacca gtgaggaaga     1920

aatcaaaacc accaacccag tggccacaga acagtacggc gtggtggccg ataacctgca     1980

acagcaaaac gccgctccta ttgtaggggc cgtcaacagt caaggagcct tacctggcat     2040

ggtctggcag aaccgggacg tgtacctgca gggtcctatc tgggccaaga ttcctcacac     2100

ggacggcaac tttcatcctt cgccgctgat gggaggcttt ggactgaaac acccgcctcc     2160

tcagatcctg attaagaata cacctgttcc cgcggatcct ccaactacct tcagtcaagc     2220

caagctggcg tcgttcatca cgcagtacag caccggacag gtcagcgtgg aaattgaatg     2280

ggagctgcag aaagagaaca gcaagcgctg gaacccagag attcagtata cttccaacta     2340

ctacaaatct acaaatgtgg actttgctgt caatactgag ggtacttatt cagagcctcg     2400

ccccattggc acccgttacc tcacccgtaa cctgtaattg cctgttaatc aataaaccgg     2460

ttgattcgtt tcagttgaac tttggtctca agggcgaatt c                         2501


<210> 4993
<211> 2187
<212> DNA
<213> Adeno-associated virus

<400> 4993
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

aagcagctcg agcaggggga caacccgtac ctcaagtaca accacgccga cgccgagttt      300

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gacccataga atcccccgac tcctccacgg gcatcggcaa gaaaggccag      480

cagcccgcta aaaagaagct caactttggg cagactggcg actcagagtc agtgcccgac      540

ccccaacctc tcggagaacc tcccgccgcg ccctcaggtc tgggatctgg tacaatggct      600

gcaggcggtg gcgcaccaat ggcagacaat aacgaaggcg ccgacggagt gggtaatgcc      660

tccggaaatt ggcattgcga ttccacatgg ctgggcgaca gagtcatcac caccagcacc      720

cgcacctggg ccctgcccac ctacaacaac cacctctaca agcagatatc aagtcagagc      780

ggggctacca acgacaacca cttcttcggc tacagcaccc cctggggcta ttttgacttc      840

aacagattcc actgccactt ctcaccacgt gactggcagc gactcatcaa caacaactgg      900

ggattccggc ccagaaagct gcggttcaag ttgttcaaca tccaggtcaa ggaggtcacg      960

acgaacgacg gcgttacgac catcgctaat aaccttacca gcacgattca ggtcttctcg     1020

gactcggagt accaactgcc gtacgtcctc ggctctgcgc accagggctg cctccctccg     1080

ttccctgcgg acgtgttcat gattcctcag tacggatatc tgactctaaa caacggcagt     1140

cagtctgtgg gacgttcctc cttctactgc ctggagtact ttccttctca gatgctgaga     1200

acgggcaata actttgaatt cagctacacc tttgaggaag tgcctttcca cagcagctat     1260

gcgcacagcc agagcctgga ccggctgatg aatcccctca tcgaccagta cctgtactac     1320

ctggcccgga cccagagcac tacggggtcc acaagggagc tgcagttcca tcaggctggg     1380

cccaacacca tggccgagca atcaaagaac tggctgcccg gaccctgtta tcggcagcag     1440

agactgtcaa aaaacataga cagcaacaac aacagtaact ttgcctggac cggggccact     1500

aaataccatc tgaatggtag aaattcatta accaacccgg gcgtagccat ggccaccaac     1560

aaggacgacg aggaccagtt ctttcccatc aacggagtgc tggtttttgg cgaaacgggg     1620

gctgccaaca agacaacgct ggaaaacgtg ctaatgacca gcgaggagga gatcaaaacc     1680

accaatcccg tggctacaga agaatacggt gtggtctcca gcaacctgca atcgtctacg     1740

gccggacccc agacacagac tgtcaacagc cagggggctc tgcccggcat ggtctggcag     1800

aaccgggacg tgtacctgca gggtcccatc tgggccaaaa ttcctcacac ggacggcaac     1860

tttcacccgt ctcccctgat gggcggattt ggactcaaac acccgcctcc tcaaattctc     1920

atcaaaaaca ccccggtacc tgctaatcct ccagaggtgt ttactcctgc caagtttgcc     1980

tcatttatca cgcagtacag caccggccag gtcagcgtgg agatcgagtg ggaactgcag     2040

aaagaaaaca gcaaacgctg gaatccagag attcagtaca cctcaaatta tgccaagtct     2100

aataatgtgg aatttgctgt caacaacgaa ggggtttata ctgagcctcg ccccattggc     2160

acccgttacc tcacccgtaa cctgtaa                                         2187


<210> 4994
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4994
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Glu Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4995
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4995
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4996
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4996
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4997
<211> 3113
<212> DNA
<213> Adeno-associated virus

<400> 4997
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga tcccaccccc gtgatcgtca cttccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttaca agaccggatg ttcaaatttg      300

aactcacccg ccgtctggag catgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg cttccctgca      600

agacatgcga gagaatgaat cagaatttca gcatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtca tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagacccat agaatccccc gactcctcca cgggcatcgg caagaaaggc     1320

cagcagcccg ctaaaaagaa gctcaacttt gggcagactg gcgactcaga gtcagtgccc     1380

gaccctcaac caatcggaga accccccgca ggcccctctg gtctgggatc tggtacaatg     1440

gctgcaggcg gtggcgctcc aatggcagac aataacgaag gcgccgacgg agtgggtagt     1500

tcctcaggaa attggcattg cgattccaca tagctgggcg acagagtcat caccaccagc     1560

acccgaacct gggccctccc cacctacaac aaccacctct acaagcaaat ctccaacggg     1620

acatcgggag gaagcaccaa cgacaacacc tacttcggct acagcacccc ctgggggtat     1680

tttgacttta acagattcca ctgccacttc tcaccacgtg actggcagcg actcatcaac     1740

aacagctggg gattccggcc caagagactc aacttcaagc tcttcaacat ccaggtcaag     1800

gaggtcacgc agaatgaagg caccaagacc atcgccaata accttaccag cacgattcag     1860

gtctttacgg actcggaata ccagctcccg tacgtcctcg gctctgcgca ccagggctgc     1920

ctgcctccgt tcccggcgga cgtcttcatg attcctcagt acgggtacct gactctgaac     1980

aacggcagtc aggccgtggg ccgttcctcc ttctactgcc tggagtactt tccttctcaa     2040

atgctgagaa cgggcaacaa ctttgagttc agctaccagt ttgaggacgt gccttttcac     2100

agcagctacg cgcacagcca aagcctggac cggctgatga accccctcat cgaccagtac     2160

ctgtactacc tgtctcggac tcagtccacg ggaggtaccg caggaactca gcagttgcta     2220

ttttctcagg ccgggcctaa taacatgtcg gctcaggcca aaaactggct acccgggccc     2280

tgctaccggc agcaacgcgt ctccacgaca ctgtcgcaaa ataacaacag caactttgct     2340

tggaccggtg ccaccaagta tcatctgaat ggcagagact ctctggtaaa tcccggtgtc     2400

gctatggcaa cgcacaagga cgacgaagag cgattttttc catccagcgg agtcttgatg     2460

tttgggaaac agggagctgg aaaagacaac gtggactata gcagcgttat gctaaccagt     2520

gaggaagaaa tcaaaaccac caacccagtg gccacagaac agtacggcgt ggtggccgat     2580

aacctgcaac agcaaaacgc cgctcctatt gtaggggccg tcaacagtca aggagcctta     2640

cctggcatgg tctggcagaa ccgggacgtg tacctgcagg gtcctatctg ggccaagatt     2700

cctcacacgg acggcaactt tcatccttcg ccgctgatgg gaggctttgg actgaaacac     2760

ccgcctcctc agatcctgat taagaataca cctgttcccg cggatcctcc aactaccttc     2820

agtcaagcca agctggcgtc gttcatcacg cagtacagca ccggacaggt cagcgtggaa     2880

attgaatggg agctgcagaa agagaacagc aagcgctgga acccagagat tcagtatact     2940

tccaactact acaaatctac aaatgtggac tttgctgtca atactgaggg tacttattca     3000

gagcctcgcc ccattggcac ccgttacctc acccgtaacc tgtaattgcc tgttaatcaa     3060

taaaccggtt aattcgtttc agttgaactt tggtctctgc gaagggcgaa ttc            3113


<210> 4998
<211> 3106
<212> DNA
<213> Adeno-associated virus

<400> 4998
gaattcgccc ttctacggct gcgtcaactg gaccaatgag aactttccct tcaacgattg       60

cgtcgacaag atggtgatct ggtgggagga gggcaagatg acggccaagg tcgtggagtc      120

cgccaaggcc attctcggcg gcagcaaggt gcgcgtggac caaaagtgca agtcgtccgc      180

ccagatcgac cccacccccg tgatcgtcac ctccaacacc aacatgtgcg ccgtgattga      240

cgggaacagc accaccttcg agcaccagca gccgttgcag gaccggatgt tcaaatttga      300

actcacccgc cgtctggagc atgactttgg caaggcgaca aagcaggaag tcaaagagtt      360

cttccgctgg gcgcaggatc acgtgaccga ggtggcgcat gagttctacg tcagaaaggg      420

tggagccaac aagagacccg cccccgatga cgcggataaa agcgagccca agcgggcccg      480

cccctcagtc gcggatccat cgacgtcaga cgcggaagga gctccggtgg actttgccga      540

caggtaccaa aacaaatgtt ctcgtcacgc gggcatgctt cagatgctgt ttccctgcaa      600

aacatgcgag agaatgaatc agaatttcaa catttgcttc acgcacggga ccagagactg      660

ttcagaatgt ttccccggcg tgtcagaatc tcaaccggtc gtcagaaaga ggacgtatcg      720

gaaactctgt gccattcatc atctgctggg gcgggctccc gagattgctt gctcggcctg      780

cgatctggtc aacgtggacc tggatgactg tgtttctgag caataaatga cttaaaccag      840

gtatggctgc cgatggttat cttccagatt ggctcgagga caacctctct gagggcattc      900

gcgagtggtg ggacttgaaa cctggagccc cgaaacccaa agccaaccag caaaagcagg      960

acgacggccg gggtctggtg cttcctggct acaagtacct cggacccttc aacggactcg     1020

acaagggaga gccggtcaac gaggcagacg ccgcggccct cgagcacgac aaggcctacg     1080

acaagcagct cgagcagggg gacaacccgt acctcaagta caaccacgcc gacgccgagt     1140

ttcaggagcg tcttcaagaa gatacgtctt ttgggggcaa cctcgggcga gcagtcttcc     1200

gggccaagaa gcgggttctc gaacctctcg gtctggttga ggaaggcgct aagacggctc     1260

ctggaaagaa gagacccata gaatcccccg actcctccac gggcatcggc aagaaaggcc     1320

agcagcccgc taaaaagaag ctcaactttg ggcagactgg cgactcagag tcagtgcccg     1380

acccccaacc tctcggagaa cctcccgccg cgccctcagg tctgggatct ggtacaatgg     1440

ctgcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga gtgggtaatg     1500

cctccggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc accaccagca     1560

cccgcacctg ggccctgccc acctacaaca accacctcta caagcagata tcaagtcaga     1620

gcggggctac caacgacaac cacttcttcg gctacagcac cccctggggc tattttgact     1680

tcaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatc aacaacaacc     1740

ggggattccg gcccagaaag ctgcggttca agttgttcaa catccaggtc aaggaggtca     1800

cgacgaacga cggcgttacg accatcgcta ataaccttac cagcacgatt caggtcttct     1860

cggactcgga gtaccaactg ccgtacgtcc tcggctctgc gcaccagggc tgcctccctc     1920

cgttccctgc ggacgtgttc atgattcctc agtacggata tctgactcta aacaacggca     1980

gtcagtctgt gggacgttcc tccttctact gcctggagta ctttccttct cagatgctga     2040

gaacgggcaa taactttgaa ttcagctacc agtttgagga cgtgcccttt cacagcagct     2100

acgcgcacag ccaaagcctg gaccggctga tgaaccccct catcgaccag tacctgtact     2160

acctgtctcg gactcagtcc acgggaggta ccgcaggaac tcagcagttg ctattttctc     2220

aggccgggcc taataacatg tcggctcagg ccaaaaactg gctacccggg ccctgctacc     2280

ggcagcaacg cgtctccacg acactgtcgc aaaataacaa cagcaacttt gcttggaccg     2340

gtgccaccaa gtatcatctg aatggcagag actctctggt aaatcccggt gtcgctatgg     2400

caacgcacaa ggacgacgaa gagcgatttt ttccatccag cggagtcttg atgtttggga     2460

aacagggagc tggaaaagac aacgtggact atagcagcgt tatgctaacc agtgaggaag     2520

aaatcaaaac caccaaccca gtggccacag aacagtacgg cgtggtggcc gataacctgc     2580

aacagcaaaa cgccgctcct attgtagggg ccgtcaacag tcaaggagcc ttacctggca     2640

tggcctggca gaaccgggac gtgtacctgc agggtcctat ctgggccaag attcctcaca     2700

cggacggcaa ctttcatcct tcgccgctga tgggaggctt tggactgaaa cacccgcctc     2760

ctcagatcct gattaagaat acacctgttc ccgcggatcc tccaactacc ttcagtcaag     2820

ccaagctggc gtcgttcatc acgcagtaca gcaccggaca ggtcagcgtg gaaattgaat     2880

gggagctgca gaaagagaac agcaagcgct ggaacccaga gattcagtat acttccaact     2940

actacaaatc tacaaatgtg gactttgctg tcaatactga gggtacttat tcagagcctc     3000

gccccattgg cacccgttac ctcacccgta acctgtaatt gcctgttaat caataaaccg     3060

gttaattcgt ttcagttgaa ctttggtctc tgcgaagggc gaattc                    3106


<210> 4999
<211> 3197
<212> DNA
<213> Adeno-associated virus

<400> 4999
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttaca agaccggatg ttcaaatttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaagggag agccggtcaa cgaggcagac gccgcggccc tcgagcacga caaggcctac     1080

gacaagcagc tcgagcaggg ggacaacccg tacctcaagt acaaccacgc cgacgccgag     1140

tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca ccccagcgtt ctccagactc ctctacgggc     1320

atcggcaaga caggccagca gcccgcgaaa aagagactca actttgggca gactggcgac     1380

tcagagtcag tgcccgaccc tcaaccaatc ggagaacccc ccgcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctccccacct acaacaacca cctctacaag     1620

caaatctcca acgggacatc gggaggaagc accaacgaca acacctactt cggctacagc     1680

accccctggg ggtattttga ctttaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaacaa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtctt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tacctgactc tgaacaacgg cagtcaggcc gtgggccgtt cctccttcta ctgcctggag     2040

tactttcctt ctcaaatgct gagaacgggc aacaactttg agttcagcta ccagtttgag     2100

gacgtgcctt ttcacagcag ctacgcgcac agccaaagcc tggaccggct gatgaacccc     2160

ctcatcgacc agtacctgta ctacctgtct cggactcagt ccacgggagg taccgcagga     2220

actcagcagt tgctattttc tcaggccggg cctaataaca tgtcggctca ggccaaaaac     2280

tggctacccg ggccctgcta ccggcagcaa cgcgtctcca cgacactgtc gcaaaataac     2340

aacagcaact ttgcttggac cggtgccacc aagtatcatc tgaatggcag agactctctg     2400

gtaaatcccg gtgtcgctat ggcaacgcac aaggacgacg aagagcgatt ttttccatcc     2460

agcggagtct tgatgtttgg gaaacaggga gctggaaaag acaacgtgga ctatagcagc     2520

gttatgctaa ccagtgagga agaaatcaaa accaccaacc cagtggccac agaacagtac     2580

ggcgtggtgg ccgataacct gcaacagcaa aacgccgctc ctattgtagg ggccgtcaac     2640

agtcaaggag ccttacctgg catggtctgg cagaaccggg acgtgtacct gcagggtcct     2700

atctgggcca agattcctca cacggacggc aactttcatc cttcgccgct gatgggaggc     2760

tttggactga aacacccgcc tcctcagatc ctgattaaga atacacctgt tcccgcggat     2820

cctccaacta ccttcagtca agccaagctg gcgtcgttca tcacgcagta cagcaccgga     2880

caggtcagcg tggaaattga atgggagctg cagaaagaga acagcaagcg ctggaaccca     2940

gagattcagt atacttccaa ctactacaaa tctacaaatg tggactttgc tgtcaatact     3000

gagggtactt attcagagcc tcgccccatt ggcacccgtt acctcacccg taacctgtaa     3060

ttgcctgtta atcaataaac cggttaattc gtttcagttg aactttggtc tctgcgaagg     3120

gcgaattcgt ttaaacctgc aggactagtc cctttagtga gggttaattc tgagcttggc     3180

gtaatcatgg gtcatag                                                    3197


<210> 5000
<211> 3276
<212> DNA
<213> Adeno-associated virus

<400> 5000
gaattcgccc ttcgcagaga ccaaagttca actgaaacga attaaccggt ttattgatta       60

acaggcaatt acaggttacg ggtgaggtaa cgggtgccaa tggggcgagg ctcagtataa      120

accccttcgt tgttgacagc aaattccaca ttattagact tggcataatt tgaggtgtac      180

tgaatctctg gattccagcg tttgctgttt tctttctgca gttcccactc gatctccacg      240

ctgacctggc cggtgctgta ctgcgtgata aatgaggcaa acttggcagg agtaaacacc      300

tctggaggat tagcaggtac cggggtgttt ttgatgagaa tttgaggagg cgggtgtttg      360

agtccaaatc cgtccatcag gggagacggg tgaaagttgc cgtccgtgtg aggaattttg      420

gcccagatgg gaccctgcag gtacacgtcc cggttctgcc agaccatgcc gggcagagcc      480

ccctggctgt tgacagtctg tgtctggggt ccggccgtag acgattgcag gttgctggag      540

accacaccgt attcttctgt agccacggga ttggtggttt tgatctcctc ctcgctggtc      600

attagcacgt tttccagcgt tgtcttgttg gcagcccccg ttttgccaaa aaccagcact      660

ccgttgatgg gaaagaactg gtcctcgtcg tccttgttgg tggccatggc tacgcccggg      720

ttggttaatg aatttctacc attcagatgg tatttagtgg ccccggtcca ggcaaagtta      780

ctgttgttgt tgctgtctat gttttttgac agtctctgct gccgataaca gggtccgggc      840

agccagttct ttgattgctc ggccatggtg ttgggcccag cctgatggaa ctgcagctcc      900

cttgtggacc ccgtagtgct ctgggtccgg gccaggtagt acaggtactg gtcgatgagg      960

ggattcatca gccggtccag gctctggcta tgcgcatagc tgctgtggaa aggcacttcc     1020

tcaaaggtgt agctgaattc aaagttattg cccgttctca gcatctgaga aggaaagtac     1080

tccaggcagt agaaggagga acgtcccaca gactgactgc cgttgtttag agtcagatat     1140

ccgtactgag gaatcatgaa cacgtccgca gggaacggag ggaggcagcc ctggtgcgca     1200

gagccgagga cgtacggcag ttggtactcc gagtccgaga agacctgaat cgtgctggta     1260

aggttattag cgatggtcgt aacgccgtcg tccgtcgtga cctccttgac ctggatgttg     1320

aacaacttga accgcagctt tctgggccgg aatccccagt tgttgttgat gagtcgctgc     1380

cagtcacgtg gtgagaagtg gcagtggaat ctgttaaagt caaaataccc ccagggggtg     1440

ctgtagccga agtaggtgtt gtcgttggtg cttcctcccg atgtcccgtt ggagatttgc     1500

ttgtagaggt ggttgttgta ggtggggagg gcccaggttc gggtgctggt ggtgatgact     1560

ctgtcgccca gccatgtgga atcgcaatgc caatttcctg aggaactacc cactccgtcg     1620

gcgccttcgt tattgtctgc cattggagcg ccaccgcctg cagccattgt accagatccc     1680

agaccagagg ggcctgcggg gggttctccg attggttgag ggtcgggcac tgactctgag     1740

tcgccagtct gcccaaagtt gagtctcttt ttcgcgggct gctggcctgt cttgccgatg     1800

cccgtagagg agtctggaga acgctggggt gatggctcta ccggtctctt ctttccagga     1860

gccgtcttag cgccttcctc aaccagaccg agaggttcga gaacccgctt cttggcctgg     1920

aagactgctc gcccgaggtt gcccccaaaa gacgtatctt cttgaagacg ctcctgaaac     1980

tcggcgtcgg cgtggttgta cttgaggtac gggttgtccc cctgctcgag ctgcttgtcg     2040

taggccttgt cgtgctcgag ggccgcggcg tctgcctcgt tgaccggctc tcccttgtcg     2100

agtccgttga agggtccgag gtacttgtag ccaggaagca ccagaccccg gccgtcgtcc     2160

tgcttttgct ggttggcttt gggtttcggg gctccaggtt tcaagtccca ccactcgcga     2220

atgccctcag agaggttgtc ctcgagccaa tctggaagat aaccatcggc agccatacct     2280

ggtttaagtc atttattgct cagaaacaca gtcatccagg tccacgttga ccagatcgca     2340

ggccgagcaa gcaatctcgg gagcccgccc cagcagatga tgaatggcac agagtttccg     2400

atacgtcctc tttctgacga ccggttgaga ttctgacacg ccggggaaac attctgaaca     2460

gtctctggtc ccgtgcgtga agcaaatgtt gaaattctga ttcattctct cgcatgtctt     2520

gcagggaaac agcatctgaa gcatgcccgc gtgacgagaa cacttgtttt ggtacctgtc     2580

ggcaaagtcc accggagctc cttccgcgtc tgacgtcgat ggatgcaaaa tgtcgcaaaa     2640

gcactcacgt gacagctaat acaggaccac tcccctatga cgtgatttac gtcagcgcta     2700

tgcccgcgtg acgagaacat ttgttttggt acctgtcggc aaagtccacc ggagctcctt     2760

ccgcgtctga cgtcgatgga tccgcgactg aggggcaggc ccgcttgggc tcgcttttat     2820

ccgcgtcatc gggggcgggt ctcttgttgg ctccaccctt tctgacgtag aactcatgcg     2880

ccacctcggt cacgtgatcc tgcgcccagc ggaagaactc tttgacttcc tgctttgtca     2940

ccttgccaaa gtcatgctcc agacggcggg tgagttcaaa tttgaacatc cggtcctgca     3000

acggctgctg gtgctcgaag gtggtgctgt tcccgtcaat cacggcgcac atgttggtgt     3060

tggaagtgac gatcacgggg gtgggatcga tctgggcgga agacttgcac ttttggtcca     3120

cgcgcacctt gctgccgccg agaatggcct tggcggactc cacgaccttg gccgtcatct     3180

tgccctcctc ccaccagatc accatcttgt cgacgcaatc gttgaaggga aagttctcat     3240

tggtccagtt gacgcagccg tagaaagggc gaattc                               3276


<210> 5001
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5001
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Pro Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Gly Ala 
            580                 585                 590         


Pro Ile Val Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Val Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5002
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5002
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Pro Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Gly Ala 
            580                 585                 590         


Pro Ile Val Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5003
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5003
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5004
<211> 2489
<212> DNA
<213> Adeno-associated virus

<400> 5004
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtgaagt      120

ccgccaaggc cattcatcat ctgctggggc gggctcccga gattgcttgc tcggcctgcg      180

atctggtcaa cgtggacctg gatgactgtg tttctgagca ataaatgact taaaccaggt      240

atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc      300

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      360

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      420

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      480

aagcagctcg agcaggggga caacccgtac ctcaagtaca accacgccga cgccgagttt      540

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      600

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      660

ggaaagaaga gacccataga atcccccgac tcctccacgg gcatcggcag gaaaggccag      720

cagcccgcta aaaagaagct caactttggg cagactggcg actcagagtc agtgcccgac      780

cctcaaccaa tcggagaacc ccccgcaggc ccctctggtc tgggatctgg tacaatggct      840

gcaggcggtg gcgctccaat ggcagacaat aacgaaggcg ccgacggagt gggtaatgcc      900

tccggaaatt ggcattgcga ttccacatgg ctgggcgaca gagtcatcac caccagcacc      960

cgcacctggg ccctgcccac ctacaacaac cacctctaca agcagatatc aagtcagagc     1020

ggggctacca acgacaacca cttcttcggc tacagcaccc cctggggcta ttttgacttc     1080

aacagattcc actgccactt ctcaccacgt gactggcagc gactcatcaa caacaactgg     1140

ggattccggc ccagaaagct gcggttcaag ttgttcaaca tccaggtcaa ggaggtcacg     1200

acgaacgacg gcgttacgac catcgccaat aaccttacca gcacgattca ggtcttctcg     1260

gactcggagt accaactgcc gtacgtcctc ggctctgcgc accagggctg cctccctccg     1320

ttccctgcgg acgtgttcat gattcctcag tacggatatc tgactctaaa caacggcagt     1380

cagtctgtgg gacgttcctc cttctactgc ctggagtact ttccttctca gatgctgaga     1440

acgggcaata actttgaatt cagctacacc tttgaggaag tgcctttcca cagcagctat     1500

gcgcacagcc agagcctgga ccggctgatg aatcccctca tcgaccagta cctgtactac     1560

ctggcccgga cccagagcac tacggggtcc acaagggagc tgcagttcca tcaggctggg     1620

cccaacacca tggccgagca atcaaagaac tggctgcccg gaccctgtta tcggcagcag     1680

agactgtcaa aaaacataga cagcaacaac aacagtaact ttgcctggac cggggccact     1740

aaataccatc tgaatggtag aaattcatta accaacccgg gcgtagccat ggccaccaac     1800

aaggacgacg aggaccagtt ctttcccatc aacggagtgc tggtttttgg caaaacgggg     1860

gctgccaaca agacaacgct ggaaaacgtg ctaatgacca gcgaggagga gatcaaaacc     1920

accaatcccg tggctacaga agaatacggt gtggtctcca gcaacctgca atcgtctacg     1980

gccggacccc agacacagac tgtcaacagc cagggggctc tgcccggcat ggtctggcag     2040

aaccgggacg tgtacctgca gggtcccatc tgggccaaaa ttcctcacac ggacggcaac     2100

tttcacccgt ctcccctgat gggcggattt ggactcaaac acccgcctcc tcaaattctc     2160

atcaaaaaca ccccggtacc tgctaatcct ccagaggtgt ttactcctgc caagtttgcc     2220

tcatttatca cgcagtacag caccggccag gtcagcgtgg agatcgagtg ggaactgcag     2280

aaagaaaaca gcaaacgctg gaatccagag attcagtaca cctcaaatta tgccaagtct     2340

aataatgtgg aatttgctgt caacaacgaa ggggtttata ctgagcctcg ccccattggc     2400

acccgttacc tcacccgtaa cctgtaattg cctgttaatc aataaaccgg ttaattcgtt     2460

tcagttgaac tttggtcaag ggcgaattc                                       2489


<210> 5005
<211> 3098
<212> DNA
<213> Adeno-associated virus

<400> 5005
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcttccg      180

cccagatcga tcccaccccc gtgatcgtca cttccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttaca agaccggatg ttcaaatttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accggagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaagggag agccggtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagacccat agaatccccc gactcctcca cgggcatcgg caagaaaggc     1320

cagcagcccg ctaaaaagaa gctcaacttt gggcagactg gcgactcaga gtcagtgccc     1380

gaccctcaac caatcggaga accccccgca ggcccctctg gtctgggatc tggtacaatg     1440

gctgcaggcg gtggcgctcc aatggcagac aataacgaag gcgccgacgg agtgggtaat     1500

gcctccggaa attggcattg cgattccaca tggctgggcg acagagtcat caccaccagc     1560

acccgcacct gggccctgcc cacctacaac aaccacctct acaagcagat atcaagtcag     1620

agcggggcta ccaacgacaa ccacttcttc ggctacagca ccccctgggg ctattttgac     1680

ttcaacagat tccactgcca cttctcacca cgtgactggc agcgactcat caacaacaac     1740

tggggattcc ggcccagaaa gctgcggttc aagttgttca acatccaggt caaggaggtc     1800

acgacgaacg acggcgttac gaccatcgct aataacctta ccagcacgat tcaggtcttc     1860

tcggactcgg agtaccaact gccgtacgtc ctcggctctg cgcaccaggg ctgcctccct     1920

ccgttccctg cggacgtgtt catgattcct cagtacggat atctgactct aaacaacggc     1980

agtcagtctg tgggacgttc ctccttctac tgcctggagt actttccttc tcagatgctg     2040

agaacgggca ataactttga attcagctac acctttgagg aagtgccttt ccacagcagc     2100

tatgcgcaca gccagagcct ggaccggctg atgaatcccc tcatcgacca gtacctgtac     2160

tacctggccc ggacccagag cactacgggg tccacaaggg agctgcagtt ccatcaggct     2220

gggcccaaca ccatggccga gcaatcaaag aactggctgc ccggaccctg ttatcggcgg     2280

cagagactgt caaaagacat agacagcaac aacaacagta actttgcctg gaccggggcc     2340

actaaatacc atctgaatgg tagaaattca ttaaccaacc cgggcgtagc catggccacc     2400

aacaaggacg acgaggacca gttctttccc atcaacggag tgctggtttt tggcaaaacg     2460

ggggctgcca acaagacaac gctggaaaac gtgctaatga ccagcgagga ggagatcaaa     2520

accaccaatc ccgtggctac agaagaatac ggtgtggtct ccagcaacct gcaatcgtct     2580

acggccggac cccagacaca gactgtcaac agccaggggg ctctgcccgg catggtctgg     2640

cagaaccggg acgtgtacct gcagggtccc atctgggcca aaattcctca cacggacggc     2700

aactttcacc cgtctcccct gatgggcgga tttggactca aacacccgcc tcctcaaatt     2760

ctcatcaaaa acaccccggt acctgctaat cctccagagg tgtttactcc tgccaagttt     2820

gcctcattta tcacgcagta cagcaccggc caggtcagcg tggagatcga gtgggaactg     2880

cagaaagaga acagcaaacg ctggaatcca gagattcagt acacctcaaa ttatgccaag     2940

tctaataatg tggaatttgc tgtcaacaac gaaggggttt atactgagcc tcgccccatt     3000

ggcacccgtt acctcacccg taacctgtaa ttacttgtta atcaataaac cggttgattc     3060

gtttcagttg aactttggtc tctgcgaagg gcgaattc                             3098


<210> 5006
<211> 2969
<212> DNA
<213> Adeno-associated virus

<400> 5006
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttaca agaccggatg ttcaaatttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatc      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaagggag agccggtcaa cgaggcagac gccgcggccc tcgagcacga caaggcctac     1080

gacaagcagc tcgagcaggg ggacaacccg tacctcaagt acaaccacgc cgacgccgag     1140

tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca ccccagcgtt ctccagactc ctctacgggc     1320

atcggcaaga caggccagca gcccgcgaaa aagagactca actttgggca gactggcgac     1380

tcagagtcag tgcccgaccc tcaaccaatc ggagaacccc ccgcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctccccacct acaacaacca cctctacaag     1620

caaatctcca acgggacatc gggaggaagc accaacgaca acacctactt cggctacagc     1680

accccctggg ggtattttga ctttaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaacaa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtctt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tacctgactc tgaacaacgg cagtcaggcc gtgggccgtt cctccttcta ctgcctggag     2040

tactttcctt ctcaaatgct gagaacgggc aacaactttg agttcagcta ccagtttgag     2100

gacgtgcctt ttcacagcag ctacgcgcac agccaaagcc tggaccggct gacgaacccc     2160

ctcatcgacc agtacctgta ctacctggcc cggacccaga gcactacggg gtccacaagg     2220

gggctgcagt tccatcaggc tgggcccaac accatggccg agcaatcaaa gaactggctg     2280

cccggaccct gttatcggca gcagagactg tcaaaaaaca tagacagcaa caacaacagt     2340

aactttgcct ggaccggggc cactaaatac catctgaatg gtagaaattc attaaccaac     2400

ccgggcgtag ccatggccac caacaaggac gacgaggacc agttctttcc catcaacgga     2460

gtgctggttt ttggcaaaac gggggctgcc aacaagacaa cgctggaaaa cgtgctaatg     2520

accagcgagg aggagatcaa aaccaccaat cccgtggcta cagaagaata cggtgtggtc     2580

tccagcaacc tgcaatcgtc tacggccgga ccccagacac agactgtcaa cagccagggg     2640

gctctgcccg gcatggtctg gcagaaccgg gacgtgtacc tgcagggtcc catctgggcc     2700

aaaattcctc acacggacgg caactttcac ccgtctcccc tgatgggcgg atttggactc     2760

aaacacccgc ctcctcaaat tctcatcaag tatacttcca actactacaa atctacaaat     2820

gtggactttg ctgtcaatac tgagggtact tattcagagc ctcgccccat tggcacccgt     2880

tacctcaccc gtaacctgta attgcctgtt aatcaataaa ccggttaatt cgtttcagtt     2940

gaactttggt ctctgcgaag ggcgaattc                                       2969


<210> 5007
<211> 3113
<212> DNA
<213> Adeno-associated virus

<400> 5007
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga tcccaccccc gtgatcgtca cttccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttaca agaccggatg ttcaaatttg      300

aactcacccg ccgtctggag catgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagacccat agaatccccc gactcctcca cgggcatcgg caagaaaggc     1320

cagcagcccg ctaaaaagaa gctcaacttt gggcagactg gcgactcaga gtcagtgccc     1380

gaccctcaac caatcggaga accccccgca ggcccctctg gtctgggatc tggtacaatg     1440

gctgcaggcg gtggcgctcc aatggcagac aataacgaag gcgccgacgg agtgggtagt     1500

tcctcaggaa attggcattg cgattccaca tggctgggcg acagagtcat caccaccagc     1560

acccgaacct gggccctccc cacctacaac aaccacctct acaagcaaat ctccaacggg     1620

acatcgggag gaagcaccaa cgacaacacc tacttcggct acagcacccc ctgggggtat     1680

tttgacttta acagattcca ctgccacttc tcaccacgtg actggcagcg actcatcaac     1740

aacaactggg gattccggcc caagagactc aacttcaagc tcttcaacat ccaggtcaag     1800

gaggtcacgc agaatgaagg caccaagacc atcgccaata accttaccag cacgattcag     1860

gtctttacgg actcggaata ccagctcccg tacgtcctcg gctctgcgca ccagggctgc     1920

ctgcctccgt tcccggcgga cgtcttcatg attcctcagt acgggtacct gactctgaac     1980

aacggcagtc aggccgtggg ccgttcctcc ttctactgcc tggagtactt tccttctcaa     2040

atgctgagaa cgggcaacaa ctttgagttc agctaccagt ttgaggacgt gccttttcac     2100

agcagctatg cgcacagcca aagcctggac cggctgatga accccctcat cgaccagtac     2160

ctgtactacc tgtctcggac tcagtccacg ggaggtaccg caggaactca gcagttgcta     2220

ttttctcagg ccgggcctaa taacatgtcg gctcaggcca aaaactggct acccgggccc     2280

tgctaccggc agcaacgcgt ctccacgaca gtgtcgcaaa ataacaacag caactttgct     2340

tggaccggtg ccaccaagta tcatctgaat ggcagagact ctctggtaaa tcccggtgtc     2400

gctatggcaa cgcacaaggg cgacgaagag cgattttttc catccagcgg agtcttgatg     2460

tttgggaaac agggagctgg aaaagacaac gtggactata gcagcgttat gctaaccagt     2520

gaggaagaaa tcaaaaccac caacccagtg gccacagaac agtacggcgt ggtggccgat     2580

aacctgcaac agcaaaacgc cgctcctatt gtaggggccg tcaacagtca aggagcctta     2640

cctggcatgg tctggcagaa ccgggacgtg tacctgcagg gtcctatctg ggccaagatt     2700

cctcacacgg acggcaactt tcatccttcg ccgctgatgg gaggctttgg actgaaacac     2760

ccgcctcctc agatcctgat taagaataca cctgttcccg cggatcctcc aactaccttc     2820

agtcaagcca agctggcgtc gttcatcacg cagtacagca ccggacaggt cagcgtggaa     2880

attgaatggg agctgcagaa agagaacagc aagcgctgga acccagagat tcagtatact     2940

tccaactact acaaatctac aaatgtggac tttgctgtca atactgaggg tacttattca     3000

gagcctcgcc ccattggcac ccgttacctc acccgtagcc tgtaattgcc tgttaatcaa     3060

taaaccggtt gattcgtttc agttgaactt tggtctctgc gaagggcgaa ttc            3113


<210> 5008
<211> 3128
<212> DNA
<213> Adeno-associated virus

<400> 5008
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgca ggaccggatg ttcaaatttg      300

aactcacccg ccgtctggag catgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcgcggg accagagact      660

gttcagaatg tttcccgggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca ccccagcgtt ctccagactc ctctacgggc     1320

atcggcaaga caggccagca gcccgcgaaa aagagactca actttgggca gactggcgac     1380

tcagagtcag tgcccgaccc tcaaccaatc ggagaacccc ccgcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctccccacct acaacaacca cctctacaag     1620

caaatctcca acgggacatc gggaggaagc accaacgaca acacctactt cggctacagc     1680

accccctggg ggtattttga ctttaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaacaa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtctt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcccgcc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tacctgactc tgaacaacgg cagtcaggcc gtgggccgtt cctccttcta ctgcctggag     2040

tactttcctt ctcaaatgcg gagaacgggc aacaactttg agttcagcta ccagtttgag     2100

gacgtgcctt ttcacagcag ctacgcgcat agccaaagcc tggaccggct gatgaacccc     2160

ctcatcgacc agtacctgta ctacctgtct cggactcagt ccacgggagg taccgcagga     2220

actcagcagt tgctattttc tcaggccggg cctaataaca tgtcggctca ggccaaaaac     2280

tggctacccg ggccctgcta ccggcagcaa cgcgtctcca cgacactgtc gcaaaataac     2340

aacagcaact ttgcttggac cggtgccacc aagtatcatc tgaatggcag agactctctg     2400

gtaaatcccg gtgtcgctat ggcaacgcac aaggacgacg aagagcgatt ttttccatcc     2460

agcggagtct tgatgtttgg gaaacaggga gctggaaaag acaacgtgga ctatagcagc     2520

gttatgctaa ccagtgagga agaaatcaaa accaccaacc cagtggccac agaacagtac     2580

ggcgtggtgg ccgataacct gcaacagcaa aacgccgctc ctattgtagg ggccgtcaac     2640

agtcaaggag ccttacctgg catggtctgg cagaaccggg acgtgtacct gcagggtcct     2700

atctgggcca agattcctca cacggacggc aactttcatc cttcgccgct gatgggaggc     2760

tttggactga aacacccgcc tcctcagatc ctgattaaga atacacctgt tcccgcggat     2820

cctccaacta ccttcagtca agccaagctg gcgtcgttca tcacgcagta cagcaccgga     2880

caggtcagcg tggaaattga atgggagctg cagaaagaga acagcaagcg ctggaaccca     2940

gagattcagt atacttccaa ctactacaaa tctacaaatg tggactttgc tgtcaatact     3000

gagggtactt attcagagcc tcgccccatt ggcacccgtt acctcacccg taacctgtaa     3060

ttgcctgtta atcaataaac cggttaattc gtttcagttg aactttggtc tctgcgaagg     3120

gcgaattc                                                              3128


<210> 5009
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5009
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Pro Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Gly Ala 
            580                 585                 590         


Pro Ile Val Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5010
<211> 1933
<212> DNA
<213> Adeno-associated virus


<220>
<221> modified_base
<222> (1302)..(1302)
<223> a, c, t or g

<400> 5010
caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc       60

cgacgccgag tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg      120

agcagtcttc caggccaaaa agcgggttct cgaacctctt ggtctggttg agacgccagc      180

taagacggca cctggaaaga agcgaccggt agactcgcca gactccacct cgggcatcgg      240

caagaaaggc cagcagcccg cgaaaaagag actcaacttt gggcagactg gcgactcaga      300

gtcagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc      360

tggtacaatg gctgcaggcg gtggcgcacc aatggctgac aataacgagg gcgccgacgg      420

agtgggtaat gcctcaggaa attggcattg cgattccaca tggctgggcg acagagtcat      480

caccaccagc acccgaacct gggccctgcc cacctacaac aaccacctct acaagcaaat      540

ctccagtcag tcagcaggga gcaccaacga taacgtctat ttcggctaca gcaccccctg      600

ggggtatttt gacttcaaca gattccattg ccacttctca ccacgtgact ggcagcgact      660

tatcaacaac aactggggat tccggcccaa gaagctcaac ttcaagctct tcaacatcca      720

ggtcaaggag gtcacgacga atgacggtgt cacaaccatc gctaataacc ttaccagcac      780

ggttcaggtc ttttcggact cggaatatca actgccgtac gtcctcggct ccgcgcacca      840

gggctgcctg cctccgttcc cggcagacgt gttcatgatt ccgcagtacg gatacctgac      900

tctgaacaat ggcagccaat cggtaggccg ttcctccttc tactgcctgg agtactttcc      960

ttctcagatg ctgagaacgg gcaacaactt cacctttagc tacaccttcg aggacgtgcc     1020

tttccacagc agctacgcgc acagccagag tctggaccgg ctgatgaatc ccctcatcga     1080

ccagtacctg tactacttgg ccagaacaca gagcaacgca ggaggtactg ctggcaatcg     1140

ggaactgcag ttttatcagg gcggacctac caccatggcc gaacaagcaa agaactggct     1200

gcccggacct tgcttccggc aacagagagt atccaagacg ctggatcaaa ataacaacag     1260

caactttgcc tggactggtg ccacaaaata ccatttaaat gnaagaaatt cattggttaa     1320

tcccggtgtc gccatggcaa cccacaagga cgacgaggaa cgcttcttcc cttcgagcgg     1380

agttctaatt tttggcaaaa ctggagcagc taataaaact acattagaaa acgtgctcat     1440

gacaaatgaa gaagaaattc gtcctaccaa cccggtagct accgaggaat acgggattgt     1500

aagcagcaac ttgcaggcgg ctagcaccgc agcccagaca caagttgtta acaaccaggg     1560

agccttacct ggcatggtct ggcagaaccg ggacgtgtac ctgcaaggtc ccatttgggc     1620

caagattcct cacacggacg gcaactttca cccgtctcct ctaatgggtg gctttggact     1680

gaaacacccg cctccccaga tcctgatcaa aaacacaccg gtacctgcta atcctccaga     1740

agtgtttact cctgccaagt ttgcttcctt catcacgcag tacagcaccg ggcaagtcag     1800

cgttgagatc gagtgggagc tgcagaaaga gaacagcaag cgctggaacc cagagattca     1860

gtacacctcc aactttgaca aacagactgg agtggacttt gctgttgaca gccagggtgt     1920

ttactctgag cct                                                        1933


<210> 5011
<211> 3105
<212> DNA
<213> Adeno-associated virus

<400> 5011
gaattcgccc ttgctgcgtc aactggacca atgagaactt tcccttcaac gattgcgtcg       60

acaagatggt gatctggtgg gaggagggca agatgaccgc caaggtcgtg gagtccgcca      120

aggccattct gggcggaagc aaggtgcgcg tggaccaaaa gtgcaagtca tcggcccaga      180

tcgaccccac gcccgtgatc gtcacctcca acaccaacat gtgcgccgtg atcgacggga      240

acagcaccac cttcgagcac cagcagccgc tgcaggaccg catgttcaag ttcgagctca      300

cccgccgtct ggagcacgac tttggcaagg tgaccaagca ggaagtcaaa gagttcttcc      360

gctgggctca ggatcacgtg actgaggtgg cgcatgagtt ctacgtcaga aagggcggag      420

ccaccaaaag acccgccccc agtgacgcgg atataagcga gcccaagcgg gcctgcccct      480

cagttgcgga gccatcgacg tcagacgcgg aagcaccggt ggactttgcg gacaggtacc      540

aaaacaaatg ttctcgtcac gcgggcatgc ttcagatgct gtttccctgc aagacatgcg      600

agagaatgaa tcagaatttc aacgtctgct tcacgcacgg ggtcagagac tgctcagagt      660

gcttccccgg cgcgtcagaa tctcaacccg tcgtcagaaa aaagacgtat cagaaactgt      720

gcgcgattca tcatctgctg gggcgggcac ccgagattgc gtgttcggcc cgcgatctcg      780

tcaacgtgga cttggatgac tgtgtttctg agcaataaat gacttaaacc aggtatggct      840

gctgacggtt atcttccaga ttggctcgag gacaacctct ctgagggcat tcgcgagtgg      900

tgggacctga aacctggagc ccccaagccc aaggccaacc agcagaagca ggacgacggc      960

cggggtctgg tgcttcctgg ctacaagtac ctcggaccct tcaacggact cgacaagggg     1020

gagcccgtca acgcggcgga cgcagcggcc ctcgagcacg acaaggccta cgaccagcag     1080

ctcaaagcgg gtgacaatcc gtacctgcgg tataaccacg ccgacgccga gtttcaggag     1140

cgtctgcaag aagatacgtc ttttgggggc aacctcgggc gagcagtctt ccaggccaag     1200

aagagggtac tcgaacctct gggcctggtt gaagaaggtg ctaagacggc tcctggaaag     1260

aagagaccgt tagagtcacc acaagagccc gactcctcct caggaatcgg caaaaaaggc     1320

aaacaaccag ccaaaaagag actcaacttt gaagaggaca ctggagccgg agacggaccc     1380

cctgaaggat cagataccag cgccatgtct tcagacattg aaatgcgtgc agcaccgggc     1440

ggaaatgctg tcgatgcggg acaaggttcc gatggagtgg gtaatgcctc gggtgattgg     1500

cattgcgatt ccacctggtc tgagggcaag gtcacaacaa cctcgaccag aacctgggtc     1560

ttgcccacct acaacaacca cttgtacctg cggctcggaa caacatcaaa cagcaacacc     1620

tacaacggat tctccacccc ctggggatac tttgacttta acagattcca ctgtcacttc     1680

tcaccacgtg actggcaaag actcatcaac aacaactggg gactacgacc aaaagccatg     1740

cgcgttaaaa tcttcaatat ccaagttaag gaggtcacaa cgtcgaacgg cgagactacg     1800

gtcgctaata accttaccag cacggttcag atatttgcgg actcgtcgta tgagctcccg     1860

tacgtgatgg acgctggaca agagggaagt ctgtctcctt tccccaatga cgtcttcatg     1920

gtgcctcaat atggctactg tggcattgtg actggcgaaa atcagaacca gacggacaga     1980

aatgctttct actgcctgga gtattttcct tcacaaatgc tgagaactgg caataacttt     2040

gaaatggctt acaactttgg gaaggtgccg ttccactcaa tgtatgctta cagccagagc     2100

ccggacagac tgatgaatcc cctcctggac cagtacctgt ggcacttaca gtcgaccacc     2160

tctggagaga ctctgaatca aggcaatgca gcaaccacat ttggaaaaat caggagtgga     2220

gactttgcct tttacagaaa gaactggctg cctgggcctt gtgttaaaca gcagagactc     2280

tcaaaaactg ccagtcaaaa ttacaagatt cctgccagcg ggggcaacgc tctgttaaag     2340

tatgacaccc actatacctt aaacaaccgc tggagcaaca tagcgcctgg acctccaatg     2400

gcaacagctg gaccttcaga tggggacttc agcaacgccc agctcatctt ccctggacca     2460

tcagtcaccg gaaacacaac aacctcagca aacaatctgt tgtttacatc agaagaagaa     2520

attgctgcca ccaacccaag agacacggac atgtttggtc agattgctga caataatcag     2580

aatgctacaa ctgctcccat aaccggcaac gtgactgcta tgggagtgct tcctggcatg     2640

gtgtggcaaa acagagacat ttactaccaa gggccaattt gggccaagat cccacacgcg     2700

gacggacatt ttcatccttc accgctaatt ggcggttttg gactgaaaca tccgcctccc     2760

cagatattta tcaaaaacac ccccgtacct gccaatcctg cgacaacctt cactgcagcc     2820

agagtggact ctttcatcac acaatacagc accggccagg tcgctgttca gattgaatgg     2880

gaaatcgaaa aggaacgctc caaacgctgg aatcctgaag tgcagtttac ttcaaactat     2940

gggaaccagt cttctatgtt gtgggctccc gatacaactg ggaagtatac agagccgcgg     3000

gttattggct ctcgttattt gactaatcat ttgtaactgc ctagttaatc aataaaccgt     3060

gtgattcgtt tcagttgaac tttggtctct gcgaagggcg aattc                     3105


<210> 5012
<211> 733
<212> PRT
<213> Adeno-associated virus

<400> 5012
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Arg Leu Asn Phe Glu Glu Asp Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Asp Thr Ser Ala Met Ser 
            180                 185                 190         


Ser Asp Ile Glu Met Arg Ala Ala Pro Gly Gly Asn Ala Val Asp Ala 
        195                 200                 205             


Gly Gln Gly Ser Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly Lys Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu Gly Thr 
                245                 250                 255     


Thr Ser Asn Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Leu Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Ile Val Thr Gly Glu Asn Gln Asn Gln Thr Asp Arg Asn Ala 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Met Ala Tyr Asn Phe Glu Lys Val Pro Phe His Ser Met 
                405                 410                 415     


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Leu Asp 
            420                 425                 430         


Gln Tyr Leu Trp His Leu Gln Ser Thr Thr Ser Gly Glu Thr Leu Asn 
        435                 440                 445             


Gln Gly Asn Ala Ala Thr Thr Phe Gly Lys Ile Arg Ser Gly Asp Phe 
    450                 455                 460                 


Ala Phe Tyr Arg Lys Asn Trp Leu Pro Gly Pro Cys Val Lys Gln Gln 
465                 470                 475                 480 


Arg Phe Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro Ala Ser Gly 
                485                 490                 495     


Gly Asn Ala Leu Leu Lys Tyr Asp Thr His Tyr Thr Leu Asn Asn Arg 
            500                 505                 510         


Trp Ser Asn Ile Ala Pro Gly Pro Pro Met Ala Thr Ala Gly Pro Ser 
        515                 520                 525             


Asp Gly Asp Phe Ser Asn Ala Gln Leu Ile Phe Pro Gly Pro Ser Val 
    530                 535                 540                 


Thr Gly Asn Thr Thr Thr Ser Ala Asn Asn Leu Leu Phe Thr Ser Glu 
545                 550                 555                 560 


Glu Glu Ile Ala Ala Thr Asn Pro Arg Asp Thr Asp Met Phe Gly Gln 
                565                 570                 575     


Ile Ala Asp Asn Asn Gln Asn Ala Thr Thr Ala Pro Ile Thr Gly Asn 
            580                 585                 590         


Val Thr Ala Met Gly Val Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Ala Asp Gly 
    610                 615                 620                 


His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ala 
                645                 650                 655     


Thr Thr Phe Thr Ala Ala Arg Val Asp Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ala Val Gln Ile Glu Trp Glu Ile Glu Lys Glu Arg 
        675                 680                 685             


Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly Asn 
    690                 695                 700                 


Gln Ser Ser Met Leu Trp Ala Pro Asp Thr Thr Gly Lys Tyr Thr Glu 
705                 710                 715                 720 


Pro Arg Val Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730             


<210> 5013
<211> 3105
<212> DNA
<213> Adeno-associated virus

<400> 5013
gaattcgccc ttgctgcgtc aactggacca atgagaactt tcccttcaac gattgcgtcg       60

acaagatggt gatctggtgg gaggagggca agatgaccgc caaggtcgtg gagtccgcca      120

aggccattct gggcggaagc aaggtgcgcg tggaccaaaa gtgcaagtca tcggcccaga      180

tcgaccccac gcccgtgatc gtcacctcca acaccaacat gtgcgccgtg atcgacggga      240

acagcaccac cttcgagcac cagcagccgc tgcaggaccg catgttcaag ttcgagctca      300

cccgccgtct ggagcacgac tttggcaagg tgaccaagca ggaagtcaaa gagttcttcc      360

gctgggctca ggatcacgtg actgaggtgg cgcatgagtt ctacgtcaga aagggcggag      420

ccaccaaaag acccgccccc agtgacgcgg atataagcga gcccaagcgg gcctgcccct      480

cagttgcgga gccatcgacg tcagacgcgg aagcaccggt ggactttgcg gacaggtacc      540

aaaacaaatg ttctcgtcac gcgggcatgc ttcagatgct gtttccctgc aagacatgcg      600

agagaatgaa tcagaatttc aacgtctgct tcacgcacgg ggtcagagac tgctcagagt      660

gcttccccgg cgcgtcagaa tctcaacccg tcgtcagaaa aaagacgtat cagaaactgt      720

gcgcgattca tcatctgctg gggcgggcac ccgagattgc gtgttcggcc tgcgatctcg      780

tcaacgtgga cttggatgac tgtgtttctg agcaataaat gacttaaacc aggtatggct      840

gctgacggtt atcttccaga ttggctcgag gacaacctct ctgagggcat tcgcgagtgg      900

tgggacctga aacctggagc ccccaagctc aaggccaacc agcagaagca ggacgacggc      960

cggggtctgg tgcttcctgg ctacaagtac ctcggaccct tccacggact cgacaagggg     1020

gagcccgtca acgcggcgga cgcagcggcc ctcgagcacg acaaggccta cgaccagcag     1080

ctcaaagcgg gtgacaatcc gtacctgcgg tataaccacg ccgacgccga gtttcaggag     1140

cgtctgcaag aagatacgtc ttttgggggc aacctcgggc gagcagtctt ccaggccaag     1200

aagagggtac tcgaaccact gggcctggtt gaagaaggtg ctaagacggc tcctggaaag     1260

aagagaccgt tagagtcacc acaagagccc gactcctcct caggaatcgg caaaaaaggc     1320

aaacaaccag ccaaaaagag actcaacttt gaagaggaca ctggagccgg agacggaccc     1380

cctgaaggat cagataccag cgccatgtct tcagacattg aaatgcgtgc agcaccgggc     1440

ggaaatgctg tcgatgcggg acaaggttcc gatggagtgg gtaatgcctc gggtgattgg     1500

cattgcgatt ccacctggtc tgagggcaag gtcacaacaa cctcgaccag aacctgggtc     1560

ttgcccacct acaacaacca cttgtacctg cggctcggaa caacatcaaa cagcaacacc     1620

tacaacggat tctccacccc ctggggatac tttgacttta acagattcca ctgtcacttc     1680

tcaccacgtg actggcaaag actcatcaac aacaactggg gactacgacc aaaagccatg     1740

cgcgttaaaa tcttcaatat ccaagttaag gaggtcacaa cgtcgaacgg cgagactacg     1800

gtcgctaata accttaccag cacggttcag atatttgcgg actcgtcgta tgagctcccg     1860

tacgtgatgg acgctggaca agagggaagt ctgcctcctt tccccaatga cgtcttcatg     1920

gtgcctcaat atggctactg tggcattgtg actggcgaaa atcagaacca gacggacaga     1980

aatgctttct actgcctgga gtattttcct tcacaaatgc tgagaactgg caataacttt     2040

gaaatggctt acaactttga gaaggtgccg ttccactcaa tgtatgctca cagccagagc     2100

ctggacagac tgatgaatcc cctcctggac cagtacctgt ggcacttaca gtcgaccacc     2160

tctggagaga ctctgaatca aggcaatgca gcaaccacat ttggaaaaat caggagtgga     2220

gactttgcct tttacagaaa gaactggctg cctgggcctt gtgttaaaca gcagagattc     2280

tcaaaaactg ccagtcaaaa ttacaagatt cctgccagcg ggggcaacgc tctgttaaag     2340

tatgacaccc actatacctt aaacaaccgc tggagcaaca tagcgcctgg acctccaatg     2400

gcaacagctg gaccttcaga tggggacttc agcaacgccc agctcatctt ccctggacca     2460

tcagtcaccg gaaacacaac aacctcagca aacaatctgt tgtttacatc agaaggagaa     2520

attgctgcca ccaacccaag agacacggac atgtttggtc agattgctga caataatcag     2580

aatgctacaa ctgctcccat aaccggcaac gtgactgcta tgggagtgct tcctggcatg     2640

gtgtggcaaa acagagacat ttactaccaa gggccaattt gggccaagat cccacacgcg     2700

gacggacatt ttcatccttc accgctaatt ggcggttttg gactgaaaca tccgcctccc     2760

cagatattta tcaaaaacac ccccgtacct gccaatcctg cgacaacctt cactgcagcc     2820

agagtggact ctttcatcac acaatacagc accggccagg tcgctgttca gattgaatgg     2880

gaaatcgaaa aggaacgctc caaacgccgg aatcctgaag tgcagtttac ttcaaactat     2940

gggaaccagt cttctatgtt gtgggctccc gatacaactg ggaagtatac agagccgcgg     3000

gttattggct ctcgttattt gactaatcat ttgtaactgc ctagttaatc aataaaccgt     3060

gtgattcgtt tcagttgaac tttggtctct gcgaagggcg aattc                     3105


<210> 5014
<211> 3105
<212> DNA
<213> Adeno-associated virus

<400> 5014
gaattcgccc ttcgcagaga ccaaagttca actgaaacga atcacacggt ttattgatta       60

actaggcagt tacaaatgat tagtcaaata acgagagcca ataacccgcg gctctgtata      120

cttcccagtt gtatcgggag cccacaacat agaagactgg ttcccacagt ttgaagtaaa      180

ctgcacttca ggattccagc gtttggagcg ttccttttcg atttcccatt caatctgaac      240

agcgacctgg ccggtgctgt attgtgtgat gaaagagtcc actctggctg cagtgaaggt      300

tgtcgcagga taggcaggta cgggggtgtt tttgataaat atctggggag gcggatgttt      360

cagtccaaaa ccgccaatta gcggtgaagg atgaaaatgt ccgtccgcgt gtgggatctt      420

ggcccaaatt ggcccttggt agtaaatgtc tctgttttgc cacaccatgc caggaagcac      480

tcccatagca gtcacgttgc cggttatggg agcagttgta gcattctgat tattgtcagc      540

aatctgacca aacatgtccg tgtctcttgg gttggtggca gcaatttctt cttctgatgt      600

aaacaacaga ttgtttgctg aggttgttgt gtttccggtg actgatggtc cagggaagat      660

gagctgggcg ttgctgaagt ccccatctga aggtccagct gttgccattg gaggtccagg      720

cgctatgttg ctccagcggt tgtttaaggt atagtgggtg tcatacttta acagagcgtt      780

gcccccgctg gcaggaatct tgtaattttg actggcagtt tttgagaatc tctgctgttt      840

aacacaaggc ccaggcagcc agttctttct gtaaaaggca aagtctccac tcctgatttt      900

tccaaatgtg gttgctgcat tgccttgatt cagagtctct ccagaggtgg tcgactgtaa      960

gtgccacagg tactggtcca ggaggggatt catcagtccg tccaggctct ggctgtgagc     1020

atacattgag tggaacggca ccttctcaaa gttgtaagcc gtttcaaagt tattgccagt     1080

tctcagcatt tgtgaaggaa aatactccag gcagtagaaa gcatttctgt ccgtctggtt     1140

ctgattttcg ccagtcacaa tgccacagta gccatattga ggcaccatga agacgtcatt     1200

ggggaaagga ggcagacttc cctcttgtcc agcgtccatc acgtacggga gctcatacga     1260

cgagtccgca aatatctgaa ccgtgctggt aaggttatta gcgaccgtag tctcgccgtt     1320

cgacgttgtg acctccttaa cttggatatt gaagatttta acgcgcatgg cttttggtcg     1380

tagtccccag ttgttgttga tgagtctttg ccagtcacgt ggtgagaagt gacagtggaa     1440

tctgttaaag tcaaagtatc cccagggggt ggagaatccg ttgtaggtgt tgctgtttga     1500

tgttgttccg agccgcaggt acaagtggtt gttgtaggtg ggcaagaccc aggttctggt     1560

cgaggttgtt gtgaccttgc cctcagacca ggtggaatcg caatgccaat cacccgaggc     1620

attacccact ccatcggaac cttgtcccgc atcgacagca tttccgcccg gtgctgcacg     1680

catttcaatg tctgaagaca tggcgctggt atctgatcct tcagggggtc cgtctccggc     1740

tccagtgtcc tcttcaaagt tgagtctctt tttggctggt tgtttgcctt ttttgccgat     1800

tcctgaggag gagtcgggct cttgtggtga ctctaacggt ctcttctttc caggagccgt     1860

cttagcacct tcttcaacca ggcccagagg ttcgagtacc ctcttcttgg cctggaagac     1920

tgctcgcccg aggttgcccc caaaagacgt atcttcttgc agacgctcct gaaactcggc     1980

gtcggcgtgg ttataccgca ggtacggatt gtcacccgct ttgagctgct ggtcgtaggc     2040

cttgtcgtgc tcgagggccg ctgcgtccgc cgcgttgacg ggctccccct tgtcgagtcc     2100

gttgaagggt ccgaggtact cgtagccagg aagcaccaga ccccggccgt cgtcctgctt     2160

ctgctggttg gccttgggct tgggggctcc aggtttcagg tcccaccact cgcgaatgcc     2220

ctcagagagg ttgtcctcga gccaatctgg aagataaccg tcagcagcca tacctggttt     2280

aagtcattta ttgctcagaa acacagtcat ccaagtccac gttgacgaga tcgcaggccg     2340

aacacgcaat ctcgggtgcc cgccccagca gatgatgaat cgcgcacagt ttctgatacg     2400

tcttttttct gacgacgggt tgagattctg acgcgccggg gaagcactct gagcagtctc     2460

tgaccccgtg cgtgaagcag acgttgaaat tctgattcat tctctcgcat gtcttgcagg     2520

gaaacagcat ctgaagcatg cccgcgtgac gagaacattt gttttggtac ctgtccgcaa     2580

ggtccaccgg tgcttccgcg tctgacgtcg atggctccgc aactgagggg caggcccgct     2640

tgggctcgct tatatccgcg tcactggggg cgggtctttt ggtggctccg ccctttctga     2700

cgtagaactc atgcgccacc tcagtcacgt gatcctgagc ccagcggaag aactctttga     2760

cttcctgctt ggtcaccttg ccaaagtcgt gctccagacg gcgggtgagc tcgaacttga     2820

acatgcggtc ctgcagcggc tgctggtgct cgaaggtggt gctgttcccg tcgatcacgg     2880

cgcacatgtt ggtgttggag gtgacgatca cgggcgtggg gtcgatctgg gccgatgact     2940

tgcacttttg gtccacgcgc accttgcttc cgcccagaat ggccttggcg gactccacga     3000

ccttggcggt catcttgccc tcctcccacc agatcaccat cttgtcgacg caatcgttga     3060

agggaaagtt ctcattggtc cagttgacgc agcaagggcg aattc                     3105


<210> 5015
<211> 3094
<212> DNA
<213> Adeno-associated virus

<400> 5015
gaattcgccc ttgctgcgtc aactggacca agagaacttt cccttcaacg attgcgtcga       60

caagatggtg atctggtggg aggagggcaa gatgacggcc aaggtcgtgg agtccgccaa      120

agccattctg ggcggaagca aggtgcgcgt cgaccaaaag tgcaagtcct cggcccagat      180

cgatcccacc cccgtgatcg tcacctccaa caccaacatg tgcgccgtga tcgacgggaa      240

cagcaccacc ttcgagcacc agcagccgtt gcaggaccgg atgttcaaat ttgaactcac      300

ccgccgtctg gaacacgact ttggcaaggt gaccaagcag gaagtcaaag agttcttccg      360

ctgggctagt gatcacgtga ctgaggtgac gcatgagttc tacgtcagaa agggcggagc      420

cagcaaaaga cccgcccccg atgacgcgga tataagcgag cccaagcggg cctgtccctc      480

agtcacggac ccatcgacgt cagacgcgga aggagctccg gtggactttg ccgacaggta      540

ccaaaacaaa tgttctcgtc acgcgggcat gcttcagatg ctgtttccct gcaaaacgtg      600

cgagagaatg aatcagaatt tcaacatttg cttcacgcac ggggtcagag actgtttaga      660

atgtttcccc ggcgtgtcag aatctcaacc ggtcgtcaga aaaaagacgt atcggaagct      720

gtgtgcgatt catcatctgc tggggcgggc acccgagatt gcttgctcgg cctgcgacct      780

ggtcaacgtg gacctggacg actgtgtttc tgagcaataa atgacttaaa ccgggtatgg      840

ctgccgatgg ttatcttcca gattggctcg aggacaacct ctctgagggc attcgcgagt      900

ggtgggacct gaaacctgga gccccgaaac ccaaagccaa ccagcaaaag caggacgacg      960

gccggggtct ggtgcttcct ggctacaagt acctcggacc cttcaacgga ctcgacaagg     1020

gggagcccgt caacgcggcg gacgcagcgg ccctcgagca cgacaaggcc tacgaccagc     1080

agctcaaagc gggtgacaat ccgtacctgc ggtataacca cgccgacgcc gagtttcagg     1140

agcgtctgca agaagatacg tcatttgggg gcaacctcgg gcgagcagtc ttccaggcca     1200

agaagcgggt tctcgaacct ctcggtctgg ttgaggaagg cgctaagacg gctcctggaa     1260

agaagagacc catagactct ccagactcct ccacgggcat cggcaaaaaa ggccagcagc     1320

ccgctaaaaa gaagctcaat tttggtcaga ctggcgactc agagtcagtc cccgaccctc     1380

aacctcttgg agaacctcca gcagcgccct ctagtgtggg atctggtaca atggctgcag     1440

gcggtggcgc accaatggca gacaataacg aaggtgccga cggagtgggt aatgcctcag     1500

gaaattggca ttgcgattcc acatggctgg gcgacagagt catcaccacc agcaccagaa     1560

cctgggccct ccccacctac aacaaccacc tctacaagca aatctccagc agcagctcag     1620

gagccaccaa tgacaaccac tacttcggct acagcacccc ctgggggtat tttgacttta     1680

acagattcca ctgccacttc tcaccacgtg actggcagcg actcatcaac aacaactggg     1740

gattccggcc caagaagctg cggttcaagc tcttcaacat ccaggtcaag gaggtcacaa     1800

cgaatgacgg cgtcacgacc atcgctaata accttaccag cacggttcag gtcttctcgg     1860

actcggaata ccagctgccg tacgtcctcg gctctgcgca ccagggctgc ctgcctccgt     1920

tcccggcgga cgtcttcatg attcctcagt acggctacct gactctgaac aacggcagcc     1980

aatcggtggg ccgttcctcc ttctactgcc tggaatattt cccctctcaa atgctgagaa     2040

cgggcaacaa ctttgagttc agttacagct tcgaggacgt gcctttccac agcagctacg     2100

cgcacagcca gagcctagac cggctgatga accctctcat cgaccagtac ctgtactacc     2160

tggcccggac ccagagcacc acgggttcca ccagggaact gcaatttcat caagctgggc     2220

ccaatactat ggccgagcag tcaaagaact ggctgcctgg accctgctat aggcaacagg     2280

gactgtcaaa gaacttggac tttaacaaca acagcaattt tgcctggact gctgccacta     2340

aatatcatct gaatggcaga aactctttga ccaatcctgg cattcccatg gcaaccaaca     2400

aggatgatga ggaccagttc tttcccatca acggggtact ggtttttggc aagacgggag     2460

ctgccaacaa aactacgctg gaaaacgttc tgatgaccag cgaggaggag atcaagacca     2520

ctaaccctgt ggctacagaa gaatacggtg tggtctccag caacctgcag ccgtctacag     2580

ccgggcctca atcacagact atcaacagcc agggagcact gcctggcatg gtctggcaga     2640

accgggacgt gtatctgcag ggtcccatct gggccaaaat tcctcacacg gatggcaact     2700

ttcacccgtc tcctctgatg ggcggttttg gactcaaaca cccgcctcca cagatcctga     2760

tcaaaaacac acctgtacct gctaatcctc cggaggtgtt tactcctgcc aagtttgcct     2820

ccttcatcac gcagtacagc accggacaag tcagcgtgga aatcgagtgg gagctgcaga     2880

aagaaaacag caagcgctgg aacccagaaa ttcagtatac ttccaattat gccaagtcta     2940

ataatgttga atttgctgtg aaccctgatg gtgtttatac tgagcctcgc cccattggca     3000

ctcgttacct cccccgtaat ctgtaattgc ttgttaatca ataaaccggt tgattcgttt     3060

cagttgaact ttggtctctg cgaagggcga attc                                 3094


<210> 5016
<211> 3095
<212> DNA
<213> Adeno-associated virus

<400> 5016
gaattcgccc ttcgcagaga ccaaagttca actgaaacga atcaaccggt ttattgatta       60

acaagcaatt acagattacg ggtgaggtaa cgagtgccaa tggggcgagg ctcagtataa      120

acaccatcag ggttcacagc aaattcaaca ttattagact tggcataatt ggaagtatac      180

tgaatttctg ggttccagcg cttgctgttt tctttctgca gctcccactc gatttccacg      240

ctgacttgtc cggtgctgta ctgcgtgatg aaggaggcaa acttggcagg agtaaacacc      300

tccggaggat tagcaggtac aggtgtgttt ttgatcagga tctgtggagg cgggtgtttg      360

agtccaaaac cgcccatcag aggagacggg tgaaagttgc catccgtgtg aggaattttg      420

gcccagatgg gaccctgcag atacacgtcc cggttctgcc agaccatgcc aggcagtgct      480

ccctggctgt tgatagtctg tgattgaggc ccggctgtag acgactgcag gttgctggag      540

accacaccgt attcttctgt agccacaggg ttagtggtct tgatctcctc ctcgctggtc      600

atcagaacgt tttccagcgt agttttgttg gcagctcccg tcttgccaaa aaccagtacc      660

ccgttgatgg gaaagaactg gtcctcatca tccttgttgg ttgccatggg aatgccagga      720

ttggtcaaag agtttctgcc attcagatga tatttagtgg cagcagtcca ggcaaaattg      780

ctgttgttgt taaagtccaa gttctttgac agtctctgtt gcctatagca gggtccaggc      840

agccagttct ttgactgctc ggccatagta ttgggcccag cttgatgaaa ttgcagttcc      900

ctggtggaac ccgtggtgct ctgggtccgg gccaggtagt acaggtactg gtcgatgaga      960

gggttcatca gccggtctag gctctggctg tgcgcgtagc tgctgtggaa aggcacgtcc     1020

tcgaagctgt aactgaactc aaagttgttg cccgttctca gcatttgaga ggggaaatat     1080

tccaggcagt agaaggagga acggcccacc gattggctgc cgttgtccag agtcaggtag     1140

ccgtactgag gaatcatgaa gacgtccgcc gggaacggag gcaggcagcc ctggtgcgca     1200

gagccgagga cgtacggcag ctggtattcc gagtccgaga agacctgaac cgtgctggta     1260

aggttattag cgatggtcgt gacgccgtca ttcgttgtga cctccttgac ctggatgttg     1320

aggagcttga accgcagctt cttgggccgg aatccccagt tgttgttgat gagtcgctgc     1380

cagtcacgtg gtgagaagtg gcagtggaat ctgttaaagt caaaataccc ccagggggtg     1440

ctgtagccga agtagtggtt gtcattggtg gctcctgagc tgctgctgga gatttgcttg     1500

tagaggtggt tgttgtaggt ggggagggcc caggttctgg tgctggtggt gatgactctg     1560

tcgcccagcc atgtggaatc gcaatgccaa tttcctgagg cattacccac tccgtcggca     1620

ccttcgttat tgtctgccat tggtgcgcca ccgcctgcag ccattgtacc agatcccaca     1680

ctagagggcg ctgctggagg ttctccaaga ggttgagggt cggggactga ctctgagtcg     1740

ccagtctgac caaaattgag cttcttttta gcgggctgct ggcctttttt gccgatgccc     1800

gtggaggagt ctggagagcc tatgggtctc ttctttccag gagccgtctt agcgccttcc     1860

tcaaccagac cgagaggttc gagaacccgc ttcttggcct ggaagactgc tcgcccgagg     1920

ttgcccccaa atgacgtatc ttcttgcaga cgctcctgaa actcggcgtc ggcgtggtta     1980

taccgcaggt acggattgtc acccgctttg agctgctggt cgtaggcctt gtcgtgctcg     2040

agggccgctg cgtccgccgc gttgacgggc tcccccttgt cgagtccgtt gaagggtccg     2100

aggtacttgt agccaggaag caccagaccc cggccgtcgt cctgcttttg ctggttggct     2160

ttgggtttcg gggctccagg tttcaggtcc caccactcgc gaatgccctc agagaggttg     2220

tcctcgagcc aatctggaag ataaccatcg gcagccatac ctggtttaag tcatttattg     2280

ctcagaaaca cagtcgtcca ggtccacgtt gaccaggtcg caggccgagc aagcaatctc     2340

gggtgcccgc cccagcagat gatgaatcgc acacagcttc cgatacgtct tttttctgac     2400

gaccggttga gattctgaca cgccggggaa acattctaaa cagtctctga ccccgtgcgt     2460

gaagcaaatg ttgaaattct gattcattct ctcgcacgtt ttgcagggaa acagcacctg     2520

aagcatgccc gcgtgacgag aacatttgtt ttggtacctg tcggcaaagt ccaccggagc     2580

tccttccgcg tctgacgtcg atgggtccgt gactgaggga cgggcccgct tgggctcgct     2640

tatatccgcg tcatcggggg cgggtctttt gctggctccg ccctttctga cgtagaactc     2700

atgcgtcacc tcagtcacgt gatcactagc ccagcggaag aactctttga cttcctgctt     2760

tgtcaccttg ccaaagtcgt gttccagacg gcgggtgagt tcaaatttga acatccggtc     2820

ctgcaacggt tgctggtgct cgaaggtggt gctgttcccg tcgatcacgg cgcacatgtt     2880

ggtgttggag gtgacgatca cgggggtggg atcgatctgg gcggacgact tgcacttttg     2940

gtccacgcgc accttgctgc cgccgagaat ggccttggcg gactccacga ccttggccgt     3000

catcttgccc tcctcccacc agatcaccat cttgtcgacg caatcgttga agggaaagtt     3060

ctcattggtc cagttgacgc agcaagggcg aattc                                3095


<210> 5017
<211> 3095
<212> DNA
<213> Adeno-associated virus

<400> 5017
gaattcgccc ttcgcagaga ccaaagttca actgaaacga atcaaccggt ttattgatta       60

acaagcaatt acagattacg ggtgaggtaa cgagtgccaa tggggcgagg ctcagtataa      120

acaccatcag ggttcacagc aaattcaaca ttattagact tggcataatt ggaagtatac      180

tgaatttctg ggttccagcg cttgctgttt tctttctgca gctcccactc gatttccacg      240

ctgacttgtc cggtgctgta ctgcgtgatg aaggaggcaa acttggcagg agtaaacacc      300

tccggaggat tagcaggtac aggtgtgttt ttgatcagga tctgtggagg cgggtgttcg      360

agtccaaaac cgcccatcag aggagacggg tgaaagttgc catccgtgtg aggaattttg      420

gcccagatgg gaccctgcag atacacgtcc cggttctgcc agaccatgcc aggcagtgct      480

ccctggctgt tgatagtctg tgattgaggc ccggctgtag acgactgcag gttgctggag      540

accacaccgt attcttctgt agccacaggg ttagtggtct tgatctcctc ctcgctggtc      600

atcagaacgt tttccagcgt agttttgttg gcagctcccg tcttgccaaa aaccagtacc      660

ccgttgatgg gaaagaactg gtcctcatca tccttgttgg ttgccatggg aatgccagga      720

ttggtcaaag agtttctgcc attcagatga tatttagtgg cagcagtcca ggcaaaattg      780

ctgttgttgt taaagtccaa gttctttgac agtctctgtt gcctatagca gggtccaggc      840

agccagttct ttgactgctc ggccatagta ttgggcccag cttgatgaaa ttgcagttcc      900

ctggtggaac ccgtggtgct ctgggtccgg gccaggtagt acaggtactg gtcgatgaga      960

gggttcatca gccggtctag gctctggctg tgcgcgtagc tgctgtggaa aggcacgtcc     1020

tcgaagctgt aactgaactc aaagttgttg cccgttctca gcatttgaga ggggaaatat     1080

tccaggcagt agaaggagga acggcccacc gattggctgc cgttgttcag agtcaggtag     1140

ccgtactgag gaatcatgaa gacgtccgcc gggaacggag gcaggcagcc ctggtgcgca     1200

gagccgagga cgtacggcag ctggtattcc gagtccgaga agacctgaac cgtgctggta     1260

aggttattag cgatggtcgt gacgccgtca ttcgttgtga cctccttgac ctggatgttg     1320

aagagcttga accgcagctt cttgggccgg aatccccagt tgttgttgat gagtcgctgc     1380

cagtcacgtg gtgagaagtg gcagtggaat ctgttaaagt caaaataccc ccagggggtg     1440

ctgtagccga agtagtggtt gtcattggtg gctcctgagc tgctgctgga gatttgcttg     1500

tagaggtggt tgttgtaggt ggggagggcc caggttctgg tgctggtggt gatgactctg     1560

tcgcccagcc atgtggaatc gcaatgccaa tttcctgagg cattacccac tccgtcggca     1620

ccttcgttat tgtctgccgt tggtgcgcca ccgcctgcag ccattgtacc agatcccaca     1680

ctagagggcg ctgctggagg ttctccaaga ggttgagggt cggggactga ctctgagtcg     1740

ccagtctgac caaaattgag cttcttttta gcgggctgct ggcctttttt gccgatgccc     1800

gtggaggagt ctggagagtc tatgggtctc ttctttccag gagccgtctt agcgccttcc     1860

tcaaccagac cgagaggttc gagaacccgc ttcttggcct ggaagactgc tcgcccgagg     1920

ttgcccccaa atgacgtatc ttcttgcagg cgctcctgaa actcggcgtc ggcgtggtta     1980

taccgcaggt acggattgtc acccgctttg agctgctggt cgtaggcctt gtcgtgctcg     2040

agggccgctg cgtccgccgc gttgacgggc tcccccttgt cgagtccgtt gaagggtccg     2100

aggtacttgt agccaggaag caccagaccc cggccgtcgt cctgcttttg ctggttggct     2160

ttgggtttcg gggctccagg tttcaggtcc caccactcgc gaatgccctc agagaggttg     2220

tcctcgagcc aatctggaag ataaccatcg gcagccatac ctggtttaag ccatttattg     2280

ctcagaaaca cagtcgtcca ggtccacgtt gaccaggtcg caggccgagc aggcaatctc     2340

gggtgcccgc cccagcagat gatgaatcgc acacagcttc cgatacgtct tttttctgac     2400

gaccggttga gattctgaca cgccggggaa acattctaaa cagtctctga ccccgtgcgt     2460

gaagcaaatg ttgaaattct gattcattct ctcgcacgtt ttgcagggaa acagcatctg     2520

aagcatgccc gcgtggcgag aacatttgtt ttggtacctg tcggcaaagt ccaccggagc     2580

tccttccgcg tctgacgtcg atgggtccgt gactgaggga caggcccgct tgggctcgct     2640

tatatccgcg tcatcggggg cgggtctttt gctggctccg ccctttctga cgtagaactc     2700

atgcgtcacc tcagtcacgt gatcactagc ccagcggaag aactctttga cttcctgctt     2760

tgtcaccttg ccaaagtcgt gttccagacg gcgggtgagt tcaaatttga acatccggtc     2820

ctgcaacggc tgctggtgct cgaaggtggt gctgttcccg tcgatcacgg cgcgcatgtt     2880

ggtgttggag gtgacgatca cgggggtggg atcgatctgg gcggacgact tgcacttttg     2940

gtccacgcgc accttgctgc cgccgagaat ggccttggcg gactccacga ccttggccgt     3000

catcttgccc tcctcccacc agatcaccat cttgtcgacg caatcgttga agggaaagtt     3060

ctcattggtc cagttgacgc agcaagggcg aattc                                3095


<210> 5018
<211> 729
<212> PRT
<213> Adeno-associated virus

<400> 5018
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Asp Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Thr Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Ser Ser Ser Gly Ala Thr Asn Asp Asn His Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr 
        435                 440                 445             


Thr Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr 
    450                 455                 460                 


Met Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln 
465                 470                 475                 480 


Gln Arg Leu Ser Lys Asn Leu Asp Phe Asn Asn Asn Ser Asn Phe Ala 
                485                 490                 495     


Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr 
            500                 505                 510         


Asn Pro Gly Ile Pro Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe 
        515                 520                 525             


Phe Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn 
    530                 535                 540                 


Lys Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys 
545                 550                 555                 560 


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn 
                565                 570                 575     


Leu Gln Ser Ser Thr Ala Gly Pro Gln Ser Gln Thr Ile Asn Ser Gln 
            580                 585                 590         


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
        595                 600                 605             


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
    610                 615                 620                 


Ser Pro Leu Met Gly Gly Phe Gly Leu Glu His Pro Pro Pro Gln Ile 
625                 630                 635                 640 


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr 
                645                 650                 655     


Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
            660                 665                 670         


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
        675                 680                 685             


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val 
    690                 695                 700                 


Glu Phe Ala Val Asn Pro Asp Gly Val Tyr Thr Glu Pro Arg Pro Ile 
705                 710                 715                 720 


Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 


<210> 5019
<211> 729
<212> PRT
<213> Adeno-associated virus

<400> 5019
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Asp Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Thr Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Ser Ser Ser Gly Ala Thr Asn Asp Asn His Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr 
        435                 440                 445             


Thr Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr 
    450                 455                 460                 


Met Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln 
465                 470                 475                 480 


Gln Arg Leu Ser Lys Asn Leu Asp Phe Asn Asn Asn Ser Asn Phe Ala 
                485                 490                 495     


Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr 
            500                 505                 510         


Asn Pro Gly Ile Pro Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe 
        515                 520                 525             


Phe Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn 
    530                 535                 540                 


Lys Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys 
545                 550                 555                 560 


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn 
                565                 570                 575     


Leu Gln Ser Ser Thr Ala Gly Pro Gln Ser Gln Thr Ile Asn Ser Gln 
            580                 585                 590         


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
        595                 600                 605             


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
    610                 615                 620                 


Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile 
625                 630                 635                 640 


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr 
                645                 650                 655     


Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
            660                 665                 670         


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
        675                 680                 685             


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val 
    690                 695                 700                 


Glu Phe Ala Val Asn Pro Asp Gly Val Tyr Thr Glu Pro Arg Pro Ile 
705                 710                 715                 720 


Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 


<210> 5020
<211> 729
<212> PRT
<213> Adeno-associated virus

<400> 5020
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Asp Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Ser Ser Ser Gly Ala Thr Asn Asp Asn His Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr 
        435                 440                 445             


Thr Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr 
    450                 455                 460                 


Met Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln 
465                 470                 475                 480 


Gln Arg Leu Ser Lys Asn Leu Asp Phe Asn Asn Asn Ser Asn Phe Ala 
                485                 490                 495     


Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr 
            500                 505                 510         


Asn Pro Gly Ile Pro Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe 
        515                 520                 525             


Phe Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn 
    530                 535                 540                 


Lys Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys 
545                 550                 555                 560 


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn 
                565                 570                 575     


Leu Gln Ser Ser Thr Ala Gly Pro Gln Ser Gln Thr Ile Asn Ser Gln 
            580                 585                 590         


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
        595                 600                 605             


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
    610                 615                 620                 


Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile 
625                 630                 635                 640 


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr 
                645                 650                 655     


Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
            660                 665                 670         


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
        675                 680                 685             


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val 
    690                 695                 700                 


Glu Phe Ala Val Asn Pro Asp Gly Val Tyr Thr Glu Pro Arg Pro Ile 
705                 710                 715                 720 


Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 


<210> 5021
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5021
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tacaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcggcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gcccttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgcacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgctacc tcacccgtaa tctgtaa        2217


<210> 5022
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5022
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Arg Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Pro Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu His Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5023
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5023
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg ataacttgca gcaaaccaat acggggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210> 5024
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5024
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5025
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5025
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asp Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Arg Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Ala Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Ser Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5026
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5026
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcaggatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcgggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg ttgctatggc aacgcataag gacgacgagg aacgtttctt tccatcgagc     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta tagcagcgtt     1680

atgctaacca gcgaggaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaagccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaaa ttcctcacac ggacggcaat tttcacccgt ctcctctgat gggcggcttt     1920

ggactgaagc acccacctcc ccagatcctg atcaagaata cgccggtacc tgcggatcct     1980

ccaacgacgt tcagccaggc aaaattggct tccttcatca cgcagtacag caccggccag     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgatg gaacccagaa     2100

attcagtaca cttccaacta ctacaaatct acaaatgtgg actttgctgt caattctgag     2160

ggtacatatt cagagcctcg ccccattggt actcgttatc tgacacgtaa tctgtaa        2217


<210> 5027
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 5027
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gcctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctcg aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccagtaga gcagtcaccc caagaaccag actcctcctc gggcatcggc      480

aagaaaggcc aacagcccgc cagaaaaaga ctcaattttg gccagactgg cgactcagag      540

tcagttccag accctcaacc tctcggagaa cctccagcag cgccctctgg tgtgggacct      600

aatacaatgg ctgcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta cggctaccta     1140

acactcaaca acggtagtca ggccgtggga cgctcctcct tctactgcct ggaatacttt     1200

ccttcgcaga tgctgagaac cggcaacaac ttccagttta cttacacctt cgaggacgtg     1260

cctttccaca gcagctacgc ccacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacgaggagc gttttttccc agtaacggga     1620

tcctgttttt ggcaacaaaa tgctgccaga gacaatgcgg attacagcga tgtcatgctc     1680

accagcgagg aagaaatcaa aaccactaac cctgtggcta cagaggaata cggtatcgtg     1740

gcagataact tgcagcagca aaacacggct cctcaaattg gaactgtcaa cagccagggg     1800

gccttacccg gtatggtctg gcagaaccgg gacgtgtacc tgcagggtcc catctgggcc     1860

aagattcctc acacggacgg caacttccac ccgtctccgc tgatgggcgg ctttggcctg     1920

aaacatcctc cgcctcagat cctgatcaag aacacgcctg tacctgcgga tcctccgacc     1980

accttcaacc agtcaaagct gaactctttc atcacgcaat acagcaccgg acaggtcagc     2040

gtggaaattg aatgggagct acagaaggaa aacagcaagc gctggaaccc cgagatccag     2100

tacacctcca actactacaa atctacaagt gtggactttg ctgttaatac agaaggcgtg     2160

tactctgaac cccgccccat tggcacccgt tacctcaccc gtaatctgta a              2211


<210> 5028
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 5028
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His 
        515                 520                 525             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Val Thr Gly Ser Cys Phe Trp 
    530                 535                 540                 


Gln Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met Leu 
545                 550                 555                 560 


Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro Gln 
            580                 585                 590         


Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5029
<211> 2214
<212> DNA
<213> Adeno-associated virus

<400> 5029
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcagcgc ggcggacgca gcggccctcg agcacgacaa ggcctgcgac      240

cagcggctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaagg gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggctg acaataacga gggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaatcacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cttgcttccg gcaacaaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga cgaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210> 5030
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5030
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Ser Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Cys Asp 
65                  70                  75                  80  


Gln Arg Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Gly 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Glu Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5031
<211> 2214
<212> DNA
<213> Adeno-associated virus

<400> 5031
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttcctcagta cggctacctg     1140

actctcaaca acggtagtca ggccgtggga cgttcctcct tctactgcct ggagtacttc     1200

ccctctcaga tgctgagaac gggcaacaac ttttccttca gctacacttt cgaggacgtg     1260

cctttccaca gcagctacgc gcacagccag agtttggaca ggctgatgaa tcctctcatc     1320

gaccagtacc tgtactacct gtcaagaacc cagtctacgg gaggcacagc gggaacccag     1380

cagttgctgt tttctcaggc cgggcctagc aacatgtcga ctcaggccag aaactggctg     1440

cctggaccct gctacagaca gcagcgcgtc tccacgacac tgtcgcaaaa caacaacagc     1500

aactttgcct ggactggtgc caccaagtat catctgaacg gcagagactc tctggtgaat     1560

ccgggcgtcg ccatggcaac caacaaggac gacgaggacc gcttcttccc atccagcggc     1620

atcctcatgt ttggcaagca gggagctgga aaagacaacg tggactatag caacgtgatg     1680

ctaaccagcg aggaagaaat caagaccacc aaccccgtgg ccacagaaca gtatggcgtg     1740

gtggctgata acctacagca gcaaaacacc gctcctattg tgggggccgt caacagccag     1800

ggagccttac ctggcatggt ctggcagaac cgggacgtgt acctgcaggg tcctatttgg     1860

gccaagattc ctcacacaga tggcaacttt cacccgtctc ctttaatggg cggctttgga     1920

cttaaacatc cgcctcctca gatccttatc aaaaacactc ctgttcctgc ggatcctcca     1980

acagcgttca accaggccaa gctgaattct ttcatcacgc agtacagcac cggacaagtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatactt ccaactacta caaatctaca aatgtggact ttgctgttaa tactgagggt     2160

gcttactctg agcctcgccc cattggcact cgttacctca cccgtaatct gtaa           2214


<210> 5032
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5032
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu Phe 
    450                 455                 460                 


Ser Gln Ala Gly Pro Ser Asn Met Ser Thr Gln Ala Arg Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr Asn 
        515                 520                 525             


Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met Phe 
    530                 535                 540                 


Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val Met 
545                 550                 555                 560 


Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro 
            580                 585                 590         


Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Ala Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5033
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5033
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaaggcc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5034
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5034
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5035
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5035
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagcacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgctga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacggttc aggtcttttc ggactcggaa taccagctgc cctacgtcct cggctccgca     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

ctgactctga acaatggcag ccaatcggtg ggtcgttcct ctttctactg cctggaatat     1200

ttcccttctc aaatgctgag aacgggcaac aacttcacct tcagctacac cttcgaggac     1260

gttcccttcc acagcagcta cgcacacagc cagagcctgg accggctgat gaatcctctt     1320

atcgaccagt acctgtatta cctggccaga acacagagca acgcaggagg cacagctggc     1380

aatcgggaac tgcagtttta tcagggcggg cctaccacca tggccgaaca agccaaaaac     1440

tggctgcctg gaccttgctt ccggcaacaa agagtctcca agacgctgga tcaaaacaac     1500

aacagcaact ttgcttggac tggtgccacc aaataccatc taaatggaag aaattcattg     1560

gttaatcccg gtgtcgccat ggcaacccac aaggacgacg aggaacgctt cttcccttcg     1620

agcggagtcc tgatttttgg aaaaactgga gcagctaata agactacact ggaaaatgtg     1680

ttaatgacaa atgaagagga aattcgtcct accaacccgg tagccaccga ggaatacggg     1740

actgttagca gcaacctgca ggcggctaac actgcagccc agacacaagt tgtcaacaac     1800

cagggagcct tacctggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac tttcacccgt ctccgctgat gggcggcttt     1920

ggactgaagc atccgcctcc tcagatcctg atcaaaaaca ctcctgttcc tgctaatccc     1980

ccggaggtgt ttacgcctgc caagtttgct tctttcatca cacagtacag caccggccag     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cctccaattt tgacaaacag actggtgtgg actttgccgt tgacagccag     2160

ggtgtttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210> 5036
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5036
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys His Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ala Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu 
    450                 455                 460                 


Gln Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn 
465                 470                 475                 480 


Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu 
                485                 490                 495     


Asp Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr 
            500                 505                 510         


His Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala 
        515                 520                 525             


Thr His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu 
    530                 535                 540                 


Ile Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val 
545                 550                 555                 560 


Leu Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala 
            580                 585                 590         


Ala Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5037
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5037
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Lys Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Ser 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5038
<211> 2214
<212> DNA
<213> Adeno-associated virus

<400> 5038
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggctg acaataacaa gggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca gcaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cttgcttccg gcaacaaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga caaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210> 5039
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5039
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Ser 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5040
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5040
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5041
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5041
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Lys Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5042
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5042
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgcac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acttatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggcaac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acatgggcta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacgg caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5043
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5043
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro His Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Leu Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Asn Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Met Gly Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Gly Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5044
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5044
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccggaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

gtcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gagcccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5045
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5045
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Gly Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Val Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Ser Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5046
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5046
atggttgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcagggc      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctta aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagctt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgcg ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gccagcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagccgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5047
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5047
Met Val Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Gly Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Leu Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Gln Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Pro Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5048
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5048
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa tagcctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactccca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgtcttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacttgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5049
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5049
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Ser Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Pro Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Ser Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5050
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5050
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Val His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Ser Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Pro Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5051
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5051
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgtgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aattcgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc ccacccgtaa tctgtaa        2217


<210> 5052
<211> 734
<212> PRT
<213> Adeno-associated virus

<400> 5052
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Arg Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Thr Ala Ser Gly Thr Gln Gln Ser Arg Leu Leu Phe Ser Gln Ala 
    450                 455                 460                 


Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly Pro 
465                 470                 475                 480 


Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn Asn 
                485                 490                 495     


Ser Asn Phe Pro Trp Thr Gly Ala Thr Lys Tyr Tyr Leu Asn Gly Arg 
            500                 505                 510         


Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp Asp 
        515                 520                 525             


Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys Glu 
    530                 535                 540                 


Gly Thr Asn Ala Thr Asn Ala Glu Leu Glu Asn Val Met Ile Thr Asp 
545                 550                 555                 560 


Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly 
                565                 570                 575     


Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Ala Ala Ser Thr Glu 
            580                 585                 590         


Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn 
    690                 695                 700                 


Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210> 5053
<211> 2214
<212> DNA
<213> Adeno-associated virus

<400> 5053
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca acctctcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct cttcaacatc      960

caagtcaagg aggtcacgac gaatgacggc gtcacgacca tcgctaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggagtac cagctgccgt acgtcctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttcctcagta cggctacctg     1140

actctgaaca atggcagcca atcggtggga cgttcatcct tctactgcct ggaatacttc     1200

ccttctcagg tgctgagaac gggtaacaac ttcaccttca gttacacctt cgaggacgtg     1260

cctttccaca gcagctacgc gcacagccag agcctagacc ggctgatgaa tcccctcatc     1320

gaccagtacc tgtattacct ggctagaaca cagagtaacc caggaggcac atctggcaat     1380

cgggaactgc agttttacca gggcgggcct tccaccatgg ccgaacaagc caagaactgg     1440

ttacctggac cttgcttccg gcaacaaaga gtttccaaaa cactggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggcagaaa ctcattggtg     1560

aatcctggtg tcgccatggc aactcacaag gacgacgagg accgcttttt cccatccagc     1620

ggagtcctga tttttggaaa aactggagca accaacaaga ctacattgga aaacgtgtta     1680

atgacaaatg aagaagaaat tcgtcctact aatcctgtgg ccacagaaga atacgggata     1740

gtcagcagca atttacaagc ggccaatact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggcatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaaaattc ctcacacaga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga caaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210> 5054
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5054
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Val Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Pro Gly Gly Thr Ser Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5055
<211> 2214
<212> DNA
<213> Adeno-associated virus

<400> 5055
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca cacggctggg cgacagagtc      720

atcaccacca gcacccggac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cttgcttccg gcaacgaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga caaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210> 5056
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5056
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Arg Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Arg Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5057
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 5057
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cttcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggcccagccc acctacaaca accacctcta caagcaaatc      780

tcaagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcgggtcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtactggaaa caactttcag ttcagctaca cctttgaaga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa aacacaatca aatagtggag ctcttcagca gtctcggcta     1380

ctgtttagtc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctacctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtaccaccta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggacaatgt catgattaca     1680

gatgaagaag aaatccgcac caccaatccc gtggctacgg agcagtacgg atatgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actactggaa ctgtcaatca ccgaggagcg     1800

ttacctggca tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tgggctcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaagagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 5058
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 5058
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Gln Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Ala Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Arg Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5059
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5059
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgcg ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

acctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgcgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5060
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5060
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Thr Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Ala Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5061
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5061
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggccgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagctgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaagca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagtgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5062
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5062
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Ser Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Cys Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5063
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5063
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Ser Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5064
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5064
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggctg acaataacga gggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccctaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5065
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5065
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Pro Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5066
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 5066
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcac       60

gagtggtggg acccgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacccaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaacg tctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgtcact tctcaccacg tgaccggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cggaaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc ctcagatcct gatcaaaaac actcctgttc ctgctaatcc cccggaggtg     1980

tttacgcctg ccaagtttgc ttctttcatc acacagtaca gcaccggcca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaagcgct ggaacccaga gattcagtat     2100

acctccaatt ttgacaaaca gactggtgtg gactttgccg ttgacagcca gggtgtttat     2160

tctgagcctc gccccattgg tactcgttac ctcacccgta atctgtaa                  2208


<210> 5067
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 5067
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile His Glu Trp Trp Asp Pro Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr His Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Arg Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Glu Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Phe 
    690                 695                 700                 


Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5068
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5068
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Pro Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Pro Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asp Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Val Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5069
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5069
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaagg ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgacccatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctaccc tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaagac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcaggtcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5070
<211> 2214
<212> DNA
<213> Adeno-associated virus

<400> 5070
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttc      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggctgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gagccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggctg acaataacaa gggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gggtgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atgacagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cttgcttccg gcaacaaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga caaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210> 5071
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5071
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Ala Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Lys Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Gly Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Asp Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5072
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5072
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgtgtg ggagctgcag aaggagaaca gcaagcgcag gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5073
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5073
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Val Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Arg Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5074
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5074
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5075
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5075
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Val Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5076
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5076
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5077
<211> 2214
<212> DNA
<213> Adeno-associated virus

<400> 5077
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctagac cttgcttccg gcaacaaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga caaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210> 5078
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5078
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Arg Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5079
<211> 2214
<212> DNA
<213> Adeno-associated virus

<400> 5079
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accatgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcctccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cttgcttccg gcaacaaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga caaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210> 5080
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5080
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5081
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5081
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Leu Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5082
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5082
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccacccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg tgatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcttcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5083
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5083
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Pro Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Val Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Leu Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5084
<211> 2214
<212> DNA
<213> Adeno-associated virus

<400> 5084
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgcc ccaatggcag acaataacga aggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccatca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

caggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cttgcttccg gcaacaaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacaga tggcaacttt cacccgtctc ctttaatggg cggctttgga     1920

cttaaacatc cgcctcctca gatcctcatc aaaaacactc ctgttcctgc ggatcctcca     1980

acagcgttca accaggccaa gctgaattct ttcatcacgc agtacagcac cggacaagtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatactt ccaactacta caaatctaca aatgtggact ttgctgttaa tactgagggt     2160

gtttactctg agcctcgccc cattggcact cgttacctca cccgtaatct gtaa           2214


<210> 5085
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5085
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Ile Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Gln Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5086
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5086
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccgcctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gatgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga gcggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tcttccatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tttgtaa        2217


<210> 5087
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5087
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Ala Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Ser Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Ser 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5088
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 5088
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5089
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5089
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210> 5090
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5090
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Arg Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5091
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 5091
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Leu Asn Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Asp Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Gly 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Lys Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Ser Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Ser Pro His Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Glu Ala Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ser Asp Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys 
        435                 440                 445             


Thr Gln Gly Thr Asn Ala Thr Val Gln Gly Ala Lys Leu Gln Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Asn Met Arg Asp Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Glu Tyr Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met Asn Gly Thr Leu Val Phe Gly 
    530                 535                 540                 


Lys Asn Gly Ala Gly Asn Ser Asn Val Asp Ile Glu Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Val Val Ser Asp Asn Leu Gln Ser Ser Asn Thr Arg Pro Ile 
            580                 585                 590         


Thr Gly Asp Val Asp Ser Gln Gly Val Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Ala Thr Thr Phe Thr Pro Gly Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Gln Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5092
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 5092
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Asp Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5093
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 5093
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5094
<211> 2211
<212> DNA
<213> Adeno-associated virus 1

<400> 5094
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg atccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 5095
<211> 736
<212> PRT
<213> Adeno-associated virus 1

<400> 5095
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5096
<211> 4718
<212> DNA
<213> Adeno-associated virus 1

<400> 5096
ttgcccactc cctctctgcg cgctcgctcg ctcggtgggg cctgcggacc aaaggtccgc       60

agacggcaga gctctgctct gccggcccca ccgagcgagc gagcgcgcag agagggagtg      120

ggcaactcca tcactagggg taatcgcgaa gcgcctccca cgctgccgcg tcagcgctga      180

cgtaaattac gtcatagggg agtggtcctg tattagctgt cacgtgagtg cttttgcgac      240

attttgcgac accacgtggc catttagggt atatatggcc gagtgagcga gcaggatctc      300

cattttgacc gcgaaatttg aacgagcagc agccatgccg ggcttctacg agatcgtgat      360

caaggtgccg agcgacctgg acgagcacct gccgggcatt tctgactcgt ttgtgagctg      420

ggtggccgag aaggaatggg agctgccccc ggattctgac atggatctga atctgattga      480

gcaggcaccc ctgaccgtgg ccgagaagct gcagcgcgac ttcctggtcc aatggcgccg      540

cgtgagtaag gccccggagg ccctcttctt tgttcagttc gagaagggcg agtcctactt      600

ccacctccat attctggtgg agaccacggg ggtcaaatcc atggtgctgg gccgcttcct      660

gagtcagatt agggacaagc tggtgcagac catctaccgc gggatcgagc cgaccctgcc      720

caactggttc gcggtgacca agacgcgtaa tggcgccgga ggggggaaca aggtggtgga      780

cgagtgctac atccccaact acctcctgcc caagactcag cccgagctgc agtgggcgtg      840

gactaacatg gaggagtata taagcgcctg tttgaacctg gccgagcgca aacggctcgt      900

ggcgcagcac ctgacccacg tcagccagac ccaggagcag aacaaggaga atctgaaccc      960

caattctgac gcgcctgtca tccggtcaaa aacctccgcg cgctacatgg agctggtcgg     1020

gtggctggtg gaccggggca tcacctccga gaagcagtgg atccaggagg accaggcctc     1080

gtacatctcc ttcaacgccg cttccaactc gcggtcccag atcaaggccg ctctggacaa     1140

tgccggcaag atcatggcgc tgaccaaatc cgcgcccgac tacctggtag gccccgctcc     1200

gcccgcggac attaaaacca accgcatcta ccgcatcctg gagctgaacg gctacgaacc     1260

tgcctacgcc ggctccgtct ttctcggctg ggcccagaaa aggttcggga agcgcaacac     1320

catctggctg tttgggccgg ccaccacggg caagaccaac atcgcggaag ccatcgccca     1380

cgccgtgccc ttctacggct gcgtcaactg gaccaatgag aactttccct tcaatgattg     1440

cgtcgacaag atggtgatct ggtgggagga gggcaagatg acggccaagg tcgtggagtc     1500

cgccaaggcc attctcggcg gcagcaaggt gcgcgtggac caaaagtgca agtcgtccgc     1560

ccagatcgac cccacccccg tgatcgtcac ctccaacacc aacatgtgcg ccgtgattga     1620

cgggaacagc accaccttcg agcaccagca gccgttgcag gaccggatgt tcaaatttga     1680

actcacccgc cgtctggagc atgactttgg caaggtgaca aagcaggaag tcaaagagtt     1740

cttccgctgg gcgcaggatc acgtgaccga ggtggcgcat gagttctacg tcagaaaggg     1800

tggagccaac aaaagacccg cccccgatga cgcggataaa agcgagccca agcgggcctg     1860

cccctcagtc gcggatccat cgacgtcaga cgcggaagga gctccggtgg actttgccga     1920

caggtaccaa aacaaatgtt ctcgtcacgc gggcatgctt cagatgctgt ttccctgcaa     1980

gacatgcgag agaatgaatc agaatttcaa catttgcttc acgcacggga cgagagactg     2040

ttcagagtgc ttccccggcg tgtcagaatc tcaaccggtc gtcagaaaga ggacgtatcg     2100

gaaactctgt gccattcatc atctgctggg gcgggctccc gagattgctt gctcggcctg     2160

cgatctggtc aacgtggacc tggatgactg tgtttctgag caataaatga cttaaaccag     2220

gtatggctgc cgatggttat cttccagatt ggctcgagga caacctctct gagggcattc     2280

gcgagtggtg ggacttgaaa cctggagccc cgaagcccaa agccaaccag caaaagcagg     2340

acgacggccg gggtctggtg cttcctggct acaagtacct cggacccttc aacggactcg     2400

acaaggggga gcccgtcaac gcggcggacg cagcggccct cgagcacgac aaggcctacg     2460

accagcagct caaagcgggt gacaatccgt acctgcggta taaccacgcc gacgccgagt     2520

ttcaggagcg tctgcaagaa gatacgtctt ttgggggcaa cctcgggcga gcagtcttcc     2580

aggccaagaa gcgggttctc gaacctctcg gtctggttga ggaaggcgct aagacggctc     2640

ctggaaagaa acgtccggta gagcagtcgc cacaagagcc agactcctcc tcgggcatcg     2700

gcaagacagg ccagcagccc gctaaaaaga gactcaattt tggtcagact ggcgactcag     2760

agtcagtccc cgatccacaa cctctcggag aacctccagc aacccccgct gctgtgggac     2820

ctactacaat ggcttcaggc ggtggcgcac caatggcaga caataacgaa ggcgccgacg     2880

gagtgggtaa tgcctcagga aattggcatt gcgattccac atggctgggc gacagagtca     2940

tcaccaccag cacccgcacc tgggccttgc ccacctacaa taaccacctc tacaagcaaa     3000

tctccagtgc ttcaacgggg gccagcaacg acaaccacta cttcggctac agcaccccct     3060

gggggtattt tgatttcaac agattccact gccacttttc accacgtgac tggcagcgac     3120

tcatcaacaa caattgggga ttccggccca agagactcaa cttcaaactc ttcaacatcc     3180

aagtcaagga ggtcacgacg aatgatggcg tcacaaccat cgctaataac cttaccagca     3240

cggttcaagt cttctcggac tcggagtacc agcttccgta cgtcctcggc tctgcgcacc     3300

agggctgcct ccctccgttc ccggcggacg tgttcatgat tccgcaatac ggctacctga     3360

cgctcaacaa tggcagccaa gccgtgggac gttcatcctt ttactgcctg gaatatttcc     3420

cttctcagat gctgagaacg ggcaacaact ttaccttcag ctacaccttt gaggaagtgc     3480

ctttccacag cagctacgcg cacagccaga gcctggaccg gctgatgaat cctctcatcg     3540

accaatacct gtattacctg aacagaactc aaaatcagtc cggaagtgcc caaaacaagg     3600

acttgctgtt tagccgtggg tctccagctg gcatgtctgt tcagcccaaa aactggctac     3660

ctggaccctg ttatcggcag cagcgcgttt ctaaaacaaa aacagacaac aacaacagca     3720

attttacctg gactggtgct tcaaaatata acctcaatgg gcgtgaatcc atcatcaacc     3780

ctggcactgc tatggcctca cacaaagacg acgaagacaa gttctttccc atgagcggtg     3840

tcatgatttt tggaaaagag agcgccggag cttcaaacac tgcattggac aatgtcatga     3900

ttacagacga agaggaaatt aaagccacta accctgtggc caccgaaaga tttgggaccg     3960

tggcagtcaa tttccagagc agcagcacag accctgcgac cggagatgtg catgctatgg     4020

gagcattacc tggcatggtg tggcaagata gagacgtgta cctgcagggt cccatttggg     4080

ccaaaattcc tcacacagat ggacactttc acccgtctcc tcttatgggc ggctttggac     4140

tcaagaaccc gcctcctcag atcctcatca aaaacacgcc tgttcctgcg aatcctccgg     4200

cggagttttc agctacaaag tttgcttcat tcatcaccca atactccaca ggacaagtga     4260

gtgtggaaat tgaatgggag ctgcagaaag aaaacagcaa gcgctggaat cccgaagtgc     4320

agtacacatc caattatgca aaatctgcca acgttgattt tactgtggac aacaatggac     4380

tttatactga gcctcgcccc attggcaccc gttaccttac ccgtcccctg taattacgtg     4440

ttaatcaata aaccggttga ttcgtttcag ttgaactttg gtctcctgtc cttcttatct     4500

tatcggttac catggttata gcttacacat taactgcttg gttgcgcttc gcgataaaag     4560

acttacgtca tcgggttacc cctagtgatg gagttgccca ctccctctct gcgcgctcgc     4620

tcgctcggtg gggcctgcgg accaaaggtc cgcagacggc agagctctgc tctgccggcc     4680

ccaccgagcg agcgagcgcg cagagaggga gtgggcaa                             4718


<210> 5097
<211> 255
<212> DNA
<213> Adeno-associated virus 10

<400> 5097
ggtaattcct ccggaaattg gcattgcgat tccacatggc tgggcgacag agtcatcacc       60

accagcaccc gaacctgggt cctgcccacc tacaacaacc acatctacaa gcaaatctcc      120

agcgagacag gagccaccaa cgacaaccac tacttcggct acagcacccc ctgggggtat      180

tttgacttta acagattcca ctgccacttt tcaccacgtg actggcagcg actcatcaac      240

aacaactggg gattc                                                       255


<210> 5098
<211> 738
<212> PRT
<213> Adeno-associated virus 10

<400> 5098
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Glu Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Ala Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5099
<211> 738
<212> PRT
<213> Adeno-associated virus 10

<400> 5099
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5100
<211> 258
<212> DNA
<213> Adeno-associated virus 11

<400> 5100
ggtaattcct ccggaaattg gcattgcgat tccacatggc tgggcgacag agtcatcacc       60

accagcaccc gaacctgggc cctgccaacc tacaacaacc acctctacaa acaaatctcc      120

agcgcttcaa cgggggccag caacgacaac cactactttg gctacagcac cccctggggg      180

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatc      240

aacaacaact ggggattc                                                    258


<210> 5101
<211> 255
<212> DNA
<213> Adeno-associated virus 12

<400> 5101
ggtaattcct ccggaaattg gcattgcgat tccacatggc tgggcgaccg agtcattacc       60

accagcaccc ggacttgggc cctgcccacc tacaacaacc acctctacaa gcaaatctcc      120

agccaatcgg gtgccaccaa cgacaaccac tacttcggct acagcacccc ttgggggtat      180

tttgatttca acagattcca ctgccatttc tcaccacgtg actggcagcg actcatcaac      240

aacaactggg gattc                                                       255


<210> 5102
<211> 2208
<212> DNA
<213> Adeno-associated virus 2

<400> 5102
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 5103
<211> 735
<212> PRT
<213> Adeno-associated virus 2

<400> 5103
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5104
<211> 621
<212> PRT
<213> Adeno-associated virus 2

<400> 5104
Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Gly His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
            580                 585                 590         


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
        595                 600                 605             


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620     


<210> 5105
<211> 4675
<212> DNA
<213> Adeno-associated virus 2

<400> 5105
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgtatt agaggtcacg tgagtgtttt gcgacatttt gcgacaccat      240

gtggtcacgc tgggtattta agcccgagtg agcacgcagg gtctccattt tgaagcggga      300

ggtttgaacg cgcagccgcc atgccggggt tttacgagat tgtgattaag gtccccagcg      360

accttgacgg gcatctgccc ggcatttctg acagctttgt gaactgggtg gccgagaagg      420

aatgggagtt gccgccagat tctgacatgg atctgaatct gattgagcag gcacccctga      480

ccgtggccga gaagctgcag cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc      540

cggaggccct tttctttgtg caatttgaga agggagagag ctacttccac atgcacgtgc      600

tcgtggaaac caccggggtg aaatccatgg ttttgggacg tttcctgagt cagattcgcg      660

aaaaactgat tcagagaatt taccgcggga tcgagccgac tttgccaaac tggttcgcgg      720

tcacaaagac cagaaatggc gccggaggcg ggaacaaggt ggtggatgag tgctacatcc      780

ccaattactt gctccccaaa acccagcctg agctccagtg ggcgtggact aatatggaac      840

agtatttaag cgcctgtttg aatctcacgg agcgtaaacg gttggtggcg cagcatctga      900

cgcacgtgtc gcagacgcag gagcagaaca aagagaatca gaatcccaat tctgatgcgc      960

cggtgatcag atcaaaaact tcagccaggt acatggagct ggtcgggtgg ctcgtggaca     1020

aggggattac ctcggagaag cagtggatcc aggaggacca ggcctcatac atctccttca     1080

atgcggcctc caactcgcgg tcccaaatca aggctgcctt ggacaatgcg ggaaagatta     1140

tgagcctgac taaaaccgcc cccgactacc tggtgggcca gcagcccgtg gaggacattt     1200

ccagcaatcg gatttataaa attttggaac taaacgggta cgatccccaa tatgcggctt     1260

ccgtctttct gggatgggcc acgaaaaagt tcggcaagag gaacaccatc tggctgtttg     1320

ggcctgcaac taccgggaag accaacatcg cggaggccat agcccacact gtgcccttct     1380

acgggtgcgt aaactggacc aatgagaact ttcccttcaa cgactgtgtc gacaagatgg     1440

tgatctggtg ggaggagggg aagatgaccg ccaaggtcgt ggagtcggcc aaagccattc     1500

tcggaggaag caaggtgcgc gtggaccaga aatgcaagtc ctcggcccag atagacccga     1560

ctcccgtgat cgtcacctcc aacaccaaca tgtgcgccgt gattgacggg aactcaacga     1620

ccttcgaaca ccagcagccg ttgcaagacc ggatgttcaa atttgaactc acccgccgtc     1680

tggatcatga ctttgggaag gtcaccaagc aggaagtcaa agactttttc cggtgggcaa     1740

aggatcacgt ggttgaggtg gagcatgaat tctacgtcaa aaagggtgga gccaagaaaa     1800

gacccgcccc cagtgacgca gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc     1860

agccatcgac gtcagacgcg gaagcttcga tcaactacgc agacaggtac caaaacaaat     1920

gttctcgtca cgtgggcatg aatctgatgc tgtttccctg cagacaatgc gagagaatga     1980

atcagaattc aaatatctgc ttcactcacg gacagaaaga ctgtttagag tgctttcccg     2040

tgtcagaatc tcaacccgtt tctgtcgtca aaaaggcgta tcagaaactg tgctacattc     2100

atcatatcat gggaaaggtg ccagacgctt gcactgcctg cgatctggtc aatgtggatt     2160

tggatgactg catctttgaa caataaatga tttaaatcag gtatggctgc cgatggttat     2220

cttccagatt ggctcgagga cactctctct gaaggaataa gacagtggtg gaagctcaaa     2280

cctggcccac caccaccaaa gcccgcagag cggcataagg acgacagcag gggtcttgtg     2340

cttcctgggt acaagtacct cggacccttc aacggactcg acaagggaga gccggtcaac     2400

gaggcagacg ccgcggccct cgagcacgta caaagcctac gaccggcagc tcgacagcgg     2460

agacaacccg tacctcaagt acaaccacgc cgacgcggag tttcaggagc gccttaaaga     2520

agatacgtct tttgggggca acctcggacg agcagtcttc caggcgaaaa agagggttct     2580

tgaacctctg ggcctggttg aggaacctgt taagacggct ccgggaaaaa agaggccggt     2640

agagcactct cctgtggagc cagactcctc ctcgggaacc ggaaaggcgg gccagcagcc     2700

tgcaagaaaa agattgaatt ttggtcagac tggagacgca gactcagtac ctgaccccca     2760

gcctctcgga cagccaccag cagccccctc tggtctggga actaatacga tggctacagg     2820

cagtggcgca ccaatggcag acaataacga gggcgccgac ggagtgggta attcctccgg     2880

aaattggcat tgcgattcca catggatggg cgacagagtc atcaccacca gcacccgaac     2940

ctgggccctg cccacctaca acaaccacct ctacaaacaa atttccagcc aatcaggagc     3000

ctcgaacgac aatcactact ttggctacag caccccttgg gggtattttg acttcaacag     3060

attccactgc cacttttcac cacgtgactg gcaaagactc atcaacaaca actggggatt     3120

ccgacccaag agactcaact tcaagctctt taacattcaa gtcaaagagg tcacgcagaa     3180

tgacggtacg acgacgattg ccaataacct taccagcacg gttcaggtgt ttactgactc     3240

ggagtaccag ctcccgtacg tcctcggctc ggcgcatcaa ggatgcctcc cgccgttccc     3300

agcagacgtc ttcatggtgc cacagtatgg atacctcacc ctgaacaacg ggagtcaggc     3360

agtaggacgc tcttcatttt actgcctgga gtactttcct tctcagatgc tgcgtaccgg     3420

aaacaacttt accttcagct acacttttga ggacgttcct ttccacagca gctacgctca     3480

cagccagagt ctggaccgtc tcatgaatcc tctcatcgac cagtacctgt attacttgag     3540

cagaacaaac actccaagtg gaaccaccac gcagtcaagg cttcagtttt ctcaggccgg     3600

agcgagtgac attcgggacc agtctaggaa ctggcttcct ggaccctgtt accgccagca     3660

gcgagtatca aagacatctg cggataacaa caacagtgaa tactcgtgga ctggagctac     3720

caagtaccac ctcaatggca gagactctct ggtgaatccg gccatggcaa gccacaagga     3780

cgatgaagaa aagttttttc ctcagagcgg ggttctcatc tttgggaagc aaggctcaga     3840

gaaaacaaat gtgaacattg aaaaggtcat gattacagac gaagaggaaa tcggaacaac     3900

caatcccgtg gctacggagc agtatggttc tgtatctacc aacctccaga gaggcaacag     3960

acaagcagct accgcagatg tcaacacaca aggcgttctt ccaggcatgg tctggcagga     4020

cagagatgtg taccttcagg ggcccatctg ggcaaagatt ccacacacgg acggacattt     4080

tcacccctct cccctcatgg gtggattcgg acttaaacac cctcctccac agattctcat     4140

caagaacacc ccggtacctg cgaatccttc gaccaccttc agtgcggcaa agtttgcttc     4200

cttcatcaca cagtactcca cgggacacgg tcagcgtgga gatcgagtgg gagctgcaga     4260

aggaaaacag caaacgctgg aatcccgaaa ttcagtacac ttccaactac aacaagtctg     4320

ttaatcgtgg acttaccgtg gatactaatg gcgtgtattc agagcctcgc cccattggca     4380

ccagatacct gactcgtaat ctgtaattgc ttgttaatca ataaaccgtt taattcgttt     4440

cagttgaact ttggtctctg cgtatttctt tcttatctag tttccatggc tacgtagata     4500

agtagcatgg cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc     4560

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     4620

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg gccaa          4675


<210> 5106
<211> 4679
<212> DNA
<213> Adeno-associated virus 2

<400> 5106
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgtatt agaggtcacg tgagtgtttt gcgacatttt gcgacaccat      240

gtggtcacgc tgggtattta agcccgagtg agcacgcagg gtctccattt tgaagcggga      300

ggtttgaacg cgcagccgcc atgccggggt tttacgagat tgtgattaag gtccccagcg      360

accttgacgg gcatctgccc ggcatttctg acagctttgt gaactgggtg gccgagaagg      420

aatgggagtt gccgccagat tctgacatgg atctgaatct gattgagcag gcacccctga      480

ccgtggccga gaagctgcag cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc      540

cggaggccct tttctttgtg caatttgaga agggagagag ctacttccac atgcacgtgc      600

tcgtggaaac caccggggtg aaatccatgg ttttgggacg tttcctgagt cagattcgcg      660

aaaaactgat tcagagaatt taccgcggga tcgagccgac tttgccaaac tggttcgcgg      720

tcacaaagac cagaaatggc gccggaggcg ggaacaaggt ggtggatgag tgctacatcc      780

ccaattactt gctccccaaa acccagcctg agctccagtg ggcgtggact aatatggaac      840

agtatttaag cgcctgtttg aatctcacgg agcgtaaacg gttggtggcg cagcatctga      900

cgcacgtgtc gcagacgcag gagcagaaca aagagaatca gaatcccaat tctgatgcgc      960

cggtgatcag atcaaaaact tcagccaggt acatggagct ggtcgggtgg ctcgtggaca     1020

aggggattac ctcggagaag cagtggatcc aggaggacca ggcctcatac atctccttca     1080

atgcggcctc caactcgcgg tcccaaatca aggctgcctt ggacaatgcg ggaaagatta     1140

tgagcctgac taaaaccgcc cccgactacc tggtgggcca gcagcccgtg gaggacattt     1200

ccagcaatcg gatttataaa attttggaac taaacgggta cgatccccaa tatgcggctt     1260

ccgtctttct gggatgggcc acgaaaaagt tcggcaagag gaacaccatc tggctgtttg     1320

ggcctgcaac taccgggaag accaacatcg cggaggccat agcccacact gtgcccttct     1380

acgggtgcgt aaactggacc aatgagaact ttcccttcaa cgactgtgtc gacaagatgg     1440

tgatctggtg ggaggagggg aagatgaccg ccaaggtcgt ggagtcggcc aaagccattc     1500

tcggaggaag caaggtgcgc gtggaccaga aatgcaagtc ctcggcccag atagacccga     1560

ctcccgtgat cgtcacctcc aacaccaaca tgtgcgccgt gattgacggg aactcaacga     1620

ccttcgaaca ccagcagccg ttgcaagacc ggatgttcaa atttgaactc acccgccgtc     1680

tggatcatga ctttgggaag gtcaccaagc aggaagtcaa agactttttc cggtgggcaa     1740

aggatcacgt ggttgaggtg gagcatgaat tctacgtcaa aaagggtgga gccaagaaaa     1800

gacccgcccc cagtgacgca gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc     1860

agccatcgac gtcagacgcg gaagcttcga tcaactacgc agacaggtac caaaacaaat     1920

gttctcgtca cgtgggcatg aatctgatgc tgtttccctg cagacaatgc gagagaatga     1980

atcagaattc aaatatctgc ttcactcacg gacagaaaga ctgtttagag tgctttcccg     2040

tgtcagaatc tcaacccgtt tctgtcgtca aaaaggcgta tcagaaactg tgctacattc     2100

atcatatcat gggaaaggtg ccagacgctt gcactgcctg cgatctggtc aatgtggatt     2160

tggatgactg catctttgaa caataaatga tttaaatcag gtatggctgc cgatggttat     2220

cttccagatt ggctcgagga cactctctct gaaggaataa gacagtggtg gaagctcaaa     2280

cctggcccac caccaccaaa gcccgcagag cggcataagg acgacagcag gggtcttgtg     2340

cttcctgggt acaagtacct cggacccttc aacggactcg acaagggaga gccggtcaac     2400

gaggcagacg ccgcggccct cgagcacgac aaagcctacg accggcagct cgacagcgga     2460

gacaacccgt acctcaagta caaccacgcc gacgcggagt ttcaggagcg ccttaaagaa     2520

gatacgtctt ttgggggcaa cctcggacga gcagtcttcc aggcgaaaaa gagggttctt     2580

gaacctctgg gcctggttga ggaacctgtt aagacggctc cgggaaaaaa gaggccggta     2640

gagcactctc ctgtggagcc agactcctcc tcgggaaccg gaaaggcggg ccagcagcct     2700

gcaagaaaaa gattgaattt tggtcagact ggagacgcag actcagtacc tgacccccag     2760

cctctcggac agccaccagc agccccctct ggtctgggaa ctaatacgat ggctacaggc     2820

agtggcgcac caatggcaga caataacgag ggcgccgacg gagtgggtaa ttcctccgga     2880

aattggcatt gcgattccac atggatgggc gacagagtca tcaccaccag cacccgaacc     2940

tgggccctgc ccacctacaa caaccacctc tacaaacaaa tttccagcca atcaggagcc     3000

tcgaacgaca atcactactt tggctacagc accccttggg ggtattttga cttcaacaga     3060

ttccactgcc acttttcacc acgtgactgg caaagactca tcaacaacaa ctggggattc     3120

cgacccaaga gactcaactt caagctcttt aacattcaag tcaaagaggt cacgcagaat     3180

gacggtacga cgacgattgc caataacctt accagcacgg ttcaggtgtt tactgactcg     3240

gagtaccagc tcccgtacgt cctcggctcg gcgcatcaag gatgcctccc gccgttccca     3300

gcagacgtct tcatggtgcc acagtatgga tacctcaccc tgaacaacgg gagtcaggca     3360

gtaggacgct cttcatttta ctgcctggag tactttcctt ctcagatgct gcgtaccgga     3420

aacaacttta ccttcagcta cacttttgag gacgttcctt tccacagcag ctacgctcac     3480

agccagagtc tggaccgtct catgaatcct ctcatcgacc agtacctgta ttacttgagc     3540

agaacaaaca ctccaagtgg aaccaccacg cagtcaaggc ttcagttttc tcaggccgga     3600

gcgagtgaca ttcgggacca gtctaggaac tggcttcctg gaccctgtta ccgccagcag     3660

cgagtatcaa agacatctgc ggataacaac aacagtgaat actcgtggac tggagctacc     3720

aagtaccacc tcaatggcag agactctctg gtgaatccgg gcccggccat ggcaagccac     3780

aaggacgatg aagaaaagtt ttttcctcag agcggggttc tcatctttgg gaagcaaggc     3840

tcagagaaaa caaatgtgga cattgaaaag gtcatgatta cagacgaaga ggaaatcagg     3900

acaaccaatc ccgtggctac ggagcagtat ggttctgtat ctaccaacct ccagagaggc     3960

aacagacaag cagctaccgc agatgtcaac acacaaggcg ttcttccagg catggtctgg     4020

caggacagag atgtgtacct tcaggggccc atctgggcaa agattccaca cacggacgga     4080

cattttcacc cctctcccct catgggtgga ttcggactta aacaccctcc tccacagatt     4140

ctcatcaaga acaccccggt acctgcgaat ccttcgacca ccttcagtgc ggcaaagttt     4200

gcttccttca tcacacagta ctccacggga caggtcagcg tggagatcga gtgggagctg     4260

cagaaggaaa acagcaaacg ctggaatccc gaaattcagt acacttccaa ctacaacaag     4320

tctgttaatg tggactttac tgtggacact aatggcgtgt attcagagcc tcgccccatt     4380

ggcaccagat acctgactcg taatctgtaa ttgcttgtta atcaataaac cgtttaattc     4440

gtttcagttg aactttggtc tctgcgtatt tctttcttat ctagtttcca tggctacgta     4500

gataagtagc atggcgggtt aatcattaac tacaaggaac ccctagtgat ggagttggcc     4560

actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc     4620

ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcagagaggg agtggccaa      4679


<210> 5107
<211> 735
<212> PRT
<213> Adeno-associated virus 2

<400> 5107
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asp Lys Ala Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735 


<210> 5108
<211> 740
<212> PRT
<213> Adeno-associated virus 2

<400> 5108
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu Leu 
                725                 730                 735     


Leu Ala Ala Ala 
            740 


<210> 5109
<211> 734
<212> PRT
<213> Adeno-associated virus 2

<400> 5109
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Met Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Ile Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 


<210> 5110
<211> 734
<212> PRT
<213> Adeno-associated virus 2

<400> 5110
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Glu Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 


<210> 5111
<211> 739
<212> PRT
<213> Adeno-associated virus 2

<400> 5111
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu Leu 
                725                 730                 735     


Leu Ala Ala 
            


<210> 5112
<211> 725
<212> PRT
<213> Adeno-associated virus 2

<400> 5112
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro 
                725 


<210> 5113
<211> 707
<212> PRT
<213> Adeno-associated virus 2

<400> 5113
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Cys Ile Tyr Gln Pro Pro Glu Arg Gln Gln Thr Ser Ser Tyr 
            580                 585                 590         


Arg Arg Cys Gln His Thr Arg Arg Ser Ser Arg His Gly Leu Ala Gly 
        595                 600                 605             


Gln Arg Cys Val Pro Ser Gly Ala His Leu Gly Lys Asp Ser Thr His 
    610                 615                 620                 


Gly Arg Thr Phe Ser Pro Leu Ser Pro His Gly Trp Ile Arg Thr Thr 
625                 630                 635                 640 


Pro Ser Ser Thr Asp Ser His Gln Glu His Pro Gly Thr Cys Glu Ser 
                645                 650                 655     


Phe Asp His Leu Gln Cys Gly Lys Val Cys Phe Leu His His Thr Val 
            660                 665                 670         


Leu His Gly Thr Gly Gln Arg Gly Asp Arg Val Arg Ala Ala Glu Gly 
        675                 680                 685             


Lys Gln Gln Thr Leu Glu Ser Arg Asn Ser Val His Phe Gln Leu Gln 
    690                 695                 700                 


Gln Val Cys 
705         


<210> 5114
<211> 739
<212> PRT
<213> Adeno-associated virus 2

<400> 5114
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu Leu 
                725                 730                 735     


Leu Ala Ala 
            


<210> 5115
<211> 737
<212> PRT
<213> Adeno-associated virus 2

<400> 5115
Met Ala Ser Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser 
    450                 455                 460                 


Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn 
                485                 490                 495     


Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala 
            580                 585                 590         


Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His His Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


Leu 
    


<210> 5116
<211> 741
<212> PRT
<213> Adeno-associated virus 2

<400> 5116
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Leu Ala Asn His Asn 
            580                 585                 590         


Asn Thr Thr Asn Ala Arg Gln Ala Ala Thr Ala Asp Val Asn Thr Gln 
        595                 600                 605             


Gly Val Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln 
    610                 615                 620                 


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro 
625                 630                 635                 640 


Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile 
                645                 650                 655     


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ser Thr Thr Phe Ser 
            660                 665                 670         


Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
        675                 680                 685             


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
    690                 695                 700                 


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Ile Asn Val 
705                 710                 715                 720 


Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Pro Ile 
                725                 730                 735     


Gly Thr Arg Tyr Leu 
            740     


<210> 5117
<211> 730
<212> PRT
<213> Adeno-associated virus 2

<400> 5117
Met Ala Ser Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Asn Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg 
                725                 730 


<210> 5118
<211> 735
<212> PRT
<213> Adeno-associated virus 2


<220>
<221> MOD_RES
<222> (239)..(239)
<223> Any amino acid

<400> 5118
Met Ala Ser Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Xaa Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Asn Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735 


<210> 5119
<211> 733
<212> PRT
<213> Adeno-associated virus 2

<400> 5119
Met Ala Ser Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Leu Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Asn Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr 
                725                 730             


<210> 5120
<211> 734
<212> PRT
<213> Adeno-associated virus 2

<400> 5120
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Cys Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Asn Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Asn Gln Ser Gly Ser Ala Gln Asn Asn Asp Leu Leu Phe Ser Arg 
    450                 455                 460                 


Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn Gly 
            500                 505                 510         


Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly Lys 
    530                 535                 540                 


Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg Phe 
                565                 570                 575     


Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala Thr 
            580                 585                 590         


Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu Tyr 
705                 710                 715                 720 


Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 


<210> 5121
<211> 734
<212> PRT
<213> Adeno-associated virus 2

<400> 5121
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Ser Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Ile Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 


<210> 5122
<211> 738
<212> PRT
<213> Adeno-associated virus 2

<400> 5122
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Gly Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu Leu 
                725                 730                 735     


Arg Pro 
        


<210> 5123
<211> 736
<212> PRT
<213> Adeno-associated virus 3

<400> 5123
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Gly 
    130                 135                 140                 


Ala Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Arg Gly Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5124
<211> 4726
<212> DNA
<213> Adeno-associated virus 3

<400> 5124
ttggccactc cctctatgcg cactcgctcg ctcggtgggg cctggcgacc aaaggtcgcc       60

agacggacgt gctttgcacg tccggcccca ccgagcgagc gagtgcgcat agagggagtg      120

gccaactcca tcactagagg tatggcagtg acgtaacgcg aagcgcgcga agcgagacca      180

cgcctaccag ctgcgtcagc agtcaggtga cccttttgcg acagtttgcg acaccacgtg      240

gccgctgagg gtatatattc tcgagtgagc gaaccaggag ctccattttg accgcgaaat      300

ttgaacgagc agcagccatg ccggggttct acgagattgt cctgaaggtc ccgagtgacc      360

tggacgagcg cctgccgggc atttctaact cgtttgttaa ctgggtggcc gagaaggaat      420

gggacgtgcc gccggattct gacatggatc cgaatctgat tgagcaggca cccctgaccg      480

tggccgaaaa gcttcagcgc gagttcctgg tggagtggcg ccgcgtgagt aaggccccgg      540

aggccctctt ttttgtccag ttcgaaaagg gggagaccta cttccacctg cacgtgctga      600

ttgagaccat cggggtcaaa tccatggtgg tcggccgcta cgtgagccag attaaagaga      660

agctggtgac ccgcatctac cgcggggtcg agccgcagct tccgaactgg ttcgcggtga      720

ccaaaacgcg aaatggcgcc gggggcggga acaaggtggt ggacgactgc tacatcccca      780

actacctgct ccccaagacc cagcccgagc tccagtgggc gtggactaac atggaccagt      840

atttaagcgc ctgtttgaat ctcgcggagc gtaaacggct ggtggcgcag catctgacgc      900

acgtgtcgca gacgcaggag cagaacaaag agaatcagaa ccccaattct gacgcgccgg      960

tcatcaggtc aaaaacctca gccaggtaca tggagctggt cgggtggctg gtggaccgcg     1020

ggatcacgtc agaaaagcaa tggattcagg aggaccaggc ctcgtacatc tccttcaacg     1080

ccgcctccaa ctcgcggtcc cagatcaagg ccgcgctgga caatgcctcc aagatcatga     1140

gcctgacaaa gacggctccg gactacctgg tgggcagcaa cccgccggag gacattacca     1200

aaaatcggat ctaccaaatc ctggagctga acgggtacga tccgcagtac gcggcctccg     1260

tcttcctggg ctgggcgcaa aagaagttcg ggaagaggaa caccatctgg ctctttgggc     1320

cggccacgac gggtaaaacc aacatcgcgg aagccatcgc ccacgccgtg cccttctacg     1380

gctgcgtaaa ctggaccaat gagaactttc ccttcaacga ttgcgtcgac aagatggtga     1440

tctggtggga ggagggcaag atgacggcca aggtcgtgga gagcgccaag gccattctgg     1500

gcggaagcaa ggtgcgcgtg gaccaaaagt gcaagtcatc ggcccagatc gaacccactc     1560

ccgtgatcgt cacctccaac accaacatgt gcgccgtgat tgacgggaac agcaccacct     1620

tcgagcatca gcagccgctg caggaccgga tgtttgaatt tgaacttacc cgccgtttgg     1680

accatgactt tgggaaggtc accaaacagg aagtaaagga ctttttccgg tgggcttccg     1740

atcacgtgac tgacgtggct catgagttct acgtcagaaa gggtggagct aagaaacgcc     1800

ccgcctccaa tgacgcggat gtaagcgagc caaaacggga gtgcacgtca cttgcgcagc     1860

cgacaacgtc agacgcggaa gcaccggcgg actacgcgga caggtaccaa aacaaatgtt     1920

ctcgtcacgt gggcatgaat ctgatgcttt ttccctgtaa aacatgcgag agaatgaatc     1980

aaatttccaa tgtctgtttt acgcatggtc aaagagactg tggggaatgc ttccctggaa     2040

tgtcagaatc tcaacccgtt tctgtcgtca aaaagaagac ttatcagaaa ctgtgtccaa     2100

ttcatcatat cctgggaagg gcacccgaga ttgcctgttc ggcctgcgat ttggccaatg     2160

tggacttgga tgactgtgtt tctgagcaat aaatgactta aaccaggtat ggctgctgac     2220

ggttatcttc cagattggct cgaggacaac ctttctgaag gcattcgtga gtggtgggct     2280

ctgaaacctg gagtccctca acccaaagcg aaccaacaac accaggacaa ccgtcggggt     2340

cttgtgcttc cgggttacaa atacctcgga cccggtaacg gactcgacaa aggagagccg     2400

gtcaacgagg cggacgcggc agccctcgaa cacgacaaag cttacgacca gcagctcaag     2460

gccggtgaca acccgtacct caagtacaac cacgccgacg ccgagtttca ggagcgtctt     2520

caagaagata cgtcttttgg gggcaacctt ggcagagcag tcttccaggc caaaaagagg     2580

atccttgagc ctcttggtct ggttgaggaa gcagctaaaa cggctcctgg aaagaagggg     2640

gctgtagatc agtctcctca ggaaccggac tcatcatctg gtgttggcaa atcgggcaaa     2700

cagcctgcca gaaaaagact aaatttcggt cagactggag actcagagtc agtcccagac     2760

cctcaacctc tcggagaacc accagcagcc cccacaagtt tgggatctaa tacaatggct     2820

tcaggcggtg gcgcaccaat ggcagacaat aacgagggtg ccgatggagt gggtaattcc     2880

tcaggaaatt ggcattgcga ttcccaatgg ctgggcgaca gagtcatcac caccagcacc     2940

agaacctggg ccctgcccac ttacaacaac catctctaca agcaaatctc cagccaatca     3000

ggagcttcaa acgacaacca ctactttggc tacagcaccc cttgggggta ttttgacttt     3060

aacagattcc actgccactt ctcaccacgt gactggcagc gactcattaa caacaactgg     3120

ggattccggc ccaagaaact cagcttcaag ctcttcaaca tccaagttag aggggtcacg     3180

cagaacgatg gcacgacgac tattgccaat aaccttacca gcacggttca agtgtttacg     3240

gactcggagt atcagctccc gtacgtgctc gggtcggcgc accaaggctg tctcccgccg     3300

tttccagcgg acgtcttcat ggtccctcag tatggatacc tcaccctgaa caacggaagt     3360

caagcggtgg gacgctcatc cttttactgc ctggagtact tcccttcgca gatgctaagg     3420

actggaaata acttccaatt cagctatacc ttcgaggatg taccttttca cagcagctac     3480

gctcacagcc agagtttgga tcgcttgatg aatcctctta ttgatcagta tctgtactac     3540

ctgaacagaa cgcaaggaac aacctctgga acaaccaacc aatcacggct gctttttagc     3600

caggctgggc ctcagtctat gtctttgcag gccagaaatt ggctacctgg gccctgctac     3660

cggcaacaga gactttcaaa gactgctaac gacaacaaca acagtaactt tccttggaca     3720

gcggccagca aatatcatct caatggccgc gactcgctgg tgaatccagg accagctatg     3780

gccagtcaca aggacgatga agaaaaattt ttccctatgc acggcaatct aatatttggc     3840

aaagaaggga caacggcaag taacgcagaa ttagataatg taatgattac ggatgaagaa     3900

gagattcgta ccaccaatcc tgtggcaaca gagcagtatg gaactgtggc aaataacttg     3960

cagagctcaa atacagctcc cacgactgga actgtcaatc atcagggggc cttacctggc     4020

atggtgtggc aagatcgtga cgtgtacctt caaggaccta tctgggcaaa gattcctcac     4080

acggatggac actttcatcc ttctcctctg atgggaggct ttggactgaa acatccgcct     4140

cctcaaatca tgatcaaaaa tactccggta ccggcaaatc ctccgacgac tttcagcccg     4200

gccaagtttg cttcatttat cactcagtac tccactggac aggtcagcgt ggaaattgag     4260

tgggagctac agaaagaaaa cagcaaacgt tggaatccag agattcagta cacttccaac     4320

tacaacaagt ctgttaatgt ggactttact gtagacacta atggtgttta tagtgaacct     4380

cgccctattg gaacccggta tctcacacga aacttgtgaa tcctggttaa tcaataaacc     4440

gtttaattcg tttcagttga actttggctc ttgtgcactt ctttatcttt atcttgtttc     4500

catggctact gcgtagataa gcagcggcct gcggcgcttg cgcttcgcgg tttacaactg     4560

ctggttaata tttaactctc gccatacctc tagtgatgga gttggccact ccctctatgc     4620

gcactcgctc gctcggtggg gcctggcgac caaaggtcgc cagacggacg tgctttgcac     4680

gtccggcccc accgagcgag cgagtgcgca tagagggagt ggccaa                    4726


<210> 5125
<211> 736
<212> PRT
<213> Adeno-associated virus 3A

<400> 5125
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Gly 
    130                 135                 140                 


Ala Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Arg Gly Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5126
<211> 624
<212> PRT
<213> Adeno-associated virus 3A

<400> 5126
Met Pro Gly Phe Tyr Glu Ile Val Leu Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu Arg Leu Pro Gly Ile Ser Asn Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Asp Val Pro Pro Asp Ser Asp Met Asp Pro Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Glu Phe Leu 
    50                  55                  60                  


Val Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Thr Tyr Phe His Leu His Val Leu Ile Glu 
                85                  90                  95      


Thr Ile Gly Val Lys Ser Met Val Val Gly Arg Tyr Val Ser Gln Ile 
            100                 105                 110         


Lys Glu Lys Leu Val Thr Arg Ile Tyr Arg Gly Val Glu Pro Gln Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Asp Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Asp Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Ser Asn 
        275                 280                 285             


Pro Pro Glu Asp Ile Thr Lys Asn Arg Ile Tyr Gln Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Glu Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Glu Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Asp Val 
465                 470                 475                 480 


Ala His Glu Phe Tyr Val Arg Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Ser Asn Asp Ala Asp Val Ser Glu Pro Lys Arg Glu Cys Thr Ser Leu 
            500                 505                 510         


Ala Gln Pro Thr Thr Ser Asp Ala Glu Ala Pro Ala Asp Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Lys Thr Cys Glu Arg Met Asn Gln Ile Ser Asn Val Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Arg Asp Cys Gly Glu Cys Phe Pro Gly Met Ser 
                565                 570                 575     


Glu Ser Gln Pro Val Ser Val Val Lys Lys Lys Thr Tyr Gln Lys Leu 
            580                 585                 590         


Cys Pro Ile His His Ile Leu Gly Arg Ala Pro Glu Ile Ala Cys Ser 
        595                 600                 605             


Ala Cys Asp Leu Ala Asn Val Asp Leu Asp Asp Cys Val Ser Glu Gln 
    610                 615                 620                 


<210> 5127
<211> 736
<212> PRT
<213> Adeno-associated virus 3B

<400> 5127
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5128
<211> 624
<212> PRT
<213> Adeno-associated virus 3B

<400> 5128
Met Pro Gly Phe Tyr Glu Ile Val Leu Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asn Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Pro Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Glu Phe Leu 
    50                  55                  60                  


Val Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Thr Tyr Phe His Leu His Val Leu Ile Glu 
                85                  90                  95      


Thr Ile Gly Val Lys Ser Met Val Val Gly Arg Tyr Val Ser Gln Ile 
            100                 105                 110         


Lys Glu Lys Leu Val Thr Arg Ile Tyr Arg Gly Val Glu Pro Gln Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Asp Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Asp Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Ser Asn 
        275                 280                 285             


Pro Pro Glu Asp Ile Thr Lys Asn Arg Ile Tyr Gln Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Glu Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Asp Val 
465                 470                 475                 480 


Ala His Glu Phe Tyr Val Arg Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Ser Asn Asp Ala Asp Val Ser Glu Pro Lys Arg Gln Cys Thr Ser Leu 
            500                 505                 510         


Ala Gln Pro Thr Thr Ser Asp Ala Glu Ala Pro Ala Asp Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Lys Thr Cys Glu Arg Met Asn Gln Ile Ser Asn Val Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Arg Asp Cys Gly Glu Cys Phe Pro Gly Met Ser 
                565                 570                 575     


Glu Ser Gln Pro Val Ser Val Val Lys Lys Lys Thr Tyr Gln Lys Leu 
            580                 585                 590         


Cys Pro Ile His His Ile Leu Gly Arg Ala Pro Glu Ile Ala Cys Ser 
        595                 600                 605             


Ala Cys Asp Leu Ala Asn Val Asp Leu Asp Asp Cys Val Ser Glu Gln 
    610                 615                 620                 


<210> 5129
<211> 4722
<212> DNA
<213> Adeno-associated virus 3B

<400> 5129
tggccactcc ctctatgcgc actcgctcgc tcggtggggc ctggcgacca aaggtcgcca       60

gacggacgtg ctttgcacgt ccggccccac cgagcgagcg agtgcgcata gagggagtgg      120

ccaactccat cactagaggt atggcagtga cgtaacgcga agcgcgcgaa gcgagaccac      180

gcctaccagc tgcgtcagca gtcaggtgac ccttttgcga cagtttgcga caccacgtgg      240

ccgctgaggg tatatattct cgagtgagcg aaccaggagc tccattttga ccgcgaaatt      300

tgaacgagca gcagccatgc cggggttcta cgagattgtc ctgaaggtcc cgagtgacct      360

ggacgagcac ctgccgggca tttctaactc gtttgttaac tgggtggccg agaaggaatg      420

ggagctgccg ccggattctg acatggatcc gaatctgatt gagcaggcac ccctgaccgt      480

ggccgaaaag cttcagcgcg agttcctggt ggagtggcgc cgcgtgagta aggccccgga      540

ggccctcttt tttgtccagt tcgaaaaggg ggagacctac ttccacctgc acgtgctgat      600

tgagaccatc ggggtcaaat ccatggtggt cggccgctac gtgagccaga ttaaagagaa      660

gctggtgacc cgcatctacc gcggggtcga gccgcagctt ccgaactggt tcgcggtgac      720

caaaacgcga aatggcgccg ggggcgggaa caaggtggtg gacgactgct acatccccaa      780

ctacctgctc cccaagaccc agcccgagct ccagtgggcg tggactaaca tggaccagta      840

tttaagcgcc tgtttgaatc tcgcggagcg taaacggctg gtggcgcagc atctgacgca      900

cgtgtcgcag acgcaggagc agaacaaaga gaatcagaac cccaattctg acgcgccggt      960

catcaggtca aaaacctcag ccaggtacat ggagctggtc gggtggctgg tggaccgcgg     1020

gatcacgtca gaaaagcaat ggattcagga ggaccaggcc tcgtacatct ccttcaacgc     1080

cgcctccaac tcgcggtccc agatcaaggc cgcgctggac aatgcctcca agatcatgag     1140

cctgacaaag acggctccgg actacctggt gggcagcaac ccgccggagg acattaccaa     1200

aaatcggatc taccaaatcc tggagctgaa cgggtacgat ccgcagtacg cggcctccgt     1260

cttcctgggc tgggcgcaaa agaagttcgg gaagaggaac accatctggc tctttgggcc     1320

ggccacgacg ggtaaaacca acatcgcgga agccatcgcc cacgccgtgc ccttctacgg     1380

ctgcgtaaac tggaccaatg agaactttcc cttcaacgat tgcgtcgaca agatggtgat     1440

ctggtgggag gagggcaaga tgacggccaa ggtcgtggag agcgccaagg ccattctggg     1500

cggaagcaag gtgcgcgtgg accaaaagtg caagtcatcg gcccagatcg aacccactcc     1560

cgtgatcgtc acctccaaca ccaacatgtg cgccgtgatt gacgggaaca gcaccacctt     1620

cgagcatcag cagccgctgc aggaccggat gtttaaattt gaacttaccc gccgtttgga     1680

ccatgacttt gggaaggtca ccaaacagga agtaaaggac tttttccggt gggcttccga     1740

tcacgtgact gacgtggctc atgagttcta cgtcagaaag ggtggagcta agaaacgccc     1800

cgcctccaat gacgcggatg taagcgagcc aaaacggcag tgcacgtcac ttgcgcagcc     1860

gacaacgtca gacgcggaag caccggcgga ctacgcggac aggtaccaaa acaaatgttc     1920

tcgtcacgtg ggcatgaatc tgatgctttt tccctgtaaa acatgcgaga gaatgaatca     1980

aatttccaat gtctgtttta cgcatggtca aagagactgt ggggaatgct tccctggaat     2040

gtcagaatct caacccgttt ctgtcgtcaa aaagaagact tatcagaaac tgtgtccaat     2100

tcatcatatc ctgggaaggg cacccgagat tgcctgttcg gcctgcgatt tggccaatgt     2160

ggacttggat gactgtgttt ctgagcaata aatgacttaa accaggtatg gctgctgacg     2220

gttatcttcc agattggctc gaggacaacc tttctgaagg cattcgtgag tggtgggctc     2280

tgaaacctgg agtccctcaa cccaaagcga accaacaaca ccaggacaac cgtcggggtc     2340

ttgtgcttcc gggttacaaa tacctcggac ccggtaacgg actcgacaaa ggagagccgg     2400

tcaacgaggc ggacgcggca gccctcgaac acgacaaagc ttacgaccag cagctcaagg     2460

ccggtgacaa cccgtacctc aagtacaacc acgccgacgc cgagtttcag gagcgtcttc     2520

aagaagatac gtcttttggg ggcaaccttg gcagagcagt cttccaggcc aaaaagagga     2580

tccttgagcc tcttggtctg gttgaggaag cagctaaaac ggctcctgga aagaagaggc     2640

ctgtagatca gtctcctcag gaaccggact catcatctgg tgttggcaaa tcgggcaaac     2700

agcctgccag aaaaagacta aatttcggtc agactggcga ctcagagtca gtcccagacc     2760

ctcaacctct cggagaacca ccagcagccc ccacaagttt gggatctaat acaatggctt     2820

caggcggtgg cgcaccaatg gcagacaata acgagggtgc cgatggagtg ggtaattcct     2880

caggaaattg gcattgcgat tcccaatggc tgggcgacag agtcatcacc accagcacca     2940

gaacctgggc cctgcccact tacaacaacc atctctacaa gcaaatctcc agccaatcag     3000

gagcttcaaa cgacaaccac tactttggct acagcacccc ttgggggtat tttgacttta     3060

acagattcca ctgccacttc tcaccacgtg actggcagcg actcattaac aacaactggg     3120

gattccggcc caagaaactc agcttcaagc tcttcaacat ccaagttaaa gaggtcacgc     3180

agaacgatgg cacgacgact attgccaata accttaccag cacggttcaa gtgtttacgg     3240

actcggagta tcagctcccg tacgtgctcg ggtcggcgca ccaaggctgt ctcccgccgt     3300

ttccagcgga cgtcttcatg gtccctcagt atggatacct caccctgaac aacggaagtc     3360

aagcggtggg acgctcatcc ttttactgcc tggagtactt cccttcgcag atgctaagga     3420

ctggaaataa cttccaattc agctatacct tcgaggatgt accttttcac agcagctacg     3480

ctcacagcca gagtttggat cgcttgatga atcctcttat tgatcagtat ctgtactacc     3540

tgaacagaac gcaaggaaca acctctggaa caaccaacca atcacggctg ctttttagcc     3600

aggctgggcc tcagtctatg tctttgcagg ccagaaattg gctacctggg ccctgctacc     3660

ggcaacagag actttcaaag actgctaacg acaacaacaa cagtaacttt ccttggacag     3720

cggccagcaa atatcatctc aatggccgcg actcgctggt gaatccagga ccagctatgg     3780

ccagtcacaa ggacgatgaa gaaaaatttt tccctatgca cggcaatcta atatttggca     3840

aagaagggac aacggcaagt aacgcagaat tagataatgt aatgattacg gatgaagaag     3900

agattcgtac caccaatcct gtggcaacag agcagtatgg aactgtggca aataacttgc     3960

agagctcaaa tacagctccc acgactagaa ctgtcaatga tcagggggcc ttacctggca     4020

tggtgtggca agatcgtgac gtgtaccttc aaggacctat ctgggcaaag attcctcaca     4080

cggatggaca ctttcatcct tctcctctga tgggaggctt tggactgaaa catccgcctc     4140

ctcaaatcat gatcaaaaat actccggtac cggcaaatcc tccgacgact ttcagcccgg     4200

ccaagtttgc ttcatttatc actcagtact ccactggaca ggtcagcgtg gaaattgagt     4260

gggagctaca gaaagaaaac agcaaacgtt ggaatccaga gattcagtac acttccaact     4320

acaacaagtc tgttaatgtg gactttactg tagacactaa tggtgtttat agtgaacctc     4380

gccctattgg aacccggtat ctcacacgaa acttgtaatc ctggttaatc aataaaccgt     4440

ttaattcgtt tcagttgaac tttggctctt gtgcacttct tatcttatct tgtttccatg     4500

gctactgcgt agataagcag cggcctgcgg cgcttgcgct tcgcggttta caactgctgg     4560

ttaatattta actctcgcca tacctctagt gatggagttg gccactccct ctatgcgcac     4620

tcgctcgctc ggtggggccg gacgtgcaaa gcacgtccgt ctggcgacct ttggtcgcca     4680

ggccccaccg agcgagcgag tgcgcataga gggagtggcc aa                        4722


<210> 5130
<211> 1800
<212> DNA
<213> Adeno-associated virus 4


<220>
<221> modified_base
<222> (342)..(342)
<223> a, c, t or g

<400> 5130
acggctcctg gaaagaagag accgttgatt gaatcccccc agcagcccga ctcctccacg       60

ggtatcggca aaaaaggcaa gcagccggct aaaaagaagc tcgttttcga agacgaaact      120

ggagcaggcg acggaccccc tgagggatca acttccggag ccatgtctga tgacagtgag      180

atgcgtgcag cagctggcgg agctgcagtc gagggsggac aaggtgccga tggagtgggt      240

aatgcctcgg gtgattggca ttgcgattcc acctggtctg agggccacgt cacgaccacc      300

agcaccagaa cctgggtctt gcccacctac aacaaccacc tntacaagcg actcggagag      360

agcctgcagt ccaacaccta caacggattc tccaccccct ggggatactt tgacttcaac      420

cgcttccact gccacttctc accacgtgac tggcagcgac tcatcaacaa caactggggc      480

atgcgaccca aagccatgcg ggtcaaaatc ttcaacatcc aggtcaagga ggtcacgacg      540

tcgaacggcg agacaacggt ggctaataac cttaccagca cggttcagat ctttgcggac      600

tcgtcgtacg aactgccgta cgtgatggat gcgggtcaag agggcagcct gcctcctttt      660

cccaacgacg tctttatggt gccccagtac ggctactgtg gactggtgac cggcaacact      720

tcgcagcaac agactgacag aaatgccttc tactgcctgg agtactttcc ttcgcagatg      780

ctgcggactg gcaacaactt tgaaattacg tacagttttg agaaggtgcc tttccactcg      840

atgtacgcgc acagccagag cctggaccgg ctgatgaacc ctctcatcga ccagtacctg      900

tggggactgc aatcgaccac caccggaacc accctgaatg ccgggactgc caccaccaac      960

tttaccaagc tgcggcctac caacttttcc aactttaaaa agaactggct gcccgggcct     1020

tcaatcaagc agcagggctt ctcaaagact gccaatcaaa actacaagat ccctgccacc     1080

gggtcagaca gtctcatcaa atacgagacg cacagcactc tggacggaag atggagtgcc     1140

ctgacccccg gacctccaat ggccacggct ggacctgcgg acagcaagtt cagcaacagc     1200

cagctcatct ttgcggggcc taaacagaac ggcaacacgg ccaccgtacc cgggactctg     1260

atcttcacct ctgaggagga gctggcagcc accaacgcca ccgatacgga catgtggggc     1320

aacctacctg gcggtgacca gagcaacagc aacctgccga ccgtggacag actgacagcc     1380

ttgggagccg tgcctggaat ggtctggcaa aacagagaca tttactacca gggtcccatt     1440

tgggccaaga ttcctcatac cgatggacac tttcacccct caccgctgat tggtgggttt     1500

gggctgaaac acccgcctcc tcaaattttt atcaagaaca ccccggtacc tgcgaatcct     1560

gcaacgacct tcagctctac tccggtaaac tccttcatta ctcagtacag cactggccag     1620

gtgtcggtgc agattgactg ggagatccag aaggagcggt ccaaacgctg gaaccccgag     1680

gtccagttta cctccaacta cggacagcaa aactctctgt tgtgggctcc cgatgcggct     1740

gggaaataca ctgagcctag ggctatcggt acccgctacc tcacccacca cctgtaataa     1800


<210> 5131
<211> 2208
<212> DNA
<213> Adeno-associated virus 4


<220>
<221> modified_base
<222> (750)..(750)
<223> a, c, t or g

<400> 5131
atgactgacg gttaccttcc agattggcta gaggacaacc tctctgaagg cgttcgagag       60

tggtgggcgc tgcaacctgg agcccctaaa cccaaggcaa atcaacaaca tcaggacaac      120

gctcggggtc ttgtgcttcc gggttacaaa tacctcggac ccggcaacgg actcgacaag      180

ggggaacccg tcaacgcagc ggacgcggca gccctcgagc acgacaaggc ctacgaccag      240

cagctcaagg ccggtgacaa cccctacctc aagtacaacc acgccgacgc ggagttccag      300

cagcggcttc agggcgacac atcgtttggg ggcaacctcg gcagagcagt cttccaggcc      360

aaaaagaggg ttcttgaacc tcttggtctg gttgagcaag cgggtgagac ggctcctgga      420

aagaagagac cgttgattga atccccccag cagcccgact cctccacggg tatcggcaaa      480

aaaggcaagc agccggctaa aaagaagctc gttttcgaag acgaaactgg agcaggcgac      540

ggaccccctg agggatcaac ttccggagcc atgtctgatg acagtgagat gcgtgcagca      600

gctggcggag ctgcagtcga gggsggacaa ggtgccgatg gagtgggtaa tgcctcgggt      660

gattggcatt gcgattccac ctggtctgag ggccacgtca cgaccaccag caccagaacc      720

tgggtcttgc ccacctacaa caaccacctn tacaagcgac tcggagagag cctgcagtcc      780

aacacctaca acggattctc caccccctgg ggatactttg acttcaaccg cttccactgc      840

cacttctcac cacgtgactg gcagcgactc atcaacaaca actggggcat gcgacccaaa      900

gccatgcggg tcaaaatctt caacatccag gtcaaggagg tcacgacgtc gaacggcgag      960

acaacggtgg ctaataacct taccagcacg gttcagatct ttgcggactc gtcgtacgaa     1020

ctgccgtacg tgatggatgc gggtcaagag ggcagcctgc ctccttttcc caacgacgtc     1080

tttatggtgc cccagtacgg ctactgtgga ctggtgaccg gcaacacttc gcagcaacag     1140

actgacagaa atgccttcta ctgcctggag tactttcctt cgcagatgct gcggactggc     1200

aacaactttg aaattacgta cagttttgag aaggtgcctt tccactcgat gtacgcgcac     1260

agccagagcc tggaccggct gatgaaccct ctcatcgacc agtacctgtg gggactgcaa     1320

tcgaccacca ccggaaccac cctgaatgcc gggactgcca ccaccaactt taccaagctg     1380

cggcctacca acttttccaa ctttaaaaag aactggctgc ccgggccttc aatcaagcag     1440

cagggcttct caaagactgc caatcaaaac tacaagatcc ctgccaccgg gtcagacagt     1500

ctcatcaaat acgagacgca cagcactctg gacggaagat ggagtgccct gacccccgga     1560

cctccaatgg ccacggctgg acctgcggac agcaagttca gcaacagcca gctcatcttt     1620

gcggggccta aacagaacgg caacacggcc accgtacccg ggactctgat cttcacctct     1680

gaggaggagc tggcagccac caacgccacc gatacggaca tgtggggcaa cctacctggc     1740

ggtgaccaga gcaacagcaa cctgccgacc gtggacagac tgacagcctt gggagccgtg     1800

cctggaatgg tctggcaaaa cagagacatt tactaccagg gtcccatttg ggccaagatt     1860

cctcataccg atggacactt tcacccctca ccgctgattg gtgggtttgg gctgaaacac     1920

ccgcctcctc aaatttttat caagaacacc ccggtacctg cgaatcctgc aacgaccttc     1980

agctctactc cggtaaactc cttcattact cagtacagca ctggccaggt gtcggtgcag     2040

attgactggg agatccagaa ggagcggtcc aaacgctgga accccgaggt ccagtttacc     2100

tccaactacg gacagcaaaa ctctctgttg tgggctcccg atgcggctgg gaaatacact     2160

gagcctaggg ctatcggtac ccgctacctc acccaccacc tgtaataa                  2208


<210> 5132
<211> 1872
<212> DNA
<213> Adeno-associated virus 4

<400> 5132
atgccggggt tctacgagat cgtgctgaag gtgcccagcg acctggacga gcacctgccc       60

ggcatttctg actcttttgt gagctgggtg gccgagaagg aatgggagct gccgccggat      120

tctgacatgg acttgaatct gattgagcag gcacccctga ccgtggccga aaagctgcaa      180

cgcgagttcc tggtcgagtg gcgccgcgtg agtaaggccc cggaggccct cttctttgtc      240

cagttcgaga agggggacag ctacttccac ctgcacatcc tggtggagac cgtgggcgtc      300

aaatccatgg tggtgggccg ctacgtgagc cagattaaag agaagctggt gacccgcatc      360

taccgcgggg tcgagccgca gcttccgaac tggttcgcgg tgaccaagac gcgtaatggc      420

gccggaggcg ggaacaaggt ggtggacgac tgctacatcc ccaactacct gctccccaag      480

acccagcccg agctccagtg ggcgtggact aacatggacc agtatataag cgcctgtttg      540

aatctcgcgg agcgtaaacg gctggtggcg cagcatctga cgcacgtgtc gcagacgcag      600

gagcagaaca aggaaaacca gaaccccaat tctgacgcgc cggtcatcag gtcaaaaacc      660

tccgccaggt acatggagct ggtcgggtgg ctggtggacc gcgggatcac gtcagaaaag      720

caatggatcc aggaggacca ggcgtcctac atctccttca acgccgcctc caactcgcgg      780

tcacaaatca aggccgcgct ggacaatgcc tccaaaatca tgagcctgac aaagacggct      840

ccggactacc tggtgggcca gaacccgccg gaggacattt ccagcaaccg catctaccga      900

atcctcgaga tgaacgggta cgatccgcag tacgcggcct ccgtcttcct gggctgggcg      960

caaaagaagt tcgggaagag gaacaccatc tggctctttg ggccggccac gacgggtaaa     1020

accaacatcg cggaagccat cgcccacgcc gtgcccttct acggctgcgt gaactggacc     1080

aatgagaact ttccgttcaa cgattgcgtc gacaagatgg tgatctggtg ggaggagggc     1140

aagatgacgg ccaaggtcgt agagagcgcc aaggccatcc tgggcggaag caaggtgcgc     1200

gtggaccaaa agtgcaagtc atcggcccag atcgacccaa ctcccgtgat cgtcacctcc     1260

aacaccaaca tgtgcgcggt catcgacgga aactcgacca ccttcgagca ccaacaacca     1320

ctccaggacc ggatgttcaa gttcgagctc accaagcgcc tggagcacga ctttggcaag     1380

gtcaccaagc aggaagtcaa agactttttc cggtgggcgt cagatcacgt gaccgaggtg     1440

actcacgagt tttacgtcag aaagggtgga gctagaaaga ggcccgcccc caatgacgca     1500

gatataagtg agcccaagcg ggcctgtccg tcagttgcgc agccatcgac gtcagacgcg     1560

gaagctccgg tggactacgc ggacaggtac caaaacaaat gttctcgtca cgtgggtatg     1620

aatctgatgc tttttccctg ccggcaatgc gagagaatga atcagaatgt ggacatttgc     1680

ttcacgcacg gggtcatgga ctgtgccgag tgcttccccg tgtcagaatc tcaacccgtg     1740

tctgtcgtca gaaagcggac gtatcagaaa ctgtgtccga ttcatcacat catggggagg     1800

gcgcccgagg tggcctgctc ggcctgcgaa ctggccaatg tggacttgga tgactgtgac     1860

atggaacaat aa                                                         1872


<210> 5133
<211> 1611
<212> DNA
<213> Adeno-associated virus 4

<400> 5133
atgccggggt tctacgagat cgtgctgaag gtgcccagcg acctggacga gcacctgccc       60

ggcatttctg actcttttgt gagctgggtg gccgagaagg aatgggagct gccgccggat      120

tctgacatgg acttgaatct gattgagcag gcacccctga ccgtggccga aaagctgcaa      180

cgcgagttcc tggtcgagtg gcgccgcgtg agtaaggccc cggaggccct cttctttgtc      240

cagttcgaga agggggacag ctacttccac ctgcacatcc tggtggagac cgtgggcgtc      300

aaatccatgg tggtgggccg ctacgtgagc cagattaaag agaagctggt gacccgcatc      360

taccgcgggg tcgagccgca gcttccgaac tggttcgcgg tgaccaagac gcgtaatggc      420

gccggaggcg ggaacaaggt ggtggacgac tgctacatcc ccaactacct gctccccaag      480

acccagcccg agctccagtg ggcgtggact aacatggacc agtatataag cgcctgtttg      540

aatctcgcgg agcgtaaacg gctggtggcg cagcatctga cgcacgtgtc gcagacgcag      600

gagcagaaca aggaaaacca gaaccccaat tctgacgcgc cggtcatcag gtcaaaaacc      660

tccgccaggt acatggagct ggtcgggtgg ctggtggacc gcgggatcac gtcagaaaag      720

caatggatcc aggaggacca ggcgtcctac atctccttca acgccgcctc caactcgcgg      780

tcacaaatca aggccgcgct ggacaatgcc tccaaaatca tgagcctgac aaagacggct      840

ccggactacc tggtgggcca gaacccgccg gaggacattt ccagcaaccg catctaccga      900

atcctcgaga tgaacgggta cgatccgcag tacgcggcct ccgtcttcct gggctgggcg      960

caaaagaagt tcgggaagag gaacaccatc tggctctttg ggccggccac gacgggtaaa     1020

accaacatcg cggaagccat cgcccacgcc gtgcccttct acggctgcgt gaactggacc     1080

aatgagaact ttccgttcaa cgattgcgtc gacaagatgg tgatctggtg ggaggagggc     1140

aagatgacgg ccaaggtcgt agagagcgcc aaggccatcc tgggcggaag caaggtgcgc     1200

gtggaccaaa agtgcaagtc atcggcccag atcgacccaa ctcccgtgat cgtcacctcc     1260

aacaccaaca tgtgcgcggt catcgacgga aactcgacca ccttcgagca ccaacaacca     1320

ctccaggacc ggatgttcaa gttcgagctc accaagcgcc tggagcacga ctttggcaag     1380

gtcaccaagc aggaagtcaa agactttttc cggtgggcgt cagatcacgt gaccgaggtg     1440

actcacgagt tttacgtcag aaagggtgga gctagaaaga ggcccgcccc caatgacgca     1500

gatataagtg agcccaagcg ggcctgtccg tcagttgcgc agccatcgac gtcagacgcg     1560

gaagctccgg tggactacgc ggacagattg gctagaggac aacctctctg a              1611


<210> 5134
<211> 1872
<212> DNA
<213> Adeno-associated virus 4

<400> 5134
atgccggggt tctacgagat cgtgctgaag gtgcccagcg acctggacga gcacctgccc       60

ggcatttctg actcttttgt gagctgggtg gccgagaagg aatgggagct gccgccggat      120

tctgacatgg acttgaatct gattgagcag gcacccctga ccgtggccga aaagctgcaa      180

cgcgagttcc tggtcgagtg gcgccgcgtg agtaaggccc cggaggccct cttctttgtc      240

cagttcgaga agggggacag ctacttccac ctgcacatcc tggtggagac cgtgggcgtc      300

aaatccatgg tggtgggccg ctacgtgagc cagattaaag agaagctggt gacccgcatc      360

taccgcgggg tcgagccgca gcttccgaac tggttcgcgg tgaccaagac gcgtaatggc      420

gccggaggcg ggaacaaggt ggtggacgac tgctacatcc ccaactacct gctccccaag      480

acccagcccg agctccagtg ggcgtggact aacatggacc agtatataag cgcctgtttg      540

aatctcgcgg agcgtaaacg gctggtggcg cagcatctga cgcacgtgtc gcagacgcag      600

gagcagaaca aggaaaacca gaaccccaat tctgacgcgc cggtcatcag gtcaaaaacc      660

tccgccaggt acatggagct ggtcgggtgg ctggtggacc gcgggatcac gtcagaaaag      720

caatggatcc aggaggacca ggcgtcctac atctccttca acgccgcctc caactcgcgg      780

tcacaaatca aggccgcgct ggacaatgcc tccaaaatca tgagcctgac aaagacggct      840

ccggactacc tggtgggcca gaacccgccg gaggacattt ccagcaaccg catctaccga      900

atcctcgaga tgaacgggta cgatccgcag tacgcggcct ccgtcttcct gggctgggcg      960

caaaagaagt tcgggaagag gaacaccatc tggctctttg ggccggccac gacgggtaaa     1020

accaacatcg cggaagccat cgcccacgcc gtgcccttct acggctgcgt gaactggacc     1080

aatgagaact ttccgttcaa cgattgcgtc gacaagatgg tgatctggtg ggaggagggc     1140

aagatgacgg ccaaggtcgt agagagcgcc aaggccatcc tgggcggaag caaggtgcgc     1200

gtggaccaaa agtgcaagtc atcggcccag atcgacccaa ctcccgtgat cgtcacctcc     1260

aacaccaaca tgtgcgcggt catcgacgga aactcgacca ccttcgagca ccaacaacca     1320

ctccaggacc ggatgttcaa gttcgagctc accaagcgcc tggagcacga ctttggcaag     1380

gtcaccaagc aggaagtcaa agactttttc cggtgggcgt cagatcacgt gaccgaggtg     1440

actcacgagt tttacgtcag aaagggtgga gctagaaaga ggcccgcccc caatgacgca     1500

gatataagtg agcccaagcg ggcctgtccg tcagttgcgc agccatcgac gtcagacgcg     1560

gaagctccgg tggactacgc ggacaggtac caaaacaaat gttctcgtca cgtgggtatg     1620

aatctgatgc tttttccctg ccggcaatgc gagagaatga atcagaatgt ggacatttgc     1680

ttcacgcacg gggtcatgga ctgtgccgag tgcttccccg tgtcagaatc tcaacccgtg     1740

tctgtcgtca gaaagcggac gtatcagaaa ctgtgtccga ttcatcacat catggggagg     1800

gcgcccgagg tggcctgctc ggcctgcgaa ctggccaatg tggacttgga tgactgtgac     1860

atggaacaat aa                                                         1872


<210> 5135
<211> 1617
<212> DNA
<213> Adeno-associated virus 4


<220>
<221> modified_base
<222> (162)..(162)
<223> a, c, t or g

<400> 5135
atgcgtgcag cagctggcgg agctgcagtc gagggsggac aaggtgccga tggagtgggt       60

aatgcctcgg gtgattggca ttgcgattcc acctggtctg agggccacgt cacgaccacc      120

agcaccagaa cctgggtctt gcccacctac aacaaccacc tntacaagcg actcggagag      180

agcctgcagt ccaacaccta caacggattc tccaccccct ggggatactt tgacttcaac      240

cgcttccact gccacttctc accacgtgac tggcagcgac tcatcaacaa caactggggc      300

atgcgaccca aagccatgcg ggtcaaaatc ttcaacatcc aggtcaagga ggtcacgacg      360

tcgaacggcg agacaacggt ggctaataac cttaccagca cggttcagat ctttgcggac      420

tcgtcgtacg aactgccgta cgtgatggat gcgggtcaag agggcagcct gcctcctttt      480

cccaacgacg tctttatggt gccccagtac ggctactgtg gactggtgac cggcaacact      540

tcgcagcaac agactgacag aaatgccttc tactgcctgg agtactttcc ttcgcagatg      600

ctgcggactg gcaacaactt tgaaattacg tacagttttg agaaggtgcc tttccactcg      660

atgtacgcgc acagccagag cctggaccgg ctgatgaacc ctctcatcga ccagtacctg      720

tggggactgc aatcgaccac caccggaacc accctgaatg ccgggactgc caccaccaac      780

tttaccaagc tgcggcctac caacttttcc aactttaaaa agaactggct gcccgggcct      840

tcaatcaagc agcagggctt ctcaaagact gccaatcaaa actacaagat ccctgccacc      900

gggtcagaca gtctcatcaa atacgagacg cacagcactc tggacggaag atggagtgcc      960

ctgacccccg gacctccaat ggccacggct ggacctgcgg acagcaagtt cagcaacagc     1020

cagctcatct ttgcggggcc taaacagaac ggcaacacgg ccaccgtacc cgggactctg     1080

atcttcacct ctgaggagga gctggcagcc accaacgcca ccgatacgga catgtggggc     1140

aacctacctg gcggtgacca gagcaacagc aacctgccga ccgtggacag actgacagcc     1200

ttgggagccg tgcctggaat ggtctggcaa aacagagaca tttactacca gggtcccatt     1260

tgggccaaga ttcctcatac cgatggacac tttcacccct caccgctgat tggtgggttt     1320

gggctgaaac acccgcctcc tcaaattttt atcaagaaca ccccggtacc tgcgaatcct     1380

gcaacgacct tcagctctac tccggtaaac tccttcatta ctcagtacag cactggccag     1440

gtgtcggtgc agattgactg ggagatccag aaggagcggt ccaaacgctg gaaccccgag     1500

gtccagttta cctccaacta cggacagcaa aactctctgt tgtgggctcc cgatgcggct     1560

gggaaataca ctgagcctag ggctatcggt acccgctacc tcacccacca cctgtaa        1617


<210> 5136
<211> 939
<212> DNA
<213> Adeno-associated virus 4

<400> 5136
atggagctgg tcgggtggct ggtggaccgc gggatcacgt cagaaaagca atggatccag       60

gaggaccagg cgtcctacat ctccttcaac gccgcctcca actcgcggtc acaaatcaag      120

gccgcgctgg acaatgcctc caaaatcatg agcctgacaa agacggctcc ggactacctg      180

gtgggccaga acccgccgga ggacatttcc agcaaccgca tctaccgaat cctcgagatg      240

aacgggtacg atccgcagta cgcggcctcc gtcttcctgg gctgggcgca aaagaagttc      300

gggaagagga acaccatctg gctctttggg ccggccacga cgggtaaaac caacatcgcg      360

gaagccatcg cccacgccgt gcccttctac ggctgcgtga actggaccaa tgagaacttt      420

ccgttcaacg attgcgtcga caagatggtg atctggtggg aggagggcaa gatgacggcc      480

aaggtcgtag agagcgccaa ggccatcctg ggcggaagca aggtgcgcgt ggaccaaaag      540

tgcaagtcat cggcccagat cgacccaact cccgtgatcg tcacctccaa caccaacatg      600

tgcgcggtca tcgacggaaa ctcgaccacc ttcgagcacc aacaaccact ccaggaccgg      660

atgttcaagt tcgagctcac caagcgcctg gagcacgact ttggcaaggt caccaagcag      720

gaagtcaaag actttttccg gtgggcgtca gatcacgtga ccgaggtgac tcacgagttt      780

tacgtcagaa agggtggagc tagaaagagg cccgccccca atgacgcaga tataagtgag      840

cccaagcggg cctgtccgtc agttgcgcag ccatcgacgt cagacgcgga agctccggtg      900

gactacgcgg acagattggc tagaggacaa cctctctga                             939


<210> 5137
<211> 1197
<212> DNA
<213> Adeno-associated virus 4

<400> 5137
atggagctgg tcgggtggct ggtggaccgc gggatcacgt cagaaaagca atggatccag       60

gaggaccagg cgtcctacat ctccttcaac gccgcctcca actcgcggtc acaaatcaag      120

gccgcgctgg acaatgcctc caaaatcatg agcctgacaa agacggctcc ggactacctg      180

gtgggccaga acccgccgga ggacatttcc agcaaccgca tctaccgaat cctcgagatg      240

aacgggtacg atccgcagta cgcggcctcc gtcttcctgg gctgggcgca aaagaagttc      300

gggaagagga acaccatctg gctctttggg ccggccacga cgggtaaaac caacatcgcg      360

gaagccatcg cccacgccgt gcccttctac ggctgcgtga actggaccaa tgagaacttt      420

ccgttcaacg attgcgtcga caagatggtg atctggtggg aggagggcaa gatgacggcc      480

aaggtcgtag agagcgccaa ggccatcctg ggcggaagca aggtgcgcgt ggaccaaaag      540

tgcaagtcat cggcccagat cgacccaact cccgtgatcg tcacctccaa caccaacatg      600

tgcgcggtca tcgacggaaa ctcgaccacc ttcgagcacc aacaaccact ccaggaccgg      660

atgttcaagt tcgagctcac caagcgcctg gagcacgact ttggcaaggt caccaagcag      720

gaagtcaaag actttttccg gtgggcgtca gatcacgtga ccgaggtgac tcacgagttt      780

tacgtcagaa agggtggagc tagaaagagg cccgccccca atgacgcaga tataagtgag      840

cccaagcggg cctgtccgtc agttgcgcag ccatcgacgt cagacgcgga agctccggtg      900

gactacgcgg acaggtacca aaacaaatgt tctcgtcacg tgggtatgaa tctgatgctt      960

tttccctgcc ggcaatgcga gagaatgaat cagaatgtgg acatttgctt cacgcacggg     1020

gtcatggact gtgccgagtg cttccccgtg tcagaatctc aacccgtgtc tgtcgtcaga     1080

aagcggacgt atcagaaact gtgtccgatt catcacatca tggggagggc gcccgaggtg     1140

gcctgctcgg cctgcgaact ggccaatgtg gacttggatg actgtgacat ggaacaa        1197


<210> 5138
<211> 245
<212> DNA
<213> Adeno-associated virus 4

<400> 5138
ctccatcatc taggtttgcc cactgacgtc aatgtgacgt cctagggtta gggaggtccc       60

tgtattagca gtcacgtgag tgtcgtattt cgcggagcgt agcggagcgc ataccaagct      120

gccacgtcac agccacgtgg tccgtttgcg acagtttgcg acaccatgtg gtcaggaggg      180

tatataaccg cgagtgagcc agcgaggagc tccattttgc ccgcgaattt tgaacgagca      240

gcagc                                                                  245


<210> 5139
<211> 313
<212> PRT
<213> Adeno-associated virus 4


<220>
<221> MOD_RES
<222> (313)..(313)
<223> Any amino acid

<400> 5139
Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
1               5                   10                  15      


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
            20                  25                  30          


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
        35                  40                  45              


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Asn 
    50                  55                  60                  


Pro Pro Glu Asp Ile Ser Ser Asn Arg Ile Tyr Arg Ile Leu Glu Met 
65                  70                  75                  80  


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
                85                  90                  95      


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
            100                 105                 110         


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
        115                 120                 125             


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
    130                 135                 140                 


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
145                 150                 155                 160 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
                165                 170                 175     


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
            180                 185                 190         


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
        195                 200                 205             


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
    210                 215                 220                 


Glu Leu Thr Lys Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
225                 230                 235                 240 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
                245                 250                 255     


Thr His Glu Phe Tyr Val Arg Lys Gly Gly Ala Arg Lys Arg Pro Ala 
            260                 265                 270         


Pro Asn Asp Ala Asp Ile Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
        275                 280                 285             


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Pro Val Asp Tyr Ala Asp 
    290                 295                 300                 


Arg Leu Ala Arg Gly Gln Pro Leu Xaa 
305                 310             


<210> 5140
<211> 399
<212> PRT
<213> Adeno-associated virus 4

<400> 5140
Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
1               5                   10                  15      


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
            20                  25                  30          


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
        35                  40                  45              


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Asn 
    50                  55                  60                  


Pro Pro Glu Asp Ile Ser Ser Asn Arg Ile Tyr Arg Ile Leu Glu Met 
65                  70                  75                  80  


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
                85                  90                  95      


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
            100                 105                 110         


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
        115                 120                 125             


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
    130                 135                 140                 


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
145                 150                 155                 160 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
                165                 170                 175     


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
            180                 185                 190         


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
        195                 200                 205             


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
    210                 215                 220                 


Glu Leu Thr Lys Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
225                 230                 235                 240 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
                245                 250                 255     


Thr His Glu Phe Tyr Val Arg Lys Gly Gly Ala Arg Lys Arg Pro Ala 
            260                 265                 270         


Pro Asn Asp Ala Asp Ile Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
        275                 280                 285             


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Pro Val Asp Tyr Ala Asp 
    290                 295                 300                 


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
305                 310                 315                 320 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Val Asp Ile Cys 
                325                 330                 335     


Phe Thr His Gly Val Met Asp Cys Ala Glu Cys Phe Pro Val Ser Glu 
            340                 345                 350         


Ser Gln Pro Val Ser Val Val Arg Lys Arg Thr Tyr Gln Lys Leu Cys 
        355                 360                 365             


Pro Ile His His Ile Met Gly Arg Ala Pro Glu Val Ala Cys Ser Ala 
    370                 375                 380                 


Cys Glu Leu Ala Asn Val Asp Leu Asp Asp Cys Asp Met Glu Gln 
385                 390                 395                 


<210> 5141
<211> 623
<212> PRT
<213> Adeno-associated virus 4

<400> 5141
Met Pro Gly Phe Tyr Glu Ile Val Leu Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Ser Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Glu Phe Leu 
    50                  55                  60                  


Val Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Asp Ser Tyr Phe His Leu His Ile Leu Val Glu 
                85                  90                  95      


Thr Val Gly Val Lys Ser Met Val Val Gly Arg Tyr Val Ser Gln Ile 
            100                 105                 110         


Lys Glu Lys Leu Val Thr Arg Ile Tyr Arg Gly Val Glu Pro Gln Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Asp Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Asp Gln Tyr Ile 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Asn 
        275                 280                 285             


Pro Pro Glu Asp Ile Ser Ser Asn Arg Ile Tyr Arg Ile Leu Glu Met 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Lys Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
465                 470                 475                 480 


Thr His Glu Phe Tyr Val Arg Lys Gly Gly Ala Arg Lys Arg Pro Ala 
                485                 490                 495     


Pro Asn Asp Ala Asp Ile Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Pro Val Asp Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Val Asp Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Val Met Asp Cys Ala Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Arg Lys Arg Thr Tyr Gln Lys Leu Cys 
            580                 585                 590         


Pro Ile His His Ile Met Gly Arg Ala Pro Glu Val Ala Cys Ser Ala 
        595                 600                 605             


Cys Glu Leu Ala Asn Val Asp Leu Asp Asp Cys Asp Met Glu Gln 
    610                 615                 620             


<210> 5142
<211> 537
<212> PRT
<213> Adeno-associated virus 4


<220>
<221> MOD_RES
<222> (537)..(537)
<223> Any amino acid

<400> 5142
Met Pro Gly Phe Tyr Glu Ile Val Leu Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Ser Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Glu Phe Leu 
    50                  55                  60                  


Val Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Asp Ser Tyr Phe His Leu His Ile Leu Val Glu 
                85                  90                  95      


Thr Val Gly Val Lys Ser Met Val Val Gly Arg Tyr Val Ser Gln Ile 
            100                 105                 110         


Lys Glu Lys Leu Val Thr Arg Ile Tyr Arg Gly Val Glu Pro Gln Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Asp Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Asp Gln Tyr Ile 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Asn 
        275                 280                 285             


Pro Pro Glu Asp Ile Ser Ser Asn Arg Ile Tyr Arg Ile Leu Glu Met 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Lys Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
465                 470                 475                 480 


Thr His Glu Phe Tyr Val Arg Lys Gly Gly Ala Arg Lys Arg Pro Ala 
                485                 490                 495     


Pro Asn Asp Ala Asp Ile Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Pro Val Asp Tyr Ala Asp 
        515                 520                 525             


Arg Leu Ala Arg Gly Gln Pro Leu Xaa 
    530                 535         


<210> 5143
<211> 623
<212> PRT
<213> Adeno-associated virus 4

<400> 5143
Met Pro Gly Phe Tyr Glu Ile Val Leu Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Ser Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Glu Phe Leu 
    50                  55                  60                  


Val Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Asp Ser Tyr Phe His Leu His Ile Leu Val Glu 
                85                  90                  95      


Thr Val Gly Val Lys Ser Met Val Val Gly Arg Tyr Val Ser Gln Ile 
            100                 105                 110         


Lys Glu Lys Leu Val Thr Arg Ile Tyr Arg Gly Val Glu Pro Gln Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Asp Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Asp Gln Tyr Ile 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Asn 
        275                 280                 285             


Pro Pro Glu Asp Ile Ser Ser Asn Arg Ile Tyr Arg Ile Leu Glu Met 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Lys Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
465                 470                 475                 480 


Thr His Glu Phe Tyr Val Arg Lys Gly Gly Ala Arg Lys Arg Pro Ala 
                485                 490                 495     


Pro Asn Asp Ala Asp Ile Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Pro Val Asp Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Val Asp Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Val Met Asp Cys Ala Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Arg Lys Arg Thr Tyr Gln Lys Leu Cys 
            580                 585                 590         


Pro Ile His His Ile Met Gly Arg Ala Pro Glu Val Ala Cys Ser Ala 
        595                 600                 605             


Cys Glu Leu Ala Asn Val Asp Leu Asp Asp Cys Asp Met Glu Gln 
    610                 615                 620             


<210> 5144
<211> 544
<212> PRT
<213> Adeno-associated virus 4

<400> 5144
Met Ser Asp Asp Ser Glu Met Arg Ala Ala Ala Gly Gly Ala Ala Val 
1               5                   10                  15      


Glu Gly Gly Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp 
            20                  25                  30          


His Cys Asp Ser Thr Trp Ser Glu Gly His Val Thr Thr Thr Ser Thr 
        35                  40                  45              


Arg Thr Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Arg Leu 
    50                  55                  60                  


Gly Glu Ser Leu Gln Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp 
65                  70                  75                  80  


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
                85                  90                  95      


Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Met Arg Pro Lys Ala Met 
            100                 105                 110         


Arg Val Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn 
        115                 120                 125             


Gly Glu Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe 
    130                 135                 140                 


Ala Asp Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu 
145                 150                 155                 160 


Gly Ser Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr 
                165                 170                 175     


Gly Tyr Cys Gly Leu Val Thr Gly Asn Thr Ser Gln Gln Gln Thr Asp 
            180                 185                 190         


Arg Asn Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
        195                 200                 205             


Thr Gly Asn Asn Phe Glu Ile Thr Tyr Ser Phe Glu Lys Val Pro Phe 
    210                 215                 220                 


His Ser Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
225                 230                 235                 240 


Leu Ile Asp Gln Tyr Leu Trp Gly Leu Gln Ser Thr Thr Thr Gly Thr 
                245                 250                 255     


Thr Leu Asn Ala Gly Thr Ala Thr Thr Asn Phe Thr Lys Leu Arg Pro 
            260                 265                 270         


Thr Asn Phe Ser Asn Phe Lys Lys Asn Trp Leu Pro Gly Pro Ser Ile 
        275                 280                 285             


Lys Gln Gln Gly Phe Ser Lys Thr Ala Asn Gln Asn Tyr Lys Ile Pro 
    290                 295                 300                 


Ala Thr Gly Ser Asp Ser Leu Ile Lys Tyr Glu Thr His Ser Thr Leu 
305                 310                 315                 320 


Asp Gly Arg Trp Ser Ala Leu Thr Pro Gly Pro Pro Met Ala Thr Ala 
                325                 330                 335     


Gly Pro Ala Asp Ser Lys Phe Ser Asn Ser Gln Leu Ile Phe Ala Gly 
            340                 345                 350         


Pro Lys Gln Asn Gly Asn Thr Ala Thr Val Pro Gly Thr Leu Ile Phe 
        355                 360                 365             


Thr Ser Glu Glu Glu Leu Ala Ala Thr Asn Ala Thr Asp Thr Asp Met 
    370                 375                 380                 


Trp Gly Asn Leu Pro Gly Gly Asp Gln Ser Asn Ser Asn Leu Pro Thr 
385                 390                 395                 400 


Val Asp Arg Leu Thr Ala Leu Gly Ala Val Pro Gly Met Val Trp Gln 
                405                 410                 415     


Asn Arg Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
            420                 425                 430         


Thr Asp Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu 
        435                 440                 445             


Lys His Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala 
    450                 455                 460                 


Asn Pro Ala Thr Thr Phe Ser Ser Thr Pro Val Asn Ser Phe Ile Thr 
465                 470                 475                 480 


Gln Tyr Ser Thr Gly Gln Val Ser Val Gln Ile Asp Trp Glu Ile Gln 
                485                 490                 495     


Lys Glu Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn 
            500                 505                 510         


Tyr Gly Gln Gln Asn Ser Leu Leu Trp Ala Pro Asp Ala Ala Gly Lys 
        515                 520                 525             


Tyr Thr Glu Pro Arg Ala Ile Gly Thr Arg Tyr Leu Thr His His Leu 
    530                 535                 540                 


<210> 5145
<211> 734
<212> PRT
<213> Adeno-associated virus 4

<400> 5145
Met Thr Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu 
1               5                   10                  15      


Gly Val Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln 
65                  70                  75                  80  


Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Gln Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Gln Ala Gly Glu Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Leu Ile Glu Ser Pro Gln Gln Pro Asp Ser Ser Thr Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Lys Leu Val Phe Glu Asp Glu Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Thr Ser Gly Ala Met Ser 
            180                 185                 190         


Asp Asp Ser Glu Met Arg Ala Ala Ala Gly Gly Ala Ala Val Glu Gly 
        195                 200                 205             


Gly Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly His Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Arg Leu Gly Glu 
                245                 250                 255     


Ser Leu Gln Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Met Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Leu Val Thr Gly Asn Thr Ser Gln Gln Gln Thr Asp Arg Asn 
    370                 375                 380                 


Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly 
385                 390                 395                 400 


Asn Asn Phe Glu Ile Thr Tyr Ser Phe Glu Lys Val Pro Phe His Ser 
                405                 410                 415     


Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile 
            420                 425                 430         


Asp Gln Tyr Leu Trp Gly Leu Gln Ser Thr Thr Thr Gly Thr Thr Leu 
        435                 440                 445             


Asn Ala Gly Thr Ala Thr Thr Asn Phe Thr Lys Leu Arg Pro Thr Asn 
    450                 455                 460                 


Phe Ser Asn Phe Lys Lys Asn Trp Leu Pro Gly Pro Ser Ile Lys Gln 
465                 470                 475                 480 


Gln Gly Phe Ser Lys Thr Ala Asn Gln Asn Tyr Lys Ile Pro Ala Thr 
                485                 490                 495     


Gly Ser Asp Ser Leu Ile Lys Tyr Glu Thr His Ser Thr Leu Asp Gly 
            500                 505                 510         


Arg Trp Ser Ala Leu Thr Pro Gly Pro Pro Met Ala Thr Ala Gly Pro 
        515                 520                 525             


Ala Asp Ser Lys Phe Ser Asn Ser Gln Leu Ile Phe Ala Gly Pro Lys 
    530                 535                 540                 


Gln Asn Gly Asn Thr Ala Thr Val Pro Gly Thr Leu Ile Phe Thr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Ala Ala Thr Asn Ala Thr Asp Thr Asp Met Trp Gly 
                565                 570                 575     


Asn Leu Pro Gly Gly Asp Gln Ser Asn Ser Asn Leu Pro Thr Val Asp 
            580                 585                 590         


Arg Leu Thr Ala Leu Gly Ala Val Pro Gly Met Val Trp Gln Asn Arg 
        595                 600                 605             


Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Ala Thr Thr Phe Ser Ser Thr Pro Val Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Gln Ile Asp Trp Glu Ile Gln Lys Glu 
        675                 680                 685             


Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly 
    690                 695                 700                 


Gln Gln Asn Ser Leu Leu Trp Ala Pro Asp Ala Ala Gly Lys Tyr Thr 
705                 710                 715                 720 


Glu Pro Arg Ala Ile Gly Thr Arg Tyr Leu Thr His His Leu 
                725                 730                 


<210> 5146
<211> 598
<212> PRT
<213> Adeno-associated virus 4

<400> 5146
Thr Ala Pro Gly Lys Lys Arg Pro Leu Ile Glu Ser Pro Gln Gln Pro 
1               5                   10                  15      


Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Lys Gln Pro Ala Lys Lys 
            20                  25                  30          


Lys Leu Val Phe Glu Asp Glu Thr Gly Ala Gly Asp Gly Pro Pro Glu 
        35                  40                  45              


Gly Ser Thr Ser Gly Ala Met Ser Asp Asp Ser Glu Met Arg Ala Ala 
    50                  55                  60                  


Ala Gly Gly Ala Ala Val Glu Gly Gly Gln Gly Ala Asp Gly Val Gly 
65                  70                  75                  80  


Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp Ser Glu Gly His 
                85                  90                  95      


Val Thr Thr Thr Ser Thr Arg Thr Trp Val Leu Pro Thr Tyr Asn Asn 
            100                 105                 110         


His Leu Tyr Lys Arg Leu Gly Glu Ser Leu Gln Ser Asn Thr Tyr Asn 
        115                 120                 125             


Gly Phe Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys 
    130                 135                 140                 


His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly 
145                 150                 155                 160 


Met Arg Pro Lys Ala Met Arg Val Lys Ile Phe Asn Ile Gln Val Lys 
                165                 170                 175     


Glu Val Thr Thr Ser Asn Gly Glu Thr Thr Val Ala Asn Asn Leu Thr 
            180                 185                 190         


Ser Thr Val Gln Ile Phe Ala Asp Ser Ser Tyr Glu Leu Pro Tyr Val 
        195                 200                 205             


Met Asp Ala Gly Gln Glu Gly Ser Leu Pro Pro Phe Pro Asn Asp Val 
    210                 215                 220                 


Phe Met Val Pro Gln Tyr Gly Tyr Cys Gly Leu Val Thr Gly Asn Thr 
225                 230                 235                 240 


Ser Gln Gln Gln Thr Asp Arg Asn Ala Phe Tyr Cys Leu Glu Tyr Phe 
                245                 250                 255     


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Ile Thr Tyr Ser 
            260                 265                 270         


Phe Glu Lys Val Pro Phe His Ser Met Tyr Ala His Ser Gln Ser Leu 
        275                 280                 285             


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Trp Gly Leu Gln 
    290                 295                 300                 


Ser Thr Thr Thr Gly Thr Thr Leu Asn Ala Gly Thr Ala Thr Thr Asn 
305                 310                 315                 320 


Phe Thr Lys Leu Arg Pro Thr Asn Phe Ser Asn Phe Lys Lys Asn Trp 
                325                 330                 335     


Leu Pro Gly Pro Ser Ile Lys Gln Gln Gly Phe Ser Lys Thr Ala Asn 
            340                 345                 350         


Gln Asn Tyr Lys Ile Pro Ala Thr Gly Ser Asp Ser Leu Ile Lys Tyr 
        355                 360                 365             


Glu Thr His Ser Thr Leu Asp Gly Arg Trp Ser Ala Leu Thr Pro Gly 
    370                 375                 380                 


Pro Pro Met Ala Thr Ala Gly Pro Ala Asp Ser Lys Phe Ser Asn Ser 
385                 390                 395                 400 


Gln Leu Ile Phe Ala Gly Pro Lys Gln Asn Gly Asn Thr Ala Thr Val 
                405                 410                 415     


Pro Gly Thr Leu Ile Phe Thr Ser Glu Glu Glu Leu Ala Ala Thr Asn 
            420                 425                 430         


Ala Thr Asp Thr Asp Met Trp Gly Asn Leu Pro Gly Gly Asp Gln Ser 
        435                 440                 445             


Asn Ser Asn Leu Pro Thr Val Asp Arg Leu Thr Ala Leu Gly Ala Val 
    450                 455                 460                 


Pro Gly Met Val Trp Gln Asn Arg Asp Ile Tyr Tyr Gln Gly Pro Ile 
465                 470                 475                 480 


Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu 
                485                 490                 495     


Ile Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Phe Ile Lys 
            500                 505                 510         


Asn Thr Pro Val Pro Ala Asn Pro Ala Thr Thr Phe Ser Ser Thr Pro 
        515                 520                 525             


Val Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Gln 
    530                 535                 540                 


Ile Asp Trp Glu Ile Gln Lys Glu Arg Ser Lys Arg Trp Asn Pro Glu 
545                 550                 555                 560 


Val Gln Phe Thr Ser Asn Tyr Gly Gln Gln Asn Ser Leu Leu Trp Ala 
                565                 570                 575     


Pro Asp Ala Ala Gly Lys Tyr Thr Glu Pro Arg Ala Ile Gly Thr Arg 
            580                 585                 590         


Tyr Leu Thr His His Leu 
        595             


<210> 5147
<211> 129
<212> DNA
<213> Adeno-associated virus 4

<400> 5147
ttggccactc cctctatgcg cgctcgctca ctcactcggc cctgcggcca gaggccggca       60

gtctggagac ctttggtgtc cagggcaggg ccgagtgagt gagcgagcgc gcatagaggg      120

agtggccaa                                                              129


<210> 5148
<211> 125
<212> DNA
<213> Adeno-associated virus 4

<400> 5148
ttggccactc cctctatgcg cgctcgctca ctcactcggc cctggagacc aaaggtctcc       60

agactgccgg cctctggccg gcagggccga gtgagtgagc gagcgcgcat agagggagtg      120

gccaa                                                                  125


<210> 5149
<211> 4768
<212> DNA
<213> Adeno-associated virus 4


<220>
<221> modified_base
<222> (3009)..(3009)
<223> a, c, t or g

<400> 5149
ttggccactc cctctatgcg cgctcgctca ctcactcggc cctggagacc aaaggtctcc       60

agactgccgg cctctggccg gcagggccga gtgagtgagc gagcgcgcat agagggagtg      120

gccaactcca tcatctaggt ttgcccactg acgtcaatgt gacgtcctag ggttagggag      180

gtccctgtat tagcagtcac gtgagtgtcg tatttcgcgg agcgtagcgg agcgcatacc      240

aagctgccac gtcacagcca cgtggtccgt ttgcgacagt ttgcgacacc atgtggtcag      300

gagggtatat aaccgcgagt gagccagcga ggagctccat tttgcccgcg aattttgaac      360

gagcagcagc catgccgggg ttctacgaga tcgtgctgaa ggtgcccagc gacctggacg      420

agcacctgcc cggcatttct gactcttttg tgagctgggt ggccgagaag gaatgggagc      480

tgccgccgga ttctgacatg gacttgaatc tgattgagca ggcacccctg accgtggccg      540

aaaagctgca acgcgagttc ctggtcgagt ggcgccgcgt gagtaaggcc ccggaggccc      600

tcttctttgt ccagttcgag aagggggaca gctacttcca cctgcacatc ctggtggaga      660

ccgtgggcgt caaatccatg gtggtgggcc gctacgtgag ccagattaaa gagaagctgg      720

tgacccgcat ctaccgcggg gtcgagccgc agcttccgaa ctggttcgcg gtgaccaaga      780

cgcgtaatgg cgccggaggc gggaacaagg tggtggacga ctgctacatc cccaactacc      840

tgctccccaa gacccagccc gagctccagt gggcgtggac taacatggac cagtatataa      900

gcgcctgttt gaatctcgcg gagcgtaaac ggctggtggc gcagcatctg acgcacgtgt      960

cgcagacgca ggagcagaac aaggaaaacc agaaccccaa ttctgacgcg ccggtcatca     1020

ggtcaaaaac ctccgccagg tacatggagc tggtcgggtg gctggtggac cgcgggatca     1080

cgtcagaaaa gcaatggatc caggaggacc aggcgtccta catctccttc aacgccgcct     1140

ccaactcgcg gtcacaaatc aaggccgcgc tggacaatgc ctccaaaatc atgagcctga     1200

caaagacggc tccggactac ctggtgggcc agaacccgcc ggaggacatt tccagcaacc     1260

gcatctaccg aatcctcgag atgaacgggt acgatccgca gtacgcggcc tccgtcttcc     1320

tgggctgggc gcaaaagaag ttcgggaaga ggaacaccat ctggctcttt gggccggcca     1380

cgacgggtaa aaccaacatc gcggaagcca tcgcccacgc cgtgcccttc tacggctgcg     1440

tgaactggac caatgagaac tttccgttca acgattgcgt cgacaagatg gtgatctggt     1500

gggaggaggg caagatgacg gccaaggtcg tagagagcgc caaggccatc ctgggcggaa     1560

gcaaggtgcg cgtggaccaa aagtgcaagt catcggccca gatcgaccca actcccgtga     1620

tcgtcacctc caacaccaac atgtgcgcgg tcatcgacgg aaactcgacc accttcgagc     1680

accaacaacc actccaggac cggatgttca agttcgagct caccaagcgc ctggagcacg     1740

actttggcaa ggtcaccaag caggaagtca aagacttttt ccggtgggcg tcagatcacg     1800

tgaccgaggt gactcacgag ttttacgtca gaaagggtgg agctagaaag aggcccgccc     1860

ccaatgacgc agatataagt gagcccaagc gggcctgtcc gtcagttgcg cagccatcga     1920

cgtcagacgc ggaagctccg gtggactacg cggacaggta ccaaaacaaa tgttctcgtc     1980

acgtgggtat gaatctgatg ctttttccct gccggcaatg cgagagaatg aatcagaatg     2040

tggacatttg cttcacgcac ggggtcatgg actgtgccga gtgcttcccc gtgtcagaat     2100

ctcaacccgt gtctgtcgtc agaaagcgga cgtatcagaa actgtgtccg attcatcaca     2160

tcatggggag ggcgcccgag gtggcctgct cggcctgcga actggccaat gtggacttgg     2220

atgactgtga catggaacaa taaatgactc aaaccagata tgactgacgg ttaccttcca     2280

gattggctag aggacaacct ctctgaaggc gttcgagagt ggtgggcgct gcaacctgga     2340

gcccctaaac ccaaggcaaa tcaacaacat caggacaacg ctcggggtct tgtgcttccg     2400

ggttacaaat acctcggacc cggcaacgga ctcgacaagg gggaacccgt caacgcagcg     2460

gacgcggcag ccctcgagca cgacaaggcc tacgaccagc agctcaaggc cggtgacaac     2520

ccctacctca agtacaacca cgccgacgcg gagttccagc agcggcttca gggcgacaca     2580

ccgtttgggg gcaacctcgg cagagcagtc ttccaggcca aaaagagggt tcttgaacct     2640

cttggtctgg ttgagcaagc gggtgagacg gctcctggaa agaagagacc gttgattgaa     2700

tccccccagc agcccgactc ctccacgggt atcggcaaaa aaggcaagca gccggctaaa     2760

aagaagctcg ttttcgaaga cgaaactgga gcaggcgacg gaccccctga gggatcaact     2820

tccggagcca tgtctgatga cagtgagatg cgtgcagcag ctggcggagc tgcagtcgag     2880

ggsggacaag gtgccgatgg agtgggtaat gcctcgggtg attggcattg cgattccacc     2940

tggtctgagg gccacgtcac gaccaccagc accagaacct gggtcttgcc cacctacaac     3000

aaccacctnt acaagcgact cggagagagc ctgcagtcca acacctacaa cggattctcc     3060

accccctggg gatactttga cttcaaccgc ttccactgcc acttctcacc acgtgactgg     3120

cagcgactca tcaacaacaa ctggggcatg cgacccaaag ccatgcgggt caaaatcttc     3180

aacatccagg tcaaggaggt cacgacgtcg aacggcgaga caacggtggc taataacctt     3240

accagcacgg ttcagatctt tgcggactcg tcgtacgaac tgccgtacgt gatggatgcg     3300

ggtcaagagg gcagcctgcc tccttttccc aacgacgtct ttatggtgcc ccagtacggc     3360

tactgtggac tggtgaccgg caacacttcg cagcaacaga ctgacagaaa tgccttctac     3420

tgcctggagt actttccttc gcagatgctg cggactggca acaactttga aattacgtac     3480

agttttgaga aggtgccttt ccactcgatg tacgcgcaca gccagagcct ggaccggctg     3540

atgaaccctc tcatcgacca gtacctgtgg ggactgcaat cgaccaccac cggaaccacc     3600

ctgaatgccg ggactgccac caccaacttt accaagctgc ggcctaccaa cttttccaac     3660

tttaaaaaga actggctgcc cgggccttca atcaagcagc agggcttctc aaagactgcc     3720

aatcaaaact acaagatccc tgccaccggg tcagacagtc tcatcaaata cgagacgcac     3780

agcactctgg acggaagatg gagtgccctg acccccggac ctccaatggc cacggctgga     3840

cctgcggaca gcaagttcag caacagccag ctcatctttg cggggcctaa acagaacggc     3900

aacacggcca ccgtacccgg gactctgatc ttcacctctg aggaggagct ggcagccacc     3960

aacgccaccg atacggacat gtggggcaac ctacctggcg gtgaccagag caacagcaac     4020

ctgccgaccg tggacagact gacagccttg ggagccgtgc ctggaatggt ctggcaaaac     4080

agagacattt actaccaggg tcccatttgg gccaagattc ctcataccga tggacacttt     4140

cacccctcac cgctgattgg tgggtttggg ctgaaacacc cgcctcctca aatttttatc     4200

aagaacaccc cggtacctgc gaatcctgca acgaccttca gctctactcc ggtaaactcc     4260

ttcattactc agtacagcac tggccaggtg tcggtgcaga ttgactggga gatccagaag     4320

gagcggtcca aacgctggaa ccccgaggtc cagtttacct ccaactacgg acagcaaaac     4380

tctctgttgt gggctcccga tgcggctggg aaatacactg agcctagggc tatcggtacc     4440

cgctacctca cccaccacct gtaataacct gttaatcaat aaaccggttt attcgtttca     4500

gttgaacttt ggtctccgtg tccttcttat cttatctcgt ttccatggct actgcgtaca     4560

taagcagcgg cctgcggcgc ttgcgcttcg cggtttacaa ctgccggtta atcagtaact     4620

tctggcaaac catgatgatg gagttggcca ctccctctat gcgcgctcgc tcactcactc     4680

ggccctggag accaaaggtc tccagactgc cggcctctgg ccggcagggc cgagtgagtg     4740

agcgagcgcg catagaggga gtggccaa                                        4768


<210> 5150
<211> 725
<212> PRT
<213> Adeno-associated virus 5

<400> 5150
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg 
    130                 135                 140                 


Ile Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp 
145                 150                 155                 160 


Ser Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser 
                165                 170                 175     


Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp 
            180                 185                 190         


Thr Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly 
        195                 200                 205             


Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr 
    210                 215                 220                 


Trp Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu 
225                 230                 235                 240 


Pro Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val 
                245                 250                 255     


Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
            260                 265                 270         


Tyr Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp 
        275                 280                 285             


Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg 
    290                 295                 300                 


Val Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser 
305                 310                 315                 320 


Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr 
                325                 330                 335     


Asp Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly 
            340                 345                 350         


Cys Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly 
        355                 360                 365             


Tyr Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser 
    370                 375                 380                 


Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly 
385                 390                 395                 400 


Asn Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser 
                405                 410                 415     


Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val 
            420                 425                 430         


Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val 
        435                 440                 445             


Gln Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn 
    450                 455                 460                 


Trp Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser 
465                 470                 475                 480 


Gly Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met 
                485                 490                 495     


Glu Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met 
            500                 505                 510         


Thr Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met 
        515                 520                 525             


Ile Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu 
    530                 535                 540                 


Glu Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn 
545                 550                 555                 560 


Arg Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser 
                565                 570                 575     


Ser Thr Thr Ala Pro Thr Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val 
            580                 585                 590         


Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        595                 600                 605             


Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala 
    610                 615                 620                 


Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys 
625                 630                 635                 640 


Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val 
                645                 650                 655     


Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met 
            660                 665                 670         


Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile 
        675                 680                 685             


Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro 
    690                 695                 700                 


Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr 
705                 710                 715                 720 


Leu Thr Arg Pro Leu 
                725 


<210> 5151
<211> 724
<212> PRT
<213> Adeno-associated virus 5

<400> 5151
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


Thr Arg Pro Leu 
                


<210> 5152
<211> 2175
<212> DNA
<213> Adeno-associated virus 5

<400> 5152
atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag       60

tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa      120

gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga      180

ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag      240

cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag      300

gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc      360

aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc      420

ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc      480

aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc      540

ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca      600

ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc      660

gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc      720

agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc      780

aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc      840

cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg      900

tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc      960

accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag     1020

ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc     1080

tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc     1140

gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac     1200

aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt     1260

cagaacctgt tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc     1320

acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc     1380

tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg     1440

gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg     1500

agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc     1560

tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc     1620

acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc     1680

gtggcgtaca acgtcggcgg gcagatggcc accaacaacc agagctccac cactgccccc     1740

gcgaccggca cgtacaacct ccaggaaatc gtgcccggca gcgtgtggat ggagagggac     1800

gtgtacctcc aaggacccat ctgggccaag atcccagaga cgggggcgca ctttcacccc     1860

tctccggcca tgggcggatt cggactcaaa cacccaccgc ccatgatgct catcaagaac     1920

acgcctgtgc ccggaaatat caccagcttc tcggacgtgc ccgtcagcag cttcatcacc     1980

cagtacagca ccgggcaggt caccgtggag atggagtggg agctcaagaa ggaaaactcc     2040

aagaggtgga acccagagat ccagtacaca aacaactaca acgaccccca gtttgtggac     2100

tttgccccgg acagcaccgg ggaatacaga accaccagac ctatcggaac ccgatacctt     2160

acccgacccc tttaa                                                      2175


<210> 5153
<211> 2208
<212> DNA
<213> Adeno-associated virus 6

<400> 5153
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt accttcagct acaccttcga ggacgtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt accggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctg                  2208


<210> 5154
<211> 736
<212> PRT
<213> Adeno-associated virus 6

<400> 5154
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5155
<211> 623
<212> PRT
<213> Adeno-associated virus 6

<400> 5155
Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Val Gln Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Leu His Ile Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Asp Lys Leu Val Gln Thr Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Glu Tyr Ile 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala His Asp 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Leu Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ala Leu Thr Lys Ser Ala Pro Asp Tyr Leu Val Gly Pro Ala 
        275                 280                 285             


Pro Pro Ala Asp Ile Lys Thr Asn Arg Ile Tyr Arg Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Ala Tyr Ala Gly Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Arg Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Glu Phe Phe Arg Trp Ala Gln Asp His Val Thr Glu Val 
465                 470                 475                 480 


Ala His Glu Phe Tyr Val Arg Lys Gly Gly Ala Asn Lys Arg Pro Ala 
                485                 490                 495     


Pro Asp Asp Ala Asp Lys Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
            500                 505                 510         


Ala Asp Pro Ser Thr Ser Asp Ala Glu Gly Ala Pro Val Asp Phe Ala 
        515                 520                 525             


Asp Arg Tyr Gln Asn Lys Cys Ser Arg His Ala Gly Met Leu Gln Met 
    530                 535                 540                 


Leu Phe Pro Cys Lys Thr Cys Glu Arg Met Asn Gln Asn Phe Asn Ile 
545                 550                 555                 560 


Cys Phe Thr His Gly Thr Arg Asp Cys Ser Glu Cys Phe Pro Gly Val 
                565                 570                 575     


Ser Glu Ser Gln Pro Val Val Arg Lys Arg Thr Tyr Arg Lys Leu Cys 
            580                 585                 590         


Ala Ile His His Leu Leu Gly Arg Ala Pro Glu Ile Ala Cys Ser Ala 
        595                 600                 605             


Cys Asp Leu Val Asn Val Asp Leu Asp Asp Cys Val Ser Glu Gln 
    610                 615                 620             


<210> 5156
<211> 4683
<212> DNA
<213> Adeno-associated virus 6

<400> 5156
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgtatt agaggtcacg tgagtgtttt gcgacatttt gcgacaccat      240

gtggtcacgc tgggtattta agcccgagtg agcacgcagg gtctccattt tgaagcggga      300

ggtttgaacg cgcagcgcca tgccggggtt ttacgagatt gtgattaagg tccccagcga      360

ccttgacgag catctgcccg gcatttctga cagctttgtg aactgggtgg ccgagaagga      420

atgggagttg ccgccagatt ctgacatgga tctgaatctg attgagcagg cacccctgac      480

cgtggccgag aagctgcagc gcgacttcct ggtccagtgg cgccgcgtga gtaaggcccc      540

ggaggccctc ttctttgttc agttcgagaa gggcgagtcc tacttccacc tccatattct      600

ggtggagacc acgggggtca aatccatggt gctgggccgc ttcctgagtc agattaggga      660

caagctggtg cagaccatct accgcgggat cgagccgacc ctgcccaact ggttcgcggt      720

gaccaagacg cgtaatggcg ccggaggggg gaacaaggtg gtggacgagt gctacatccc      780

caactacctc ctgcccaaga ctcagcccga gctgcagtgg gcgtggacta acatggagga      840

gtatataagc gcgtgtttaa acctggccga gcgcaaacgg ctcgtggcgc acgacctgac      900

ccacgtcagc cagacccagg agcagaacaa ggagaatctg aaccccaatt ctgacgcgcc      960

tgtcatccgg tcaaaaacct ccgcacgcta catggagctg gtcgggtggc tggtggaccg     1020

gggcatcacc tccgagaagc agtggatcca ggaggaccag gcctcgtaca tctccttcaa     1080

cgccgcctcc aactcgcggt cccagatcaa ggccgctctg gacaatgccg gcaagatcat     1140

ggcgctgacc aaatccgcgc ccgactacct ggtaggcccc gctccgcccg ccgacattaa     1200

aaccaaccgc atttaccgca tcctggagct gaacggctac gaccctgcct acgccggctc     1260

cgtctttctc ggctgggccc agaaaaggtt cggaaaacgc aacaccatct ggctgtttgg     1320

gccggccacc acgggcaaga ccaacatcgc ggaagccatc gcccacgccg tgcccttcta     1380

cggctgcgtc aactggacca atgagaactt tcccttcaac gattgcgtcg acaagatggt     1440

gatctggtgg gaggagggca agatgacggc caaggtcgtg gagtccgcca aggccattct     1500

cggcggcagc aaggtgcgcg tggaccaaaa gtgcaagtcg tccgcccaga tcgatcccac     1560

ccccgtgatc gtcacctcca acaccaacat gtgcgccgtg attgacggga acagcaccac     1620

cttcgagcac cagcagccgt tgcaggaccg gatgttcaaa tttgaactca cccgccgtct     1680

ggagcatgac tttggcaagg tgacaaagca ggaagtcaaa gagttcttcc gctgggcgca     1740

ggatcacgtg accgaggtgg cgcatgagtt ctacgtcaga aagggtggag ccaacaagag     1800

acccgccccc gatgacgcgg ataaaagcga gcccaagcgg gcctgcccct cagtcgcgga     1860

tccatcgacg tcagacgcgg aaggagctcc ggtggacttt gccgacaggt accaaaacaa     1920

atgttctcgt cacgcgggca tgcttcagat gctgtttccc tgcaaaacat gcgagagaat     1980

gaatcagaat ttcaacattt gcttcacgca cgggaccaga gactgttcag aatgtttccc     2040

cggcgtgtca gaatctcaac cggtcgtcag aaagaggacg tatcggaaac tctgtgccat     2100

tcatcatctg ctggggcggg ctcccgagat tgcttgctcg gcctgcgatc tggtcaacgt     2160

ggatctggat gactgtgttt ctgagcaata aatgacttaa accaggtatg gctgccgatg     2220

gttatcttcc agattggctc gaggacaacc tctctgaggg cattcgcgag tggtgggact     2280

tgaaacctgg agccccgaaa cccaaagcca accagcaaaa gcaggacgac ggccggggtc     2340

tggtgcttcc tggctacaag tacctcggac ccttcaacgg actcgacaag ggggagcccg     2400

tcaacgcggc ggatgcagcg gccctcgagc acgacaaggc ctacgaccag cagctcaaag     2460

cgggtgacaa tccgtacctg cggtataacc acgccgacgc cgagtttcag gagcgtctgc     2520

aagaagatac gtcttttggg ggcaacctcg ggcgagcagt cttccaggcc aagaagaggg     2580

ttctcgaacc ttttggtctg gttgaggaag gtgctaagac ggctcctgga aagaaacgtc     2640

cggtagagca gtcgccacaa gagccagact cctcctcggg cattggcaag acaggccagc     2700

agcccgctaa aaagagactc aattttggtc agactggcga ctcagagtca gtccccgacc     2760

cacaacctct cggagaacct ccagcaaccc ccgctgctgt gggacctact acaatggctt     2820

caggcggtgg cgcaccaatg gcagacaata acgaaggcgc cgacggagtg ggtaatgcct     2880

caggaaattg gcattgcgat tccacatggc tgggcgacag agtcatcacc accagcaccc     2940

gaacatgggc cttgcccacc tataacaacc acctctacaa gcaaatctcc agtgcttcaa     3000

cgggggccag caacgacaac cactacttcg gctacagcac cccctggggg tattttgatt     3060

tcaacagatt ccactgccat ttctcaccac gtgactggca gcgactcatc aacaacaatt     3120

ggggattccg gcccaagaga ctcaacttca agctcttcaa catccaagtc aaggaggtca     3180

cgacgaatga tggcgtcacg accatcgcta ataaccttac cagcacggtt caagtcttct     3240

cggactcgga gtaccagttg ccgtacgtcc tcggctctgc gcaccagggc tgcctccctc     3300

cgttcccggc ggacgtgttc atgattccgc agtacggcta cctaacgctc aacaatggca     3360

gccaggcagt gggacggtca tccttttact gcctggaata tttcccatcg cagatgctga     3420

gaacgggcaa taactttacc ttcagctaca ccttcgagga cgtgcctttc cacagcagct     3480

acgcgcacag ccagagcctg gaccggctga tgaatcctct catcgaccag tacctgtatt     3540

acctgaacag aactcagaat cagtccggaa gtgcccaaaa caaggacttg ctgtttagcc     3600

gggggtctcc agctggcatg tctgttcagc ccaaaaactg gctacctgga ccctgttacc     3660

ggcagcagcg cgtttctaaa acaaaaacag acaacaacaa cagcaacttt acctggactg     3720

gtgcttcaaa atataacctt aatgggcgtg aatctataat caaccctggc actgctatgg     3780

cctcacacaa agacgacaaa gacaagttct ttcccatgag cggtgtcatg atttttggaa     3840

aggagagcgc cggagcttca aacactgcat tggacaatgt catgatcaca gacgaagagg     3900

aaatcaaagc cactaacccc gtggccaccg aaagatttgg gactgtggca gtcaatctcc     3960

agagcagcag cacagaccct gcgaccggag atgtgcatgt tatgggagcc ttacctggaa     4020

tggtgtggca agacagagac gtatacctgc agggtcctat ttgggccaaa attcctcaca     4080

cggatggaca ctttcacccg tctcctctca tgggcggctt tggacttaag cacccgcctc     4140

ctcagatcct catcaaaaac acgcctgttc ctgcgaatcc tccggcagag ttttcggcta     4200

caaagtttgc ttcattcatc acccagtatt ccacaggaca agtgagcgtg gagattgaat     4260

gggagctgca gaaagaaaac agcaaacgct ggaatcccga agtgcagtat acatctaact     4320

atgcaaaatc tgccaacgtt gatttcactg tggacaacaa tggactttat actgagcctc     4380

gccccattgg cacccgttac ctcacccgtc ccctgtaatt gtgtgttaat caataaaccg     4440

gttaattcgt gtcagttgaa ctttggtctc atgtcgttat tatcttatct ggtcaccata     4500

gcaaccggtt acacattaac tgcttagttg cgcttcgcga atacccctag tgatggagtt     4560

gcccactccc tctatgcgcg ctcgctcgct cggtggggcc ggcagagcag agctctgccg     4620

tctgcggacc tttggtccgc aggccccacc gagcgagcga gcgcgcatag agggagtggg     4680

caa                                                                   4683


<210> 5157
<211> 2211
<212> DNA
<213> Adeno-associated virus 6

<400> 5157
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt accttcagct acaccttcga ggacgtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt accggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5158
<211> 2214
<212> DNA
<213> Adeno-associated virus 7

<400> 5158
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

aacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtcattt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

gcaaagaaga gaccggtaga gccgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctctcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacag tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

attaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccagtg aaactgcagg tagtaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagaagctgc ggttcaagct cttcaacatc      960

caggtcaagg aggtcacgac gaatgacggc gttacgacca tcgctaataa ccttaccagc     1020

acgattcagg tattctcgga ctcggaatac cagctgccgt acgtcctcgg ctctgcgcac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttcctcagta cggctacctg     1140

actctcaaca atggcagtca gtctgtggga cgttcctcct tctactgcct ggagtacttc     1200

ccctctcaga tgctgagaac gggcaacaac tttgagttca gctacagctt cgaggacgtg     1260

cctttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcccctcatc     1320

gaccagtact tgtactacct ggccagaaca cagagtaacc caggaggcac agctggcaat     1380

cgggaactgc agttttacca gggcgggcct tcaactatgg ccgaacaagc caagaattgg     1440

ttacctggac cttgcttccg gcaacaaaga gtctccaaaa cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggcagaaa ctcgttggtt     1560

aatcccggcg tcgccatggc aactcacaag gacgacgagg accgcttttt cccatccagc     1620

ggagtcctga tttttggaaa aactggagca actaacaaaa ctacattgga aaatgtgtta     1680

atgacaaatg aagaagaaat tcgtcctact aatcctgtag ccacggaaga atacgggata     1740

gtcagcagca acttacaagc ggctaatact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggcatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga tggcaacttt cacccgtctc ctttgatggg cggctttgga     1920

cttaaacatc cgcctcctca gatcctgatc aagaacactc ccgttcccgc taatcctccg     1980

gaggtgttta ctcctgccaa gtttgcttcg ttcatcacac agtacagcac cggacaagtc     2040

agcgtggaaa tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatt     2100

cagtacacct ccaactttga aaagcagact ggtgtggact ttgccgttga cagccagggt     2160

gtttactctg agcctcgccc tattggcact cgttacctca cccgtaatct gtaa           2214


<210> 5159
<211> 738
<212> PRT
<213> Adeno-associated virus 7

<400> 5159
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5160
<211> 737
<212> PRT
<213> Adeno-associated virus 7

<400> 5160
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Ala Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Val Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Glu Thr Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Pro Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Glu Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5161
<211> 623
<212> PRT
<213> Adeno-associated virus 7

<400> 5161
Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Val Gln Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Leu His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Val Gln Thr Ile Tyr Arg Gly Val Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Glu Tyr Ile 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Leu Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ala Leu Thr Lys Ser Ala Pro Asp Tyr Leu Val Gly Pro Ser 
        275                 280                 285             


Leu Pro Ala Asp Ile Lys Thr Asn Arg Ile Tyr Arg Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Ala Tyr Ala Gly Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Glu Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
465                 470                 475                 480 


Ala His Glu Phe Tyr Val Arg Lys Gly Gly Ala Ser Lys Arg Pro Ala 
                485                 490                 495     


Pro Asp Asp Ala Asp Ile Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
            500                 505                 510         


Ala Asp Pro Ser Thr Ser Asp Ala Glu Gly Ala Pro Val Asp Phe Ala 
        515                 520                 525             


Asp Arg Tyr Gln Asn Lys Cys Ser Arg His Ala Gly Met Ile Gln Met 
    530                 535                 540                 


Leu Phe Pro Cys Lys Thr Cys Glu Arg Met Asn Gln Asn Phe Asn Ile 
545                 550                 555                 560 


Cys Phe Thr His Gly Val Arg Asp Cys Leu Glu Cys Phe Pro Gly Val 
                565                 570                 575     


Ser Glu Ser Gln Pro Val Val Arg Lys Lys Thr Tyr Arg Lys Leu Cys 
            580                 585                 590         


Ala Ile His His Leu Leu Gly Arg Ala Pro Glu Ile Ala Cys Ser Ala 
        595                 600                 605             


Cys Asp Leu Val Asn Val Asp Leu Asp Asp Cys Val Ser Glu Gln 
    610                 615                 620             


<210> 5162
<211> 4721
<212> DNA
<213> Adeno-associated virus 7

<400> 5162
ttggccactc cctctatgcg cgctcgctcg ctcggtgggg cctgcggacc aaaggtccgc       60

agacggcaga gctctgctct gccggcccca ccgagcgagc gagcgcgcat agagggagtg      120

gccaactcca tcactagggg taccgcgaag cgcctcccac gctgccgcgt cagcgctgac      180

gtaaatcacg tcatagggga gtggtcctgt attagctgtc acgtgagtgc ttttgcgaca      240

ttttgcgaca ccacgtggcc atttgaggta tatatggccg agtgagcgag caggatctcc      300

attttgaccg cgaaatttga acgagcagca gccatgccgg gtttctacga gatcgtgatc      360

aaggtgccga gcgacctgga cgagcacctg ccgggcattt ctgactcgtt tgtgaactgg      420

gtggccgaga aggaatggga gctgcccccg gattctgaca tggatctgaa tctgatcgag      480

caggcacccc tgaccgtggc cgagaagctg cagcgcgact tcctggtcca atggcgccgc      540

gtgagtaagg ccccggaggc cctgttcttt gttcagttcg agaagggcga gagctacttc      600

caccttcacg ttctggtgga gaccacgggg gtcaagtcca tggtgctagg ccgcttcctg      660

agtcagattc gggagaagct ggtccagacc atctaccgcg gggtcgagcc cacgctgccc      720

aactggttcg cggtgaccaa gacgcgtaat ggcgccggcg gggggaacaa ggtggtggac      780

gagtgctaca tccccaacta cctcctgccc aagacccagc ccgagctgca gtgggcgtgg      840

actaacatgg aggagtatat aagcgcgtgt ttgaacctgg ccgaacgcaa acggctcgtg      900

gcgcagcacc tgacccacgt cagccagacg caggagcaga acaaggagaa tctgaacccc      960

aattctgacg cgcccgtgat caggtcaaaa acctccgcgc gctacatgga gctggtcggg     1020

tggctggtgg accggggcat cacctccgag aagcagtgga tccaggagga ccaggcctcg     1080

tacatctcct tcaacgccgc ctccaactcg cggtcccaga tcaaggccgc gctggacaat     1140

gccggcaaga tcatggcgct gaccaaatcc gcgcccgact acctggtggg gccctcgctg     1200

cccgcggaca ttaaaaccaa ccgcatctac cgcatcctgg agctgaacgg gtacgatcct     1260

gcctacgccg gctccgtctt tctcggctgg gcccagaaaa agttcgggaa gcgcaacacc     1320

atctggctgt ttgggcccgc caccaccggc aagaccaaca ttgcggaagc catcgcccac     1380

gccgtgccct tctacggctg cgtcaactgg accaatgaga actttccctt caacgattgc     1440

gtcgacaaga tggtgatctg gtgggaggag ggcaagatga cggccaaggt cgtggagtcc     1500

gccaaggcca ttctcggcgg cagcaaggtg cgcgtggacc aaaagtgcaa gtcgtccgcc     1560

cagatcgacc ccacccccgt gatcgtcacc tccaacacca acatgtgcgc cgtgattgac     1620

gggaacagca ccaccttcga gcaccagcag ccgttgcagg accggatgtt caaatttgaa     1680

ctcacccgcc gtctggagca cgactttggc aaggtgacga agcaggaagt caaagagttc     1740

ttccgctggg ccagtgatca cgtgaccgag gtggcgcatg agttctacgt cagaaagggc     1800

ggagccagca aaagacccgc ccccgatgac gcggatataa gcgagcccaa gcgggcctgc     1860

ccctcagtcg cggatccatc gacgtcagac gcggaaggag ctccggtgga ctttgccgac     1920

aggtaccaaa acaaatgttc tcgtcacgcg ggcatgattc agatgctgtt tccctgcaaa     1980

acgtgcgaga gaatgaatca gaatttcaac atttgcttca cacacggggt cagagactgt     2040

ttagagtgtt tccccggcgt gtcagaatct caaccggtcg tcagaaaaaa gacgtatcgg     2100

aaactctgcg cgattcatca tctgctgggg cgggcgcccg agattgcttg ctcggcctgc     2160

gacctggtca acgtggacct ggacgactgc gtttctgagc aataaatgac ttaaaccagg     2220

tatggctgcc gatggttatc ttccagattg gctcgaggac aacctctctg agggcattcg     2280

cgagtggtgg gacctgaaac ctggagcccc gaaacccaaa gccaaccagc aaaagcagga     2340

caacggccgg ggtctggtgc ttcctggcta caagtacctc ggacccttca acggactcga     2400

caagggggag cccgtcaacg cggcggacgc agcggccctc gagcacgaca aggcctacga     2460

ccagcagctc aaagcgggtg acaatccgta cctgcggtat aaccacgccg acgccgagtt     2520

tcaggagcgt ctgcaagaag atacgtcatt tgggggcaac ctcgggcgag cagtcttcca     2580

ggccaagaag cgggttctcg aacctctcgg tctggttgag gaaggcgcta agacggctcc     2640

tgcaaagaag agaccggtag agccgtcacc tcagcgttcc cccgactcct ccacgggcat     2700

cggcaagaaa ggccagcagc ccgccagaaa gagactcaat ttcggtcaga ctggcgactc     2760

agagtcagtc cccgaccctc aacctctcgg agaacctcca gcagcgccct ctagtgtggg     2820

atctggtaca gtggctgcag gcggtggcgc accaatggca gacaataacg aaggtgccga     2880

cggagtgggt aatgcctcag gaaattggca ttgcgattcc acatggctgg gcgacagagt     2940

cattaccacc agcacccgaa cctgggccct gcccacctac aacaaccacc tctacaagca     3000

aatctccagt gaaactgcag gtagtaccaa cgacaacacc tacttcggct acagcacccc     3060

ctgggggtat tttgacttta acagattcca ctgccacttc tcaccacgtg actggcagcg     3120

actcatcaac aacaactggg gattccggcc caagaagctg cggttcaagc tcttcaacat     3180

ccaggtcaag gaggtcacga cgaatgacgg cgttacgacc atcgctaata accttaccag     3240

cacgattcag gtattctcgg actcggaata ccagctgccg tacgtcctcg gctctgcgca     3300

ccagggctgc ctgcctccgt tcccggcgga cgtcttcatg attcctcagt acggctacct     3360

gactctcaac aatggcagtc agtctgtggg acgttcctcc ttctactgcc tggagtactt     3420

cccctctcag atgctgagaa cgggcaacaa ctttgagttc agctacagct tcgaggacgt     3480

gcctttccac agcagctacg cacacagcca gagcctggac cggctgatga atcccctcat     3540

cgaccagtac ttgtactacc tggccagaac acagagtaac ccaggaggca cagctggcaa     3600

tcgggaactg cagttttacc agggcgggcc ttcaactatg gccgaacaag ccaagaattg     3660

gttacctgga ccttgcttcc ggcaacaaag agtctccaaa acgctggatc aaaacaacaa     3720

cagcaacttt gcttggactg gtgccaccaa atatcacctg aacggcagaa actcgttggt     3780

taatcccggc gtcgccatgg caactcacaa ggacgacgag gaccgctttt tcccatccag     3840

cggagtcctg atttttggaa aaactggagc aactaacaaa actacattgg aaaatgtgtt     3900

aatgacaaat gaagaagaaa ttcgtcctac taatcctgta gccacggaag aatacgggat     3960

agtcagcagc aacttacaag cggctaatac tgcagcccag acacaagttg tcaacaacca     4020

gggagcctta cctggcatgg tctggcagaa ccgggacgtg tacctgcagg gtcccatctg     4080

ggccaagatt cctcacacgg atggcaactt tcacccgtct cctttgatgg gcggctttgg     4140

acttaaacat ccgcctcctc agatcctgat caagaacact cccgttcccg ctaatcctcc     4200

ggaggtgttt actcctgcca agtttgcttc gttcatcaca cagtacagca ccggacaagt     4260

cagcgtggaa atcgagtggg agctgcagaa ggaaaacagc aagcgctgga acccggagat     4320

tcagtacacc tccaactttg aaaagcagac tggtgtggac tttgccgttg acagccaggg     4380

tgtttactct gagcctcgcc ctattggcac tcgttacctc acccgtaatc tgtaattgca     4440

tgttaatcaa taaaccggtt gattcgtttc agttgaactt tggtctcctg tgcttcttat     4500

cttatcggtt tccatagcaa ctggttacac attaactgct tgggtgcgct tcacgataag     4560

aacactgacg tcaccgcggt acccctagtg atggagttgg ccactccctc tatgcgcgct     4620

cgctcgctcg gtggggcctg cggaccaaag gtccgcagac ggcagagctc tgctctgccg     4680

gccccaccga gcgagcgagc gcgcatagag ggagtggcca a                         4721


<210> 5163
<211> 2214
<212> DNA
<213> Adeno-associated virus 7

<400> 5163
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

aacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtcattt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

gcaaagaaga gaccggtaga gccgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctctcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacag tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

attaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccagtg aaactgcagg tagtaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagaagctgc ggttcaagct cttcaacatc      960

caggtcaagg aggtcacgac gaatgacggc gttacgacca tcgctaataa ccttaccagc     1020

acgattcagg tattctcgga ctcggaatac cagctgccgt acgtcctcgg ctctgcgcac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttcctcagta cggctacctg     1140

actctcaaca atggcagtca gtctgtggga cgttcctcct tctactgcct ggagtacttc     1200

ccctctcaga tgctgagaac gggcaacaac tttgagttca gctacagctt cgaggacgtg     1260

cctttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcccctcatc     1320

gaccagtact tgtactacct ggccagaaca cagagtaacc caggaggcac agctggcaat     1380

cgggaactgc agttttacca gggcgggcct tcaactatgg ccgaacaagc caagaattgg     1440

ttacctggac cttgcttccg gcaacaaaga gtctccaaaa cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggcagaaa ctcgttggtt     1560

aatcccggcg tcgccatggc aactcacaag gacgacgagg accgcttttt cccatccagc     1620

ggagtcctga tttttggaaa aactggagca actaacaaaa ctacattgga aaatgtgtta     1680

atgacaaatg aagaagaaat tcgtcctact aatcctgtag ccacggaaga atacgggata     1740

gtcagcagca acttacaagc ggctaatact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggcatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga tggcaacttt cacccgtctc ctttgatggg cggctttgga     1920

cttaaacatc cgcctcctca gatcctgatc aagaacactc ccgttcccgc taatcctccg     1980

gaggtgttta ctcctgccaa gtttgcttcg ttcatcacac agtacagcac cggacaagtc     2040

agcgtggaaa tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatt     2100

cagtacacct ccaactttga aaagcagact ggtgtggact ttgccgttga cagccagggt     2160

gtttactctg agcctcgccc tattggcact cgttacctca cccgtaatct gtaa           2214


<210> 5164
<211> 737
<212> PRT
<213> Adeno-associated virus 7

<400> 5164
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Ala Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Val Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Glu Thr Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Pro Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Glu Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5165
<211> 2217
<212> DNA
<213> Adeno-associated virus 8

<400> 5165
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgca gcagcaaaac acggctcctc aaattggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt     1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa     2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctgtaa        2217


<210> 5166
<211> 2213
<212> DNA
<213> Adeno-associated virus 8

<400> 5166
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgca gcagcaaaac acggctcctc aaattggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt     1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt aatacagaag     2160

gcgtgtactc tgaaccccgc cccattggca cccgttacct cacccgtaat ctg            2213


<210> 5167
<211> 4393
<212> DNA
<213> Adeno-associated virus 8

<400> 5167
cagagaggga gtggccaact ccatcactag gggtagcgcg aagcgcctcc cacgctgccg       60

cgtcagcgct gacgtaaatt acgtcatagg ggagtggtcc tgtattagct gtcacgtgag      120

tgcttttgcg gcattttgcg acaccacgtg gccatttgag gtatatatgg ccgagtgagc      180

gagcaggatc tccattttga ccgcgaaatt tgaacgagca gcagccatgc cgggcttcta      240

cgagatcgtg atcaaggtgc cgagcgacct ggacgagcac ctgccgggca tttctgactc      300

gtttgtgaac tgggtggccg agaaggaatg ggagctgccc ccggattctg acatggatcg      360

gaatctgatc gagcaggcac ccctgaccgt ggccgagaag ctgcagcgcg acttcctggt      420

ccaatggcgc cgcgtgagta aggccccgga ggccctcttc tttgttcagt tcgagaaggg      480

cgagagctac tttcacctgc acgttctggt cgagaccacg ggggtcaagt ccatggtgct      540

aggccgcttc ctgagtcaga ttcgggaaaa gcttggtcca gaccatctac ccgcggggtc      600

gagccccacc ttgcccaact ggttcgcggt gaccaaagac gcggtaatgg cgccggcggg      660

ggggaacaag gtggtggacg agtgctacat ccccaactac ctcctgccca agactcagcc      720

cgagctgcag tgggcgtgga ctaacatgga ggagtatata agcgcgtgct tgaacctggc      780

cgagcgcaaa cggctcgtgg cgcagcacct gacccacgtc agccagacgc aggagcagaa      840

caaggagaat ctgaacccca attctgacgc gcccgtgatc aggtcaaaaa cctccgcgcg      900

ctatatggag ctggtcgggt ggctggtgga ccggggcatc acctccgaga agcagtggat      960

ccaggaggac caggcctcgt acatctcctt caacgccgcc tccaactcgc ggtcccagat     1020

caaggccgcg ctggacaatg ccggcaagat catggcgctg accaaatccg cgcccgacta     1080

cctggtgggg ccctcgctgc ccgcggacat tacccagaac cgcatctacc gcatcctcgc     1140

tctcaacggc tacgaccctg cctacgccgg ctccgtcttt ctcggctggg ctcagaaaaa     1200

gttcgggaaa cgcaacacca tctggctgtt tggacccgcc accaccggca agaccaacat     1260

tgcggaagcc atcgcccacg ccgtgccctt ctacggctgc gtcaactgga ccaatgagaa     1320

ctttcccttc aatgattgcg tcgacaagat ggtgatctgg tgggaggagg gcaagatgac     1380

ggccaaggtc gtggagtccg ccaaggccat tctcggcggc agcaaggtgc gcgtggacca     1440

aaagtgcaag tcgtccgccc agatcgaccc cacccccgtg atcgtcacct ccaacaccaa     1500

catgtgcgcc gtgattgacg ggaacagcac caccttcgag caccagcagc ctctccagga     1560

ccggatgttt aagttcgaac tcacccgccg tctggagcac gactttggca aggtgacaaa     1620

gcaggaagtc aaagagttct tccgctgggc cagtgatcac gtgaccgagg tggcgcatga     1680

gttttacgtc agaaagggcg gagccagcaa aagacccgcc cccgatgacg cggataaaag     1740

cgagcccaag cgggcctgcc cctcagtcgc ggatccatcg acgtcagacg cggaaggagc     1800

tccggtggac tttgccgaca ggtaccaaaa caaatgttct cgtcacgcgg gcatgcttca     1860

gatgctgttt ccctgcaaaa cgtgcgagag aatgaatcag aatttcaaca tttgcttcac     1920

acacggggtc agagactgct cagagtgttt ccccggcgtg tcagaatctc aaccggtcgt     1980

cagaaagagg acgtatcgga aactctgtgc gattcatcat ctgctggggc gggctcccga     2040

gattgcttgc tcggcctgcg atctggtcaa cgtggacctg gatgactgtg tttctgagca     2100

ataaatgact taaaccaggt atggctgccg atggttatct tccagattgg ctcgaggaca     2160

acctctctga gggcattcgc gagtggtggg cgctgaaacc tggagccccg aagcccaaag     2220

ccaaccagca aaagcaggac gacggccggg gtctggtgct tcctggctac aagtacctcg     2280

gacccttcaa cggactcgac aagggggagc ccgtcaacgc ggcggacgca gcggccctcg     2340

agcacgacaa ggcctacgac cagcagctgc aggcgggtga caatccgtac ctgcggtata     2400

accacgccga cgccgagttt caggagcgtc tgcaagaaga tacgtctttt gggggcaacc     2460

tcgggcgagc agtcttccag gccaagaagc gggttctcga acctctcggt ctggttgagg     2520

aaggcgctaa gacggctcct ggaaagaaga gaccggtaga gccatcaccc cagcgttctc     2580

cagactcctc tacgggcatc ggcaagaaag gccaacagcc cgccagaaaa agactcaatt     2640

ttggtcagac tggcgactca gagtcagttc cagaccctca acctctcgga gaacctccag     2700

cagcgccctc tggtgtggga cctaatacaa tggctgcagg cggtggcgca ccaatggcag     2760

acaataacga aggcgccgac ggagtgggta gttcctcggg aaattggcat tgcgattcca     2820

catggctggg cgacagagtc atcaccacca gcacccgaac ctgggccctg cccacctaca     2880

acaaccacct ctacaagcaa atctccaacg ggacatcggg aggagccacc aacgacaaca     2940

cctacttcgg ctacagcacc ccctgggggt attttgactt taacagattc cactgccact     3000

tttcaccacg tgactggcag cgactcatca acaacaactg gggattccgg cccaagagac     3060

tcagcttcaa gctcttcaac atccaggtca aggaggtcac gcagaatgaa ggcaccaaga     3120

ccatcgccaa taacctcacc agcaccatcc aggtgtttac ggactcggag taccagctgc     3180

cgtacgttct cggctctgcc caccagggct gcctgcctcc gttcccggcg gacgtgttca     3240

tgattcccca gtacggctac ctaacactca acaacggtag tcaggccgtg ggacgctcct     3300

ccttctactg cctggaatac tttccttcgc agatgctgag aaccggcaac aacttccagt     3360

ttacttacac cttcgaggac gtgcctttcc acagcagcta cgcccacagc cagagcttgg     3420

accggctgat gaatcctctg attgaccagt acctgtacta cttgtctcgg actcaaacaa     3480

caggaggcac ggcaaatacg cagactctgg gcttcagcca aggtgggcct aatacaatgg     3540

ccaatcaggc aaagaactgg ctgccaggac cctgttaccg ccaacaacgc gtctcaacga     3600

caaccgggca aaacaacaat agcaactttg cctggactgc tgggaccaaa taccatctga     3660

atggaagaaa ttcattggct aatcctggca tcgctatggc aacacacaaa gacgacgagg     3720

agcgtttttt tcccagtaac gggatcctga tttttggcaa acaaaatgct gccagagaca     3780

atgcggatta cagcgatgtc atgctcacca gcgaggaaga aatcaaaacc actaaccctg     3840

tggctacaga ggaatacggt atcgtggcag ataacttgca gcagcaaaac acggctcctc     3900

aaattggaac tgtcaacagc cagggggcct tacccggtat ggtctggcag aaccgggacg     3960

tgtacctgca gggtcccatc tgggccaaga ttcctcacac ggacggcaac ttccacccgt     4020

ctccgctgat gggcggcttt ggcctgaaac atcctccgcc tcagatcctg atcaagaaca     4080

cgcctgtacc tgcggatcct ccgaccacct tcaaccagtc aaagctgaac tctttcatca     4140

cgcaatacag caccggacag gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca     4200

gcaagcgctg gaaccccgag atccagtaca cctccaacta ctacaaatct acaagtgtgg     4260

actttgctgt taatacagaa ggcgtgtact ctgaaccccg ccccattggc acccgttacc     4320

tcacccgtaa tctgtaattg cctgttaatc aataaaccgg ttgattcgtt tcagttgaac     4380

tttggtctct gcg                                                        4393


<210> 5168
<211> 738
<212> PRT
<213> Adeno-associated virus 8

<400> 5168
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5169
<211> 737
<212> PRT
<213> Adeno-associated virus 8

<400> 5169
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Ile Gln Lys 
705                 710                 715                 720 


Ala Cys Thr Leu Asn Pro Ala Pro Leu Ala Pro Val Thr Ser Pro Val 
                725                 730                 735     


Ile 
    


<210> 5170
<211> 2217
<212> DNA
<213> Adeno-associated virus 8

<400> 5170
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgca gcagcaaaac acggctcctc aaattggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt     1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa     2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctgtaa        2217


<210> 5171
<211> 4385
<212> DNA
<213> Adeno-associated virus 9

<400> 5171
cagagaggga gtggccaact ccatcactag gggtaatcgc gaagcgcctc ccacgctgcc       60

gcgtcagcgc tgacgtagat tacgtcatag gggagtggtc ctgtattagc tgtcacgtga      120

gtgcttttgc gacattttgc gacaccacat ggccatttga ggtatatatg gccgagtgag      180

cgagcaggat ctccattttg accgcgaaat ttgaacgagc agcagccatg ccgggcttct      240

acgagattgt gatcaaggtg ccgagcgacc tggacgagca cctgccgggc atttctgact      300

cttttgtgaa ctgggtggcc gagaaggaat gggagctgcc cccggattct gacatggatc      360

ggaatctgat cgagcaggca cccctgaccg tggccgagaa gctgcagcgc gacttcctgg      420

tccaatggcg ccgcgtgagt aaggccccgg aggccctctt ctttgttcag ttcgagaagg      480

gcgagagcta ctttcacctg cacgttctgg tcgagaccac gggggtcaag tccatggtgc      540

taggccgctt cctgagtcag attcgggaga agctggtcca gaccatctac cgcgggatcg      600

agccgaccct gcccaactgg ttcgcggtga ccaagacgcg taatggcgcc ggcgggggga      660

acaaggtggt ggacgagtgc tacatcccca actacctcct gcccaagact cagcccgagc      720

tgcagtgggc gtggactaac atggaggagt atataagcgc gtgcttgaac ctggccgagc      780

gcaaacggct cgtggcgcag cacctgaccc acgtcagcca gacgcaggag cagaacaagg      840

agaatctgaa ccccaattct gacgcgcccg tgatcaggtc aaaaacctcc gcgcgctaca      900

tggagctggt cgggtggctg gtggaccggg gcatcacctc cgagaagcag tggatccagg      960

aggaccaggc ctcgtacatc tccttcaacg ccgcctccaa ctcgcggtcc cagatcaagg     1020

ccgcgctgga caatgccggc aagatcatgg cgctgaccaa atccgcgccc gactacctgg     1080

taggcccttc acttccggtg gacattacgc agaaccgcat ctaccgcatc ctgcagctca     1140

acggctacga ccctgcctac gccggctccg tctttctcgg ctgggcacaa aagaagttcg     1200

ggaaacgcaa caccatctgg ctgtttgggc cggccaccac gggaaagacc aacatcgcag     1260

aagccattgc ccacgccgtg cccttctacg gctgcgtcaa ctggaccaat gagaactttc     1320

ccttcaacga ttgcgtcgac aagatggtga tctggtggga ggagggcaag atgacggcca     1380

aggtcgtgga gtccgccaag gccattctcg gcggcagcaa ggtgcgcgtg gaccaaaagt     1440

gcaagtcgtc cgcccagatc gaccccactc ccgtgatcgt cacctccaac accaacatgt     1500

gcgccgtgat tgacgggaac agcaccacct tcgagcacca gcagcctctc caggaccgga     1560

tgtttaagtt cgaactcacc cgccgtctgg agcacgactt tggcaaggtg acaaagcagg     1620

aagtcaaaga gttcttccgc tgggccagtg atcacgtgac cgaggtggcg catgagtttt     1680

acgtcagaaa gggcggagcc agcaaaagac ccgcccccga tgacgcggat aaaagcgagc     1740

ccaagcgggc ctgcccctca gtcgcggatc catcgacgtc agacgcggaa ggagctccgg     1800

tggactttgc cgacaggtac caaaacaaat gttctcgtca cgcgggcatg cttcagatgc     1860

tgcttccctg caaaacgtgc gagagaatga atcagaattt caacatttgc ttcacacacg     1920

gggtcagaga ctgctcagag tgtttccccg gcgtgtcaga atctcaaccg gtcgtcagaa     1980

agaggacgta tcggaaactc tgtgcgattc atcatctgct ggggcgggct cccgagattg     2040

cttgctcggc ctgcgatctg gtcaacgtgg acctggatga ctgtgtttct gagcaataaa     2100

tgacttaaac caggtatggc tgccgatggt tatcttccag attggctcga ggacaacctc     2160

tctgagggca ttcgcgagtg gtgggcgctg aaacctggag ccccgaagcc caaagccaac     2220

cagcaaaagc aggacgacgg ccggggtctg gtgcttcctg gctacaagta cctcggaccc     2280

ttcaacggac tcgacaaggg ggagcccgtc aacgcggcgg acgcagcggc cctcgagcac     2340

ggcaaggcct acgaccagca gctgcaggcg ggtgacaatc cgtacctgcg gtataaccac     2400

gccgacgccg agtttcagga gcgtctgcaa gaagatacgt cttttggggg caacctcggg     2460

cgagcagtct tccaggccaa gaagcgggtt ctcgaacctc tcggtctggt tgaggaaggc     2520

gctaagacgg ctcctggaaa gaagagaccg gtagagccat caccccagcg ttctccagac     2580

tcctctacgg gcatcggcaa gaaaggccaa cagcccgcca gaaaaagact caattttggt     2640

cagactggcg actcagagtc agttccagac cctcaacctc tcggagaacc tccagcagcg     2700

ccctctggtg tgggacctaa tacaatggct gcaggcggtg gcgcaccaat ggcagacaat     2760

aacgaaggcg ccgacggagt gggtaattcc tcgggaaatt ggcattgcga ttccacatgg     2820

ctgggggaca gagtcatcac caccagcacc cgaacctggg cattgcccac ctacaacaac     2880

cacctctaca agcaaatctc caatggaaca tcgggaggaa gcaccaacga caacacctac     2940

tttggctaca gcaccccctg ggggtatttt gacttcaaca gattccactg ccacttctca     3000

ccacgtgact ggcagcgact catcaacaac aactggggat tccggccaaa gagactcaac     3060

ttcaagctgt tcaacatcca ggtcaaggag gttacgacga acgaaggcac caagaccatc     3120

gccaataacc ttaccagcac cgtccaggtc tttacggact cggagtacca gctaccgtac     3180

gtcctaggct ctgcccacca aggatgcctg ccaccgtttc ctgcagacgt cttcatggtt     3240

cctcagtacg gctacctgac gctcaacaat ggaagtcaag cgttaggacg ttcttctttc     3300

tactgtctgg aatacttccc ttctcagatg ctgagaaccg gcaacaactt tcagttcagc     3360

tacactttcg aggacgtgcc tttccacagc agctacgcac acagccagag tctagatcga     3420

ctgatgaacc ccctcatcga ccagtaccta tactacctgg tcagaacaca gacaactgga     3480

actgggggaa ctcaaacttt ggcattcagc caagcaggcc ctagctcaat ggccaatcag     3540

gctagaaact gggtacccgg gccttgctac cgtcagcagc gcgtctccac aaccaccaac     3600

caaaataaca acagcaactt tgcgtggacg ggagctgcta aattcaagct gaacgggaga     3660

gactcgctaa tgaatcctgg cgtggctatg gcatcgcaca aagacgacga ggaccgcttc     3720

tttccatcaa gtggcgttct catatttggc aagcaaggag ccgggaacga tggagtcgac     3780

tacagccagg tgctgattac agatgaggaa gaaattaaag ccaccaaccc tgtagccaca     3840

gaggaatacg gagcagtggc catcaacaac caggccgcta acacgcaggc gcaaactgga     3900

cttgtgcata accagggagt tattcctggt atggtctggc agaaccggga cgtgtacctg     3960

cagggcccta tttgggctaa aatacctcac acagatggca actttcaccc gtctcctctg     4020

atgggtggat ttggactgaa acacccacct ccacagattc taattaaaaa tacaccagtg     4080

ccggcagatc ctcctcttac cttcaatcaa gccaagctga actctttcat cacgcagtac     4140

agcacgggac aagtcagcgt ggaaatcgag tgggagctgc agaaagaaaa cagcaagcgc     4200

tggaatccag agatccagta tacttcaaac tactacaaat ctacaaatgt ggactttgct     4260

gtcaatacca aaggtgttta ctctgagcct cgccccattg gtactcgtta cctcacccgt     4320

aatttgtaat tgcctgttaa tcaataaacc ggttaattcg tttcagttga actttggtct     4380

ctgcg                                                                 4385


<210> 5172
<211> 4382
<212> DNA
<213> Adeno-associated virus 9

<400> 5172
cagagaggga gtggccaact ccatcactag gggtaatcgc gaagcgcctc ccacgctgcc       60

gcgtcagcgc tgacgtagat tacgtcatag gggagtggtc ctgtattagc tgtcacgtga      120

gtgcttttgc gacattttgc gacaccacat ggccatttga ggtatatatg gccgagtgag      180

cgagcaggat ctccattttg accgcgaaat ttgaacgagc agcagccatg ccgggcttct      240

acgagattgt gatcaaggtg ccgagcgacc tggacgagca cctgccgggc atttctgact      300

cttttgtgaa ctgggtggcc gagaaggaat gggagctgcc cccggattct gacatggatc      360

ggaatctgat cgagcaggca cccctgaccg tggccgagaa gctgtagcgc gacttcctgg      420

tccaatggcg ccgcgtgagt aaggccccgg aggccctctt ctttgttcag ttcgagaagg      480

gcgagagcta ctttcacctg cacgttctgg tcgagaccac gggggtcaag tccatggtgc      540

taggccgctt cctgagtcag attcgggaga agctggtcca gaccatctac cgcgggatcg      600

agccgaccct gcccaactgg ttcgcggtga ccaagacgcg taatggcgcc ggcgggggga      660

acaaggtggt ggacgagtgc tacatcccca actacctcct gcccaagact cagcccgagc      720

tgcagtgggc gtggactaac atggaggagt atataagcgc gtgcttgaac ctggccgagc      780

gcaaacggct cgtggcgcag cacctgaccc acgtcagcca gacgcaggag cagaacaagg      840

agaatctgaa ccccaattct gacgcgcccg tgatcaggtc aaaaacctcc gcgcgctaca      900

tggagctggt cgggtggctg gtggaccggg gcatcacctc cgagaagcag tggatccagg      960

aggaccaggc ctcgtacatc tccttcaacg ccgcctccaa ctcgcggtcc cagatcaagg     1020

ccgcgctgga caatgccggc aagatcatgg cgctgaccaa atccgcgccc gactacctgg     1080

taggcccttc acttccggtg gacattacgc agaaccgcat ctaccgcatc ctgcagctca     1140

acggctacga ccctgcctac gccggctccg tctttctcgg ctgggcacaa aagaagttcg     1200

ggaaacgcaa caccatctgg ctgtttgggc cggccaccac gggaaagacc aacatcgcag     1260

aagccattgc ccacgccgtg cccttctacg gctgcgtcaa ctggaccaat gagaactttc     1320

ccttcaacga ttgcgtcgac aagatggtga tctggtggga ggagggcaag atgacggcca     1380

aggtcgtgga gtccgccaag gccattctcg gcggcagcaa ggtgcgcgtg gaccaaaagt     1440

gcaagtcgtc cgcccagatc gaccccactc ccgtgatcgt cacctccaac accaacatgt     1500

gcgccgtgat tgacgggaac agcaccacct tcgagcacca gcagcctctc caggaccgga     1560

tgtttaagtt cgaactcacc cgccgtctgg agcacgactt tggcaaggtg acaaagcagg     1620

aagtcaaaga gttcttccgc tgggccagtg atcacgtgac cgaggtggcg catgagtttt     1680

acgtcagaaa gggcggagcc agcaaaagac ccgcccccga tgacgcggat aaaagcgagc     1740

ccaagcgggc ctgcccctca gtcgcggatc catcgacgtc agacgcggaa ggagctccgg     1800

tggactttgc cgacaggtac caaaacaaat gttctcgtca cgcgggcatg cttcagatgc     1860

tgcttccctg caaaacgtgc gagagaatga atcagaattt caacatttgc ttcacacacg     1920

gggtcagaga ctgctcagag tgtttccccg gcgtgtcaga atctcaaccg gtcgtcagaa     1980

agaggacgta tcggaaactc tgtgcgattc atcatctgct ggggcgggct cccgagattg     2040

cttgctcggc ctgcgatctg gtcaacgtgg acctggatga ctgtgtttct gagcaataaa     2100

tgacttaaac caggtatggc tgccgatggt tatcttccag attggctcga ggacaacctc     2160

tctgagggca ttcgcgagtg gtgggacctg aaacctggag ccccgaaacc caaagccaac     2220

cagcaaaagc aggacgacgg ccggggtctg gtgcttcctg gctacaagta cctcggaccc     2280

ttcaacggac tcgacaaggg ggagcccgtc aacgcggcgg acgcagcggc cctcgagcac     2340

gacaaggcct acgaccagca gctcaaagcg ggtgacaatc cgtacctgcg gtataaccac     2400

gccgacgccg agtttcagga gcgtctgcaa gaagatacgt cttttggggg caacctcggg     2460

cgagcagtct tccaggccaa gaagcgggtt ctcgaacctc tcggtctggt tgaggaaggc     2520

gctaagacgg ctcctggaaa gaagagaccg gtagagcagt caccccaaga accagactca     2580

tcctcgggca tcggcaaatc aggccagcag cccgctaaaa agagactcaa ttttggtcag     2640

actggcgact cagagtcagt ccccgaccca caacctctcg gagaacctcc agaagccccc     2700

tcaggtctgg gacctaatac aatggcttca ggcggtggcg ctccaatggc agacaataac     2760

gaaggcgccg acggagtggg taattcctcg ggaaattggc attgcgattc cacatggctg     2820

ggggacagag tcatcaccac cagcacccga acctgggcat tgcccaccta caacaaccac     2880

ctctacaagc aaatctccaa tggaacatcg ggaggaagca ccaacgacaa cacctacttt     2940

ggctacagca ccccctgggg gtattttgac ttcaacagat tccactgcca cttctcacca     3000

cgtgactggc agcgactcat caacaacaac tggggattcc ggccaaagag actcaacttc     3060

aagctgttca acatccaggt caaggaggtt acgacgaacg aaggcaccaa gaccatcgcc     3120

aataacctta ccagcaccgt ccaggtcttt acggactcgg agtaccagct accgtacgtc     3180

ctaggctctg cccaccaagg atgcctgcca ccgtttcctg cagacgtctt catggttcct     3240

cagtacggct acctgacgct caacaatgga agtcaagcgt taggacgttc ttctttctac     3300

tgtctggaat acttcccttc tcagatgctg agaaccggca acaactttca gttcagctac     3360

actttcgagg acgtgccttt ccacagcagc tacgcacaca gccagagtct agatcgactg     3420

atgaaccccc tcatcgacca gtacctatac tacctggtca gaacacagac aactggaact     3480

gggggaactc aaactttggc attcagccaa gcaggcccta gctcaatggc caatcaggct     3540

agaaactggg tacccgggcc ttgctaccgt cagcagcgcg tctccacaac caccaaccaa     3600

aataacaaca gcaactttgc gtggacggga gctgctaaat tcaagctgaa cgggagagac     3660

tcgctaatga atcctggcgt ggctatggca tcgcacaaag acgacgagga ccgcttcttt     3720

ccatcaagtg gcgttctcat atttggcaag caaggagccg ggaacgatgg agtcgactac     3780

agccaggtgc tgattacaga tgaggaagaa attaaagcca ccaaccctgt agccacagag     3840

gaatacggag cagtggccat caacaaccag gccgctaaca cgcaggcgca aactggactt     3900

gtgcataacc agggagttat tcctggtatg gtctggcaga accgggacgt gtacctgcag     3960

ggccctattt gggctaaaat acctcacaca gatggcaact ttcacccgtc tcctctgatg     4020

ggtggatttg gactgaaaca cccacctcca cagattctaa ttaaaaatac accagtgccg     4080

gcagatcctc ctcttacctt caatcaagcc aagctgaact ctttcatcac gcagtacagc     4140

acgggacaag tcagcgtgga aatcgagtgg gagctgcaga aagaaaacag caagcgctgg     4200

aatccagaga tccagtatac ttcaaactac tacaaatcta caaatgtgga ctttgctgtc     4260

aataccgaag gtgtttactc tgagcctcgc cccattggta ctcgttacct cacccgtaat     4320

ttgtaattgc ctgttaatca ataaaccggt taattcgttt cagttgaact ttggtctctg     4380

cg                                                                    4382


<210> 5173
<211> 736
<212> PRT
<213> Adeno-associated virus 9

<400> 5173
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5174
<211> 736
<212> PRT
<213> Adeno-associated virus 9

<400> 5174
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Glu Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5175
<211> 623
<212> PRT
<213> Adeno-associated virus 9

<400> 5175
Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Arg Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Val Gln Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Leu His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Val Gln Thr Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Glu Tyr Ile 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Leu Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ala Leu Thr Lys Ser Ala Pro Asp Tyr Leu Val Gly Pro Ser 
        275                 280                 285             


Leu Pro Val Asp Ile Thr Gln Asn Arg Ile Tyr Arg Ile Leu Gln Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Ala Tyr Ala Gly Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Glu Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
465                 470                 475                 480 


Ala His Glu Phe Tyr Val Arg Lys Gly Gly Ala Ser Lys Arg Pro Ala 
                485                 490                 495     


Pro Asp Asp Ala Asp Lys Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
            500                 505                 510         


Ala Asp Pro Ser Thr Ser Asp Ala Glu Gly Ala Pro Val Asp Phe Ala 
        515                 520                 525             


Asp Arg Tyr Gln Asn Lys Cys Ser Arg His Ala Gly Met Leu Gln Met 
    530                 535                 540                 


Leu Leu Pro Cys Lys Thr Cys Glu Arg Met Asn Gln Asn Phe Asn Ile 
545                 550                 555                 560 


Cys Phe Thr His Gly Val Arg Asp Cys Ser Glu Cys Phe Pro Gly Val 
                565                 570                 575     


Ser Glu Ser Gln Pro Val Val Arg Lys Arg Thr Tyr Arg Lys Leu Cys 
            580                 585                 590         


Ala Ile His His Leu Leu Gly Arg Ala Pro Glu Ile Ala Cys Ser Ala 
        595                 600                 605             


Cys Asp Leu Val Asn Val Asp Leu Asp Asp Cys Val Ser Glu Gln 
    610                 615                 620             


<210> 5176
<211> 1797
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5176
acggctccga ccggagacaa gcggaaaggc gaagacgaac ctcgtttgcc cgacacttct       60

tcacagactc ccaagaaaaa caagaagcct cgcaaggaaa gaccttccgg cggggcagaa      120

gatccgggcg aaggcacctc ttccaacgct ggagcagcag cacccgcctc tagtgtggga      180

tcatctatca tggctgaagg aggtggcggc ccagtgggcg atgcaggcca gggtgccgat      240

ggagtgggca attcctccgg aaattggcat tgcgattccc aatggctgga aaacggagtc      300

gtcactcgaa ccacccgaac ctgggtcttg cccagctaca acaaccacct gtacaaacga      360

atccaaggac ccagcggagg cgacaacaac aacaaattct ttggattcag caccccctgg      420

ggatactttg actacaatcg attccactgc cacttttccc cgcgagactg gcaacgactc      480

atcaacaaca actggggcat ccgtcccaaa gcgatgcgct ttagactctt taacatccag      540

gttaaagagg tcacggtcca agacttcaac accaccatcg gcaacaacct caccagtacg      600

gtccaggtct ttgcggacaa ggactaccaa ctgccgtacg tcctcggatc ggctaccgaa      660

ggcaccttcc cgccgttccc agcggatatc tacacgatcc cgcagtacgg gtactgcacg      720

ctaaactaca acaacgaggc ggtggatcgt tcggccttct actgtctgga ctactttccc      780

tcagacatgc tgcggacagg aaataacttt gagtttactt acaccttcga ggacgttcct      840

ttccatagca tgtttgccca caaccagacg ctagaccggc tgatgaatcc cctcgtggat      900

cagtacctct gggctttcag ctccgtcagc caagcaggct catctggacg agctcttcat      960

tactcgcggg cgactaaaac caacatggcg gctcaatata ggaactggtt acctgggcct     1020

ttcttccgtg atcagcaaat ctttacgggc gctagcaaca tcactaaaaa taacgtcttt     1080

agcgtttggg aaaaaggcaa gcaatgggaa ctcgacaatc ggaccaacct aatgcagccc     1140

ggtcctgcgg cagcgaccac ctttagcgga gaacctgacc gtcaagccat gcaaaacacg     1200

ctggctttta gcaggaccgt ctacgatcaa acgaccgcca cgaccgatcg taaccagata     1260

ctcatcacca acgaagacga aatcagaccc accaactcgg tcggtatcga cgcgtgggga     1320

gcagttccca ccaacaacca gtcgatcgtg acccccggca ctcgcgcggc cgtcaacaat     1380

caaggggcgc ttcccgggat ggtgtggcaa aacagagaca tttaccctac agggacccat     1440

ttggccaaaa ttcccgacac tgacaatcac ttccatccgt ccccgcttat tgggcggttt     1500

ggctgcaagc atccccctcc ccagattttc attaaaaaca cacccgtccc tgccaaccct     1560

tcggaaacgt tccagacggc caaagtggcc tccttcatca accagtactc gaccggacag     1620

tgcaccgtcg aaatcttttg ggaactcaag aaggaaacct ccaagcgctg gaaccccgaa     1680

atccagttca cctccaactt tggcaacgcg gccgacatcc agtttgccgt ctccgacacg     1740

ggatcctatt ccgaacctcg tcccatcggt acccgttacc ttaccaaacc tctgtaa        1797


<210> 5177
<211> 1989
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5177
atgaggtcgt actacgaggt catcgttcag ctgcccaacg acgtcgagag tcaggtacct       60

ggaatctccg attcgttcgt caactggatt acgtcgcgag aatggacgtt gcctgaggac      120

gccgattggg atttggacca ggtcgatcaa gttcaactga cgctcggcga caaaatccaa      180

cgggagattc gaactcattg ggggacgatg gccaaagaac cggactttca ctattttatc      240

caactggaac aaggtgaggt gttctttcat ttacacgtcc tgctggaaac gtgttccgta      300

aagccgatgg tactcggaag atatatccga catattcaac aaaaaattgt gagtaaagtc      360

tactgcgcca cgagcctacg atggaaggat ggatgcgtgg tgaccaagac caaaaatttc      420

gggggcgcga acaaggtccg ggccgagtcg tatattcccg cctacctgat cccgaaacag      480

caaccggaag tgcagtgggc gtggactaac gtgcccgagt atataaaagc gtgcttgcac      540

cgagaactgc gtgccagtct cgcgcgactt cacttcgagg aggcgggcgt ctcgcaatcc      600

aaggaaaatc tcgcgagaac tgcagacggc gctcccgtga tgccgacccg cgtcagcaaa      660

cgctacatgg agctcgtgga ttggctcgtg gagaagggga tcaccaccga gaaggaatgg      720

ctgctggaaa acagagaaag ctttcggagc tttcaggcct cgagcaactc ggcgcgtcag      780

atcaagacgg ccctgcaagg cgccattcag gagatgcttc tgaccaagac ggcggaggac      840

tacctcgtcg gaaaggatcc cgtctcggac gacgacatcc gtcagaaccg catctacaag      900

attctggaac tgaaccacta cgacccagcg tacgtgggga gtattttggt cgggtggtgc      960

cagaagaaat ggggcaagcg aaacacgctg tggctgttcg gacatgcgac caccggcaag     1020

accaacatcg cggaggctat tgcccatgct gtgccgttct atggatgcgt taactggacc     1080

aacgagaact ttccgttcaa cgactgcgtc gaaaaaatga ttatctggtg ggaggagggc     1140

aaaatgaccg ccaaagtggt ggaaacagcc aaggcgattc tgggaggatc tcgggtgaga     1200

gtggaccaaa aatgcaaagc ttcggttccg atcgaaccga cgccggtcat tattaccagt     1260

aacaccaaca tgtgttatgt catcgacggg aacacgacca cgttcgagca taagcagccg     1320

ttggaggaca ggatgtttaa gctcgaattg ctgactcggt tgcctgatga ctttggtaag     1380

gtgaccaaac aggaggtgcg tcaattcttc aggtggtctc aggatcacct gacccctgtg     1440

atcccagaat tcctagtgcg gaaggcggag tctcgcaaaa gacccgcccc ttccggggaa     1500

ggctatataa gcccgacaaa gcggcccgcg ctcgcagagc agcagcaggc gtcggagagc     1560

gcggacccgg ttcccaccag gtatcgtatc aaatgctcga aacattgcgg tatggataaa     1620

atgttgtttc cttgccaaat ttgtgaatcg atgaacagag atattaatat ttgtgctatt     1680

cataaaacga ccgactgtaa agagtgtttc cccgactacg gggataaaga tgatgtagaa     1740

ctacccccct gtacagaaca caacgtgtct cgttgttatc aatgtcattc gggcgaattg     1800

tatcgcgtga cttcggactc tgacgagaaa cctgcccccg agagtgatga aggcaccgag     1860

ccatcctatg ctccctgcac gattcaccac ctgatgggca agagtcacgg gttagtcact     1920

tgcgcggcgt gtcggttgaa aaatagtacg ttgcatgatg acttggatga cggtgatctc     1980

gaacaataa                                                             1989


<210> 5178
<211> 1626
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5178
atgaggtcgt actacgaggt catcgttcag ctgcccaacg acgtcgagag tcaggtacct       60

ggaatctccg attcgttcgt caactggatt acgtcgcgag aatggacgtt gcctgaggac      120

gccgattggg atttggacca ggtcgatcaa gttcaactga cgctcggcga caaaatccaa      180

cgggagattc gaactcattg ggggacgatg gccaaagaac cggactttca ctattttatc      240

caactggaac aaggtgaggt gttctttcat ttacacgtcc tgctggaaac gtgttccgta      300

aagccgatgg tactcggaag atatatccga catattcaac aaaaaattgt gagtaaagtc      360

tactgcgcca cgagcctacg atggaaggat ggatgcgtgg tgaccaagac caaaaatttc      420

gggggcgcga acaaggtccg ggccgagtcg tatattcccg cctacctgat cccgaaacag      480

caaccggaag tgcagtgggc gtggactaac gtgcccgagt atataaaagc gtgcttgcac      540

cgagaactgc gtgccagtct cgcgcgactt cacttcgagg aggcgggcgt ctcgcaatcc      600

aaggaaaatc tcgcgagaac tgcagacggc gctcccgtga tgccgacccg cgtcagcaaa      660

cgctacatgg agctcgtgga ttggctcgtg gagaagggga tcaccaccga gaaggaatgg      720

ctgctggaaa acagagaaag ctttcggagc tttcaggcct cgagcaactc ggcgcgtcag      780

atcaagacgg ccctgcaagg cgccattcag gagatgcttc tgaccaagac ggcggaggac      840

tacctcgtcg gaaaggatcc cgtctcggac gacgacatcc gtcagaaccg catctacaag      900

attctggaac tgaaccacta cgacccagcg tacgtgggga gtattttggt cgggtggtgc      960

cagaagaaat ggggcaagcg aaacacgctg tggctgttcg gacatgcgac caccggcaag     1020

accaacatcg cggaggctat tgcccatgct gtgccgttct atggatgcgt taactggacc     1080

aacgagaact ttccgttcaa cgactgcgtc gaaaaaatga ttatctggtg ggaggagggc     1140

aaaatgaccg ccaaagtggt ggaaacagcc aaggcgattc tgggaggatc tcgggtgaga     1200

gtggaccaaa aatgcaaagc ttcggttccg atcgaaccga cgccggtcat tattaccagt     1260

aacaccaaca tgtgttatgt catcgacggg aacacgacca cgttcgagca taagcagccg     1320

ttggaggaca ggatgtttaa gctcgaattg ctgactcggt tgcctgatga ctttggtaag     1380

gtgaccaaac aggaggtgcg tcaattcttc aggtggtctc aggatcacct gacccctgtg     1440

atcccagaat tcctagtgcg gaaggcggag tctcgcaaaa gacccgcccc ttccggggaa     1500

ggctatataa gcccgacaaa gcggcccgcg ctcgcagagc agcagcaggc gtcggagagc     1560

gcggacccgg ttcccaccag attggttgga gcggttggtc aaaaagggag tgaatgctgc     1620

agctga                                                                1626


<210> 5179
<211> 1323
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5179
atggagctcg tggattggct cgtggagaag gggatcacca ccgagaagga atggctgctg       60

gaaaacagag aaagctttcg gagctttcag gcctcgagca actcggcgcg tcagatcaag      120

acggccctgc aaggcgccat tcaggagatg cttctgacca agacggcgga ggactacctc      180

gtcggaaagg atcccgtctc ggacgacgac atccgtcaga accgcatcta caagattctg      240

gaactgaacc actacgaccc agcgtacgtg gggagtattt tggtcgggtg gtgccagaag      300

aaatggggca agcgaaacac gctgtggctg ttcggacatg cgaccaccgg caagaccaac      360

atcgcggagg ctattgccca tgctgtgccg ttctatggat gcgttaactg gaccaacgag      420

aactttccgt tcaacgactg cgtcgaaaaa atgattatct ggtgggagga gggcaaaatg      480

accgccaaag tggtggaaac agccaaggcg attctgggag gatctcgggt gagagtggac      540

caaaaatgca aagcttcggt tccgatcgaa ccgacgccgg tcattattac cagtaacacc      600

aacatgtgtt atgtcatcga cgggaacacg accacgttcg agcataagca gccgttggag      660

gacaggatgt ttaagctcga attgctgact cggttgcctg atgactttgg taaggtgacc      720

aaacaggagg tgcgtcaatt cttcaggtgg tctcaggatc acctgacccc tgtgatccca      780

gaattcctag tgcggaaggc ggagtctcgc aaaagacccg ccccttccgg ggaaggctat      840

ataagcccga caaagcggcc cgcgctcgca gagcagcagc aggcgtcgga gagcgcggac      900

ccggttccca ccaggtatcg tatcaaatgc tcgaaacatt gcggtatgga taaaatgttg      960

tttccttgcc aaatttgtga atcgatgaac agagatatta atatttgtgc tattcataaa     1020

acgaccgact gtaaagagtg tttccccgac tacggggata aagatgatgt agaactaccc     1080

ccctgtacag aacacaacgt gtctcgttgt tatcaatgtc attcgggcga attgtatcgc     1140

gtgacttcgg actctgacga gaaacctgcc cccgagagtg atgaaggcac cgagccatcc     1200

tatgctccct gcacgattca ccacctgatg ggcaagagtc acgggttagt cacttgcgcg     1260

gcgtgtcggt tgaaaaatag tacgttgcat gatgacttgg atgacggtga tctcgaacaa     1320

taa                                                                   1323


<210> 5180
<211> 960
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5180
atggagctcg tggattggct cgtggagaag gggatcacca ccgagaagga atggctgctg       60

gaaaacagag aaagctttcg gagctttcag gcctcgagca actcggcgcg tcagatcaag      120

acggccctgc aaggcgccat tcaggagatg cttctgacca agacggcgga ggactacctc      180

gtcggaaagg atcccgtctc ggacgacgac atccgtcaga accgcatcta caagattctg      240

gaactgaacc actacgaccc agcgtacgtg gggagtattt tggtcgggtg gtgccagaag      300

aaatggggca agcgaaacac gctgtggctg ttcggacatg cgaccaccgg caagaccaac      360

atcgcggagg ctattgccca tgctgtgccg ttctatggat gcgttaactg gaccaacgag      420

aactttccgt tcaacgactg cgtcgaaaaa atgattatct ggtgggagga gggcaaaatg      480

accgccaaag tggtggaaac agccaaggcg attctgggag gatctcgggt gagagtggac      540

caaaaatgca aagcttcggt tccgatcgaa ccgacgccgg tcattattac cagtaacacc      600

aacatgtgtt atgtcatcga cgggaacacg accacgttcg agcataagca gccgttggag      660

gacaggatgt ttaagctcga attgctgact cggttgcctg atgactttgg taaggtgacc      720

aaacaggagg tgcgtcaatt cttcaggtgg tctcaggatc acctgacccc tgtgatccca      780

gaattcctag tgcggaaggc ggagtctcgc aaaagacccg ccccttccgg ggaaggctat      840

ataagcccga caaagcggcc cgcgctcgca gagcagcagc aggcgtcgga gagcgcggac      900

ccggttccca ccagattggt tggagcggtt ggtcaaaaag ggagtgaatg ctgcagctga      960


<210> 5181
<211> 1608
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5181
atggctgaag gaggtggcgg cccagtgggc gatgcaggcc agggtgccga tggagtgggc       60

aattcctccg gaaattggca ttgcgattcc caatggctgg aaaacggagt cgtcactcga      120

accacccgaa cctgggtctt gcccagctac aacaaccacc tgtacaaacg aatccaagga      180

cccagcggag gcgacaacaa caacaaattc tttggattca gcaccccctg gggatacttt      240

gactacaatc gattccactg ccacttttcc ccgcgagact ggcaacgact catcaacaac      300

aactggggca tccgtcccaa agcgatgcgc tttagactct ttaacatcca ggttaaagag      360

gtcacggtcc aagacttcaa caccaccatc ggcaacaacc tcaccagtac ggtccaggtc      420

tttgcggaca aggactacca actgccgtac gtcctcggat cggctaccga aggcaccttc      480

ccgccgttcc cagcggatat ctacacgatc ccgcagtacg ggtactgcac gctaaactac      540

aacaacgagg cggtggatcg ttcggccttc tactgtctgg actactttcc ctcagacatg      600

ctgcggacag gaaataactt tgagtttact tacaccttcg aggacgttcc tttccatagc      660

atgtttgccc acaaccagac gctagaccgg ctgatgaatc ccctcgtgga tcagtacctc      720

tgggctttca gctccgtcag ccaagcaggc tcatctggac gagctcttca ttactcgcgg      780

gcgactaaaa ccaacatggc ggctcaatat aggaactggt tacctgggcc tttcttccgt      840

gatcagcaaa tctttacggg cgctagcaac atcactaaaa ataacgtctt tagcgtttgg      900

gaaaaaggca agcaatggga actcgacaat cggaccaacc taatgcagcc cggtcctgcg      960

gcagcgacca cctttagcgg agaacctgac cgtcaagcca tgcaaaacac gctggctttt     1020

agcaggaccg tctacgatca aacgaccgcc acgaccgatc gtaaccagat actcatcacc     1080

aacgaagacg aaatcagacc caccaactcg gtcggtatcg acgcgtgggg agcagttccc     1140

accaacaacc agtcgatcgt gacccccggc actcgcgcgg ccgtcaacaa tcaaggggcg     1200

cttcccggga tggtgtggca aaacagagac atttacccta cagggaccca tttggccaaa     1260

attcccgaca ctgacaatca cttccatccg tccccgctta ttgggcggtt tggctgcaag     1320

catccccctc cccagatttt cattaaaaac acacccgtcc ctgccaaccc ttcggaaacg     1380

ttccagacgg ccaaagtggc ctccttcatc aaccagtact cgaccggaca gtgcaccgtc     1440

gaaatctttt gggaactcaa gaaggaaacc tccaagcgct ggaaccccga aatccagttc     1500

acctccaact ttggcaacgc ggccgacatc cagtttgccg tctccgacac gggatcctat     1560

tccgaacctc gtcccatcgg tacccgttac cttaccaaac ctctgtaa                  1608


<210> 5182
<211> 2232
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5182
atgtctctca tttctgatgc gattccagat tggttggagc ggttggtcaa aaagggagtg       60

aatgctgcag ctgatttcta ccatttggaa agcggtcctc ctcgtcctaa ggcaaatcag      120

caaactcaag aatctcttga aaaggacgat tcgagaggtc tcgtgttccc aggctacaat      180

tatctaggcc ctttcaacgg tctagataaa ggagaacccg tcaacgaggc agacgctgcc      240

gccttagaac acgacaaggc ttacgacctc gaaatcaagg acgggcacaa cccgtacttt      300

gagtacaacg aggccgacag acgtttccag gaacgtctca aagacgatac ctcctttgga      360

ggcaatttag gtaaagccat cttccaggcc aaaaagaggg ttctcgaacc ctttggtctg      420

gtggaagact caaagacggc tccgaccgga gacaagcgga aaggcgaaga cgaacctcgt      480

ttgcccgaca cttcttcaca gactcccaag aaaaacaaga agcctcgcaa ggaaagacct      540

tccggcgggg cagaagatcc gggcgaaggc acctcttcca acgctggagc agcagcaccc      600

gcctctagtg tgggatcatc tatcatggct gaaggaggtg gcggcccagt gggcgatgca      660

ggccagggtg ccgatggagt gggcaattcc tccggaaatt ggcattgcga ttcccaatgg      720

ctggaaaacg gagtcgtcac tcgaaccacc cgaacctggg tcttgcccag ctacaacaac      780

cacctgtaca aacgaatcca aggacccagc ggaggcgaca acaacaacaa attctttgga      840

ttcagcaccc cctggggata ctttgactac aatcgattcc actgccactt ttccccgcga      900

gactggcaac gactcatcaa caacaactgg ggcatccgtc ccaaagcgat gcgctttaga      960

ctctttaaca tccaggttaa agaggtcacg gtccaagact tcaacaccac catcggcaac     1020

aacctcacca gtacggtcca ggtctttgcg gacaaggact accaactgcc gtacgtcctc     1080

ggatcggcta ccgaaggcac cttcccgccg ttcccagcgg atatctacac gatcccgcag     1140

tacgggtact gcacgctaaa ctacaacaac gaggcggtgg atcgttcggc cttctactgt     1200

ctggactact ttccctcaga catgctgcgg acaggaaata actttgagtt tacttacacc     1260

ttcgaggacg ttcctttcca tagcatgttt gcccacaacc agacgctaga ccggctgatg     1320

aatcccctcg tggatcagta cctctgggct ttcagctccg tcagccaagc aggctcatct     1380

ggacgagctc ttcattactc gcgggcgact aaaaccaaca tggcggctca atataggaac     1440

tggttacctg ggcctttctt ccgtgatcag caaatcttta cgggcgctag caacatcact     1500

aaaaataacg tctttagcgt ttgggaaaaa ggcaagcaat gggaactcga caatcggacc     1560

aacctaatgc agcccggtcc tgcggcagcg accaccttta gcggagaacc tgaccgtcaa     1620

gccatgcaaa acacgctggc ttttagcagg accgtctacg atcaaacgac cgccacgacc     1680

gatcgtaacc agatactcat caccaacgaa gacgaaatca gacccaccaa ctcggtcggt     1740

atcgacgcgt ggggagcagt tcccaccaac aaccagtcga tcgtgacccc cggcactcgc     1800

gcggccgtca acaatcaagg ggcgcttccc gggatggtgt ggcaaaacag agacatttac     1860

cctacaggga cccatttggc caaaattccc gacactgaca atcacttcca tccgtccccg     1920

cttattgggc ggtttggctg caagcatccc cctccccaga ttttcattaa aaacacaccc     1980

gtccctgcca acccttcgga aacgttccag acggccaaag tggcctcctt catcaaccag     2040

tactcgaccg gacagtgcac cgtcgaaatc ttttgggaac tcaagaagga aacctccaag     2100

cgctggaacc ccgaaatcca gttcacctcc aactttggca acgcggccga catccagttt     2160

gccgtctccg acacgggatc ctattccgaa cctcgtccca tcggtacccg ttaccttacc     2220

aaacctctgt aa                                                         2232


<210> 5183
<211> 535
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5183
Met Ala Glu Gly Gly Gly Gly Pro Val Gly Asp Ala Gly Gln Gly Ala 
1               5                   10                  15      


Asp Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp 
            20                  25                  30          


Leu Glu Asn Gly Val Val Thr Arg Thr Thr Arg Thr Trp Val Leu Pro 
        35                  40                  45              


Ser Tyr Asn Asn His Leu Tyr Lys Arg Ile Gln Gly Pro Ser Gly Gly 
    50                  55                  60                  


Asp Asn Asn Asn Lys Phe Phe Gly Phe Ser Thr Pro Trp Gly Tyr Phe 
65                  70                  75                  80  


Asp Tyr Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg 
                85                  90                  95      


Leu Ile Asn Asn Asn Trp Gly Ile Arg Pro Lys Ala Met Arg Phe Arg 
            100                 105                 110         


Leu Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Phe Asn Thr 
        115                 120                 125             


Thr Ile Gly Asn Asn Leu Thr Ser Thr Val Gln Val Phe Ala Asp Lys 
    130                 135                 140                 


Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala Thr Glu Gly Thr Phe 
145                 150                 155                 160 


Pro Pro Phe Pro Ala Asp Ile Tyr Thr Ile Pro Gln Tyr Gly Tyr Cys 
                165                 170                 175     


Thr Leu Asn Tyr Asn Asn Glu Ala Val Asp Arg Ser Ala Phe Tyr Cys 
            180                 185                 190         


Leu Asp Tyr Phe Pro Ser Asp Met Leu Arg Thr Gly Asn Asn Phe Glu 
        195                 200                 205             


Phe Thr Tyr Thr Phe Glu Asp Val Pro Phe His Ser Met Phe Ala His 
    210                 215                 220                 


Asn Gln Thr Leu Asp Arg Leu Met Asn Pro Leu Val Asp Gln Tyr Leu 
225                 230                 235                 240 


Trp Ala Phe Ser Ser Val Ser Gln Ala Gly Ser Ser Gly Arg Ala Leu 
                245                 250                 255     


His Tyr Ser Arg Ala Thr Lys Thr Asn Met Ala Ala Gln Tyr Arg Asn 
            260                 265                 270         


Trp Leu Pro Gly Pro Phe Phe Arg Asp Gln Gln Ile Phe Thr Gly Ala 
        275                 280                 285             


Ser Asn Ile Thr Lys Asn Asn Val Phe Ser Val Trp Glu Lys Gly Lys 
    290                 295                 300                 


Gln Trp Glu Leu Asp Asn Arg Thr Asn Leu Met Gln Pro Gly Pro Ala 
305                 310                 315                 320 


Ala Ala Thr Thr Phe Ser Gly Glu Pro Asp Arg Gln Ala Met Gln Asn 
                325                 330                 335     


Thr Leu Ala Phe Ser Arg Thr Val Tyr Asp Gln Thr Thr Ala Thr Thr 
            340                 345                 350         


Asp Arg Asn Gln Ile Leu Ile Thr Asn Glu Asp Glu Ile Arg Pro Thr 
        355                 360                 365             


Asn Ser Val Gly Ile Asp Ala Trp Gly Ala Val Pro Thr Asn Asn Gln 
    370                 375                 380                 


Ser Ile Val Thr Pro Gly Thr Arg Ala Ala Val Asn Asn Gln Gly Ala 
385                 390                 395                 400 


Leu Pro Gly Met Val Trp Gln Asn Arg Asp Ile Tyr Pro Thr Gly Thr 
                405                 410                 415     


His Leu Ala Lys Ile Pro Asp Thr Asp Asn His Phe His Pro Ser Pro 
            420                 425                 430         


Leu Ile Gly Arg Phe Gly Cys Lys His Pro Pro Pro Gln Ile Phe Ile 
        435                 440                 445             


Lys Asn Thr Pro Val Pro Ala Asn Pro Ser Glu Thr Phe Gln Thr Ala 
    450                 455                 460                 


Lys Val Ala Ser Phe Ile Asn Gln Tyr Ser Thr Gly Gln Cys Thr Val 
465                 470                 475                 480 


Glu Ile Phe Trp Glu Leu Lys Lys Glu Thr Ser Lys Arg Trp Asn Pro 
                485                 490                 495     


Glu Ile Gln Phe Thr Ser Asn Phe Gly Asn Ala Ala Asp Ile Gln Phe 
            500                 505                 510         


Ala Val Ser Asp Thr Gly Ser Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
        515                 520                 525             


Arg Tyr Leu Thr Lys Pro Leu 
    530                 535 


<210> 5184
<211> 440
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5184
Met Glu Leu Val Asp Trp Leu Val Glu Lys Gly Ile Thr Thr Glu Lys 
1               5                   10                  15      


Glu Trp Leu Leu Glu Asn Arg Glu Ser Phe Arg Ser Phe Gln Ala Ser 
            20                  25                  30          


Ser Asn Ser Ala Arg Gln Ile Lys Thr Ala Leu Gln Gly Ala Ile Gln 
        35                  40                  45              


Glu Met Leu Leu Thr Lys Thr Ala Glu Asp Tyr Leu Val Gly Lys Asp 
    50                  55                  60                  


Pro Val Ser Asp Asp Asp Ile Arg Gln Asn Arg Ile Tyr Lys Ile Leu 
65                  70                  75                  80  


Glu Leu Asn His Tyr Asp Pro Ala Tyr Val Gly Ser Ile Leu Val Gly 
                85                  90                  95      


Trp Cys Gln Lys Lys Trp Gly Lys Arg Asn Thr Leu Trp Leu Phe Gly 
            100                 105                 110         


His Ala Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala 
        115                 120                 125             


Val Pro Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe 
    130                 135                 140                 


Asn Asp Cys Val Glu Lys Met Ile Ile Trp Trp Glu Glu Gly Lys Met 
145                 150                 155                 160 


Thr Ala Lys Val Val Glu Thr Ala Lys Ala Ile Leu Gly Gly Ser Arg 
                165                 170                 175     


Val Arg Val Asp Gln Lys Cys Lys Ala Ser Val Pro Ile Glu Pro Thr 
            180                 185                 190         


Pro Val Ile Ile Thr Ser Asn Thr Asn Met Cys Tyr Val Ile Asp Gly 
        195                 200                 205             


Asn Thr Thr Thr Phe Glu His Lys Gln Pro Leu Glu Asp Arg Met Phe 
    210                 215                 220                 


Lys Leu Glu Leu Leu Thr Arg Leu Pro Asp Asp Phe Gly Lys Val Thr 
225                 230                 235                 240 


Lys Gln Glu Val Arg Gln Phe Phe Arg Trp Ser Gln Asp His Leu Thr 
                245                 250                 255     


Pro Val Ile Pro Glu Phe Leu Val Arg Lys Ala Glu Ser Arg Lys Arg 
            260                 265                 270         


Pro Ala Pro Ser Gly Glu Gly Tyr Ile Ser Pro Thr Lys Arg Pro Ala 
        275                 280                 285             


Leu Ala Glu Gln Gln Gln Ala Ser Glu Ser Ala Asp Pro Val Pro Thr 
    290                 295                 300                 


Arg Tyr Arg Ile Lys Cys Ser Lys His Cys Gly Met Asp Lys Met Leu 
305                 310                 315                 320 


Phe Pro Cys Gln Ile Cys Glu Ser Met Asn Arg Asp Ile Asn Ile Cys 
                325                 330                 335     


Ala Ile His Lys Thr Thr Asp Cys Lys Glu Cys Phe Pro Asp Tyr Gly 
            340                 345                 350         


Asp Lys Asp Asp Val Glu Leu Pro Pro Cys Thr Glu His Asn Val Ser 
        355                 360                 365             


Arg Cys Tyr Gln Cys His Ser Gly Glu Leu Tyr Arg Val Thr Ser Asp 
    370                 375                 380                 


Ser Asp Glu Lys Pro Ala Pro Glu Ser Asp Glu Gly Thr Glu Pro Ser 
385                 390                 395                 400 


Tyr Ala Pro Cys Thr Ile His His Leu Met Gly Lys Ser His Gly Leu 
                405                 410                 415     


Val Thr Cys Ala Ala Cys Arg Leu Lys Asn Ser Thr Leu His Asp Asp 
            420                 425                 430         


Leu Asp Asp Gly Asp Leu Glu Gln 
        435                 440 


<210> 5185
<211> 319
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5185
Met Glu Leu Val Asp Trp Leu Val Glu Lys Gly Ile Thr Thr Glu Lys 
1               5                   10                  15      


Glu Trp Leu Leu Glu Asn Arg Glu Ser Phe Arg Ser Phe Gln Ala Ser 
            20                  25                  30          


Ser Asn Ser Ala Arg Gln Ile Lys Thr Ala Leu Gln Gly Ala Ile Gln 
        35                  40                  45              


Glu Met Leu Leu Thr Lys Thr Ala Glu Asp Tyr Leu Val Gly Lys Asp 
    50                  55                  60                  


Pro Val Ser Asp Asp Asp Ile Arg Gln Asn Arg Ile Tyr Lys Ile Leu 
65                  70                  75                  80  


Glu Leu Asn His Tyr Asp Pro Ala Tyr Val Gly Ser Ile Leu Val Gly 
                85                  90                  95      


Trp Cys Gln Lys Lys Trp Gly Lys Arg Asn Thr Leu Trp Leu Phe Gly 
            100                 105                 110         


His Ala Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala 
        115                 120                 125             


Val Pro Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe 
    130                 135                 140                 


Asn Asp Cys Val Glu Lys Met Ile Ile Trp Trp Glu Glu Gly Lys Met 
145                 150                 155                 160 


Thr Ala Lys Val Val Glu Thr Ala Lys Ala Ile Leu Gly Gly Ser Arg 
                165                 170                 175     


Val Arg Val Asp Gln Lys Cys Lys Ala Ser Val Pro Ile Glu Pro Thr 
            180                 185                 190         


Pro Val Ile Ile Thr Ser Asn Thr Asn Met Cys Tyr Val Ile Asp Gly 
        195                 200                 205             


Asn Thr Thr Thr Phe Glu His Lys Gln Pro Leu Glu Asp Arg Met Phe 
    210                 215                 220                 


Lys Leu Glu Leu Leu Thr Arg Leu Pro Asp Asp Phe Gly Lys Val Thr 
225                 230                 235                 240 


Lys Gln Glu Val Arg Gln Phe Phe Arg Trp Ser Gln Asp His Leu Thr 
                245                 250                 255     


Pro Val Ile Pro Glu Phe Leu Val Arg Lys Ala Glu Ser Arg Lys Arg 
            260                 265                 270         


Pro Ala Pro Ser Gly Glu Gly Tyr Ile Ser Pro Thr Lys Arg Pro Ala 
        275                 280                 285             


Leu Ala Glu Gln Gln Gln Ala Ser Glu Ser Ala Asp Pro Val Pro Thr 
    290                 295                 300                 


Arg Leu Val Gly Ala Val Gly Gln Lys Gly Ser Glu Cys Cys Ser 
305                 310                 315                 


<210> 5186
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5186
Met Arg Ser Tyr Tyr Glu Val Ile Val Gln Leu Pro Asn Asp Val Glu 
1               5                   10                  15      


Ser Gln Val Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Ile Thr Ser 
            20                  25                  30          


Arg Glu Trp Thr Leu Pro Glu Asp Ala Asp Trp Asp Leu Asp Gln Val 
        35                  40                  45              


Asp Gln Val Gln Leu Thr Leu Gly Asp Lys Ile Gln Arg Glu Ile Arg 
    50                  55                  60                  


Thr His Trp Gly Thr Met Ala Lys Glu Pro Asp Phe His Tyr Phe Ile 
65                  70                  75                  80  


Gln Leu Glu Gln Gly Glu Val Phe Phe His Leu His Val Leu Leu Glu 
                85                  90                  95      


Thr Cys Ser Val Lys Pro Met Val Leu Gly Arg Tyr Ile Arg His Ile 
            100                 105                 110         


Gln Gln Lys Ile Val Ser Lys Val Tyr Cys Ala Thr Ser Leu Arg Trp 
        115                 120                 125             


Lys Asp Gly Cys Val Val Thr Lys Thr Lys Asn Phe Gly Gly Ala Asn 
    130                 135                 140                 


Lys Val Arg Ala Glu Ser Tyr Ile Pro Ala Tyr Leu Ile Pro Lys Gln 
145                 150                 155                 160 


Gln Pro Glu Val Gln Trp Ala Trp Thr Asn Val Pro Glu Tyr Ile Lys 
                165                 170                 175     


Ala Cys Leu His Arg Glu Leu Arg Ala Ser Leu Ala Arg Leu His Phe 
            180                 185                 190         


Glu Glu Ala Gly Val Ser Gln Ser Lys Glu Asn Leu Ala Arg Thr Ala 
        195                 200                 205             


Asp Gly Ala Pro Val Met Pro Thr Arg Val Ser Lys Arg Tyr Met Glu 
    210                 215                 220                 


Leu Val Asp Trp Leu Val Glu Lys Gly Ile Thr Thr Glu Lys Glu Trp 
225                 230                 235                 240 


Leu Leu Glu Asn Arg Glu Ser Phe Arg Ser Phe Gln Ala Ser Ser Asn 
                245                 250                 255     


Ser Ala Arg Gln Ile Lys Thr Ala Leu Gln Gly Ala Ile Gln Glu Met 
            260                 265                 270         


Leu Leu Thr Lys Thr Ala Glu Asp Tyr Leu Val Gly Lys Asp Pro Val 
        275                 280                 285             


Ser Asp Asp Asp Ile Arg Gln Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn His Tyr Asp Pro Ala Tyr Val Gly Ser Ile Leu Val Gly Trp Cys 
305                 310                 315                 320 


Gln Lys Lys Trp Gly Lys Arg Asn Thr Leu Trp Leu Phe Gly His Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Glu Lys Met Ile Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Thr Ala Lys Ala Ile Leu Gly Gly Ser Arg Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ala Ser Val Pro Ile Glu Pro Thr Pro Val 
                405                 410                 415     


Ile Ile Thr Ser Asn Thr Asn Met Cys Tyr Val Ile Asp Gly Asn Thr 
            420                 425                 430         


Thr Thr Phe Glu His Lys Gln Pro Leu Glu Asp Arg Met Phe Lys Leu 
        435                 440                 445             


Glu Leu Leu Thr Arg Leu Pro Asp Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Arg Gln Phe Phe Arg Trp Ser Gln Asp His Leu Thr Pro Val 
465                 470                 475                 480 


Ile Pro Glu Phe Leu Val Arg Lys Ala Glu Ser Arg Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Gly Glu Gly Tyr Ile Ser Pro Thr Lys Arg Pro Ala Leu Ala 
            500                 505                 510         


Glu Gln Gln Gln Ala Ser Glu Ser Ala Asp Pro Val Pro Thr Arg Tyr 
        515                 520                 525             


Arg Ile Lys Cys Ser Lys His Cys Gly Met Asp Lys Met Leu Phe Pro 
    530                 535                 540                 


Cys Gln Ile Cys Glu Ser Met Asn Arg Asp Ile Asn Ile Cys Ala Ile 
545                 550                 555                 560 


His Lys Thr Thr Asp Cys Lys Glu Cys Phe Pro Asp Tyr Gly Asp Lys 
                565                 570                 575     


Asp Asp Val Glu Leu Pro Pro Cys Thr Glu His Asn Val Ser Arg Cys 
            580                 585                 590         


Tyr Gln Cys His Ser Gly Glu Leu Tyr Arg Val Thr Ser Asp Ser Asp 
        595                 600                 605             


Glu Lys Pro Ala Pro Glu Ser Asp Glu Gly Thr Glu Pro Ser Tyr Ala 
    610                 615                 620                 


Pro Cys Thr Ile His His Leu Met Gly Lys Ser His Gly Leu Val Thr 
625                 630                 635                 640 


Cys Ala Ala Cys Arg Leu Lys Asn Ser Thr Leu His Asp Asp Leu Asp 
                645                 650                 655     


Asp Gly Asp Leu Glu Gln 
            660         


<210> 5187
<211> 541
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5187
Met Arg Ser Tyr Tyr Glu Val Ile Val Gln Leu Pro Asn Asp Val Glu 
1               5                   10                  15      


Ser Gln Val Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Ile Thr Ser 
            20                  25                  30          


Arg Glu Trp Thr Leu Pro Glu Asp Ala Asp Trp Asp Leu Asp Gln Val 
        35                  40                  45              


Asp Gln Val Gln Leu Thr Leu Gly Asp Lys Ile Gln Arg Glu Ile Arg 
    50                  55                  60                  


Thr His Trp Gly Thr Met Ala Lys Glu Pro Asp Phe His Tyr Phe Ile 
65                  70                  75                  80  


Gln Leu Glu Gln Gly Glu Val Phe Phe His Leu His Val Leu Leu Glu 
                85                  90                  95      


Thr Cys Ser Val Lys Pro Met Val Leu Gly Arg Tyr Ile Arg His Ile 
            100                 105                 110         


Gln Gln Lys Ile Val Ser Lys Val Tyr Cys Ala Thr Ser Leu Arg Trp 
        115                 120                 125             


Lys Asp Gly Cys Val Val Thr Lys Thr Lys Asn Phe Gly Gly Ala Asn 
    130                 135                 140                 


Lys Val Arg Ala Glu Ser Tyr Ile Pro Ala Tyr Leu Ile Pro Lys Gln 
145                 150                 155                 160 


Gln Pro Glu Val Gln Trp Ala Trp Thr Asn Val Pro Glu Tyr Ile Lys 
                165                 170                 175     


Ala Cys Leu His Arg Glu Leu Arg Ala Ser Leu Ala Arg Leu His Phe 
            180                 185                 190         


Glu Glu Ala Gly Val Ser Gln Ser Lys Glu Asn Leu Ala Arg Thr Ala 
        195                 200                 205             


Asp Gly Ala Pro Val Met Pro Thr Arg Val Ser Lys Arg Tyr Met Glu 
    210                 215                 220                 


Leu Val Asp Trp Leu Val Glu Lys Gly Ile Thr Thr Glu Lys Glu Trp 
225                 230                 235                 240 


Leu Leu Glu Asn Arg Glu Ser Phe Arg Ser Phe Gln Ala Ser Ser Asn 
                245                 250                 255     


Ser Ala Arg Gln Ile Lys Thr Ala Leu Gln Gly Ala Ile Gln Glu Met 
            260                 265                 270         


Leu Leu Thr Lys Thr Ala Glu Asp Tyr Leu Val Gly Lys Asp Pro Val 
        275                 280                 285             


Ser Asp Asp Asp Ile Arg Gln Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn His Tyr Asp Pro Ala Tyr Val Gly Ser Ile Leu Val Gly Trp Cys 
305                 310                 315                 320 


Gln Lys Lys Trp Gly Lys Arg Asn Thr Leu Trp Leu Phe Gly His Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Glu Lys Met Ile Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Thr Ala Lys Ala Ile Leu Gly Gly Ser Arg Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ala Ser Val Pro Ile Glu Pro Thr Pro Val 
                405                 410                 415     


Ile Ile Thr Ser Asn Thr Asn Met Cys Tyr Val Ile Asp Gly Asn Thr 
            420                 425                 430         


Thr Thr Phe Glu His Lys Gln Pro Leu Glu Asp Arg Met Phe Lys Leu 
        435                 440                 445             


Glu Leu Leu Thr Arg Leu Pro Asp Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Arg Gln Phe Phe Arg Trp Ser Gln Asp His Leu Thr Pro Val 
465                 470                 475                 480 


Ile Pro Glu Phe Leu Val Arg Lys Ala Glu Ser Arg Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Gly Glu Gly Tyr Ile Ser Pro Thr Lys Arg Pro Ala Leu Ala 
            500                 505                 510         


Glu Gln Gln Gln Ala Ser Glu Ser Ala Asp Pro Val Pro Thr Arg Leu 
        515                 520                 525             


Val Gly Ala Val Gly Gln Lys Gly Ser Glu Cys Cys Ser 
    530                 535                 540     


<210> 5188
<211> 743
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5188
Met Ser Leu Ile Ser Asp Ala Ile Pro Asp Trp Leu Glu Arg Leu Val 
1               5                   10                  15      


Lys Lys Gly Val Asn Ala Ala Ala Asp Phe Tyr His Leu Glu Ser Gly 
            20                  25                  30          


Pro Pro Arg Pro Lys Ala Asn Gln Gln Thr Gln Glu Ser Leu Glu Lys 
        35                  40                  45              


Asp Asp Ser Arg Gly Leu Val Phe Pro Gly Tyr Asn Tyr Leu Gly Pro 
    50                  55                  60                  


Phe Asn Gly Leu Asp Lys Gly Glu Pro Val Asn Glu Ala Asp Ala Ala 
65                  70                  75                  80  


Ala Leu Glu His Asp Lys Ala Tyr Asp Leu Glu Ile Lys Asp Gly His 
                85                  90                  95      


Asn Pro Tyr Phe Glu Tyr Asn Glu Ala Asp Arg Arg Phe Gln Glu Arg 
            100                 105                 110         


Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn Leu Gly Lys Ala Ile Phe 
        115                 120                 125             


Gln Ala Lys Lys Arg Val Leu Glu Pro Phe Gly Leu Val Glu Asp Ser 
    130                 135                 140                 


Lys Thr Ala Pro Thr Gly Asp Lys Arg Lys Gly Glu Asp Glu Pro Arg 
145                 150                 155                 160 


Leu Pro Asp Thr Ser Ser Gln Thr Pro Lys Lys Asn Lys Lys Pro Arg 
                165                 170                 175     


Lys Glu Arg Pro Ser Gly Gly Ala Glu Asp Pro Gly Glu Gly Thr Ser 
            180                 185                 190         


Ser Asn Ala Gly Ala Ala Ala Pro Ala Ser Ser Val Gly Ser Ser Ile 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gly Pro Val Gly Asp Ala Gly Gln Gly Ala 
    210                 215                 220                 


Asp Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp 
225                 230                 235                 240 


Leu Glu Asn Gly Val Val Thr Arg Thr Thr Arg Thr Trp Val Leu Pro 
                245                 250                 255     


Ser Tyr Asn Asn His Leu Tyr Lys Arg Ile Gln Gly Pro Ser Gly Gly 
            260                 265                 270         


Asp Asn Asn Asn Lys Phe Phe Gly Phe Ser Thr Pro Trp Gly Tyr Phe 
        275                 280                 285             


Asp Tyr Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg 
    290                 295                 300                 


Leu Ile Asn Asn Asn Trp Gly Ile Arg Pro Lys Ala Met Arg Phe Arg 
305                 310                 315                 320 


Leu Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Phe Asn Thr 
                325                 330                 335     


Thr Ile Gly Asn Asn Leu Thr Ser Thr Val Gln Val Phe Ala Asp Lys 
            340                 345                 350         


Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala Thr Glu Gly Thr Phe 
        355                 360                 365             


Pro Pro Phe Pro Ala Asp Ile Tyr Thr Ile Pro Gln Tyr Gly Tyr Cys 
    370                 375                 380                 


Thr Leu Asn Tyr Asn Asn Glu Ala Val Asp Arg Ser Ala Phe Tyr Cys 
385                 390                 395                 400 


Leu Asp Tyr Phe Pro Ser Asp Met Leu Arg Thr Gly Asn Asn Phe Glu 
                405                 410                 415     


Phe Thr Tyr Thr Phe Glu Asp Val Pro Phe His Ser Met Phe Ala His 
            420                 425                 430         


Asn Gln Thr Leu Asp Arg Leu Met Asn Pro Leu Val Asp Gln Tyr Leu 
        435                 440                 445             


Trp Ala Phe Ser Ser Val Ser Gln Ala Gly Ser Ser Gly Arg Ala Leu 
    450                 455                 460                 


His Tyr Ser Arg Ala Thr Lys Thr Asn Met Ala Ala Gln Tyr Arg Asn 
465                 470                 475                 480 


Trp Leu Pro Gly Pro Phe Phe Arg Asp Gln Gln Ile Phe Thr Gly Ala 
                485                 490                 495     


Ser Asn Ile Thr Lys Asn Asn Val Phe Ser Val Trp Glu Lys Gly Lys 
            500                 505                 510         


Gln Trp Glu Leu Asp Asn Arg Thr Asn Leu Met Gln Pro Gly Pro Ala 
        515                 520                 525             


Ala Ala Thr Thr Phe Ser Gly Glu Pro Asp Arg Gln Ala Met Gln Asn 
    530                 535                 540                 


Thr Leu Ala Phe Ser Arg Thr Val Tyr Asp Gln Thr Thr Ala Thr Thr 
545                 550                 555                 560 


Asp Arg Asn Gln Ile Leu Ile Thr Asn Glu Asp Glu Ile Arg Pro Thr 
                565                 570                 575     


Asn Ser Val Gly Ile Asp Ala Trp Gly Ala Val Pro Thr Asn Asn Gln 
            580                 585                 590         


Ser Ile Val Thr Pro Gly Thr Arg Ala Ala Val Asn Asn Gln Gly Ala 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asn Arg Asp Ile Tyr Pro Thr Gly Thr 
    610                 615                 620                 


His Leu Ala Lys Ile Pro Asp Thr Asp Asn His Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Ile Gly Arg Phe Gly Cys Lys His Pro Pro Pro Gln Ile Phe Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asn Pro Ser Glu Thr Phe Gln Thr Ala 
            660                 665                 670         


Lys Val Ala Ser Phe Ile Asn Gln Tyr Ser Thr Gly Gln Cys Thr Val 
        675                 680                 685             


Glu Ile Phe Trp Glu Leu Lys Lys Glu Thr Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Phe Thr Ser Asn Phe Gly Asn Ala Ala Asp Ile Gln Phe 
705                 710                 715                 720 


Ala Val Ser Asp Thr Gly Ser Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Lys Pro Leu 
            740             


<210> 5189
<211> 598
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5189
Thr Ala Pro Thr Gly Asp Lys Arg Lys Gly Glu Asp Glu Pro Arg Leu 
1               5                   10                  15      


Pro Asp Thr Ser Ser Gln Thr Pro Lys Lys Asn Lys Lys Pro Arg Lys 
            20                  25                  30          


Glu Arg Pro Ser Gly Gly Ala Glu Asp Pro Gly Glu Gly Thr Ser Ser 
        35                  40                  45              


Asn Ala Gly Ala Ala Ala Pro Ala Ser Ser Val Gly Ser Ser Ile Met 
    50                  55                  60                  


Ala Glu Gly Gly Gly Gly Pro Val Gly Asp Ala Gly Gln Gly Ala Asp 
65                  70                  75                  80  


Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu 
                85                  90                  95      


Glu Asn Gly Val Val Thr Arg Thr Thr Arg Thr Trp Val Leu Pro Ser 
            100                 105                 110         


Tyr Asn Asn His Leu Tyr Lys Arg Ile Gln Gly Pro Ser Gly Gly Asp 
        115                 120                 125             


Asn Asn Asn Lys Phe Phe Gly Phe Ser Thr Pro Trp Gly Tyr Phe Asp 
    130                 135                 140                 


Tyr Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu 
145                 150                 155                 160 


Ile Asn Asn Asn Trp Gly Ile Arg Pro Lys Ala Met Arg Phe Arg Leu 
                165                 170                 175     


Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Phe Asn Thr Thr 
            180                 185                 190         


Ile Gly Asn Asn Leu Thr Ser Thr Val Gln Val Phe Ala Asp Lys Asp 
        195                 200                 205             


Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala Thr Glu Gly Thr Phe Pro 
    210                 215                 220                 


Pro Phe Pro Ala Asp Ile Tyr Thr Ile Pro Gln Tyr Gly Tyr Cys Thr 
225                 230                 235                 240 


Leu Asn Tyr Asn Asn Glu Ala Val Asp Arg Ser Ala Phe Tyr Cys Leu 
                245                 250                 255     


Asp Tyr Phe Pro Ser Asp Met Leu Arg Thr Gly Asn Asn Phe Glu Phe 
            260                 265                 270         


Thr Tyr Thr Phe Glu Asp Val Pro Phe His Ser Met Phe Ala His Asn 
        275                 280                 285             


Gln Thr Leu Asp Arg Leu Met Asn Pro Leu Val Asp Gln Tyr Leu Trp 
    290                 295                 300                 


Ala Phe Ser Ser Val Ser Gln Ala Gly Ser Ser Gly Arg Ala Leu His 
305                 310                 315                 320 


Tyr Ser Arg Ala Thr Lys Thr Asn Met Ala Ala Gln Tyr Arg Asn Trp 
                325                 330                 335     


Leu Pro Gly Pro Phe Phe Arg Asp Gln Gln Ile Phe Thr Gly Ala Ser 
            340                 345                 350         


Asn Ile Thr Lys Asn Asn Val Phe Ser Val Trp Glu Lys Gly Lys Gln 
        355                 360                 365             


Trp Glu Leu Asp Asn Arg Thr Asn Leu Met Gln Pro Gly Pro Ala Ala 
    370                 375                 380                 


Ala Thr Thr Phe Ser Gly Glu Pro Asp Arg Gln Ala Met Gln Asn Thr 
385                 390                 395                 400 


Leu Ala Phe Ser Arg Thr Val Tyr Asp Gln Thr Thr Ala Thr Thr Asp 
                405                 410                 415     


Arg Asn Gln Ile Leu Ile Thr Asn Glu Asp Glu Ile Arg Pro Thr Asn 
            420                 425                 430         


Ser Val Gly Ile Asp Ala Trp Gly Ala Val Pro Thr Asn Asn Gln Ser 
        435                 440                 445             


Ile Val Thr Pro Gly Thr Arg Ala Ala Val Asn Asn Gln Gly Ala Leu 
    450                 455                 460                 


Pro Gly Met Val Trp Gln Asn Arg Asp Ile Tyr Pro Thr Gly Thr His 
465                 470                 475                 480 


Leu Ala Lys Ile Pro Asp Thr Asp Asn His Phe His Pro Ser Pro Leu 
                485                 490                 495     


Ile Gly Arg Phe Gly Cys Lys His Pro Pro Pro Gln Ile Phe Ile Lys 
            500                 505                 510         


Asn Thr Pro Val Pro Ala Asn Pro Ser Glu Thr Phe Gln Thr Ala Lys 
        515                 520                 525             


Val Ala Ser Phe Ile Asn Gln Tyr Ser Thr Gly Gln Cys Thr Val Glu 
    530                 535                 540                 


Ile Phe Trp Glu Leu Lys Lys Glu Thr Ser Lys Arg Trp Asn Pro Glu 
545                 550                 555                 560 


Ile Gln Phe Thr Ser Asn Phe Gly Asn Ala Ala Asp Ile Gln Phe Ala 
                565                 570                 575     


Val Ser Asp Thr Gly Ser Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg 
            580                 585                 590         


Tyr Leu Thr Lys Pro Leu 
        595             


<210> 5190
<211> 4694
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5190
tggccagttt ccaagacagg ctcgctcgct cactcgggcc ggggccccaa aggggcccct       60

agcgaccgct tcgcggtcgc ggcccgagtg agcgagcgag cctgtcttgg aaactggcca      120

gcactccggt gaggtaatgc cgtcacgtgg tcgggaatgg gaacgggaaa tctcgcgaga      180

acgtaaacaa atataagacg gcgccacacg gcgctgcgtc atacgcgcgc gcgcaccggc      240

gagatgaggt cgtactacga ggtcatcgtt cagctgccca acgacgtcga gagtcaggta      300

cctggaatct ccgattcgtt cgtcaactgg attacgtcgc gagaatggac gttgcctgag      360

gacgccgatt gggatttgga ccaggtcgat caagttcaac tgacgctcgg cgacaaaatc      420

caacgggaga ttcgaactca ttgggggacg atggccaaag aaccggactt tcactatttt      480

atccaactgg aacaaggtga ggtgttcttt catttacacg tcctgctgga aacgtgttcc      540

gtaaagccga tggtactcgg aagatatatc cgacatattc aacaaaaaat tgtgagtaaa      600

gtctactgcg ccacgagcct acgatggaag gatggatgcg tggtgaccaa gaccaaaaat      660

ttcgggggcg cgaacaaggt ccgggccgag tcgtatattc ccgcctacct gatcccgaaa      720

cagcaaccgg aagtgcagtg ggcgtggact aacgtgcccg agtatataaa agcgtgcttg      780

caccgagaac tgcgtgccag tctcgcgcga cttcacttcg aggaggcggg cgtctcgcaa      840

tccaaggaaa atctcgcgag aactgcagac ggcgctcccg tgatgccgac ccgcgtcagc      900

aaacgctaca tggagctcgt ggattggctc gtggagaagg ggatcaccac cgagaaggaa      960

tggctgctgg aaaacagaga aagctttcgg agctttcagg cctcgagcaa ctcggcgcgt     1020

cagatcaaga cggccctgca aggcgccatt caggagatgc ttctgaccaa gacggcggag     1080

gactacctcg tcggaaagga tcccgtctcg gacgacgaca tccgtcagaa ccgcatctac     1140

aagattctgg aactgaacca ctacgaccca gcgtacgtgg ggagtatttt ggtcgggtgg     1200

tgccagaaga aatggggcaa gcgaaacacg ctgtggctgt tcggacatgc gaccaccggc     1260

aagaccaaca tcgcggaggc tattgcccat gctgtgccgt tctatggatg cgttaactgg     1320

accaacgaga actttccgtt caacgactgc gtcgaaaaaa tgattatctg gtgggaggag     1380

ggcaaaatga ccgccaaagt ggtggaaaca gccaaggcga ttctgggagg atctcgggtg     1440

agagtggacc aaaaatgcaa agcttcggtt ccgatcgaac cgacgccggt cattattacc     1500

agtaacacca acatgtgtta tgtcatcgac gggaacacga ccacgttcga gcataagcag     1560

ccgttggagg acaggatgtt taagctcgaa ttgctgactc ggttgcctga tgactttggt     1620

aaggtgacca aacaggaggt gcgtcaattc ttcaggtggt ctcaggatca cctgacccct     1680

gtgatcccag aattcctagt gcggaaggcg gagtctcgca aaagacccgc cccttccggg     1740

gaaggctata taagcccgac aaagcggccc gcgctcgcag agcagcagca ggcgtcggag     1800

agcgcggacc cggttcccac caggtatcgt atcaaatgct cgaaacattg cggtatggat     1860

aaaatgttgt ttccttgcca aatttgtgaa tcgatgaaca gagatattaa tatttgtgct     1920

attcataaaa cgaccgactg taaagagtgt ttccccgact acggggataa agatgatgta     1980

gaactacccc cctgtacaga acacaacgtg tctcgttgtt atcaatgtca ttcgggcgaa     2040

ttgtatcgcg tgacttcgga ctctgacgag aaacctgccc ccgagagtga tgaaggcacc     2100

gagccatcct atgctccctg cacgattcac cacctgatgg gcaagagtca cgggttagtc     2160

acttgcgcgg cgtgtcggtt gaaaaatagt acgttgcatg atgacttgga tgacggtgat     2220

ctcgaacaat aaatgattga aatgtagcca tgtctctcat ttctgatgcg attccagatt     2280

ggttggagcg gttggtcaaa aagggagtga atgctgcagc tgatttctac catttggaaa     2340

gcggtcctcc tcgtcctaag gcaaatcagc aaactcaaga atctcttgaa aaggacgatt     2400

cgagaggtct cgtgttccca ggctacaatt atctaggccc tttcaacggt ctagataaag     2460

gagaacccgt caacgaggca gacgctgccg ccttagaaca cgacaaggct tacgacctcg     2520

aaatcaagga cgggcacaac ccgtactttg agtacaacga ggccgacaga cgtttccagg     2580

aacgtctcaa agacgatacc tcctttggag gcaatttagg taaagccatc ttccaggcca     2640

aaaagagggt tctcgaaccc tttggtctgg tggaagactc aaagacggct ccgaccggag     2700

acaagcggaa aggcgaagac gaacctcgtt tgcccgacac ttcttcacag actcccaaga     2760

aaaacaagaa gcctcgcaag gaaagacctt ccggcggggc agaagatccg ggcgaaggca     2820

cctcttccaa cgctggagca gcagcacccg cctctagtgt gggatcatct atcatggctg     2880

aaggaggtgg cggcccagtg ggcgatgcag gccagggtgc cgatggagtg ggcaattcct     2940

ccggaaattg gcattgcgat tcccaatggc tggaaaacgg agtcgtcact cgaaccaccc     3000

gaacctgggt cttgcccagc tacaacaacc acctgtacaa acgaatccaa ggacccagcg     3060

gaggcgacaa caacaacaaa ttctttggat tcagcacccc ctggggatac tttgactaca     3120

atcgattcca ctgccacttt tccccgcgag actggcaacg actcatcaac aacaactggg     3180

gcatccgtcc caaagcgatg cgctttagac tctttaacat ccaggttaaa gaggtcacgg     3240

tccaagactt caacaccacc atcggcaaca acctcaccag tacggtccag gtctttgcgg     3300

acaaggacta ccaactgccg tacgtcctcg gatcggctac cgaaggcacc ttcccgccgt     3360

tcccagcgga tatctacacg atcccgcagt acgggtactg cacgctaaac tacaacaacg     3420

aggcggtgga tcgttcggcc ttctactgtc tggactactt tccctcagac atgctgcgga     3480

caggaaataa ctttgagttt acttacacct tcgaggacgt tcctttccat agcatgtttg     3540

cccacaacca gacgctagac cggctgatga atcccctcgt ggatcagtac ctctgggctt     3600

tcagctccgt cagccaagca ggctcatctg gacgagctct tcattactcg cgggcgacta     3660

aaaccaacat ggcggctcaa tataggaact ggttacctgg gcctttcttc cgtgatcagc     3720

aaatctttac gggcgctagc aacatcacta aaaataacgt ctttagcgtt tgggaaaaag     3780

gcaagcaatg ggaactcgac aatcggacca acctaatgca gcccggtcct gcggcagcga     3840

ccacctttag cggagaacct gaccgtcaag ccatgcaaaa cacgctggct tttagcagga     3900

ccgtctacga tcaaacgacc gccacgaccg atcgtaacca gatactcatc accaacgaag     3960

acgaaatcag acccaccaac tcggtcggta tcgacgcgtg gggagcagtt cccaccaaca     4020

accagtcgat cgtgaccccc ggcactcgcg cggccgtcaa caatcaaggg gcgcttcccg     4080

ggatggtgtg gcaaaacaga gacatttacc ctacagggac ccatttggcc aaaattcccg     4140

acactgacaa tcacttccat ccgtccccgc ttattgggcg gtttggctgc aagcatcccc     4200

ctccccagat tttcattaaa aacacacccg tccctgccaa cccttcggaa acgttccaga     4260

cggccaaagt ggcctccttc atcaaccagt actcgaccgg acagtgcacc gtcgaaatct     4320

tttgggaact caagaaggaa acctccaagc gctggaaccc cgaaatccag ttcacctcca     4380

actttggcaa cgcggccgac atccagtttg ccgtctccga cacgggatcc tattccgaac     4440

ctcgtcccat cggtacccgt taccttacca aacctctgta aattaaaccc ttcaataaac     4500

cgtttatgcg taactgtatt tccgtctcct gtcgttattc agtcacatga tgcggcatta     4560

cctcaccgga gtgctggcca gtttccaaga caggctcgct cgctcactcg ggccggggcc     4620

ccaaaggggc ccctagcgac cgcttcgcgg tcgcggcccg agtgagcgag cgagcctgtc     4680

ttggaaactg gcca                                                       4694


<210> 5191
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5191
atggctgctg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggtga caacccctac ctcaagtaca accacgccga cgcggagttc      300

cagcagcggc ttcagggcga cacatcgttt gggggcaacc tcggcagagc agtcttccag      360

gccaaaaaga gggttcttga acctcttggt ctggttgagc aagcgggtga gacggctcct      420

ggaaagaaga gaccgttgat tgaatccccc cagcagcccg actcctccac gggtatcggc      480

aaaaaaggca agcagccggc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggtgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg acttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc agactatcag ctcccgtacg tgctcgggtc ggctcacgag     1080

ggctgcctcc cgccgttccc agcagacgtc ttcatggtgc cacagtatgg atacctcacc     1140

ctgaacaacg ggagtcaggc agtaggacgc tcttcatttt actgcctgga gtactttcct     1200

tctcagatgc tgcgtaccgg aaacaacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagt ctggaccgtc tcatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5192
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5192
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Gln Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Gln Ala Gly Glu Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Leu Ile Glu Ser Pro Gln Gln Pro Asp Ser Ser Thr Gly Ile Gly 
145                 150                 155                 160 


Lys Lys Gly Lys Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Asp Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5193
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5193
atggcttccg atggttatct tccagattgg ctcgaggaca acctctctga gggcatccgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca gagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt accttcagct acaccttcga ggacgtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt accggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attctactgg ccaagtcagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgtcccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5194
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5194
Met Ala Ser Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Arg Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5195
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5195
atggctgctg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggtga caacccctac ctcaagtaca accacgccga cgcggagttc      300

cagcagcggc ttcagggcga cacatcgttt gggggcaacc tcggcagagc agtcttccag      360

gccaaaaaga gggttcttga acctcttggt ctggttgagc aagcgggtga gacggctcct      420

ggaaagaaga gaccgttgat tgaatccccc cagcagcccg actcctccac gggtatcggc      480

aaaaaaggca agcagccggc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggtgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg acttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc agactatcag ctcccgtacg tgctcgggtc ggctcacgag     1080

ggctgcctcc cgccgttccc agcagacgtc ttcatggtgc cacagtatgg atacctcacc     1140

ctgaacaacg ggagtcaggc agtaggacgc tcttcatttt actgcctgga gtactttcct     1200

tctcagatgc tgcgtaccgg aaacaacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagt ctggaccgtc tcatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccaactggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ctgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgccatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5196
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5196
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Gln Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Gln Ala Gly Glu Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Leu Ile Glu Ser Pro Gln Gln Pro Asp Ser Ser Thr Gly Ile Gly 
145                 150                 155                 160 


Lys Lys Gly Lys Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Asp Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Thr Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5197
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5197
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcaatcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt cgacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg actttaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca actggggatt ccggcccaag agactcagct tcaagctctt caacatccag      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgat     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca taaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac attgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtccccagta a              2211


<210> 5198
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5198
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Ile Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Gln 
                725                 730                 735     


<210> 5199
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5199
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac cttcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga gggttctcga acctctcggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg acttcaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt accggcagca gtgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5200
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5200
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Cys Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5201
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5201
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gaatggtggg acttgaaacc tggagccccg aaacccaaag tcaaccagca aaagcaggac      120

aacgctcggg gtcttgtgct tccgggttac aaatacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac cttcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggacgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg acttcaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccaactggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ctgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgccatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5202
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5202
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Val Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Thr Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5203
<211> 2208
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (955)..(955)
<223> a, c, t or g

<220>
<221> modified_base
<222> (971)..(972)
<223> a, c, t or g

<220>
<221> modified_base
<222> (981)..(981)
<223> a, c, t or g

<220>
<221> modified_base
<222> (986)..(986)
<223> a, c, t or g

<220>
<221> modified_base
<222> (1235)..(1235)
<223> a, c, t or g

<220>
<221> modified_base
<222> (1694)..(1696)
<223> a, c, t or g

<220>
<221> modified_base
<222> (1698)..(1698)
<223> a, c, t or g

<220>
<221> modified_base
<222> (1763)..(1765)
<223> a, c, t or g

<220>
<221> modified_base
<222> (1778)..(1778)
<223> a, c, t or g

<220>
<221> modified_base
<222> (2204)..(2204)
<223> a, c, t or g

<400> 5203
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gaatggtggg acttgaaacc tggagccccg aaacccaaag tcaaccagca aaagcaggac      120

aacgctcggg gtcttgtgct tccgggttac aaatacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac cttcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggacgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaataaca attggggatt ccggcccaag agactcaact tcaaactctt caacntccaa      960

gtcaaggagg nnacgacgaa ngatgncgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt acctncagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccaactggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag agannncnaa gccactaacc ccgtggccac tgaaagattt gggactgtgg     1740

cagtcaatct ccaagcagca cannnaccct gcgaccgnag atgtgcatgc catgggagcc     1800

ttacctggaa tggtgtggca agacagagac gtatacctgc agggtcctat ttgggccaaa     1860

attcctcaca cggatggaca ctttcacccg tctcctctca tgggcggctt tggacttaag     1920

cacccgcctc ctcagatcct catcaaaaac acgcctgttc ctgcgaatcc tccggcagag     1980

ttttcggcta caaagtttgc ttcattcatc acccagtatt ccacaggaca agtgagcgtg     2040

gagattgaat gggagctgca gaaagaaaac agcaaacgct ggaatcccga agtgcagtat     2100

acatctaact atgcaaaatc tgccaacgtt gatttcactg tggacaacaa tggactttat     2160

actgagcctc gccccattgg cacccgttac ctcacccgtc cccngtaa                  2208


<210> 5204
<211> 723
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5204
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Val Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Gln Val 
305                 310                 315                 320 


Lys Glu Thr Thr Asp Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Thr Ser Tyr Thr Phe Glu Asp Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr Gln Asn Gln Ser 
        435                 440                 445             


Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser Arg Gly Ser Pro Thr 
    450                 455                 460                 


Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg 
465                 470                 475                 480 


Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn Asn Asn Ser Asn Phe 
                485                 490                 495     


Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn Gly Arg Glu Ser Ile 
            500                 505                 510         


Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys Asp Asp Glu Asp Lys 
        515                 520                 525             


Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly Lys Glu Ser Ala Gly 
    530                 535                 540                 


Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile Thr Asp Glu Glu Ala 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Arg Phe Gly Thr Val Ala Val Asn Leu 
                565                 570                 575     


Gln Ser Ser Pro Ala Thr Asp Val His Ala Met Gly Ala Leu Pro Gly 
            580                 585                 590         


Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala 
        595                 600                 605             


Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly 
    610                 615                 620                 


Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr 
625                 630                 635                 640 


Pro Val Pro Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu 
            660                 665                 670         


Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln 
        675                 680                 685             


Tyr Thr Ser Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp 
    690                 695                 700                 


Asn Asn Gly Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


Thr Arg Pro 
            


<210> 5205
<211> 2208
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5205
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctatgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggtc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaagttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggtaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacagacgct ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca agtgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga agttcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 5206
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5206
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Lys Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asp Ala Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Ser Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5207
<211> 2208
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5207
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctatgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcaaac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaagttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcgggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggtaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacagacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca agtgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac gaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga agttcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

acagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 5208
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5208
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asn Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Lys Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Arg Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asp Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Ser Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5209
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5209
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt cgacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg actttaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaata actggggatt ccggcccaag agactcagct tcaagctctt caacatccag      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgat     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acggacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcactcaat actccacagg acaagtgagc     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5210
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5210
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5211
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5211
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Lys Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asp Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asn Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Ser Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Gln 
                725                 730                 735 


<210> 5212
<211> 2208
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5212
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctatgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggaacgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaagttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggtaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacagacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cggaaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca agtgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga agttcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atcagtaa                  2208


<210> 5213
<211> 2208
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5213
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctatgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg atccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaagttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtatgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggtaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacagacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca agtgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga agttcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 5214
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5214
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Lys Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asp Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Ser Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5215
<211> 2172
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5215
atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag       60

tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa      120

gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga      180

ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag      240

cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag      300

gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc      360

aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc      420

ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc      480

aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc      540

ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca      600

ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc      660

gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc      720

agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc      780

aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc      840

cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg      900

tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc      960

accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag     1020

ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc     1080

tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc     1140

gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac     1200

aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt     1260

cagaacctgt tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc     1320

acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc     1380

tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg     1440

gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg     1500

agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc     1560

tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc     1620

acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc     1680

gtggcgtaca acgtcggcgg gcagatggcc accaacaacc agagctccac cactgccccc     1740

gcgaccggca cgtacaacct ccaggaaatc gtgcccggca gcgtgtggat ggagagggac     1800

gtgtacctcc aaggacccat ctgggccaag atcccagaga cgggggcgca ctttcacccc     1860

tctccggcca tgggcggatt cggactcaaa cacccaccgc ccatgatgct catcaagaac     1920

acgcctgtgc ccggaaatat caccagcttc tcggacgtgc ccgtcagcag cttcatcacc     1980

cagtacagca ccgggcaggt caccgtggag atggagtggg agctcaagaa ggaaaactcc     2040

aagaggtgga acccagagat ccagtacaca aacaactaca acgaccccca gtttgtggac     2100

tttgccccgg acagcaccgg ggaatacaga accaccagac ctatcggaac ccgatacctt     2160

acccgacccc tt                                                         2172


<210> 5216
<211> 2214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5216
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgcc tgagcggacg gcgatgagtc ttccgggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt     1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa     2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctg           2214


<210> 5217
<211> 738
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5217
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Pro Glu Arg Thr Ala Met 
            580                 585                 590         


Ser Leu Pro Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5218
<211> 2214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5218
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgag ttttagtcgt gcggttcttt gtgatggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt     1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa     2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctg           2214


<210> 5219
<211> 738
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5219
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Ser Phe Ser Arg Ala Val 
            580                 585                 590         


Leu Cys Asp Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5220
<211> 2215
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5220
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg ctgcaggcgg tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta cggctaccta     1140

acactcaaca acggtagtca ggccgtggga cgctcctcct tctactgcct ggaatacttt     1200

ccttcgcaga tgctgagaac cggcaacaac ttccagttta cttacacctt cgaggacgtg     1260

cctttccaca gcagctacgc ccacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacgac aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca gcagcgagta tcaaagacat ctgcggataa caacaacagt     1500

gaatactcgt ggactggagc taccaagtac cacctcaatg gcagagactc tctggtgaat     1560

ccgggcccgg ccatggcaag ccacaaggac gatgaagaaa agtttttttc ctcagagcgg     1620

ggttctcatc tttgggaagc aaggctcaga gaaaacaaat gtggacattg aaaaggtcat     1680

gattacagac gaagaggaaa tcaggacaac caatcccgtg gctacggagc agtatggttc     1740

tgtatctacc aacctccaga gaggcaacag acaagcagct accgcagatg tcaacacaca     1800

aggcgttctt ccaggcatgg tctggcagga cagagatgtg taccttcagg ggcccatctg     1860

ggcaaagatt ccacacacgg acggacattt tcacccctct cccctcatgg gtggattcgg     1920

acttaaacac cctccgcctc agatcctgat caagaacacg cctgtacctg cggatcctcc     1980

gaccaccttc aaccagtcaa agctgaactc tttcatcacc cagtattcta ctggccaagt     2040

cagcgtggag atcgagtggg agctgcagaa ggaaaacagc aagcgctgga accccgagat     2100

ccagtacacc tccaactact acaaatctac aagtgtggac tttgctgtta atacagaagg     2160

cgtgtactct gaaccccgcc ccattggcac ccgttacctc acccgtaatc tgtaa          2215


<210> 5221
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5221
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ala Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Lys Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp 
                485                 490                 495     


Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala 
            580                 585                 590         


Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5222
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5222
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ala Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Lys Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp 
                485                 490                 495     


Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Gln Gly Asn Thr Gln Ala 
            580                 585                 590         


Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5223
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5223
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ala Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp 
                485                 490                 495     


Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Gln Gly Asn Thr Gln Ala 
            580                 585                 590         


Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5224
<211> 2214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5224
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatggg      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcgcac     1080

cagggctgcc tccctccgtt cccggcggac gtgttcatga ttccgcaata cggctacctg     1140

acgctcaaca atggcagcca agccgtggga cgttcatcct tttactgcct ggaatatttc     1200

ccttctcaga tgctgagaac gggcaacaac tttaccttca gctacacctt tgaggaagtg     1260

cctttccaca gcagctacgc gcacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacgaggagc gtttttttcc cagtaacggg     1620

atcctgattt ttggcaaaca aaatgctgcc agagacaatg cggattacag cgatgtcatg     1680

ctcaccagcg aggaagaaat caaaaccact aaccctgtgg ctacagagga atacggtatc     1740

gtggcagata acttgcagca gcaaaacacg gctcctcaaa ttggaactgt caacagccag     1800

ggggccttac ccggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttc cacccgtctc cgctgatggg cggctttggc     1920

ctgaaacatc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcacgc aatacagcac cggacaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatc     2100

cagtacactt ccaactatta caagtctaat aatgttgaat ttgctgttaa tactgaaggt     2160

gtatatagtg aaccccgccc cattggcacc agatacctga ctcgtaatct gtaa           2214


<210> 5225
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5225
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His 
        515                 520                 525             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met 
545                 550                 555                 560 


Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro 
            580                 585                 590         


Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5226
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5226
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ctgccgtacg ttctcggctc tgcccaccag     1080

ggctgcctgc ctccgttccc ggcggacgtg ttcatgattc cccagtacgg ctacctaaca     1140

ctcaacaacg gtagtcaggc cgtgggacgc tcctccttct actgcctgga atactttcct     1200

tcgcagatgc tgagaaccgg caacaacttc cagtttactt acaccttcga ggacgtgcct     1260

ttccacagca gctacgccca cagccagagc ttggaccggc tgatgaatcc tctgattgac     1320

cagtacctgt actacttgtc tcggactcaa acaacaggag gcacggcaaa tacgcagact     1380

ctgggcttca gccaaggtgg gcctaataca atggccaatc aggcaaagaa ctggctgcca     1440

ggaccctgtt accgccaaca acgcgtctca acgacaaccg ggcaaaacaa caatagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5227
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5227
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe Ser 
    450                 455                 460                 


Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5228
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5228
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcga       60

gagtggtggg cgctgcaacc tggagcccct aaacccaagg caaatcaaca acatcaggac      120

aacgctcggg gtcttgtgct tccgggttac aaatacctcg gacccggcaa cggactcgac      180

aagggggaac ccgtcaacgc agcggacgcg gcagccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggtga caacccctac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca ccagaacctg ggccctgccc acttacaaca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcagcttca agctcttcaa catccaagtt      960

aaagaggtca cgcagaacga tggcacgacg actattgcca ataaccttac cagcacggtt     1020

caagtgttta cggactcgga gtatcagctc ccgtacgtgc tcgggtcggc gcaccaaggc     1080

tgtctcccgc cgtttccagc ggacgtcttc atggtccctc agtatggata cctcaccctg     1140

aacaacggaa gtcaagcggt gggacgctca tccttttact gcctggagta cttcccttcg     1200

cagatgctaa ggactggaaa taacttccaa ttcagctata ccttcgagga tgtacctttt     1260

cacagcagct acgctcacag ccagagtttg gatcgcttga tgaatcctct tattgatcag     1320

tatctgtact acctgaacag aacgcaagga acaacctctg gaacaaccaa ccaatcacgg     1380

ctgcttttta gccaggctgg gcctcagtct atgtctttgc aggccagaaa ttggctacct     1440

gggccctgct accggcaaca gagactttca aagactgcta acgacaacaa caacagtaac     1500

tttccttgga cagcggccag caaatatcat ctcaatggcc gcgactcgct ggtgaatcca     1560

ggaccagcta tggccagtca caaggacgat gaagaaaaat ttttccctat gcacggcaat     1620

ctaatatttg gcaaagaagg gacaacggca agtaacgcag aattagataa tgtaatgatt     1680

acggatgaag aagagattcg taccaccaat cctgtggcaa cagagcagta tggaactgtg     1740

gcaaataact tgcagagctc aaatacagct cccacgacta gaactgtcaa tgatcagggg     1800

gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca     1860

aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg     1920

aaacatccgc ctcctcaaat catgatcaaa aatactccgg taccggcaaa tcctccgacg     1980

actttcagcc cggccaagtt tgcttcattt atcactcagt actccactgg acaggtcagc     2040

gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agagattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtagacac taatggtgtt     2160

tatagtgaac ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 5229
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5229
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5230
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5230
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgctaaaaag agactcaatt ttggtcagac tggcgactca      540

gagtcagtcc ccgacccaca acctctcgga gaacctccag caacccccgc tgctgtggga      600

cctactacaa tggcttcagg cggtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctggg cgacagagtc      720

atcaccacca gcaccagaac ctgggccctg cccacttaca acaaccatct ctacaagcaa      780

atctccagcc aatcaggagc ttcaaacgac aaccactact ttggctacag caccccttgg      840

gggtattttg actttaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacaaca actggggatt ccgacccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagt ctggaccgtc tcatgaatcc tctcatcgac     1320

cagtacctgt attacttgag cagaacaaac actccaagtg gaaccaccac gcagtcaagg     1380

cttcagtttt ctcaggccgg agcgagtgac attcgggacc agtctaggaa ctggcttcct     1440

ggaccctgtt accgccagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 5231
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5231
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser 
    450                 455                 460                 


Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5232
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5232
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagcccct aaacccaagg caaatcaaca acatcaggac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgctaaaaag agactcaatt ttggtcagac tggcgactca      540

gagtcagtcc ccgacccaca acctctcgga gaacctccag caacccccgc tgctgtggga      600

cctactacaa tggcttcagg cggtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctggg cgacagagtc      720

atcaccacca gcaccagaac ctgggccctg cccacttaca acaaccatct ctacaagcaa      780

atctccagcc aatcaggagc ttcaaacgac aaccactact ttggctacag caccccttgg      840

gggtattttg actttaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacaaca actggggatt ccgacccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagt ctggaccgtc tcatgaatcc cctcatcgac     1320

cagtacctgt attacttgag cagaacaaac actccaagtg gaaccaccac gcagtcaagg     1380

cttcagtttt ctcaggccgg agcgagtgac attcgggacc agtctaggaa ctggcttcct     1440

ggaccctgtt accggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtgtacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5233
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5233
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser 
    450                 455                 460                 


Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5234
<211> 2214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5234
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatggg      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat gactggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcgcac     1080

cagggctgcc tccctccgtt cccggcggac gtgttcatga ttccgcaata cggctacctg     1140

acgctcaaca atggcagcca agccgtggga cgttcatcct tttactgcct ggaatatttc     1200

ccttctcaga tgctgagaac gggcaacaac tttaccttca gctacacctt tgaggaagtg     1260

cctttccaca gcagctacgc gcacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacgaggagc gtttttttcc cagtaacggg     1620

atcctgattt ttggcaaaca aaatgctgcc agagacaatg cggattacag cgatgtcatg     1680

ctcaccagcg aggaagaaat caaaaccact aaccctgtgg ctacagagga atacggtatc     1740

gtggcagata acttgcagca gcaaaacacg gctcctcaaa ttggaactgt caacagccag     1800

ggggccttac ccggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttc cacccgtctc cgctgatggg cggctttggc     1920

ctgaaacatc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcacgc aatacagcac cggacaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatc     2100

cagtacactt ccaactatta caagtctaat aatgttgaat ttgctgttaa tactgaaggt     2160

gtatatagtg aaccccgccc cattggcacc agatacctga ctcgtaatct gtaa           2214


<210> 5235
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5235
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn Thr 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe Ser 
    450                 455                 460                 


Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His Lys 
        515                 520                 525             


Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met Leu 
545                 550                 555                 560 


Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro Gln 
            580                 585                 590         


Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5236
<211> 2214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5236
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatggg      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcgcac     1080

cagggctgcc tccctccgtt cccggcggac gtgttcatga ttccgcaata cggctacctg     1140

acgctcaaca atggcagcca agccgtggga cgttcatcct tttactgcct ggaatatttc     1200

ccttctcaga tgctgagaac gggcaacaac tttaccttca gctacacctt tgaggaagtg     1260

ccttttcaca gcagctacgc gcacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacgaggagc gtttttttcc cagtaacggg     1620

atcctgattt ttggcaaaca aaatgctgcc agagacaatg cggattacag cgatgtcatg     1680

ctcaccagcg aggaagaaat caaaaccact aaccctgtgg ctacagagga atacggtatc     1740

gtggcagata acttgcagca gcaaaacacg gctcctcaaa ttggaactgt caacagccag     1800

ggggccttac ccggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttc cacccgtctc cgctgatggg cggctttggc     1920

ctgaaacatc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcacgc aatacagcac cggacaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatc     2100

cagtacactt ccaactatta caagtctaat aatgttgaat ttgctgttaa tactgaaggt     2160

gtatatagtg aaccccgccc cattggcacc agatacctga ctcgtaatct gtaa           2214


<210> 5237
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5237
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His 
        515                 520                 525             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met 
545                 550                 555                 560 


Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro 
            580                 585                 590         


Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5238
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5238
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagcccct aaacccaagg caaatcaaca acatcaggac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgctaaaaag agactcaatt ttggtcagac tggcgactca      540

gagtcagtcc ccgacccaca acctctcgga gaacctccag caacccccgc tgctgtggga      600

cctactacaa tggcttcagg cggtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctggg cgacagagtc      720

atcaccacca gcaccagaac ctgggccctg cccacttaca acaaccatct ctacaagcaa      780

atctccagcc aatcaggagc ttcaaacgac aaccactact ttggctacag caccccttgg      840

gggtattttg actttaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacaaca actggggatt ccgacccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagt ctggaccgtc tcatgaatcc tctcatcgac     1320

cagtacctgt attacttgag cagaacaaac actccaagtg gaaccaccac gcagtcaagg     1380

cttcagtttt ctcaggccgg agcgagtgac attcgggacc agtctaggaa ctggcttcct     1440

ggaccctgtt accgccagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 5239
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5239
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser 
    450                 455                 460                 


Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5240
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5240
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc cggtcaacga ggcggacgcg gcagccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctccc      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctctac gggcatcggc      480

aagaaaggcc aacagcccgc cagaaaaaga ctcaatttcg gtcagactgg cgactcagag      540

tcagttccag accctcaacc tctcggagaa cctccagcag cgccctctgg tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aacacctact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt accttcagct acaccttcga ggacgtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5241
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5241
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Thr Gly Ile Gly 
145                 150                 155                 160 


Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn Thr 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5242
<211> 2205
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5242
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagtccct caacccaaag cgaaccaaca acaccaggac      120

aaccgtcggg gtcttgtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc cggtcaacga ggcggacgcg gcagccctcg aacacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca gcgactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctcttcaa catccaggtc      960

aaagaggtta cggacaacaa tggagtcaag accatcgcca ataaccttac cagcacggtc     1020

caggtcttca cggactcaga ctatcagctc ccgtacgtgc tcgggtcggc tcacgagggc     1080

tgcctcccgc cgttcccagc ggacgttttc atgattcctc agtacgggta tctgacgctt     1140

aatgatggaa gccaggccgt gggtcgttcg tccttttact gcctggaata tttcccgtcg     1200

caaatgctaa gaacgggtaa caacttccag ttcagctacg agtttgagaa cgtacctttc     1260

catagcagct acgctcacag ccaaagcctg gaccgactaa tgaatccact catcgaccaa     1320

tacttgtact atctctcaaa gactattaac ggttctggac agaatcaaca aacgctaaaa     1380

ttcagtgtgg ccggacccag caacatggct gtccagggaa gaaactacat acctggaccc     1440

agctaccgac aacaacgtgt ctcaaccact gtgactcaaa acaacaacag cgaatttgct     1500

tggcctggag cttcttcttg ggctctcaat ggacgtaata gcttgatgaa tcctggacct     1560

gctatggcca gccacaaaga aggagaggac cgtttctttc ctttgtctgg atctttaatt     1620

tttggcaaac aaggaactgg aagagacaac gtggatgcgg acaaagtcat gataaccaac     1680

gaagaagaaa ttaaaactac taacccggta gcaacggagt cctatggaca agtggccaca     1740

aaccaccaga gtgcccaagc acaggcgcag accggctggg ttcaaaacca aggaatactt     1800

ccgggtatgg tttggcagga cagagatgtg tacctgcaag gacccatctg ggccaagatt     1860

cctcacacgg acggcaactt ccacccgtct ccgctgatgg gcggctttgg cctgaaacat     1920

cctccgcctc agatcctgat caagaacacg cctgtacctg cggatcctcc gaccaccttc     1980

aaccagtcaa agctgaactc tttcatcacg caatacagca ccggacaggt cagcgtggaa     2040

attgaatggg agctgcagaa ggaaaacagc aagcgctgga atcccgaagt gcagtataca     2100

tctaactatg caaaatctgc caacgttgat ttcactgtgg acaacaatgg actttatact     2160

gagcctcgcc ccattggcac ccgttacctc acccgtcccc tgtaa                     2205


<210> 5243
<211> 734
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5243
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe Glu 
                405                 410                 415     


Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser Val Ala 
    450                 455                 460                 


Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly Pro 
465                 470                 475                 480 


Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Asn Asn 
                485                 490                 495     


Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly Arg 
            500                 505                 510         


Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu Gly 
        515                 520                 525             


Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys Gln 
    530                 535                 540                 


Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr Asn 
545                 550                 555                 560 


Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr Gly 
                565                 570                 575     


Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln Thr Gly 
            580                 585                 590         


Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro 
                645                 650                 655     


Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr Ala 
    690                 695                 700                 


Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu Tyr Thr 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 


<210> 5244
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5244
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagt gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

accgacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5245
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5245
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Trp Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5246
<211> 2214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5246
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatggg      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctcggcgcac     1080

cagggctgcc tccctccgtt cccggcggac gtcttcatgg tgccacagta tggatacctg     1140

acgctcaaca atggcagcca agccgtggga cgttcatcct tttactgcct ggaatatttc     1200

ccttctcaga tgctgagaac gggcaacaac tttaccttca gctacacctt tgaggaagtg     1260

cctttccaca gcagctacgc gcacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacgaggagc gtttttttcc cagtaacggg     1620

atcctgattt ttggcaaaca aaatgctgcc agagacaatg cggattacag cgatgtcatg     1680

ctcaccagcg aggaagaaat caaaaccact aaccctgtgg ctacagagga atacggtatc     1740

gtggcagata acttgcagca gcaaaacacg gctcctcaaa ttggaactgt caacagccag     1800

ggggacttac ccggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttc cacccgtctc cgctgatggg cggctttggc     1920

ctgaaacatc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcacgc aatacagcac cggacaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatc     2100

cagtacactt ccaactatta caagtctaat aatgttgaat ttgctgttaa tactgaaggt     2160

gtatatagtg aaccccgccc cattggcacc agatacctga ctcgtaatct gtaa           2214


<210> 5247
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5247
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His 
        515                 520                 525             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met 
545                 550                 555                 560 


Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro 
            580                 585                 590         


Gln Ile Gly Thr Val Asn Ser Gln Gly Asp Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5248
<211> 2205
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5248
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagtccct caacccaaag cgaaccaaca acaccaggac      120

aactgtcggg gtcttgtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc cggtcaacga ggcggacgcg gcagccctcg aacacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

accaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca gcgactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctcttcaa catccaggtc      960

aaagaggtta cggacaacaa tggagtcaag accatcgcca ataaccttac cagcacggtc     1020

caggtcttca cggactcaga ctatcagctc ccgtacgtgc tcgggtcggc tcacgagggc     1080

tgcctcccgc cgttcccagc ggacgttttc atgattcctc agtacgggta tctgacgctt     1140

aatgatggaa gccaggccgt gggtcgttcg tccttttact gcctggaata tttcccgtcg     1200

caaatgctaa gaacgggtaa caacttccag ttcagctacg agtttgagaa cgtacctttc     1260

catagcagct acgctcacag ccaaagcctg gaccgactaa tgaatccact catcgaccaa     1320

tacttgtact atctctcaaa gactattaac ggttctggac agaatcaaca aacgctaaaa     1380

ttcagtgtgg ccggacccag caacatggct gtccagggaa gaaactacat acctggaccc     1440

agctaccgac aacaacgtgt ctcaaccact gtgactcaaa acaacaacag cgaatttgct     1500

tggcctggag cttcttcttg ggctctcaat ggacgtaata gcttgatgaa tcctggacct     1560

gctatggcca gccacaaaga aggagaggac cgtttctttc ctttgtctgg atctttaatt     1620

tttggcaaac aaggaactgg aagagacaac gtggatgcgg acaaagtcat gataaccaac     1680

gaagaagaaa ttaaaactac taacccggta gcaacggagt cctatggaca agtggccaca     1740

aaccaccaga gtgcccaagc acaggcgcag accggctggg ttcaaaacca aggaatactt     1800

ccgggtatgg tttggcagga cagagatgtg tacctgcaag gacccatctg ggccaagatt     1860

cctcacacgg acggcaactt ccacccgtct ccgctgatgg gcggctttgg cctgaaacat     1920

cctccgcctc agatcctgat caagaacacg cctgttcctg cgaatcctcc ggcggagttt     1980

tcagctacaa agtttgcttc attcatcacc cagtactcca caggacaagt gagtgtggaa     2040

attgaatggg agctgcagaa agaaaacagc aagcgctgga atcccgaagt gcagtacaca     2100

tccaattatg caaaatctgc caacgttgat tttactgtgg acaacaatgg actttatact     2160

gagcctcgcc ccattggcac ccgttacctt accaaacctc tgtaa                     2205


<210> 5249
<211> 734
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5249
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Cys Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Thr Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe Glu 
                405                 410                 415     


Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser Val Ala 
    450                 455                 460                 


Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly Pro 
465                 470                 475                 480 


Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Asn Asn 
                485                 490                 495     


Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly Arg 
            500                 505                 510         


Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu Gly 
        515                 520                 525             


Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys Gln 
    530                 535                 540                 


Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr Asn 
545                 550                 555                 560 


Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr Gly 
                565                 570                 575     


Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln Thr Gly 
            580                 585                 590         


Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr Ala 
    690                 695                 700                 


Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu Tyr Thr 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Lys Pro Leu 
                725                 730                 


<210> 5250
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5250
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagcccct aaacccaagg caaatcaaca acatcaggac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgctaaaaag agactcaatt ttggtcagac tggcgactca      540

gagtcagtcc ccgacccaca acctctcgga gaacctccag caacccccgc tgctgtggga      600

cctactacaa tggcttcagg cggtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctggg cgacagagtc      720

atcaccacca gcaccagaac ctgggccctg cccacttaca acaaccatct ctacaagcaa      780

atctccagcc aatcaggagc ttcaaacgac aaccactact ttggctacag caccccttgg      840

gggtattttg actttaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacaaca actggggatt ccgacccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagt ctggaccgtc tcatgaatcc tctcatcgac     1320

cagtacctgt attacttgag cagaacaaac actccaagtg gaaccaccac gcagtcaagg     1380

cttcagtttt ctcaggccgg agcgagtgac attcgggacc agtctaggaa ctggcttcct     1440

ggaccctgtt accgccagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 5251
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5251
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser 
    450                 455                 460                 


Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5252
<211> 2214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5252
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatggg      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcgcac     1080

cagggctgcc tccctccgtt cccggcggac gtgttcatga ttccgcaata cggctacctg     1140

acgctcaaca atggcagcca agccgtggga cgttcatcct tttactgcct ggaatatttc     1200

ccttctcaga tgctgagaac gggcaacaac tttaccttca gctacacctt tgaggaagtg     1260

cctttccaca gcagctacgc gcacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacgaggagc gtttttttcc cagtaacggg     1620

atcctgattt ttggcaaaca aaatgctgcc agagacaatg cggattacag cgatgtcatg     1680

ctcaccagcg aggaagaaat caaaaccact aaccctgtgg ctacagagga atacggtatc     1740

gtggcagata acttgcagca gcaaaacacg gctcctcaaa ttggaactgt caacagccag     1800

ggggccttac ccggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttc cacccgtctc cgctgatggg cggctttggc     1920

ctgaaacatc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcacgc aatacagcac cggacaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatc     2100

cagtacactt ccaactatta caagtctaat aatgttgaat ttgctgttaa tactgaaggt     2160

gtatatagtg aaccccgccc cattggcacc agatacctga ctcgtaatct gtaa           2214


<210> 5253
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5253
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His 
        515                 520                 525             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met 
545                 550                 555                 560 


Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro 
            580                 585                 590         


Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5254
<211> 2205
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5254
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagtccct caacccaaag cgaaccaaca acaccaggac      120

aaccgtcggg gtcttgtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc cggtcaacga ggcggacgcg gcagccctcg aacacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca gcgactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctcttcaa catccaggtc      960

aaagaggtta cggacaacaa tggagtcaag accatcgcca ataaccttac cagcacggtc     1020

caggtcttca cggactcaga ctatcagctc ccgtacgtgc tcgggtcggc tcacgagggc     1080

tgcctcccgc cgttcccagc ggacgttttc atgattcctc agtacgggta tctgacgctt     1140

aatgatggaa gccaggccgt gggtcgttcg tccttttact gcctggaata tttcccgtcg     1200

caaatgctaa gaacgggtaa caacttccag ttcagctacg agtttgagaa cgtacctttc     1260

catagcagct acgctcacag ccaaagcctg gaccgactaa tgaatccact catcgaccaa     1320

tacttgtact atctctcaaa gactattaac ggttctggac agaatcaaca aacgctaaaa     1380

ttcagtgtgg ccggacccag caacatggct gtccagggaa gaaactacat acctggaccc     1440

agctaccgac aacaacgtgt ctcaaccact gtgactcaaa acaacaacag cgaatttgct     1500

tggcctggag cttcttcttg ggctctcaat ggacgtaata gcttgatgaa tcctggacct     1560

gctatggcca gccacaaaga aggagaggac cgtttctttc ctttgtctgg atctttaatt     1620

tttggcaaac aaggaactgg aagagacaac gtggatgcgg acaaagtcat gataaccaac     1680

gaagaagaaa ttaaaactac taacccggta gcaacggagt cctatggaca agtggccaca     1740

aaccaccaga gtgcccaagc acaggcgcag accggctggg ttcaaaacca aggaatactt     1800

ccgggtatgg tttggcagga cagagatgtg tacctgcaag gacccatttg ggccaaaatt     1860

cctcacacgg acggcaactt tcacccttct ccgctgatgg gagggtttgg aatgaaacac     1920

ccgcctcctc agatcctcat caaaaacaca cctgtacctg cggatcctcc aacggccttc     1980

aacaaggaca agctgaactc tttcatcacc cagtattcta ctggccaagt cagcgtggag     2040

atcgagtggg agctgcagaa ggaaaacagc aagcgctgga accccgagat ccagtacacc     2100

tccaactact acaaatctac aagtgtggac tttgctgtta atacagaagg cgtgtactct     2160

gaaccccgcc ccattggcac ccgttacctc acccgtaatc tgtaa                     2205


<210> 5255
<211> 734
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5255
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe Glu 
                405                 410                 415     


Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser Val Ala 
    450                 455                 460                 


Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly Pro 
465                 470                 475                 480 


Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Asn Asn 
                485                 490                 495     


Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly Arg 
            500                 505                 510         


Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu Gly 
        515                 520                 525             


Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys Gln 
    530                 535                 540                 


Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr Asn 
545                 550                 555                 560 


Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr Gly 
                565                 570                 575     


Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln Thr Gly 
            580                 585                 590         


Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro 
                645                 650                 655     


Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr 
    690                 695                 700                 


Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210> 5256
<211> 2217
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5256
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgca gcagcaaaac acggctcctc aaattggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccct ctcccctcat gggtggattc     1920

ggacttaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa     2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctgtaa        2217


<210> 5257
<211> 738
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5257
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5258
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5258
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcga       60

gagtggtggg cgctgcaacc tggagcccct aaacccaagg caaatcaaca acatcaggac      120

aacgctcggg gtcttgtgct tccgggttac aaatacctcg gacccggcaa cggactcgac      180

aagggggaac ccgtcaacgc agcggacgcg gcagccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggtga caacccctac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca ccagaacctg ggccctgccc acttacaaca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcagcttca agctcttcaa catccaagtt      960

aaagaggtca cgcagaacga tggcacgacg actattgcca ataaccttac cagcacggtt     1020

caggtgttta cggactcgga gtatcagctc ccgtacgtgc tcgggtcggc gcaccaaggc     1080

tgtctcccgc cgtttccagc ggacgtcttc atggtccctc agtatggata cctcaccctg     1140

aacaacggaa gtcaagcggt gggacgctca tccttttact gcctggagta cttcccttcg     1200

cagatgctaa ggactggaaa taacttccaa ttcagctata ccttcgagga tgtacctttt     1260

cacagcagct acgctcacag ccagagtttg gatcgcttga tgaatcctct tattgatcag     1320

tatctgtact acctgaacag aacgcaagga acaacctctg gaacaaccaa ccaatcacgg     1380

ctgcttttta gccaggctgg gcctcagtct atgtctttgc aggccagaaa ttggctacct     1440

gggccctgct accggcaaca gagactttca aagactgcta acgacaacaa caacagtaac     1500

tttccttgga cagcggccag caaatatcat ctcaatggcc gcgactcgct ggtgaatcca     1560

ggaccagcta tggccagtca caaggacgat gaagaaaaat ttttccctat gcacggcaat     1620

ctaatatttg gcaaagaagg gacaacggca agtaacgcag aattagataa tgtaatgatt     1680

acggatgaag aagagattcg taccaccaat cctgtggcaa cagagcagta tggaactgtg     1740

gcaaataact tgcagagctc aaatacagct cccacgacta gaactgtcaa tgatcagggg     1800

gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca     1860

aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg     1920

aaacatccgc ctcctcaaat catgatcaaa aatactccgg taccggcaaa tcctccgacg     1980

actttcagcc cggccaagtt tgcttcattt atcactcagt actccactgg acaggtcagc     2040

gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agagattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtagacac taatggtgtt     2160

tatagtgaac ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 5259
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5259
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5260
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5260
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcga       60

gagtggtggg cgctgcaacc tggagcccct aaacccaagg caaatcaaca acatcaggac      120

aacgctcggg gtcttgtgct tccgggttac aaatacctcg gacccggcaa cggactcgac      180

aagggggaac ccgtcaacgc agcggacgcg gcagccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggtga caacccctac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca ccagaacctg ggccctgccc acttacaaca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcagcttca agctcttcaa catccaagtt      960

aaagaggtca cgcagaacga tggcacgacg actattgcca ataaccttac cagcacggtt     1020

caagtgttta cggactcgga gtatcagctc ccgtacgtgc tcgggtcggc gcaccaaggc     1080

tgtctcccgc cgtttccagc ggacgtcttc atggtccctc agtatggata cctcaccctg     1140

aacaacggaa gtcaagcggt gggacgctca tccttttact gcctggagta cttcccttcg     1200

cagatgctaa ggactggaaa taacttccaa ttcagctata ccttcgagga tgtacctttt     1260

cacagcagct acgctcacag ccagagtttg gatcgcttga tgaatcctct tattgatcag     1320

tatctgtact acctgaacag aacgcaagga acaacctctg gaacaaccaa ccaatcacgg     1380

ctgcttttta gccaggctgg gcctcagtct atgtctttgc aggccagaaa ttggctacct     1440

gggccctgct accggcaaca gagactttca aagactgcta acgacaacaa caacagtaac     1500

tttccttgga cagcggccag caaatatcat ctcaatggcc gcgactcgct ggtgaatcca     1560

ggaccagcta tggccagtca caaggacgat gaagaaaaat ttttccctat gcacggcaat     1620

ctaatatttg gcaaagaagg gacaacggca agtaacgcag aattagataa tgtaatgatt     1680

acggatgaag aagagattcg taccaccaat cctgtggcaa cagagcagta tggaactgtg     1740

gcaaataact tgcagagctc aaatacagct cccacgacta gaactgtcaa tgatcagggg     1800

gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca     1860

aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg     1920

aaacatccgc ctcctcaaat catgatcaaa aatactccgg taccggcaaa tcctccgacg     1980

actttcagcc cggccaagtt tgcttcattt atcactcagt actccactgg acaggtcagc     2040

gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agagattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtagacac taatggtgtt     2160

tatagtgaac ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 5261
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5261
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5262
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5262
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagtccct caacccaaag cgaaccaaca acaccaggac      120

aaccgtcggg gtcttgtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5263
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5263
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5264
<211> 2217
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5264
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca acggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaaccaccag cagcccccac aagtttggga      600

tctaatacaa tggcttcagg cggtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctggg cgacagagtc      720

atcaccacca gcacccgcac ctgggccttg cccacctaca ataaccacct ctacaagcaa      780

atctccagtg cttcaacggg ggccagcaac gacaaccact acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa ccgcttccac tgccacttct cgccaagaga ctggcaaaga      900

ctcatcaaca acaattgggg attccggccc aagagactca acttcaaact cttcaacatc      960

caagtcaagg aggtcacgac gaatgatggc gtcacgacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta tggatacctc     1140

accctgaaca acggaagtca agcggtggga cgctcatcct tttactgcct ggagtacttc     1200

ccttcgcaga tgctaaggac tggaaataac ttccaattca gctatacctt cgaggatgta     1260

ccttttcaca gcagctacgc tcacagccag agtttggatc gcttgatgaa tcctcttatt     1320

gatcagtatc tgtactacct gaacagaacg caaggaacaa cctctggaac aaccaaccaa     1380

tcacggctgc tttttagcca ggctgggcct cagtctatgt ctttgcaggc cagaaattgg     1440

ctacctgggc cctgctaccg gcaacagaga ctttcaaaga ctgctaacga caacaacaac     1500

agtaactttc cttggacagc agccagcaaa tatcatctca atggccgcga ctcgctggtg     1560

aatccaggac cagctatggc cagtcacaag gacgatgaag aaaaattttt ccctatgcac     1620

ggcaatctaa tatttggcaa agaagggaca acggcaagta acgcagaatt agataatgta     1680

atgattacgg atgaagaaga gattcgtacc accaatcctg tggcaacaga gcagtatgga     1740

actgtggcaa ataacttgca gagctcaaat acagctccca cgactagaac tgtcaatgat     1800

cagggggcct tacctggcat ggtgtggcaa gatcgtgacg tgtaccttca ggggcccatc     1860

tgggcaaaga ttccacacac ggacggacat tttcacccct ctcccctcat gggtggattc     1920

ggacttaaac accctcctcc gcagattctc atcaagaaca ccccggtacc tgcgaatcct     1980

tcgaccacct tcagtgcggc aaagtttgct tccttcatca cacagtactc cacgggacag     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggaaaaca gcaagcgctg gaacccggag     2100

atccagtaca cttccaacta ttacaagtct aataatgttg aatttgctgt taatactgaa     2160

ggtgtatata gtgaaccccg ccccattggc accagatacc tgactcgtaa tctgtaa        2217


<210> 5265
<211> 738
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5265
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Thr Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn 
                485                 490                 495     


Asp Asn Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser 
        515                 520                 525             


His Lys Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile 
    530                 535                 540                 


Phe Gly Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val 
545                 550                 555                 560 


Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala 
            580                 585                 590         


Pro Thr Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5266
<211> 2208
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5266
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg acttgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgatt tcaacagatt ccactgccac ttttcaccac gtgactggca gcgactcatc      900

aacaacaatt ggggattccg gcccaagaga ctcagcttca agctcttcaa catccaggtc      960

aaggaggtca cgcagaatga aggcaccaag accatcgcca ataaccttac cagcacggtt     1020

caagtgttta cggactcgga gtatcagctc ccgtacgtgc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct gattgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggactatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccg tctccgctga tgggcggctt tggcctgaaa     1920

catcctccgc ctcagatcct gatcaagaac acgcctgtac ctgcggatcc tccgaccacc     1980

ttcaaccagt caaagctgaa ctctttcatc actcagtatt ctactggcca agtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaagcgct ggaaccccga gatccagtac     2100

acctccaact actacaaatc tacaagtgtg gactttgctg ttaatacaga aggcgtgtac     2160

tctgaacccc gccccattgg cacccgttac ctcacccgta atctgtaa                  2208


<210> 5267
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5267
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Tyr Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp 
                645                 650                 655     


Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5268
<211> 2214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5268
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgatttcaa cagattccac tgccatttct caccacgtga ctggcagcga      900

ctcatcaaca acaattgggg attccggccc aagagactca acttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta cggctaccta     1140

acactcaaca acggtagtca ggccgtggga cgctcctcct tctactgcct ggaatacttt     1200

ccttcgcaga tgctgagaac cggcaacaac ttccagttta cttacacctt cgaggacgtg     1260

cctttccaca gcagctacgc ccacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacgac aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca gcagcgagta tcaaagacat ttgcggataa caacaacagt     1500

gaatactcgt ggactggagc taccaagtac cacctcaatg gcagagactc tctggtgaat     1560

ccgggcccgg ccatggcaag ccacaaggac gatgaagaaa agttttttcc tcagagcggg     1620

gttctcatct ttgggaagca aggctcagag aaaacaaatg tggacattga aaaggtcatg     1680

attacagacg aagaggaaat caggacaacc aatcccgtgg ctacggagca gtatggttct     1740

gtatctacca acctccagag aggcaacaga caagcagcta ccgcagatgt caacacacaa     1800

ggcgttcttc caggcatggt ctggcaggac agagatgtgt accttcaggg gcccatctgg     1860

gcaaagattc cacacacgga cggacatttt cacccctctc ccctcatggg tggattcgga     1920

cttaaacacc ctccgcctca gatcctgatc aagaacacgc ctgtacccgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcaccc agtattctac tggccaagtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa ccccgagatc     2100

cagtacacct ccaactacta caaatctaca agtgtggact ttgctgttaa tacagaaggc     2160

gtgtactctg aaccccgccc cattggcacc cgttacctca cccgtaatct gtaa           2214


<210> 5269
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5269
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Phe Ala Asp 
                485                 490                 495     


Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala 
            580                 585                 590         


Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5270
<211> 2217
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5270
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaaccaccag cagcccccac aagtttggga      600

tctaatacaa tggcttcagg cggtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctggg cgacagagtc      720

atcaccacca gcacccgcac ctgggccttg cccacctaca ataaccacct ctacaagcaa      780

atctccagtg cttcaacggg ggccagcaac gacaaccact acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa ccgcttccac tgccacttct cgccaagaga ctggcaaaga      900

ctcatcaaca acaattgggg attccggccc aagagactca acttcaaact cttcaacatc      960

caagtcaagg aggtcacgac gaatgatggc gtcacgacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta tggatacctc     1140

accctgaaca acggaagtca agcggtggga cgctcatcct tttactgcct ggagtacttc     1200

ccttcgcaga tgctaaggac tggaaataac ttccaattca gctatacctt cgaggatgta     1260

ccttttcaca gcagctacgc tcacagccag agtttggatc gcttgatgaa tcctcttatt     1320

gatcagtatc tgtactacct gaacagaacg caaggaacaa cctctggaac aaccaaccaa     1380

tcacggctgc tttttagcca ggctgggcct cagtctatgt ctttgcaggc cagaaattgg     1440

ctacctgggc cctgctaccg gcaacagaga ctttcaaaga ctgctaacga caacaacaac     1500

agtaactttc cttggacagc agccagcaaa tatcatctca atggccgcga ctcgctggtg     1560

aatccaggac cagctatggc cagtcacaag gacgatgaag aaaaattttt ccctatgcac     1620

ggcaatctaa tatttggcaa agaagggaca acggcaagta acgcagaatt agataatgta     1680

atgattacgg atgaagaaga gattcgtacc accaatcctg tggcaacaga gcagtatgga     1740

actgtggcaa ataacttgca gagctcaaat acagctccca cgactagaac tgtcaatgat     1800

cagggggcct tacctggcat ggtgtggcaa gatcgtgacg tgtaccttca ggggcccatc     1860

tgggcaaaga ttccacacac ggacggacat tttcacccct ctcccctcat gggtggattc     1920

ggacttaaac accctcctcc gcagattctc atcaagaaca ccccggtacc tgcgaatcct     1980

tcgaccacct tcagtgcggc aaagtttgct tccttcatca cacagtactc cacgggacag     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggaaaaca gcaagcgctg gaacccggag     2100

atccagtaca cttccaacta ttacaagtct aataatgttg aatttgctgt taatactgaa     2160

ggtgtatata gtgaaccccg ccccattggc accagatacc tgactcgtaa tctgtaa        2217


<210> 5271
<211> 738
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5271
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn 
                485                 490                 495     


Asp Asn Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser 
        515                 520                 525             


His Lys Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile 
    530                 535                 540                 


Phe Gly Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val 
545                 550                 555                 560 


Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala 
            580                 585                 590         


Pro Thr Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5272
<211> 2208
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5272
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 5273
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5273
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5274
<211> 2208
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5274
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgcc gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc caaaaagaga ctcaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacagca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac gactactttg gctacagcac cccttggggg      840

tattttgatt tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgagg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 5275
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5275
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Ser Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn Asp Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Glu Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5276
<211> 2208
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5276
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttc      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttttcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcaacttca agctctttaa catccaggtc      960

aaggaggtca cgcagaatga aggcaccaag accatcgcca ataacctcac cagcaccatc     1020

caggtgttta cggactcgga gtaccagctg ccgtacgttc tcggctctgc ccaccagggc     1080

tgcctgcctc cgttcccggc ggacgtgttc atgattcccc agtacggcta cctaacactc     1140

aacaacggta gtcaggccgt gggacgctcc tccttctact gcctggaata ctttccttcg     1200

cagatgctga gaaccggcaa caacttccag tttacttaca ccttcgagga cgtgcctttc     1260

cacagcagct acgcccacag ccagagcttg gaccggctga tgaatcctct gattgaccag     1320

tacctgtatt acttgtctcg gactcaaaca acaggaggca cgacaaatac gcagactctg     1380

ggcttcagcc aaggtgggcc taatacaatg gccaatcagg caaagaactg gctgcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acagggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc agggtcccat ttgggccaaa     1860

attcctcaca cagatggaca ctttcacccg tcccctctta tgggcggctt tggactcaag     1920

aacccgcctc ctcagatcct catcaaaaac acgcctgttc ctgcgaatcc tccggcagag     1980

ttttcagcta caaagtttgc ttcattcatc acccaatact ccacaggaca agtgagtgtg     2040

gaaattgaat gggagctgca gaaagaaaac agcaagcgct ggaatcccga agtgcagtac     2100

acatccaatt atgcaaaatc tgccaacgtt gattttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctcacccgta atctgtaa                  2208


<210> 5277
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5277
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe Ser Gln 
    450                 455                 460                 


Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5278
<211> 2214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5278
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgatttcaa cagattccac tgccatttct caccacgtga ctggcagcga      900

ctcatcaaca acaattgggg attccggccc aagagactca acttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta cggctaccta     1140

acactcaaca acggtagtca ggccgtggga cgctcctcct tctactgcct ggaatacttt     1200

ccttcgcaga tgctgagaac cggcaacaac ttccagttta cttacacctt cgaggacgtg     1260

cctttccaca gcagctacgc ccacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacgac aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca gcagcgagta tcaaagacat ttgcggataa caacaacagt     1500

gaatactcgt ggactggagc taccaagtac cacctcaatg gcagagactc tctggtgaat     1560

ccgggcccgg ccatggcaag ccacaaggac gatgaagaaa agttttttcc tcagagcggg     1620

gttctcatct ttgggaagca aggctcagag aaaacaaatg tggacattga aaaggtcatg     1680

attacagacg aagaggaaat caggacaacc aatcccgtgg ctacggagca gtatggttct     1740

gtatctacca acctccagag aggcaacaga caagcagcta ccgcagatgt caacacacaa     1800

ggcgttcttc caggcatggt ctggcaggac agagatgtgt accttcaggg gcccatctgg     1860

gcaaagattc cacacacgga cggacatttt cacccctctc ccctcatggg tggattcgga     1920

cttaaacacc ctccgcctca gatcctgatc aagaacacgc ctgtacccgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcaccc agtattctac tggccaagtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa ccccgagatc     2100

cagtacacct ccaactacta caaatctaca agtgtggact ttgctgttaa tacagaaggc     2160

gtgtactctg aaccccgccc cattggcacc cgttacctca cccgtaatct gtaa           2214


<210> 5279
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5279
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Phe Ala Asp 
                485                 490                 495     


Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala 
            580                 585                 590         


Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5280
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5280
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5281
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5281
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Arg Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5282
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5282
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Ala Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5283
<211> 538
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5283
Met Arg Ala Ala Ala Gly Gly Asn Gly Gly Asp Ala Gly Gln Gly Ala 
1               5                   10                  15      


Glu Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
            20                  25                  30          


Ser Glu Ser His Val Thr Thr Thr Ser Thr Arg Thr Trp Val Leu Pro 
        35                  40                  45              


Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu Gly Ser Ser Asn Ala Ser 
    50                  55                  60                  


Asp Thr Phe Asn Gly Phe Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
65                  70                  75                  80  


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
                85                  90                  95      


Asn His Trp Gly Leu Arg Pro Lys Ser Met Gln Val Arg Ile Phe Asn 
            100                 105                 110         


Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu Thr Thr Val Ser 
        115                 120                 125             


Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp Ser Thr Tyr Glu 
    130                 135                 140                 


Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser Leu Pro Pro Phe 
145                 150                 155                 160 


Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Cys Gly Leu Val 
                165                 170                 175     


Thr Gly Gly Ser Ser Gln Asn Gln Thr Asp Arg Asn Ala Phe Tyr Cys 
            180                 185                 190         


Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu 
        195                 200                 205             


Met Val Tyr Lys Phe Glu Asn Val Pro Phe His Ser Met Tyr Ala His 
    210                 215                 220                 


Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Leu Asp Gln Tyr Leu 
225                 230                 235                 240 


Trp Glu Leu Gln Ser Thr Thr Ser Gly Gly Thr Leu Asn Gln Gly Asn 
                245                 250                 255     


Ser Ala Thr Asn Phe Ala Lys Leu Thr Lys Thr Asn Phe Ser Gly Tyr 
            260                 265                 270         


Arg Lys Asn Trp Leu Pro Gly Pro Met Met Lys Gln Gln Arg Phe Ser 
        275                 280                 285             


Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro Gln Gly Arg Asn Asn Ser 
    290                 295                 300                 


Leu Leu His Tyr Glu Thr Arg Thr Thr Leu Asp Gly Arg Trp Ser Asn 
305                 310                 315                 320 


Phe Ala Pro Gly Thr Ala Met Ala Thr Ala Ala Asn Asp Ala Thr Asp 
                325                 330                 335     


Phe Ser Gln Ala Gln Leu Ile Phe Ala Gly Pro Asn Ile Thr Gly Asn 
            340                 345                 350         


Thr Thr Thr Asp Ala Asn Asn Leu Met Phe Thr Ser Glu Asp Glu Leu 
        355                 360                 365             


Arg Ala Thr Asn Pro Arg Asp Thr Asp Leu Phe Gly His Leu Ala Thr 
    370                 375                 380                 


Asn Gln Gln Asn Ala Thr Thr Val Pro Thr Val Asp Asp Val Asp Gly 
385                 390                 395                 400 


Val Gly Val Tyr Pro Gly Met Val Trp Gln Asp Arg Asp Ile Tyr Tyr 
                405                 410                 415     


Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His 
            420                 425                 430         


Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys Ser Pro Pro Pro Gln 
        435                 440                 445             


Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ala Thr Thr Phe 
    450                 455                 460                 


Ser Pro Ala Arg Ile Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln 
465                 470                 475                 480 


Val Ala Val Lys Ile Glu Trp Glu Ile Gln Lys Glu Arg Ser Lys Arg 
                485                 490                 495     


Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly Ala Gln Asp Ser 
            500                 505                 510         


Leu Leu Trp Ala Pro Asp Asn Ala Gly Ala Tyr Lys Glu Pro Arg Ala 
        515                 520                 525             


Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
    530                 535             


<210> 5284
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5284
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Ser Ile Gly Asp 
1               5                   10                  15      


Gly Phe Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Asp Pro Val 
    50                  55                  60                  


Asn Phe Ala Asp Glu Val Ala Arg Glu His Asp Leu Ser Tyr Gln Lys 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Ser Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Thr Pro Asp Lys Thr Ala Pro Ala Ala Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Lys Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Asp Asp Glu 
                165                 170                 175     


Pro Gly Ala Gly Asp Gly Pro Pro Pro Glu Gly Pro Ser Ser Gly Ala 
            180                 185                 190         


Met Ser Thr Glu Thr Glu Met Arg Ala Ala Ala Gly Gly Asn Gly Gly 
        195                 200                 205             


Asp Ala Gly Gln Gly Ala Glu Gly Val Gly Asn Ala Ser Gly Asp Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Ser Glu Ser His Val Thr Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu 
                245                 250                 255     


Gly Ser Ser Asn Ala Ser Asp Thr Phe Asn Gly Phe Ser Thr Pro Trp 
            260                 265                 270         


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
        275                 280                 285             


Trp Gln Arg Leu Ile Asn Asn His Trp Gly Leu Arg Pro Lys Ser Met 
    290                 295                 300                 


Gln Val Arg Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn 
305                 310                 315                 320 


Gly Glu Thr Thr Val Ser Asn Asn Leu Thr Ser Thr Val His Ile Phe 
                325                 330                 335     


Ala Asp Ser Thr Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu 
            340                 345                 350         


Gly Ser Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr 
        355                 360                 365             


Gly Tyr Cys Gly Leu Val Thr Gly Gly Ser Ser Gln Asn Gln Thr Asp 
    370                 375                 380                 


Arg Asn Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Met Val Tyr Lys Phe Glu Asn Val Pro Phe 
                405                 410                 415     


His Ser Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Leu Asp Gln Tyr Leu Trp Glu Leu Gln Ser Thr Thr Ser Gly Gly 
        435                 440                 445             


Thr Leu Asn Gln Gly Asn Ser Ala Thr Asn Phe Ala Lys Leu Thr Asn 
    450                 455                 460                 


Lys Asn Phe Ser Gly Tyr Arg Lys Asn Trp Leu Pro Gly Pro Met Met 
465                 470                 475                 480 


Lys Gln Gln Arg Phe Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro 
                485                 490                 495     


Gln Gly Gly Asn Asn Ser Leu Leu His Tyr Glu Thr Arg Thr Thr Leu 
            500                 505                 510         


Asp Arg Arg Trp Ser Asn Phe Ala Pro Gly Thr Ala Met Ala Thr Ala 
        515                 520                 525             


Ala Asn Asp Ala Thr Asp Phe Ser Gln Ala Gln Leu Ile Phe Ala Gly 
    530                 535                 540                 


Pro Asn Ile Thr Gly Asn Thr Thr Thr Asp Ala Asn Asn Leu Met Phe 
545                 550                 555                 560 


Thr Ser Glu Asp Glu Leu Arg Ala Thr Asn Pro Arg Asp Thr Asp Leu 
                565                 570                 575     


Phe Gly His Leu Ala Thr Asn Gln Gln Asn Ala Thr Thr Val Pro Thr 
            580                 585                 590         


Val Asp Asp Val Asp Gly Val Gly Val Tyr Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Ser Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Ala Thr Thr Phe Ser Pro Ala Arg Ile Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ala Val Lys Ile Glu Trp Glu Ile Gln 
        675                 680                 685             


Lys Glu Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn 
    690                 695                 700                 


Tyr Gly Ala Gln Asp Ser Leu Leu Trp Ala Pro Asp Asn Ala Gly Ala 
705                 710                 715                 720 


Tyr Lys Glu Pro Arg Ala Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730                 735     


<210> 5285
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5285
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Ser Ile Gly Asp 
1               5                   10                  15      


Gly Phe Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Asp Pro Val 
    50                  55                  60                  


Asn Phe Ala Asp Glu Val Ala Arg Glu His Asp Leu Ser Tyr Gln Lys 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Ser Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Thr Pro Asp Lys Thr Ala Pro Ala Ala Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Lys Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Asp Asp Glu 
                165                 170                 175     


Pro Gly Ala Gly Asp Gly Pro Pro Pro Glu Gly Pro Ser Ser Gly Ala 
            180                 185                 190         


Met Ser Thr Glu Thr Glu Met Arg Ala Ala Ala Gly Gly Asn Gly Gly 
        195                 200                 205             


Asp Ala Gly Gln Gly Ala Glu Gly Val Gly Asn Ala Ser Gly Asp Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Ser Glu Ser His Val Thr Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu 
                245                 250                 255     


Gly Ser Ser Asn Ala Ser Asp Thr Phe Asn Gly Phe Ser Thr Pro Trp 
            260                 265                 270         


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
        275                 280                 285             


Trp Gln Arg Leu Ile Asn Asn His Trp Gly Leu Arg Pro Lys Ser Met 
    290                 295                 300                 


Gln Val Arg Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn 
305                 310                 315                 320 


Gly Glu Thr Thr Val Ser Asn Asn Leu Thr Ser Thr Val Gln Ile Phe 
                325                 330                 335     


Ala Asp Ser Thr Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu 
            340                 345                 350         


Gly Ser Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr 
        355                 360                 365             


Gly Tyr Cys Gly Leu Val Thr Gly Gly Ser Ser Gln Asn Gln Thr Asp 
    370                 375                 380                 


Arg Asn Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Met Val Tyr Lys Phe Glu Asn Val Pro Phe 
                405                 410                 415     


His Ser Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Leu Asp Gln Tyr Leu Trp Glu Leu Gln Ser Thr Thr Ser Gly Gly 
        435                 440                 445             


Thr Leu Asn Gln Gly Asn Ser Ala Thr Asn Phe Ala Lys Leu Thr Lys 
    450                 455                 460                 


Thr Asn Phe Ser Gly Tyr Arg Lys Asn Trp Leu Pro Gly Pro Met Met 
465                 470                 475                 480 


Lys Gln Gln Arg Phe Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro 
                485                 490                 495     


Gln Gly Arg Asn Asn Ser Leu Leu His Tyr Glu Thr Arg Thr Thr Leu 
            500                 505                 510         


Asp Gly Arg Trp Ser Asn Phe Ala Pro Gly Thr Ala Met Ala Thr Ala 
        515                 520                 525             


Ala Asn Asp Ala Thr Asp Phe Ser Gln Ala Gln Leu Ile Phe Ala Gly 
    530                 535                 540                 


Pro Asn Ile Thr Gly Asn Thr Thr Thr Asp Ala Asn Asn Leu Met Phe 
545                 550                 555                 560 


Thr Ser Glu Asp Glu Leu Arg Ala Thr Asn Pro Arg Asp Thr Asp Leu 
                565                 570                 575     


Phe Gly His Leu Ala Thr Asn Gln Gln Asn Ala Thr Thr Val Pro Thr 
            580                 585                 590         


Val Asp Asp Val Asp Gly Val Gly Val Tyr Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Ser Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Ala Thr Thr Phe Ser Pro Ala Arg Ile Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ala Val Lys Ile Glu Trp Glu Ile Gln 
        675                 680                 685             


Lys Glu Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn 
    690                 695                 700                 


Tyr Gly Ala Gln Asp Ser Leu Leu Trp Ala Pro Asp Asn Ala Gly Ala 
705                 710                 715                 720 


Tyr Lys Glu Pro Arg Ala Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730                 735     


<210> 5286
<211> 2214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5286
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta cggctaccta     1140

acactcaaca acggtagtca ggccgtggga cgctcctcct tctactgcct ggaatacttt     1200

ccttcgcaga tgctgagaac cggcaacaac ttccagttta cttacacctt cgaggacgtg     1260

cctttccaca gcagctacgc ccacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacaaggagc gtttttttcc cagtaacggg     1620

atcctgattt ttggcaaaca aaatgctgcc agagacaatg cggattacag cgatgtcatg     1680

ctcaccagcg aggaagaaat caaaaccact aaccctgtgg ctacagagga atacggtatc     1740

gtggcagata acttgcagca gcaaaacacg gctcctcaaa ttggaactgt caacagccag     1800

ggggccttac ccggtatggt ttggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttc cacccgtctc cgctgatggg cggctttggc     1920

ctgaaacatc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcacgc aatacagcac cggacaggtc     2040

agcgtggaaa ttgaatggga gctgcagaag gaaaacagca agcgctggaa ccccgagatc     2100

cagtacacct ccaactacta caaatctaca agtgtggact ttgctgttaa tacagaaggc     2160

gtgtactctg aaccccaccc cattggcacc cgttacctca cccgtcccct gtaa           2214


<210> 5287
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5287
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His 
        515                 520                 525             


Lys Asp Asp Lys Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met 
545                 550                 555                 560 


Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro 
            580                 585                 590         


Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro His Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210> 5288
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5288
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe Ser 
    450                 455                 460                 


Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His Lys 
        515                 520                 525             


Asp Asp Lys Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met Leu 
545                 550                 555                 560 


Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro Gln 
            580                 585                 590         


Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro His Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5289
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5289
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Glu Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe Ser 
    450                 455                 460                 


Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His Lys 
        515                 520                 525             


Asp Asp Lys Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met Leu 
545                 550                 555                 560 


Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro Gln 
            580                 585                 590         


Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro His Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5290
<211> 2181
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5290
atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag       60

tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa      120

gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga      180

ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag      240

cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag      300

gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc      360

aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc      420

ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc      480

aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc      540

ccagcacaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca      600

ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc      660

gattccacgt ggatggggga cagagtcgtc accaagtcca cccgcacctg ggtgctgccc      720

agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc      780

aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc      840

cactggagcc cccgagactg gcaaagactc atcaacaact attggggctt cagaccccgg      900

tctctcagag tcaaaatctt caacatccaa gtcaaagagg tcacggtgca ggactccacc      960

accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccaa     1020

ctcccgtacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc cccgcaggtc     1080

tttacgctgc cgcagtacgg ctacgcgacg ctgaaccgag acaacggaga caacccgaca     1140

gagcggagca gcttcttttg cctagagtac tttcccagca agatgctgag gacgggcaac     1200

aactttgagt ttacctacag ctttgaagag gtgcccttcc actgcagctt cgccccgagc     1260

cagaacctct ttaagctggc caacccgctg gtggaccagt acctgtaccg cttcgtgagc     1320

acctcggcca cgggcgccat ccagttccaa aagaacctgg cgggcagata cgccaacacc     1380

tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacac gagctctggg     1440

gtcagcagca ccaacagagt cagcgtcaac aacttttccg tctcaaaccg gatgaacctg     1500

gagggggcca gctaccaagt gaacccccag cccaacggga tgacaaacac gctccaaggc     1560

agcaaccgct acgcgctgga aaacaccatg atcttcaacg ctcaaaacgc cacgccggga     1620

actacctcgg tgtacccaga ggacaatcta ctgctgacca gcgagagcga gactcagccc     1680

gtcaaccggg tggcttacaa cacgggcggt cagatggcca ccaacgccca gaacgccacc     1740

acggctccca cggtcgggac ctacaacctc caggaagtgc ttcctggcag cgtatggatg     1800

gagagggacg tgtacctcca aggacccatc tgggccaaga tcccagagac gggggcgcac     1860

tttcacccct ctccggccat gggcggattc ggactcaaac acccgccgcc catgatgctc     1920

atcaaaaaca cgccggtgcc cggcaacatc accagcttct cggacgtgcc cgtcagcagc     1980

ttcatcaccc agtacagcac cgggcaggtc accgtggaga tggaatggga gctcaaaaag     2040

gaaaactcca agaggtggaa cccagagatc cagtacacca acaactacaa cgacccccag     2100

tttgtggact ttgctccaga cggctccggc gaatacagaa ccaccagagc catcggaacc     2160

cgatacctca cccgacccct t                                               2181


<210> 5291
<211> 726
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5291
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Gly Asp Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Ser Phe Glu Glu Val Pro Phe His Cys Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Ser Ala Thr Gly Ala Ile Gln 
        435                 440                 445             


Phe Gln Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Thr Ser Ser Gly 
465                 470                 475                 480 


Ser Ser Thr Asn Arg Val Ser Val Asn Asn Phe Ser Val Ser Asn Arg 
                485                 490                 495     


Met Asn Leu Glu Gly Ala Ser Tyr Gln Val Asn Pro Gln Pro Asn Gly 
            500                 505                 510         


Met Thr Asn Thr Leu Gln Gly Ser Asn Arg Tyr Ala Leu Glu Asn Thr 
        515                 520                 525             


Met Ile Phe Asn Ala Gln Asn Ala Thr Pro Gly Thr Thr Ser Val Tyr 
    530                 535                 540                 


Pro Glu Asp Asn Leu Leu Leu Thr Ser Glu Ser Glu Thr Gln Pro Val 
545                 550                 555                 560 


Asn Arg Val Ala Tyr Asn Thr Gly Gly Gln Met Ala Thr Asn Ala Gln 
                565                 570                 575     


Asn Ala Thr Thr Ala Pro Thr Val Gly Thr Tyr Asn Leu Gln Glu Val 
            580                 585                 590         


Leu Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 
        595                 600                 605             


Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 
    610                 615                 620                 


Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 
625                 630                 635                 640 


Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 
                645                 650                 655     


Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 
            660                 665                 670         


Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
        675                 680                 685             


Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 
    690                 695                 700                 


Pro Asp Gly Ser Gly Glu Tyr Arg Thr Thr Arg Ala Ile Gly Thr Arg 
705                 710                 715                 720 


Tyr Leu Thr Arg Pro Leu 
                725     


<210> 5292
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5292
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5293
<211> 1803
<212> DNA
<213> Bovine adeno-associated virus

<400> 5293
acggcgcctg cggcaaaaaa gaggcctcta gagcagagtc ctcaagagcc agactcctcg       60

agcggagttg gcaagaaagg caaacagcct gccagaaaga gactcaactt tgacgacgaa      120

cctggagccg gagacgggcc tcccccagaa ggaccatctt ccggagctat gtctactgag      180

actgaaatgc gtgcagcagc tggcggaaat ggtggcgatg cgggacaagg tgccgaggga      240

gtgggtaatg cctccggtga ttggcattgc gattccactt ggtcagagag ccacgtcacc      300

accacctcaa cccgcacctg ggtcctgccg acctacaaca accacctgta cctgcggctc      360

ggctcgagca acgccagcga caccttcaac ggattctcca ccccctgggg atactttgac      420

tttaaccgct tccactgcca cttctcgcca agagactggc aaaggctcat caacaaccac      480

tggggactgc gccccaaaag catgcaagtc cgcatcttca acatccaagt taaggaggtc      540

acgacgtcta acggggagac gaccgtatcc aacaacctca ccagcacggt ccagatcttt      600

gcggacagca cgtacgagct cccgtacgtg atggatgcag gtcaggaggg cagcttgcct      660

cctttcccca acgacgtgtt catggtgcct cagtacgggt actgcggact ggtaaccgga      720

ggcagctctc aaaaccagac agacagaaat gccttctact gtctggagta ctttcccagc      780

cagatgctga gaaccggaaa caactttgag atggtgtaca agtttgaaaa cgtgcccttc      840

cactccatgt acgctcacag ccagagcctg gataggctga tgaacccgct gctggaccag      900

tacctgtggg agctccagtc taccacctct ggaggaactc tcaaccaggg caattcagcc      960

accaactttg ccaagctgac caaaacaaac ttttctggct accgcaaaaa ctggctcccg     1020

gggcccatga tgaagcagca gagattctcc aagactgcca gtcaaaacta caagattccc     1080

cagggaagaa acaacagtct gctccattat gagaccagaa ctaccctcga cggaagatgg     1140

agcaattttg ccccgggaac ggccatggca accgcagcca acgacgccac cgacttctct     1200

caggcccagc tcatctttgc ggggcccaac atcaccggca acaccaccac agatgccaat     1260

aacctgatgt tcacttcaga agatgaactt agggccacca acccccggga cactgacctg     1320

tttggccacc tggcaaccaa ccagcaaaac gccaccaccg ttcctaccgt agacgacgtg     1380

gacggagtcg gcgtgtaccc gggaatggtg tggcaggaca gagacattta ctaccaaggg     1440

cccatttggg ccaaaattcc acacacggat ggacactttc acccgtctcc tctcattggc     1500

ggatttggac tgaaaagccc gcctccacaa atattcatca aaaacactcc tgtacccgcc     1560

aatcccgcaa cgaccttctc tccggccaga atcaacagct tcatcaccca gtacagcacc     1620

ggacaggtgg ctgtcaaaat agaatgggaa atccagaagg agcggtccaa gagatggaac     1680

ccagaggtcc agttcacgtc caactacgga gcacaggact cgcttctctg ggctcccgac     1740

aacgccggag cctacaaaga gcccagggcc attggatccc gatacctcac caaccacctc     1800

tag                                                                   1803


<210> 5294
<211> 1617
<212> DNA
<213> Bovine adeno-associated virus

<400> 5294
atgcgtgcag cagctggcgg aaatggtggc gatgcgggac aaggtgccga gggagtgggt       60

aatgcctccg gtgattggca ttgcgattcc acttggtcag agagccacgt caccaccacc      120

tcaacccgca cctgggtcct gccgacctac aacaaccacc tgtacctgcg gctcggctcg      180

agcaacgcca gcgacacctt caacggattc tccaccccct ggggatactt tgactttaac      240

cgcttccact gccacttctc gccaagagac tggcaaaggc tcatcaacaa ccactgggga      300

ctgcgcccca aaagcatgca agtccgcatc ttcaacatcc aagttaagga ggtcacgacg      360

tctaacgggg agacgaccgt atccaacaac ctcaccagca cggtccagat ctttgcggac      420

agcacgtacg agctcccgta cgtgatggat gcaggtcagg agggcagctt gcctcctttc      480

cccaacgacg tgttcatggt gcctcagtac gggtactgcg gactggtaac cggaggcagc      540

tctcaaaacc agacagacag aaatgccttc tactgtctgg agtactttcc cagccagatg      600

ctgagaaccg gaaacaactt tgagatggtg tacaagtttg aaaacgtgcc cttccactcc      660

atgtacgctc acagccagag cctggatagg ctgatgaacc cgctgctgga ccagtacctg      720

tgggagctcc agtctaccac ctctggagga actctcaacc agggcaattc agccaccaac      780

tttgccaagc tgaccaaaac aaacttttct ggctaccgca aaaactggct cccggggccc      840

atgatgaagc agcagagatt ctccaagact gccagtcaaa actacaagat tccccaggga      900

agaaacaaca gtctgctcca ttatgagacc agaactaccc tcgacggaag atggagcaat      960

tttgccccgg gaacggccat ggcaaccgca gccaacgacg ccaccgactt ctctcaggcc     1020

cagctcatct ttgcggggcc caacatcacc ggcaacacca ccacagatgc caataacctg     1080

atgttcactt cagaagatga acttagggcc accaaccccc gggacactga cctgtttggc     1140

cacctggcaa ccaaccagca aaacgccacc accgttccta ccgtagacga cgtggacgga     1200

gtcggcgtgt acccgggaat ggtgtggcag gacagagaca tttactacca agggcccatt     1260

tgggccaaaa ttccacacac ggatggacac tttcacccgt ctcctctcat tggcggattt     1320

ggactgaaaa gcccgcctcc acaaatattc atcaaaaaca ctcctgtacc cgccaatccc     1380

gcaacgacct tctctccggc cagaatcaac agcttcatca cccagtacag caccggacag     1440

gtggctgtca aaatagaatg ggaaatccag aaggagcggt ccaagagatg gaacccagag     1500

gtccagttca cgtccaacta cggagcacag gactcgcttc tctgggctcc cgacaacgcc     1560

ggagcctaca aagagcccag ggccattgga tcccgatacc tcaccaacca cctctag        1617


<210> 5295
<211> 1173
<212> DNA
<213> Bovine adeno-associated virus

<400> 5295
atggcgctgg taagctggct ggtggaacat ggcatcactt ccgagaagca gtggattcag       60

gagaatcagg agagctacct gtccttcaac tccacgggaa actctcggag ccagattaaa      120

gccgcgcttg acaacgcgtc aaaaattatg agtctgacca aatctgcctc agactatctc      180

gtgggacaga ctgttccaga ggacatttct gaaaacagaa tctggcagat ttttgatctc      240

aacggctacg acccggcata cgcgggctct gttctctacg gctggtgcac tcgcgccttt      300

ggaaagagga acaccgtctg gctgtatgga cccgcgacca ccggaaagac caacatcgcg      360

gaagccatct ctcacaccgt gcccttttat ggctgtgtga actggactaa tgagaacttt      420

ccctttaatg actgtgtgga aaaaatgttg atctggtggg aggagggaaa gatgaccagc      480

aaggtggtgg aacccgccaa ggccatcttg ggggggtcta gagtacgagt ggatcaaaaa      540

tgtaaatcct ctgtacaagt agactctacc ccggtgatta tcacctccaa tactaacatg      600

tgtgtggtgg tggatgggaa ctccacgacc tttgaacacc agcagccgct ggaagaccgc      660

atgttcagat ttgaactcat gcggcggctc ccgccagatt ttggcaagat taccaagcag      720

gaagtcaaag acttttttgc ttgggcaaag gtcaaccagg tgccggtgac tcacgagttt      780

atggttccca agaaagtggc gggaactgag agggcggaga cttctagaaa acgcccactg      840

gatgacgtca ccaataccaa ctataaaagt ccggagaagc gggcccggct ctcagttgtt      900

cctgagacgc ctcgcagttc agacgtgcct gtagagcccg ctcctctgcg acctctcaac      960

tggtcttcca ggtatgaatg cagatgtgac tatcatgcta aatttgactc tgtaacgggg     1020

gaatgtgacg agtgtgaata tttgaatcgg ggcaaaaatg gctgtatctt tcataatgct     1080

acacattgtc aaatttgtca cgctgttcct ccatgggaaa aggaaaatgt gtcagatttt     1140

aatgattttg atgactgtaa taaagagcag taa                                  1173


<210> 5296
<211> 1833
<212> DNA
<213> Bovine adeno-associated virus

<400> 5296
atggctacct tctatgaagt cattgttcgc gttccatttg atgtggaaga gcacctgcct       60

ggaatttctg acaactttgt agactgggta actggtcaaa tttgggagct gcctcccgag      120

tcagatttga atttgactct gattgagcag cctcagctga cggtggctga cagaattcgc      180

cgcgtgttcc tgtacgagtg gaacaaattt tccaagcagg agagcaaatt ctttgtgcag      240

tttgaaaagg gatctgaata ttttcatctg cacacgctcg tggagacctc cggcatctct      300

tctatggtcc ttggccgcta cgtgagtcag attcgcgccc agctggtgaa ggtggtgttc      360

cagaacattg agccgcggat taacgactgg gtcgccatca ccaaggtaaa gaagggcgga      420

gccaataagg tggtggattc tgggtatatt cccgcctacc tgctgccgaa ggtccaacca      480

gagcttcagt gggcgtggac taacctcgaa gagtataaat tggccgccct caatctggag      540

gagcgcaaac ggctcgtcgc tcagtttcag cttgagtcct cgcagcgctc gcaagaggca      600

tcttcccaga gggacgtttc ggctgacccg gtcatcaaga gcaagacttc ccagaaatac      660

atggcgctgg taagctggct ggtggaacat ggcatcactt ccgagaagca gtggattcag      720

gagaatcagg agagctacct gtccttcaac tccacgggaa actctcggag ccagattaaa      780

gccgcgcttg acaacgcgtc aaaaattatg agtctgacca aatctgcctc agactatctc      840

gtgggacaga ctgttccaga ggacatttct gaaaacagaa tctggcagat ttttgatctc      900

aacggctacg acccggcata cgcgggctct gttctctacg gctggtgcac tcgcgccttt      960

ggaaagagga acaccgtctg gctgtatgga cccgcgacca ccggaaagac caacatcgcg     1020

gaagccatct ctcacaccgt gcccttttat ggctgtgtga actggactaa tgagaacttt     1080

ccctttaatg actgtgtgga aaaaatgttg atctggtggg aggagggaaa gatgaccagc     1140

aaggtggtgg aacccgccaa ggccatcttg ggggggtcta gagtacgagt ggatcaaaaa     1200

tgtaaatcct ctgtacaagt agactctacc ccggtgatta tcacctccaa tactaacatg     1260

tgtgtggtgg tggatgggaa ctccacgacc tttgaacacc agcagccgct ggaagaccgc     1320

atgttcagat ttgaactcat gcggcggctc ccgccagatt ttggcaagat taccaagcag     1380

gaagtcaaag acttttttgc ttgggcaaag gtcaaccagg tgccggtgac tcacgagttt     1440

atggttccca agaaagtggc gggaactgag agggcggaga cttctagaaa acgcccactg     1500

gatgacgtca ccaataccaa ctataaaagt ccggagaagc gggcccggct ctcagttgtt     1560

cctgagacgc ctcgcagttc agacgtgcct gtagagcccg ctcctctgcg acctctcaac     1620

tggtcttcca ggtatgaatg cagatgtgac tatcatgcta aatttgactc tgtaacgggg     1680

gaatgtgacg agtgtgaata tttgaatcgg ggcaaaaatg gctgtatctt tcataatgct     1740

acacattgtc aaatttgtca cgctgttcct ccatgggaaa aggaaaatgt gtcagatttt     1800

aatgattttg atgactgtaa taaagagcag taa                                  1833


<210> 5297
<211> 2211
<212> DNA
<213> Bovine adeno-associated virus

<400> 5297
atgtcttttg ttgaccaccc tccagattgg ttggaatcga tcggcgacgg ctttcgtgaa       60

tttctcggcc ttgaggcggg tcccccgaaa cccaaggcca atcaacagaa gcaagataac      120

gctcgaggtc ttgtgcttcc tgggtacaag tatcttggtc ctgggaacgg ccttgataag      180

ggcgatcctg tcaattttgc tgacgaggtt gcccgagagc acgacctctc ctaccagaaa      240

cagcttgagg cgggcgataa cccttacctc aagtacaacc acgcggacgc agagtttcag      300

gagaaactcg cttctgacac ttcttttggg ggaaaccttg ggaaggctgt tttccaggct      360

aaaaagagga ttctcgaacc tcttggcctg gttgagacgc cggataaaac ggcgcctgcg      420

gcaaaaaaga ggcctctaga gcagagtcct caagagccag actcctcgag cggagttggc      480

aagaaaggca aacagcctgc cagaaagaga ctcaactttg acgacgaacc tggagccgga      540

gacgggcctc ccccagaagg accatcttcc ggagctatgt ctactgagac tgaaatgcgt      600

gcagcagctg gcggaaatgg tggcgatgcg ggacaaggtg ccgagggagt gggtaatgcc      660

tccggtgatt ggcattgcga ttccacttgg tcagagagcc acgtcaccac cacctcaacc      720

cgcacctggg tcctgccgac ctacaacaac cacctgtacc tgcggctcgg ctcgagcaac      780

gccagcgaca ccttcaacgg attctccacc ccctggggat actttgactt taaccgcttc      840

cactgccact tctcgccaag agactggcaa aggctcatca acaaccactg gggactgcgc      900

cccaaaagca tgcaagtccg catcttcaac atccaagtta aggaggtcac gacgtctaac      960

ggggagacga ccgtatccaa caacctcacc agcacggtcc agatctttgc ggacagcacg     1020

tacgagctcc cgtacgtgat ggatgcaggt caggagggca gcttgcctcc tttccccaac     1080

gacgtgttca tggtgcctca gtacgggtac tgcggactgg taaccggagg cagctctcaa     1140

aaccagacag acagaaatgc cttctactgt ctggagtact ttcccagcca gatgctgaga     1200

accggaaaca actttgagat ggtgtacaag tttgaaaacg tgcccttcca ctccatgtac     1260

gctcacagcc agagcctgga taggctgatg aacccgctgc tggaccagta cctgtgggag     1320

ctccagtcta ccacctctgg aggaactctc aaccagggca attcagccac caactttgcc     1380

aagctgacca aaacaaactt ttctggctac cgcaaaaact ggctcccggg gcccatgatg     1440

aagcagcaga gattctccaa gactgccagt caaaactaca agattcccca gggaagaaac     1500

aacagtctgc tccattatga gaccagaact accctcgacg gaagatggag caattttgcc     1560

ccgggaacgg ccatggcaac cgcagccaac gacgccaccg acttctctca ggcccagctc     1620

atctttgcgg ggcccaacat caccggcaac accaccacag atgccaataa cctgatgttc     1680

acttcagaag atgaacttag ggccaccaac ccccgggaca ctgacctgtt tggccacctg     1740

gcaaccaacc agcaaaacgc caccaccgtt cctaccgtag acgacgtgga cggagtcggc     1800

gtgtacccgg gaatggtgtg gcaggacaga gacatttact accaagggcc catttgggcc     1860

aaaattccac acacggatgg acactttcac ccgtctcctc tcattggcgg atttggactg     1920

aaaagcccgc ctccacaaat attcatcaaa aacactcctg tacccgccaa tcccgcaacg     1980

accttctctc cggccagaat caacagcttc atcacccagt acagcaccgg acaggtggct     2040

gtcaaaatag aatgggaaat ccagaaggag cggtccaaga gatggaaccc agaggtccag     2100

ttcacgtcca actacggagc acaggactcg cttctctggg ctcccgacaa cgccggagcc     2160

tacaaagagc ccagggccat tggatcccga tacctcacca accacctcta g              2211


<210> 5298
<211> 4694
<212> DNA
<213> Bovine adeno-associated virus

<400> 5298
gtggcactcc cccccctgtc gcgttcgctc gttcgctggc tcgattgggg gggtggcagc       60

tcaaagagct gccagacgac ggccctctgg gccgtcgccc ccccaatcga gccagcgaac      120

gagcgaacgc gacagggggg ggagtgccac actctctagc aagggggttt tgtaggtggt      180

gatgtcattg ttgatgtcat tatagttgtc acgcgatagt taatgattaa cagtcatgtg      240

atgtgtgtta tccaatagga tgaaagcgcg cgaatgagat ctcgcgagac ttccggggta      300

taaaaggggt gagtgaacga gcccgccgcc attctctgct ctggactgct agaggaccct      360

cgctgccatg gctaccttct atgaagtcat tgttcgcgtt ccatttgatg tggaagagca      420

cctgcctgga atttctgaca actttgtaga ctgggtaact ggtcaaattt gggagctgcc      480

tcccgagtca gatttgaatt tgactctgat tgagcagcct cagctgacgg tggctgacag      540

aattcgccgc gtgttcctgt acgagtggaa caaattttcc aagcaggaga gcaaattctt      600

tgtgcagttt gaaaagggat ctgaatattt tcatctgcac acgctcgtgg agacctccgg      660

catctcttct atggtccttg gccgctacgt gagtcagatt cgcgcccagc tggtgaaggt      720

ggtgttccag aacattgagc cgcggattaa cgactgggtc gccatcacca aggtaaagaa      780

gggcggagcc aataaggtgg tggattctgg gtatattccc gcctacctgc tgccgaaggt      840

ccaaccagag cttcagtggg cgtggactaa cctcgaagag tataaattgg ccgccctcaa      900

tctggaggag cgcaaacggc tcgtcgctca gtttcagctt gagtcctcgc agcgctcgca      960

agaggcatct tcccagaggg acgtttcggc tgacccggtc atcaagagca agacttccca     1020

gaaatacatg gcgctggtaa gctggctggt ggaacatggc atcacttccg agaagcagtg     1080

gattcaggag aatcaggaga gctacctgtc cttcaactcc acgggaaact ctcggagcca     1140

gattaaagcc gcgcttgaca acgcgtcaaa aattatgagt ctgaccaaat ctgcctcaga     1200

ctatctcgtg ggacagactg ttccagagga catttctgaa aacagaatct ggcagatttt     1260

tgatctcaac ggctacgacc cggcatacgc gggctctgtt ctctacggct ggtgcactcg     1320

cgcctttgga aagaggaaca ccgtctggct gtatggaccc gcgaccaccg gaaagaccaa     1380

catcgcggaa gccatctctc acaccgtgcc cttttatggc tgtgtgaact ggactaatga     1440

gaactttccc tttaatgact gtgtggaaaa aatgttgatc tggtgggagg agggaaagat     1500

gaccagcaag gtggtggaac ccgccaaggc catcttgggg gggtctagag tacgagtgga     1560

tcaaaaatgt aaatcctctg tacaagtaga ctctaccccg gtgattatca cctccaatac     1620

taacatgtgt gtggtggtgg atgggaactc cacgaccttt gaacaccagc agccgctgga     1680

agaccgcatg ttcagatttg aactcatgcg gcggctcccg ccagattttg gcaagattac     1740

caagcaggaa gtcaaagact tttttgcttg ggcaaaggtc aaccaggtgc cggtgactca     1800

cgagtttatg gttcccaaga aagtggcggg aactgagagg gcggagactt ctagaaaacg     1860

cccactggat gacgtcacca ataccaacta taaaagtccg gagaagcggg cccggctctc     1920

agttgttcct gagacgcctc gcagttcaga cgtgcctgta gagcccgctc ctctgcgacc     1980

tctcaactgg tcttccaggt atgaatgcag atgtgactat catgctaaat ttgactctgt     2040

aacgggggaa tgtgacgagt gtgaatattt gaatcggggc aaaaatggct gtatctttca     2100

taatgctaca cattgtcaaa tttgtcacgc tgttcctcca tgggaaaagg aaaatgtgtc     2160

agattttaat gattttgatg actgtaataa agagcagtaa ataaagtgag tagtcatgtc     2220

ttttgttgac caccctccag attggttgga atcgatcggc gacggctttc gtgaatttct     2280

cggccttgag gcgggtcccc cgaaacccaa ggccaatcaa cagaagcaag ataacgctcg     2340

aggtcttgtg cttcctgggt acaagtatct tggtcctggg aacggccttg ataagggcga     2400

tcctgtcaat tttgctgacg aggttgcccg agagcacgac ctctcctacc agaaacagct     2460

tgaggcgggc gataaccctt acctcaagta caaccacgcg gacgcagagt ttcaggagaa     2520

actcgcttct gacacttctt ttgggggaaa ccttgggaag gctgttttcc aggctaaaaa     2580

gaggattctc gaacctcttg gcctggttga gacgccggat aaaacggcgc ctgcggcaaa     2640

aaagaggcct ctagagcaga gtcctcaaga gccagactcc tcgagcggag ttggcaagaa     2700

aggcaaacag cctgccagaa agagactcaa ctttgacgac gaacctggag ccggagacgg     2760

gcctccccca gaaggaccat cttccggagc tatgtctact gagactgaaa tgcgtgcagc     2820

agctggcgga aatggtggcg atgcgggaca aggtgccgag ggagtgggta atgcctccgg     2880

tgattggcat tgcgattcca cttggtcaga gagccacgtc accaccacct caacccgcac     2940

ctgggtcctg ccgacctaca acaaccacct gtacctgcgg ctcggctcga gcaacgccag     3000

cgacaccttc aacggattct ccaccccctg gggatacttt gactttaacc gcttccactg     3060

ccacttctcg ccaagagact ggcaaaggct catcaacaac cactggggac tgcgccccaa     3120

aagcatgcaa gtccgcatct tcaacatcca agttaaggag gtcacgacgt ctaacgggga     3180

gacgaccgta tccaacaacc tcaccagcac ggtccagatc tttgcggaca gcacgtacga     3240

gctcccgtac gtgatggatg caggtcagga gggcagcttg cctcctttcc ccaacgacgt     3300

gttcatggtg cctcagtacg ggtactgcgg actggtaacc ggaggcagct ctcaaaacca     3360

gacagacaga aatgccttct actgtctgga gtactttccc agccagatgc tgagaaccgg     3420

aaacaacttt gagatggtgt acaagtttga aaacgtgccc ttccactcca tgtacgctca     3480

cagccagagc ctggataggc tgatgaaccc gctgctggac cagtacctgt gggagctcca     3540

gtctaccacc tctggaggaa ctctcaacca gggcaattca gccaccaact ttgccaagct     3600

gaccaaaaca aacttttctg gctaccgcaa aaactggctc ccggggccca tgatgaagca     3660

gcagagattc tccaagactg ccagtcaaaa ctacaagatt ccccagggaa gaaacaacag     3720

tctgctccat tatgagacca gaactaccct cgacggaaga tggagcaatt ttgccccggg     3780

aacggccatg gcaaccgcag ccaacgacgc caccgacttc tctcaggccc agctcatctt     3840

tgcggggccc aacatcaccg gcaacaccac cacagatgcc aataacctga tgttcacttc     3900

agaagatgaa cttagggcca ccaacccccg ggacactgac ctgtttggcc acctggcaac     3960

caaccagcaa aacgccacca ccgttcctac cgtagacgac gtggacggag tcggcgtgta     4020

cccgggaatg gtgtggcagg acagagacat ttactaccaa gggcccattt gggccaaaat     4080

tccacacacg gatggacact ttcacccgtc tcctctcatt ggcggatttg gactgaaaag     4140

cccgcctcca caaatattca tcaaaaacac tcctgtaccc gccaatcccg caacgacctt     4200

ctctccggcc agaatcaaca gcttcatcac ccagtacagc accggacagg tggctgtcaa     4260

aatagaatgg gaaatccaga aggagcggtc caagagatgg aacccagagg tccagttcac     4320

gtccaactac ggagcacagg actcgcttct ctgggctccc gacaacgccg gagcctacaa     4380

agagcccagg gccattggat cccgatacct caccaaccac ctctagccca attctgttgc     4440

ataccctcaa taaaccgtgt attcgtttca gtaaaatact gcctcttgtg gtcattcggc     4500

gtacaacagc ttacaacaac aacaaaaccc ccttgctaga gagtgtggca ctcccccccc     4560

tgtcgcgttc gctcgttcgc tggctcgatt gggggggtgg cagctcaaag agctgccaga     4620

cgacggccct ctgggccgtc gcccccccaa tcgagccagc gaacgagcga acgcgacagg     4680

ggggggagtg ccac                                                       4694


<210> 5299
<211> 390
<212> PRT
<213> Bovine adeno-associated virus

<400> 5299
Met Ala Leu Val Ser Trp Leu Val Glu His Gly Ile Thr Ser Glu Lys 
1               5                   10                  15      


Gln Trp Ile Gln Glu Asn Gln Glu Ser Tyr Leu Ser Phe Asn Ser Thr 
            20                  25                  30          


Gly Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
        35                  40                  45              


Ile Met Ser Leu Thr Lys Ser Ala Ser Asp Tyr Leu Val Gly Gln Thr 
    50                  55                  60                  


Val Pro Glu Asp Ile Ser Glu Asn Arg Ile Trp Gln Ile Phe Asp Leu 
65                  70                  75                  80  


Asn Gly Tyr Asp Pro Ala Tyr Ala Gly Ser Val Leu Tyr Gly Trp Cys 
                85                  90                  95      


Thr Arg Ala Phe Gly Lys Arg Asn Thr Val Trp Leu Tyr Gly Pro Ala 
            100                 105                 110         


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ser His Thr Val Pro 
        115                 120                 125             


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
    130                 135                 140                 


Cys Val Glu Lys Met Leu Ile Trp Trp Glu Glu Gly Lys Met Thr Ser 
145                 150                 155                 160 


Lys Val Val Glu Pro Ala Lys Ala Ile Leu Gly Gly Ser Arg Val Arg 
                165                 170                 175     


Val Asp Gln Lys Cys Lys Ser Ser Val Gln Val Asp Ser Thr Pro Val 
            180                 185                 190         


Ile Ile Thr Ser Asn Thr Asn Met Cys Val Val Val Asp Gly Asn Ser 
        195                 200                 205             


Thr Thr Phe Glu His Gln Gln Pro Leu Glu Asp Arg Met Phe Arg Phe 
    210                 215                 220                 


Glu Leu Met Arg Arg Leu Pro Pro Asp Phe Gly Lys Ile Thr Lys Gln 
225                 230                 235                 240 


Glu Val Lys Asp Phe Phe Ala Trp Ala Lys Val Asn Gln Val Pro Val 
                245                 250                 255     


Thr His Glu Phe Met Val Pro Lys Lys Val Ala Gly Thr Glu Arg Ala 
            260                 265                 270         


Glu Thr Ser Arg Lys Arg Pro Leu Asp Asp Val Thr Asn Thr Asn Tyr 
        275                 280                 285             


Lys Ser Pro Glu Lys Arg Ala Arg Leu Ser Val Val Pro Glu Thr Pro 
    290                 295                 300                 


Arg Ser Ser Asp Val Pro Val Glu Pro Ala Pro Leu Arg Pro Leu Asn 
305                 310                 315                 320 


Trp Ser Ser Arg Tyr Glu Cys Arg Cys Asp Tyr His Ala Lys Phe Asp 
                325                 330                 335     


Ser Val Thr Gly Glu Cys Asp Glu Cys Glu Tyr Leu Asn Arg Gly Lys 
            340                 345                 350         


Asn Gly Cys Ile Phe His Asn Ala Thr His Cys Gln Ile Cys His Ala 
        355                 360                 365             


Val Pro Pro Trp Glu Lys Glu Asn Val Ser Asp Phe Asn Asp Phe Asp 
    370                 375                 380                 


Asp Cys Asn Lys Glu Gln 
385                 390 


<210> 5300
<211> 610
<212> PRT
<213> Bovine adeno-associated virus

<400> 5300
Met Ala Thr Phe Tyr Glu Val Ile Val Arg Val Pro Phe Asp Val Glu 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Asn Phe Val Asp Trp Val Thr Gly 
            20                  25                  30          


Gln Ile Trp Glu Leu Pro Pro Glu Ser Asp Leu Asn Leu Thr Leu Ile 
        35                  40                  45              


Glu Gln Pro Gln Leu Thr Val Ala Asp Arg Ile Arg Arg Val Phe Leu 
    50                  55                  60                  


Tyr Glu Trp Asn Lys Phe Ser Lys Gln Glu Ser Lys Phe Phe Val Gln 
65                  70                  75                  80  


Phe Glu Lys Gly Ser Glu Tyr Phe His Leu His Thr Leu Val Glu Thr 
                85                  90                  95      


Ser Gly Ile Ser Ser Met Val Leu Gly Arg Tyr Val Ser Gln Ile Arg 
            100                 105                 110         


Ala Gln Leu Val Lys Val Val Phe Gln Asn Ile Glu Pro Arg Ile Asn 
        115                 120                 125             


Asp Trp Val Ala Ile Thr Lys Val Lys Lys Gly Gly Ala Asn Lys Val 
    130                 135                 140                 


Val Asp Ser Gly Tyr Ile Pro Ala Tyr Leu Leu Pro Lys Val Gln Pro 
145                 150                 155                 160 


Glu Leu Gln Trp Ala Trp Thr Asn Leu Glu Glu Tyr Lys Leu Ala Ala 
                165                 170                 175     


Leu Asn Leu Glu Glu Arg Lys Arg Leu Val Ala Gln Phe Gln Leu Glu 
            180                 185                 190         


Ser Ser Gln Arg Ser Gln Glu Ala Ser Ser Gln Arg Asp Val Ser Ala 
        195                 200                 205             


Asp Pro Val Ile Lys Ser Lys Thr Ser Gln Lys Tyr Met Ala Leu Val 
    210                 215                 220                 


Ser Trp Leu Val Glu His Gly Ile Thr Ser Glu Lys Gln Trp Ile Gln 
225                 230                 235                 240 


Glu Asn Gln Glu Ser Tyr Leu Ser Phe Asn Ser Thr Gly Asn Ser Arg 
                245                 250                 255     


Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys Ile Met Ser Leu 
            260                 265                 270         


Thr Lys Ser Ala Ser Asp Tyr Leu Val Gly Gln Thr Val Pro Glu Asp 
        275                 280                 285             


Ile Ser Glu Asn Arg Ile Trp Gln Ile Phe Asp Leu Asn Gly Tyr Asp 
    290                 295                 300                 


Pro Ala Tyr Ala Gly Ser Val Leu Tyr Gly Trp Cys Thr Arg Ala Phe 
305                 310                 315                 320 


Gly Lys Arg Asn Thr Val Trp Leu Tyr Gly Pro Ala Thr Thr Gly Lys 
                325                 330                 335     


Thr Asn Ile Ala Glu Ala Ile Ser His Thr Val Pro Phe Tyr Gly Cys 
            340                 345                 350         


Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp Cys Val Glu Lys 
        355                 360                 365             


Met Leu Ile Trp Trp Glu Glu Gly Lys Met Thr Ser Lys Val Val Glu 
    370                 375                 380                 


Pro Ala Lys Ala Ile Leu Gly Gly Ser Arg Val Arg Val Asp Gln Lys 
385                 390                 395                 400 


Cys Lys Ser Ser Val Gln Val Asp Ser Thr Pro Val Ile Ile Thr Ser 
                405                 410                 415     


Asn Thr Asn Met Cys Val Val Val Asp Gly Asn Ser Thr Thr Phe Glu 
            420                 425                 430         


His Gln Gln Pro Leu Glu Asp Arg Met Phe Arg Phe Glu Leu Met Arg 
        435                 440                 445             


Arg Leu Pro Pro Asp Phe Gly Lys Ile Thr Lys Gln Glu Val Lys Asp 
    450                 455                 460                 


Phe Phe Ala Trp Ala Lys Val Asn Gln Val Pro Val Thr His Glu Phe 
465                 470                 475                 480 


Met Val Pro Lys Lys Val Ala Gly Thr Glu Arg Ala Glu Thr Ser Arg 
                485                 490                 495     


Lys Arg Pro Leu Asp Asp Val Thr Asn Thr Asn Tyr Lys Ser Pro Glu 
            500                 505                 510         


Lys Arg Ala Arg Leu Ser Val Val Pro Glu Thr Pro Arg Ser Ser Asp 
        515                 520                 525             


Val Pro Val Glu Pro Ala Pro Leu Arg Pro Leu Asn Trp Ser Ser Arg 
    530                 535                 540                 


Tyr Glu Cys Arg Cys Asp Tyr His Ala Lys Phe Asp Ser Val Thr Gly 
545                 550                 555                 560 


Glu Cys Asp Glu Cys Glu Tyr Leu Asn Arg Gly Lys Asn Gly Cys Ile 
                565                 570                 575     


Phe His Asn Ala Thr His Cys Gln Ile Cys His Ala Val Pro Pro Trp 
            580                 585                 590         


Glu Lys Glu Asn Val Ser Asp Phe Asn Asp Phe Asp Asp Cys Asn Lys 
        595                 600                 605             


Glu Gln 
    610 


<210> 5301
<211> 736
<212> PRT
<213> Bovine adeno-associated virus

<400> 5301
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Ser Ile Gly Asp 
1               5                   10                  15      


Gly Phe Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Asp Pro Val 
    50                  55                  60                  


Asn Phe Ala Asp Glu Val Ala Arg Glu His Asp Leu Ser Tyr Gln Lys 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Ser Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Thr Pro Asp Lys Thr Ala Pro Ala Ala Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Lys Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Asp Asp Glu 
                165                 170                 175     


Pro Gly Ala Gly Asp Gly Pro Pro Pro Glu Gly Pro Ser Ser Gly Ala 
            180                 185                 190         


Met Ser Thr Glu Thr Glu Met Arg Ala Ala Ala Gly Gly Asn Gly Gly 
        195                 200                 205             


Asp Ala Gly Gln Gly Ala Glu Gly Val Gly Asn Ala Ser Gly Asp Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Ser Glu Ser His Val Thr Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu 
                245                 250                 255     


Gly Ser Ser Asn Ala Ser Asp Thr Phe Asn Gly Phe Ser Thr Pro Trp 
            260                 265                 270         


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
        275                 280                 285             


Trp Gln Arg Leu Ile Asn Asn His Trp Gly Leu Arg Pro Lys Ser Met 
    290                 295                 300                 


Gln Val Arg Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn 
305                 310                 315                 320 


Gly Glu Thr Thr Val Ser Asn Asn Leu Thr Ser Thr Val Gln Ile Phe 
                325                 330                 335     


Ala Asp Ser Thr Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu 
            340                 345                 350         


Gly Ser Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr 
        355                 360                 365             


Gly Tyr Cys Gly Leu Val Thr Gly Gly Ser Ser Gln Asn Gln Thr Asp 
    370                 375                 380                 


Arg Asn Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Met Val Tyr Lys Phe Glu Asn Val Pro Phe 
                405                 410                 415     


His Ser Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Leu Asp Gln Tyr Leu Trp Glu Leu Gln Ser Thr Thr Ser Gly Gly 
        435                 440                 445             


Thr Leu Asn Gln Gly Asn Ser Ala Thr Asn Phe Ala Lys Leu Thr Lys 
    450                 455                 460                 


Thr Asn Phe Ser Gly Tyr Arg Lys Asn Trp Leu Pro Gly Pro Met Met 
465                 470                 475                 480 


Lys Gln Gln Arg Phe Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro 
                485                 490                 495     


Gln Gly Arg Asn Asn Ser Leu Leu His Tyr Glu Thr Arg Thr Thr Leu 
            500                 505                 510         


Asp Gly Arg Trp Ser Asn Phe Ala Pro Gly Thr Ala Met Ala Thr Ala 
        515                 520                 525             


Ala Asn Asp Ala Thr Asp Phe Ser Gln Ala Gln Leu Ile Phe Ala Gly 
    530                 535                 540                 


Pro Asn Ile Thr Gly Asn Thr Thr Thr Asp Ala Asn Asn Leu Met Phe 
545                 550                 555                 560 


Thr Ser Glu Asp Glu Leu Arg Ala Thr Asn Pro Arg Asp Thr Asp Leu 
                565                 570                 575     


Phe Gly His Leu Ala Thr Asn Gln Gln Asn Ala Thr Thr Val Pro Thr 
            580                 585                 590         


Val Asp Asp Val Asp Gly Val Gly Val Tyr Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Ser Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Ala Thr Thr Phe Ser Pro Ala Arg Ile Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ala Val Lys Ile Glu Trp Glu Ile Gln 
        675                 680                 685             


Lys Glu Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn 
    690                 695                 700                 


Tyr Gly Ala Gln Asp Ser Leu Leu Trp Ala Pro Asp Asn Ala Gly Ala 
705                 710                 715                 720 


Tyr Lys Glu Pro Arg Ala Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730                 735     


<210> 5302
<211> 600
<212> PRT
<213> Bovine adeno-associated virus

<400> 5302
Thr Ala Pro Ala Ala Lys Lys Arg Pro Leu Glu Gln Ser Pro Gln Glu 
1               5                   10                  15      


Pro Asp Ser Ser Ser Gly Val Gly Lys Lys Gly Lys Gln Pro Ala Arg 
            20                  25                  30          


Lys Arg Leu Asn Phe Asp Asp Glu Pro Gly Ala Gly Asp Gly Pro Pro 
        35                  40                  45              


Pro Glu Gly Pro Ser Ser Gly Ala Met Ser Thr Glu Thr Glu Met Arg 
    50                  55                  60                  


Ala Ala Ala Gly Gly Asn Gly Gly Asp Ala Gly Gln Gly Ala Glu Gly 
65                  70                  75                  80  


Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp Ser Glu 
                85                  90                  95      


Ser His Val Thr Thr Thr Ser Thr Arg Thr Trp Val Leu Pro Thr Tyr 
            100                 105                 110         


Asn Asn His Leu Tyr Leu Arg Leu Gly Ser Ser Asn Ala Ser Asp Thr 
        115                 120                 125             


Phe Asn Gly Phe Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
    130                 135                 140                 


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn His 
145                 150                 155                 160 


Trp Gly Leu Arg Pro Lys Ser Met Gln Val Arg Ile Phe Asn Ile Gln 
                165                 170                 175     


Val Lys Glu Val Thr Thr Ser Asn Gly Glu Thr Thr Val Ser Asn Asn 
            180                 185                 190         


Leu Thr Ser Thr Val Gln Ile Phe Ala Asp Ser Thr Tyr Glu Leu Pro 
        195                 200                 205             


Tyr Val Met Asp Ala Gly Gln Glu Gly Ser Leu Pro Pro Phe Pro Asn 
    210                 215                 220                 


Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Cys Gly Leu Val Thr Gly 
225                 230                 235                 240 


Gly Ser Ser Gln Asn Gln Thr Asp Arg Asn Ala Phe Tyr Cys Leu Glu 
                245                 250                 255     


Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Met Val 
            260                 265                 270         


Tyr Lys Phe Glu Asn Val Pro Phe His Ser Met Tyr Ala His Ser Gln 
        275                 280                 285             


Ser Leu Asp Arg Leu Met Asn Pro Leu Leu Asp Gln Tyr Leu Trp Glu 
    290                 295                 300                 


Leu Gln Ser Thr Thr Ser Gly Gly Thr Leu Asn Gln Gly Asn Ser Ala 
305                 310                 315                 320 


Thr Asn Phe Ala Lys Leu Thr Lys Thr Asn Phe Ser Gly Tyr Arg Lys 
                325                 330                 335     


Asn Trp Leu Pro Gly Pro Met Met Lys Gln Gln Arg Phe Ser Lys Thr 
            340                 345                 350         


Ala Ser Gln Asn Tyr Lys Ile Pro Gln Gly Arg Asn Asn Ser Leu Leu 
        355                 360                 365             


His Tyr Glu Thr Arg Thr Thr Leu Asp Gly Arg Trp Ser Asn Phe Ala 
    370                 375                 380                 


Pro Gly Thr Ala Met Ala Thr Ala Ala Asn Asp Ala Thr Asp Phe Ser 
385                 390                 395                 400 


Gln Ala Gln Leu Ile Phe Ala Gly Pro Asn Ile Thr Gly Asn Thr Thr 
                405                 410                 415     


Thr Asp Ala Asn Asn Leu Met Phe Thr Ser Glu Asp Glu Leu Arg Ala 
            420                 425                 430         


Thr Asn Pro Arg Asp Thr Asp Leu Phe Gly His Leu Ala Thr Asn Gln 
        435                 440                 445             


Gln Asn Ala Thr Thr Val Pro Thr Val Asp Asp Val Asp Gly Val Gly 
    450                 455                 460                 


Val Tyr Pro Gly Met Val Trp Gln Asp Arg Asp Ile Tyr Tyr Gln Gly 
465                 470                 475                 480 


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser 
                485                 490                 495     


Pro Leu Ile Gly Gly Phe Gly Leu Lys Ser Pro Pro Pro Gln Ile Phe 
            500                 505                 510         


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ala Thr Thr Phe Ser Pro 
        515                 520                 525             


Ala Arg Ile Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ala 
    530                 535                 540                 


Val Lys Ile Glu Trp Glu Ile Gln Lys Glu Arg Ser Lys Arg Trp Asn 
545                 550                 555                 560 


Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly Ala Gln Asp Ser Leu Leu 
                565                 570                 575     


Trp Ala Pro Asp Asn Ala Gly Ala Tyr Lys Glu Pro Arg Ala Ile Gly 
            580                 585                 590         


Ser Arg Tyr Leu Thr Asn His Leu 
        595                 600 


<210> 5303
<211> 97209
<212> DNA
<213> Homo sapiens

<400> 5303
atggaattcc ccattggatc cctcgaaact aacaacttcc gtcgctttac tccggagtca       60

ctggtggaga tagagaagca aattgctgcc aagcagggaa caaagaaagc cagagagaag      120

catagggagc agaaggacca agaagagaag cctcggcccc agctggactt gaaagcctgc      180

aaccagctgc ccaagttcta tggtgagctc ccagcagaac tgatcgggga gcccctggag      240

gatctagatc cgttctacag cacacaccgg gtaagagcta ctagtaggaa tgtctgctct      300

cagctcttgg agaggaagtc tcggtcccac ccagcccaga aagtcctcct tggccctggg      360

tgatgtggca gtctgctaaa gattccgtta acaaccaaaa aaaatatata tatatatctc      420

taacttattt gatgatctct ttgaattttt atgacattta tgatagaaac taactaaacc      480

cacatcttca aaagcagata actgctgcag agctttcagg gaaagttggc tgttcccttg      540

gatgacctct ggcctggggc ctccagagga gttgggtctc tttgcaggtg gagagcagac      600

atcttgaggt tgggggagga gcatggcggt gaggacagaa agcaggatga atttaagcca      660

gtggtcctca actatgatct tggaacccct ggtgtcccca aaactgtttt agtgggttta      720

taaaatgaaa actattgtat aacaatactt ggatgtaatt tgtctttttc acacactttc      780

tcttatgatc atacattggt gaatatagag gctattgatg ggggatgatg tcatcactct      840

aaaagctact ggaatgtgtg cctgtatatt cccgtgtttt aaaatttcct gagttttgaa      900

tttctaatat gagatatata tacacacaca tatgatgtat atatgtgtgt atacatctat      960

acactatata tatacataca actatgtata tacatacaac tagaccatgt agctagttat     1020

gtatatatag gtatataagc atatatacat atatattaat ttctaatatg atatacatat     1080

atctggcata aacaaaaagg tatcaacata aacaaaagtt atttggggtc ctcaataagg     1140

tttgagagta ataatccctg aaatcaaaaa gtttgagaat cagtagttta aacaagagct     1200

tcttcatgac aattatctca cctgtgttgt atttttgatg ttctacgagc caaaaaatgg     1260

tgaatgcatg tttgggagtt aggaggacag gaatcagcca tctcaaatat ggctagcaga     1320

gtaaataaaa aggcactgaa tatctttctt cctcctctcc catgccaaga gttcatatcc     1380

tcctaaatcc tcagagggag aaaccaggag aggatttaag agacagagat gtagaaggtg     1440

gagacagaag aaacattaca aaacaaggat ggttctcttg tcagaagaga aattaaatgc     1500

aaccataact tcaccatcct gttgccagag tcctcccctg ggcataacac ctcttaccag     1560

cctgaggatt ggctgtctgt ccattaaagt accctcagtg ggctcatctt ggtgcactgt     1620

cagtcccaga gatgaggatc ttgctgagag ggtgaggata tggcttttag tccttgatcc     1680

tctctgcctc tctgtacctg catttgactc tcattgacct gtagttccca gagcccttct     1740

tgctcataag cctgagataa tgcctctcat gtttaaaaac atggttgtat aaggaatctt     1800

gtttctcatt ggaggtccac tttctgtttt gttttgtttc agacatttat ggtgctgaac     1860

aaagggagga ccatttcccg gtttagtgcc actcgggccc tgtggctatt cagtcctttc     1920

aacctgatca gaagaacggc catcaaagtg tctgtccact catatccttt gcacgattgc     1980

ctcttccacg tgttacaatt agaccttgcc tactgtgtcc agtaccttct ttagaggtta     2040

gcaacagagc ccttatccaa ttgaatccca aaagtacaat gaggtcatta gattgaaaaa     2100

atggcttggg cctttaatgt gtcccacacc ccaaagcagt cccaagacac agaagaagtg     2160

tttatgcaac acacaggtgg tttggattca cctcagacta atctagacac acctgtggat     2220

gcacaacttg aaaaacatcc tctttatgag gggaggtttg ctgatgcccc cagacacatt     2280

ctcaccacgg tgtgtggtcc gctttcccca caacacaaca ggcagtaaga gggcccaagc     2340

cttctttggg cagatgagat aggcatgagt tgttgctctg tgccatagcc atgctgagaa     2400

gtggctgctt actgggcaaa agagcagcac ctcccagagg gcaaggaaaa cagaccatga     2460

tgggaagagc acacatagtc tcaatgggac ctcattggtc atggggcact gttaacatca     2520

caaattactc aaaaactact agcaggttta aaatgtcaat aatctgatgt tcatgccata     2580

caagactgta atgattagag acacattggt caaatgtcta ctatatgaat tgttttaggt     2640

aatgtcagaa gctgctttca ggggattttg caaggcaagc caaactagta gaaaaaagat     2700

actttggttt ggtttcctaa gatcttcctg ggtgatccta atggaaagat cctaatgacc     2760

taagatcctt ggtcatcgga aggattggaa gttctttatg acaaatttag ccctggcttg     2820

caggaggttg atgtacaaga atacacctgc ctcagttgcc tgacaaatgg taaccagcct     2880

tttcttagaa ggcttcagta aaaaagagtt ctaccctgct ccctaactct gaggcagatt     2940

gttggatttc tggacagttg tcattgagct ggtaaccttg gcacagtcat ctatctgcac     3000

actcaacatg aagctgcaca gcttgatgaa gttgcattac gttttctctt tttacatttt     3060

tttctttctg gctggccagc aagaattacg ttttctgagc tgaatcttga attttcagat     3120

tctacagaag gatatttaat gacaatacag tctctcactt gctaaatact tcctaagtgt     3180

caataccatc atcagttcaa aagcctctga agtagagatt accatcccca ttttacagat     3240

aatgaaactg acacacagag gcattaagta aattatccaa gaccatgtag ctagttaaga     3300

agtccagcct gcatcctgcg tagagcagta tctacagtga ggaagtaggg tggaaagtaa     3360

tcagggtaat tattctctca atgtgtcgtc tctgcttggg tagttgttgc tttttcaaaa     3420

tatatacaat tacatggaaa ttacaaataa agagaaatca caaacataca aactcctctt     3480

tatggattct ggttgaatta catctggata agtaagaaac agctaattag aaataaaatc     3540

ccctaaaaag aaccaagtga ccagtgaata ttctcttcat cttgagattt gatgagtaaa     3600

taattgcttg gtagagtcac agctggacag aaaagctgtt gagggggtct cttcctcaca     3660

aaagtctgca tttaaatctc ataaatttgg taactccagc cccaaaagat actagaattc     3720

tcagggccct attattaata tttcaccaaa aatataattc taatcacatt tgctatgaat     3780

gttttcataa ctaatattat acataagata tattactttt aaatatttgt agaattggag     3840

acacgatttt agtttaatcc ttggattaac atttcccccc atgtgagcat atttcttaat     3900

ttaattgtaa gtcagcagga aaatgtggtt taattaatag aattttcctt ttcataatag     3960

atgtgttcct aagtaactgt aaaactagac acatcaaggc atttacagaa aactaaaata     4020

catttaaata cttctgctca aattgaaaaa tgagtgttgt actctctctg taggtcaagt     4080

ttatcttcaa gttttatttt tccttaggaa gcactgttgg gagcccagct attcctaaga     4140

aaaatgtcca agtgggaaca atttaccttt agattctccc caccaacatt tcttcccttc     4200

tattttcccc ttccacccac cttcctttca atgtctccct ccccttttga taatcccttt     4260

gcccatagtc tgctgtcaat attctccact ctagctattc agagttctcc actccagcct     4320

aatcctactt ggggttttct tcctgagcca gtatttcatt tccctgtgcc tgcctccacc     4380

gttcctaccc agaagaccat ttcctcggtg gaactgatct caactaagtt acccaaacaa     4440

tctgatgaaa ctaattccca tgaaagtttg tacctcttca cttatctcca agtttctaac     4500

ttttctttgt cttttagaat aaaaaagaca tttgccagat gaaatttcag gccattttgt     4560

atactgaaat gaaggcttcg gggcagaagg acattttgga aaagggagtc tgtttccttc     4620

tatcttgctc agagtttgtt atcaaacaga taagagttca catctctgca gcatggttga     4680

ctagctgcat gacctgagaa aagttattta acttttattt tttgtcagcc tgtttctcag     4740

cttcaaaatg tagatattta tacccacctg tagatcagtt gtattagaag taacatggac     4800

aaagtactca gcctagctta ggcactcagt aaatgttagt ggttattatg tgacaagatc     4860

ataaagctaa tattggctaa gatttatgaa tgtaatcatt cagcatcaag gtgatcctag     4920

atgacatcac agagacttgg tgatctcagc ttttccttaa cacaggcctt tcaggtggtt     4980

cagtttattt attacggtca ctattttggt taattgtgtg tgcatgaccc gaactgacct     5040

tccagagaaa attgagtgag tagatttgct atcattattg taccatctct ttttgctttc     5100

ttttcttcct tcacttggca gtctttgtct tttatttatc ctgccatgcc tcatgtgggt     5160

aatgctgaat ctcattgtct atatgtcttt gtaataacca ggtctctcct tctgtgagat     5220

ttgtttcata aacatacatg attttcagtt tcaaagagat acagattagt ggttctcaac     5280

tttggctgca tattgcaatt tttggggaga ttttttaaat gcctgagtcc cagccccaga     5340

aagtctaagg tggcctggga agatgagtct cctcgccccc accccccccc aacacacaca     5400

cactcactca cctgctagat gcacacacaa atgtatgcct tagagaaggt atgcttttga     5460

gaaggcctgc tatgaaagag agacaggagc aaaactgaga cagaactaag aacaaatggc     5520

tctggagtat atttagaaaa taactcataa atgaagctgt ttaagttatc atgcttcata     5580

tgcctcaaag taaccttagt attcctgaag ttattctatt tccctaggtt agtgggtgaa     5640

acccctatag tttcagaatc tgggagtttt ccaaaaacat tccatatcca cacatctggg     5700

agggatgctt ccactccagc ttgaacctaa catacctttg gttataataa caggtgcttt     5760

gcagagcttt cttttttttt tttttttttt ttttgctaat cataacagta atgcatgcca     5820

caacagaaaa tacgttatat ttttattaat agattaaagg aaaaggatca catagtcttc     5880

ttaattgatg ctaaaatcat ttgataaagt ttaatttcca tttataattt taaattctta     5940

gaaaagttga aatagaaggg aataaatgtg gcacatatac accatggaat gctatgcagt     6000

cataaaaaag gatgagttca tgtcctttgc agggacatgg atgaagctgg aaaccatcat     6060

tctcagcaaa ctaacacaag aacagaaaac caaacaccgt atgttctcac tcataagtgg     6120

gagttgaaca atgagaacac atggacacag ggaggggaac acactggggc ctgttgaggg     6180

gtggggggct aggggaggga tagcattagg agaaatacct aatgtaaatg acgggttgaa     6240

gggtgcagca aaccaccatg gcacgggtac acctatgtaa caaaccggca cgttctgcac     6300

atgtacccca gaacttaaag tataataatt ttaaaaaggg gattgcatca ctctgataaa     6360

gggtattcat tgttttaaag tatcaagcgt catacttaat tgtgaacatg gaaagctttc     6420

cctttgagat caaaagaaaa aaaaaccaaa gatgtctgtt cttctcagtt ccactttgta     6480

aaggaggtct cagccagcat agtaaagcaa agaaaaaaaa agtgcaagaa gaaaaaagta     6540

ccgaagatgt aatttacaga taataagatt gtatacataa aatatccaac ataacctaga     6600

gataaacagt aagaattaat aaaagagtat agtaaggtag ctgggtacaa attaacatac     6660

ataaatcaat tgtgtataga cactagcaac aaacagaaaa tagtttttaa aaataccatt     6720

tacactggca ttttaaaatg tcaagtatct aggaataaga ttatcaaagt ataagtgaga     6780

tctctataag gaaaattata ataagtattg tgtaaagttt ttaaagaaaa ccaaatcagt     6840

ggggagacat gttctcagat tcaaagtctc aatattgtaa agactcccaa aaatgattaa     6900

taaatttaat atgatcctca aatcaatatt tcaacaggct tcttttggta ttacttgaca     6960

aactttaaac tttaaatttt cttcctcaaa agtttacatg aaattttaaa gagcaaatta     7020

tagccaagaa acttttgagg aagaaataca aagtgggaga actcattcta ctggatgtcg     7080

agatttacta taaagctcta attgaagcag tgtgccattg gtgtaagatt ggtcagaata     7140

atgtaacagc atagacagtc cataaacaga ccaacacata tgtaaacatc taatgtgtga     7200

aaaggtggca ccccagaaca gcagggaaaa ggcggtcttc aaaaaatgat gctgaagaat     7260

taggaatctc actggaaaaa ctacattaaa catccaactt tgcaccacac acaagaatca     7320

attctaggtg gatcaacacc tcacttgctt tgtgaaatgc aaatatataa agcccttttt     7380

taaattttac tttaagttct ggggtacatg tgcagaaagt gcaggtttgt tacataggta     7440

tacacatgtc atggtggttt gctgcaccca tcaacccatc atctacatta ggtatttctc     7500

ctaatgctat ccctccccta gcccccaacc cctcaacagg ccctggtgtg tgatgtcccc     7560

ctccctgtat ccacgtgctc tcattgttca tctcccacct atgagtgaga acatgcggtg     7620

tttggttttc tgttcttatg tcagtttgct gagaatgatg gtttccagct tcatccatgt     7680

ccctgcaaag aacatgaact cacccttttt tatggctgca tagtattcca tggtgtatat     7740

gtgccatatt ttctttatcc agtctatcac tgatgggcgt ttgggttagt tccaagtctt     7800

tgctattgtc aatagtgcca caataaacat acgcatgctt gtatctttat agtagaataa     7860

tttataatcc tttgggtata tacccagtaa tggaattgct gggtcaaatg gtgtttctgg     7920

ttctagatcc ttgaggaatc accacactgt cttccacaat ggttgaacta atttacactc     7980

ccaccaacag tgtaaaagca ttcctatctc tccacatcct ctccagcatc tgttgtttcc     8040

tgacttttta atgatctcca ttctaactgg tatgagactc catctcattg tggttttgac     8100

tggcatttct ctaatgacca gtgatgatga gctttttatc atatgtttat tggctgcata     8160

aatgtcttct tttgagaagt gtctgttcat atcctttgcc cactttttga tggagttgtt     8220

ttttcttgta aatttgttta agttttttgt agattctgga tattagccct ttgtcagatt     8280

gatagattgc aaaaattttc tcccattctg taggttacct attcactctg atgatagttt     8340

cttttgctgt gcagaagctc tttagtttaa ttggattcca tttgtcaatt ttggcttttg     8400

tcaccattgc ttttgatgtg ttagtcataa agcctttgcc catgcctatg tcctgaaggg     8460

tattgcctag gttttcttct agggttttta tggttttagg tcttatgttt aagtctttaa     8520

tctatcttga gttaattttt gtgtaaggta taaggaaggg atctagtttc aattttctgc     8580

ctaaggctag ccagttttcc ccacaccatt tattaaatag ggaatccttt ccccattgct     8640

tgcttttgtc aagtttgtca aagatcagat ggttgtagat atgcggtgtt acttctgagg     8700

cctctgttct gttccattgg tctagatatc tgttttggta ccagtacctc gctgttttgg     8760

ttactgtagc tttgtagtat agcttgaagt caggtagcgt gatgcctcca actttcttct     8820

ttttgcttag aattgtcttg actatgcggg ctcttttttg ttccacatga aatttaaagt     8880

agatttttct aattctgtga agaaagtcag tggtagcttg atggggataa cattgaatct     8940

ataaattact ttgggcagta tggccatttt cacaatattg atttttccta tccatgagca     9000

tggaatgttt ttccatttat ttgtgtcctc tcttatttcc ttgagcagtg atttttagtt     9060

ctccttgaag aggtccttca catcccttgt aagttgtatt tctagatatt ttattctctt     9120

tgttgcaatt gtgaatggga gttcactcat gatttggctc tcggtttgtc tgttattggt     9180

gtatgggaat gcttgtgatt tttgcacatt gattttgtat cctgagactt tgctgaagtt     9240

gcttatcagc ttaaggagat tttgggctga gatgatgggg ttttctaaat atacagtcat     9300

gtcatctgca aacagagaca atttgacttc ctcttttcct atttgaatac cccttatttc     9360

tttctcttgc ctgatcgccc tggccagaac ttccaatact atgttgaata agagtggtga     9420

gatagggcat tcttgtcttg tgctggtttt caaaggaaat gcttccagtt tttgcccatt     9480

cagtatgata ttggctgggg gcttgtcata aatagttctt attattttga gatacattcc     9540

atcaatacct agtttattga gagcttttag catgaatggg tgttgaattt tgtcgaagac     9600

cttttctgca tctattgaga taatcacgtg gtttttgtca ttggttctgt ttgtgtgatg     9660

gattacgttt attgacttgc gtatgttgaa ccagctttga tcccaggtat gaagccgact     9720

tgatcgtggt ggataagctt tttgaaagga aaaaacaaag aggaatatct ttatgacctc     9780

agactaagaa aaactttatt acatatgaca caagaagcac taactataca ggaaaaaact     9840

gatacatttt agtatactat aattaagaat gttcatcaga agacaacttt aagagcatga     9900

aaaagcaagt gcttatattc agagtaatga actctacaaa tcaattagaa aaatgtcaga     9960

acaaccactt gtaaaatagc acaaaatttg aataggcact ttacaaaagt ggaaatccaa    10020

atggccataa acatatgaaa gtattcttaa ccttttttta aatcaaagag ttgcaaatta    10080

aaatcacact gagattttat tacatgttca tcatagaagg gaaatttttt aaagtgtcac    10140

aataccaagt attgggaatg acatggagca acagaaactc acacactgct ggtgggagtg    10200

taaatttgga caacctcttt ggaaagcaag gggtattatc tagtaaaggt gtaagcatac    10260

atatgctgta ttcttctatt acacccttag gtacctatgt ttaacagaaa tatgtacttg    10320

tggacaccag attacagcta caagaaagtt tatgaacatt tgcccataaa aaccccaaac    10380

cggaaaccac tcaaatgtcc ataaactttg agtacattaa ctatttctgt tatattctaa    10440

aatgagaaaa cttacagcaa taaaaattaa taaactttag tgctgcacaa caataaggat    10500

gagtcttaag aaagtaatat tgaacaaaaa aagccaaatg caaaggatta cataaacaag    10560

gttcatttat ataaagtttg aaatcaagca aaactaaact attttgttta ggaatgcata    10620

cttatgaagt aaaaagcatc aataaagtaa ggcaagaaaa agtaccaaaa attaggagaa    10680

tagtggcctc cagggcagaa gagggaggat gtaattggga aggagctggt gaagtgctgg    10740

tcacgttcca ttttatggca tgggtagttg tcacacaagc tgctatggag tgaattttgt    10800

cccctcaaaa ttcaaatgtt gaaacaaacc ccccatgttg ctatgttgga gattgggcct    10860

ctaaggaggt gattgggtta aatgaagtca caagagtaga gcccttaagt ggtagaactg    10920

gtgtccttat aagagaaaga gacagctttc tcccctttgt gtgagaacac aaggacaagg    10980

tagacatcta taagctagaa agagagtctt tcccagaccc aactatgctg acatcccaat    11040

ctcaggcttc aacctccaga tttgtgagaa aataaatttc tgttgcataa gccacccagt    11100

ctatggtatt ttgttaaggc aacaaaggct gactaataca caaacatttg ttttaaaata    11160

attaatttat gttttatgta catttttatt atgcatgtta catatcataa taaaaaccca    11220

ataatttttt aaaataaatg accattgcaa aaaatgcaga acactgaaaa tataaatcag    11280

aagatggtta ctaagtagag aaatcacaaa atcatgaaat tatatttaat attgttgaga    11340

tcatatagca tgtaaaatgt ctatgcttct tttggagttt taatgtaaaa catttttttg    11400

caaaatgagt tatttgggag ttatttggag attgtggtta aatatggaag atagaatgca    11460

tatgttttac cccaccctct caaaatgcca atagaatgac agcacggggg aaagaacagt    11520

ataaatatac aagaacaaag agaaagagaa tggaaaacac agaggacaaa tgatgtcaaa    11580

acacttggaa gaccaaaagt gggtggagaa gtggtaaatc acttagcaga tcagggtttg    11640

ttaaaccacg gtgcctccag agggggataa aaatgagaat aaaggcattt taccgccccc    11700

gctgcccaac aagccccaga ggccctgcaa gtgttgacat gatacaaata gcaagaaatg    11760

gaagcagaaa gaggaaagaa catgtgagca gagtatgttc acttactgct gcttctataa    11820

taacaagaag ttaaagagta ttatttaaag ttgacaaata aagaaatgga caaaataatt    11880

acacttgaca gtacaaaggt aagcacaaaa agatattatt aaatacagtc agataatgga    11940

taaaacagag aggaaaggaa tcaccaaatg gaaatgagag attttgatta aagaaatagt    12000

acactaagga caatgtatta cacggtttta attataatta taaatttata ataagttttt    12060

acttataaag acaaccacta ggataaagat acaaactctt tagtaatcta tatatttgta    12120

acaaataata tgacaaactc taaatactgg aagaattgta catcaaaaaa taaaaagcaa    12180

ataagagatg ccaaataatg aaaaggtaca aaagtaattg gggtttcaga ccataaatat    12240

taaatcatta taactaggct caaacacatc tttattaatc aaagtaggaa ccattacaat    12300

caacacattt ttgccaatga gaaatgagtt tgtttattcc tgtagcataa aaatccatgc    12360

tttgggattc aatgaactct tggaaggcat tttctgcatc ccgctggtta tggaagtgtt    12420

tcacctgcaa aaagttgttc agatgcttga agaagtggta gttggttggt gagaggtcag    12480

gtgaatatgg tggatgaggc aaaacttcat agcccaattc attcaacttt tgaagtaact    12540

gttggttgtg tgacatgcag tcggttgttg tggagaagaa ttgggccctt tctgttgacc    12600

aatgccagct gcaggccttg cagttttctg tgcatctcat cgatttgctg aacatatttc    12660

tcagatgtaa tggctttgct gggattcaga aagctgtagt agatcagacc ggcagcagac    12720

caccaagcag tgaccacgac tttttttggt gcaagttggg ttttgggaag tgctttggag    12780

cttcttctca gtccagccac caagctggtc attgccagtt gtcaagtaaa attcactttt    12840

tatcgcacat cacaatctga ttaagaaata gttcattttt gttgcataga ataagagacg    12900

acaacacttc aaaatgacga ttttttaaac atttttcctt agcttatgag gcacccattt    12960

atggagctgt ttcacctttc caatttgctt caactgccga atgaccgtag aatggtcaac    13020

gatgagttct tcctcagctt cttgtgcagt tgtaagagga tcaacttcga tgattgctct    13080

caattggtca ttgtcaactt ccaatggcca gccactactc tcctcatctt caaggttctc    13140

atctcctttg caaaacttct tgaaccacca ctgcactgta cctttgttag caatccctgg    13200

gccaaatgcg ttgttgatgt tgagttgtct ctgctgcttt acaacccatt ttgaactcaa    13260

ataagaaaat cgctcgaatt tgctttttgt ataacataat ttccatagtc taaaataaat    13320

ataaaataaa cagcaagtaa taagtcatta gcaaaaaaaa aagtgagaaa tgcacattaa    13380

aatgatgtat aacatggtca catttattta agaatgtatt ccaatatcaa acggcaaatt    13440

tcaacaatgc aaaaaccaca attacttttg taccaaccta atattttaaa aactaaatac    13500

gtcatatgaa ataatataaa caagctaaga ctaagcaaat ctgtcatgtc actaaatata    13560

aatggatttt actcacctat ttttaaaaat gcctattaca ttacaaagca atacccaact    13620

ctatgttgaa taaaaaaaat actcctcacg gtgatacaga aaggctaaaa ttatagaatt    13680

caaaagacat aagcaaaggc aaacaaagaa agcaggatcc atgattttaa tatcagagaa    13740

agtggaatct cggtcaaaaa gcatgaaata ggacaaaaat tgcacagaca tattaatatt    13800

aaagacgata gtaatctata tctttgcaac aaataagatg gcaacaatat ttataaatca    13860

gaaattatta gagtaggagg ataaataaaa acattgtagg aatagaaatt ttcaattaat    13920

tttagccaat aacagatcaa atgtattaaa aagtatgtaa aattatagat gacctagtaa    13980

tataattaat ataatgtatc tgattaatat atagcaaact accttcccta acaatagaaa    14040

atgcacctcc ttttcaaaaa accaaacata tcaaaccaaa tattaagcca tgacaaaaac    14100

ctcaataagc tccagaaagt ggaaataata tagaaaacat tctctgatca taatgaaata    14160

gagttaaaaa aaataaccaa atttaatgaa atgagaggac tttccacttg ataattttta    14220

aaaatctctc ttaaagaatt cttggacaaa agacaaacta taaactaaaa ttatataatt    14280

tcgagggaag gaaagataaa aaacagttta atcagaacct agagagtgca gttaaagaca    14340

tacatattca gggaataagt cacagcatgg aagcatagaa tatttatatc agtaaaagct    14400

gaaaagaaat tatttaaaga cctaacaaaa ctagaaaaag gataacaaat gaaagaaaga    14460

agttaataat tataaaaagc aataaattac aaaatagaaa aacagtagat ctaataaatc    14520

caaatgctgt tgtaaaaata tgcacaagac ctttatacta aaaaataata cagcattatt    14580

gagagaaatt ttaaagtacc taaatgaatt aaaggatgtc tcatgtgact ggattagaag    14640

attcataatt gttagaatgt cagtgctgcc caaattagtc tataaattca atgacatccc    14700

caaaaaaatc ccagcagcag ctgttttata gaaattagct gaacagattt catttgcatg    14760

gatgaagtga agtttattta actattttcc tattgataga cattcacatt tatcataatt    14820

aacataatcc tcatattttg ccaccacata ttaatttttt ggtgagtatc cttacacatg    14880

tatctttgta cacataatat gagtaaaatt aaggatgaat ttctagaagt agaattgcca    14940

ggtcaaaggg gtgtacattt taatttttga gatattgcca aatcgtcttc caaagttgga    15000

tcctttccat tcccagtaat tatcaaatcc attctttagg agattttgta ttaactgaac    15060

tgttgacata attcccttta tatgcacact atgaaaagta taacatatac aaatctacct    15120

atatggtcac aatcctggga atttatgtga caggtattgg atgatgttca gcatccttgg    15180

cctcgtggaa ataatcagac tagattttct ttttgaaatg caaattgata atagccatta    15240

gttgtttcct atgttgctga gaacccagag gaagataata aatgtccttg ggatagactg    15300

gggctccaaa gatcatgctg tatacttttg aaaaagcatt aaattgtagc cagtgaggaa    15360

tcagaaacca atcttattgc catgttctta acacaatctt tttccttatc ttccctccct    15420

tccattattc cttgctgaaa cattagcttt gcacaattac ctgctgataa tggtagctct    15480

atgtctttct gcgtgcctgc ctatctgtct gcttgtggaa agataaagat agatattcca    15540

ttttctaatc ccctcttttg cttgggaaga aactagaggt tcttcctcag attgggcacc    15600

agaaggtaaa gagagcaggg ggtcaaaaat tgttaagaag ggcaagacta gaactttcct    15660

actctcccca tgccctggtt tcagagaatc attgaagggg ctctttgatg accctaggac    15720

actcacctct aagcataaca atattctgga aaacctttga caaattatag caatttggtt    15780

gtagagaaga taaatgtttt ctcacctggc aaagaacatg tgaaatgaag ctgaatctac    15840

tgcaaacggg gaagtgggtg tttaacactg catgcataaa gtattgattt gtatcttttc    15900

aaatttatgg aactgttatc attttatatg tgtgctttat ctgatgtttt aaaattatgt    15960

ttttgggatt tgcccaaatg gatacatgta gacctaattc attcattttt tattgccata    16020

tagtattcca taaagatatt atcctgtgtt ttctcctcaa agttacagtt ttcctttcta    16080

catttaggta tttcaatctc ctagaattta tttttgtatg tgtgtggtat gagataggct    16140

tccaatattt ttccatatgg attattccaa catttttttc aatacatcat ttcccaagtg    16200

gttcctacca ctgcttctgc catgcaccag attcccatgt ctactgaatc tgtttctccc    16260

agtaatctca ttgtcacatc ctgagtcaac accacgtgga tttaaatgct ctatagtaag    16320

atttgacctg gtcgattcac atgcccctcc ttatttgtct tcttgaaaat tattttggtt    16380

cttgtttctt tacttttcca tatcagttta agggtcacat tttccagctc ttttcttaca    16440

actctgtgga aactttgttt ggtaatgcac tgaattgatt tatcaccaca ggaagaatcg    16500

ccacatttac aatacgaagc cttcccacac atcagtatgg cagatctctt aatttataca    16560

ggtcttcttt aatatttttc tacattttat aatgtctttt tcctaggtac attgcaattt    16620

tggttgccct attgaatact tattattgct aaactgtctt aatattatta atttctatat    16680

agtgattttg catccagcaa ccctgctgag ctccttaaag ttaaattttt ctgtagattc    16740

ccttggactt cctatttaga cagttatatt atctgcaaat aatgacaaac ttgtttcttc    16800

ctttatgatt cttataccac ttttttattt ttcctgtctt attgaattgg ccgggacctt    16860

caacaagatg gtaattcaaa gctatgacag tgagcatatt tattttgctc ttgattttaa    16920

agtgtgtgct tctaatgttt cactattatg atgtttatga gagtctcata attacttttt    16980

atatcaattt tttccatttc ttgtttgttg agactttcat catgaatggg tgttggcttc    17040

tatcagtatt tttatattta ttgaggttat catatagtct ttcatctgtt agtatagtaa    17100

atctgtaaac taacaggttt gttagtctat ttttaatggt tccagctgat cattttgctg    17160

gattcaatta ggtgtatttc attttatcta ttttgctaaa tgaggctggc ctgtaatctt    17220

ctttcataaa ctgtcccttt gggatgttcc aactctctcc tcaattgtcc ctgggaactc    17280

caacttattc ttactttgtt tagcagagca attcatctct ctccatctcc tacaatgttt    17340

ctcaacaagt gatctaagga tctctatgca catataattt taaaatctaa catgtaagat    17400

taattattat attcatagaa tttctaactt tttatgtttt caaaaacagt gtatgtgctt    17460

caaaaactga tttcattcat aatggttaac atggagttaa tcataggcag tttatcttga    17520

ctaatgtatt ttattgtcac ctgacagtta tttacacttg tcagacttgc atttgccatt    17580

attactgtcg ctttgcataa tatcacaatt caaaaaaaag agtcatcact tcgaaagtgg    17640

ttttctgaag cataacaata atgataaaaa tagaaatata aatcctacaa tgtgaaataa    17700

ggtcacaatg taagtaatga atggcctcca ttgtaaaaat acaaagcatg aatctgtttg    17760

tcatgagaca agtggataat ggatgtggat aatctcccaa aaccagacaa aaatatataa    17820

gaaaatggga gccatgacaa tgaataatga taattgaatt ttattggacc aatgatcctt    17880

ttgtcctagt acccaattta ttatctgcta acgtttttgt caagtaatga tataaagcta    17940

tcaaaacttc catattattt tccaataaag tttatcaacc ccacttttaa accaattgaa    18000

tatctctact acaagcacaa aataaggctt tcccagtata aaattgtgaa aattttatgt    18060

taaaggttga gaagacaaca aaactataga gtcatcattc atcctcatat caaaaataag    18120

cacaattgca ctcctgctgg taagatacaa aaccagtttc caaatcaatt acaaatattg    18180

tggttggaga agaaacaaga aaaacaattg gtataattcc ttaattagaa gtattgcatt    18240

ccttataatg tgactggcat ttaaagtcaa tgactgttag gtatacgagc agacatttta    18300

ttttatagtt gaacaaaact atgaataagt aagttgtcag catatcttca ctatatatat    18360

gggaaagact cagtgacttt ttgttctatt tatcatgaag ctaattttaa aagaagagct    18420

ctctggttta attaaaaatt agtttgaacc tatgaaacag actttaaaag gtatgttggc    18480

ttatgcacta atgtttgtag cagcgttatt cacaatagcc aaatatgtcc atcaacagat    18540

gaatggataa aaaatgtagt atatatgtaa acaattgaat atcattcagt tttaaaaatg    18600

aatgagattc tgatacatgc cacaacattg acaaagcatt gtgctaagta aaataactca    18660

aacgcaaaag aacaaatgtt gcatgattcc acctttagta ggtacctaga acaggcaaat    18720

tcatggagac agaaagtaga atggaagttg ccagagaggg ggaatgggga gttattattt    18780

aatgggtaca tttctgttcg ggattataaa aaagtttgga aacagatagt ggtgatagtt    18840

ccacaatact gaatgtactt aatgccacta aattgtgtac ttaaaaatgg tgaaagtggt    18900

aaattttatg ttatgtatat tatgcatatt ttaccaaaac ttttttttaa aagaggaaag    18960

gtgttaaatt gccattgaag aaactccagc cacatggtca gcaaggaaag gtatcactat    19020

ccagatagaa gatgctgctc ccagatccca atgctagtgc ataccttatt cacggaacgc    19080

agctgggggt ctgtaatatg cctccagatt ctgatttgct gttgaggtac acagtggaaa    19140

ttgtgaatac aaactgattg tggtcactta gtgtacatct ctttggccta ctgggctgaa    19200

atgaaaagtg agtaagagag gctgctctcc cacactgaat tgctttggct ggcaaatggg    19260

aagggcttac acagagtttt aaaaataagg aatgaaatgt tttaaattac catttttatg    19320

aatacaagtt gggtatctca gtgatccatt cagaatttga atattatgaa tctttgtttt    19380

cagagcctga atatcgggat ttgtaacaat cagacatcag tggtgcaagt ggctcaacgg    19440

ctgagaactt gactttttcc caatacccaa tgattttctt cattcaccag aaaaagcact    19500

taggaaataa cacattgggc ttattaaaaa ttacatctga atgctgcaac ccaacatcaa    19560

gaaatacctt gcagagccaa ataccaccaa agagaggatg caactccatt agctgctgtt    19620

gagctggggc acttgccttc tggtgaagca ctgaaaatag tctttagaga gcactctctc    19680

cataatttct gggtctgtgt ttgatttgac aaaccagaaa tatccatcaa agcttcccaa    19740

caacctataa ttctgagtta agattttcta atttagaaaa cataaagagt gtggggggga    19800

aaccaacaag atatggaagc tgacagctca agcagctatg caaccagata tagattccta    19860

aatgatttca aacacgattt ctcctctcac agatgtgaaa aaaaattatt cactttttaa    19920

cttgactttt acttttattt aagacatata tgttcataat ttaaaaggtc acagagtttt    19980

ataaagattc tgacaaaaaa aacagcaatt tcatttttct catctcttct ttccagaggc    20040

caccactttt agcttttttt acctgtgtct tctgatacct ccctatctcc aataatatac    20100

tcataatact aatttttaat ttttcaattt ctgatgttat ttattggctt cctattatga    20160

gaaaaaactt aaggccacat ccacaaactc atttcctctc accctcatct tcctgttaca    20220

gttatattgt aatcttcagt tagatcatca gataatatat ccattgtatg actacatata    20280

taattacatt acattgctaa gtaaacactg tttacagctg tgtcatgcag tgtactttga    20340

ctatatttcc tttttgcaca atgtttttgc tttccttgga gttaataagg attttatttt    20400

tttgtttgct cagttttcta tttatcccta atttgttccc aaactcttct ccagatgttt    20460

aattgttgct tcaatttatt tgcacacatc aggtgcatgt gtatcatttt tttcctatgg    20520

gaatcacagc tagagtactt catcttctgc ctcattctga cctagatgtt ttctaggcct    20580

gatgcacagc tgttttctag agattttttc ttcttcattc tttttttgga ttccttttgc    20640

ctcttccctg gatcgcatat atgtttcttg tttgaatgga gcatatcctc tagtaacatt    20700

tttttttaag acaaagtctc tctatgctgc ccaggctgtt ggcctcaaac tcctgggttc    20760

aagtgatcct cctgcctcaa cctcccaagt agttaggact acaggtacat accaccatgc    20820

ccagcttcta gtaactttat tagaagggta actaagaagt acatttccca agacttcata    20880

tattctacct tctttgacag tttggctagg gaaagacttc tgtattagaa attatttccc    20940

tcttaatttt gaaggccttg ctcattgtct tctaatttct ttctagacct cctattagtc    21000

aaacaatata cctcctagtc tgattctcta attttcaaac tttttatcac ttcctatcca    21060

tttctgcttt tttgttccac ttcctgtgag atttccaaaa ctttatttac aagtccgcct    21120

attagtgttt tacttttgct atcatatttt tgttttcaaa attccatttt gtctttgaag    21180

gtacttttta catccttctg ctcttgttct atacgtggag cctcttctca cctcttaact    21240

ctctaaaaat attagtacag gttttttttt ttttgttttt gtttttgttg ttgttgttgt    21300

tgctgttgtt gttgttgttt tggagacgaa gtcttgctct gtcacccaga ctggagtgca    21360

gtgacgcgat ctaggctcac tgcaagctcc gcctcccggg ttcacgccat tctcccgcct    21420

cagcctccgg agtagctgga actacaggtg cccgccaagg cgcccggcta attttttgta    21480

tttttagtag agacggggtt tcaccgcgtt agccaggatg gtctcgatct cctgacctcg    21540

taatctgccc gcctcggcct cccaaagtgc tgcgattaca ggcgtgagcc acagcgcctg    21600

gccaatacag ttttatttct ctaactcttc ttctgccctc tttattgtct ctttttcttt    21660

tcttttcttt tctttttttt ttttttttca gttgtttggt tgctttggtt tctggtgtta    21720

gaagcatcct tcaaattcct gatgctcctt ggctggctgt tcatgttaaa agtgcagcat    21780

cttcatgggc tctaaaccag attatcttct ggaaacttaa cgaggagcag aagtgaatag    21840

ggaggggagt tgtttgcctt tcagtaggta aacttttctt tatatgcatt tttcagtatg    21900

caactgtttc cctcttcttc aactcttaag aaaatgagca tccaatccat ttctggagca    21960

gaaacagttt ctcattgaat ggatggcata aagcagcatc tagaaagctc aactggttcc    22020

tgtaaaaaac tttcaagcaa ttctttcagc cctacttatc accctccccc aaaccttgct    22080

ttcagagata cttagcatct ctaagttcca agcagttctg gggctctgca gcatagcttg    22140

gcttgcttct gggtattccc tgcttcagcc agttttcagc tttcttaggt ctgctctgtc    22200

agttaccact catcagtctg cactccagtt tctaaaaact gggagttttt agatgagcct    22260

ccagcttctt gcaggatagg gaggccctgg cagacataaa caggagaatc cttgctcttc    22320

acccgctact gccctctgcc taaccccaga acagcagaag ctgctggctg tcccagccac    22380

acacatccct ccccactcca tctatttgtg tggcccttct ttttccctca gtctgtgtct    22440

tgtttcctct ccttaccttc ttccccctca tcaccttggt gatattcttt gcatgttttt    22500

tcttggagca gtcagagcag gtcatccctc cctcctggaa gaaggaaccc cctgagtaca    22560

ctccatggca cagttgacac tccttttcta ccctccttcc cagatatgtc ttcactgtca    22620

tttacacctt tgaagccttg ataaagatac tggcaagagg attttgtcta aatgagttca    22680

cgtacctgag agatccttgg aactggctgg attttagcgt cattaccctg gcgtgagtat    22740

atctctatgc agatctgcat gtgtgatagg agaggggaca aaatggtggg taggagacag    22800

ggctaacatg caggtcccac ttggacagag tgtggagact cacaccatga acgtttgctc    22860

caagaaccac tgcaggaata taccaggaga actgaaagaa ttcatagatc cttttaaata    22920

agtggcacac tgctggaaat tctgcaagac aggtgaaaaa ctgtgagctc ccaaagtgtg    22980

agggggggaa acctgcctcc aaacatacat cccaactggg taatctgaaa atccagatca    23040

caggagaaga atttaccctt acctggaatg taaataaatt taggaagcca cacaaaatat    23100

aaaagtagaa acagcaaagg gaagtgcctt gtaggcactc ccagtctcca gcttgagacc    23160

agggaatcca tccctgacta tgtctcacag gcacccttgg ggaaggcagc cagtggaatc    23220

agggaggggt cacaggatga aagaagtttc aactaaaatt agtaataatt tcaactgggc    23280

acaaattttc ttgagcagaa tccagggggc aaatgggaac tgcaagcaga cagtgaggga    23340

tgcggtccaa aagtcatgct ttctttctca gtggggaagc tcacagcctg gggcaaggtc    23400

tgagtagggc actgcaggag caagaccagc ctcaccaact acatgagagc taggtgaggc    23460

ctctcactag cagctatccc ccacttccct ggagaactct atggcacagc agaggcagcc    23520

aaaattccct ctggaacaca accccactgg cctgagaacc aacccccatc caccacagtg    23580

gccacagcaa tccctaccca agaagggtct gagtctagac tcacctaccc ctgcccccac    23640

ctgatggtat ttccctacct gccttggtag ctgaacacaa aacccagaaa ctctcggaag    23700

ctttatggcc ctgctcatca cctaagaaac taaaatattt accctggcca acttagggtg    23760

agcttagatc ccccttctac taatgcacta gtgctctctt gaaagcatca cctaccggct    23820

ggaggtcaaa cagctcaggc cattaaagca actcatgaca gaataacttt gatcccagga    23880

aaaagaaaac aacaaccagt tgcactgcct gcaacatcct ggctaaccag acgtcctgag    23940

tctgtccata tgacaacttc actgctaaca taactagcat tcaagaaagc cagcacacta    24000

aatctatcta cagcctagga ctctcacaga ctctacttca ttcctctgcc accttcacca    24060

gaacagatgc tgatatccat ggctgggaga cttcaagatc aatcacatca caggactctt    24120

gcaggcattt cccagtacta ccccagagcc tggtagcccc tctgtgtggc taggcccaga    24180

agaacaataa cgatcactgc agtccagctc tcaggaagcc ccatccccag gggattgggg    24240

agagcaccac atcaagagat cacccatgaa acaaaagaat ctgcacaaca gccattcagt    24300

tccagatctt ttctctgaaa tagtctactc aaatgagaag gaaccagaaa agcaattctg    24360

gtaatatgac aaaagagggt tcaataacac ccctcaaaag atcaaactag ctccccaaca    24420

atggatccaa actaagaaga aatctctgaa ttgccagata aagaattcag ggctgggcac    24480

agtagctcac gcctgtaatc tcagcacttt gggaggccaa ggtgggcaga tcacctgagg    24540

tcagaagttc aagaccagcc tgaagccaac atggagaaac cccgtctcta ctaaaaaata    24600

caaaattagc tagatgtggt ggtgcatgcc tgtaatccca gctactcagg agactgaggc    24660

aggagaattg cttgaacctg ggaggcagag gttgcggtga gctgagatcg cgccattgca    24720

ctccagcctg ggcaacaaga gtgaaaatcc atctcaaaaa aaaaaaaaaa agaattcaga    24780

aggctgatta ttaagtgatt caaggagaca ccagagaaag ataaaaacca acttaaagaa    24840

atttttaaaa caacaagata tggatggaaa attctccaga gaaatagata taaagaaaaa    24900

acaatcacaa cttctggaaa tggaagactc acttagagaa atacaaaatg cagtggaaag    24960

tttcaacaat agactagaac aagtagaaga aagaacttca gagctcgaag acaaagcttt    25020

taatagaccc aaactaagac acacaaaaag aaagaatttt taaaaaaatg acaaatcggc    25080

caataaattt ggaatcatgt gaaacaacca aacctaagaa taatgggtgt tcccaaggaa    25140

gaatagaaat ctaaaagttt ggaaaactta tttgagggaa taattgagga aaacttccct    25200

ggccttgtta gaaatataga tatccaaata caagaagctc aaagaatacc tctgaaatgt    25260

gtcacaaaaa agatcatcac ctaggcaaat agacatcagg ttatctaaag tcaagacaaa    25320

gaaaagaatc ttaagagctg tgagacaaaa gcctcagata acctataaag gaaaggttat    25380

ctgatttaca taagattaac agcagatttc tcaactgaaa ccttgcaagc cagaagggat    25440

tagggtccca tctttagcct cctgaaacaa aataattgcc agccaagaat attgtatgaa    25500

gagaaactaa gcttcataag tgaagacaag ataaagtttt tttcagacaa acaaatggtg    25560

agagaatttt ccactaccaa gccagcacta caagaaatgc taaaaggaat tctaaatctt    25620

gaaataaaac cttaaaatac accaaaatag aacctcctta aagcataaat atcaaaggac    25680

ctataaaaca ataacacaat aaaaaaagga attaaggcaa taactagcat aatgaataga    25740

agagtacctc acatctcaat actgatgttg agtgtaaatg ccctaaatga tccacttaaa    25800

atatacagaa gggcagaaag gaaaaaaaaa atccaccaac caagtatcta ctgtcttcaa    25860

gagactcacc taacacataa ggagccacat aaacttaagg taaagagatg ggaaaagata    25920

ttccatgcaa atggaaacca aaagcaagca ggagtagcta ttcttatatc agagaaaaca    25980

gaccttaaag caacaacagt taaaaaaaga caaagaggga catatataat gataaaataa    26040

ttggtctaat ggaaaaatat cataatccta aatacatatg cacctaacac tggagctccc    26100

aaatttataa aacaattact actagaccta agaaatgaaa tagacagcaa tataataata    26160

gtgggggatc aatattccac tgacagcact agacaggtca tcaagacaga aagtcaacaa    26220

agaaacaatg aacttaaact gtaacctaga acaaatggac ttaacagata tttaaaaaac    26280

attctaccaa acaactgcag aatatacatt cttttcatca gcacatggaa tattctctaa    26340

gatagaccac gtgatagata acataacaaa tctcaataaa tttaagaaaa tagaaattat    26400

gtcaggtatc ctctcagagc acagtcgaat aaacctcgga gttaactcca aaagaaaccc    26460

tcaaaactat acaaatacat gaaaactaaa caatctgctc ttgaatgatc tttgggtcaa    26520

caatgaaatc aagatggaag tttaaaaatt ttttgaactg aatgataata gtcacacaac    26580

ttatcaaaac ctctgggata cagctaaagc agtgctaaga ggaaagctca tagcattaaa    26640

tacctacatc aaaaagtatg aaagaggaca aatagataat ctaaggtcac acctcaagga    26700

attagagaaa caagaacaaa acagacccaa accaagcaga agaaaaggaa taacaaagat    26760

cagggcagta ctaaatgaaa ttcaaataaa aataataata atacaaaaga taagtgaaac    26820

aaaaagcggg ttctttaaaa agatatagaa aattgattga ccattggcaa gattaaccaa    26880

gaaaagaaga gagaagatcc aaataagctc aattagaaat aaaatgggag atattacaac    26940

tgataccaca gaaatacaaa aaaaaaatca ttcaaggcta ctatgaacac ctttatttgc    27000

acaaactaga aaatttagag gagatgaata aattcctgga aatatacaac tgtcttagat    27060

taaatcagaa agtaatagaa actctaaaca gaccaataac aagtagcgag attgaaacag    27120

taattcaaaa attgccaagg aaaaaaagtc caggagcaga ctggattcac agctgaattc    27180

tatcagacat tcaaagaaga attggtacca attttattga aactattcca aaagatgcag    27240

aaagagggaa tcctcctaaa tcattttatg aagccagtat caccctaata ccaaaaccag    27300

aaaaggactt ttaaaaaaga actacagaca atatccctga tgaacataga tgcaaaaatc    27360

ctcaacaaaa tgctagctaa ttgaatccaa cacatatcca aaagataaca caccatgatc    27420

aagggggttt cataccaggg aggtagggat gatttaacat acacaagtca ataaatgctg    27480

cacgtcacat aaacagaatt aaaaacaaaa atcatatgat catctcaata ggtgcaggaa    27540

aagcatttga caaaatccag catcccatta tgattaaaac cctcaaccaa attggcatag    27600

aagggacata ctccaaggta ataaaagcca tctatgacaa atccacagcc aacattatac    27660

caaacaggga aaagttgaaa gcattccccc tgagaactga aacaagacaa ggatgcccac    27720

tttcaccatt tctatccaac atagtactgg aagtcctagc cagagcaatc agacaagaga    27780

aataaataaa gggaatccaa atcagtaaag gggaagtcaa actgttgctg ttcaccaatg    27840

atatgatcgt atgcctagga aaccctaaag actcatccaa aaagctccta gatctaataa    27900

atgaattcag taaagtttca ggatacaaaa acaatgtata caaatcagca gcactactgt    27960

acaccaccag aaaccaagct gaggaacaaa tcaagaactc aatccctttt acaacagctg    28020

caaaaaaaaa acaaaaataa aaacaaaaaa atcttaggaa tatacctaac caaaaaggtg    28080

aaagatttct acaaggaaaa ctacaaaaca ctgctaaaat aaatcacaga tgacacaaac    28140

aaatgggaac acatcccatg ctcatggatg gataaaatca atattgtgaa aatgacctta    28200

ctgccaaaag caatatacag attcaataca atttccattg aagtaccaca tcattcttca    28260

cagaaataga aataacaacc ctaaaattca tagggaacca aaaaggaatc cacatagcca    28320

aagcaagact aagcaagaat aacaaatctg gaggcatcac cttagctgat ttcaaactat    28380

actacaaggc tatagtatag cctgtaccaa aacagcatga tactggtata aaaataagca    28440

catagaccaa tggaaaagaa tagagaactc agaaataaag ccaaatactt acaagcaact    28500

gatctttgaa aaagcaaaca aaaacgtaag tggggaaagg acaccctatt caacaaatgg    28560

tgctgggata attagcaagc cacatgtgga agaaagaaac tgaatcttca tctctcacct    28620

tatacaaaaa tcaattcaag atggataaaa ggcttaaatc taagacctga aattataaaa    28680

aattctagaa gataacattg gaaaaactct tctagacatt ggcttaggca aaacgttcct    28740

gaccaaggac ccaaagcaaa tccaacaaaa acaaaaataa atagatggga tctaattaaa    28800

ctaaaaagct gttgcacagc aagagaaata atcatccaag taaacagaca acccatagga    28860

tgagagaaaa atctttgtta tctatgcttc cagcaaaaga ctaatatcca gcatctataa    28920

gaaacacaaa taaatcagca agaaaacaaa caaataatcc catccaaaag tgggcaaagg    28980

acaagaatac gcaattctca aaagaagata tataaatggc caatgaacag gaaaaaaaaa    29040

tgctcaacat cattaattat cagggaaatg caaattaaaa ccacaatgag ataccacctt    29100

actcctgcaa gaatggccat aaccaaaaaa taatagatgt tggcatggat gtaatgaaaa    29160

ggaaacaatt ttacactgct ggtgggaatg taaactagta caaccactaa ggaaaacgtt    29220

atggagattc cttaaagaac taaaagtaga actaccattt ggtccagcaa tcccactact    29280

gggtatctac ccagaggaaa ataagccatt attaaaaaga cacttgcata tgcatgctta    29340

tagcagcaca gtttacaact gcaaaaatat ggaaccagcc taaatgccca tcaaccaaca    29400

agtgcataaa gaaaatatgg tgtatgcata ccatggaata ctactcagtt gtaaaaagga    29460

atgaaataat ggcattggca gcaagctgga tggagttgga gactattatt ctaaatgaag    29520

taactcagga atagaaagtc aagcatcatg tgttcttaat tacaagcagg agctaagctg    29580

tgaggatgca aaggcataac aatgacataa tggactttgg ggacttggga ggaaaggtga    29640

gacgaaggta agggataaga gactacacac tgggtacagt gtacactgct cgggtgatgg    29700

tgcaccaaaa tctcagaaat cagcgttaaa gaatttttct gtgcaaccca acaccacctg    29760

tttcccaaaa ctattgaaat acaaataaag aacttattca tgtaaccaaa aaccacctgt    29820

tccctcaaaa ctattgaaat aaaataaaat aaaaagattt gcatgggtgt ccatgtgggg    29880

cttatgggtg tatccaggct cacactctga agaaggttct tcatctcagt tcagcttcct    29940

catttggaat tgtatggcct ggggttcttg ccacagagta ccgcttcggg ggttgctttc    30000

caagattagt cccatgccca tgaggagatg tcagagacct caaatctgag ataacagtta    30060

gcctgtcaca gtggatcaga aaaggcccag ccttgtaccc ccctgacatg gcggtctcct    30120

tctgagaaat cagtgtctga ggagactggt tggtcaaact cctgtgtttg aagatccgtc    30180

cacatgcagt gttgcctaga tcacaatgca tcttctcaaa gggtccactc tgaaagatgt    30240

tgcaataatg aaatcagtgt cagtgtcagt ctatagatgg cagtgtcact agattctaag    30300

tgtccattct gcatcctttc taggctaatg ataccccagg ttatccttat ttatgctgca    30360

tgcatcccca ggacccttgc ttgcagagat gctgactaac ttctggtcct acagatatgt    30420

tggcacagca atagatctcc gtgggatctc aggcctgcgg acattcagag ttcttagagc    30480

attaaaaaca gtttctgtga tcccaggtga gcatttattc acagagcata tgttggtttt    30540

cacagcctaa ctcccttctc taattttcac aagaaccctg taaggttcca gggcaaagac    30600

tattgtcccc acttacaaga caaaggaact gaggcctgga gtataggaaa cataaaccca    30660

aggcctcttc actagtaaga gacagtgtga cctggaagcc tattgtccca actcctaggc    30720

cagtgctctt cccacatacc acatggcctc acaatcaata cgtaacagga ggggcatgtc    30780

ttcactttct gttctggttg tgggattcag gcaagacccc tcagttgaat ttttatttat    30840

accttaaact aaaggattaa acttggaaat ggggaggaag ggagaaagca gtcccagtat    30900

cttcactgtt tccgtaggtc taaaatcctg tctttagaca cccagaggaa aaaagaatta    30960

ggcaattctt gattactgag aattcagaaa caaaagtagt ccatcaaagc tcattgtgtg    31020

gggcctctaa gatctccact gtcaccagta gcccagcgac tactcttcag cccccatgag    31080

gttgatggtg aggatgggga ggccagagac aaggcaaact ttctgaaatg ggacttgatg    31140

cttcccctct gtggcctgat aggttctctc ctctcacccc aagaattcgt tctcttatct    31200

gtaaacagaa acacccattc tagagtggaa gtcttttcta ccatttcttg tctggctctg    31260

cagggaaaga taggaaactc tctgccaatt cccactggac acacctcttg aagagagccc    31320

tggtcctgcc ccttcatatc tctctcactt actctcaact gggaagaccc tgagtcttat    31380

ttgcaagacc tggtctgtcc atactgtctc ttctgcctca tctctcacct ctcctcacat    31440

ctcaccatgc tctggaatcc acctacggtt ctgcaaatac tccacaccat tgctcacctc    31500

ccagccttct actgtgctgc cccttcttct gggatatcct tcctcctctc tttactcaac    31560

tcacactcat tcctcagggc tctgccaagg ttttacctcc tccctggttt tcccaccttc    31620

ctcacactcc acccacccca ttcccacctc tggaacttca gttaagggct gctcccctgt    31680

gtgcccatct gctcagtaat gctacagact ttcccctcaa ttgtcagaca acggcactcg    31740

acatgctgct gccttagcca tcactcagct cccagtccag ggactgacac atgtagtgct    31800

cagtggatta tttgctgacc aaaatgacta accaaaaata aatcctagat tgcttccctg    31860

gtcagagctc tttctgctac ctgcgaagct gctctcccaa agaagttgat tttacttacc    31920

agagcaacaa atcatccctc cttaaacaag caggtgtatc cttctttgct gccagctgtg    31980

cttggcacaa gttctattta tgccccagtg actgtctcag tgtttcttat agtctctttc    32040

tattgctaaa ctcacctctc tgtttctctg tgtctctttc tttttctttc tcttggtcta    32100

tttttgtttc actctatctc tcttgcatct ctctctctct ctctttctct ctctctctct    32160

ctctctctct ctcacacaca cacacacaca cacactcaca cacagtgagg ttcatgtgtc    32220

ccaagtctca agctgcctcc cagatgcatg cagaaagaca gatgccaaat tactggggtg    32280

aagttagtag cttcatgcct agcacagtgc ctggaaaaag taggtactca gcataaatta    32340

tttaaattga attgctagtg tcaggaattt tattagcctc aagatgataa aaaatgcatt    32400

gcctgggtct cagttgcatc gtctttataa tgagaatagc ccctgactct ctgcctgcct    32460

ctcagagtaa atgcaagctt cggatgagaa aggtcttgga actgccctgg agtgtgtaca    32520

tacttcactc ctgtatgtag agatgaagga ggatggctaa gatgaagaag tgtgctccgt    32580

gtgtgctacc tcatccatgt ggtcatacca ctgtcatctt cccgcaggcc tgaaggtcat    32640

tgtgggggcc ctgattcact cagtgaagaa actggctgat gtgaccatcc tcaccatctt    32700

ctgcctaagt gtttttgcct tggtggggct gcaactcttc aagggcaacc tcaaaaataa    32760

atgtgtcaag aatgacatgg ctgtcaatga gacaaccaac tactcatctc acagaaaacg    32820

tgagtggagt ctcttccata gggaccaagg tctggttgga cccttggtat catataggga    32880

caggggatat ggagcccctg tgtgtgtgta tagacatata ttttgactcc cctttcctgc    32940

caaaatggtt ctcttgagtt gtgttttact tttgggtatt ctatttcctg ttgctcagca    33000

tccctcttgc aaggaaatga gccataaatc tagaggcaag tcattctacc tctgctgggg    33060

gagattgaga gccgaagtca ctgcttagct cttctctttt cagatgtgac tttacaactt    33120

ccatgtggcc cagcatgccc actgagtaca tgtagccaaa ggagctcact ttggaagact    33180

tgggaatatt gcattcacca cacaaggctt gggttggagg gttcagaacc atctgtgagg    33240

ctttcttttc ttcctttctt cagcagatat ctacataaat aagcgaggca cttctgaccc    33300

cttactgtgt ggcaatggat ctgactcagg gtgagttccc aacttatgac aaagcacgag    33360

tgcccaacaa ttccttctcc atcttgtcct tggcatatta tgggcacaga tggggttgca    33420

ggtcctggga aagatgtata aataaataaa tcatggcctt tgccaaccca gagctcatgg    33480

ggagggaatg tatgagttag ctttcgctgt gtaacaaatg accccaaaat tttgtgaatt    33540

aaaacaacaa tgtatttaat tcatgattct gtgcatcagc attttggact gggatcagat    33600

gggcattggg tgacattgac taggctcatt catgcatatg cagacagcat attaacttgg    33660

agatggctgg tctaggacgt cctgtctctg ctcatgtggc ctctcacccc caaacaggtt    33720

agcctgggcc tgttctcatg gcagtgttcc cagaaaaaca gtggaagttt gcaaggcttc    33780

ttcaggccta ggcttagaac caacacaatg taccttttgt acattctgat acattcttga    33840

ctaaagcaag ttgcagtcca gtagagatcc aagagacaga gaaatagact tcatcactca    33900

atggaaagag ctgaaaagtc acattggaaa gggtgtggat acatagagac aagaattata    33960

gccattttaa taaataatct accccaggaa ggaaccaata cttatttgtg tcaaatgctc    34020

tacacttaat catcacagct aactccattc tatagccaca ttaccctcac aagtagagga    34080

aaaaacacat gtatcagact ttgcaatttc gaattcttac agaggccaga ttcataacaa    34140

caaatgagtg gagtgggcca ggagggaacc taggagctga gagttcatgc ctcctctaaa    34200

ggggacagcc ccactgctcg gtccagcttt tggttgccat gtggaaatgt gggttcactg    34260

tttccagctc ttccaacttt taaaatagag ataggaaatt tagattttta tataaaatct    34320

cccaaccgta aacattggct acctattcca aaaaatgtct acatattgtt gggccaaaca    34380

aaatatttct gtgggccaaa tccagcctat aagctgctag tttgcaattt ctcattcata    34440

gacataaaga tgctaccctg tggaaaacaa gttctttact agaggcttca taggctgggc    34500

aaacacagtg aggtggcggt gtgaggcaag agagaaagta gggaaggctt cctggaggtg    34560

gtgtttgagg tgagctttca agggcaggta ggatgtctcc aggctgggtg aatacgagat    34620

agtttcagcg aagaccattc caggtggcag aacagaatgt gagacaaagc taagggatga    34680

ggacccctca gctctgcctg ctgctttggc cactggagga aggcatgagc agaaagactt    34740

taggcaaaag atcaaaaagg cccatctcac ccacctccat ggctgagagc ttggaaaagc    34800

agagctcaca acacccccag tgcctgagag gctgacggct ccatgttgcc caggtcgacc    34860

tgtgtggagc ctgcatgagg ctccaccttc atcagctcac taggaaaact atctcagttg    34920

gagctgagga ctggaaacaa gcaggagcat ttggtcaaca tcaggttcct tggactgttc    34980

tttcacaaat gcacttggca tttggttctt tggctcatga gagggttgtt ctgacatcag    35040

ttttcatttg cctttgactt aaatgtaaac caagagcccc tcagcatcct tctgtctaga    35100

taatggcatt tctcaaggca atggctccag agcagctcaa gtcctttttg tggtaaagtt    35160

gttgggtcca tctacacacc tctacagctc agctccctga gaggccaggc ctgctattgg    35220

gcaggtgcca gccaggcagt gggggagtgg accaggctgg gatggcagag agaggccagc    35280

tcaggataac ggacagagtg aaccctgccg gggcatgccg tgaaagctaa acctgggtcc    35340

tctgtggggc tgcagagaag ccagagtcct gaggaaaggc ccacattggc caatggcact    35400

gtgggaggaa ggtcaggggt ctcaaggcag aaaatggata ccagaaaata gttgataatt    35460

ttcagtgttc ttccacatat attattccag tttatccttt cagcagcttc caaggttaaa    35520

aacaatagga attttccttt gcagtttata tacaatattt actatgcaga agtgcaagac    35580

actatacagt gatctcattt aatcctcaga gcagtgaact gtttatatgc agtggctatg    35640

gtggatttct acagaagaca tagaaacaag gctgccctca gagttaatta agaaacctac    35700

aggaaatggg ttgcctagcc ccttggaaga gcaaaccaag agcctatctt taaatgtggg    35760

tctacaaagc cagggaactt gcaatcttca atcgaagtgg agatagactt ggaactgatt    35820

agaattaagt tgtcagagct ctaatccatg gtatgggttg ttcacatgga tgtctgggat    35880

aaggagagcc ccagaggttg gagttcatgg agaaatcctg ggagtaaaag aattccatgt    35940

attcacaagg aatgcaggta aataaaacag gagaaaaaga aaaaaattta aaaaaataat    36000

tctggacttc aaacgaggca ttgctgtttc attgatcagg ccatctctgc tagggtggat    36060

gagagcactt tacgctccct gagctgacag atgcttcttg acatcgactc atcctcctat    36120

tatgagagag aggaaggagt tcagcattcc cacctcaata ctcaccaggc agtcattttt    36180

aatctggcct tccttcatag gccatcttca ggaggaggct aggctgactc aagtattggg    36240

ctacttgaca gttatatttc tccttttaat aaatatattg acacctgcgt agttttaggc    36300

aactgacttc tttctgaccc ccagattcct tatctgtaaa gaaagaacat tgagtgatta    36360

aattatagtg tttgtaaagc acttaaaggg agagagaaga acacagaaag tgctcagtaa    36420

gtggaaagtg ttatttccac tgttacatat aattaatcag tgaacttggc taatgtgaga    36480

cctcccttga tagacaactc tgcagatgat gccaacaggc tcaggtttta agtctgcgtt    36540

attgctactg actctcattt ccctggtatg aactggcaaa gagcttatag tatcgtgtct    36600

gggcagtcag ctgccttccc caggccactc ccctgtgtat gaaattctga cgtgaaagta    36660

ttagcgtccc cgttttatgg ataacagaaa ccaataccta aacagaccaa gtgtccaaga    36720

tcatcctgct aataagagga agactaggtc ttgaactctg atctctgaca taaaactctg    36780

tggttgtctc gcagccctgg gctaccttgt ctgcaataag caggggatga ccttctctgt    36840

tcttgctgca gccactgccc tgatggttat atctgcctta aaacttctga caacccggat    36900

tttaactaca ccagctttga ttcctttgct tgggctttcc tctcactgtt ccgcctcatg    36960

acacaggatt cctgggaacg cctctaccag caggtactga gctgcattcc cccacgcaga    37020

cttggttgga ggctggtggg tcagctgcat ggctgtgctt ttcctggagg aggctgactt    37080

aaattcaggg gtccatgtgc tatgggtaca ggtttctctt ctttcccttg aacctgcaga    37140

ccctgaggac ttctgggaaa atctatatga tcttttttgt gctcgtaatc ttcctgggat    37200

ctttctacct ggtcaacttg atcttggctg tagtcaccat ggcgtatgag gagcagaacc    37260

aggcaaccac tgatgaaatt gaagcaaagg agaagaagtt ccaggaggcc ctcgagatgc    37320

tccggaagga gcaggaggtt tgtgaggagt ggaagctttg tgaagaaggt tgcagactgt    37380

ccattcttgg atactgttct ggactagcca cttcaattag ggcaccgttt agggagctat    37440

aggaggaatc atcttgcctc agggaccata ttagatcagg ttttctcaaa gaagaagcta    37500

agtgaggatt cttgtgcaag tgacctattg agggagtgct ctcaggagaa agcgaatgaa    37560

gcaaaacaga atggggcaga gggtggaact aaacaaggag tgttctcagc tagagaccag    37620

cttcagcttg atcccatggg gaactctggg gcatgacctg taccacagtt agtcctacct    37680

tgaggcaagg gggccagctt ttttttttta ccctccccat acctatccca gaagcaggca    37740

gccaaaagag actttttttg tagaatgctg caagtatgag ccatcagctg ctgccatgca    37800

agcagctcgg gatagctgtg ctgacctggt gaaagggatc tgggtggggc accaacagag    37860

taccccatga atgagtgggg gtgacccgag gtgtctgttc ctgccatggc ctaatcccac    37920

caccaccctg gtcctaaccc ttcagcttct ctgtttcaga tctctcaccc ctggcacccc    37980

atgtctgggg gacacattca tgctaagtcc aagcaaatac tattggctac acctgctgtt    38040

ctctcttcgc aggtgctagc agcactaggg attgacacaa cctctctcca ctcccacaat    38100

ggatcacctt taacctccaa aaatgccagt gagagaaggc atagaataaa gccaagagtg    38160

tcagagggct ccacagaaga caacaaatca ccccgctctg atccttacaa ccagcgcagg    38220

atggtaagag gctcaggttt gtgctctaaa gattacccac cattgcagct gccgtagaca    38280

atgagttgga gtgggaagag gtgtgtggca gagaaagagc tggaggcata gagcctaaaa    38340

ggatccagac acccctccaa aatggtgtct taaactagga aagtgtaatt atagatgggg    38400

aaaaggggtg aattataagg acaccttagg gaagtggatc aacaagattg ggattgtgga    38460

ctgtggaaaa aggaaagggg agtccaattt gactcccagg tttcaggatt gggcaatcaa    38520

atgggtggtg attccaagat gaggacactg gaggaagaac cccggtttgt aggaaaggtg    38580

ggaagcccat actgaacatg ccaatcttaa ggtgtctgcg gacatcaaag gtcagcttcc    38640

ttctgaggct ctggtctgca gttctagagt gcaaggttcc ctgtccgtgg tgctgagatc    38700

cttcatgcac cttttttttt tctgatgcgt cgaggtggtt tttatttttt tacttagttt    38760

tttttaattg acacttcaca attttatata attattgggt ataatttctg acctccttcc    38820

taaggtcctg caattcaagc tgtcacctgt tgttatcaga aaagtttcca gcacccatct    38880

ctgtgacaca atccagcctg ggaatggctt cagcacctca cctcagaccc tgtagcaatt    38940

cttttccccc cataataact ttctgcctcc cactctaaaa tttgcactgc aactttcctc    39000

gccacgcttc ctcccaccac cttcctgccc cttgaaagtc cttttacccc aaatatgccc    39060

tttctatagg tctgacagat aatatctgct gtgtgggagg gtggctccac actaacagtg    39120

tggaaaaggg gatcaacatg gctatttttt tatgctttat acctctcact tccctctcaa    39180

tctcttttcc tgtgctaagc cgaaggatat tttacttttt tgcaatacca tctctccaac    39240

cctcagattt atgtgtgcat atacaaacac agacacactt gcatgcacac tgacctcatg    39300

acacatccac acttcagcat ttatctgcat ctgtgccctc ctctttcttg ctttgcccct    39360

tttgagcagc acctggcata catggggcac agttcagaca atcacagaac aggatgaatc    39420

acagcttcca tggaaatgtc aatgacactg aattgggctt taatttcccc cattctgtca    39480

gccccacaca gattagcact tggatgtcca ataattggta tgtgtgcttg tctctccagt    39540

gatgcttact ttcaaaggga aaaaagagga gctgtaactt gttcattcaa caatactagg    39600

tgcttggtat aaagagatga ctagaacatg ttcttttccc taaggatttc catttgggtg    39660

gaggaggcag atataaacac agctatgtgt taaatagtgt attagagaca catacatggt    39720

gttttgagaa tcagggaaga aacatccact cttatggggc tggataggta tcagaaaagg    39780

cttcctggag gaaggcataa ttgggatcaa caataaatag catgtagggg ttcttctagt    39840

aattgaagac ttgagagagt ttggggagga gtattttcct ggcagaaaga acaacatgta    39900

tgtgcaaaga cagggaggca ccatttaagt acttctttaa tgctaattga tttattggag    39960

cccactcagg aaggcatcct ctccctcttt tcccaggtac attcatgtgg taaatagacc    40020

taatgcagtt tttatctaaa gccattttat aaccaataga aattaaatag aggaatatat    40080

agaagagacc caggagggtt tttgtggaaa atcacagacc agttggtctc gttagaggat    40140

gaattttaaa gcaattctaa tgcttatact cagaagacat tgcccaccat ttgtcaaaac    40200

cttaattcta aaataactcg tggccaagga gacactgctg tcaaatatgc aaccaaaatt    40260

ttcttctcag tttcttcatt ggtttgcttg gtgctcaagt gcaaataatg tagtattccc    40320

ttccttaata tggatgtgtc aatttttctc atttgcttca aaaattggaa ggatttttgc    40380

attttatgag ttctatagtc cttgggcatg tattacaggc agagagtact ctatttataa    40440

tactgagctt ttaataatgg ttgctaaaca ggatcaggct tcaaattatc aagagaggaa    40500

acttcagttc tgtgagataa ggggattagt aaggagaacc ccaattggca agattctcca    40560

ctttagtagc ttagtaataa aaaggagtta aggaaggtga gtggaataaa tcggtatgat    40620

cagagtttgg tatgaagtca atgtttagat tttgtacata ctatagacca cctgaggaca    40680

caaatgatgg tttattatgg tcaagtttca ctatggtcat gggaactacc taacccagca    40740

cactaattct ctgagggctc tgggtttatg aattagctct tttctctggc aactttaagc    40800

cacacagttc cctcaatgga agattttgat gggaaatgtt tattgatttg gaggaatgac    40860

attattcttc caggaaatta ggctgcaacc cttccttcag tctctccatt gttgactgtt    40920

caagcctcga gggatcctag aaactcattg cactgtacag ctcttgtctc ctcctttgca    40980

acacaaactc tcacattcat acagatggga tctaatgaat tgtactacct aattttcaga    41040

caatgaagtg cacttattca ttcaacaacc acttaccaag tatgttccag tactggtgtg    41100

catagtagcc tccttaggtc acaactttgc atgtggaaaa gtgaacttag gacagctttg    41160

tctagccctg tggccaaagg ttggcaatca actgaactat ccaggtgaca aggtttcctc    41220

tgacatgttc ctgaccatga taacctattt gctgagcatc agcacgctgt aatctctcct    41280

ctctcctggt ctttcccgga gtctatctag agtctccttt tttctttttc cccaccatgc    41340

atacctagaa taccccttag atttgtgcct ttacttagtg actgaaaggt cataaagaca    41400

ggggcaggga aatgggagta ggtagaggga agtgttgggc tctagatttc ccagaggacc    41460

agtttccagc cttcttgctc ctttggggca atgcccagtc ttttctaggc ctcgcctctg    41520

gaaaacgccg ggctagtcat ggcagtgtgt tccatttccg gtcccctggc cgagatatct    41580

cactccctga gggagtcaca gatgatggag tctttcctgg agaccacgaa agccatcggg    41640

gctctctgct gctgggtggg ggtgctggcc agcaaggccc cctccctaga agccctcttc    41700

ctcaacccag caaccctgac tccaggcatg gagaagatga acaccaaccg ccgcccacta    41760

gtgagcttgc ccctggagct gtcgatgtct cggtgagttt gtgaatgctt cagactccct    41820

caggctgtct tccacctaga agccttgagc caagaagcct gagtatcacc aatggaaggg    41880

atctttagcc atcatcctgt ccaatgcctc cccattctac tcctttttta cagacataga    41940

agatgagacc cagagagaga gagagattga gttggcctga ggtcaaacag gtttcctggt    42000

ttattctgca gtagtgatgc aaattatatt ccatttgacc ccatatttct tatcagtgct    42060

tctctgtccc cactcaacat cactgcctca gtgataggcc tgctttcttg ttggacaggt    42120

atgagaaaaa ctgaaggacc cttctcttcc tgcttatggc tctatgcaaa ctcttctagg    42180

ctgggcaaat ggcacccaga gaaattcagg aagtttctta ggacagatct gaatagaagc    42240

acagtattcc ttgctttact cacagaagaa ataatttgcc aaaatgagca aattaggcaa    42300

cagtgactaa ctggccagca ctctttaata gaataatcgc agagtgtaat ggcaagtcag    42360

ggattcctca ttggattggg agctgtgagt taatgtgagc tctcccctcc agtttcagca    42420

atgatgtttc tagtgttttt catttgccct ctctggctag ccagggatac agcgcaattg    42480

cagacagaat tgtaaagaga ccaataaatg gttccactga tacagataag tcttagagtt    42540

gccttagctc agtctctgac tcaatgtcat gtgattcagg gtcccagcaa gaaacagatg    42600

gaccactccg atgggctaat agagagagtt tagtaaagta tttacagagg tgtgggctgg    42660

gcttagggaa tgaataaggg acagtgaggc acctagaaac tagtaacagg gggaagctgt    42720

tacatgccta ggctgaaggg atgaaggaaa ggaccagaat tagactacag cagcagctgc    42780

cctcatgtgt cagagaggct gcctggcaga acttgtgatc ttagtagagg atcacagctc    42840

tgctactcag ccatagcaca ggagagaaga agccagggga aaatacctga cttgtctctc    42900

cttctatcct tgaatgtcct gcctatgtct cccattaacc aaacctggcc agaaccagag    42960

ggtaaggata acacattttg tacaggtctc cctccccagg aacagagaca gtggagaagg    43020

tagagagtag gtctccaggg caaatggaat caccaaaaca gagccttaaa gtcaaaggca    43080

tcctgcaggg ctcgctggga gtgcattagc actctagaaa atgcctcact gaaggcattt    43140

atgcctctct tgtgatgggc ccccaccctc ctttctctgt tcctgagatt atcatgtgtc    43200

tagatattct gaccttgatt cattctagtt aaattaccag gctagtgaaa gattgactct    43260

ttaggccctt ctgtttagta tggacctata ttttagtccc aactgtgcca gttaccacct    43320

gagtcacatt tagcaagtcc tttaaattat ccaagcctcc ttatctcccc ttgtaaaaag    43380

gtttctaaat agctggaggg ttaaatgaaa taacaaagtg cctacatttt tatacatgtc    43440

tgacagataa caataaatag tgactactag tatcatttgc ttagtcctca tggttggaag    43500

ctttataaac tttctttatg tttattaact gtttatactt acagtattca gcaataacat    43560

gctgtacaga tttgtagcct aggagcaata ggccacacta tttagcctag atgtatagaa    43620

ggctatagca tttgtttgtg taaatacaat gtaggatatt cacagaatga tgaaatcacc    43680

taatgatgta tttgtcagaa catatctcta tctgtaagtg acatatgact atatatgaga    43740

ttggccaata agaggctgaa tgatccaact ttgccatgaa gatgtcaggt taaaggagcg    43800

tcctgactct gtttgtgtct caacaggcat tcgatgcagg acaaaagaag actttcttgt    43860

cagcagaata cttagatgaa cctttccggg cccaaagggc aatgagtgtt gtcagtatca    43920

taacctccgt ccttgagggt aagtgctgct cactgcattg ttcatccact gtgtcatgat    43980

gaattcccat gtgagcagca gaagcaatgt ctctaactcg tgtcaaagcg tccatctctg    44040

tgtactggaa ttcctaatac tcctcattct tatgtcttag gccccaccat cttttatcaa    44100

tgtggttttt tagatgcata atttttcaaa aacaaaataa tttgatgaat aaaatatcct    44160

agctcatctc ttgttcaaat tagcatctgc tttgcatgca tcacaaaact agatttttaa    44220

aagtgatctg gcaggcatca gagaatttca ggccagctct ccggtgtaca agaaatttaa    44280

ccatccttaa ttttccaaca tggcaaaatt atccttttca tggtttcata attatatttt    44340

tcatggttgt aacttacaca gttgtaattt aatttcttgt tcaagcccac attatgctga    44400

atattggtag acaatttaag tccattaatc agtcaattta actaagtcct tgttaattta    44460

gaattctacc aatcaagtgg gaatccactc agtctcccca gcaatgtatc taagttccaa    44520

gccaaagggt agaggaagag agtggcaatg gtcatggcca cctatccaca cactttgcca    44580

tagagcgtga ttgcatccct ctaaccttga gcaggaggtc tgttctaatc cagccttttt    44640

ttgccttagg gtatggagaa tgcaaccttc atcatttcca gttatcttac tcccctagac    44700

aaattaaact gacctaggct ggaggagttg taagggagct tgagtgctgg tgtgcccctg    44760

agaaggagtc ctgtgtgttt tcctcccagc cctaggctga atcctaattt gaggggaaga    44820

agtggtgagc aatagaaacc aaaaaaatgt ttgagggatt tcaaaacaga gccaatgtgt    44880

gccctacttt ctaggtaaag ccagaggtgg caagccttag agagagattc acatgcacag    44940

aaactgtaga gtagaactag ccagtaattt accagatatg cagagatgta tctgttttgc    45000

tcacagctgg atctccatta cctagaagag cagtgcatta acaaaggtga tatctggggg    45060

gtgatgctac tttatagtgg tgtaaactga taaaaaggaa gaaaataagg aatagtcagg    45120

tatcttgggg taggatagac ttccgctcaa ggaagatact gtgagagtag agtaagaaag    45180

gcaggagaaa caaagacgtt tttaagaaaa tctggggaaa ggcaacctta gcttaggtca    45240

accttaggtt agagaaggcc tgaagcagcc tcagagagag ccctgtggct ccagaatggc    45300

agagaggagc tgggtgatga cttagccccc agtgaaggct atggaaaaag atgagtgaga    45360

cccatagagg gaaactagag agagaagagc catcttcatg gactctccca ccagggacca    45420

gatgggagct acaactcagg caaaatacgc ttagcaatga caaaggacca gctcaactct    45480

cctccaggtt tgagccctac aaaactcaga cacagactca gatattgaaa tagtacccaa    45540

cattgactta acaagagaca gttcccatgg tgaggacttg aagcataaat tgaattcaac    45600

taagttacat ttcttgcata cctgagtttg tgctttgaga aatgtgtact catttctcaa    45660

caacaacgtg tacagactct cttctattat tttttctcat tgataattat ttaatatcac    45720

tgttcattgt aatagagtct gtacttctaa catttttcat ggcatagaat ttgaccaagc    45780

tgctattccc acaatttctt tcttggccag ataggtttct tggtttttgt ttgtttgttt    45840

tggtttttgt tttgctatta gtcatcaaac agcaaacatt gaatacaaac agtttgtttt    45900

tttcatttat tctcgaaaac tgttaagctt cctccttctc tcttctttca tttattctct    45960

tatcaacaag catttgttga gcccctgttg tgtgtgtggc attgcttcag gtgctgggat    46020

tcagtggtga actgatataa gcttgcgctc atggaatcta catcctagca gggaagggga    46080

catgaaagat gaatagatat tcagatataa gaagtaggag aaaaaataaa gtaggaaagg    46140

agatggaaaa ttctctccaa gaagaacaga aatttgaatt aaataaagga atcagctatg    46200

taagaagctg aggagaaagt tcgcagacac aaatagcaag tacaatgcat tctgcaagaa    46260

tgagatagca acaagcaaaa tgcatgtccc aaacacatcc cagtgtaggt aagacaaaag    46320

aaggtcatgg gatgaatgag aggcaacaga gggtagtagt tagaacactg ctctggaacc    46380

cggctgcctg ggtttgcatc ctagctcttc cacttatggt acacagtgtg accttggagc    46440

ttcagtaact tttctgtgcc tcagattttt agcctgtaaa gtagtgagaa tatacttatc    46500

ttgtagagtt ttgtgaggat taaatgagtc aggtcaagca aaatgcttag aaccacgact    46560

ggcatgtagt aaatactcat cacatttggc tattatgatt tactaggttg taaaatctat    46620

gagggcggag atgtgtctgt tttgctcaca gcctgacctc cattacccag aagacaagtg    46680

catgcacaaa ggtgatattt gggtggttgg cggcgggagt gatgctaatt tataacagtg    46740

tgaactgata aaaaggaaga aaataagtaa taggcaaata tgttggggta gggtagactt    46800

cccctcaagg aagatgctgt gacagtagag taagaaaggc cagagaaaca atgatgtttt    46860

aaagaaaatc tgaggagagg aaaccttagg ttaaataaaa gaggtcaaag ttttctgagc    46920

atagggcaca tcatcttctc tggttggatg ttatattcat tacacacatg agacacctga    46980

aggatgcttc atgctgccag agtcgtaata ggatttataa aggccacctc tttaagaggg    47040

attatgctta agaaagtttg gcccaaacca acaggagttt gacaattcac tgaactcaaa    47100

gcatgtgaac cttctatgct tggcatgcaa gctgagattt cactgttgtc caagccagaa    47160

ttccagaagc tgggtcacag cagtgagctt actggagtgg tgagtgcctt aaagaggaag    47220

tgcaggatac taagtgaaat atggtaagat ttgcctggag ccagggaatt atcccaggct    47280

gaaaggactg caaagcagaa gagagaataa catttgaagg aatgaaaaag cctaatgtag    47340

ctgtaaccta gagaaccagg agaactgaaa ataaggctag agggatgagt tggggccaga    47400

tcccaagaaa ctcctagact gcattaagga tatgggactt catgctaaga ggagtgaggt    47460

gccattaaag gattggaggc agggaagtta catttgcatt ttataaaagt tactctggat    47520

acttgtagat ataagagggg aagtatgttg tcagggaaac cagttaggag gaagccaagt    47580

acaagatggc agtgcttgaa ctctggggta gtgacagtgg ggctgatggg aaatggaagg    47640

atatgagagc tatctaaggg gcataagatt caggacttga tgatgcatat ggttctggta    47700

taagtgcctt aagatatgct gatacaataa ctcataaagg gagcatttta ggggaagaag    47760

ggggctttaa tggggaaaga tgaaagaaga ttatgagttg agtctgggat atattgggtt    47820

tcaggtgccc ttggagcatc taggtagggg tgtccagtag gaagttgact ttaggatata    47880

ggggtctaga acttagatga caaagatggc atatatatat atatatatat atatatatat    47940

atatatacac atacacacac atatatatat gtatatatat atatttgaaa gcagtttgaa    48000

tgtaagtggt aattttgaaa agatgcaact ggatgagtta acacagaagg gttgaagtaa    48060

gaagagaaga aggcctcaga cacagttcta acaaactaaa tgtttaatag ttaagcagaa    48120

gagatggacc cagcagagga gactgaaaag gaaggtacag aaataggaaa agatctagaa    48180

gaatacaatg cagagccaag agtaaaaatt tcttcagaaa gaatagaaag gccaacagag    48240

gcaatgctgt ggaaaggtca ggtaaaatga aacatgaaaa ggtccagggg ctttagtcac    48300

atggatgtct ttggtgatct aagcaaaaga ggattaatgg agtaaaaggg taggcagagg    48360

tcatattgaa ggggcttaaa gagcgggtga gaggtgaaga aatggagata tggtgtacag    48420

acaatttttt caagaagttt gcctgtgagg aaaaggagat agtaagatgg cactagggag    48480

tagggagaat tgaaagaaga ctttttggtt tttgtgtttg ggggagtttt tgtttgtttg    48540

tttgttttga gcatatttgc atgctaatgg gaaggatctg ggagaataag agagactgaa    48600

gattaaggga agaaagggta tattcaacag actcctgcag tggcaggaga gaatgcacag    48660

tggagacact ggtgttaaca ggagcagggg gacctcttta agcgtaacag gatgaaggga    48720

ggaaagttct ctctgttatc aattttatat aggagatcct tttgaggtgg ggccatggtc    48780

atgttttaag ctggcaagta gatactttta gtctctgtgt ctctgcaatc aatcaagttc    48840

aacaatgtca aggctgttta caaagatgcc tctcttttcc catcatgcct cacaggtggc    48900

tgcttcctgc caaaatggca catctaaagt gtcctcattc atgactactt cctgtgcttc    48960

tttttagtgc caaaataggt ccagggaagt tcttgctttt gttccaaaca gggattgttg    49020

attttggtcc caggatgtgc caacttcttt agagaactat gctttgccag tttggacatc    49080

tgtagtttct aaaatccagt cagtgattaa aacagcatga cagtgaaaat aaatagtctg    49140

atctgtggaa gagaaatgga catgtgtata tgaaaacaca tgaacataaa tggtaataac    49200

atgacaaaaa tgacatttca aatcttggga aaatgaaaaa ttattcaata agtaatgttg    49260

atataaataa tcagagacag gaaaaaataa accacatcaa tatcttactc tttacccaaa    49320

ataaatttca aatgcaccaa agttttaagt gaaaaaagtg aaactacaaa agaaagaaaa    49380

aaacatggag aaggtatttt ccaagccttg tagtgagaaa agcttcatat gtaaggcatg    49440

tatgcatatg tggctaacct gcataatgtg cacatttacc ctaaaactta aagtataatt    49500

taaaaaaaga aaaaaattta aaataaaaaa atgaagaaaa ttgaaaaaaa aagaaaacaa    49560

ataaaaatac tactgataaa tcttgactac atacacattt ttaaattatc aggaaaaaac    49620

actgttagca aaatttgggg gcacacagtt atttctctaa actgattttt caagtgcata    49680

tagtaaaaaa aaccctaaac actgcaagtg tgtatgcaat gacaactatg tctccttccc    49740

actatagacc cttcctgctc cccagactcc tggtgcaccc ccctcccact ccagtttatc    49800

ttatattctt caagcaatgt tctatgcata tataagcaca tgcatgcaca tacacacact    49860

acacatacat atttttctac atcaccacaa ataaatctgc ctcattcttt ttcacaatgt    49920

attatgcttt atcagttgtt gttttccatt attattataa acaatggaca tcatctttct    49980

ttgcccacat aggctgatat ctgttcaaga tgcatgtctt gccgaggaat ttatagataa    50040

acctaaagct aagaaattgc cctccatcga ggtgaacaca gttacacatc cacatggaga    50100

tttaacggag gcaggtagag agataagcct agtgttcagg aagggatcag aaattggaca    50160

cataatttgg tgggaattgg catagagatg gttttttagg gctatgagat tcaaaaacac    50220

agagaagcta aggtgagaat gcttgagtta ttcaacattt acaagcagga aaggaaaagg    50280

gagacaaaaa cagaaagtga aaagaagtgg agaaatatgg gagaaaaagc aagagatgat    50340

gcagtcccca gagccaaatg aacactggtt tcaaagagaa caatataaat tctgtcaaat    50400

gttataaggg taagatgaga actggaaatc aattatttga atttggaagc agttaaagtc    50460

agattccagg ggctgcagag aaaaaaagag gtaaggagct gtagaaggtt aagtgtagaa    50520

aactcttgca aggaatttta ctgtcaaaga agcagtaatg aaagagagca tggggtccag    50580

agagactttt tcaaagccgc gagataatta aagcatgttt acctgctcat ggcaatggtc    50640

tggaagggag acaggtctgg atgatgcagg ccttgaatag gtgggagagg aaagagcccg    50700

gcacaagtgg gaggggtaga gccacccacg cactgtgtgg ggcacgaaga cagaatacca    50760

ggtggacttg cagatatgcc agagatttag tggtaggaag aaggggaagt tcttttgtga    50820

actagtctat attctgagtg aaataaaagg gagctcatca acagagagta agtagaaaga    50880

agagccggag gttagacggg ggaagaggaa gtgagaaaca gtcatctgga agaatgaagg    50940

aatggaatat aatatagaaa cacagccaga tttctgggca gggcaaggct ggggctcaca    51000

gatctctagg agggttggta agcatagttg tgtatttttt ccagccaggt ccagctggtt    51060

gggtgcaagt acagagtagt ctacaaattg ggtctattca cagttcaggt tttgccaggc    51120

aagtacaatg aaggaggaga ggggcaaagg aattgagggt gcctacaagg gagtagttag    51180

agagatggat gtgaaatcta agctgggcaa attgagaagt aaggacatga tataggtgat    51240

gggcagtaaa aatatgtaat gtcagcagtt taaaggactg gatggggcag atattaattg    51300

gagttgcagg actaaaggag ttcaaaatat aggaaatgaa taccagagac agagagaggg    51360

ctgaagtcaa aatgttggag gtggtactta ttattaacaa caaggtctag aggatgaccg    51420

cagaattggg gtccaaggtg acacatggct gacagctgtc attgaccaca ctataatgca    51480

gaactcgagg agtctgaaca gaagtgccca ccctgcttga ccagcttgtc tcagaagtat    51540

ctgatctggg attgctgccc catgtgggtg aagctcaaga caattctctt tgggcttgtg    51600

acggatccct ttgcagagct caccatcacc ttgtgcatcg tggtgaacac catcttcatg    51660

gccatggagc accatggcat gagccctacc ttcgaagcca tgctccagat aggcaacatc    51720

gtgagtgctc tggctggtac tgccctcact ggcgtggtcg gggcggggtg gggatgatgg    51780

cagggtgcag ttcgggtggg gtggggcatg cccttattgg ttagtgtgtt gagccagtta    51840

gctgagagca gagcagcagt gcaggagaca tgtggacact gggttcagga ggtcaagtgt    51900

gggaggaccc aggctgagct ggtgggaatg gctttgggat gaacaagcac aggaaagtga    51960

accaggagag cctggagcca gaggcagcta gttgcccttt acaaaacata ggacaaccac    52020

ttgaattttc tggatctcag ttgcctctac cttgaaatga ggataaatgt cactttttta    52080

tctaaagaca atctttggac ttgtctgttt ccttccaatg taattacttt tatgaccaca    52140

attaacagta gccacgattt tcaatgttgt cacttaagga gaaaaagagt tggggaggga    52200

aggggaagac agtggaaggg aggaaacatg gaaacaaggt tgctgttgta acaaaagcat    52260

caggaagtcg gaacttttct ttggcatcta gtttagacat catgctgctt taaattttcc    52320

tccatcactt gttagtatta tttactctta acaagataca atccatactg gatttcacta    52380

tatactggat aaagtatctg actcagaggg acaacaactg ctccaacctt gccccaccca    52440

caggaatagt aataatactc agatgcttct catggattat ctcattttat tttcacaaca    52500

accctacatg gtaggcactc ttgttattcc ctttcccaga tggaaaaatg gagatgcaaa    52560

aggttaaata atcttcccaa gatcatagag ttgagtttag tggccacatc agaatttgaa    52620

cccagacaga ccggctgcca agcccgcttt tcttaacccc tgaattaagc cacctcacaa    52680

gacttgcgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg ttcaaacaca cgcacacatg    52740

ataggcagaa gctagaaagg gtcagcatcc tgccttcatg tccgcagcag ggtccaccaa    52800

gctggaggtg acctactgga ttcaccagaa ctgtctggct ttggggtcca gcttcttata    52860

ggctgcagac ttaggtggag ggggaaggcc cagaggaaat gtgactactt gtccctagaa    52920

accactccct ccgccataat ccagggctgt gaaaggggca gcagtaggtt ctggaacatg    52980

gtggaatcag catgcctcat gttttggcag cacctaggct gaggtcacat cctaaagttg    53040

atatgaaaag gaaaaatgga aagagaagag aatgcttatt cccaagaagt cagcctaaga    53100

ccacagaggg ccttatggaa tagacatttg agcccacacc ctcattctac agttagaaaa    53160

gtggaagcaa gagagagaaa aggcctttcc cacagtgtca gaggaaagtg ccactttttt    53220

aaagcaagaa agtcatgtgc ttggtgcctg caatgagtca ggtgctttat gaatgttatt    53280

tcagtgtcac aacaacatta tgaggttaac atcaccctca catgacaaaa gagagcacta    53340

agactcagag aggttaaata tcctgcccaa aattgtatag ctggtgaggg tggatccagg    53400

gtggacccag gtctctggaa gacacaagac ctcaacccta ccccccacca caccacactg    53460

acttgcctac aagggacact ccatagatac tctttgaatc agtcttgtgg catgagaaag    53520

tcacttaaac tctcagcctg ttttcttctc cataagaagg atgcattgtc tgtttctcag    53580

gctggtgagg ggctcagata aaaagatatg aaggaaaagc acctgaccct ggtcgttgct    53640

ttcctccttc tctgtctccc ttccctgctg gttgttgtgt tacccgagcc tggttctgac    53700

ctctctcagt gtcagaattc tgtcctattt aagacaatta gagacacaca gagcctaaaa    53760

gaatcttaga ggcaatgaat cattgttctt actagtcact gttacttatg aatgaattac    53820

tgtctgccag gccctttgtt aagaactgca catgcattgg ctcattttat gcccattata    53880

cagatgagga aattgaggta caggaaggat gcattatttg tccaagctta cataagctag    53940

gaaatgtctg ggctgggatt ttaatccagg tctgtgatgt cccacaaccc acacgtttta    54000

actactgaac cagactgact cttcactgac aaaatgatat tataataatg atcttaaaga    54060

ctatccgctt attccactcc caccaccatt cacgtggaaa aactgcagca tgcacagccc    54120

ctgagaatgg tgcagaaatg tctccattct gtcacgttga ctgttaccct ggccaatcct    54180

caggagccca cagataacat agcaactgaa caaaacaaaa ggattttcta ttttgtaaat    54240

aagacatttt cttgctgcca tttttatcat tgcctccgac cccacagatc ccactgtgat    54300

gaaagcttgt ttccactcct aggtctttac catatttttt actgctgaaa tggtcttcaa    54360

aatcattgcc ttcgacccat actattattt ccagaagaag tggaatatct ttgactgcat    54420

catcgtcact gtgagtctgc tagagctggg cgtggccaag aagggaagcc tgtctgtgct    54480

gcggagcttc cgcttggtaa tgtttttctc ttgatggctt ggggaaactc ccacccagat    54540

tcagggaaga cactgtgctc tggggactgc accagccagc tcccccttcc tctcctgtcc    54600

ttgtgggagg gagcagggtc tgactcctgg gcgactggag acttgggtct gtggccccag    54660

cttttcgctg actcagagtg gggacatgcc ttctcctttc tgggccttgg ctcccttatc    54720

tgcaccaaga ggggacttcc aagcactgtc ctcgtctctt atcaaataac aataacagca    54780

ataatcacag cagctaatac ttactgagca cttacaatgt gtcaggcata gcactggaca    54840

cttgaaaaaa cgcacctcat tttatgctca caacaaccct gagagatagt cgtttttaag    54900

atcctcaggg gtgggtgagg aaaaagaatg gttccatgat gacccgaaag tctcccatct    54960

gccaagcaag cgaataagcc acagacctgg atctcaaatc caggttgtct gactccagag    55020

ccccagctcc ttccagcctc aaggaagtca ttctctgatt cccttgtgcc cgaaatcaca    55080

gccccaatgt ctcaagcacc ttcaacctgc ctattagtct cactcacatg caatgatggc    55140

tcttctctaa actcagctcc aggacgccct ctacaggaga agtgccacag gccacccact    55200

tttatcagag ccacaggttt gtcagccaaa cctgtcagat tcccaggagt gtcgggtcac    55260

taggtctcca ggccatctgg aggaagcttg gcatctcact gactcttggg aataggaaag    55320

aggcctgaag aaatgtcacg gcttgttagc gcaggccgcc tgctctcagg aatctctcag    55380

tattaactgg gagccctgca tctagacttg aagagaggtg acaaaacaaa ggggagtatc    55440

caacaatctt cccaaggtcc tgacaagtgt tggcatccag aggttgaagg gggtgcatgg    55500

ttcaggaggc aacgagactc taggacagat ctgcttggga ccctatcaca ggggccagtg    55560

agacagtgct gagcccctga acttggcgta cctggattag gggtggcaaa ctcaaatgcc    55620

catgtgcagt gacatagagc cagccatgga agagatgtgg gcactggata tttgcctcag    55680

gtagacaggc aaagatgact ccatttcacc taggcagacc caaagcagtg cacaactcct    55740

gggagggatg tttacataga aatcaatgtg accatctcag gccaggtgca gtggctcaca    55800

cctgtaatcc tagtactttg ggaggccgag gcaggcagat cgcttgagcc caggagttca    55860

agggcaacat ggtgaaaccc cgtctctaca aaaaatgaaa aaattagcca ggcatggtgg    55920

tgcacatctg ttatcctagc tactcagaag actgaggtgg gaggatcacc tgagaccagg    55980

gaggtggagg ctgcagtgca ccatgatcgt gccactgcac tccagcctgg gagacagagt    56040

aagaacctgt ctcaaaaaag aaaggagaca cagagagaga ggaataaaga tagaaaaagc    56100

gagagaaaga cagatgaaag aaagagagag agcaagaggg agagagaaag aaaaagagaa    56160

agaaagaaag aagaaagaga aagaaagaaa gaaagaaaga aagaaagaaa gaggaaggga    56220

gggagggagg gagagagaga gggagggagg gagggagaga gagagggagg gagggaggga    56280

aggacgagct atggcctgtc cattattgtc agagttacta attttccaaa aaagtcagaa    56340

atccagattt ttgtgcaaat gtctttaata ttggctacta atccagtttt taaaaacact    56400

ctaaagacca aataaagcat gtcctgagac acagctgtgc catgaaacgc tggttgatgg    56460

catctgccta agctgatggt actgtcacca tcccagggag gagaagggta gagtaggcct    56520

ggtaggactc tttatccata acttgaaaat cttacaaggt cagaattaaa tcacattttt    56580

agaaggacag atttctctag gtatctagaa attgatgtca agatgtaggc ccctaagcta    56640

atggtcaata taaggtacct atgcacaatc gtcaagagag caggagatat cacaccccca    56700

taccctggca ggcccacagt tagttttcta ataaaatacg aggctgggcg cggtggctca    56760

cgcctgtaat cccagcactt tgggaggccg aggcaggcgg atcacaaggt caggagatcg    56820

agaccatctt ggctaacacg gtgaaacccc gtctctacta aaaatacaaa aaattagccg    56880

ggcacggtgg cgggcgcctg tagtcccagc tactcgggag gctgaggcag gagaatggcg    56940

tgaacctggg aggcggagct tacagtgagc cgagattgcg ccactgcaat ccggcctggg    57000

ctaaacagcg ggactccgtc tcaaaaaaaa aaaaaaaaaa aaaaaaacga acatttctgc    57060

tacacttggg gaagcagaag cttagtgttt taaggtctat gtgctacttt tgttctgatc    57120

ccacagtcta aagtcccaaa caaccaaaaa taggcaagtt tacttcacag tctgccccta    57180

caggattctg caggggaatg ctaccctgtc cccacctcgc tgatttaaca tgctgatcag    57240

tgctcaattc cctaaccaca cccaccaact acacactttc ttgggatcta ttccacttcc    57300

ctcatgacct agcttagatt tcacagccca ccaatattat tatgcccttg aaaacaaact    57360

caatcacctt ttccctctgc ctctttgcgt ttttgtgttt gccaaaacct caccggagag    57420

tctaagtcaa atatttctct ccaccttgtc tgcacctgag ctgtgagaaa tgctggagaa    57480

aaatcaccgc cagctggtca gtttcctggt tttaattaat agactttatt ttcaggacag    57540

ttttcagttt tcagaaaact ggagcagatt gaacagaaag ctttcatata ccatcaatcc    57600

cacaacacac acacacacac acacacacac acacacacac acacacacag agtttcccta    57660

ttaccaacat cttatgttag tacctacatt tgttacaaat aacttcactg gtttcccatt    57720

gctctgagaa taaaatccag actcctcatg atggtgtaca aagttctgca taatcaggac    57780

ctgccagttc accagtctcc gtcttgccca ctttgctcca gccaaaaagg cctactctct    57840

cttcttcaca cataacagag aacttcttgg ctttgggcct ttgaagtttt tttcgctgtg    57900

cctggaatac ttttccttta gtcttcactt agctcactta ttctcaaact ctgtgttcaa    57960

tgcacttgtc acctccttag aggggacctc cccaaccaca ctatctaaag ttggattcct    58020

tcatcaaatt aacctggcat ttacaattgt cctgctatcc catgaggcaa aaaccagagt    58080

ttcttgtcta ccgttttatc ccaagggcct agcacaaggc ccagcacata cataggaact    58140

caataaacac ctgttgattg attgaaggaa ggaaagaaag agaggaaggt ggagggaaaa    58200

aggaagaaat aaaaagtctg tcttccttct ctcccaaaat agcattgctt ctcctcccgt    58260

cacttaaagc cttgctccat ttgctctgtt agtccattgg tctatcctgg caccaatatc    58320

agtcttaatt atggcagctt taaatatatc tgtgtctgta aatcaagtaa tccacctaat    58380

ttacttcaag aatatcttgg cctgcacact ttcatattca ctttagaatt atcttgccaa    58440

gttacatacc cacatacaca caaaactgct attgtttttc ccattaggga ctgctgtaat    58500

tgataggtca atttgggaag acttataatc tttacataat tcagtcttct gatctatgaa    58560

gatagtatac gctgtatacc agtctttcaa taaagtttaa aaatgtttcc atgaggtttt    58620

tataattttc tccataggat cttgcatatc ttcttaaatg ttcttttctg gcatttttgg    58680

ctagcatttt gatatttaac atttttgtat ctagaaatgt ctcttattaa ttctaataat    58740

ttatctatac aatgttttaa attttctaac ataatcacat catgtgaaaa taacaatgag    58800

tttaatttct tcttttcttt cttttttttt tttttttttt tgagacagag tctcgctctg    58860

tcacccaggc tagagtgcag tggcgtgatc tcggctcatt gccagctcca cctcccgggt    58920

tcacgccatt ctcctgcctc agcctcctga gtagctggga ctacaggcac ccaccaccat    58980

gcctggctaa ttctttgtat ttttagtaga gacggggttt caccgtgtta gccaggatgg    59040

tctcgatctc ctgacctcat gatctgcctg ccttggcctc ctaaagtgct gggattacag    59100

gcatgagcca cccacgccca gcctaatttc ttcttttcta atccttatgc cattaggttc    59160

tttttactag atcactgtgc tagttaggac atccagtaca ctgttgaaaa gaagtgttaa    59220

taacaggtat ctttatcaat tttctgatcc caaaaagaat cctttcaata tttcaccacc    59280

tctaacaatt gtggcaggct ttttttaaag ataagaaatc tttatcagtt caggaagttc    59340

tcttttatca agaatattta tcatgaatgg atgtttaatt ttatcagaca attattctac    59400

atgtattgag ataatcatgt attttctcct tcaatctgtt aaagtggtga attatattaa    59460

ttgattttct aatgttaaat caactttaca ttcccagctc aaacctagct tgatcgtgat    59520

gcatttttta atacattgga agatttagtt tgctaaaaat ttgcttaaga tttttttatc    59580

catatcaatg agtaatattt gatctataat tttcctgact ttcattgtcc ttgccaggtt    59640

ttggtatcaa ggttccaaga ttatgccatt ttttttttaa agccaagggg gccaggtggg    59700

gtggctcacg cctgtaatcc cagaattttg ggaggccaag gtgggaggat tgcttgagga    59760

caggagttgg agaccagcct ggccaacagg agaaaacccc atctctacta aaaatatata    59820

aattagctgg gtgtggtggc acacacctgt aatcccagct actcaggagg gtgaggcatg    59880

agaattgctt gaatcccaga gacagaggtt gcagtgagct gagatcatgc cactgcactc    59940

cagcctgggc aacagagcga gactccgtct cattgaaaac aataaaaaga aggccagggg    60000

cagtggttaa tgcctgtaat cccagcactg ttggaggcgc aggcaggcgg atcacctgag    60060

gtcgggagtt cgagaccagc ctgaccaaca tggagaagac ccatctctac caaaaataca    60120

aaattagcca ggtgtgatgg tgcatacttt taatcccagc tacttgggag gctgagggag    60180

gagaattgct tgaacccggg aggcggaggt tgcggtgagc tgagattgca ccattgcact    60240

ccagcctggg caacaagggc aaaactccat ctcaaaaata aataaataaa taaataaatt    60300

ttaaatttaa aaaagaaaag gaaagaaatt agctgggcat gatggcacgt gtctgtagtc    60360

tcagctattt gggaggctga ggtgggagga tgacttgagc ccaggaggtc gtggctgcag    60420

aaattacagc ataaattaac tctccattag ttaacttaat caaagccaaa agttagctaa    60480

aatctttaac cttcctccaa gacaactttt cattccagat atcctttccc aatttattgt    60540

aatgataagt attttaattt tatcttgttt ataaaaattt ttattaatca atgaaaaata    60600

aagctaccta ttatacagac aatctctaaa actgagtaac tgaccccaat aaaggtttat    60660

ttctcactcg tatcatagcc taatgcaagc cagacagctc taggtgggac tccaagaagt    60720

gactttgcca tgcctgaagg aggccaatat aacttcaaag tttgcctcct gcttgtggga    60780

aaatggaaag ccaaggtttg ttttaaggtt taaacagtga aaggcttttt cagtcaggga    60840

ttttgattta tttcacaata caattacttc aaaaacttag atggcttcag acctctcatt    60900

gccacacaaa gtgctttctt tgacaaagtt ctcaattgtt ctttatttct ttgctttcct    60960

ttccccatgc ctttctcttg cacaagaaac agtggctaca ccattactac aagctttgct    61020

aagagttgtt tcatttaatt ggaaaattta actagtcttc aacatttgaa gacttaatcc    61080

cattgctcac tgcctggaat ctagaagcag tacagttccc taaatcgtca aggctctaaa    61140

cttctggatt atattttctt ttattcttat aaaccagcta aatctttcct gagctaatct    61200

ctttcttgta ctgtcttgac caacatagcc aattacaact gacccacaat actaaggttt    61260

aataaaccct tcccctaggg ttgctggttc atgaggctcg tgctctgcct caaaattttt    61320

gccagcaata tttttgtcac tgaataacat agattgacat tccaagcctt ctcctatcag    61380

cttccttgtt gcccaccaca tgatcattaa gccagtgcca catagttgat gcttttgaaa    61440

aggcaatacc ttttttcaat gaagcaattt ctccattact caagataagt acaactagct    61500

gcagtgatac cctctaaatc tgtgagttaa cataatagag atgtatgtct cacagcacat    61560

tcagtgcttg ttgggaagct ctcctgggag tgtctacttc aagtagcgcc tcaaggatct    61620

aggattatcc catatcgtga tgtcaccatc ttcagttagt gacctttatg gtgaacatga    61680

aagggaaaga aaaagttcag ggggtttaag gctatgccta aaagtcatgt atattacttc    61740

tgtctccatc tccattccac cagacagaac ccactaacat gaccccaact atttgcaagc    61800

aaaactggaa aacagtcttc cgttgtgtct gggaggagaa aagtgaatgg agactatatg    61860

accagtctct tccacatctc acaagacatt gttgttgtgt ccactcaatg tttatttaga    61920

ttcactctca tgcttagcac tttcttgctc tttatacctt tgttatagag ccagtggggg    61980

ctcactgccc aatgctctag aagccaatac tatgactttg gaagccaaga cgaggacacc    62040

aggcttttga gaaaagaaaa gcttaatact gcaagctggc tggcaagaag acaggaggtc    62100

aagctcagat ctgtctccct gtgctgtctt caaggcagta tttttattag aaaatgttta    62160

gtgggtggat accgggattt gcaggtgatt ggtggaagga aaggggaggt ttggagagtc    62220

catgggcctg cacagttatc tcttcatgct tactcatggg ttgcatatgc aaatctgggg    62280

ggagttagta tgcaatatga agtggaaatt cagtccatga cgtcagcaag ctcattctgc    62340

acaaactcca gtcggccatc ctggttccaa ttgatttcag cctgtttttt catcatcaca    62400

caaggggagg gagtttcagt gtctcagcaa gttgtttctt tacctatctg ctatcctaaa    62460

aactcaagaa tttttgtaag ttactgattt cttactcttt ggaacacagt ttgagtttca    62520

gattttcagt gagttatttc ttatctggta tcctgtaagc ctaaaaattt agttattgat    62580

ttcttcaacc ctttggagca cagtttcaca ttcttgtata ttacacatta catattactt    62640

ctgggatcac tttctatcta cctgaagtac ctcctttaga atttctttta gtaagtgcct    62700

tctggccata acctctttgt ttatctgaaa tttgctcttc agtttgcccg tgtctttgag    62760

agacatttct tatgaatgta aaattctagt tgatacttta tcttccttca gtgaagatag    62820

tattccaaca attagcctcc attgttgcta atgagcagtc agctttcaat ttaactgtta    62880

ttccttcctt tctggatgct ttttaaatct tctatccatc tttggtgttc tgcagtttca    62940

ctgtaatatg tctaggtgtg gacttctttc catttataat gcttaagata tactgacttc    63000

ttgaatcttt agttttgtaa ttttcttcaa ttctggaaag ttcccagaca tgatgtgggc    63060

agtcatagcc tccacgccat tctatttttt ctccttctgg actttggtta gatagatgtt    63120

aaactctctc attctatcct ctatgtctct tacactattt tgttattttt catcttatgt    63180

ctctctaggt tacattctga ataatttatt ctgatatatc ctcagttcac taattctctc    63240

ccaaactgtg tcaaatctga tgcaaacctt cttcataata tttttaattt taagtattat    63300

atttttcatt tctaagagtg tatttttcac aacttgttat tgttatctat agttttttta    63360

ttctctgcac atagtttcaa gttattattt tatttcttta acatattata tctaattata    63420

ctgttatctc tgactaataa ttctatcatc tgaagaaatg gaatgactat ttccacatct    63480

gtggtttctt caagatctca ttcactcttg atgactcatt ccttctgttt ttgtttgttt    63540

ttttactgca actcttaaac aatttttgag ggaatagttt gaaacctgag ataaaggcag    63600

gttcctccag aggtatttgc atttaattct gcagagcact ttgtagaatt gctctaaatt    63660

aaattctcaa cttaaaatac ctaggtagtg tgaattccag ataaaatcct atatgagcac    63720

cactttgttg tttcaaatgc tcagcgtcaa ttttcctcct gtagctggta cctaacacca    63780

gccattcaat tttccttgca ttctcctggg attgtttgtg gttcatcctt acatgaaggg    63840

tatagctctt tgggatctag tcttaaagca gggagaaatt cctgctaggc ttacaacctt    63900

cggcaggcca tggactacgt ttcctgctcc ccatactagt tactaatgct cagtttttat    63960

ttgtgtttat cagctgcctc tgtgaccagt ccacagagtt gttgttttaa gctctgcttc    64020

ccatatgagg agagtaactt ccagattggg tgtaaggtga acgtggaccc gctctccccc    64080

atcacataaa gaggtgcata cagcacttac tgtataacag gattaaacct cctcccgtgg    64140

gatttactca cggatatggg tgataaaatt gtagctacac tgttgtgttc agcattgcat    64200

cctagcacct aagccacagc ctggctctta gtaggtgctc cataaacaca ccttgactga    64260

cagactgaca gttgagctca gatttttttt cctgacaaat tagagaacca tacaaatata    64320

ttttaaaaca catacatttt tatgcttgat gattttgctg tcttgtggga cttagcatat    64380

ttgagtttac agtgaagact tttgagactt catcttttct cagtaactaa accattggtt    64440

ccatgagagc aagagcccac acacctctct tcatacacct cataggctag cacactgcca    64500

tgcacctgca cggctggagt tctggggggt aggttcgttg gtcaattaaa tcaacttatg    64560

aatgctgagt ccatgaaatc atggacattt gcagtttcaa agctggtggg agcaacagat    64620

gttgtccact gccccaagat gagaaatgcc ctaagagatg ttttgccaat acctatcgaa    64680

tgcagtgggt catcccctac ccgaaggagg ctggtctctc ttcagtcata aataagcttg    64740

ttctcactta tttgtgagcc ccatcacacc caccccacct ccacagaaga ggcccatatt    64800

caggagggat caggcctgtg gctatagaac agagtacaga tcgcaaggcc accaccccag    64860

tagaagaccc tgactcagcc acagtcaatg aagcacattg atacttatga accatagaag    64920

gcagatcata tttttgagta atttatagca taggaagaaa ggtctccaaa agcagtgtcc    64980

agaaaacgcc ctggtttaat gggatgagag gccttgtgtt tttcccagat ctttggtttc    65040

caggcaaaac tttagatgaa aggtaatgag cacagctacc aaaacctgac ggtctctgtt    65100

tctctgcagc tgcgcgtatt caagctggcc aaatcctggc ccaccttaaa cacactcatc    65160

aagatcatcg gaaactcagt gggggcactg gggaacctca ccatcatcct ggccatcatt    65220

gtctttgtct ttgctctggt tggcaagcag ctcctagggg aaaactaccg taacaaccga    65280

aaaaatatct ccgcgcccca tgaagactgg ccccgctggc acatgcacga cttcttccac    65340

tctttcctca ttgtcttccg tatcctctgt ggagagtgga ttgagaacat gtgggcctgc    65400

atggaagttg gccaaaaatc catatgcctc atccttttct tgacggtgat ggtgctaggg    65460

aacctggtgg tgagtggtga accctgctgg gggcactgtc tcctggggaa aggagaaggc    65520

ttctgggtta tctgaaaaag ctttgatctg catttttatg cccagattgt acttctctgg    65580

ttgaaaagtc ttcaaacttt tcaaattcat gtgggattca ttacaagaag tgtgccttgg    65640

gaggcagtct gacttgcagg aatgagaaca tatgattaga aaagaaagac ctggtgtaga    65700

atctctgctc caccatttac taggtgggtg accccaggca agagacttaa tctcctcaag    65760

atctaatttc cttaaaatca agaaaataat gcttactcat gggtttactg ggagaattaa    65820

atgacaggag atgacatatg caaattgcct aatgcaatgt ctgggctgag gcaggaactc    65880

aataaacggt gtctattagc tgttaaagga aaaatgtcct tccccaatct gagggggctc    65940

agaaaacatt tttattcagg gaagtaagag ctgactgatt tctccaagct gcacaggtcc    66000

tagctgggag cagggggaga ggctgcaggg agggggcaca atgggtcacg gacaacatcc    66060

aaggccacag aaataataac aaaatctact ccatgtttgg aggaagcccc tctggagact    66120

cacttgccaa taagccccaa taccccttct ccgccccagc ctggccccct gccctcagct    66180

tgtctccacc cactctggtc atggtggggt ccttgccctc ctgggactga ctggttgtgt    66240

gggaggatgc agtcttccag aagccccttt cttattgccc tggacatcaa ccaacttggg    66300

ttctttcctc atgagtttta tagacagaag aaagctaaac caagaaaagg gaagcaacaa    66360

caaatccaga ctctttagtc ttttccaccc tggtgcctga gccagggatg cctctgcctg    66420

catcccagaa actctgttct tccaggctga gcccaccatc cctgcagagc cacagatgcc    66480

cctcaccctc agacaggaag tttacccctc tgagcacttt tacatttctc atatcatttt    66540

gtcttcacaa ccgctcttca tctgctctca agtgaagaac tggaagcagc aagatgtgcc    66600

caggattcca gagtcaggaa cagagcccag ggctttggca catgagggtg gttgcaggaa    66660

gggctggtgc cttctctctg ttgtccctaa atgtccctct gctcagcggg gggctcctcc    66720

tttatggtgg aaaatatgct tccaagcctc gtccactgag gcgggtcact ccaggacatc    66780

cccaaacttt ccctcaactg ctctcagaaa gtccattccc ccaaaaggga cagcatcccg    66840

ggtgggcagg aagaggccca ggccgtggct gtcttgccag ccagctgcta acccggtagg    66900

ccaatgtggg gctcagctta gagattgatc aatcttccct tccattcctt ctcttcaggt    66960

gcttaacctg ttcatcgccc tgctattgaa ctctttcagt gctgacaacc tcacagcccc    67020

ggaggacgat ggggaggtga acaacctgca ggtggccctg gcacggatcc aggtctttgg    67080

ccatcgtacc aaacaggctc tttgcagctt cttcagcagg tcctgcccat tcccccagcc    67140

caaggcagag cctgagctgg tggtgaaact cccactctcc agctccaagg ctgagaacca    67200

cattgctgcc aacactgcca gggggagctc tggagggctc caagctccca gaggccccag    67260

ggatgagcac agtgacttca tcgctaatcc gactgtgtgg gtctctgtgc ccattgctga    67320

gggtgaatct gatcttgatg acttggagga tgatggtggg gaagatgctc agagcttcca    67380

gcaggaagtg atccccaaag gacaggtaag agttatcccc aagggacagc cacaggcagt    67440

ggggaggggc ttcagggctt gagtgacaaa gggcaaaagg gaaatgcaga ggagaccttg    67500

acataaagaa gtttaaacca tgccaagctt tccagaggag ttggcgtttg agcagggcct    67560

ggaagaaaaa gtcagaattc cccaggcaga caaacaggga gtggggggca gcaggtgagc    67620

aaaaggccac cttgaggtgc ttggggattg tctttcacac agctgtccca tgcgctctgc    67680

ccaacccagg ctctgtgcat gagatgctaa tgagatttct ctaagaacag gatgttgtcc    67740

aagagcaagg ctcatctaat ctttaccagc atcctaagaa gtcctgattc ttatgtgact    67800

catttagcca gcttttcccc acaagtggta tcacagggaa atgacacgct ccttttggca    67860

ccaactaatt taaagcacat ttgagccatt tgataatata tatttttaaa tacttggcac    67920

tattccttac taccttaagc tggtatatca accctcgcta acctcttctc agtaactcag    67980

ggcattcacc tctgcccaac gtgggaaggc agggaaccct gtgaggcctc aggaacatgc    68040

agggctgctg gccaggttac taagtggtcc agaaaagctg tgctttgagt ctgtagctct    68100

cccatagcct tcttccctgc agtcgtcact tgtgttccag cagctgctgt tatcagctgc    68160

catattttac atgcctttgt ctaggtaaca gcagagagca tgaactctgt gacagctgtc    68220

tgccactcag aagcattttc agttactttg gggctcttag ggagctccag gtggccaagt    68280

tccctacaat tttgacctct ggacaaataa caatggtcat ggctaaaatc tattgagcca    68340

agcacttcgt gcaaagtgtt ttacaagcgc taacatattt agtcatcaaa acagctgaat    68400

gatgcagatc tagccttttc aattttgaag ctgggaaaaa tgaagattag agaggttaaa    68460

caacttgcct aaggtcacac atcttataat taatggagcc caaggataaa acataggtct    68520

atctagctat agtcttcatg ctcacttcac acacgtgtat gtatatatgt atgtacatga    68580

gttgcatata tgaaactctt ggctctggca gcctgtgatg tgcaagatcc cttcaaattt    68640

agaactggtc atctaagggt ggggccaggc acccagttgg gaccctctct cactagcagg    68700

agcagctgca gcaagtcgag aggtgtgggg accacctgac acccaggagc ccaggcactg    68760

gaacatcttc tgaggacctg gctccatccc tgggtgagac gtggaaagat gagtctgttc    68820

ctcaggtccc tgctgaggta ggtatgtcag cttcctggag aggttggaca gccagccaga    68880

cactgagcag tgggctggta gaggctggag ggtggcggtg aaggtggggt attccagact    68940

gcactcaatc acataacctc atttcttatc ctgggaattt ttaaagtccc tcccaacctc    69000

cggctaatcc gcacaatttc aactttcacc atataccatt gccacaatct cactccaggg    69060

tggttctagg tatagaaaga aagagtgaga ctccacaagc tgtgggacct aagatcagtt    69120

cccaaacctc tctgagccgc catttattca tctatgaaac tgaatggtaa tgcctacttg    69180

gtaggattat tttgaagctt aaatgagatg ctgcttgtca aatgtttagg tcctgcctga    69240

gacaaagtaa gtgcccagga aatgacagcc aagaaaaaag gaaacgaaag acaacgcaca    69300

aagaaagtca aatatctttc agagccagca aataagagtt ggaggtgctc acagatgaag    69360

aagttttccc ttgtgattct cccccacttt cttttgtcca catcattttc tctaggcaaa    69420

agtagcctgg ggctagggag aggctctcta taggtgagta gtgaagtgac agcctcacag    69480

agactgagct ggaagattag aggtttagga ttgtcttata caaggtaaaa ataaatgtgg    69540

tttcacttac aaatcttgaa ggaaacaagc tatagggaaa gaggcatcta taaaagttta    69600

gcatctttaa taacactgcc ttcaattcaa gaatttaatt tgacacctag ccactgagtg    69660

ctgactttgt gacaggcact gggctcaaca gagataagga agtcataatt catccccaaa    69720

gttatcaagc ccttcagctt gaagaatgtc agctactggc tgtgtgccct aggcaaggct    69780

gaccacagca gggtaagata agagggaggg ctgggacggg atttgggggc tgtgggtgaa    69840

cagaagccgc ttggttccca ctgggtgagg gctgtcacat tctgcacgtg gatgtcatgc    69900

ttcttcccaa atgttccaag gactcccctg gctagttgtc cctactcaat gttttcagta    69960

cacaacttct gggtgttggt tttttgtttt tgttttcttg tccatgaccc cggctaggca    70020

ggaggggcct gacagcgaca aatggggacc cgccccacca tttgggtcca ttagcaaagc    70080

tatcaggttt actaatatga gagcaacttc aacccctaat tgaattcatc tggagacatt    70140

atagggctgg agctgccagg agggcagcag gcccctgcag cattactcca tgattaaata    70200

ttcaagccca gtgaatgctg agagtcgtta tgggtgtaat tacggtgtct cgggccattg    70260

ccagcactcc atcaggggcc ccgaaggttt acagtctcac acagctaagc ctctggggct    70320

ccagggagaa gagcagtgtt ccaggcctca gctggcgagg caccaaacat gggtgcagtt    70380

gaacctgcag tgaccgtgtg caattccccg ggccccgcgg agagacgagt tcactgccct    70440

gggcttctcc cctgcaggga gtggacgaca caagctcctc tgagggcagc acggtggact    70500

gcctagatcc tgaggaaatc ctgaggaaga tccctgagct ggcagatgac ctggaagaac    70560

cagatgactg cttcacagaa ggtgaaggga cagccacagg ccccctcaca ctgatgttaa    70620

ttagggccag aatccagttg agcgaacact cacctgggat ccacagaaga caaacaagct    70680

gtgcccactt gctgcctcac tcccaggctt gagggcgccc gcatcagaca cacatgcccc    70740

aggtggcagc agcctggccg tggtatctgc atctcatgcc ctatcagaca ctacggagag    70800

acgtgggcct tcctctttac cctcaaaaac ccctccgtga gttctaaacc agccctcttg    70860

agttgaaagg gggaaacgta gtcaccacca taaacaccac tgaaaactct tgatttggac    70920

catgaaggac ccagaggaag gccatgatgt atctgcttcc ctcaatcttt tgtttagctc    70980

tcaaaagcag aacctgtgtc ttagtcatct ttcctctcag tgtttagaac agtgaggcac    71040

attacattct caataaatat ttgtgcaatg aatgaatcaa gagtccattc tataaaggga    71100

attgtggcct caatgctttc taaaaataca aagaaaaatt ttttaaatac ttgagttttt    71160

attaatagtt ttatttgacc ctgggctggg ctgagctggg ctggacccaa tccccatccc    71220

agccacgtcg tggccctcag ttcagcttgg gcttggagca tatccccctc aggcaccccc    71280

aggctcatac gccgtagctt gtctgttttc caggtatagg tgggcagaag gacagggacc    71340

actggtgtca tctgtaagaa ggatatggct aggaaaaaca tcagagtggg caagactgat    71400

gatggagagg aacacctgtt ggtctggatt gagggactcc ctggaaggga cccctcttca    71460

cccatattcc aggaaagaat ttttttccaa gggcatgaca agtgggtttc ctagcagaat    71520

ggtttctctg cagcaggagc agaaattatc ccctttgccc actggccatc acccaccatc    71580

agtcacctct ccccacagga tgcattcgcc actgtccctg ctgcaaactg gataccacca    71640

agagtccatg ggatgtgggc tggcaggtgc gcaagacttg ctaccgtatc gtggagcaca    71700

gctggtttga gagcttcatc atcttcatga tcctgctcag cagtggatct ctggtaaggg    71760

gaggcatagt ccctgccccc aaatcctcca gataggaatc tcctacaatc caaaggccct    71820

ggagctgcat cagtgggttc tcctgactac tgagctgaaa gtccccaacc ttgtcactag    71880

aaggagagct gcagcccagg gcgagggccc ctcttagcag cagagcatgg gaggtgttca    71940

aggtgcccgt gccatggcct gccaaacctg gctgcaagca tttgagtgag tgagtgtatg    72000

cctcccacta tatagatggg gaaactgaca ctcaaaatgt ttaaaaggct tgtccaaggt    72060

cacccaactt gtcagtagca aaacccagct ttgcccttat ttaatcccga agcccctggc    72120

ttcccaccct ctgacctccc caacacacgg ccttctctga aggcctacaa tacaaaaagg    72180

actatctttc cttatcaaac cacttccaaa tgctactaat tactccttta aagctcacag    72240

aaaatcatta caatagcact tctcaaaatt taatctccca ggagcttgtt caaatgcaga    72300

ttctcattcc ataaatctgt ggcagggcct gagaatttgc atttctaaca agctcccagg    72360

tgatgcttgc actgccctca gtgacccaca ctttgaataa caaggcctta tgggaataga    72420

gattcagagt tgggagacat ctctaaggcc ctggctgaat actgggcttt gtagagcaaa    72480

gaaggaaggt tctctctgta ctgtggctta agctccttac acaatctcaa ctactccgcc    72540

aatagaccaa ggtagacata gacacaggaa ggaacttaac atcctcagtt gtttgcattt    72600

tctaaatgag gaagtcaaag cccaaaggca tgaggggctt caggtaatta gttgaagggc    72660

tgggaataga gagttcaggg tggcagctaa ttagttgaag ggctaggact acagtcccgc    72720

tcttccgatt cacggctgca gtgttttcac tcatcttgcg cctcatgtgt catttactct    72780

ctaaaaacaa cctactaaat atctaggcct ccatctaaat gccagattgt ccaggaaggg    72840

tgacaaaact gctcggtgca tggcctcagc tttagggagg agcacaggtg cgggacgagg    72900

caggatctga gaggtgggag gaaaactagg gtggcaatga cgcaaagcca agggagaaga    72960

gagtttcggg gcagggactg gtctgccatc ctgggtggag ggggaactgt gtgacagcgg    73020

ctgcaggtgc ccagtgccct ggcacagggc agtgattgtc cacacggacc tcagcacagt    73080

gtagaggcca aattgcaggg gcaagagagg gctgggcagt gctttctcca cacctatgct    73140

cttctccttc cagtcctgct ggattaaagt aataaccaca tgtgctgttg gccaggtgct    73200

ctcctcacta cgtcattggc ttgtgggcct tctctcctca ttttgcttct ctgctctccc    73260

ttgctccctc ccttctctct ctagccccct tctcttcaca ccccggtcca ccccccacat    73320

tcccaggagg aagctcagac ctgcagcact gcgccagccc agcccgcccc ctgcagctct    73380

cccttccctc ccatctcctt cccctgggac tgaacaggct ggcaccaaat ttagccttct    73440

ttaggctttc actttgagta ccttttaaaa ataacatgca ttttcatctg acaaagtaaa    73500

gtaccaaaaa aatacttgga aattatagaa aaaggtaaag aaaaaaaaat catccatttc    73560

cctatcactc aaagagaaac tcacttgaaa acatgctggt atacctcttt ctcatcttgc    73620

ttatgcataa aatatacaca tattacaaaa ataaaaccac atttatgcat tctataacct    73680

cagtacattt ttctcagtaa atagtctcat attatctcat ttaatggcta taacatattc    73740

ctttataatt tactcaacca atctctatgt ttacttctaa tacacattga atattccctg    73800

tgtgtactcc cttagagacg ttggataatc tcccatctta gtcctcgtcc tagacacaga    73860

atcggaagct gagaaaagat gtgggttcag ttgaaatccg gcttcagctg atcccatgga    73920

aagccctgaa gcacaaagga caccaaagag ctgtcccacc ttgaggcaaa gaagacagcc    73980

ttgtaaatcc ccctgtcact gtccctggct gagggctgcc ccagcgggga ggataagcat    74040

ttcccaaggt ggacacagtt tcctccagcc cagcgaagcc atcaggaagg gggtgtctgc    74100

atccatgaac tattagcagc cgacactccc agcagatgaa ggataggggc actggcccct    74160

taaagaggac ctgagtgggc accaacagcc tccagtgtcc ttaggattag tgcttgaagg    74220

aggaattgct aggttcctga aacctctgag tcacattgcc aatttggctt cacacaggac    74280

tggccaggtt ttcactcctg ccagtcactt gtaagagtgg ccgggcgcgg tggctcacgc    74340

ctgtaatccc agcactttgg gaggctgagg cgggcggatc atgaggtcag gagatcgaga    74400

ccatcccggc taaaacggtg aaaccccgtc tctactaaaa atacaaaaaa ttagccgggc    74460

gtagtggcgg gcgcctgtag tcccagctac ttgggaggct gaggcaggag aatggcgtga    74520

acctgggagg cagagcttgc agtgagccga gatcccgcta ctgcactcca gcctgggcga    74580

cagagcgaga ctccgtctca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    74640

aaagagtggc agccccccac agccacagca tcctagggtt tcccctattc ttttccatct    74700

ccaccagtct gataaaagaa aaacagcatc ttcttttaat ttgaatttcc ttgattacca    74760

gtgagataga acattctttt tcagaggtgt gttggcgatt cttactttca tttttgtaaa    74820

ctgcctgtga acatccgttg atgcttttat ttttaaacaa agtcactgtt agcatccctt    74880

tggttcactt ccaaaatcca atttgagaag gttttctttc tcccttgcat tcagcatccc    74940

tgcaagtatc agcagggctg tttgtcccca ttggccctga agaagtcatg ctttggatct    75000

cacagtacct cctccactat cccactttac ctccccacag caaacaaaat gctactggca    75060

agctgactac caaatcccct tccagggact gtggtcaggg ctggctgggt ccttccctat    75120

cagtctgggc cccagtgctg tgggtccagg cagcctgcca ttctgcatcc tttcttcctt    75180

ccaggccttt gaagactatt acctggacca gaagcccacg gtgaaagctt tgctggagta    75240

cactgacagg gtcttcacct ttatctttgt gttcgagatg ctgcttaagt gggtggccta    75300

tggcttcaaa aagtacttca ccaatgcctg gtgctggctg gacttcctca ttgtgaatgt    75360

gagtggctca gtgggaacac gtggggtttg gggtcctccc ctctgactcc tggctacagc    75420

tagggcaaag gaagctcaga gacctggccc tcaagggcta ctccaaagaa aagttttgag    75480

catttagtga ggagtctgag aatagccctg acacccatga gtggtaaagt ccaggcagta    75540

tgtgactgtg acacaatagt gactgttagg tgagttatta ggtctccatt cagaaagatc    75600

cctgcaatcc tctgcatttt tacatccaaa gtgagatgac acatgcagct ctcagaggtc    75660

ttatggccct gcatccatag atgggtcttc tggaccttgg ggagccatga actgtgagca    75720

cagagaatct tcccacctgc ggttctgtgg tcctcacacc tggctgcact tgagaatcac    75780

ctggggagct atgaaatatg cagtgaccga ccaccactac cccagagatt ctgatcttat    75840

tggtcttggg tggtgcccag gcacctgtat tttataaatg ctcccaggca tttccaaggt    75900

gcagccatgg cttagaacca ctgagcttat actgctgcct cctccccagt ggcattgaaa    75960

agaacagagg gcgcatttgg agaggtaatg agctggagtt catgtgttca cactcatggt    76020

aacctgtggc cagtaatccc tgcattagag aattgactgt gtgcttctca cacatcagac    76080

atgtgattcc tcagtcatct cttcctcatc ttaaccacca cattgcacta tcactgtcta    76140

ggccactacc ttctttgctt tgcagcatgg ttaactgagt tatctgttca ctgccgcata    76200

gctgagggtt tctgcaagca gggtgaggca tgtgctgtgt tggtctctgc ctgccccact    76260

caagcagctg ccagcagcaa ggtctgccca gcagaggtgt caggaaatgt gtctgtattt    76320

ggtgcttgcc tcctgaagct ggatgaggtt cagcacagaa cattctgtcc agcctcctgt    76380

gctggcaggt cctccatagc aggcctgtgc attcaattct cttcttccct gatgccaatg    76440

cactagcagc ttcaggccac tgtaccacaa ggattagctg tgaggcctga aatctgagtc    76500

atgggtgata attctgtgca tatgaaataa ttattcataa atgaaaggaa aattatttat    76560

tccggtgtcc cacccctttg ggggcacagt cactcctgct tatgttgatc tcaccagtct    76620

cagtcctaat caccttaaac ggtcatgcac tcatttcatc catcttccta ctgattcttc    76680

cttccaacca tccatccttc cttccataca tttcaccttt tgtatccaac cattcagtct    76740

tcctttttcc ttcctcccaa acatccatcc atctttattt cttccagctg tacatcttca    76800

tcagtcctcc ccttccatcc atccattccc attcttcttt ccctcttctc ttctgcccaa    76860

tcttttattc taaacttcct tccatctatt catcatcctt aacccttata tctttctatc    76920

ttttgattca ttcttctatc caactgtcca atcatctaac attctgttca ctcattcacg    76980

catcttccat ccaagcatgc ttctactcac tcatccttct atccactcat tcttctatct    77040

ttccattctt gtttcaacct atccatctat tcttcctttc ttccacttat ctgttcattc    77100

atccctttcc cttccattca tcatccattc atccatccta tcaaccttcc agtcattcac    77160

taatttattc cattcatcta ttctgtccag ctccccatct ttccattcat gcattagtca    77220

ttttacccag ccatccatcc ttctcttatc cacctatctc atctatccat tcactattcc    77280

ctgctttcat acttttcctt tcttgtttgt ttctcccatc cttccattca actatctatc    77340

ctatccatct ttttgtgtct gttatctttt aaaattttaa aaaatatatt ttattgtata    77400

tatttgtatt agtctatttt catgctgctg ataaagacat acctaagact gggcaattta    77460

taaaagaaag aggtttaatt ggacttacag cttcacatgg ctggggaagc cttacaatca    77520

tggcaaaagg aaaggaggtg cgagtcacgt cttatgtgga tggcagcagg caaagagaga    77580

ggttgggcag ggaaactccc ccttataata ccgtcacatc tcatgaaact tattcactat    77640

catgagaaca gcatgggaaa gacctgctcc catgattcac ttacctccca cagggtccct    77700

cccctcccac aacacatggg aattcaagat aagatttggg tggggacaca gccaaaccat    77760

atcaattttt aagggataca aaatgatgtt ataagatata tatatatata aatgattact    77820

atagtggaac atattaacat atccatcatc tcacatagtt acccatttct ccccctgtgg    77880

caagagcagc tataattact cagcgagcaa aaatactgaa aacaatatgc tattattaac    77940

tatagtattc atgttataca ttaaatctat cctatttatc attgtatcct ttaattcatc    78000

cctctatgca atcacccttc aacttttcat ccagctgtac ttctttcttt ctttccttct    78060

agccatccca atgatcctat ttttcttcca tttgctatac atctaactat tgaatacagg    78120

attgtcttat gaagtgcttt gtaagaaaca gaagcacaga ataaatactc actatctcca    78180

ggatcttaca ctttagtctt tcagcagaca agacacacat ggaaataaat gtattataag    78240

ggtgaatgtg ttgagcactg ctgggggcaa ttagtatctt ggagacacag agacatgagc    78300

cttcttccac tcttggggtg gggtggttga gaattcttcc tatgggaggt ggcattagat    78360

gtggggcata gaaatgagca ggaccaagga gctgcgagag gactggggaa ggcccgtctt    78420

agctaaaggc tgaccttgaa caaaggcaca gacacaagta tgctcaggga acaatttgat    78480

ttgggtagaa tgtgtgggtg aaatatgact ggaaaagtag gttgtgacca tatgacacag    78540

gctacagagt atggagttta tcctgagggt gataaagtac cagtgatgtt tgggagtaag    78600

agaaagacat gatcataatc agatttgcag tggagaatag atgcatggtg cagtactagg    78660

gcctggagac tacttgggag gctagtgggc tgagcagtgg gaatggaggt gggcttgggt    78720

ggacagactt tgctggagag gcacagcacc tgtctgcccc agctgcagat tatccatgtg    78780

aggcagactt cccagggggc tgagcaaaag actgaatagg gttcagcatg gaactggccc    78840

caaacctccc taccctcatg cacccaggca gctgggtctc acctgctgat gtctggagcc    78900

ttgcatgaat gaaggaagag ggtcccttcc attccggttc tttgtcctgg tgcaataagc    78960

cactcatcca aagaatggac attgcttggg gctctgccac tcaagtataa agcccttctt    79020

ttctgaagct cctgtgtgca tcccacctaa ctgccaggat aagctgagcc tgaattcagc    79080

ccaccatctg tggtgtggct aagatctcac aggacagggt catagcccgt atctatgaca    79140

tctccctggc accttcaaag ttcctagcag gggaactttt ttcatgtaag tttctgtcct    79200

ttgcagtctt tggaccacca cttaaagaaa actgacagac caaaaggggc tcacaagtca    79260

gtcattatat ctcagatatc tattgaagct agatctcatg gacccatacc agaaactttt    79320

tgaagaactg cagagctatc agaactttgg aattctctta gtctgacttt ttcattttac    79380

aaagggtgaa agtaccctgg actagccagg cactaaccca agctcacaaa aaatcagggt    79440

tcaaatggga attagacccc acccaaacca ctattctttc caccccactt ctctgagcaa    79500

atataattca gattactata ttcctcagaa tagactctca gcatagcccc taggagggaa    79560

catcatgtct ccaagtctct gaaaatcagt ttcaaggttg ttgaggcctg actgctgccc    79620

ctagaaggaa aaggaagagt tgatttaata cactggaagc ttggccacct acgtaccaga    79680

ggttggtgat gttagagact gagtttttct tgcccagatt gtttaagaga gtggtgaata    79740

aaatttttaa taaaagggaa gagacaaaac tctttctaga cctctcattg gagttccgaa    79800

taaggtggga gctaggatga tggcttagac gtgtaggaat gggaggctgg gcagggagtt    79860

cctgtctcct tccacgagga ctgcctttct ggaaacctag agtgatgttt ctgccctctc    79920

ctgcactcag atctcactga taagtctcac agcgaagatt ctggaatatt ctgaagtggc    79980

tcccatcaaa gcccttcgaa cccttcgcgc tctgcggcca ctgcgggctc tttctcgatt    80040

tgaaggcatg cgggtaagtc tgatctcaaa acttctctca tctggccagg cacggtggtt    80100

catgcctgta atcccagcac tttgggaggc tgaggcgggc ggatcacctg aggttaggag    80160

ttcaaaacca ccctggccaa catgccgaaa ccctgtctct gctaaaagta caaaaatcac    80220

taccaccacg aggtgtggtg gtagtgagcc gagattgtgc cattatactc cagcctgggt    80280

gacagagcga gactccgcct caaaaaacaa acaaaaaact tctctggtct gcaggttttg    80340

gtaacccttc cccctttatg ccctccatcc caccaaccct gagctccggg gccccacctc    80400

caaaggtagg ctctgagtct tcacttcctg ctctgacttt ggtggtgctg catgtcctaa    80460

ctctcttagt tctctttcaa gtctttttgt gggcccatct tcccttgtca cccataaata    80520

ttacagccac caggacccag acctcacccc ctttgctctt agtgaagtaa tcctgaatca    80580

tcgctccaca agcatctatt atctcaatca cccaactctg cctcttattg ccaacatctc    80640

cagaacatcc caagttctct gtctttccat gacaaatgag tctttcctct aatactccat    80700

gagtgacatc atcagctcat tacctcagct gccacccact ggaatgcttc ttctctccta    80760

cttaatgcaa tcatcaggtc ctgtaaattt ttcccttcca tccacccctt tccttatcca    80820

ccactgtcag cctccacctt gccctaactg cctccgtcag gacagaatgc tcacagccag    80880

agccttgtct tagagattgc tgattgacac ccacctcttc ctcataatta caaatggctc    80940

cccagcagaa agtaaggttt tgctttgctc cactatcatt ggctggaagt agtcatcata    81000

gcttcaaaaa caaaagtggg cttttgaaat taacttgtac ctttacaaac actaggaccc    81060

gaagattgaa atagtttgaa atttattcta ttttgtatct aatagattct catttgctta    81120

tttacaaata agctattttg tgaatatgga tttaggtttt cactggttct tgaccacggc    81180

atactttaaa ttgtatttaa attgtgtttg tgttttatgt atggtattta aggagaataa    81240

gtcaaggttc tagaagtctg tatgtgcaag tataatacac acactcacac ttctaaatga    81300

gtgcagtatg cttgtaaact catccatctt ctcactgcaa cccaccctga atgaggttaa    81360

gggaagaagg tctaaatcca tcttcagctg cccaatgtct ctcagtcttc tgagtctgaa    81420

ttattgcact aattaaccca cttctcttgc ttcttccaaa ggccactggc tcatgaagca    81480

gcctgaatga gtatagaaag agatagaatc cagcagaggg ggtggggcat tgggaggttc    81540

caggtctttc tctatctccc accaggtggt ggtggatgcc ctggtgggcg ccatcccatc    81600

catcatgaat gtcctcctcg tctgcctcat cttctggctc atcttcagca tcatgggtgt    81660

gaacctcttc gcagggaagt tttggaggtg catcaactat accgatggag agttttccct    81720

tgtacctttg tcgattgtga ataacaagtc tgactgcaag attcaaaact ccactggcag    81780

cttcttctgg gtcaatgtga aagtcaactt tgataatgtt gcaatgggtt accttgcact    81840

tctgcaggtg gtgagtcaac catgagatca accatatctc ttgctttggc cgctcaataa    81900

aatggagagt ctaggttccc agaagatgct atgtggggac tttgcaagga gtagcactca    81960

gtgtgaactg aggtcattct ctattcctac agactacacc atgaggctag agggccttcc    82020

tagtgaatat gatatcacag tggtgcaatt acacaagtgt gggctagtag aatagcataa    82080

agggatgggc ctgccatggg attatcaggt ggtgagttaa aacacagaac ctgtacaaaa    82140

tagacacggc atagccacat gttcagtctt caacttcaca tcatttccta aatggtaata    82200

aattatgtct cattaggtct attgtaatga tatataatgt tggtgataat gacagtcaaa    82260

cacattcatc ctgtctttct ttctttcatc atccagtcaa tcactcattt cttgccttca    82320

tctacctgtt cattcagtcc tctgttcatt caagtgttaa tacaattact tatacatttg    82380

tcatgcagtt actcttgagt gtctacattc caccattggt tcttgcattt attcaacaaa    82440

taatctctga gtagctctgg tatgccaggc atggtactac tcagccctgg gagatacagt    82500

cagaactggg cttggacact gatgctgtat gagaaacaga ctaataggtg aattaaaaca    82560

gctcattaag tgctgtaaca ggcctaggag tgtaagaact aagatgtctt gcatgctctg    82620

aacatgctgg aaggcacacc cagtttctag acctcaagaa tgctaaagct gaaggcagga    82680

acatggaggt cttctattct caacttctcc atctggaaga tataccattc ttacatcatg    82740

tgcataaggt gggaaagtgg ctgagaaaat ggcagccctg agaggggaaa ccttaggcaa    82800

gtgcacagag cagacttgta gcaattggca ctagaaccag acacctagac actcagtcct    82860

cagtccatac tacattctga aaggctctgt gtctttaatg ctactctatt cttaaacagc    82920

cacatgtggg attactttaa atcatcatat gagattagtc aagtaaccca agggaacttt    82980

tcctttcatt ctttctgcac aagccctttc caacacagga ctctctcctc tctcactggg    83040

ccaccatggc ttgggaaggg tccagtatag atggatgggc agacactgag tggcctctgc    83100

tccttgtctc caggcaacct ttaaaggctg gatggacatt atgtatgcag ctgttgattc    83160

ccgggaggtg agtctcagcc cactgtccct acagccttcc cctctgtgca ttctacccat    83220

atcagtctgc atttgaaatg aagtgacgat gaccctggta ctggaagagg cgatcaccca    83280

gcaacctcac actgtccctc cttgcagcag tgtccagctg gctctctgtt gagtgtttca    83340

gccaccgagg ctttccccct ttcatctaca ctccccaggc ttctcgaggt tttcctctgt    83400

tcactgttga ggaaagcatc agataacctc taagagacag ttcatgtgag ccactccctg    83460

gacaagggtg ggagcaaagc aagggtagta gctaaatcaa ggtgcatagg gaggaatgag    83520

gtagaatctc aggaactatc ataaaaccca ggatgggcca ggcgcagtgg ttcatgcctg    83580

taatcctagc actttgggag gccgaggtgg gcagattgcc tgagctcagg agaccagcct    83640

gggcaatacg gtgaaacccc atctctacta aaatatgaaa gaaattagca gggcatggcg    83700

gcttgtgcct gtagtcccag ctgctcggga gactgagaca ggagaatctc ttgaacccgg    83760

gaggcagaag ttgcagtgag ctgagattgc gtcactgcac tccagcttgg gcgagacagc    83820

gagactcaat ctcaaaaaaa aagaaaagaa aagaaaaagc caggctgggg agacactatt    83880

ggggaatgac cacttcctgc tgtggcaggc actgtcaatt ccctgccacc tcttccctta    83940

gcccacttct gatttcacct gcaggctgca cttctgattc tctgtataaa gactccaggg    84000

cttaggagct tgtgcagcaa cttctccccc aagtaccagg gatttaatgt ccctaggggc    84060

aacccttacc aataagtttt gggagtctga ggataaatac tccagtttcc ctgtcccttg    84120

gtgatataat cctgcatgtg ctctacacag ttactcagag gaccccagta ggattgcgct    84180

tcagttgccc acaatgatgc cctgcttaac aacatcctct tcacaggctc ttctcccatt    84240

cccgcttatt cttccccact ccctcattcc tgcttccttg gatcacctcc cagataaatc    84300

acctgcaccc aggtccatgt cttaggcttg gctttcagag tgaacctgaa ctaagacacc    84360

caccctcctt cccactctcc cttgtctggt cacaggtcaa catgcaaccc aagtgggagg    84420

acaacgtgta catgtatttg tactttgtca tcttcatcat ttttggaggc ttcttcacac    84480

tgaatctctt tgttggggtc ataattgaca acttcaatca acagaaaaaa aagataagtg    84540

gtgctcagga gtttctggtt tctgctgtag tggtaagcct tatatttcct gttccctgcc    84600

cagctctggc ctcctgacaa aagccaacac tactcacagc ccatcacttt aatatcagtg    84660

ctaacccttg ccctgtgatt gctgttgcag gaagagttgc atttctctct gtcagcaatg    84720

ccccactaac atcctcactc aggattcaca tctcaaaggg atcttggtct tcccaactgg    84780

aaccaggtgt gttagatgtg ttccaagtga gccctgggag aatacaagca gggaaagaaa    84840

gggatctaga acttgctgac ctgttggggg atatgatccc cacaaaggac tgagtcaggg    84900

cacctcagga aaggccatgg cccagcactg gcagaatccc aaccctcctt gggatgggga    84960

ggaaggcttg tgcctccaag ggtgccgact ctgattaata ggaatcgaat cccagataac    85020

ctctcatgtt tataagaaaa tgtcagggca ataaaggtat aaagtatttt cctattatcc    85080

tttcatttaa tgccttccat acccctgagg tagataggcg ctgttctaga tttgcgtaac    85140

tgagatcccg agagaaaagg ggctacatgg ataagtcaca gagtacatgc aaacctgggt    85200

ttgcattcct gactcaacta cttgtggatg gctcatgctg gcaatatttt aaacccctct    85260

gagtctcagt tttctcattc attcaatggg gctaataata cctactctct ggattgtggt    85320

gaggggtaaa caaaatcctg aacaaagatc actgagcata agacaacttt ggtggtgcag    85380

tttctggcac tgtaacagca gaggggagtg tgactggcag cgcctcaaga gcaccagatg    85440

ctgttgctat taacaattta aaatatatac ctactagggc aggcattcca cttacaggaa    85500

atccttgccc agggttctga gcataagaag aggacaggat aggtctggga caagacagtg    85560

ctatttagta ccctggggag gtttgagatt attgaagcaa tcatttctct cattttacag    85620

atgagaaaac tgaggtcaag aaacagatta cagagggaga tattaggtaa cggaaggaga    85680

tgagctagtg accaggctgg ggtcactgag aaactgcatc tactgaatcc ttggtcagag    85740

ttctcagcat gacctcacct ggagctcacc tacccactgc ccttgccctt tccttctctc    85800

cccccataaa gatggtcctc ccaggaagcc ctttgtgtcc acagatcttc tcagatctcc    85860

tttcaaattc cacagatctc agcccagttt cccagcattt gcagggacta acttacataa    85920

acatgttatt aaaataggtg gctttcaaat tatgtcagga agctaaaggt gagagtttga    85980

atgaagaaaa tccaaagggc ccctaaagaa aaactaatac ccaatcctaa gggaggaaaa    86040

catcttcgtt ggtgcagttt ctggcactgt aacagcagag ggcagtgtga ctggcagggc    86100

ctcaagagaa ccagaggtcc ctctgagacc aaggacccaa ggataaggca gtaattgtcc    86160

tcatctcctc ctctccagaa aagatttgag ggcttctgtc cctcccagag tctttgcttc    86220

aaggtcctca ggaaatctct tgccccctgg gagggactgt gactctagaa gcccaaagaa    86280

ttttactgga atgaacaggc tagatccaag gctcagattt gaaccaacat gtaccttctc    86340

cttgagtcct gtttaccaac cctccccacc ctttatccag catctctgga tccctggaga    86400

acagaaactg gctttgcttt agagacccag gcagggagtc agcaatggaa ctcagtccca    86460

ccgttccgac actggatgtg gcaagacact ccttgatgct gggcttggtt tgtctatctg    86520

cagaggaggg gagaaggttg atatgatcct ttctctcctg cctgttctga ttttggtatc    86580

cgtagggggt tcctcttgct ttagtaacag tgtggccctc tctgcactta gggggccagg    86640

acatcttcat gacagaggag cagaagaaat actacaatgc catgaagaag ttgggctcca    86700

agaagcccca gaagcccatc ccacggcccc tggtgagccc cagaggtttc ctctagcaca    86760

gcctgtctgt gaatccaaca tgacagtcta tgcctgtgtc aggcaggggc ctgagggagt    86820

gctgtttatg gaagagaaga tctgggttga cgttgggatg agggtgatga gggttcctag    86880

gcccaaggaa tgagaagttc aaaagaagca actctggtct tctggagtaa acataccttt    86940

tacagctatt tgaaatgaat ctgttggggg aagcactgag tttctccaac agttttagag    87000

ttcaagtaca ggattggagg caggttaagc taagtgacag taagggtagt tagaacccag    87060

ggattaaact tgtgtggtta tgtatcatgg tctaggtcgc agtagatctc cagtatcacc    87120

ctatattcta ccccacgcct acaggtatag agaggaaatg acaacaaccc aactcccctg    87180

tcaggatcca agatgcagtc atggtagtgg tcaagtggcc cagtaggaac caaaagttat    87240

cccactcgag tttaaagatt gggcaaaaat tagggccaga ctctagtttc actccttttt    87300

tcataaagat ctcaagagac atggctttgc gttcctccat taaatgtact acccatacca    87360

cacatgatat cacctaagtt cttctcagtc ttctgccaga agatagaaaa catcaagcct    87420

ctgagaggcc ctaagatagc acttttttgg gaatggatga acaggtttgg gggtgaagat    87480

gttgatgtgt cagaaattat tgttgatcgt cttcaaagaa tttctgagcc atccactcca    87540

gtgaatggaa ttggccctgt gtccttctac ataaactttc tgtggctaag atgcagcatt    87600

agtgaagaaa atcacaggta ttgctgatga cacaatttca ttagcccttc cccacacaag    87660

ggaaaagtcc aaaggacatt taacaaagga acaagccttt ccctaaatga attatggaga    87720

catgcattct gttagccaag ctattagatt tttttaaatc aaggtatagg atttgcataa    87780

tttacttcaa actttgtcag aacaaagtga aaaacattta caagagaaaa aagtgatgac    87840

ttttgacact gtattttgaa atagtggtca tgaatttatt actagtctag attctgataa    87900

gaagtattac aatggggagt ggggagtgat aggaggttca gacctctgta ggggcacagc    87960

tttcttccta aatcacccat acaatcaaga taactggatt tgagtgaacc tgagcaaaag    88020

tccttaggct cattgagtat ccctccatca acaagttcag tggagaggag caggctcaaa    88080

attaaaatta ggtgaaaggc tgagtcccaa ccacattcaa gtcatgggta atgagaggag    88140

gaccctaaga cttactgaga agcaagcagc tgagtccaca ctggccttta cttgtggctg    88200

gagtaagatt gaatccacat ttgagccaga tgccaaggag gtgtgtgcta gggacaaccc    88260

ttggcaaaaa catgaaagtt tttggcacct tcccccacat actactcaat ctctctttga    88320

catcccagct tcttccctgt catcacccaa ccccataggc tgccaaagaa agcttcctcc    88380

cctcaaggaa gacaacattc ttaggacaag ataaatcata tttcaaaaag ggaccctgga    88440

gagggcatct acctacaaag gcatgaccct aatgttgaaa ttccaggcag taaataggag    88500

tgggagacgg agttgatggt caggcaggaa gacctgcaac aaaatcacca tttctcctaa    88560

ttaagctgca actaagatcc tccgaggatg gcacaggggg agacctccac atgtggaggg    88620

gaagtgaaac ctcataacca attctgttcc tgagattctc catcctttga atggaagaag    88680

agtggattag taattcactc tcaacctttt gctagcctta gtggaggaac gtggctctcc    88740

ccttaatatt ctggcccaag caaggtaaac actctttcct ttgttcccta atttcgcata    88800

gctgaggcaa ggctagaaca tttaaacaaa actttgaagt ggcagggatg ccaacagaga    88860

aatcagcaca aagcagagtc caagcagcac ctgcagatgg ctgcactcca ggacccatag    88920

gtcttggacc atcctagctc ctgaccagca tccaaatggc aggcaacatc tttgacaccc    88980

acatgcccag tggcacaagc cggatcatct tccctcttca aagtctagaa ccaagaaaga    89040

aatccaaggc aaaaggaaat tcccactccc aactaagacc cttcttccca ggcccagctt    89100

gcttttggcc agattattgg ccctggaatg tccaccttct ccccttagga gccccaaagg    89160

tcaagctggt cataccagca aagcactgac acaggatttc tgccccatca gtgcatgggt    89220

gccatttcat gacagagctt acctgggacc acataggagc ctcacacacc tcctctcacc    89280

tctgatgatg ctcaggctct aaatcttgtt tcttccatag gaaaagttaa ggattccaca    89340

agactgggaa attttattct ttaacattcc ctgctacaga aatcaataaa agcagctctc    89400

acatactcca ctttatagaa atataatagg ctctagagaa tatcacataa tcaatcaccc    89460

acttcatcgt ctctgagagc accaagggtt gcaaaggtat gatccctgac cgtgggctaa    89520

tccaagagca gctagcaagc tactccattc cctaaagtca gaatatccag ggcaaacttc    89580

acacccagcc acttaacgat gccgttgcct gctctgttta attagaagtc atgtgaccat    89640

gaatgggcct gtattttttc accattttca gtgatgaaat ggaagggatt agtggctcag    89700

caatccccct cctgccccag gaaagatgtg agccagcagt tctgccatga gcaaaggcca    89760

ctttggtctg attctttgct ctaacccaac aggatagcaa cccatcccca ccatgaagca    89820

gaaggcaagg atcagcctca tcacagcact tccccctctg cttgctgtgc agctcccgtg    89880

ggctccctgg aagggatcag acaggttctt ctcttcctcc ctcatagcca ctcatgcaga    89940

ggcttgcaca tcccatacat tcagtatgta cccttggtac agaattgaat ttagtcaaat    90000

aaagggtgac tttaaatttt catttgagct atggttaact cagagctgcc cattctgtct    90060

tccattcatt tacaaatttg cagagcatct gttgcagcca ggcactatgc agacaccagg    90120

gttagagcag tgagcaagac agacaaagtt cctactctta cagtttacag tccagtgaca    90180

gaggcaaaca gttggccaaa agttgcacat atatgttaat tcctggctgg ataaattgtc    90240

aagggagaaa aaatggggtg aagagcaaag gatgctcaag actgagcctc gaagaactct    90300

gatgtctaaa agttgggtaa aggagactat aaaagagcat cacaaatggc aagaaaagaa    90360

gcagaaatgt aaggcatggt ggagaccaag aaagcaacat ttcaaggtag aagggtacta    90420

ggcaatatca gacaagcgtc cttggatcta atattatggg aagtcattca tgatcttagt    90480

gagaacaatc tctgtcagga tagaggcaaa agctctgttg atgtgggctg aggagtgaat    90540

gagggacact gattgtacac aactctttca agaaattttg ctttgaaggt gggaagagat    90600

ctaagatggt agctggaggg agatgtaagt ttctgaaata ttctgcttta agttaggaga    90660

aactaggtca ttagagattt gtgcaataaa ccaagagaca aagagtaatg cacatggaca    90720

ttaatgttgc ctaggataat agccaagagt gggcaaatat ggccaagagc ctcacccatc    90780

attactgagg cagagggacc aagagtttgg caagcggcag taatgaagaa gtgacaaaac    90840

taggtggcaa agcttcaaag caagaagggg ttttacaaga cacaggaaga gcagtggtgt    90900

ggaagggtca gtggtgaaca aggagaacgc caggcctaac ccctgaggta catggggtag    90960

gggagaatgg cagcctttga atagggggag atatgtgcag atcaaggcag gtgagctcca    91020

tagaggtcag gagaagtttt gggagaaggt caaagcgtgg ggaatggggt tgggatcaag    91080

gactcacaga gcagtaagat gttcacagca ctaaaagaag agaagatcac agtaggagct    91140

ttttaaagac accataaaaa taaccagata taaatgatct cttggttatc caggccactc    91200

tgcctccttc caagatgcaa acaaccaaga cttgacccta cgccctatac ctgcatttgc    91260

ttaggcattt gcacagcacc aggaacagag ggaacatttc caagaataag tttccccttt    91320

gcacttgact ttactctcag caaagtagct caaattaata tttcaagcag ctcttgaact    91380

cttgcaatgt gcagggcact gcagggaaac aaagttaagg aaggtatagc ccttgtcctc    91440

aaacagctca ttgtctagta gagaagacgc atatacaaaa tgctagaact cgaggctgac    91500

tgaaaagtgg gatccccaaa gggacagggt agtgtgttgt cacgtgacta agggacactc    91560

catgcagtaa gtggagctta aaagagatgg attactcaag actgttggaa tttagacagc    91620

caagagagga gataggaggg cattgtgaat agaggcaagg gcacagacca ggacaaaaga    91680

agggcctggt ggcatcaaag ggccaggaga ggtattaagg acttgaactg gggcaatgag    91740

gtagagtcaa ctaaaagtga aattttggaa gaggtaagga tagtatttcg cttctgttaa    91800

gatgtggagt gtgatggaga caaaactcat ctacagataa cacagatgcc tggtttgtgc    91860

tggcccaaag gccctgatgc cactatctct tgttttctca gaacaagttc cagggttttg    91920

tctttgacat cgtgaccaga caagcttttg acatcaccat catggtcctc atctgcctca    91980

acatgatcac catgatggtg gagactgatg accaaagtga agaaaagacg aaaattctgg    92040

gcaaaatcaa ccagttcttt gtggccgtct tcacaggcga atgtgtcatg aagatgttcg    92100

ctttgaggca gtactacttc acaaatggct ggaatgtgtt tgacttcatt gtggtggttc    92160

tctccattgc gagtaagtgg gcagccacgt ggtggggaag ccccacctct gtttgggggt    92220

ctttgggatg ctcttctaaa accaaggaaa taaccaacca actttttgaa atacgtgttt    92280

atgttagaag aaccctgtat ttgcagcttt ccaagagtag caagttttaa atgccttggg    92340

ctgctctctc agtgaaatga agaggttctc ttggccttct ccatgctcac acgaagtgtt    92400

ttcaggcacc tactgtgtgc acagcccatg gctagaacct caggggctga cagggaataa    92460

tcactcctcc tgagaacctc agaccgtaag atgatggagt ctccagcaga ccttactttt    92520

atggtcttga aagcaggggg caggtggtgt aatgtgagat gagtcttaaa atctgttctg    92580

gaaaaggaga tggattgcca tcaaagtgag gaaagactgg gaggagattg ttcaaaggag    92640

attctcaagt ctagggtctg gaattaaatc tctacacaac tgttctatta gggaacatga    92700

gtgatagaaa agtcaagata tcaatgccaa gaaattaata ctgttaaggc ccagtctggg    92760

tgttgttgaa tgacaggccc agtattttgg gtccagtggt gttcagagaa aattactaga    92820

gttagaggct aacatgggga aatggagctg ccttgactga atacttccta agttctgagc    92880

actgagctgg gctccatgaa tgttcacagc agccctgtca agcaggtgtt attatcctta    92940

ttttatacat ttaaaattga gactcagaga tcaagaatat tatgcagggt cacagagttt    93000

ccaagggttg aagctgagtt tagaacaggc tccaatcttc taatgaactt gctgcctgtc    93060

accaacagcc aagagactgt ccctgggctt atgggttagc tgaagtttga ccctataaag    93120

gccaaatcat gctcaccagc ttcacctggc attataaatg tatcttgatt ggttatatcc    93180

tgacctgctt acttttcatg tcggggtgta gctgtagatt taatttgcca ctgatttagt    93240

aacaagagct gagagtatct aaatacaact taacagcatt tcatcaacct ccccaccttg    93300

gtgctgaaac acagccttgg gttgcgtgta tttccgggga tttcagtttg tttttgttct    93360

tgttttattt tgatattgct gctctgtttt ttaacacttt attgaggtat gatccacatg    93420

taaaaagcta tacatgttta atgtacacaa ctttatgagt ttggagataa gtatacaccc    93480

atgaaaccat caccaccatc aatgccagaa acatgtccat aacctccaaa tatttcctcc    93540

tgcctattta tttatttatt gggtgctagg aacacttaag atttattctc ttggcaaatt    93600

tttaggtaga caacacggta ttgctaacta tagggactat gctataagta gagctctagg    93660

atttattcat gtcacataac tggaagtttg tacactttga caagtacctc cccaatttcc    93720

cctcctccca gctcctggaa accaccattc tattctctgc tcccatgagt ttgactattt    93780

tagattcctt atataaatgc aatcatgtcg tttttgtcct tctgtgtctg gcttatctca    93840

cttagcataa taggagtttt tgttggttgg ttggttagtt gttttcattt ttgttttgtt    93900

ttgtttgtct tccaaaatga aagattccaa aggctatttt gattttatat taaagaaggg    93960

agcttgtttg tgtatcagta atatagaaat aaaacatagc caagtactta gttctatgat    94020

ggggatatct taactaccag ttcctgtggc ttacagggta gcaccatccg ctggggcagg    94080

aatcccttat agagctggaa aataagcaga aaaaacccac atatcaatct ttctaccctc    94140

tctccttacc tccctttctt ctttcccacc aacaagaggt gattgagtat ctaattgtta    94200

caagtacgag gaaccattct cccttaaaat aagatcctgg agcaaattaa aatgtgctgt    94260

agaccagttg tctggcagaa aattttacca gagtatgtag acaaataatg taccctacac    94320

gatgggaaca tgtcctagtt aaactggaaa ttcacagaag gtcttccaca aagattttat    94380

aatccaaaat tataattatt tcccaagtcc ccttctactt tcttcctctt tccaacacaa    94440

tattgtgacc catgtgcata acaacaaaga gcaagtaggg gagagggccc agggaacctg    94500

gcaaggagcg agagcttgct gctacatccc tcaccatttt tcctgtgaga tgttgaaccc    94560

tctcttacct aaaggccttg cctcatcttt ggtggaggcc tttggtacaa ataaggctcc    94620

ccaggtcccc aagaccaaaa atcaaacatc ttcaagttag acatcatata gagggacata    94680

tacattcttt atatttccaa ctttgttcat agttggagtt gggggcagta actgactccc    94740

ccaaaaaaac ctatctccag gccctaacat aaagttcaaa aacagctgga accgaaaaaa    94800

aaaaaaaaaa aacaaattaa ggcattgtgc agacagctgg tcattcaaat cccttatgct    94860

ttagctgtca gccagttgcc cgaatcctca ggcccccttg taattaacac caggctccgt    94920

acaattagcc acaggaccgg gtgccagaaa cagagtcaat cttcacagta ggaggtaggg    94980

agaggaatca taaggggtcc tggccttcac agagcacagg accagggtgg aggaaagggc    95040

atgacccaaa ggctgcagta tcagggagga gcagggtctg tgtcatagga aaaaacaggc    95100

caaagactgt gagcctgtgg aataaactgc agtcacttcc agctgaactt ggctgcagaa    95160

gataagtttt tgactgtgga ggttgaccaa gaggatattc taggcggagg caaagataac    95220

atggtaggaa gggtaagacg gaggaggaag agaggactta tgcaatgggc atttactgag    95280

cccctacttt gtgctaccta ccatgccagg ctctgagggc ccagagtcct caaatgtgga    95340

tgcccaagtg gcagtctata ccaagcaaag cagagtgtca tcacagccaa ctttgtcacg    95400

tctcatggct ggagatacta attagataat ttcttccttc ttttaaaggc ctgatttttt    95460

ctgcaattct taagtcactt caaagttact tctccccaac gctcttcaga gtcatccgcc    95520

tggcccgaat tggccgcatc ctcagactga tccgagcggc caaggggatc cgcacactgc    95580

tctttgccct catgatgtcc ctgcctgccc tcttcaacat cgggctgttg ctattccttg    95640

tcatgttcat ctactctatc ttcggtatgt ccagctttcc ccatgtgagg tgggaggctg    95700

gcatcgacga catgttcaac ttccagacct tcgccaacag catgctgtgc ctcttccaga    95760

ttaccacgtc ggccggctgg gatggcctcc tcagccccat cctcaacaca gggcccccct    95820

actgtgaccc caatctgccc aacagcaatg gcaccagagg ggactgtggg agcccagccg    95880

taggcatcat cttcttcacc acctacatca tcatctcctt cctcatcatg gtcaacatgt    95940

acattgcagt gattctggag aacttcaatg tggccacgga ggagagcact gagcccctga    96000

gtgaggacga ctttgacatg ttctatgaga cctgggagaa gtttgaccca gaggccactc    96060

agtttattac cttttctgct ctctcggact ttgcagacac tctctctggt cccctgagaa    96120

tcccaaaacc caatcgaaat atactgatcc agatggacct gcctttggtc cctggagata    96180

agatccactg cttggacatc ctttttgctt tcaccaagaa tgtcctagga gaatccgggg    96240

agttggattc tctgaaggca aatatggagg agaagtttat ggcaactaat ctttcaaaat    96300

catcctatga accaatagca accactctcc gatggaagca agaagacatt tcagccactg    96360

tcattcaaaa ggcctatcgg agctatgtgc tgcaccgctc catggcactc tctaacaccc    96420

catgtgtgcc cagagctgag gaggaggctg catcactccc agatgaaggt tttgttgcat    96480

tcacagcaaa tgaaaattgt gtactcccag acaaatctga aactgcttct gccacatcat    96540

tcccaccgtc ctatgagagt gtcactagag gccttagtga tagagtcaac atgaggacat    96600

ctagctcaat acaaaatgaa gatgaagcca ccagtatgga gctgattgcc cctgggccct    96660

agtgagaaca ctccagcctg gatatgttca gttatgatgc gtccttctgc tctgtgttaa    96720

ctctttccca ttgcagatca cacccagcta cagcctcacc aatgcatgcc actggtcaca    96780

atgtcagaac tgggcaggga atgcaactgg taaccacctt tgaaaaaacc atcatacaca    96840

aataggagtc agaagctaag agcacttcca ctgtgatttc ccttctgaat ttcaatatca    96900

gatcatgggt tctcttactc tccagaaaat atcccttgtc cttttatttt tgttgtaatc    96960

agattatatt tactgagaca aacttctcag gaccagaact tccaaagata tagaacaaga    97020

acattactga aggtccaagg tagtcctctg tggagcacca tacagagatt ggcaatatta    97080

tttaggattt tgcatgactg catgtgagag ctgtcggaca actgctctga cccagggtaa    97140

cacctgtggc ctatgtcatg aaaagccttt gagatatcca ttaaaattaa tatttttaaa    97200

tgtatgtcc                                                            97209


<210> 5304
<211> 107209
<212> DNA
<213> Homo sapiens

<400> 5304
aggagtttga gaccagcctg gggaacatgg aaaaacccca tcaaaaatat gaagattagc       60

caggcgtggt ggcacatacc tgtagttcca ctacttggga ggctgaggtg ggaggatcac      120

ttgaacatgg gaggtcaagg ctgcaatgag ctgtgattgt gccactgcac tccagcctgg      180

acaacagagt gagaacttgt ctcaaaaaaa aaaaaaaaaa aaaaggaggc aaggggaacc      240

aaatatcgct gttggttcat cttgggaggg ctgaatgccc accgaataga aaggcttgct      300

tagcaggaac agctattaaa cttaagggaa tatacctgca aaaactcatg cagactgttt      360

gaaagccagg gccgagcttg gagctaaact agaatagata tttcttggat tgtctcctcc      420

tcagccatta atccaagaag tgagtatcag gcccagacta atcctataac acatacattt      480

gatatggcta cctcacaaag gatgtgcttt ccccactaca ttcaactaga ctctaaaata      540

gggattccca attaaggttg caaggactat agccgtcact atctgcacct tgctcatttc      600

ccagggatct agaccagagg tcaccagcag acacttccta catgtgactt cctgcctctg      660

tctgcccagg gctttctctg gccactgaag taagttctgt agagttaaaa tcccaggaca      720

accgtcaacc aataagggac aggactggta gataaaaccc tagtatcctt acccctcagt      780

gaaacaattc tgagcccagt ttgcccataa gagtaaatgg ctcataaaaa tactgctttc      840

ttcttcttat gttacttttc ctctcttcta tgacattcct agaaatagct ctcagataaa      900

ctacttgcac cccaatagtt ttctcagaat gtcatgtaaa gacactgggt aatagatggg      960

aatatagaga accacttcaa tcaagggatc ccaagtccag agctatcact tctgatggga     1020

aagtcttaaa agaaggactg gtccctcata cctacatcac atcactacaa attcccaccc     1080

caatgttgaa aacaattttg tccttagctg gagggattta tggtagccca gaataattat     1140

ggtcatttgg catgaagtca gtctcatagc tgagtctgct ttgacctcaa gctccagctc     1200

caggacctgg aattctggct tagtcctgtt ctcaatcctc aacattgcat tccagtgtca     1260

ctgagagaat tcttgcattg ttactaaaca actgagtcct gggattcaaa tttggttcca     1320

aactataagt atctcttctc ccctagacaa ggaagagaaa gttaacttaa tctttgtttc     1380

tcagaaggga agaattaaag acactgaagt caacagtgtt tgaatggtca ttgcataaat     1440

acaccatgtt aatcagaatt tgggcacaca acacatagaa cttctaagtt agaagaaaat     1500

agaagacaga tgttcaatta tgtaatgtag gttgactttg aaaagttccg taagaaacag     1560

atcaactaca aataggcagg aggagaggaa gagggtgagg gaaagctctc agaagaaagt     1620

aatggaggac attaaggaag aggaatggtg tcagagcagt gagtgctcct cccaggactt     1680

caatgcatgg aaggactggt gacaaccagc agagcctcct acatatgggt attgggtacc     1740

agagctgcct ctagggctgg tgacaataag cagtgtctat atcacagagg tattggattc     1800

aagaaatacc tctaggtatg gtgggagcaa gcaggatctc catcataggg gtatttgatt     1860

taagcactgc ctctgccacc atctgcttga ctttggggtg tgtgagcttt aaaatgtcaa     1920

tagactcaat aatctctttg gttccttata ttcctattat tggatctgtg atttttgctg     1980

catttttctg aacaaaatgt tctttagttt ttcagctatt aagtttcgcc attatctcta     2040

ttcatgcaac aactatctat tctgtatcta gttagttcca ggcactgtac taggttctgg     2100

aaaatcaatg ctgaacaaaa tagatgtgag tccagctctc actgagctta caatttggta     2160

gaaacaatag aaaggcaaac agaaattaca aatcagatgt ttatagagaa agtgcagaga     2220

gttatgggaa catgaaacag gaatcctaac atagacttca tataggtcag aaatggaaga     2280

aattgtctca aagccaagag tacaagaata agagaggatt agccagacaa aataaagtgg     2340

aaagataatt ttaggcaaag gaaggggaat atggaaaagc cttaacataa aaaagaatgg     2400

gtcaaattca aggataaact tataaaagta gtgtggctgg ggactaccat gctggagagg     2460

tcagcgcaca gtttgggtta tcttgagtgc tatggagagc tttagaatga ttttaaataa     2520

agatatcaca taaccagatt ttcattttag aaatatcatt tggccactgt tggagaatag     2580

gttagaaagg actaaagggg aatcaaaatg acacatacga ggccagtgag atgacagtga     2640

ttggaccagc agtatgatgg agaggttaga gagatatgaa gagaagatat taaggaggca     2700

gaagcaacag cactagatgt ttgattgtat gtggaatgaa atagaaagag cataattatg     2760

gtacccaggt tgtggacaga cacagaaaca ggctatttgg ggctaatggc agtaaaaaga     2820

catagaagag aggcaggtat tagaaagaag tgaggagata attatgagtt tagtttgggg     2880

catgctgagc ttgaggtgct catgagacac tgaagtggag agatcaaatg aagatctgag     2940

ccccatggac ttctgagagc tacagataaa gactcagtca tctgcatata aatgagaagt     3000

gaagatatgg gaatgatgag atgtttccaa gagattgtgg caaacatacc tgagtttaag     3060

taccgttctg ccactcatta gtaatgtgat cttggaaatt ttaactttgc tgctctggta     3120

tcttatttat atattagaga taatacttca caggtacagt gatagttaat gtaataatgc     3180

atgaaaattg cttaatccag agtctgaaat acagtggaat ctcagtaaat gctagcgctg     3240

ttgaagttgt tactattgtt attattctga aaacaaaaga tagagtgcca ttattcacaa     3300

tcatgtatgg gaaaagctga gaaaggagag actgagaagg agaagagaga aagttaggaa     3360

aaccaagaga gtgtcatggt agccaaaata tacagtattt taaggaggaa attgtcaaaa     3420

cagccaatag gaccatcaag ataagaactg agatgggcct ggacaatata gtggtacact     3480

gcctacaaaa aaattttttc aaaactagcc gagtgtggtg acatgtgcct atagcccagc     3540

tattcgggag gctgaggtgg gagaattgct tgagcccagg agacagaggt tgcagtgagc     3600

agagattgca ccactgcact ctagtccggg tgacagtgat accctgtctc aaaaaaaaaa     3660

aaagaaaaag aaaaagaaaa aaacaaaaaa gacaagaact gagaagggcc ccctgacttt     3720

agccacaagg caatctcttg tatccctgca aggaagcatt ttagtgagat aggagggcaa     3780

aatccaagct tcaaagactg aaaagtgact ggaaacagtg agtagaagta agtcctttat     3840

taaaagccaa tagagaacag gagagaggag ggaagacctg gatgggctct gcatcaaggg     3900

aaagttttta aagttggagg aaagttaagc atctttaaat gctgatagga aagagctggc     3960

agacaaggag agagaaaaaa atgaggtaga tatgagataa gatcctaagc agagggaaag     4020

gaatggtcct tagaatgtag gaagatacct ctcatgttgt aagagaaggg aaggaggaaa     4080

gaaggctgca gacacaggtg agttggaggt ttgatggtat gaagttggca gagttctgtt     4140

tttctccatg aactaggaaa tatggtcatt ggcttactgc aagggaagac agggaatagt     4200

gagaaaagag tgtatttgaa acctcagact agaagaaact gctgactagg gataccatat     4260

gattcccagg caatactgag gttccccata acccctcagc agttcagggg aactgttcta     4320

gattgactta gccttgggat ttaggataag ggtgagggag tggcaaaatt gtggaccaca     4380

ggtctaatct ggttatgggg aaaagtgttc agccacagac tgaacctgga ggtcccagag     4440

aaattggagg tcccaatgaa attctccaat aatctggagt tctccagtaa cttggaggtc     4500

caaatgaaat tcaaacaggt ggagaaatgt tgacaatgtc aataaataaa agattgtgat     4560

aagaaagtag catgagactt aagataaagt agactataaa ccaaagtctt tgatgaatat     4620

gggagagtgc ctggaactca gtggtcctgg aaatgaggag agagggcagc atggctaaat     4680

ctggtggtgg tggtaggatg gtacaaagtg gtgaagaagc aatgacatag aagcacatgg     4740

ggagcaaaga cataaccctg aggcacctgg aggagggttg aataaacagc ctcccctgaa     4800

tgccttgcag gggaatgggt tcctgggagg agccaagtgt gagttcaggg aggggccaga     4860

tatgagggtg ggagaagggc tgttctgaca atcaagatgg gacagatgag agggacaggg     4920

ccagtgggca agctgtcacc tctctgtggt tatgtccact cttataagag tataaatact     4980

tcctgaagaa gaatgagaag atggaattcc ccattggatc cctcgaaact aacaacttcc     5040

gtcgctttac tccggagtca ctggtggaga tagagaagca aattgctgcc aagcagggaa     5100

caaagaaagc cagagagaag catagggagc agaaggacca agaagagaag cctcggcccc     5160

agctggactt gaaagcctgc aaccagctgc ccaagttcta tggtgagctc ccagcagaac     5220

tgatcgggga gcccctggag gatctagatc cgttctacag cacacaccgg gtaagagcta     5280

ctagtaggaa tgtctgctct cagctcttgg agaggaagtc tcggtcccac ccagcccaga     5340

aagtcctcct tggccctggg tgatgtggca gtctgctaaa gattccgtta acaaccaaaa     5400

aaaatatata tatatatctc taacttattt gatgatctct ttgaattttt atgacattta     5460

tgatagaaac taactaaacc cacatcttca aaagcagata actgctgcag agctttcagg     5520

gaaagttggc tgttcccttg gatgacctct ggcctggggc ctccagagga gttgggtctc     5580

tttgcaggtg gagagcagac atcttgaggt tgggggagga gcatggcggt gaggacagaa     5640

agcaggatga atttaagcca gtggtcctca actatgatct tggaacccct ggtgtcccca     5700

aaactgtttt agtgggttta taaaatgaaa actattgtat aacaatactt ggatgtaatt     5760

tgtctttttc acacactttc tcttatgatc atacattggt gaatatagag gctattgatg     5820

ggggatgatg tcatcactct aaaagctact ggaatgtgtg cctgtatatt cccgtgtttt     5880

aaaatttcct gagttttgaa tttctaatat gagatatata tacacacaca tatgatgtat     5940

atatgtgtgt atacatctat acactatata tatacataca actatgtata tacatacaac     6000

tagaccatgt agctagttat gtatatatag gtatataagc atatatacat atatattaat     6060

ttctaatatg atatacatat atctggcata aacaaaaagg tatcaacata aacaaaagtt     6120

atttggggtc ctcaataagg tttgagagta ataatccctg aaatcaaaaa gtttgagaat     6180

cagtagttta aacaagagct tcttcatgac aattatctca cctgtgttgt atttttgatg     6240

ttctacgagc caaaaaatgg tgaatgcatg tttgggagtt aggaggacag gaatcagcca     6300

tctcaaatat ggctagcaga gtaaataaaa aggcactgaa tatctttctt cctcctctcc     6360

catgccaaga gttcatatcc tcctaaatcc tcagagggag aaaccaggag aggatttaag     6420

agacagagat gtagaaggtg gagacagaag aaacattaca aaacaaggat ggttctcttg     6480

tcagaagaga aattaaatgc aaccataact tcaccatcct gttgccagag tcctcccctg     6540

ggcataacac ctcttaccag cctgaggatt ggctgtctgt ccattaaagt accctcagtg     6600

ggctcatctt ggtgcactgt cagtcccaga gatgaggatc ttgctgagag ggtgaggata     6660

tggcttttag tccttgatcc tctctgcctc tctgtacctg catttgactc tcattgacct     6720

gtagttccca gagcccttct tgctcataag cctgagataa tgcctctcat gtttaaaaac     6780

atggttgtat aaggaatctt gtttctcatt ggaggtccac tttctgtttt gttttgtttc     6840

agacatttat ggtgctgaac aaagggagga ccatttcccg gtttagtgcc actcgggccc     6900

tgtggctatt cagtcctttc aacctgatca gaagaacggc catcaaagtg tctgtccact     6960

catatccttt gcacgattgc ctcttccacg tgttacaatt agaccttgcc tactgtgtcc     7020

agtaccttct ttagaggtta gcaacagagc ccttatccaa ttgaatccca aaagtacaat     7080

gaggtcatta gattgaaaaa atggcttggg cctttaatgt gtcccacacc ccaaagcagt     7140

cccaagacac agaagaagtg tttatgcaac acacaggtgg tttggattca cctcagacta     7200

atctagacac acctgtggat gcacaacttg aaaaacatcc tctttatgag gggaggtttg     7260

ctgatgcccc cagacacatt ctcaccacgg tgtgtggtcc gctttcccca caacacaaca     7320

ggcagtaaga gggcccaagc cttctttggg cagatgagat aggcatgagt tgttgctctg     7380

tgccatagcc atgctgagaa gtggctgctt actgggcaaa agagcagcac ctcccagagg     7440

gcaaggaaaa cagaccatga tgggaagagc acacatagtc tcaatgggac ctcattggtc     7500

atggggcact gttaacatca caaattactc aaaaactact agcaggttta aaatgtcaat     7560

aatctgatgt tcatgccata caagactgta atgattagag acacattggt caaatgtcta     7620

ctatatgaat tgttttaggt aatgtcagaa gctgctttca ggggattttg caaggcaagc     7680

caaactagta gaaaaaagat actttggttt ggtttcctaa gatcttcctg ggtgatccta     7740

atggaaagat cctaatgacc taagatcctt ggtcatcgga aggattggaa gttctttatg     7800

acaaatttag ccctggcttg caggaggttg atgtacaaga atacacctgc ctcagttgcc     7860

tgacaaatgg taaccagcct tttcttagaa ggcttcagta aaaaagagtt ctaccctgct     7920

ccctaactct gaggcagatt gttggatttc tggacagttg tcattgagct ggtaaccttg     7980

gcacagtcat ctatctgcac actcaacatg aagctgcaca gcttgatgaa gttgcattac     8040

gttttctctt tttacatttt tttctttctg gctggccagc aagaattacg ttttctgagc     8100

tgaatcttga attttcagat tctacagaag gatatttaat gacaatacag tctctcactt     8160

gctaaatact tcctaagtgt caataccatc atcagttcaa aagcctctga agtagagatt     8220

accatcccca ttttacagat aatgaaactg acacacagag gcattaagta aattatccaa     8280

gaccatgtag ctagttaaga agtccagcct gcatcctgcg tagagcagta tctacagtga     8340

ggaagtaggg tggaaagtaa tcagggtaat tattctctca atgtgtcgtc tctgcttggg     8400

tagttgttgc tttttcaaaa tatatacaat tacatggaaa ttacaaataa agagaaatca     8460

caaacataca aactcctctt tatggattct ggttgaatta catctggata agtaagaaac     8520

agctaattag aaataaaatc ccctaaaaag aaccaagtga ccagtgaata ttctcttcat     8580

cttgagattt gatgagtaaa taattgcttg gtagagtcac agctggacag aaaagctgtt     8640

gagggggtct cttcctcaca aaagtctgca tttaaatctc ataaatttgg taactccagc     8700

cccaaaagat actagaattc tcagggccct attattaata tttcaccaaa aatataattc     8760

taatcacatt tgctatgaat gttttcataa ctaatattat acataagata tattactttt     8820

aaatatttgt agaattggag acacgatttt agtttaatcc ttggattaac atttcccccc     8880

atgtgagcat atttcttaat ttaattgtaa gtcagcagga aaatgtggtt taattaatag     8940

aattttcctt ttcataatag atgtgttcct aagtaactgt aaaactagac acatcaaggc     9000

atttacagaa aactaaaata catttaaata cttctgctca aattgaaaaa tgagtgttgt     9060

actctctctg taggtcaagt ttatcttcaa gttttatttt tccttaggaa gcactgttgg     9120

gagcccagct attcctaaga aaaatgtcca agtgggaaca atttaccttt agattctccc     9180

caccaacatt tcttcccttc tattttcccc ttccacccac cttcctttca atgtctccct     9240

ccccttttga taatcccttt gcccatagtc tgctgtcaat attctccact ctagctattc     9300

agagttctcc actccagcct aatcctactt ggggttttct tcctgagcca gtatttcatt     9360

tccctgtgcc tgcctccacc gttcctaccc agaagaccat ttcctcggtg gaactgatct     9420

caactaagtt acccaaacaa tctgatgaaa ctaattccca tgaaagtttg tacctcttca     9480

cttatctcca agtttctaac ttttctttgt cttttagaat aaaaaagaca tttgccagat     9540

gaaatttcag gccattttgt atactgaaat gaaggcttcg gggcagaagg acattttgga     9600

aaagggagtc tgtttccttc tatcttgctc agagtttgtt atcaaacaga taagagttca     9660

catctctgca gcatggttga ctagctgcat gacctgagaa aagttattta acttttattt     9720

tttgtcagcc tgtttctcag cttcaaaatg tagatattta tacccacctg tagatcagtt     9780

gtattagaag taacatggac aaagtactca gcctagctta ggcactcagt aaatgttagt     9840

ggttattatg tgacaagatc ataaagctaa tattggctaa gatttatgaa tgtaatcatt     9900

cagcatcaag gtgatcctag atgacatcac agagacttgg tgatctcagc ttttccttaa     9960

cacaggcctt tcaggtggtt cagtttattt attacggtca ctattttggt taattgtgtg    10020

tgcatgaccc gaactgacct tccagagaaa attgagtgag tagatttgct atcattattg    10080

taccatctct ttttgctttc ttttcttcct tcacttggca gtctttgtct tttatttatc    10140

ctgccatgcc tcatgtgggt aatgctgaat ctcattgtct atatgtcttt gtaataacca    10200

ggtctctcct tctgtgagat ttgtttcata aacatacatg attttcagtt tcaaagagat    10260

acagattagt ggttctcaac tttggctgca tattgcaatt tttggggaga ttttttaaat    10320

gcctgagtcc cagccccaga aagtctaagg tggcctggga agatgagtct cctcgccccc    10380

accccccccc aacacacaca cactcactca cctgctagat gcacacacaa atgtatgcct    10440

tagagaaggt atgcttttga gaaggcctgc tatgaaagag agacaggagc aaaactgaga    10500

cagaactaag aacaaatggc tctggagtat atttagaaaa taactcataa atgaagctgt    10560

ttaagttatc atgcttcata tgcctcaaag taaccttagt attcctgaag ttattctatt    10620

tccctaggtt agtgggtgaa acccctatag tttcagaatc tgggagtttt ccaaaaacat    10680

tccatatcca cacatctggg agggatgctt ccactccagc ttgaacctaa catacctttg    10740

gttataataa caggtgcttt gcagagcttt cttttttttt tttttttttt ttttgctaat    10800

cataacagta atgcatgcca caacagaaaa tacgttatat ttttattaat agattaaagg    10860

aaaaggatca catagtcttc ttaattgatg ctaaaatcat ttgataaagt ttaatttcca    10920

tttataattt taaattctta gaaaagttga aatagaaggg aataaatgtg gcacatatac    10980

accatggaat gctatgcagt cataaaaaag gatgagttca tgtcctttgc agggacatgg    11040

atgaagctgg aaaccatcat tctcagcaaa ctaacacaag aacagaaaac caaacaccgt    11100

atgttctcac tcataagtgg gagttgaaca atgagaacac atggacacag ggaggggaac    11160

acactggggc ctgttgaggg gtggggggct aggggaggga tagcattagg agaaatacct    11220

aatgtaaatg acgggttgaa gggtgcagca aaccaccatg gcacgggtac acctatgtaa    11280

caaaccggca cgttctgcac atgtacccca gaacttaaag tataataatt ttaaaaaggg    11340

gattgcatca ctctgataaa gggtattcat tgttttaaag tatcaagcgt catacttaat    11400

tgtgaacatg gaaagctttc cctttgagat caaaagaaaa aaaaaccaaa gatgtctgtt    11460

cttctcagtt ccactttgta aaggaggtct cagccagcat agtaaagcaa agaaaaaaaa    11520

agtgcaagaa gaaaaaagta ccgaagatgt aatttacaga taataagatt gtatacataa    11580

aatatccaac ataacctaga gataaacagt aagaattaat aaaagagtat agtaaggtag    11640

ctgggtacaa attaacatac ataaatcaat tgtgtataga cactagcaac aaacagaaaa    11700

tagtttttaa aaataccatt tacactggca ttttaaaatg tcaagtatct aggaataaga    11760

ttatcaaagt ataagtgaga tctctataag gaaaattata ataagtattg tgtaaagttt    11820

ttaaagaaaa ccaaatcagt ggggagacat gttctcagat tcaaagtctc aatattgtaa    11880

agactcccaa aaatgattaa taaatttaat atgatcctca aatcaatatt tcaacaggct    11940

tcttttggta ttacttgaca aactttaaac tttaaatttt cttcctcaaa agtttacatg    12000

aaattttaaa gagcaaatta tagccaagaa acttttgagg aagaaataca aagtgggaga    12060

actcattcta ctggatgtcg agatttacta taaagctcta attgaagcag tgtgccattg    12120

gtgtaagatt ggtcagaata atgtaacagc atagacagtc cataaacaga ccaacacata    12180

tgtaaacatc taatgtgtga aaaggtggca ccccagaaca gcagggaaaa ggcggtcttc    12240

aaaaaatgat gctgaagaat taggaatctc actggaaaaa ctacattaaa catccaactt    12300

tgcaccacac acaagaatca attctaggtg gatcaacacc tcacttgctt tgtgaaatgc    12360

aaatatataa agcccttttt taaattttac tttaagttct ggggtacatg tgcagaaagt    12420

gcaggtttgt tacataggta tacacatgtc atggtggttt gctgcaccca tcaacccatc    12480

atctacatta ggtatttctc ctaatgctat ccctccccta gcccccaacc cctcaacagg    12540

ccctggtgtg tgatgtcccc ctccctgtat ccacgtgctc tcattgttca tctcccacct    12600

atgagtgaga acatgcggtg tttggttttc tgttcttatg tcagtttgct gagaatgatg    12660

gtttccagct tcatccatgt ccctgcaaag aacatgaact cacccttttt tatggctgca    12720

tagtattcca tggtgtatat gtgccatatt ttctttatcc agtctatcac tgatgggcgt    12780

ttgggttagt tccaagtctt tgctattgtc aatagtgcca caataaacat acgcatgctt    12840

gtatctttat agtagaataa tttataatcc tttgggtata tacccagtaa tggaattgct    12900

gggtcaaatg gtgtttctgg ttctagatcc ttgaggaatc accacactgt cttccacaat    12960

ggttgaacta atttacactc ccaccaacag tgtaaaagca ttcctatctc tccacatcct    13020

ctccagcatc tgttgtttcc tgacttttta atgatctcca ttctaactgg tatgagactc    13080

catctcattg tggttttgac tggcatttct ctaatgacca gtgatgatga gctttttatc    13140

atatgtttat tggctgcata aatgtcttct tttgagaagt gtctgttcat atcctttgcc    13200

cactttttga tggagttgtt ttttcttgta aatttgttta agttttttgt agattctgga    13260

tattagccct ttgtcagatt gatagattgc aaaaattttc tcccattctg taggttacct    13320

attcactctg atgatagttt cttttgctgt gcagaagctc tttagtttaa ttggattcca    13380

tttgtcaatt ttggcttttg tcaccattgc ttttgatgtg ttagtcataa agcctttgcc    13440

catgcctatg tcctgaaggg tattgcctag gttttcttct agggttttta tggttttagg    13500

tcttatgttt aagtctttaa tctatcttga gttaattttt gtgtaaggta taaggaaggg    13560

atctagtttc aattttctgc ctaaggctag ccagttttcc ccacaccatt tattaaatag    13620

ggaatccttt ccccattgct tgcttttgtc aagtttgtca aagatcagat ggttgtagat    13680

atgcggtgtt acttctgagg cctctgttct gttccattgg tctagatatc tgttttggta    13740

ccagtacctc gctgttttgg ttactgtagc tttgtagtat agcttgaagt caggtagcgt    13800

gatgcctcca actttcttct ttttgcttag aattgtcttg actatgcggg ctcttttttg    13860

ttccacatga aatttaaagt agatttttct aattctgtga agaaagtcag tggtagcttg    13920

atggggataa cattgaatct ataaattact ttgggcagta tggccatttt cacaatattg    13980

atttttccta tccatgagca tggaatgttt ttccatttat ttgtgtcctc tcttatttcc    14040

ttgagcagtg atttttagtt ctccttgaag aggtccttca catcccttgt aagttgtatt    14100

tctagatatt ttattctctt tgttgcaatt gtgaatggga gttcactcat gatttggctc    14160

tcggtttgtc tgttattggt gtatgggaat gcttgtgatt tttgcacatt gattttgtat    14220

cctgagactt tgctgaagtt gcttatcagc ttaaggagat tttgggctga gatgatgggg    14280

ttttctaaat atacagtcat gtcatctgca aacagagaca atttgacttc ctcttttcct    14340

atttgaatac cccttatttc tttctcttgc ctgatcgccc tggccagaac ttccaatact    14400

atgttgaata agagtggtga gatagggcat tcttgtcttg tgctggtttt caaaggaaat    14460

gcttccagtt tttgcccatt cagtatgata ttggctgggg gcttgtcata aatagttctt    14520

attattttga gatacattcc atcaatacct agtttattga gagcttttag catgaatggg    14580

tgttgaattt tgtcgaagac cttttctgca tctattgaga taatcacgtg gtttttgtca    14640

ttggttctgt ttgtgtgatg gattacgttt attgacttgc gtatgttgaa ccagctttga    14700

tcccaggtat gaagccgact tgatcgtggt ggataagctt tttgaaagga aaaaacaaag    14760

aggaatatct ttatgacctc agactaagaa aaactttatt acatatgaca caagaagcac    14820

taactataca ggaaaaaact gatacatttt agtatactat aattaagaat gttcatcaga    14880

agacaacttt aagagcatga aaaagcaagt gcttatattc agagtaatga actctacaaa    14940

tcaattagaa aaatgtcaga acaaccactt gtaaaatagc acaaaatttg aataggcact    15000

ttacaaaagt ggaaatccaa atggccataa acatatgaaa gtattcttaa ccttttttta    15060

aatcaaagag ttgcaaatta aaatcacact gagattttat tacatgttca tcatagaagg    15120

gaaatttttt aaagtgtcac aataccaagt attgggaatg acatggagca acagaaactc    15180

acacactgct ggtgggagtg taaatttgga caacctcttt ggaaagcaag gggtattatc    15240

tagtaaaggt gtaagcatac atatgctgta ttcttctatt acacccttag gtacctatgt    15300

ttaacagaaa tatgtacttg tggacaccag attacagcta caagaaagtt tatgaacatt    15360

tgcccataaa aaccccaaac cggaaaccac tcaaatgtcc ataaactttg agtacattaa    15420

ctatttctgt tatattctaa aatgagaaaa cttacagcaa taaaaattaa taaactttag    15480

tgctgcacaa caataaggat gagtcttaag aaagtaatat tgaacaaaaa aagccaaatg    15540

caaaggatta cataaacaag gttcatttat ataaagtttg aaatcaagca aaactaaact    15600

attttgttta ggaatgcata cttatgaagt aaaaagcatc aataaagtaa ggcaagaaaa    15660

agtaccaaaa attaggagaa tagtggcctc cagggcagaa gagggaggat gtaattggga    15720

aggagctggt gaagtgctgg tcacgttcca ttttatggca tgggtagttg tcacacaagc    15780

tgctatggag tgaattttgt cccctcaaaa ttcaaatgtt gaaacaaacc ccccatgttg    15840

ctatgttgga gattgggcct ctaaggaggt gattgggtta aatgaagtca caagagtaga    15900

gcccttaagt ggtagaactg gtgtccttat aagagaaaga gacagctttc tcccctttgt    15960

gtgagaacac aaggacaagg tagacatcta taagctagaa agagagtctt tcccagaccc    16020

aactatgctg acatcccaat ctcaggcttc aacctccaga tttgtgagaa aataaatttc    16080

tgttgcataa gccacccagt ctatggtatt ttgttaaggc aacaaaggct gactaataca    16140

caaacatttg ttttaaaata attaatttat gttttatgta catttttatt atgcatgtta    16200

catatcataa taaaaaccca ataatttttt aaaataaatg accattgcaa aaaatgcaga    16260

acactgaaaa tataaatcag aagatggtta ctaagtagag aaatcacaaa atcatgaaat    16320

tatatttaat attgttgaga tcatatagca tgtaaaatgt ctatgcttct tttggagttt    16380

taatgtaaaa catttttttg caaaatgagt tatttgggag ttatttggag attgtggtta    16440

aatatggaag atagaatgca tatgttttac cccaccctct caaaatgcca atagaatgac    16500

agcacggggg aaagaacagt ataaatatac aagaacaaag agaaagagaa tggaaaacac    16560

agaggacaaa tgatgtcaaa acacttggaa gaccaaaagt gggtggagaa gtggtaaatc    16620

acttagcaga tcagggtttg ttaaaccacg gtgcctccag agggggataa aaatgagaat    16680

aaaggcattt taccgccccc gctgcccaac aagccccaga ggccctgcaa gtgttgacat    16740

gatacaaata gcaagaaatg gaagcagaaa gaggaaagaa catgtgagca gagtatgttc    16800

acttactgct gcttctataa taacaagaag ttaaagagta ttatttaaag ttgacaaata    16860

aagaaatgga caaaataatt acacttgaca gtacaaaggt aagcacaaaa agatattatt    16920

aaatacagtc agataatgga taaaacagag aggaaaggaa tcaccaaatg gaaatgagag    16980

attttgatta aagaaatagt acactaagga caatgtatta cacggtttta attataatta    17040

taaatttata ataagttttt acttataaag acaaccacta ggataaagat acaaactctt    17100

tagtaatcta tatatttgta acaaataata tgacaaactc taaatactgg aagaattgta    17160

catcaaaaaa taaaaagcaa ataagagatg ccaaataatg aaaaggtaca aaagtaattg    17220

gggtttcaga ccataaatat taaatcatta taactaggct caaacacatc tttattaatc    17280

aaagtaggaa ccattacaat caacacattt ttgccaatga gaaatgagtt tgtttattcc    17340

tgtagcataa aaatccatgc tttgggattc aatgaactct tggaaggcat tttctgcatc    17400

ccgctggtta tggaagtgtt tcacctgcaa aaagttgttc agatgcttga agaagtggta    17460

gttggttggt gagaggtcag gtgaatatgg tggatgaggc aaaacttcat agcccaattc    17520

attcaacttt tgaagtaact gttggttgtg tgacatgcag tcggttgttg tggagaagaa    17580

ttgggccctt tctgttgacc aatgccagct gcaggccttg cagttttctg tgcatctcat    17640

cgatttgctg aacatatttc tcagatgtaa tggctttgct gggattcaga aagctgtagt    17700

agatcagacc ggcagcagac caccaagcag tgaccacgac tttttttggt gcaagttggg    17760

ttttgggaag tgctttggag cttcttctca gtccagccac caagctggtc attgccagtt    17820

gtcaagtaaa attcactttt tatcgcacat cacaatctga ttaagaaata gttcattttt    17880

gttgcataga ataagagacg acaacacttc aaaatgacga ttttttaaac atttttcctt    17940

agcttatgag gcacccattt atggagctgt ttcacctttc caatttgctt caactgccga    18000

atgaccgtag aatggtcaac gatgagttct tcctcagctt cttgtgcagt tgtaagagga    18060

tcaacttcga tgattgctct caattggtca ttgtcaactt ccaatggcca gccactactc    18120

tcctcatctt caaggttctc atctcctttg caaaacttct tgaaccacca ctgcactgta    18180

cctttgttag caatccctgg gccaaatgcg ttgttgatgt tgagttgtct ctgctgcttt    18240

acaacccatt ttgaactcaa ataagaaaat cgctcgaatt tgctttttgt ataacataat    18300

ttccatagtc taaaataaat ataaaataaa cagcaagtaa taagtcatta gcaaaaaaaa    18360

aagtgagaaa tgcacattaa aatgatgtat aacatggtca catttattta agaatgtatt    18420

ccaatatcaa acggcaaatt tcaacaatgc aaaaaccaca attacttttg taccaaccta    18480

atattttaaa aactaaatac gtcatatgaa ataatataaa caagctaaga ctaagcaaat    18540

ctgtcatgtc actaaatata aatggatttt actcacctat ttttaaaaat gcctattaca    18600

ttacaaagca atacccaact ctatgttgaa taaaaaaaat actcctcacg gtgatacaga    18660

aaggctaaaa ttatagaatt caaaagacat aagcaaaggc aaacaaagaa agcaggatcc    18720

atgattttaa tatcagagaa agtggaatct cggtcaaaaa gcatgaaata ggacaaaaat    18780

tgcacagaca tattaatatt aaagacgata gtaatctata tctttgcaac aaataagatg    18840

gcaacaatat ttataaatca gaaattatta gagtaggagg ataaataaaa acattgtagg    18900

aatagaaatt ttcaattaat tttagccaat aacagatcaa atgtattaaa aagtatgtaa    18960

aattatagat gacctagtaa tataattaat ataatgtatc tgattaatat atagcaaact    19020

accttcccta acaatagaaa atgcacctcc ttttcaaaaa accaaacata tcaaaccaaa    19080

tattaagcca tgacaaaaac ctcaataagc tccagaaagt ggaaataata tagaaaacat    19140

tctctgatca taatgaaata gagttaaaaa aaataaccaa atttaatgaa atgagaggac    19200

tttccacttg ataattttta aaaatctctc ttaaagaatt cttggacaaa agacaaacta    19260

taaactaaaa ttatataatt tcgagggaag gaaagataaa aaacagttta atcagaacct    19320

agagagtgca gttaaagaca tacatattca gggaataagt cacagcatgg aagcatagaa    19380

tatttatatc agtaaaagct gaaaagaaat tatttaaaga cctaacaaaa ctagaaaaag    19440

gataacaaat gaaagaaaga agttaataat tataaaaagc aataaattac aaaatagaaa    19500

aacagtagat ctaataaatc caaatgctgt tgtaaaaata tgcacaagac ctttatacta    19560

aaaaataata cagcattatt gagagaaatt ttaaagtacc taaatgaatt aaaggatgtc    19620

tcatgtgact ggattagaag attcataatt gttagaatgt cagtgctgcc caaattagtc    19680

tataaattca atgacatccc caaaaaaatc ccagcagcag ctgttttata gaaattagct    19740

gaacagattt catttgcatg gatgaagtga agtttattta actattttcc tattgataga    19800

cattcacatt tatcataatt aacataatcc tcatattttg ccaccacata ttaatttttt    19860

ggtgagtatc cttacacatg tatctttgta cacataatat gagtaaaatt aaggatgaat    19920

ttctagaagt agaattgcca ggtcaaaggg gtgtacattt taatttttga gatattgcca    19980

aatcgtcttc caaagttgga tcctttccat tcccagtaat tatcaaatcc attctttagg    20040

agattttgta ttaactgaac tgttgacata attcccttta tatgcacact atgaaaagta    20100

taacatatac aaatctacct atatggtcac aatcctggga atttatgtga caggtattgg    20160

atgatgttca gcatccttgg cctcgtggaa ataatcagac tagattttct ttttgaaatg    20220

caaattgata atagccatta gttgtttcct atgttgctga gaacccagag gaagataata    20280

aatgtccttg ggatagactg gggctccaaa gatcatgctg tatacttttg aaaaagcatt    20340

aaattgtagc cagtgaggaa tcagaaacca atcttattgc catgttctta acacaatctt    20400

tttccttatc ttccctccct tccattattc cttgctgaaa cattagcttt gcacaattac    20460

ctgctgataa tggtagctct atgtctttct gcgtgcctgc ctatctgtct gcttgtggaa    20520

agataaagat agatattcca ttttctaatc ccctcttttg cttgggaaga aactagaggt    20580

tcttcctcag attgggcacc agaaggtaaa gagagcaggg ggtcaaaaat tgttaagaag    20640

ggcaagacta gaactttcct actctcccca tgccctggtt tcagagaatc attgaagggg    20700

ctctttgatg accctaggac actcacctct aagcataaca atattctgga aaacctttga    20760

caaattatag caatttggtt gtagagaaga taaatgtttt ctcacctggc aaagaacatg    20820

tgaaatgaag ctgaatctac tgcaaacggg gaagtgggtg tttaacactg catgcataaa    20880

gtattgattt gtatcttttc aaatttatgg aactgttatc attttatatg tgtgctttat    20940

ctgatgtttt aaaattatgt ttttgggatt tgcccaaatg gatacatgta gacctaattc    21000

attcattttt tattgccata tagtattcca taaagatatt atcctgtgtt ttctcctcaa    21060

agttacagtt ttcctttcta catttaggta tttcaatctc ctagaattta tttttgtatg    21120

tgtgtggtat gagataggct tccaatattt ttccatatgg attattccaa catttttttc    21180

aatacatcat ttcccaagtg gttcctacca ctgcttctgc catgcaccag attcccatgt    21240

ctactgaatc tgtttctccc agtaatctca ttgtcacatc ctgagtcaac accacgtgga    21300

tttaaatgct ctatagtaag atttgacctg gtcgattcac atgcccctcc ttatttgtct    21360

tcttgaaaat tattttggtt cttgtttctt tacttttcca tatcagttta agggtcacat    21420

tttccagctc ttttcttaca actctgtgga aactttgttt ggtaatgcac tgaattgatt    21480

tatcaccaca ggaagaatcg ccacatttac aatacgaagc cttcccacac atcagtatgg    21540

cagatctctt aatttataca ggtcttcttt aatatttttc tacattttat aatgtctttt    21600

tcctaggtac attgcaattt tggttgccct attgaatact tattattgct aaactgtctt    21660

aatattatta atttctatat agtgattttg catccagcaa ccctgctgag ctccttaaag    21720

ttaaattttt ctgtagattc ccttggactt cctatttaga cagttatatt atctgcaaat    21780

aatgacaaac ttgtttcttc ctttatgatt cttataccac ttttttattt ttcctgtctt    21840

attgaattgg ccgggacctt caacaagatg gtaattcaaa gctatgacag tgagcatatt    21900

tattttgctc ttgattttaa agtgtgtgct tctaatgttt cactattatg atgtttatga    21960

gagtctcata attacttttt atatcaattt tttccatttc ttgtttgttg agactttcat    22020

catgaatggg tgttggcttc tatcagtatt tttatattta ttgaggttat catatagtct    22080

ttcatctgtt agtatagtaa atctgtaaac taacaggttt gttagtctat ttttaatggt    22140

tccagctgat cattttgctg gattcaatta ggtgtatttc attttatcta ttttgctaaa    22200

tgaggctggc ctgtaatctt ctttcataaa ctgtcccttt gggatgttcc aactctctcc    22260

tcaattgtcc ctgggaactc caacttattc ttactttgtt tagcagagca attcatctct    22320

ctccatctcc tacaatgttt ctcaacaagt gatctaagga tctctatgca catataattt    22380

taaaatctaa catgtaagat taattattat attcatagaa tttctaactt tttatgtttt    22440

caaaaacagt gtatgtgctt caaaaactga tttcattcat aatggttaac atggagttaa    22500

tcataggcag tttatcttga ctaatgtatt ttattgtcac ctgacagtta tttacacttg    22560

tcagacttgc atttgccatt attactgtcg ctttgcataa tatcacaatt caaaaaaaag    22620

agtcatcact tcgaaagtgg ttttctgaag cataacaata atgataaaaa tagaaatata    22680

aatcctacaa tgtgaaataa ggtcacaatg taagtaatga atggcctcca ttgtaaaaat    22740

acaaagcatg aatctgtttg tcatgagaca agtggataat ggatgtggat aatctcccaa    22800

aaccagacaa aaatatataa gaaaatggga gccatgacaa tgaataatga taattgaatt    22860

ttattggacc aatgatcctt ttgtcctagt acccaattta ttatctgcta acgtttttgt    22920

caagtaatga tataaagcta tcaaaacttc catattattt tccaataaag tttatcaacc    22980

ccacttttaa accaattgaa tatctctact acaagcacaa aataaggctt tcccagtata    23040

aaattgtgaa aattttatgt taaaggttga gaagacaaca aaactataga gtcatcattc    23100

atcctcatat caaaaataag cacaattgca ctcctgctgg taagatacaa aaccagtttc    23160

caaatcaatt acaaatattg tggttggaga agaaacaaga aaaacaattg gtataattcc    23220

ttaattagaa gtattgcatt ccttataatg tgactggcat ttaaagtcaa tgactgttag    23280

gtatacgagc agacatttta ttttatagtt gaacaaaact atgaataagt aagttgtcag    23340

catatcttca ctatatatat gggaaagact cagtgacttt ttgttctatt tatcatgaag    23400

ctaattttaa aagaagagct ctctggttta attaaaaatt agtttgaacc tatgaaacag    23460

actttaaaag gtatgttggc ttatgcacta atgtttgtag cagcgttatt cacaatagcc    23520

aaatatgtcc atcaacagat gaatggataa aaaatgtagt atatatgtaa acaattgaat    23580

atcattcagt tttaaaaatg aatgagattc tgatacatgc cacaacattg acaaagcatt    23640

gtgctaagta aaataactca aacgcaaaag aacaaatgtt gcatgattcc acctttagta    23700

ggtacctaga acaggcaaat tcatggagac agaaagtaga atggaagttg ccagagaggg    23760

ggaatgggga gttattattt aatgggtaca tttctgttcg ggattataaa aaagtttgga    23820

aacagatagt ggtgatagtt ccacaatact gaatgtactt aatgccacta aattgtgtac    23880

ttaaaaatgg tgaaagtggt aaattttatg ttatgtatat tatgcatatt ttaccaaaac    23940

ttttttttaa aagaggaaag gtgttaaatt gccattgaag aaactccagc cacatggtca    24000

gcaaggaaag gtatcactat ccagatagaa gatgctgctc ccagatccca atgctagtgc    24060

ataccttatt cacggaacgc agctgggggt ctgtaatatg cctccagatt ctgatttgct    24120

gttgaggtac acagtggaaa ttgtgaatac aaactgattg tggtcactta gtgtacatct    24180

ctttggccta ctgggctgaa atgaaaagtg agtaagagag gctgctctcc cacactgaat    24240

tgctttggct ggcaaatggg aagggcttac acagagtttt aaaaataagg aatgaaatgt    24300

tttaaattac catttttatg aatacaagtt gggtatctca gtgatccatt cagaatttga    24360

atattatgaa tctttgtttt cagagcctga atatcgggat ttgtaacaat cagacatcag    24420

tggtgcaagt ggctcaacgg ctgagaactt gactttttcc caatacccaa tgattttctt    24480

cattcaccag aaaaagcact taggaaataa cacattgggc ttattaaaaa ttacatctga    24540

atgctgcaac ccaacatcaa gaaatacctt gcagagccaa ataccaccaa agagaggatg    24600

caactccatt agctgctgtt gagctggggc acttgccttc tggtgaagca ctgaaaatag    24660

tctttagaga gcactctctc cataatttct gggtctgtgt ttgatttgac aaaccagaaa    24720

tatccatcaa agcttcccaa caacctataa ttctgagtta agattttcta atttagaaaa    24780

cataaagagt gtggggggga aaccaacaag atatggaagc tgacagctca agcagctatg    24840

caaccagata tagattccta aatgatttca aacacgattt ctcctctcac agatgtgaaa    24900

aaaaattatt cactttttaa cttgactttt acttttattt aagacatata tgttcataat    24960

ttaaaaggtc acagagtttt ataaagattc tgacaaaaaa aacagcaatt tcatttttct    25020

catctcttct ttccagaggc caccactttt agcttttttt acctgtgtct tctgatacct    25080

ccctatctcc aataatatac tcataatact aatttttaat ttttcaattt ctgatgttat    25140

ttattggctt cctattatga gaaaaaactt aaggccacat ccacaaactc atttcctctc    25200

accctcatct tcctgttaca gttatattgt aatcttcagt tagatcatca gataatatat    25260

ccattgtatg actacatata taattacatt acattgctaa gtaaacactg tttacagctg    25320

tgtcatgcag tgtactttga ctatatttcc tttttgcaca atgtttttgc tttccttgga    25380

gttaataagg attttatttt tttgtttgct cagttttcta tttatcccta atttgttccc    25440

aaactcttct ccagatgttt aattgttgct tcaatttatt tgcacacatc aggtgcatgt    25500

gtatcatttt tttcctatgg gaatcacagc tagagtactt catcttctgc ctcattctga    25560

cctagatgtt ttctaggcct gatgcacagc tgttttctag agattttttc ttcttcattc    25620

tttttttgga ttccttttgc ctcttccctg gatcgcatat atgtttcttg tttgaatgga    25680

gcatatcctc tagtaacatt tttttttaag acaaagtctc tctatgctgc ccaggctgtt    25740

ggcctcaaac tcctgggttc aagtgatcct cctgcctcaa cctcccaagt agttaggact    25800

acaggtacat accaccatgc ccagcttcta gtaactttat tagaagggta actaagaagt    25860

acatttccca agacttcata tattctacct tctttgacag tttggctagg gaaagacttc    25920

tgtattagaa attatttccc tcttaatttt gaaggccttg ctcattgtct tctaatttct    25980

ttctagacct cctattagtc aaacaatata cctcctagtc tgattctcta attttcaaac    26040

tttttatcac ttcctatcca tttctgcttt tttgttccac ttcctgtgag atttccaaaa    26100

ctttatttac aagtccgcct attagtgttt tacttttgct atcatatttt tgttttcaaa    26160

attccatttt gtctttgaag gtacttttta catccttctg ctcttgttct atacgtggag    26220

cctcttctca cctcttaact ctctaaaaat attagtacag gttttttttt ttttgttttt    26280

gtttttgttg ttgttgttgt tgctgttgtt gttgttgttt tggagacgaa gtcttgctct    26340

gtcacccaga ctggagtgca gtgacgcgat ctaggctcac tgcaagctcc gcctcccggg    26400

ttcacgccat tctcccgcct cagcctccgg agtagctgga actacaggtg cccgccaagg    26460

cgcccggcta attttttgta tttttagtag agacggggtt tcaccgcgtt agccaggatg    26520

gtctcgatct cctgacctcg taatctgccc gcctcggcct cccaaagtgc tgcgattaca    26580

ggcgtgagcc acagcgcctg gccaatacag ttttatttct ctaactcttc ttctgccctc    26640

tttattgtct ctttttcttt tcttttcttt tctttttttt ttttttttca gttgtttggt    26700

tgctttggtt tctggtgtta gaagcatcct tcaaattcct gatgctcctt ggctggctgt    26760

tcatgttaaa agtgcagcat cttcatgggc tctaaaccag attatcttct ggaaacttaa    26820

cgaggagcag aagtgaatag ggaggggagt tgtttgcctt tcagtaggta aacttttctt    26880

tatatgcatt tttcagtatg caactgtttc cctcttcttc aactcttaag aaaatgagca    26940

tccaatccat ttctggagca gaaacagttt ctcattgaat ggatggcata aagcagcatc    27000

tagaaagctc aactggttcc tgtaaaaaac tttcaagcaa ttctttcagc cctacttatc    27060

accctccccc aaaccttgct ttcagagata cttagcatct ctaagttcca agcagttctg    27120

gggctctgca gcatagcttg gcttgcttct gggtattccc tgcttcagcc agttttcagc    27180

tttcttaggt ctgctctgtc agttaccact catcagtctg cactccagtt tctaaaaact    27240

gggagttttt agatgagcct ccagcttctt gcaggatagg gaggccctgg cagacataaa    27300

caggagaatc cttgctcttc acccgctact gccctctgcc taaccccaga acagcagaag    27360

ctgctggctg tcccagccac acacatccct ccccactcca tctatttgtg tggcccttct    27420

ttttccctca gtctgtgtct tgtttcctct ccttaccttc ttccccctca tcaccttggt    27480

gatattcttt gcatgttttt tcttggagca gtcagagcag gtcatccctc cctcctggaa    27540

gaaggaaccc cctgagtaca ctccatggca cagttgacac tccttttcta ccctccttcc    27600

cagatatgtc ttcactgtca tttacacctt tgaagccttg ataaagatac tggcaagagg    27660

attttgtcta aatgagttca cgtacctgag agatccttgg aactggctgg attttagcgt    27720

cattaccctg gcgtgagtat atctctatgc agatctgcat gtgtgatagg agaggggaca    27780

aaatggtggg taggagacag ggctaacatg caggtcccac ttggacagag tgtggagact    27840

cacaccatga acgtttgctc caagaaccac tgcaggaata taccaggaga actgaaagaa    27900

ttcatagatc cttttaaata agtggcacac tgctggaaat tctgcaagac aggtgaaaaa    27960

ctgtgagctc ccaaagtgtg agggggggaa acctgcctcc aaacatacat cccaactggg    28020

taatctgaaa atccagatca caggagaaga atttaccctt acctggaatg taaataaatt    28080

taggaagcca cacaaaatat aaaagtagaa acagcaaagg gaagtgcctt gtaggcactc    28140

ccagtctcca gcttgagacc agggaatcca tccctgacta tgtctcacag gcacccttgg    28200

ggaaggcagc cagtggaatc agggaggggt cacaggatga aagaagtttc aactaaaatt    28260

agtaataatt tcaactgggc acaaattttc ttgagcagaa tccagggggc aaatgggaac    28320

tgcaagcaga cagtgaggga tgcggtccaa aagtcatgct ttctttctca gtggggaagc    28380

tcacagcctg gggcaaggtc tgagtagggc actgcaggag caagaccagc ctcaccaact    28440

acatgagagc taggtgaggc ctctcactag cagctatccc ccacttccct ggagaactct    28500

atggcacagc agaggcagcc aaaattccct ctggaacaca accccactgg cctgagaacc    28560

aacccccatc caccacagtg gccacagcaa tccctaccca agaagggtct gagtctagac    28620

tcacctaccc ctgcccccac ctgatggtat ttccctacct gccttggtag ctgaacacaa    28680

aacccagaaa ctctcggaag ctttatggcc ctgctcatca cctaagaaac taaaatattt    28740

accctggcca acttagggtg agcttagatc ccccttctac taatgcacta gtgctctctt    28800

gaaagcatca cctaccggct ggaggtcaaa cagctcaggc cattaaagca actcatgaca    28860

gaataacttt gatcccagga aaaagaaaac aacaaccagt tgcactgcct gcaacatcct    28920

ggctaaccag acgtcctgag tctgtccata tgacaacttc actgctaaca taactagcat    28980

tcaagaaagc cagcacacta aatctatcta cagcctagga ctctcacaga ctctacttca    29040

ttcctctgcc accttcacca gaacagatgc tgatatccat ggctgggaga cttcaagatc    29100

aatcacatca caggactctt gcaggcattt cccagtacta ccccagagcc tggtagcccc    29160

tctgtgtggc taggcccaga agaacaataa cgatcactgc agtccagctc tcaggaagcc    29220

ccatccccag gggattgggg agagcaccac atcaagagat cacccatgaa acaaaagaat    29280

ctgcacaaca gccattcagt tccagatctt ttctctgaaa tagtctactc aaatgagaag    29340

gaaccagaaa agcaattctg gtaatatgac aaaagagggt tcaataacac ccctcaaaag    29400

atcaaactag ctccccaaca atggatccaa actaagaaga aatctctgaa ttgccagata    29460

aagaattcag ggctgggcac agtagctcac gcctgtaatc tcagcacttt gggaggccaa    29520

ggtgggcaga tcacctgagg tcagaagttc aagaccagcc tgaagccaac atggagaaac    29580

cccgtctcta ctaaaaaata caaaattagc tagatgtggt ggtgcatgcc tgtaatccca    29640

gctactcagg agactgaggc aggagaattg cttgaacctg ggaggcagag gttgcggtga    29700

gctgagatcg cgccattgca ctccagcctg ggcaacaaga gtgaaaatcc atctcaaaaa    29760

aaaaaaaaaa agaattcaga aggctgatta ttaagtgatt caaggagaca ccagagaaag    29820

ataaaaacca acttaaagaa atttttaaaa caacaagata tggatggaaa attctccaga    29880

gaaatagata taaagaaaaa acaatcacaa cttctggaaa tggaagactc acttagagaa    29940

atacaaaatg cagtggaaag tttcaacaat agactagaac aagtagaaga aagaacttca    30000

gagctcgaag acaaagcttt taatagaccc aaactaagac acacaaaaag aaagaatttt    30060

taaaaaaatg acaaatcggc caataaattt ggaatcatgt gaaacaacca aacctaagaa    30120

taatgggtgt tcccaaggaa gaatagaaat ctaaaagttt ggaaaactta tttgagggaa    30180

taattgagga aaacttccct ggccttgtta gaaatataga tatccaaata caagaagctc    30240

aaagaatacc tctgaaatgt gtcacaaaaa agatcatcac ctaggcaaat agacatcagg    30300

ttatctaaag tcaagacaaa gaaaagaatc ttaagagctg tgagacaaaa gcctcagata    30360

acctataaag gaaaggttat ctgatttaca taagattaac agcagatttc tcaactgaaa    30420

ccttgcaagc cagaagggat tagggtccca tctttagcct cctgaaacaa aataattgcc    30480

agccaagaat attgtatgaa gagaaactaa gcttcataag tgaagacaag ataaagtttt    30540

tttcagacaa acaaatggtg agagaatttt ccactaccaa gccagcacta caagaaatgc    30600

taaaaggaat tctaaatctt gaaataaaac cttaaaatac accaaaatag aacctcctta    30660

aagcataaat atcaaaggac ctataaaaca ataacacaat aaaaaaagga attaaggcaa    30720

taactagcat aatgaataga agagtacctc acatctcaat actgatgttg agtgtaaatg    30780

ccctaaatga tccacttaaa atatacagaa gggcagaaag gaaaaaaaaa atccaccaac    30840

caagtatcta ctgtcttcaa gagactcacc taacacataa ggagccacat aaacttaagg    30900

taaagagatg ggaaaagata ttccatgcaa atggaaacca aaagcaagca ggagtagcta    30960

ttcttatatc agagaaaaca gaccttaaag caacaacagt taaaaaaaga caaagaggga    31020

catatataat gataaaataa ttggtctaat ggaaaaatat cataatccta aatacatatg    31080

cacctaacac tggagctccc aaatttataa aacaattact actagaccta agaaatgaaa    31140

tagacagcaa tataataata gtgggggatc aatattccac tgacagcact agacaggtca    31200

tcaagacaga aagtcaacaa agaaacaatg aacttaaact gtaacctaga acaaatggac    31260

ttaacagata tttaaaaaac attctaccaa acaactgcag aatatacatt cttttcatca    31320

gcacatggaa tattctctaa gatagaccac gtgatagata acataacaaa tctcaataaa    31380

tttaagaaaa tagaaattat gtcaggtatc ctctcagagc acagtcgaat aaacctcgga    31440

gttaactcca aaagaaaccc tcaaaactat acaaatacat gaaaactaaa caatctgctc    31500

ttgaatgatc tttgggtcaa caatgaaatc aagatggaag tttaaaaatt ttttgaactg    31560

aatgataata gtcacacaac ttatcaaaac ctctgggata cagctaaagc agtgctaaga    31620

ggaaagctca tagcattaaa tacctacatc aaaaagtatg aaagaggaca aatagataat    31680

ctaaggtcac acctcaagga attagagaaa caagaacaaa acagacccaa accaagcaga    31740

agaaaaggaa taacaaagat cagggcagta ctaaatgaaa ttcaaataaa aataataata    31800

atacaaaaga taagtgaaac aaaaagcggg ttctttaaaa agatatagaa aattgattga    31860

ccattggcaa gattaaccaa gaaaagaaga gagaagatcc aaataagctc aattagaaat    31920

aaaatgggag atattacaac tgataccaca gaaatacaaa aaaaaaatca ttcaaggcta    31980

ctatgaacac ctttatttgc acaaactaga aaatttagag gagatgaata aattcctgga    32040

aatatacaac tgtcttagat taaatcagaa agtaatagaa actctaaaca gaccaataac    32100

aagtagcgag attgaaacag taattcaaaa attgccaagg aaaaaaagtc caggagcaga    32160

ctggattcac agctgaattc tatcagacat tcaaagaaga attggtacca attttattga    32220

aactattcca aaagatgcag aaagagggaa tcctcctaaa tcattttatg aagccagtat    32280

caccctaata ccaaaaccag aaaaggactt ttaaaaaaga actacagaca atatccctga    32340

tgaacataga tgcaaaaatc ctcaacaaaa tgctagctaa ttgaatccaa cacatatcca    32400

aaagataaca caccatgatc aagggggttt cataccaggg aggtagggat gatttaacat    32460

acacaagtca ataaatgctg cacgtcacat aaacagaatt aaaaacaaaa atcatatgat    32520

catctcaata ggtgcaggaa aagcatttga caaaatccag catcccatta tgattaaaac    32580

cctcaaccaa attggcatag aagggacata ctccaaggta ataaaagcca tctatgacaa    32640

atccacagcc aacattatac caaacaggga aaagttgaaa gcattccccc tgagaactga    32700

aacaagacaa ggatgcccac tttcaccatt tctatccaac atagtactgg aagtcctagc    32760

cagagcaatc agacaagaga aataaataaa gggaatccaa atcagtaaag gggaagtcaa    32820

actgttgctg ttcaccaatg atatgatcgt atgcctagga aaccctaaag actcatccaa    32880

aaagctccta gatctaataa atgaattcag taaagtttca ggatacaaaa acaatgtata    32940

caaatcagca gcactactgt acaccaccag aaaccaagct gaggaacaaa tcaagaactc    33000

aatccctttt acaacagctg caaaaaaaaa acaaaaataa aaacaaaaaa atcttaggaa    33060

tatacctaac caaaaaggtg aaagatttct acaaggaaaa ctacaaaaca ctgctaaaat    33120

aaatcacaga tgacacaaac aaatgggaac acatcccatg ctcatggatg gataaaatca    33180

atattgtgaa aatgacctta ctgccaaaag caatatacag attcaataca atttccattg    33240

aagtaccaca tcattcttca cagaaataga aataacaacc ctaaaattca tagggaacca    33300

aaaaggaatc cacatagcca aagcaagact aagcaagaat aacaaatctg gaggcatcac    33360

cttagctgat ttcaaactat actacaaggc tatagtatag cctgtaccaa aacagcatga    33420

tactggtata aaaataagca catagaccaa tggaaaagaa tagagaactc agaaataaag    33480

ccaaatactt acaagcaact gatctttgaa aaagcaaaca aaaacgtaag tggggaaagg    33540

acaccctatt caacaaatgg tgctgggata attagcaagc cacatgtgga agaaagaaac    33600

tgaatcttca tctctcacct tatacaaaaa tcaattcaag atggataaaa ggcttaaatc    33660

taagacctga aattataaaa aattctagaa gataacattg gaaaaactct tctagacatt    33720

ggcttaggca aaacgttcct gaccaaggac ccaaagcaaa tccaacaaaa acaaaaataa    33780

atagatggga tctaattaaa ctaaaaagct gttgcacagc aagagaaata atcatccaag    33840

taaacagaca acccatagga tgagagaaaa atctttgtta tctatgcttc cagcaaaaga    33900

ctaatatcca gcatctataa gaaacacaaa taaatcagca agaaaacaaa caaataatcc    33960

catccaaaag tgggcaaagg acaagaatac gcaattctca aaagaagata tataaatggc    34020

caatgaacag gaaaaaaaaa tgctcaacat cattaattat cagggaaatg caaattaaaa    34080

ccacaatgag ataccacctt actcctgcaa gaatggccat aaccaaaaaa taatagatgt    34140

tggcatggat gtaatgaaaa ggaaacaatt ttacactgct ggtgggaatg taaactagta    34200

caaccactaa ggaaaacgtt atggagattc cttaaagaac taaaagtaga actaccattt    34260

ggtccagcaa tcccactact gggtatctac ccagaggaaa ataagccatt attaaaaaga    34320

cacttgcata tgcatgctta tagcagcaca gtttacaact gcaaaaatat ggaaccagcc    34380

taaatgccca tcaaccaaca agtgcataaa gaaaatatgg tgtatgcata ccatggaata    34440

ctactcagtt gtaaaaagga atgaaataat ggcattggca gcaagctgga tggagttgga    34500

gactattatt ctaaatgaag taactcagga atagaaagtc aagcatcatg tgttcttaat    34560

tacaagcagg agctaagctg tgaggatgca aaggcataac aatgacataa tggactttgg    34620

ggacttggga ggaaaggtga gacgaaggta agggataaga gactacacac tgggtacagt    34680

gtacactgct cgggtgatgg tgcaccaaaa tctcagaaat cagcgttaaa gaatttttct    34740

gtgcaaccca acaccacctg tttcccaaaa ctattgaaat acaaataaag aacttattca    34800

tgtaaccaaa aaccacctgt tccctcaaaa ctattgaaat aaaataaaat aaaaagattt    34860

gcatgggtgt ccatgtgggg cttatgggtg tatccaggct cacactctga agaaggttct    34920

tcatctcagt tcagcttcct catttggaat tgtatggcct ggggttcttg ccacagagta    34980

ccgcttcggg ggttgctttc caagattagt cccatgccca tgaggagatg tcagagacct    35040

caaatctgag ataacagtta gcctgtcaca gtggatcaga aaaggcccag ccttgtaccc    35100

ccctgacatg gcggtctcct tctgagaaat cagtgtctga ggagactggt tggtcaaact    35160

cctgtgtttg aagatccgtc cacatgcagt gttgcctaga tcacaatgca tcttctcaaa    35220

gggtccactc tgaaagatgt tgcaataatg aaatcagtgt cagtgtcagt ctatagatgg    35280

cagtgtcact agattctaag tgtccattct gcatcctttc taggctaatg ataccccagg    35340

ttatccttat ttatgctgca tgcatcccca ggacccttgc ttgcagagat gctgactaac    35400

ttctggtcct acagatatgt tggcacagca atagatctcc gtgggatctc aggcctgcgg    35460

acattcagag ttcttagagc attaaaaaca gtttctgtga tcccaggtga gcatttattc    35520

acagagcata tgttggtttt cacagcctaa ctcccttctc taattttcac aagaaccctg    35580

taaggttcca gggcaaagac tattgtcccc acttacaaga caaaggaact gaggcctgga    35640

gtataggaaa cataaaccca aggcctcttc actagtaaga gacagtgtga cctggaagcc    35700

tattgtccca actcctaggc cagtgctctt cccacatacc acatggcctc acaatcaata    35760

cgtaacagga ggggcatgtc ttcactttct gttctggttg tgggattcag gcaagacccc    35820

tcagttgaat ttttatttat accttaaact aaaggattaa acttggaaat ggggaggaag    35880

ggagaaagca gtcccagtat cttcactgtt tccgtaggtc taaaatcctg tctttagaca    35940

cccagaggaa aaaagaatta ggcaattctt gattactgag aattcagaaa caaaagtagt    36000

ccatcaaagc tcattgtgtg gggcctctaa gatctccact gtcaccagta gcccagcgac    36060

tactcttcag cccccatgag gttgatggtg aggatgggga ggccagagac aaggcaaact    36120

ttctgaaatg ggacttgatg cttcccctct gtggcctgat aggttctctc ctctcacccc    36180

aagaattcgt tctcttatct gtaaacagaa acacccattc tagagtggaa gtcttttcta    36240

ccatttcttg tctggctctg cagggaaaga taggaaactc tctgccaatt cccactggac    36300

acacctcttg aagagagccc tggtcctgcc ccttcatatc tctctcactt actctcaact    36360

gggaagaccc tgagtcttat ttgcaagacc tggtctgtcc atactgtctc ttctgcctca    36420

tctctcacct ctcctcacat ctcaccatgc tctggaatcc acctacggtt ctgcaaatac    36480

tccacaccat tgctcacctc ccagccttct actgtgctgc cccttcttct gggatatcct    36540

tcctcctctc tttactcaac tcacactcat tcctcagggc tctgccaagg ttttacctcc    36600

tccctggttt tcccaccttc ctcacactcc acccacccca ttcccacctc tggaacttca    36660

gttaagggct gctcccctgt gtgcccatct gctcagtaat gctacagact ttcccctcaa    36720

ttgtcagaca acggcactcg acatgctgct gccttagcca tcactcagct cccagtccag    36780

ggactgacac atgtagtgct cagtggatta tttgctgacc aaaatgacta accaaaaata    36840

aatcctagat tgcttccctg gtcagagctc tttctgctac ctgcgaagct gctctcccaa    36900

agaagttgat tttacttacc agagcaacaa atcatccctc cttaaacaag caggtgtatc    36960

cttctttgct gccagctgtg cttggcacaa gttctattta tgccccagtg actgtctcag    37020

tgtttcttat agtctctttc tattgctaaa ctcacctctc tgtttctctg tgtctctttc    37080

tttttctttc tcttggtcta tttttgtttc actctatctc tcttgcatct ctctctctct    37140

ctctttctct ctctctctct ctctctctct ctcacacaca cacacacaca cacactcaca    37200

cacagtgagg ttcatgtgtc ccaagtctca agctgcctcc cagatgcatg cagaaagaca    37260

gatgccaaat tactggggtg aagttagtag cttcatgcct agcacagtgc ctggaaaaag    37320

taggtactca gcataaatta tttaaattga attgctagtg tcaggaattt tattagcctc    37380

aagatgataa aaaatgcatt gcctgggtct cagttgcatc gtctttataa tgagaatagc    37440

ccctgactct ctgcctgcct ctcagagtaa atgcaagctt cggatgagaa aggtcttgga    37500

actgccctgg agtgtgtaca tacttcactc ctgtatgtag agatgaagga ggatggctaa    37560

gatgaagaag tgtgctccgt gtgtgctacc tcatccatgt ggtcatacca ctgtcatctt    37620

cccgcaggcc tgaaggtcat tgtgggggcc ctgattcact cagtgaagaa actggctgat    37680

gtgaccatcc tcaccatctt ctgcctaagt gtttttgcct tggtggggct gcaactcttc    37740

aagggcaacc tcaaaaataa atgtgtcaag aatgacatgg ctgtcaatga gacaaccaac    37800

tactcatctc acagaaaacg tgagtggagt ctcttccata gggaccaagg tctggttgga    37860

cccttggtat catataggga caggggatat ggagcccctg tgtgtgtgta tagacatata    37920

ttttgactcc cctttcctgc caaaatggtt ctcttgagtt gtgttttact tttgggtatt    37980

ctatttcctg ttgctcagca tccctcttgc aaggaaatga gccataaatc tagaggcaag    38040

tcattctacc tctgctgggg gagattgaga gccgaagtca ctgcttagct cttctctttt    38100

cagatgtgac tttacaactt ccatgtggcc cagcatgccc actgagtaca tgtagccaaa    38160

ggagctcact ttggaagact tgggaatatt gcattcacca cacaaggctt gggttggagg    38220

gttcagaacc atctgtgagg ctttcttttc ttcctttctt cagcagatat ctacataaat    38280

aagcgaggca cttctgaccc cttactgtgt ggcaatggat ctgactcagg gtgagttccc    38340

aacttatgac aaagcacgag tgcccaacaa ttccttctcc atcttgtcct tggcatatta    38400

tgggcacaga tggggttgca ggtcctggga aagatgtata aataaataaa tcatggcctt    38460

tgccaaccca gagctcatgg ggagggaatg tatgagttag ctttcgctgt gtaacaaatg    38520

accccaaaat tttgtgaatt aaaacaacaa tgtatttaat tcatgattct gtgcatcagc    38580

attttggact gggatcagat gggcattggg tgacattgac taggctcatt catgcatatg    38640

cagacagcat attaacttgg agatggctgg tctaggacgt cctgtctctg ctcatgtggc    38700

ctctcacccc caaacaggtt agcctgggcc tgttctcatg gcagtgttcc cagaaaaaca    38760

gtggaagttt gcaaggcttc ttcaggccta ggcttagaac caacacaatg taccttttgt    38820

acattctgat acattcttga ctaaagcaag ttgcagtcca gtagagatcc aagagacaga    38880

gaaatagact tcatcactca atggaaagag ctgaaaagtc acattggaaa gggtgtggat    38940

acatagagac aagaattata gccattttaa taaataatct accccaggaa ggaaccaata    39000

cttatttgtg tcaaatgctc tacacttaat catcacagct aactccattc tatagccaca    39060

ttaccctcac aagtagagga aaaaacacat gtatcagact ttgcaatttc gaattcttac    39120

agaggccaga ttcataacaa caaatgagtg gagtgggcca ggagggaacc taggagctga    39180

gagttcatgc ctcctctaaa ggggacagcc ccactgctcg gtccagcttt tggttgccat    39240

gtggaaatgt gggttcactg tttccagctc ttccaacttt taaaatagag ataggaaatt    39300

tagattttta tataaaatct cccaaccgta aacattggct acctattcca aaaaatgtct    39360

acatattgtt gggccaaaca aaatatttct gtgggccaaa tccagcctat aagctgctag    39420

tttgcaattt ctcattcata gacataaaga tgctaccctg tggaaaacaa gttctttact    39480

agaggcttca taggctgggc aaacacagtg aggtggcggt gtgaggcaag agagaaagta    39540

gggaaggctt cctggaggtg gtgtttgagg tgagctttca agggcaggta ggatgtctcc    39600

aggctgggtg aatacgagat agtttcagcg aagaccattc caggtggcag aacagaatgt    39660

gagacaaagc taagggatga ggacccctca gctctgcctg ctgctttggc cactggagga    39720

aggcatgagc agaaagactt taggcaaaag atcaaaaagg cccatctcac ccacctccat    39780

ggctgagagc ttggaaaagc agagctcaca acacccccag tgcctgagag gctgacggct    39840

ccatgttgcc caggtcgacc tgtgtggagc ctgcatgagg ctccaccttc atcagctcac    39900

taggaaaact atctcagttg gagctgagga ctggaaacaa gcaggagcat ttggtcaaca    39960

tcaggttcct tggactgttc tttcacaaat gcacttggca tttggttctt tggctcatga    40020

gagggttgtt ctgacatcag ttttcatttg cctttgactt aaatgtaaac caagagcccc    40080

tcagcatcct tctgtctaga taatggcatt tctcaaggca atggctccag agcagctcaa    40140

gtcctttttg tggtaaagtt gttgggtcca tctacacacc tctacagctc agctccctga    40200

gaggccaggc ctgctattgg gcaggtgcca gccaggcagt gggggagtgg accaggctgg    40260

gatggcagag agaggccagc tcaggataac ggacagagtg aaccctgccg gggcatgccg    40320

tgaaagctaa acctgggtcc tctgtggggc tgcagagaag ccagagtcct gaggaaaggc    40380

ccacattggc caatggcact gtgggaggaa ggtcaggggt ctcaaggcag aaaatggata    40440

ccagaaaata gttgataatt ttcagtgttc ttccacatat attattccag tttatccttt    40500

cagcagcttc caaggttaaa aacaatagga attttccttt gcagtttata tacaatattt    40560

actatgcaga agtgcaagac actatacagt gatctcattt aatcctcaga gcagtgaact    40620

gtttatatgc agtggctatg gtggatttct acagaagaca tagaaacaag gctgccctca    40680

gagttaatta agaaacctac aggaaatggg ttgcctagcc ccttggaaga gcaaaccaag    40740

agcctatctt taaatgtggg tctacaaagc cagggaactt gcaatcttca atcgaagtgg    40800

agatagactt ggaactgatt agaattaagt tgtcagagct ctaatccatg gtatgggttg    40860

ttcacatgga tgtctgggat aaggagagcc ccagaggttg gagttcatgg agaaatcctg    40920

ggagtaaaag aattccatgt attcacaagg aatgcaggta aataaaacag gagaaaaaga    40980

aaaaaattta aaaaaataat tctggacttc aaacgaggca ttgctgtttc attgatcagg    41040

ccatctctgc tagggtggat gagagcactt tacgctccct gagctgacag atgcttcttg    41100

acatcgactc atcctcctat tatgagagag aggaaggagt tcagcattcc cacctcaata    41160

ctcaccaggc agtcattttt aatctggcct tccttcatag gccatcttca ggaggaggct    41220

aggctgactc aagtattggg ctacttgaca gttatatttc tccttttaat aaatatattg    41280

acacctgcgt agttttaggc aactgacttc tttctgaccc ccagattcct tatctgtaaa    41340

gaaagaacat tgagtgatta aattatagtg tttgtaaagc acttaaaggg agagagaaga    41400

acacagaaag tgctcagtaa gtggaaagtg ttatttccac tgttacatat aattaatcag    41460

tgaacttggc taatgtgaga cctcccttga tagacaactc tgcagatgat gccaacaggc    41520

tcaggtttta agtctgcgtt attgctactg actctcattt ccctggtatg aactggcaaa    41580

gagcttatag tatcgtgtct gggcagtcag ctgccttccc caggccactc ccctgtgtat    41640

gaaattctga cgtgaaagta ttagcgtccc cgttttatgg ataacagaaa ccaataccta    41700

aacagaccaa gtgtccaaga tcatcctgct aataagagga agactaggtc ttgaactctg    41760

atctctgaca taaaactctg tggttgtctc gcagccctgg gctaccttgt ctgcaataag    41820

caggggatga ccttctctgt tcttgctgca gccactgccc tgatggttat atctgcctta    41880

aaacttctga caacccggat tttaactaca ccagctttga ttcctttgct tgggctttcc    41940

tctcactgtt ccgcctcatg acacaggatt cctgggaacg cctctaccag caggtactga    42000

gctgcattcc cccacgcaga cttggttgga ggctggtggg tcagctgcat ggctgtgctt    42060

ttcctggagg aggctgactt aaattcaggg gtccatgtgc tatgggtaca ggtttctctt    42120

ctttcccttg aacctgcaga ccctgaggac ttctgggaaa atctatatga tcttttttgt    42180

gctcgtaatc ttcctgggat ctttctacct ggtcaacttg atcttggctg tagtcaccat    42240

ggcgtatgag gagcagaacc aggcaaccac tgatgaaatt gaagcaaagg agaagaagtt    42300

ccaggaggcc ctcgagatgc tccggaagga gcaggaggtt tgtgaggagt ggaagctttg    42360

tgaagaaggt tgcagactgt ccattcttgg atactgttct ggactagcca cttcaattag    42420

ggcaccgttt agggagctat aggaggaatc atcttgcctc agggaccata ttagatcagg    42480

ttttctcaaa gaagaagcta agtgaggatt cttgtgcaag tgacctattg agggagtgct    42540

ctcaggagaa agcgaatgaa gcaaaacaga atggggcaga gggtggaact aaacaaggag    42600

tgttctcagc tagagaccag cttcagcttg atcccatggg gaactctggg gcatgacctg    42660

taccacagtt agtcctacct tgaggcaagg gggccagctt ttttttttta ccctccccat    42720

acctatccca gaagcaggca gccaaaagag actttttttg tagaatgctg caagtatgag    42780

ccatcagctg ctgccatgca agcagctcgg gatagctgtg ctgacctggt gaaagggatc    42840

tgggtggggc accaacagag taccccatga atgagtgggg gtgacccgag gtgtctgttc    42900

ctgccatggc ctaatcccac caccaccctg gtcctaaccc ttcagcttct ctgtttcaga    42960

tctctcaccc ctggcacccc atgtctgggg gacacattca tgctaagtcc aagcaaatac    43020

tattggctac acctgctgtt ctctcttcgc aggtgctagc agcactaggg attgacacaa    43080

cctctctcca ctcccacaat ggatcacctt taacctccaa aaatgccagt gagagaaggc    43140

atagaataaa gccaagagtg tcagagggct ccacagaaga caacaaatca ccccgctctg    43200

atccttacaa ccagcgcagg atggtaagag gctcaggttt gtgctctaaa gattacccac    43260

cattgcagct gccgtagaca atgagttgga gtgggaagag gtgtgtggca gagaaagagc    43320

tggaggcata gagcctaaaa ggatccagac acccctccaa aatggtgtct taaactagga    43380

aagtgtaatt atagatgggg aaaaggggtg aattataagg acaccttagg gaagtggatc    43440

aacaagattg ggattgtgga ctgtggaaaa aggaaagggg agtccaattt gactcccagg    43500

tttcaggatt gggcaatcaa atgggtggtg attccaagat gaggacactg gaggaagaac    43560

cccggtttgt aggaaaggtg ggaagcccat actgaacatg ccaatcttaa ggtgtctgcg    43620

gacatcaaag gtcagcttcc ttctgaggct ctggtctgca gttctagagt gcaaggttcc    43680

ctgtccgtgg tgctgagatc cttcatgcac cttttttttt tctgatgcgt cgaggtggtt    43740

tttatttttt tacttagttt tttttaattg acacttcaca attttatata attattgggt    43800

ataatttctg acctccttcc taaggtcctg caattcaagc tgtcacctgt tgttatcaga    43860

aaagtttcca gcacccatct ctgtgacaca atccagcctg ggaatggctt cagcacctca    43920

cctcagaccc tgtagcaatt cttttccccc cataataact ttctgcctcc cactctaaaa    43980

tttgcactgc aactttcctc gccacgcttc ctcccaccac cttcctgccc cttgaaagtc    44040

cttttacccc aaatatgccc tttctatagg tctgacagat aatatctgct gtgtgggagg    44100

gtggctccac actaacagtg tggaaaaggg gatcaacatg gctatttttt tatgctttat    44160

acctctcact tccctctcaa tctcttttcc tgtgctaagc cgaaggatat tttacttttt    44220

tgcaatacca tctctccaac cctcagattt atgtgtgcat atacaaacac agacacactt    44280

gcatgcacac tgacctcatg acacatccac acttcagcat ttatctgcat ctgtgccctc    44340

ctctttcttg ctttgcccct tttgagcagc acctggcata catggggcac agttcagaca    44400

atcacagaac aggatgaatc acagcttcca tggaaatgtc aatgacactg aattgggctt    44460

taatttcccc cattctgtca gccccacaca gattagcact tggatgtcca ataattggta    44520

tgtgtgcttg tctctccagt gatgcttact ttcaaaggga aaaaagagga gctgtaactt    44580

gttcattcaa caatactagg tgcttggtat aaagagatga ctagaacatg ttcttttccc    44640

taaggatttc catttgggtg gaggaggcag atataaacac agctatgtgt taaatagtgt    44700

attagagaca catacatggt gttttgagaa tcagggaaga aacatccact cttatggggc    44760

tggataggta tcagaaaagg cttcctggag gaaggcataa ttgggatcaa caataaatag    44820

catgtagggg ttcttctagt aattgaagac ttgagagagt ttggggagga gtattttcct    44880

ggcagaaaga acaacatgta tgtgcaaaga cagggaggca ccatttaagt acttctttaa    44940

tgctaattga tttattggag cccactcagg aaggcatcct ctccctcttt tcccaggtac    45000

attcatgtgg taaatagacc taatgcagtt tttatctaaa gccattttat aaccaataga    45060

aattaaatag aggaatatat agaagagacc caggagggtt tttgtggaaa atcacagacc    45120

agttggtctc gttagaggat gaattttaaa gcaattctaa tgcttatact cagaagacat    45180

tgcccaccat ttgtcaaaac cttaattcta aaataactcg tggccaagga gacactgctg    45240

tcaaatatgc aaccaaaatt ttcttctcag tttcttcatt ggtttgcttg gtgctcaagt    45300

gcaaataatg tagtattccc ttccttaata tggatgtgtc aatttttctc atttgcttca    45360

aaaattggaa ggatttttgc attttatgag ttctatagtc cttgggcatg tattacaggc    45420

agagagtact ctatttataa tactgagctt ttaataatgg ttgctaaaca ggatcaggct    45480

tcaaattatc aagagaggaa acttcagttc tgtgagataa ggggattagt aaggagaacc    45540

ccaattggca agattctcca ctttagtagc ttagtaataa aaaggagtta aggaaggtga    45600

gtggaataaa tcggtatgat cagagtttgg tatgaagtca atgtttagat tttgtacata    45660

ctatagacca cctgaggaca caaatgatgg tttattatgg tcaagtttca ctatggtcat    45720

gggaactacc taacccagca cactaattct ctgagggctc tgggtttatg aattagctct    45780

tttctctggc aactttaagc cacacagttc cctcaatgga agattttgat gggaaatgtt    45840

tattgatttg gaggaatgac attattcttc caggaaatta ggctgcaacc cttccttcag    45900

tctctccatt gttgactgtt caagcctcga gggatcctag aaactcattg cactgtacag    45960

ctcttgtctc ctcctttgca acacaaactc tcacattcat acagatggga tctaatgaat    46020

tgtactacct aattttcaga caatgaagtg cacttattca ttcaacaacc acttaccaag    46080

tatgttccag tactggtgtg catagtagcc tccttaggtc acaactttgc atgtggaaaa    46140

gtgaacttag gacagctttg tctagccctg tggccaaagg ttggcaatca actgaactat    46200

ccaggtgaca aggtttcctc tgacatgttc ctgaccatga taacctattt gctgagcatc    46260

agcacgctgt aatctctcct ctctcctggt ctttcccgga gtctatctag agtctccttt    46320

tttctttttc cccaccatgc atacctagaa taccccttag atttgtgcct ttacttagtg    46380

actgaaaggt cataaagaca ggggcaggga aatgggagta ggtagaggga agtgttgggc    46440

tctagatttc ccagaggacc agtttccagc cttcttgctc ctttggggca atgcccagtc    46500

ttttctaggc ctcgcctctg gaaaacgccg ggctagtcat ggcagtgtgt tccatttccg    46560

gtcccctggc cgagatatct cactccctga gggagtcaca gatgatggag tctttcctgg    46620

agaccacgaa agccatcggg gctctctgct gctgggtggg ggtgctggcc agcaaggccc    46680

cctccctaga agccctcttc ctcaacccag caaccctgac tccaggcatg gagaagatga    46740

acaccaaccg ccgcccacta gtgagcttgc ccctggagct gtcgatgtct cggtgagttt    46800

gtgaatgctt cagactccct caggctgtct tccacctaga agccttgagc caagaagcct    46860

gagtatcacc aatggaaggg atctttagcc atcatcctgt ccaatgcctc cccattctac    46920

tcctttttta cagacataga agatgagacc cagagagaga gagagattga gttggcctga    46980

ggtcaaacag gtttcctggt ttattctgca gtagtgatgc aaattatatt ccatttgacc    47040

ccatatttct tatcagtgct tctctgtccc cactcaacat cactgcctca gtgataggcc    47100

tgctttcttg ttggacaggt atgagaaaaa ctgaaggacc cttctcttcc tgcttatggc    47160

tctatgcaaa ctcttctagg ctgggcaaat ggcacccaga gaaattcagg aagtttctta    47220

ggacagatct gaatagaagc acagtattcc ttgctttact cacagaagaa ataatttgcc    47280

aaaatgagca aattaggcaa cagtgactaa ctggccagca ctctttaata gaataatcgc    47340

agagtgtaat ggcaagtcag ggattcctca ttggattggg agctgtgagt taatgtgagc    47400

tctcccctcc agtttcagca atgatgtttc tagtgttttt catttgccct ctctggctag    47460

ccagggatac agcgcaattg cagacagaat tgtaaagaga ccaataaatg gttccactga    47520

tacagataag tcttagagtt gccttagctc agtctctgac tcaatgtcat gtgattcagg    47580

gtcccagcaa gaaacagatg gaccactccg atgggctaat agagagagtt tagtaaagta    47640

tttacagagg tgtgggctgg gcttagggaa tgaataaggg acagtgaggc acctagaaac    47700

tagtaacagg gggaagctgt tacatgccta ggctgaaggg atgaaggaaa ggaccagaat    47760

tagactacag cagcagctgc cctcatgtgt cagagaggct gcctggcaga acttgtgatc    47820

ttagtagagg atcacagctc tgctactcag ccatagcaca ggagagaaga agccagggga    47880

aaatacctga cttgtctctc cttctatcct tgaatgtcct gcctatgtct cccattaacc    47940

aaacctggcc agaaccagag ggtaaggata acacattttg tacaggtctc cctccccagg    48000

aacagagaca gtggagaagg tagagagtag gtctccaggg caaatggaat caccaaaaca    48060

gagccttaaa gtcaaaggca tcctgcaggg ctcgctggga gtgcattagc actctagaaa    48120

atgcctcact gaaggcattt atgcctctct tgtgatgggc ccccaccctc ctttctctgt    48180

tcctgagatt atcatgtgtc tagatattct gaccttgatt cattctagtt aaattaccag    48240

gctagtgaaa gattgactct ttaggccctt ctgtttagta tggacctata ttttagtccc    48300

aactgtgcca gttaccacct gagtcacatt tagcaagtcc tttaaattat ccaagcctcc    48360

ttatctcccc ttgtaaaaag gtttctaaat agctggaggg ttaaatgaaa taacaaagtg    48420

cctacatttt tatacatgtc tgacagataa caataaatag tgactactag tatcatttgc    48480

ttagtcctca tggttggaag ctttataaac tttctttatg tttattaact gtttatactt    48540

acagtattca gcaataacat gctgtacaga tttgtagcct aggagcaata ggccacacta    48600

tttagcctag atgtatagaa ggctatagca tttgtttgtg taaatacaat gtaggatatt    48660

cacagaatga tgaaatcacc taatgatgta tttgtcagaa catatctcta tctgtaagtg    48720

acatatgact atatatgaga ttggccaata agaggctgaa tgatccaact ttgccatgaa    48780

gatgtcaggt taaaggagcg tcctgactct gtttgtgtct caacaggcat tcgatgcagg    48840

acaaaagaag actttcttgt cagcagaata cttagatgaa cctttccggg cccaaagggc    48900

aatgagtgtt gtcagtatca taacctccgt ccttgagggt aagtgctgct cactgcattg    48960

ttcatccact gtgtcatgat gaattcccat gtgagcagca gaagcaatgt ctctaactcg    49020

tgtcaaagcg tccatctctg tgtactggaa ttcctaatac tcctcattct tatgtcttag    49080

gccccaccat cttttatcaa tgtggttttt tagatgcata atttttcaaa aacaaaataa    49140

tttgatgaat aaaatatcct agctcatctc ttgttcaaat tagcatctgc tttgcatgca    49200

tcacaaaact agatttttaa aagtgatctg gcaggcatca gagaatttca ggccagctct    49260

ccggtgtaca agaaatttaa ccatccttaa ttttccaaca tggcaaaatt atccttttca    49320

tggtttcata attatatttt tcatggttgt aacttacaca gttgtaattt aatttcttgt    49380

tcaagcccac attatgctga atattggtag acaatttaag tccattaatc agtcaattta    49440

actaagtcct tgttaattta gaattctacc aatcaagtgg gaatccactc agtctcccca    49500

gcaatgtatc taagttccaa gccaaagggt agaggaagag agtggcaatg gtcatggcca    49560

cctatccaca cactttgcca tagagcgtga ttgcatccct ctaaccttga gcaggaggtc    49620

tgttctaatc cagccttttt ttgccttagg gtatggagaa tgcaaccttc atcatttcca    49680

gttatcttac tcccctagac aaattaaact gacctaggct ggaggagttg taagggagct    49740

tgagtgctgg tgtgcccctg agaaggagtc ctgtgtgttt tcctcccagc cctaggctga    49800

atcctaattt gaggggaaga agtggtgagc aatagaaacc aaaaaaatgt ttgagggatt    49860

tcaaaacaga gccaatgtgt gccctacttt ctaggtaaag ccagaggtgg caagccttag    49920

agagagattc acatgcacag aaactgtaga gtagaactag ccagtaattt accagatatg    49980

cagagatgta tctgttttgc tcacagctgg atctccatta cctagaagag cagtgcatta    50040

acaaaggtga tatctggggg gtgatgctac tttatagtgg tgtaaactga taaaaaggaa    50100

gaaaataagg aatagtcagg tatcttgggg taggatagac ttccgctcaa ggaagatact    50160

gtgagagtag agtaagaaag gcaggagaaa caaagacgtt tttaagaaaa tctggggaaa    50220

ggcaacctta gcttaggtca accttaggtt agagaaggcc tgaagcagcc tcagagagag    50280

ccctgtggct ccagaatggc agagaggagc tgggtgatga cttagccccc agtgaaggct    50340

atggaaaaag atgagtgaga cccatagagg gaaactagag agagaagagc catcttcatg    50400

gactctccca ccagggacca gatgggagct acaactcagg caaaatacgc ttagcaatga    50460

caaaggacca gctcaactct cctccaggtt tgagccctac aaaactcaga cacagactca    50520

gatattgaaa tagtacccaa cattgactta acaagagaca gttcccatgg tgaggacttg    50580

aagcataaat tgaattcaac taagttacat ttcttgcata cctgagtttg tgctttgaga    50640

aatgtgtact catttctcaa caacaacgtg tacagactct cttctattat tttttctcat    50700

tgataattat ttaatatcac tgttcattgt aatagagtct gtacttctaa catttttcat    50760

ggcatagaat ttgaccaagc tgctattccc acaatttctt tcttggccag ataggtttct    50820

tggtttttgt ttgtttgttt tggtttttgt tttgctatta gtcatcaaac agcaaacatt    50880

gaatacaaac agtttgtttt tttcatttat tctcgaaaac tgttaagctt cctccttctc    50940

tcttctttca tttattctct tatcaacaag catttgttga gcccctgttg tgtgtgtggc    51000

attgcttcag gtgctgggat tcagtggtga actgatataa gcttgcgctc atggaatcta    51060

catcctagca gggaagggga catgaaagat gaatagatat tcagatataa gaagtaggag    51120

aaaaaataaa gtaggaaagg agatggaaaa ttctctccaa gaagaacaga aatttgaatt    51180

aaataaagga atcagctatg taagaagctg aggagaaagt tcgcagacac aaatagcaag    51240

tacaatgcat tctgcaagaa tgagatagca acaagcaaaa tgcatgtccc aaacacatcc    51300

cagtgtaggt aagacaaaag aaggtcatgg gatgaatgag aggcaacaga gggtagtagt    51360

tagaacactg ctctggaacc cggctgcctg ggtttgcatc ctagctcttc cacttatggt    51420

acacagtgtg accttggagc ttcagtaact tttctgtgcc tcagattttt agcctgtaaa    51480

gtagtgagaa tatacttatc ttgtagagtt ttgtgaggat taaatgagtc aggtcaagca    51540

aaatgcttag aaccacgact ggcatgtagt aaatactcat cacatttggc tattatgatt    51600

tactaggttg taaaatctat gagggcggag atgtgtctgt tttgctcaca gcctgacctc    51660

cattacccag aagacaagtg catgcacaaa ggtgatattt gggtggttgg cggcgggagt    51720

gatgctaatt tataacagtg tgaactgata aaaaggaaga aaataagtaa taggcaaata    51780

tgttggggta gggtagactt cccctcaagg aagatgctgt gacagtagag taagaaaggc    51840

cagagaaaca atgatgtttt aaagaaaatc tgaggagagg aaaccttagg ttaaataaaa    51900

gaggtcaaag ttttctgagc atagggcaca tcatcttctc tggttggatg ttatattcat    51960

tacacacatg agacacctga aggatgcttc atgctgccag agtcgtaata ggatttataa    52020

aggccacctc tttaagaggg attatgctta agaaagtttg gcccaaacca acaggagttt    52080

gacaattcac tgaactcaaa gcatgtgaac cttctatgct tggcatgcaa gctgagattt    52140

cactgttgtc caagccagaa ttccagaagc tgggtcacag cagtgagctt actggagtgg    52200

tgagtgcctt aaagaggaag tgcaggatac taagtgaaat atggtaagat ttgcctggag    52260

ccagggaatt atcccaggct gaaaggactg caaagcagaa gagagaataa catttgaagg    52320

aatgaaaaag cctaatgtag ctgtaaccta gagaaccagg agaactgaaa ataaggctag    52380

agggatgagt tggggccaga tcccaagaaa ctcctagact gcattaagga tatgggactt    52440

catgctaaga ggagtgaggt gccattaaag gattggaggc agggaagtta catttgcatt    52500

ttataaaagt tactctggat acttgtagat ataagagggg aagtatgttg tcagggaaac    52560

cagttaggag gaagccaagt acaagatggc agtgcttgaa ctctggggta gtgacagtgg    52620

ggctgatggg aaatggaagg atatgagagc tatctaaggg gcataagatt caggacttga    52680

tgatgcatat ggttctggta taagtgcctt aagatatgct gatacaataa ctcataaagg    52740

gagcatttta ggggaagaag ggggctttaa tggggaaaga tgaaagaaga ttatgagttg    52800

agtctgggat atattgggtt tcaggtgccc ttggagcatc taggtagggg tgtccagtag    52860

gaagttgact ttaggatata ggggtctaga acttagatga caaagatggc atatatatat    52920

atatatatat atatatatat atatatacac atacacacac atatatatat gtatatatat    52980

atatttgaaa gcagtttgaa tgtaagtggt aattttgaaa agatgcaact ggatgagtta    53040

acacagaagg gttgaagtaa gaagagaaga aggcctcaga cacagttcta acaaactaaa    53100

tgtttaatag ttaagcagaa gagatggacc cagcagagga gactgaaaag gaaggtacag    53160

aaataggaaa agatctagaa gaatacaatg cagagccaag agtaaaaatt tcttcagaaa    53220

gaatagaaag gccaacagag gcaatgctgt ggaaaggtca ggtaaaatga aacatgaaaa    53280

ggtccagggg ctttagtcac atggatgtct ttggtgatct aagcaaaaga ggattaatgg    53340

agtaaaaggg taggcagagg tcatattgaa ggggcttaaa gagcgggtga gaggtgaaga    53400

aatggagata tggtgtacag acaatttttt caagaagttt gcctgtgagg aaaaggagat    53460

agtaagatgg cactagggag tagggagaat tgaaagaaga ctttttggtt tttgtgtttg    53520

ggggagtttt tgtttgtttg tttgttttga gcatatttgc atgctaatgg gaaggatctg    53580

ggagaataag agagactgaa gattaaggga agaaagggta tattcaacag actcctgcag    53640

tggcaggaga gaatgcacag tggagacact ggtgttaaca ggagcagggg gacctcttta    53700

agcgtaacag gatgaaggga ggaaagttct ctctgttatc aattttatat aggagatcct    53760

tttgaggtgg ggccatggtc atgttttaag ctggcaagta gatactttta gtctctgtgt    53820

ctctgcaatc aatcaagttc aacaatgtca aggctgttta caaagatgcc tctcttttcc    53880

catcatgcct cacaggtggc tgcttcctgc caaaatggca catctaaagt gtcctcattc    53940

atgactactt cctgtgcttc tttttagtgc caaaataggt ccagggaagt tcttgctttt    54000

gttccaaaca gggattgttg attttggtcc caggatgtgc caacttcttt agagaactat    54060

gctttgccag tttggacatc tgtagtttct aaaatccagt cagtgattaa aacagcatga    54120

cagtgaaaat aaatagtctg atctgtggaa gagaaatgga catgtgtata tgaaaacaca    54180

tgaacataaa tggtaataac atgacaaaaa tgacatttca aatcttggga aaatgaaaaa    54240

ttattcaata agtaatgttg atataaataa tcagagacag gaaaaaataa accacatcaa    54300

tatcttactc tttacccaaa ataaatttca aatgcaccaa agttttaagt gaaaaaagtg    54360

aaactacaaa agaaagaaaa aaacatggag aaggtatttt ccaagccttg tagtgagaaa    54420

agcttcatat gtaaggcatg tatgcatatg tggctaacct gcataatgtg cacatttacc    54480

ctaaaactta aagtataatt taaaaaaaga aaaaaattta aaataaaaaa atgaagaaaa    54540

ttgaaaaaaa aagaaaacaa ataaaaatac tactgataaa tcttgactac atacacattt    54600

ttaaattatc aggaaaaaac actgttagca aaatttgggg gcacacagtt atttctctaa    54660

actgattttt caagtgcata tagtaaaaaa aaccctaaac actgcaagtg tgtatgcaat    54720

gacaactatg tctccttccc actatagacc cttcctgctc cccagactcc tggtgcaccc    54780

ccctcccact ccagtttatc ttatattctt caagcaatgt tctatgcata tataagcaca    54840

tgcatgcaca tacacacact acacatacat atttttctac atcaccacaa ataaatctgc    54900

ctcattcttt ttcacaatgt attatgcttt atcagttgtt gttttccatt attattataa    54960

acaatggaca tcatctttct ttgcccacat aggctgatat ctgttcaaga tgcatgtctt    55020

gccgaggaat ttatagataa acctaaagct aagaaattgc cctccatcga ggtgaacaca    55080

gttacacatc cacatggaga tttaacggag gcaggtagag agataagcct agtgttcagg    55140

aagggatcag aaattggaca cataatttgg tgggaattgg catagagatg gttttttagg    55200

gctatgagat tcaaaaacac agagaagcta aggtgagaat gcttgagtta ttcaacattt    55260

acaagcagga aaggaaaagg gagacaaaaa cagaaagtga aaagaagtgg agaaatatgg    55320

gagaaaaagc aagagatgat gcagtcccca gagccaaatg aacactggtt tcaaagagaa    55380

caatataaat tctgtcaaat gttataaggg taagatgaga actggaaatc aattatttga    55440

atttggaagc agttaaagtc agattccagg ggctgcagag aaaaaaagag gtaaggagct    55500

gtagaaggtt aagtgtagaa aactcttgca aggaatttta ctgtcaaaga agcagtaatg    55560

aaagagagca tggggtccag agagactttt tcaaagccgc gagataatta aagcatgttt    55620

acctgctcat ggcaatggtc tggaagggag acaggtctgg atgatgcagg ccttgaatag    55680

gtgggagagg aaagagcccg gcacaagtgg gaggggtaga gccacccacg cactgtgtgg    55740

ggcacgaaga cagaatacca ggtggacttg cagatatgcc agagatttag tggtaggaag    55800

aaggggaagt tcttttgtga actagtctat attctgagtg aaataaaagg gagctcatca    55860

acagagagta agtagaaaga agagccggag gttagacggg ggaagaggaa gtgagaaaca    55920

gtcatctgga agaatgaagg aatggaatat aatatagaaa cacagccaga tttctgggca    55980

gggcaaggct ggggctcaca gatctctagg agggttggta agcatagttg tgtatttttt    56040

ccagccaggt ccagctggtt gggtgcaagt acagagtagt ctacaaattg ggtctattca    56100

cagttcaggt tttgccaggc aagtacaatg aaggaggaga ggggcaaagg aattgagggt    56160

gcctacaagg gagtagttag agagatggat gtgaaatcta agctgggcaa attgagaagt    56220

aaggacatga tataggtgat gggcagtaaa aatatgtaat gtcagcagtt taaaggactg    56280

gatggggcag atattaattg gagttgcagg actaaaggag ttcaaaatat aggaaatgaa    56340

taccagagac agagagaggg ctgaagtcaa aatgttggag gtggtactta ttattaacaa    56400

caaggtctag aggatgaccg cagaattggg gtccaaggtg acacatggct gacagctgtc    56460

attgaccaca ctataatgca gaactcgagg agtctgaaca gaagtgccca ccctgcttga    56520

ccagcttgtc tcagaagtat ctgatctggg attgctgccc catgtgggtg aagctcaaga    56580

caattctctt tgggcttgtg acggatccct ttgcagagct caccatcacc ttgtgcatcg    56640

tggtgaacac catcttcatg gccatggagc accatggcat gagccctacc ttcgaagcca    56700

tgctccagat aggcaacatc gtgagtgctc tggctggtac tgccctcact ggcgtggtcg    56760

gggcggggtg gggatgatgg cagggtgcag ttcgggtggg gtggggcatg cccttattgg    56820

ttagtgtgtt gagccagtta gctgagagca gagcagcagt gcaggagaca tgtggacact    56880

gggttcagga ggtcaagtgt gggaggaccc aggctgagct ggtgggaatg gctttgggat    56940

gaacaagcac aggaaagtga accaggagag cctggagcca gaggcagcta gttgcccttt    57000

acaaaacata ggacaaccac ttgaattttc tggatctcag ttgcctctac cttgaaatga    57060

ggataaatgt cactttttta tctaaagaca atctttggac ttgtctgttt ccttccaatg    57120

taattacttt tatgaccaca attaacagta gccacgattt tcaatgttgt cacttaagga    57180

gaaaaagagt tggggaggga aggggaagac agtggaaggg aggaaacatg gaaacaaggt    57240

tgctgttgta acaaaagcat caggaagtcg gaacttttct ttggcatcta gtttagacat    57300

catgctgctt taaattttcc tccatcactt gttagtatta tttactctta acaagataca    57360

atccatactg gatttcacta tatactggat aaagtatctg actcagaggg acaacaactg    57420

ctccaacctt gccccaccca caggaatagt aataatactc agatgcttct catggattat    57480

ctcattttat tttcacaaca accctacatg gtaggcactc ttgttattcc ctttcccaga    57540

tggaaaaatg gagatgcaaa aggttaaata atcttcccaa gatcatagag ttgagtttag    57600

tggccacatc agaatttgaa cccagacaga ccggctgcca agcccgcttt tcttaacccc    57660

tgaattaagc cacctcacaa gacttgcgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg    57720

ttcaaacaca cgcacacatg ataggcagaa gctagaaagg gtcagcatcc tgccttcatg    57780

tccgcagcag ggtccaccaa gctggaggtg acctactgga ttcaccagaa ctgtctggct    57840

ttggggtcca gcttcttata ggctgcagac ttaggtggag ggggaaggcc cagaggaaat    57900

gtgactactt gtccctagaa accactccct ccgccataat ccagggctgt gaaaggggca    57960

gcagtaggtt ctggaacatg gtggaatcag catgcctcat gttttggcag cacctaggct    58020

gaggtcacat cctaaagttg atatgaaaag gaaaaatgga aagagaagag aatgcttatt    58080

cccaagaagt cagcctaaga ccacagaggg ccttatggaa tagacatttg agcccacacc    58140

ctcattctac agttagaaaa gtggaagcaa gagagagaaa aggcctttcc cacagtgtca    58200

gaggaaagtg ccactttttt aaagcaagaa agtcatgtgc ttggtgcctg caatgagtca    58260

ggtgctttat gaatgttatt tcagtgtcac aacaacatta tgaggttaac atcaccctca    58320

catgacaaaa gagagcacta agactcagag aggttaaata tcctgcccaa aattgtatag    58380

ctggtgaggg tggatccagg gtggacccag gtctctggaa gacacaagac ctcaacccta    58440

ccccccacca caccacactg acttgcctac aagggacact ccatagatac tctttgaatc    58500

agtcttgtgg catgagaaag tcacttaaac tctcagcctg ttttcttctc cataagaagg    58560

atgcattgtc tgtttctcag gctggtgagg ggctcagata aaaagatatg aaggaaaagc    58620

acctgaccct ggtcgttgct ttcctccttc tctgtctccc ttccctgctg gttgttgtgt    58680

tacccgagcc tggttctgac ctctctcagt gtcagaattc tgtcctattt aagacaatta    58740

gagacacaca gagcctaaaa gaatcttaga ggcaatgaat cattgttctt actagtcact    58800

gttacttatg aatgaattac tgtctgccag gccctttgtt aagaactgca catgcattgg    58860

ctcattttat gcccattata cagatgagga aattgaggta caggaaggat gcattatttg    58920

tccaagctta cataagctag gaaatgtctg ggctgggatt ttaatccagg tctgtgatgt    58980

cccacaaccc acacgtttta actactgaac cagactgact cttcactgac aaaatgatat    59040

tataataatg atcttaaaga ctatccgctt attccactcc caccaccatt cacgtggaaa    59100

aactgcagca tgcacagccc ctgagaatgg tgcagaaatg tctccattct gtcacgttga    59160

ctgttaccct ggccaatcct caggagccca cagataacat agcaactgaa caaaacaaaa    59220

ggattttcta ttttgtaaat aagacatttt cttgctgcca tttttatcat tgcctccgac    59280

cccacagatc ccactgtgat gaaagcttgt ttccactcct aggtctttac catatttttt    59340

actgctgaaa tggtcttcaa aatcattgcc ttcgacccat actattattt ccagaagaag    59400

tggaatatct ttgactgcat catcgtcact gtgagtctgc tagagctggg cgtggccaag    59460

aagggaagcc tgtctgtgct gcggagcttc cgcttggtaa tgtttttctc ttgatggctt    59520

ggggaaactc ccacccagat tcagggaaga cactgtgctc tggggactgc accagccagc    59580

tcccccttcc tctcctgtcc ttgtgggagg gagcagggtc tgactcctgg gcgactggag    59640

acttgggtct gtggccccag cttttcgctg actcagagtg gggacatgcc ttctcctttc    59700

tgggccttgg ctcccttatc tgcaccaaga ggggacttcc aagcactgtc ctcgtctctt    59760

atcaaataac aataacagca ataatcacag cagctaatac ttactgagca cttacaatgt    59820

gtcaggcata gcactggaca cttgaaaaaa cgcacctcat tttatgctca caacaaccct    59880

gagagatagt cgtttttaag atcctcaggg gtgggtgagg aaaaagaatg gttccatgat    59940

gacccgaaag tctcccatct gccaagcaag cgaataagcc acagacctgg atctcaaatc    60000

caggttgtct gactccagag ccccagctcc ttccagcctc aaggaagtca ttctctgatt    60060

cccttgtgcc cgaaatcaca gccccaatgt ctcaagcacc ttcaacctgc ctattagtct    60120

cactcacatg caatgatggc tcttctctaa actcagctcc aggacgccct ctacaggaga    60180

agtgccacag gccacccact tttatcagag ccacaggttt gtcagccaaa cctgtcagat    60240

tcccaggagt gtcgggtcac taggtctcca ggccatctgg aggaagcttg gcatctcact    60300

gactcttggg aataggaaag aggcctgaag aaatgtcacg gcttgttagc gcaggccgcc    60360

tgctctcagg aatctctcag tattaactgg gagccctgca tctagacttg aagagaggtg    60420

acaaaacaaa ggggagtatc caacaatctt cccaaggtcc tgacaagtgt tggcatccag    60480

aggttgaagg gggtgcatgg ttcaggaggc aacgagactc taggacagat ctgcttggga    60540

ccctatcaca ggggccagtg agacagtgct gagcccctga acttggcgta cctggattag    60600

gggtggcaaa ctcaaatgcc catgtgcagt gacatagagc cagccatgga agagatgtgg    60660

gcactggata tttgcctcag gtagacaggc aaagatgact ccatttcacc taggcagacc    60720

caaagcagtg cacaactcct gggagggatg tttacataga aatcaatgtg accatctcag    60780

gccaggtgca gtggctcaca cctgtaatcc tagtactttg ggaggccgag gcaggcagat    60840

cgcttgagcc caggagttca agggcaacat ggtgaaaccc cgtctctaca aaaaatgaaa    60900

aaattagcca ggcatggtgg tgcacatctg ttatcctagc tactcagaag actgaggtgg    60960

gaggatcacc tgagaccagg gaggtggagg ctgcagtgca ccatgatcgt gccactgcac    61020

tccagcctgg gagacagagt aagaacctgt ctcaaaaaag aaaggagaca cagagagaga    61080

ggaataaaga tagaaaaagc gagagaaaga cagatgaaag aaagagagag agcaagaggg    61140

agagagaaag aaaaagagaa agaaagaaag aagaaagaga aagaaagaaa gaaagaaaga    61200

aagaaagaaa gaggaaggga gggagggagg gagagagaga gggagggagg gagggagaga    61260

gagagggagg gagggaggga aggacgagct atggcctgtc cattattgtc agagttacta    61320

attttccaaa aaagtcagaa atccagattt ttgtgcaaat gtctttaata ttggctacta    61380

atccagtttt taaaaacact ctaaagacca aataaagcat gtcctgagac acagctgtgc    61440

catgaaacgc tggttgatgg catctgccta agctgatggt actgtcacca tcccagggag    61500

gagaagggta gagtaggcct ggtaggactc tttatccata acttgaaaat cttacaaggt    61560

cagaattaaa tcacattttt agaaggacag atttctctag gtatctagaa attgatgtca    61620

agatgtaggc ccctaagcta atggtcaata taaggtacct atgcacaatc gtcaagagag    61680

caggagatat cacaccccca taccctggca ggcccacagt tagttttcta ataaaatacg    61740

aggctgggcg cggtggctca cgcctgtaat cccagcactt tgggaggccg aggcaggcgg    61800

atcacaaggt caggagatcg agaccatctt ggctaacacg gtgaaacccc gtctctacta    61860

aaaatacaaa aaattagccg ggcacggtgg cgggcgcctg tagtcccagc tactcgggag    61920

gctgaggcag gagaatggcg tgaacctggg aggcggagct tacagtgagc cgagattgcg    61980

ccactgcaat ccggcctggg ctaaacagcg ggactccgtc tcaaaaaaaa aaaaaaaaaa    62040

aaaaaaacga acatttctgc tacacttggg gaagcagaag cttagtgttt taaggtctat    62100

gtgctacttt tgttctgatc ccacagtcta aagtcccaaa caaccaaaaa taggcaagtt    62160

tacttcacag tctgccccta caggattctg caggggaatg ctaccctgtc cccacctcgc    62220

tgatttaaca tgctgatcag tgctcaattc cctaaccaca cccaccaact acacactttc    62280

ttgggatcta ttccacttcc ctcatgacct agcttagatt tcacagccca ccaatattat    62340

tatgcccttg aaaacaaact caatcacctt ttccctctgc ctctttgcgt ttttgtgttt    62400

gccaaaacct caccggagag tctaagtcaa atatttctct ccaccttgtc tgcacctgag    62460

ctgtgagaaa tgctggagaa aaatcaccgc cagctggtca gtttcctggt tttaattaat    62520

agactttatt ttcaggacag ttttcagttt tcagaaaact ggagcagatt gaacagaaag    62580

ctttcatata ccatcaatcc cacaacacac acacacacac acacacacac acacacacac    62640

acacacacag agtttcccta ttaccaacat cttatgttag tacctacatt tgttacaaat    62700

aacttcactg gtttcccatt gctctgagaa taaaatccag actcctcatg atggtgtaca    62760

aagttctgca taatcaggac ctgccagttc accagtctcc gtcttgccca ctttgctcca    62820

gccaaaaagg cctactctct cttcttcaca cataacagag aacttcttgg ctttgggcct    62880

ttgaagtttt tttcgctgtg cctggaatac ttttccttta gtcttcactt agctcactta    62940

ttctcaaact ctgtgttcaa tgcacttgtc acctccttag aggggacctc cccaaccaca    63000

ctatctaaag ttggattcct tcatcaaatt aacctggcat ttacaattgt cctgctatcc    63060

catgaggcaa aaaccagagt ttcttgtcta ccgttttatc ccaagggcct agcacaaggc    63120

ccagcacata cataggaact caataaacac ctgttgattg attgaaggaa ggaaagaaag    63180

agaggaaggt ggagggaaaa aggaagaaat aaaaagtctg tcttccttct ctcccaaaat    63240

agcattgctt ctcctcccgt cacttaaagc cttgctccat ttgctctgtt agtccattgg    63300

tctatcctgg caccaatatc agtcttaatt atggcagctt taaatatatc tgtgtctgta    63360

aatcaagtaa tccacctaat ttacttcaag aatatcttgg cctgcacact ttcatattca    63420

ctttagaatt atcttgccaa gttacatacc cacatacaca caaaactgct attgtttttc    63480

ccattaggga ctgctgtaat tgataggtca atttgggaag acttataatc tttacataat    63540

tcagtcttct gatctatgaa gatagtatac gctgtatacc agtctttcaa taaagtttaa    63600

aaatgtttcc atgaggtttt tataattttc tccataggat cttgcatatc ttcttaaatg    63660

ttcttttctg gcatttttgg ctagcatttt gatatttaac atttttgtat ctagaaatgt    63720

ctcttattaa ttctaataat ttatctatac aatgttttaa attttctaac ataatcacat    63780

catgtgaaaa taacaatgag tttaatttct tcttttcttt cttttttttt tttttttttt    63840

tgagacagag tctcgctctg tcacccaggc tagagtgcag tggcgtgatc tcggctcatt    63900

gccagctcca cctcccgggt tcacgccatt ctcctgcctc agcctcctga gtagctggga    63960

ctacaggcac ccaccaccat gcctggctaa ttctttgtat ttttagtaga gacggggttt    64020

caccgtgtta gccaggatgg tctcgatctc ctgacctcat gatctgcctg ccttggcctc    64080

ctaaagtgct gggattacag gcatgagcca cccacgccca gcctaatttc ttcttttcta    64140

atccttatgc cattaggttc tttttactag atcactgtgc tagttaggac atccagtaca    64200

ctgttgaaaa gaagtgttaa taacaggtat ctttatcaat tttctgatcc caaaaagaat    64260

cctttcaata tttcaccacc tctaacaatt gtggcaggct ttttttaaag ataagaaatc    64320

tttatcagtt caggaagttc tcttttatca agaatattta tcatgaatgg atgtttaatt    64380

ttatcagaca attattctac atgtattgag ataatcatgt attttctcct tcaatctgtt    64440

aaagtggtga attatattaa ttgattttct aatgttaaat caactttaca ttcccagctc    64500

aaacctagct tgatcgtgat gcatttttta atacattgga agatttagtt tgctaaaaat    64560

ttgcttaaga tttttttatc catatcaatg agtaatattt gatctataat tttcctgact    64620

ttcattgtcc ttgccaggtt ttggtatcaa ggttccaaga ttatgccatt ttttttttaa    64680

agccaagggg gccaggtggg gtggctcacg cctgtaatcc cagaattttg ggaggccaag    64740

gtgggaggat tgcttgagga caggagttgg agaccagcct ggccaacagg agaaaacccc    64800

atctctacta aaaatatata aattagctgg gtgtggtggc acacacctgt aatcccagct    64860

actcaggagg gtgaggcatg agaattgctt gaatcccaga gacagaggtt gcagtgagct    64920

gagatcatgc cactgcactc cagcctgggc aacagagcga gactccgtct cattgaaaac    64980

aataaaaaga aggccagggg cagtggttaa tgcctgtaat cccagcactg ttggaggcgc    65040

aggcaggcgg atcacctgag gtcgggagtt cgagaccagc ctgaccaaca tggagaagac    65100

ccatctctac caaaaataca aaattagcca ggtgtgatgg tgcatacttt taatcccagc    65160

tacttgggag gctgagggag gagaattgct tgaacccggg aggcggaggt tgcggtgagc    65220

tgagattgca ccattgcact ccagcctggg caacaagggc aaaactccat ctcaaaaata    65280

aataaataaa taaataaatt ttaaatttaa aaaagaaaag gaaagaaatt agctgggcat    65340

gatggcacgt gtctgtagtc tcagctattt gggaggctga ggtgggagga tgacttgagc    65400

ccaggaggtc gtggctgcag aaattacagc ataaattaac tctccattag ttaacttaat    65460

caaagccaaa agttagctaa aatctttaac cttcctccaa gacaactttt cattccagat    65520

atcctttccc aatttattgt aatgataagt attttaattt tatcttgttt ataaaaattt    65580

ttattaatca atgaaaaata aagctaccta ttatacagac aatctctaaa actgagtaac    65640

tgaccccaat aaaggtttat ttctcactcg tatcatagcc taatgcaagc cagacagctc    65700

taggtgggac tccaagaagt gactttgcca tgcctgaagg aggccaatat aacttcaaag    65760

tttgcctcct gcttgtggga aaatggaaag ccaaggtttg ttttaaggtt taaacagtga    65820

aaggcttttt cagtcaggga ttttgattta tttcacaata caattacttc aaaaacttag    65880

atggcttcag acctctcatt gccacacaaa gtgctttctt tgacaaagtt ctcaattgtt    65940

ctttatttct ttgctttcct ttccccatgc ctttctcttg cacaagaaac agtggctaca    66000

ccattactac aagctttgct aagagttgtt tcatttaatt ggaaaattta actagtcttc    66060

aacatttgaa gacttaatcc cattgctcac tgcctggaat ctagaagcag tacagttccc    66120

taaatcgtca aggctctaaa cttctggatt atattttctt ttattcttat aaaccagcta    66180

aatctttcct gagctaatct ctttcttgta ctgtcttgac caacatagcc aattacaact    66240

gacccacaat actaaggttt aataaaccct tcccctaggg ttgctggttc atgaggctcg    66300

tgctctgcct caaaattttt gccagcaata tttttgtcac tgaataacat agattgacat    66360

tccaagcctt ctcctatcag cttccttgtt gcccaccaca tgatcattaa gccagtgcca    66420

catagttgat gcttttgaaa aggcaatacc ttttttcaat gaagcaattt ctccattact    66480

caagataagt acaactagct gcagtgatac cctctaaatc tgtgagttaa cataatagag    66540

atgtatgtct cacagcacat tcagtgcttg ttgggaagct ctcctgggag tgtctacttc    66600

aagtagcgcc tcaaggatct aggattatcc catatcgtga tgtcaccatc ttcagttagt    66660

gacctttatg gtgaacatga aagggaaaga aaaagttcag ggggtttaag gctatgccta    66720

aaagtcatgt atattacttc tgtctccatc tccattccac cagacagaac ccactaacat    66780

gaccccaact atttgcaagc aaaactggaa aacagtcttc cgttgtgtct gggaggagaa    66840

aagtgaatgg agactatatg accagtctct tccacatctc acaagacatt gttgttgtgt    66900

ccactcaatg tttatttaga ttcactctca tgcttagcac tttcttgctc tttatacctt    66960

tgttatagag ccagtggggg ctcactgccc aatgctctag aagccaatac tatgactttg    67020

gaagccaaga cgaggacacc aggcttttga gaaaagaaaa gcttaatact gcaagctggc    67080

tggcaagaag acaggaggtc aagctcagat ctgtctccct gtgctgtctt caaggcagta    67140

tttttattag aaaatgttta gtgggtggat accgggattt gcaggtgatt ggtggaagga    67200

aaggggaggt ttggagagtc catgggcctg cacagttatc tcttcatgct tactcatggg    67260

ttgcatatgc aaatctgggg ggagttagta tgcaatatga agtggaaatt cagtccatga    67320

cgtcagcaag ctcattctgc acaaactcca gtcggccatc ctggttccaa ttgatttcag    67380

cctgtttttt catcatcaca caaggggagg gagtttcagt gtctcagcaa gttgtttctt    67440

tacctatctg ctatcctaaa aactcaagaa tttttgtaag ttactgattt cttactcttt    67500

ggaacacagt ttgagtttca gattttcagt gagttatttc ttatctggta tcctgtaagc    67560

ctaaaaattt agttattgat ttcttcaacc ctttggagca cagtttcaca ttcttgtata    67620

ttacacatta catattactt ctgggatcac tttctatcta cctgaagtac ctcctttaga    67680

atttctttta gtaagtgcct tctggccata acctctttgt ttatctgaaa tttgctcttc    67740

agtttgcccg tgtctttgag agacatttct tatgaatgta aaattctagt tgatacttta    67800

tcttccttca gtgaagatag tattccaaca attagcctcc attgttgcta atgagcagtc    67860

agctttcaat ttaactgtta ttccttcctt tctggatgct ttttaaatct tctatccatc    67920

tttggtgttc tgcagtttca ctgtaatatg tctaggtgtg gacttctttc catttataat    67980

gcttaagata tactgacttc ttgaatcttt agttttgtaa ttttcttcaa ttctggaaag    68040

ttcccagaca tgatgtgggc agtcatagcc tccacgccat tctatttttt ctccttctgg    68100

actttggtta gatagatgtt aaactctctc attctatcct ctatgtctct tacactattt    68160

tgttattttt catcttatgt ctctctaggt tacattctga ataatttatt ctgatatatc    68220

ctcagttcac taattctctc ccaaactgtg tcaaatctga tgcaaacctt cttcataata    68280

tttttaattt taagtattat atttttcatt tctaagagtg tatttttcac aacttgttat    68340

tgttatctat agttttttta ttctctgcac atagtttcaa gttattattt tatttcttta    68400

acatattata tctaattata ctgttatctc tgactaataa ttctatcatc tgaagaaatg    68460

gaatgactat ttccacatct gtggtttctt caagatctca ttcactcttg atgactcatt    68520

ccttctgttt ttgtttgttt ttttactgca actcttaaac aatttttgag ggaatagttt    68580

gaaacctgag ataaaggcag gttcctccag aggtatttgc atttaattct gcagagcact    68640

ttgtagaatt gctctaaatt aaattctcaa cttaaaatac ctaggtagtg tgaattccag    68700

ataaaatcct atatgagcac cactttgttg tttcaaatgc tcagcgtcaa ttttcctcct    68760

gtagctggta cctaacacca gccattcaat tttccttgca ttctcctggg attgtttgtg    68820

gttcatcctt acatgaaggg tatagctctt tgggatctag tcttaaagca gggagaaatt    68880

cctgctaggc ttacaacctt cggcaggcca tggactacgt ttcctgctcc ccatactagt    68940

tactaatgct cagtttttat ttgtgtttat cagctgcctc tgtgaccagt ccacagagtt    69000

gttgttttaa gctctgcttc ccatatgagg agagtaactt ccagattggg tgtaaggtga    69060

acgtggaccc gctctccccc atcacataaa gaggtgcata cagcacttac tgtataacag    69120

gattaaacct cctcccgtgg gatttactca cggatatggg tgataaaatt gtagctacac    69180

tgttgtgttc agcattgcat cctagcacct aagccacagc ctggctctta gtaggtgctc    69240

cataaacaca ccttgactga cagactgaca gttgagctca gatttttttt cctgacaaat    69300

tagagaacca tacaaatata ttttaaaaca catacatttt tatgcttgat gattttgctg    69360

tcttgtggga cttagcatat ttgagtttac agtgaagact tttgagactt catcttttct    69420

cagtaactaa accattggtt ccatgagagc aagagcccac acacctctct tcatacacct    69480

cataggctag cacactgcca tgcacctgca cggctggagt tctggggggt aggttcgttg    69540

gtcaattaaa tcaacttatg aatgctgagt ccatgaaatc atggacattt gcagtttcaa    69600

agctggtggg agcaacagat gttgtccact gccccaagat gagaaatgcc ctaagagatg    69660

ttttgccaat acctatcgaa tgcagtgggt catcccctac ccgaaggagg ctggtctctc    69720

ttcagtcata aataagcttg ttctcactta tttgtgagcc ccatcacacc caccccacct    69780

ccacagaaga ggcccatatt caggagggat caggcctgtg gctatagaac agagtacaga    69840

tcgcaaggcc accaccccag tagaagaccc tgactcagcc acagtcaatg aagcacattg    69900

atacttatga accatagaag gcagatcata tttttgagta atttatagca taggaagaaa    69960

ggtctccaaa agcagtgtcc agaaaacgcc ctggtttaat gggatgagag gccttgtgtt    70020

tttcccagat ctttggtttc caggcaaaac tttagatgaa aggtaatgag cacagctacc    70080

aaaacctgac ggtctctgtt tctctgcagc tgcgcgtatt caagctggcc aaatcctggc    70140

ccaccttaaa cacactcatc aagatcatcg gaaactcagt gggggcactg gggaacctca    70200

ccatcatcct ggccatcatt gtctttgtct ttgctctggt tggcaagcag ctcctagggg    70260

aaaactaccg taacaaccga aaaaatatct ccgcgcccca tgaagactgg ccccgctggc    70320

acatgcacga cttcttccac tctttcctca ttgtcttccg tatcctctgt ggagagtgga    70380

ttgagaacat gtgggcctgc atggaagttg gccaaaaatc catatgcctc atccttttct    70440

tgacggtgat ggtgctaggg aacctggtgg tgagtggtga accctgctgg gggcactgtc    70500

tcctggggaa aggagaaggc ttctgggtta tctgaaaaag ctttgatctg catttttatg    70560

cccagattgt acttctctgg ttgaaaagtc ttcaaacttt tcaaattcat gtgggattca    70620

ttacaagaag tgtgccttgg gaggcagtct gacttgcagg aatgagaaca tatgattaga    70680

aaagaaagac ctggtgtaga atctctgctc caccatttac taggtgggtg accccaggca    70740

agagacttaa tctcctcaag atctaatttc cttaaaatca agaaaataat gcttactcat    70800

gggtttactg ggagaattaa atgacaggag atgacatatg caaattgcct aatgcaatgt    70860

ctgggctgag gcaggaactc aataaacggt gtctattagc tgttaaagga aaaatgtcct    70920

tccccaatct gagggggctc agaaaacatt tttattcagg gaagtaagag ctgactgatt    70980

tctccaagct gcacaggtcc tagctgggag cagggggaga ggctgcaggg agggggcaca    71040

atgggtcacg gacaacatcc aaggccacag aaataataac aaaatctact ccatgtttgg    71100

aggaagcccc tctggagact cacttgccaa taagccccaa taccccttct ccgccccagc    71160

ctggccccct gccctcagct tgtctccacc cactctggtc atggtggggt ccttgccctc    71220

ctgggactga ctggttgtgt gggaggatgc agtcttccag aagccccttt cttattgccc    71280

tggacatcaa ccaacttggg ttctttcctc atgagtttta tagacagaag aaagctaaac    71340

caagaaaagg gaagcaacaa caaatccaga ctctttagtc ttttccaccc tggtgcctga    71400

gccagggatg cctctgcctg catcccagaa actctgttct tccaggctga gcccaccatc    71460

cctgcagagc cacagatgcc cctcaccctc agacaggaag tttacccctc tgagcacttt    71520

tacatttctc atatcatttt gtcttcacaa ccgctcttca tctgctctca agtgaagaac    71580

tggaagcagc aagatgtgcc caggattcca gagtcaggaa cagagcccag ggctttggca    71640

catgagggtg gttgcaggaa gggctggtgc cttctctctg ttgtccctaa atgtccctct    71700

gctcagcggg gggctcctcc tttatggtgg aaaatatgct tccaagcctc gtccactgag    71760

gcgggtcact ccaggacatc cccaaacttt ccctcaactg ctctcagaaa gtccattccc    71820

ccaaaaggga cagcatcccg ggtgggcagg aagaggccca ggccgtggct gtcttgccag    71880

ccagctgcta acccggtagg ccaatgtggg gctcagctta gagattgatc aatcttccct    71940

tccattcctt ctcttcaggt gcttaacctg ttcatcgccc tgctattgaa ctctttcagt    72000

gctgacaacc tcacagcccc ggaggacgat ggggaggtga acaacctgca ggtggccctg    72060

gcacggatcc aggtctttgg ccatcgtacc aaacaggctc tttgcagctt cttcagcagg    72120

tcctgcccat tcccccagcc caaggcagag cctgagctgg tggtgaaact cccactctcc    72180

agctccaagg ctgagaacca cattgctgcc aacactgcca gggggagctc tggagggctc    72240

caagctccca gaggccccag ggatgagcac agtgacttca tcgctaatcc gactgtgtgg    72300

gtctctgtgc ccattgctga gggtgaatct gatcttgatg acttggagga tgatggtggg    72360

gaagatgctc agagcttcca gcaggaagtg atccccaaag gacaggtaag agttatcccc    72420

aagggacagc cacaggcagt ggggaggggc ttcagggctt gagtgacaaa gggcaaaagg    72480

gaaatgcaga ggagaccttg acataaagaa gtttaaacca tgccaagctt tccagaggag    72540

ttggcgtttg agcagggcct ggaagaaaaa gtcagaattc cccaggcaga caaacaggga    72600

gtggggggca gcaggtgagc aaaaggccac cttgaggtgc ttggggattg tctttcacac    72660

agctgtccca tgcgctctgc ccaacccagg ctctgtgcat gagatgctaa tgagatttct    72720

ctaagaacag gatgttgtcc aagagcaagg ctcatctaat ctttaccagc atcctaagaa    72780

gtcctgattc ttatgtgact catttagcca gcttttcccc acaagtggta tcacagggaa    72840

atgacacgct ccttttggca ccaactaatt taaagcacat ttgagccatt tgataatata    72900

tatttttaaa tacttggcac tattccttac taccttaagc tggtatatca accctcgcta    72960

acctcttctc agtaactcag ggcattcacc tctgcccaac gtgggaaggc agggaaccct    73020

gtgaggcctc aggaacatgc agggctgctg gccaggttac taagtggtcc agaaaagctg    73080

tgctttgagt ctgtagctct cccatagcct tcttccctgc agtcgtcact tgtgttccag    73140

cagctgctgt tatcagctgc catattttac atgcctttgt ctaggtaaca gcagagagca    73200

tgaactctgt gacagctgtc tgccactcag aagcattttc agttactttg gggctcttag    73260

ggagctccag gtggccaagt tccctacaat tttgacctct ggacaaataa caatggtcat    73320

ggctaaaatc tattgagcca agcacttcgt gcaaagtgtt ttacaagcgc taacatattt    73380

agtcatcaaa acagctgaat gatgcagatc tagccttttc aattttgaag ctgggaaaaa    73440

tgaagattag agaggttaaa caacttgcct aaggtcacac atcttataat taatggagcc    73500

caaggataaa acataggtct atctagctat agtcttcatg ctcacttcac acacgtgtat    73560

gtatatatgt atgtacatga gttgcatata tgaaactctt ggctctggca gcctgtgatg    73620

tgcaagatcc cttcaaattt agaactggtc atctaagggt ggggccaggc acccagttgg    73680

gaccctctct cactagcagg agcagctgca gcaagtcgag aggtgtgggg accacctgac    73740

acccaggagc ccaggcactg gaacatcttc tgaggacctg gctccatccc tgggtgagac    73800

gtggaaagat gagtctgttc ctcaggtccc tgctgaggta ggtatgtcag cttcctggag    73860

aggttggaca gccagccaga cactgagcag tgggctggta gaggctggag ggtggcggtg    73920

aaggtggggt attccagact gcactcaatc acataacctc atttcttatc ctgggaattt    73980

ttaaagtccc tcccaacctc cggctaatcc gcacaatttc aactttcacc atataccatt    74040

gccacaatct cactccaggg tggttctagg tatagaaaga aagagtgaga ctccacaagc    74100

tgtgggacct aagatcagtt cccaaacctc tctgagccgc catttattca tctatgaaac    74160

tgaatggtaa tgcctacttg gtaggattat tttgaagctt aaatgagatg ctgcttgtca    74220

aatgtttagg tcctgcctga gacaaagtaa gtgcccagga aatgacagcc aagaaaaaag    74280

gaaacgaaag acaacgcaca aagaaagtca aatatctttc agagccagca aataagagtt    74340

ggaggtgctc acagatgaag aagttttccc ttgtgattct cccccacttt cttttgtcca    74400

catcattttc tctaggcaaa agtagcctgg ggctagggag aggctctcta taggtgagta    74460

gtgaagtgac agcctcacag agactgagct ggaagattag aggtttagga ttgtcttata    74520

caaggtaaaa ataaatgtgg tttcacttac aaatcttgaa ggaaacaagc tatagggaaa    74580

gaggcatcta taaaagttta gcatctttaa taacactgcc ttcaattcaa gaatttaatt    74640

tgacacctag ccactgagtg ctgactttgt gacaggcact gggctcaaca gagataagga    74700

agtcataatt catccccaaa gttatcaagc ccttcagctt gaagaatgtc agctactggc    74760

tgtgtgccct aggcaaggct gaccacagca gggtaagata agagggaggg ctgggacggg    74820

atttgggggc tgtgggtgaa cagaagccgc ttggttccca ctgggtgagg gctgtcacat    74880

tctgcacgtg gatgtcatgc ttcttcccaa atgttccaag gactcccctg gctagttgtc    74940

cctactcaat gttttcagta cacaacttct gggtgttggt tttttgtttt tgttttcttg    75000

tccatgaccc cggctaggca ggaggggcct gacagcgaca aatggggacc cgccccacca    75060

tttgggtcca ttagcaaagc tatcaggttt actaatatga gagcaacttc aacccctaat    75120

tgaattcatc tggagacatt atagggctgg agctgccagg agggcagcag gcccctgcag    75180

cattactcca tgattaaata ttcaagccca gtgaatgctg agagtcgtta tgggtgtaat    75240

tacggtgtct cgggccattg ccagcactcc atcaggggcc ccgaaggttt acagtctcac    75300

acagctaagc ctctggggct ccagggagaa gagcagtgtt ccaggcctca gctggcgagg    75360

caccaaacat gggtgcagtt gaacctgcag tgaccgtgtg caattccccg ggccccgcgg    75420

agagacgagt tcactgccct gggcttctcc cctgcaggga gtggacgaca caagctcctc    75480

tgagggcagc acggtggact gcctagatcc tgaggaaatc ctgaggaaga tccctgagct    75540

ggcagatgac ctggaagaac cagatgactg cttcacagaa ggtgaaggga cagccacagg    75600

ccccctcaca ctgatgttaa ttagggccag aatccagttg agcgaacact cacctgggat    75660

ccacagaaga caaacaagct gtgcccactt gctgcctcac tcccaggctt gagggcgccc    75720

gcatcagaca cacatgcccc aggtggcagc agcctggccg tggtatctgc atctcatgcc    75780

ctatcagaca ctacggagag acgtgggcct tcctctttac cctcaaaaac ccctccgtga    75840

gttctaaacc agccctcttg agttgaaagg gggaaacgta gtcaccacca taaacaccac    75900

tgaaaactct tgatttggac catgaaggac ccagaggaag gccatgatgt atctgcttcc    75960

ctcaatcttt tgtttagctc tcaaaagcag aacctgtgtc ttagtcatct ttcctctcag    76020

tgtttagaac agtgaggcac attacattct caataaatat ttgtgcaatg aatgaatcaa    76080

gagtccattc tataaaggga attgtggcct caatgctttc taaaaataca aagaaaaatt    76140

ttttaaatac ttgagttttt attaatagtt ttatttgacc ctgggctggg ctgagctggg    76200

ctggacccaa tccccatccc agccacgtcg tggccctcag ttcagcttgg gcttggagca    76260

tatccccctc aggcaccccc aggctcatac gccgtagctt gtctgttttc caggtatagg    76320

tgggcagaag gacagggacc actggtgtca tctgtaagaa ggatatggct aggaaaaaca    76380

tcagagtggg caagactgat gatggagagg aacacctgtt ggtctggatt gagggactcc    76440

ctggaaggga cccctcttca cccatattcc aggaaagaat ttttttccaa gggcatgaca    76500

agtgggtttc ctagcagaat ggtttctctg cagcaggagc agaaattatc ccctttgccc    76560

actggccatc acccaccatc agtcacctct ccccacagga tgcattcgcc actgtccctg    76620

ctgcaaactg gataccacca agagtccatg ggatgtgggc tggcaggtgc gcaagacttg    76680

ctaccgtatc gtggagcaca gctggtttga gagcttcatc atcttcatga tcctgctcag    76740

cagtggatct ctggtaaggg gaggcatagt ccctgccccc aaatcctcca gataggaatc    76800

tcctacaatc caaaggccct ggagctgcat cagtgggttc tcctgactac tgagctgaaa    76860

gtccccaacc ttgtcactag aaggagagct gcagcccagg gcgagggccc ctcttagcag    76920

cagagcatgg gaggtgttca aggtgcccgt gccatggcct gccaaacctg gctgcaagca    76980

tttgagtgag tgagtgtatg cctcccacta tatagatggg gaaactgaca ctcaaaatgt    77040

ttaaaaggct tgtccaaggt cacccaactt gtcagtagca aaacccagct ttgcccttat    77100

ttaatcccga agcccctggc ttcccaccct ctgacctccc caacacacgg ccttctctga    77160

aggcctacaa tacaaaaagg actatctttc cttatcaaac cacttccaaa tgctactaat    77220

tactccttta aagctcacag aaaatcatta caatagcact tctcaaaatt taatctccca    77280

ggagcttgtt caaatgcaga ttctcattcc ataaatctgt ggcagggcct gagaatttgc    77340

atttctaaca agctcccagg tgatgcttgc actgccctca gtgacccaca ctttgaataa    77400

caaggcctta tgggaataga gattcagagt tgggagacat ctctaaggcc ctggctgaat    77460

actgggcttt gtagagcaaa gaaggaaggt tctctctgta ctgtggctta agctccttac    77520

acaatctcaa ctactccgcc aatagaccaa ggtagacata gacacaggaa ggaacttaac    77580

atcctcagtt gtttgcattt tctaaatgag gaagtcaaag cccaaaggca tgaggggctt    77640

caggtaatta gttgaagggc tgggaataga gagttcaggg tggcagctaa ttagttgaag    77700

ggctaggact acagtcccgc tcttccgatt cacggctgca gtgttttcac tcatcttgcg    77760

cctcatgtgt catttactct ctaaaaacaa cctactaaat atctaggcct ccatctaaat    77820

gccagattgt ccaggaaggg tgacaaaact gctcggtgca tggcctcagc tttagggagg    77880

agcacaggtg cgggacgagg caggatctga gaggtgggag gaaaactagg gtggcaatga    77940

cgcaaagcca agggagaaga gagtttcggg gcagggactg gtctgccatc ctgggtggag    78000

ggggaactgt gtgacagcgg ctgcaggtgc ccagtgccct ggcacagggc agtgattgtc    78060

cacacggacc tcagcacagt gtagaggcca aattgcaggg gcaagagagg gctgggcagt    78120

gctttctcca cacctatgct cttctccttc cagtcctgct ggattaaagt aataaccaca    78180

tgtgctgttg gccaggtgct ctcctcacta cgtcattggc ttgtgggcct tctctcctca    78240

ttttgcttct ctgctctccc ttgctccctc ccttctctct ctagccccct tctcttcaca    78300

ccccggtcca ccccccacat tcccaggagg aagctcagac ctgcagcact gcgccagccc    78360

agcccgcccc ctgcagctct cccttccctc ccatctcctt cccctgggac tgaacaggct    78420

ggcaccaaat ttagccttct ttaggctttc actttgagta ccttttaaaa ataacatgca    78480

ttttcatctg acaaagtaaa gtaccaaaaa aatacttgga aattatagaa aaaggtaaag    78540

aaaaaaaaat catccatttc cctatcactc aaagagaaac tcacttgaaa acatgctggt    78600

atacctcttt ctcatcttgc ttatgcataa aatatacaca tattacaaaa ataaaaccac    78660

atttatgcat tctataacct cagtacattt ttctcagtaa atagtctcat attatctcat    78720

ttaatggcta taacatattc ctttataatt tactcaacca atctctatgt ttacttctaa    78780

tacacattga atattccctg tgtgtactcc cttagagacg ttggataatc tcccatctta    78840

gtcctcgtcc tagacacaga atcggaagct gagaaaagat gtgggttcag ttgaaatccg    78900

gcttcagctg atcccatgga aagccctgaa gcacaaagga caccaaagag ctgtcccacc    78960

ttgaggcaaa gaagacagcc ttgtaaatcc ccctgtcact gtccctggct gagggctgcc    79020

ccagcgggga ggataagcat ttcccaaggt ggacacagtt tcctccagcc cagcgaagcc    79080

atcaggaagg gggtgtctgc atccatgaac tattagcagc cgacactccc agcagatgaa    79140

ggataggggc actggcccct taaagaggac ctgagtgggc accaacagcc tccagtgtcc    79200

ttaggattag tgcttgaagg aggaattgct aggttcctga aacctctgag tcacattgcc    79260

aatttggctt cacacaggac tggccaggtt ttcactcctg ccagtcactt gtaagagtgg    79320

ccgggcgcgg tggctcacgc ctgtaatccc agcactttgg gaggctgagg cgggcggatc    79380

atgaggtcag gagatcgaga ccatcccggc taaaacggtg aaaccccgtc tctactaaaa    79440

atacaaaaaa ttagccgggc gtagtggcgg gcgcctgtag tcccagctac ttgggaggct    79500

gaggcaggag aatggcgtga acctgggagg cagagcttgc agtgagccga gatcccgcta    79560

ctgcactcca gcctgggcga cagagcgaga ctccgtctca aaaaaaaaaa aaaaaaaaaa    79620

aaaaaaaaaa aaaaaaaaaa aaagagtggc agccccccac agccacagca tcctagggtt    79680

tcccctattc ttttccatct ccaccagtct gataaaagaa aaacagcatc ttcttttaat    79740

ttgaatttcc ttgattacca gtgagataga acattctttt tcagaggtgt gttggcgatt    79800

cttactttca tttttgtaaa ctgcctgtga acatccgttg atgcttttat ttttaaacaa    79860

agtcactgtt agcatccctt tggttcactt ccaaaatcca atttgagaag gttttctttc    79920

tcccttgcat tcagcatccc tgcaagtatc agcagggctg tttgtcccca ttggccctga    79980

agaagtcatg ctttggatct cacagtacct cctccactat cccactttac ctccccacag    80040

caaacaaaat gctactggca agctgactac caaatcccct tccagggact gtggtcaggg    80100

ctggctgggt ccttccctat cagtctgggc cccagtgctg tgggtccagg cagcctgcca    80160

ttctgcatcc tttcttcctt ccaggccttt gaagactatt acctggacca gaagcccacg    80220

gtgaaagctt tgctggagta cactgacagg gtcttcacct ttatctttgt gttcgagatg    80280

ctgcttaagt gggtggccta tggcttcaaa aagtacttca ccaatgcctg gtgctggctg    80340

gacttcctca ttgtgaatgt gagtggctca gtgggaacac gtggggtttg gggtcctccc    80400

ctctgactcc tggctacagc tagggcaaag gaagctcaga gacctggccc tcaagggcta    80460

ctccaaagaa aagttttgag catttagtga ggagtctgag aatagccctg acacccatga    80520

gtggtaaagt ccaggcagta tgtgactgtg acacaatagt gactgttagg tgagttatta    80580

ggtctccatt cagaaagatc cctgcaatcc tctgcatttt tacatccaaa gtgagatgac    80640

acatgcagct ctcagaggtc ttatggccct gcatccatag atgggtcttc tggaccttgg    80700

ggagccatga actgtgagca cagagaatct tcccacctgc ggttctgtgg tcctcacacc    80760

tggctgcact tgagaatcac ctggggagct atgaaatatg cagtgaccga ccaccactac    80820

cccagagatt ctgatcttat tggtcttggg tggtgcccag gcacctgtat tttataaatg    80880

ctcccaggca tttccaaggt gcagccatgg cttagaacca ctgagcttat actgctgcct    80940

cctccccagt ggcattgaaa agaacagagg gcgcatttgg agaggtaatg agctggagtt    81000

catgtgttca cactcatggt aacctgtggc cagtaatccc tgcattagag aattgactgt    81060

gtgcttctca cacatcagac atgtgattcc tcagtcatct cttcctcatc ttaaccacca    81120

cattgcacta tcactgtcta ggccactacc ttctttgctt tgcagcatgg ttaactgagt    81180

tatctgttca ctgccgcata gctgagggtt tctgcaagca gggtgaggca tgtgctgtgt    81240

tggtctctgc ctgccccact caagcagctg ccagcagcaa ggtctgccca gcagaggtgt    81300

caggaaatgt gtctgtattt ggtgcttgcc tcctgaagct ggatgaggtt cagcacagaa    81360

cattctgtcc agcctcctgt gctggcaggt cctccatagc aggcctgtgc attcaattct    81420

cttcttccct gatgccaatg cactagcagc ttcaggccac tgtaccacaa ggattagctg    81480

tgaggcctga aatctgagtc atgggtgata attctgtgca tatgaaataa ttattcataa    81540

atgaaaggaa aattatttat tccggtgtcc cacccctttg ggggcacagt cactcctgct    81600

tatgttgatc tcaccagtct cagtcctaat caccttaaac ggtcatgcac tcatttcatc    81660

catcttccta ctgattcttc cttccaacca tccatccttc cttccataca tttcaccttt    81720

tgtatccaac cattcagtct tcctttttcc ttcctcccaa acatccatcc atctttattt    81780

cttccagctg tacatcttca tcagtcctcc ccttccatcc atccattccc attcttcttt    81840

ccctcttctc ttctgcccaa tcttttattc taaacttcct tccatctatt catcatcctt    81900

aacccttata tctttctatc ttttgattca ttcttctatc caactgtcca atcatctaac    81960

attctgttca ctcattcacg catcttccat ccaagcatgc ttctactcac tcatccttct    82020

atccactcat tcttctatct ttccattctt gtttcaacct atccatctat tcttcctttc    82080

ttccacttat ctgttcattc atccctttcc cttccattca tcatccattc atccatccta    82140

tcaaccttcc agtcattcac taatttattc cattcatcta ttctgtccag ctccccatct    82200

ttccattcat gcattagtca ttttacccag ccatccatcc ttctcttatc cacctatctc    82260

atctatccat tcactattcc ctgctttcat acttttcctt tcttgtttgt ttctcccatc    82320

cttccattca actatctatc ctatccatct ttttgtgtct gttatctttt aaaattttaa    82380

aaaatatatt ttattgtata tatttgtatt agtctatttt catgctgctg ataaagacat    82440

acctaagact gggcaattta taaaagaaag aggtttaatt ggacttacag cttcacatgg    82500

ctggggaagc cttacaatca tggcaaaagg aaaggaggtg cgagtcacgt cttatgtgga    82560

tggcagcagg caaagagaga ggttgggcag ggaaactccc ccttataata ccgtcacatc    82620

tcatgaaact tattcactat catgagaaca gcatgggaaa gacctgctcc catgattcac    82680

ttacctccca cagggtccct cccctcccac aacacatggg aattcaagat aagatttggg    82740

tggggacaca gccaaaccat atcaattttt aagggataca aaatgatgtt ataagatata    82800

tatatatata aatgattact atagtggaac atattaacat atccatcatc tcacatagtt    82860

acccatttct ccccctgtgg caagagcagc tataattact cagcgagcaa aaatactgaa    82920

aacaatatgc tattattaac tatagtattc atgttataca ttaaatctat cctatttatc    82980

attgtatcct ttaattcatc cctctatgca atcacccttc aacttttcat ccagctgtac    83040

ttctttcttt ctttccttct agccatccca atgatcctat ttttcttcca tttgctatac    83100

atctaactat tgaatacagg attgtcttat gaagtgcttt gtaagaaaca gaagcacaga    83160

ataaatactc actatctcca ggatcttaca ctttagtctt tcagcagaca agacacacat    83220

ggaaataaat gtattataag ggtgaatgtg ttgagcactg ctgggggcaa ttagtatctt    83280

ggagacacag agacatgagc cttcttccac tcttggggtg gggtggttga gaattcttcc    83340

tatgggaggt ggcattagat gtggggcata gaaatgagca ggaccaagga gctgcgagag    83400

gactggggaa ggcccgtctt agctaaaggc tgaccttgaa caaaggcaca gacacaagta    83460

tgctcaggga acaatttgat ttgggtagaa tgtgtgggtg aaatatgact ggaaaagtag    83520

gttgtgacca tatgacacag gctacagagt atggagttta tcctgagggt gataaagtac    83580

cagtgatgtt tgggagtaag agaaagacat gatcataatc agatttgcag tggagaatag    83640

atgcatggtg cagtactagg gcctggagac tacttgggag gctagtgggc tgagcagtgg    83700

gaatggaggt gggcttgggt ggacagactt tgctggagag gcacagcacc tgtctgcccc    83760

agctgcagat tatccatgtg aggcagactt cccagggggc tgagcaaaag actgaatagg    83820

gttcagcatg gaactggccc caaacctccc taccctcatg cacccaggca gctgggtctc    83880

acctgctgat gtctggagcc ttgcatgaat gaaggaagag ggtcccttcc attccggttc    83940

tttgtcctgg tgcaataagc cactcatcca aagaatggac attgcttggg gctctgccac    84000

tcaagtataa agcccttctt ttctgaagct cctgtgtgca tcccacctaa ctgccaggat    84060

aagctgagcc tgaattcagc ccaccatctg tggtgtggct aagatctcac aggacagggt    84120

catagcccgt atctatgaca tctccctggc accttcaaag ttcctagcag gggaactttt    84180

ttcatgtaag tttctgtcct ttgcagtctt tggaccacca cttaaagaaa actgacagac    84240

caaaaggggc tcacaagtca gtcattatat ctcagatatc tattgaagct agatctcatg    84300

gacccatacc agaaactttt tgaagaactg cagagctatc agaactttgg aattctctta    84360

gtctgacttt ttcattttac aaagggtgaa agtaccctgg actagccagg cactaaccca    84420

agctcacaaa aaatcagggt tcaaatggga attagacccc acccaaacca ctattctttc    84480

caccccactt ctctgagcaa atataattca gattactata ttcctcagaa tagactctca    84540

gcatagcccc taggagggaa catcatgtct ccaagtctct gaaaatcagt ttcaaggttg    84600

ttgaggcctg actgctgccc ctagaaggaa aaggaagagt tgatttaata cactggaagc    84660

ttggccacct acgtaccaga ggttggtgat gttagagact gagtttttct tgcccagatt    84720

gtttaagaga gtggtgaata aaatttttaa taaaagggaa gagacaaaac tctttctaga    84780

cctctcattg gagttccgaa taaggtggga gctaggatga tggcttagac gtgtaggaat    84840

gggaggctgg gcagggagtt cctgtctcct tccacgagga ctgcctttct ggaaacctag    84900

agtgatgttt ctgccctctc ctgcactcag atctcactga taagtctcac agcgaagatt    84960

ctggaatatt ctgaagtggc tcccatcaaa gcccttcgaa cccttcgcgc tctgcggcca    85020

ctgcgggctc tttctcgatt tgaaggcatg cgggtaagtc tgatctcaaa acttctctca    85080

tctggccagg cacggtggtt catgcctgta atcccagcac tttgggaggc tgaggcgggc    85140

ggatcacctg aggttaggag ttcaaaacca ccctggccaa catgccgaaa ccctgtctct    85200

gctaaaagta caaaaatcac taccaccacg aggtgtggtg gtagtgagcc gagattgtgc    85260

cattatactc cagcctgggt gacagagcga gactccgcct caaaaaacaa acaaaaaact    85320

tctctggtct gcaggttttg gtaacccttc cccctttatg ccctccatcc caccaaccct    85380

gagctccggg gccccacctc caaaggtagg ctctgagtct tcacttcctg ctctgacttt    85440

ggtggtgctg catgtcctaa ctctcttagt tctctttcaa gtctttttgt gggcccatct    85500

tcccttgtca cccataaata ttacagccac caggacccag acctcacccc ctttgctctt    85560

agtgaagtaa tcctgaatca tcgctccaca agcatctatt atctcaatca cccaactctg    85620

cctcttattg ccaacatctc cagaacatcc caagttctct gtctttccat gacaaatgag    85680

tctttcctct aatactccat gagtgacatc atcagctcat tacctcagct gccacccact    85740

ggaatgcttc ttctctccta cttaatgcaa tcatcaggtc ctgtaaattt ttcccttcca    85800

tccacccctt tccttatcca ccactgtcag cctccacctt gccctaactg cctccgtcag    85860

gacagaatgc tcacagccag agccttgtct tagagattgc tgattgacac ccacctcttc    85920

ctcataatta caaatggctc cccagcagaa agtaaggttt tgctttgctc cactatcatt    85980

ggctggaagt agtcatcata gcttcaaaaa caaaagtggg cttttgaaat taacttgtac    86040

ctttacaaac actaggaccc gaagattgaa atagtttgaa atttattcta ttttgtatct    86100

aatagattct catttgctta tttacaaata agctattttg tgaatatgga tttaggtttt    86160

cactggttct tgaccacggc atactttaaa ttgtatttaa attgtgtttg tgttttatgt    86220

atggtattta aggagaataa gtcaaggttc tagaagtctg tatgtgcaag tataatacac    86280

acactcacac ttctaaatga gtgcagtatg cttgtaaact catccatctt ctcactgcaa    86340

cccaccctga atgaggttaa gggaagaagg tctaaatcca tcttcagctg cccaatgtct    86400

ctcagtcttc tgagtctgaa ttattgcact aattaaccca cttctcttgc ttcttccaaa    86460

ggccactggc tcatgaagca gcctgaatga gtatagaaag agatagaatc cagcagaggg    86520

ggtggggcat tgggaggttc caggtctttc tctatctccc accaggtggt ggtggatgcc    86580

ctggtgggcg ccatcccatc catcatgaat gtcctcctcg tctgcctcat cttctggctc    86640

atcttcagca tcatgggtgt gaacctcttc gcagggaagt tttggaggtg catcaactat    86700

accgatggag agttttccct tgtacctttg tcgattgtga ataacaagtc tgactgcaag    86760

attcaaaact ccactggcag cttcttctgg gtcaatgtga aagtcaactt tgataatgtt    86820

gcaatgggtt accttgcact tctgcaggtg gtgagtcaac catgagatca accatatctc    86880

ttgctttggc cgctcaataa aatggagagt ctaggttccc agaagatgct atgtggggac    86940

tttgcaagga gtagcactca gtgtgaactg aggtcattct ctattcctac agactacacc    87000

atgaggctag agggccttcc tagtgaatat gatatcacag tggtgcaatt acacaagtgt    87060

gggctagtag aatagcataa agggatgggc ctgccatggg attatcaggt ggtgagttaa    87120

aacacagaac ctgtacaaaa tagacacggc atagccacat gttcagtctt caacttcaca    87180

tcatttccta aatggtaata aattatgtct cattaggtct attgtaatga tatataatgt    87240

tggtgataat gacagtcaaa cacattcatc ctgtctttct ttctttcatc atccagtcaa    87300

tcactcattt cttgccttca tctacctgtt cattcagtcc tctgttcatt caagtgttaa    87360

tacaattact tatacatttg tcatgcagtt actcttgagt gtctacattc caccattggt    87420

tcttgcattt attcaacaaa taatctctga gtagctctgg tatgccaggc atggtactac    87480

tcagccctgg gagatacagt cagaactggg cttggacact gatgctgtat gagaaacaga    87540

ctaataggtg aattaaaaca gctcattaag tgctgtaaca ggcctaggag tgtaagaact    87600

aagatgtctt gcatgctctg aacatgctgg aaggcacacc cagtttctag acctcaagaa    87660

tgctaaagct gaaggcagga acatggaggt cttctattct caacttctcc atctggaaga    87720

tataccattc ttacatcatg tgcataaggt gggaaagtgg ctgagaaaat ggcagccctg    87780

agaggggaaa ccttaggcaa gtgcacagag cagacttgta gcaattggca ctagaaccag    87840

acacctagac actcagtcct cagtccatac tacattctga aaggctctgt gtctttaatg    87900

ctactctatt cttaaacagc cacatgtggg attactttaa atcatcatat gagattagtc    87960

aagtaaccca agggaacttt tcctttcatt ctttctgcac aagccctttc caacacagga    88020

ctctctcctc tctcactggg ccaccatggc ttgggaaggg tccagtatag atggatgggc    88080

agacactgag tggcctctgc tccttgtctc caggcaacct ttaaaggctg gatggacatt    88140

atgtatgcag ctgttgattc ccgggaggtg agtctcagcc cactgtccct acagccttcc    88200

cctctgtgca ttctacccat atcagtctgc atttgaaatg aagtgacgat gaccctggta    88260

ctggaagagg cgatcaccca gcaacctcac actgtccctc cttgcagcag tgtccagctg    88320

gctctctgtt gagtgtttca gccaccgagg ctttccccct ttcatctaca ctccccaggc    88380

ttctcgaggt tttcctctgt tcactgttga ggaaagcatc agataacctc taagagacag    88440

ttcatgtgag ccactccctg gacaagggtg ggagcaaagc aagggtagta gctaaatcaa    88500

ggtgcatagg gaggaatgag gtagaatctc aggaactatc ataaaaccca ggatgggcca    88560

ggcgcagtgg ttcatgcctg taatcctagc actttgggag gccgaggtgg gcagattgcc    88620

tgagctcagg agaccagcct gggcaatacg gtgaaacccc atctctacta aaatatgaaa    88680

gaaattagca gggcatggcg gcttgtgcct gtagtcccag ctgctcggga gactgagaca    88740

ggagaatctc ttgaacccgg gaggcagaag ttgcagtgag ctgagattgc gtcactgcac    88800

tccagcttgg gcgagacagc gagactcaat ctcaaaaaaa aagaaaagaa aagaaaaagc    88860

caggctgggg agacactatt ggggaatgac cacttcctgc tgtggcaggc actgtcaatt    88920

ccctgccacc tcttccctta gcccacttct gatttcacct gcaggctgca cttctgattc    88980

tctgtataaa gactccaggg cttaggagct tgtgcagcaa cttctccccc aagtaccagg    89040

gatttaatgt ccctaggggc aacccttacc aataagtttt gggagtctga ggataaatac    89100

tccagtttcc ctgtcccttg gtgatataat cctgcatgtg ctctacacag ttactcagag    89160

gaccccagta ggattgcgct tcagttgccc acaatgatgc cctgcttaac aacatcctct    89220

tcacaggctc ttctcccatt cccgcttatt cttccccact ccctcattcc tgcttccttg    89280

gatcacctcc cagataaatc acctgcaccc aggtccatgt cttaggcttg gctttcagag    89340

tgaacctgaa ctaagacacc caccctcctt cccactctcc cttgtctggt cacaggtcaa    89400

catgcaaccc aagtgggagg acaacgtgta catgtatttg tactttgtca tcttcatcat    89460

ttttggaggc ttcttcacac tgaatctctt tgttggggtc ataattgaca acttcaatca    89520

acagaaaaaa aagataagtg gtgctcagga gtttctggtt tctgctgtag tggtaagcct    89580

tatatttcct gttccctgcc cagctctggc ctcctgacaa aagccaacac tactcacagc    89640

ccatcacttt aatatcagtg ctaacccttg ccctgtgatt gctgttgcag gaagagttgc    89700

atttctctct gtcagcaatg ccccactaac atcctcactc aggattcaca tctcaaaggg    89760

atcttggtct tcccaactgg aaccaggtgt gttagatgtg ttccaagtga gccctgggag    89820

aatacaagca gggaaagaaa gggatctaga acttgctgac ctgttggggg atatgatccc    89880

cacaaaggac tgagtcaggg cacctcagga aaggccatgg cccagcactg gcagaatccc    89940

aaccctcctt gggatgggga ggaaggcttg tgcctccaag ggtgccgact ctgattaata    90000

ggaatcgaat cccagataac ctctcatgtt tataagaaaa tgtcagggca ataaaggtat    90060

aaagtatttt cctattatcc tttcatttaa tgccttccat acccctgagg tagataggcg    90120

ctgttctaga tttgcgtaac tgagatcccg agagaaaagg ggctacatgg ataagtcaca    90180

gagtacatgc aaacctgggt ttgcattcct gactcaacta cttgtggatg gctcatgctg    90240

gcaatatttt aaacccctct gagtctcagt tttctcattc attcaatggg gctaataata    90300

cctactctct ggattgtggt gaggggtaaa caaaatcctg aacaaagatc actgagcata    90360

agacaacttt ggtggtgcag tttctggcac tgtaacagca gaggggagtg tgactggcag    90420

cgcctcaaga gcaccagatg ctgttgctat taacaattta aaatatatac ctactagggc    90480

aggcattcca cttacaggaa atccttgccc agggttctga gcataagaag aggacaggat    90540

aggtctggga caagacagtg ctatttagta ccctggggag gtttgagatt attgaagcaa    90600

tcatttctct cattttacag atgagaaaac tgaggtcaag aaacagatta cagagggaga    90660

tattaggtaa cggaaggaga tgagctagtg accaggctgg ggtcactgag aaactgcatc    90720

tactgaatcc ttggtcagag ttctcagcat gacctcacct ggagctcacc tacccactgc    90780

ccttgccctt tccttctctc cccccataaa gatggtcctc ccaggaagcc ctttgtgtcc    90840

acagatcttc tcagatctcc tttcaaattc cacagatctc agcccagttt cccagcattt    90900

gcagggacta acttacataa acatgttatt aaaataggtg gctttcaaat tatgtcagga    90960

agctaaaggt gagagtttga atgaagaaaa tccaaagggc ccctaaagaa aaactaatac    91020

ccaatcctaa gggaggaaaa catcttcgtt ggtgcagttt ctggcactgt aacagcagag    91080

ggcagtgtga ctggcagggc ctcaagagaa ccagaggtcc ctctgagacc aaggacccaa    91140

ggataaggca gtaattgtcc tcatctcctc ctctccagaa aagatttgag ggcttctgtc    91200

cctcccagag tctttgcttc aaggtcctca ggaaatctct tgccccctgg gagggactgt    91260

gactctagaa gcccaaagaa ttttactgga atgaacaggc tagatccaag gctcagattt    91320

gaaccaacat gtaccttctc cttgagtcct gtttaccaac cctccccacc ctttatccag    91380

catctctgga tccctggaga acagaaactg gctttgcttt agagacccag gcagggagtc    91440

agcaatggaa ctcagtccca ccgttccgac actggatgtg gcaagacact ccttgatgct    91500

gggcttggtt tgtctatctg cagaggaggg gagaaggttg atatgatcct ttctctcctg    91560

cctgttctga ttttggtatc cgtagggggt tcctcttgct ttagtaacag tgtggccctc    91620

tctgcactta gggggccagg acatcttcat gacagaggag cagaagaaat actacaatgc    91680

catgaagaag ttgggctcca agaagcccca gaagcccatc ccacggcccc tggtgagccc    91740

cagaggtttc ctctagcaca gcctgtctgt gaatccaaca tgacagtcta tgcctgtgtc    91800

aggcaggggc ctgagggagt gctgtttatg gaagagaaga tctgggttga cgttgggatg    91860

agggtgatga gggttcctag gcccaaggaa tgagaagttc aaaagaagca actctggtct    91920

tctggagtaa acataccttt tacagctatt tgaaatgaat ctgttggggg aagcactgag    91980

tttctccaac agttttagag ttcaagtaca ggattggagg caggttaagc taagtgacag    92040

taagggtagt tagaacccag ggattaaact tgtgtggtta tgtatcatgg tctaggtcgc    92100

agtagatctc cagtatcacc ctatattcta ccccacgcct acaggtatag agaggaaatg    92160

acaacaaccc aactcccctg tcaggatcca agatgcagtc atggtagtgg tcaagtggcc    92220

cagtaggaac caaaagttat cccactcgag tttaaagatt gggcaaaaat tagggccaga    92280

ctctagtttc actccttttt tcataaagat ctcaagagac atggctttgc gttcctccat    92340

taaatgtact acccatacca cacatgatat cacctaagtt cttctcagtc ttctgccaga    92400

agatagaaaa catcaagcct ctgagaggcc ctaagatagc acttttttgg gaatggatga    92460

acaggtttgg gggtgaagat gttgatgtgt cagaaattat tgttgatcgt cttcaaagaa    92520

tttctgagcc atccactcca gtgaatggaa ttggccctgt gtccttctac ataaactttc    92580

tgtggctaag atgcagcatt agtgaagaaa atcacaggta ttgctgatga cacaatttca    92640

ttagcccttc cccacacaag ggaaaagtcc aaaggacatt taacaaagga acaagccttt    92700

ccctaaatga attatggaga catgcattct gttagccaag ctattagatt tttttaaatc    92760

aaggtatagg atttgcataa tttacttcaa actttgtcag aacaaagtga aaaacattta    92820

caagagaaaa aagtgatgac ttttgacact gtattttgaa atagtggtca tgaatttatt    92880

actagtctag attctgataa gaagtattac aatggggagt ggggagtgat aggaggttca    92940

gacctctgta ggggcacagc tttcttccta aatcacccat acaatcaaga taactggatt    93000

tgagtgaacc tgagcaaaag tccttaggct cattgagtat ccctccatca acaagttcag    93060

tggagaggag caggctcaaa attaaaatta ggtgaaaggc tgagtcccaa ccacattcaa    93120

gtcatgggta atgagaggag gaccctaaga cttactgaga agcaagcagc tgagtccaca    93180

ctggccttta cttgtggctg gagtaagatt gaatccacat ttgagccaga tgccaaggag    93240

gtgtgtgcta gggacaaccc ttggcaaaaa catgaaagtt tttggcacct tcccccacat    93300

actactcaat ctctctttga catcccagct tcttccctgt catcacccaa ccccataggc    93360

tgccaaagaa agcttcctcc cctcaaggaa gacaacattc ttaggacaag ataaatcata    93420

tttcaaaaag ggaccctgga gagggcatct acctacaaag gcatgaccct aatgttgaaa    93480

ttccaggcag taaataggag tgggagacgg agttgatggt caggcaggaa gacctgcaac    93540

aaaatcacca tttctcctaa ttaagctgca actaagatcc tccgaggatg gcacaggggg    93600

agacctccac atgtggaggg gaagtgaaac ctcataacca attctgttcc tgagattctc    93660

catcctttga atggaagaag agtggattag taattcactc tcaacctttt gctagcctta    93720

gtggaggaac gtggctctcc ccttaatatt ctggcccaag caaggtaaac actctttcct    93780

ttgttcccta atttcgcata gctgaggcaa ggctagaaca tttaaacaaa actttgaagt    93840

ggcagggatg ccaacagaga aatcagcaca aagcagagtc caagcagcac ctgcagatgg    93900

ctgcactcca ggacccatag gtcttggacc atcctagctc ctgaccagca tccaaatggc    93960

aggcaacatc tttgacaccc acatgcccag tggcacaagc cggatcatct tccctcttca    94020

aagtctagaa ccaagaaaga aatccaaggc aaaaggaaat tcccactccc aactaagacc    94080

cttcttccca ggcccagctt gcttttggcc agattattgg ccctggaatg tccaccttct    94140

ccccttagga gccccaaagg tcaagctggt cataccagca aagcactgac acaggatttc    94200

tgccccatca gtgcatgggt gccatttcat gacagagctt acctgggacc acataggagc    94260

ctcacacacc tcctctcacc tctgatgatg ctcaggctct aaatcttgtt tcttccatag    94320

gaaaagttaa ggattccaca agactgggaa attttattct ttaacattcc ctgctacaga    94380

aatcaataaa agcagctctc acatactcca ctttatagaa atataatagg ctctagagaa    94440

tatcacataa tcaatcaccc acttcatcgt ctctgagagc accaagggtt gcaaaggtat    94500

gatccctgac cgtgggctaa tccaagagca gctagcaagc tactccattc cctaaagtca    94560

gaatatccag ggcaaacttc acacccagcc acttaacgat gccgttgcct gctctgttta    94620

attagaagtc atgtgaccat gaatgggcct gtattttttc accattttca gtgatgaaat    94680

ggaagggatt agtggctcag caatccccct cctgccccag gaaagatgtg agccagcagt    94740

tctgccatga gcaaaggcca ctttggtctg attctttgct ctaacccaac aggatagcaa    94800

cccatcccca ccatgaagca gaaggcaagg atcagcctca tcacagcact tccccctctg    94860

cttgctgtgc agctcccgtg ggctccctgg aagggatcag acaggttctt ctcttcctcc    94920

ctcatagcca ctcatgcaga ggcttgcaca tcccatacat tcagtatgta cccttggtac    94980

agaattgaat ttagtcaaat aaagggtgac tttaaatttt catttgagct atggttaact    95040

cagagctgcc cattctgtct tccattcatt tacaaatttg cagagcatct gttgcagcca    95100

ggcactatgc agacaccagg gttagagcag tgagcaagac agacaaagtt cctactctta    95160

cagtttacag tccagtgaca gaggcaaaca gttggccaaa agttgcacat atatgttaat    95220

tcctggctgg ataaattgtc aagggagaaa aaatggggtg aagagcaaag gatgctcaag    95280

actgagcctc gaagaactct gatgtctaaa agttgggtaa aggagactat aaaagagcat    95340

cacaaatggc aagaaaagaa gcagaaatgt aaggcatggt ggagaccaag aaagcaacat    95400

ttcaaggtag aagggtacta ggcaatatca gacaagcgtc cttggatcta atattatggg    95460

aagtcattca tgatcttagt gagaacaatc tctgtcagga tagaggcaaa agctctgttg    95520

atgtgggctg aggagtgaat gagggacact gattgtacac aactctttca agaaattttg    95580

ctttgaaggt gggaagagat ctaagatggt agctggaggg agatgtaagt ttctgaaata    95640

ttctgcttta agttaggaga aactaggtca ttagagattt gtgcaataaa ccaagagaca    95700

aagagtaatg cacatggaca ttaatgttgc ctaggataat agccaagagt gggcaaatat    95760

ggccaagagc ctcacccatc attactgagg cagagggacc aagagtttgg caagcggcag    95820

taatgaagaa gtgacaaaac taggtggcaa agcttcaaag caagaagggg ttttacaaga    95880

cacaggaaga gcagtggtgt ggaagggtca gtggtgaaca aggagaacgc caggcctaac    95940

ccctgaggta catggggtag gggagaatgg cagcctttga atagggggag atatgtgcag    96000

atcaaggcag gtgagctcca tagaggtcag gagaagtttt gggagaaggt caaagcgtgg    96060

ggaatggggt tgggatcaag gactcacaga gcagtaagat gttcacagca ctaaaagaag    96120

agaagatcac agtaggagct ttttaaagac accataaaaa taaccagata taaatgatct    96180

cttggttatc caggccactc tgcctccttc caagatgcaa acaaccaaga cttgacccta    96240

cgccctatac ctgcatttgc ttaggcattt gcacagcacc aggaacagag ggaacatttc    96300

caagaataag tttccccttt gcacttgact ttactctcag caaagtagct caaattaata    96360

tttcaagcag ctcttgaact cttgcaatgt gcagggcact gcagggaaac aaagttaagg    96420

aaggtatagc ccttgtcctc aaacagctca ttgtctagta gagaagacgc atatacaaaa    96480

tgctagaact cgaggctgac tgaaaagtgg gatccccaaa gggacagggt agtgtgttgt    96540

cacgtgacta agggacactc catgcagtaa gtggagctta aaagagatgg attactcaag    96600

actgttggaa tttagacagc caagagagga gataggaggg cattgtgaat agaggcaagg    96660

gcacagacca ggacaaaaga agggcctggt ggcatcaaag ggccaggaga ggtattaagg    96720

acttgaactg gggcaatgag gtagagtcaa ctaaaagtga aattttggaa gaggtaagga    96780

tagtatttcg cttctgttaa gatgtggagt gtgatggaga caaaactcat ctacagataa    96840

cacagatgcc tggtttgtgc tggcccaaag gccctgatgc cactatctct tgttttctca    96900

gaacaagttc cagggttttg tctttgacat cgtgaccaga caagcttttg acatcaccat    96960

catggtcctc atctgcctca acatgatcac catgatggtg gagactgatg accaaagtga    97020

agaaaagacg aaaattctgg gcaaaatcaa ccagttcttt gtggccgtct tcacaggcga    97080

atgtgtcatg aagatgttcg ctttgaggca gtactacttc acaaatggct ggaatgtgtt    97140

tgacttcatt gtggtggttc tctccattgc gagtaagtgg gcagccacgt ggtggggaag    97200

ccccacctct gtttgggggt ctttgggatg ctcttctaaa accaaggaaa taaccaacca    97260

actttttgaa atacgtgttt atgttagaag aaccctgtat ttgcagcttt ccaagagtag    97320

caagttttaa atgccttggg ctgctctctc agtgaaatga agaggttctc ttggccttct    97380

ccatgctcac acgaagtgtt ttcaggcacc tactgtgtgc acagcccatg gctagaacct    97440

caggggctga cagggaataa tcactcctcc tgagaacctc agaccgtaag atgatggagt    97500

ctccagcaga ccttactttt atggtcttga aagcaggggg caggtggtgt aatgtgagat    97560

gagtcttaaa atctgttctg gaaaaggaga tggattgcca tcaaagtgag gaaagactgg    97620

gaggagattg ttcaaaggag attctcaagt ctagggtctg gaattaaatc tctacacaac    97680

tgttctatta gggaacatga gtgatagaaa agtcaagata tcaatgccaa gaaattaata    97740

ctgttaaggc ccagtctggg tgttgttgaa tgacaggccc agtattttgg gtccagtggt    97800

gttcagagaa aattactaga gttagaggct aacatgggga aatggagctg ccttgactga    97860

atacttccta agttctgagc actgagctgg gctccatgaa tgttcacagc agccctgtca    97920

agcaggtgtt attatcctta ttttatacat ttaaaattga gactcagaga tcaagaatat    97980

tatgcagggt cacagagttt ccaagggttg aagctgagtt tagaacaggc tccaatcttc    98040

taatgaactt gctgcctgtc accaacagcc aagagactgt ccctgggctt atgggttagc    98100

tgaagtttga ccctataaag gccaaatcat gctcaccagc ttcacctggc attataaatg    98160

tatcttgatt ggttatatcc tgacctgctt acttttcatg tcggggtgta gctgtagatt    98220

taatttgcca ctgatttagt aacaagagct gagagtatct aaatacaact taacagcatt    98280

tcatcaacct ccccaccttg gtgctgaaac acagccttgg gttgcgtgta tttccgggga    98340

tttcagtttg tttttgttct tgttttattt tgatattgct gctctgtttt ttaacacttt    98400

attgaggtat gatccacatg taaaaagcta tacatgttta atgtacacaa ctttatgagt    98460

ttggagataa gtatacaccc atgaaaccat caccaccatc aatgccagaa acatgtccat    98520

aacctccaaa tatttcctcc tgcctattta tttatttatt gggtgctagg aacacttaag    98580

atttattctc ttggcaaatt tttaggtaga caacacggta ttgctaacta tagggactat    98640

gctataagta gagctctagg atttattcat gtcacataac tggaagtttg tacactttga    98700

caagtacctc cccaatttcc cctcctccca gctcctggaa accaccattc tattctctgc    98760

tcccatgagt ttgactattt tagattcctt atataaatgc aatcatgtcg tttttgtcct    98820

tctgtgtctg gcttatctca cttagcataa taggagtttt tgttggttgg ttggttagtt    98880

gttttcattt ttgttttgtt ttgtttgtct tccaaaatga aagattccaa aggctatttt    98940

gattttatat taaagaaggg agcttgtttg tgtatcagta atatagaaat aaaacatagc    99000

caagtactta gttctatgat ggggatatct taactaccag ttcctgtggc ttacagggta    99060

gcaccatccg ctggggcagg aatcccttat agagctggaa aataagcaga aaaaacccac    99120

atatcaatct ttctaccctc tctccttacc tccctttctt ctttcccacc aacaagaggt    99180

gattgagtat ctaattgtta caagtacgag gaaccattct cccttaaaat aagatcctgg    99240

agcaaattaa aatgtgctgt agaccagttg tctggcagaa aattttacca gagtatgtag    99300

acaaataatg taccctacac gatgggaaca tgtcctagtt aaactggaaa ttcacagaag    99360

gtcttccaca aagattttat aatccaaaat tataattatt tcccaagtcc ccttctactt    99420

tcttcctctt tccaacacaa tattgtgacc catgtgcata acaacaaaga gcaagtaggg    99480

gagagggccc agggaacctg gcaaggagcg agagcttgct gctacatccc tcaccatttt    99540

tcctgtgaga tgttgaaccc tctcttacct aaaggccttg cctcatcttt ggtggaggcc    99600

tttggtacaa ataaggctcc ccaggtcccc aagaccaaaa atcaaacatc ttcaagttag    99660

acatcatata gagggacata tacattcttt atatttccaa ctttgttcat agttggagtt    99720

gggggcagta actgactccc ccaaaaaaac ctatctccag gccctaacat aaagttcaaa    99780

aacagctgga accgaaaaaa aaaaaaaaaa aacaaattaa ggcattgtgc agacagctgg    99840

tcattcaaat cccttatgct ttagctgtca gccagttgcc cgaatcctca ggcccccttg    99900

taattaacac caggctccgt acaattagcc acaggaccgg gtgccagaaa cagagtcaat    99960

cttcacagta ggaggtaggg agaggaatca taaggggtcc tggccttcac agagcacagg   100020

accagggtgg aggaaagggc atgacccaaa ggctgcagta tcagggagga gcagggtctg   100080

tgtcatagga aaaaacaggc caaagactgt gagcctgtgg aataaactgc agtcacttcc   100140

agctgaactt ggctgcagaa gataagtttt tgactgtgga ggttgaccaa gaggatattc   100200

taggcggagg caaagataac atggtaggaa gggtaagacg gaggaggaag agaggactta   100260

tgcaatgggc atttactgag cccctacttt gtgctaccta ccatgccagg ctctgagggc   100320

ccagagtcct caaatgtgga tgcccaagtg gcagtctata ccaagcaaag cagagtgtca   100380

tcacagccaa ctttgtcacg tctcatggct ggagatacta attagataat ttcttccttc   100440

ttttaaaggc ctgatttttt ctgcaattct taagtcactt caaagttact tctccccaac   100500

gctcttcaga gtcatccgcc tggcccgaat tggccgcatc ctcagactga tccgagcggc   100560

caaggggatc cgcacactgc tctttgccct catgatgtcc ctgcctgccc tcttcaacat   100620

cgggctgttg ctattccttg tcatgttcat ctactctatc ttcggtatgt ccagctttcc   100680

ccatgtgagg tgggaggctg gcatcgacga catgttcaac ttccagacct tcgccaacag   100740

catgctgtgc ctcttccaga ttaccacgtc ggccggctgg gatggcctcc tcagccccat   100800

cctcaacaca gggcccccct actgtgaccc caatctgccc aacagcaatg gcaccagagg   100860

ggactgtggg agcccagccg taggcatcat cttcttcacc acctacatca tcatctcctt   100920

cctcatcatg gtcaacatgt acattgcagt gattctggag aacttcaatg tggccacgga   100980

ggagagcact gagcccctga gtgaggacga ctttgacatg ttctatgaga cctgggagaa   101040

gtttgaccca gaggccactc agtttattac cttttctgct ctctcggact ttgcagacac   101100

tctctctggt cccctgagaa tcccaaaacc caatcgaaat atactgatcc agatggacct   101160

gcctttggtc cctggagata agatccactg cttggacatc ctttttgctt tcaccaagaa   101220

tgtcctagga gaatccgggg agttggattc tctgaaggca aatatggagg agaagtttat   101280

ggcaactaat ctttcaaaat catcctatga accaatagca accactctcc gatggaagca   101340

agaagacatt tcagccactg tcattcaaaa ggcctatcgg agctatgtgc tgcaccgctc   101400

catggcactc tctaacaccc catgtgtgcc cagagctgag gaggaggctg catcactccc   101460

agatgaaggt tttgttgcat tcacagcaaa tgaaaattgt gtactcccag acaaatctga   101520

aactgcttct gccacatcat tcccaccgtc ctatgagagt gtcactagag gccttagtga   101580

tagagtcaac atgaggacat ctagctcaat acaaaatgaa gatgaagcca ccagtatgga   101640

gctgattgcc cctgggccct agtgagaaca ctccagcctg gatatgttca gttatgatgc   101700

gtccttctgc tctgtgttaa ctctttccca ttgcagatca cacccagcta cagcctcacc   101760

aatgcatgcc actggtcaca atgtcagaac tgggcaggga atgcaactgg taaccacctt   101820

tgaaaaaacc atcatacaca aataggagtc agaagctaag agcacttcca ctgtgatttc   101880

ccttctgaat ttcaatatca gatcatgggt tctcttactc tccagaaaat atcccttgtc   101940

cttttatttt tgttgtaatc agattatatt tactgagaca aacttctcag gaccagaact   102000

tccaaagata tagaacaaga acattactga aggtccaagg tagtcctctg tggagcacca   102060

tacagagatt ggcaatatta tttaggattt tgcatgactg catgtgagag ctgtcggaca   102120

actgctctga cccagggtaa cacctgtggc ctatgtcatg aaaagccttt gagatatcca   102180

ttaaaattaa tatttttaaa tgtatgtcca caccagcgtt atatcataaa gcatcatttt   102240

atttttctct tatttctgtg atgctgacct gtatcatgag tcacttaccc ctcactttct   102300

gggatcctga tatttttcag tttgagattg aggctgggtg gagcaggaaa gagcactgtc   102360

ctgggatctg gaaatgccag ttggaatcct aacttttcca ccaattgtct ggctgaccag   102420

ggctaaagtc tttcccctct taacttcaat ttcctcactt gtaaaattgg tgggaaggga   102480

agaaaatgaa tgctttctat agacttcgca tctcgtgctg tagaactcca tggtgcctgc   102540

cccatttata tgggaaaagc actcttttct gaggctgaaa tggctggacc tttctgttgt   102600

gtagctaaag aggcagcttt tgaatacatt ccagagtctg ttcacatctc ataatcagac   102660

attaaggagg agagttttta cattacctgg cgtccagaac tccatagtta atataatcag   102720

aagaaaaagt ataatcatga gaatgatgat ccagtagata aaaggtatgg ccagtagttt   102780

ctttcattca tcctgcaaat gttattaatt acgtactata tgatgggcac tgctccaaga   102840

acaagagata aaataggaat taagccccca aaagattaat tgtatgaact gaatggagta   102900

agaattgtca gaggagttta tttaggccaa aggcatgttg cagattttga gatgaagaaa   102960

agcaaagact ccctataaca acataggaca tagggattgt aatgacagtc atgatcttcc   103020

attaactctt ggcccattcc cagccacaat cacaaagatt caaatatata gccaattcat   103080

tgtctatata tttgatcatt tcataagatt ttccatttgt ataattacaa agcacagtgg   103140

ctgatacatc tcacatgcct caagaataca gatttgccga ggccttgctc tcccttttct   103200

gtcactatta gcccataaga agtcaaagag gctctcaaga tgcttactgg gagttggcag   103260

catccacaga tgcaggttaa taagatgatg atgggatagc agaggtacca agccatctca   103320

aatcagctat tctctgaatg cctgatttat tctaaaagat gagttcaacc aaataactct   103380

tcctctctcg taccactgaa cccgggagca cagatactga ctgtgcagct tcttcaacgt   103440

ctaaatccca tgtggatgat gaaaaagcca tctgagatac tagcccaagt gtttataaga   103500

cagctaagtg gacagagagt ttgggcacag gtttattttt acaatgatat gtgaaagaat   103560

taagtgtgcc aaaccatcag actggttcta ttaaagcaga tgatactatt ctcaaaagta   103620

tttttacttt gagttgaatt atgctcccta aacataggaa cataattcaa ctttatgttg   103680

aattatgctt tgggttgaat aatgttccct aaaagggtat gttgaagttc taaccaatag   103740

tacctgtgat tgtgacctta tttgacatta aggtttttgc agatgtaaac aaattcagat   103800

gaaggtgagc cctaatccaa tgactggtgt tgctaaaata tgaggggaat ttgaacagag   103860

acacacagag aggagaatac catgggaaga tgcagaaaaa aacacacaca aagaaaagac   103920

agctgtatgg agacacagga agaaatcgga gagatacatg tgcaggccaa ggaatggcaa   103980

agattgctga agctaggagg agacatggaa ggcaacggtt ctcacctgcg ggcttcagag   104040

ggaacatggc tctgccaata ccttgatttt agacatctag cctcagaagt gtaagagaat   104100

aaatttctat tattgtcatc tacctagttt ctggtaattt gttacagcat cccagggaaa   104160

ctaatccatt tctcattttt tctgcacaaa tgcatttcct aaattgtaat gggaaacatt   104220

ggaaaaggga tgcaatatac acatcttgca tgacacggag tttttggaaa tgtatccaaa   104280

tgcaagatta tcttttgaaa atttcactag agccagtttc caagttcacc tggtggtaca   104340

attacaaggt agaaactaga tttccatggg agccaacctg agaaccagag ctaccttctc   104400

aaccccaccc acaagaggta aaactagaat ctctctggcc cagaatgtga ggatacctta   104460

gcactgaagg gagataagag acaggataat gatgctgact gtacaaatat ctggaacctg   104520

caagttctca aaagtatgcc tccaccataa acaccgccct aactttttat accattaaac   104580

tgcataacac atagacacag atggcaaata acattcagaa catccactta acacagaata   104640

gtaggtatcg gcagagccct ggtgtgctgg agcatttgct taagacaaaa gtgaagtcac   104700

tttcctaagt gttagggatg caagataaga cagatcttca gtctggagct gaacacaggc   104760

tgaaggttta caaataaatt aaaaagacaa ttcctttttt ttcttttttt aaaattatac   104820

tttaaattct agggtacatg tgcacaatgt acatgtttgt tatataggta tacatgtgcc   104880

atgttggttt gctgcaccca tcaacccgtc atctacatta ggtatttctc ctaatgctaa   104940

aaagtaaaaa aaagtaaagg tttttattat cattagactg tgtaacttaa gaatgaatga   105000

cttaattatt agggttgcca gtaacaaatc agaaatagag tatatcattt ccaaagtagg   105060

acaaggggga actatgctaa gaaacaatta gccaatcaaa aaagtaaggt taaaaaaaaa   105120

acaggattag gattgacttg gcaatgtggg ctcttttttg gttccgtatg aactttaaag   105180

tagttttttc caattctgag aagaaagtca ttggtagctt gatggggatg gcattgaatc   105240

tataaattac cttgggcagt atggccattt tcaagatatt gattcttcct acccatgagc   105300

atggagtatt cttccatttg tttgtatcct cttttatttc actgagcagt ggtttgtagt   105360

tctccttgaa gaggtccttc acatcccttg taagttgcat tcctaggtat tttattctct   105420

ttgaagcaat tgtgaatggg agttcactca tgatttggct ctctgtttgt ctgttattgg   105480

tgtataacaa agctggaggc atcacgctac ctgacttcaa actatattac aaggctacag   105540

taaccaaaac agcatggtac tggtaccaaa acagagatat agaccaatgg aacagaacag   105600

agccctcaga aataatgccg catatctaca actatctgat ctttgacaaa cctgacaaaa   105660

acaagaaatg gggaaaggat tccctattta ataaatggtg ctgggaaaac tggctagcca   105720

tatggagaaa gctgaaactg gatcccttcc ttacacctta tacaaaaatt aattcaagat   105780

ggattaaaga cttaaatgtt agacctaaaa ccataaaaac cctagaagag aacctaggca   105840

ataccattca ggacataggc atgggcaagg acttcatgtc taaaacacca aaagcaatgg   105900

caacaaaagt caaaattgac aaatgggatc tcattaaact aaagagcttc tgagcagcaa   105960

aagaaaccac catcagagtg aacagaaacc tacaggatgg gagaaaattt ttgcaaccta   106020

ctcatctgac gaagggctaa tatccagaat ctacaatgaa ctcaaacaaa tttacaagga   106080

aaaaaatccc atcaaaaagt gggcgaagga tatgaacaga cacttctcaa aagaagacat   106140

ttatgcagcc aaaaaacaca tgaaaaaatg ctcatcatca ctggccatca gagaaatgca   106200

aatcaaaacc acaatgagat accatctcac accagttaga atggcgatca ttaaaaagtc   106260

aggaaacaac aggtgctgga gaggatgtgg agaaatagga acacttttac actgttggtg   106320

ggtctgtaaa ctagttcaat cattgtggaa gtcggtgtgg caattcctca gggatctaga   106380

accagaaata ccatttgacc cagccatccc attactgggt atatacccaa aggattataa   106440

atcatactgc tataaagaca catgcacacg tatgtttatt gtggcactat tcacaatagc   106500

aaagacttgg aaccaaccca aatgtccaac agtgatagac tggattaaga aaatgtggca   106560

catatacacc atggaatact atgcagccat aaaaaatgat gagttcatgt cctttgcagg   106620

gacatggatg aagctggaaa ccatcattct cagcaaacta tcgcaaggac aaaaaaaacc   106680

aaacaccgca tgttctcact cataggtggg aattgaacaa taagaacaca tggacacagg   106740

aaggggaaca tcacacaccg gggacagttg tggggtggag ggagggggga gggatagcat   106800

taggagatat acctaatgta aatgacaagt taatgggtgc agcacaccaa catggcacat   106860

gtatacatat gtaacaaacc tgcacgttgt gctcatgtat cctaaaactt aaagtataat   106920

aataattaaa aaaacccggg atatagagac atacagaata aaagaaacaa atagaaaaga   106980

cagagtaaag tagtatattc aaaaacaaaa atattcataa attacattaa atttaaatgg   107040

actctgggaa aaagagtgtc agtcaagatt tttaaaaatt caaataaatt ctgtttacag   107100

aaagccacac aaaacctaag gttaccaaaa gggtacaaat acaagtacat agggcacatt   107160

tacaaaaata gtccgtatgc ctggccatag aataaaattc aaacaatgt               107209


<210> 5305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5305
tctgtttaca gaaagccaca                                                   20


<210> 5306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5306
cagagtaaag tagtatattc                                                   20


<210> 5307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5307
taaagtataa taataattaa                                                   20


<210> 5308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5308
cacgttgtgc tcatgtatcc                                                   20


<210> 5309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5309
caaactatcg caaggacaaa                                                   20


<210> 5310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5310
gccatcagag aaatgcaaat                                                   20


<210> 5311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5311
agaagacatt tatgcagcca                                                   20


<210> 5312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5312
atgggcaagg acttcatgtc                                                   20


<210> 5313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5313
aatgttagac ctaaaaccat                                                   20


<210> 5314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5314
aaagacttaa atgttagacc                                                   20


<210> 5315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5315
tatttaataa atggtgctgg                                                   20


<210> 5316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5316
tgatctttga caaacctgac                                                   20


<210> 5317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5317
aaacagcatg gtactggtac                                                   20


<210> 5318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5318
tattacaagg ctacagtaac                                                   20


<210> 5319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5319
caaaaaagta aggttaaaaa                                                   20


<210> 5320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5320
tcaaccccac ccacaagagg                                                   20


<210> 5321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5321
taccatggga agatgcagaa                                                   20


<210> 5322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5322
caactggtaa ccacctttga                                                   20


<210> 5323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5323
ctctggtccc ctgagaatcc                                                   20


<210> 5324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5324
gcagggtctg tgtcatagga                                                   20


<210> 5325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5325
ggaaccgaaa aaaaaaaaaa                                                   20


<210> 5326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5326
caggccctaa cataaagttc                                                   20


<210> 5327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5327
gcagtaactg actcccccaa                                                   20


<210> 5328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5328
agagctggaa aataagcaga                                                   20


<210> 5329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5329
gtgtatcagt aatatagaaa                                                   20


<210> 5330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5330
gggtctttgg gatgctcttc                                                   20


<210> 5331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5331
gatgtggagt gtgatggaga                                                   20


<210> 5332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5332
cggcagtaat gaagaagtga                                                   20


<210> 5333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5333
gcaaggctag aacatttaaa                                                   20


<210> 5334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5334
tgctagggac aacccttggc                                                   20


<210> 5335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5335
aactttgtca gaacaaagtg                                                   20


<210> 5336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5336
cagtcttctg ccagaagata                                                   20


<210> 5337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5337
aatacccaat cctaagggag                                                   20


<210> 5338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5338
aatccaaagg gcccctaaag                                                   20


<210> 5339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5339
ttctctcatt ttacagatga                                                   20


<210> 5340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5340
tagaatctca ggaactatca                                                   20


<210> 5341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5341
aaacagacta ataggtgaat                                                   20


<210> 5342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5342
gggattatca ggtggtgagt                                                   20


<210> 5343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5343
acaagtctga ctgcaagatt                                                   20


<210> 5344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5344
gaagtagtca tcatagcttc                                                   20


<210> 5345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5345
tccgcctcaa aaaacaaaca                                                   20


<210> 5346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5346
cagagcgaga ctccgcctca                                                   20


<210> 5347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5347
atcacctgag gttaggagtt                                                   20


<210> 5348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5348
catgcgggta agtctgatct                                                   20


<210> 5349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5349
ttttaataaa agggaagaga                                                   20


<210> 5350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5350
tctttggacc accacttaaa                                                   20


<210> 5351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5351
actcagcgag caaaaatact                                                   20


<210> 5352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5352
ctccaccagt ctgataaaag                                                   20


<210> 5353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5353
gagatcgaga ccatcccggc                                                   20


<210> 5354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5354
atatacacat attacaaaaa                                                   20


<210> 5355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5355
actcaaagag aaactcactt                                                   20


<210> 5356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5356
caggatctga gaggtgggag                                                   20


<210> 5357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5357
agattgtcca ggaagggtga                                                   20


<210> 5358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5358
tcatgtgtca tttactctct                                                   20


<210> 5359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5359
gtcacccaac ttgtcagtag                                                   20


<210> 5360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5360
gtaagaagga tatggctagg                                                   20


<210> 5361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5361
tcaccaccat aaacaccact                                                   20


<210> 5362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5362
gggccttcct ctttaccctc                                                   20


<210> 5363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5363
taattaatgg agcccaagga                                                   20


<210> 5364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5364
gcgctaacat atttagtcat                                                   20


<210> 5365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5365
ccccaatctg agggggctca                                                   20


<210> 5366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5366
ttggcaagca gctcctaggg                                                   20


<210> 5367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5367
aaggtaatga gcacagctac                                                   20


<210> 5368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5368
ccagatcttt ggtttccagg                                                   20


<210> 5369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5369
gtctccaaaa gcagtgtcca                                                   20


<210> 5370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5370
agaaccatac aaatatattt                                                   20


<210> 5371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5371
ctttacctat ctgctatcct                                                   20


<210> 5372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5372
actatttgca agcaaaactg                                                   20


<210> 5373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5373
tgaccccaac tatttgcaag                                                   20


<210> 5374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5374
tttcacaata caattacttc                                                   20


<210> 5375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5375
cctattatac agacaatctc                                                   20


<210> 5376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5376
tccagcctgg gcaacaaggg                                                   20


<210> 5377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5377
gagcgagact ccgtctcatt                                                   20


<210> 5378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5378
gaccagcctg gccaacagga                                                   20


<210> 5379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5379
gttacatacc cacatacaca                                                   20


<210> 5380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5380
gtcctgctat cccatgaggc                                                   20


<210> 5381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5381
aggacagttt tcagttttca                                                   20


<210> 5382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5382
ctttgcgttt ttgtgtttgc                                                   20


<210> 5383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5383
accaatatta ttatgccctt                                                   20


<210> 5384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5384
aaaaaaaaaa aaaaaaaaaa                                                   20


<210> 5385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5385
tggctactaa tccagttttt                                                   20


<210> 5386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5386
ctagacttga agagaggtga                                                   20


<210> 5387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5387
gcatagcact ggacacttga                                                   20


<210> 5388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5388
cagataacat agcaactgaa                                                   20


<210> 5389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5389
tcccaccacc attcacgtgg                                                   20


<210> 5390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5390
aggcagctag ttgcccttta                                                   20


<210> 5391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5391
gctgtagaag gttaagtgta                                                   20


<210> 5392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5392
caggaaagga aaagggagac                                                   20


<210> 5393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5393
tttttagggc tatgagattc                                                   20


<210> 5394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5394
tttcaagtgc atatagtaaa                                                   20


<210> 5395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5395
acatttttaa attatcagga                                                   20


<210> 5396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5396
gaagaaaatt gaaaaaaaaa                                                   20


<210> 5397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5397
cataatgtgc acatttaccc                                                   20


<210> 5398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5398
tgaaactaca aaagaaagaa                                                   20


<210> 5399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5399
agaaatggac atgtgtatat                                                   20


<210> 5400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5400
tctaaaatcc agtcagtgat                                                   20


<210> 5401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5401
tgtttttttc atttattctc                                                   20


<210> 5402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5402
tcctccaggt ttgagcccta                                                   20


<210> 5403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5403
aaaaaatgtt tgagggattt                                                   20


<210> 5404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5404
catctgcttt gcatgcatca                                                   20


<210> 5405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5405
ttttagatgc ataatttttc                                                   20


<210> 5406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5406
tccagggcaa atggaatcac                                                   20


<210> 5407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5407
tcttgttgga caggtatgag                                                   20


<210> 5408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5408
ttttctaggc ctcgcctctg                                                   20


<210> 5409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5409
agacattgcc caccatttgt                                                   20


<210> 5410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5410
tcaggagaaa gcgaatgaag                                                   20


<210> 5411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5411
cctgatggtt atatctgcct                                                   20


<210> 5412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5412
ttgaactctg atctctgaca                                                   20


<210> 5413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5413
tcacaaggaa tgcaggtaaa                                                   20


<210> 5414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5414
tttcagcagc ttccaaggtt                                                   20


<210> 5415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5415
caccttcatc agctcactag                                                   20


<210> 5416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5416
cataaagatg ctaccctgtg                                                   20


<210> 5417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5417
ttaccctcac aagtagagga                                                   20


<210> 5418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5418
tctcatggca gtgttcccag                                                   20


<210> 5419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5419
gaccccaaaa ttttgtgaat                                                   20


<210> 5420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5420
aaccaactac tcatctcaca                                                   20


<210> 5421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5421
ttcagagttc ttagagcatt                                                   20


<210> 5422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5422
ccaaaaacca cctgttccct                                                   20


<210> 5423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5423
aagaacttat tcatgtaacc                                                   20


<210> 5424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5424
acccaacacc acctgtttcc                                                   20


<210> 5425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5425
aaactagtac aaccactaag                                                   20


<210> 5426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5426
attatcaggg aaatgcaaat                                                   20


<210> 5427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5427
aaacacaaat aaatcagcaa                                                   20


<210> 5428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5428
ggacccaaag caaatccaac                                                   20


<210> 5429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5429
cttctagaca ttggcttagg                                                   20


<210> 5430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5430
attctagaag ataacattgg                                                   20


<210> 5431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5431
tgatctttga aaaagcaaac                                                   20


<210> 5432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5432
ggctatagta tagcctgtac                                                   20


<210> 5433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5433
gatttctaca aggaaaacta                                                   20


<210> 5434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5434
aggtgaaaga tttctacaag                                                   20


<210> 5435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5435
tgcaaaaaaa aaacaaaaat                                                   20


<210> 5436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5436
ttttacaaca gctgcaaaaa                                                   20


<210> 5437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5437
tcagtaaagt ttcaggatac                                                   20


<210> 5438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5438
atccagcatc ccattatgat                                                   20


<210> 5439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5439
cacgtcacat aaacagaatt                                                   20


<210> 5440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5440
agccagtatc accctaatac                                                   20


<210> 5441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5441
aggaattaga gaaacaagaa                                                   20


<210> 5442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5442
ataatagtca cacaacttat                                                   20


<210> 5443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5443
tcaaaactat acaaatacat                                                   20


<210> 5444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5444
ttaactccaa aagaaaccct                                                   20


<210> 5445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5445
atggacttaa cagatattta                                                   20


<210> 5446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5446
cactggagct cccaaattta                                                   20


<210> 5447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5447
gtagctattc ttatatcaga                                                   20


<210> 5448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5448
cataaatatc aaaggaccta                                                   20


<210> 5449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5449
aggaattcta aatcttgaaa                                                   20


<210> 5450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5450
tatttgaggg aataattgag                                                   20


<210> 5451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5451
aatagaaatc taaaagtttg                                                   20


<210> 5452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5452
cagagaaata gatataaaga                                                   20


<210> 5453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5453
aaccaactta aagaaatttt                                                   20


<210> 5454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5454
aggagacacc agagaaagat                                                   20


<210> 5455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5455
aactttgatc ccaggaaaaa                                                   20


<210> 5456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5456
cctgccttgg tagctgaaca                                                   20


<210> 5457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5457
gaaattctgc aagacaggtg                                                   20


<210> 5458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5458
cagtctgcac tccagtttct                                                   20


<210> 5459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5459
aagctcaact ggttcctgta                                                   20


<210> 5460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5460
tccacttcct gtgagatttc                                                   20


<210> 5461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5461
attggcttcc tattatgaga                                                   20


<210> 5462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5462
tttataaaga ttctgacaaa                                                   20


<210> 5463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5463
agttaagatt ttctaattta                                                   20


<210> 5464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5464
gtatattatg catattttac                                                   20


<210> 5465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5465
cattttattt tatagttgaa                                                   20


<210> 5466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5466
gtggttggag aagaaacaag                                                   20


<210> 5467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5467
gcactcctgc tggtaagata                                                   20


<210> 5468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5468
gttaaaggtt gagaagacaa                                                   20


<210> 5469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5469
aagtaatgat ataaagctat                                                   20


<210> 5470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5470
aatggatgtg gataatctcc                                                   20


<210> 5471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5471
aaaaacagtg tatgtgcttc                                                   20


<210> 5472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5472
ttctaacttt ttatgttttc                                                   20


<210> 5473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5473
ctaagcataa caatattctg                                                   20


<210> 5474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5474
agcaataaat tacaaaatag                                                   20


<210> 5475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5475
gaaattattt aaagacctaa                                                   20


<210> 5476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5476
tttcgaggga aggaaagata                                                   20


<210> 5477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5477
cagaaagtgg aaataatata                                                   20


<210> 5478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5478
accaaatatt aagccatgac                                                   20


<210> 5479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5479
gaaaatgcac ctccttttca                                                   20


<210> 5480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5480
attagagtag gaggataaat                                                   20


<210> 5481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5481
ttgtaccaac ctaatatttt                                                   20


<210> 5482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5482
acggcaaatt tcaacaatgc                                                   20


<210> 5483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5483
caaggttctc atctcctttg                                                   20


<210> 5484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5484
ggtgaatatg gtggatgagg                                                   20


<210> 5485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5485
aaatacagtc agataatgga                                                   20


<210> 5486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5486
acacagagga caaatgatgt                                                   20


<210> 5487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5487
gaacaaagag aaagagaatg                                                   20


<210> 5488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5488
cttcttttgg agttttaatg                                                   20


<210> 5489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5489
tgcatgttac atatcataat                                                   20


<210> 5490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5490
atataaagtt tgaaatcaag                                                   20


<210> 5491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5491
tctgttatat tctaaaatga                                                   20


<210> 5492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5492
gtttatgaac atttgcccat                                                   20


<210> 5493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5493
gaagcactaa ctatacagga                                                   20


<210> 5494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5494
ctttatgacc tcagactaag                                                   20


<210> 5495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5495
ggataagctt tttgaaagga                                                   20


<210> 5496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5496
agaattagga atctcactgg                                                   20


<210> 5497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5497
tattgtgtaa agtttttaaa                                                   20


<210> 5498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5498
cctttgagat caaaagaaaa                                                   20


<210> 5499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5499
agcaaactaa cacaagaaca                                                   20


<210> 5500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5500
tcagaatctg ggagttttcc                                                   20


<210> 5501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5501
ctatgaaaga gagacaggag                                                   20


<210> 5502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5502
gacacatcaa ggcatttaca                                                   20


<210> 5503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5503
gatgtgttcc taagtaactg                                                   20


<210> 5504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5504
gttaacatca caaattactc                                                   20


<210> 5505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5505
agcacctccc agagggcaag                                                   20


<210> 5506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5506
acctgtggat gcacaacttg                                                   20


<210> 5507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5507
agataatgcc tctcatgttt                                                   20


<210> 5508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5508
tggagacaga agaaacatta                                                   20


<210> 5509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5509
ttttagtggg tttataaaat                                                   20


<210> 5510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5510
cttggaaccc ctggtgtccc                                                   20


<210> 5511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5511
aaaaagaaaa agaaaaagaa                                                   20


<210> 5512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5512
tgcctacaaa aaaatttttt                                                   20


<210> 5513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5513
tattttaagg aggaaattgt                                                   20


<210> 5514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5514
aggagaagag agaaagttag                                                   20


<210> 5515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5515
gttactattg ttattattct                                                   20


<210> 5516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5516
caaattccca ccccaatgtt                                                   20


<210> 5517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5517
taagggacag gactggtaga                                                   20


<210> 5518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5518
acttaaggga atatacctgc                                                   20


<210> 5519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5519
gaccagcctg gggaacatgg                                                   20


<210> 5520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5520
actttcttct cagaattgga                                                   20


<210> 5521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5521
ttacacagtc taatgataat                                                   20


<210> 5522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5522
ttgcatttgg atacatttcc                                                   20


<210> 5523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5523
ctgaatttgt ttacatctgc                                                   20


<210> 5524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5524
ttctggacgc caggtaatgt                                                   20


<210> 5525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5525
ttcatttgct gtgaatgcaa                                                   20


<210> 5526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5526
cttggtcaac ctccacagtc                                                   20


<210> 5527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5527
ctttcatttt ggaagacaaa                                                   20


<210> 5528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5528
attttggaag acaaacaaaa                                                   20


<210> 5529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5529
aaacaaaaca aaacaaaaat                                                   20


<210> 5530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5530
caactaacca accaaccaac                                                   20


<210> 5531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5531
taagccagac acagaaggac                                                   20


<210> 5532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5532
catacctcaa taaagtgtta                                                   20


<210> 5533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5533
acagagcagc aatatcaaaa                                                   20


<210> 5534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5534
tatcaaaata aaacaagaac                                                   20


<210> 5535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5535
tgtgcacaca gtaggtgcct                                                   20


<210> 5536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5536
agagagcagc ccaaggcatt                                                   20


<210> 5537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5537
tctggtcacg atgtcaaaga                                                   20


<210> 5538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5538
aaccctggaa cttgttctga                                                   20


<210> 5539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5539
cccacgcttt gaccttctcc                                                   20


<210> 5540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5540
actgctcttc ctgtgtcttg                                                   20


<210> 5541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5541
agtatgtggg ggaaggtgcc                                                   20


<210> 5542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5542
ccaatcctgt acttgaactc                                                   20


<210> 5543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5543
tagccccatt gaatgaatga                                                   20


<210> 5544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5544
agtatttatc ctcagactcc                                                   20


<210> 5545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5545
ttcctcaaca gtgaacagag                                                   20


<210> 5546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5546
caatcgacaa aggtacaagg                                                   20


<210> 5547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5547
cggtatagtt gatgcacctc                                                   20


<210> 5548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5548
ttctccttaa ataccataca                                                   20


<210> 5549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5549
tgccgtggtc aagaaccagt                                                   20


<210> 5550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5550
ccaatgatag tggagcaaag                                                   20


<210> 5551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5551
cataaagggg gaagggttac                                                   20


<210> 5552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5552
tcttaaacaa tctgggcaag                                                   20


<210> 5553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5553
cagactcctc actaaatgct                                                   20


<210> 5554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5554
tgctgaatgc aagggagaaa                                                   20


<210> 5555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5555
tacaagtgac tggcaggagt                                                   20


<210> 5556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5556
acatgaggcg caagatgagt                                                   20


<210> 5557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5557
cttctgccca cctatacctg                                                   20


<210> 5558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5558
cagcccagcc cagggtcaaa                                                   20


<210> 5559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5559
ggtcaaataa aactattaat                                                   20


<210> 5560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5560
ctagccgggg tcatggacaa                                                   20


<210> 5561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5561
ggggtcatgg acaagaaaac                                                   20


<210> 5562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5562
tggacaagaa aacaaaaaca                                                   20


<210> 5563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5563
acacccagaa gttgtgtact                                                   20


<210> 5564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5564
agtgggggag aatcacaagg                                                   20


<210> 5565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5565
actaaatatg ttagcgcttg                                                   20


<210> 5566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5566
gtttagcttt cttctgtcta                                                   20


<210> 5567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5567
ctggaaacca aagatctggg                                                   20


<210> 5568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5568
ctgcattcga taggtattgg                                                   20


<210> 5569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5569
ctcatatggg aagcagagct                                                   20


<210> 5570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5570
ggcagctgat aaacacaaat                                                   20


<210> 5571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5571
ttgtttaaga gttgcagtaa                                                   20


<210> 5572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5572
gttgcagtaa aaaaacaaac                                                   20


<210> 5573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5573
aaactatgtg cagagaataa                                                   20


<210> 5574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5574
tccagaattg aagaaaatta                                                   20


<210> 5575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5575
ctccccttgt gtgatgatga                                                   20


<210> 5576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5576
gcctttcact gtttaaacct                                                   20


<210> 5577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5577
taatcttgga accttgatac                                                   20


<210> 5578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5578
tgtgattatg ttagaaaatt                                                   20


<210> 5579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5579
gatcctatgg agaaaattat                                                   20


<210> 5580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5580
ttacagcagt ccctaatggg                                                   20


<210> 5581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5581
cttgtgctag gcccttggga                                                   20


<210> 5582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5582
agtattccag gcacagcgaa                                                   20


<210> 5583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5583
tcaatctgct ccagttttct                                                   20


<210> 5584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5584
gctccagttt tctgaaaact                                                   20


<210> 5585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5585
tgaaaataaa gtctattaat                                                   20


<210> 5586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5586
ggtgaggttt tggcaaacac                                                   20


<210> 5587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5587
caaaagtagc acatagacct                                                   20


<210> 5588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5588
cccagcctcg tattttatta                                                   20


<210> 5589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5589
ttggtcttta gagtgttttt                                                   20


<210> 5590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5590
cacccacccc tgaggatctt                                                   20


<210> 5591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5591
tttccccaag ccatcaagag                                                   20


<210> 5592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5592
agtcagtctg gttcagtagt                                                   20


<210> 5593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5593
tgcatccttc ttatggagaa                                                   20


<210> 5594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5594
gacctcagcc taggtgctgc                                                   20


<210> 5595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5595
ccttcattgt acttgcctgg                                                   20


<210> 5596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5596
ttttgaatct catagcccta                                                   20


<210> 5597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5597
cattgtttat aataataatg                                                   20


<210> 5598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5598
gtagtttcac ttttttcact                                                   20


<210> 5599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5599
aaagtatcta cttgccagct                                                   20


<210> 5600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5600
cattagcatg caaatatgct                                                   20


<210> 5601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5601
ctcaaaacaa acaaacaaac                                                   20


<210> 5602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5602
acaaaaactc ccccaaacac                                                   20


<210> 5603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5603
gatgatgtgc cctatgctca                                                   20


<210> 5604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5604
tcctctcctc agattttctt                                                   20


<210> 5605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5605
aatggaggtc aggctgtgag                                                   20


<210> 5606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5606
cctgactcat ttaatcctca                                                   20


<210> 5607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5607
agttttcgag aataaatgaa                                                   20


<210> 5608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5608
tgctgtttga tgactaatag                                                   20


<210> 5609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5609
ttgatgacta atagcaaaac                                                   20


<210> 5610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5610
actaatagca aaacaaaaac                                                   20


<210> 5611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5611
aaaaaccaaa acaaacaaac                                                   20


<210> 5612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5612
gcctttcccc agattttctt                                                   20


<210> 5613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5613
aatggagatc cagctgtgag                                                   20


<210> 5614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5614
attcagccta gggctgggag                                                   20


<210> 5615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5615
tttgaaaaat tatgcatcta                                                   20


<210> 5616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5616
ctagccagag agggcaaatg                                                   20


<210> 5617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5617
actggtctgt gattttccac                                                   20


<210> 5618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5618
gttataaaat ggctttagat                                                   20


<210> 5619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5619
gatgtttctt ccctgattct                                                   20


<210> 5620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5620
attgtgaagt gtcaattaaa                                                   20


<210> 5621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5621
aaaaaactaa gtaaaaaaat                                                   20


<210> 5622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5622
tcacttagct tcttctttga                                                   20


<210> 5623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5623
gtattggttt ctgttatcca                                                   20


<210> 5624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5624
cagtagcaat aacgcagact                                                   20


<210> 5625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5625
tcagaaagaa gtcagttgcc                                                   20


<210> 5626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5626
catttaagtc aaaggcaaat                                                   20


<210> 5627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5627
ggaaatagaa tacccaaaag                                                   20


<210> 5628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5628
agttgcagcc ccaccaaggc                                                   20


<210> 5629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5629
gtggagtgtg aggaaggtgg                                                   20


<210> 5630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5630
tgggaaaacc agggaggagg                                                   20


<210> 5631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5631
agagaaggga gttaggctgt                                                   20


<210> 5632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5632
tcaccatttg tttgtctgaa                                                   20


<210> 5633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5633
ctgctctgac tgctccaaga                                                   20


<210> 5634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5634
aagaagctgg aggctcatct                                                   20


<210> 5635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5635
agagcagacc taagaaagct                                                   20


<210> 5636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5636
cagaagaaga gttagagaaa                                                   20


<210> 5637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5637
acagagcaag acttcgtctc                                                   20


<210> 5638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5638
acagcaacaa caacaacaac                                                   20


<210> 5639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5639
acaacaacaa caacaaaaac                                                   20


<210> 5640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5640
aaaaacaaaa acaaaaaaaa                                                   20


<210> 5641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5641
caaagacaaa atggaatttt                                                   20


<210> 5642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5642
caaaaatatg atagcaaaag                                                   20


<210> 5643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5643
tgaagaagaa aaaatctcta                                                   20


<210> 5644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5644
acagctgtgc atcaggccta                                                   20


<210> 5645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5645
gaacaaatta gggataaata                                                   20


<210> 5646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5646
ttattaactc caaggaaagc                                                   20


<210> 5647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5647
tttttttgtc agaatcttta                                                   20


<210> 5648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5648
aatcccgata ttcaggctct                                                   20


<210> 5649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5649
tattcataaa aatggtaatt                                                   20


<210> 5650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5650
aacatttcat tccttatttt                                                   20


<210> 5651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5651
atcagaatct cattcatttt                                                   20


<210> 5652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5652
gctttatatc attacttgac                                                   20


<210> 5653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5653
atcattattg ttatgcttca                                                   20


<210> 5654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5654
gaagcacata cactgttttt                                                   20


<210> 5655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5655
aaatacctaa atgtagaaag                                                   20


<210> 5656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5656
gaaaactgta actttgagga                                                   20


<210> 5657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5657
tatccatttg ggcaaatccc                                                   20


<210> 5658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5658
aaatcccaaa aacataattt                                                   20


<210> 5659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5659
acatgttctt tgccaggtga                                                   20


<210> 5660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5660
atctgttcag ctaatttcta                                                   20


<210> 5661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5661
agaagctcca aagcacttcc                                                   20


<210> 5662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5662
gcaaatcgat gagatgcaca                                                   20


<210> 5663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5663
tagtggttgt ctttataagt                                                   20


<210> 5664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5664
tataaattta taattataat                                                   20


<210> 5665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5665
ggcattttga gagggtgggg                                                   20


<210> 5666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5666
tgcaaaaaaa tgttttacat                                                   20


<210> 5667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5667
atgcataata aaaatgtaca                                                   20


<210> 5668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5668
aaaacataaa ttaattattt                                                   20


<210> 5669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5669
acacaaacag aaccaatgac                                                   20


<210> 5670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5670
caatatcata ctgaatgggc                                                   20


<210> 5671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5671
aaactggaag catttccttt                                                   20


<210> 5672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5672
atgacatgac tgtatattta                                                   20


<210> 5673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5673
gagaggacac aaataaatgg                                                   20


<210> 5674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5674
tactacaaag ctacagtaac                                                   20


<210> 5675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5675
aaacagcgag gtactggtac                                                   20


<210> 5676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5676
tatttaataa atggtgtggg                                                   20


<210> 5677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5677
aaagacttaa acataagacc                                                   20


<210> 5678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5678
aacataagac ctaaaaccat                                                   20


<210> 5679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5679
aaaccataaa aaccctagaa                                                   20


<210> 5680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5680
gctaatatcc agaatctaca                                                   20


<210> 5681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5681
acttaaacaa atttacaaga                                                   20


<210> 5682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5682
gtcattagag aaatgccagt                                                   20


<210> 5683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5683
agcaaactga cataagaaca                                                   20


<210> 5684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5684
ccactgattt ggttttcttt                                                   20


<210> 5685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5685
ccagtgtaaa tggtattttt                                                   20


<210> 5686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5686
aagtatgacg cttgatactt                                                   20


<210> 5687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5687
gtggatatgg aatgtttttg                                                   20


<210> 5688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5688
atgaaatact ggctcaggaa                                                   20


<210> 5689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5689
cagtgcttcc taaggaaaaa                                                   20


<210> 5690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5690
ttatgtataa tattagttat                                                   20


<210> 5691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5691
aaaattcaag attcagctca                                                   20


<210> 5692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5692
aagaaaaaaa tgtaaaaaga                                                   20


<210> 5693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5693
aagcagcttc tgacattacc                                                   20


<210> 5694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5694
agcaccataa atgtctgaaa                                                   20


<210> 5695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5695
cataaatgtc tgaaacaaaa                                                   20


<210> 5696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: CAAAAC

<400> 5696
tatatctcat attagaaatt                                                   20


<210> 5697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5697
attcaaaact caggaaattt                                                   20


<210> 5698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: TAAAAC

<400> 5698
ttttcatttt ataaacccac                                                   20


<210> 5699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5699
atatttccta gttcatggag                                                   20


<210> 5700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5700
cttaactttc ctccaacttt                                                   20


<210> 5701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: AAAAAC

<400> 5701
atggcgaaac ttaatagctg                                                   20


<210> 5702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NAAAAC;
      PAM sequence: GAAAAC

<400> 5702
gtctttacat gacattctga                                                   20


<210> 5703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 5703
aatagtccgt atgcctggcc                                                   20


<210> 5704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 5704
aattcaaata aattctgttt                                                   20


<210> 5705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 5705
atacagaata aaagaaacaa                                                   20


<210> 5706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5706
atatagagac atacagaata                                                   20


<210> 5707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 5707
aacccgggat atagagacat                                                   20


<210> 5708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 5708
ccaacagtga tagactggat                                                   20


<210> 5709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 5709
aattcctcag ggatctagaa                                                   20


<210> 5710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 5710
acaggtgctg gagaggatgt                                                   20


<210> 5711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 5711
gagataccat ctcacaccag                                                   20


<210> 5712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 5712
gctcatcatc actggccatc                                                   20


<210> 5713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAT

<400> 5713
atctgacgaa gggctaatat                                                   20


<210> 5714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 5714
gaacagaaac ctacaggatg                                                   20


<210> 5715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 5715
agaaaccacc atcagagtga                                                   20


<210> 5716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5716
taaagagctt ctgagcagca                                                   20


<210> 5717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 5717
ggaaaactgg ctagccatat                                                   20


<210> 5718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 5718
tttgacaaac ctgacaaaaa                                                   20


<210> 5719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 5719
aatggaacag aacagagccc                                                   20


<210> 5720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5720
gtagtttttt ccaattctga                                                   20


<210> 5721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 5721
aggacaaggg ggaactatgc                                                   20


<210> 5722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 5722
ttagggttgc cagtaacaaa                                                   20


<210> 5723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAT

<400> 5723
tatcattaga ctgtgtaact                                                   20


<210> 5724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 5724
attcagaaca tccacttaac                                                   20


<210> 5725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAT

<400> 5725
aaaactagaa tctctctggc                                                   20


<210> 5726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAT

<400> 5726
cccacccaca agaggtaaaa                                                   20


<210> 5727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAA

<400> 5727
cctggtggta caattacaag                                                   20


<210> 5728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 5728
catctagcct cagaagtgta                                                   20


<210> 5729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5729
acagctgtat ggagacacag                                                   20


<210> 5730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5730
atgcagaaaa aaacacacac                                                   20


<210> 5731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 5731
ggagaatacc atgggaagat                                                   20


<210> 5732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 5732
tgaacagaga cacacagaga                                                   20


<210> 5733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 5733
tatttttaca atgatatgtg                                                   20


<210> 5734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 5734
ctgatacatc tcacatgcct                                                   20


<210> 5735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5735
catgttgcag attttgagat                                                   20


<210> 5736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAT

<400> 5736
attgtatgaa ctgaatggag                                                   20


<210> 5737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 5737
cagaagaaaa agtataatca                                                   20


<210> 5738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5738
ctccatagtt aatataatca                                                   20


<210> 5739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5739
ttgtaaaatt ggtgggaagg                                                   20


<210> 5740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 5740
atcatgggtt ctcttactct                                                   20


<210> 5741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 5741
ctttcaccaa gaatgtccta                                                   20


<210> 5742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 5742
gacatccttt ttgctttcac                                                   20


<210> 5743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 5743
agacactctc tctggtcccc                                                   20


<210> 5744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 5744
attagccaca ggaccgggtg                                                   20


<210> 5745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 5745
tgctgtagac cagttgtctg                                                   20


<210> 5746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 5746
cttatagagc tggaaaataa                                                   20


<210> 5747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 5747
cttgtttgtg tatcagtaat                                                   20


<210> 5748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 5748
aaccatcacc accatcaatg                                                   20


<210> 5749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 5749
taaaattgag actcagagat                                                   20


<210> 5750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 5750
ttttgggtcc agtggtgttc                                                   20


<210> 5751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 5751
aaaagtcaag atatcaatgc                                                   20


<210> 5752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 5752
tctattaggg aacatgagtg                                                   20


<210> 5753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5753
tggagactga tgaccaaagt                                                   20


<210> 5754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 5754
aggaacagag ggaacatttc                                                   20


<210> 5755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 5755
cctgaggtac atggggtagg                                                   20


<210> 5756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 5756
aaatattctg ctttaagtta                                                   20


<210> 5757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 5757
ctgattgtac acaactcttt                                                   20


<210> 5758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 5758
atgtaaggca tggtggagac                                                   20


<210> 5759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 5759
cacaaatggc aagaaaagaa                                                   20


<210> 5760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 5760
taaaagagca tcacaaatgg                                                   20


<210> 5761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 5761
tggctggata aattgtcaag                                                   20


<210> 5762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 5762
attcagtatg tacccttggt                                                   20


<210> 5763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 5763
agctactcca ttccctaaag                                                   20


<210> 5764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 5764
atagaaatat aataggctct                                                   20


<210> 5765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 5765
gctctcacat actccacttt                                                   20


<210> 5766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 5766
attctttaac attccctgct                                                   20


<210> 5767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5767
cttcaaagtc tagaaccaag                                                   20


<210> 5768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 5768
ccctcttcaa agtctagaac                                                   20


<210> 5769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 5769
gaagtggcag ggatgccaac                                                   20


<210> 5770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5770
acccaacccc ataggctgcc                                                   20


<210> 5771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 5771
caaagtgaaa aacatttaca                                                   20


<210> 5772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5772
ggctaagatg cagcattagt                                                   20


<210> 5773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 5773
aattattgtt gatcgtcttc                                                   20


<210> 5774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 5774
ggggtgaaga tgttgatgtg                                                   20


<210> 5775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 5775
tctcagtctt ctgccagaag                                                   20


<210> 5776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5776
atcttcatga cagaggagca                                                   20


<210> 5777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 5777
catctctgga tccctggaga                                                   20


<210> 5778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 5778
gactgtgact ctagaagccc                                                   20


<210> 5779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 5779
ttgtcctcat ctcctcctct                                                   20


<210> 5780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5780
agaaaatcca aagggcccct                                                   20


<210> 5781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5781
ctaaaggtga gagtttgaat                                                   20


<210> 5782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 5782
agtgaccagg ctggggtcac                                                   20


<210> 5783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 5783
acagatgaga aaactgaggt                                                   20


<210> 5784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 5784
catttctctc attttacaga                                                   20


<210> 5785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 5785
tttgcgtaac tgagatcccg                                                   20


<210> 5786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 5786
cagataacct ctcatgttta                                                   20


<210> 5787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAT

<400> 5787
aaggccatgg cccagcactg                                                   20


<210> 5788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5788
ctgggagaat acaagcaggg                                                   20


<210> 5789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 5789
tgtgttccaa gtgagccctg                                                   20


<210> 5790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 5790
ataattgaca acttcaatca                                                   20


<210> 5791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5791
tctcaaaaaa aaagaaaaga                                                   20


<210> 5792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5792
ctcaatctca aaaaaaaaga                                                   20


<210> 5793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5793
cgagactcaa tctcaaaaaa                                                   20


<210> 5794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 5794
ctgctcggga gactgagaca                                                   20


<210> 5795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5795
cccatctcta ctaaaatatg                                                   20


<210> 5796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 5796
ggtgcatagg gaggaatgag                                                   20


<210> 5797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 5797
gcataaggtg ggaaagtggc                                                   20


<210> 5798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 5798
cacacccagt ttctagacct                                                   20


<210> 5799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 5799
gcttggacac tgatgctgta                                                   20


<210> 5800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 5800
aattacacaa gtgtgggcta                                                   20


<210> 5801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 5801
ctgaatgagt atagaaagag                                                   20


<210> 5802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 5802
atgaagcagc ctgaatgagt                                                   20


<210> 5803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 5803
gttttatgta tggtatttaa                                                   20


<210> 5804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 5804
taattacaaa tggctcccca                                                   20


<210> 5805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 5805
ccctaactgc ctccgtcagg                                                   20


<210> 5806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 5806
aattcagatt actatattcc                                                   20


<210> 5807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 5807
ctagatctca tggacccata                                                   20


<210> 5808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5808
cagtctttgg accaccactt                                                   20


<210> 5809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 5809
gtgcaataag ccactcatcc                                                   20


<210> 5810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 5810
atcataatca gatttgcagt                                                   20


<210> 5811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 5811
accagtgatg tttgggagta                                                   20


<210> 5812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 5812
cagggaacaa tttgatttgg                                                   20


<210> 5813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 5813
ggtggcatta gatgtggggc                                                   20


<210> 5814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 5814
cactcttggg gtggggtggt                                                   20


<210> 5815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 5815
gctttgtaag aaacagaagc                                                   20


<210> 5816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 5816
ttgtcttatg aagtgctttg                                                   20


<210> 5817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5817
ctaagactgg gcaatttata                                                   20


<210> 5818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 5818
tggccagtaa tccctgcatt                                                   20


<210> 5819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 5819
tcctcacacc tggctgcact                                                   20


<210> 5820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 5820
gagccatgaa ctgtgagcac                                                   20


<210> 5821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 5821
gtgagttatt aggtctccat                                                   20


<210> 5822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 5822
tgagcattta gtgaggagtc                                                   20


<210> 5823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5823
tggccctcaa gggctactcc                                                   20


<210> 5824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5824
ccatctccac cagtctgata                                                   20


<210> 5825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 5825
ctacttggga ggctgaggca                                                   20


<210> 5826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 5826
ctagacacag aatcggaagc                                                   20


<210> 5827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 5827
tcttagtcct cgtcctagac                                                   20


<210> 5828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 5828
tccatttccc tatcactcaa                                                   20


<210> 5829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5829
tggaaattat agaaaaaggt                                                   20


<210> 5830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 5830
caaaaaaata cttggaaatt                                                   20


<210> 5831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 5831
cataaatctg tggcagggcc                                                   20


<210> 5832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 5832
taattactcc tttaaagctc                                                   20


<210> 5833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 5833
atggtttctc tgcagcagga                                                   20


<210> 5834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAT

<400> 5834
catgacaagt gggtttccta                                                   20


<210> 5835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 5835
ctcttcaccc atattccagg                                                   20


<210> 5836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5836
tcaatgcttt ctaaaaatac                                                   20


<210> 5837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAT

<400> 5837
cacactgatg ttaattaggg                                                   20


<210> 5838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 5838
gttatcaagc ccttcagctt                                                   20


<210> 5839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 5839
taataacact gccttcaatt                                                   20


<210> 5840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5840
ggaaacgaaa gacaacgcac                                                   20


<210> 5841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 5841
agtgcccagg aaatgacagc                                                   20


<210> 5842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5842
cagggtggtt ctaggtatag                                                   20


<210> 5843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 5843
actccagggt ggttctaggt                                                   20


<210> 5844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 5844
tggccaggtt actaagtggt                                                   20


<210> 5845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 5845
gcagggcctg gaagaaaaag                                                   20


<210> 5846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5846
tggcgtttga gcagggcctg                                                   20


<210> 5847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 5847
aaactttccc tcaactgctc                                                   20


<210> 5848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 5848
gggatgcctc tgcctgcatc                                                   20


<210> 5849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 5849
tagacagaag aaagctaaac                                                   20


<210> 5850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5850
cctcatgagt tttatagaca                                                   20


<210> 5851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 5851
cacggacaac atccaaggcc                                                   20


<210> 5852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 5852
cttccccaat ctgagggggc                                                   20


<210> 5853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 5853
gcttactcat gggtttactg                                                   20


<210> 5854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 5854
agatctaatt tccttaaaat                                                   20


<210> 5855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 5855
ttagaaaaga aagacctggt                                                   20


<210> 5856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5856
aatgagaaca tatgattaga                                                   20


<210> 5857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 5857
gcaggaatga gaacatatga                                                   20


<210> 5858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 5858
aaggtctcca aaagcagtgt                                                   20


<210> 5859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5859
ttgagtaatt tatagcatag                                                   20


<210> 5860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 5860
tgttgtccac tgccccaaga                                                   20


<210> 5861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 5861
gggatctagt cttaaagcag                                                   20


<210> 5862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 5862
ttaattctgc agagcacttt                                                   20


<210> 5863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5863
gactaataat tctatcatct                                                   20


<210> 5864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 5864
atctacctga agtacctcct                                                   20


<210> 5865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 5865
tatctgctat cctaaaaact                                                   20


<210> 5866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 5866
tcttcaaggc agtattttta                                                   20


<210> 5867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5867
aggacaccag gcttttgaga                                                   20


<210> 5868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 5868
agacgaggac accaggcttt                                                   20


<210> 5869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 5869
gtcttccgtt gtgtctggga                                                   20


<210> 5870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5870
ttatggtgaa catgaaaggg                                                   20


<210> 5871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 5871
ccccatgcct ttctcttgca                                                   20


<210> 5872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 5872
gagcccagga ggtcgtggct                                                   20


<210> 5873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5873
taaatttaaa aaagaaaagg                                                   20


<210> 5874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5874
aaataaattt taaatttaaa                                                   20


<210> 5875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 5875
ctacttggga ggctgaggga                                                   20


<210> 5876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 5876
ctactcagga gggtgaggca                                                   20


<210> 5877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 5877
ggagaccagc ctggccaaca                                                   20


<210> 5878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAT

<400> 5878
ggtggctcac gcctgtaatc                                                   20


<210> 5879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 5879
ttcaggaagt tctcttttat                                                   20


<210> 5880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 5880
tggcaggctt tttttaaaga                                                   20


<210> 5881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 5881
tatcaatttt ctgatcccaa                                                   20


<210> 5882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 5882
gatatttaac atttttgtat                                                   20


<210> 5883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 5883
tgcacacttt catattcact                                                   20


<210> 5884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 5884
gtaatccacc taatttactt                                                   20


<210> 5885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5885
aggaaggtgg agggaaaaag                                                   20


<210> 5886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5886
gttgattgat tgaaggaagg                                                   20


<210> 5887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 5887
tcactggttt cccattgctc                                                   20


<210> 5888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 5888
agaaaactgg agcagattga                                                   20


<210> 5889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 5889
ttcaggacag ttttcagttt                                                   20


<210> 5890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 5890
cctgagctgt gagaaatgct                                                   20


<210> 5891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 5891
ccttgtctgc acctgagctg                                                   20


<210> 5892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 5892
ctactcggga ggctgaggca                                                   20


<210> 5893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 5893
ggacagattt ctctaggtat                                                   20


<210> 5894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 5894
aacttgaaaa tcttacaagg                                                   20


<210> 5895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 5895
ttactaattt tccaaaaaag                                                   20


<210> 5896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5896
aaagaaagaa agaaagaaag                                                   20


<210> 5897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5897
aaagaaagaa agaaagaaag                                                   20


<210> 5898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5898
agagaaagaa agaaagaaag                                                   20


<210> 5899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5899
agaaagagaa agaaagaaag                                                   20


<210> 5900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5900
aagaagaaag agaaagaaag                                                   20


<210> 5901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5901
aagaaagaag aaagagaaag                                                   20


<210> 5902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5902
aagaaagaaa gaagaaagag                                                   20


<210> 5903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 5903
gagaaagaaa gaaagaagaa                                                   20


<210> 5904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5904
gaaaaagaga aagaaagaaa                                                   20


<210> 5905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5905
agagaaagaa aaagagaaag                                                   20


<210> 5906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5906
ggagagagaa agaaaaagag                                                   20


<210> 5907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 5907
agagggagag agaaagaaaa                                                   20


<210> 5908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5908
agagagcaag agggagagag                                                   20


<210> 5909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 5909
agagagagag caagagggag                                                   20


<210> 5910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5910
aagcgagaga aagacagatg                                                   20


<210> 5911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 5911
gaataaagat agaaaaagcg                                                   20


<210> 5912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 5912
acagagagag aggaataaag                                                   20


<210> 5913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5913
gagtaagaac ctgtctcaaa                                                   20


<210> 5914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 5914
ctcctgggag ggatgtttac                                                   20


<210> 5915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5915
tgggaatagg aaagaggcct                                                   20


<210> 5916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 5916
cctcaggggt gggtgaggaa                                                   20


<210> 5917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 5917
gcacagcccc tgagaatggt                                                   20


<210> 5918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 5918
actgcagcat gcacagcccc                                                   20


<210> 5919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 5919
ttagagacac acagagccta                                                   20


<210> 5920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 5920
ggttctgacc tctctcagtg                                                   20


<210> 5921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 5921
tttgaatcag tcttgtggca                                                   20


<210> 5922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 5922
aaagtgccac ttttttaaag                                                   20


<210> 5923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 5923
tagaaaagtg gaagcaagag                                                   20


<210> 5924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 5924
cccacaccct cattctacag                                                   20


<210> 5925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 5925
aaaggaaaaa tggaaagaga                                                   20


<210> 5926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 5926
ggaaatgtga ctacttgtcc                                                   20


<210> 5927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 5927
gcacacatga taggcagaag                                                   20


<210> 5928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 5928
agttgagttt agtggccaca                                                   20


<210> 5929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 5929
ttttcaatgt tgtcacttaa                                                   20


<210> 5930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAT

<400> 5930
acaaggtcta gaggatgacc                                                   20


<210> 5931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 5931
atgaaggaat ggaatataat                                                   20


<210> 5932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 5932
aagtgagaaa cagtcatctg                                                   20


<210> 5933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 5933
ttagacgggg gaagaggaag                                                   20


<210> 5934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAA

<400> 5934
agctcatcaa cagagagtaa                                                   20


<210> 5935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 5935
gcactgtgtg gggcacgaag                                                   20


<210> 5936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAA

<400> 5936
ggagctgtag aaggttaagt                                                   20


<210> 5937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 5937
agtcagattc caggggctgc                                                   20


<210> 5938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 5938
aaaagaagtg gagaaatatg                                                   20


<210> 5939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 5939
aacagaaagt gaaaagaagt                                                   20


<210> 5940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 5940
aaaggaaaag ggagacaaaa                                                   20


<210> 5941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 5941
aaaacacaga gaagctaagg                                                   20


<210> 5942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 5942
gcctagtgtt caggaaggga                                                   20


<210> 5943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 5943
tttatagata aacctaaagc                                                   20


<210> 5944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5944
aatgaagaaa attgaaaaaa                                                   20


<210> 5945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5945
aaaatttaaa ataaaaaaat                                                   20


<210> 5946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5946
acttaaagta taatttaaaa                                                   20


<210> 5947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 5947
gtattttcca agccttgtag                                                   20


<210> 5948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5948
aaaaagtgaa actacaaaag                                                   20


<210> 5949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5949
gtgaaaaaag tgaaactaca                                                   20


<210> 5950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 5950
taaatagtct gatctgtgga                                                   20


<210> 5951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 5951
cagactcctg cagtggcagg                                                   20


<210> 5952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5952
agagagactg aagattaagg                                                   20


<210> 5953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 5953
atgctaatgg gaaggatctg                                                   20


<210> 5954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 5954
aagatggcac tagggagtag                                                   20


<210> 5955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5955
ttaaagagcg ggtgagaggt                                                   20


<210> 5956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 5956
taaaaatttc ttcagaaaga                                                   20


<210> 5957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 5957
aagagtaaaa atttcttcag                                                   20


<210> 5958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 5958
agccaagagt aaaaatttct                                                   20


<210> 5959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 5959
cagaaatagg aaaagatcta                                                   20


<210> 5960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 5960
aggagactga aaaggaaggt                                                   20


<210> 5961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 5961
gatgagttgg ggccagatcc                                                   20


<210> 5962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 5962
aaaggactgc aaagcagaag                                                   20


<210> 5963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAT

<400> 5963
agatttcact gttgtccaag                                                   20


<210> 5964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 5964
tctttaagag ggattatgct                                                   20


<210> 5965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 5965
cagagaaaca atgatgtttt                                                   20


<210> 5966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 5966
acagtagagt aagaaaggcc                                                   20


<210> 5967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 5967
aagatgctgt gacagtagag                                                   20


<210> 5968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5968
cagtgtgaac tgataaaaag                                                   20


<210> 5969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 5969
atttttagcc tgtaaagtag                                                   20


<210> 5970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 5970
agcaagtaca atgcattctg                                                   20


<210> 5971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 5971
tcagctatgt aagaagctga                                                   20


<210> 5972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 5972
gaaaattctc tccaagaaga                                                   20


<210> 5973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 5973
atattcagat ataagaagta                                                   20


<210> 5974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 5974
cttctaacat ttttcatggc                                                   20


<210> 5975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 5975
gcatacctga gtttgtgctt                                                   20


<210> 5976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAT

<400> 5976
tcagagagag ccctgtggct                                                   20


<210> 5977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 5977
aggagaaaca aagacgtttt                                                   20


<210> 5978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 5978
agagtagagt aagaaaggca                                                   20


<210> 5979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 5979
aagatactgt gagagtagag                                                   20


<210> 5980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5980
tggtgtaaac tgataaaaag                                                   20


<210> 5981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 5981
ttagagagag attcacatgc                                                   20


<210> 5982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 5982
aggggaagaa gtggtgagca                                                   20


<210> 5983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 5983
ctttttttgc cttagggtat                                                   20


<210> 5984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 5984
ttaactaagt ccttgttaat                                                   20


<210> 5985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 5985
caggccagct ctccggtgta                                                   20


<210> 5986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 5986
aaagtgatct ggcaggcatc                                                   20


<210> 5987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAT

<400> 5987
aaaagaagac tttcttgtca                                                   20


<210> 5988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 5988
aaatacaatg taggatattc                                                   20


<210> 5989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 5989
gctgggagtg cattagcact                                                   20


<210> 5990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAT

<400> 5990
tgaagggatg aaggaaagga                                                   20


<210> 5991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 5991
aataagggac agtgaggcac                                                   20


<210> 5992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 5992
catgtgattc agggtcccag                                                   20


<210> 5993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 5993
gggatacagc gcaattgcag                                                   20


<210> 5994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 5994
taactggcca gcactcttta                                                   20


<210> 5995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 5995
tattccttgc tttactcaca                                                   20


<210> 5996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 5996
aggctgggca aatggcaccc                                                   20


<210> 5997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 5997
gctttcttgt tggacaggta                                                   20


<210> 5998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAT

<400> 5998
tttttcccca ccatgcatac                                                   20


<210> 5999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 5999
tgttcaagcc tcgagggatc                                                   20


<210> 6000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6000
ctaaagccat tttataacca                                                   20


<210> 6001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6001
tggggaggag tattttcctg                                                   20


<210> 6002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6002
cttatggggc tggataggta                                                   20


<210> 6003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6003
atggtgtttt gagaatcagg                                                   20


<210> 6004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 6004
gagacacata catggtgttt                                                   20


<210> 6005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6005
caagctgtca cctgttgtta                                                   20


<210> 6006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6006
agtgggaaga ggtgtgtggc                                                   20


<210> 6007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 6007
aaatgccagt gagagaaggc                                                   20


<210> 6008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 6008
agccaaaaga gacttttttt                                                   20


<210> 6009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 6009
gagaaagcga atgaagcaaa                                                   20


<210> 6010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6010
ctattgaggg agtgctctca                                                   20


<210> 6011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6011
gcgtccccgt tttatggata                                                   20


<210> 6012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6012
ttaaagggag agagaagaac                                                   20


<210> 6013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6013
cccccagatt ccttatctgt                                                   20


<210> 6014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6014
aggtaaataa aacaggagaa                                                   20


<210> 6015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6015
gaatgcaggt aaataaaaca                                                   20


<210> 6016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6016
atggagaaat cctgggagta                                                   20


<210> 6017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6017
ccccagaggt tggagttcat                                                   20


<210> 6018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 6018
ggagatagac ttggaactga                                                   20


<210> 6019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6019
aggctgccct cagagttaat                                                   20


<210> 6020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6020
ggtggatttc tacagaagac                                                   20


<210> 6021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6021
ctcaaggcag aaaatggata                                                   20


<210> 6022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6022
ggaaggtcag gggtctcaag                                                   20


<210> 6023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6023
gccactggag gaaggcatga                                                   20


<210> 6024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 6024
agaccattcc aggtggcaga                                                   20


<210> 6025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6025
aggtggcggt gtgaggcaag                                                   20


<210> 6026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 6026
agggtgtgga tacatagaga                                                   20


<210> 6027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6027
ccagtagaga tccaagagac                                                   20


<210> 6028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6028
ctgttctcat ggcagtgttc                                                   20


<210> 6029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6029
gacaaccaac tactcatctc                                                   20


<210> 6030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 6030
aacctcaaaa ataaatgtgt                                                   20


<210> 6031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6031
ggggccctga ttcactcagt                                                   20


<210> 6032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6032
gagtaaatgc aagcttcgga                                                   20


<210> 6033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 6033
cagttgcatc gtctttataa                                                   20


<210> 6034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6034
aagctgcctc ccagatgcat                                                   20


<210> 6035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6035
attcgttctc ttatctgtaa                                                   20


<210> 6036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 6036
taggttctct cctctcaccc                                                   20


<210> 6037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6037
aattcttgat tactgagaat                                                   20


<210> 6038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 6038
attaggcaat tcttgattac                                                   20


<210> 6039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6039
ctttagacac ccagaggaaa                                                   20


<210> 6040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6040
acttggaaat ggggaggaag                                                   20


<210> 6041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6041
ctgacatggc ggtctccttc                                                   20


<210> 6042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6042
agttagcctg tcacagtgga                                                   20


<210> 6043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6043
aaatctcaga aatcagcgtt                                                   20


<210> 6044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6044
ggtgatggtg caccaaaatc                                                   20


<210> 6045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6045
ctaaatgaag taactcagga                                                   20


<210> 6046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6046
ccatcaacca acaagtgcat                                                   20


<210> 6047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 6047
gagataccac cttactcctg                                                   20


<210> 6048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 6048
atccaaaagt gggcaaagga                                                   20


<210> 6049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6049
aagaaacaca aataaatcag                                                   20


<210> 6050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6050
agactaatat ccagcatcta                                                   20


<210> 6051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6051
aacagacaac ccataggatg                                                   20


<210> 6052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6052
taaaaagctg ttgcacagca                                                   20


<210> 6053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6053
tagcaagcca catgtggaag                                                   20


<210> 6054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6054
taattagcaa gccacatgtg                                                   20


<210> 6055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6055
aatggaaaag aatagagaac                                                   20


<210> 6056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6056
taagcacata gaccaatgga                                                   20


<210> 6057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 6057
atagccaaag caagactaag                                                   20


<210> 6058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6058
ccacatcatt cttcacagaa                                                   20


<210> 6059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6059
gaagtaccac atcattcttc                                                   20


<210> 6060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6060
agcagcacta ctgtacacca                                                   20


<210> 6061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6061
ctagccagag caatcagaca                                                   20


<210> 6062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 6062
aaatgctgca cgtcacataa                                                   20


<210> 6063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6063
gtatcaccct aataccaaaa                                                   20


<210> 6064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6064
ttgaaactat tccaaaagat                                                   20


<210> 6065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6065
aattctatca gacattcaaa                                                   20


<210> 6066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6066
ttagattaaa tcagaaagta                                                   20


<210> 6067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6067
tacaactgtc ttagattaaa                                                   20


<210> 6068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 6068
aacaccttta tttgcacaaa                                                   20


<210> 6069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6069
gagatattac aactgatacc                                                   20


<210> 6070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6070
gaagatccaa ataagctcaa                                                   20


<210> 6071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6071
tgaccattgg caagattaac                                                   20


<210> 6072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6072
agcgggttct ttaaaaagat                                                   20


<210> 6073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6073
aaacagaccc aaaccaagca                                                   20


<210> 6074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6074
aggtcacacc tcaaggaatt                                                   20


<210> 6075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6075
aaacctcgga gttaactcca                                                   20


<210> 6076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6076
atctcaataa atttaagaaa                                                   20


<210> 6077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6077
ataacaaatc tcaataaatt                                                   20


<210> 6078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAT

<400> 6078
aaacattcta ccaaacaact                                                   20


<210> 6079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6079
catcaagaca gaaagtcaac                                                   20


<210> 6080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6080
gcactagaca ggtcatcaag                                                   20


<210> 6081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6081
aaaacaatta ctactagacc                                                   20


<210> 6082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6082
ggagtagcta ttcttatatc                                                   20


<210> 6083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6083
cacttaaaat atacagaagg                                                   20


<210> 6084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6084
ccactaccaa gccagcacta                                                   20


<210> 6085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6085
tttcagacaa acaaatggtg                                                   20


<210> 6086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6086
cagccaagaa tattgtatga                                                   20


<210> 6087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 6087
gaaacaaaat aattgccagc                                                   20


<210> 6088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6088
atctaaagtc aagacaaaga                                                   20


<210> 6089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6089
aggttatcta aagtcaagac                                                   20


<210> 6090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6090
tatccaaata caagaagctc                                                   20


<210> 6091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6091
ggaaaacttc cctggccttg                                                   20


<210> 6092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6092
atgggtgttc ccaaggaaga                                                   20


<210> 6093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6093
gaataatggg tgttcccaag                                                   20


<210> 6094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAT

<400> 6094
tcatgtgaaa caaccaaacc                                                   20


<210> 6095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6095
aaactaagac acacaaaaag                                                   20


<210> 6096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6096
acccaaacta agacacacaa                                                   20


<210> 6097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6097
acaatagact agaacaagta                                                   20


<210> 6098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6098
tggaaatgga agactcactt                                                   20


<210> 6099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6099
ttctccagag aaatagatat                                                   20


<210> 6100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6100
atatggatgg aaaattctcc                                                   20


<210> 6101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6101
agaaagataa aaaccaactt                                                   20


<210> 6102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6102
aagtgattca aggagacacc                                                   20


<210> 6103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6103
ccatctcaaa aaaaaaaaaa                                                   20


<210> 6104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 6104
ctactcagga gactgaggca                                                   20


<210> 6105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6105
gaccagcctg aagccaacat                                                   20


<210> 6106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6106
aaatctctga attgccagat                                                   20


<210> 6107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6107
caacaatgga tccaaactaa                                                   20


<210> 6108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6108
tctactcaaa tgagaaggaa                                                   20


<210> 6109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6109
aagagatcac ccatgaaaca                                                   20


<210> 6110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6110
ctgctaacat aactagcatt                                                   20


<210> 6111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6111
aataactttg atcccaggaa                                                   20


<210> 6112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 6112
ggccattaaa gcaactcatg                                                   20


<210> 6113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6113
ttatggccct gctcatcacc                                                   20


<210> 6114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6114
ttggtagctg aacacaaaac                                                   20


<210> 6115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAT

<400> 6115
ctgggcacaa attttcttga                                                   20


<210> 6116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAA

<400> 6116
aagccacaca aaatataaaa                                                   20


<210> 6117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6117
tgaaaatcca gatcacagga                                                   20


<210> 6118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6118
ggaatatacc aggagaactg                                                   20


<210> 6119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 6119
ggccctggca gacataaaca                                                   20


<210> 6120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 6120
tggatggcat aaagcagcat                                                   20


<210> 6121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6121
gcatccaatc catttctgga                                                   20


<210> 6122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6122
tttccctctt cttcaactct                                                   20


<210> 6123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6123
gctagggaaa gacttctgta                                                   20


<210> 6124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6124
tatttattgg cttcctatta                                                   20


<210> 6125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6125
ctgagttaag attttctaat                                                   20


<210> 6126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6126
tctgtgtttg atttgacaaa                                                   20


<210> 6127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6127
tgaatgctgc aacccaacat                                                   20


<210> 6128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6128
ccaatgattt tcttcattca                                                   20


<210> 6129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6129
tgggtatctc agtgatccat                                                   20


<210> 6130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6130
aaaggtgtta aattgccatt                                                   20


<210> 6131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 6131
caaattcatg gagacagaaa                                                   20


<210> 6132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6132
gaacaggcaa attcatggag                                                   20


<210> 6133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6133
tattgtggtt ggagaagaaa                                                   20


<210> 6134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6134
ttacaaatat tgtggttgga                                                   20


<210> 6135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6135
caaaaccaga caaaaatata                                                   20


<210> 6136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6136
gcataacaat aatgataaaa                                                   20


<210> 6137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 6137
taagattaat tattatattc                                                   20


<210> 6138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6138
gaattgattt atcaccacag                                                   20


<210> 6139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAT

<400> 6139
catttaggta tttcaatctc                                                   20


<210> 6140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6140
tctccccatg ccctggtttc                                                   20


<210> 6141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6141
taatcccctc ttttgcttgg                                                   20


<210> 6142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6142
aaattgtagc cagtgaggaa                                                   20


<210> 6143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 6143
ttaaggatga atttctagaa                                                   20


<210> 6144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6144
atcccagcag cagctgtttt                                                   20


<210> 6145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 6145
gattagaaga ttcataattg                                                   20


<210> 6146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6146
aaaataatac agcattattg                                                   20


<210> 6147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6147
aaaaagcaat aaattacaaa                                                   20


<210> 6148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6148
tagaaaaagg ataacaaatg                                                   20


<210> 6149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 6149
tatttaaaga cctaacaaaa                                                   20


<210> 6150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6150
tttatatcag taaaagctga                                                   20


<210> 6151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 6151
ataagtcaca gcatggaagc                                                   20


<210> 6152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6152
aatttttaaa aatctctctt                                                   20


<210> 6153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6153
ctccagaaag tggaaataat                                                   20


<210> 6154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6154
gacaaaaacc tcaataagct                                                   20


<210> 6155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6155
gcaaactacc ttccctaaca                                                   20


<210> 6156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6156
taaataaaaa cattgtagga                                                   20


<210> 6157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6157
atggcaacaa tatttataaa                                                   20


<210> 6158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6158
ggatccatga ttttaatatc                                                   20


<210> 6159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6159
agacataagc aaaggcaaac                                                   20


<210> 6160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 6160
gatacagaaa ggctaaaatt                                                   20


<210> 6161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6161
aaaatactcc tcacggtgat                                                   20


<210> 6162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAT

<400> 6162
ataacatggt cacatttatt                                                   20


<210> 6163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6163
gtcattagca aaaaaaaaag                                                   20


<210> 6164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6164
caacccattt tgaactcaaa                                                   20


<210> 6165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 6165
gcttcaactg ccgaatgacc                                                   20


<210> 6166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 6166
aaatagttca tttttgttgc                                                   20


<210> 6167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6167
atcgcacatc acaatctgat                                                   20


<210> 6168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6168
tgtaatggct ttgctgggat                                                   20


<210> 6169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6169
atgcagtcgg ttgttgtgga                                                   20


<210> 6170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6170
aatcaacaca tttttgccaa                                                   20


<210> 6171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6171
atgacaaact ctaaatactg                                                   20


<210> 6172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6172
ggaaatgaga gattttgatt                                                   20


<210> 6173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6173
attatttaaa gttgacaaat                                                   20


<210> 6174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6174
acaaatagca agaaatggaa                                                   20


<210> 6175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6175
tgttgacatg atacaaatag                                                   20


<210> 6176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 6176
cctccagagg gggataaaaa                                                   20


<210> 6177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6177
atatacaaga acaaagagaa                                                   20


<210> 6178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6178
gtataaatat acaagaacaa                                                   20


<210> 6179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 6179
cccaccctct caaaatgcca                                                   20


<210> 6180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 6180
attgtggtta aatatggaag                                                   20


<210> 6181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6181
tcagaagatg gttactaagt                                                   20


<210> 6182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6182
ggcttcaacc tccagatttg                                                   20


<210> 6183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 6183
acaaggtaga catctataag                                                   20


<210> 6184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6184
gtagaactgg tgtccttata                                                   20


<210> 6185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 6185
agaaaaagta ccaaaaatta                                                   20


<210> 6186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6186
aaagcatcaa taaagtaagg                                                   20


<210> 6187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6187
acaacaataa ggatgagtct                                                   20


<210> 6188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6188
atttctgtta tattctaaaa                                                   20


<210> 6189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6189
tggacaccag attacagcta                                                   20


<210> 6190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6190
cccttaggta cctatgttta                                                   20


<210> 6191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6191
attgggaatg acatggagca                                                   20


<210> 6192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6192
taatgaactc tacaaatcaa                                                   20


<210> 6193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAT

<400> 6193
acattttagt atactataat                                                   20


<210> 6194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6194
atatctttat gacctcagac                                                   20


<210> 6195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6195
gtagattttt ctaattctgt                                                   20


<210> 6196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 6196
tccaactttc ttctttttgc                                                   20


<210> 6197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 6197
cgcatgcttg tatctttata                                                   20


<210> 6198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 6198
ctgttcttat gtcagtttgc                                                   20


<210> 6199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6199
ttaagttctg gggtacatgt                                                   20


<210> 6200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 6200
atccaacttt gcaccacaca                                                   20


<210> 6201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6201
ggtcttcaaa aaatgatgct                                                   20


<210> 6202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6202
tgccattggt gtaagattgg                                                   20


<210> 6203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6203
atagccaaga aacttttgag                                                   20


<210> 6204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6204
tttaaagagc aaattatagc                                                   20


<210> 6205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6205
aagtattgtg taaagttttt                                                   20


<210> 6206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6206
tgtatagaca ctagcaacaa                                                   20


<210> 6207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAT

<400> 6207
cataacctag agataaacag                                                   20


<210> 6208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6208
caaagaaaaa aaaagtgcaa                                                   20


<210> 6209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6209
ctcagccagc atagtaaagc                                                   20


<210> 6210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6210
aagctttccc tttgagatca                                                   20


<210> 6211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6211
ctaggggagg gatagcatta                                                   20


<210> 6212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6212
ctcagcaaac taacacaaga                                                   20


<210> 6213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6213
ccatttataa ttttaaattc                                                   20


<210> 6214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6214
taacagtaat gcatgccaca                                                   20


<210> 6215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6215
tgggtgaaac ccctatagtt                                                   20


<210> 6216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6216
caaatggctc tggagtatat                                                   20


<210> 6217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6217
taaatgcctg agtcccagcc                                                   20


<210> 6218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6218
atgacccgaa ctgaccttcc                                                   20


<210> 6219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6219
ggttgactag ctgcatgacc                                                   20


<210> 6220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 6220
ttctaacttt tctttgtctt                                                   20


<210> 6221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6221
gttgggagcc cagctattcc                                                   20


<210> 6222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6222
ctagacacat caaggcattt                                                   20


<210> 6223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 6223
aggaaaatgt ggtttaatta                                                   20


<210> 6224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 6224
tatattactt ttaaatattt                                                   20


<210> 6225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAT

<400> 6225
aactccagcc ccaaaagata                                                   20


<210> 6226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6226
cttggtagag tcacagctgg                                                   20


<210> 6227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6227
gataagtaag aaacagctaa                                                   20


<210> 6228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6228
ttgaattaca tctggataag                                                   20


<210> 6229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6229
tacatggaaa ttacaaataa                                                   20


<210> 6230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 6230
ttttctttct ggctggccag                                                   20


<210> 6231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 6231
gcttgcagga ggttgatgta                                                   20


<210> 6232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAA

<400> 6232
ttgcaaggca agccaaacta                                                   20


<210> 6233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6233
aggatggttc tcttgtcaga                                                   20


<210> 6234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6234
agatgtagaa ggtggagaca                                                   20


<210> 6235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6235
atcctcctaa atcctcagag                                                   20


<210> 6236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 6236
atccctgaaa tcaaaaagtt                                                   20


<210> 6237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6237
ggaggagcat ggcggtgagg                                                   20


<210> 6238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6238
gaatttttat gacatttatg                                                   20


<210> 6239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6239
aagtctcggt cccacccagc                                                   20


<210> 6240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6240
attgctgcca agcagggaac                                                   20


<210> 6241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6241
gagtataaat acttcctgaa                                                   20


<210> 6242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6242
caataaataa aagattgtga                                                   20


<210> 6243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6243
caaatgaaat tcaaacaggt                                                   20


<210> 6244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6244
agactgaacc tggaggtccc                                                   20


<210> 6245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6245
gtatttgaaa cctcagacta                                                   20


<210> 6246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6246
caagggaaga cagggaatag                                                   20


<210> 6247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 6247
cagagggaaa ggaatggtcc                                                   20


<210> 6248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6248
aagagctggc agacaaggag                                                   20


<210> 6249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6249
aaaaaaaaaa agaaaaagaa                                                   20


<210> 6250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6250
tctcaaaaaa aaaaaaagaa                                                   20


<210> 6251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6251
accctgtctc aaaaaaaaaa                                                   20


<210> 6252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 6252
ctattcggga ggctgaggtg                                                   20


<210> 6253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6253
gagagactga gaaggagaag                                                   20


<210> 6254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6254
caatcatgta tgggaaaagc                                                   20


<210> 6255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6255
acatagaaga gaggcaggta                                                   20


<210> 6256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6256
tacccaggtt gtggacagac                                                   20


<210> 6257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6257
ttgattgtat gtggaatgaa                                                   20


<210> 6258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6258
ggccactgtt ggagaatagg                                                   20


<210> 6259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 6259
aatatcattt ggccactgtt                                                   20


<210> 6260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6260
cacataacca gattttcatt                                                   20


<210> 6261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 6261
cttgagtgct atggagagct                                                   20


<210> 6262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6262
tggaaaagcc ttaacataaa                                                   20


<210> 6263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 6263
ttgtctcaaa gccaagagta                                                   20


<210> 6264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6264
cttcatatag gtcagaaatg                                                   20


<210> 6265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6265
taacatagac ttcatatagg                                                   20


<210> 6266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6266
attacaaatc agatgtttat                                                   20


<210> 6267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6267
tagaaacaat agaaaggcaa                                                   20


<210> 6268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6268
cttacaattt ggtagaaaca                                                   20


<210> 6269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAA

<400> 6269
ctcactgagc ttacaatttg                                                   20


<210> 6270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6270
tatcacagag gtattggatt                                                   20


<210> 6271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6271
agggtgaggg aaagctctca                                                   20


<210> 6272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6272
gttgactttg aaaagttccg                                                   20


<210> 6273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6273
cacatagaac ttctaagtta                                                   20


<210> 6274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6274
gcataaatac accatgttaa                                                   20


<210> 6275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6275
aatctttgtt tctcagaagg                                                   20


<210> 6276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6276
tcttctcccc tagacaagga                                                   20


<210> 6277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6277
attgcattcc agtgtcactg                                                   20


<210> 6278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAT

<400> 6278
ctggagggat ttatggtagc                                                   20


<210> 6279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6279
cttgcacccc aatagttttc                                                   20


<210> 6280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 6280
tcctctcttc tatgacattc                                                   20


<210> 6281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAT

<400> 6281
gggccgagct tggagctaaa                                                   20


<210> 6282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6282
gagggctgaa tgcccaccga                                                   20


<210> 6283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 6283
ttttgtgtgg ctttctgtaa                                                   20


<210> 6284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 6284
ttgtccttgc gatagtttgc                                                   20


<210> 6285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6285
cccattcaca attgcttcaa                                                   20


<210> 6286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6286
aaagaggata caaacaaatg                                                   20


<210> 6287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6287
tactccatgc tcatgggtag                                                   20


<210> 6288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6288
agctaccaat gactttcttc                                                   20


<210> 6289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6289
ttttttactt tttagcatta                                                   20


<210> 6290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAT

<400> 6290
gtacattgtg cacatgtacc                                                   20


<210> 6291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6291
tttaaagtat aattttaaaa                                                   20


<210> 6292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6292
aatttaggaa atgcatttgt                                                   20


<210> 6293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6293
atgcatttgt gcagaaaaaa                                                   20


<210> 6294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6294
tgggatgctg taacaaatta                                                   20


<210> 6295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6295
aaactaggta gatgacaata                                                   20


<210> 6296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 6296
actcaaagta aaaatacttt                                                   20


<210> 6297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 6297
tatttggttg aactcatctt                                                   20


<210> 6298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6298
ttagaataaa tcaggcattc                                                   20


<210> 6299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6299
cttcttatgg gctaatagtg                                                   20


<210> 6300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6300
taacatttgc aggatgaatg                                                   20


<210> 6301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6301
gctgcctctt tagctacaca                                                   20


<210> 6302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6302
aaggtccagc catttcagcc                                                   20


<210> 6303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6303
cagcacgaga tgcgaagtct                                                   20


<210> 6304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6304
aactgaaaaa tatcaggatc                                                   20


<210> 6305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6305
tcatgataca ggtcagcatc                                                   20


<210> 6306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6306
aggtcagcat cacagaaata                                                   20


<210> 6307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6307
tctcctccat atttgccttc                                                   20


<210> 6308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6308
tgtctgcaaa gtccgagaga                                                   20


<210> 6309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAT

<400> 6309
cgtggccaca ttgaagttct                                                   20


<210> 6310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAT

<400> 6310
gaagtaactt tgaagtgact                                                   20


<210> 6311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6311
tttgaagtga cttaagaatt                                                   20


<210> 6312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6312
aatcaggcct ttaaaagaag                                                   20


<210> 6313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAT

<400> 6313
catgttatct ttgcctccgc                                                   20


<210> 6314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6314
atgaacaaag ttggaaatat                                                   20


<210> 6315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6315
caatattgtg ttggaaagag                                                   20


<210> 6316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 6316
ctccaggatc ttattttaag                                                   20


<210> 6317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6317
cacctcttgt tggtgggaaa                                                   20


<210> 6318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAA

<400> 6318
aagggaggta aggagagagg                                                   20


<210> 6319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6319
atagtcaaac tcatgggagc                                                   20


<210> 6320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 6320
caaactcatg ggagcagaga                                                   20


<210> 6321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6321
gtctacctaa aaatttgcca                                                   20


<210> 6322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 6322
ttaattccag accctagact                                                   20


<210> 6323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAT

<400> 6323
aaagaactgg ttgattttgc                                                   20


<210> 6324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6324
caaaaccctg gaacttgttc                                                   20


<210> 6325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAT

<400> 6325
ctagtttctc ctaacttaaa                                                   20


<210> 6326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6326
ctaacttaaa gcagaatatt                                                   20


<210> 6327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 6327
aatttgtaaa tgaatggaag                                                   20


<210> 6328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6328
ctatcctgtt gggttagagc                                                   20


<210> 6329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6329
tttctgtagc agggaatgtt                                                   20


<210> 6330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6330
aatccttaac ttttcctatg                                                   20


<210> 6331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6331
ggcacccatg cactgatggg                                                   20


<210> 6332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAT

<400> 6332
gagtgtttac cttgcttggg                                                   20


<210> 6333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 6333
tcttcttcca ttcaaaggat                                                   20


<210> 6334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 6334
aaggatggag aatctcagga                                                   20


<210> 6335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6335
tcttagttgc agcttaatta                                                   20


<210> 6336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAT

<400> 6336
aaatatgatt tatcttgtcc                                                   20


<210> 6337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6337
tgattgtatg ggtgatttag                                                   20


<210> 6338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6338
ccccattgta atacttctta                                                   20


<210> 6339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 6339
aaaatctaat agcttggcta                                                   20


<210> 6340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6340
actaatgctg catcttagcc                                                   20


<210> 6341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6341
cattcactgg agtggatggc                                                   20


<210> 6342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 6342
tctatacctg taggcgtggg                                                   20


<210> 6343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6343
acttgaactc taaaactgtt                                                   20


<210> 6344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6344
ccaaaatcag aacaggcagg                                                   20


<210> 6345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6345
tgccctctgc tgttacagtg                                                   20


<210> 6346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6346
gttttctcat ctgtaaaatg                                                   20


<210> 6347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6347
tcccctctgc tgttacagtg                                                   20


<210> 6348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6348
tattagcccc attgaatgaa                                                   20


<210> 6349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6349
tagtggggca ttgctgacag                                                   20


<210> 6350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6350
atataaggct taccactaca                                                   20


<210> 6351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6351
gcttaccact acagcagaaa                                                   20


<210> 6352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6352
agcaggaatg agggagtggg                                                   20


<210> 6353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6353
aagccctgga gtctttatac                                                   20


<210> 6354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 6354
tcaaatgcag actgatatgg                                                   20


<210> 6355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6355
ctgtgttgga aagggcttgt                                                   20


<210> 6356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6356
gttggaaagg gcttgtgcag                                                   20


<210> 6357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAT

<400> 6357
taatcccaca tgtggctgtt                                                   20


<210> 6358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6358
cattaaagac acagagcctt                                                   20


<210> 6359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAT

<400> 6359
cccaccttat gcacatgatg                                                   20


<210> 6360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 6360
tatcttccag atggagaagt                                                   20


<210> 6361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 6361
agctttagca ttcttgaggt                                                   20


<210> 6362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6362
aatgaacagg tagatgaagg                                                   20


<210> 6363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6363
gagtgattga ctggatgatg                                                   20


<210> 6364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6364
gattgactgg atgatgaaag                                                   20


<210> 6365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6365
atggtgtagt ctgtaggaat                                                   20


<210> 6366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6366
accaccacct ggtgggagat                                                   20


<210> 6367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 6367
cttatttgta aataagcaaa                                                   20


<210> 6368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 6368
gagaatctat tagatacaaa                                                   20


<210> 6369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CGAGAAA

<400> 6369
ttacccgcat gccttcaaat                                                   20


<210> 6370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6370
gggctttgat gggagccact                                                   20


<210> 6371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAT

<400> 6371
gggagccact tcagaatatt                                                   20


<210> 6372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6372
agatctgagt gcaggagagg                                                   20


<210> 6373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6373
agaaacatca ctctaggttt                                                   20


<210> 6374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 6374
tcggaactcc aatgagaggt                                                   20


<210> 6375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6375
actctcttaa acaatctggg                                                   20


<210> 6376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6376
tgctcagaga agtggggtgg                                                   20


<210> 6377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6377
aaaatgaaaa agtcagacta                                                   20


<210> 6378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6378
tggtccaaag actgcaaagg                                                   20


<210> 6379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6379
gtgggatgca cacaggagct                                                   20


<210> 6380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6380
tctaatgcca cctcccatag                                                   20


<210> 6381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6381
agttagatgt atagcaaatg                                                   20


<210> 6382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6382
tcattgggat ggctagaagg                                                   20


<210> 6383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6383
tgggatggct agaaggaaag                                                   20


<210> 6384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6384
tagctgctct tgccacaggg                                                   20


<210> 6385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6385
gatagttgaa tggaaggatg                                                   20


<210> 6386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6386
ggaaggatgg gagaaacaaa                                                   20


<210> 6387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 6387
atggaaagat ggggagctgg                                                   20


<210> 6388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6388
gatgaatgaa cagataagtg                                                   20


<210> 6389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6389
aacagataag tggaagaaag                                                   20


<210> 6390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 6390
aatagatgga taggttgaaa                                                   20


<210> 6391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6391
gaaacaagaa tggaaagata                                                   20


<210> 6392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 6392
gaagatgcgt gaatgagtga                                                   20


<210> 6393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6393
gatgattgga cagttggata                                                   20


<210> 6394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6394
atagaagaat gaatcaaaag                                                   20


<210> 6395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 6395
atgaatagat ggaaggaagt                                                   20


<210> 6396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6396
ggcagaagag aagagggaaa                                                   20


<210> 6397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6397
ctgatgaaga tgtacagctg                                                   20


<210> 6398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6398
gaaggatgga tggttggaag                                                   20


<210> 6399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 6399
tgaataatta tttcatatgc                                                   20


<210> 6400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6400
tgcattggca tcagggaaga                                                   20


<210> 6401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 6401
ctgccagcac aggaggctgg                                                   20


<210> 6402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6402
gcacatgcct caccctgctt                                                   20


<210> 6403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6403
accacccaag accaataaga                                                   20


<210> 6404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6404
agtcttcaaa ggcctggaag                                                   20


<210> 6405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAT

<400> 6405
gcctggaagg aagaaaggat                                                   20


<210> 6406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6406
gcagggatgc tgaatgcaag                                                   20


<210> 6407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6407
ggatgctgaa tgcaagggag                                                   20


<210> 6408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAT

<400> 6408
gcagtttaca aaaatgaaag                                                   20


<210> 6409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6409
atcgccaaca cacctctgaa                                                   20


<210> 6410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6410
atcagactgg tggagatgga                                                   20


<210> 6411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6411
gataatatga gactatttac                                                   20


<210> 6412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 6412
gagaaaaatg tactgaggtt                                                   20


<210> 6413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6413
tattttatgc ataagcaaga                                                   20


<210> 6414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6414
aaggagaaga gcataggtgt                                                   20


<210> 6415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6415
ttgggctttg acttcctcat                                                   20


<210> 6416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6416
aagcatcacc tgggagcttg                                                   20


<210> 6417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 6417
cctgccacag atttatggaa                                                   20


<210> 6418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6418
ataatttctg ctcctgctgc                                                   20


<210> 6419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6419
aaaaattttt ctttgtattt                                                   20


<210> 6420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 6420
ttgaggccac aattcccttt                                                   20


<210> 6421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 6421
ttcattgcac aaatatttat                                                   20


<210> 6422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6422
tgcctagccg gggtcatgga                                                   20


<210> 6423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAT

<400> 6423
aagaagcatg acatccacgt                                                   20


<210> 6424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6424
gccccaggct acttttgcct                                                   20


<210> 6425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6425
tagagaaaat gatgtggaca                                                   20


<210> 6426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 6426
tgtggacaaa agaaagtggg                                                   20


<210> 6427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6427
gactttaaaa attcccagga                                                   20


<210> 6428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAT

<400> 6428
agctggctaa atgagtcaca                                                   20


<210> 6429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6429
ttggacaaca tcctgttctt                                                   20


<210> 6430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6430
gttgtgaaga caaaatgata                                                   20


<210> 6431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6431
ttggttgatg tccagggcaa                                                   20


<210> 6432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6432
agctaggacc tgtgcagctt                                                   20


<210> 6433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6433
ttccctagca ccatcaccgt                                                   20


<210> 6434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6434
gcttgaatac gcgcagctgc                                                   20


<210> 6435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6435
ggaaccaatg gtttagttac                                                   20


<210> 6436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 6436
atgaaccaca aacaatccca                                                   20


<210> 6437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 6437
actacctagg tattttaagt                                                   20


<210> 6438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAT

<400> 6438
gcaattctac aaagtgctct                                                   20


<210> 6439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6439
tcaagagtga atgagatctt                                                   20


<210> 6440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 6440
tcattccatt tcttcagatg                                                   20


<210> 6441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6441
ataattagat ataatatgtt                                                   20


<210> 6442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6442
aataacttga aactatgtgc                                                   20


<210> 6443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6443
aagttgtgaa aaatacactc                                                   20


<210> 6444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6444
cagatttgac acagtttggg                                                   20


<210> 6445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6445
attagtgaac tgaggatata                                                   20


<210> 6446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6446
gatatatcag aataaattat                                                   20


<210> 6447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 6447
tagtgtaaga gacatagagg                                                   20


<210> 6448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6448
tatctaacca aagtccagaa                                                   20


<210> 6449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 6449
aaagtccaga aggagaaaaa                                                   20


<210> 6450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAT

<400> 6450
acatcatgtc tgggaacttt                                                   20


<210> 6451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6451
tctgggaact ttccagaatt                                                   20


<210> 6452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6452
atagaagatt taaaaagcat                                                   20


<210> 6453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAT

<400> 6453
gaaggaagat aaagtatcaa                                                   20


<210> 6454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6454
caactagaat tttacattca                                                   20


<210> 6455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6455
tggccagaag gcacttacta                                                   20


<210> 6456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6456
aaaggaggta cttcaggtag                                                   20


<210> 6457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 6457
aatatgtaat gtgtaatata                                                   20


<210> 6458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6458
aaactgtgct ccaaagggtt                                                   20


<210> 6459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6459
taggcttaca ggataccaga                                                   20


<210> 6460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6460
tcaaactgtg ttccaaagag                                                   20


<210> 6461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6461
ttttaggata gcagataggt                                                   20


<210> 6462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAT

<400> 6462
gatggccgac tggagtttgt                                                   20


<210> 6463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6463
tataacaaag gtataaagag                                                   20


<210> 6464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6464
ttgtacttat cttgagtaat                                                   20


<210> 6465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6465
ctatgttggt caagacagta                                                   20


<210> 6466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAT

<400> 6466
ggaaagattt agctggttta                                                   20


<210> 6467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6467
ttagctggtt tataagaata                                                   20


<210> 6468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6468
tagccactgt ttcttgtgca                                                   20


<210> 6469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6469
aggcatgggg aaaggaaagc                                                   20


<210> 6470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6470
gaacaattga gaactttgtc                                                   20


<210> 6471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6471
gcattaggct atgatacgag                                                   20


<210> 6472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6472
aatgtaaagt tgatttaaca                                                   20


<210> 6473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6473
caccacttta acagattgaa                                                   20


<210> 6474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 6474
acatgattat ctcaatacat                                                   20


<210> 6475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6475
tgaaaggatt ctttttggga                                                   20


<210> 6476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6476
agaacctaat ggcataagga                                                   20


<210> 6477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6477
atggcataag gattagaaaa                                                   20


<210> 6478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6478
cccgtctcta ctaaaaatac                                                   20


<210> 6479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 6479
ctactcagga ggctgaggca                                                   20


<210> 6480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6480
ctcaaaaaaa aaaaaaaaaa                                                   20


<210> 6481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6481
aaaaaaaaaa aaaaaaaaag                                                   20


<210> 6482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6482
aaaaaaaaaa agaaagaaaa                                                   20


<210> 6483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6483
tttcacatga tgtgattatg                                                   20


<210> 6484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 6484
aacattgtat agataaatta                                                   20


<210> 6485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6485
caaaatgcta gccaaaaatg                                                   20


<210> 6486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6486
gaagatatgc aagatcctat                                                   20


<210> 6487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6487
ccttgggata aaacggtaga                                                   20


<210> 6488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 6488
agtgcattga acacagagtt                                                   20


<210> 6489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6489
ctcaggtgca gacaaggtgg                                                   20


<210> 6490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6490
gagggaagtg gaatagatcc                                                   20


<210> 6491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAT

<400> 6491
ggacagggta gcattcccct                                                   20


<210> 6492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6492
cttctgcttc cccaagtgta                                                   20


<210> 6493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6493
gcgcccagcc tcgtatttta                                                   20


<210> 6494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6494
acatcaattt ctagatacct                                                   20


<210> 6495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6495
atttcgggca caagggaatc                                                   20


<210> 6496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6496
gcagataagg gagccaaggc                                                   20


<210> 6497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6497
ggagtttccc caagccatca                                                   20


<210> 6498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6498
ggcaatgata aaaatggcag                                                   20


<210> 6499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6499
gaaaatgtct tatttacaaa                                                   20


<210> 6500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 6500
ccagggtaac agtcaacgtg                                                   20


<210> 6501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 6501
ctctaattgt cttaaatagg                                                   20


<210> 6502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6502
atctgagccc ctcaccagcc                                                   20


<210> 6503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6503
caatgcatcc ttcttatgga                                                   20


<210> 6504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 6504
ttgcttccac ttttctaact                                                   20


<210> 6505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6505
aggtggctta attcaggggt                                                   20


<210> 6506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6506
tgatgtctaa actagatgcc                                                   20


<210> 6507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6507
aaggtagagg caactgagat                                                   20


<210> 6508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6508
gggatccgtc acaagcccaa                                                   20


<210> 6509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6509
gagccccagc cttgccctgc                                                   20


<210> 6510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6510
tgagctccct tttatttcac                                                   20


<210> 6511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 6511
tcttaccctt ataacatttg                                                   20


<210> 6512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6512
agatatcagc ctatgtgggc                                                   20


<210> 6513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6513
aaagcataat acattgtgaa                                                   20


<210> 6514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAA

<400> 6514
gcagatttat ttgtggtgat                                                   20


<210> 6515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6515
atatgcatag aacattgctt                                                   20


<210> 6516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6516
tgcacttgaa aaatcagttt                                                   20


<210> 6517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6517
ttttaatcac tgactggatt                                                   20


<210> 6518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6518
ttggcctttc tattctttct                                                   20


<210> 6519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6519
gaagatgatg tgccctatgc                                                   20


<210> 6520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6520
acaggctaaa aatctgaggc                                                   20


<210> 6521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAT

<400> 6521
cttgttgcta tctcattctt                                                   20


<210> 6522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6522
caaatttctg ttcttcttgg                                                   20


<210> 6523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6523
tcaacaaatg cttgttgata                                                   20


<210> 6524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CGAGAAT

<400> 6524
ggaggaagct taacagtttt                                                   20


<210> 6525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6525
caaaacaaac aaacaaaaac                                                   20


<210> 6526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6526
aaccaagaaa cctatctggc                                                   20


<210> 6527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6527
aagaaaccta tctggccaag                                                   20


<210> 6528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6528
tgatattaaa taattatcaa                                                   20


<210> 6529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6529
gagtctgtac acgttgttgt                                                   20


<210> 6530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6530
aaagcacaaa ctcaggtatg                                                   20


<210> 6531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 6531
cttgccacct ctggctttac                                                   20


<210> 6532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 6532
agtggattcc cacttgattg                                                   20


<210> 6533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6533
cagcataatg tgggcttgaa                                                   20


<210> 6534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAT

<400> 6534
agatggtggg gcctaagaca                                                   20


<210> 6535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6535
tcatctaagt attctgctga                                                   20


<210> 6536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6536
tataaacagt taataaacat                                                   20


<210> 6537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6537
tcatttaacc ctccagctat                                                   20


<210> 6538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAT

<400> 6538
tcactagcct ggtaatttaa                                                   20


<210> 6539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6539
ttaactagaa tgaatcaagg                                                   20


<210> 6540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6540
cacatgataa tctcaggaac                                                   20


<210> 6541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 6541
gagagggcaa atgaaaaaca                                                   20


<210> 6542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6542
gcttctattc agatctgtcc                                                   20


<210> 6543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6543
tttttctcat acctgtccaa                                                   20


<210> 6544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6544
tggggacaga gaagcactga                                                   20


<210> 6545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAT

<400> 6545
atataatttg catcactact                                                   20


<210> 6546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 6546
tctatgtctg taaaaaagga                                                   20


<210> 6547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 6547
gcgttttcca gaggcgaggc                                                   20


<210> 6548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6548
taggtatgca tggtggggaa                                                   20


<210> 6549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6549
ggttgcagcc taatttcctg                                                   20


<210> 6550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6550
ctgtgtggct taaagttgcc                                                   20


<210> 6551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6551
ttcataaacc cagagccctc                                                   20


<210> 6552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 6552
tattactaag ctactaaagt                                                   20


<210> 6553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6553
cttccaattt ttgaagcaaa                                                   20


<210> 6554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6554
tgagcaccaa gcaaaccaat                                                   20


<210> 6555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6555
caaaccaatg aagaaactga                                                   20


<210> 6556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 6556
ctccttggcc acgagttatt                                                   20


<210> 6557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 6557
atgtcttctg agtataagca                                                   20


<210> 6558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 6558
tgctaatctg tgtggggctg                                                   20


<210> 6559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6559
gctgctcaaa aggggcaaag                                                   20


<210> 6560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6560
agatattatc tgtcagacct                                                   20


<210> 6561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6561
tgcaaatttt agagtgggag                                                   20


<210> 6562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6562
agaaagttat tatgggggga                                                   20


<210> 6563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6563
gcaggacctt aggaaggagg                                                   20


<210> 6564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6564
ataaaaacca cctcgacgca                                                   20


<210> 6565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 6565
ccctcaatag gtcacttgca                                                   20


<210> 6566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6566
tcctcactta gcttcttctt                                                   20


<210> 6567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 6567
ggctagtcca gaacagtatc                                                   20


<210> 6568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAA

<400> 6568
gccaagatca agttgaccag                                                   20


<210> 6569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6569
ctgcaggttc aagggaaaga                                                   20


<210> 6570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6570
gggacgctaa tactttcacg                                                   20


<210> 6571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6571
acagataagg aatctggggg                                                   20


<210> 6572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6572
tgtcaatata tttattaaaa                                                   20


<210> 6573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAT

<400> 6573
agcaatgcct cgtttgaagt                                                   20


<210> 6574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAA

<400> 6574
gccttgtttc tatgtcttct                                                   20


<210> 6575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6575
ctgctctgga gccattgcct                                                   20


<210> 6576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6576
agcatcttta tgtctatgaa                                                   20


<210> 6577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6577
ttataggctg gatttggccc                                                   20


<210> 6578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAT

<400> 6578
tgttatgaat ctggcctctg                                                   20


<210> 6579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 6579
cttgtgaggg taatgtggct                                                   20


<210> 6580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 6580
ggactgcaac ttgctttagt                                                   20


<210> 6581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6581
ttgctttagt caagaatgta                                                   20


<210> 6582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 6582
ccagtccaaa atgctgatgc                                                   20


<210> 6583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6583
tatttatgta gatatctgct                                                   20


<210> 6584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6584
tagatatctg ctgaagaaag                                                   20


<210> 6585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6585
atctgctgaa gaaaggaaga                                                   20


<210> 6586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 6586
ctcaatctcc cccagcagag                                                   20


<210> 6587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 6587
gggatgctga gcaacaggaa                                                   20


<210> 6588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6588
agagagagag agagagagag                                                   20


<210> 6589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6589
agtgaaacaa aaatagacca                                                   20


<210> 6590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6590
aaacaaaaat agaccaagag                                                   20


<210> 6591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6591
aaatagacca agagaaagaa                                                   20


<210> 6592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6592
aaagaaaaag aaagagacac                                                   20


<210> 6593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6593
acagagaggt gagtttagca                                                   20


<210> 6594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6594
ttagcaatag aaagagacta                                                   20


<210> 6595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6595
ggagagcagc ttcgcaggta                                                   20


<210> 6596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6596
tctttccctg cagagccaga                                                   20


<210> 6597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAA

<400> 6597
gcagagccag acaagaaatg                                                   20


<210> 6598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAT

<400> 6598
tggtagaaaa gacttccact                                                   20


<210> 6599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6599
gggaagcatc aagtcccatt                                                   20


<210> 6600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 6600
gtttctgaat tctcagtaat                                                   20


<210> 6601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6601
gcctgaatcc cacaaccaga                                                   20


<210> 6602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6602
ataaatgctc acctgggatc                                                   20


<210> 6603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 6603
taacctgggg tatcattagc                                                   20


<210> 6604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAT

<400> 6604
atcattagcc tagaaaggat                                                   20


<210> 6605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 6605
aaaggatgca gaatggacac                                                   20


<210> 6606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6606
aacaggtggt gttgggttgc                                                   20


<210> 6607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 6607
ctattcctga gttacttcat                                                   20


<210> 6608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 6608
gccatttata tatcttcttt                                                   20


<210> 6609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAT

<400> 6609
agtttttcca atgttatctt                                                   20


<210> 6610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6610
gttgttattt ctatttctgt                                                   20


<210> 6611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAA

<400> 6611
agtgttttgt agttttcctt                                                   20


<210> 6612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6612
gacttccagt actatgttgg                                                   20


<210> 6613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 6613
aattcttctt tgaatgtctg                                                   20


<210> 6614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6614
tctatcacgt ggtctatctt                                                   20


<210> 6615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6615
aatattccat gtgctgatga                                                   20


<210> 6616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 6616
gtatattctg cagttgtttg                                                   20


<210> 6617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAT

<400> 6617
aaggtctgtt ttctctgata                                                   20


<210> 6618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 6618
ttaaggtttt atttcaagat                                                   20


<210> 6619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6619
ctggcttgca aggtttcagt                                                   20


<210> 6620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 6620
ttctttatat ctatttctct                                                   20


<210> 6621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAT

<400> 6621
aaccctcttt tgtcatatta                                                   20


<210> 6622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6622
tcatttgagt agactatttc                                                   20


<210> 6623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6623
caggctgtga gcttccccac                                                   20


<210> 6624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6624
ctgtgagctt ccccactgag                                                   20


<210> 6625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6625
tttgccccct ggattctgct                                                   20


<210> 6626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAT

<400> 6626
cacagttttt cacctgtctt                                                   20


<210> 6627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAA

<400> 6627
agacatatct gggaaggagg                                                   20


<210> 6628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6628
atgacctgct ctgactgctc                                                   20


<210> 6629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6629
tgctccaaga aaaaacatgc                                                   20


<210> 6630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6630
catctaaaaa ctcccagttt                                                   20


<210> 6631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6631
ggtaactgac agagcagacc                                                   20


<210> 6632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6632
gagggtgata agtagggctg                                                   20


<210> 6633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6633
gctttatgcc atccattcaa                                                   20


<210> 6634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6634
aatgagaaac tgtttctgct                                                   20


<210> 6635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6635
gcatactgaa aaatgcatat                                                   20


<210> 6636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6636
tttgaaggat gcttctaaca                                                   20


<210> 6637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6637
acaactgaaa aaaaaaaaaa                                                   20


<210> 6638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6638
tgaaaaaaaa aaaaaaaaga                                                   20


<210> 6639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6639
aaaaaaaaaa aaagaaaaga                                                   20


<210> 6640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6640
aaaaaaaaga aaagaaaaga                                                   20


<210> 6641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6641
aagagggcag aagaagagtt                                                   20


<210> 6642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 6642
ctactccgga ggctgaggcg                                                   20


<210> 6643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6643
acaggaagtg gaacaaaaaa                                                   20


<210> 6644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6644
tgataaaaag tttgaaaatt                                                   20


<210> 6645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 6645
ttgtttgact aataggaggt                                                   20


<210> 6646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6646
ttgactaata ggaggtctag                                                   20


<210> 6647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 6647
tagccaaact gtcaaagaag                                                   20


<210> 6648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6648
gaggatatgc tccattcaaa                                                   20


<210> 6649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6649
gaggcaaaag gaatccaaaa                                                   20


<210> 6650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6650
gaatccaaaa aaagaatgaa                                                   20


<210> 6651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 6651
gaatgaagaa gaaaaaatct                                                   20


<210> 6652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 6652
aaaacagctg tgcatcaggc                                                   20


<210> 6653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6653
aggcctagaa aacatctagg                                                   20


<210> 6654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6654
tgggaacaaa ttagggataa                                                   20


<210> 6655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6655
taggaagcca ataaataaca                                                   20


<210> 6656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6656
tggcctctgg aaagaagaga                                                   20


<210> 6657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6657
tgaaattgct gttttttttg                                                   20


<210> 6658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6658
tttttttcac atctgtgaga                                                   20


<210> 6659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6659
cactctttat gttttctaaa                                                   20


<210> 6660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6660
ctaaattaga aaatcttaac                                                   20


<210> 6661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6661
ttgtcaaatc aaacacagac                                                   20


<210> 6662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6662
aagtgctttt tctggtgaat                                                   20


<210> 6663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6663
ctgtgtacct caacagcaaa                                                   20


<210> 6664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6664
aaactttttt ataatcccga                                                   20


<210> 6665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6665
tgtcaatgtt gtggcatgta                                                   20


<210> 6666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6666
tttatcatta ttgttatgct                                                   20


<210> 6667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6667
gtttttgaaa acataaaaag                                                   20


<210> 6668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6668
gagatcctta gatcacttgt                                                   20


<210> 6669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAT

<400> 6669
aattgctctg ctaaacaaag                                                   20


<210> 6670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6670
atgatgaaag tctcaacaaa                                                   20


<210> 6671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAT

<400> 6671
ggaaaaataa aaaagtggta                                                   20


<210> 6672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6672
gtggtataag aatcataaag                                                   20


<210> 6673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6673
taggaagtcc aagggaatct                                                   20


<210> 6674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAA

<400> 6674
gctggatgca aaatcactat                                                   20


<210> 6675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAA

<400> 6675
ggaaaaagac attataaaat                                                   20


<210> 6676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6676
acaaagtttc cacagagttg                                                   20


<210> 6677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6677
ttaaactgat atggaaaagt                                                   20


<210> 6678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6678
atgtgacaat gagattactg                                                   20


<210> 6679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAA

<400> 6679
ggagattgaa atacctaaat                                                   20


<210> 6680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6680
aaggaaaact gtaactttga                                                   20


<210> 6681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6681
ttcacatgtt ctttgccagg                                                   20


<210> 6682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAT

<400> 6682
tataatttgt caaaggtttt                                                   20


<210> 6683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6683
ttcccaagca aaagagggga                                                   20


<210> 6684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6684
gcagacagat aggcaggcac                                                   20


<210> 6685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6685
attatcaatt tgcatttcaa                                                   20


<210> 6686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAT

<400> 6686
cagttaatac aaaatctcct                                                   20


<210> 6687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 6687
ttgacctggc aattctactt                                                   20


<210> 6688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 6688
tttatagttt gtcttttgtc                                                   20


<210> 6689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6689
aactctattt cattatgatc                                                   20


<210> 6690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6690
cccagcaaag ccattacatc                                                   20


<210> 6691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6691
tcagcaaatc gatgagatgc                                                   20


<210> 6692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6692
cctgcagctg gcattggtca                                                   20


<210> 6693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6693
acttccataa ccagcgggat                                                   20


<210> 6694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6694
tagactgggt ggcttatgca                                                   20


<210> 6695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6695
cttgtgttct cacacaaagg                                                   20


<210> 6696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 6696
ttgctgtaag ttttctcatt                                                   20


<210> 6697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6697
ttttctcatt ttagaatata                                                   20


<210> 6698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAT

<400> 6698
aggtacctaa gggtgtaata                                                   20


<210> 6699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAT

<400> 6699
tctttgattt aaaaaaaggt                                                   20


<210> 6700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6700
acgtgattat ctcaatagat                                                   20


<210> 6701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 6701
ctttgaaaac cagcacaaga                                                   20


<210> 6702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6702
ctggccaggg cgatcaggca                                                   20


<210> 6703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6703
ccagggcgat caggcaagag                                                   20


<210> 6704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6704
cagatgacat gactgtatat                                                   20


<210> 6705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6705
cccattcaca attgcaacaa                                                   20


<210> 6706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAA

<400> 6706
caacaaagag aataaaatat                                                   20


<210> 6707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 6707
agctaccact gactttcttc                                                   20


<210> 6708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6708
cactgacttt cttcacagaa                                                   20


<210> 6709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6709
aagacaattc taagcaaaaa                                                   20


<210> 6710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GCAGAAA

<400> 6710
ggaaaactgg ctagccttag                                                   20


<210> 6711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6711
ctaaaaccat aaaaacccta                                                   20


<210> 6712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6712
taaagagctt ctgcacagca                                                   20


<210> 6713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 6713
tcagagtgaa taggtaacct                                                   20


<210> 6714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6714
aataggtaac ctacagaatg                                                   20


<210> 6715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAT

<400> 6715
atctgacaaa gggctaatat                                                   20


<210> 6716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6716
aaaaaactta aacaaattta                                                   20


<210> 6717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6717
gctcatcatc actggtcatt                                                   20


<210> 6718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 6718
gagatggagt ctcataccag                                                   20


<210> 6719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6719
gattcctcaa ggatctagaa                                                   20


<210> 6720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6720
ccatcagtga tagactggat                                                   20


<210> 6721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6721
ctcagcaaac tgacataaga                                                   20


<210> 6722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6722
ctaggggagg gatagcatta                                                   20


<210> 6723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CTAGAAT

<400> 6723
caagtgaggt gttgatccac                                                   20


<210> 6724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 6724
atagtaaatc tcgacatcca                                                   20


<210> 6725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6725
atttcatgta aacttttgag                                                   20


<210> 6726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 6726
ctgttcttgt gttagtttgc                                                   20


<210> 6727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAT

<400> 6727
cccttctatt tcaacttttc                                                   20


<210> 6728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6728
aaaaaaaaaa aaaaaaaaaa                                                   20


<210> 6729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ATAGAAT

<400> 6729
tcacccacta acctagggaa                                                   20


<210> 6730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6730
acaaagactg ccaagtgaag                                                   20


<210> 6731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6731
gactgccaag tgaaggaaga                                                   20


<210> 6732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6732
aaatatctac attttgaagc                                                   20


<210> 6733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6733
tcttttttat tctaaaagac                                                   20


<210> 6734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6734
ttctaaaaga caaagaaaag                                                   20


<210> 6735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6735
gaaatgaaat actggctcag                                                   20


<210> 6736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 6736
gaactctgaa tagctagagt                                                   20


<210> 6737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6737
tggaagggga aaatagaagg                                                   20


<210> 6738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 6738
aagggaagaa atgttggtgg                                                   20


<210> 6739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6739
ctgctgactt acaattaaat                                                   20


<210> 6740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAT

<400> 6740
aacattcata gcaaatgtga                                                   20


<210> 6741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 6741
aaatattaat aatagggccc                                                   20


<210> 6742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6742
ctcatcaaat ctcaagatga                                                   20


<210> 6743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAT

<400> 6743
cttatccaga tgtaattcaa                                                   20


<210> 6744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAT

<400> 6744
caagcagaga cgacacattg                                                   20


<210> 6745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GTAGAAT

<400> 6745
ttgtcattaa atatccttct                                                   20


<210> 6746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6746
ctgaaaattc aagattcagc                                                   20


<210> 6747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6747
acgtaattct tgctggccag                                                   20


<210> 6748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AAAGAAA

<400> 6748
aattcttgct ggccagccag                                                   20


<210> 6749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6749
agaaagaaaa aaatgtaaaa                                                   20


<210> 6750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAA

<400> 6750
accagctcaa tgacaactgt                                                   20


<210> 6751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TAAGAAA

<400> 6751
tcttttttac tgaagccttc                                                   20


<210> 6752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAT

<400> 6752
aagcggacca cacaccgtgg                                                   20


<210> 6753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAA

<400> 6753
aatgtctgaa acaaaacaaa                                                   20


<210> 6754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6754
aacagaaagt ggacctccaa                                                   20


<210> 6755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6755
ctcttggcat gggagaggag                                                   20


<210> 6756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6756
ccagatatat gtatatcata                                                   20


<210> 6757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TTAGAAA

<400> 6757
gtgtgtatat atatctcata                                                   20


<210> 6758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6758
ttcaccaatg tatgatcata                                                   20


<210> 6759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAT

<400> 6759
ctggagaact ccagattatt                                                   20


<210> 6760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GGAGAAA

<400> 6760
gaccatattt cctagttcat                                                   20


<210> 6761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6761
tggcactcta tcttttgttt                                                   20


<210> 6762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: ACAGAAT

<400> 6762
gtgcctggaa ctaactagat                                                   20


<210> 6763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAA

<400> 6763
aaaactaaag aacattttgt                                                   20


<210> 6764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6764
tgtctttaat tcttcccttc                                                   20


<210> 6765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAT

<400> 6765
tcagttgttt agtaacaatg                                                   20


<210> 6766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CCAGAAT

<400> 6766
ggattgagaa caggactaag                                                   20


<210> 6767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TGAGAAA

<400> 6767
agtgtcttta catgacattc                                                   20


<210> 6768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: GAAGAAA

<400> 6768
gaggaaaagt aacataagaa                                                   20


<210> 6769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: TCAGAAT

<400> 6769
ctcttatggg caaactgggc                                                   20


<210> 6770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: AGAGAAA

<400> 6770
cagaacttac ttcagtggcc                                                   20


<210> 6771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNAGAAW;
      PAM sequence: CAAGAAA

<400> 6771
tggctgagga ggagacaatc                                                   20


<210> 6772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 6772
atagtccgta tgcctggcca                                                   20


<210> 6773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 6773
acaaaaccta aggttaccaa                                                   20


<210> 6774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 6774
tttaaatgga ctctgggaaa                                                   20


<210> 6775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 6775
aaagaaacaa atagaaaaga                                                   20


<210> 6776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 6776
acccgggata tagagacata                                                   20


<210> 6777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CGGGAT

<400> 6777
taataataat taaaaaaacc                                                   20


<210> 6778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 6778
ctaatgtaaa tgacaagtta                                                   20


<210> 6779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 6779
gtggggtgga gggagggggg                                                   20


<210> 6780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 6780
tcacacaccg gggacagttg                                                   20


<210> 6781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 6781
gcatgttctc actcataggt                                                   20


<210> 6782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 6782
ttcatgtcct ttgcagggac                                                   20


<210> 6783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 6783
ctatgcagcc ataaaaaatg                                                   20


<210> 6784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 6784
aatgtggcac atatacacca                                                   20


<210> 6785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 6785
aaatgtccaa cagtgataga                                                   20


<210> 6786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 6786
cattactggg tatataccca                                                   20


<210> 6787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 6787
ttgacccagc catcccatta                                                   20


<210> 6788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 6788
agtcggtgtg gcaattcctc                                                   20


<210> 6789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 6789
ggaacacttt tacactgttg                                                   20


<210> 6790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 6790
aggaaacaac aggtgctgga                                                   20


<210> 6791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 6791
agataccatc tcacaccagt                                                   20


<210> 6792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 6792
atcccatcaa aaagtgggcg                                                   20


<210> 6793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 6793
tctgacgaag ggctaatatc                                                   20


<210> 6794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 6794
tcagagtgaa cagaaaccta                                                   20


<210> 6795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 6795
gcagcaaaag aaaccaccat                                                   20


<210> 6796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 6796
caaaagtcaa aattgacaaa                                                   20


<210> 6797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 6797
tatacaaaaa ttaattcaag                                                   20


<210> 6798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 6798
ccatatggag aaagctgaaa                                                   20


<210> 6799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 6799
acaaaaacaa gaaatgggga                                                   20


<210> 6800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 6800
tctttgaagc aattgtgaat                                                   20


<210> 6801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 6801
ttattctctt tgaagcaatt                                                   20


<210> 6802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 6802
attcttccta cccatgagca                                                   20


<210> 6803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 6803
gtagcttgat ggggatggca                                                   20


<210> 6804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 6804
aaagtcattg gtagcttgat                                                   20


<210> 6805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 6805
ggttaaaaaa aaaacaggat                                                   20


<210> 6806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 6806
aagtaaggtt aaaaaaaaaa                                                   20


<210> 6807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 6807
tgccagtaac aaatcagaaa                                                   20


<210> 6808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 6808
agaatgaatg acttaattat                                                   20


<210> 6809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 6809
ttagactgtg taacttaaga                                                   20


<210> 6810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 6810
atcattagac tgtgtaactt                                                   20


<210> 6811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 6811
taaaattata ctttaaattc                                                   20


<210> 6812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 6812
aagtcacttt cctaagtgtt                                                   20


<210> 6813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 6813
ttcagaacat ccacttaaca                                                   20


<210> 6814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 6814
cactgaaggg agataagaga                                                   20


<210> 6815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 6815
atctctctgg cccagaatgt                                                   20


<210> 6816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 6816
aaactagaat ctctctggcc                                                   20


<210> 6817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 6817
ccacccacaa gaggtaaaac                                                   20


<210> 6818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CGGAGT

<400> 6818
tatacacatc ttgcatgaca                                                   20


<210> 6819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 6819
gtaatgggaa acattggaaa                                                   20


<210> 6820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 6820
atctagcctc agaagtgtaa                                                   20


<210> 6821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 6821
agagatacat gtgcaggcca                                                   20


<210> 6822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 6822
gaacagagac acacagagag                                                   20


<210> 6823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 6823
tggtgttgct aaaatatgag                                                   20


<210> 6824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 6824
ggttgaataa tgttccctaa                                                   20


<210> 6825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 6825
atgttgaatt atgctttggg                                                   20


<210> 6826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 6826
actttatgtt gaattatgct                                                   20


<210> 6827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 6827
gaacataatt caactttatg                                                   20


<210> 6828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 6828
aaaagtattt ttactttgag                                                   20


<210> 6829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 6829
ttctcaaaag tatttttact                                                   20


<210> 6830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 6830
atttttacaa tgatatgtga                                                   20


<210> 6831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 6831
ataagacagc taagtggaca                                                   20


<210> 6832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 6832
cttcaacgtc taaatcccat                                                   20


<210> 6833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 6833
tgcctgattt attctaaaag                                                   20


<210> 6834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 6834
catctcaaat cagctattct                                                   20


<210> 6835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 6835
gcaggttaat aagatgatga                                                   20


<210> 6836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 6836
aggctctcaa gatgcttact                                                   20


<210> 6837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 6837
tgatacatct cacatgcctc                                                   20


<210> 6838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 6838
cctataacaa cataggacat                                                   20


<210> 6839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 6839
aatggagtaa gaattgtcag                                                   20


<210> 6840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 6840
ttgtatgaac tgaatggagt                                                   20


<210> 6841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 6841
gattaattgt atgaactgaa                                                   20


<210> 6842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 6842
caaaagatta attgtatgaa                                                   20


<210> 6843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 6843
ccaagaacaa gagataaaat                                                   20


<210> 6844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 6844
agaagaaaaa gtataatcat                                                   20


<210> 6845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 6845
cataatcaga cattaaggag                                                   20


<210> 6846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 6846
ggcagctttt gaatacattc                                                   20


<210> 6847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 6847
tgtagctaaa gaggcagctt                                                   20


<210> 6848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 6848
attggtggga agggaagaaa                                                   20


<210> 6849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 6849
tgggatctgg aaatgccagt                                                   20


<210> 6850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 6850
agcaggaaag agcactgtcc                                                   20


<210> 6851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 6851
ttttcagttt gagattgagg                                                   20


<210> 6852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 6852
gtcacttacc cctcactttc                                                   20


<210> 6853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 6853
ctgtgatgct gacctgtatc                                                   20


<210> 6854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 6854
gtcggacaac tgctctgacc                                                   20


<210> 6855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 6855
cagagattgg caatattatt                                                   20


<210> 6856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 6856
ctgaatttca atatcagatc                                                   20


<210> 6857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 6857
cttccactgt gatttccctt                                                   20


<210> 6858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 6858
aaaaaccatc atacacaaat                                                   20


<210> 6859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 6859
cacaatgtca gaactgggca                                                   20


<210> 6860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 6860
cctagtgaga acactccagc                                                   20


<210> 6861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 6861
gtcactagag gccttagtga                                                   20


<210> 6862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 6862
catcattccc accgtcctat                                                   20


<210> 6863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 6863
tcctaggaga atccggggag                                                   20


<210> 6864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 6864
gaatgtccta ggagaatccg                                                   20


<210> 6865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 6865
tttcaccaag aatgtcctag                                                   20


<210> 6866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 6866
acatcctttt tgctttcacc                                                   20


<210> 6867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 6867
gacactctct ctggtcccct                                                   20


<210> 6868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 6868
cggaggagag cactgagccc                                                   20


<210> 6869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 6869
agattaccac gtcggccggc                                                   20


<210> 6870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 6870
agactgatcc gagcggccaa                                                   20


<210> 6871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CCGAAT

<400> 6871
ttcagagtca tccgcctggc                                                   20


<210> 6872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 6872
tacttctccc caacgctctt                                                   20


<210> 6873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 6873
gcagtctata ccaagcaaag                                                   20


<210> 6874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 6874
agggcccaga gtcctcaaat                                                   20


<210> 6875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 6875
catgccaggc tctgagggcc                                                   20


<210> 6876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 6876
ggcaaagata acatggtagg                                                   20


<210> 6877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 6877
tgactgtgga ggttgaccaa                                                   20


<210> 6878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 6878
ggccaaagac tgtgagcctg                                                   20


<210> 6879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 6879
gctgcagtat cagggaggag                                                   20


<210> 6880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 6880
gccttcacag agcacaggac                                                   20


<210> 6881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 6881
aggtagggag aggaatcata                                                   20


<210> 6882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 6882
tcacagtagg aggtagggag                                                   20


<210> 6883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 6883
acaggaccgg gtgccagaaa                                                   20


<210> 6884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CCGGGT

<400> 6884
ccgtacaatt agccacagga                                                   20


<210> 6885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CCGAAT

<400> 6885
tttagctgtc agccagttgc                                                   20


<210> 6886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 6886
tttccaactt tgttcatagt                                                   20


<210> 6887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 6887
tgtctggcag aaaattttac                                                   20


<210> 6888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 6888
ttcccaccaa caagaggtga                                                   20


<210> 6889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 6889
gtagcaccat ccgctggggc                                                   20


<210> 6890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 6890
ctaccagttc ctgtggctta                                                   20


<210> 6891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 6891
caagtactta gttctatgat                                                   20


<210> 6892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 6892
cttatctcac ttagcataat                                                   20


<210> 6893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 6893
ccattctatt ctctgctccc                                                   20


<210> 6894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 6894
ctatgctata agtagagctc                                                   20


<210> 6895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 6895
cctgcctatt tatttattta                                                   20


<210> 6896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 6896
tgtttaatgt acacaacttt                                                   20


<210> 6897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 6897
cttgggttgc gtgtatttcc                                                   20


<210> 6898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 6898
cttggtgctg aaacacagcc                                                   20


<210> 6899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 6899
ctgatttagt aacaagagct                                                   20


<210> 6900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CGGGGT

<400> 6900
gacctgctta cttttcatgt                                                   20


<210> 6901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 6901
aagagactgt ccctgggctt                                                   20


<210> 6902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 6902
agagtttcca agggttgaag                                                   20


<210> 6903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 6903
tgcagggtca cagagtttcc                                                   20


<210> 6904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 6904
aagaatatta tgcagggtca                                                   20


<210> 6905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 6905
cagagatcaa gaatattatg                                                   20


<210> 6906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 6906
aaaattgaga ctcagagatc                                                   20


<210> 6907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 6907
tgagcactga gctgggctcc                                                   20


<210> 6908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 6908
gggaaatgga gctgccttga                                                   20


<210> 6909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 6909
tggtgttcag agaaaattac                                                   20


<210> 6910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 6910
tgaatgacag gcccagtatt                                                   20


<210> 6911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 6911
aaggcccagt ctgggtgttg                                                   20


<210> 6912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 6912
taatactgtt aaggcccagt                                                   20


<210> 6913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 6913
caactgttct attagggaac                                                   20


<210> 6914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 6914
agattctcaa gtctagggtc                                                   20


<210> 6915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 6915
tcaaaggaga ttctcaagtc                                                   20


<210> 6916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 6916
aatctgttct ggaaaaggag                                                   20


<210> 6917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 6917
ggcaggtggt gtaatgtgag                                                   20


<210> 6918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 6918
aacctcagac cgtaagatga                                                   20


<210> 6919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 6919
tagaacctca ggggctgaca                                                   20


<210> 6920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 6920
ccctgtattt gcagctttcc                                                   20


<210> 6921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 6921
cacctctgtt tgggggtctt                                                   20


<210> 6922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 6922
gggaagcccc acctctgttt                                                   20


<210> 6923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GCGAGT

<400> 6923
ttgtggtggt tctctccatt                                                   20


<210> 6924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 6924
agtactactt cacaaatggc                                                   20


<210> 6925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GCGAAT

<400> 6925
ctttgtggcc gtcttcacag                                                   20


<210> 6926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 6926
tgttttctca gaacaagttc                                                   20


<210> 6927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 6927
atttcgcttc tgttaagatg                                                   20


<210> 6928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 6928
agtgaaattt tggaagaggt                                                   20


<210> 6929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 6929
cttgaactgg ggcaatgagg                                                   20


<210> 6930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 6930
agaggagata ggagggcatt                                                   20


<210> 6931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 6931
gatggattac tcaagactgt                                                   20


<210> 6932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 6932
gtaagtggag cttaaaagag                                                   20


<210> 6933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 6933
aagtgggatc cccaaaggga                                                   20


<210> 6934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 6934
actcgaggct gactgaaaag                                                   20


<210> 6935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 6935
ggaacagagg gaacatttcc                                                   20


<210> 6936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 6936
caaagcgtgg ggaatggggt                                                   20


<210> 6937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 6937
gaaggtcaaa gcgtggggaa                                                   20


<210> 6938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 6938
tgggagaagg tcaaagcgtg                                                   20


<210> 6939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 6939
gtaggggaga atggcagcct                                                   20


<210> 6940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 6940
ctgaggtaca tggggtaggg                                                   20


<210> 6941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 6941
ggcctaaccc ctgaggtaca                                                   20


<210> 6942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 6942
caggaagagc agtggtgtgg                                                   20


<210> 6943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 6943
ggcaaagctt caaagcaaga                                                   20


<210> 6944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 6944
attactgagg cagagggacc                                                   20


<210> 6945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 6945
tgttgcctag gataatagcc                                                   20


<210> 6946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 6946
acatggacat taatgttgcc                                                   20


<210> 6947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 6947
gtgcaataaa ccaagagaca                                                   20


<210> 6948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 6948
ctgttgatgt gggctgagga                                                   20


<210> 6949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 6949
agctctgttg atgtgggctg                                                   20


<210> 6950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 6950
ttagtgagaa caatctctgt                                                   20


<210> 6951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 6951
gcaatatcag acaagcgtcc                                                   20


<210> 6952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 6952
aaagcaacat ttcaaggtag                                                   20


<210> 6953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 6953
agaactctga tgtctaaaag                                                   20


<210> 6954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 6954
aaaaaatggg gtgaagagca                                                   20


<210> 6955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 6955
aattgtcaag ggagaaaaaa                                                   20


<210> 6956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 6956
acatatatgt taattcctgg                                                   20


<210> 6957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 6957
gccaggcact atgcagacac                                                   20


<210> 6958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 6958
gaattgaatt tagtcaaata                                                   20


<210> 6959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 6959
tatgtaccct tggtacagaa                                                   20


<210> 6960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 6960
ttcagtatgt acccttggta                                                   20


<210> 6961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 6961
gctcccgtgg gctccctgga                                                   20


<210> 6962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 6962
cccaccatga agcagaaggc                                                   20


<210> 6963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 6963
gattctttgc tctaacccaa                                                   20


<210> 6964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 6964
attttcagtg atgaaatgga                                                   20


<210> 6965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 6965
taattagaag tcatgtgacc                                                   20


<210> 6966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 6966
gctactccat tccctaaagt                                                   20


<210> 6967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 6967
tcatcgtctc tgagagcacc                                                   20


<210> 6968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 6968
tagaaatata ataggctcta                                                   20


<210> 6969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 6969
tttcttccat aggaaaagtt                                                   20


<210> 6970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 6970
gatttctgcc ccatcagtgc                                                   20


<210> 6971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 6971
ataccagcaa agcactgaca                                                   20


<210> 6972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 6972
tttggccaga ttattggccc                                                   20


<210> 6973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CCGGAT

<400> 6973
cacatgccca gtggcacaag                                                   20


<210> 6974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 6974
acagagaaat cagcacaaag                                                   20


<210> 6975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 6975
aaacaaaact ttgaagtggc                                                   20


<210> 6976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 6976
atcctttgaa tggaagaaga                                                   20


<210> 6977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 6977
ctccatcctt tgaatggaag                                                   20


<210> 6978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 6978
ttcctgagat tctccatcct                                                   20


<210> 6979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 6979
agctgcaact aagatcctcc                                                   20


<210> 6980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CGGAGT

<400> 6980
cagtaaatag gagtgggaga                                                   20


<210> 6981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 6981
tgaaattcca ggcagtaaat                                                   20


<210> 6982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 6982
tacttgtggc tggagtaaga                                                   20


<210> 6983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 6983
cactggcctt tacttgtggc                                                   20


<210> 6984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 6984
acttactgag aagcaagcag                                                   20


<210> 6985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 6985
gtcccaacca cattcaagtc                                                   20


<210> 6986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 6986
aattaaaatt aggtgaaagg                                                   20


<210> 6987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 6987
agcaaaagtc cttaggctca                                                   20


<210> 6988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 6988
tacaatcaag ataactggat                                                   20


<210> 6989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 6989
cacccataca atcaagataa                                                   20


<210> 6990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 6990
aagtattaca atggggagtg                                                   20


<210> 6991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 6991
tgataagaag tattacaatg                                                   20


<210> 6992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 6992
tgtattttga aatagtggtc                                                   20


<210> 6993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 6993
gattttttta aatcaaggta                                                   20


<210> 6994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 6994
aggaacaagc ctttccctaa                                                   20


<210> 6995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 6995
gagccatcca ctccagtgaa                                                   20


<210> 6996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 6996
tttctgagcc atccactcca                                                   20


<210> 6997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 6997
attattgttg atcgtcttca                                                   20


<210> 6998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 6998
gggaatggat gaacaggttt                                                   20


<210> 6999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 6999
aagatagcac ttttttggga                                                   20


<210> 7000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7000
ccctaagata gcactttttt                                                   20


<210> 7001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TCGAGT

<400> 7001
ggaaccaaaa gttatcccac                                                   20


<210> 7002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7002
caacaaccca actcccctgt                                                   20


<210> 7003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7003
agtaagggta gttagaaccc                                                   20


<210> 7004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7004
aggttaagct aagtgacagt                                                   20


<210> 7005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7005
acagttttag agttcaagta                                                   20


<210> 7006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 7006
ctgagtttct ccaacagttt                                                   20


<210> 7007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7007
tgaatctgtt gggggaagca                                                   20


<210> 7008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7008
accttttaca gctatttgaa                                                   20


<210> 7009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 7009
aagaagcaac tctggtcttc                                                   20


<210> 7010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7010
gatgagggtt cctaggccca                                                   20


<210> 7011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7011
gacgttggga tgagggtgat                                                   20


<210> 7012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7012
atctgggttg acgttgggat                                                   20


<210> 7013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7013
gagaagatct gggttgacgt                                                   20


<210> 7014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7014
ctgtttatgg aagagaagat                                                   20


<210> 7015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7015
tgtgtcaggc aggggcctga                                                   20


<210> 7016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 7016
tcctctagca cagcctgtct                                                   20


<210> 7017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 7017
ttctgatttt ggtatccgta                                                   20


<210> 7018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7018
tcagtcccac cgttccgaca                                                   20


<210> 7019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7019
ttgctttaga gacccaggca                                                   20


<210> 7020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7020
ccacccttta tccagcatct                                                   20


<210> 7021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 7021
aaccaacatg taccttctcc                                                   20


<210> 7022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7022
agaagcccaa agaattttac                                                   20


<210> 7023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7023
actgtgactc tagaagccca                                                   20


<210> 7024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7024
ttgagggctt ctgtccctcc                                                   20


<210> 7025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7025
ccctctgaga ccaaggaccc                                                   20


<210> 7026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7026
aggaagctaa aggtgagagt                                                   20


<210> 7027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 7027
tatgtcagga agctaaaggt                                                   20


<210> 7028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7028
gcatctactg aatccttggt                                                   20


<210> 7029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7029
tcactgagaa actgcatcta                                                   20


<210> 7030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 7030
agatgagcta gtgaccaggc                                                   20


<210> 7031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7031
ttctgagcat aagaagagga                                                   20


<210> 7032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 7032
acttacagga aatccttgcc                                                   20


<210> 7033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7033
ctggcactgt aacagcagag                                                   20


<210> 7034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 7034
ctactctctg gattgtggtg                                                   20


<210> 7035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7035
gggctaataa tacctactct                                                   20


<210> 7036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7036
tggcaatatt ttaaacccct                                                   20


<210> 7037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 7037
cattcctgac tcaactactt                                                   20


<210> 7038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7038
gtcacagagt acatgcaaac                                                   20


<210> 7039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7039
ggggctacat ggataagtca                                                   20


<210> 7040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7040
cccgagagaa aaggggctac                                                   20


<210> 7041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TCGAAT

<400> 7041
ccgactctga ttaataggaa                                                   20


<210> 7042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7042
gggtgccgac tctgattaat                                                   20


<210> 7043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7043
ggaggaaggc ttgtgcctcc                                                   20


<210> 7044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7044
ggcagaatcc caaccctcct                                                   20


<210> 7045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7045
aggccatggc ccagcactgg                                                   20


<210> 7046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7046
gatatgatcc ccacaaagga                                                   20


<210> 7047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 7047
tagaacttgc tgacctgttg                                                   20


<210> 7048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7048
gaatacaagc agggaaagaa                                                   20


<210> 7049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7049
gtgttccaag tgagccctgg                                                   20


<210> 7050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7050
actcaggatt cacatctcaa                                                   20


<210> 7051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7051
gccccactaa catcctcact                                                   20


<210> 7052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 7052
cctgtgattg ctgttgcagg                                                   20


<210> 7053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7053
aaaaaagata agtggtgctc                                                   20


<210> 7054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 7054
ttcacactga atctctttgt                                                   20


<210> 7055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7055
tttttggagg cttcttcaca                                                   20


<210> 7056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7056
catgtcttag gcttggcttt                                                   20


<210> 7057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 7057
actccctcat tcctgcttcc                                                   20


<210> 7058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 7058
agttactcag aggaccccag                                                   20


<210> 7059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 7059
ccaataagtt ttgggagtct                                                   20


<210> 7060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7060
aacccttacc aataagtttt                                                   20


<210> 7061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7061
caacttctcc cccaagtacc                                                   20


<210> 7062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7062
aggctgggga gacactattg                                                   20


<210> 7063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7063
tgctcgggag actgagacag                                                   20


<210> 7064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7064
tcaggaacta tcataaaacc                                                   20


<210> 7065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 7065
gtgcataggg aggaatgagg                                                   20


<210> 7066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7066
ctaaatcaag gtgcataggg                                                   20


<210> 7067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7067
gacaagggtg ggagcaaagc                                                   20


<210> 7068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7068
atgtgagcca ctccctggac                                                   20


<210> 7069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 7069
agtgtccagc tggctctctg                                                   20


<210> 7070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7070
cagctgttga ttcccgggag                                                   20


<210> 7071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7071
ctccaggcaa cctttaaagg                                                   20


<210> 7072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7072
tatagatgga tgggcagaca                                                   20


<210> 7073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7073
ttgggaaggg tccagtatag                                                   20


<210> 7074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7074
ctgggccacc atggcttggg                                                   20


<210> 7075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7075
tattcttaaa cagccacatg                                                   20


<210> 7076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7076
acacccagtt tctagacctc                                                   20


<210> 7077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7077
ttaagtgctg taacaggcct                                                   20


<210> 7078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 7078
tatgagaaac agactaatag                                                   20


<210> 7079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7079
atttattcaa caaataatct                                                   20


<210> 7080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 7080
catttgtcat gcagttactc                                                   20


<210> 7081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7081
tgccatggga ttatcaggtg                                                   20


<210> 7082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7082
ataaagggat gggcctgcca                                                   20


<210> 7083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7083
gggctagtag aatagcataa                                                   20


<210> 7084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 7084
attacacaag tgtgggctag                                                   20


<210> 7085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 7085
gaggctagag ggccttccta                                                   20


<210> 7086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7086
tgctatgtgg ggactttgca                                                   20


<210> 7087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 7087
tttggccgct caataaaatg                                                   20


<210> 7088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7088
accttgcact tctgcaggtg                                                   20


<210> 7089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 7089
tcaactttga taatgttgca                                                   20


<210> 7090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7090
aactccactg gcagcttctt                                                   20


<210> 7091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 7091
cccttgtacc tttgtcgatt                                                   20


<210> 7092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 7092
gtgcatcaac tataccgatg                                                   20


<210> 7093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 7093
tctggctcat cttcagcatc                                                   20


<210> 7094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7094
tgggcgccat cccatccatc                                                   20


<210> 7095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 7095
ctatctccca ccaggtggtg                                                   20


<210> 7096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 7096
aagagataga atccagcaga                                                   20


<210> 7097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 7097
tgaatgagta tagaaagaga                                                   20


<210> 7098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7098
tggctcatga agcagcctga                                                   20


<210> 7099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7099
ccactggctc atgaagcagc                                                   20


<210> 7100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7100
tgtctctcag tcttctgagt                                                   20


<210> 7101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7101
gcccaatgtc tctcagtctt                                                   20


<210> 7102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7102
tcttctcact gcaacccacc                                                   20


<210> 7103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7103
acacacactc acacttctaa                                                   20


<210> 7104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7104
ttttatgtat ggtatttaag                                                   20


<210> 7105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7105
aaataagcta ttttgtgaat                                                   20


<210> 7106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 7106
atttacaaat aagctatttt                                                   20


<210> 7107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7107
cctaactgcc tccgtcagga                                                   20


<210> 7108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7108
ttacctcagc tgccacccac                                                   20


<210> 7109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7109
agtctttcct ctaatactcc                                                   20


<210> 7110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7110
tctctgtctt tccatgacaa                                                   20


<210> 7111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7111
ttgctcttag tgaagtaatc                                                   20


<210> 7112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7112
cccacctcca aaggtaggct                                                   20


<210> 7113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7113
ttgtgccatt atactccagc                                                   20


<210> 7114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7114
cgggcggatc acctgaggtt                                                   20


<210> 7115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GCGGAT

<400> 7115
actttgggag gctgaggcgg                                                   20


<210> 7116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GCGGGT

<400> 7116
ctttctcgat ttgaaggcat                                                   20


<210> 7117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7117
aagtctcaca gcgaagattc                                                   20


<210> 7118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 7118
ggactgcctt tctggaaacc                                                   20


<210> 7119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7119
taggaatggg aggctgggca                                                   20


<210> 7120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7120
ggatgatggc ttagacgtgt                                                   20


<210> 7121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 7121
gttccgaata aggtgggagc                                                   20


<210> 7122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CCGAAT

<400> 7122
ctagacctct cattggagtt                                                   20


<210> 7123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 7123
actctttcta gacctctcat                                                   20


<210> 7124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 7124
ccagattgtt taagagagtg                                                   20


<210> 7125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 7125
ttcttgccca gattgtttaa                                                   20


<210> 7126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7126
gaggttggtg atgttagaga                                                   20


<210> 7127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 7127
ctgcccctag aaggaaaagg                                                   20


<210> 7128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7128
attcagatta ctatattcct                                                   20


<210> 7129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7129
caaaaaatca gggttcaaat                                                   20


<210> 7130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 7130
aacccaagct cacaaaaaat                                                   20


<210> 7131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7131
tctgactttt tcattttaca                                                   20


<210> 7132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7132
ctgcagagct atcagaactt                                                   20


<210> 7133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 7133
gtggctaaga tctcacagga                                                   20


<210> 7134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7134
actgccagga taagctgagc                                                   20


<210> 7135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7135
tgtgcatccc acctaactgc                                                   20


<210> 7136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7136
tgcaataagc cactcatcca                                                   20


<210> 7137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7137
gccttgcatg aatgaaggaa                                                   20


<210> 7138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7138
gctgatgtct ggagccttgc                                                   20


<210> 7139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7139
accctcatgc acccaggcag                                                   20


<210> 7140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 7140
gggctgagca aaagactgaa                                                   20


<210> 7141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7141
ccagggggct gagcaaaaga                                                   20


<210> 7142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 7142
cagtgggaat ggaggtgggc                                                   20


<210> 7143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7143
aggctagtgg gctgagcagt                                                   20


<210> 7144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7144
tcataatcag atttgcagtg                                                   20


<210> 7145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7145
ataaagtacc agtgatgttt                                                   20


<210> 7146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7146
cagagtatgg agtttatcct                                                   20


<210> 7147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 7147
atgacacagg ctacagagta                                                   20


<210> 7148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7148
tgaccatatg acacaggcta                                                   20


<210> 7149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 7149
atttgatttg ggtagaatgt                                                   20


<210> 7150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 7150
agggaacaat ttgatttggg                                                   20


<210> 7151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 7151
tgctcaggga acaatttgat                                                   20


<210> 7152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7152
actcttgggg tggggtggtt                                                   20


<210> 7153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 7153
gccttcttcc actcttgggg                                                   20


<210> 7154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 7154
catgagcctt cttccactct                                                   20


<210> 7155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 7155
gaaataaatg tattataagg                                                   20


<210> 7156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7156
catggaaata aatgtattat                                                   20


<210> 7157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7157
gaataaatac tcactatctc                                                   20


<210> 7158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7158
ctttgtaaga aacagaagca                                                   20


<210> 7159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7159
atacatctaa ctattgaata                                                   20


<210> 7160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7160
atttgctata catctaacta                                                   20


<210> 7161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7161
ccaaaccata tcaattttta                                                   20


<210> 7162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 7162
atgggaattc aagataagat                                                   20


<210> 7163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7163
cctcccctcc cacaacacat                                                   20


<210> 7164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 7164
catgattcac ttacctccca                                                   20


<210> 7165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 7165
aggtgcgagt cacgtcttat                                                   20


<210> 7166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GCGAGT

<400> 7166
atggcaaaag gaaaggaggt                                                   20


<210> 7167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 7167
tgaggcctga aatctgagtc                                                   20


<210> 7168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7168
ttagctgtga ggcctgaaat                                                   20


<210> 7169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7169
gcttcaggcc actgtaccac                                                   20


<210> 7170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7170
ttggtgcttg cctcctgaag                                                   20


<210> 7171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 7171
tagctgaggg tttctgcaag                                                   20


<210> 7172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7172
ctgttcactg ccgcatagct                                                   20


<210> 7173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7173
ttgctttgca gcatggttaa                                                   20


<210> 7174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7174
ggccagtaat ccctgcatta                                                   20


<210> 7175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 7175
catttggaga ggtaatgagc                                                   20


<210> 7176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 7176
agattctgat cttattggtc                                                   20


<210> 7177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7177
cctcacacct ggctgcactt                                                   20


<210> 7178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7178
agccatgaac tgtgagcaca                                                   20


<210> 7179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 7179
ttatggccct gcatccatag                                                   20


<210> 7180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7180
gacacaatag tgactgttag                                                   20


<210> 7181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7181
tgagaatagc cctgacaccc                                                   20


<210> 7182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7182
gagcatttag tgaggagtct                                                   20


<210> 7183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7183
aaagttttga gcatttagtg                                                   20


<210> 7184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 7184
cagtgggaac acgtggggtt                                                   20


<210> 7185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 7185
agtggctcag tgggaacacg                                                   20


<210> 7186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7186
tggacttcct cattgtgaat                                                   20


<210> 7187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 7187
gctggctgga cttcctcatt                                                   20


<210> 7188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 7188
gtgttcgaga tgctgcttaa                                                   20


<210> 7189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 7189
gctttgctgg agtacactga                                                   20


<210> 7190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 7190
gcccacggtg aaagctttgc                                                   20


<210> 7191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 7191
tcagtctggg ccccagtgct                                                   20


<210> 7192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7192
gggactgtgg tcagggctgg                                                   20


<210> 7193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 7193
ggccctgaag aagtcatgct                                                   20


<210> 7194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7194
aaacagcatc ttcttttaat                                                   20


<210> 7195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 7195
cccccacagc cacagcatcc                                                   20


<210> 7196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 7196
aaaaaaaaaa aaaaaaaaaa                                                   20


<210> 7197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7197
tacttgggag gctgaggcag                                                   20


<210> 7198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GCGGAT

<400> 7198
actttgggag gctgaggcgg                                                   20


<210> 7199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 7199
cactcctgcc agtcacttgt                                                   20


<210> 7200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7200
ttgctaggtt cctgaaacct                                                   20


<210> 7201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7201
ttaggattag tgcttgaagg                                                   20


<210> 7202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 7202
ccaacagcct ccagtgtcct                                                   20


<210> 7203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7203
actggcccct taaagaggac                                                   20


<210> 7204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7204
gccgacactc ccagcagatg                                                   20


<210> 7205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 7205
cccagcgaag ccatcaggaa                                                   20


<210> 7206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 7206
ctgagggctg ccccagcggg                                                   20


<210> 7207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 7207
atcggaagct gagaaaagat                                                   20


<210> 7208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7208
cttagtcctc gtcctagaca                                                   20


<210> 7209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 7209
tgtgtactcc cttagagacg                                                   20


<210> 7210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7210
atgtttactt ctaatacaca                                                   20


<210> 7211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 7211
gccttcttta ggctttcact                                                   20


<210> 7212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7212
ctcttctcct tccagtcctg                                                   20


<210> 7213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7213
gcagggactg gtctgccatc                                                   20


<210> 7214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 7214
gacgcaaagc caagggagaa                                                   20


<210> 7215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 7215
ctgagaggtg ggaggaaaac                                                   20


<210> 7216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7216
agcacaggtg cgggacgagg                                                   20


<210> 7217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7217
taaatgccag attgtccagg                                                   20


<210> 7218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 7218
agggctggga atagagagtt                                                   20


<210> 7219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 7219
tagttgaagg gctgggaata                                                   20


<210> 7220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7220
aggtaattag ttgaagggct                                                   20


<210> 7221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7221
agacatctct aaggccctgg                                                   20


<210> 7222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7222
gccttatggg aatagagatt                                                   20


<210> 7223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7223
tttgaataac aaggccttat                                                   20


<210> 7224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7224
tgccctcagt gacccacact                                                   20


<210> 7225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7225
ataaatctgt ggcagggcct                                                   20


<210> 7226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7226
ggctgcaagc atttgagtga                                                   20


<210> 7227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7227
acctggctgc aagcatttga                                                   20


<210> 7228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 7228
ccaaacctgg ctgcaagcat                                                   20


<210> 7229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 7229
aaggccctgg agctgcatca                                                   20


<210> 7230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7230
tgcccccaaa tcctccagat                                                   20


<210> 7231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 7231
cttcatgatc ctgctcagca                                                   20


<210> 7232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7232
tggataccac caagagtcca                                                   20


<210> 7233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 7233
gctgcaaact ggataccacc                                                   20


<210> 7234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7234
gccactgtcc ctgctgcaaa                                                   20


<210> 7235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7235
ccatcagtca cctctcccca                                                   20


<210> 7236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7236
atgacaagtg ggtttcctag                                                   20


<210> 7237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 7237
tttttccaag ggcatgacaa                                                   20


<210> 7238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7238
tcttcaccca tattccagga                                                   20


<210> 7239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7239
ggagaggaac acctgttggt                                                   20


<210> 7240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7240
gatatggcta ggaaaaacat                                                   20


<210> 7241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7241
ccactggtgt catctgtaag                                                   20


<210> 7242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 7242
aagaaaaatt ttttaaatac                                                   20


<210> 7243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7243
tcaagagtcc attctataaa                                                   20


<210> 7244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 7244
atttgtgcaa tgaatgaatc                                                   20


<210> 7245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7245
aataaatatt tgtgcaatga                                                   20


<210> 7246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7246
tctcaataaa tatttgtgca                                                   20


<210> 7247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 7247
tgagttctaa accagccctc                                                   20


<210> 7248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7248
ttaccctcaa aaacccctcc                                                   20


<210> 7249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7249
cagttgagcg aacactcacc                                                   20


<210> 7250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7250
acactgatgt taattagggc                                                   20


<210> 7251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7251
ccctgggctt ctcccctgca                                                   20


<210> 7252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ACGAGT

<400> 7252
tccccgggcc ccgcggagag                                                   20


<210> 7253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 7253
cagctggcga ggcaccaaac                                                   20


<210> 7254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 7254
agtgaatgct gagagtcgtt                                                   20


<210> 7255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 7255
attcaagccc agtgaatgct                                                   20


<210> 7256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 7256
tgattaaata ttcaagccca                                                   20


<210> 7257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7257
agagcaactt caacccctaa                                                   20


<210> 7258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 7258
atggggaccc gccccaccat                                                   20


<210> 7259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7259
atgttttcag tacacaactt                                                   20


<210> 7260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 7260
agggctgtca cattctgcac                                                   20


<210> 7261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7261
cagaagccgc ttggttccca                                                   20


<210> 7262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 7262
tgggacggga tttgggggct                                                   20


<210> 7263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CGGGAT

<400> 7263
gataagaggg agggctggga                                                   20


<210> 7264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 7264
ctaggcaagg ctgaccacag                                                   20


<210> 7265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7265
ttatcaagcc cttcagcttg                                                   20


<210> 7266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7266
tttaatttga cacctagcca                                                   20


<210> 7267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7267
aataacactg ccttcaattc                                                   20


<210> 7268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 7268
gagctggaag attagaggtt                                                   20


<210> 7269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7269
tagggagagg ctctctatag                                                   20


<210> 7270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 7270
atctttcaga gccagcaaat                                                   20


<210> 7271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 7271
gaatggtaat gcctacttgg                                                   20


<210> 7272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7272
ccatttattc atctatgaaa                                                   20


<210> 7273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 7273
tggttctagg tatagaaaga                                                   20


<210> 7274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 7274
ccattgccac aatctcactc                                                   20


<210> 7275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7275
ataacctcat ttcttatcct                                                   20


<210> 7276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 7276
ctggagggtg gcggtgaagg                                                   20


<210> 7277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7277
cagtgggctg gtagaggctg                                                   20


<210> 7278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7278
cctgggtgag acgtggaaag                                                   20


<210> 7279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7279
ctgaggacct ggctccatcc                                                   20


<210> 7280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7280
aaatttagaa ctggtcatct                                                   20


<210> 7281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7281
gtatgtatat atgtatgtac                                                   20


<210> 7282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7282
tcttataatt aatggagccc                                                   20


<210> 7283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7283
atatttagtc atcaaaacag                                                   20


<210> 7284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 7284
tggtccagaa aagctgtgct                                                   20


<210> 7285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7285
taatgagatt tctctaagaa                                                   20


<210> 7286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 7286
aaggccacct tgaggtgctt                                                   20


<210> 7287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7287
attccccagg cagacaaaca                                                   20


<210> 7288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7288
cagggcctgg aagaaaaagt                                                   20


<210> 7289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7289
aaccatgcca agctttccag                                                   20


<210> 7290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 7290
gtggggaggg gcttcagggc                                                   20


<210> 7291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 7291
gtgatcccca aaggacaggt                                                   20


<210> 7292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 7292
aatctgatct tgatgacttg                                                   20


<210> 7293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 7293
ctctgtgccc attgctgagg                                                   20


<210> 7294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7294
gggtctctgt gcccattgct                                                   20


<210> 7295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 7295
ttcatcgcta atccgactgt                                                   20


<210> 7296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7296
tccaagctcc cagaggcccc                                                   20


<210> 7297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ACGGAT

<400> 7297
aacctgcagg tggccctggc                                                   20


<210> 7298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CCGGGT

<400> 7298
cccccaaaag ggacagcatc                                                   20


<210> 7299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GCGGGT

<400> 7299
tccaagcctc gtccactgag                                                   20


<210> 7300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7300
agcccagggc tttggcacat                                                   20


<210> 7301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7301
gcaagatgtg cccaggattc                                                   20


<210> 7302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7302
tggaagcagc aagatgtgcc                                                   20


<210> 7303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7303
tccaccctgg tgcctgagcc                                                   20


<210> 7304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7304
ccaacttggg ttctttcctc                                                   20


<210> 7305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 7305
tgccctggac atcaaccaac                                                   20


<210> 7306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 7306
gggactgact ggttgtgtgg                                                   20


<210> 7307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 7307
tccacccact ctggtcatgg                                                   20


<210> 7308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 7308
ggctgcaggg agggggcaca                                                   20


<210> 7309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7309
cttactcatg ggtttactgg                                                   20


<210> 7310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 7310
caagaaaata atgcttactc                                                   20


<210> 7311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 7311
tctgctccac catttactag                                                   20


<210> 7312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 7312
tagaaaagaa agacctggtg                                                   20


<210> 7313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7313
tgggaggcag tctgacttgc                                                   20


<210> 7314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7314
tcaaactttt caaattcatg                                                   20


<210> 7315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7315
ctggggaaag gagaaggctt                                                   20


<210> 7316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7316
tggtgctagg gaacctggtg                                                   20


<210> 7317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 7317
ttccgtatcc tctgtggaga                                                   20


<210> 7318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 7318
tgtcttccgt atcctctgtg                                                   20


<210> 7319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7319
cagaaaacgc cctggtttaa                                                   20


<210> 7320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 7320
atagaaggca gatcatattt                                                   20


<210> 7321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7321
tcaggcctgt ggctatagaa                                                   20


<210> 7322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7322
agaagaggcc catattcagg                                                   20


<210> 7323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 7323
gccaatacct atcgaatgca                                                   20


<210> 7324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TCGAAT

<400> 7324
agatgttttg ccaataccta                                                   20


<210> 7325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7325
attaaatcaa cttatgaatg                                                   20


<210> 7326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7326
ttggtcaatt aaatcaactt                                                   20


<210> 7327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 7327
cctgcacggc tggagttctg                                                   20


<210> 7328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 7328
ctgccatgca cctgcacggc                                                   20


<210> 7329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 7329
tcttgtggga cttagcatat                                                   20


<210> 7330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 7330
cgtgggattt actcacggat                                                   20


<210> 7331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ACGGAT

<400> 7331
tcctcccgtg ggatttactc                                                   20


<210> 7332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7332
caggattaaa cctcctcccg                                                   20


<210> 7333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7333
atacagcact tactgtataa                                                   20


<210> 7334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 7334
tgaggagagt aacttccaga                                                   20


<210> 7335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 7335
agctctgctt cccatatgag                                                   20


<210> 7336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7336
ctgcctctgt gaccagtcca                                                   20


<210> 7337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7337
acatgaaggg tatagctctt                                                   20


<210> 7338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7338
ttgtggttca tccttacatg                                                   20


<210> 7339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7339
caattttcct tgcattctcc                                                   20


<210> 7340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 7340
acttaaaata cctaggtagt                                                   20


<210> 7341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 7341
taattctgca gagcactttg                                                   20


<210> 7342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7342
aactcttaaa caatttttga                                                   20


<210> 7343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7343
aattctatca tctgaagaaa                                                   20


<210> 7344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 7344
gtattatatt tttcatttct                                                   20


<210> 7345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7345
atgtctctct aggttacatt                                                   20


<210> 7346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7346
gcttaagata tactgacttc                                                   20


<210> 7347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7347
taactgttat tccttccttt                                                   20


<210> 7348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7348
gtctttgaga gacatttctt                                                   20


<210> 7349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 7349
tctacctgaa gtacctcctt                                                   20


<210> 7350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7350
tacacattac atattacttc                                                   20


<210> 7351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7351
gtttgagttt cagattttca                                                   20


<210> 7352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 7352
cttactcttt ggaacacagt                                                   20


<210> 7353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7353
atctgctatc ctaaaaactc                                                   20


<210> 7354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7354
ttcatcatca cacaagggga                                                   20


<210> 7355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7355
gttgcatatg caaatctggg                                                   20


<210> 7356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 7356
ttatctcttc atgcttactc                                                   20


<210> 7357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 7357
ggaaggaaag gggaggtttg                                                   20


<210> 7358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CGGGAT

<400> 7358
aatgtttagt gggtggatac                                                   20


<210> 7359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 7359
tattagaaaa tgtttagtgg                                                   20


<210> 7360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 7360
tttttattag aaaatgttta                                                   20


<210> 7361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 7361
ttgtgtctgg gaggagaaaa                                                   20


<210> 7362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 7362
aaagggaaag aaaaagttca                                                   20


<210> 7363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 7363
caagtagcgc ctcaaggatc                                                   20


<210> 7364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7364
tctacttcaa gtagcgcctc                                                   20


<210> 7365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7365
gcttgttggg aagctctcct                                                   20


<210> 7366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7366
cagtgatacc ctctaaatct                                                   20


<210> 7367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7367
tgccagcaat atttttgtca                                                   20


<210> 7368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 7368
ggtttaataa acccttcccc                                                   20


<210> 7369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7369
atcgtcaagg ctctaaactt                                                   20


<210> 7370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7370
taatcccatt gctcactgcc                                                   20


<210> 7371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 7371
ccattactac aagctttgct                                                   20


<210> 7372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7372
agtgaaaggc tttttcagtc                                                   20


<210> 7373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7373
tatacagaca atctctaaaa                                                   20


<210> 7374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 7374
tatttgggag gctgaggtgg                                                   20


<210> 7375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7375
tacttgggag gctgagggag                                                   20


<210> 7376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7376
caggcggatc acctgaggtc                                                   20


<210> 7377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GCGGAT

<400> 7377
actgttggag gcgcaggcag                                                   20


<210> 7378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7378
gggtgaggca tgagaattgc                                                   20


<210> 7379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7379
tactcaggag ggtgaggcat                                                   20


<210> 7380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7380
ctgtaatccc agctactcag                                                   20


<210> 7381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7381
actaaaaata tataaattag                                                   20


<210> 7382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7382
tgggaggatt gcttgaggac                                                   20


<210> 7383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 7383
attttgggag gccaaggtgg                                                   20


<210> 7384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7384
gtggctcacg cctgtaatcc                                                   20


<210> 7385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 7385
ttaaagccaa gggggccagg                                                   20


<210> 7386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7386
agattttttt atccatatca                                                   20


<210> 7387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 7387
tccttcaatc tgttaaagtg                                                   20


<210> 7388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7388
atcaagaata tttatcatga                                                   20


<210> 7389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7389
ttttatcaag aatatttatc                                                   20


<210> 7390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7390
tcaggaagtt ctcttttatc                                                   20


<210> 7391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7391
atcaattttc tgatcccaaa                                                   20


<210> 7392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7392
gccttggcct cctaaagtgc                                                   20


<210> 7393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7393
cggggtttca ccgtgttagc                                                   20


<210> 7394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CGGGGT

<400> 7394
ctttgtattt ttagtagaga                                                   20


<210> 7395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7395
cattctcctg cctcagcctc                                                   20


<210> 7396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CCGGGT

<400> 7396
ctcattgcca gctccacctc                                                   20


<210> 7397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 7397
tctcgctctg tcacccaggc                                                   20


<210> 7398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7398
tttttttttt ttttttgaga                                                   20


<210> 7399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7399
cacatcatgt gaaaataaca                                                   20


<210> 7400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 7400
ggtttttata attttctcca                                                   20


<210> 7401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 7401
gcacactttc atattcactt                                                   20


<210> 7402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7402
taatccacct aatttacttc                                                   20


<210> 7403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7403
ctatcccatg aggcaaaaac                                                   20


<210> 7404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 7404
cccaaccaca ctatctaaag                                                   20


<210> 7405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7405
gaagtttttt tcgctgtgcc                                                   20


<210> 7406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7406
cactggtttc ccattgctct                                                   20


<210> 7407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7407
cacacacaca cacacacaca                                                   20


<210> 7408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 7408
tgtttgccaa aacctcaccg                                                   20


<210> 7409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7409
ccaccaacta cacactttct                                                   20


<210> 7410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7410
gcccctacag gattctgcag                                                   20


<210> 7411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7411
tacttcacag tctgccccta                                                   20


<210> 7412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7412
tactcgggag gctgaggcag                                                   20


<210> 7413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GCGGAT

<400> 7413
actttgggag gccgaggcag                                                   20


<210> 7414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7414
acttgaaaat cttacaaggt                                                   20


<210> 7415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 7415
catcccaggg aggagaaggg                                                   20


<210> 7416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7416
gtcaccatcc cagggaggag                                                   20


<210> 7417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7417
tatggcctgt ccattattgt                                                   20


<210> 7418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7418
gaaaggagac acagagagag                                                   20


<210> 7419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7419
ctgcactcca gcctgggaga                                                   20


<210> 7420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 7420
tactcagaag actgaggtgg                                                   20


<210> 7421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7421
caggcagatc gcttgagccc                                                   20


<210> 7422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7422
agcagtgcac aactcctggg                                                   20


<210> 7423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7423
ccatggaaga gatgtgggca                                                   20


<210> 7424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 7424
gaacttggcg tacctggatt                                                   20


<210> 7425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7425
agcccctgaa cttggcgtac                                                   20


<210> 7426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 7426
gttggcatcc agaggttgaa                                                   20


<210> 7427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7427
agagaggtga caaaacaaag                                                   20


<210> 7428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7428
agcgcaggcc gcctgctctc                                                   20


<210> 7429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7429
ttggcatctc actgactctt                                                   20


<210> 7430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TCGGGT

<400> 7430
ctgtcagatt cccaggagtg                                                   20


<210> 7431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7431
gccaaacctg tcagattccc                                                   20


<210> 7432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7432
caagcgaata agccacagac                                                   20


<210> 7433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GCGAAT

<400> 7433
gtctcccatc tgccaagcaa                                                   20


<210> 7434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7434
ctcaggggtg ggtgaggaaa                                                   20


<210> 7435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 7435
cgtttttaag atcctcaggg                                                   20


<210> 7436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 7436
tagtcgtttt taagatcctc                                                   20


<210> 7437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7437
gccccagctt ttcgctgact                                                   20


<210> 7438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 7438
actcctgggc gactggagac                                                   20


<210> 7439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 7439
cctgtccttg tgggagggag                                                   20


<210> 7440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7440
ttgactgcat catcgtcact                                                   20


<210> 7441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7441
actattattt ccagaagaag                                                   20


<210> 7442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7442
atagcaactg aacaaaacaa                                                   20


<210> 7443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7443
ctgcagcatg cacagcccct                                                   20


<210> 7444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7444
aagctaggaa atgtctgggc                                                   20


<210> 7445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7445
tgaggaaatt gaggtacagg                                                   20


<210> 7446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7446
ctagtcactg ttacttatga                                                   20


<210> 7447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7447
cttactagtc actgttactt                                                   20


<210> 7448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7448
ctaaaagaat cttagaggca                                                   20


<210> 7449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7449
tagagacaca cagagcctaa                                                   20


<210> 7450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7450
gttctgacct ctctcagtgt                                                   20


<210> 7451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7451
cctgttttct tctccataag                                                   20


<210> 7452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7452
ggacactcca tagatactct                                                   20


<210> 7453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 7453
atagctggtg agggtggatc                                                   20


<210> 7454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 7454
aaattgtata gctggtgagg                                                   20


<210> 7455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7455
cccaaaattg tatagctggt                                                   20


<210> 7456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7456
tgcaatgagt caggtgcttt                                                   20


<210> 7457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7457
tcatgtgctt ggtgcctgca                                                   20


<210> 7458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7458
taagaccaca gagggcctta                                                   20


<210> 7459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7459
aaggaaaaat ggaaagagaa                                                   20


<210> 7460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7460
cagtaggttc tggaacatgg                                                   20


<210> 7461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 7461
tcaccagaac tgtctggctt                                                   20


<210> 7462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7462
accaagctgg aggtgaccta                                                   20


<210> 7463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 7463
tcctgccttc atgtccgcag                                                   20


<210> 7464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7464
catgataggc agaagctaga                                                   20


<210> 7465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7465
aagcccgctt ttcttaaccc                                                   20


<210> 7466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7466
gttgagttta gtggccacat                                                   20


<210> 7467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 7467
atcttcccaa gatcatagag                                                   20


<210> 7468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 7468
aaataatctt cccaagatca                                                   20


<210> 7469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7469
ataatactca gatgcttctc                                                   20


<210> 7470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7470
tccaaccttg ccccacccac                                                   20


<210> 7471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7471
atactggatt tcactatata                                                   20


<210> 7472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7472
ttaacaagat acaatccata                                                   20


<210> 7473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 7473
tgttgtcact taaggagaaa                                                   20


<210> 7474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 7474
agttgcctct accttgaaat                                                   20


<210> 7475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7475
aggacaacca cttgaatttt                                                   20


<210> 7476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7476
acaaaacata ggacaaccac                                                   20


<210> 7477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7477
tgagctggtg ggaatggctt                                                   20


<210> 7478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7478
aggacccagg ctgagctggt                                                   20


<210> 7479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7479
gtgcaggaga catgtggaca                                                   20


<210> 7480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 7480
atggcagggt gcagttcggg                                                   20


<210> 7481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TCGGGT

<400> 7481
ggatgatggc agggtgcagt                                                   20


<210> 7482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 7482
gggcggggtg gggatgatgg                                                   20


<210> 7483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 7483
tggcgtggtc ggggcggggt                                                   20


<210> 7484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CGGGGT

<400> 7484
cctcactggc gtggtcgggg                                                   20


<210> 7485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7485
tgctccagat aggcaacatc                                                   20


<210> 7486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ACGGAT

<400> 7486
caattctctt tgggcttgtg                                                   20


<210> 7487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 7487
atctgggatt gctgccccat                                                   20


<210> 7488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7488
tgtctcagaa gtatctgatc                                                   20


<210> 7489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7489
acactataat gcagaactcg                                                   20


<210> 7490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 7490
ctagaggatg accgcagaat                                                   20


<210> 7491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7491
caaggtctag aggatgaccg                                                   20


<210> 7492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 7492
attattaaca acaaggtcta                                                   20


<210> 7493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7493
aggagttcaa aatataggaa                                                   20


<210> 7494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7494
aattggagtt gcaggactaa                                                   20


<210> 7495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 7495
tggatggggc agatattaat                                                   20


<210> 7496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7496
aatgtcagca gtttaaagga                                                   20


<210> 7497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7497
acaagggagt agttagagag                                                   20


<210> 7498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7498
ggaattgagg gtgcctacaa                                                   20


<210> 7499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7499
aggagagggg caaaggaatt                                                   20


<210> 7500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7500
atgaaggagg agaggggcaa                                                   20


<210> 7501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 7501
agtacagagt agtctacaaa                                                   20


<210> 7502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7502
cagctggttg ggtgcaagta                                                   20


<210> 7503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 7503
ttccagccag gtccagctgg                                                   20


<210> 7504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7504
tggggctcac agatctctag                                                   20


<210> 7505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7505
catctggaag aatgaaggaa                                                   20


<210> 7506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7506
acagtcatct ggaagaatga                                                   20


<210> 7507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7507
agtgagaaac agtcatctgg                                                   20


<210> 7508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 7508
taaaagggag ctcatcaaca                                                   20


<210> 7509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7509
tttgtgaact agtctatatt                                                   20


<210> 7510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7510
cactgtgtgg ggcacgaaga                                                   20


<210> 7511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 7511
aagagcccgg cacaagtggg                                                   20


<210> 7512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7512
aggtctggat gatgcaggcc                                                   20


<210> 7513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7513
ggtctggaag ggagacaggt                                                   20


<210> 7514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 7514
agcagtaatg aaagagagca                                                   20


<210> 7515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7515
aagtgtagaa aactcttgca                                                   20


<210> 7516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7516
gagaactgga aatcaattat                                                   20


<210> 7517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7517
taaattctgt caaatgttat                                                   20


<210> 7518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 7518
agaagctaag gtgagaatgc                                                   20


<210> 7519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7519
aaacacagag aagctaaggt                                                   20


<210> 7520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7520
aattggacac ataatttggt                                                   20


<210> 7521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7521
gataagccta gtgttcagga                                                   20


<210> 7522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7522
tcaagatgca tgtcttgccg                                                   20


<210> 7523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7523
gggattgttg attttggtcc                                                   20


<210> 7524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7524
ttcttgcttt tgttccaaac                                                   20


<210> 7525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7525
ggggacctct ttaagcgtaa                                                   20


<210> 7526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7526
agactcctgc agtggcagga                                                   20


<210> 7527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7527
gactgaagat taagggaaga                                                   20


<210> 7528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7528
tgctaatggg aaggatctgg                                                   20


<210> 7529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7529
catatttgca tgctaatggg                                                   20


<210> 7530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7530
tttttggttt ttgtgtttgg                                                   20


<210> 7531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7531
agatggcact agggagtagg                                                   20


<210> 7532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7532
gagatagtaa gatggcacta                                                   20


<210> 7533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GCGGGT

<400> 7533
atattgaagg ggcttaaaga                                                   20


<210> 7534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7534
aaagaggatt aatggagtaa                                                   20


<210> 7535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 7535
tctaagcaaa agaggattaa                                                   20


<210> 7536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 7536
ctttggtgat ctaagcaaaa                                                   20


<210> 7537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7537
ggtccagggg ctttagtcac                                                   20


<210> 7538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7538
agagtaaaaa tttcttcaga                                                   20


<210> 7539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 7539
gaagaataca atgcagagcc                                                   20


<210> 7540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7540
agaaatagga aaagatctag                                                   20


<210> 7541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7541
aactggatga gttaacacag                                                   20


<210> 7542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7542
ttttgaaaag atgcaactgg                                                   20


<210> 7543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7543
gtaattttga aaagatgcaa                                                   20


<210> 7544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7544
tatatatatt tgaaagcagt                                                   20


<210> 7545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 7545
ggaagttgac tttaggatat                                                   20


<210> 7546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 7546
gtccagtagg aagttgactt                                                   20


<210> 7547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 7547
tgcccttgga gcatctaggt                                                   20


<210> 7548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 7548
tgagttgagt ctgggatata                                                   20


<210> 7549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7549
agaagattat gagttgagtc                                                   20


<210> 7550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 7550
agatgaaaga agattatgag                                                   20


<210> 7551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7551
gggaaagatg aaagaagatt                                                   20


<210> 7552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7552
gtggggctga tgggaaatgg                                                   20


<210> 7553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 7553
agatggcagt gcttgaactc                                                   20


<210> 7554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7554
tgcattttat aaaagttact                                                   20


<210> 7555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7555
agaggagtga ggtgccatta                                                   20


<210> 7556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7556
atatgggact tcatgctaag                                                   20


<210> 7557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7557
agaaactcct agactgcatt                                                   20


<210> 7558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7558
ctgaaaataa ggctagaggg                                                   20


<210> 7559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7559
agaactgaaa ataaggctag                                                   20


<210> 7560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7560
gaagagagaa taacatttga                                                   20


<210> 7561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7561
aaggactgca aagcagaaga                                                   20


<210> 7562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7562
gtaagatttg cctggagcca                                                   20


<210> 7563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7563
agtgccttaa agaggaagtg                                                   20


<210> 7564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7564
gcagtgagct tactggagtg                                                   20


<210> 7565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 7565
ggtcacagca gtgagcttac                                                   20


<210> 7566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7566
ccaagccaga attccagaag                                                   20


<210> 7567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7567
gatttcactg ttgtccaagc                                                   20


<210> 7568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7568
aaagtttggc ccaaaccaac                                                   20


<210> 7569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7569
ataaaggcca cctctttaag                                                   20


<210> 7570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 7570
tcatgctgcc agagtcgtaa                                                   20


<210> 7571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7571
tgaaggatgc ttcatgctgc                                                   20


<210> 7572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7572
ttacacacat gagacacctg                                                   20


<210> 7573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 7573
gggcacatca tcttctctgg                                                   20


<210> 7574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 7574
caaggaagat gctgtgacag                                                   20


<210> 7575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 7575
aataggcaaa tatgttgggg                                                   20


<210> 7576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 7576
taagtaatag gcaaatatgt                                                   20


<210> 7577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7577
atatttgggt ggttggcggc                                                   20


<210> 7578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 7578
tgcatgcaca aaggtgatat                                                   20


<210> 7579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7579
tagagttttg tgaggattaa                                                   20


<210> 7580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 7580
cttatcttgt agagttttgt                                                   20


<210> 7581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 7581
gtgagaatat acttatcttg                                                   20


<210> 7582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7582
tttttagcct gtaaagtagt                                                   20


<210> 7583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7583
ctgctctgga acccggctgc                                                   20


<210> 7584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7584
gggatgaatg agaggcaaca                                                   20


<210> 7585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7585
agacaaaaga aggtcatggg                                                   20


<210> 7586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7586
ggtaagacaa aagaaggtca                                                   20


<210> 7587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7587
gcaagtacaa tgcattctgc                                                   20


<210> 7588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7588
cagaaatttg aattaaataa                                                   20


<210> 7589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7589
tctccaagaa gaacagaaat                                                   20


<210> 7590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7590
cagggaaggg gacatgaaag                                                   20


<210> 7591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7591
ctgatataag cttgcgctca                                                   20


<210> 7592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7592
tgtggcattg cttcaggtgc                                                   20


<210> 7593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7593
tagtcatcaa acagcaaaca                                                   20


<210> 7594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 7594
ttctaacatt tttcatggca                                                   20


<210> 7595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 7595
aatatcactg ttcattgtaa                                                   20


<210> 7596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7596
aagttacatt tcttgcatac                                                   20


<210> 7597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7597
gtgaggactt gaagcataaa                                                   20


<210> 7598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7598
agtgaaggct atggaaaaag                                                   20


<210> 7599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7599
tccagaatgg cagagaggag                                                   20


<210> 7600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7600
cagagagagc cctgtggctc                                                   20


<210> 7601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 7601
caaggaagat actgtgagag                                                   20


<210> 7602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 7602
ccgctcaagg aagatactgt                                                   20


<210> 7603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 7603
aatagtcagg tatcttgggg                                                   20


<210> 7604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 7604
taaggaatag tcaggtatct                                                   20


<210> 7605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7605
tgataaaaag gaagaaaata                                                   20


<210> 7606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 7606
attaacaaag gtgatatctg                                                   20


<210> 7607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7607
tgtatctgtt ttgctcacag                                                   20


<210> 7608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 7608
attcacatgc acagaaactg                                                   20


<210> 7609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7609
agaaaccaaa aaaatgtttg                                                   20


<210> 7610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7610
gttttcctcc cagccctagg                                                   20


<210> 7611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7611
gtgctggtgt gcccctgaga                                                   20


<210> 7612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 7612
tggaggagtt gtaagggagc                                                   20


<210> 7613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7613
attaaactga cctaggctgg                                                   20


<210> 7614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7614
tttttttgcc ttagggtatg                                                   20


<210> 7615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 7615
aatccagcct ttttttgcct                                                   20


<210> 7616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 7616
caagccaaag ggtagaggaa                                                   20


<210> 7617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7617
tgtatctaag ttccaagcca                                                   20


<210> 7618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7618
tagaattcta ccaatcaagt                                                   20


<210> 7619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 7619
taactaagtc cttgttaatt                                                   20


<210> 7620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7620
ttgttcaagc ccacattatg                                                   20


<210> 7621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7621
aagtgatctg gcaggcatca                                                   20


<210> 7622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7622
ttcaaaaaca aaataatttg                                                   20


<210> 7623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7623
aagcgtccat ctctgtgtac                                                   20


<210> 7624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7624
tgttcatcca ctgtgtcatg                                                   20


<210> 7625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7625
gtatcataac ctccgtcctt                                                   20


<210> 7626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7626
ctttccgggc ccaaagggca                                                   20


<210> 7627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7627
aaagaagact ttcttgtcag                                                   20


<210> 7628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7628
tgagattggc caataagagg                                                   20


<210> 7629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7629
aatacaatgt aggatattca                                                   20


<210> 7630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 7630
ttgtttgtgt aaatacaatg                                                   20


<210> 7631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7631
aaaaggtttc taaatagctg                                                   20


<210> 7632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7632
ccaactgtgc cagttaccac                                                   20


<210> 7633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7633
ggcatcctgc agggctcgct                                                   20


<210> 7634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7634
gagtaggtct ccagggcaaa                                                   20


<210> 7635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 7635
cagagacagt ggagaaggta                                                   20


<210> 7636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7636
cctggccaga accagagggt                                                   20


<210> 7637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7637
accaaacctg gccagaacca                                                   20


<210> 7638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7638
acttgtctct ccttctatcc                                                   20


<210> 7639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 7639
cagaacttgt gatcttagta                                                   20


<210> 7640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7640
gaagggatga aggaaaggac                                                   20


<210> 7641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7641
ctgttacatg cctaggctga                                                   20


<210> 7642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7642
gtgtgggctg ggcttaggga                                                   20


<210> 7643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7643
agaggtgtgg gctgggctta                                                   20


<210> 7644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 7644
cactccgatg ggctaataga                                                   20


<210> 7645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 7645
tgactcaatg tcatgtgatt                                                   20


<210> 7646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 7646
ccactgatac agataagtct                                                   20


<210> 7647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7647
ggatacagcg caattgcaga                                                   20


<210> 7648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7648
tttgccctct ctggctagcc                                                   20


<210> 7649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7649
tcctcattgg attgggagct                                                   20


<210> 7650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 7650
ggcaagtcag ggattcctca                                                   20


<210> 7651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7651
gcagagtgta atggcaagtc                                                   20


<210> 7652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7652
actctttaat agaataatcg                                                   20


<210> 7653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 7653
aactggccag cactctttaa                                                   20


<210> 7654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7654
ggaagtttct taggacagat                                                   20


<210> 7655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 7655
gacccagaga gagagagaga                                                   20


<210> 7656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7656
gcctgagtat caccaatgga                                                   20


<210> 7657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7657
gaagccttga gccaagaagc                                                   20


<210> 7658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 7658
gtcgatgtct cggtgagttt                                                   20


<210> 7659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7659
ctggagctgt cgatgtctcg                                                   20


<210> 7660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 7660
ggggctctct gctgctgggt                                                   20


<210> 7661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7661
gccatcgggg ctctctgctg                                                   20


<210> 7662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 7662
cctgagggag tcacagatga                                                   20


<210> 7663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7663
cgagatatct cactccctga                                                   20


<210> 7664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7664
aaagacaggg gcagggaaat                                                   20


<210> 7665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 7665
ttttccccac catgcatacc                                                   20


<210> 7666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 7666
ggtctttccc ggagtctatc                                                   20


<210> 7667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CGGAGT

<400> 7667
tcctctctcc tggtctttcc                                                   20


<210> 7668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7668
attcatacag atgggatcta                                                   20


<210> 7669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7669
aactctcaca ttcatacaga                                                   20


<210> 7670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7670
tgttgactgt tcaagcctcg                                                   20


<210> 7671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7671
ggaaatgttt attgatttgg                                                   20


<210> 7672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7672
tctctgaggg ctctgggttt                                                   20


<210> 7673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7673
acactaattc tctgagggct                                                   20


<210> 7674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7674
gtggaataaa tcggtatgat                                                   20


<210> 7675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7675
aaggagttaa ggaaggtgag                                                   20


<210> 7676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7676
ataaaaagga gttaaggaag                                                   20


<210> 7677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7677
ttagtagctt agtaataaaa                                                   20


<210> 7678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 7678
acttcagttc tgtgagataa                                                   20


<210> 7679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7679
ttttaataat ggttgctaaa                                                   20


<210> 7680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 7680
ttgggcatgt attacaggca                                                   20


<210> 7681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7681
tggaaggatt tttgcatttt                                                   20


<210> 7682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7682
tcatttgctt caaaaattgg                                                   20


<210> 7683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7683
gtagtattcc cttccttaat                                                   20


<210> 7684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7684
ccagttggtc tcgttagagg                                                   20


<210> 7685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 7685
cagaccagtt ggtctcgtta                                                   20


<210> 7686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7686
aatatataga agagacccag                                                   20


<210> 7687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7687
aaccaataga aattaaatag                                                   20


<210> 7688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7688
agacttgaga gagtttgggg                                                   20


<210> 7689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 7689
tctagtaatt gaagacttga                                                   20


<210> 7690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 7690
atcaacaata aatagcatgt                                                   20


<210> 7691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7691
ttcctggagg aaggcataat                                                   20


<210> 7692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7692
aaacatccac tcttatgggg                                                   20


<210> 7693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7693
agacacatac atggtgtttt                                                   20


<210> 7694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 7694
ttttccctaa ggatttccat                                                   20


<210> 7695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7695
tagaacatgt tcttttccct                                                   20


<210> 7696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 7696
agccccacac agattagcac                                                   20


<210> 7697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7697
ccatggaaat gtcaatgaca                                                   20


<210> 7698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7698
tcagacaatc acagaacagg                                                   20


<210> 7699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7699
cagttcagac aatcacagaa                                                   20


<210> 7700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7700
tcttttcctg tgctaagccg                                                   20


<210> 7701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 7701
cacactaaca gtgtggaaaa                                                   20


<210> 7702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7702
agataatatc tgctgtgtgg                                                   20


<210> 7703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7703
tctgtgacac aatccagcct                                                   20


<210> 7704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 7704
ttcacaattt tatataatta                                                   20


<210> 7705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 7705
gaggctctgg tctgcagttc                                                   20


<210> 7706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 7706
tttcaggatt gggcaatcaa                                                   20


<210> 7707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7707
ccaatttgac tcccaggttt                                                   20


<210> 7708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7708
ggactgtgga aaaaggaaag                                                   20


<210> 7709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7709
gggaagtgga tcaacaagat                                                   20


<210> 7710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 7710
tataaggaca ccttagggaa                                                   20


<210> 7711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 7711
attatagatg gggaaaaggg                                                   20


<210> 7712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 7712
tgtaattata gatggggaaa                                                   20


<210> 7713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7713
gctggaggca tagagcctaa                                                   20


<210> 7714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 7714
agctgccgta gacaatgagt                                                   20


<210> 7715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7715
cattgcagct gccgtagaca                                                   20


<210> 7716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7716
tctgatcctt acaaccagcg                                                   20


<210> 7717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 7717
agaaggcata gaataaagcc                                                   20


<210> 7718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 7718
aatgccagtg agagaaggca                                                   20


<210> 7719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7719
aacctctctc cactcccaca                                                   20


<210> 7720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7720
tcgcaggtgc tagcagcact                                                   20


<210> 7721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 7721
agagtacccc atgaatgagt                                                   20


<210> 7722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7722
accaacagag taccccatga                                                   20


<210> 7723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7723
gggcaccaac agagtacccc                                                   20


<210> 7724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7724
ggatctgggt ggggcaccaa                                                   20


<210> 7725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7725
gctgacctgg tgaaagggat                                                   20


<210> 7726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7726
agctgtgctg acctggtgaa                                                   20


<210> 7727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CGGGAT

<400> 7727
ctgctgccat gcaagcagct                                                   20


<210> 7728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 7728
gccaaaagag actttttttg                                                   20


<210> 7729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7729
gcagagggtg gaactaaaca                                                   20


<210> 7730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7730
aagcaaaaca gaatggggca                                                   20


<210> 7731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7731
agaaagcgaa tgaagcaaaa                                                   20


<210> 7732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GCGAAT

<400> 7732
gggagtgctc tcaggagaaa                                                   20


<210> 7733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7733
ttgtgcaagt gacctattga                                                   20


<210> 7734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 7734
tctcaaagaa gaagctaagt                                                   20


<210> 7735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7735
accgtttagg gagctatagg                                                   20


<210> 7736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 7736
aggttgcaga ctgtccattc                                                   20


<210> 7737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7737
gaaggagcag gaggtttgtg                                                   20


<210> 7738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7738
ttttgtgctc gtaatcttcc                                                   20


<210> 7739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 7739
aattcagggg tccatgtgct                                                   20


<210> 7740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 7740
gaggaggctg acttaaattc                                                   20


<210> 7741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 7741
gcagacttgg ttggaggctg                                                   20


<210> 7742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7742
cactgttccg cctcatgaca                                                   20


<210> 7743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CCGGAT

<400> 7743
gccttaaaac ttctgacaac                                                   20


<210> 7744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 7744
taccttgtct gcaataagca                                                   20


<210> 7745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7745
agtattagcg tccccgtttt                                                   20


<210> 7746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 7746
ttatctgtaa agaaagaaca                                                   20


<210> 7747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7747
tcctattatg agagagagga                                                   20


<210> 7748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 7748
atcaggccat ctctgctagg                                                   20


<210> 7749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 7749
attgatcagg ccatctctgc                                                   20


<210> 7750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7750
aagaattcca tgtattcaca                                                   20


<210> 7751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7751
tggagaaatc ctgggagtaa                                                   20


<210> 7752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7752
ggagttcatg gagaaatcct                                                   20


<210> 7753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 7753
ataaggagag ccccagaggt                                                   20


<210> 7754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7754
gggttgttca catggatgtc                                                   20


<210> 7755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7755
ccatggtatg ggttgttcac                                                   20


<210> 7756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 7756
tcagagctct aatccatggt                                                   20


<210> 7757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 7757
gagatagact tggaactgat                                                   20


<210> 7758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 7758
ccaagagcct atctttaaat                                                   20


<210> 7759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 7759
aattaagaaa cctacaggaa                                                   20


<210> 7760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7760
catagaaaca aggctgccct                                                   20


<210> 7761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 7761
gtttatatgc agtggctatg                                                   20


<210> 7762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7762
cttccaaggt taaaaacaat                                                   20


<210> 7763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7763
caggggtctc aaggcagaaa                                                   20


<210> 7764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 7764
ggcactgtgg gaggaaggtc                                                   20


<210> 7765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7765
ctgtggggct gcagagaagc                                                   20


<210> 7766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7766
gcatgccgtg aaagctaaac                                                   20


<210> 7767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7767
ggccagctca ggataacgga                                                   20


<210> 7768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7768
atggcagaga gaggccagct                                                   20


<210> 7769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7769
agtgggggag tggaccaggc                                                   20


<210> 7770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7770
aggtgccagc caggcagtgg                                                   20


<210> 7771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 7771
tcctttttgt ggtaaagttg                                                   20


<210> 7772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7772
tttggttctt tggctcatga                                                   20


<210> 7773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7773
cagaatgtga gacaaagcta                                                   20


<210> 7774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7774
gaccattcca ggtggcagaa                                                   20


<210> 7775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 7775
gtaggatgtc tccaggctgg                                                   20


<210> 7776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7776
gcaggtagga tgtctccagg                                                   20


<210> 7777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 7777
ggtgagcttt caagggcagg                                                   20


<210> 7778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 7778
tttggttgcc atgtggaaat                                                   20


<210> 7779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 7779
caggagggaa cctaggagct                                                   20


<210> 7780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 7780
gattcataac aacaaatgag                                                   20


<210> 7781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7781
ggccagattc ataacaacaa                                                   20


<210> 7782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TCGAAT

<400> 7782
atgtatcaga ctttgcaatt                                                   20


<210> 7783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7783
gggtgtggat acatagagac                                                   20


<210> 7784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 7784
aaagtcacat tggaaagggt                                                   20


<210> 7785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7785
agctgaaaag tcacattgga                                                   20


<210> 7786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 7786
ggactgggat cagatgggca                                                   20


<210> 7787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7787
tgtgcatcag cattttggac                                                   20


<210> 7788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 7788
acaaatgacc ccaaaatttt                                                   20


<210> 7789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7789
agctcatggg gagggaatgt                                                   20


<210> 7790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7790
caacccagag ctcatgggga                                                   20


<210> 7791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 7791
tggcatatta tgggcacaga                                                   20


<210> 7792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ACGAGT

<400> 7792
ttcccaactt atgacaaagc                                                   20


<210> 7793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7793
ggcaatggat ctgactcagg                                                   20


<210> 7794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 7794
gtgtggcaat ggatctgact                                                   20


<210> 7795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7795
tgacccctta ctgtgtggca                                                   20


<210> 7796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7796
accacacaag gcttgggttg                                                   20


<210> 7797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 7797
ttgcattcac cacacaaggc                                                   20


<210> 7798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7798
gagctcactt tggaagactt                                                   20


<210> 7799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7799
catgtggccc agcatgccca                                                   20


<210> 7800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 7800
tcttgagttg tgttttactt                                                   20


<210> 7801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 7801
ttcctgccaa aatggttctc                                                   20


<210> 7802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 7802
cttggtatca tatagggaca                                                   20


<210> 7803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 7803
catctcacag aaaacgtgag                                                   20


<210> 7804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7804
ctactcatct cacagaaaac                                                   20


<210> 7805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7805
acctcaaaaa taaatgtgtc                                                   20


<210> 7806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 7806
tcctgtatgt agagatgaag                                                   20


<210> 7807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 7807
gaaaggtctt ggaactgccc                                                   20


<210> 7808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TCGGAT

<400> 7808
tctcagagta aatgcaagct                                                   20


<210> 7809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7809
ctgactctct gcctgcctct                                                   20


<210> 7810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7810
agttgcatcg tctttataat                                                   20


<210> 7811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7811
gatgataaaa aatgcattgc                                                   20


<210> 7812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7812
taaattgaat tgctagtgtc                                                   20


<210> 7813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7813
ctcagcataa attatttaaa                                                   20


<210> 7814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 7814
aaagacagat gccaaattac                                                   20


<210> 7815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 7815
actgacacat gtagtgctca                                                   20


<210> 7816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7816
tactgtgctg ccccttcttc                                                   20


<210> 7817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7817
cctcacatct caccatgctc                                                   20


<210> 7818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7818
tactctcaac tgggaagacc                                                   20


<210> 7819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 7819
gtaaacagaa acacccattc                                                   20


<210> 7820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7820
aggttctctc ctctcacccc                                                   20


<210> 7821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 7821
gcccccatga ggttgatggt                                                   20


<210> 7822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7822
ttaggcaatt cttgattact                                                   20


<210> 7823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7823
tttagacacc cagaggaaaa                                                   20


<210> 7824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7824
tttatttata ccttaaacta                                                   20


<210> 7825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7825
attcaggcaa gacccctcag                                                   20


<210> 7826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7826
ttcactttct gttctggttg                                                   20


<210> 7827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 7827
aagacaaagg aactgaggcc                                                   20


<210> 7828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7828
atctcaggcc tgcggacatt                                                   20


<210> 7829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7829
ggcacagcaa tagatctccg                                                   20


<210> 7830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7830
gatcacaatg catcttctca                                                   20


<210> 7831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 7831
ataacagtta gcctgtcaca                                                   20


<210> 7832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 7832
ttgccacaga gtaccgcttc                                                   20


<210> 7833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7833
atggcctggg gttcttgcca                                                   20


<210> 7834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 7834
tcatttggaa ttgtatggcc                                                   20


<210> 7835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7835
ctcagttcag cttcctcatt                                                   20


<210> 7836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 7836
tgggtgtcca tgtggggctt                                                   20


<210> 7837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 7837
aataaaataa aaagatttgc                                                   20


<210> 7838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7838
aatctcagaa atcagcgtta                                                   20


<210> 7839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TCGGGT

<400> 7839
ctgggtacag tgtacactgc                                                   20


<210> 7840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7840
aagggataag agactacaca                                                   20


<210> 7841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7841
ggaaaggtga gacgaaggta                                                   20


<210> 7842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 7842
acaagcagga gctaagctgt                                                   20


<210> 7843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7843
tattctaaat gaagtaactc                                                   20


<210> 7844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 7844
ggcattggca gcaagctgga                                                   20


<210> 7845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7845
ataatggcat tggcagcaag                                                   20


<210> 7846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7846
aatactactc agttgtaaaa                                                   20


<210> 7847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7847
aatatggtgt atgcatacca                                                   20


<210> 7848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7848
ttggtccagc aatcccacta                                                   20


<210> 7849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7849
aacaatttta cactgctggt                                                   20


<210> 7850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7850
aaaaaataat agatgttggc                                                   20


<210> 7851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7851
agataccacc ttactcctgc                                                   20


<210> 7852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7852
tccaaaagtg ggcaaaggac                                                   20


<210> 7853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 7853
ccaagtaaac agacaaccca                                                   20


<210> 7854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7854
caaaaacaaa aataaataga                                                   20


<210> 7855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7855
tatacaaaaa tcaattcaag                                                   20


<210> 7856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7856
ccacatgtgg aagaaagaaa                                                   20


<210> 7857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7857
ccctattcaa caaatggtgc                                                   20


<210> 7858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7858
aagcacatag accaatggaa                                                   20


<210> 7859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7859
tagccaaagc aagactaagc                                                   20


<210> 7860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7860
aaattcatag ggaaccaaaa                                                   20


<210> 7861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7861
aacacatccc atgctcatgg                                                   20


<210> 7862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7862
tgggaacaca tcccatgctc                                                   20


<210> 7863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7863
aataaaaaca aaaaaatctt                                                   20


<210> 7864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7864
aaatgaattc agtaaagttt                                                   20


<210> 7865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7865
aaagctccta gatctaataa                                                   20


<210> 7866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7866
agacaagaga aataaataaa                                                   20


<210> 7867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7867
cctgagaact gaaacaagac                                                   20


<210> 7868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7868
aatgctgcac gtcacataaa                                                   20


<210> 7869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7869
gggtttcata ccagggaggt                                                   20


<210> 7870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 7870
agataacaca ccatgatcaa                                                   20


<210> 7871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7871
ctcaacaaaa tgctagctaa                                                   20


<210> 7872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7872
ttccaaaaga tgcagaaaga                                                   20


<210> 7873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7873
attctatcag acattcaaag                                                   20


<210> 7874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7874
ggagcagact ggattcacag                                                   20


<210> 7875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7875
aaaaaaagtc caggagcaga                                                   20


<210> 7876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7876
aactagaaaa tttagaggag                                                   20


<210> 7877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GCGGGT

<400> 7877
aaagataagt gaaacaaaaa                                                   20


<210> 7878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7878
cccaaaccaa gcagaagaaa                                                   20


<210> 7879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7879
taatctaagg tcacacctca                                                   20


<210> 7880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 7880
acacaactta tcaaaacctc                                                   20


<210> 7881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7881
aagtttaaaa attttttgaa                                                   20


<210> 7882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 7882
aatctgctct tgaatgatct                                                   20


<210> 7883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7883
gaaaactaaa caatctgctc                                                   20


<210> 7884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CGGAGT

<400> 7884
gagcacagtc gaataaacct                                                   20


<210> 7885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TCGAAT

<400> 7885
ggtatcctct cagagcacag                                                   20


<210> 7886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7886
acattctttt catcagcaca                                                   20


<210> 7887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7887
aacattctac caaacaactg                                                   20


<210> 7888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 7888
acagcaatat aataatagtg                                                   20


<210> 7889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 7889
aatggaaacc aaaagcaagc                                                   20


<210> 7890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 7890
ctcacatctc aatactgatg                                                   20


<210> 7891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 7891
ataactagca taatgaatag                                                   20


<210> 7892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7892
ttaaggcaat aactagcata                                                   20


<210> 7893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7893
aacaataaca caataaaaaa                                                   20


<210> 7894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7894
gcactacaag aaatgctaaa                                                   20


<210> 7895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7895
ttcagacaaa caaatggtga                                                   20


<210> 7896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7896
aaacaaaata attgccagcc                                                   20


<210> 7897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 7897
ccttgcaagc cagaagggat                                                   20


<210> 7898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7898
ctgaaacctt gcaagccaga                                                   20


<210> 7899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7899
tctaaagtca agacaaagaa                                                   20


<210> 7900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7900
atccaaatac aagaagctca                                                   20


<210> 7901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7901
agtttggaaa acttatttga                                                   20


<210> 7902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7902
aataatgggt gttcccaagg                                                   20


<210> 7903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 7903
aacaaccaaa cctaagaata                                                   20


<210> 7904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7904
catgtgaaac aaccaaacct                                                   20


<210> 7905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7905
gacaaatcgg ccaataaatt                                                   20


<210> 7906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7906
aactaagaca cacaaaaaga                                                   20


<210> 7907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7907
aatttttaaa acaacaagat                                                   20


<210> 7908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7908
catctcaaaa aaaaaaaaaa                                                   20


<210> 7909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 7909
tgcactccag cctgggcaac                                                   20


<210> 7910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7910
tactcaggag actgaggcag                                                   20


<210> 7911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7911
aatctctgaa ttgccagata                                                   20


<210> 7912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7912
tccaaactaa gaagaaatct                                                   20


<210> 7913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7913
atcaaactag ctccccaaca                                                   20


<210> 7914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 7914
attctggtaa tatgacaaaa                                                   20


<210> 7915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7915
agagatcacc catgaaacaa                                                   20


<210> 7916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 7916
ctcaggaagc cccatcccca                                                   20


<210> 7917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7917
atcctggcta accagacgtc                                                   20


<210> 7918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7918
gccattaaag caactcatga                                                   20


<210> 7919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 7919
aatatttacc ctggccaact                                                   20


<210> 7920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7920
aatccctacc caagaagggt                                                   20


<210> 7921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7921
cacagcaatc cctacccaag                                                   20


<210> 7922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7922
ctcacagcct ggggcaaggt                                                   20


<210> 7923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 7923
ggaactgcaa gcagacagtg                                                   20


<210> 7924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7924
tgggcacaaa ttttcttgag                                                   20


<210> 7925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7925
gtggaatcag ggaggggtca                                                   20


<210> 7926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 7926
ggcagccagt ggaatcaggg                                                   20


<210> 7927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7927
cccttgggga aggcagccag                                                   20


<210> 7928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7928
cagtctccag cttgagacca                                                   20


<210> 7929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 7929
gagaagaatt tacccttacc                                                   20


<210> 7930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7930
gaaaatccag atcacaggag                                                   20


<210> 7931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7931
cctccaaaca tacatcccaa                                                   20


<210> 7932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 7932
gaatatacca ggagaactga                                                   20


<210> 7933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7933
tttgctccaa gaaccactgc                                                   20


<210> 7934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7934
acatgcaggt cccacttgga                                                   20


<210> 7935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 7935
ataggagagg ggacaaaatg                                                   20


<210> 7936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7936
tttagcgtca ttaccctggc                                                   20


<210> 7937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7937
tgagagatcc ttggaactgg                                                   20


<210> 7938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 7938
ggcaagagga ttttgtctaa                                                   20


<210> 7939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 7939
cttgataaag atactggcaa                                                   20


<210> 7940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7940
ctcctggaag aaggaacccc                                                   20


<210> 7941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 7941
gccctggcag acataaacag                                                   20


<210> 7942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7942
gatgagcctc cagcttcttg                                                   20


<210> 7943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7943
cactccagtt tctaaaaact                                                   20


<210> 7944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7944
cagcatagct tggcttgctt                                                   20


<210> 7945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7945
cagaaacagt ttctcattga                                                   20


<210> 7946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7946
ggagcagaaa cagtttctca                                                   20


<210> 7947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7947
gagcagaagt gaatagggag                                                   20


<210> 7948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 7948
aaacttaacg aggagcagaa                                                   20


<210> 7949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 7949
cggggtttca ccgcgttagc                                                   20


<210> 7950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CGGGGT

<400> 7950
ttttgtattt ttagtagaga                                                   20


<210> 7951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CGGAGT

<400> 7951
cattctcccg cctcagcctc                                                   20


<210> 7952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CCGGGT

<400> 7952
ctcactgcaa gctccgcctc                                                   20


<210> 7953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 7953
tcttgctctg tcacccagac                                                   20


<210> 7954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 7954
gcttctagta actttattag                                                   20


<210> 7955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7955
aggctgttgg cctcaaactc                                                   20


<210> 7956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7956
atcgcatata tgtttcttgt                                                   20


<210> 7957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 7957
ggattccttt tgcctcttcc                                                   20


<210> 7958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 7958
ttttcttctt cattcttttt                                                   20


<210> 7959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 7959
tttcctatgg gaatcacagc                                                   20


<210> 7960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7960
gtgtatcatt tttttcctat                                                   20


<210> 7961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 7961
ttgctttcct tggagttaat                                                   20


<210> 7962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 7962
cacaatgttt ttgctttcct                                                   20


<210> 7963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7963
gttcataatt taaaaggtca                                                   20


<210> 7964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 7964
tttctaattt agaaaacata                                                   20


<210> 7965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 7965
cttcccaaca acctataatt                                                   20


<210> 7966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 7966
gagcactctc tccataattt                                                   20


<210> 7967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 7967
gagccaaata ccaccaaaga                                                   20


<210> 7968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7968
gggcttatta aaaattacat                                                   20


<210> 7969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CGGGAT

<400> 7969
tgttttcaga gcctgaatat                                                   20


<210> 7970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7970
tgaatctttg ttttcagagc                                                   20


<210> 7971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7971
ccattcagaa tttgaatatt                                                   20


<210> 7972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7972
ctcagtgatc cattcagaat                                                   20


<210> 7973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 7973
gggtatctca gtgatccatt                                                   20


<210> 7974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 7974
accattttta tgaatacaag                                                   20


<210> 7975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7975
tgttttaaat taccattttt                                                   20


<210> 7976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 7976
tacacagagt tttaaaaata                                                   20


<210> 7977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 7977
gcaaatggga agggcttaca                                                   20


<210> 7978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7978
agagaggctg ctctcccaca                                                   20


<210> 7979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 7979
ctactgggct gaaatgaaaa                                                   20


<210> 7980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 7980
tgaggtacac agtggaaatt                                                   20


<210> 7981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 7981
cttattcacg gaacgcagct                                                   20


<210> 7982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 7982
gtggtgatag ttccacaata                                                   20


<210> 7983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CGGGAT

<400> 7983
ttaatgggta catttctgtt                                                   20


<210> 7984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 7984
gaatggggag ttattattta                                                   20


<210> 7985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 7985
gttgccagag agggggaatg                                                   20


<210> 7986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 7986
aatggaagtt gccagagagg                                                   20


<210> 7987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 7987
aaattcatgg agacagaaag                                                   20


<210> 7988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7988
aatatcattc agttttaaaa                                                   20


<210> 7989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7989
tgtagtatat atgtaaacaa                                                   20


<210> 7990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7990
atatgtccat caacagatga                                                   20


<210> 7991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7991
ccaaatatgt ccatcaacag                                                   20


<210> 7992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7992
ttttatagtt gaacaaaact                                                   20


<210> 7993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 7993
ttgagaagac aacaaaacta                                                   20


<210> 7994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7994
caaccccact tttaaaccaa                                                   20


<210> 7995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 7995
atgacaatga ataatgataa                                                   20


<210> 7996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 7996
agaaaatggg agccatgaca                                                   20


<210> 7997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 7997
gagacaagtg gataatggat                                                   20


<210> 7998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 7998
tgtcatgaga caagtggata                                                   20


<210> 7999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 7999
atctgtttgt catgagacaa                                                   20


<210> 8000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8000
ccattgtaaa aatacaaagc                                                   20


<210> 8001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8001
ataaggtcac aatgtaagta                                                   20


<210> 8002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8002
taatatcaca attcaaaaaa                                                   20


<210> 8003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8003
ttcattcata atggttaaca                                                   20


<210> 8004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8004
aagattaatt attatattca                                                   20


<210> 8005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8005
tgtttctcaa caagtgatct                                                   20


<210> 8006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8006
tctttcataa actgtccctt                                                   20


<210> 8007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 8007
ggttccagct gatcattttg                                                   20


<210> 8008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8008
tgttgagact ttcatcatga                                                   20


<210> 8009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8009
tgtttgttga gactttcatc                                                   20


<210> 8010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 8010
ttcactatta tgatgtttat                                                   20


<210> 8011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8011
tttttatttt tcctgtctta                                                   20


<210> 8012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8012
ttgcaatttt ggttgcccta                                                   20


<210> 8013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8013
aattgattta tcaccacagg                                                   20


<210> 8014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8014
aaactttgtt tggtaatgca                                                   20


<210> 8015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 8015
ttacttttcc atatcagttt                                                   20


<210> 8016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 8016
acatcctgag tcaacaccac                                                   20


<210> 8017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8017
agtaatctca ttgtcacatc                                                   20


<210> 8018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8018
gcaccagatt cccatgtcta                                                   20


<210> 8019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8019
ggcttccaat atttttccat                                                   20


<210> 8020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8020
atttaggtat ttcaatctcc                                                   20


<210> 8021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8021
tgtttttggg atttgcccaa                                                   20


<210> 8022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8022
atgttttaaa attatgtttt                                                   20


<210> 8023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 8023
aatctactgc aaacggggaa                                                   20


<210> 8024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8024
aaagaacatg tgaaatgaag                                                   20


<210> 8025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8025
ctccccatgc cctggtttca                                                   20


<210> 8026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 8026
accagaaggt aaagagagca                                                   20


<210> 8027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8027
gcattaaatt gtagccagtg                                                   20


<210> 8028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8028
aggaagataa taaatgtcct                                                   20


<210> 8029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8029
gggaatttat gtgacaggta                                                   20


<210> 8030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8030
acctatatgg tcacaatcct                                                   20


<210> 8031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8031
tgccaaatcg tcttccaaag                                                   20


<210> 8032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 8032
aagtagaatt gccaggtcaa                                                   20


<210> 8033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8033
taaggatgaa tttctagaag                                                   20


<210> 8034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8034
taatatgagt aaaattaagg                                                   20


<210> 8035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8035
cacataatat gagtaaaatt                                                   20


<210> 8036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8036
tgtatctttg tacacataat                                                   20


<210> 8037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 8037
caccacatat taattttttg                                                   20


<210> 8038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8038
gctgaacaga tttcatttgc                                                   20


<210> 8039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8039
attagaagat tcataattgt                                                   20


<210> 8040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 8040
ttaaaggatg tctcatgtga                                                   20


<210> 8041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8041
taaagtacct aaatgaatta                                                   20


<210> 8042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8042
agaaatttta aagtacctaa                                                   20


<210> 8043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8043
agacctaaca aaactagaaa                                                   20


<210> 8044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8044
taagtcacag catggaagca                                                   20


<210> 8045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8045
gttaaagaca tacatattca                                                   20


<210> 8046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 8046
aacagtttaa tcagaaccta                                                   20


<210> 8047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8047
atttttaaaa atctctctta                                                   20


<210> 8048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 8048
attctctgat cataatgaaa                                                   20


<210> 8049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8049
aggataaata aaaacattgt                                                   20


<210> 8050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8050
atcagaaatt attagagtag                                                   20


<210> 8051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 8051
atttataaat cagaaattat                                                   20


<210> 8052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8052
gattttaata tcagagaaag                                                   20


<210> 8053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 8053
gcaaaggcaa acaaagaaag                                                   20


<210> 8054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8054
atacagaaag gctaaaatta                                                   20


<210> 8055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8055
aagcaatacc caactctatg                                                   20


<210> 8056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8056
tgtcatgtca ctaaatataa                                                   20


<210> 8057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8057
taacatggtc acatttattt                                                   20


<210> 8058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TCGAAT

<400> 8058
aactcaaata agaaaatcgc                                                   20


<210> 8059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 8059
ggccaaatgc gttgttgatg                                                   20


<210> 8060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8060
agcttcttgt gcagttgtaa                                                   20


<210> 8061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8061
tgaccgtaga atggtcaacg                                                   20


<210> 8062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8062
cttcaactgc cgaatgaccg                                                   20


<210> 8063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CCGAAT

<400> 8063
tttccaattt gcttcaactg                                                   20


<210> 8064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8064
aatagttcat ttttgttgca                                                   20


<210> 8065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8065
acgacttttt ttggtgcaag                                                   20


<210> 8066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8066
ctcagatgta atggctttgc                                                   20


<210> 8067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8067
tgcagtcggt tgttgtggag                                                   20


<210> 8068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 8068
tgagaggtca ggtgaatatg                                                   20


<210> 8069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 8069
gttggttggt gagaggtcag                                                   20


<210> 8070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8070
tagcataaaa atccatgctt                                                   20


<210> 8071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8071
cacatttttg ccaatgagaa                                                   20


<210> 8072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 8072
tgaaaaggta caaaagtaat                                                   20


<210> 8073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8073
tgacaaactc taaatactgg                                                   20


<210> 8074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 8074
ttacttataa agacaaccac                                                   20


<210> 8075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8075
atggataaaa cagagaggaa                                                   20


<210> 8076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8076
ttattaaata cagtcagata                                                   20


<210> 8077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8077
tctataataa caagaagtta                                                   20


<210> 8078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 8078
aagaggaaag aacatgtgag                                                   20


<210> 8079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8079
ctccagaggg ggataaaaat                                                   20


<210> 8080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 8080
aaaccacggt gcctccagag                                                   20


<210> 8081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 8081
tggtaaatca cttagcagat                                                   20


<210> 8082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 8082
aaacacttgg aagaccaaaa                                                   20


<210> 8083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8083
tatacaagaa caaagagaaa                                                   20


<210> 8084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8084
ccaccctctc aaaatgccaa                                                   20


<210> 8085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8085
ttgtggttaa atatggaaga                                                   20


<210> 8086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8086
ttttgcaaaa tgagttattt                                                   20


<210> 8087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8087
gtaaaacatt tttttgcaaa                                                   20


<210> 8088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8088
taaaatgtct atgcttcttt                                                   20


<210> 8089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 8089
agacatctat aagctagaaa                                                   20


<210> 8090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8090
attgggttaa atgaagtcac                                                   20


<210> 8091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8091
ttgggcctct aaggaggtga                                                   20


<210> 8092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 8092
gtcacacaag ctgctatgga                                                   20


<210> 8093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8093
agttgtcaca caagctgcta                                                   20


<210> 8094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8094
gtcacgttcc attttatggc                                                   20


<210> 8095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8095
ggcctccagg gcagaagagg                                                   20


<210> 8096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8096
gaaaaagtac caaaaattag                                                   20


<210> 8097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8097
aaaactaaac tattttgttt                                                   20


<210> 8098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8098
aacaaaaaaa gccaaatgca                                                   20


<210> 8099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8099
agtgctgcac aacaataagg                                                   20


<210> 8100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8100
ctttagtgct gcacaacaat                                                   20


<210> 8101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 8101
cactcaaatg tccataaact                                                   20


<210> 8102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 8102
gacaacctct ttggaaagca                                                   20


<210> 8103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8103
gaaactcaca cactgctggt                                                   20


<210> 8104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8104
gtgtcacaat accaagtatt                                                   20


<210> 8105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8105
cttaaccttt ttttaaatca                                                   20


<210> 8106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8106
cttgtaaaat agcacaaaat                                                   20


<210> 8107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 8107
aaaaagcaag tgcttatatt                                                   20


<210> 8108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8108
cattttagta tactataatt                                                   20


<210> 8109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8109
tttgaaagga aaaaacaaag                                                   20


<210> 8110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 8110
atgaagccga cttgatcgtg                                                   20


<210> 8111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8111
tcattggttc tgtttgtgtg                                                   20


<210> 8112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8112
gcttttagca tgaatgggtg                                                   20


<210> 8113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8113
attgagagct tttagcatga                                                   20


<210> 8114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8114
gtttattgag agcttttagc                                                   20


<210> 8115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8115
cttccaatac tatgttgaat                                                   20


<210> 8116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8116
ccagaacttc caatactatg                                                   20


<210> 8117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8117
ttgacttcct cttttcctat                                                   20


<210> 8118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 8118
gagattttgg gctgagatga                                                   20


<210> 8119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8119
tttgtctgtt attggtgtat                                                   20


<210> 8120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8120
tctttgttgc aattgtgaat                                                   20


<210> 8121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 8121
ttattctctt tgttgcaatt                                                   20


<210> 8122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8122
atttttccta tccatgagca                                                   20


<210> 8123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8123
gtagcttgat ggggataaca                                                   20


<210> 8124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 8124
aaagtcagtg gtagcttgat                                                   20


<210> 8125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8125
ccaactttct tctttttgct                                                   20


<210> 8126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8126
cccacaccat ttattaaata                                                   20


<210> 8127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8127
ttttgtgtaa ggtataagga                                                   20


<210> 8128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 8128
gtttaagtct ttaatctatc                                                   20


<210> 8129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 8129
gtattgccta ggttttcttc                                                   20


<210> 8130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 8130
ttgcccatgc ctatgtcctg                                                   20


<210> 8131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8131
gcagaagctc tttagtttaa                                                   20


<210> 8132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 8132
gtttaagttt tttgtagatt                                                   20


<210> 8133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8133
atcctttgcc cactttttga                                                   20


<210> 8134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8134
tttctggttc tagatccttg                                                   20


<210> 8135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8135
tatacccagt aatggaattg                                                   20


<210> 8136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8136
tttgggtata tacccagtaa                                                   20


<210> 8137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8137
gtagaataat ttataatcct                                                   20


<210> 8138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8138
gcatgcttgt atctttatag                                                   20


<210> 8139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8139
agtctatcac tgatgggcgt                                                   20


<210> 8140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8140
tgttcttatg tcagtttgct                                                   20


<210> 8141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8141
tcattgttca tctcccacct                                                   20


<210> 8142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 8142
ttaaatttta ctttaagttc                                                   20


<210> 8143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 8143
cacacaagaa tcaattctag                                                   20


<210> 8144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8144
tccaactttg caccacacac                                                   20


<210> 8145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8145
aaaaatgatg ctgaagaatt                                                   20


<210> 8146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8146
gtcttcaaaa aatgatgctg                                                   20


<210> 8147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8147
gccattggtg taagattggt                                                   20


<210> 8148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 8148
aagtgggaga actcattcta                                                   20


<210> 8149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8149
ttttaaaatg tcaagtatct                                                   20


<210> 8150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8150
aaaagagtat agtaaggtag                                                   20


<210> 8151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8151
taaacagtaa gaattaataa                                                   20


<210> 8152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8152
ataacctaga gataaacagt                                                   20


<210> 8153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 8153
gggattgcat cactctgata                                                   20


<210> 8154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 8154
aagtataata attttaaaaa                                                   20


<210> 8155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ACGGGT

<400> 8155
gtgcagcaaa ccaccatggc                                                   20


<210> 8156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 8156
ctaatgtaaa tgacgggttg                                                   20


<210> 8157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ACGGGT

<400> 8157
agaaatacct aatgtaaatg                                                   20


<210> 8158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8158
gaggggtggg gggctagggg                                                   20


<210> 8159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 8159
gaacacactg gggcctgttg                                                   20


<210> 8160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8160
gtatgttctc actcataagt                                                   20


<210> 8161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8161
ttcatgtcct ttgcagggac                                                   20


<210> 8162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8162
ctatgcagtc ataaaaaagg                                                   20


<210> 8163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8163
aatgctatgc agtcataaaa                                                   20


<210> 8164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8164
aatgtggcac atatacacca                                                   20


<210> 8165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8165
ttagaaaagt tgaaatagaa                                                   20


<210> 8166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8166
ttattaatag attaaaggaa                                                   20


<210> 8167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8167
tccatatcca cacatctggg                                                   20


<210> 8168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8168
cccctatagt ttcagaatct                                                   20


<210> 8169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8169
gggtgaaacc cctatagttt                                                   20


<210> 8170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 8170
tattctattt ccctaggtta                                                   20


<210> 8171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8171
gaactaagaa caaatggctc                                                   20


<210> 8172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8172
gtctaaggtg gcctgggaag                                                   20


<210> 8173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8173
tggggagatt ttttaaatgc                                                   20


<210> 8174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8174
catgcctcat gtgggtaatg                                                   20


<210> 8175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 8175
tttatcctgc catgcctcat                                                   20


<210> 8176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 8176
gaccttccag agaaaattga                                                   20


<210> 8177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 8177
aactgacctt ccagagaaaa                                                   20


<210> 8178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8178
gctaatattg gctaagattt                                                   20


<210> 8179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8179
gagtttgtta tcaaacagat                                                   20


<210> 8180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 8180
ctgtttcctt ctatcttgct                                                   20


<210> 8181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8181
cagaaggaca ttttggaaaa                                                   20


<210> 8182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8182
tctaactttt ctttgtcttt                                                   20


<210> 8183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 8183
cactccagcc taatcctact                                                   20


<210> 8184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 8184
tattctccac tctagctatt                                                   20


<210> 8185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8185
acttctgctc aaattgaaaa                                                   20


<210> 8186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8186
ggaaaatgtg gtttaattaa                                                   20


<210> 8187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8187
acacgatttt agtttaatcc                                                   20


<210> 8188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8188
atattacttt taaatatttg                                                   20


<210> 8189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8189
taattctaat cacatttgct                                                   20


<210> 8190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8190
actccagccc caaaagatac                                                   20


<210> 8191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 8191
ctggacagaa aagctgttga                                                   20


<210> 8192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 8192
atgagtaaat aattgcttgg                                                   20


<210> 8193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8193
tctcttcatc ttgagatttg                                                   20


<210> 8194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 8194
taaaaagaac caagtgacca                                                   20


<210> 8195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 8195
ggattctggt tgaattacat                                                   20


<210> 8196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8196
ctcctcttta tggattctgg                                                   20


<210> 8197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8197
aaacatacaa actcctcttt                                                   20


<210> 8198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8198
tctcaatgtg tcgtctctgc                                                   20


<210> 8199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 8199
gaagtagggt ggaaagtaat                                                   20


<210> 8200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 8200
cagtatctac agtgaggaag                                                   20


<210> 8201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8201
tgaattttca gattctacag                                                   20


<210> 8202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8202
tacgttttct gagctgaatc                                                   20


<210> 8203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8203
caagaattac gttttctgag                                                   20


<210> 8204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8204
tttctttctg gctggccagc                                                   20


<210> 8205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8205
cctaactctg aggcagattg                                                   20


<210> 8206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8206
cttagaaggc ttcagtaaaa                                                   20


<210> 8207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8207
cttgcaggag gttgatgtac                                                   20


<210> 8208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8208
ctaagatcct tggtcatcgg                                                   20


<210> 8209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8209
tttggtttcc taagatcttc                                                   20


<210> 8210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 8210
aatgtcagaa gctgctttca                                                   20


<210> 8211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8211
attggtcaaa tgtctactat                                                   20


<210> 8212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8212
tttgggcaga tgagataggc                                                   20


<210> 8213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 8213
agactaatct agacacacct                                                   20


<210> 8214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8214
ttatgcaaca cacaggtggt                                                   20


<210> 8215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8215
gcaacagagc ccttatccaa                                                   20


<210> 8216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8216
tttaaaaaca tggttgtata                                                   20


<210> 8217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8217
gaggatcttg ctgagagggt                                                   20


<210> 8218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 8218
agagatgagg atcttgctga                                                   20


<210> 8219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8219
gcactgtcag tcccagagat                                                   20


<210> 8220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8220
ataacacctc ttaccagcct                                                   20


<210> 8221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 8221
taacttcacc atcctgttgc                                                   20


<210> 8222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8222
cagaagaaac attacaaaac                                                   20


<210> 8223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8223
ctcagaggga gaaaccagga                                                   20


<210> 8224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8224
tcttcctcct ctcccatgcc                                                   20


<210> 8225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8225
gcagagtaaa taaaaaggca                                                   20


<210> 8226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 8226
gccatctcaa atatggctag                                                   20


<210> 8227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8227
tgtttgggag ttaggaggac                                                   20


<210> 8228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8228
aaaatggtga atgcatgttt                                                   20


<210> 8229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 8229
gttctacgag ccaaaaaatg                                                   20


<210> 8230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8230
tccctgaaat caaaaagttt                                                   20


<210> 8231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 8231
tggggtcctc aataaggttt                                                   20


<210> 8232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 8232
caacataaac aaaagttatt                                                   20


<210> 8233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8233
gttttaaaat ttcctgagtt                                                   20


<210> 8234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8234
ttcccgtgtt ttaaaatttc                                                   20


<210> 8235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8235
gtcatcactc taaaagctac                                                   20


<210> 8236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 8236
gaatatagag gctattgatg                                                   20


<210> 8237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 8237
tctcttatga tcatacattg                                                   20


<210> 8238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8238
aaactattgt ataacaatac                                                   20


<210> 8239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 8239
gtgtccccaa aactgtttta                                                   20


<210> 8240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8240
cggtgaggac agaaagcagg                                                   20


<210> 8241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 8241
atggcggtga ggacagaaag                                                   20


<210> 8242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8242
gcctggggcc tccagaggag                                                   20


<210> 8243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 8243
ctctggcctg gggcctccag                                                   20


<210> 8244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8244
agggaaagtt ggctgttccc                                                   20


<210> 8245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8245
taacttattt gatgatctct                                                   20


<210> 8246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8246
ccagaaagtc ctccttggcc                                                   20


<210> 8247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8247
accgggtaag agctactagt                                                   20


<210> 8248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CCGGGT

<400> 8248
gatccgttct acagcacaca                                                   20


<210> 8249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8249
aactgatcgg ggagcccctg                                                   20


<210> 8250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CGGAGT

<400> 8250
caacttccgt cgctttactc                                                   20


<210> 8251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8251
tgagaagatg gaattcccca                                                   20


<210> 8252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8252
cctgaagaag aatgagaaga                                                   20


<210> 8253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8253
agtataaata cttcctgaag                                                   20


<210> 8254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8254
gtggttatgt ccactcttat                                                   20


<210> 8255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 8255
ttcagggagg ggccagatat                                                   20


<210> 8256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 8256
gttcctggga ggagccaagt                                                   20


<210> 8257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8257
cctgaatgcc ttgcagggga                                                   20


<210> 8258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8258
ctcccctgaa tgccttgcag                                                   20


<210> 8259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8259
ggttgaataa acagcctccc                                                   20


<210> 8260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8260
ctgaggcacc tggaggaggg                                                   20


<210> 8261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 8261
taaccctgag gcacctggag                                                   20


<210> 8262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 8262
gctaaatctg gtggtggtgg                                                   20


<210> 8263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 8263
aaagtctttg atgaatatgg                                                   20


<210> 8264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8264
actataaacc aaagtctttg                                                   20


<210> 8265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8265
aatgaaattc tccaataatc                                                   20


<210> 8266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8266
gggatttagg ataagggtga                                                   20


<210> 8267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 8267
ttagccttgg gatttaggat                                                   20


<210> 8268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 8268
attgacttag ccttgggatt                                                   20


<210> 8269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8269
gttctagatt gacttagcct                                                   20


<210> 8270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8270
actagaagaa actgctgact                                                   20


<210> 8271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8271
aagacaggga atagtgagaa                                                   20


<210> 8272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8272
gcttactgca agggaagaca                                                   20


<210> 8273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 8273
gtttgatggt atgaagttgg                                                   20


<210> 8274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 8274
aaagaaggct gcagacacag                                                   20


<210> 8275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8275
agagggaaag gaatggtcct                                                   20


<210> 8276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8276
aagatcctaa gcagagggaa                                                   20


<210> 8277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 8277
caggagagag gagggaagac                                                   20


<210> 8278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 8278
ctgaaaagtg actggaaaca                                                   20


<210> 8279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CCGGGT

<400> 8279
ttgcaccact gcactctagt                                                   20


<210> 8280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8280
tattcgggag gctgaggtgg                                                   20


<210> 8281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CCGAGT

<400> 8281
aaaaattttt tcaaaactag                                                   20


<210> 8282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 8282
gagaaagtta ggaaaaccaa                                                   20


<210> 8283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 8283
attattctga aaacaaaaga                                                   20


<210> 8284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8284
atccagagtc tgaaatacag                                                   20


<210> 8285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 8285
tgcatgaaaa ttgcttaatc                                                   20


<210> 8286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8286
agagattgtg gcaaacatac                                                   20


<210> 8287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8287
taaatgagaa gtgaagatat                                                   20


<210> 8288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8288
aaagaagtga ggagataatt                                                   20


<210> 8289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8289
actagatgtt tgattgtatg                                                   20


<210> 8290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8290
taggttagaa aggactaaag                                                   20


<210> 8291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8291
atatcatttg gccactgttg                                                   20


<210> 8292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8292
ttgagtgcta tggagagctt                                                   20


<210> 8293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 8293
agcgcacagt ttgggttatc                                                   20


<210> 8294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8294
tggagaggtc agcgcacagt                                                   20


<210> 8295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8295
aaaaagaatg ggtcaaattc                                                   20


<210> 8296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8296
aagccttaac ataaaaaaga                                                   20


<210> 8297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8297
ggaaaagcct taacataaaa                                                   20


<210> 8298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8298
ataattttag gcaaaggaag                                                   20


<210> 8299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8299
ccaagagtac aagaataaga                                                   20


<210> 8300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8300
tgtctcaaag ccaagagtac                                                   20


<210> 8301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8301
gaagaaattg tctcaaagcc                                                   20


<210> 8302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8302
gagttatggg aacatgaaac                                                   20


<210> 8303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 8303
atgtttatag agaaagtgca                                                   20


<210> 8304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 8304
caatgctgaa caaaatagat                                                   20


<210> 8305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8305
ggttccttat attcctatta                                                   20


<210> 8306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 8306
tgccaccatc tgcttgactt                                                   20


<210> 8307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 8307
gcaagcagga tctccatcat                                                   20


<210> 8308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 8308
ctaggtatgg tgggagcaag                                                   20


<210> 8309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8309
gtgtctatat cacagaggta                                                   20


<210> 8310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8310
gagcctccta catatgggta                                                   20


<210> 8311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8311
accagcagag cctcctacat                                                   20


<210> 8312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 8312
agaggaatgg tgtcagagca                                                   20


<210> 8313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8313
aatggaggac attaaggaag                                                   20


<210> 8314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 8314
aataggcagg aggagaggaa                                                   20


<210> 8315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8315
cataaataca ccatgttaat                                                   20


<210> 8316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8316
gacactgaag tcaacagtgt                                                   20


<210> 8317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8317
atctttgttt ctcagaaggg                                                   20


<210> 8318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8318
gttactaaac aactgagtcc                                                   20


<210> 8319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8319
cttgcattgt tactaaacaa                                                   20


<210> 8320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8320
ttgcattcca gtgtcactga                                                   20


<210> 8321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8321
caagctccag ctccaggacc                                                   20


<210> 8322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8322
gcatgaagtc agtctcatag                                                   20


<210> 8323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8323
tggagggatt tatggtagcc                                                   20


<210> 8324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8324
acaattttgt ccttagctgg                                                   20


<210> 8325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8325
atagagaacc acttcaatca                                                   20


<210> 8326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8326
aaagacactg ggtaatagat                                                   20


<210> 8327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8327
cagaatgtca tgtaaagaca                                                   20


<210> 8328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8328
ttgcacccca atagttttct                                                   20


<210> 8329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8329
tctgagccca gtttgcccat                                                   20


<210> 8330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 8330
ggccactgaa gtaagttctg                                                   20


<210> 8331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8331
ctgcaccttg ctcatttccc                                                   20


<210> 8332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8332
attcaactag actctaaaat                                                   20


<210> 8333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8333
tttgatatgg ctacctcaca                                                   20


<210> 8334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 8334
ctcagccatt aatccaagaa                                                   20


<210> 8335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8335
taaactagaa tagatatttc                                                   20


<210> 8336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8336
ggccgagctt ggagctaaac                                                   20


<210> 8337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8337
ggaacagcta ttaaacttaa                                                   20


<210> 8338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CCGAAT

<400> 8338
ttgggagggc tgaatgccca                                                   20


<210> 8339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8339
gttggttcat cttgggaggg                                                   20


<210> 8340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 8340
ctgcactcca gcctggacaa                                                   20


<210> 8341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8341
tacttgggag gctgaggtgg                                                   20


<210> 8342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8342
tttgtgtggc tttctgtaaa                                                   20


<210> 8343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8343
tttctgtaaa cagaatttat                                                   20


<210> 8344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 8344
ttgactgaca ctctttttcc                                                   20


<210> 8345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8345
atttaaattt aatgtaattt                                                   20


<210> 8346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8346
atttatgaat atttttgttt                                                   20


<210> 8347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CCGGGT

<400> 8347
attctgtatg tctctatatc                                                   20


<210> 8348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 8348
tattattata ctttaagttt                                                   20


<210> 8349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8349
ttattgttca attcccacct                                                   20


<210> 8350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8350
tgtccttgcg atagtttgct                                                   20


<210> 8351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8351
agtctatcac tgttggacat                                                   20


<210> 8352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 8352
ggttccaagt ctttgctatt                                                   20


<210> 8353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8353
gcagtatgat ttataatcct                                                   20


<210> 8354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8354
tttgggtata tacccagtaa                                                   20


<210> 8355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8355
tatacccagt aatgggatgg                                                   20


<210> 8356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8356
tttctggttc tagatccctg                                                   20


<210> 8357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8357
atccttcgcc cactttttga                                                   20


<210> 8358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 8358
ttttttcctt gtaaatttgt                                                   20


<210> 8359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 8359
gtttgagttc attgtagatt                                                   20


<210> 8360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8360
ggatattagc ccttcgtcag                                                   20


<210> 8361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8361
tccttgccca tgcctatgtc                                                   20


<210> 8362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 8362
gtattgccta ggttctcttc                                                   20


<210> 8363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8363
atttaagtct ttaatccatc                                                   20


<210> 8364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8364
ttttgtataa ggtgtaagga                                                   20


<210> 8365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8365
ccagcaccat ttattaaata                                                   20


<210> 8366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8366
gacaaacaga gagccaaatc                                                   20


<210> 8367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8367
ccattcacaa ttgcttcaaa                                                   20


<210> 8368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8368
tcaaagagaa taaaatacct                                                   20


<210> 8369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8369
acctaggaat gcaacttaca                                                   20


<210> 8370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8370
cactgctcag tgaaataaaa                                                   20


<210> 8371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8371
aagaggatac aaacaaatgg                                                   20


<210> 8372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8372
tggaagaata ctccatgctc                                                   20


<210> 8373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8373
actccatgct catgggtagg                                                   20


<210> 8374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8374
gctaccaatg actttcttct                                                   20


<210> 8375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ACGGGT

<400> 8375
agaaatacct aatgtagatg                                                   20


<210> 8376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8376
ctaatgtaga tgacgggttg                                                   20


<210> 8377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8377
tacattgtgc acatgtaccc                                                   20


<210> 8378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8378
attttaaaaa aagaaaaaaa                                                   20


<210> 8379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 8379
tacctactat tctgtgttaa                                                   20


<210> 8380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8380
ttctgtgtta agtggatgtt                                                   20


<210> 8381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 8381
agattctagt tttacctctt                                                   20


<210> 8382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 8382
ctagttttac ctcttgtggg                                                   20


<210> 8383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8383
ttcaaaagat aatcttgcat                                                   20


<210> 8384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8384
ttgtgcagaa aaaatgagaa                                                   20


<210> 8385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8385
gagaaatgga ttagtttccc                                                   20


<210> 8386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8386
tattttagca acaccagtca                                                   20


<210> 8387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8387
ggattagggc tcaccttcat                                                   20


<210> 8388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8388
aagcataatt caacataaag                                                   20


<210> 8389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8389
ctcaaagtaa aaatactttt                                                   20


<210> 8390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8390
tggctttttc atcatccaca                                                   20


<210> 8391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CCGGGT

<400> 8391
cacagtcagt atctgtgctc                                                   20


<210> 8392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8392
gttcagtggt acgagagagg                                                   20


<210> 8393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8393
atttggttga actcatcttt                                                   20


<210> 8394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8394
tagaataaat caggcattca                                                   20


<210> 8395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 8395
catcttatta acctgcatct                                                   20


<210> 8396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8396
aatgatcaaa tatatagaca                                                   20


<210> 8397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8397
acaatgaatt ggctatatat                                                   20


<210> 8398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8398
gaatctttgt gattgtggct                                                   20


<210> 8399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8399
attgtggctg ggaatgggcc                                                   20


<210> 8400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8400
ctatgtccta tgttgttata                                                   20


<210> 8401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 8401
tacgtaatta ataacatttg                                                   20


<210> 8402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8402
taattaataa catttgcagg                                                   20


<210> 8403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 8403
ctggccatac cttttatcta                                                   20


<210> 8404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8404
tcttctgatt atattaacta                                                   20


<210> 8405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8405
tatgagatgt gaacagactc                                                   20


<210> 8406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8406
cagccatttc agcctcagaa                                                   20


<210> 8407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8407
tataaatggg gcaggcacca                                                   20


<210> 8408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 8408
cagacaattg gtggaaaagt                                                   20


<210> 8409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 8409
aatctcaaac tgaaaaatat                                                   20


<210> 8410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 8410
tatcaggatc ccagaaagtg                                                   20


<210> 8411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8411
atttaaaaat attaatttta                                                   20


<210> 8412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8412
cataggccac aggtgttacc                                                   20


<210> 8413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8413
acaacaaaaa taaaaggaca                                                   20


<210> 8414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 8414
aggacaaggg atattttctg                                                   20


<210> 8415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8415
atgcattggt gaggctgtag                                                   20


<210> 8416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8416
gggtgtgatc tgcaatggga                                                   20


<210> 8417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8417
ataactgaac atatccaggc                                                   20


<210> 8418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8418
tgacactctc ataggacggt                                                   20


<210> 8419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8419
aagcagtttc agatttgtct                                                   20


<210> 8420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 8420
gtacacaatt ttcatttgct                                                   20


<210> 8421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8421
atgcaacaaa accttcatct                                                   20


<210> 8422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 8422
tcctcagctc tgggcacaca                                                   20


<210> 8423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 8423
tgggcacaca tggggtgtta                                                   20


<210> 8424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8424
acatagctcc gataggcctt                                                   20


<210> 8425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 8425
atgtcttctt gcttccatcg                                                   20


<210> 8426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 8426
gagtggttgc tattggttca                                                   20


<210> 8427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8427
ctcctccata tttgccttca                                                   20


<210> 8428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CCGGAT

<400> 8428
ccttcagaga atccaactcc                                                   20


<210> 8429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8429
acattcttgg tgaaagcaaa                                                   20


<210> 8430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 8430
gcaaaaagga tgtccaagca                                                   20


<210> 8431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 8431
gggaccaaag gcaggtccat                                                   20


<210> 8432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8432
tctggatcag tatatttcga                                                   20


<210> 8433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8433
agtatatttc gattgggttt                                                   20


<210> 8434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 8434
gggattctca ggggaccaga                                                   20


<210> 8435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8435
agagcagaaa aggtaataaa                                                   20


<210> 8436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8436
ggtaataaac tgagtggcct                                                   20


<210> 8437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8437
gtggccacat tgaagttctc                                                   20


<210> 8438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 8438
gccattgctg ttgggcagat                                                   20


<210> 8439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8439
cagtaggggg gccctgtgtt                                                   20


<210> 8440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 8440
aaagctggac ataccgaaga                                                   20


<210> 8441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8441
tagagtagat gaacatgaca                                                   20


<210> 8442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GCGGAT

<400> 8442
atgagggcaa agagcagtgt                                                   20


<210> 8443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TCGGAT

<400> 8443
gtgcggatcc ccttggccgc                                                   20


<210> 8444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8444
ttggccgctc ggatcagtct                                                   20


<210> 8445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GCGGAT

<400> 8445
atgcggccaa ttcgggccag                                                   20


<210> 8446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8446
aagtaacttt gaagtgactt                                                   20


<210> 8447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8447
atgttatctt tgcctccgcc                                                   20


<210> 8448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8448
cctccctgat actgcagcct                                                   20


<210> 8449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8449
tgttaattac aagggggcct                                                   20


<210> 8450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8450
tggctgacag ctaaagcata                                                   20


<210> 8451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8451
acagctaaag cataagggat                                                   20


<210> 8452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8452
ctggagatag gtttttttgg                                                   20


<210> 8453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8453
tgaacaaagt tggaaatata                                                   20


<210> 8454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 8454
ggcaaggcct ttaggtaaga                                                   20


<210> 8455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8455
atctcacagg aaaaatggtg                                                   20


<210> 8456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8456
tgctctttgt tgttatgcac                                                   20


<210> 8457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8457
cttgggaaat aattataatt                                                   20


<210> 8458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 8458
atctttgtgg aagaccttct                                                   20


<210> 8459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 8459
taggacatgt tcccatcgtg                                                   20


<210> 8460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 8460
cagcacattt taatttgctc                                                   20


<210> 8461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8461
tccaggatct tattttaagg                                                   20


<210> 8462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 8462
aagaaaggga ggtaaggaga                                                   20


<210> 8463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 8463
gagggtagaa agattgatat                                                   20


<210> 8464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8464
gcttattttc cagctctata                                                   20


<210> 8465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GCGGAT

<400> 8465
tataagggat tcctgcccca                                                   20


<210> 8466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8466
tataaaatca aaatagcctt                                                   20


<210> 8467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8467
gacatgattg catttatata                                                   20


<210> 8468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8468
tagtcaaact catgggagca                                                   20


<210> 8469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8469
aaactcatgg gagcagagaa                                                   20


<210> 8470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8470
caaacttcca gttatgtgac                                                   20


<210> 8471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8471
tctacctaaa aatttgccaa                                                   20


<210> 8472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8472
ttgatggtgg tgatggtttc                                                   20


<210> 8473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 8473
acatgtatag ctttttacat                                                   20


<210> 8474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 8474
gacatgaaaa gtaagcaggt                                                   20


<210> 8475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 8475
tgagcatgat ttggccttta                                                   20


<210> 8476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8476
ctgcataata ttcttgatct                                                   20


<210> 8477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8477
caattttaaa tgtataaaat                                                   20


<210> 8478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8478
taattccaga ccctagactt                                                   20


<210> 8479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 8479
tacggtctga ggttctcagg                                                   20


<210> 8480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 8480
ctcttggaaa gctgcaaata                                                   20


<210> 8481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8481
aagaactggt tgattttgcc                                                   20


<210> 8482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8482
ggcatctgtg ttatctgtag                                                   20


<210> 8483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 8483
ctgtctaaat tccaacagtc                                                   20


<210> 8484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8484
tttaagctcc acttactgca                                                   20


<210> 8485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 8485
acacactacc ctgtcccttt                                                   20


<210> 8486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TCGAGT

<400> 8486
atcccacttt tcagtcagcc                                                   20


<210> 8487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8487
tgcagtgccc tgcacattgc                                                   20


<210> 8488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 8488
ttaatttgag ctactttgct                                                   20


<210> 8489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 8489
gcaaatgcag gtatagggcg                                                   20


<210> 8490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 8490
gtttgcatct tggaaggagg                                                   20


<210> 8491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 8491
ttggaaggag gcagagtggc                                                   20


<210> 8492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 8492
tgtgaacatc ttactgctct                                                   20


<210> 8493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 8493
tcccctaccc catgtacctc                                                   20


<210> 8494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8494
gtccctctgc ctcagtaatg                                                   20


<210> 8495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8495
tagtttctcc taacttaaag                                                   20


<210> 8496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8496
ttcaaagcaa aatttcttga                                                   20


<210> 8497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8497
agattgttct cactaagatc                                                   20


<210> 8498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 8498
tttacccaac ttttagacat                                                   20


<210> 8499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8499
ccttgacaat ttatccagcc                                                   20


<210> 8500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8500
gtcactggac tgtaaactgt                                                   20


<210> 8501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8501
gatgctctgc aaatttgtaa                                                   20


<210> 8502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8502
atttgtaaat gaatggaaga                                                   20


<210> 8503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8503
ggaagacaga atgggcagct                                                   20


<210> 8504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 8504
actaaattca attctgtacc                                                   20


<210> 8505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8505
ttctgtacca agggtacata                                                   20


<210> 8506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8506
aagggtacat actgaatgta                                                   20


<210> 8507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8507
tgggatgtgc aagcctctgc                                                   20


<210> 8508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 8508
cttgccttct gcttcatggt                                                   20


<210> 8509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8509
ccttctgctt catggtgggg                                                   20


<210> 8510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8510
ggggatgggt tgctatcctg                                                   20


<210> 8511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8511
tatcctgttg ggttagagca                                                   20


<210> 8512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 8512
catctttcct ggggcaggag                                                   20


<210> 8513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8513
gcaacggcat cgttaagtgg                                                   20


<210> 8514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 8514
ggctgggtgt gaagtttgcc                                                   20


<210> 8515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8515
ccctggatat tctgacttta                                                   20


<210> 8516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8516
gatattctga ctttagggaa                                                   20


<210> 8517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8517
gagtagcttg ctagctgctc                                                   20


<210> 8518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8518
tcttggatta gcccacggtc                                                   20


<210> 8519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 8519
gtgctctcag agacgatgaa                                                   20


<210> 8520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8520
cctattatat ttctataaag                                                   20


<210> 8521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8521
ttttattgat ttctgtagca                                                   20


<210> 8522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8522
ttctgtagca gggaatgtta                                                   20


<210> 8523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8523
aataaaattt cccagtcttg                                                   20


<210> 8524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 8524
agcaagctgg gcctgggaag                                                   20


<210> 8525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8525
tgggaagaag ggtcttagtt                                                   20


<210> 8526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8526
gaagggtctt agttgggagt                                                   20


<210> 8527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8527
agtgggaatt tccttttgcc                                                   20


<210> 8528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 8528
cggcttgtgc cactgggcat                                                   20


<210> 8529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8529
tcaaagatgt tgcctgccat                                                   20


<210> 8530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 8530
tttggatgct ggtcaggagc                                                   20


<210> 8531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8531
gctaggatgg tccaagacct                                                   20


<210> 8532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8532
ggtccaagac ctatgggtcc                                                   20


<210> 8533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8533
cgaaattagg gaacaaagga                                                   20


<210> 8534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8534
agtgtttacc ttgcttgggc                                                   20


<210> 8535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 8535
actaaggcta gcaaaaggtt                                                   20


<210> 8536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 8536
aggctagcaa aaggttgaga                                                   20


<210> 8537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8537
atccactctt cttccattca                                                   20


<210> 8538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8538
cttcttccat tcaaaggatg                                                   20


<210> 8539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8539
aggatggaga atctcaggaa                                                   20


<210> 8540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8540
ctccccctgt gccatcctcg                                                   20


<210> 8541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8541
tcccactcct atttactgcc                                                   20


<210> 8542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 8542
actgcctgga atttcaacat                                                   20


<210> 8543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 8543
ttgtaggtag atgccctctc                                                   20


<210> 8544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8544
aatatgattt atcttgtcct                                                   20


<210> 8545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 8545
aagctttctt tggcagccta                                                   20


<210> 8546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8546
ttctttggca gcctatgggg                                                   20


<210> 8547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8547
ggtgatgaca gggaagaagc                                                   20


<210> 8548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 8548
gctgggatgt caaagagaga                                                   20


<210> 8549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 8549
aaaactttca tgtttttgcc                                                   20


<210> 8550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 8550
ccttggcatc tggctcaaat                                                   20


<210> 8551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 8551
gcttgcttct cagtaagtct                                                   20


<210> 8552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8552
ctcctctcat tacccatgac                                                   20


<210> 8553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8553
tccactgaac ttgttgatgg                                                   20


<210> 8554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8554
aatccagtta tcttgattgt                                                   20


<210> 8555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8555
cccattgtaa tacttcttat                                                   20


<210> 8556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8556
aaatctaata gcttggctaa                                                   20


<210> 8557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8557
acagggccaa ttccattcac                                                   20


<210> 8558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 8558
ggccaattcc attcactgga                                                   20


<210> 8559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8559
taggtgatat catgtgtggt                                                   20


<210> 8560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 8560
cttgagatct ttatgaaaaa                                                   20


<210> 8561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 8561
tatgaaaaaa ggagtgaaac                                                   20


<210> 8562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TCGAGT

<400> 8562
tttttgccca atctttaaac                                                   20


<210> 8563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8563
gcccaatctt taaactcgag                                                   20


<210> 8564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8564
accactacca tgactgcatc                                                   20


<210> 8565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8565
tgcatcttgg atcctgacag                                                   20


<210> 8566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8566
cttggatcct gacaggggag                                                   20


<210> 8567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 8567
cctctctata cctgtaggcg                                                   20


<210> 8568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8568
ctatacctgt aggcgtgggg                                                   20


<210> 8569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 8569
tgtaggcgtg gggtagaata                                                   20


<210> 8570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8570
taaccacaca agtttaatcc                                                   20


<210> 8571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 8571
gtatgtttac tccagaagac                                                   20


<210> 8572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8572
cacaggcata gactgtcatg                                                   20


<210> 8573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8573
ctggggctca ccaggggccg                                                   20


<210> 8574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ACGGAT

<400> 8574
taaagcaaga ggaaccccct                                                   20


<210> 8575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8575
atcagaacag gcaggagaga                                                   20


<210> 8576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 8576
acaaaccaag cccagcatca                                                   20


<210> 8577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8577
ccagtgtcgg aacggtggga                                                   20


<210> 8578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8578
ttccattgct gactccctgc                                                   20


<210> 8579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8579
aaagccagtt tctgttctcc                                                   20


<210> 8580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 8580
tctccaggga tccagagatg                                                   20


<210> 8581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 8581
ggatccagag atgctggata                                                   20


<210> 8582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 8582
gatgctggat aaagggtggg                                                   20


<210> 8583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8583
tgttggttca aatctgagcc                                                   20


<210> 8584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 8584
agtaaaattc tttgggcttc                                                   20


<210> 8585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8585
ggacaattac tgccttatcc                                                   20


<210> 8586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 8586
acgaagatgt tttcctccct                                                   20


<210> 8587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8587
gatgttttcc tcccttagga                                                   20


<210> 8588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8588
agtttttctt taggggccct                                                   20


<210> 8589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8589
ggaaactggg ctgagatctg                                                   20


<210> 8590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 8590
agaaggaaag ggcaagggca                                                   20


<210> 8591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8591
tcatgctgag aactctgacc                                                   20


<210> 8592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 8592
tcaataatct caaacctccc                                                   20


<210> 8593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8593
ttatgctcag aaccctgggc                                                   20


<210> 8594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8594
gggcaaggat ttcctgtaag                                                   20


<210> 8595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 8595
tatgctcagt gatctttgtt                                                   20


<210> 8596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 8596
ttacccctca ccacaatcca                                                   20


<210> 8597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8597
agtaggtatt attagcccca                                                   20


<210> 8598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8598
ggtattatta gccccattga                                                   20


<210> 8599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 8599
atgagaaaac tgagactcag                                                   20


<210> 8600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 8600
catgagccat ccacaagtag                                                   20


<210> 8601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8601
catccacaag tagttgagtc                                                   20


<210> 8602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGGAT

<400> 8602
ccatgtagcc ccttttctct                                                   20


<210> 8603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 8603
gaacagcgcc tatctacctc                                                   20


<210> 8604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8604
gtatggaagg cattaaatga                                                   20


<210> 8605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8605
tataaacatg agaggttatc                                                   20


<210> 8606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 8606
gggattcgat tcctattaat                                                   20


<210> 8607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 8607
gccttcctcc ccatcccaag                                                   20


<210> 8608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8608
ctccccatcc caaggagggt                                                   20


<210> 8609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 8609
gccctgactc agtcctttgt                                                   20


<210> 8610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 8610
gaccaagatc cctttgagat                                                   20


<210> 8611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8611
atccctttga gatgtgaatc                                                   20


<210> 8612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8612
ttgagatgtg aatcctgagt                                                   20


<210> 8613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 8613
tgcaacagca atcacagggc                                                   20


<210> 8614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 8614
tgatattaaa gtgatgggct                                                   20


<210> 8615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8615
tgtacacgtt gtcctcccac                                                   20


<210> 8616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 8616
tgacctgtga ccagacaagg                                                   20


<210> 8617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 8617
agacaaggga gagtgggaag                                                   20


<210> 8618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 8618
aagggagagt gggaaggagg                                                   20


<210> 8619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8619
gccaagccta agacatggac                                                   20


<210> 8620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8620
gggaggtgat ccaaggaagc                                                   20


<210> 8621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8621
atccaaggaa gcaggaatga                                                   20


<210> 8622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8622
gcaggaatga gggagtgggg                                                   20


<210> 8623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8623
gggagtgggg aagaataagc                                                   20


<210> 8624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8624
atgggagaag agcctgtgaa                                                   20


<210> 8625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 8625
caactgaagc gcaatcctac                                                   20


<210> 8626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8626
cgcaatccta ctggggtcct                                                   20


<210> 8627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 8627
gtaactgtgt agagcacatg                                                   20


<210> 8628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8628
tcaccaaggg acagggaaac                                                   20


<210> 8629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 8629
gactcccaaa acttattggt                                                   20


<210> 8630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8630
ctgcacaagc tcctaagccc                                                   20


<210> 8631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8631
agccctggag tctttataca                                                   20


<210> 8632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8632
ggctaaggga agaggtggca                                                   20


<210> 8633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 8633
tcttttcttt ttttttgaga                                                   20


<210> 8634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8634
tctcgctgtc tcgcccaagc                                                   20


<210> 8635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CCGGGT

<400> 8635
ctcactgcaa cttctgcctc                                                   20


<210> 8636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 8636
ctttcatatt ttagtagaga                                                   20


<210> 8637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 8637
acctcggcct cccaaagtgc                                                   20


<210> 8638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8638
accactgcgc ctggcccatc                                                   20


<210> 8639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8639
tttgctccca cccttgtcca                                                   20


<210> 8640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8640
ggaaaacctc gagaagcctg                                                   20


<210> 8641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8641
ggagggacag tgtgaggttg                                                   20


<210> 8642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 8642
gtgatcgcct cttccagtac                                                   20


<210> 8643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8643
catttcaaat gcagactgat                                                   20


<210> 8644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8644
caaatgcaga ctgatatggg                                                   20


<210> 8645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8645
tgggctgaga ctcacctccc                                                   20


<210> 8646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 8646
ggtggcccag tgagagagga                                                   20


<210> 8647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8647
ttggaaaggg cttgtgcaga                                                   20


<210> 8648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8648
gaatgaaagg aaaagttccc                                                   20


<210> 8649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8649
aatcccacat gtggctgttt                                                   20


<210> 8650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 8650
cacatgtggc tgtttaagaa                                                   20


<210> 8651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8651
attaaagaca cagagccttt                                                   20


<210> 8652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8652
aatgtagtat ggactgagga                                                   20


<210> 8653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8653
ccaccttatg cacatgatgt                                                   20


<210> 8654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8654
atcttccaga tggagaagtt                                                   20


<210> 8655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8655
gcattcttga ggtctagaaa                                                   20


<210> 8656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8656
tctgactgta tctcccaggg                                                   20


<210> 8657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8657
agctactcag agattatttg                                                   20


<210> 8658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8658
ataaatgcaa gaaccaatgg                                                   20


<210> 8659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8659
atggtggaat gtagacactc                                                   20


<210> 8660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8660
ataagtaatt gtattaacac                                                   20


<210> 8661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8661
acacttgaat gaacagagga                                                   20


<210> 8662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8662
caggtagatg aaggcaagaa                                                   20


<210> 8663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 8663
ggcaagaaat gagtgattga                                                   20


<210> 8664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 8664
gatgatgaaa gaaagaaaga                                                   20


<210> 8665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8665
atgaaagaaa gaaagacagg                                                   20


<210> 8666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8666
agcctcatgg tgtagtctgt                                                   20


<210> 8667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8667
tggtgtagtc tgtaggaata                                                   20


<210> 8668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8668
gagaatgacc tcagttcaca                                                   20


<210> 8669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8669
gacccagaag aagctgccag                                                   20


<210> 8670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8670
aagaagctgc cagtggagtt                                                   20


<210> 8671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8671
agacgaggag gacattcatg                                                   20


<210> 8672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8672
aggaggacat tcatgatgga                                                   20


<210> 8673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 8673
ccaatgcccc accccctctg                                                   20


<210> 8674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 8674
ctttggaaga agcaagagaa                                                   20


<210> 8675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8675
gagacattgg gcagctgaag                                                   20


<210> 8676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 8676
cttcttccct taacctcatt                                                   20


<210> 8677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 8677
ttcccttaac ctcattcagg                                                   20


<210> 8678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8678
gggtgggttg cagtgagaag                                                   20


<210> 8679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8679
gggttgcagt gagaagatgg                                                   20


<210> 8680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 8680
tactgcactc atttagaagt                                                   20


<210> 8681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8681
ttatttgtaa ataagcaaat                                                   20


<210> 8682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8682
agaatctatt agatacaaaa                                                   20


<210> 8683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TCGGGT

<400> 8683
atttcaaact atttcaatct                                                   20


<210> 8684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 8684
tttgtaatta tgaggaagag                                                   20


<210> 8685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 8685
caaggtggag gctgacagtg                                                   20


<210> 8686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 8686
tgacagtggt ggataaggaa                                                   20


<210> 8687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 8687
agtggtggat aaggaaaggg                                                   20


<210> 8688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 8688
aggagagaag aagcattcca                                                   20


<210> 8689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8689
tgagctgatg atgtcactca                                                   20


<210> 8690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8690
tcatggaaag acagagaact                                                   20


<210> 8691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 8691
gagatgttgg caataagagg                                                   20


<210> 8692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8692
gttggcaata agaggcagag                                                   20


<210> 8693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 8693
atgcttgtgg agcgatgatt                                                   20


<210> 8694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 8694
attacttcac taagagcaaa                                                   20


<210> 8695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8695
aagagcaaag ggggtgaggt                                                   20


<210> 8696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8696
tcctggtggc tgtaatattt                                                   20


<210> 8697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 8697
aagacttgaa agagaactaa                                                   20


<210> 8698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 8698
ggaggtgggg ccccggagct                                                   20


<210> 8699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8699
gccccggagc tcagggttgg                                                   20


<210> 8700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 8700
gatggagggc ataaaggggg                                                   20


<210> 8701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGAGT

<400> 8701
tttttgtttg ttttttgagg                                                   20


<210> 8702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8702
tctcgctctg tcacccaggc                                                   20


<210> 8703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 8703
ttttgtactt ttagcagaga                                                   20


<210> 8704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 8704
cagggtttcg gcatgttggc                                                   20


<210> 8705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8705
gcctcagcct cccaaagtgc                                                   20


<210> 8706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 8706
cgcagtggcc gcagagcgcg                                                   20


<210> 8707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8707
ggctttgatg ggagccactt                                                   20


<210> 8708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8708
ggagccactt cagaatattc                                                   20


<210> 8709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8709
gtgagactta tcagtgagat                                                   20


<210> 8710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8710
actccaatga gaggtctaga                                                   20


<210> 8711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 8711
tccctcctag gggctatgct                                                   20


<210> 8712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8712
tatgctgaga gtctattctg                                                   20


<210> 8713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8713
attctgagga atatagtaat                                                   20


<210> 8714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 8714
attatatttg ctcagagaag                                                   20


<210> 8715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8715
gctcagagaa gtggggtgga                                                   20


<210> 8716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8716
ggggtggaaa gaatagtggt                                                   20


<210> 8717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 8717
ggaaagaata gtggtttggg                                                   20


<210> 8718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8718
aaccctgatt ttttgtgagc                                                   20


<210> 8719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 8719
gggttagtgc ctggctagtc                                                   20


<210> 8720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8720
aaatgaaaaa gtcagactaa                                                   20


<210> 8721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8721
ttcttcaaaa agtttctggt                                                   20


<210> 8722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8722
gccacaccac agatggtggg                                                   20


<210> 8723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8723
agcttatcct ggcagttagg                                                   20


<210> 8724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 8724
agaaaagaag ggctttatac                                                   20


<210> 8725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8725
ccccaagcaa tgtccattct                                                   20


<210> 8726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8726
aagcaatgtc cattctttgg                                                   20


<210> 8727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGAAT

<400> 8727
attgcaccag gacaaagaac                                                   20


<210> 8728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8728
agcaggtgag acccagctgc                                                   20


<210> 8729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 8729
acccagctgc ctgggtgcat                                                   20


<210> 8730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8730
ccctgggaag tctgcctcac                                                   20


<210> 8731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 8731
cactggtact ttatcaccct                                                   20


<210> 8732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8732
ctaatgccac ctcccatagg                                                   20


<210> 8733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8733
attctcaacc accccacccc                                                   20


<210> 8734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 8734
agtgtaagat cctggagata                                                   20


<210> 8735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 8735
tatagcaaat ggaagaaaaa                                                   20


<210> 8736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8736
tggaagaaaa ataggatcat                                                   20


<210> 8737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 8737
aaagaaagaa agaagtacag                                                   20


<210> 8738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 8738
tacagctgga tgaaaagttg                                                   20


<210> 8739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8739
gttgaagggt gattgcatag                                                   20


<210> 8740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8740
aagggtgatt gcatagaggg                                                   20


<210> 8741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8741
ttgcatagag ggatgaatta                                                   20


<210> 8742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 8742
ttaaaggata caatgataaa                                                   20


<210> 8743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8743
ggatagattt aatgtataac                                                   20


<210> 8744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8744
gttttcagta tttttgctcg                                                   20


<210> 8745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8745
ctcttgccac agggggagaa                                                   20


<210> 8746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8746
atgggtaact atgtgagatg                                                   20


<210> 8747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8747
gtccccaccc aaatcttatc                                                   20


<210> 8748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 8748
agggaccctg tgggaggtaa                                                   20


<210> 8749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 8749
cccatgctgt tctcatgata                                                   20


<210> 8750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8750
gatgtgacgg tattataagg                                                   20


<210> 8751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8751
aagataacag acacaaaaag                                                   20


<210> 8752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 8752
aacagacaca aaaagatgga                                                   20


<210> 8753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8753
aagatggata ggatagatag                                                   20


<210> 8754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8754
taggatagat agttgaatgg                                                   20


<210> 8755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8755
aaaggaaaag tatgaaagca                                                   20


<210> 8756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 8756
aagtatgaaa gcagggaata                                                   20


<210> 8757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8757
atgaaagcag ggaatagtga                                                   20


<210> 8758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 8758
tgaatggata gatgagatag                                                   20


<210> 8759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8759
atgagatagg tggataagag                                                   20


<210> 8760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8760
gataggtgga taagagaagg                                                   20


<210> 8761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8761
gataagagaa ggatggatgg                                                   20


<210> 8762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8762
ctgggtaaaa tgactaatgc                                                   20


<210> 8763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8763
tggaaagatg gggagctgga                                                   20


<210> 8764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8764
tggggagctg gacagaatag                                                   20


<210> 8765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8765
agctggacag aatagatgaa                                                   20


<210> 8766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 8766
tagatgaatg gaataaatta                                                   20


<210> 8767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 8767
gtgaatgact ggaaggttga                                                   20


<210> 8768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8768
atgactggaa ggttgatagg                                                   20


<210> 8769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8769
ctggaaggtt gataggatgg                                                   20


<210> 8770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8770
aaggttgata ggatggatga                                                   20


<210> 8771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8771
ataggatgga tgaatggatg                                                   20


<210> 8772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8772
ggatgatgaa tggaagggaa                                                   20


<210> 8773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8773
gatgaatgga agggaaaggg                                                   20


<210> 8774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8774
acagataagt ggaagaaagg                                                   20


<210> 8775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8775
gtggaagaaa ggaagaatag                                                   20


<210> 8776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8776
atagatggat aggttgaaac                                                   20


<210> 8777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8777
aaacaagaat ggaaagatag                                                   20


<210> 8778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8778
aagaatggaa agatagaaga                                                   20


<210> 8779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 8779
atggaaagat agaagaatga                                                   20


<210> 8780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8780
atagaagaat gagtggatag                                                   20


<210> 8781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8781
aagaatgagt ggatagaagg                                                   20


<210> 8782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 8782
atgagtggat agaaggatga                                                   20


<210> 8783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8783
atgagtgagt agaagcatgc                                                   20


<210> 8784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 8784
catgcttgga tggaagatgc                                                   20


<210> 8785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8785
cttggatgga agatgcgtga                                                   20


<210> 8786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8786
aagatgcgtg aatgagtgaa                                                   20


<210> 8787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8787
aatgttagat gattggacag                                                   20


<210> 8788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8788
atgattggac agttggatag                                                   20


<210> 8789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8789
ttggacagtt ggatagaaga                                                   20


<210> 8790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 8790
atcaaaagat agaaagatat                                                   20


<210> 8791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8791
gatagaaaga tataagggtt                                                   20


<210> 8792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8792
agatataagg gttaaggatg                                                   20


<210> 8793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8793
tgaatagatg gaaggaagtt                                                   20


<210> 8794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8794
gcagaagaga agagggaaag                                                   20


<210> 8795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8795
gagaagaggg aaagaagaat                                                   20


<210> 8796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8796
agagggaaag aagaatggga                                                   20


<210> 8797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8797
ggaaagaaga atgggaatgg                                                   20


<210> 8798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8798
tacagctgga agaaataaag                                                   20


<210> 8799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8799
gctggaagaa ataaagatgg                                                   20


<210> 8800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8800
ggaggaagga aaaaggaaga                                                   20


<210> 8801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8801
gaaaaaggaa gactgaatgg                                                   20


<210> 8802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8802
aaggtgaaat gtatggaagg                                                   20


<210> 8803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8803
tgaaatgtat ggaaggaagg                                                   20


<210> 8804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8804
aaggatggat ggttggaagg                                                   20


<210> 8805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8805
aaggaagaat cagtaggaag                                                   20


<210> 8806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8806
tcagtaggaa gatggatgaa                                                   20


<210> 8807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 8807
ctggtgagat caacataagc                                                   20


<210> 8808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 8808
aggagtgact gtgcccccaa                                                   20


<210> 8809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGAAT

<400> 8809
cccccaaagg ggtgggacac                                                   20


<210> 8810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8810
aaataatttt cctttcattt                                                   20


<210> 8811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8811
gaataattat ttcatatgca                                                   20


<210> 8812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8812
gcattggcat cagggaagaa                                                   20


<210> 8813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8813
ggcatcaggg aagaagagaa                                                   20


<210> 8814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8814
tgccagcaca ggaggctgga                                                   20


<210> 8815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 8815
accttgctgc tggcagctgc                                                   20


<210> 8816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8816
agatgaggaa gagatgactg                                                   20


<210> 8817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8817
cacagtcaat tctctaatgc                                                   20


<210> 8818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8818
attactggcc acaggttacc                                                   20


<210> 8819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8819
ccacccaaga ccaataagat                                                   20


<210> 8820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 8820
accaataaga tcagaatctc                                                   20


<210> 8821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8821
aaggtccaga agacccatct                                                   20


<210> 8822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8822
gctgcatgtg tcatctcact                                                   20


<210> 8823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8823
actttggatg taaaaatgca                                                   20


<210> 8824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8824
gtaaaaatgc agaggattgc                                                   20


<210> 8825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8825
agaggattgc agggatcttt                                                   20


<210> 8826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8826
ctgcctggac tttaccactc                                                   20


<210> 8827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8827
aaatgctcaa aacttttctt                                                   20


<210> 8828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 8828
cctttgccct agctgtagcc                                                   20


<210> 8829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8829
tcaaaggcct ggaaggaaga                                                   20


<210> 8830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8830
cctggaagga agaaaggatg                                                   20


<210> 8831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 8831
cctgaccaca gtccctggaa                                                   20


<210> 8832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8832
tttgctgtgg ggaggtaaag                                                   20


<210> 8833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8833
acagccctgc tgatacttgc                                                   20


<210> 8834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8834
tgctgatact tgcagggatg                                                   20


<210> 8835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8835
agaaagaaaa ccttctcaaa                                                   20


<210> 8836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8836
ggattttgga agtgaaccaa                                                   20


<210> 8837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ACGGAT

<400> 8837
gtttaaaaat aaaagcatca                                                   20


<210> 8838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8838
cagtttacaa aaatgaaagt                                                   20


<210> 8839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8839
tcgccaacac acctctgaaa                                                   20


<210> 8840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8840
tcagactggt ggagatggaa                                                   20


<210> 8841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 8841
gaaaagaata ggggaaaccc                                                   20


<210> 8842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGAGT

<400> 8842
tttttttttt ttttttgaga                                                   20


<210> 8843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8843
tctcgctctg tcgcccaggc                                                   20


<210> 8844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGGAT

<400> 8844
cccaggctgg agtgcagtag                                                   20


<210> 8845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGGGT

<400> 8845
ttttgtattt ttagtagaga                                                   20


<210> 8846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGGAT

<400> 8846
cggggtttca ccgttttagc                                                   20


<210> 8847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8847
gcctcagcct cccaaagtgc                                                   20


<210> 8848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 8848
cactcttaca agtgactggc                                                   20


<210> 8849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8849
gcccctatcc ttcatctgct                                                   20


<210> 8850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8850
gtgtcggctg ctaatagttc                                                   20


<210> 8851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 8851
tcagccaggg acagtgacag                                                   20


<210> 8852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8852
ttgtgcttca gggctttcca                                                   20


<210> 8853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CCGGAT

<400> 8853
ttccatggga tcagctgaag                                                   20


<210> 8854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8854
agattatcca acgtctctaa                                                   20


<210> 8855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8855
tctctaaggg agtacacaca                                                   20


<210> 8856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 8856
gaagtaaaca tagagattgg                                                   20


<210> 8857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8857
attggttgag taaattataa                                                   20


<210> 8858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8858
agaaaaatgt actgaggtta                                                   20


<210> 8859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 8859
gtataccagc atgttttcaa                                                   20


<210> 8860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 8860
gttttcaagt gagtttctct                                                   20


<210> 8861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8861
tctctttgag tgatagggaa                                                   20


<210> 8862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8862
gcaggtctga gcttcctcct                                                   20


<210> 8863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 8863
agcttcctcc tgggaatgtg                                                   20


<210> 8864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGGGT

<400> 8864
tgggaatgtg gggggtggac                                                   20


<210> 8865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 8865
cacacagttc cccctccacc                                                   20


<210> 8866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 8866
tatttagtag gttgttttta                                                   20


<210> 8867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8867
aatgacacat gaggcgcaag                                                   20


<210> 8868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 8868
tgagtgaaaa cactgcagcc                                                   20


<210> 8869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8869
tttagaaaat gcaaacaact                                                   20


<210> 8870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGAGT

<400> 8870
tgtctacctt ggtctattgg                                                   20


<210> 8871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8871
cttagagatg tctcccaact                                                   20


<210> 8872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 8872
aaggccttgt tattcaaagt                                                   20


<210> 8873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8873
caggccctgc cacagattta                                                   20


<210> 8874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8874
ctgccacaga tttatggaat                                                   20


<210> 8875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 8875
tgattttctg tgagctttaa                                                   20


<210> 8876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 8876
gccgtgtgtt ggggaggtca                                                   20


<210> 8877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGGAT

<400> 8877
gggtgggaag ccaggggctt                                                   20


<210> 8878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8878
gggattaaat aagggcaaag                                                   20


<210> 8879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8879
tgggttttgc tactgacaag                                                   20


<210> 8880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 8880
ggacaagcct tttaaacatt                                                   20


<210> 8881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8881
ctgatgcagc tccagggcct                                                   20


<210> 8882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8882
ttgtaggaga ttcctatctg                                                   20


<210> 8883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 8883
accagagatc cactgctgag                                                   20


<210> 8884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GCGAAT

<400> 8884
agtttgcagc agggacagtg                                                   20


<210> 8885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 8885
gtggggagag gtgactgatg                                                   20


<210> 8886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 8886
ggtgatggcc agtgggcaaa                                                   20


<210> 8887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8887
cttggaaaaa aattctttcc                                                   20


<210> 8888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 8888
aaaaaattct ttcctggaat                                                   20


<210> 8889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 8889
ttcctggaat atgggtgaag                                                   20


<210> 8890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8890
gtgaagaggg gtcccttcca                                                   20


<210> 8891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 8891
aagctacggc gtatgagcct                                                   20


<210> 8892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 8892
tgagcctggg ggtgcctgag                                                   20


<210> 8893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8893
actgagggcc acgacgtggc                                                   20


<210> 8894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 8894
ggccacgacg tggctgggat                                                   20


<210> 8895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 8895
cgacgtggct gggatgggga                                                   20


<210> 8896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 8896
cagcccagct cagcccagcc                                                   20


<210> 8897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 8897
tgaggccaca attcccttta                                                   20


<210> 8898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8898
tcattgcaca aatatttatt                                                   20


<210> 8899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8899
agatacatca tggccttcct                                                   20


<210> 8900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8900
ggtccttcat ggtccaaatc                                                   20


<210> 8901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 8901
ggctggttta gaactcacgg                                                   20


<210> 8902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 8902
gaactcacgg aggggttttt                                                   20


<210> 8903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8903
atgcgggcgc cctcaagcct                                                   20


<210> 8904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 8904
gcacagcttg tttgtcttct                                                   20


<210> 8905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 8905
ttgtcttctg tggatcccag                                                   20


<210> 8906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 8906
ccaggtgagt gttcgctcaa                                                   20


<210> 8907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8907
tccaggtcat ctgccagctc                                                   20


<210> 8908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 8908
gccagctcag ggatcttcct                                                   20


<210> 8909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 8909
gatcttcctc aggatttcct                                                   20


<210> 8910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8910
tcgtctctcc gcggggcccg                                                   20


<210> 8911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8911
taaaccttcg gggcccctga                                                   20


<210> 8912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8912
actctcagca ttcactgggc                                                   20


<210> 8913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8913
tgggcttgaa tatttaatca                                                   20


<210> 8914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8914
cagccctata atgtctccag                                                   20


<210> 8915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 8915
gtctccagat gaattcaatt                                                   20


<210> 8916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GCGGGT

<400> 8916
taatggaccc aaatggtggg                                                   20


<210> 8917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGGGT

<400> 8917
tcaggcccct cctgcctagc                                                   20


<210> 8918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 8918
gaagttgtgt actgaaaaca                                                   20


<210> 8919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8919
gagtagggac aactagccag                                                   20


<210> 8920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 8920
agaagcatga catccacgtg                                                   20


<210> 8921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 8921
ctgaagggct tgataacttt                                                   20


<210> 8922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8922
agggcttgat aactttgggg                                                   20


<210> 8923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8923
ctaggtgtca aattaaattc                                                   20


<210> 8924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 8924
gtggacaaaa gaaagtgggg                                                   20


<210> 8925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8925
attaccattc agtttcatag                                                   20


<210> 8926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8926
atcttaggtc ccacagcttg                                                   20


<210> 8927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8927
ttctatacct agaaccaccc                                                   20


<210> 8928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GCGGAT

<400> 8928
atggtgaaag ttgaaattgt                                                   20


<210> 8929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 8929
ggagggactt taaaaattcc                                                   20


<210> 8930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 8930
taagaaatga ggttatgtga                                                   20


<210> 8931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8931
ttatgtgatt gagtgcagtc                                                   20


<210> 8932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8932
catctttcca cgtctcaccc                                                   20


<210> 8933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8933
atgttccagt gcctgggctc                                                   20


<210> 8934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 8934
agctgctcct gctagtgaga                                                   20


<210> 8935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8935
ctagtgagag agggtcccaa                                                   20


<210> 8936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8936
atgaccagtt ctaaatttga                                                   20


<210> 8937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8937
catcacaggc tgccagagcc                                                   20


<210> 8938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8938
caaagtaact gaaaatgctt                                                   20


<210> 8939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 8939
tgagtggcag acagctgtca                                                   20


<210> 8940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 8940
tgcatgttcc tgaggcctca                                                   20


<210> 8941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 8941
ccttcccacg ttgggcagag                                                   20


<210> 8942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8942
gttgggcaga ggtgaatgcc                                                   20


<210> 8943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 8943
gttactgaga agaggttagc                                                   20


<210> 8944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8944
tataccagct taaggtagta                                                   20


<210> 8945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8945
tgtggggaaa agctggctaa                                                   20


<210> 8946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 8946
gctggctaaa tgagtcacat                                                   20


<210> 8947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 8947
acataagaat caggacttct                                                   20


<210> 8948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 8948
tagcatctca tgcacagagc                                                   20


<210> 8949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8949
actccctgtt tgtctgcctg                                                   20


<210> 8950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 8950
actgcctgtg gctgtccctt                                                   20


<210> 8951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 8951
ataactctta cctgtccttt                                                   20


<210> 8952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TCGGAT

<400> 8952
gggcacagag acccacacag                                                   20


<210> 8953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 8953
ggttctcagc cttggagctg                                                   20


<210> 8954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 8954
cagccttgga gctggagagt                                                   20


<210> 8955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8955
caggctctgc cttgggctgg                                                   20


<210> 8956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 8956
ttggtacgat ggccaaagac                                                   20


<210> 8957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8957
tgtgaggttg tcagcactga                                                   20


<210> 8958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 8958
aggttaagca cctgaagaga                                                   20


<210> 8959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CCGGGT

<400> 8959
ctgagcccca cattggccta                                                   20


<210> 8960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGGAT

<400> 8960
tgggcctctt cctgcccacc                                                   20


<210> 8961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 8961
cgggatgctg tcccttttgg                                                   20


<210> 8962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 8962
gagcagttga gggaaagttt                                                   20


<210> 8963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8963
gggaaagttt ggggatgtcc                                                   20


<210> 8964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 8964
ctgggctctg ttcctgactc                                                   20


<210> 8965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 8965
agaaatgtaa aagtgctcag                                                   20


<210> 8966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 8966
gaggggtaaa cttcctgtct                                                   20


<210> 8967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 8967
aggggcatct gtggctctgc                                                   20


<210> 8968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 8968
gtgggctcag cctggaagaa                                                   20


<210> 8969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 8969
gcctggaaga acagagtttc                                                   20


<210> 8970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 8970
ggcatccctg gctcaggcac                                                   20


<210> 8971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8971
caccagggtg gaaaagacta                                                   20


<210> 8972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 8972
ggtggaaaag actaaagagt                                                   20


<210> 8973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 8973
ggcaaggacc ccaccatgac                                                   20


<210> 8974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 8974
aggaccccac catgaccaga                                                   20


<210> 8975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 8975
gggccaggct ggggcggaga                                                   20


<210> 8976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 8976
gtattggggc ttattggcaa                                                   20


<210> 8977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 8977
agaggggctt cctccaaaca                                                   20


<210> 8978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 8978
ttgttattat ttctgtggcc                                                   20


<210> 8979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8979
atcagtcagc tcttacttcc                                                   20


<210> 8980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 8980
cagctaatag acaccgttta                                                   20


<210> 8981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8981
ttaattctcc cagtaaaccc                                                   20


<210> 8982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 8982
aggagattaa gtctcttgcc                                                   20


<210> 8983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8983
cccaaggcac acttcttgta                                                   20


<210> 8984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 8984
cttcttgtaa tgaatcccac                                                   20


<210> 8985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 8985
ccaggagaca gtgcccccag                                                   20


<210> 8986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 8986
agcaccatca ccgtcaagaa                                                   20


<210> 8987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 8987
tcaagaaaag gatgaggcat                                                   20


<210> 8988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 8988
ttctcaatcc actctccaca                                                   20


<210> 8989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 8989
gatacggaag acaatgagga                                                   20


<210> 8990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 8990
aagacaaaga caatgatggc                                                   20


<210> 8991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8991
gaggttcccc agtgccccca                                                   20


<210> 8992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 8992
ctgagtttcc gatgatcttg                                                   20


<210> 8993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 8993
tgagtgtgtt taaggtgggc                                                   20


<210> 8994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 8994
tgggccagga tttggccagc                                                   20


<210> 8995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 8995
atgtgcttca ttgactgtgg                                                   20


<210> 8996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 8996
ttcattgact gtggctgagt                                                   20


<210> 8997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 8997
gctgagtcag ggtcttctac                                                   20


<210> 8998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 8998
agccacaggc ctgatccctc                                                   20


<210> 8999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 8999
atgggcctct tctgtggagg                                                   20


<210> 9000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 9000
gcctcttctg tggaggtggg                                                   20


<210> 9001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TCGGGT

<400> 9001
tgaagagaga ccagcctcct                                                   20


<210> 9002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 9002
agaccagcct ccttcgggta                                                   20


<210> 9003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9003
ccaggctgtg gcttaggtgc                                                   20


<210> 9004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 9004
caattttatc acccatatcc                                                   20


<210> 9005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GCGGGT

<400> 9005
tctttatgtg atgggggaga                                                   20


<210> 9006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9006
ccgaaggttg taagcctagc                                                   20


<210> 9007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9007
aagagctata cccttcatgt                                                   20


<210> 9008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9008
tgaaccacaa acaatcccag                                                   20


<210> 9009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9009
ccaggagaat gcaaggaaaa                                                   20


<210> 9010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9010
acaacaaagt ggtgctcata                                                   20


<210> 9011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9011
tgctcatata ggattttatc                                                   20


<210> 9012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9012
ctacctaggt attttaagtt                                                   20


<210> 9013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9013
caattctaca aagtgctctg                                                   20


<210> 9014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9014
tattccctca aaaattgttt                                                   20


<210> 9015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9015
aaaaaacaaa caaaaacaga                                                   20


<210> 9016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9016
aacaaacaaa aacagaagga                                                   20


<210> 9017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9017
aacagaagga atgagtcatc                                                   20


<210> 9018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9018
gaaggaatga gtcatcaaga                                                   20


<210> 9019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9019
cattccattt cttcagatga                                                   20


<210> 9020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9020
ataacttgaa actatgtgca                                                   20


<210> 9021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9021
agatttgaca cagtttggga                                                   20


<210> 9022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9022
tgggagagaa ttagtgaact                                                   20


<210> 9023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9023
ttagtgaact gaggatatat                                                   20


<210> 9024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9024
atatatcaga ataaattatt                                                   20


<210> 9025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9025
aaaatagtgt aagagacata                                                   20


<210> 9026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9026
agtgtaagag acatagagga                                                   20


<210> 9027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9027
agacatagag gatagaatga                                                   20


<210> 9028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9028
aagtccagaa ggagaaaaaa                                                   20


<210> 9029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9029
catcatgtct gggaactttc                                                   20


<210> 9030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 9030
gaaactgcag aacaccaaag                                                   20


<210> 9031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9031
taaaaagcat ccagaaagga                                                   20


<210> 9032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9032
caacaatgga ggctaattgt                                                   20


<210> 9033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9033
aaggaagata aagtatcaac                                                   20


<210> 9034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9034
atatgtaatg tgtaatatac                                                   20


<210> 9035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 9035
gaatgtgaaa ctgtgctcca                                                   20


<210> 9036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 9036
taactaaatt tttaggctta                                                   20


<210> 9037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9037
gaaactcaaa ctgtgttcca                                                   20


<210> 9038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 9038
tcagtaactt acaaaaattc                                                   20


<210> 9039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9039
tacaaaaatt cttgagtttt                                                   20


<210> 9040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 9040
aggctgaaat caattggaac                                                   20


<210> 9041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9041
ttggaaccag gatggccgac                                                   20


<210> 9042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9042
atggccgact ggagtttgtg                                                   20


<210> 9043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9043
gagcttgctg acgtcatgga                                                   20


<210> 9044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9044
cagatttgca tatgcaaccc                                                   20


<210> 9045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9045
agcaagaaag tgctaagcat                                                   20


<210> 9046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9046
agaaagtgct aagcatgaga                                                   20


<210> 9047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 9047
agagtgaatc taaataaaca                                                   20


<210> 9048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9048
cagttttgct tgcaaatagt                                                   20


<210> 9049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 9049
aaatagttgg ggtcatgtta                                                   20


<210> 9050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9050
tgttagtggg ttctgtctgg                                                   20


<210> 9051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9051
aagatggtga catcacgata                                                   20


<210> 9052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9052
ggagagcttc ccaacaagca                                                   20


<210> 9053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 9053
tatgttaact cacagattta                                                   20


<210> 9054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 9054
tgcagctagt tgtacttatc                                                   20


<210> 9055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9055
gaagctgata ggagaaggct                                                   20


<210> 9056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 9056
tgaaccagca accctagggg                                                   20


<210> 9057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 9057
gtttattaaa ccttagtatt                                                   20


<210> 9058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9058
gaaagattta gctggtttat                                                   20


<210> 9059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9059
agattccagg cagtgagcaa                                                   20


<210> 9060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9060
ggcatggcaa agtcacttct                                                   20


<210> 9061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ACGAGT

<400> 9061
ggcttgcatt aggctatgat                                                   20


<210> 9062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9062
agtgagaaat aaacctttat                                                   20


<210> 9063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9063
atcattacaa taaattggga                                                   20


<210> 9064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9064
ataaattggg aaaggatatc                                                   20


<210> 9065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9065
tttgattaag ttaactaatg                                                   20


<210> 9066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9066
ttatttattt atttttgaga                                                   20


<210> 9067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9067
tttgcccttg ttgcccaggc                                                   20


<210> 9068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CCGGGT

<400> 9068
ctcaccgcaa cctccgcctc                                                   20


<210> 9069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9069
ccctcagcct cccaagtagc                                                   20


<210> 9070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 9070
attttgtatt tttggtagag                                                   20


<210> 9071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9071
gcctgcgcct ccaacagtgc                                                   20


<210> 9072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGAGT

<400> 9072
ttttattgtt ttcaatgaga                                                   20


<210> 9073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9073
tctcgctctg ttgcccaggc                                                   20


<210> 9074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9074
ctcactgcaa cctctgtctc                                                   20


<210> 9075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9075
aattctcatg cctcaccctc                                                   20


<210> 9076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9076
gcctcaccct cctgagtagc                                                   20


<210> 9077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9077
ttatatattt ttagtagaga                                                   20


<210> 9078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9078
accttggcct cccaaaattc                                                   20


<210> 9079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 9079
atcaaatatt actcattgat                                                   20


<210> 9080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9080
gatcaagcta ggtttgagct                                                   20


<210> 9081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9081
catgattatc tcaatacatg                                                   20


<210> 9082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9082
tagaggtggt gaaatattga                                                   20


<210> 9083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9083
aatattgaaa ggattctttt                                                   20


<210> 9084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9084
cacttctttt caacagtgta                                                   20


<210> 9085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9085
taaaaagaac ctaatggcat                                                   20


<210> 9086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 9086
aagaagaaat taggctgggc                                                   20


<210> 9087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9087
ccgtctctac taaaaataca                                                   20


<210> 9088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 9088
agaattagcc aggcatggtg                                                   20


<210> 9089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9089
tactcaggag gctgaggcag                                                   20


<210> 9090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9090
tcacgccact gcactctagc                                                   20


<210> 9091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9091
acattgtata gataaattat                                                   20


<210> 9092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9092
tatcttcata gatcagaaga                                                   20


<210> 9093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 9093
aatagcagtt ttgtgtgtat                                                   20


<210> 9094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9094
cttggcaaga taattctaaa                                                   20


<210> 9095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 9095
atattcttga agtaaattag                                                   20


<210> 9096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 9096
attaagactg atattggtgc                                                   20


<210> 9097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 9097
aatcaatcaa caggtgttta                                                   20


<210> 9098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9098
tgggccttgt gctaggccct                                                   20


<210> 9099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9099
aaactctggt ttttgcctca                                                   20


<210> 9100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9100
atgccaggtt aatttgatga                                                   20


<210> 9101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 9101
ggtgacaagt gcattgaaca                                                   20


<210> 9102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9102
gtgcattgaa cacagagttt                                                   20


<210> 9103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9103
tctgttatgt gtgaagaaga                                                   20


<210> 9104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 9104
gaactttgta caccatcatg                                                   20


<210> 9105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9105
tgtacaccat catgaggagt                                                   20


<210> 9106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9106
gtgtgtgtgt gtgtgtgttg                                                   20


<210> 9107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 9107
gaggcagagg gaaaaggtga                                                   20


<210> 9108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9108
aagctaggtc atgagggaag                                                   20


<210> 9109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 9109
cccaagaaag tgtgtagttg                                                   20


<210> 9110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9110
gtagttggtg ggtgtggtta                                                   20


<210> 9111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 9111
ttaaatcagc gaggtgggga                                                   20


<210> 9112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9112
gacagggtag cattcccctg                                                   20


<210> 9113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9113
ttgtttggga ctttagactg                                                   20


<210> 9114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGAGT

<400> 9114
tttttttttt ttttttgaga                                                   20


<210> 9115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CCGGAT

<400> 9115
gtcccgctgt ttagcccagg                                                   20


<210> 9116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CCGAGT

<400> 9116
cattctcctg cctcagcctc                                                   20


<210> 9117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGGGT

<400> 9117
ttttgtattt ttagtagaga                                                   20


<210> 9118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9118
gcctcggcct cccaaagtgc                                                   20


<210> 9119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 9119
aaaactaact gtgggcctgc                                                   20


<210> 9120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 9120
ctgtgggcct gccagggtat                                                   20


<210> 9121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 9121
ccttgtaaga ttttcaagtt                                                   20


<210> 9122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9122
agattttcaa gttatggata                                                   20


<210> 9123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9123
tactctaccc ttctcctccc                                                   20


<210> 9124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 9124
gacatgcttt atttggtctt                                                   20


<210> 9125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9125
ctttagagtg tttttaaaaa                                                   20


<210> 9126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9126
aaagacattt gcacaaaaat                                                   20


<210> 9127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9127
tcttactctg tctcccaggc                                                   20


<210> 9128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9128
gatcctccca cctcagtctt                                                   20


<210> 9129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9129
acctcagtct tctgagtagc                                                   20


<210> 9130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGGGT

<400> 9130
tttttcattt tttgtagaga                                                   20


<210> 9131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9131
gcctcggcct cccaaagtac                                                   20


<210> 9132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 9132
tctatgtaaa catccctccc                                                   20


<210> 9133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 9133
cccaggagtt gtgcactgct                                                   20


<210> 9134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9134
ttgggtctgc ctaggtgaaa                                                   20


<210> 9135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 9135
atgtcactgc acatgggcat                                                   20


<210> 9136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 9136
tgtctcactg gcccctgtga                                                   20


<210> 9137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 9137
ggtcccaagc agatctgtcc                                                   20


<210> 9138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9138
ccatgcaccc ccttcaacct                                                   20


<210> 9139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9139
tcaggacctt gggaagattg                                                   20


<210> 9140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9140
caggcctctt tcctattccc                                                   20


<210> 9141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9141
cctagtgacc cgacactcct                                                   20


<210> 9142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 9142
aacctgtggc tctgataaaa                                                   20


<210> 9143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9143
ctgtagaggg cgtcctggag                                                   20


<210> 9144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 9144
gagaagagcc atcattgcat                                                   20


<210> 9145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9145
ggctgtgatt tcgggcacaa                                                   20


<210> 9146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9146
tttcgggcac aagggaatca                                                   20


<210> 9147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9147
gctggaagga gctggggctc                                                   20


<210> 9148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9148
gggctctgga gtcagacaac                                                   20


<210> 9149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TCGGGT

<400> 9149
gcttggcaga tgggagactt                                                   20


<210> 9150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9150
ctttttcctc acccacccct                                                   20


<210> 9151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 9151
tcttaaaaac gactatctct                                                   20


<210> 9152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9152
ggagaaggca tgtccccact                                                   20


<210> 9153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 9153
acccaagtct ccagtcgccc                                                   20


<210> 9154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9154
cccagagcac agtgtcttcc                                                   20


<210> 9155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9155
gcacagtgtc ttccctgaat                                                   20


<210> 9156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 9156
tgtcttccct gaatctgggt                                                   20


<210> 9157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 9157
cttcttctgg aaataatagt                                                   20


<210> 9158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 9158
aaaaaatatg gtaaagacct                                                   20


<210> 9159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9159
gaaacaagct ttcatcacag                                                   20


<210> 9160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9160
tttcatcaca gtgggatctg                                                   20


<210> 9161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9161
tatgttatct gtgggctcct                                                   20


<210> 9162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 9162
gtgggctcct gaggattggc                                                   20


<210> 9163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9163
cagggtaaca gtcaacgtga                                                   20


<210> 9164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9164
gcatgctgca gtttttccac                                                   20


<210> 9165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 9165
ttttccacgt gaatggtggt                                                   20


<210> 9166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9166
cacgtgaatg gtggtgggag                                                   20


<210> 9167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GCGGAT

<400> 9167
tggtggtggg agtggaataa                                                   20


<210> 9168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9168
ataatatcat tttgtcagtg                                                   20


<210> 9169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 9169
tggttcagta gttaaaacgt                                                   20


<210> 9170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9170
ggttgtggga catcacagac                                                   20


<210> 9171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9171
tctaattgtc ttaaatagga                                                   20


<210> 9172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TCGGGT

<400> 9172
gagagaggtc agaaccaggc                                                   20


<210> 9173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 9173
agaaggagga aagcaacgac                                                   20


<210> 9174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9174
tatggagaag aaaacaggct                                                   20


<210> 9175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9175
catgccacaa gactgattca                                                   20


<210> 9176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9176
actgattcaa agagtatcta                                                   20


<210> 9177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 9177
caagtcagtg tggtgtggtg                                                   20


<210> 9178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 9178
cagtgtggtg tggtgggggg                                                   20


<210> 9179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9179
gtcttgtgtc ttccagagac                                                   20


<210> 9180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9180
tccagagacc tgggtccacc                                                   20


<210> 9181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 9181
accagctata caattttggg                                                   20


<210> 9182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9182
gggcaggata tttaacctct                                                   20


<210> 9183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 9183
agtgctctct tttgtcatgt                                                   20


<210> 9184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9184
tgcttccact tttctaactg                                                   20


<210> 9185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 9185
cacttttcta actgtagaat                                                   20


<210> 9186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9186
tggtcttagg ctgacttctt                                                   20


<210> 9187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9187
tttccttttc atatcaactt                                                   20


<210> 9188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9188
ctgctgcccc tttcacagcc                                                   20


<210> 9189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 9189
cagccctgga ttatggcgga                                                   20


<210> 9190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9190
cccaaagcca gacagttctg                                                   20


<210> 9191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 9191
ccctgctgcg gacatgaagg                                                   20


<210> 9192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 9192
cttgtgaggt ggcttaattc                                                   20


<210> 9193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9193
gggcttggca gccggtctgt                                                   20


<210> 9194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9194
ccatttttcc atctgggaaa                                                   20


<210> 9195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9195
catctgggaa agggaataac                                                   20


<210> 9196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 9196
taacaagagt gcctaccatg                                                   20


<210> 9197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9197
agataatcca tgagaagcat                                                   20


<210> 9198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 9198
tgagtattat tactattcct                                                   20


<210> 9199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9199
ttggagcagt tgttgtccct                                                   20


<210> 9200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 9200
agtatatagt gaaatccagt                                                   20


<210> 9201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9201
agtatggatt gtatcttgtt                                                   20


<210> 9202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9202
gccattccca ccagctcagc                                                   20


<210> 9203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 9203
ggtgatggtg agctctgcaa                                                   20


<210> 9204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9204
ggatccgtca caagcccaaa                                                   20


<210> 9205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 9205
tctgagacaa gctggtcaag                                                   20


<210> 9206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TCGAGT

<400> 9206
ggcacttctg ttcagactcc                                                   20


<210> 9207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9207
tgcctggcaa aacctgaact                                                   20


<210> 9208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9208
gagctccctt ttatttcact                                                   20


<210> 9209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 9209
cttcgtgccc cacacagtgc                                                   20


<210> 9210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9210
ttgacagtaa aattccttgc                                                   20


<210> 9211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9211
ctttttttct ctgcagcccc                                                   20


<210> 9212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9212
cttaccctta taacatttga                                                   20


<210> 9213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9213
tcctttcctg cttgtaaatg                                                   20


<210> 9214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9214
accttagctt ctctgtgttt                                                   20


<210> 9215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 9215
tgcctccgtt aaatctccat                                                   20


<210> 9216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9216
aagcataata cattgtgaaa                                                   20


<210> 9217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9217
tatgcataga acattgcttg                                                   20


<210> 9218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9218
ttgaagaata taagataaac                                                   20


<210> 9219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 9219
aagataaact ggagtgggag                                                   20


<210> 9220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 9220
gagtgggagg ggggtgcacc                                                   20


<210> 9221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 9221
ccaggagtct ggggagcagg                                                   20


<210> 9222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 9222
gcatacacac ttgcagtgtt                                                   20


<210> 9223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 9223
ttaaattata ctttaagttt                                                   20


<210> 9224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 9224
tggtgcattt gaaatttatt                                                   20


<210> 9225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9225
tttgaaattt attttgggta                                                   20


<210> 9226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9226
atttatatca acattactta                                                   20


<210> 9227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9227
catgctgttt taatcactga                                                   20


<210> 9228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9228
aagaagcaca ggaagtagtc                                                   20


<210> 9229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9229
tgaccatggc cccacctcaa                                                   20


<210> 9230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 9230
gcattctctc ctgccactgc                                                   20


<210> 9231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9231
cctgccactg caggagtctg                                                   20


<210> 9232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9232
ttccttttca gtctcctctg                                                   20


<210> 9233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9233
tcccctaaaa tgctcccttt                                                   20


<210> 9234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9234
accatatgca tcatcaagtc                                                   20


<210> 9235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 9235
cagccccact gtcactaccc                                                   20


<210> 9236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 9236
ctcttatatc tacaagtatc                                                   20


<210> 9237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 9237
ccatatcctt aatgcagtct                                                   20


<210> 9238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9238
aatgcagtct aggagtttct                                                   20


<210> 9239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9239
gctttgcagt cctttcagcc                                                   20


<210> 9240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9240
cactgctgtg acccagcttc                                                   20


<210> 9241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 9241
gcatagaagg ttcacatgct                                                   20


<210> 9242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9242
gttcacatgc tttgagttca                                                   20


<210> 9243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9243
tcaggtgtct catgtgtgta                                                   20


<210> 9244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9244
tttgtgcatg cacttgtctt                                                   20


<210> 9245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9245
aatcataata gccaaatgtg                                                   20


<210> 9246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9246
tgtaccataa gtggaagagc                                                   20


<210> 9247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CCGGGT

<400> 9247
taggatgcaa acccaggcag                                                   20


<210> 9248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9248
ttcttttgtc ttacctacac                                                   20


<210> 9249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9249
ttgttgctat ctcattcttg                                                   20


<210> 9250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9250
aaatttctgt tcttcttgga                                                   20


<210> 9251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9251
ttttctccta cttcttatat                                                   20


<210> 9252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9252
tttcatgtcc ccttccctgc                                                   20


<210> 9253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9253
aagcttatat cagttcacca                                                   20


<210> 9254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9254
caacaaatgc ttgttgataa                                                   20


<210> 9255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9255
gaggaagctt aacagttttc                                                   20


<210> 9256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9256
ctggccaaga aagaaattgt                                                   20


<210> 9257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9257
aatgagaaaa aataatagaa                                                   20


<210> 9258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9258
gtacacgttg ttgttgagaa                                                   20


<210> 9259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9259
atgcaagaaa tgtaacttag                                                   20


<210> 9260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 9260
tgtctcttgt taagtcaatg                                                   20


<210> 9261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9261
gttgggtact atttcaatat                                                   20


<210> 9262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9262
ttcaatatct gagtctgtgt                                                   20


<210> 9263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9263
tgtagggctc aaacctggag                                                   20


<210> 9264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9264
cattgctaag cgtattttgc                                                   20


<210> 9265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9265
tcccatctgg tccctggtgg                                                   20


<210> 9266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 9266
tctctctcta gtttccctct                                                   20


<210> 9267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9267
actctacagt ttctgtgcat                                                   20


<210> 9268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9268
accacttctt cccctcaaat                                                   20


<210> 9269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 9269
ggtcagttta atttgtctag                                                   20


<210> 9270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9270
taccctaagg caaaaaaagg                                                   20


<210> 9271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 9271
gacctcctgc tcaaggttag                                                   20


<210> 9272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 9272
cacgctctat ggcaaagtgt                                                   20


<210> 9273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9273
tagatacatt gctggggaga                                                   20


<210> 9274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 9274
tacattgctg gggagactga                                                   20


<210> 9275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9275
gtggattccc acttgattgg                                                   20


<210> 9276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9276
tataattatg aaaccatgaa                                                   20


<210> 9277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9277
ttttgccatg ttggaaaatt                                                   20


<210> 9278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9278
aatttgaaca agagatgagc                                                   20


<210> 9279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9279
gatggtgggg cctaagacat                                                   20


<210> 9280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 9280
gggcctaaga cataagaatg                                                   20


<210> 9281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9281
acataagaat gaggagtatt                                                   20


<210> 9282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ACGAGT

<400> 9282
acagagatgg acgctttgac                                                   20


<210> 9283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9283
attgcttctg ctgctcacat                                                   20


<210> 9284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 9284
tgggaattca tcatgacaca                                                   20


<210> 9285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TCGAAT

<400> 9285
aagtcttctt ttgtcctgca                                                   20


<210> 9286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 9286
aatgcctgtt gagacacaaa                                                   20


<210> 9287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9287
ctgacatctt catggcaaag                                                   20


<210> 9288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9288
ttaggtgatt tcatcattct                                                   20


<210> 9289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9289
atctgtacag catgttattg                                                   20


<210> 9290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9290
acaaggggag ataaggaggc                                                   20


<210> 9291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9291
atactaaaca gaagggccta                                                   20


<210> 9292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9292
cactagcctg gtaatttaac                                                   20


<210> 9293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9293
agcctggtaa tttaactaga                                                   20


<210> 9294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9294
taactagaat gaatcaaggt                                                   20


<210> 9295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 9295
aatctcagga acagagaaag                                                   20


<210> 9296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 9296
gccttcagtg aggcattttc                                                   20


<210> 9297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 9297
tgcactccca gcgagccctg                                                   20


<210> 9298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9298
gagacatagg caggacattc                                                   20


<210> 9299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9299
tcttctctcc tgtgctatgg                                                   20


<210> 9300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGAGT

<400> 9300
aactctctct attagcccat                                                   20


<210> 9301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9301
atctgtttct tgctgggacc                                                   20


<210> 9302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 9302
ggaccctgaa tcacatgaca                                                   20


<210> 9303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9303
tcacagctcc caatccaatg                                                   20


<210> 9304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9304
actctgcgat tattctatta                                                   20


<210> 9305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 9305
tttggcaaat tatttcttct                                                   20


<210> 9306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9306
tttcttctgt gagtaaagca                                                   20


<210> 9307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9307
gatctgtcct aagaaacttc                                                   20


<210> 9308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9308
aagaaacttc ctgaatttct                                                   20


<210> 9309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9309
gtgccatttg cccagcctag                                                   20


<210> 9310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 9310
agagccataa gcaggaagag                                                   20


<210> 9311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 9311
ctatcactga ggcagtgatg                                                   20


<210> 9312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9312
agaagcactg ataagaaata                                                   20


<210> 9313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9313
ataagaaata tggggtcaaa                                                   20


<210> 9314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9314
tataatttgc atcactactg                                                   20


<210> 9315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9315
aactcaatct ctctctctct                                                   20


<210> 9316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 9316
atcttctatg tctgtaaaaa                                                   20


<210> 9317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9317
ctatgtctgt aaaaaaggag                                                   20


<210> 9318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 9318
tagaatgggg aggcattgga                                                   20


<210> 9319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 9319
ctaggtggaa gacagcctga                                                   20


<210> 9320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9320
gtgttcatct tctccatgcc                                                   20


<210> 9321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 9321
atcttctcca tgcctggagt                                                   20


<210> 9322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9322
catgcctgga gtcagggttg                                                   20


<210> 9323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 9323
catcatctgt gactccctca                                                   20


<210> 9324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 9324
taagtaaagg cacaaatcta                                                   20


<210> 9325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9325
gtcagaggaa accttgtcac                                                   20


<210> 9326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9326
acatacttgg taagtggttg                                                   20


<210> 9327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9327
acttggtaag tggttgttga                                                   20


<210> 9328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9328
attcattaga tcccatctgt                                                   20


<210> 9329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9329
gatcccatct gtatgaatgt                                                   20


<210> 9330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9330
gacaagagct gtacagtgca                                                   20


<210> 9331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9331
tgtacagtgc aatgagtttc                                                   20


<210> 9332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 9332
aacaatggag agactgaagg                                                   20


<210> 9333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9333
gttgcagcct aatttcctgg                                                   20


<210> 9334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9334
tcataaaccc agagccctca                                                   20


<210> 9335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9335
gccctcagag aattagtgtg                                                   20


<210> 9336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9336
attactaagc tactaaagtg                                                   20


<210> 9337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9337
aagtggagaa tcttgccaat                                                   20


<210> 9338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 9338
taaaagctca gtattataaa                                                   20


<210> 9339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9339
gacacatcca tattaaggaa                                                   20


<210> 9340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ACGAGT

<400> 9340
acagcagtgt ctccttggcc                                                   20


<210> 9341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9341
tccttggcca cgagttattt                                                   20


<210> 9342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9342
caaatggtgg gcaatgtctt                                                   20


<210> 9343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9343
tgtcttctga gtataagcat                                                   20


<210> 9344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9344
gattttccac aaaaaccctc                                                   20


<210> 9345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9345
gcattaggtc tatttaccac                                                   20


<210> 9346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9346
tgtacctggg aaaagaggga                                                   20


<210> 9347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9347
aagagggaga ggatgccttc                                                   20


<210> 9348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9348
tgatacctat ccagccccat                                                   20


<210> 9349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 9349
acctatccag ccccataaga                                                   20


<210> 9350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9350
ataccaagca cctagtattg                                                   20


<210> 9351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9351
gctaatctgt gtggggctga                                                   20


<210> 9352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 9352
atgcagataa atgctgaagt                                                   20


<210> 9353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 9353
gtatatgcac acataaatct                                                   20


<210> 9354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9354
acctatagaa agggcatatt                                                   20


<210> 9355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 9355
gaaagttgca gtgcaaattt                                                   20


<210> 9356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9356
gaaagttatt atggggggaa                                                   20


<210> 9357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 9357
tggggggaaa agaattgcta                                                   20


<210> 9358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9358
gtgctgaagc cattcccagg                                                   20


<210> 9359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 9359
ggctggattg tgtcacagag                                                   20


<210> 9360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9360
tgataacaac aggtgacagc                                                   20


<210> 9361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9361
agaaaaaaaa aaggtgcatg                                                   20


<210> 9362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGGGT

<400> 9362
ttcccacctt tcctacaaac                                                   20


<210> 9363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9363
ttcctccagt gtcctcatct                                                   20


<210> 9364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 9364
attgcccaat cctgaaacct                                                   20


<210> 9365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 9365
agtttaagac accattttgg                                                   20


<210> 9366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9366
acaccatttt ggaggggtgt                                                   20


<210> 9367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 9367
tgtctacggc agctgcaatg                                                   20


<210> 9368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9368
taccatcctg cgctggttgt                                                   20


<210> 9369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGGGT

<400> 9369
gctggttgta aggatcagag                                                   20


<210> 9370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 9370
ggttaaaggt gatccattgt                                                   20


<210> 9371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9371
agtatttgct tggacttagc                                                   20


<210> 9372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9372
atgaatgtgt cccccagaca                                                   20


<210> 9373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 9373
tcccccagac atggggtgcc                                                   20


<210> 9374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 9374
gatctgaaac agagaagctg                                                   20


<210> 9375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 9375
agaagctgaa gggttaggac                                                   20


<210> 9376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9376
ggttaggacc agggtggtgg                                                   20


<210> 9377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TCGGGT

<400> 9377
ccatggcagg aacagacacc                                                   20


<210> 9378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9378
gggtcacccc cactcattca                                                   20


<210> 9379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9379
ctcttttggc tgcctgcttc                                                   20


<210> 9380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 9380
gcttctggga taggtatggg                                                   20


<210> 9381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 9381
ctgtggtaca ggtcatgccc                                                   20


<210> 9382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9382
tcatgcccca gagttcccca                                                   20


<210> 9383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9383
cctcaatagg tcacttgcac                                                   20


<210> 9384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9384
gctagtccag aacagtatcc                                                   20


<210> 9385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 9385
tagattttcc cagaagtcct                                                   20


<210> 9386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9386
tacccatagc acatggaccc                                                   20


<210> 9387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9387
ctccaaccaa gtctgcgtgg                                                   20


<210> 9388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9388
ctgctggtag aggcgttccc                                                   20


<210> 9389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9389
tgagaggaaa gcccaagcaa                                                   20


<210> 9390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CCGGGT

<400> 9390
aaagctggtg tagttaaaat                                                   20


<210> 9391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 9391
ccagggctgc gagacaacca                                                   20


<210> 9392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 9392
cagagtttta tgtcagagat                                                   20


<210> 9393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 9393
cctagtcttc ctcttattag                                                   20


<210> 9394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9394
ggacgctaat actttcacgt                                                   20


<210> 9395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 9395
cgtcagaatt tcatacacag                                                   20


<210> 9396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9396
ccagttcata ccagggaaat                                                   20


<210> 9397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 9397
gagcctgttg gcatcatctg                                                   20


<210> 9398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9398
atgttctttc tttacagata                                                   20


<210> 9399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 9399
tctttacaga taaggaatct                                                   20


<210> 9400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 9400
actgtcaagt agcccaatac                                                   20


<210> 9401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 9401
agattaaaaa tgactgcctg                                                   20


<210> 9402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9402
tgcctggtga gtattgaggt                                                   20


<210> 9403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9403
cttcctctct ctcataatag                                                   20


<210> 9404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9404
ctctctctca taataggagg                                                   20


<210> 9405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9405
gcaatgcctc gtttgaagtc                                                   20


<210> 9406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9406
tttatttacc tgcattcctt                                                   20


<210> 9407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9407
ctgcattcct tgtgaataca                                                   20


<210> 9408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 9408
acatggaatt cttttactcc                                                   20


<210> 9409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 9409
ccatgtgaac aacccatacc                                                   20


<210> 9410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9410
tataaacagt tcactgctct                                                   20


<210> 9411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9411
ttaaccttgg aagctgctga                                                   20


<210> 9412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9412
aagctgctga aaggataaac                                                   20


<210> 9413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 9413
gctttcacgg catgccccgg                                                   20


<210> 9414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9414
aaatgccatt atctagacag                                                   20


<210> 9415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 9415
ccgtcagcct ctcaggcact                                                   20


<210> 9416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 9416
ccaagctctc agccatggag                                                   20


<210> 9417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 9417
caaagcagca ggcagagctg                                                   20


<210> 9418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9418
tcacattctg ttctgccacc                                                   20


<210> 9419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 9419
agtaaagaac ttgttttcca                                                   20


<210> 9420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9420
agggtagcat ctttatgtct                                                   20


<210> 9421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9421
gcaaactagc agcttatagg                                                   20


<210> 9422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9422
aacaatatgt agacattttt                                                   20


<210> 9423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9423
cactccactc atttgttgtt                                                   20


<210> 9424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9424
gttatgaatc tggcctctgt                                                   20


<210> 9425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 9425
gtgttttttc ctctacttgt                                                   20


<210> 9426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9426
ttgtgagggt aatgtggcta                                                   20


<210> 9427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9427
agggtaatgt ggctatagaa                                                   20


<210> 9428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9428
aataagtatt ggttccttcc                                                   20


<210> 9429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 9429
tgacttttca gctctttcca                                                   20


<210> 9430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9430
gaagtctatt tctctgtctc                                                   20


<210> 9431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9431
gactgcaact tgctttagtc                                                   20


<210> 9432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9432
tgctttagtc aagaatgtat                                                   20


<210> 9433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 9433
aggcccaggc taacctgttt                                                   20


<210> 9434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9434
aatatgctgt ctgcatatgc                                                   20


<210> 9435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9435
cagtccaaaa tgctgatgca                                                   20


<210> 9436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9436
aaatgctgat gcacagaatc                                                   20


<210> 9437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9437
tgttttaatt cacaaaattt                                                   20


<210> 9438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9438
acattccctc cccatgagct                                                   20


<210> 9439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9439
tgccaaggac aagatggaga                                                   20


<210> 9440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9440
tcataagttg ggaactcacc                                                   20


<210> 9441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 9441
agatccattg ccacacagta                                                   20


<210> 9442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9442
tccaacccaa gccttgtgtg                                                   20


<210> 9443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9443
tcaatctccc ccagcagagg                                                   20


<210> 9444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 9444
atggctcatt tccttgcaag                                                   20


<210> 9445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9445
ggatgctgag caacaggaaa                                                   20


<210> 9446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 9446
gaaccatttt ggcaggaaag                                                   20


<210> 9447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 9447
ccctgtccct atatgatacc                                                   20


<210> 9448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9448
ccactcacgt tttctgtgag                                                   20


<210> 9449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9449
tatttttgag gttgcccttg                                                   20


<210> 9450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9450
acacttaggc agaagatggt                                                   20


<210> 9451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9451
cacatcagcc agtttcttca                                                   20


<210> 9452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9452
tcagccagtt tcttcactga                                                   20


<210> 9453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 9453
gatgacagtg gtatgaccac                                                   20


<210> 9454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 9454
cctccttcat ctctacatac                                                   20


<210> 9455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9455
tttactctga gaggcaggca                                                   20


<210> 9456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9456
ttcaatttaa ataatttatg                                                   20


<210> 9457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 9457
acacatgaac ctcactgtgt                                                   20


<210> 9458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 9458
agagagagat gcaagagaga                                                   20


<210> 9459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 9459
agacacagag aaacagagag                                                   20


<210> 9460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9460
aagcacagct ggcagcaaag                                                   20


<210> 9461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 9461
atacacctgc ttgtttaagg                                                   20


<210> 9462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9462
ctctgaccag ggaagcaatc                                                   20


<210> 9463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9463
gtcagtccct ggactgggag                                                   20


<210> 9464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TCGAGT

<400> 9464
atggctaagg cagcagcatg                                                   20


<210> 9465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9465
ttaactgaag ttccagaggt                                                   20


<210> 9466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9466
tgaagttcca gaggtgggaa                                                   20


<210> 9467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 9467
gttccagagg tgggaatggg                                                   20


<210> 9468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9468
agaggtggga atggggtggg                                                   20


<210> 9469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9469
aaaaccttgg cagagccctg                                                   20


<210> 9470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9470
ccttggcaga gccctgagga                                                   20


<210> 9471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 9471
cagagccctg aggaatgagt                                                   20


<210> 9472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 9472
ccctgaggaa tgagtgtgag                                                   20


<210> 9473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9473
agttgagtaa agagaggagg                                                   20


<210> 9474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9474
ctgggaggtg agcaatggtg                                                   20


<210> 9475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 9475
gagtatttgc agaaccgtag                                                   20


<210> 9476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 9476
caggtcttgc aaataagact                                                   20


<210> 9477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9477
gactcagggt cttcccagtt                                                   20


<210> 9478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9478
cttcaagagg tgtgtccagt                                                   20


<210> 9479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9479
gtgtccagtg ggaattggca                                                   20


<210> 9480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9480
ggtagaaaag acttccactc                                                   20


<210> 9481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 9481
gaaaagactt ccactctaga                                                   20


<210> 9482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ACGAAT

<400> 9482
ttctgtttac agataagaga                                                   20


<210> 9483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9483
cagataagag aacgaattct                                                   20


<210> 9484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9484
catcaacctc atgggggctg                                                   20


<210> 9485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9485
ttgatggact acttttgttt                                                   20


<210> 9486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9486
tttctgaatt ctcagtaatc                                                   20


<210> 9487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9487
ttgcctaatt cttttttcct                                                   20


<210> 9488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 9488
ttcctctggg tgtctaaaga                                                   20


<210> 9489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 9489
tataaataaa aattcaactg                                                   20


<210> 9490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9490
attcaactga ggggtcttgc                                                   20


<210> 9491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 9491
tgtgggaaga gcactggcct                                                   20


<210> 9492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 9492
ctcttactag tgaagaggcc                                                   20


<210> 9493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 9493
gtctttgccc tggaacctta                                                   20


<210> 9494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 9494
ttcttgtgaa aattagagaa                                                   20


<210> 9495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9495
tgaaaaccaa catatgctct                                                   20


<210> 9496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9496
tctgtgaata aatgctcacc                                                   20


<210> 9497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9497
tttttaatgc tctaagaact                                                   20


<210> 9498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 9498
tagtcagcat ctctgcaagc                                                   20


<210> 9499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 9499
tctctgcaag caagggtcct                                                   20


<210> 9500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9500
gggatgcatg cagcataaat                                                   20


<210> 9501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9501
cagcataaat aaggataacc                                                   20


<210> 9502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9502
tggggtatca ttagcctaga                                                   20


<210> 9503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9503
tcattagcct agaaaggatg                                                   20


<210> 9504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9504
aaggatgcag aatggacact                                                   20


<210> 9505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 9505
ttcattattg caacatcttt                                                   20


<210> 9506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ACGGAT

<400> 9506
ctaggcaaca ctgcatgtgg                                                   20


<210> 9507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 9507
gtggacggat cttcaaacac                                                   20


<210> 9508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 9508
gaaggagacc gccatgtcag                                                   20


<210> 9509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 9509
ctgagatgaa gaaccttctt                                                   20


<210> 9510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9510
accttcttca gagtgtgagc                                                   20


<210> 9511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9511
aacaggtggt ttttggttac                                                   20


<210> 9512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 9512
gttttgggaa acaggtggtg                                                   20


<210> 9513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9513
tgatgcttga ctttctattc                                                   20


<210> 9514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9514
tattcctgag ttacttcatt                                                   20


<210> 9515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9515
tatttcattc ctttttacaa                                                   20


<210> 9516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9516
taataatggc ttattttcct                                                   20


<210> 9517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9517
tctgggtaga tacccagtag                                                   20


<210> 9518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9518
gttctacttt tagttcttta                                                   20


<210> 9519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 9519
ttggttatgg ccattcttgc                                                   20


<210> 9520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9520
ccatttatat atcttctttt                                                   20


<210> 9521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9521
ttcttgtcct ttgcccactt                                                   20


<210> 9522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9522
gtcctttgcc cacttttgga                                                   20


<210> 9523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9523
atttgtgttt cttatagatg                                                   20


<210> 9524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 9524
aaagattttt ctctcatcct                                                   20


<210> 9525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9525
cctatgggtt gtctgtttac                                                   20


<210> 9526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9526
tctatttatt tttgtttttg                                                   20


<210> 9527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 9527
ttgtttttgt tggatttgct                                                   20


<210> 9528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9528
ttgcctaagc caatgtctag                                                   20


<210> 9529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9529
gtttttccaa tgttatcttc                                                   20


<210> 9530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9530
atttaagcct tttatccatc                                                   20


<210> 9531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9531
aattatccca gcaccatttg                                                   20


<210> 9532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 9532
tcccagcacc atttgttgaa                                                   20


<210> 9533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9533
gtaagtattt ggctttattt                                                   20


<210> 9534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 9534
cttagtcttg ctttggctat                                                   20


<210> 9535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9535
ggattccttt ttggttccct                                                   20


<210> 9536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 9536
ttttggttcc ctatgaattt                                                   20


<210> 9537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9537
ttgttatttc tatttctgtg                                                   20


<210> 9538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9538
gtacttcaat ggaaattgta                                                   20


<210> 9539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9539
attttatcca tccatgagca                                                   20


<210> 9540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 9540
ttttttgcag ctgttgtaaa                                                   20


<210> 9541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 9541
tgcagctgtt gtaaaaggga                                                   20


<210> 9542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9542
ttttgtatcc tgaaacttta                                                   20


<210> 9543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9543
ttattagatc taggagcttt                                                   20


<210> 9544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9544
tagatctagg agctttttgg                                                   20


<210> 9545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 9545
gagctttttg gatgagtctt                                                   20


<210> 9546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9546
ttgacttccc ctttactgat                                                   20


<210> 9547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9547
ctaggacttc cagtactatg                                                   20


<210> 9548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9548
gtcttgtttc agttctcagg                                                   20


<210> 9549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 9549
tgtttggtat aatgttggct                                                   20


<210> 9550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9550
atagatggct tttattacct                                                   20


<210> 9551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 9551
ccttctatgc caatttggtt                                                   20


<210> 9552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9552
gttgagggtt ttaatcataa                                                   20


<210> 9553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9553
gttttaatca taatgggatg                                                   20


<210> 9554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9554
tgatcatggt gtgttatctt                                                   20


<210> 9555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9555
tgttatcttt tggatatgtg                                                   20


<210> 9556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9556
caattagcta gcattttgtt                                                   20


<210> 9557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 9557
tttttgcatc tatgttcatc                                                   20


<210> 9558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 9558
tccttttctg gttttggtat                                                   20


<210> 9559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9559
ggcttcataa aatgatttag                                                   20


<210> 9560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9560
ttccctcttt ctgcatcttt                                                   20


<210> 9561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9561
aaattggtac caattcttct                                                   20


<210> 9562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9562
attcttcttt gaatgtctga                                                   20


<210> 9563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9563
atgtctgata gaattcagct                                                   20


<210> 9564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9564
ctttttttcc ttggcaattt                                                   20


<210> 9565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 9565
ctacttgtta ttggtctgtt                                                   20


<210> 9566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9566
taagacagtt gtatatttcc                                                   20


<210> 9567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9567
taaaggtgtt catagtagcc                                                   20


<210> 9568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9568
ttatttctaa ttgagcttat                                                   20


<210> 9569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9569
tgtattatta ttatttttat                                                   20


<210> 9570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 9570
ttccttttct tctgcttggt                                                   20


<210> 9571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 9571
tcatgtattt gtatagtttt                                                   20


<210> 9572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9572
atagttttga gggtttcttt                                                   20


<210> 9573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9573
tttattcgac tgtgctctga                                                   20


<210> 9574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9574
ctatcacgtg gtctatctta                                                   20


<210> 9575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9575
atattccatg tgctgatgaa                                                   20


<210> 9576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9576
tatattctgc agttgtttgg                                                   20


<210> 9577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9577
gacctgtcta gtgctgtcag                                                   20


<210> 9578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9578
gtgttaggtg catatgtatt                                                   20


<210> 9579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9579
aggtctgttt tctctgatat                                                   20


<210> 9580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9580
gcttttggtt tccatttgca                                                   20


<210> 9581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 9581
tgtggctcct tatgtgttag                                                   20


<210> 9582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 9582
agacagtaga tacttggttg                                                   20


<210> 9583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 9583
tgcccttctg tatattttaa                                                   20


<210> 9584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9584
taaggtttta tttcaagatt                                                   20


<210> 9585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9585
attctttgag cttcttgtat                                                   20


<210> 9586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 9586
ttctttttgt gtgtcttagt                                                   20


<210> 9587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 9587
tgcattttgt atttctctaa                                                   20


<210> 9588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9588
tctttatatc tatttctctg                                                   20


<210> 9589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9589
tatctttctc tggtgtctcc                                                   20


<210> 9590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9590
atcacttaat aatcagcctt                                                   20


<210> 9591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 9591
cttttttttt tttttttgag                                                   20


<210> 9592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9592
ttcactcttg ttgcccaggc                                                   20


<210> 9593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9593
aattctcctg cctcagtctc                                                   20


<210> 9594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9594
gcctcagtct cctgagtagc                                                   20


<210> 9595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGGGT

<400> 9595
tttgtatttt ttagtagaga                                                   20


<210> 9596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9596
gtgagctact gtgcccagcc                                                   20


<210> 9597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9597
ttcagagatt tcttcttagt                                                   20


<210> 9598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 9598
ggagctagtt tgatcttttg                                                   20


<210> 9599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9599
accctctttt gtcatattac                                                   20


<210> 9600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 9600
cttttctggt tccttctcat                                                   20


<210> 9601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9601
ttcagagaaa agatctggaa                                                   20


<210> 9602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 9602
tgtgcagatt cttttgtttc                                                   20


<210> 9603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 9603
ggtgctctcc ccaatcccct                                                   20


<210> 9604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9604
acagaggggc taccaggctc                                                   20


<210> 9605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9605
tagtactggg aaatgcctgc                                                   20


<210> 9606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 9606
gatcttgaag tctcccagcc                                                   20


<210> 9607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9607
tgttctggtg aaggtggcag                                                   20


<210> 9608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 9608
aaggtggcag aggaatgaag                                                   20


<210> 9609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9609
aggaatgaag tagagtctgt                                                   20


<210> 9610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9610
gatttagtgt gctggctttc                                                   20


<210> 9611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 9611
actcaggacg tctggttagc                                                   20


<210> 9612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9612
ggttgttgtt ttctttttcc                                                   20


<210> 9613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9613
gggatcaaag ttattctgtc                                                   20


<210> 9614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 9614
cactagtgca ttagtagaag                                                   20


<210> 9615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 9615
taagctcacc ctaagttggc                                                   20


<210> 9616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9616
agcagggcca taaagcttcc                                                   20


<210> 9617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9617
cataaagctt ccgagagttt                                                   20


<210> 9618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 9618
aaataccatc aggtgggggc                                                   20


<210> 9619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 9619
tcaggtgggg gcaggggtag                                                   20


<210> 9620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 9620
agtctagact cagacccttc                                                   20


<210> 9621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 9621
gactcagacc cttcttgggt                                                   20


<210> 9622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 9622
ggattgctgt ggccactgtg                                                   20


<210> 9623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 9623
ctgtggccac tgtggtggat                                                   20


<210> 9624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9624
ggggttggtt ctcaggccag                                                   20


<210> 9625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9625
cagtggggtt gtgttccaga                                                   20


<210> 9626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 9626
tggctgcctc tgctgtgcca                                                   20


<210> 9627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 9627
tagagttctc cagggaagtg                                                   20


<210> 9628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9628
ttgcagttcc catttgcccc                                                   20


<210> 9629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 9629
ttccactggc tgccttcccc                                                   20


<210> 9630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 9630
ggtgcctgtg agacatagtc                                                   20


<210> 9631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 9631
cctgtgagac atagtcaggg                                                   20


<210> 9632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 9632
ctggtctcaa gctggagact                                                   20


<210> 9633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 9633
aatttattta cattccaggt                                                   20


<210> 9634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9634
gtaaattctt ctcctgtgat                                                   20


<210> 9635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9635
ggattttcag attacccagt                                                   20


<210> 9636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9636
acagtttttc acctgtcttg                                                   20


<210> 9637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9637
gcagtgtgcc acttatttaa                                                   20


<210> 9638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9638
ccacttattt aaaaggatct                                                   20


<210> 9639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 9639
ttggagcaaa cgttcatggt                                                   20


<210> 9640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 9640
gcatagagat atactcacgc                                                   20


<210> 9641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9641
gctaaaatcc agccagttcc                                                   20


<210> 9642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 9642
gtgaagacat atctgggaag                                                   20


<210> 9643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 9643
tctgggaagg agggtagaaa                                                   20


<210> 9644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9644
aaggagtgtc aactgtgcca                                                   20


<210> 9645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 9645
tgtgccatgg agtgtactca                                                   20


<210> 9646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 9646
ggttccttct tccaggaggg                                                   20


<210> 9647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9647
gctccaagaa aaaacatgca                                                   20


<210> 9648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9648
agaagggcca cacaaataga                                                   20


<210> 9649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 9649
cacaaataga tggagtgggg                                                   20


<210> 9650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9650
gccagcagct tctgctgttc                                                   20


<210> 9651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GCGGGT

<400> 9651
gggttaggca gagggcagta                                                   20


<210> 9652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9652
ggcagtagcg ggtgaagagc                                                   20


<210> 9653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9653
aactcccagt ttttagaaac                                                   20


<210> 9654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9654
agaaactgga gtgcagactg                                                   20


<210> 9655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9655
gctgaaaact ggctgaagca                                                   20


<210> 9656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 9656
tctgaaagca aggtttgggg                                                   20


<210> 9657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9657
agggtgataa gtagggctga                                                   20


<210> 9658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 9658
aaactgtttc tgctccagaa                                                   20


<210> 9659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9659
gtttctgctc cagaaatgga                                                   20


<210> 9660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9660
gattggatgc tcattttctt                                                   20


<210> 9661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9661
acagccagcc aaggagcatc                                                   20


<210> 9662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9662
caaggagcat caggaatttg                                                   20


<210> 9663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9663
gacaataaag agggcagaag                                                   20


<210> 9664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9664
tactccggag gctgaggcgg                                                   20


<210> 9665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9665
tcgcgtcact gcactccagt                                                   20


<210> 9666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9666
aacctgtact aatattttta                                                   20


<210> 9667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9667
cacgtataga acaagagcag                                                   20


<210> 9668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9668
aagtaccttc aaagacaaaa                                                   20


<210> 9669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 9669
agtggaacaa aaaagcagaa                                                   20


<210> 9670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9670
gataaaaagt ttgaaaatta                                                   20


<210> 9671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9671
agccaaactg tcaaagaagg                                                   20


<210> 9672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9672
tacttgggag gttgaggcag                                                   20


<210> 9673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 9673
caggaggatc acttgaaccc                                                   20


<210> 9674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9674
cttaaaaaaa aatgttacta                                                   20


<210> 9675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9675
cgatccaggg aagaggcaaa                                                   20


<210> 9676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9676
aggcaaaagg aatccaaaaa                                                   20


<210> 9677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9677
ggcctagaaa acatctaggt                                                   20


<210> 9678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9678
caacaattaa acatctggag                                                   20


<210> 9679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 9679
gaagagtttg ggaacaaatt                                                   20


<210> 9680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 9680
attatatatg tagtcataca                                                   20


<210> 9681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 9681
tataactgta acaggaagat                                                   20


<210> 9682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9682
gaagatgagg gtgagaggaa                                                   20


<210> 9683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 9683
gggtgagagg aaatgagttt                                                   20


<210> 9684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9684
aaaaattaaa aattagtatt                                                   20


<210> 9685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9685
gaaattgctg ttttttttgt                                                   20


<210> 9686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9686
agtaaaagtc aagttaaaaa                                                   20


<210> 9687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9687
aatcgtgttt gaaatcattt                                                   20


<210> 9688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9688
taaattagaa aatcttaact                                                   20


<210> 9689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 9689
taggttgttg ggaagctttg                                                   20


<210> 9690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9690
acagacccag aaattatgga                                                   20


<210> 9691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9691
cccagctcaa cagcagctaa                                                   20


<210> 9692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 9692
ctgcaaggta tttcttgatg                                                   20


<210> 9693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9693
tttcctaagt gctttttctg                                                   20


<210> 9694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 9694
ctggtgaatg aagaaaatca                                                   20


<210> 9695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9695
agattcataa tattcaaatt                                                   20


<210> 9696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 9696
tcataatatt caaattctga                                                   20


<210> 9697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9697
tgtgtacctc aacagcaaat                                                   20


<210> 9698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9698
cagaccccca gctgcgttcc                                                   20


<210> 9699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9699
aataaggtat gcactagcat                                                   20


<210> 9700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9700
ctgggagcag catcttctat                                                   20


<210> 9701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9701
ttccttgctg accatgtggc                                                   20


<210> 9702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9702
ccattctact ttctgtctcc                                                   20


<210> 9703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9703
ttctaggtac ctactaaagg                                                   20


<210> 9704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 9704
caacatttgt tcttttgcgt                                                   20


<210> 9705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9705
gtcaatgttg tggcatgtat                                                   20


<210> 9706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9706
aatctcattc atttttaaaa                                                   20


<210> 9707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9707
gatggacata tttggctatt                                                   20


<210> 9708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9708
ataaatagaa caaaaagtca                                                   20


<210> 9709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9709
taaatgccag tcacattata                                                   20


<210> 9710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9710
gaatgcaata cttctaatta                                                   20


<210> 9711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 9711
tggttttgta tcttaccagc                                                   20


<210> 9712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9712
attgtgctta tttttgatat                                                   20


<210> 9713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9713
tgcttatttt tgatatgagg                                                   20


<210> 9714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9714
atattcaatt ggtttaaaag                                                   20


<210> 9715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 9715
aaacgttagc agataataaa                                                   20


<210> 9716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9716
taaattgggt actaggacaa                                                   20


<210> 9717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9717
tgtgacctta tttcacattg                                                   20


<210> 9718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9718
cgaagtgatg actctttttt                                                   20


<210> 9719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9719
ttaactccat gttaaccatt                                                   20


<210> 9720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9720
cataaaaagt tagaaattct                                                   20


<210> 9721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9721
attgtaggag atggagagag                                                   20


<210> 9722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9722
attgctctgc taaacaaagt                                                   20


<210> 9723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9723
taaacaaagt aagaataagt                                                   20


<210> 9724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9724
ttcccaggga caattgagga                                                   20


<210> 9725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9725
ataaaatgaa atacacctaa                                                   20


<210> 9726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9726
atatgctcac tgtcatagct                                                   20


<210> 9727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9727
gaaaaataaa aaagtggtat                                                   20


<210> 9728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9728
tgtctaaata ggaagtccaa                                                   20


<210> 9729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 9729
tttaacttta aggagctcag                                                   20


<210> 9730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9730
taaggagctc agcagggttg                                                   20


<210> 9731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 9731
attaccaaac aaagtttcca                                                   20


<210> 9732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9732
agacaaataa ggaggggcat                                                   20


<210> 9733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 9733
aaatccacgt ggtgttgact                                                   20


<210> 9734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9734
gaaacagatt cagtagacat                                                   20


<210> 9735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9735
tgatgtattg aaaaaaatgt                                                   20


<210> 9736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 9736
gtaactttga ggagaaaaca                                                   20


<210> 9737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9737
aacacaggat aatatcttta                                                   20


<210> 9738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9738
atactatatg gcaataaaaa                                                   20


<210> 9739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9739
tatatggcaa taaaaaatga                                                   20


<210> 9740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9740
ataatttgtc aaaggttttc                                                   20


<210> 9741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 9741
gaatattgtt atgcttagag                                                   20


<210> 9742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 9742
atgcttagag gtgagtgtcc                                                   20


<210> 9743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9743
ctctgaaacc agggcatggg                                                   20


<210> 9744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 9744
gtttcttccc aagcaaaaga                                                   20


<210> 9745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9745
caaaagaggg gattagaaaa                                                   20


<210> 9746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9746
gcaaagctaa tgtttcagca                                                   20


<210> 9747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9747
aggacattta ttatcttcct                                                   20


<210> 9748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9748
ctgattattt ccacgaggcc                                                   20


<210> 9749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 9749
atacctgtca cataaattcc                                                   20


<210> 9750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9750
tttcatagtg tgcatataaa                                                   20


<210> 9751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9751
agttaataca aaatctccta                                                   20


<210> 9752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 9752
aatacaaaat ctcctaaaga                                                   20


<210> 9753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9753
gaatggattt gataattact                                                   20


<210> 9754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9754
tgataattac tgggaatgga                                                   20


<210> 9755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9755
gtgtacaaag atacatgtgt                                                   20


<210> 9756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9756
aatatgtggt ggcaaaatat                                                   20


<210> 9757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9757
ttatgttaat tatgataaat                                                   20


<210> 9758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9758
ttctataaaa cagctgctgc                                                   20


<210> 9759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 9759
gctgctgctg ggattttttt                                                   20


<210> 9760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9760
ggattttttt ggggatgtca                                                   20


<210> 9761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9761
gcactgacat tctaacaatt                                                   20


<210> 9762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9762
gcatattttt acaacagcat                                                   20


<210> 9763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9763
tccatgctgt gacttattcc                                                   20


<210> 9764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9764
ttatagtttg tcttttgtcc                                                   20


<210> 9765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9765
actctatttc attatgatca                                                   20


<210> 9766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 9766
ctttctctga tattaaaatc                                                   20


<210> 9767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9767
tttgcctttg cttatgtctt                                                   20


<210> 9768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 9768
agcctttctg tatcaccgtg                                                   20


<210> 9769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 9769
agtatttttt ttattcaaca                                                   20


<210> 9770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 9770
tttttttatt caacatagag                                                   20


<210> 9771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 9771
ataggcattt ttaaaaatag                                                   20


<210> 9772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9772
tgaaatttgc cgtttgatat                                                   20


<210> 9773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 9773
aattcgagcg attttcttat                                                   20


<210> 9774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 9774
ttttcttatt tgagttcaaa                                                   20


<210> 9775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 9775
atcaacaacg catttggccc                                                   20


<210> 9776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9776
atgagaacct tgaagatgag                                                   20


<210> 9777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 9777
aaggtgaaac agctccataa                                                   20


<210> 9778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9778
attgtgatgt gcgataaaaa                                                   20


<210> 9779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9779
gtctgatcta ctacagcttt                                                   20


<210> 9780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9780
accaacagtt acttcaaaag                                                   20


<210> 9781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9781
acagttactt caaaagttga                                                   20


<210> 9782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGGAT

<400> 9782
tgaaacactt ccataaccag                                                   20


<210> 9783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9783
ggatgcagaa aatgccttcc                                                   20


<210> 9784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9784
aaatgccttc caagagttca                                                   20


<210> 9785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 9785
agttcattga atcccaaagc                                                   20


<210> 9786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9786
agcatggatt tttatgctac                                                   20


<210> 9787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 9787
tgtacaattc ttccagtatt                                                   20


<210> 9788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9788
tacaaatata tagattacta                                                   20


<210> 9789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 9789
tcattctatt ggcattttga                                                   20


<210> 9790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9790
ctattggcat tttgagaggg                                                   20


<210> 9791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 9791
tcatttattt taaaaaatta                                                   20


<210> 9792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9792
ccttaacaaa ataccataga                                                   20


<210> 9793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9793
tggaggttga agcctgagat                                                   20


<210> 9794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 9794
agattgggat gtcagcatag                                                   20


<210> 9795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 9795
atctccaaca tagcaacatg                                                   20


<210> 9796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9796
tggggggttt gtttcaacat                                                   20


<210> 9797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9797
tgctgtaagt tttctcattt                                                   20


<210> 9798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 9798
tactcaaagt ttatggacat                                                   20


<210> 9799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9799
catttgagtg gtttccggtt                                                   20


<210> 9800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 9800
tctgttaaac ataggtacct                                                   20


<210> 9801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9801
ggtacctaag ggtgtaatag                                                   20


<210> 9802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 9802
tacactccca ccagcagtgt                                                   20


<210> 9803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9803
ctttgattta aaaaaaggtt                                                   20


<210> 9804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9804
tttcatatgt ttatggccat                                                   20


<210> 9805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 9805
acatttttct aattgatttg                                                   20


<210> 9806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9806
gatttgtaga gttcattact                                                   20


<210> 9807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9807
gatcaagtcg gcttcatacc                                                   20


<210> 9808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9808
ctcaataaac taggtattga                                                   20


<210> 9809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9809
agcccccagc caatatcata                                                   20


<210> 9810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9810
tttgaaaacc agcacaagac                                                   20


<210> 9811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 9811
tcaggcaaga gaaagaaata                                                   20


<210> 9812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 9812
aagcaacttc agcaaagtct                                                   20


<210> 9813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9813
gacaaaccga gagccaaatc                                                   20


<210> 9814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9814
ccattcacaa ttgcaacaaa                                                   20


<210> 9815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 9815
atctagaaat acaacttaca                                                   20


<210> 9816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 9816
tggaaaaaca ttccatgctc                                                   20


<210> 9817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9817
gctaccactg actttcttca                                                   20


<210> 9818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9818
acaaaagcaa gcaatgggga                                                   20


<210> 9819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9819
caaaagccaa aattgacaaa                                                   20


<210> 9820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 9820
acagcaaaag aaactatcat                                                   20


<210> 9821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9821
caaaagaaac tatcatcaga                                                   20


<210> 9822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9822
cagagtgaat aggtaaccta                                                   20


<210> 9823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9823
tctgacaaag ggctaatatc                                                   20


<210> 9824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9824
actccatcaa aaagtgggca                                                   20


<210> 9825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9825
cagtcaaaac cacaatgaga                                                   20


<210> 9826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9826
agatggagtc tcataccagt                                                   20


<210> 9827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9827
aggaaacaac agatgctgga                                                   20


<210> 9828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9828
tggagaggat gtggagagat                                                   20


<210> 9829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 9829
aatgctttta cactgttggt                                                   20


<210> 9830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9830
agacagtgtg gtgattcctc                                                   20


<210> 9831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9831
ttgacccagc aattccatta                                                   20


<210> 9832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9832
cattactggg tatataccca                                                   20


<210> 9833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9833
aaacgcccat cagtgataga                                                   20


<210> 9834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9834
aatatggcac atatacacca                                                   20


<210> 9835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGGT

<400> 9835
aatactatgc agccataaaa                                                   20


<210> 9836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 9836
ctatgcagcc ataaaaaagg                                                   20


<210> 9837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGAT

<400> 9837
ttcatgttct ttgcagggac                                                   20


<210> 9838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 9838
gagatgaaca atgagagcac                                                   20


<210> 9839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 9839
tcacacacca gggcctgttg                                                   20


<210> 9840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 9840
gaggggttgg gggctagggg                                                   20


<210> 9841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 9841
agaaatacct aatgtagatg                                                   20


<210> 9842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGGGT

<400> 9842
ctaatgtaga tgatgggttg                                                   20


<210> 9843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9843
aagtgaggtg ttgatccacc                                                   20


<210> 9844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9844
ttcttgtgtg tggtgcaaag                                                   20


<210> 9845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9845
ccgccttttc cctgctgttc                                                   20


<210> 9846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9846
tagtaaatct cgacatccag                                                   20


<210> 9847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9847
aaatctcgac atccagtaga                                                   20


<210> 9848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9848
gcctgttgaa atattgattt                                                   20


<210> 9849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAGT

<400> 9849
taaatttatt aatcattttt                                                   20


<210> 9850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9850
gtctttacaa tattgagact                                                   20


<210> 9851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9851
ctgtttatct ctaggttatg                                                   20


<210> 9852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9852
acgcttgata ctttaaaaca                                                   20


<210> 9853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 9853
aaacaatgaa taccctttat                                                   20


<210> 9854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9854
aattattata ctttaagttc                                                   20


<210> 9855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9855
tcattgttca actcccactt                                                   20


<210> 9856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9856
tgttcttgtg ttagtttgct                                                   20


<210> 9857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9857
ccttctattt caacttttct                                                   20


<210> 9858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9858
aaggtatgtt aggttcaagc                                                   20


<210> 9859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGAT

<400> 9859
gaagcatccc tcccagatgt                                                   20


<210> 9860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9860
ccctcccaga tgtgtggata                                                   20


<210> 9861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 9861
ctcccagatt ctgaaactat                                                   20


<210> 9862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9862
cacccactaa cctagggaaa                                                   20


<210> 9863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9863
tagggaaata gaataacttc                                                   20


<210> 9864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9864
taacttaaac agcttcattt                                                   20


<210> 9865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 9865
tttgtgtgtg catctagcag                                                   20


<210> 9866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAGT

<400> 9866
tgtgtgcatc tagcaggtga                                                   20


<210> 9867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGGT

<400> 9867
tgagtgtgtg tgtgttgggg                                                   20


<210> 9868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 9868
attacccaca tgaggcatgg                                                   20


<210> 9869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TCGGGT

<400> 9869
attttctctg gaaggtcagt                                                   20


<210> 9870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9870
caagtctctg tgatgtcatc                                                   20


<210> 9871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9871
catctaggat caccttgatg                                                   20


<210> 9872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9872
ataataacca ctaacattta                                                   20


<210> 9873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9873
tactgagtgc ctaagctagg                                                   20


<210> 9874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 9874
ctaatacaac tgatctacag                                                   20


<210> 9875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9875
gaagaggtac aaactttcat                                                   20


<210> 9876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGGT

<400> 9876
aattagtttc atcagattgt                                                   20


<210> 9877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9877
tccaccgagg aaatggtctt                                                   20


<210> 9878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9878
ctcaggaaga aaaccccaag                                                   20


<210> 9879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9879
aaccccaagt aggattaggc                                                   20


<210> 9880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9880
ttaggctgga gtggagaact                                                   20


<210> 9881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 9881
agtggagaac tctgaatagc                                                   20


<210> 9882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9882
aactctgaat agctagagtg                                                   20


<210> 9883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 9883
tgacagcaga ctatgggcaa                                                   20


<210> 9884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 9884
agggagacat tgaaaggaag                                                   20


<210> 9885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9885
agggaagaaa tgttggtggg                                                   20


<210> 9886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9886
cccacttgga catttttctt                                                   20


<210> 9887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9887
agataaactt gacctacaga                                                   20


<210> 9888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9888
atggggggaa atgttaatcc                                                   20


<210> 9889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9889
acattcatag caaatgtgat                                                   20


<210> 9890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9890
aatattaata atagggccct                                                   20


<210> 9891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9891
attctagtat cttttggggc                                                   20


<210> 9892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9892
tcatcaaatc tcaagatgaa                                                   20


<210> 9893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 9893
tggtcacttg gttcttttta                                                   20


<210> 9894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9894
ttatccagat gtaattcaac                                                   20


<210> 9895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAGT

<400> 9895
ttcaaccaga atccataaag                                                   20


<210> 9896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9896
aagcagagac gacacattga                                                   20


<210> 9897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 9897
actgtagata ctgctctacg                                                   20


<210> 9898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9898
tcttaactag ctacatggtc                                                   20


<210> 9899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGGAT

<400> 9899
agtttcatta tctgtaaaat                                                   20


<210> 9900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAAT

<400> 9900
tgtcattaaa tatccttctg                                                   20


<210> 9901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 9901
tcaagctgtg cagcttcatg                                                   20


<210> 9902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAGT

<400> 9902
agaaatccaa caatctgcct                                                   20


<210> 9903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 9903
tctgcctcag agttagggag                                                   20


<210> 9904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9904
ttccaatcct tccgatgacc                                                   20


<210> 9905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9905
gaccaaggat cttaggtcat                                                   20


<210> 9906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9906
ggtcattagg atctttccat                                                   20


<210> 9907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 9907
tttaaacctg ctagtagttt                                                   20


<210> 9908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9908
agcggaccac acaccgtggt                                                   20


<210> 9909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9909
agcaaacctc ccctcataaa                                                   20


<210> 9910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9910
tgtgtctaga ttagtctgag                                                   20


<210> 9911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9911
tctgtgtctt gggactgctt                                                   20


<210> 9912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9912
taatgacctc attgtacttt                                                   20


<210> 9913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9913
attgtacttt tgggattcaa                                                   20


<210> 9914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9914
gtggaagagg caatcgtgca                                                   20


<210> 9915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9915
gaggcaatcg tgcaaaggat                                                   20


<210> 9916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAAT

<400> 9916
ttctgatcag gttgaaagga                                                   20


<210> 9917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CCGAGT

<400> 9917
ggactgaata gccacagggc                                                   20


<210> 9918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAGT

<400> 9918
tctgggaact acaggtcaat                                                   20


<210> 9919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9919
tgcaggtaca gagaggcaga                                                   20


<210> 9920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGGT

<400> 9920
tgcaccaaga tgagcccact                                                   20


<210> 9921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGAT

<400> 9921
ccaggggagg actctggcaa                                                   20


<210> 9922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9922
ctctcctggt ttctccctct                                                   20


<210> 9923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9923
ttctccctct gaggatttag                                                   20


<210> 9924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 9924
ttctcaaact ttttgatttc                                                   20


<210> 9925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9925
ctcaggaaat tttaaaacac                                                   20


<210> 9926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 9926
gcacacattc cagtagcttt                                                   20


<210> 9927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 9927
aaaacagttt tggggacacc                                                   20


<210> 9928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGGGT

<400> 9928
agttatctgc ttttgaagat                                                   20


<210> 9929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGAAT

<400> 9929
atattttttt tggttgttaa                                                   20


<210> 9930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9930
gccaaggagg actttctggg                                                   20


<210> 9931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ACGGAT

<400> 9931
tacccggtgt gtgctgtaga                                                   20


<210> 9932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CGGAGT

<400> 9932
tctatctcca ccagtgactc                                                   20


<210> 9933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 9933
gacggaagtt gttagtttcg                                                   20


<210> 9934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9934
tagtttcgag ggatccaatg                                                   20


<210> 9935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAGT

<400> 9935
ggaagtattt atactcttat                                                   20


<210> 9936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 9936
caaccctcct ccaggtgcct                                                   20


<210> 9937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9937
tctcctcatt tccaggacca                                                   20


<210> 9938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9938
gtcaacattt ctccacctgt                                                   20


<210> 9939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGAAT

<400> 9939
tggagaactc cagattattg                                                   20


<210> 9940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 9940
acagttcccc tgaactgctg                                                   20


<210> 9941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9941
ggggaacctc agtattgcct                                                   20


<210> 9942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9942
accattcctt tccctctgct                                                   20


<210> 9943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9943
cacttttcag tctttgaagc                                                   20


<210> 9944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGAT

<400> 9944
tcactaaaat gcttccttgc                                                   20


<210> 9945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGGGT

<400> 9945
ttcttttttt ttttttgaga                                                   20


<210> 9946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 9946
ggtatcactg tcacccggac                                                   20


<210> 9947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CCGAAT

<400> 9947
aattctccca cctcagcctc                                                   20


<210> 9948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GTGAAT

<400> 9948
agcttttccc atacatgatt                                                   20


<210> 9949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9949
ggcactctat cttttgtttt                                                   20


<210> 9950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGAT

<400> 9950
attccactgt atttcagact                                                   20


<210> 9951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9951
tttccaagat cacattacta                                                   20


<210> 9952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGAGT

<400> 9952
tctcatttat atgcagatga                                                   20


<210> 9953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CTGGGT

<400> 9953
tttctgtgtc tgtccacaac                                                   20


<210> 9954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9954
ctacttttat aagtttatcc                                                   20


<210> 9955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9955
gacctatatg aagtctatgt                                                   20


<210> 9956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9956
tgcctggaac taactagata                                                   20


<210> 9957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAAT

<400> 9957
acagaataga tagttgttgc                                                   20


<210> 9958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9958
aaaatcacag atccaataat                                                   20


<210> 9959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAGT

<400> 9959
ataaggaacc aaagagatta                                                   20


<210> 9960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9960
accataccta gaggtatttc                                                   20


<210> 9961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9961
cttatagttt ggaaccaaat                                                   20


<210> 9962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGAAT

<400> 9962
cagttgttta gtaacaatgc                                                   20


<210> 9963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAAT

<400> 9963
aagaattctc tcagtgacac                                                   20


<210> 9964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GAGGAT

<400> 9964
tgacactgga atgcaatgtt                                                   20


<210> 9965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9965
gattgagaac aggactaagc                                                   20


<210> 9966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9966
gacaaaattg ttttcaacat                                                   20


<210> 9967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9967
attgttttca acattggggt                                                   20


<210> 9968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9968
agaagtgata gctctggact                                                   20


<210> 9969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9969
tgacattctg agaaaactat                                                   20


<210> 9970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGAAT

<400> 9970
tttatctgag agctatttct                                                   20


<210> 9971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: CAGAAT

<400> 9971
tcttatgggc aaactgggct                                                   20


<210> 9972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AGGGGT

<400> 9972
ggctcagaat tgtttcactg                                                   20


<210> 9973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: AAGGAT

<400> 9973
gaattgtttc actgaggggt                                                   20


<210> 9974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGGT

<400> 9974
tcactgaggg gtaaggatac                                                   20


<210> 9975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGAT

<400> 9975
ttattggttg acggttgtcc                                                   20


<210> 9976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: GGGAAT

<400> 9976
tagtccttgc aaccttaatt                                                   20


<210> 9977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGAGT

<400> 9977
ttaattggga atccctattt                                                   20


<210> 9978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGAAT

<400> 9978
atccctattt tagagtctag                                                   20


<210> 9979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TAGGAT

<400> 9979
catatcaaat gtatgtgtta                                                   20


<210> 9980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TTGGAT

<400> 9980
ctgggcctga tactcacttc                                                   20


<210> 9981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: ATGAGT

<400> 9981
ctggctttca aacagtctgc                                                   20


<210> 9982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGAGT

<400> 9982
tctcactctg ttgtccaggc                                                   20


<210> 9983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNGRRT;
      PAM sequence: TGGGGT

<400> 9983
gctaatcttc atatttttga                                                   20


<210> 9984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGTTT

<400> 9984
tttttaaaaa ttcaaataaa                                                   20


<210> 9985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAAGATT

<400> 9985
tctgggaaaa agagtgtcag                                                   20


<210> 9986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTGGATT

<400> 9986
caaatgtcca acagtgatag                                                   20


<210> 9987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTATGTTT

<400> 9987
ctataaagac acatgcacac                                                   20


<210> 9988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGATT

<400> 9988
ccattactgg gtatataccc                                                   20


<210> 9989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGCTT

<400> 9989
aatgggatct cattaaacta                                                   20


<210> 9990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGATT

<400> 9990
ttatacaaaa attaattcaa                                                   20


<210> 9991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGATT

<400> 9991
gacaaaaaca agaaatgggg                                                   20


<210> 9992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGTTT

<400> 9992
agttcactca tgatttggct                                                   20


<210> 9993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCATGATT

<400> 9993
aattgtgaat gggagttcac                                                   20


<210> 9994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTGGTTT

<400> 9994
cctcttttat ttcactgagc                                                   20


<210> 9995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGTTT

<400> 9995
tgagcatgga gtattcttcc                                                   20


<210> 9996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TATTGATT

<400> 9996
cagtatggcc attttcaaga                                                   20


<210> 9997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTAGCTT

<400> 9997
attctgagaa gaaagtcatt                                                   20


<210> 9998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTAGTTT

<400> 9998
tggttccgta tgaactttaa                                                   20


<210> 9999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAGGATT

<400> 9999
aggttaaaaa aaaaacagga                                                   20


<210> 10000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAGGATT

<400> 10000
aaagtaaggt taaaaaaaaa                                                   20


<210> 10001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGTTT

<400> 10001
gctaaaaagt aaaaaaaagt                                                   20


<210> 10002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTGGTTT

<400> 10002
tataggtata catgtgccat                                                   20


<210> 10003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACATGTTT

<400> 10003
agggtacatg tgcacaatgt                                                   20


<210> 10004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAGGTTT

<400> 10004
tctggagctg aacacaggct                                                   20


<210> 10005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGCTT

<400> 10005
gagccctggt gtgctggagc                                                   20


<210> 10006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTAGATT

<400> 10006
ggtacaatta caaggtagaa                                                   20


<210> 10007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCAGTTT

<400> 10007
cttttgaaaa tttcactaga                                                   20


<210> 10008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCAAGATT

<400> 10008
ttttggaaat gtatccaaat                                                   20


<210> 10009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CGGAGTTT

<400> 10009
tatacacatc ttgcatgaca                                                   20


<210> 10010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTAGTTT

<400> 10010
atttctatta ttgtcatcta                                                   20


<210> 10011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTTGATT

<400> 10011
ggaacatggc tctgccaata                                                   20


<210> 10012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCGGGCTT

<400> 10012
gaaggcaacg gttctcacct                                                   20


<210> 10013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGATT

<400> 10013
atgtgcaggc caaggaatgg                                                   20


<210> 10014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAGGTTT

<400> 10014
attgtgacct tatttgacat                                                   20


<210> 10015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGATT

<400> 10015
gaagttctaa ccaatagtac                                                   20


<210> 10016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGCTT

<400> 10016
taattcaact ttatgttgaa                                                   20


<210> 10017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAGGTTT

<400> 10017
agtggacaga gagtttgggc                                                   20


<210> 10018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGTTT

<400> 10018
ataagacagc taagtggaca                                                   20


<210> 10019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGTGTTT

<400> 10019
gccatctgag atactagccc                                                   20


<210> 10020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGCTT

<400> 10020
gggagcacag atactgactg                                                   20


<210> 10021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCTGATT

<400> 10021
aaatcagcta ttctctgaat                                                   20


<210> 10022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGATGCTT

<400> 10022
agaagtcaaa gaggctctca                                                   20


<210> 10023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TACAGATT

<400> 10023
catctcacat gcctcaagaa                                                   20


<210> 10024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAAGATT

<400> 10024
tctatatatt tgatcatttc                                                   20


<210> 10025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGATT

<400> 10025
cccattccca gccacaatca                                                   20


<210> 10026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGGGATT

<400> 10026
ccctataaca acataggaca                                                   20


<210> 10027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGATT

<400> 10027
tatttaggcc aaaggcatgt                                                   20


<210> 10028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGTTT

<400> 10028
aatggagtaa gaattgtcag                                                   20


<210> 10029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGATT

<400> 10029
aaaataggaa ttaagccccc                                                   20


<210> 10030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTAGTTT

<400> 10030
agtagataaa aggtatggcc                                                   20


<210> 10031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGTTT

<400> 10031
cataatcaga cattaaggag                                                   20


<210> 10032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCAGCTT

<400> 10032
ttctgttgtg tagctaaaga                                                   20


<210> 10033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAATGCTT

<400> 10033
tggtgggaag ggaagaaaat                                                   20


<210> 10034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGAGATT

<400> 10034
ggatcctgat atttttcagt                                                   20


<210> 10035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGTTT

<400> 10035
tttctgggat cctgatattt                                                   20


<210> 10036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAGGATT

<400> 10036
acagagattg gcaatattat                                                   20


<210> 10037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGATT

<400> 10037
gtcctctgtg gagcaccata                                                   20


<210> 10038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCAGATT

<400> 10038
gtccttttat ttttgttgta                                                   20


<210> 10039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGATT

<400> 10039
agaagctaag agcacttcca                                                   20


<210> 10040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGATT

<400> 10040
agatgaagcc accagtatgg                                                   20


<210> 10041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AACTGCTT

<400> 10041
gtactcccag acaaatctga                                                   20


<210> 10042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAGGTTT

<400> 10042
aggctgcatc actcccagat                                                   20


<210> 10043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAAGTTT

<400> 10043
tctgaaggca aatatggagg                                                   20


<210> 10044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTGGATT

<400> 10044
gtcctaggag aatccgggga                                                   20


<210> 10045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGCTT

<400> 10045
atccactgct tggacatcct                                                   20


<210> 10046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGCTT

<400> 10046
tggtccctgg agataagatc                                                   20


<210> 10047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGTTT

<400> 10047
gaagtttgac ccagaggcca                                                   20


<210> 10048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAAGTTT

<400> 10048
catgttctat gagacctggg                                                   20


<210> 10049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGATT

<400> 10049
catggtcaac atgtacattg                                                   20


<210> 10050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGATT

<400> 10050
caacagcatg ctgtgcctct                                                   20


<210> 10051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGCTT

<400> 10051
tctactctat cttcggtatg                                                   20


<210> 10052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCTGATT

<400> 10052
atttcttcct tcttttaaag                                                   20


<210> 10053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAAGTTT

<400> 10053
gctgaacttg gctgcagaag                                                   20


<210> 10054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGCTT

<400> 10054
cagctggtca ttcaaatccc                                                   20


<210> 10055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGCTT

<400> 10055
cagggaacct ggcaaggagc                                                   20


<210> 10056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGATT

<400> 10056
aattcacaga aggtcttcca                                                   20


<210> 10057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGTGATT

<400> 10057
tcttctttcc caccaacaag                                                   20


<210> 10058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGCTT

<400> 10058
atatcttaac taccagttcc                                                   20


<210> 10059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTTGTTT

<400> 10059
attttatatt aaagaaggga                                                   20


<210> 10060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGAGCTT

<400> 10060
tttgatttta tattaaagaa                                                   20


<210> 10061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGATT

<400> 10061
atgaaagatt ccaaaggcta                                                   20


<210> 10062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGATT

<400> 10062
ttttgtttgt cttccaaaat                                                   20


<210> 10063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 10063
ttgttttcat ttttgttttg                                                   20


<210> 10064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 10064
gttagttgtt ttcatttttg                                                   20


<210> 10065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 10065
ggttggttag ttgttttcat                                                   20


<210> 10066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTTGTTT

<400> 10066
tttttgttgg ttggttggtt                                                   20


<210> 10067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGTTT

<400> 10067
cttatctcac ttagcataat                                                   20


<210> 10068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGCTT

<400> 10068
gtcgtttttg tccttctgtg                                                   20


<210> 10069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTCGTTT

<400> 10069
tccttatata aatgcaatca                                                   20


<210> 10070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGATT

<400> 10070
gctcccatga gtttgactat                                                   20


<210> 10071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGTTT

<400> 10071
ccattctatt ctctgctccc                                                   20


<210> 10072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGTTT

<400> 10072
tttattcatg tcacataact                                                   20


<210> 10073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTAGGATT

<400> 10073
actatgctat aagtagagct                                                   20


<210> 10074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAAGATT

<400> 10074
ttattgggtg ctaggaacac                                                   20


<210> 10075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGTTT

<400> 10075
tgtttaatgt acacaacttt                                                   20


<210> 10076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACATGTTT

<400> 10076
atccacatgt aaaaagctat                                                   20


<210> 10077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGTTT

<400> 10077
gttttatttt gatattgctg                                                   20


<210> 10078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGTTT

<400> 10078
ggatttcagt ttgtttttgt                                                   20


<210> 10079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTTGTTT

<400> 10079
gtgtatttcc ggggatttca                                                   20


<210> 10080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGTTT

<400> 10080
ttgcgtgtat ttccggggat                                                   20


<210> 10081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CGGGGATT

<400> 10081
ccttgggttg cgtgtatttc                                                   20


<210> 10082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGATT

<400> 10082
tagctgtaga tttaatttgc                                                   20


<210> 10083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTAGATT

<400> 10083
ttttcatgtc ggggtgtagc                                                   20


<210> 10084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCTGCTT

<400> 10084
tcttgattgg ttatatcctg                                                   20


<210> 10085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGATT

<400> 10085
cacctggcat tataaatgta                                                   20


<210> 10086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCAGCTT

<400> 10086
ataaaggcca aatcatgctc                                                   20


<210> 10087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAAGTTT

<400> 10087
ccctgggctt atgggttagc                                                   20


<210> 10088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGCTT

<400> 10088
caacagccaa gagactgtcc                                                   20


<210> 10089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGTTT

<400> 10089
agagtttcca agggttgaag                                                   20


<210> 10090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGTTT

<400> 10090
aagaatatta tgcagggtca                                                   20


<210> 10091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGATT

<400> 10091
actgggagga gattgttcaa                                                   20


<210> 10092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGATT

<400> 10092
caaagtgagg aaagactggg                                                   20


<210> 10093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGATT

<400> 10093
aaatctgttc tggaaaagga                                                   20


<210> 10094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGTGTTT

<400> 10094
gccttctcca tgctcacacg                                                   20


<210> 10095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCAAGTTT

<400> 10095
tttgcagctt tccaagagta                                                   20


<210> 10096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGCTT

<400> 10096
tgttagaaga accctgtatt                                                   20


<210> 10097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACGTGTTT

<400> 10097
accaaccaac tttttgaaat                                                   20


<210> 10098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGTTT

<400> 10098
acgtggtggg gaagccccac                                                   20


<210> 10099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGTTT

<400> 10099
ctacttcaca aatggctgga                                                   20


<210> 10100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTCGCTT

<400> 10100
ggcgaatgtg tcatgaagat                                                   20


<210> 10101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAAGCTT

<400> 10101
gtctttgaca tcgtgaccag                                                   20


<210> 10102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGGGTTT

<400> 10102
tgttttctca gaacaagttc                                                   20


<210> 10103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGTTT

<400> 10103
aaggccctga tgccactatc                                                   20


<210> 10104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTGGTTT

<400> 10104
atctacagat aacacagatg                                                   20


<210> 10105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTCGCTT

<400> 10105
tggaagaggt aaggatagta                                                   20


<210> 10106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGATT

<400> 10106
agtaagtgga gcttaaaaga                                                   20


<210> 10107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGAGCTT

<400> 10107
gggacactcc atgcagtaag                                                   20


<210> 10108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAAGTTT

<400> 10108
cagagggaac atttccaaga                                                   20


<210> 10109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGCTT

<400> 10109
accctacgcc ctatacctgc                                                   20


<210> 10110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGCTT

<400> 10110
aaagaagaga agatcacagt                                                   20


<210> 10111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAAGTTT

<400> 10111
tgagctccat agaggtcagg                                                   20


<210> 10112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGGGTTT

<400> 10112
ggcaaagctt caaagcaaga                                                   20


<210> 10113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGCTT

<400> 10113
gaagtgacaa aactaggtgg                                                   20


<210> 10114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGTTT

<400> 10114
attactgagg cagagggacc                                                   20


<210> 10115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGAGATT

<400> 10115
gttaggagaa actaggtcat                                                   20


<210> 10116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGCTT

<400> 10116
agatgtaagt ttctgaaata                                                   20


<210> 10117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTAAGTTT

<400> 10117
gatggtagct ggagggagat                                                   20


<210> 10118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGCTT

<400> 10118
tacacaactc tttcaagaaa                                                   20


<210> 10119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGATT

<400> 10119
gctgaggagt gaatgaggga                                                   20


<210> 10120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TACAGTTT

<400> 10120
acagacaaag ttcctactct                                                   20


<210> 10121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAGGCTT

<400> 10121
tccctcatag ccactcatgc                                                   20


<210> 10122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGCTT

<400> 10122
cctcatcaca gcacttcccc                                                   20


<210> 10123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGATT

<400> 10123
catgagcaaa ggccactttg                                                   20


<210> 10124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGGGATT

<400> 10124
cattttcagt gatgaaatgg                                                   20


<210> 10125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGTTT

<400> 10125
cttaacgatg ccgttgcctg                                                   20


<210> 10126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAGGATT

<400> 10126
gtttcttcca taggaaaagt                                                   20


<210> 10127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGTTT

<400> 10127
gatgatgctc aggctctaaa                                                   20


<210> 10128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGCTT

<400> 10128
gcatgggtgc catttcatga                                                   20


<210> 10129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAGGATT

<400> 10129
cataccagca aagcactgac                                                   20


<210> 10130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCAGATT

<400> 10130
ccaggcccag cttgcttttg                                                   20


<210> 10131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTTGCTT

<400> 10131
gacccttctt cccaggccca                                                   20


<210> 10132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCAGCTT

<400> 10132
ctaagaccct tcttcccagg                                                   20


<210> 10133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTGGATT

<400> 10133
catcctttga atggaagaag                                                   20


<210> 10134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGATT

<400> 10134
cctcataacc aattctgttc                                                   20


<210> 10135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGCTT

<400> 10135
caaccccata ggctgccaaa                                                   20


<210> 10136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCAGCTT

<400> 10136
actcaatctc tctttgacat                                                   20


<210> 10137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGTTT

<400> 10137
acaacccttg gcaaaaacat                                                   20


<210> 10138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTAAGATT

<400> 10138
ggcctttact tgtggctgga                                                   20


<210> 10139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTGGATT

<400> 10139
tcacccatac aatcaagata                                                   20


<210> 10140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CACAGCTT

<400> 10140
ggttcagacc tctgtagggg                                                   20


<210> 10141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGATT

<400> 10141
ggtcatgaat ttattactag                                                   20


<210> 10142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAGGATT

<400> 10142
agattttttt aaatcaaggt                                                   20


<210> 10143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTAGATT

<400> 10143
tgcattctgt tagccaagct                                                   20


<210> 10144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAGGTTT

<400> 10144
acttttttgg gaatggatga                                                   20


<210> 10145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CATGGCTT

<400> 10145
ttcataaaga tctcaagaga                                                   20


<210> 10146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGTTT

<400> 10146
ggcaaaaatt agggccagac                                                   20


<210> 10147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGATT

<400> 10147
aaagttatcc cactcgagtt                                                   20


<210> 10148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCGAGTTT

<400> 10148
ggaaccaaaa gttatcccac                                                   20


<210> 10149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGGGATT

<400> 10149
cagtaagggt agttagaacc                                                   20


<210> 10150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAGGATT

<400> 10150
aacagtttta gagttcaagt                                                   20


<210> 10151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AACAGTTT

<400> 10151
gggaagcact gagtttctcc                                                   20


<210> 10152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGTTT

<400> 10152
tgaatctgtt gggggaagca                                                   20


<210> 10153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGTTT

<400> 10153
caggcagggg cctgagggag                                                   20


<210> 10154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAGGTTT

<400> 10154
cacggcccct ggtgagcccc                                                   20


<210> 10155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGCTT

<400> 10155
tggtatccgt agggggttcc                                                   20


<210> 10156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGATT

<400> 10156
gatcctttct ctcctgcctg                                                   20


<210> 10157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGTTT

<400> 10157
agacactcct tgatgctggg                                                   20


<210> 10158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGCTT

<400> 10158
tggcaagaca ctccttgatg                                                   20


<210> 10159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGCTT

<400> 10159
ccctggagaa cagaaactgg                                                   20


<210> 10160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTGGCTT

<400> 10160
tggatccctg gagaacagaa                                                   20


<210> 10161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCTGTTT

<400> 10161
acatgtacct tctccttgag                                                   20


<210> 10162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGATT

<400> 10162
tgaacaggct agatccaagg                                                   20


<210> 10163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGCTT

<400> 10163
gcttctgtcc ctcccagagt                                                   20


<210> 10164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGGGCTT

<400> 10164
ctcctctcca gaaaagattt                                                   20


<210> 10165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGATT

<400> 10165
cctcatctcc tcctctccag                                                   20


<210> 10166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGTTT

<400> 10166
gaggaaaaca tcttcgttgg                                                   20


<210> 10167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGTTT

<400> 10167
tatgtcagga agctaaaggt                                                   20


<210> 10168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTGGCTT

<400> 10168
ataaacatgt tattaaaata                                                   20


<210> 10169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCAGTTT

<400> 10169
tcaaattcca cagatctcag                                                   20


<210> 10170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AACAGATT

<400> 10170
tgagaaaact gaggtcaaga                                                   20


<210> 10171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGAGATT

<400> 10171
atttagtacc ctggggaggt                                                   20


<210> 10172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAGGTTT

<400> 10172
agtgctattt agtaccctgg                                                   20


<210> 10173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGTTT

<400> 10173
gcataagaca actttggtgg                                                   20


<210> 10174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGATT

<400> 10174
ggggctaata atacctactc                                                   20


<210> 10175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGTTT

<400> 10175
tattttaaac ccctctgagt                                                   20


<210> 10176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGTTT

<400> 10176
gtcacagagt acatgcaaac                                                   20


<210> 10177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGATT

<400> 10177
ctgaggtaga taggcgctgt                                                   20


<210> 10178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCATGTTT

<400> 10178
atcgaatccc agataacctc                                                   20


<210> 10179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGATT

<400> 10179
tgtgcctcca agggtgccga                                                   20


<210> 10180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAGGCTT

<400> 10180
accctccttg ggatggggag                                                   20


<210> 10181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAGGATT

<400> 10181
tgccccacta acatcctcac                                                   20


<210> 10182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGATT

<400> 10182
tatcagtgct aacccttgcc                                                   20


<210> 10183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGTTT

<400> 10183
ataagtggtg ctcaggagtt                                                   20


<210> 10184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGTTT

<400> 10184
aaaaaagata agtggtgctc                                                   20


<210> 10185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAGGCTT

<400> 10185
ttgtcatctt catcattttt                                                   20


<210> 10186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGCTT

<400> 10186
acccaggtcc atgtcttagg                                                   20


<210> 10187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAGGCTT

<400> 10187
cctgcaccca ggtccatgtc                                                   20


<210> 10188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCTGCTT

<400> 10188
attcttcccc actccctcat                                                   20


<210> 10189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCCGCTT

<400> 10189
ttcacaggct cttctcccat                                                   20


<210> 10190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCTGCTT

<400> 10190
ttcagttgcc cacaatgatg                                                   20


<210> 10191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGCGCTT

<400> 10191
ctcagaggac cccagtagga                                                   20


<210> 10192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTAGGATT

<400> 10192
cagttactca gaggacccca                                                   20


<210> 10193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGTTT

<400> 10193
gggagtctga ggataaatac                                                   20


<210> 10194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAAGTTT

<400> 10194
cctaggggca acccttacca                                                   20


<210> 10195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGGGATT

<400> 10195
gcaacttctc ccccaagtac                                                   20


<210> 10196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGCTT

<400> 10196
gtataaagac tccagggctt                                                   20


<210> 10197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGGGCTT

<400> 10197
gattctctgt ataaagactc                                                   20


<210> 10198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGATT

<400> 10198
atttcacctg caggctgcac                                                   20


<210> 10199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGATT

<400> 10199
cacctcttcc cttagcccac                                                   20


<210> 10200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGCTT

<400> 10200
ctgagattgc gtcactgcac                                                   20


<210> 10201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGATT

<400> 10201
gaggcagaag ttgcagtgag                                                   20


<210> 10202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCGGCTT

<400> 10202
gaaagaaatt agcagggcat                                                   20


<210> 10203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCAGATT

<400> 10203
cactttggga ggccgaggtg                                                   20


<210> 10204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CGAGGTTT

<400> 10204
tctacactcc ccaggcttct                                                   20


<210> 10205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAGGCTT

<400> 10205
ccccctttca tctacactcc                                                   20


<210> 10206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CGAGGCTT

<400> 10206
ctgttgagtg tttcagccac                                                   20


<210> 10207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGTGTTT

<400> 10207
tgtccagctg gctctctgtt                                                   20


<210> 10208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTTGATT

<400> 10208
atggacatta tgtatgcagc                                                   20


<210> 10209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CATGGCTT

<400> 10209
ctcctctctc actgggccac                                                   20


<210> 10210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGATT

<400> 10210
ggattacttt aaatcatcat                                                   20


<210> 10211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGGGATT

<400> 10211
ctattcttaa acagccacat                                                   20


<210> 10212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCAGTTT

<400> 10212
tgaacatgct ggaaggcaca                                                   20


<210> 10213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGCTT

<400> 10213
cctgggagat acagtcagaa                                                   20


<210> 10214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGGGATT

<400> 10214
cataaaggga tgggcctgcc                                                   20


<210> 10215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGCTT

<400> 10215
accatgagat caaccatatc                                                   20


<210> 10216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCAGCTT

<400> 10216
gcaagattca aaactccact                                                   20


<210> 10217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCAAGATT

<400> 10217
tgtgaataac aagtctgact                                                   20


<210> 10218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTCGATT

<400> 10218
agagttttcc cttgtacctt                                                   20


<210> 10219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGTTT

<400> 10219
gtgcatcaac tataccgatg                                                   20


<210> 10220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGTTT

<400> 10220
gggtgtgaac ctcttcgcag                                                   20


<210> 10221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGCTT

<400> 10221
tgcactaatt aacccacttc                                                   20


<210> 10222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTATGCTT

<400> 10222
cacacttcta aatgagtgca                                                   20


<210> 10223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGTGTTT

<400> 10223
aaattgtatt taaattgtgt                                                   20


<210> 10224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGTGTTT

<400> 10224
tactttaaat tgtatttaaa                                                   20


<210> 10225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAGGTTT

<400> 10225
gctattttgt gaatatggat                                                   20


<210> 10226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TATGGATT

<400> 10226
caaataagct attttgtgaa                                                   20


<210> 10227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGCTT

<400> 10227
tttgtatcta atagattctc                                                   20


<210> 10228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATAGATT

<400> 10228
atttattcta ttttgtatct                                                   20


<210> 10229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATAGTTT

<400> 10229
cactaggacc cgaagattga                                                   20


<210> 10230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CGAAGATT

<400> 10230
cctttacaaa cactaggacc                                                   20


<210> 10231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGGGCTT

<400> 10231
tcatagcttc aaaaacaaaa                                                   20


<210> 10232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CATAGCTT

<400> 10232
cattggctgg aagtagtcat                                                   20


<210> 10233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGCTT

<400> 10233
ctccccagca gaaagtaagg                                                   20


<210> 10234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAGGTTT

<400> 10234
aatggctccc cagcagaaag                                                   20


<210> 10235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGATT

<400> 10235
cagagccttg tcttagagat                                                   20


<210> 10236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGAGATT

<400> 10236
tcacagccag agccttgtct                                                   20


<210> 10237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAATGCTT

<400> 10237
acctcagctg ccacccactg                                                   20


<210> 10238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCAGGTTT

<400> 10238
acaaaaaact tctctggtct                                                   20


<210> 10239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCGAGATT

<400> 10239
cgaggtgtgg tggtagtgag                                                   20


<210> 10240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTCGATT

<400> 10240
tgcggccact gcgggctctt                                                   20


<210> 10241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CGAAGATT

<400> 10241
ctcactgata agtctcacag                                                   20


<210> 10242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGTTT

<400> 10242
gcctttctgg aaacctagag                                                   20


<210> 10243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGCTT

<400> 10243
aataaggtgg gagctaggat                                                   20


<210> 10244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GATTGTTT

<400> 10244
gactgagttt ttcttgccca                                                   20


<210> 10245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCAGATT

<400> 10245
tagagactga gtttttcttg                                                   20


<210> 10246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGTTT

<400> 10246
gaggttggtg atgttagaga                                                   20


<210> 10247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGCTT

<400> 10247
aagagttgat ttaatacact                                                   20


<210> 10248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTTGATT

<400> 10248
cccctagaag gaaaaggaag                                                   20


<210> 10249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCAGTTT

<400> 10249
atgtctccaa gtctctgaaa                                                   20


<210> 10250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGATT

<400> 10250
acttctctga gcaaatataa                                                   20


<210> 10251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTAAGTTT

<400> 10251
agcaggggaa cttttttcat                                                   20


<210> 10252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CATTGCTT

<400> 10252
ccactcatcc aaagaatgga                                                   20


<210> 10253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGATT

<400> 10253
cagcacctgt ctgccccagc                                                   20


<210> 10254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGGGCTT

<400> 10254
gctgagcagt gggaatggag                                                   20


<210> 10255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCAGATT

<400> 10255
aagagaaaga catgatcata                                                   20


<210> 10256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGTTT

<400> 10256
tgagggtgat aaagtaccag                                                   20


<210> 10257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGAGTTT

<400> 10257
atgacacagg ctacagagta                                                   20


<210> 10258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGATT

<400> 10258
acaagtatgc tcagggaaca                                                   20


<210> 10259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGTGCTT

<400> 10259
gaatacagga ttgtcttatg                                                   20


<210> 10260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAGGATT

<400> 10260
tatacatcta actattgaat                                                   20


<210> 10261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGATT

<400> 10261
tataagatat atatatatat                                                   20


<210> 10262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAAGATT

<400> 10262
acaacacatg ggaattcaag                                                   20


<210> 10263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCATGATT

<400> 10263
agcatgggaa agacctgctc                                                   20


<210> 10264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TACAGCTT

<400> 10264
gaaagaggtt taattggact                                                   20


<210> 10265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAGGTTT

<400> 10265
ctgggcaatt tataaaagaa                                                   20


<210> 10266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTTGTTT

<400> 10266
tttcatactt ttcctttctt                                                   20


<210> 10267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGTTT

<400> 10267
ctgctttcat acttttcctt                                                   20


<210> 10268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCTGCTT

<400> 10268
tcatctatcc attcactatt                                                   20


<210> 10269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGTTT

<400> 10269
tcattcttct atctttccat                                                   20


<210> 10270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCATGCTT

<400> 10270
ttcacgcatc ttccatccaa                                                   20


<210> 10271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGATT

<400> 10271
aacccttata tctttctatc                                                   20


<210> 10272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TACTGATT

<400> 10272
actcatttca tccatcttcc                                                   20


<210> 10273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCTGCTT

<400> 10273
ccctttgggg gcacagtcac                                                   20


<210> 10274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAGGATT

<400> 10274
agcttcaggc cactgtacca                                                   20


<210> 10275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCAGCTT

<400> 10275
ttccctgatg ccaatgcact                                                   20


<210> 10276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGTGCTT

<400> 10276
tcaggaaatg tgtctgtatt                                                   20


<210> 10277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGGGTTT

<400> 10277
ctgttcactg ccgcatagct                                                   20


<210> 10278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGCTT

<400> 10278
actgtctagg ccactacctt                                                   20


<210> 10279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGATT

<400> 10279
gtgcttctca cacatcagac                                                   20


<210> 10280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGTGCTT

<400> 10280
cctgcattag agaattgact                                                   20


<210> 10281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGCTT

<400> 10281
gcagccatgg cttagaacca                                                   20


<210> 10282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CATGGCTT

<400> 10282
aggcatttcc aaggtgcagc                                                   20


<210> 10283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGATT

<400> 10283
gtgaccgacc accactaccc                                                   20


<210> 10284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGTTT

<400> 10284
cctcaagggc tactccaaag                                                   20


<210> 10285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGGGTTT

<400> 10285
agtggctcag tgggaacacg                                                   20


<210> 10286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TATGGCTT

<400> 10286
tgctgcttaa gtgggtggcc                                                   20


<210> 10287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGCTT

<400> 10287
ctttatcttt gtgttcgaga                                                   20


<210> 10288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGCTT

<400> 10288
ctggaccaga agcccacggt                                                   20


<210> 10289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCATGCTT

<400> 10289
ccccattggc cctgaagaag                                                   20


<210> 10290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCTGTTT

<400> 10290
atccctgcaa gtatcagcag                                                   20


<210> 10291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAGGTTT

<400> 10291
acttccaaaa tccaatttga                                                   20


<210> 10292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGCTT

<400> 10292
aactgcctgt gaacatccgt                                                   20


<210> 10293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGCGATT

<400> 10293
attctttttc agaggtgtgt                                                   20


<210> 10294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTTGATT

<400> 10294
tcttctttta atttgaattt                                                   20


<210> 10295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGGGTTT

<400> 10295
cccccacagc cacagcatcc                                                   20


<210> 10296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGCTT

<400> 10296
aatggcgtga acctgggagg                                                   20


<210> 10297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAGGTTT

<400> 10297
ttggcttcac acaggactgg                                                   20


<210> 10298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGCTT

<400> 10298
cctctgagtc acattgccaa                                                   20


<210> 10299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGTGCTT

<400> 10299
gcctccagtg tccttaggat                                                   20


<210> 10300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAGGATT

<400> 10300
accaacagcc tccagtgtcc                                                   20


<210> 10301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CACAGTTT

<400> 10301
taagcatttc ccaaggtgga                                                   20


<210> 10302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCGGCTT

<400> 10302
agatgtgggt tcagttgaaa                                                   20


<210> 10303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTATGTTT

<400> 10303
ataatttact caaccaatct                                                   20


<210> 10304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGCTT

<400> 10304
gctggtatac ctctttctca                                                   20


<210> 10305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAGGCTT

<400> 10305
ggcaccaaat ttagccttct                                                   20


<210> 10306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGCTT

<400> 10306
ttgtgggcct tctctcctca                                                   20


<210> 10307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTGGCTT

<400> 10307
ggtgctctcc tcactacgtc                                                   20


<210> 10308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTGGATT

<400> 10308
gctcttctcc ttccagtcct                                                   20


<210> 10309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGCTT

<400> 10309
aggggcaaga gagggctggg                                                   20


<210> 10310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGATT

<400> 10310
cccagtgccc tggcacaggg                                                   20


<210> 10311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGTTT

<400> 10311
gacgcaaagc caagggagaa                                                   20


<210> 10312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGCTT

<400> 10312
aaaactgctc ggtgcatggc                                                   20


<210> 10313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCAGATT

<400> 10313
atctaggcct ccatctaaat                                                   20


<210> 10314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGTTT

<400> 10314
gctcttccga ttcacggctg                                                   20


<210> 10315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCCGATT

<400> 10315
ctaggactac agtcccgctc                                                   20


<210> 10316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGGGCTT

<400> 10316
agtcaaagcc caaaggcatg                                                   20


<210> 10317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTTGTTT

<400> 10317
ggaaggaact taacatcctc                                                   20


<210> 10318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGCTT

<400> 10318
aaggaaggtt ctctctgtac                                                   20


<210> 10319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGCTT

<400> 10319
tctaaggccc tggctgaata                                                   20


<210> 10320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGAGATT

<400> 10320
ataacaaggc cttatgggaa                                                   20


<210> 10321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGCTT

<400> 10321
atttctaaca agctcccagg                                                   20


<210> 10322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGATT

<400> 10322
ctcccaggag cttgttcaaa                                                   20


<210> 10323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGCTT

<400> 10323
ttctcaaaat ttaatctccc                                                   20


<210> 10324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTGGCTT

<400> 10324
ccttatttaa tcccgaagcc                                                   20


<210> 10325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCAGCTT

<400> 10325
ccaacttgtc agtagcaaaa                                                   20


<210> 10326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGCTT

<400> 10326
actgacactc aaaatgttta                                                   20


<210> 10327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGTTT

<400> 10327
gatggggaaa ctgacactca                                                   20


<210> 10328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGCTT

<400> 10328
tcgtggagca cagctggttt                                                   20


<210> 10329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTGGTTT

<400> 10329
ctaccgtatc gtggagcaca                                                   20


<210> 10330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATGGTTT

<400> 10330
acaagtgggt ttcctagcag                                                   20


<210> 10331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGGGTTT

<400> 10331
tttttccaag ggcatgacaa                                                   20


<210> 10332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGATT

<400> 10332
tggagaggaa cacctgttgg                                                   20


<210> 10333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGTTT

<400> 10333
aggctcatac gccgtagctt                                                   20


<210> 10334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CGTAGCTT

<400> 10334
gcacccccag gctcatacgc                                                   20


<210> 10335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGGGCTT

<400> 10335
gtcgtggccc tcagttcagc                                                   20


<210> 10336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGCTT

<400> 10336
agccacgtcg tggccctcag                                                   20


<210> 10337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATAGTTT

<400> 10337
taaatacttg agtttttatt                                                   20


<210> 10338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGAGTTT

<400> 10338
aagaaaaatt ttttaaatac                                                   20


<210> 10339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAATGCTT

<400> 10339
tataaaggga attgtggcct                                                   20


<210> 10340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGTTT

<400> 10340
gtcttagtca tctttcctct                                                   20


<210> 10341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 10341
tgtatctgct tccctcaatc                                                   20


<210> 10342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGCTT

<400> 10342
ccagaggaag gccatgatgt                                                   20


<210> 10343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGATT

<400> 10343
ccataaacac cactgaaaac                                                   20


<210> 10344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAGGCTT

<400> 10344
gcccacttgc tgcctcactc                                                   20


<210> 10345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GACTGCTT

<400> 10345
atgacctgga agaaccagat                                                   20


<210> 10346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGCTT

<400> 10346
ggagagacga gttcactgcc                                                   20


<210> 10347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAGGTTT

<400> 10347
agcactccat caggggcccc                                                   20


<210> 10348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCATGATT

<400> 10348
caggcccctg cagcattact                                                   20


<210> 10349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAGGTTT

<400> 10349
tgggtccatt agcaaagcta                                                   20


<210> 10350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 10350
tctgggtgtt ggttttttgt                                                   20


<210> 10351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 10351
acaacttctg ggtgttggtt                                                   20


<210> 10352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTGGTTT

<400> 10352
tcagtacaca acttctgggt                                                   20


<210> 10353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAATGTTT

<400> 10353
cctggctagt tgtccctact                                                   20


<210> 10354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCATGCTT

<400> 10354
tcacattctg cacgtggatg                                                   20


<210> 10355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCCGCTT

<400> 10355
gggggctgtg ggtgaacaga                                                   20


<210> 10356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACGGGATT

<400> 10356
agataagagg gagggctggg                                                   20


<210> 10357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGCTT

<400> 10357
tccccaaagt tatcaagccc                                                   20


<210> 10358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGTTT

<400> 10358
atagggaaag aggcatctat                                                   20


<210> 10359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGTTT

<400> 10359
ttatacaagg taaaaataaa                                                   20


<210> 10360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAGGATT

<400> 10360
tgagctggaa gattagaggt                                                   20


<210> 10361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAGGTTT

<400> 10361
agagactgag ctggaagatt                                                   20


<210> 10362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGATT

<400> 10362
agcctcacag agactgagct                                                   20


<210> 10363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGTGATT

<400> 10363
acagatgaag aagttttccc                                                   20


<210> 10364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAAGTTT

<400> 10364
ttggaggtgc tcacagatga                                                   20


<210> 10365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGTTT

<400> 10365
taaatgagat gctgcttgtc                                                   20


<210> 10366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGCTT

<400> 10366
attttgaagc ttaaatgaga                                                   20


<210> 10367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAAGCTT

<400> 10367
cctacttggt aggattattt                                                   20


<210> 10368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTAGGATT

<400> 10368
tgaatggtaa tgcctacttg                                                   20


<210> 10369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCAGCTT

<400> 10369
gtccctgctg aggtaggtat                                                   20


<210> 10370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAAGATT

<400> 10370
aattttgaag ctgggaaaaa                                                   20


<210> 10371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGTGTTT

<400> 10371
tgagccaagc acttcgtgca                                                   20


<210> 10372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGCTT

<400> 10372
tactaagtgg tccagaaaag                                                   20


<210> 10373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCAGCTT

<400> 10373
attcttatgt gactcattta                                                   20


<210> 10374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCTGATT

<400> 10374
tttaccagca tcctaagaag                                                   20


<210> 10375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGATT

<400> 10375
gctctgtgca tgagatgcta                                                   20


<210> 10376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGGGATT

<400> 10376
aaaggccacc ttgaggtgct                                                   20


<210> 10377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGTGCTT

<400> 10377
gtgagcaaaa ggccaccttg                                                   20


<210> 10378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGCGTTT

<400> 10378
gccaagcttt ccagaggagt                                                   20


<210> 10379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAAGCTT

<400> 10379
ataaagaagt ttaaaccatg                                                   20


<210> 10380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAAGTTT

<400> 10380
cagaggagac cttgacataa                                                   20


<210> 10381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGGGCTT

<400> 10381
caggcagtgg ggaggggctt                                                   20


<210> 10382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGGGCTT

<400> 10382
gacagccaca ggcagtgggg                                                   20


<210> 10383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGCTT

<400> 10383
atgatggtgg ggaagatgct                                                   20


<210> 10384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGCTT

<400> 10384
atcgtaccaa acaggctctt                                                   20


<210> 10385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGTGCTT

<400> 10385
cccttccatt ccttctcttc                                                   20


<210> 10386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGAGATT

<400> 10386
ggccaatgtg gggctcagct                                                   20


<210> 10387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGCTT

<400> 10387
cccggtaggc caatgtgggg                                                   20


<210> 10388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATATGCTT

<400> 10388
ctcctccttt atggtggaaa                                                   20


<210> 10389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGGGCTT

<400> 10389
ccagagtcag gaacagagcc                                                   20


<210> 10390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAGGATT

<400> 10390
ctggaagcag caagatgtgc                                                   20


<210> 10391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGTTT

<400> 10391
atgcccctca ccctcagaca                                                   20


<210> 10392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGTTT

<400> 10392
ccaacttggg ttctttcctc                                                   20


<210> 10393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGCTT

<400> 10393
ccccagcctg gccccctgcc                                                   20


<210> 10394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCATGTTT

<400> 10394
aaataataac aaaatctact                                                   20


<210> 10395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GACTGATT

<400> 10395
tattcaggga agtaagagct                                                   20


<210> 10396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGGGTTT

<400> 10396
caagaaaata atgcttactc                                                   20


<210> 10397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAATGCTT

<400> 10397
tttccttaaa atcaagaaaa                                                   20


<210> 10398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATATGATT

<400> 10398
tgacttgcag gaatgagaac                                                   20


<210> 10399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGGGATT

<400> 10399
ttcaaacttt tcaaattcat                                                   20


<210> 10400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCAGATT

<400> 10400
ctttgatctg catttttatg                                                   20


<210> 10401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGCTT

<400> 10401
aaggcttctg ggttatctga                                                   20


<210> 10402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAGGCTT

<400> 10402
actgtctcct ggggaaagga                                                   20


<210> 10403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTGGATT

<400> 10403
cttccgtatc ctctgtggag                                                   20


<210> 10404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGTTT

<400> 10404
agctaccaaa acctgacggt                                                   20


<210> 10405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGTTT

<400> 10405
ccttgtgttt ttcccagatc                                                   20


<210> 10406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGTGTTT

<400> 10406
gtttaatggg atgagaggcc                                                   20


<210> 10407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTGGTTT

<400> 10407
aagcagtgtc cagaaaacgc                                                   20


<210> 10408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAAGCTT

<400> 10408
tggtctctct tcagtcataa                                                   20


<210> 10409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGATGTTT

<400> 10409
aagatgagaa atgccctaag                                                   20


<210> 10410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGTTT

<400> 10410
tccatgaaat catggacatt                                                   20


<210> 10411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGAGTTT

<400> 10411
tcttgtggga cttagcatat                                                   20


<210> 10412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGATT

<400> 10412
aacacataca tttttatgct                                                   20


<210> 10413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGCTT

<400> 10413
attttaaaac acatacattt                                                   20


<210> 10414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGATT

<400> 10414
ctgacagact gacagttgag                                                   20


<210> 10415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGGGATT

<400> 10415
acaggattaa acctcctccc                                                   20


<210> 10416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAGGATT

<400> 10416
catacagcac ttactgtata                                                   20


<210> 10417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGATT

<400> 10417
cccatatgag gagagtaact                                                   20


<210> 10418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGCTT

<400> 10418
cacagagttg ttgttttaag                                                   20


<210> 10419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTTGTTT

<400> 10419
ctgtgaccag tccacagagt                                                   20


<210> 10420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGTGTTT

<400> 10420
tactaatgct cagtttttat                                                   20


<210> 10421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGTTT

<400> 10421
ccccatacta gttactaatg                                                   20


<210> 10422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTACGTTT

<400> 10422
aaccttcggc aggccatgga                                                   20


<210> 10423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTAGGCTT

<400> 10423
aaagcaggga gaaattcctg                                                   20


<210> 10424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GATTGTTT

<400> 10424
ttttccttgc attctcctgg                                                   20


<210> 10425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGATT

<400> 10425
tcaattttcc ttgcattctc                                                   20


<210> 10426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTTGTTT

<400> 10426
atcctatatg agcaccactt                                                   20


<210> 10427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATAGTTT

<400> 10427
tcttaaacaa tttttgaggg                                                   20


<210> 10428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTTGTTT

<400> 10428
gactcattcc ttctgttttt                                                   20


<210> 10429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 10429
tgatgactca ttccttctgt                                                   20


<210> 10430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGTTT

<400> 10430
cactcttgat gactcattcc                                                   20


<210> 10431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGTTT

<400> 10431
ggaatgacta tttccacatc                                                   20


<210> 10432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CATAGTTT

<400> 10432
tagttttttt attctctgca                                                   20


<210> 10433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TATAGTTT

<400> 10433
cacaacttgt tattgttatc                                                   20


<210> 10434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGTTT

<400> 10434
atatactgac ttcttgaatc                                                   20


<210> 10435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAATGCTT

<400> 10435
tgtggacttc tttccattta                                                   20


<210> 10436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGTTT

<400> 10436
tctatccatc tttggtgttc                                                   20


<210> 10437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGATGCTT

<400> 10437
actgttattc cttcctttct                                                   20


<210> 10438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCAGCTT

<400> 10438
tccattgttg ctaatgagca                                                   20


<210> 10439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGTTT

<400> 10439
tgtttatctg aaatttgctc                                                   20


<210> 10440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGTTT

<400> 10440
gtgccttctg gccataacct                                                   20


<210> 10441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CACAGTTT

<400> 10441
atttcttcaa ccctttggag                                                   20


<210> 10442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TATTGATT

<400> 10442
tgtaagccta aaaatttagt                                                   20


<210> 10443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGATT

<400> 10443
ctttggaaca cagtttgagt                                                   20


<210> 10444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGAGTTT

<400> 10444
cttactcttt ggaacacagt                                                   20


<210> 10445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CACAGTTT

<400> 10445
tgatttctta ctctttggaa                                                   20


<210> 10446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TACTGATT

<400> 10446
actcaagaat ttttgtaagt                                                   20


<210> 10447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTTGTTT

<400> 10447
ggagtttcag tgtctcagca                                                   20


<210> 10448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGAGTTT

<400> 10448
ttcatcatca cacaagggga                                                   20


<210> 10449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCTGTTT

<400> 10449
cctggttcca attgatttca                                                   20


<210> 10450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGATT

<400> 10450
cagtcggcca tcctggttcc                                                   20


<210> 10451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCATGCTT

<400> 10451
gggcctgcac agttatctct                                                   20


<210> 10452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAGGTTT

<400> 10452
gtgattggtg gaaggaaagg                                                   20


<210> 10453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGTGATT

<400> 10453
gggtggatac cgggatttgc                                                   20


<210> 10454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCGGGATT

<400> 10454
aaatgtttag tgggtggata                                                   20


<210> 10455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGTTT

<400> 10455
aaggcagtat ttttattaga                                                   20


<210> 10456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGCTT

<400> 10456
caccaggctt ttgagaaaag                                                   20


<210> 10457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAGGCTT

<400> 10457
tggaagccaa gacgaggaca                                                   20


<210> 10458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCATGCTT

<400> 10458
atgtttattt agattcactc                                                   20


<210> 10459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGATT

<400> 10459
ttgtgtccac tcaatgttta                                                   20


<210> 10460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAATGTTT

<400> 10460
acattgttgt tgtgtccact                                                   20


<210> 10461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGGGTTT

<400> 10461
aaagggaaag aaaaagttca                                                   20


<210> 10462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTAGGATT

<400> 10462
tcaagtagcg cctcaaggat                                                   20


<210> 10463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGCTT

<400> 10463
tgtatgtctc acagcacatt                                                   20


<210> 10464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGCTT

<400> 10464
ttaagccagt gccacatagt                                                   20


<210> 10465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCAGCTT

<400> 10465
gacattccaa gccttctcct                                                   20


<210> 10466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CATAGATT

<400> 10466
atatttttgt cactgaataa                                                   20


<210> 10467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAGGTTT

<400> 10467
ttacaactga cccacaatac                                                   20


<210> 10468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGATT

<400> 10468
aatcgtcaag gctctaaact                                                   20


<210> 10469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTTGTTT

<400> 10469
ttactacaag ctttgctaag                                                   20


<210> 10470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAAGCTT

<400> 10470
acagtggcta caccattact                                                   20


<210> 10471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGCTT

<400> 10471
ttctcaattg ttctttattt                                                   20


<210> 10472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGTGCTT

<400> 10472
agacctctca ttgccacaca                                                   20


<210> 10473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGCTT

<400> 10473
acaattactt caaaaactta                                                   20


<210> 10474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGATT

<400> 10474
aaggcttttt cagtcaggga                                                   20


<210> 10475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGGGATT

<400> 10475
cagtgaaagg ctttttcagt                                                   20


<210> 10476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGCTT

<400> 10476
gttttaaggt ttaaacagtg                                                   20


<210> 10477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAGGTTT

<400> 10477
tggaaagcca aggtttgttt                                                   20


<210> 10478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTTGTTT

<400> 10478
tgggaaaatg gaaagccaag                                                   20


<210> 10479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAGGTTT

<400> 10479
cttgtgggaa aatggaaagc                                                   20


<210> 10480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCTGCTT

<400> 10480
atataacttc aaagtttgcc                                                   20


<210> 10481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGTTT

<400> 10481
gaaggaggcc aatataactt                                                   20


<210> 10482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGTTT

<400> 10482
actgagtaac tgaccccaat                                                   20


<210> 10483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGTTT

<400> 10483
tgataagtat tttaatttta                                                   20


<210> 10484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGATT

<400> 10484
gaggcggagg ttgcggtgag                                                   20


<210> 10485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGCTT

<400> 10485
ttgggaggct gagggaggag                                                   20


<210> 10486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGCTT

<400> 10486
tcaggagggt gaggcatgag                                                   20


<210> 10487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GATTGCTT

<400> 10487
ttgggaggcc aaggtgggag                                                   20


<210> 10488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAGGATT

<400> 10488
aattttggga ggccaaggtg                                                   20


<210> 10489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAAGATT

<400> 10489
caggttttgg tatcaaggtt                                                   20


<210> 10490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAGGTTT

<400> 10490
cctgactttc attgtccttg                                                   20


<210> 10491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAAGATT

<400> 10491
ttagtttgct aaaaatttgc                                                   20


<210> 10492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGCTT

<400> 10492
gaagatttag tttgctaaaa                                                   20


<210> 10493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGTTT

<400> 10493
ttttttaata cattggaaga                                                   20


<210> 10494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGATT

<400> 10494
gatgcatttt ttaatacatt                                                   20


<210> 10495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTAGCTT

<400> 10495
ctttacattc ccagctcaaa                                                   20


<210> 10496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGATT

<400> 10496
ttaaagtggt gaattatatt                                                   20


<210> 10497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGATGTTT

<400> 10497
caagaatatt tatcatgaat                                                   20


<210> 10498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCAGGCTT

<400> 10498
caccacctct aacaattgtg                                                   20


<210> 10499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGATT

<400> 10499
tgccttggcc tcctaaagtg                                                   20


<210> 10500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CGGGGTTT

<400> 10500
ctttgtattt ttagtagaga                                                   20


<210> 10501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGTTT

<400> 10501
cacatcatgt gaaaataaca                                                   20


<210> 10502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAATGTTT

<400> 10502
attctaataa tttatctata                                                   20


<210> 10503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAGGTTT

<400> 10503
aaagtttaaa aatgtttcca                                                   20


<210> 10504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGTTT

<400> 10504
agtctttcaa taaagtttaa                                                   20


<210> 10505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGTTT

<400> 10505
gctgtatacc agtctttcaa                                                   20


<210> 10506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TATTGTTT

<400> 10506
ccacatacac acaaaactgc                                                   20


<210> 10507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCAGCTT

<400> 10507
ccaatatcag tcttaattat                                                   20


<210> 10508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CATTGCTT

<400> 10508
ttccttctct cccaaaatag                                                   20


<210> 10509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GATTGATT

<400> 10509
gaactcaata aacacctgtt                                                   20


<210> 10510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTTGATT

<400> 10510
ataggaactc aataaacacc                                                   20


<210> 10511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TACCGTTT

<400> 10511
aaaaaccaga gtttcttgtc                                                   20


<210> 10512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGTTT

<400> 10512
ctatcccatg aggcaaaaac                                                   20


<210> 10513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTGGATT

<400> 10513
ccccaaccac actatctaaa                                                   20


<210> 10514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAAGTTT

<400> 10514
acttcttggc tttgggcctt                                                   20


<210> 10515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGCTT

<400> 10515
tcacacataa cagagaactt                                                   20


<210> 10516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTGGTTT

<400> 10516
catttgttac aaataacttc                                                   20


<210> 10517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGTTT

<400> 10517
cacacacaca cacacacaca                                                   20


<210> 10518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGCTT

<400> 10518
aaactggagc agattgaaca                                                   20


<210> 10519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCAGATT

<400> 10519
ttcagttttc agaaaactgg                                                   20


<210> 10520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGTTT

<400> 10520
actttatttt caggacagtt                                                   20


<210> 10521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GACAGTTT

<400> 10521
ttaatagact ttattttcag                                                   20


<210> 10522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTGGTTT

<400> 10522
caccgccagc tggtcagttt                                                   20


<210> 10523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCAGTTT

<400> 10523
agaaaaatca ccgccagctg                                                   20


<210> 10524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGTGTTT

<400> 10524
ccctctgcct ctttgcgttt                                                   20


<210> 10525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGCGTTT

<400> 10525
caccttttcc ctctgcctct                                                   20


<210> 10526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTAGATT

<400> 10526
ccacttccct catgacctag                                                   20


<210> 10527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTAGCTT

<400> 10527
ctattccact tccctcatga                                                   20


<210> 10528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CGCTGATT

<400> 10528
atgctaccct gtccccacct                                                   20


<210> 10529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAGGATT

<400> 10529
ttacttcaca gtctgcccct                                                   20


<210> 10530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCAAGTTT

<400> 10530
tcccaaacaa ccaaaaatag                                                   20


<210> 10531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGTGTTT

<400> 10531
cacttgggga agcagaagct                                                   20


<210> 10532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAAGCTT

<400> 10532
tctgctacac ttggggaagc                                                   20


<210> 10533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCGAGATT

<400> 10533
gaggcggagc ttacagtgag                                                   20


<210> 10534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CGGAGCTT

<400> 10534
aatggcgtga acctgggagg                                                   20


<210> 10535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTAGTTT

<400> 10535
cataccctgg caggcccaca                                                   20


<210> 10536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GACAGATT

<400> 10536
ttaaatcaca tttttagaag                                                   20


<210> 10537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGTTT

<400> 10537
tctttaatat tggctactaa                                                   20


<210> 10538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGATT

<400> 10538
ttttccaaaa aagtcagaaa                                                   20


<210> 10539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GATCGCTT

<400> 10539
ttgggaggcc gaggcaggca                                                   20


<210> 10540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGATGTTT

<400> 10540
cagtgcacaa ctcctgggag                                                   20


<210> 10541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTGGATT

<400> 10541
gagcccctga acttggcgta                                                   20


<210> 10542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGCTT

<400> 10542
gcaacgagac tctaggacag                                                   20


<210> 10543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CACGGCTT

<400> 10543
aaagaggcct gaagaaatgt                                                   20


<210> 10544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGCTT

<400> 10544
aggtctccag gccatctgga                                                   20


<210> 10545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCAGATT

<400> 10545
caggtttgtc agccaaacct                                                   20


<210> 10546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAGGTTT

<400> 10546
cacccacttt tatcagagcc                                                   20


<210> 10547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGATT

<400> 10547
ccagcctcaa ggaagtcatt                                                   20


<210> 10548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTCGTTT

<400> 10548
tcacaacaac cctgagagat                                                   20


<210> 10549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCAGCTT

<400> 10549
tggagacttg ggtctgtggc                                                   20


<210> 10550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCAGATT

<400> 10550
atggcttggg gaaactccca                                                   20


<210> 10551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGCTT

<400> 10551
cttggtaatg tttttctctt                                                   20


<210> 10552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAATGTTT

<400> 10552
gctgcggagc ttccgcttgg                                                   20


<210> 10553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCCGCTT

<400> 10553
gcctgtctgt gctgcggagc                                                   20


<210> 10554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CGGAGCTT

<400> 10554
agggaagcct gtctgtgctg                                                   20


<210> 10555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTTGTTT

<400> 10555
cagatcccac tgtgatgaaa                                                   20


<210> 10556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGCTT

<400> 10556
cccacagatc ccactgtgat                                                   20


<210> 10557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGATT

<400> 10557
catagcaact gaacaaaaca                                                   20


<210> 10558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCCGCTT

<400> 10558
taataatgat cttaaagact                                                   20


<210> 10559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACACGTTT

<400> 10559
tctgtgatgt cccacaaccc                                                   20


<210> 10560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGATT

<400> 10560
taagctagga aatgtctggg                                                   20


<210> 10561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAAGCTT

<400> 10561
aggaaggatg cattatttgt                                                   20


<210> 10562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CGTTGCTT

<400> 10562
gaaaagcacc tgaccctggt                                                   20


<210> 10563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGTTT

<400> 10563
ctccataaga aggatgcatt                                                   20


<210> 10564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCTGTTT

<400> 10564
gaaagtcact taaactctca                                                   20


<210> 10565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGTGCTT

<400> 10565
cttggtgcct gcaatgagtc                                                   20


<210> 10566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGCTT

<400> 10566
ttttttaaag caagaaagtc                                                   20


<210> 10567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAATGCTT

<400> 10567
ggaaaaatgg aaagagaaga                                                   20


<210> 10568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCATGTTT

<400> 10568
catggtggaa tcagcatgcc                                                   20


<210> 10569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGCTT

<400> 10569
agaactgtct ggctttgggg                                                   20


<210> 10570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGCTT

<400> 10570
tactggattc accagaactg                                                   20


<210> 10571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTGGATT

<400> 10571
caccaagctg gaggtgacct                                                   20


<210> 10572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCCGCTT

<400> 10572
ccagacagac cggctgccaa                                                   20


<210> 10573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGAGTTT

<400> 10573
atcttcccaa gatcatagag                                                   20


<210> 10574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CATGGATT

<400> 10574
aataatactc agatgcttct                                                   20


<210> 10575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGATGCTT

<400> 10575
caggaatagt aataatactc                                                   20


<210> 10576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTGGATT

<400> 10576
cttaacaaga tacaatccat                                                   20


<210> 10577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGCTT

<400> 10577
ggcatctagt ttagacatca                                                   20


<210> 10578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGTTT

<400> 10578
gtcggaactt ttctttggca                                                   20


<210> 10579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCACGATT

<400> 10579
atgaccacaa ttaacagtag                                                   20


<210> 10580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGTTT

<400> 10580
taaagacaat ctttggactt                                                   20


<210> 10581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATGGCTT

<400> 10581
acccaggctg agctggtggg                                                   20


<210> 10582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGGGCTT

<400> 10582
gaagctcaag acaattctct                                                   20


<210> 10583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGATT

<400> 10583
ttgtctcaga agtatctgat                                                   20


<210> 10584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCAGCTT

<400> 10584
agaagtgccc accctgcttg                                                   20


<210> 10585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCTGCTT

<400> 10585
agtctgaaca gaagtgccca                                                   20


<210> 10586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCAGTTT

<400> 10586
cagtaaaaat atgtaatgtc                                                   20


<210> 10587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAGGTTT

<400> 10587
aaattgggtc tattcacagt                                                   20


<210> 10588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCAGATT

<400> 10588
gaatataata tagaaacaca                                                   20


<210> 10589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGATT

<400> 10589
aggtggactt gcagatatgc                                                   20


<210> 10590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCATGTTT

<400> 10590
aaagccgcga gataattaaa                                                   20


<210> 10591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCAGATT

<400> 10591
tgaatttgga agcagttaaa                                                   20


<210> 10592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTGGTTT

<400> 10592
gtccccagag ccaaatgaac                                                   20


<210> 10593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAATGCTT

<400> 10593
acacagagaa gctaaggtga                                                   20


<210> 10594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGATT

<400> 10594
agagatggtt ttttagggct                                                   20


<210> 10595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGTTT

<400> 10595
ttggtgggaa ttggcataga                                                   20


<210> 10596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGAGATT

<400> 10596
aacacagtta cacatccaca                                                   20


<210> 10597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTTGTTT

<400> 10597
atgtattatg ctttatcagt                                                   20


<210> 10598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGCTT

<400> 10598
tcattctttt tcacaatgta                                                   20


<210> 10599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGTTT

<400> 10599
ctggtgcacc cccctcccac                                                   20


<210> 10600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AACTGATT

<400> 10600
ggcacacagt tatttctcta                                                   20


<210> 10601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGCTT

<400> 10601
tttccaagcc ttgtagtgag                                                   20


<210> 10602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGTTT

<400> 10602
aaaataaatt tcaaatgcac                                                   20


<210> 10603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGATT

<400> 10603
tgtagtttct aaaatccagt                                                   20


<210> 10604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTAGTTT

<400> 10604
gctttgccag tttggacatc                                                   20


<210> 10605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCAGTTT

<400> 10605
tctttagaga actatgcttt                                                   20


<210> 10606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTATGCTT

<400> 10606
gtgccaactt ctttagagaa                                                   20


<210> 10607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTTGATT

<400> 10607
cttttgttcc aaacagggat                                                   20


<210> 10608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGGGATT

<400> 10608
gttcttgctt ttgttccaaa                                                   20


<210> 10609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGCTT

<400> 10609
caaaataggt ccagggaagt                                                   20


<210> 10610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGCTT

<400> 10610
tcctcattca tgactacttc                                                   20


<210> 10611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCTGCTT

<400> 10611
tcccatcatg cctcacaggt                                                   20


<210> 10612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCTGTTT

<400> 10612
atcaagttca acaatgtcaa                                                   20


<210> 10613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCATGTTT

<400> 10613
cttttgaggt ggggccatgg                                                   20


<210> 10614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAAGATT

<400> 10614
tctgggagaa taagagagac                                                   20


<210> 10615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTTGTTT

<400> 10615
gggggagttt ttgtttgttt                                                   20


<210> 10616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTTGTTT

<400> 10616
gtttggggga gtttttgttt                                                   20


<210> 10617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTTGTTT

<400> 10617
ttgtgtttgg gggagttttt                                                   20


<210> 10618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 10618
gtttttgtgt ttgggggagt                                                   20


<210> 10619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGAGTTT

<400> 10619
tttttggttt ttgtgtttgg                                                   20


<210> 10620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGTGTTT

<400> 10620
gaaagaagac tttttggttt                                                   20


<210> 10621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGTTT

<400> 10621
ggagaattga aagaagactt                                                   20


<210> 10622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAAGTTT

<400> 10622
gtgtacagac aattttttca                                                   20


<210> 10623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGGGCTT

<400> 10623
gtaggcagag gtcatattga                                                   20


<210> 10624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAGGATT

<400> 10624
tctttggtga tctaagcaaa                                                   20


<210> 10625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGGGCTT

<400> 10625
aatgaaacat gaaaaggtcc                                                   20


<210> 10626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGTTT

<400> 10626
agacacagtt ctaacaaact                                                   20


<210> 10627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCAGTTT

<400> 10627
tgtatatata tatatttgaa                                                   20


<210> 10628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGGGTTT

<400> 10628
tgagttgagt ctgggatata                                                   20


<210> 10629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAAGATT

<400> 10629
ctttaatggg gaaagatgaa                                                   20


<210> 10630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGGGCTT

<400> 10630
ggagcatttt aggggaagaa                                                   20


<210> 10631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAAGATT

<400> 10631
atgagagcta tctaaggggc                                                   20


<210> 10632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGCTT

<400> 10632
ggaagccaag tacaagatgg                                                   20


<210> 10633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGATT

<400> 10633
aagaggagtg aggtgccatt                                                   20


<210> 10634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTAAGATT

<400> 10634
aggatactaa gtgaaatatg                                                   20


<210> 10635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGAGCTT

<400> 10635
ccagaagctg ggtcacagca                                                   20


<210> 10636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGATT

<400> 10636
ttctatgctt ggcatgcaag                                                   20


<210> 10637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTATGCTT

<400> 10637
actcaaagca tgtgaacctt                                                   20


<210> 10638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGTTT

<400> 10638
aaagtttggc ccaaaccaac                                                   20


<210> 10639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGTTT

<400> 10639
ttaagaggga ttatgcttaa                                                   20


<210> 10640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGCTT

<400> 10640
ggccacctct ttaagaggga                                                   20


<210> 10641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGGGATT

<400> 10641
tataaaggcc acctctttaa                                                   20


<210> 10642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAGGATT

<400> 10642
ttcatgctgc cagagtcgta                                                   20


<210> 10643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGATGCTT

<400> 10643
acacacatga gacacctgaa                                                   20


<210> 10644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGTTT

<400> 10644
ttaggttaaa taaaagaggt                                                   20


<210> 10645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGTTT

<400> 10645
aagaaaggcc agagaaacaa                                                   20


<210> 10646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGTTT

<400> 10646
atctatgagg gcggagatgt                                                   20


<210> 10647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGATT

<400> 10647
atactcatca catttggcta                                                   20


<210> 10648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGCTT

<400> 10648
taaatgagtc aggtcaagca                                                   20


<210> 10649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAGGATT

<400> 10649
acttatcttg tagagttttg                                                   20


<210> 10650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGAGTTT

<400> 10650
gtgagaatat acttatcttg                                                   20


<210> 10651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGATT

<400> 10651
cttcagtaac ttttctgtgc                                                   20


<210> 10652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGAGCTT

<400> 10652
tatggtacac agtgtgacct                                                   20


<210> 10653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGTTT

<400> 10653
ctgctctgga acccggctgc                                                   20


<210> 10654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAAGCTT

<400> 10654
ggattcagtg gtgaactgat                                                   20


<210> 10655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGATT

<400> 10655
gtgtggcatt gcttcaggtg                                                   20


<210> 10656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CATTGCTT

<400> 10656
agcccctgtt gtgtgtgtgg                                                   20


<210> 10657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAAGCTT

<400> 10657
tcatttattc tcgaaaactg                                                   20


<210> 10658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTTGTTT

<400> 10658
gcaaacattg aatacaaaca                                                   20


<210> 10659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AACAGTTT

<400> 10659
aacagcaaac attgaataca                                                   20


<210> 10660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 10660
ttttgtttgt ttgttttggt                                                   20


<210> 10661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGTTT

<400> 10661
cttggttttt gtttgtttgt                                                   20


<210> 10662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTTGTTT

<400> 10662
aggtttcttg gtttttgttt                                                   20


<210> 10663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTTGTTT

<400> 10663
agataggttt cttggttttt                                                   20


<210> 10664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 10664
ggccagatag gtttcttggt                                                   20


<210> 10665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGTTT

<400> 10665
tttcttggcc agataggttt                                                   20


<210> 10666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAGGTTT

<400> 10666
acaatttctt tcttggccag                                                   20


<210> 10667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGTGCTT

<400> 10667
catttcttgc atacctgagt                                                   20


<210> 10668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGTTT

<400> 10668
aagttacatt tcttgcatac                                                   20


<210> 10669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAGGTTT

<400> 10669
aggaccagct caactctcct                                                   20


<210> 10670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATACGCTT

<400> 10670
ggagctacaa ctcaggcaaa                                                   20


<210> 10671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTAGCTT

<400> 10671
aaaatctggg gaaaggcaac                                                   20


<210> 10672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGACGTTT

<400> 10672
aagaaaggca ggagaaacaa                                                   20


<210> 10673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGTTT

<400> 10673
taccagatat gcagagatgt                                                   20


<210> 10674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGATT

<400> 10674
cagaggtggc aagccttaga                                                   20


<210> 10675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGGGATT

<400> 10675
tagaaaccaa aaaaatgttt                                                   20


<210> 10676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGTTT

<400> 10676
gtgagcaata gaaaccaaaa                                                   20


<210> 10677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGTGTTT

<400> 10677
tgcccctgag aaggagtcct                                                   20


<210> 10678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGAGCTT

<400> 10678
ctaggctgga ggagttgtaa                                                   20


<210> 10679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCGTGATT

<400> 10679
tccacacact ttgccataga                                                   20


<210> 10680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CATGGTTT

<400> 10680
catggcaaaa ttatcctttt                                                   20


<210> 10681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTAGATT

<400> 10681
tgctttgcat gcatcacaaa                                                   20


<210> 10682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGCTT

<400> 10682
catctcttgt tcaaattagc                                                   20


<210> 10683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGTTT

<400> 10683
gccccaccat cttttatcaa                                                   20


<210> 10684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGTTT

<400> 10684
aggttaaagg agcgtcctga                                                   20


<210> 10685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGATT

<400> 10685
taagtgacat atgactatat                                                   20


<210> 10686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGTTT

<400> 10686
gatgtataga aggctatagc                                                   20


<210> 10687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TACAGATT

<400> 10687
tattcagcaa taacatgctg                                                   20


<210> 10688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AACTGTTT

<400> 10688
aaactttctt tatgtttatt                                                   20


<210> 10689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGTTT

<400> 10689
ggaagcttta taaactttct                                                   20


<210> 10690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGCTT

<400> 10690
tttgcttagt cctcatggtt                                                   20


<210> 10691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGCTT

<400> 10691
aaatagtgac tactagtatc                                                   20


<210> 10692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGTTT

<400> 10692
ctccttatct ccccttgtaa                                                   20


<210> 10693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGTTT

<400> 10693
aagattgact ctttaggccc                                                   20


<210> 10694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGATT

<400> 10694
agttaaatta ccaggctagt                                                   20


<210> 10695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTTGATT

<400> 10695
catgtgtcta gatattctga                                                   20


<210> 10696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGATT

<400> 10696
ccaccctcct ttctctgttc                                                   20


<210> 10697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGCTT

<400> 10697
agtatttaca gaggtgtggg                                                   20


<210> 10698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGTTT

<400> 10698
cactccgatg ggctaataga                                                   20


<210> 10699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGATT

<400> 10699
tcagtctctg actcaatgtc                                                   20


<210> 10700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGTGTTT

<400> 10700
agtttcagca atgatgtttc                                                   20


<210> 10701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGTTT

<400> 10701
ctcccctcca gtttcagcaa                                                   20


<210> 10702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGTTT

<400> 10702
agttaatgtg agctctcccc                                                   20


<210> 10703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTGGATT

<400> 10703
tggcaagtca gggattcctc                                                   20


<210> 10704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGGGATT

<400> 10704
cgcagagtgt aatggcaagt                                                   20


<210> 10705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTTGCTT

<400> 10705
ctgaatagaa gcacagtatt                                                   20


<210> 10706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGTTT

<400> 10706
atggcaccca gagaaattca                                                   20


<210> 10707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCTGCTT

<400> 10707
aaactgaagg acccttctct                                                   20


<210> 10708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCTGCTT

<400> 10708
catcactgcc tcagtgatag                                                   20


<210> 10709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGCTT

<400> 10709
tttgacccca tatttcttat                                                   20


<210> 10710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTGGTTT

<400> 10710
gcctgaggtc aaacaggttt                                                   20


<210> 10711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAGGTTT

<400> 10711
ttgagttggc ctgaggtcaa                                                   20


<210> 10712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGATT

<400> 10712
agatgagacc cagagagaga                                                   20


<210> 10713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAATGCTT

<400> 10713
cgatgtctcg gtgagtttgt                                                   20


<210> 10714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGAGTTT

<400> 10714
ctggagctgt cgatgtctcg                                                   20


<210> 10715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGAGCTT

<400> 10715
acaccaaccg ccgcccacta                                                   20


<210> 10716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCAGTTT

<400> 10716
ggctctagat ttcccagagg                                                   20


<210> 10717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGATT

<400> 10717
ggtagaggga agtgttgggc                                                   20


<210> 10718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTAGATT

<400> 10718
catgcatacc tagaataccc                                                   20


<210> 10719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAGGTTT

<400> 10719
caactgaact atccaggtga                                                   20


<210> 10720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GACAGCTT

<400> 10720
atgtggaaaa gtgaacttag                                                   20


<210> 10721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TATTGATT

<400> 10721
agattttgat gggaaatgtt                                                   20


<210> 10722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGTTT

<400> 10722
caatggaaga ttttgatggg                                                   20


<210> 10723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGATT

<400> 10723
agccacacag ttccctcaat                                                   20


<210> 10724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGTTT

<400> 10724
acactaattc tctgagggct                                                   20


<210> 10725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAAGTTT

<400> 10725
caaatgatgg tttattatgg                                                   20


<210> 10726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGTTT

<400> 10726
gaccacctga ggacacaaat                                                   20


<210> 10727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGATT

<400> 10727
agtttggtat gaagtcaatg                                                   20


<210> 10728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAATGTTT

<400> 10728
atcagagttt ggtatgaagt                                                   20


<210> 10729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGTTT

<400> 10729
gtggaataaa tcggtatgat                                                   20


<210> 10730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTAGCTT

<400> 10730
ttggcaagat tctccacttt                                                   20


<210> 10731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCAAGATT

<400> 10731
agtaaggaga accccaattg                                                   20


<210> 10732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGGGATT

<400> 10732
aacttcagtt ctgtgagata                                                   20


<210> 10733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAGGCTT

<400> 10733
ataatggttg ctaaacagga                                                   20


<210> 10734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGCTT

<400> 10734
agagtactct atttataata                                                   20


<210> 10735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAGGATT

<400> 10735
ctcatttgct tcaaaaattg                                                   20


<210> 10736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGCTT

<400> 10736
tggatgtgtc aatttttctc                                                   20


<210> 10737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTTGCTT

<400> 10737
tcttctcagt ttcttcattg                                                   20


<210> 10738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTGGTTT

<400> 10738
attttcttct cagtttcttc                                                   20


<210> 10739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGTTT

<400> 10739
tatgcaacca aaattttctt                                                   20


<210> 10740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAATGCTT

<400> 10740
gatgaatttt aaagcaattc                                                   20


<210> 10741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGGGTTT

<400> 10741
aatatataga agagacccag                                                   20


<210> 10742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGTTT

<400> 10742
catgtggtaa atagacctaa                                                   20


<210> 10743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGATT

<400> 10743
ttaagtactt ctttaatgct                                                   20


<210> 10744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGTTT

<400> 10744
tctagtaatt gaagacttga                                                   20


<210> 10745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGCTT

<400> 10745
ggggctggat aggtatcaga                                                   20


<210> 10746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGTGTTT

<400> 10746
gtgtattaga gacacataca                                                   20


<210> 10747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAGGATT

<400> 10747
ctagaacatg ttcttttccc                                                   20


<210> 10748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGTGCTT

<400> 10748
cttgttcatt caacaatact                                                   20


<210> 10749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGCTT

<400> 10749
atgtgtgctt gtctctccag                                                   20


<210> 10750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGTGCTT

<400> 10750
ggatgtccaa taattggtat                                                   20


<210> 10751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CACAGATT

<400> 10751
cccccattct gtcagcccca                                                   20


<210> 10752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGGGCTT

<400> 10752
gaaatgtcaa tgacactgaa                                                   20


<210> 10753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CACAGCTT

<400> 10753
aatcacagaa caggatgaat                                                   20


<210> 10754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGCTT

<400> 10754
tgcatctgtg ccctcctctt                                                   20


<210> 10755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGATT

<400> 10755
gcaataccat ctctccaacc                                                   20


<210> 10756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGCTT

<400> 10756
ggatcaacat ggctattttt                                                   20


<210> 10757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCACGCTT

<400> 10757
ttgcactgca actttcctcg                                                   20


<210> 10758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATGGCTT

<400> 10758
gtgacacaat ccagcctggg                                                   20


<210> 10759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGTTT

<400> 10759
ctgtcacctg ttgttatcag                                                   20


<210> 10760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTAGTTT

<400> 10760
aggtggtttt tattttttta                                                   20


<210> 10761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTGGTTT

<400> 10761
ttttttttct gatgcgtcga                                                   20


<210> 10762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCAGCTT

<400> 10762
ggtgtctgcg gacatcaaag                                                   20


<210> 10763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCGGTTT

<400> 10763
gaggacactg gaggaagaac                                                   20


<210> 10764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGTGATT

<400> 10764
ggattgggca atcaaatggg                                                   20


<210> 10765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAGGATT

<400> 10765
tccaatttga ctcccaggtt                                                   20


<210> 10766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAGGTTT

<400> 10766
aggggagtcc aatttgactc                                                   20


<210> 10767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGGGATT

<400> 10767
agggaagtgg atcaacaaga                                                   20


<210> 10768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAAGATT

<400> 10768
caccttaggg aagtggatca                                                   20


<210> 10769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGATT

<400> 10769
agaggctcag gtttgtgctc                                                   20


<210> 10770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAGGTTT

<400> 10770
agcgcaggat ggtaagaggc                                                   20


<210> 10771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGGGATT

<400> 10771
ttcgcaggtg ctagcagcac                                                   20


<210> 10772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGTTT

<400> 10772
tggtcctaac ccttcagctt                                                   20


<210> 10773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGCTT

<400> 10773
caccaccctg gtcctaaccc                                                   20


<210> 10774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCAGCTT

<400> 10774
tcctaccttg aggcaagggg                                                   20


<210> 10775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGCTT

<400> 10775
gttctcagct agagaccagc                                                   20


<210> 10776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCAGCTT

<400> 10776
aggagtgttc tcagctagag                                                   20


<210> 10777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAGGATT

<400> 10777
ttctcaaaga agaagctaag                                                   20


<210> 10778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAGGTTT

<400> 10778
gcctcaggga ccatattaga                                                   20


<210> 10779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CACCGTTT

<400> 10779
actagccact tcaattaggg                                                   20


<210> 10780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGCTT

<400> 10780
gcaggaggtt tgtgaggagt                                                   20


<210> 10781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAGGTTT

<400> 10781
gagatgctcc ggaaggagca                                                   20


<210> 10782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAGGTTT

<400> 10782
ggggtccatg tgctatgggt                                                   20


<210> 10783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGCTT

<400> 10783
ctggtgggtc agctgcatgg                                                   20


<210> 10784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAGGATT

<400> 10784
tcactgttcc gcctcatgac                                                   20


<210> 10785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGGGCTT

<400> 10785
accagctttg attcctttgc                                                   20


<210> 10786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGCTT

<400> 10786
aactacacca gctttgattc                                                   20


<210> 10787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGATT

<400> 10787
ccggatttta actacaccag                                                   20


<210> 10788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCAGCTT

<400> 10788
acaacccgga ttttaactac                                                   20


<210> 10789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCGGATT

<400> 10789
tgccttaaaa cttctgacaa                                                   20


<210> 10790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCCGTTT

<400> 10790
tgacgtgaaa gtattagcgt                                                   20


<210> 10791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGCTT

<400> 10791
ttccctggta tgaactggca                                                   20


<210> 10792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAGGTTT

<400> 10792
tgcagatgat gccaacaggc                                                   20


<210> 10793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGTGTTT

<400> 10793
aacattgagt gattaaatta                                                   20


<210> 10794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGTGATT

<400> 10794
atctgtaaag aaagaacatt                                                   20


<210> 10795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCAGATT

<400> 10795
caactgactt ctttctgacc                                                   20


<210> 10796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CGTAGTTT

<400> 10796
aataaatata ttgacacctg                                                   20


<210> 10797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGATGCTT

<400> 10797
tttacgctcc ctgagctgac                                                   20


<210> 10798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGTTT

<400> 10798
ctggacttca aacgaggcat                                                   20


<210> 10799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AACTGATT

<400> 10799
cgaagtggag atagacttgg                                                   20


<210> 10800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTGGATT

<400> 10800
tgtttatatg cagtggctat                                                   20


<210> 10801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AACTGTTT

<400> 10801
atttaatcct cagagcagtg                                                   20


<210> 10802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGTTT

<400> 10802
aaacaatagg aattttcctt                                                   20


<210> 10803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCAGCTT

<400> 10803
ttattccagt ttatcctttc                                                   20


<210> 10804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGTTT

<400> 10804
tgttcttcca catatattat                                                   20


<210> 10805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCAGTTT

<400> 10805
catgagaggg ttgttctgac                                                   20


<210> 10806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGCTT

<400> 10806
tctcacccac ctccatggct                                                   20


<210> 10807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGCTT

<400> 10807
gaggacccct cagctctgcc                                                   20


<210> 10808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GATAGTTT

<400> 10808
tccaggctgg gtgaatacga                                                   20


<210> 10809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGAGCTT

<400> 10809
tcctggaggt ggtgtttgag                                                   20


<210> 10810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGTGTTT

<400> 10810
tagggaaggc ttcctggagg                                                   20


<210> 10811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAGGCTT

<400> 10811
gaggcaagag agaaagtagg                                                   20


<210> 10812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAGGCTT

<400> 10812
tggaaaacaa gttctttact                                                   20


<210> 10813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTAGTTT

<400> 10813
ccaaatccag cctataagct                                                   20


<210> 10814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGATT

<400> 10814
tttaaaatag agataggaaa                                                   20


<210> 10815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGTTT

<400> 10815
gccatgtgga aatgtgggtt                                                   20


<210> 10816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGCTT

<400> 10816
gggacagccc cactgctcgg                                                   20


<210> 10817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCAGATT

<400> 10817
aatttcgaat tcttacagag                                                   20


<210> 10818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTAGGCTT

<400> 10818
tttgcaaggc ttcttcaggc                                                   20


<210> 10819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAGGCTT

<400> 10819
agaaaaacag tggaagtttg                                                   20


<210> 10820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGTTT

<400> 10820
agtgttccca gaaaaacagt                                                   20


<210> 10821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCATGATT

<400> 10821
aaaacaacaa tgtatttaat                                                   20


<210> 10822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTAGCTT

<400> 10822
catggggagg gaatgtatga                                                   20


<210> 10823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAGGCTT

<400> 10823
ggagggttca gaaccatctg                                                   20


<210> 10824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAGGCTT

<400> 10824
ggaatattgc attcaccaca                                                   20


<210> 10825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGCTT

<400> 10825
gggagattga gagccgaagt                                                   20


<210> 10826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGAGATT

<400> 10826
agtcattcta cctctgctgg                                                   20


<210> 10827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGTGTTT

<400> 10827
gccaaaatgg ttctcttgag                                                   20


<210> 10828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGTGTTT

<400> 10828
atcctcacca tcttctgcct                                                   20


<210> 10829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCTGATT

<400> 10829
cctgaaggtc attgtggggg                                                   20


<210> 10830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCAAGCTT

<400> 10830
gcctgcctct cagagtaaat                                                   20


<210> 10831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTAGCTT

<400> 10831
caaattactg gggtgaagtt                                                   20


<210> 10832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 10832
ttttctttct cttggtctat                                                   20


<210> 10833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGTTT

<400> 10833
ttctattgct aaactcacct                                                   20


<210> 10834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGTTT

<400> 10834
ttatgcccca gtgactgtct                                                   20


<210> 10835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGCTT

<400> 10835
gtatccttct ttgctgccag                                                   20


<210> 10836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTTGATT

<400> 10836
cgaagctgct ctcccaaaga                                                   20


<210> 10837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GATTGCTT

<400> 10837
ctaaccaaaa ataaatccta                                                   20


<210> 10838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTAGATT

<400> 10838
atgactaacc aaaaataaat                                                   20


<210> 10839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTGGATT

<400> 10839
gactgacaca tgtagtgctc                                                   20


<210> 10840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTGGTTT

<400> 10840
tgccaaggtt ttacctcctc                                                   20


<210> 10841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAGGTTT

<400> 10841
ctcattcctc agggctctgc                                                   20


<210> 10842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGCTT

<400> 10842
aaactttctg aaatgggact                                                   20


<210> 10843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGATT

<400> 10843
ggaaaaaaga attaggcaat                                                   20


<210> 10844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGTTT

<400> 10844
gaaagcagtc ccagtatctt                                                   20


<210> 10845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGATT

<400> 10845
ttttatttat accttaaact                                                   20


<210> 10846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGGGATT

<400> 10846
cttcactttc tgttctggtt                                                   20


<210> 10847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTGGTTT

<400> 10847
catttattca cagagcatat                                                   20


<210> 10848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AACAGTTT

<400> 10848
agagttctta gagcattaaa                                                   20


<210> 10849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTTGCTT

<400> 10849
gctgcatgca tccccaggac                                                   20


<210> 10850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTAGATT

<400> 10850
agtctataga tggcagtgtc                                                   20


<210> 10851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGTTT

<400> 10851
gagactggtt ggtcaaactc                                                   20


<210> 10852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAAGATT

<400> 10852
accgcttcgg gggttgcttt                                                   20


<210> 10853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTTGCTT

<400> 10853
ccacagagta ccgcttcggg                                                   20


<210> 10854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TACCGCTT

<400> 10854
ctggggttct tgccacagag                                                   20


<210> 10855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGCTT

<400> 10855
aagaaggttc ttcatctcag                                                   20


<210> 10856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGGGCTT

<400> 10856
gatttgcatg ggtgtccatg                                                   20


<210> 10857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGATT

<400> 10857
tattgaaata aaataaaata                                                   20


<210> 10858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCTGTTT

<400> 10858
tttctgtgca acccaacacc                                                   20


<210> 10859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CACAGTTT

<400> 10859
catatgcatg cttatagcag                                                   20


<210> 10860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCATGCTT

<400> 10860
ttaaaaagac acttgcatat                                                   20


<210> 10861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGAGATT

<400> 10861
aaccactaag gaaaacgtta                                                   20


<210> 10862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTATGCTT

<400> 10862
gagagaaaaa tctttgttat                                                   20


<210> 10863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTGGCTT

<400> 10863
ttggaaaaac tcttctagac                                                   20


<210> 10864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGCTT

<400> 10864
aaatcaattc aagatggata                                                   20


<210> 10865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGATT

<400> 10865
aaatctggag gcatcacctt                                                   20


<210> 10866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TACAGATT

<400> 10866
ccttactgcc aaaagcaata                                                   20


<210> 10867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGATT

<400> 10867
atatacctaa ccaaaaaggt                                                   20


<210> 10868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGTTT

<400> 10868
gatctaataa atgaattcag                                                   20


<210> 10869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGATT

<400> 10869
tgacaaaatc cagcatccca                                                   20


<210> 10870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGATGATT

<400> 10870
gtttcatacc agggaggtag                                                   20


<210> 10871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGGGTTT

<400> 10871
agataacaca ccatgatcaa                                                   20


<210> 10872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTGGATT

<400> 10872
gaaaaaaagt ccaggagcag                                                   20


<210> 10873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCGAGATT

<400> 10873
aaacagacca ataacaagta                                                   20


<210> 10874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTAGATT

<400> 10874
tcctggaaat atacaactgt                                                   20


<210> 10875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCAAGATT

<400> 10875
agaaaattga ttgaccattg                                                   20


<210> 10876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGATT

<400> 10876
ttctttaaaa agatatagaa                                                   20


<210> 10877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGTTT

<400> 10877
gtcaacaatg aaatcaagat                                                   20


<210> 10878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGTTT

<400> 10878
cttcataagt gaagacaaga                                                   20


<210> 10879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTAAGCTT

<400> 10879
gaatattgta tgaagagaaa                                                   20


<210> 10880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGGGATT

<400> 10880
actgaaacct tgcaagccag                                                   20


<210> 10881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCAGATT

<400> 10881
ctgatttaca taagattaac                                                   20


<210> 10882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAAGATT

<400> 10882
ggaaaggtta tctgatttac                                                   20


<210> 10883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGATT

<400> 10883
taacctataa aggaaaggtt                                                   20


<210> 10884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGTTT

<400> 10884
ccaaggaaga atagaaatct                                                   20


<210> 10885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGCTT

<400> 10885
agaacttcag agctcgaaga                                                   20


<210> 10886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGTTT

<400> 10886
gagaaataca aaatgcagtg                                                   20


<210> 10887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGTGATT

<400> 10887
aattcagaag gctgattatt                                                   20


<210> 10888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCTGATT

<400> 10888
aaaaaaaaaa gaattcagaa                                                   20


<210> 10889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGCTT

<400> 10889
tcaggagact gaggcaggag                                                   20


<210> 10890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGGGATT

<400> 10890
tctcaggaag ccccatcccc                                                   20


<210> 10891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGAGCTT

<400> 10891
tttaccctgg ccaacttagg                                                   20


<210> 10892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGCTT

<400> 10892
cacaaaaccc agaaactctc                                                   20


<210> 10893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCATGCTT

<400> 10893
tgagggatgc ggtccaaaag                                                   20


<210> 10894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAAGTTT

<400> 10894
gggaggggtc acaggatgaa                                                   20


<210> 10895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGCTT

<400> 10895
ccttgtaggc actcccagtc                                                   20


<210> 10896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAACGTTT

<400> 10896
agtgtggaga ctcacaccat                                                   20


<210> 10897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTGGATT

<400> 10897
ctgagagatc cttggaactg                                                   20


<210> 10898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAGGATT

<400> 10898
ccttgataaa gatactggca                                                   20


<210> 10899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCATGTTT

<400> 10899
tcaccttggt gatattcttt                                                   20


<210> 10900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGTTT

<400> 10900
tctttttccc tcagtctgtg                                                   20


<210> 10901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGCTT

<400> 10901
tgggagtttt tagatgagcc                                                   20


<210> 10902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGAGTTT

<400> 10902
cactccagtt tctaaaaact                                                   20


<210> 10903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGTTT

<400> 10903
taccactcat cagtctgcac                                                   20


<210> 10904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGCTT

<400> 10904
attccctgct tcagccagtt                                                   20


<210> 10905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCAGTTT

<400> 10905
tctgggtatt ccctgcttca                                                   20


<210> 10906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCTGCTT

<400> 10906
ttggcttgct tctgggtatt                                                   20


<210> 10907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTTGCTT

<400> 10907
gggctctgca gcatagcttg                                                   20


<210> 10908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGCTT

<400> 10908
tctggggctc tgcagcatag                                                   20


<210> 10909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CATAGCTT

<400> 10909
gcagttctgg ggctctgcag                                                   20


<210> 10910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTTGCTT

<400> 10910
acttatcacc ctcccccaaa                                                   20


<210> 10911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AACAGTTT

<400> 10911
caatccattt ctggagcaga                                                   20


<210> 10912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AACTGTTT

<400> 10912
atatgcattt ttcagtatgc                                                   20


<210> 10913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTTGTTT

<400> 10913
cagaagtgaa tagggagggg                                                   20


<210> 10914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCAGATT

<400> 10914
agcatcttca tgggctctaa                                                   20


<210> 10915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGTTT

<400> 10915
tttttcagtt gtttggttgc                                                   20


<210> 10916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTTGCTT

<400> 10916
tttttttttt tcagttgttt                                                   20


<210> 10917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTTGTTT

<400> 10917
ttcttttttt tttttttttc                                                   20


<210> 10918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TACAGTTT

<400> 10918
gagccacagc gcctggccaa                                                   20


<210> 10919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGCGATT

<400> 10919
cgcctcggcc tcccaaagtg                                                   20


<210> 10920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CGGGGTTT

<400> 10920
ttttgtattt ttagtagaga                                                   20


<210> 10921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTTGTTT

<400> 10921
gttgttgttg ctgttgttgt                                                   20


<210> 10922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 10922
acaggttttt ttttttttgt                                                   20


<210> 10923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 10923
attagtacag gttttttttt                                                   20


<210> 10924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAGGTTT

<400> 10924
aactctctaa aaatattagt                                                   20


<210> 10925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 10925
ttttactttt gctatcatat                                                   20


<210> 10926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGTGTTT

<400> 10926
ttatttacaa gtccgcctat                                                   20


<210> 10927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGAGATT

<400> 10927
gcttttttgt tccacttcct                                                   20


<210> 10928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGCTT

<400> 10928
ttttatcact tcctatccat                                                   20


<210> 10929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGATT

<400> 10929
gtcaaacaat atacctccta                                                   20


<210> 10930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GACAGTTT

<400> 10930
tcatatattc taccttcttt                                                   20


<210> 10931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCAGCTT

<400> 10931
tacaggtaca taccaccatg                                                   20


<210> 10932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGTTT

<400> 10932
ccctggatcg catatatgtt                                                   20


<210> 10933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATATGTTT

<400> 10933
gcctcttccc tggatcgcat                                                   20


<210> 10934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGATT

<400> 10934
tttttcttct tcattctttt                                                   20


<210> 10935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGAGATT

<400> 10935
cctgatgcac agctgttttc                                                   20


<210> 10936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGTTT

<400> 10936
gttttctagg cctgatgcac                                                   20


<210> 10937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGATGTTT

<400> 10937
cttctgcctc attctgacct                                                   20


<210> 10938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTTGCTT

<400> 10938
ctcttctcca gatgtttaat                                                   20


<210> 10939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGATGTTT

<400> 10939
ttgttcccaa actcttctcc                                                   20


<210> 10940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGTTT

<400> 10940
ggattttatt tttttgtttg                                                   20


<210> 10941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 10941
agttaataag gattttattt                                                   20


<210> 10942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAGGATT

<400> 10942
tttgctttcc ttggagttaa                                                   20


<210> 10943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGCTT

<400> 10943
atttcctttt tgcacaatgt                                                   20


<210> 10944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAATGTTT

<400> 10944
gactatattt cctttttgca                                                   20


<210> 10945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGTTT

<400> 10945
acattacatt gctaagtaaa                                                   20


<210> 10946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTGGCTT

<400> 10946
ttcaatttct gatgttattt                                                   20


<210> 10947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGCTT

<400> 10947
tctttccaga ggccaccact                                                   20


<210> 10948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGATT

<400> 10948
taaaaggtca cagagtttta                                                   20


<210> 10949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGTTT

<400> 10949
gttcataatt taaaaggtca                                                   20


<210> 10950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACACGATT

<400> 10950
agattcctaa atgatttcaa                                                   20


<210> 10951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGATT

<400> 10951
gcaaccagat atagattcct                                                   20


<210> 10952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TATAGATT

<400> 10952
caagcagcta tgcaaccaga                                                   20


<210> 10953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAAGATT

<400> 10953
caacaaccta taattctgag                                                   20


<210> 10954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGCTT

<400> 10954
gacaaaccag aaatatccat                                                   20


<210> 10955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTTGATT

<400> 10955
tccataattt ctgggtctgt                                                   20


<210> 10956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGTTT

<400> 10956
tctctccata atttctgggt                                                   20


<210> 10957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGGGCTT

<400> 10957
agcacttagg aaataacaca                                                   20


<210> 10958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAATGATT

<400> 10958
cttgactttt tcccaatacc                                                   20


<210> 10959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCGGGATT

<400> 10959
ttgttttcag agcctgaata                                                   20


<210> 10960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGTTT

<400> 10960
agaatttgaa tattatgaat                                                   20


<210> 10961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGTTT

<400> 10961
agttttaaaa ataaggaatg                                                   20


<210> 10962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGTTT

<400> 10962
gcaaatggga agggcttaca                                                   20


<210> 10963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGGGCTT

<400> 10963
tgctttggct ggcaaatggg                                                   20


<210> 10964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGCTT

<400> 10964
gaggctgctc tcccacactg                                                   20


<210> 10965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AACTGATT

<400> 10965
cagtggaaat tgtgaataca                                                   20


<210> 10966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGATT

<400> 10966
gtctgtaata tgcctccaga                                                   20


<210> 10967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGATT

<400> 10967
ctgggggtct gtaatatgcc                                                   20


<210> 10968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGTTT

<400> 10968
atttctgttc gggattataa                                                   20


<210> 10969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCGGGATT

<400> 10969
tttaatgggt acatttctgt                                                   20


<210> 10970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCATGATT

<400> 10970
aacgcaaaag aacaaatgtt                                                   20


<210> 10971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGATT

<400> 10971
tcattcagtt ttaaaaatga                                                   20


<210> 10972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGTTT

<400> 10972
atgtaaacaa ttgaatatca                                                   20


<210> 10973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAATGTTT

<400> 10973
aggtatgttg gcttatgcac                                                   20


<210> 10974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTGGCTT

<400> 10974
aaacagactt taaaaggtat                                                   20


<210> 10975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTAGTTT

<400> 10975
gctctctggt ttaattaaaa                                                   20


<210> 10976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGTTT

<400> 10976
taattttaaa agaagagctc                                                   20


<210> 10977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCAGTTT

<400> 10977
tcctgctggt aagatacaaa                                                   20


<210> 10978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAGGCTT

<400> 10978
tctctactac aagcacaaaa                                                   20


<210> 10979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGTTT

<400> 10979
acttccatat tattttccaa                                                   20


<210> 10980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAACGTTT

<400> 10980
gtacccaatt tattatctgc                                                   20


<210> 10981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGTTT

<400> 10981
tgtaaaaata caaagcatga                                                   20


<210> 10982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTGGTTT

<400> 10982
aaaagagtca tcacttcgaa                                                   20


<210> 10983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTCGCTT

<400> 10983
cttgcatttg ccattattac                                                   20


<210> 10984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCAGTTT

<400> 10984
ttaacatgga gttaatcata                                                   20


<210> 10985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AACTGATT

<400> 10985
aacagtgtat gtgcttcaaa                                                   20


<210> 10986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGCTT

<400> 10986
tatgttttca aaaacagtgt                                                   20


<210> 10987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGTTT

<400> 10987
ttcatagaat ttctaacttt                                                   20


<210> 10988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTAAGATT

<400> 10988
ataattttaa aatctaacat                                                   20


<210> 10989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAATGTTT

<400> 10989
tcatctctct ccatctccta                                                   20


<210> 10990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGTTT

<400> 10990
ggaactccaa cttattctta                                                   20


<210> 10991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTGGATT

<400> 10991
tggttccagc tgatcatttt                                                   20


<210> 10992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAGGTTT

<400> 10992
tatagtaaat ctgtaaacta                                                   20


<210> 10993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTGGCTT

<400> 10993
gactttcatc atgaatgggt                                                   20


<210> 10994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGTTT

<400> 10994
ttatatcaat tttttccatt                                                   20


<210> 10995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGTTT

<400> 10995
cttctaatgt ttcactatta                                                   20


<210> 10996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAATGTTT

<400> 10996
gattttaaag tgtgtgcttc                                                   20


<210> 10997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGTGCTT

<400> 10997
tttgctcttg attttaaagt                                                   20


<210> 10998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGATT

<400> 10998
agtgagcata tttattttgc                                                   20


<210> 10999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGATT

<400> 10999
tgacaaactt gtttcttcct                                                   20


<210> 11000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTTGTTT

<400> 11000
ttatctgcaa ataatgacaa                                                   20


<210> 11001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTAGATT

<400> 11001
tccttaaagt taaatttttc                                                   20


<210> 11002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGTGATT

<400> 11002
taatattatt aatttctata                                                   20


<210> 11003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGATT

<400> 11003
ctttgtttgg taatgcactg                                                   20


<210> 11004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGTTT

<400> 11004
ttcttacaac tctgtggaaa                                                   20


<210> 11005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCAGTTT

<400> 11005
ttgtttcttt acttttccat                                                   20


<210> 11006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGTTT

<400> 11006
ttcttgaaaa ttattttggt                                                   20


<210> 11007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTCGATT

<400> 11007
tctatagtaa gatttgacct                                                   20


<210> 11008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTAAGATT

<400> 11008
gtggatttaa atgctctata                                                   20


<210> 11009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CGTGGATT

<400> 11009
cacatcctga gtcaacacca                                                   20


<210> 11010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGTTT

<400> 11010
cagattccca tgtctactga                                                   20


<210> 11011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCAGATT

<400> 11011
taccactgct tctgccatgc                                                   20


<210> 11012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGCTT

<400> 11012
atttcccaag tggttcctac                                                   20


<210> 11013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TATGGATT

<400> 11013
aggcttccaa tatttttcca                                                   20


<210> 11014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAGGCTT

<400> 11014
ttgtatgtgt gtggtatgag                                                   20


<210> 11015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TACAGTTT

<400> 11015
ctgtgttttc tcctcaaagt                                                   20


<210> 11016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGTTT

<400> 11016
tattccataa agatattatc                                                   20


<210> 11017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGGGATT

<400> 11017
gatgttttaa aattatgttt                                                   20


<210> 11018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGTTT

<400> 11018
ctttatctga tgttttaaaa                                                   20


<210> 11019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGTTT

<400> 11019
ttttatatgt gtgctttatc                                                   20


<210> 11020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGTGCTT

<400> 11020
gaactgttat cattttatat                                                   20


<210> 11021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TATTGATT

<400> 11021
ttaacactgc atgcataaag                                                   20


<210> 11022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGTGTTT

<400> 11022
tctactgcaa acggggaagt                                                   20


<210> 11023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGTTT

<400> 11023
aatttggttg tagagaagat                                                   20


<210> 11024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTGGTTT

<400> 11024
ctttcctact ctccccatgc                                                   20


<210> 11025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGATT

<400> 11025
gaagaaacta gaggttcttc                                                   20


<210> 11026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGCTT

<400> 11026
ttccattttc taatcccctc                                                   20


<210> 11027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGCTT

<400> 11027
ttctgcgtgc ctgcctatct                                                   20


<210> 11028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTAGCTT

<400> 11028
ccattattcc ttgctgaaac                                                   20


<210> 11029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTTGTTT

<400> 11029
gcaaattgat aatagccatt                                                   20


<210> 11030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTAGATT

<400> 11030
ggcctcgtgg aaataatcag                                                   20


<210> 11031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGATT

<400> 11031
aattatcaaa tccattcttt                                                   20


<210> 11032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAAGTTT

<400> 11032
tttcatttgc atggatgaag                                                   20


<210> 11033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AACAGATT

<400> 11033
tgttttatag aaattagctg                                                   20


<210> 11034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGTTT

<400> 11034
cccaaaaaaa tcccagcagc                                                   20


<210> 11035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAAGATT

<400> 11035
atgtctcatg tgactggatt                                                   20


<210> 11036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTGGATT

<400> 11036
attaaaggat gtctcatgtg                                                   20


<210> 11037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AACAGTTT

<400> 11037
cgagggaagg aaagataaaa                                                   20


<210> 11038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGATT

<400> 11038
taatataatt aatataatgt                                                   20


<210> 11039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCATGATT

<400> 11039
gcaaacaaag aaagcaggat                                                   20


<210> 11040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATGGATT

<400> 11040
ctgtcatgtc actaaatata                                                   20


<210> 11041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGCTT

<400> 11041
caaataagaa aatcgctcga                                                   20


<210> 11042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGCTT

<400> 11042
tgttgatgtt gagttgtctc                                                   20


<210> 11043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CGATGATT

<400> 11043
agttgtaaga ggatcaactt                                                   20


<210> 11044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGCTT

<400> 11044
tggtcaacga tgagttcttc                                                   20


<210> 11045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGCTT

<400> 11045
ggagctgttt cacctttcca                                                   20


<210> 11046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGTTT

<400> 11046
tatgaggcac ccatttatgg                                                   20


<210> 11047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTAGCTT

<400> 11047
cgatttttta aacatttttc                                                   20


<210> 11048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGACGATT

<400> 11048
gagacgacaa cacttcaaaa                                                   20


<210> 11049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGATT

<400> 11049
actttttatc gcacatcaca                                                   20


<210> 11050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGAGCTT

<400> 11050
ttgggttttg ggaagtgctt                                                   20


<210> 11051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGTGCTT

<400> 11051
ggtgcaagtt gggttttggg                                                   20


<210> 11052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGGGTTT

<400> 11052
acgacttttt ttggtgcaag                                                   20


<210> 11053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGATT

<400> 11053
tctcagatgt aatggctttg                                                   20


<210> 11054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATGGCTT

<400> 11054
tgaacatatt tctcagatgt                                                   20


<210> 11055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CATCGATT

<400> 11055
ttgcagtttt ctgtgcatct                                                   20


<210> 11056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGTTT

<400> 11056
ccaatgccag ctgcaggcct                                                   20


<210> 11057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGATGCTT

<400> 11057
tcacctgcaa aaagttgttc                                                   20


<210> 11058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGTGTTT

<400> 11058
ctgcatcccg ctggttatgg                                                   20


<210> 11059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGGGATT

<400> 11059
gtagcataaa aatccatgct                                                   20


<210> 11060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCATGCTT

<400> 11060
tattcctgta gcataaaaat                                                   20


<210> 11061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTTGTTT

<400> 11061
tttttgccaa tgagaaatga                                                   20


<210> 11062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGTTT

<400> 11062
cacatttttg ccaatgagaa                                                   20


<210> 11063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGGGTTT

<400> 11063
tgaaaaggta caaaagtaat                                                   20


<210> 11064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAAGTTT

<400> 11064
attataatta taaatttata                                                   20


<210> 11065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CACGGTTT

<400> 11065
acactaagga caatgtatta                                                   20


<210> 11066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGATT

<400> 11066
caccaaatgg aaatgagaga                                                   20


<210> 11067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGATT

<400> 11067
aggaatcacc aaatggaaat                                                   20


<210> 11068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGCTT

<400> 11068
agcagagtat gttcacttac                                                   20


<210> 11069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGGGTTT

<400> 11069
tggtaaatca cttagcagat                                                   20


<210> 11070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATATGTTT

<400> 11070
aaatatggaa gatagaatgc                                                   20


<210> 11071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGAGATT

<400> 11071
tgagttattt gggagttatt                                                   20


<210> 11072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGAGTTT

<400> 11072
taaaatgtct atgcttcttt                                                   20


<210> 11073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTATGCTT

<400> 11073
tcatatagca tgtaaaatgt                                                   20


<210> 11074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGTTT

<400> 11074
tttgttttaa aataattaat                                                   20


<210> 11075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGTTT

<400> 11075
aggctgacta atacacaaac                                                   20


<210> 11076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGATT

<400> 11076
cccaatctca ggcttcaacc                                                   20


<210> 11077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAGGCTT

<400> 11077
actatgctga catcccaatc                                                   20


<210> 11078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GACAGCTT

<400> 11078
gtgtccttat aagagaaaga                                                   20


<210> 11079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGTGATT

<400> 11079
tggagattgg gcctctaagg                                                   20


<210> 11080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGAGATT

<400> 11080
aaccccccat gttgctatgt                                                   20


<210> 11081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 11081
aatcaagcaa aactaaacta                                                   20


<210> 11082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGTTT

<400> 11082
ataaacaagg ttcatttata                                                   20


<210> 11083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGATT

<400> 11083
gaacaaaaaa agccaaatgc                                                   20


<210> 11084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGTTT

<400> 11084
acaccagatt acagctacaa                                                   20


<210> 11085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCAGATT

<400> 11085
agaaatatgt acttgtggac                                                   20


<210> 11086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTATGTTT

<400> 11086
tctattacac ccttaggtac                                                   20


<210> 11087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGATT

<400> 11087
agttgcaaat taaaatcaca                                                   20


<210> 11088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGTGCTT

<400> 11088
ctttaagagc atgaaaaagc                                                   20


<210> 11089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAAGCTT

<400> 11089
agccgacttg atcgtggtgg                                                   20


<210> 11090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCAGCTT

<400> 11090
tattgacttg cgtatgttga                                                   20


<210> 11091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTACGTTT

<400> 11091
ggttctgttt gtgtgatgga                                                   20


<210> 11092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGATT

<400> 11092
gtcattggtt ctgtttgtgt                                                   20


<210> 11093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGTTT

<400> 11093
cacgtggttt ttgtcattgg                                                   20


<210> 11094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CGTGGTTT

<400> 11094
tgcatctatt gagataatca                                                   20


<210> 11095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGCTT

<400> 11095
ccatcaatac ctagtttatt                                                   20


<210> 11096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTAGTTT

<400> 11096
tgagatacat tccatcaata                                                   20


<210> 11097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGGGCTT

<400> 11097
cattcagtat gatattggct                                                   20


<210> 11098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGTTT

<400> 11098
tggttttcaa aggaaatgct                                                   20


<210> 11099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGCTT

<400> 11099
cttgtgctgg ttttcaaagg                                                   20


<210> 11100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTGGTTT

<400> 11100
atagggcatt cttgtcttgt                                                   20


<210> 11101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGGGTTT

<400> 11101
gagattttgg gctgagatga                                                   20


<210> 11102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGATT

<400> 11102
tgaagttgct tatcagctta                                                   20


<210> 11103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCAGCTT

<400> 11103
agactttgct gaagttgctt                                                   20


<210> 11104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTTGCTT

<400> 11104
gtatcctgag actttgctga                                                   20


<210> 11105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CATTGATT

<400> 11105
gaatgcttgt gatttttgca                                                   20


<210> 11106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGTGATT

<400> 11106
ttattggtgt atgggaatgc                                                   20


<210> 11107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAATGCTT

<400> 11107
tgtctgttat tggtgtatgg                                                   20


<210> 11108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCGGTTT

<400> 11108
agttcactca tgatttggct                                                   20


<210> 11109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCATGATT

<400> 11109
aattgtgaat gggagttcac                                                   20


<210> 11110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGATT

<400> 11110
tcctctctta tttccttgag                                                   20


<210> 11111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAATGTTT

<400> 11111
ttttcctatc catgagcatg                                                   20


<210> 11112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TATTGATT

<400> 11112
cagtatggcc attttcacaa                                                   20


<210> 11113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTAGCTT

<400> 11113
attctgtgaa gaaagtcagt                                                   20


<210> 11114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTAGATT

<400> 11114
ttgttccaca tgaaatttaa                                                   20


<210> 11115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGCTT

<400> 11115
gatgcctcca actttcttct                                                   20


<210> 11116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TATAGCTT

<400> 11116
tggttactgt agctttgtag                                                   20


<210> 11117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTAGCTT

<400> 11117
tacctcgctg ttttggttac                                                   20


<210> 11118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CGCTGTTT

<400> 11118
ctgttttggt accagtacct                                                   20


<210> 11119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGTTT

<400> 11119
tctgttccat tggtctagat                                                   20


<210> 11120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAAGTTT

<400> 11120
ttccccattg cttgcttttg                                                   20


<210> 11121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTTGCTT

<400> 11121
tagggaatcc tttccccatt                                                   20


<210> 11122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CATTGCTT

<400> 11122
taaataggga atcctttccc                                                   20


<210> 11123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCAGTTT

<400> 11123
caattttctg cctaaggcta                                                   20


<210> 11124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGTTT

<400> 11124
tgtaaggtat aaggaaggga                                                   20


<210> 11125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGTTT

<400> 11125
ggtttttatg gttttaggtc                                                   20


<210> 11126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TATGGTTT

<400> 11126
aggttttctt ctagggtttt                                                   20


<210> 11127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGGGTTT

<400> 11127
gtattgccta ggttttcttc                                                   20


<210> 11128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTAGGTTT

<400> 11128
tatgtcctga agggtattgc                                                   20


<210> 11129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CATTGCTT

<400> 11129
tcaattttgg cttttgtcac                                                   20


<210> 11130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGCTT

<400> 11130
attggattcc atttgtcaat                                                   20


<210> 11131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTGGATT

<400> 11131
tgcagaagct ctttagttta                                                   20


<210> 11132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGTTT

<400> 11132
cttttgctgt gcagaagctc                                                   20


<210> 11133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GATAGTTT

<400> 11133
ggttacctat tcactctgat                                                   20


<210> 11134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GATAGATT

<400> 11134
tattagccct ttgtcagatt                                                   20


<210> 11135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCAGATT

<400> 11135
attctggata ttagcccttt                                                   20


<210> 11136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTAGATT

<400> 11136
gtaaatttgt ttaagttttt                                                   20


<210> 11137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAAGTTT

<400> 11137
gttttttctt gtaaatttgt                                                   20


<210> 11138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGTTT

<400> 11138
ggagttgttt tttcttgtaa                                                   20


<210> 11139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTTGTTT

<400> 11139
ctttgcccac tttttgatgg                                                   20


<210> 11140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATATGTTT

<400> 11140
gtgatgatga gctttttatc                                                   20


<210> 11141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGCTT

<400> 11141
ttctctaatg accagtgatg                                                   20


<210> 11142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGTTT

<400> 11142
ggtatgagac tccatctcat                                                   20


<210> 11143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTTGTTT

<400> 11143
tccacatcct ctccagcatc                                                   20


<210> 11144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGTGTTT

<400> 11144
aatggaattg ctgggtcaaa                                                   20


<210> 11145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCATGCTT

<400> 11145
tagtgccaca ataaacatac                                                   20


<210> 11146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGCGTTT

<400> 11146
ttatccagtc tatcactgat                                                   20


<210> 11147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGCTT

<400> 11147
gtttgctgag aatgatggtt                                                   20


<210> 11148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGTTT

<400> 11148
tatgtcagtt tgctgagaat                                                   20


<210> 11149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCAGTTT

<400> 11149
gtttggtttt ctgttcttat                                                   20


<210> 11150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGTTT

<400> 11150
atgagtgaga acatgcggtg                                                   20


<210> 11151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CGGTGTTT

<400> 11151
cacctatgag tgagaacatg                                                   20


<210> 11152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTGGTTT

<400> 11152
cataggtata cacatgtcat                                                   20


<210> 11153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCAGGTTT

<400> 11153
ggggtacatg tgcagaaagt                                                   20


<210> 11154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTTGCTT

<400> 11154
tctaggtgga tcaacacctc                                                   20


<210> 11155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTAAGATT

<400> 11155
tgaagcagtg tgccattggt                                                   20


<210> 11156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCGAGATT

<400> 11156
agaactcatt ctactggatg                                                   20


<210> 11157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGTTT

<400> 11157
aactttaaat tttcttcctc                                                   20


<210> 11158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAGGCTT

<400> 11158
atcctcaaat caatatttca                                                   20


<210> 11159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGATT

<400> 11159
aatattgtaa agactcccaa                                                   20


<210> 11160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGATT

<400> 11160
aatcagtggg gagacatgtt                                                   20


<210> 11161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGTTT

<400> 11161
aaattataat aagtattgtg                                                   20


<210> 11162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAAGATT

<400> 11162
aaaatgtcaa gtatctagga                                                   20


<210> 11163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATAGTTT

<400> 11163
gacactagca acaaacagaa                                                   20


<210> 11164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAAGATT

<400> 11164
gaagatgtaa tttacagata                                                   20


<210> 11165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGCTT

<400> 11165
catacttaat tgtgaacatg                                                   20


<210> 11166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CATTGTTT

<400> 11166
tcactctgat aaagggtatt                                                   20


<210> 11167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGGGATT

<400> 11167
aaagtataat aattttaaaa                                                   20


<210> 11168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGTTT

<400> 11168
ttgatgctaa aatcatttga                                                   20


<210> 11169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATAGATT

<400> 11169
aaatacgtta tatttttatt                                                   20


<210> 11170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGCTT

<400> 11170
ttataataac aggtgctttg                                                   20


<210> 11171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGTGCTT

<400> 11171
atacctttgg ttataataac                                                   20


<210> 11172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGCTT

<400> 11172
tctgggaggg atgcttccac                                                   20


<210> 11173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGATGCTT

<400> 11173
catatccaca catctgggag                                                   20


<210> 11174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGAGTTT

<400> 11174
cccctatagt ttcagaatct                                                   20


<210> 11175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TATAGTTT

<400> 11175
aggttagtgg gtgaaacccc                                                   20


<210> 11176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCATGCTT

<400> 11176
aaatgaagct gtttaagtta                                                   20


<210> 11177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGTTT

<400> 11177
agaaaataac tcataaatga                                                   20


<210> 11178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTATGCTT

<400> 11178
aaatgtatgc cttagagaag                                                   20


<210> 11179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGAGATT

<400> 11179
gctgcatatt gcaatttttg                                                   20


<210> 11180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TACAGATT

<400> 11180
gattttcagt ttcaaagaga                                                   20


<210> 11181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGTTT

<400> 11181
tttcataaac atacatgatt                                                   20


<210> 11182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACATGATT

<400> 11182
gagatttgtt tcataaacat                                                   20


<210> 11183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGTTT

<400> 11183
caggtctctc cttctgtgag                                                   20


<210> 11184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGAGATT

<400> 11184
ataaccaggt ctctccttct                                                   20


<210> 11185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGCTT

<400> 11185
atcattattg taccatctct                                                   20


<210> 11186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTAGATT

<400> 11186
cttccagaga aaattgagtg                                                   20


<210> 11187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGTTT

<400> 11187
aacacaggcc tttcaggtgg                                                   20


<210> 11188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGCTT

<400> 11188
catcacagag acttggtgat                                                   20


<210> 11189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTAAGATT

<400> 11189
gatcataaag ctaatattgg                                                   20


<210> 11190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTAGCTT

<400> 11190
aacatggaca aagtactcag                                                   20


<210> 11191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGCTT

<400> 11191
tattttttgt cagcctgttt                                                   20


<210> 11192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCTGTTT

<400> 11192
ttaactttta ttttttgtca                                                   20


<210> 11193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGTTT

<400> 11193
ctgtttcctt ctatcttgct                                                   20


<210> 11194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGTTT

<400> 11194
aggacatttt ggaaaaggga                                                   20


<210> 11195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAGGCTT

<400> 11195
gccattttgt atactgaaat                                                   20


<210> 11196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAAGTTT

<400> 11196
ttgtacctct tcacttatct                                                   20


<210> 11197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGTTT

<400> 11197
ctgatgaaac taattcccat                                                   20


<210> 11198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGGGTTT

<400> 11198
cactccagcc taatcctact                                                   20


<210> 11199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGATT

<400> 11199
ccaagtggga acaatttacc                                                   20


<210> 11200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAAGTTT

<400> 11200
tctgtaggtc aagtttatct                                                   20


<210> 11201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAAGTTT

<400> 11201
tgttgtactc tctctgtagg                                                   20


<210> 11202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGTTT

<400> 11202
attgtaagtc agcaggaaaa                                                   20


<210> 11203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGATT

<400> 11203
gacacgattt tagtttaatc                                                   20


<210> 11204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGTTT

<400> 11204
tgtagaattg gagacacgat                                                   20


<210> 11205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACACGATT

<400> 11205
aaatatttgt agaattggag                                                   20


<210> 11206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAATGTTT

<400> 11206
attctaatca catttgctat                                                   20


<210> 11207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGCTT

<400> 11207
ttgagatttg atgagtaaat                                                   20


<210> 11208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGAGATT

<400> 11208
cagtgaatat tctcttcatc                                                   20


<210> 11209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TATGGATT

<400> 11209
caaacataca aactcctctt                                                   20


<210> 11210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTTGCTT

<400> 11210
gtcgtctctg cttgggtagt                                                   20


<210> 11211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGCTT

<400> 11211
ttattctctc aatgtgtcgt                                                   20


<210> 11212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGAGATT

<400> 11212
cagttcaaaa gcctctgaag                                                   20


<210> 11213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGATT

<400> 11213
tctgagctga atcttgaatt                                                   20


<210> 11214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTACGTTT

<400> 11214
ttctggctgg ccagcaagaa                                                   20


<210> 11215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTACGTTT

<400> 11215
cacagcttga tgaagttgca                                                   20


<210> 11216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CACAGCTT

<400> 11216
gcacactcaa catgaagctg                                                   20


<210> 11217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTGGATT

<400> 11217
ccctaactct gaggcagatt                                                   20


<210> 11218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCAGATT

<400> 11218
accctgctcc ctaactctga                                                   20


<210> 11219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAGGCTT

<400> 11219
tggtaaccag ccttttctta                                                   20


<210> 11220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTGGCTT

<400> 11220
ttctttatga caaatttagc                                                   20


<210> 11221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAGGATT

<400> 11221
cctaagatcc ttggtcatcg                                                   20


<210> 11222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGTTT

<400> 11222
gtagaaaaaa gatactttgg                                                   20


<210> 11223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGTTT

<400> 11223
aactagtaga aaaaagatac                                                   20


<210> 11224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGGGATT

<400> 11224
taatgtcaga agctgctttc                                                   20


<210> 11225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGCTT

<400> 11225
ttgttttagg taatgtcaga                                                   20


<210> 11226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGTTT

<400> 11226
ggtcaaatgt ctactatatg                                                   20


<210> 11227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAATGATT

<400> 11227
gttcatgcca tacaagactg                                                   20


<210> 11228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCAGGTTT

<400> 11228
aaattactca aaaactacta                                                   20


<210> 11229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCTGCTT

<400> 11229
ccatagccat gctgagaagt                                                   20


<210> 11230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCCGCTT

<400> 11230
cattctcacc acggtgtgtg                                                   20


<210> 11231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAGGTTT

<400> 11231
aaaacatcct ctttatgagg                                                   20


<210> 11232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGATT

<400> 11232
tttatgcaac acacaggtgg                                                   20


<210> 11233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTGGTTT

<400> 11233
aagtgtttat gcaacacaca                                                   20


<210> 11234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGTGTTT

<400> 11234
gcagtcccaa gacacagaag                                                   20


<210> 11235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATGGCTT

<400> 11235
tgaggtcatt agattgaaaa                                                   20


<210> 11236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTAGATT

<400> 11236
cccaaaagta caatgaggtc                                                   20


<210> 11237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCACGATT

<400> 11237
tctgtccact catatccttt                                                   20


<210> 11238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCGGTTT

<400> 11238
gaacaaaggg aggaccattt                                                   20


<210> 11239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 11239
gaggtccact ttctgttttg                                                   20


<210> 11240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 11240
cattggaggt ccactttctg                                                   20


<210> 11241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGTTT

<400> 11241
tttctcattg gaggtccact                                                   20


<210> 11242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGTTT

<400> 11242
aaacatggtt gtataaggaa                                                   20


<210> 11243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCATGTTT

<400> 11243
taagcctgag ataatgcctc                                                   20


<210> 11244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TATGGCTT

<400> 11244
tcttgctgag agggtgagga                                                   20


<210> 11245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAGGATT

<400> 11245
cataacacct cttaccagcc                                                   20


<210> 11246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAGGATT

<400> 11246
cctcagaggg agaaaccagg                                                   20


<210> 11247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCATGTTT

<400> 11247
cgagccaaaa aatggtgaat                                                   20


<210> 11248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGCTT

<400> 11248
tgagaatcag tagtttaaac                                                   20


<210> 11249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTAGTTT

<400> 11249
aatcaaaaag tttgagaatc                                                   20


<210> 11250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGTTT

<400> 11250
agtaataatc cctgaaatca                                                   20


<210> 11251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAGGTTT

<400> 11251
aagttatttg gggtcctcaa                                                   20


<210> 11252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGTTT

<400> 11252
ttcccgtgtt ttaaaatttc                                                   20


<210> 11253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCGTGTTT

<400> 11253
gaatgtgtgc ctgtatattc                                                   20


<210> 11254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGGGTTT

<400> 11254
gtgtccccaa aactgtttta                                                   20


<210> 11255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AACTGTTT

<400> 11255
ggaacccctg gtgtccccaa                                                   20


<210> 11256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGCTT

<400> 11256
tcaaaagcag ataactgctg                                                   20


<210> 11257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGATT

<400> 11257
tgggtgatgt ggcagtctgc                                                   20


<210> 11258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CGTCGCTT

<400> 11258
ccctcgaaac taacaacttc                                                   20


<210> 11259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGATT

<400> 11259
tgttgacaat gtcaataaat                                                   20


<210> 11260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGGGATT

<400> 11260
tgttctagat tgacttagcc                                                   20


<210> 11261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGATT

<400> 11261
cagcagttca ggggaactgt                                                   20


<210> 11262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATATGATT

<400> 11262
aactgctgac tagggatacc                                                   20


<210> 11263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTGGCTT

<400> 11263
atgaactagg aaatatggtc                                                   20


<210> 11264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGTTT

<400> 11264
atggtatgaa gttggcagag                                                   20


<210> 11265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAGGTTT

<400> 11265
gctgcagaca caggtgagtt                                                   20


<210> 11266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGTTT

<400> 11266
ggatgggctc tgcatcaagg                                                   20


<210> 11267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAAGCTT

<400> 11267
gtgagatagg agggcaaaat                                                   20


<210> 11268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGATT

<400> 11268
gagacagagg ttgcagtgag                                                   20


<210> 11269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGCTT

<400> 11269
tcgggaggct gaggtgggag                                                   20


<210> 11270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGCTT

<400> 11270
ttaatgtaat aatgcatgaa                                                   20


<210> 11271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGTTT

<400> 11271
agagattgtg gcaaacatac                                                   20


<210> 11272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGATT

<400> 11272
gggaatgatg agatgtttcc                                                   20


<210> 11273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGATGTTT

<400> 11273
gtgaagatat gggaatgatg                                                   20


<210> 11274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGCTT

<400> 11274
tgagtttagt ttggggcatg                                                   20


<210> 11275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGTTT

<400> 11275
agtgaggaga taattatgag                                                   20


<210> 11276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGTTT

<400> 11276
aaagaagtga ggagataatt                                                   20


<210> 11277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTTGATT

<400> 11277
cagaagcaac agcactagat                                                   20


<210> 11278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGATGTTT

<400> 11278
gaggcagaag caacagcact                                                   20


<210> 11279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGATT

<400> 11279
atacgaggcc agtgagatga                                                   20


<210> 11280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCAGATT

<400> 11280
ttaaataaag atatcacata                                                   20


<210> 11281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAATGATT

<400> 11281
gagtgctatg gagagcttta                                                   20


<210> 11282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGCTT

<400> 11282
gggttatctt gagtgctatg                                                   20


<210> 11283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CACAGTTT

<400> 11283
ccatgctgga gaggtcagcg                                                   20


<210> 11284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAGGATT

<400> 11284
gccaagagta caagaataag                                                   20


<210> 11285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AGATGTTT

<400> 11285
gcaaacagaa attacaaatc                                                   20


<210> 11286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGCTT

<400> 11286
agatgtgagt ccagctctca                                                   20


<210> 11287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAAGTTT

<400> 11287
gttctttagt ttttcagcta                                                   20


<210> 11288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGTTT

<400> 11288
tttttctgaa caaaatgttc                                                   20


<210> 11289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGATT

<400> 11289
ttatattcct attattggat                                                   20


<210> 11290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGAGCTT

<400> 11290
tctgcttgac tttggggtgt                                                   20


<210> 11291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGCTT

<400> 11291
taagcactgc ctctgccacc                                                   20


<210> 11292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGATT

<400> 11292
aggatctcca tcataggggt                                                   20


<210> 11293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTGGATT

<400> 11293
agtgtctata tcacagaggt                                                   20


<210> 11294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGTTT

<400> 11294
attaaagaca ctgaagtcaa                                                   20


<210> 11295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGTTT

<400> 11295
gaagagaaag ttaacttaat                                                   20


<210> 11296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGATT

<400> 11296
tgttactaaa caactgagtc                                                   20


<210> 11297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGCTT

<400> 11297
ccagctccag gacctggaat                                                   20


<210> 11298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGCTT

<400> 11298
gaagtcagtc tcatagctga                                                   20


<210> 11299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGGGATT

<400> 11299
aacaattttg tccttagctg                                                   20


<210> 11300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AATAGTTT

<400> 11300
agataaacta cttgcacccc                                                   20


<210> 11301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TACTGCTT

<400> 11301
gagtaaatgg ctcataaaaa                                                   20


<210> 11302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCAGTTT

<400> 11302
ctcagtgaaa caattctgag                                                   20


<210> 11303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGGGCTT

<400> 11303
acttcctgcc tctgtctgcc                                                   20


<210> 11304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGGGATT

<400> 11304
cattcaacta gactctaaaa                                                   20


<210> 11305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGCTT

<400> 11305
atatggctac ctcacaaagg                                                   20


<210> 11306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGATT

<400> 11306
ctaaactaga atagatattt                                                   20


<210> 11307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CCGAGCTT

<400> 11307
agactgtttg aaagccaggg                                                   20


<210> 11308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GACTGTTT

<400> 11308
tacctgcaaa aactcatgca                                                   20


<210> 11309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTTGCTT

<400> 11309
aatgcccacc gaatagaaag                                                   20


<210> 11310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGCTT

<400> 11310
gctgaatgcc caccgaatag                                                   20


<210> 11311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGATT

<400> 11311
gaggtcaagg ctgcaatgag                                                   20


<210> 11312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAAGATT

<400> 11312
gaaaaacccc atcaaaaata                                                   20


<210> 11313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAGGTTT

<400> 11313
tttgtaccct tttggtaacc                                                   20


<210> 11314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGCTT

<400> 11314
tttggtaacc ttaggttttg                                                   20


<210> 11315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 11315
ttaatgtaat ttatgaatat                                                   20


<210> 11316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGTTT

<400> 11316
tactttactc tgtcttttct                                                   20


<210> 11317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCGGGTTT

<400> 11317
attctgtatg tctctatatc                                                   20


<210> 11318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAAGTTT

<400> 11318
tttttaatta ttattatact                                                   20


<210> 11319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCAGGTTT

<400> 11319
aggatacatg agcacaacgt                                                   20


<210> 11320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CGGTGTTT

<400> 11320
cacctatgag tgagaacatg                                                   20


<210> 11321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGTTT

<400> 11321
atgagtgaga acatgcggtg                                                   20


<210> 11322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATAGTTT

<400> 11322
ttggtttttt ttgtccttgc                                                   20


<210> 11323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGTTT

<400> 11323
tgcgatagtt tgctgagaat                                                   20


<210> 11324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGCTT

<400> 11324
gtttgctgag aatgatggtt                                                   20


<210> 11325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTATGATT

<400> 11325
gtgcatgtgt ctttatagca                                                   20


<210> 11326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAATGATT

<400> 11326
aattgccaca ccgacttcca                                                   20


<210> 11327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTAGTTT

<400> 11327
ccgacttcca caatgattga                                                   20


<210> 11328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTTGTTT

<400> 11328
tccacatcct ctccagcacc                                                   20


<210> 11329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGTTT

<400> 11329
ggtgtgagat ggtatctcat                                                   20


<210> 11330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGATT

<400> 11330
gagatggtat ctcattgtgg                                                   20


<210> 11331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGTTT

<400> 11331
gtgatgatga gcattttttc                                                   20


<210> 11332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGGGATT

<400> 11332
tatccttcgc ccactttttg                                                   20


<210> 11333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGTTT

<400> 11333
tgggattttt ttccttgtaa                                                   20


<210> 11334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTAGATT

<400> 11334
gtaaatttgt ttgagttcat                                                   20


<210> 11335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTAGGTTT

<400> 11335
caaaaatttt ctcccatcct                                                   20


<210> 11336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTGGTTT

<400> 11336
aggtttctgt tcactctgat                                                   20


<210> 11337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGTTT

<400> 11337
cttttgctgc tcagaagctc                                                   20


<210> 11338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CATTGCTT

<400> 11338
tcaattttga cttttgttgc                                                   20


<210> 11339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGTGTTT

<400> 11339
acttttgttg ccattgcttt                                                   20


<210> 11340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGGGTTT

<400> 11340
gtattgccta ggttctcttc                                                   20


<210> 11341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATGGTTT

<400> 11341
aggttctctt ctagggtttt                                                   20


<210> 11342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGTTT

<400> 11342
tataaggtgt aaggaaggga                                                   20


<210> 11343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGCTT

<400> 11343
gtgtaaggaa gggatccagt                                                   20


<210> 11344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCAGTTT

<400> 11344
cagctttctc catatggcta                                                   20


<210> 11345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGTTT

<400> 11345
tagggaatcc tttccccatt                                                   20


<210> 11346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAGGTTT

<400> 11346
ttccccattt cttgtttttg                                                   20


<210> 11347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGTTT

<400> 11347
tctgttccat tggtctatat                                                   20


<210> 11348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGTTT

<400> 11348
ctgttttggt accagtacca                                                   20


<210> 11349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATAGTTT

<400> 11349
tggttactgt agccttgtaa                                                   20


<210> 11350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGCTT

<400> 11350
aagtcaggta gcgtgatgcc                                                   20


<210> 11351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGCTT

<400> 11351
atgagtgaac tcccattcac                                                   20


<210> 11352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATAGATT

<400> 11352
ccatactgcc caaggtaatt                                                   20


<210> 11353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCTGTTT

<400> 11353
cattgccaag tcaatcctaa                                                   20


<210> 11354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGATT

<400> 11354
tttttttttt aaccttactt                                                   20


<210> 11355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGTTT

<400> 11355
ccttactttt ttgattggct                                                   20


<210> 11356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGATT

<400> 11356
ttggaaatga tatactctat                                                   20


<210> 11357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGTTT

<400> 11357
ccatctgtgt ctatgtgtta                                                   20


<210> 11358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CGGTGTTT

<400> 11358
aatggtataa aaagttaggg                                                   20


<210> 11359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGATT

<400> 11359
tatcctcaca ttctgggcca                                                   20


<210> 11360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGTTT

<400> 11360
acattctggg ccagagagat                                                   20


<210> 11361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGTTT

<400> 11361
caggttggct cccatggaaa                                                   20


<210> 11362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAATGTTT

<400> 11362
tgtatattgc atcccttttc                                                   20


<210> 11363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATGGATT

<400> 11363
tttgtgcaga aaaaatgaga                                                   20


<210> 11364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTAGTTT

<400> 11364
gcagaaaaaa tgagaaatgg                                                   20


<210> 11365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTAGCTT

<400> 11365
cgttgccttc catgtctcct                                                   20


<210> 11366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCCGATT

<400> 11366
cttggcctgc acatgtatct                                                   20


<210> 11367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGTGTTT

<400> 11367
tacagctgtc ttttctttgt                                                   20


<210> 11368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTGGATT

<400> 11368
atattttagc aacaccagtc                                                   20


<210> 11369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGTTT

<400> 11369
tagggctcac cttcatctga                                                   20


<210> 11370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTATGTTT

<400> 11370
cataaagttg aattatgttc                                                   20


<210> 11371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGCTT

<400> 11371
atacttttga gaatagtatc                                                   20


<210> 11372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGTTT

<400> 11372
tgctttaata gaaccagtct                                                   20


<210> 11373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGCTT

<400> 11373
acacttgggc tagtatctca                                                   20


<210> 11374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGGGATT

<400> 11374
atggcttttt catcatccac                                                   20


<210> 11375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGATT

<400> 11375
aaatcaggca ttcagagaat                                                   20


<210> 11376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGCTT

<400> 11376
tcagagaata gctgatttga                                                   20


<210> 11377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGCTT

<400> 11377
catgtgagat gtatcagcca                                                   20


<210> 11378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGTGATT

<400> 11378
ttggctatat atttgaatct                                                   20


<210> 11379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGCTT

<400> 11379
cctatgttgt tatagggagt                                                   20


<210> 11380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGGGCTT

<400> 11380
gttcatacaa ttaatctttt                                                   20


<210> 11381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCATGATT

<400> 11381
tatctactgg atcatcattc                                                   20


<210> 11382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGATT

<400> 11382
tctcatgatt atactttttc                                                   20


<210> 11383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGATT

<400> 11383
taaaaactct cctccttaat                                                   20


<210> 11384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGTGCTT

<400> 11384
gccatttcag cctcagaaaa                                                   20


<210> 11385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAGGATT

<400> 11385
ccagacaatt ggtggaaaag                                                   20


<210> 11386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGCTT

<400> 11386
gaaataagag aaaaataaaa                                                   20


<210> 11387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGCTT

<400> 11387
ttaattttaa tggatatctc                                                   20


<210> 11388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAAGTTT

<400> 11388
ctttggaagt tctggtcctg                                                   20


<210> 11389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGATT

<400> 11389
agtttgtctc agtaaatata                                                   20


<210> 11390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTAGCTT

<400> 11390
gaaatcacag tggaagtgct                                                   20


<210> 11391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGTTT

<400> 11391
tctgactcct atttgtgtat                                                   20


<210> 11392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTGGCTT

<400> 11392
ggggcaatca gctccatact                                                   20


<210> 11393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCAGTTT

<400> 11393
ggtgggaatg atgtggcaga                                                   20


<210> 11394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGATT

<400> 11394
aatgatgtgg cagaagcagt                                                   20


<210> 11395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGCTT

<400> 11395
tgacagtggc tgaaatgtct                                                   20


<210> 11396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGATGATT

<400> 11396
gtggttgcta ttggttcata                                                   20


<210> 11397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGATT

<400> 11397
ttggttcata ggatgatttt                                                   20


<210> 11398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCGGATT

<400> 11398
gccttcagag aatccaactc                                                   20


<210> 11399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTCGATT

<400> 11399
ggtccatctg gatcagtata                                                   20


<210> 11400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGGGTTT

<400> 11400
tctggatcag tatatttcga                                                   20


<210> 11401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGGGATT

<400> 11401
cagtatattt cgattgggtt                                                   20


<210> 11402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCAGATT

<400> 11402
ctctggtgcc attgctgttg                                                   20


<210> 11403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGCTT

<400> 11403
caaagttggc tgtgatgaca                                                   20


<210> 11404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGCTT

<400> 11404
ttggctgtga tgacactctg                                                   20


<210> 11405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGTTT

<400> 11405
caagttcagc tggaagtgac                                                   20


<210> 11406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCTGTTT

<400> 11406
ccacaggctc acagtctttg                                                   20


<210> 11407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGATT

<400> 11407
tctgtgaagg ccaggacccc                                                   20


<210> 11408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAAGATT

<400> 11408
cctctcccta cctcctactg                                                   20


<210> 11409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGTTT

<400> 11409
cctcctactg tgaagattga                                                   20


<210> 11410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAGGATT

<400> 11410
gtgttaatta caagggggcc                                                   20


<210> 11411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGGGATT

<400> 11411
ctggctgaca gctaaagcat                                                   20


<210> 11412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGTTT

<400> 11412
gctgtctgca caatgcctta                                                   20


<210> 11413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGTTT

<400> 11413
tttttttttt tttcggttcc                                                   20


<210> 11414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAGGTTT

<400> 11414
ctttatgtta gggcctggag                                                   20


<210> 11415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGATGTTT

<400> 11415
ctatatgatg tctaacttga                                                   20


<210> 11416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTTGATT

<400> 11416
atgatgtcta acttgaagat                                                   20


<210> 11417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGATT

<400> 11417
acttgggaaa taattataat                                                   20


<210> 11418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGTTT

<400> 11418
tggaagacct tctgtgaatt                                                   20


<210> 11419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGATT

<400> 11419
ggaggtaagg agagagggta                                                   20


<210> 11420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGGGTTT

<400> 11420
gagggtagaa agattgatat                                                   20


<210> 11421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGCTT

<400> 11421
aagattgata tgtgggtttt                                                   20


<210> 11422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGGGATT

<400> 11422
tgcttatttt ccagctctat                                                   20


<210> 11423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTATGTTT

<400> 11423
tcatagaact aagtacttgg                                                   20


<210> 11424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACATGATT

<400> 11424
gacacagaag gacaaaaacg                                                   20


<210> 11425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTGGTTT

<400> 11425
atgggagcag agaatagaat                                                   20


<210> 11426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACATGTTT

<400> 11426
gaaatatttg gaggttatgg                                                   20


<210> 11427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGTTT

<400> 11427
tttctggcat tgatggtggt                                                   20


<210> 11428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATAGCTT

<400> 11428
agttgtgtac attaaacatg                                                   20


<210> 11429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGTTT

<400> 11429
gaaatacacg caacccaagg                                                   20


<210> 11430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCATGATT

<400> 11430
atgccaggtg aagctggtga                                                   20


<210> 11431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAAGATT

<400> 11431
tgacaggcag caagttcatt                                                   20


<210> 11432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGCTT

<400> 11432
agattggagc ctgttctaaa                                                   20


<210> 11433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCTGCTT

<400> 11433
tataaaataa ggataataac                                                   20


<210> 11434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGAGATT

<400> 11434
tccctaatag aacagttgtg                                                   20


<210> 11435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACAGATT

<400> 11435
caatccatct ccttttccag                                                   20


<210> 11436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCTGCTT

<400> 11436
ctcacattac accacctgcc                                                   20


<210> 11437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGTGATT

<400> 11437
cggtctgagg ttctcaggag                                                   20


<210> 11438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGTTT

<400> 11438
aaaagttggt tggttatttc                                                   20


<210> 11439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGGGCTT

<400> 11439
caaagacccc caaacagagg                                                   20


<210> 11440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTTGATT

<400> 11440
gaagacggcc acaaagaact                                                   20


<210> 11441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGCTT

<400> 11441
aggaccatga tggtgatgtc                                                   20


<210> 11442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGTTT

<400> 11442
ggcatctgtg ttatctgtag                                                   20


<210> 11443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGTTT

<400> 11443
gtcttctcta ctagacaatg                                                   20


<210> 11444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGTTT

<400> 11444
aagggctata ccttccttaa                                                   20


<210> 11445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGCTT

<400> 11445
gcacattgca agagttcaag                                                   20


<210> 11446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTTGTTT

<400> 11446
agggcgtagg gtcaagtctt                                                   20


<210> 11447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCACGCTT

<400> 11447
cttgatccca accccattcc                                                   20


<210> 11448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGCTT

<400> 11448
ctgtgtcttg taaaacccct                                                   20


<210> 11449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAAGCTT

<400> 11449
tgtaaaaccc cttcttgctt                                                   20


<210> 11450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTAGTTT

<400> 11450
cttgctttga agctttgcca                                                   20


<210> 11451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCCGCTT

<400> 11451
ttttgtcact tcttcattac                                                   20


<210> 11452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGTTT

<400> 11452
atgtgcatta ctctttgtct                                                   20


<210> 11453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTAGTTT

<400> 11453
attgcacaaa tctctaatga                                                   20


<210> 11454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGCTT

<400> 11454
cactcctcag cccacatcaa                                                   20


<210> 11455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGATT

<400> 11455
agcttttgcc tctatcctga                                                   20


<210> 11456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGACGCTT

<400> 11456
tcccataata ttagatccaa                                                   20


<210> 11457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTTGCTT

<400> 11457
agtacccttc taccttgaaa                                                   20


<210> 11458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGCTT

<400> 11458
gtctccacca tgccttacat                                                   20


<210> 11459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACTGTTT

<400> 11459
tatatgtgca acttttggcc                                                   20


<210> 11460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGCTT

<400> 11460
tgatgaggct gatccttgcc                                                   20


<210> 11461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGGGATT

<400> 11461
acatctttcc tggggcagga                                                   20


<210> 11462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAAGTTT

<400> 11462
catcgttaag tggctgggtg                                                   20


<210> 11463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTAGCTT

<400> 11463
attctgactt tagggaatgg                                                   20


<210> 11464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGATT

<400> 11464
ggagtagctt gctagctgct                                                   20


<210> 11465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGTGATT

<400> 11465
gctctcagag acgatgaagt                                                   20


<210> 11466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATTGATT

<400> 11466
tcagagacga tgaagtgggt                                                   20


<210> 11467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGCTT

<400> 11467
tataaagtgg agtatgtgag                                                   20


<210> 11468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATTGATT

<400> 11468
gagtatgtga gagctgcttt                                                   20


<210> 11469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAAGATT

<400> 11469
taacttttcc tatggaagaa                                                   20


<210> 11470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGCTT

<400> 11470
atggggcaga aatcctgtgt                                                   20


<210> 11471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCAGCTT

<400> 11471
gtcagtgctt tgctggtatg                                                   20


<210> 11472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGATT

<400> 11472
gagtgggaat ttccttttgc                                                   20


<210> 11473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCGGCTT

<400> 11473
actttgaaga gggaagatga                                                   20


<210> 11474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGCTT

<400> 11474
ggagtgcagc catctgcagg                                                   20


<210> 11475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGCTT

<400> 11475
atctgcaggt gctgcttgga                                                   20


<210> 11476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGATT

<400> 11476
gctgcttgga ctctgctttg                                                   20


<210> 11477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGTTT

<400> 11477
tgttggcatc cctgccactt                                                   20


<210> 11478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 11478
gcatccctgc cacttcaaag                                                   20


<210> 11479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGTGTTT

<400> 11479
aaattaggga acaaaggaaa                                                   20


<210> 11480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTTGCTT

<400> 11480
aacaaaggaa agagtgttta                                                   20


<210> 11481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAGGTTT

<400> 11481
ctcaggaaca gaattggtta                                                   20


<210> 11482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGCTT

<400> 11482
catcctcgga ggatcttagt                                                   20


<210> 11483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGTGATT

<400> 11483
tgcagcttaa ttaggagaaa                                                   20


<210> 11484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATATGATT

<400> 11484
ctccagggtc cctttttgaa                                                   20


<210> 11485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGCTT

<400> 11485
tgttgtcttc cttgagggga                                                   20


<210> 11486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGATT

<400> 11486
gaagaagctg ggatgtcaaa                                                   20


<210> 11487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCATGTTT

<400> 11487
ggggaaggtg ccaaaaactt                                                   20


<210> 11488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGATT

<400> 11488
tccttggcat ctggctcaaa                                                   20


<210> 11489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGCTT

<400> 11489
gtaaaggcca gtgtggactc                                                   20


<210> 11490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTTGCTT

<400> 11490
aggccagtgt ggactcagct                                                   20


<210> 11491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGATT

<400> 11491
ggttcactca aatccagtta                                                   20


<210> 11492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGTGATT

<400> 11492
tccagttatc ttgattgtat                                                   20


<210> 11493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGTTT

<400> 11493
tcatcacttt tttctcttgt                                                   20


<210> 11494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGTTT

<400> 11494
tgtttttcac tttgttctga                                                   20


<210> 11495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTTGATT

<400> 11495
taaattatgc aaatcctata                                                   20


<210> 11496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATAGCTT

<400> 11496
accttgattt aaaaaaatct                                                   20


<210> 11497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGCTT

<400> 11497
tctccataat tcatttaggg                                                   20


<210> 11498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGATT

<400> 11498
aattgtgtca tcagcaatac                                                   20


<210> 11499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGTTT

<400> 11499
aatgctgcat cttagccaca                                                   20


<210> 11500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAGGCTT

<400> 11500
gtgctatctt agggcctctc                                                   20


<210> 11501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGTTT

<400> 11501
cttagggcct ctcagaggct                                                   20


<210> 11502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAAGTTT

<400> 11502
agaccatgat acataaccac                                                   20


<210> 11503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTAGCTT

<400> 11503
tctaactacc cttactgtca                                                   20


<210> 11504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGCTT

<400> 11504
ctaaaactgt tggagaaact                                                   20


<210> 11505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACAGATT

<400> 11505
agaaactcag tgcttccccc                                                   20


<210> 11506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTATGTTT

<400> 11506
atttcaaata gctgtaaaag                                                   20


<210> 11507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTTGCTT

<400> 11507
tgtttactcc agaagaccag                                                   20


<210> 11508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTGGATT

<400> 11508
acacaggcat agactgtcat                                                   20


<210> 11509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGGGCTT

<400> 11509
ggctcaccag gggccgtggg                                                   20


<210> 11510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGGGCTT

<400> 11510
ggggccgtgg gatgggcttc                                                   20


<210> 11511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCAGTTT

<400> 11511
gcctgggtct ctaaagcaaa                                                   20


<210> 11512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGGGCTT

<400> 11512
gttcattcca gtaaaattct                                                   20


<210> 11513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGATT

<400> 11513
cacagtccct cccagggggc                                                   20


<210> 11514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGATGTTT

<400> 11514
gccagaaact gcaccaacga                                                   20


<210> 11515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAGGATT

<400> 11515
aacgaagatg ttttcctccc                                                   20


<210> 11516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTAGTTT

<400> 11516
ttcctccctt aggattgggt                                                   20


<210> 11517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGATT

<400> 11517
tagtttttct ttaggggccc                                                   20


<210> 11518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGCTT

<400> 11518
tcttcattca aactctcacc                                                   20


<210> 11519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACATGTTT

<400> 11519
gaaagccacc tattttaata                                                   20


<210> 11520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGGGCTT

<400> 11520
tgagaagatc tgtggacaca                                                   20


<210> 11521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAGGATT

<400> 11521
gtcatgctga gaactctgac                                                   20


<210> 11522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGTTT

<400> 11522
ctgaccaagg attcagtaga                                                   20


<210> 11523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGTTT

<400> 11523
acctaatatc tccctctgta                                                   20


<210> 11524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGTTT

<400> 11524
tctgtaatct gtttcttgac                                                   20


<210> 11525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGATT

<400> 11525
tctcatctgt aaaatgagag                                                   20


<210> 11526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATTGCTT

<400> 11526
atctgtaaaa tgagagaaat                                                   20


<210> 11527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAGGATT

<400> 11527
cttatgctca gaaccctggg                                                   20


<210> 11528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAGGATT

<400> 11528
ttatgctcag tgatctttgt                                                   20


<210> 11529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 11529
tcagtgatct ttgttcagga                                                   20


<210> 11530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGGGTTT

<400> 11530
atgagaaaac tgagactcag                                                   20


<210> 11531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAGGTTT

<400> 11531
gttgagtcag gaatgcaaac                                                   20


<210> 11532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGATT

<400> 11532
ttataaacat gagaggttat                                                   20


<210> 11533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTCGATT

<400> 11533
aacatgagag gttatctggg                                                   20


<210> 11534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGGGATT

<400> 11534
cctccccatc ccaaggaggg                                                   20


<210> 11535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCTGCTT

<400> 11535
agttctagat ccctttcttt                                                   20


<210> 11536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTGGCTT

<400> 11536
agtgatgggc tgtgagtagt                                                   20


<210> 11537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAGGCTT

<400> 11537
tgggcaggga acaggaaata                                                   20


<210> 11538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTTGATT

<400> 11538
caccacttat cttttttttc                                                   20


<210> 11539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGATT

<400> 11539
tgtcaattat gaccccaaca                                                   20


<210> 11540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGTGATT

<400> 11540
taagacatgg acctgggtgc                                                   20


<210> 11541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCAGGATT

<400> 11541
agtaactgtg tagagcacat                                                   20


<210> 11542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTGGCTT

<400> 11542
ccccaatagt gtctccccag                                                   20


<210> 11543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGAGATT

<400> 11543
ttcttttctt ttcttttttt                                                   20


<210> 11544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGATT

<400> 11544
aacttctgcc tcccgggttc                                                   20


<210> 11545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGGGTTT

<400> 11545
ctttcatatt ttagtagaga                                                   20


<210> 11546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTAGGATT

<400> 11546
cacctcggcc tcccaaagtg                                                   20


<210> 11547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGTTT

<400> 11547
accactgcgc ctggcccatc                                                   20


<210> 11548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGATT

<400> 11548
cctgggtttt atgatagttc                                                   20


<210> 11549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTTGATT

<400> 11549
acctcattcc tccctatgca                                                   20


<210> 11550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTTGCTT

<400> 11550
caccttgatt tagctactac                                                   20


<210> 11551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGCTT

<400> 11551
actgtctctt agaggttatc                                                   20


<210> 11552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGGGCTT

<400> 11552
ggagagagtc ctgtgttgga                                                   20


<210> 11553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGATT

<400> 11553
gttacttgac taatctcata                                                   20


<210> 11554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCTGTTT

<400> 11554
tttaaagtaa tcccacatgt                                                   20


<210> 11555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAGGTTT

<400> 11555
gtctgctctg tgcacttgcc                                                   20


<210> 11556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGCTT

<400> 11556
aagacctcca tgttcctgcc                                                   20


<210> 11557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGTTT

<400> 11557
gcctgttaca gcacttaatg                                                   20


<210> 11558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGTTT

<400> 11558
ctgttttaat tcacctatta                                                   20


<210> 11559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGATT

<400> 11559
cctggcatac cagagctact                                                   20


<210> 11560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGTGATT

<400> 11560
ggtagatgaa ggcaagaaat                                                   20


<210> 11561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGTTT

<400> 11561
aagaaagaaa gacaggatga                                                   20


<210> 11562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGTTT

<400> 11562
gtgtctattt tgtacaggtt                                                   20


<210> 11563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGAGTTT

<400> 11563
gacccagaag aagctgccag                                                   20


<210> 11564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTGGATT

<400> 11564
cccaatgccc caccccctct                                                   20


<210> 11565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCTGCTT

<400> 11565
tctctttcta tactcattca                                                   20


<210> 11566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGATT

<400> 11566
agagacattg ggcagctgaa                                                   20


<210> 11567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGTTT

<400> 11567
gggttgcagt gagaagatgg                                                   20


<210> 11568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATAGCTT

<400> 11568
acctaaatcc atattcacaa                                                   20


<210> 11569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGTGTTT

<400> 11569
ctatttcaat cttcgggtcc                                                   20


<210> 11570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 11570
agttaatttc aaaagcccac                                                   20


<210> 11571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGATT

<400> 11571
agggaaaaat ttacaggacc                                                   20


<210> 11572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGTGATT

<400> 11572
tggcaataag aggcagagtt                                                   20


<210> 11573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGATGCTT

<400> 11573
agttgggtga ttgagataat                                                   20


<210> 11574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CGATGATT

<400> 11574
gataatagat gcttgtggag                                                   20


<210> 11575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAGGATT

<400> 11575
gatgcttgtg gagcgatgat                                                   20


<210> 11576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAAGTTT

<400> 11576
taccaaaacc tgcagaccag                                                   20


<210> 11577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 11577
acctgcagac cagagaagtt                                                   20


<210> 11578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTTGTTT

<400> 11578
gcagaccaga gaagtttttt                                                   20


<210> 11579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGTGATT

<400> 11579
accaccacac ctcgtggtgg                                                   20


<210> 11580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGGGTTT

<400> 11580
ttttgtactt ttagcagaga                                                   20


<210> 11581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTGGTTT

<400> 11581
ggtttcggca tgttggccag                                                   20


<210> 11582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGATT

<400> 11582
cgcctcagcc tcccaaagtg                                                   20


<210> 11583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAAGTTT

<400> 11583
accgtgcctg gccagatgag                                                   20


<210> 11584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGGGCTT

<400> 11584
cgcagagcgc gaagggttcg                                                   20


<210> 11585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTAGGTTT

<400> 11585
gagagggcag aaacatcact                                                   20


<210> 11586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGTTT

<400> 11586
actccaatga gaggtctaga                                                   20


<210> 11587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAAGCTT

<400> 11587
aacctctggt acgtaggtgg                                                   20


<210> 11588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACTGATT

<400> 11588
tcaggcctca acaaccttga                                                   20


<210> 11589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTGGTTT

<400> 11589
agaagtgggg tggaaagaat                                                   20


<210> 11590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCTGATT

<400> 11590
gggtctaatt cccatttgaa                                                   20


<210> 11591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGAGCTT

<400> 11591
catttgaacc ctgatttttt                                                   20


<210> 11592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGTTT

<400> 11592
gatagctctg cagttcttca                                                   20


<210> 11593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGCTT

<400> 11593
tctggtatgg gtccatgaga                                                   20


<210> 11594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCAGTTT

<400> 11594
ttgtgagccc cttttggtct                                                   20


<210> 11595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGCTT

<400> 11595
gatggtgggc tgaattcagg                                                   20


<210> 11596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGCTT

<400> 11596
cagttaggtg ggatgcacac                                                   20


<210> 11597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGGGCTT

<400> 11597
acacaggagc ttcagaaaag                                                   20


<210> 11598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTGGCTT

<400> 11598
caatgtccat tctttggatg                                                   20


<210> 11599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAGGTTT

<400> 11599
gcctgggtgc atgagggtag                                                   20


<210> 11600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGATT

<400> 11600
gcatctattc tccactgcaa                                                   20


<210> 11601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGCTT

<400> 11601
ggagatagtg agtatttatt                                                   20


<210> 11602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGTTT

<400> 11602
agtgagtatt tattctgtgc                                                   20


<210> 11603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGTGATT

<400> 11603
cagctggatg aaaagttgaa                                                   20


<210> 11604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATAGATT

<400> 11604
aaggatacaa tgataaatag                                                   20


<210> 11605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATTGTTT

<400> 11605
tactatagtt aataatagca                                                   20


<210> 11606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATGGTTT

<400> 11606
ttgtatccct taaaaattga                                                   20


<210> 11607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAAGTTT

<400> 11607
tgctgttctc atgatagtga                                                   20


<210> 11608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGAGTTT

<400> 11608
gatgtgacgg tattataagg                                                   20


<210> 11609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCATGATT

<400> 11609
tcgcacctcc tttccttttg                                                   20


<210> 11610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAGGCTT

<400> 11610
ctttcctttt gccatgattg                                                   20


<210> 11611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCATGCTT

<400> 11611
agaaggatga gtgagtagaa                                                   20


<210> 11612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGATGATT

<400> 11612
gaatgagtga acagaatgtt                                                   20


<210> 11613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGTTT

<400> 11613
aggatgatga atagatggaa                                                   20


<210> 11614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGATT

<400> 11614
gatggaagga agtttagaat                                                   20


<210> 11615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGATGTTT

<400> 11615
tggaagaaat aaagatggat                                                   20


<210> 11616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GACCGTTT

<400> 11616
gatggatgaa atgagtgcat                                                   20


<210> 11617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGTGATT

<400> 11617
aatgagtgca tgaccgttta                                                   20


<210> 11618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGATT

<400> 11618
cacagaatta tcacccatga                                                   20


<210> 11619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGCTT

<400> 11619
atgttctgtg ctgaacctca                                                   20


<210> 11620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGCTT

<400> 11620
gggcagacct tgctgctggc                                                   20


<210> 11621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCTGCTT

<400> 11621
ccaacacagc acatgcctca                                                   20


<210> 11622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGGGATT

<400> 11622
acacagtcaa ttctctaatg                                                   20


<210> 11623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGTGATT

<400> 11623
tgcatatttc atagctcccc                                                   20


<210> 11624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGATT

<400> 11624
ggaccacaga accgcaggtg                                                   20


<210> 11625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAGGATT

<400> 11625
cactttggat gtaaaaatgc                                                   20


<210> 11626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGCTT

<400> 11626
agcccttgag ggccaggtct                                                   20


<210> 11627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGCTT

<400> 11627
accctgtcag tgtactccag                                                   20


<210> 11628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGGGCTT

<400> 11628
actccagcaa agctttcacc                                                   20


<210> 11629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGGGATT

<400> 11629
ccctgaccac agtccctgga                                                   20


<210> 11630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCAGCTT

<400> 11630
ccctggaagg ggatttggta                                                   20


<210> 11631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 11631
tagtcagctt gccagtagca                                                   20


<210> 11632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTGGATT

<400> 11632
gagaaagaaa accttctcaa                                                   20


<210> 11633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGTTT

<400> 11633
caaagggatg ctaacagtga                                                   20


<210> 11634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCAGTTT

<400> 11634
agcatcaacg gatgttcaca                                                   20


<210> 11635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGTTT

<400> 11635
aaattcaaat taaaagaaga                                                   20


<210> 11636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CGGGGTTT

<400> 11636
ttttgtattt ttagtagaga                                                   20


<210> 11637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACCGTTT

<400> 11637
ttttagtaga gacggggttt                                                   20


<210> 11638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGATT

<400> 11638
cgcctcagcc tcccaaagtg                                                   20


<210> 11639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAGGTTT

<400> 11639
ccaaattggc aatgtgactc                                                   20


<210> 11640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGCTT

<400> 11640
gatgcagaca cccccttcct                                                   20


<210> 11641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGCTT

<400> 11641
gaaactgtgt ccaccttggg                                                   20


<210> 11642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGGGATT

<400> 11642
ctcagccagg gacagtgaca                                                   20


<210> 11643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGTGCTT

<400> 11643
ggacagctct ttggtgtcct                                                   20


<210> 11644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGGGCTT

<400> 11644
ctttggtgtc ctttgtgctt                                                   20


<210> 11645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCGGATT

<400> 11645
tttccatggg atcagctgaa                                                   20


<210> 11646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGCTT

<400> 11646
caactgaacc cacatctttt                                                   20


<210> 11647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCCGATT

<400> 11647
aacccacatc ttttctcagc                                                   20


<210> 11648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGAGATT

<400> 11648
tctaggacga ggactaagat                                                   20


<210> 11649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGAGATT

<400> 11649
atgtgtatta gaagtaaaca                                                   20


<210> 11650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGTTT

<400> 11650
gaggttatag aatgcataaa                                                   20


<210> 11651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCATGTTT

<400> 11651
gatgagaaag aggtatacca                                                   20


<210> 11652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGAGTTT

<400> 11652
gtataccagc atgttttcaa                                                   20


<210> 11653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGATGATT

<400> 11653
tctttgagtg atagggaaat                                                   20


<210> 11654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGCTT

<400> 11654
gctggcgcag tgctgcaggt                                                   20


<210> 11655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGCTT

<400> 11655
gccccgaaac tctcttctcc                                                   20


<210> 11656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTAGTTT

<400> 11656
tggctttgcg tcattgccac                                                   20


<210> 11657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCAGTTT

<400> 11657
aaagctgagg ccatgcaccg                                                   20


<210> 11658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTTGTTT

<400> 11658
ggaggcctag atatttagta                                                   20


<210> 11659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGGGCTT

<400> 11659
acctgaagcc cctcatgcct                                                   20


<210> 11660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGAGATT

<400> 11660
ttggtctatt ggcggagtag                                                   20


<210> 11661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGCTT

<400> 11661
ggagtagttg agattgtgta                                                   20


<210> 11662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGAGCTT

<400> 11662
gggcagtgca agcatcacct                                                   20


<210> 11663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACAGATT

<400> 11663
tgcaaattct caggccctgc                                                   20


<210> 11664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGAGATT

<400> 11664
ctgcatttga acaagctcct                                                   20


<210> 11665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAATGATT

<400> 11665
aattttgaga agtgctattg                                                   20


<210> 11666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGAGCTT

<400> 11666
tgctattgta atgattttct                                                   20


<210> 11667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTGGTTT

<400> 11667
agtaattagt agcatttgga                                                   20


<210> 11668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGGGCTT

<400> 11668
aggtcagagg gtgggaagcc                                                   20


<210> 11669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCGGGATT

<400> 11669
agggtgggaa gccaggggct                                                   20


<210> 11670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGTTT

<400> 11670
gggattaaat aagggcaaag                                                   20


<210> 11671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCAGTTT

<400> 11671
gccttttaaa cattttgagt                                                   20


<210> 11672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGCTT

<400> 11672
aggcatacac tcactcactc                                                   20


<210> 11673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAGGTTT

<400> 11673
actcactcaa atgcttgcag                                                   20


<210> 11674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGATT

<400> 11674
actgatgcag ctccagggcc                                                   20


<210> 11675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGATT

<400> 11675
ctccagggcc tttggattgt                                                   20


<210> 11676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAGGATT

<400> 11676
attgtaggag attcctatct                                                   20


<210> 11677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGTTT

<400> 11677
cccatggact cttggtggta                                                   20


<210> 11678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGTTT

<400> 11678
atcatcagtc ttgcccactc                                                   20


<210> 11679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGGGATT

<400> 11679
gggccacgac gtggctggga                                                   20


<210> 11680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGATT

<400> 11680
attcccttta tagaatggac                                                   20


<210> 11681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGCTT

<400> 11681
aaagatgact aagacacagg                                                   20


<210> 11682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGATT

<400> 11682
tctgcttttg agagctaaac                                                   20


<210> 11683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGTTT

<400> 11683
ggtccttcat ggtccaaatc                                                   20


<210> 11684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGTGTTT

<400> 11684
tccaaatcaa gagttttcag                                                   20


<210> 11685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTACGTTT

<400> 11685
agtggtgttt atggtggtga                                                   20


<210> 11686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTGGTTT

<400> 11686
ccccctttca actcaagagg                                                   20


<210> 11687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGGGTTT

<400> 11687
ggctggttta gaactcacgg                                                   20


<210> 11688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACAGCTT

<400> 11688
ggagtgaggc agcaagtggg                                                   20


<210> 11689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTTGTTT

<400> 11689
tgaggcagca agtgggcaca                                                   20


<210> 11690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTGGATT

<400> 11690
cccaggtgag tgttcgctca                                                   20


<210> 11691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAGGATT

<400> 11691
tgccagctca gggatcttcc                                                   20


<210> 11692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGCTT

<400> 11692
gtccaccgtg ctgccctcag                                                   20


<210> 11693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCATGTTT

<400> 11693
cactgcaggt tcaactgcac                                                   20


<210> 11694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAGGCTT

<400> 11694
gctcttctcc ctggagcccc                                                   20


<210> 11695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGCTT

<400> 11695
ataacgactc tcagcattca                                                   20


<210> 11696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATAGCTT

<400> 11696
gctctcatat tagtaaacct                                                   20


<210> 11697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCGGCTT

<400> 11697
ccctcaccca gtgggaacca                                                   20


<210> 11698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGGGCTT

<400> 11698
agctgacatt cttcaagctg                                                   20


<210> 11699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATAGCTT

<400> 11699
tttatagatg cctctttccc                                                   20


<210> 11700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTTGTTT

<400> 11700
tagatgcctc tttccctata                                                   20


<210> 11701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAAGATT

<400> 11701
ttccctatag cttgtttcct                                                   20


<210> 11702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTCGTTT

<400> 11702
gactttcttt gtgcgttgtc                                                   20


<210> 11703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAAGCTT

<400> 11703
tttgacaagc agcatctcat                                                   20


<210> 11704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGTTT

<400> 11704
ctaccaagta ggcattacca                                                   20


<210> 11705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAGGTTT

<400> 11705
atgaataaat ggcggctcag                                                   20


<210> 11706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACAGCTT

<400> 11706
tgggaactga tcttaggtcc                                                   20


<210> 11707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGAGATT

<400> 11707
atacctagaa ccaccctgga                                                   20


<210> 11708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCGGATT

<400> 11708
tatggtgaaa gttgaaattg                                                   20


<210> 11709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGATT

<400> 11709
ccaggataag aaatgaggtt                                                   20


<210> 11710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGTTT

<400> 11710
catcacaggc tgccagagcc                                                   20


<210> 11711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTATGTTT

<400> 11711
aagactatag ctagatagac                                                   20


<210> 11712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTTGTTT

<400> 11712
aagatgtgtg accttaggca                                                   20


<210> 11713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCAGCTT

<400> 11713
cctctctaat cttcattttt                                                   20


<210> 11714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGTTT

<400> 11714
aggctagatc tgcatcattc                                                   20


<210> 11715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGCGCTT

<400> 11715
gttttgatga ctaaatatgt                                                   20


<210> 11716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGTGCTT

<400> 11716
cttgtaaaac actttgcacg                                                   20


<210> 11717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATAGATT

<400> 11717
ttgcacgaag tgcttggctc                                                   20


<210> 11718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGCTT

<400> 11718
aagagcccca aagtaactga                                                   20


<210> 11719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACAGCTT

<400> 11719
ggagagctac agactcaaag                                                   20


<210> 11720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCAGCTT

<400> 11720
aggttagcga gggttgatat                                                   20


<210> 11721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGCTT

<400> 11721
tatattatca aatggctcaa                                                   20


<210> 11722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGATT

<400> 11722
aggacttctt aggatgctgg                                                   20


<210> 11723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCTGTTT

<400> 11723
ctcacctgct gccccccact                                                   20


<210> 11724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGCTT

<400> 11724
ctcaaacgcc aactcctctg                                                   20


<210> 11725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CATGGTTT

<400> 11725
aactcctctg gaaagcttgg                                                   20


<210> 11726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCAGATT

<400> 11726
tcatcctcca agtcatcaag                                                   20


<210> 11727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCGGATT

<400> 11727
tgggcacaga gacccacaca                                                   20


<210> 11728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGAGCTT

<400> 11728
tgctcatccc tggggcctct                                                   20


<210> 11729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGAGTTT

<400> 11729
cagccttgga gctggagagt                                                   20


<210> 11730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCTGTTT

<400> 11730
tgctgaagaa gctgcaaaga                                                   20


<210> 11731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGATT

<400> 11731
ctgaagagaa ggaatggaag                                                   20


<210> 11732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGTTT

<400> 11732
ctttctgaga gcagttgagg                                                   20


<210> 11733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CGAGGCTT

<400> 11733
gagtgacccg cctcagtgga                                                   20


<210> 11734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGCTT

<400> 11734
ctggaatcct gggcacatct                                                   20


<210> 11735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGTTT

<400> 11735
gtgggctcag cctggaagaa                                                   20


<210> 11736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGATT

<400> 11736
gggtggaaaa gactaaagag                                                   20


<210> 11737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTTGCTT

<400> 11737
actaaagagt ctggatttgt                                                   20


<210> 11738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGTTT

<400> 11738
tttgttgttg cttccctttt                                                   20


<210> 11739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGCTT

<400> 11739
tgttgcttcc cttttcttgg                                                   20


<210> 11740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGGGCTT

<400> 11740
gatgtccagg gcaataagaa                                                   20


<210> 11741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGGGCTT

<400> 11741
ctggggcgga gaaggggtat                                                   20


<210> 11742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGGGCTT

<400> 11742
attggcaagt gagtctccag                                                   20


<210> 11743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTAGATT

<400> 11743
ggggcttcct ccaaacatgg                                                   20


<210> 11744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGCTT

<400> 11744
ctgctcccag ctaggacctg                                                   20


<210> 11745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGTTT

<400> 11745
gctcttactt ccctgaataa                                                   20


<210> 11746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGATT

<400> 11746
aaaaatgttt tctgagcccc                                                   20


<210> 11747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACCGTTT

<400> 11747
ttcctttaac agctaataga                                                   20


<210> 11748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGATT

<400> 11748
cccatgagta agcattattt                                                   20


<210> 11749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGATT

<400> 11749
tttaaggaaa ttagatcttg                                                   20


<210> 11750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGATT

<400> 11750
ccacctagta aatggtggag                                                   20


<210> 11751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGTTT

<400> 11751
atgaatccca catgaatttg                                                   20


<210> 11752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGCTT

<400> 11752
ctgggcataa aaatgcagat                                                   20


<210> 11753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATGGATT

<400> 11753
gtcaagaaaa ggatgaggca                                                   20


<210> 11754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTAGTTT

<400> 11754
gatatttttt cggttgttac                                                   20


<210> 11755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGCTT

<400> 11755
tacggtagtt ttcccctagg                                                   20


<210> 11756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGTTT

<400> 11756
gaggttcccc agtgccccca                                                   20


<210> 11757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGTGTTT

<400> 11757
gtttccgatg atcttgatga                                                   20


<210> 11758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAGGATT

<400> 11758
atgagtgtgt ttaaggtggg                                                   20


<210> 11759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCAGCTT

<400> 11759
ttaaggtggg ccaggatttg                                                   20


<210> 11760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAGGTTT

<400> 11760
ctgcagagaa acagagaccg                                                   20


<210> 11761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGTTT

<400> 11761
tgtgctcatt acctttcatc                                                   20


<210> 11762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGCGTTT

<400> 11762
cctctcatcc cattaaacca                                                   20


<210> 11763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGCTT

<400> 11763
aaaccagggc gttttctgga                                                   20


<210> 11764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGCTT

<400> 11764
tctatggttc ataagtatca                                                   20


<210> 11765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAAGCTT

<400> 11765
gggctcacaa ataagtgaga                                                   20


<210> 11766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCAGCTT

<400> 11766
ggacaacatc tgttgctccc                                                   20


<210> 11767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCATGATT

<400> 11767
agctttgaaa ctgcaaatgt                                                   20


<210> 11768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTTGATT

<400> 11768
tcatggactc agcattcata                                                   20


<210> 11769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATGGTTT

<400> 11769
gctcttgctc tcatggaacc                                                   20


<210> 11770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGTTT

<400> 11770
atcatcaagc ataaaaatgt                                                   20


<210> 11771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGTGTTT

<400> 11771
ctgtcagtct gtcagtcaag                                                   20


<210> 11772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGCTT

<400> 11772
gcacctacta agagccaggc                                                   20


<210> 11773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAGGTTT

<400> 11773
cgtgagtaaa tcccacggga                                                   20


<210> 11774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGCTT

<400> 11774
tactctcctc atatgggaag                                                   20


<210> 11775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCTGCTT

<400> 11775
taagcctagc aggaatttct                                                   20


<210> 11776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAGGATT

<400> 11776
aacaacaaag tggtgctcat                                                   20


<210> 11777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAGGTTT

<400> 11777
tggaggaacc tgcctttatc                                                   20


<210> 11778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGTTT

<400> 11778
tttcaaacta ttccctcaaa                                                   20


<210> 11779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAGGTTT

<400> 11779
aaaattaaaa atattatgaa                                                   20


<210> 11780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCAGATT

<400> 11780
atattatgaa gaaggtttgc                                                   20


<210> 11781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACAGTTT

<400> 11781
aaggtttgca tcagatttga                                                   20


<210> 11782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGTTT

<400> 11782
agacatagag gatagaatga                                                   20


<210> 11783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGATT

<400> 11783
attgaagaaa attacaaaac                                                   20


<210> 11784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAAGATT

<400> 11784
gcagaacacc aaagatggat                                                   20


<210> 11785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAGGCTT

<400> 11785
agaaatcaat aactaaattt                                                   20


<210> 11786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGAGTTT

<400> 11786
tcagtaactt acaaaaattc                                                   20


<210> 11787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGAGTTT

<400> 11787
ttggaaccag gatggccgac                                                   20


<210> 11788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGCTT

<400> 11788
ccgactggag tttgtgcaga                                                   20


<210> 11789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCAGATT

<400> 11789
catattgcat actaactccc                                                   20


<210> 11790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGCTT

<400> 11790
gacagcacag ggagacagat                                                   20


<210> 11791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCAGCTT

<400> 11791
gacctcctgt cttcttgcca                                                   20


<210> 11792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAAGCTT

<400> 11792
ttgccagcca gcttgcagta                                                   20


<210> 11793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGCTT

<400> 11793
caaaagcctg gtgtcctcgt                                                   20


<210> 11794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTGGCTT

<400> 11794
ttggcttcca aagtcatagt                                                   20


<210> 11795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GACTGTTT

<400> 11795
tcctcccaga cacaacggaa                                                   20


<210> 11796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGTTT

<400> 11796
gacacaacgg aagactgttt                                                   20


<210> 11797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGCTT

<400> 11797
aacggaagac tgttttccag                                                   20


<210> 11798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGCTT

<400> 11798
cttgaagtag acactcccag                                                   20


<210> 11799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACAGATT

<400> 11799
acatctctat tatgttaact                                                   20


<210> 11800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGCTT

<400> 11800
cttatcttga gtaatggaga                                                   20


<210> 11801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTGGCTT

<400> 11801
aaaagcatca actatgtggc                                                   20


<210> 11802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAGGCTT

<400> 11802
caacaaggaa gctgatagga                                                   20


<210> 11803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGGGTTT

<400> 11803
tgaaccagca accctagggg                                                   20


<210> 11804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGATT

<400> 11804
ttggtcaaga cagtacaaga                                                   20


<210> 11805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGATT

<400> 11805
caagaaagag attagctcag                                                   20


<210> 11806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTGGTTT

<400> 11806
attagctcag gaaagattta                                                   20


<210> 11807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAAGTTT

<400> 11807
aataaaagaa aatataatcc                                                   20


<210> 11808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGACGATT

<400> 11808
aatccagaag tttagagcct                                                   20


<210> 11809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TACTGCTT

<400> 11809
cttgacgatt tagggaactg                                                   20


<210> 11810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGATT

<400> 11810
atttagggaa ctgtactgct                                                   20


<210> 11811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGGGATT

<400> 11811
tagattccag gcagtgagca                                                   20


<210> 11812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGCTT

<400> 11812
ttaaatgaaa caactcttag                                                   20


<210> 11813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGTTT

<400> 11813
gcttgtagta atggtgtagc                                                   20


<210> 11814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTAAGTTT

<400> 11814
aatgagaggt ctgaagccat                                                   20


<210> 11815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGTTT

<400> 11815
ccctgactga aaaagccttt                                                   20


<210> 11816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGCTT

<400> 11816
gtttaaacct taaaacaaac                                                   20


<210> 11817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGCTT

<400> 11817
tggagtccca cctagagctg                                                   20


<210> 11818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGTTT

<400> 11818
acctttattg gggtcagtta                                                   20


<210> 11819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGAGATT

<400> 11819
tggggtcagt tactcagttt                                                   20


<210> 11820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTAGCTT

<400> 11820
tagagattgt ctgtataata                                                   20


<210> 11821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CATTGATT

<400> 11821
taataggtag ctttattttt                                                   20


<210> 11822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGATT

<400> 11822
aagttgtctt ggaggaaggt                                                   20


<210> 11823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGCTT

<400> 11823
gttaaagatt ttagctaact                                                   20


<210> 11824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGATT

<400> 11824
agattttagc taacttttgg                                                   20


<210> 11825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGAGTTT

<400> 11825
ttatttattt atttttgaga                                                   20


<210> 11826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGATT

<400> 11826
tccctcagcc tcccaagtag                                                   20


<210> 11827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGATT

<400> 11827
tgcctgcgcc tccaacagtg                                                   20


<210> 11828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATTGTTT

<400> 11828
actgcccctg gccttctttt                                                   20


<210> 11829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGATT

<400> 11829
gctcactgca acctctgtct                                                   20


<210> 11830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGATT

<400> 11830
tgcctcaccc tcctgagtag                                                   20


<210> 11831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGGGTTT

<400> 11831
ttatatattt ttagtagaga                                                   20


<210> 11832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGATT

<400> 11832
caccttggcc tcccaaaatt                                                   20


<210> 11833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGCTT

<400> 11833
gagccacccc acctggcccc                                                   20


<210> 11834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTAGGTTT

<400> 11834
aaaaatgcat cacgatcaag                                                   20


<210> 11835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTTGATT

<400> 11835
ggtttgagct gggaatgtaa                                                   20


<210> 11836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACAGATT

<400> 11836
ttaatataat tcaccacttt                                                   20


<210> 11837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACATGATT

<400> 11837
aacagattga aggagaaaat                                                   20


<210> 11838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGATT

<400> 11838
aagagaactt cctgaactga                                                   20


<210> 11839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGATT

<400> 11839
ttagaggtgg tgaaatattg                                                   20


<210> 11840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAGGATT

<400> 11840
gtaaaaagaa cctaatggca                                                   20


<210> 11841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGATT

<400> 11841
ctcattgtta ttttcacatg                                                   20


<210> 11842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGATT

<400> 11842
gatcagaaga ctgaattatg                                                   20


<210> 11843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCAGTTT

<400> 11843
tccctaatgg gaaaaacaat                                                   20


<210> 11844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTGGATT

<400> 11844
gatattcttg aagtaaatta                                                   20


<210> 11845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTTGATT

<400> 11845
tgaagtaaat taggtggatt                                                   20


<210> 11846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAGGCTT

<400> 11846
gactaacaga gcaaatggag                                                   20


<210> 11847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGTGTTT

<400> 11847
ccttccttca atcaatcaac                                                   20


<210> 11848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGTTT

<400> 11848
taaaacggta gacaagaaac                                                   20


<210> 11849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGTTT

<400> 11849
ggtgacaagt gcattgaaca                                                   20


<210> 11850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCTGATT

<400> 11850
gagactggtg aactggcagg                                                   20


<210> 11851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGATT

<400> 11851
ttgtacacca tcatgaggag                                                   20


<210> 11852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGGGATT

<400> 11852
tgtgtgtgtg tgtgtgtgtt                                                   20


<210> 11853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGCTT

<400> 11853
ttgtgggatt gatggtatat                                                   20


<210> 11854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGTTT

<400> 11854
aagctttctg ttcaatctgc                                                   20


<210> 11855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CGGTGATT

<400> 11855
ccaggaaact gaccagctgg                                                   20


<210> 11856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAGGTTT

<400> 11856
atttgactta gactctccgg                                                   20


<210> 11857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGTGATT

<400> 11857
cgcaaagagg cagagggaaa                                                   20


<210> 11858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGAGTTT

<400> 11858
gaggcagagg gaaaaggtga                                                   20


<210> 11859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTTGTTT

<400> 11859
cagagggaaa aggtgattga                                                   20


<210> 11860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTTGTTT

<400> 11860
aagtaaactt gcctattttt                                                   20


<210> 11861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTAAGCTT

<400> 11861
agcacataga ccttaaaaca                                                   20


<210> 11862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGCTT

<400> 11862
tagaccttaa aacactaagc                                                   20


<210> 11863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTCGTTT

<400> 11863
tccccaagtg tagcagaaat                                                   20


<210> 11864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CGCTGTTT

<400> 11864
ttttttttga gacggagtcc                                                   20


<210> 11865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCGGATT

<400> 11865
agtcccgctg tttagcccag                                                   20


<210> 11866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CGGGGTTT

<400> 11866
ttttgtattt ttagtagaga                                                   20


<210> 11867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGATT

<400> 11867
tgcctcggcc tcccaaagtg                                                   20


<210> 11868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGACGATT

<400> 11868
tgtgatatct cctgctctct                                                   20


<210> 11869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTAGCTT

<400> 11869
ataggtacct tatattgacc                                                   20


<210> 11870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGATT

<400> 11870
agaaatctgt ccttctaaaa                                                   20


<210> 11871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTAAGATT

<400> 11871
tgtgatttaa ttctgacctt                                                   20


<210> 11872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCAGCTT

<400> 11872
cctgggatgg tgacagtacc                                                   20


<210> 11873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGCGTTT

<400> 11873
cttaggcaga tgccatcaac                                                   20


<210> 11874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACATGCTT

<400> 11874
tggcacagct gtgtctcagg                                                   20


<210> 11875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGTGTTT

<400> 11875
catgctttat ttggtcttta                                                   20


<210> 11876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTGGATT

<400> 11876
tctttagagt gtttttaaaa                                                   20


<210> 11877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGATT

<400> 11877
taaagacatt tgcacaaaaa                                                   20


<210> 11878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTCGCTT

<400> 11878
ctttctttca tctgtctttc                                                   20


<210> 11879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CGGGGTTT

<400> 11879
tttttcattt tttgtagaga                                                   20


<210> 11880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTAGGATT

<400> 11880
tgcctcggcc tcccaaagta                                                   20


<210> 11881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CATTGATT

<400> 11881
cacctggcct gagatggtca                                                   20


<210> 11882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGCTT

<400> 11882
catccctccc aggagttgtg                                                   20


<210> 11883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGAGTTT

<400> 11883
atgtcactgc acatgggcat                                                   20


<210> 11884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGATT

<400> 11884
caacacttgt caggaccttg                                                   20


<210> 11885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGTTT

<400> 11885
gaagattgtt ggatactccc                                                   20


<210> 11886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGATT

<400> 11886
cagggctccc agttaatact                                                   20


<210> 11887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAAGCTT

<400> 11887
tcccaagagt cagtgagatg                                                   20


<210> 11888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAGGTTT

<400> 11888
ccgacactcc tgggaatctg                                                   20


<210> 11889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGTTT

<400> 11889
ctgtagaggg cgtcctggag                                                   20


<210> 11890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGTGCTT

<400> 11890
gagactaata ggcaggttga                                                   20


<210> 11891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGATT

<400> 11891
aggtgcttga gacattgggg                                                   20


<210> 11892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTGGATT

<400> 11892
ggggctctgg agtcagacaa                                                   20


<210> 11893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGCTT

<400> 11893
ctggatttga gatccaggtc                                                   20


<210> 11894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTCGCTT

<400> 11894
gagatccagg tctgtggctt                                                   20


<210> 11895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTTGCTT

<400> 11895
tccaggtctg tggcttattc                                                   20


<210> 11896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGCGTTT

<400> 11896
tgttgtgagc ataaaatgag                                                   20


<210> 11897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGATT

<400> 11897
tgctcagtaa gtattagctg                                                   20


<210> 11898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGCTT

<400> 11898
tatttgataa gagacgagga                                                   20


<210> 11899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGAGTTT

<400> 11899
tgtcttccct gaatctgggt                                                   20


<210> 11900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAGGCTT

<400> 11900
gcggaagctc cgcagcacag                                                   20


<210> 11901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAATGATT

<400> 11901
ataatagtat gggtcgaagg                                                   20


<210> 11902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAAGCTT

<400> 11902
gtaaagacct aggagtggaa                                                   20


<210> 11903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 11903
atttacaaaa tagaaaatcc                                                   20


<210> 11904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAGGATT

<400> 11904
ctatgttatc tgtgggctcc                                                   20


<210> 11905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGTTT

<400> 11905
ttctcagggg ctgtgcatgc                                                   20


<210> 11906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTGGATT

<400> 11906
gggttgtggg acatcacaga                                                   20


<210> 11907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTAGCTT

<400> 11907
aaatcccagc ccagacattt                                                   20


<210> 11908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTAAGCTT

<400> 11908
ccagacattt cctagcttat                                                   20


<210> 11909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAATGATT

<400> 11909
gtaacagtga ctagtaagaa                                                   20


<210> 11910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTAAGATT

<400> 11910
agaacaatga ttcattgcct                                                   20


<210> 11911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGTGCTT

<400> 11911
ggaaagcaac gaccagggtc                                                   20


<210> 11912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGTTT

<400> 11912
tatggagaag aaaacaggct                                                   20


<210> 11913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GACTGATT

<400> 11913
gtgactttct catgccacaa                                                   20


<210> 11914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGCTT

<400> 11914
aggcaccaag cacatgactt                                                   20


<210> 11915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGCTT

<400> 11915
tgggaaaggc cttttctctc                                                   20


<210> 11916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGATT

<400> 11916
tgctgccaaa acatgaggca                                                   20


<210> 11917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTGGATT

<400> 11917
actgctgccc ctttcacagc                                                   20


<210> 11918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTGGTTT

<400> 11918
ccctggatta tggcggaggg                                                   20


<210> 11919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGCTT

<400> 11919
ggtgaatcca gtaggtcacc                                                   20


<210> 11920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGCTT

<400> 11920
aaggcaggat gctgaccctt                                                   20


<210> 11921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGTGTTT

<400> 11921
cttctgccta tcatgtgtgc                                                   20


<210> 11922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTGGCTT

<400> 11922
cacacacgca agtcttgtga                                                   20


<210> 11923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCGGGCTT

<400> 11923
taattcaggg gttaagaaaa                                                   20


<210> 11924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGATT

<400> 11924
aactcaactc tatgatcttg                                                   20


<210> 11925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATGGATT

<400> 11925
cagtatatag tgaaatccag                                                   20


<210> 11926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGCTT

<400> 11926
aaagaaaagt tccgacttcc                                                   20


<210> 11927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTTGTTT

<400> 11927
tgcttttgtt acaacagcaa                                                   20


<210> 11928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCATGTTT

<400> 11928
ttacaacagc aaccttgttt                                                   20


<210> 11929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGATT

<400> 11929
tggaaggaaa cagacaagtc                                                   20


<210> 11930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTATGTTT

<400> 11930
agaaaattca agtggttgtc                                                   20


<210> 11931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGCTT

<400> 11931
ggctctcctg gttcactttc                                                   20


<210> 11932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CATGGCTT

<400> 11932
acgatgttgc ctatctggag                                                   20


<210> 11933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGAGCTT

<400> 11933
caagcccaaa gagaattgtc                                                   20


<210> 11934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCAGCTT

<400> 11934
tgtccttact tctcaatttg                                                   20


<210> 11935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTAGATT

<400> 11935
ttacttctca atttgcccag                                                   20


<210> 11936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTATGCTT

<400> 11936
tggctggaaa aaatacacaa                                                   20


<210> 11937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGTTT

<400> 11937
tgccctgccc agaaatctgg                                                   20


<210> 11938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GACTGTTT

<400> 11938
attccttcat tcttccagat                                                   20


<210> 11939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACATGCTT

<400> 11939
ccattgccat gagcaggtaa                                                   20


<210> 11940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CGCGGCTT

<400> 11940
taaacatgct ttaattatct                                                   20


<210> 11941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TACTGCTT

<400> 11941
gaccccatgc tctctttcat                                                   20


<210> 11942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGTTT

<400> 11942
ttgacagtaa aattccttgc                                                   20


<210> 11943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACTGCTT

<400> 11943
agcccctgga atctgacttt                                                   20


<210> 11944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGATT

<400> 11944
aactgcttcc aaattcaaat                                                   20


<210> 11945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGCTT

<400> 11945
gctctgggga ctgcatcatc                                                   20


<210> 11946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGTTT

<400> 11946
tttctccact tcttttcact                                                   20


<210> 11947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCTGCTT

<400> 11947
tttttgtctc ccttttcctt                                                   20


<210> 11948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTAGCTT

<400> 11948
aataactcaa gcattctcac                                                   20


<210> 11949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGTTT

<400> 11949
gcattctcac cttagcttct                                                   20


<210> 11950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTAGGCTT

<400> 11950
ttctgatccc ttcctgaaca                                                   20


<210> 11951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTAGCTT

<400> 11951
acctcgatgg agggcaattt                                                   20


<210> 11952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAGGTTT

<400> 11952
tggagggcaa tttcttagct                                                   20


<210> 11953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CATTGTTT

<400> 11953
gggcaaagaa agatgatgtc                                                   20


<210> 11954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCAGATT

<400> 11954
tacattgtga aaaagaatga                                                   20


<210> 11955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGCTT

<400> 11955
tagtgtgtgt atgtgcatgc                                                   20


<210> 11956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CATTGCTT

<400> 11956
gtgcttatat atgcatagaa                                                   20


<210> 11957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGTTT

<400> 11957
tgtcattgca tacacacttg                                                   20


<210> 11958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGGGTTT

<400> 11958
gcatacacac ttgcagtgtt                                                   20


<210> 11959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCAGTTT

<400> 11959
ttactatatg cacttgaaaa                                                   20


<210> 11960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGTTT

<400> 11960
gtgcccccaa attttgctaa                                                   20


<210> 11961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAAGATT

<400> 11961
atttaaaaat gtgtatgtag                                                   20


<210> 11962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGTTT

<400> 11962
gatttatcag tagtattttt                                                   20


<210> 11963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAAGTTT

<400> 11963
ttcttttttt aaattatact                                                   20


<210> 11964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAAGCTT

<400> 11964
atgcatacat gccttacata                                                   20


<210> 11965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAGGCTT

<400> 11965
atatgaagct tttctcacta                                                   20


<210> 11966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCATGTTT

<400> 11966
aggcttggaa aataccttct                                                   20


<210> 11967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTAGTTT

<400> 11967
ccatgttttt ttctttcttt                                                   20


<210> 11968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGTTT

<400> 11968
ggtaaagagt aagatattga                                                   20


<210> 11969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGATT

<400> 11969
tgtggtttat tttttcctgt                                                   20


<210> 11970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAAGATT

<400> 11970
ttgaataatt tttcattttc                                                   20


<210> 11971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGTTT

<400> 11971
tgttattacc atttatgttc                                                   20


<210> 11972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGTTT

<400> 11972
actatttatt ttcactgtca                                                   20


<210> 11973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTGGATT

<400> 11973
tcatgctgtt ttaatcactg                                                   20


<210> 11974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCTGTTT

<400> 11974
ctgggaccaa aatcaacaat                                                   20


<210> 11975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTTGATT

<400> 11975
aacagccttg acattgttga                                                   20


<210> 11976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATTGATT

<400> 11976
gccttgacat tgttgaactt                                                   20


<210> 11977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCAGCTT

<400> 11977
gagactaaaa gtatctactt                                                   20


<210> 11978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTACGCTT

<400> 11978
actttcctcc cttcatcctg                                                   20


<210> 11979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGCTT

<400> 11979
cttttactcc attaatcctc                                                   20


<210> 11980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCATGTTT

<400> 11980
actaaagccc ctggaccttt                                                   20


<210> 11981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGCTT

<400> 11981
tcctctgctg ggtccatctc                                                   20


<210> 11982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGTTT

<400> 11982
ttctgcttaa ctattaaaca                                                   20


<210> 11983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACTGCTT

<400> 11983
aaaattacca cttacattca                                                   20


<210> 11984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGCTT

<400> 11984
tcaagcactg ccatcttgta                                                   20


<210> 11985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTGGTTT

<400> 11985
ttgtacttgg cttcctccta                                                   20


<210> 11986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGTTT

<400> 11986
ccatatcctt aatgcagtct                                                   20


<210> 11987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAGGCTT

<400> 11987
ttctctaggt tacagctaca                                                   20


<210> 11988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGCTT

<400> 11988
ccttcaaatg ttattctctc                                                   20


<210> 11989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCAGCTT

<400> 11989
cagtaagctc actgctgtga                                                   20


<210> 11990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGCTT

<400> 11990
tgtgacccag cttctggaat                                                   20


<210> 11991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGCTT

<400> 11991
ggcttggaca acagtgaaat                                                   20


<210> 11992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACATGCTT

<400> 11992
atgccaagca tagaaggttc                                                   20


<210> 11993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTGGTTT

<400> 11993
cagtgaattg tcaaactcct                                                   20


<210> 11994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAGGTTT

<400> 11994
ttgacctctt ttatttaacc                                                   20


<210> 11995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGATT

<400> 11995
ttaacctaag gtttcctctc                                                   20


<210> 11996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CATTGTTT

<400> 11996
tcagattttc tttaaaacat                                                   20


<210> 11997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CATAGATT

<400> 11997
aacagacaca tctccgccct                                                   20


<210> 11998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGCTT

<400> 11998
gccagtcgtg gttctaagca                                                   20


<210> 11999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGTTT

<400> 11999
tttgtcttac ctacactggg                                                   20


<210> 12000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGCTT

<400> 12000
ggatgtgttt gggacatgca                                                   20


<210> 12001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGCTT

<400> 12001
ttgtgtctgc gaactttctc                                                   20


<210> 12002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGATT

<400> 12002
ttctcctcag cttcttacat                                                   20


<210> 12003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTAGATT

<400> 12003
tgtccccttc cctgctagga                                                   20


<210> 12004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCAAGCTT

<400> 12004
aggatgtaga ttccatgagc                                                   20


<210> 12005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGCTT

<400> 12005
acacacaaca ggggctcaac                                                   20


<210> 12006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGCTT

<400> 12006
aatgaaagaa gagagaagga                                                   20


<210> 12007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACAGTTT

<400> 12007
aagagagaag gaggaagctt                                                   20


<210> 12008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACTGTTT

<400> 12008
gagaataaat gaaaaaaaca                                                   20


<210> 12009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAATGTTT

<400> 12009
aaaaacaaac tgtttgtatt                                                   20


<210> 12010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGTTT

<400> 12010
aactgtttgt attcaatgtt                                                   20


<210> 12011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCAGCTT

<400> 12011
aagaaagaaa ttgtgggaat                                                   20


<210> 12012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGCTT

<400> 12012
gtaacttagt tgaattcaat                                                   20


<210> 12013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGTTT

<400> 12013
ttcaatatct gagtctgtgt                                                   20


<210> 12014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGTTT

<400> 12014
atgaagatgg ctcttctctc                                                   20


<210> 12015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCTGCTT

<400> 12015
agccacaggg ctctctctga                                                   20


<210> 12016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCAGATT

<400> 12016
ctaagctaag gttgcctttc                                                   20


<210> 12017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGTTT

<400> 12017
ccagattttc ttaaaaacgt                                                   20


<210> 12018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCAGTTT

<400> 12018
tccttatttt cttccttttt                                                   20


<210> 12019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TACAGTTT

<400> 12019
attactggct agttctactc                                                   20


<210> 12020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAGGCTT

<400> 12020
tgtgcatgtg aatctctctc                                                   20


<210> 12021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGCTT

<400> 12021
tctctctaag gcttgccacc                                                   20


<210> 12022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGTTT

<400> 12022
gaaagtaggg cacacattgg                                                   20


<210> 12023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGTTT

<400> 12023
tgaaatccct caaacatttt                                                   20


<210> 12024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAGGATT

<400> 12024
caccacttct tcccctcaaa                                                   20


<210> 12025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCAGTTT

<400> 12025
ttacaactcc tccagcctag                                                   20


<210> 12026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTGGATT

<400> 12026
ataccctaag gcaaaaaaag                                                   20


<210> 12027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGCTT

<400> 12027
gccactctct tcctctaccc                                                   20


<210> 12028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTGGATT

<400> 12028
atacattgct ggggagactg                                                   20


<210> 12029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTTGATT

<400> 12029
gggagactga gtggattccc                                                   20


<210> 12030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GACTGATT

<400> 12030
aacaaggact tagttaaatt                                                   20


<210> 12031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGGGCTT

<400> 12031
ctaccaatat tcagcataat                                                   20


<210> 12032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGTTT

<400> 12032
tgccagatca cttttaaaaa                                                   20


<210> 12033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 12033
atattttatt catcaaatta                                                   20


<210> 12034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGACGCTT

<400> 12034
gaattccagt acacagagat                                                   20


<210> 12035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CATTGCTT

<400> 12035
gctttgacac gagttagaga                                                   20


<210> 12036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGTGATT

<400> 12036
gttctgacaa atacatcatt                                                   20


<210> 12037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGTTT

<400> 12037
aaacagttaa taaacataaa                                                   20


<210> 12038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGCTT

<400> 12038
ataaacataa agaaagttta                                                   20


<210> 12039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAGGCTT

<400> 12039
ctttttacaa ggggagataa                                                   20


<210> 12040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGTTT

<400> 12040
ggatgccttt gactttaagg                                                   20


<210> 12041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGTGATT

<400> 12041
ttgactttaa ggctctgttt                                                   20


<210> 12042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAGGTTT

<400> 12042
tccttaccct ctggttctgg                                                   20


<210> 12043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTGGCTT

<400> 12043
agacaagtca ggtattttcc                                                   20


<210> 12044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACAGCTT

<400> 12044
tcccttcagc ctaggcatgt                                                   20


<210> 12045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTAGTTT

<400> 12045
tgtaacagct tccccctgtt                                                   20


<210> 12046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGTTT

<400> 12046
ttagcccatc ggagtggtcc                                                   20


<210> 12047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGCGATT

<400> 12047
ccctgacttg ccattacact                                                   20


<210> 12048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGCTT

<400> 12048
tgtgagtaaa gcaaggaata                                                   20


<210> 12049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGTTT

<400> 12049
gtgccatttg cccagcctag                                                   20


<210> 12050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGTTT

<400> 12050
aagcaggaag agaagggtcc                                                   20


<210> 12051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCTGTTT

<400> 12051
actgcagaat aaaccaggaa                                                   20


<210> 12052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAGGCTT

<400> 12052
atcccttcca ttggtgatac                                                   20


<210> 12053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAGGCTT

<400> 12053
gatactcagg cttcttggct                                                   20


<210> 12054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGGGCTT

<400> 12054
agggttgctg ggttgaggaa                                                   20


<210> 12055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGCTT

<400> 12055
acccagcagc agagagcccc                                                   20


<210> 12056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CGGCGTTT

<400> 12056
acacactgcc atgactagcc                                                   20


<210> 12057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGATT

<400> 12057
cgggaaagac caggagagag                                                   20


<210> 12058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTTGATT

<400> 12058
ccttgtcacc tggatagttc                                                   20


<210> 12059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGTTT

<400> 12059
gatcccatct gtatgaatgt                                                   20


<210> 12060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGTTT

<400> 12060
gacaagagct gtacagtgca                                                   20


<210> 12061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CGAGGCTT

<400> 12061
aatgagtttc taggatccct                                                   20


<210> 12062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGCTT

<400> 12062
atcttccatt gagggaactg                                                   20


<210> 12063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TACCGATT

<400> 12063
ttcataccaa actctgatca                                                   20


<210> 12064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAAGTTT

<400> 12064
atccccttat ctcacagaac                                                   20


<210> 12065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCTGTTT

<400> 12065
cttgataatt tgaagcctga                                                   20


<210> 12066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAGGTTT

<400> 12066
gccacgagtt attttagaat                                                   20


<210> 12067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGCTT

<400> 12067
cttctgagta taagcattag                                                   20


<210> 12068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGATT

<400> 12068
ctctaacgag accaactggt                                                   20


<210> 12069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATGGCTT

<400> 12069
ttaatttcta ttggttataa                                                   20


<210> 12070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGATGTTT

<400> 12070
ctatccagcc ccataagagt                                                   20


<210> 12071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCTGATT

<400> 12071
cataagagtg gatgtttctt                                                   20


<210> 12072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGTTT

<400> 12072
atacactatt taacacatag                                                   20


<210> 12073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGATT

<400> 12073
cattgacatt tccatggaag                                                   20


<210> 12074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGATT

<400> 12074
aagctgtgat tcatcctgtt                                                   20


<210> 12075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGTTT

<400> 12075
cagtgtgcat gcaagtgtgt                                                   20


<210> 12076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCGGCTT

<400> 12076
tgcaaaaaag taaaatatcc                                                   20


<210> 12077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGATT

<400> 12077
ccttcggctt agcacaggaa                                                   20


<210> 12078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTGGATT

<400> 12078
ggtgctgaag ccattcccag                                                   20


<210> 12079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GACAGCTT

<400> 12079
cttttctgat aacaacaggt                                                   20


<210> 12080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAAGATT

<400> 12080
ctttgatgtc cgcagacacc                                                   20


<210> 12081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGGGCTT

<400> 12081
ttaagattgg catgttcagt                                                   20


<210> 12082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGATT

<400> 12082
tcatcttgga atcaccaccc                                                   20


<210> 12083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTAGTTT

<400> 12083
cccatctata attacacttt                                                   20


<210> 12084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGTGATT

<400> 12084
tggttgtaag gatcagagcg                                                   20


<210> 12085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGCTT

<400> 12085
ctgtggagcc ctctgacact                                                   20


<210> 12086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGCTT

<400> 12086
cagcaggtgt agccaatagt                                                   20


<210> 12087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGGGATT

<400> 12087
gggttaggac cagggtggtg                                                   20


<210> 12088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGCTT

<400> 12088
aggtcagcac agctatcccg                                                   20


<210> 12089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCTGCTT

<400> 12089
aaaaaaagtc tcttttggct                                                   20


<210> 12090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTTGTTT

<400> 12090
ggtctctagc tgagaacact                                                   20


<210> 12091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGTTT

<400> 12091
tagttccacc ctctgcccca                                                   20


<210> 12092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGCTT

<400> 12092
ccaccctctg ccccattctg                                                   20


<210> 12093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTCGCTT

<400> 12093
gccccattct gttttgcttc                                                   20


<210> 12094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTAGCTT

<400> 12094
cacttgcaca agaatcctca                                                   20


<210> 12095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGATGATT

<400> 12095
ctaatatggt ccctgaggca                                                   20


<210> 12096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGCTT

<400> 12096
acagtctgca accttcttca                                                   20


<210> 12097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGCTT

<400> 12097
gcctcctgga acttcttctc                                                   20


<210> 12098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGATT

<400> 12098
gaccaggtag aaagatccca                                                   20


<210> 12099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATAGATT

<400> 12099
tacgagcaca aaaaagatca                                                   20


<210> 12100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAAGTTT

<400> 12100
tagttaaaat ccgggttgtc                                                   20


<210> 12101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCTGCTT

<400> 12101
caagaacaga gaaggtcatc                                                   20


<210> 12102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGTTT

<400> 12102
ccagggctgc gagacaacca                                                   20


<210> 12103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGTTT

<400> 12103
aggatgatct tggacacttg                                                   20


<210> 12104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTGGTTT

<400> 12104
gacacttggt ctgtttaggt                                                   20


<210> 12105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGATT

<400> 12105
ggtctcacat tagccaagtt                                                   20


<210> 12106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGTGCTT

<400> 12106
gtgttcttct ctctcccttt                                                   20


<210> 12107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCAGATT

<400> 12107
aagatggcct atgaaggaag                                                   20


<210> 12108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTCGTTT

<400> 12108
tgatcaatga aacagcaatg                                                   20


<210> 12109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCTGTTT

<400> 12109
tttaaatttt tttctttttc                                                   20


<210> 12110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAGGATT

<400> 12110
tacatggaat tcttttactc                                                   20


<210> 12111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CATGGATT

<400> 12111
tccatgtgaa caacccatac                                                   20


<210> 12112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTCGATT

<400> 12112
cagttccaag tctatctcca                                                   20


<210> 12113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAAGATT

<400> 12113
aagtctatct ccacttcgat                                                   20


<210> 12114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTGGCTT

<400> 12114
cgattgaaga ttgcaagttc                                                   20


<210> 12115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGTTT

<400> 12115
cccacattta aagataggct                                                   20


<210> 12116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTAGGTTT

<400> 12116
ggctaggcaa cccatttcct                                                   20


<210> 12117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTTGTTT

<400> 12117
ttaattaact ctgagggcag                                                   20


<210> 12118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAGGATT

<400> 12118
atataaacag ttcactgctc                                                   20


<210> 12119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATTGTTT

<400> 12119
aaactgcaaa ggaaaattcc                                                   20


<210> 12120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGCTT

<400> 12120
tgtgggcctt tcctcaggac                                                   20


<210> 12121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAGGTTT

<400> 12121
tctgcagccc cacagaggac                                                   20


<210> 12122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGCTT

<400> 12122
agccccacag aggacccagg                                                   20


<210> 12123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGTTT

<400> 12123
cagaaggatg ctgaggggct                                                   20


<210> 12124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCTGCTT

<400> 12124
acctgatgtt gaccaaatgc                                                   20


<210> 12125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTTGTTT

<400> 12125
gatgttgacc aaatgctcct                                                   20


<210> 12126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATAGTTT

<400> 12126
cagtcctcag ctccaactga                                                   20


<210> 12127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGCTT

<400> 12127
ggcactgggg gtgttgtgag                                                   20


<210> 12128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTAGCTT

<400> 12128
gagctgaggg gtcctcatcc                                                   20


<210> 12129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGTTT

<400> 12129
tgcctcacac cgccacctca                                                   20


<210> 12130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTTGTTT

<400> 12130
tatgaagcct ctagtaaaga                                                   20


<210> 12131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCAGCTT

<400> 12131
tgaatgagaa attgcaaact                                                   20


<210> 12132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTGGATT

<400> 12132
tgcaaactag cagcttatag                                                   20


<210> 12133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 12133
ggatttggcc cacagaaata                                                   20


<210> 12134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAATGTTT

<400> 12134
cattttttgg aataggtagc                                                   20


<210> 12135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGAGATT

<400> 12135
ggtagccaat gtttacggtt                                                   20


<210> 12136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGTTT

<400> 12136
gaaattgcaa agtctgatac                                                   20


<210> 12137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGATT

<400> 12137
ctatagaatg gagttagctg                                                   20


<210> 12138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTAGATT

<400> 12138
aagtattggt tccttcctgg                                                   20


<210> 12139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTTGCTT

<400> 12139
tggatctcta ctggactgca                                                   20


<210> 12140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGTTT

<400> 12140
gaagaagcct tgcaaacttc                                                   20


<210> 12141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCTGTTT

<400> 12141
atgagaacag gcccaggcta                                                   20


<210> 12142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTTGTTT

<400> 12142
gaatcatgaa ttaaatacat                                                   20


<210> 12143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCATGATT

<400> 12143
gagctctggg ttggcaaagg                                                   20


<210> 12144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCGTGCTT

<400> 12144
gagaaggaat tgttgggcac                                                   20


<210> 12145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTCGCTT

<400> 12145
acagtaaggg gtcagaagtg                                                   20


<210> 12146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGATT

<400> 12146
cagaggtaga atgacttgcc                                                   20


<210> 12147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCACGTTT

<400> 12147
ccctatggaa gagactccac                                                   20


<210> 12148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCAGTTT

<400> 12148
tggtgaggat ggtcacatca                                                   20


<210> 12149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CGAAGCTT

<400> 12149
gttccaagac ctttctcatc                                                   20


<210> 12150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCAGCTT

<400> 12150
ctttctgcat gcatctggga                                                   20


<210> 12151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGAGTTT

<400> 12151
agacacagag aaacagagag                                                   20


<210> 12152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCTGCTT

<400> 12152
ctggcagcaa agaaggatac                                                   20


<210> 12153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTTGTTT

<400> 12153
cagcaaagaa ggatacacct                                                   20


<210> 12154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGATGATT

<400> 12154
acacctgctt gtttaaggag                                                   20


<210> 12155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCAGCTT

<400> 12155
aaaatcaact tctttgggag                                                   20


<210> 12156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTAGGATT

<400> 12156
gctctgacca gggaagcaat                                                   20


<210> 12157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTGGATT

<400> 12157
ggagtatttg cagaaccgta                                                   20


<210> 12158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGTTT

<400> 12158
gtgtccagtg ggaattggca                                                   20


<210> 12159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGTGTTT

<400> 12159
aaagacttcc actctagaat                                                   20


<210> 12160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGTTT

<400> 12160
ttccactcta gaatgggtgt                                                   20


<210> 12161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGTTT

<400> 12161
aagcatcaag tcccatttca                                                   20


<210> 12162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGCTT

<400> 12162
gatcttagag gccccacaca                                                   20


<210> 12163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 12163
aatgagcttt gatggactac                                                   20


<210> 12164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAGGATT

<400> 12164
tttcctctgg gtgtctaaag                                                   20


<210> 12165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GACTGCTT

<400> 12165
ggaaacagtg aagatactgg                                                   20


<210> 12166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAAGTTT

<400> 12166
ttctcccttc ctccccattt                                                   20


<210> 12167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGTTT

<400> 12167
cccatttcca agtttaatcc                                                   20


<210> 12168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATTGATT

<400> 12168
gacatgcccc tcctgttacg                                                   20


<210> 12169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAGGCTT

<400> 12169
ctggcctagg agttgggaca                                                   20


<210> 12170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGGGTTT

<400> 12170
ctcttactag tgaagaggcc                                                   20


<210> 12171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGTTT

<400> 12171
ctagtgaaga ggccttgggt                                                   20


<210> 12172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACTGTTT

<400> 12172
tgctcacctg ggatcacaga                                                   20


<210> 12173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGATT

<400> 12173
catctataga ctgacactga                                                   20


<210> 12174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGTTT

<400> 12174
gtggacggat cttcaaacac                                                   20


<210> 12175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGATT

<400> 12175
gaccaaccag tctcctcaga                                                   20


<210> 12176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGATT

<400> 12176
tgtgacaggc taactgttat                                                   20


<210> 12177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATAGTTT

<400> 12177
tttttatttt attttatttc                                                   20


<210> 12178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTGGTTT

<400> 12178
tcaatagttt tgagggaaca                                                   20


<210> 12179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATAGTTT

<400> 12179
aagttcttta tttgtatttc                                                   20


<210> 12180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CGCTGATT

<400> 12180
tgcacagaaa aattctttaa                                                   20


<210> 12181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGATT

<400> 12181
aaattcttta acgctgattt                                                   20


<210> 12182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACAGCTT

<400> 12182
ttgttatgcc tttgcatcct                                                   20


<210> 12183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCTGCTT

<400> 12183
ttgcatcctc acagcttagc                                                   20


<210> 12184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGCTT

<400> 12184
tgcttgtaat taagaacaca                                                   20


<210> 12185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGCTT

<400> 12185
aataatagtc tccaactcca                                                   20


<210> 12186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATGGCTT

<400> 12186
tatgcaagtg tctttttaat                                                   20


<210> 12187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGGGATT

<400> 12187
ctctgggtag atacccagta                                                   20


<210> 12188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAACGTTT

<400> 12188
agttctttaa ggaatctcca                                                   20


<210> 12189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTAGTTT

<400> 12189
acgttttcct tagtggttgt                                                   20


<210> 12190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGTTT

<400> 12190
cattcccacc agcagtgtaa                                                   20


<210> 12191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGTTT

<400> 12191
ggagtaaggt ggtatctcat                                                   20


<210> 12192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGGGATT

<400> 12192
tgtcctttgc ccacttttgg                                                   20


<210> 12193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGTTT

<400> 12193
gcccactttt ggatgggatt                                                   20


<210> 12194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTTGTTT

<400> 12194
acttttggat gggattattt                                                   20


<210> 12195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGATT

<400> 12195
ggattatttg tttgttttct                                                   20


<210> 12196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGTGTTT

<400> 12196
ttgttttctt gctgatttat                                                   20


<210> 12197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGATT

<400> 12197
tttgctggaa gcatagataa                                                   20


<210> 12198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGTTT

<400> 12198
tttctctcat cctatgggtt                                                   20


<210> 12199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGATGATT

<400> 12199
tatgggttgt ctgtttactt                                                   20


<210> 12200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACAGCTT

<400> 12200
gattatttct cttgctgtgc                                                   20


<210> 12201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGTTT

<400> 12201
ctcttgctgt gcaacagctt                                                   20


<210> 12202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 12202
attagatccc atctatttat                                                   20


<210> 12203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTGGATT

<400> 12203
atctatttat ttttgttttt                                                   20


<210> 12204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGCTT

<400> 12204
tttatttttg tttttgttgg                                                   20


<210> 12205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAACGTTT

<400> 12205
tgctttgggt ccttggtcag                                                   20


<210> 12206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGTTT

<400> 12206
ttgcctaagc caatgtctag                                                   20


<210> 12207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTAGATT

<400> 12207
aattttttat aatttcaggt                                                   20


<210> 12208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGATT

<400> 12208
taagcctttt atccatcttg                                                   20


<210> 12209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAAGATT

<400> 12209
tttttgtata aggtgagaga                                                   20


<210> 12210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGTTT

<400> 12210
tataaggtga gagatgaaga                                                   20


<210> 12211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGCTT

<400> 12211
ttcagtttct ttcttccaca                                                   20


<210> 12212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTACGTTT

<400> 12212
atagggtgtc ctttccccac                                                   20


<210> 12213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 12213
tgtcctttcc ccacttacgt                                                   20


<210> 12214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTTGCTT

<400> 12214
ctttccccac ttacgttttt                                                   20


<210> 12215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTTGCTT

<400> 12215
tgtttgcttt ttcaaagatc                                                   20


<210> 12216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGCTT

<400> 12216
agatcagttg cttgtaagta                                                   20


<210> 12217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGCTT

<400> 12217
ctattctttt ccattggtct                                                   20


<210> 12218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGTTT

<400> 12218
ttatttttat accagtatca                                                   20


<210> 12219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATAGTTT

<400> 12219
gctatactat agccttgtag                                                   20


<210> 12220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGATT

<400> 12220
aaatcagcta aggtgatgcc                                                   20


<210> 12221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGCTT

<400> 12221
gatgcctcca gatttgttat                                                   20


<210> 12222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGCTT

<400> 12222
gatttgttat tcttgcttag                                                   20


<210> 12223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGATT

<400> 12223
gcttagtctt gctttggcta                                                   20


<210> 12224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATTGCTT

<400> 12224
gaaattgtat tgaatctgta                                                   20


<210> 12225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATTGATT

<400> 12225
cagtaaggtc attttcacaa                                                   20


<210> 12226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGTTT

<400> 12226
tgagcatggg atgtgttccc                                                   20


<210> 12227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGATT

<400> 12227
ttcccatttg tttgtgtcat                                                   20


<210> 12228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGTTT

<400> 12228
tcatctgtga tttattttag                                                   20


<210> 12229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTAGTTT

<400> 12229
gatttatttt agcagtgttt                                                   20


<210> 12230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTAAGATT

<400> 12230
ctttttggtt aggtatattc                                                   20


<210> 12231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 12231
taggtatatt cctaagattt                                                   20


<210> 12232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 12232
taagattttt ttgtttttat                                                   20


<210> 12233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGGGATT

<400> 12233
tttttttgca gctgttgtaa                                                   20


<210> 12234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGATT

<400> 12234
tgttgtaaaa gggattgagt                                                   20


<210> 12235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGCTT

<400> 12235
attgagttct tgatttgttc                                                   20


<210> 12236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGTTT

<400> 12236
gttcttgatt tgttcctcag                                                   20


<210> 12237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGATT

<400> 12237
ctggtggtgt acagtagtgc                                                   20


<210> 12238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CATTGTTT

<400> 12238
tagtgctgct gatttgtata                                                   20


<210> 12239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGCTT

<400> 12239
tgaattcatt tattagatct                                                   20


<210> 12240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGGGTTT

<400> 12240
gagctttttg gatgagtctt                                                   20


<210> 12241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACAGTTT

<400> 12241
tcatatcatt ggtgaacagc                                                   20


<210> 12242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TACTGATT

<400> 12242
caacagtttg acttcccctt                                                   20


<210> 12243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGATT

<400> 12243
tttgacttcc cctttactga                                                   20


<210> 12244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGATT

<400> 12244
tccctttatt tatttctctt                                                   20


<210> 12245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGTTT

<400> 12245
ggtgaaagtg ggcatccttg                                                   20


<210> 12246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAATGCTT

<400> 12246
cttgtttcag ttctcagggg                                                   20


<210> 12247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCTGTTT

<400> 12247
ggggaatgct ttcaactttt                                                   20


<210> 12248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGATT

<400> 12248
ctgtttggta taatgttggc                                                   20


<210> 12249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGCTT

<400> 12249
ttggctgtgg atttgtcata                                                   20


<210> 12250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGGGTTT

<400> 12250
ccttctatgc caatttggtt                                                   20


<210> 12251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTGGATT

<400> 12251
ggttttaatc ataatgggat                                                   20


<210> 12252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGCTT

<400> 12252
atgggatgct ggattttgtc                                                   20


<210> 12253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATATGATT

<400> 12253
ctgcacctat tgagatgatc                                                   20


<210> 12254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 12254
tattgagatg atcatatgat                                                   20


<210> 12255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGTTT

<400> 12255
catatgattt ttgtttttaa                                                   20


<210> 12256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTGGATT

<400> 12256
gtgttatctt ttggatatgt                                                   20


<210> 12257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAGGATT

<400> 12257
tcaattagct agcattttgt                                                   20


<210> 12258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGTTT

<400> 12258
ttctttttta aaagtccttt                                                   20


<210> 12259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTGGCTT

<400> 12259
ggttttggta ttagggtgat                                                   20


<210> 12260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGATT

<400> 12260
agggtgatac tggcttcata                                                   20


<210> 12261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAGGATT

<400> 12261
tggcttcata aaatgattta                                                   20


<210> 12262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATAGTTT

<400> 12262
cctctttctg catcttttgg                                                   20


<210> 12263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TACTGTTT

<400> 12263
ttccttggca atttttgaat                                                   20


<210> 12264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGTTT

<400> 12264
aatctcgcta cttgttattg                                                   20


<210> 12265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGAGTTT

<400> 12265
ctacttgtta ttggtctgtt                                                   20


<210> 12266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGATT

<400> 12266
tgtttagagt ttctattact                                                   20


<210> 12267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGTTT

<400> 12267
tattcatctc ctctaaattt                                                   20


<210> 12268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAATGATT

<400> 12268
aaggtgttca tagtagcctt                                                   20


<210> 12269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGAGCTT

<400> 12269
atctcccatt ttatttctaa                                                   20


<210> 12270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCCGCTT

<400> 12270
tttctatatc tttttaaaga                                                   20


<210> 12271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 12271
atctttttaa agaacccgct                                                   20


<210> 12272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGCTT

<400> 12272
gatctttgtt attccttttc                                                   20


<210> 12273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGTTT

<400> 12273
ttgttattcc ttttcttctg                                                   20


<210> 12274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGTTT

<400> 12274
ttttcttctg cttggtttgg                                                   20


<210> 12275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGTTT

<400> 12275
ttggtttggg tctgttttgt                                                   20


<210> 12276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTAGATT

<400> 12276
ctaattcctt gaggtgtgac                                                   20


<210> 12277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGCTT

<400> 12277
tgatgtaggt atttaatgct                                                   20


<210> 12278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGCTT

<400> 12278
gctatgagct ttcctcttag                                                   20


<210> 12279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAGGTTT

<400> 12279
cactgcttta gctgtatccc                                                   20


<210> 12280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGATT

<400> 12280
aaaaaatttt taaacttcca                                                   20


<210> 12281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCAGATT

<400> 12281
tgacccaaag atcattcaag                                                   20


<210> 12282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATTGTTT

<400> 12282
ccaaagatca ttcaagagca                                                   20


<210> 12283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGTTT

<400> 12283
gatcattcaa gagcagattg                                                   20


<210> 12284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATAGTTT

<400> 12284
gtttagtttt catgtatttg                                                   20


<210> 12285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGGGTTT

<400> 12285
tcatgtattt gtatagtttt                                                   20


<210> 12286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CGAGGTTT

<400> 12286
gtttcttttg gagttaactc                                                   20


<210> 12287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGAGATT

<400> 12287
tttctatttt cttaaattta                                                   20


<210> 12288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTTGTTT

<400> 12288
gaaaagaatg tatattctgc                                                   20


<210> 12289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAATGTTT

<400> 12289
tattctgcag ttgtttggta                                                   20


<210> 12290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TACAGTTT

<400> 12290
taagtccatt tgttctaggt                                                   20


<210> 12291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CATTGTTT

<400> 12291
tctaggttac agtttaagtt                                                   20


<210> 12292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGTTT

<400> 12292
catttcttag gtctagtagt                                                   20


<210> 12293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAGGATT

<400> 12293
agtgttaggt gcatatgtat                                                   20


<210> 12294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTTGCTT

<400> 12294
ctttgtcttt ttttaactgt                                                   20


<210> 12295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGTTT

<400> 12295
ttaactgttg ttgctttaag                                                   20


<210> 12296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCTGCTT

<400> 12296
tctgatataa gaatagctac                                                   20


<210> 12297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTTGCTT

<400> 12297
atataagaat agctactcct                                                   20


<210> 12298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGTTT

<400> 12298
aatagctact cctgcttgct                                                   20


<210> 12299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAAGTTT

<400> 12299
tcttttccca tctctttacc                                                   20


<210> 12300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTGGATT

<400> 12300
aagacagtag atacttggtt                                                   20


<210> 12301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATTGTTT

<400> 12301
aattcctttt tttattgtgt                                                   20


<210> 12302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGCTT

<400> 12302
ttttataggt cctttgatat                                                   20


<210> 12303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAGGTTT

<400> 12303
ggttctattt tggtgtattt                                                   20


<210> 12304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAAGATT

<400> 12304
gtgtatttta aggttttatt                                                   20


<210> 12305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTGGCTT

<400> 12305
cttttagcat ttcttgtagt                                                   20


<210> 12306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGTTT

<400> 12306
tagtggaaaa ttctctcacc                                                   20


<210> 12307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAAGCTT

<400> 12307
ctttatcttg tcttcactta                                                   20


<210> 12308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTAGTTT

<400> 12308
tcttgtcttc acttatgaag                                                   20


<210> 12309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 12309
atattcttgg ctggcaatta                                                   20


<210> 12310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGCTT

<400> 12310
aagatgggac cctaatccct                                                   20


<210> 12311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAGGTTT

<400> 12311
ccctaatccc ttctggcttg                                                   20


<210> 12312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAGGCTT

<400> 12312
cctttccttt ataggttatc                                                   20


<210> 12313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAAGATT

<400> 12313
aggcttttgt ctcacagctc                                                   20


<210> 12314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGAGCTT

<400> 12314
acacatttca gaggtattct                                                   20


<210> 12315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGTTT

<400> 12315
tatatttcta acaaggccag                                                   20


<210> 12316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAAGTTT

<400> 12316
ttcctcaatt attccctcaa                                                   20


<210> 12317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGATT

<400> 12317
tcaaataagt tttccaaact                                                   20


<210> 12318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAGGTTT

<400> 12318
cttgggaaca cccattattc                                                   20


<210> 12319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTTGTTT

<400> 12319
cacccattat tcttaggttt                                                   20


<210> 12320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACATGATT

<400> 12320
ttcttaggtt tggttgtttc                                                   20


<210> 12321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCCGATT

<400> 12321
cacatgattc caaatttatt                                                   20


<210> 12322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTAGTTT

<400> 12322
aattctttct ttttgtgtgt                                                   20


<210> 12323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGCTT

<400> 12323
tgtcttagtt tgggtctatt                                                   20


<210> 12324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGTGATT

<400> 12324
gagtcttcca tttccagaag                                                   20


<210> 12325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATTGTTT

<400> 12325
cttccatttc cagaagttgt                                                   20


<210> 12326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTTGTTT

<400> 12326
agaattttcc atccatatct                                                   20


<210> 12327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTGGTTT

<400> 12327
tgttttaaaa atttctttaa                                                   20


<210> 12328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGATT

<400> 12328
tctttttttt ttttttttga                                                   20


<210> 12329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGATT

<400> 12329
tgcctcagtc tcctgagtag                                                   20


<210> 12330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CGGGGTTT

<400> 12330
tttgtatttt ttagtagaga                                                   20


<210> 12331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTGGCTT

<400> 12331
tagagacggg gtttctccat                                                   20


<210> 12332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGATT

<400> 12332
caccttggcc tcccaaagtg                                                   20


<210> 12333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGAGATT

<400> 12333
gaattcttta tctggcaatt                                                   20


<210> 12334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTAGTTT

<400> 12334
tggcaattca gagatttctt                                                   20


<210> 12335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTAGTTT

<400> 12335
tttggatcca ttgttgggga                                                   20


<210> 12336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGCTT

<400> 12336
ctcttttgtc atattaccag                                                   20


<210> 12337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGATT

<400> 12337
ctggaactga atggctgttg                                                   20


<210> 12338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 12338
aatggctgtt gtgcagattc                                                   20


<210> 12339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGGGCTT

<400> 12339
tctccccaat cccctgggga                                                   20


<210> 12340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGATT

<400> 12340
atgcctgcaa gagtcctgtg                                                   20


<210> 12341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATAGATT

<400> 12341
tgtgagagtc ctaggctgta                                                   20


<210> 12342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTGGCTT

<400> 12342
gctgtagata gatttagtgt                                                   20


<210> 12343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTTGTTT

<400> 12343
ttgcaggcag tgcaactggt                                                   20


<210> 12344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTTGCTT

<400> 12344
atcaaagtta ttctgtcatg                                                   20


<210> 12345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGTTT

<400> 12345
tgagttgctt taatggcctg                                                   20


<210> 12346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGCTT

<400> 12346
tttgacctcc agccggtagg                                                   20


<210> 12347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGTTT

<400> 12347
aagttggcca gggtaaatat                                                   20


<210> 12348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGCTT

<400> 12348
ttaggtgatg agcagggcca                                                   20


<210> 12349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGTTT

<400> 12349
agcagggcca taaagcttcc                                                   20


<210> 12350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGTTT

<400> 12350
cataaagctt ccgagagttt                                                   20


<210> 12351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGGGATT

<400> 12351
agactcagac ccttcttggg                                                   20


<210> 12352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGAGCTT

<400> 12352
ctcagacctt gccccaggct                                                   20


<210> 12353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGCTT

<400> 12353
tttggaccgc atccctcact                                                   20


<210> 12354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTGGATT

<400> 12354
cttgcagttc ccatttgccc                                                   20


<210> 12355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCTGATT

<400> 12355
tctttcatcc tgtgacccct                                                   20


<210> 12356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGATT

<400> 12356
gcctgtgaga catagtcagg                                                   20


<210> 12357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGTTT

<400> 12357
gcctacaagg cacttccctt                                                   20


<210> 12358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGCTT

<400> 12358
gtttctactt ttatattttg                                                   20


<210> 12359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGATT

<400> 12359
ggtaaattct tctcctgtga                                                   20


<210> 12360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGATT

<400> 12360
cttctcctgt gatctggatt                                                   20


<210> 12361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTATGTTT

<400> 12361
tcagattacc cagttgggat                                                   20


<210> 12362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCAGGTTT

<400> 12362
gttgggatgt atgtttggag                                                   20


<210> 12363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACAGTTT

<400> 12363
cccctcacac tttgggagct                                                   20


<210> 12364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAGGCTT

<400> 12364
cctcttgcca gtatctttat                                                   20


<210> 12365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCAGCTT

<400> 12365
tgtgtgtggc tgggacagcc                                                   20


<210> 12366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAGGATT

<400> 12366
gggcagtagc gggtgaagag                                                   20


<210> 12367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCTGTTT

<400> 12367
cgggtgaaga gcaaggattc                                                   20


<210> 12368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCAGTTT

<400> 12368
tggaggctca tctaaaaact                                                   20


<210> 12369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACTGCTT

<400> 12369
gctatgctgc agagccccag                                                   20


<210> 12370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAGGTTT

<400> 12370
atgctaagta tctctgaaag                                                   20


<210> 12371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGCTT

<400> 12371
gtgataagta gggctgaaag                                                   20


<210> 12372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGTTT

<400> 12372
tagggctgaa agaattgctt                                                   20


<210> 12373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGAGCTT

<400> 12373
aagtttttta caggaaccag                                                   20


<210> 12374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGCTT

<400> 12374
aaccagttga gctttctaga                                                   20


<210> 12375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACTGTTT

<400> 12375
atgccatcca ttcaatgaga                                                   20


<210> 12376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATGGATT

<400> 12376
gaaactgttt ctgctccaga                                                   20


<210> 12377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGTTT

<400> 12377
actgaaaaat gcatataaag                                                   20


<210> 12378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAAGTTT

<400> 12378
ctattcactt ctgctcctcg                                                   20


<210> 12379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGTTT

<400> 12379
gttaagtttc cagaagataa                                                   20


<210> 12380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGATGCTT

<400> 12380
aggagcatca ggaatttgaa                                                   20


<210> 12381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCAGATT

<400> 12381
cactttggga ggccgaggcg                                                   20


<210> 12382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CGGAGCTT

<400> 12382
aatggcgtga acccgggagg                                                   20


<210> 12383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGTTT

<400> 12383
ctaataggcg gacttgtaaa                                                   20


<210> 12384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGTTT

<400> 12384
gaaatggata ggaagtgata                                                   20


<210> 12385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATTGTTT

<400> 12385
gagaatcaga ctaggaggta                                                   20


<210> 12386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGTTT

<400> 12386
caggaggatc acttgaaccc                                                   20


<210> 12387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGATT

<400> 12387
cagaagatga agtactctag                                                   20


<210> 12388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGTTT

<400> 12388
caacaattaa acatctggag                                                   20


<210> 12389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGTTT

<400> 12389
ctgcatgaca cagctgtaaa                                                   20


<210> 12390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAAGATT

<400> 12390
atattatctg atgatctaac                                                   20


<210> 12391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGTTT

<400> 12391
gaagatgagg gtgagaggaa                                                   20


<210> 12392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAAGTTT

<400> 12392
atgagtttgt ggatgtggcc                                                   20


<210> 12393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGTTT

<400> 12393
agagatgaga aaaatgaaat                                                   20


<210> 12394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCGTGTTT

<400> 12394
cacatctgtg agaggagaaa                                                   20


<210> 12395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGCTT

<400> 12395
gaatctatat ctggttgcat                                                   20


<210> 12396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCAGCTT

<400> 12396
gttgcatagc tgcttgagct                                                   20


<210> 12397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTGGTTT

<400> 12397
gctgtcagct tccatatctt                                                   20


<210> 12398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGTTT

<400> 12398
tggtttcccc cccacactct                                                   20


<210> 12399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGCTT

<400> 12399
ctcagaatta taggttgttg                                                   20


<210> 12400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGTTT

<400> 12400
gggaagcttt gatggatatt                                                   20


<210> 12401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGCTT

<400> 12401
tgctctctaa agactatttt                                                   20


<210> 12402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGTGCTT

<400> 12402
agcccaatgt gttatttcct                                                   20


<210> 12403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGATT

<400> 12403
gagccacttg caccactgat                                                   20


<210> 12404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGATT

<400> 12404
cgatattcag gctctgaaaa                                                   20


<210> 12405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCAGTTT

<400> 12405
atgtacacta agtgaccaca                                                   20


<210> 12406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGAGTTT

<400> 12406
ttccttgctg accatgtggc                                                   20


<210> 12407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGTTT

<400> 12407
acacctttcc tcttttaaaa                                                   20


<210> 12408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGTTT

<400> 12408
attgtggaac tatcaccact                                                   20


<210> 12409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGCGTTT

<400> 12409
atcatgcaac atttgttctt                                                   20


<210> 12410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAATGCTT

<400> 12410
ttgagttatt ttacttagca                                                   20


<210> 12411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGTTT

<400> 12411
tttaaaactg aatgatattc                                                   20


<210> 12412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGTTT

<400> 12412
aagccaacat accttttaaa                                                   20


<210> 12413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTAGCTT

<400> 12413
cagagagctc ttcttttaaa                                                   20


<210> 12414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CATAGTTT

<400> 12414
atgctgacaa cttacttatt                                                   20


<210> 12415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGTTT

<400> 12415
tctaattaag gaattatacc                                                   20


<210> 12416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGTTT

<400> 12416
ggaattatac caattgtttt                                                   20


<210> 12417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGATT

<400> 12417
tctccaacca caatatttgt                                                   20


<210> 12418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTGGTTT

<400> 12418
tatttgtaat tgatttggaa                                                   20


<210> 12419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGTGCTT

<400> 12419
tcttaccagc aggagtgcaa                                                   20


<210> 12420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATAGTTT

<400> 12420
atgaggatga atgatgactc                                                   20


<210> 12421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGTGCTT

<400> 12421
tatactggga aagccttatt                                                   20


<210> 12422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTGGTTT

<400> 12422
gcttgtagta gagatattca                                                   20


<210> 12423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGAAGTTT

<400> 12423
actttattgg aaaataatat                                                   20


<210> 12424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATAGCTT

<400> 12424
gaaaataata tggaagtttt                                                   20


<210> 12425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGTTT

<400> 12425
cattttctta tatatttttg                                                   20


<210> 12426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGAGATT

<400> 12426
atatattttt gtctggtttt                                                   20


<210> 12427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACAGATT

<400> 12427
tatccacttg tctcatgaca                                                   20


<210> 12428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCATGCTT

<400> 12428
ttgtctcatg acaaacagat                                                   20


<210> 12429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTAGGATT

<400> 12429
ttgtgacctt atttcacatt                                                   20


<210> 12430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGCTT

<400> 12430
ttctattttt atcattattg                                                   20


<210> 12431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTATGATT

<400> 12431
cattagtcaa gataaactgc                                                   20


<210> 12432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCAGTTT

<400> 12432
tgttaaccat tatgaatgaa                                                   20


<210> 12433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGTTT

<400> 12433
atcagttttt gaagcacata                                                   20


<210> 12434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTAGATT

<400> 12434
tataataatt aatcttacat                                                   20


<210> 12435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GACAGTTT

<400> 12435
gagttggaac atcccaaagg                                                   20


<210> 12436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAAGATT

<400> 12436
ccaaagggac agtttatgaa                                                   20


<210> 12437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTAGTTT

<400> 12437
aaaaatagac taacaaacct                                                   20


<210> 12438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TACAGATT

<400> 12438
gactaacaaa cctgttagtt                                                   20


<210> 12439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CATAGCTT

<400> 12439
aaaataaata tgctcactgt                                                   20


<210> 12440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAAGTTT

<400> 12440
taagaatcat aaaggaagaa                                                   20


<210> 12441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GACAGTTT

<400> 12441
atagaaatta ataatattaa                                                   20


<210> 12442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAGGCTT

<400> 12442
tctgccatac tgatgtgtgg                                                   20


<210> 12443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGCGATT

<400> 12443
aaggcttcgt attgtaaatg                                                   20


<210> 12444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGTTT

<400> 12444
caattcagtg cattaccaaa                                                   20


<210> 12445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGATT

<400> 12445
tgttgactca ggatgtgaca                                                   20


<210> 12446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACAGATT

<400> 12446
acaatgagat tactgggaga                                                   20


<210> 12447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGATT

<400> 12447
cacatacaaa aataaattct                                                   20


<210> 12448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCCGTTT

<400> 12448
gcagtgttaa acacccactt                                                   20


<210> 12449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTAGATT

<400> 12449
acacccactt ccccgtttgc                                                   20


<210> 12450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGCTT

<400> 12450
acttccccgt ttgcagtaga                                                   20


<210> 12451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGTTT

<400> 12451
ccaaattgct ataatttgtc                                                   20


<210> 12452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGCTT

<400> 12452
aaaggttttc cagaatattg                                                   20


<210> 12453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAATGATT

<400> 12453
gggtcatcaa agagcccctt                                                   20


<210> 12454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGTTT

<400> 12454
gcccaatctg aggaagaacc                                                   20


<210> 12455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGGGATT

<400> 12455
agtttcttcc caagcaaaag                                                   20


<210> 12456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAATGTTT

<400> 12456
agcaggtaat tgtgcaaagc                                                   20


<210> 12457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGATT

<400> 12457
gaagggaggg aagataagga                                                   20


<210> 12458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAAGATT

<400> 12458
attgtgttaa gaacatggca                                                   20


<210> 12459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTGGTTT

<400> 12459
gttaagaaca tggcaataag                                                   20


<210> 12460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGATT

<400> 12460
aacatggcaa taagattggt                                                   20


<210> 12461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAATGCTT

<400> 12461
attcctcact ggctacaatt                                                   20


<210> 12462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGATT

<400> 12462
catttcaaaa agaaaatcta                                                   20


<210> 12463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCAGGATT

<400> 12463
aatacctgtc acataaattc                                                   20


<210> 12464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTAGATT

<400> 12464
cccaggattg tgaccatata                                                   20


<210> 12465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATGGATT

<400> 12465
taatacaaaa tctcctaaag                                                   20


<210> 12466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGACGATT

<400> 12466
ggaaaggatc caactttgga                                                   20


<210> 12467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAGGATT

<400> 12467
taatatgtgg tggcaaaata                                                   20


<210> 12468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGATT

<400> 12468
tttctataaa acagctgctg                                                   20


<210> 12469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGATT

<400> 12469
tgcatatttt tacaacagca                                                   20


<210> 12470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TACTGTTT

<400> 12470
gcatttggat ttattagatc                                                   20


<210> 12471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATTGCTT

<400> 12471
tgtttttcta ttttgtaatt                                                   20


<210> 12472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGTTT

<400> 12472
ctttcatttg ttatcctttt                                                   20


<210> 12473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCAGCTT

<400> 12473
aggtctttaa ataatttctt                                                   20


<210> 12474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTATGCTT

<400> 12474
cttttactga tataaatatt                                                   20


<210> 12475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGATT

<400> 12475
ctttaactgc actctctagg                                                   20


<210> 12476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACTGTTT

<400> 12476
cactctctag gttctgatta                                                   20


<210> 12477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGTTT

<400> 12477
ttccctcgaa attatataat                                                   20


<210> 12478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATAGTTT

<400> 12478
gaaattatat aattttagtt                                                   20


<210> 12479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGATT

<400> 12479
tttgtccaag aattctttaa                                                   20


<210> 12480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAATGTTT

<400> 12480
tctatttcat tatgatcaga                                                   20


<210> 12481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGAGCTT

<400> 12481
tctatattat ttccactttc                                                   20


<210> 12482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAGGTTT

<400> 12482
ttccactttc tggagcttat                                                   20


<210> 12483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CATGGCTT

<400> 12483
gagcttattg aggtttttgt                                                   20


<210> 12484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGTTT

<400> 12484
gtttttgtca tggcttaata                                                   20


<210> 12485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATATGTTT

<400> 12485
atggcttaat atttggtttg                                                   20


<210> 12486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGTTT

<400> 12486
ttaatatttg gtttgatatg                                                   20


<210> 12487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTAGTTT

<400> 12487
cattttctat tgttagggaa                                                   20


<210> 12488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAATGTTT

<400> 12488
attgaaaatt tctattccta                                                   20


<210> 12489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGATT

<400> 12489
tatcctccta ctctaataat                                                   20


<210> 12490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATAGATT

<400> 12490
catcttattt gttgcaaaga                                                   20


<210> 12491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCATGCTT

<400> 12491
tgtgcaattt ttgtcctatt                                                   20


<210> 12492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCGAGATT

<400> 12492
tcctatttca tgctttttga                                                   20


<210> 12493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCTGCTT

<400> 12493
tctgatatta aaatcatgga                                                   20


<210> 12494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGTTT

<400> 12494
aaaatcatgg atcctgcttt                                                   20


<210> 12495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGCTT

<400> 12495
atcctgcttt ctttgtttgc                                                   20


<210> 12496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATTGCTT

<400> 12496
ttattcaaca tagagttggg                                                   20


<210> 12497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GACAGATT

<400> 12497
ccatttatat ttagtgacat                                                   20


<210> 12498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGCTT

<400> 12498
tatatttagt gacatgacag                                                   20


<210> 12499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTAGCTT

<400> 12499
acatgacaga tttgcttagt                                                   20


<210> 12500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTTGTTT

<400> 12500
gacagatttg cttagtctta                                                   20


<210> 12501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGTTT

<400> 12501
atattatttc atatgacgta                                                   20


<210> 12502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTGGTTT

<400> 12502
taggttggta caaaagtaat                                                   20


<210> 12503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCCGTTT

<400> 12503
gtttttgcat tgttgaaatt                                                   20


<210> 12504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCTGTTT

<400> 12504
tttgctaatg acttattact                                                   20


<210> 12505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGCGATT

<400> 12505
gttatacaaa aagcaaattc                                                   20


<210> 12506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGGGATT

<400> 12506
catcaacaac gcatttggcc                                                   20


<210> 12507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAAGTTT

<400> 12507
tacagtgcag tggtggttca                                                   20


<210> 12508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGTTT

<400> 12508
gtgcctcata agctaaggaa                                                   20


<210> 12509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCAGATT

<400> 12509
caaaaatgaa ctatttctta                                                   20


<210> 12510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCAGCTT

<400> 12510
ttacttgaca actggcaatg                                                   20


<210> 12511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGCTT

<400> 12511
gcaccaaaaa aagtcgtggt                                                   20


<210> 12512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TACAGCTT

<400> 12512
ctgctgccgg tctgatctac                                                   20


<210> 12513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAAGTTT

<400> 12513
aagttgaatg aattgggcta                                                   20


<210> 12514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CATGGATT

<400> 12514
gagttcattg aatcccaaag                                                   20


<210> 12515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTTGATT

<400> 12515
atttctcatt ggcaaaaatg                                                   20


<210> 12516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGATT

<400> 12516
gttgattgta atggttccta                                                   20


<210> 12517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGTTT

<400> 12517
tcctactttg attaataaag                                                   20


<210> 12518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAATGATT

<400> 12518
gatgtgtttg agcctagtta                                                   20


<210> 12519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGCTT

<400> 12519
ttcattattt ggcatctctt                                                   20


<210> 12520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGAGTTT

<400> 12520
tgtacaattc ttccagtatt                                                   20


<210> 12521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATAGATT

<400> 12521
catattattt gttacaaata                                                   20


<210> 12522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGTTT

<400> 12522
tacaaatata tagattacta                                                   20


<210> 12523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGTGATT

<400> 12523
caaaatctct catttccatt                                                   20


<210> 12524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGTTT

<400> 12524
catttggtga ttcctttcct                                                   20


<210> 12525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGTGCTT

<400> 12525
ctgtatttaa taatatcttt                                                   20


<210> 12526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGCTT

<400> 12526
gctcacatgt tctttcctct                                                   20


<210> 12527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGGGCTT

<400> 12527
gtcaacactt gcagggcctc                                                   20


<210> 12528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CGTGGTTT

<400> 12528
ttatccccct ctggaggcac                                                   20


<210> 12529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGTGATT

<400> 12529
ttaacaaacc ctgatctgct                                                   20


<210> 12530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGTGTTT

<400> 12530
ccacccactt ttggtcttcc                                                   20


<210> 12531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGTGTTT

<400> 12531
gttttgacat catttgtcct                                                   20


<210> 12532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGTTT

<400> 12532
aaataactca ttttgcaaaa                                                   20


<210> 12533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCATGATT

<400> 12533
caacaatatt aaatataatt                                                   20


<210> 12534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGTGATT

<400> 12534
ttaaatataa tttcatgatt                                                   20


<210> 12535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGATT

<400> 12535
ttctctactt agtaaccatc                                                   20


<210> 12536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGGGTTT

<400> 12536
tcatttattt taaaaaatta                                                   20


<210> 12537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGTTT

<400> 12537
taaattaatt attttaaaac                                                   20


<210> 12538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTGGCTT

<400> 12538
taacaaaata ccatagactg                                                   20


<210> 12539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGATT

<400> 12539
acaaatctgg aggttgaagc                                                   20


<210> 12540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGCTT

<400> 12540
ggtctgggaa agactctctt                                                   20


<210> 12541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGGGGTTT

<400> 12541
atctccaaca tagcaacatg                                                   20


<210> 12542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTTGTTT

<400> 12542
ccaacatagc aacatggggg                                                   20


<210> 12543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCAGCTT

<400> 12543
ggggacaaaa ttcactccat                                                   20


<210> 12544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGATGCTT

<400> 12544
tttttcttgc cttactttat                                                   20


<210> 12545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATAGTTT

<400> 12545
aagtatgcat tcctaaacaa                                                   20


<210> 12546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGTTT

<400> 12546
tgcattccta aacaaaatag                                                   20


<210> 12547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGCTT

<400> 12547
tcctaaacaa aatagtttag                                                   20


<210> 12548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTTGATT

<400> 12548
aaacaaaata gtttagtttt                                                   20


<210> 12549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTTGTTT

<400> 12549
tcaaacttta tataaatgaa                                                   20


<210> 12550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGCTT

<400> 12550
tgtttatgta atcctttgca                                                   20


<210> 12551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGTTT

<400> 12551
tccttattgt tgtgcagcac                                                   20


<210> 12552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTAAGTTT

<400> 12552
gtttattaat ttttattgct                                                   20


<210> 12553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGTTT

<400> 12553
acagaaatag ttaatgtact                                                   20


<210> 12554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTGGTTT

<400> 12554
tcaaagttta tggacatttg                                                   20


<210> 12555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCGGTTT

<400> 12555
ttatggacat ttgagtggtt                                                   20


<210> 12556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGGGTTT

<400> 12556
catttgagtg gtttccggtt                                                   20


<210> 12557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTATGCTT

<400> 12557
aatagaagaa tacagcatat                                                   20


<210> 12558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTTGCTT

<400> 12558
cacctttact agataatacc                                                   20


<210> 12559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGAGTTT

<400> 12559
tacactccca ccagcagtgt                                                   20


<210> 12560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGTGATT

<400> 12560
gaacatgtaa taaaatctca                                                   20


<210> 12561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGATT

<400> 12561
tgtgatttta atttgcaact                                                   20


<210> 12562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATATGTTT

<400> 12562
aaaaggttaa gaatactttc                                                   20


<210> 12563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGATT

<400> 12563
ctttcatatg tttatggcca                                                   20


<210> 12564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGATT

<400> 12564
ggttgttctg acatttttct                                                   20


<210> 12565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTTGCTT

<400> 12565
tcattactct gaatataagc                                                   20


<210> 12566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCAGTTT

<400> 12566
attatagtat actaaaatgt                                                   20


<210> 12567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGTGCTT

<400> 12567
tcagtttttt cctgtatagt                                                   20


<210> 12568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGTTT

<400> 12568
gcttcttgtg tcatatgtaa                                                   20


<210> 12569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGTTT

<400> 12569
gaggtcataa agatattcct                                                   20


<210> 12570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGCTT

<400> 12570
ctctttgttt tttcctttca                                                   20


<210> 12571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCGGCTT

<400> 12571
agcttatcca ccacgatcaa                                                   20


<210> 12572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACGTGATT

<400> 12572
cagaaccaat gacaaaaacc                                                   20


<210> 12573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGTTT

<400> 12573
aaaagaggaa gtcaaattgt                                                   20


<210> 12574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATAGATT

<400> 12574
ccatactgcc caaagtaatt                                                   20


<210> 12575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGATT

<400> 12575
gacaaaagca agcaatgggg                                                   20


<210> 12576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATAGATT

<400> 12576
ttacacaaaa attaactcaa                                                   20


<210> 12577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGCTT

<400> 12577
ttcaggacat aggcatgggc                                                   20


<210> 12578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGCTT

<400> 12578
aatggaatcc aattaaacta                                                   20


<210> 12579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAATGCTT

<400> 12579
gagaggatgt ggagagatag                                                   20


<210> 12580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGTGATT

<400> 12580
aaccattgtg gaagacagtg                                                   20


<210> 12581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAGGATT

<400> 12581
ccattactgg gtatataccc                                                   20


<210> 12582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTATGTTT

<400> 12582
ctataaagat acaagcatgc                                                   20


<210> 12583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGGGCTT

<400> 12583
acttaaagta aaatttaaaa                                                   20


<210> 12584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGATT

<400> 12584
tgaggtgttg atccacctag                                                   20


<210> 12585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGATGTTT

<400> 12585
cttgtgtgtg gtgcaaagtt                                                   20


<210> 12586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTAGTTT

<400> 12586
gtgcaaagtt ggatgtttaa                                                   20


<210> 12587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGAGATT

<400> 12587
tgtttaatgt agtttttcca                                                   20


<210> 12588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGATGTTT

<400> 12588
gtgccacctt ttcacacatt                                                   20


<210> 12589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGTTT

<400> 12589
agatgtttac atatgtgttg                                                   20


<210> 12590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGCTT

<400> 12590
ccaatcttac accaatggca                                                   20


<210> 12591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGAGCTT

<400> 12591
caatggcaca ctgcttcaat                                                   20


<210> 12592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAAAGTTT

<400> 12592
ccactttgta tttcttcctc                                                   20


<210> 12593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGTTT

<400> 12593
aacttttgag gaagaaaatt                                                   20


<210> 12594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAAGTTT

<400> 12594
gaggaagaaa atttaaagtt                                                   20


<210> 12595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATTGATT

<400> 12595
ccaaaagaag cctgttgaaa                                                   20


<210> 12596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGATT

<400> 12596
aatctgagaa catgtctccc                                                   20


<210> 12597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGTTT

<400> 12597
agaacatgtc tccccactga                                                   20


<210> 12598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGTTT

<400> 12598
tggtattttt aaaaactatt                                                   20


<210> 12599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGATT

<400> 12599
tgttgctagt gtctatacac                                                   20


<210> 12600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TACTGTTT

<400> 12600
tatactcttt tattaattct                                                   20


<210> 12601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTTGCTT

<400> 12601
tcttcttgca cttttttttt                                                   20


<210> 12602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGTTT

<400> 12602
aactgagaag aacagacatc                                                   20


<210> 12603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAAGCTT

<400> 12603
ttttcttttg atctcaaagg                                                   20


<210> 12604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGACGCTT

<400> 12604
tccatgttca caattaagta                                                   20


<210> 12605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCGGTTT

<400> 12605
ggggtacatg tgcagaacgt                                                   20


<210> 12606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGTGGTTT

<400> 12606
cataggtgta cccgtgccat                                                   20


<210> 12607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CGGTGTTT

<400> 12607
cacttatgag tgagaacata                                                   20


<210> 12608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGTTT

<400> 12608
atgagtgaga acatacggtg                                                   20


<210> 12609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTAGTTT

<400> 12609
gtttggtttt ctgttcttgt                                                   20


<210> 12610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATGGTTT

<400> 12610
tgtgttagtt tgctgagaat                                                   20


<210> 12611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGCTT

<400> 12611
gtttgctgag aatgatggtt                                                   20


<210> 12612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGATT

<400> 12612
aatggaaatt aaactttatc                                                   20


<210> 12613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTATGATT

<400> 12613
tgttgtggca tgcattactg                                                   20


<210> 12614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAATGTTT

<400> 12614
ctcccagatg tgtggatatg                                                   20


<210> 12615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCAGATT

<400> 12615
tggaatgttt ttggaaaact                                                   20


<210> 12616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGGGTTT

<400> 12616
ctcccagatt ctgaaactat                                                   20


<210> 12617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACAGCTT

<400> 12617
atatgaagca tgataactta                                                   20


<210> 12618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGTTT

<400> 12618
ccatttgttc ttagttctgt                                                   20


<210> 12619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTATGTTT

<400> 12619
tctttgaaac tgaaaatcat                                                   20


<210> 12620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGATT

<400> 12620
attacaaaga catatagaca                                                   20


<210> 12621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAATGATT

<400> 12621
tctaggatca ccttgatgct                                                   20


<210> 12622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTAGCTT

<400> 12622
attcataaat cttagccaat                                                   20


<210> 12623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGTTT

<400> 12623
ctgcagagat gtgaactctt                                                   20


<210> 12624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTAGTTT

<400> 12624
aggtacaaac tttcatggga                                                   20


<210> 12625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCAGATT

<400> 12625
ctttcatggg aattagtttc                                                   20


<210> 12626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GATTGTTT

<400> 12626
catgggaatt agtttcatca                                                   20


<210> 12627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTAGGATT

<400> 12627
gctcaggaag aaaaccccaa                                                   20


<210> 12628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGGGATT

<400> 12628
ttgacagcag actatgggca                                                   20


<210> 12629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGCTT

<400> 12629
aggaatagct gggctcccaa                                                   20


<210> 12630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTAGTTT

<400> 12630
gcagaagtat ttaaatgtat                                                   20


<210> 12631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGTTT

<400> 12631
tctgtaaatg ccttgatgtg                                                   20


<210> 12632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAGGATT

<400> 12632
catgggggga aatgttaatc                                                   20


<210> 12633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGATT

<400> 12633
tatgaaaaca ttcatagcaa                                                   20


<210> 12634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGATT

<400> 12634
gggctggagt taccaaattt                                                   20


<210> 12635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACAGCTT

<400> 12635
tgtgaggaag agaccccctc                                                   20


<210> 12636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGGGATT

<400> 12636
ctggtcactt ggttcttttt                                                   20


<210> 12637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCTGTTT

<400> 12637
aggggatttt atttctaatt                                                   20


<210> 12638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGGAGTTT

<400> 12638
ttcaaccaga atccataaag                                                   20


<210> 12639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTATGTTT

<400> 12639
gaatccataa agaggagttt                                                   20


<210> 12640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGTGATT

<400> 12640
ataaagagga gtttgtatgt                                                   20


<210> 12641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCTGATT

<400> 12641
acacattgag agaataatta                                                   20


<210> 12642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCAGTTT

<400> 12642
tttacttaat gcctctgtgt                                                   20


<210> 12643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGAGGCTT

<400> 12643
gggatggtaa tctctacttc                                                   20


<210> 12644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAAGATT

<400> 12644
cttctgtaga atctgaaaat                                                   20


<210> 12645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGCAGCTT

<400> 12645
aatgcaactt catcaagctg                                                   20


<210> 12646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTAGTTT

<400> 12646
aaccaaagta tcttttttct                                                   20


<210> 12647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGCTT

<400> 12647
aagtatcttt tttctactag                                                   20


<210> 12648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCAGCTT

<400> 12648
gccttgcaaa atcccctgaa                                                   20


<210> 12649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCAGATT

<400> 12649
cagtcttgta tggcatgaac                                                   20


<210> 12650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTAGTTT

<400> 12650
attgacattt taaacctgct                                                   20


<210> 12651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTCTGTTT

<400> 12651
tgtgtgctct tcccatcatg                                                   20


<210> 12652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAAGGCTT

<400> 12652
gcctatctca tctgcccaaa                                                   20


<210> 12653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGATGTTT

<400> 12653
caaacctccc ctcataaaga                                                   20


<210> 12654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGATT

<400> 12654
gttgtgcatc cacaggtgtg                                                   20


<210> 12655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GACTGCTT

<400> 12655
acacttcttc tgtgtcttgg                                                   20


<210> 12656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTGGGATT

<400> 12656
ctaatgacct cattgtactt                                                   20


<210> 12657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACAAGATT

<400> 12657
aagtggacct ccaatgagaa                                                   20


<210> 12658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCATGTTT

<400> 12658
aaacaagatt ccttatacaa                                                   20


<210> 12659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCAGGCTT

<400> 12659
taaacatgag aggcattatc                                                   20


<210> 12660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTTGTTT

<400> 12660
tcttctgaca agagaaccat                                                   20


<210> 12661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAATGTTT

<400> 12661
agagaaccat ccttgttttg                                                   20


<210> 12662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTGGTTT

<400> 12662
ctctgtctct taaatcctct                                                   20


<210> 12663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAGGATT

<400> 12663
cctctcctgg tttctccctc                                                   20


<210> 12664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCTGATT

<400> 12664
ctgctagcca tatttgagat                                                   20


<210> 12665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGTTT

<400> 12665
gataattgtc atgaagaagc                                                   20


<210> 12666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TACTGATT

<400> 12666
gaagaagctc ttgtttaaac                                                   20


<210> 12667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGATT

<400> 12667
aaactactga ttctcaaact                                                   20


<210> 12668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGGGATT

<400> 12668
attctcaaac tttttgattt                                                   20


<210> 12669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 12669
tattgaggac cccaaataac                                                   20


<210> 12670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 12670
ttttgtttat gttgatacct                                                   20


<210> 12671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATATGCTT

<400> 12671
agaaattaat atatatgtat                                                   20


<210> 12672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTAGCTT

<400> 12672
aatatacagg cacacattcc                                                   20


<210> 12673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATAGTTT

<400> 12673
acatccaagt attgttatac                                                   20


<210> 12674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AACAGTTT

<400> 12674
tcattttata aacccactaa                                                   20


<210> 12675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACTGGCTT

<400> 12675
caagatcata gttgaggacc                                                   20


<210> 12676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCTGCTT

<400> 12676
ggaccactgg cttaaattca                                                   20


<210> 12677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGCTT

<400> 12677
ctgaaagctc tgcagcagtt                                                   20


<210> 12678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTGGGTTT

<400> 12678
agttatctgc ttttgaagat                                                   20


<210> 12679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTAGTTT

<400> 12679
cttttgaaga tgtgggttta                                                   20


<210> 12680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCAGGCTT

<400> 12680
tagaacttgg gcagctggtt                                                   20


<210> 12681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CGAGGCTT

<400> 12681
ctttcaagtc cagctggggc                                                   20


<210> 12682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTATGCTT

<400> 12682
cttcttggtc cttctgctcc                                                   20


<210> 12683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGCTT

<400> 12683
ttctgctccc tatgcttctc                                                   20


<210> 12684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCCTGCTT

<400> 12684
tctctctggc tttctttgtt                                                   20


<210> 12685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTTGCTT

<400> 12685
ttgttccctg cttggcagca                                                   20


<210> 12686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTTAGTTT

<400> 12686
ggagtaaagc gacggaagtt                                                   20


<210> 12687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GACAGCTT

<400> 12687
ggacataacc acagagaggt                                                   20


<210> 12688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTTGATT

<400> 12688
tgtccctctc atctgtccca                                                   20


<210> 12689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCTGTTT

<400> 12689
cctgcaaggc attcagggga                                                   20


<210> 12690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGTGCTT

<400> 12690
gggttatgtc tttgctcccc                                                   20


<210> 12691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CATTGCTT

<400> 12691
ctccccatgt gcttctatgt                                                   20


<210> 12692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCAGATT

<400> 12692
tgtaccatcc taccaccacc                                                   20


<210> 12693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTGGTTT

<400> 12693
ctcccatatt catcaaagac                                                   20


<210> 12694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCTGTTT

<400> 12694
gacattgtca acatttctcc                                                   20


<210> 12695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCAGATT

<400> 12695
cctccaagtt actggagaac                                                   20


<210> 12696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACCAGATT

<400> 12696
gctgaacact tttccccata                                                   20


<210> 12697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGCAGTTT

<400> 12697
atcatatggt atccctagtc                                                   20


<210> 12698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAGGTTT

<400> 12698
gtcagcagtt tcttctagtc                                                   20


<210> 12699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCTGCTT

<400> 12699
tctaaggacc attcctttcc                                                   20


<210> 12700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGATGCTT

<400> 12700
tctttcctat cagcatttaa                                                   20


<210> 12701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATTGGCTT

<400> 12701
cctcctctct cctgttctct                                                   20


<210> 12702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGTTT

<400> 12702
ataaaggact tacttctact                                                   20


<210> 12703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAAGCTT

<400> 12703
tccagtcact tttcagtctt                                                   20


<210> 12704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGATT

<400> 12704
tcacttttca gtctttgaag                                                   20


<210> 12705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAATGCTT

<400> 12705
tttgccctcc tatctcacta                                                   20


<210> 12706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGATT

<400> 12706
atgcttcctt gcagggatac                                                   20


<210> 12707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 12707
cccttctcag ttcttgtctt                                                   20


<210> 12708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCTAGTTT

<400> 12708
ggcacatgtc accacactcg                                                   20


<210> 12709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GGCTGTTT

<400> 12709
cttatcttga tggtcctatt                                                   20


<210> 12710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGTTT

<400> 12710
tttggctacc atgacactct                                                   20


<210> 12711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTCAGCTT

<400> 12711
tccttctcag tctctccttt                                                   20


<210> 12712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ACATGATT

<400> 12712
cctttctcag cttttcccat                                                   20


<210> 12713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGTTT

<400> 12713
gtgaataatg gcactctatc                                                   20


<210> 12714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGAGATT

<400> 12714
ttcaacagcg ctagcattta                                                   20


<210> 12715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTGGATT

<400> 12715
gattccactg tatttcagac                                                   20


<210> 12716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GTATGTTT

<400> 12716
agaacggtac ttaaactcag                                                   20


<210> 12717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GCCTGTTT

<400> 12717
actgccatta gccccaaata                                                   20


<210> 12718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGTTGCTT

<400> 12718
tacaatcaaa catctagtgc                                                   20


<210> 12719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTTTGATT

<400> 12719
cactggcctc gtatgtgtca                                                   20


<210> 12720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAAGTTT

<400> 12720
tccccagcca cactactttt                                                   20


<210> 12721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAAGGCTT

<400> 12721
tgacccattc ttttttatgt                                                   20


<210> 12722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGCTT

<400> 12722
tcctctctta ttcttgtact                                                   20


<210> 12723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAGGATT

<400> 12723
tgacctatat gaagtctatg                                                   20


<210> 12724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCTGTTT

<400> 12724
tatgaagtct atgttaggat                                                   20


<210> 12725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGATT

<400> 12725
tctgcacttt ctctataaac                                                   20


<210> 12726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGTTT

<400> 12726
ataaacatct gatttgtaat                                                   20


<210> 12727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATTGTTT

<400> 12727
gtaatttctg tttgcctttc                                                   20


<210> 12728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CATTGATT

<400> 12728
ctcacatcta ttttgttcag                                                   20


<210> 12729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AAGAGATT

<400> 12729
aataggaata taaggaacca                                                   20


<210> 12730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAGTGCTT

<400> 12730
caagcagatg gtggcagagg                                                   20


<210> 12731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCCTGCTT

<400> 12731
aaatacccct atgatggaga                                                   20


<210> 12732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CACTGCTT

<400> 12732
caatacctct gtgatataga                                                   20


<210> 12733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: GAGAGCTT

<400> 12733
gtcctccatt actttcttct                                                   20


<210> 12734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATCTGTTT

<400> 12734
ctcctgccta tttgtagttg                                                   20


<210> 12735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTCTGATT

<400> 12735
ctatgtgttg tgtgcccaaa                                                   20


<210> 12736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CAAAGATT

<400> 12736
aattcttccc ttctgagaaa                                                   20


<210> 12737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TATAGTTT

<400> 12737
tctaggggag aagagatact                                                   20


<210> 12738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTTGTTT

<400> 12738
aaatttgaat cccaggactc                                                   20


<210> 12739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGAGGATT

<400> 12739
gtgacactgg aatgcaatgt                                                   20


<210> 12740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGAGCTT

<400> 12740
agaattccag gtcctggagc                                                   20


<210> 12741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGTTT

<400> 12741
atccctccag ctaaggacaa                                                   20


<210> 12742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTTGATT

<400> 12742
atagctctgg acttgggatc                                                   20


<210> 12743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AGTAGTTT

<400> 12743
gagaaaacta ttggggtgca                                                   20


<210> 12744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: AATTGTTT

<400> 12744
tatgggcaaa ctgggctcag                                                   20


<210> 12745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TAGGGTTT

<400> 12745
tcactgaggg gtaaggatac                                                   20


<210> 12746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTGGGATT

<400> 12746
cttattggtt gacggttgtc                                                   20


<210> 12747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATAGGATT

<400> 12747
ccatatcaaa tgtatgtgtt                                                   20


<210> 12748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CTTGGATT

<400> 12748
tctgggcctg atactcactt                                                   20


<210> 12749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TCTAGTTT

<400> 12749
acaatccaag aaatatctat                                                   20


<210> 12750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: CCTGGCTT

<400> 12750
agtttagctc caagctcggc                                                   20


<210> 12751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: ATGAGTTT

<400> 12751
ctggctttca aacagtctgc                                                   20


<210> 12752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TTAAGTTT

<400> 12752
gtttttgcag gtatattccc                                                   20


<210> 12753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NNNNGHTT;
      PAM sequence: TGGGGTTT

<400> 12753
gctaatcttc atatttttga                                                   20


<210> 12754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12754
atagtccgta tgcctggcca                                                   20


<210> 12755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12755
acaaaaatag tccgtatgcc                                                   20


<210> 12756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12756
atagggcaca tttacaaaaa                                                   20


<210> 12757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12757
ggtacaaata caagtacata                                                   20


<210> 12758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12758
gggtacaaat acaagtacat                                                   20


<210> 12759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12759
agggtacaaa tacaagtaca                                                   20


<210> 12760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12760
taccaaaagg gtacaaatac                                                   20


<210> 12761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12761
aaaacctaag gttaccaaaa                                                   20


<210> 12762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12762
caaaacctaa ggttaccaaa                                                   20


<210> 12763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12763
acaaaaccta aggttaccaa                                                   20


<210> 12764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12764
agaaagccac acaaaaccta                                                   20


<210> 12765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12765
cagaaagcca cacaaaacct                                                   20


<210> 12766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12766
aaataaattc tgtttacaga                                                   20


<210> 12767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12767
attcaaataa attctgttta                                                   20


<210> 12768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12768
tgggaaaaag agtgtcagtc                                                   20


<210> 12769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12769
gactctggga aaaagagtgt                                                   20


<210> 12770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12770
taaatggact ctgggaaaaa                                                   20


<210> 12771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12771
tttaaatgga ctctgggaaa                                                   20


<210> 12772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12772
attaaattta aatggactct                                                   20


<210> 12773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12773
cattaaattt aaatggactc                                                   20


<210> 12774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12774
taaattacat taaatttaaa                                                   20


<210> 12775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12775
atagaaaaga cagagtaaag                                                   20


<210> 12776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12776
caaatagaaa agacagagta                                                   20


<210> 12777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12777
agaaacaaat agaaaagaca                                                   20


<210> 12778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12778
aaagaaacaa atagaaaaga                                                   20


<210> 12779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12779
aataaaagaa acaaatagaa                                                   20


<210> 12780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12780
tacagaataa aagaaacaaa                                                   20


<210> 12781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12781
tatagagaca tacagaataa                                                   20


<210> 12782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12782
acccgggata tagagacata                                                   20


<210> 12783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12783
ttaaaaaaac ccgggatata                                                   20


<210> 12784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12784
aattaaaaaa acccgggata                                                   20


<210> 12785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12785
aataataatt aaaaaaaccc                                                   20


<210> 12786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 12786
taataataat taaaaaaacc                                                   20


<210> 12787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12787
ctcatgtatc ctaaaactta                                                   20


<210> 12788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12788
atgggtgcag cacaccaaca                                                   20


<210> 12789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12789
aaatgacaag ttaatgggtg                                                   20


<210> 12790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12790
aatgtaaatg acaagttaat                                                   20


<210> 12791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12791
taatgtaaat gacaagttaa                                                   20


<210> 12792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12792
atatacctaa tgtaaatgac                                                   20


<210> 12793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12793
ggggggaggg atagcattag                                                   20


<210> 12794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12794
gaggggggag ggatagcatt                                                   20


<210> 12795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12795
ggagggggga gggatagcat                                                   20


<210> 12796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12796
gtggagggag gggggaggga                                                   20


<210> 12797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12797
tggggtggag ggagggggga                                                   20


<210> 12798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12798
gtggggtgga gggagggggg                                                   20


<210> 12799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12799
tgtggggtgg agggaggggg                                                   20


<210> 12800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12800
gttgtggggt ggagggaggg                                                   20


<210> 12801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12801
agttgtgggg tggagggagg                                                   20


<210> 12802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12802
cagttgtggg gtggagggag                                                   20


<210> 12803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12803
acagttgtgg ggtggaggga                                                   20


<210> 12804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12804
gacagttgtg gggtggaggg                                                   20


<210> 12805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12805
ggacagttgt ggggtggagg                                                   20


<210> 12806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12806
ggggacagtt gtggggtgga                                                   20


<210> 12807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12807
cggggacagt tgtggggtgg                                                   20


<210> 12808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12808
ccggggacag ttgtggggtg                                                   20


<210> 12809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12809
caccggggac agttgtgggg                                                   20


<210> 12810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12810
acacaccggg gacagttgtg                                                   20


<210> 12811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12811
cacacaccgg ggacagttgt                                                   20


<210> 12812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12812
tcacacaccg gggacagttg                                                   20


<210> 12813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12813
ggaacatcac acaccgggga                                                   20


<210> 12814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12814
aaggggaaca tcacacaccg                                                   20


<210> 12815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12815
gaaggggaac atcacacacc                                                   20


<210> 12816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 12816
ggaaggggaa catcacacac                                                   20


<210> 12817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12817
gaacacatgg acacaggaag                                                   20


<210> 12818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12818
agaacacatg gacacaggaa                                                   20


<210> 12819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12819
aagaacacat ggacacagga                                                   20


<210> 12820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12820
taagaacaca tggacacagg                                                   20


<210> 12821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12821
caataagaac acatggacac                                                   20


<210> 12822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12822
acaataagaa cacatggaca                                                   20


<210> 12823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12823
aattgaacaa taagaacaca                                                   20


<210> 12824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12824
ataggtggga attgaacaat                                                   20


<210> 12825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12825
gcatgttctc actcataggt                                                   20


<210> 12826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12826
cgcatgttct cactcatagg                                                   20


<210> 12827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12827
caccgcatgt tctcactcat                                                   20


<210> 12828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12828
acaccgcatg ttctcactca                                                   20


<210> 12829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12829
attctcagca aactatcgca                                                   20


<210> 12830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12830
cattctcagc aaactatcgc                                                   20


<210> 12831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12831
aagctggaaa ccatcattct                                                   20


<210> 12832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12832
tgcagggaca tggatgaagc                                                   20


<210> 12833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12833
cctttgcagg gacatggatg                                                   20


<210> 12834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12834
tcatgtcctt tgcagggaca                                                   20


<210> 12835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12835
atgagttcat gtcctttgca                                                   20


<210> 12836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12836
gatgagttca tgtcctttgc                                                   20


<210> 12837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12837
tgatgagttc atgtcctttg                                                   20


<210> 12838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12838
atgcagccat aaaaaatgat                                                   20


<210> 12839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12839
atacaccatg gaatactatg                                                   20


<210> 12840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12840
aatgtggcac atatacacca                                                   20


<210> 12841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12841
tagactggat taagaaaatg                                                   20


<210> 12842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12842
caacagtgat agactggatt                                                   20


<210> 12843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12843
aatgtccaac agtgatagac                                                   20


<210> 12844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12844
acccaaatgt ccaacagtga                                                   20


<210> 12845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12845
gaaccaaccc aaatgtccaa                                                   20


<210> 12846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12846
tattcacaat agcaaagact                                                   20


<210> 12847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12847
tggcactatt cacaatagca                                                   20


<210> 12848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12848
tattgtggca ctattcacaa                                                   20


<210> 12849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12849
atgcacacgt atgtttattg                                                   20


<210> 12850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12850
ttataaatca tactgctata                                                   20


<210> 12851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12851
attactgggt atatacccaa                                                   20


<210> 12852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12852
cattactggg tatataccca                                                   20


<210> 12853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12853
gacccagcca tcccattact                                                   20


<210> 12854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12854
tgacccagcc atcccattac                                                   20


<210> 12855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12855
accagaaata ccatttgacc                                                   20


<210> 12856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12856
attcctcagg gatctagaac                                                   20


<210> 12857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12857
gtggcaattc ctcagggatc                                                   20


<210> 12858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12858
gtcggtgtgg caattcctca                                                   20


<210> 12859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12859
agtcggtgtg gcaattcctc                                                   20


<210> 12860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12860
aagtcggtgt ggcaattcct                                                   20


<210> 12861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12861
aatcattgtg gaagtcggtg                                                   20


<210> 12862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 12862
agttcaatca ttgtggaagt                                                   20


<210> 12863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12863
aactagttca atcattgtgg                                                   20


<210> 12864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12864
gtaaactagt tcaatcattg                                                   20


<210> 12865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12865
ctgttggtgg gtctgtaaac                                                   20


<210> 12866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12866
aacactttta cactgttggt                                                   20


<210> 12867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12867
gaacactttt acactgttgg                                                   20


<210> 12868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12868
taggaacact tttacactgt                                                   20


<210> 12869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12869
tggagaggat gtggagaaat                                                   20


<210> 12870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12870
ctggagagga tgtggagaaa                                                   20


<210> 12871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12871
caggtgctgg agaggatgtg                                                   20


<210> 12872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12872
aacaggtgct ggagaggatg                                                   20


<210> 12873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12873
ggaaacaaca ggtgctggag                                                   20


<210> 12874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12874
aggaaacaac aggtgctgga                                                   20


<210> 12875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12875
tcaggaaaca acaggtgctg                                                   20


<210> 12876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12876
agtcaggaaa caacaggtgc                                                   20


<210> 12877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12877
ttaaaaagtc aggaaacaac                                                   20


<210> 12878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12878
attaaaaagt caggaaacaa                                                   20


<210> 12879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12879
atggcgatca ttaaaaagtc                                                   20


<210> 12880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12880
aatggcgatc attaaaaagt                                                   20


<210> 12881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12881
ttagaatggc gatcattaaa                                                   20


<210> 12882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12882
ccatctcaca ccagttagaa                                                   20


<210> 12883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12883
agataccatc tcacaccagt                                                   20


<210> 12884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12884
aatgagatac catctcacac                                                   20


<210> 12885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12885
atgcaaatca aaaccacaat                                                   20


<210> 12886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12886
ctcatcatca ctggccatca                                                   20


<210> 12887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12887
tgctcatcat cactggccat                                                   20


<210> 12888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12888
gaaaaaatgc tcatcatcac                                                   20


<210> 12889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12889
ctcaaaagaa gacatttatg                                                   20


<210> 12890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12890
gaacagacac ttctcaaaag                                                   20


<210> 12891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12891
tatgaacaga cacttctcaa                                                   20


<210> 12892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12892
aagtgggcga aggatatgaa                                                   20


<210> 12893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12893
tcccatcaaa aagtgggcga                                                   20


<210> 12894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12894
atcccatcaa aaagtgggcg                                                   20


<210> 12895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12895
aaaaaatccc atcaaaaagt                                                   20


<210> 12896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12896
aaaaaaatcc catcaaaaag                                                   20


<210> 12897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12897
aggaaaaaaa tcccatcaaa                                                   20


<210> 12898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12898
tgaactcaaa caaatttaca                                                   20


<210> 12899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12899
atgaactcaa acaaatttac                                                   20


<210> 12900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12900
tctgacgaag ggctaatatc                                                   20


<210> 12901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12901
caacctactc atctgacgaa                                                   20


<210> 12902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12902
gcaacctact catctgacga                                                   20


<210> 12903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12903
tgcaacctac tcatctgacg                                                   20


<210> 12904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12904
aacagaaacc tacaggatgg                                                   20


<210> 12905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12905
tgaacagaaa cctacaggat                                                   20


<210> 12906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12906
gtgaacagaa acctacagga                                                   20


<210> 12907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12907
cagagtgaac agaaacctac                                                   20


<210> 12908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12908
tcagagtgaa cagaaaccta                                                   20


<210> 12909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12909
gaaaccacca tcagagtgaa                                                   20


<210> 12910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12910
agcaaaagaa accaccatca                                                   20


<210> 12911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12911
gcagcaaaag aaaccaccat                                                   20


<210> 12912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12912
aaagagcttc tgagcagcaa                                                   20


<210> 12913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12913
taaactaaag agcttctgag                                                   20


<210> 12914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12914
cattaaacta aagagcttct                                                   20


<210> 12915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12915
tgggatctca ttaaactaaa                                                   20


<210> 12916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12916
aatgggatct cattaaacta                                                   20


<210> 12917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12917
aaaagtcaaa attgacaaat                                                   20


<210> 12918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12918
caaaagtcaa aattgacaaa                                                   20


<210> 12919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12919
accaaaagca atggcaacaa                                                   20


<210> 12920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12920
gtctaaaaca ccaaaagcaa                                                   20


<210> 12921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12921
cttcatgtct aaaacaccaa                                                   20


<210> 12922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12922
tcaggacata ggcatgggca                                                   20


<210> 12923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12923
ttcaggacat aggcatgggc                                                   20


<210> 12924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12924
accattcagg acataggcat                                                   20


<210> 12925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12925
taccattcag gacataggca                                                   20


<210> 12926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12926
ggcaatacca ttcaggacat                                                   20


<210> 12927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12927
aggcaatacc attcaggaca                                                   20


<210> 12928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12928
gaacctaggc aataccattc                                                   20


<210> 12929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12929
agaacctagg caataccatt                                                   20


<210> 12930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12930
aaaaccctag aagagaacct                                                   20


<210> 12931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12931
aaaaacccta gaagagaacc                                                   20


<210> 12932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12932
aaaccataaa aaccctagaa                                                   20


<210> 12933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12933
taaaaccata aaaaccctag                                                   20


<210> 12934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12934
acctaaaacc ataaaaaccc                                                   20


<210> 12935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12935
tggattaaag acttaaatgt                                                   20


<210> 12936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12936
aattaattca agatggatta                                                   20


<210> 12937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12937
atacaaaaat taattcaaga                                                   20


<210> 12938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12938
ccttatacaa aaattaattc                                                   20


<210> 12939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12939
catatggaga aagctgaaac                                                   20


<210> 12940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12940
actggctagc catatggaga                                                   20


<210> 12941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12941
gaaaactggc tagccatatg                                                   20


<210> 12942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12942
gggaaaactg gctagccata                                                   20


<210> 12943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12943
atggtgctgg gaaaactggc                                                   20


<210> 12944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12944
ataaatggtg ctgggaaaac                                                   20


<210> 12945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12945
cctatttaat aaatggtgct                                                   20


<210> 12946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12946
ccctatttaa taaatggtgc                                                   20


<210> 12947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12947
aggattccct atttaataaa                                                   20


<210> 12948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12948
caaaaacaag aaatggggaa                                                   20


<210> 12949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12949
acaaaaacaa gaaatgggga                                                   20


<210> 12950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12950
cctgacaaaa acaagaaatg                                                   20


<210> 12951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12951
acctgacaaa aacaagaaat                                                   20


<210> 12952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12952
aacctgacaa aaacaagaaa                                                   20


<210> 12953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12953
ttgacaaacc tgacaaaaac                                                   20


<210> 12954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12954
atggaacaga acagagccct                                                   20


<210> 12955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12955
tagaccaatg gaacagaaca                                                   20


<210> 12956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12956
tatagaccaa tggaacagaa                                                   20


<210> 12957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12957
agagatatag accaatggaa                                                   20


<210> 12958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12958
aaaacagaga tatagaccaa                                                   20


<210> 12959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12959
ctggtaccaa aacagagata                                                   20


<210> 12960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12960
atggtactgg taccaaaaca                                                   20


<210> 12961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12961
gcatggtact ggtaccaaaa                                                   20


<210> 12962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12962
taaccaaaac agcatggtac                                                   20


<210> 12963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12963
ctacagtaac caaaacagca                                                   20


<210> 12964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12964
caaggctaca gtaaccaaaa                                                   20


<210> 12965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12965
caaactatat tacaaggcta                                                   20


<210> 12966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12966
tgacttcaaa ctatattaca                                                   20


<210> 12967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12967
ctgacttcaa actatattac                                                   20


<210> 12968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12968
ttggtgtata acaaagctgg                                                   20


<210> 12969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12969
attggtgtat aacaaagctg                                                   20


<210> 12970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12970
ttattggtgt ataacaaagc                                                   20


<210> 12971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12971
tctgttattg gtgtataaca                                                   20


<210> 12972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12972
gctctctgtt tgtctgttat                                                   20


<210> 12973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12973
atgggagttc actcatgatt                                                   20


<210> 12974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12974
tttgaagcaa ttgtgaatgg                                                   20


<210> 12975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12975
tctttgaagc aattgtgaat                                                   20


<210> 12976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12976
ctctttgaag caattgtgaa                                                   20


<210> 12977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12977
taggtatttt attctctttg                                                   20


<210> 12978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12978
cccttgtaag ttgcattcct                                                   20


<210> 12979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12979
tcccttgtaa gttgcattcc                                                   20


<210> 12980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12980
aggtccttca catcccttgt                                                   20


<210> 12981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 12981
gtttgtagtt ctccttgaag                                                   20


<210> 12982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12982
ggtttgtagt tctccttgaa                                                   20


<210> 12983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12983
gtggtttgta gttctccttg                                                   20


<210> 12984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 12984
tttcactgag cagtggtttg                                                   20


<210> 12985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12985
tcttttattt cactgagcag                                                   20


<210> 12986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12986
tcctctttta tttcactgag                                                   20


<210> 12987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12987
gtatcctctt ttatttcact                                                   20


<210> 12988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12988
tcttcctacc catgagcatg                                                   20


<210> 12989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12989
attcttccta cccatgagca                                                   20


<210> 12990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 12990
tattgattct tcctacccat                                                   20


<210> 12991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 12991
tgggcagtat ggccattttc                                                   20


<210> 12992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12992
ataaattacc ttgggcagta                                                   20


<210> 12993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 12993
aatctataaa ttaccttggg                                                   20


<210> 12994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12994
ttgaatctat aaattacctt                                                   20


<210> 12995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12995
attgaatcta taaattacct                                                   20


<210> 12996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12996
cattggtagc ttgatgggga                                                   20


<210> 12997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12997
aagtcattgg tagcttgatg                                                   20


<210> 12998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 12998
aaagtcattg gtagcttgat                                                   20


<210> 12999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 12999
gaaagtcatt ggtagcttga                                                   20


<210> 13000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13000
tctgagaaga aagtcattgg                                                   20


<210> 13001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13001
aattctgaga agaaagtcat                                                   20


<210> 13002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13002
tttttccaat tctgagaaga                                                   20


<210> 13003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13003
tagttttttc caattctgag                                                   20


<210> 13004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13004
aagtagtttt ttccaattct                                                   20


<210> 13005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13005
gttccgtatg aactttaaag                                                   20


<210> 13006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13006
ttggttccgt atgaacttta                                                   20


<210> 13007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13007
tggcaatgtg ggctcttttt                                                   20


<210> 13008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13008
taggattgac ttggcaatgt                                                   20


<210> 13009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13009
ttaggattga cttggcaatg                                                   20


<210> 13010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13010
aaacaggatt aggattgact                                                   20


<210> 13011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13011
gttaaaaaaa aaacaggatt                                                   20


<210> 13012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13012
ggttaaaaaa aaaacaggat                                                   20


<210> 13013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13013
agtaaggtta aaaaaaaaac                                                   20


<210> 13014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13014
aagtaaggtt aaaaaaaaaa                                                   20


<210> 13015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13015
attagccaat caaaaaagta                                                   20


<210> 13016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13016
aattagccaa tcaaaaaagt                                                   20


<210> 13017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13017
aaacaattag ccaatcaaaa                                                   20


<210> 13018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13018
gaactatgct aagaaacaat                                                   20


<210> 13019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13019
ggacaagggg gaactatgct                                                   20


<210> 13020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13020
atttccaaag taggacaagg                                                   20


<210> 13021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13021
catttccaaa gtaggacaag                                                   20


<210> 13022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13022
tcatttccaa agtaggacaa                                                   20


<210> 13023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13023
atcatttcca aagtaggaca                                                   20


<210> 13024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13024
tatcatttcc aaagtaggac                                                   20


<210> 13025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13025
gagtatatca tttccaaagt                                                   20


<210> 13026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13026
agagtatatc atttccaaag                                                   20


<210> 13027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13027
aatagagtat atcatttcca                                                   20


<210> 13028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13028
ccagtaacaa atcagaaata                                                   20


<210> 13029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13029
tgccagtaac aaatcagaaa                                                   20


<210> 13030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13030
tagggttgcc agtaacaaat                                                   20


<210> 13031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13031
gacttaatta ttagggttgc                                                   20


<210> 13032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13032
aatgaatgac ttaattatta                                                   20


<210> 13033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13033
gaatgaatga cttaattatt                                                   20


<210> 13034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13034
agaatgaatg acttaattat                                                   20


<210> 13035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13035
atcattagac tgtgtaactt                                                   20


<210> 13036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13036
gtaaaggttt ttattatcat                                                   20


<210> 13037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13037
taaaaagtaa aaaaaagtaa                                                   20


<210> 13038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13038
ctaaaaagta aaaaaaagta                                                   20


<210> 13039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13039
taatgctaaa aagtaaaaaa                                                   20


<210> 13040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13040
gtatttctcc taatgctaaa                                                   20


<210> 13041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13041
atcaacccgt catctacatt                                                   20


<210> 13042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13042
catcaacccg tcatctacat                                                   20


<210> 13043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13043
taggtataca tgtgccatgt                                                   20


<210> 13044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13044
aatgtacatg tttgttatat                                                   20


<210> 13045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13045
caatgtacat gtttgttata                                                   20


<210> 13046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13046
aaattatact ttaaattcta                                                   20


<210> 13047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13047
aaaattatac tttaaattct                                                   20


<210> 13048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13048
taaaattata ctttaaattc                                                   20


<210> 13049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13049
aggtttacaa ataaattaaa                                                   20


<210> 13050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13050
tggagctgaa cacaggctga                                                   20


<210> 13051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13051
ctggagctga acacaggctg                                                   20


<210> 13052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13052
ttcagtctgg agctgaacac                                                   20


<210> 13053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13053
cttcagtctg gagctgaaca                                                   20


<210> 13054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13054
taagacagat cttcagtctg                                                   20


<210> 13055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13055
gataagacag atcttcagtc                                                   20


<210> 13056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13056
tgcaagataa gacagatctt                                                   20


<210> 13057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13057
gttagggatg caagataaga                                                   20


<210> 13058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13058
aagtgttagg gatgcaagat                                                   20


<210> 13059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13059
ttcctaagtg ttagggatgc                                                   20


<210> 13060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13060
agtcactttc ctaagtgtta                                                   20


<210> 13061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13061
aagtcacttt cctaagtgtt                                                   20


<210> 13062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13062
gaagtcactt tcctaagtgt                                                   20


<210> 13063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13063
aaaagtgaag tcactttcct                                                   20


<210> 13064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13064
atttgcttaa gacaaaagtg                                                   20


<210> 13065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13065
ggagcatttg cttaagacaa                                                   20


<210> 13066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13066
gtgtgctgga gcatttgctt                                                   20


<210> 13067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13067
ggcagagccc tggtgtgctg                                                   20


<210> 13068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13068
tcggcagagc cctggtgtgc                                                   20


<210> 13069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13069
agtaggtatc ggcagagccc                                                   20


<210> 13070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13070
cagaatagta ggtatcggca                                                   20


<210> 13071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13071
cacagaatag taggtatcgg                                                   20


<210> 13072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13072
taacacagaa tagtaggtat                                                   20


<210> 13073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13073
tccacttaac acagaatagt                                                   20


<210> 13074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13074
atccacttaa cacagaatag                                                   20


<210> 13075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13075
aacatccact taacacagaa                                                   20


<210> 13076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13076
ttcagaacat ccacttaaca                                                   20


<210> 13077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13077
cacagatggc aaataacatt                                                   20


<210> 13078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13078
gcataacaca tagacacaga                                                   20


<210> 13079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13079
aactgcataa cacatagaca                                                   20


<210> 13080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13080
ccattaaact gcataacaca                                                   20


<210> 13081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13081
tggaacctgc aagttctcaa                                                   20


<210> 13082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13082
tacaaatatc tggaacctgc                                                   20


<210> 13083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13083
atgctgactg tacaaatatc                                                   20


<210> 13084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13084
actgaaggga gataagagac                                                   20


<210> 13085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13085
cactgaaggg agataagaga                                                   20


<210> 13086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13086
ttagcactga agggagataa                                                   20


<210> 13087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13087
ccttagcact gaagggagat                                                   20


<210> 13088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13088
ggatacctta gcactgaagg                                                   20


<210> 13089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13089
gaggatacct tagcactgaa                                                   20


<210> 13090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13090
tgaggatacc ttagcactga                                                   20


<210> 13091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13091
gtgaggatac cttagcactg                                                   20


<210> 13092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13092
cccagaatgt gaggatacct                                                   20


<210> 13093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13093
tctctctggc ccagaatgtg                                                   20


<210> 13094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13094
atctctctgg cccagaatgt                                                   20


<210> 13095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13095
aaactagaat ctctctggcc                                                   20


<210> 13096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13096
aggtaaaact agaatctctc                                                   20


<210> 13097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13097
ccacccacaa gaggtaaaac                                                   20


<210> 13098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13098
ttctcaaccc cacccacaag                                                   20


<210> 13099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13099
cttctcaacc ccacccacaa                                                   20


<210> 13100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13100
accttctcaa ccccacccac                                                   20


<210> 13101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13101
gggagccaac ctgagaacca                                                   20


<210> 13102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13102
atgggagcca acctgagaac                                                   20


<210> 13103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13103
atttccatgg gagccaacct                                                   20


<210> 13104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13104
tagaaactag atttccatgg                                                   20


<210> 13105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13105
ggtagaaact agatttccat                                                   20


<210> 13106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13106
aggtagaaac tagatttcca                                                   20


<210> 13107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13107
tacaattaca aggtagaaac                                                   20


<210> 13108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13108
ctggtggtac aattacaagg                                                   20


<210> 13109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13109
cacctggtgg tacaattaca                                                   20


<210> 13110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13110
tcacctggtg gtacaattac                                                   20


<210> 13111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13111
cagtttccaa gttcacctgg                                                   20


<210> 13112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13112
agccagtttc caagttcacc                                                   20


<210> 13113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13113
tttcactaga gccagtttcc                                                   20


<210> 13114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13114
tttgaaaatt tcactagagc                                                   20


<210> 13115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13115
atcttttgaa aatttcacta                                                   20


<210> 13116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13116
ttatcttttg aaaatttcac                                                   20


<210> 13117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13117
ttggaaatgt atccaaatgc                                                   20


<210> 13118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13118
cttgcatgac acggagtttt                                                   20


<210> 13119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13119
tacacatctt gcatgacacg                                                   20


<210> 13120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13120
tatacacatc ttgcatgaca                                                   20


<210> 13121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13121
taatgggaaa cattggaaaa                                                   20


<210> 13122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13122
gtaatgggaa acattggaaa                                                   20


<210> 13123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13123
tgtaatggga aacattggaa                                                   20


<210> 13124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13124
taaattgtaa tgggaaacat                                                   20


<210> 13125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13125
tgcatttcct aaattgtaat                                                   20


<210> 13126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13126
atgcatttcc taaattgtaa                                                   20


<210> 13127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13127
taatttgtta cagcatccca                                                   20


<210> 13128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13128
gtaatttgtt acagcatccc                                                   20


<210> 13129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13129
ggtaatttgt tacagcatcc                                                   20


<210> 13130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13130
tagtttctgg taatttgtta                                                   20


<210> 13131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13131
attgtcatct acctagtttc                                                   20


<210> 13132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13132
ttctattatt gtcatctacc                                                   20


<210> 13133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13133
atctagcctc agaagtgtaa                                                   20


<210> 13134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13134
acatctagcc tcagaagtgt                                                   20


<210> 13135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13135
ttttagacat ctagcctcag                                                   20


<210> 13136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13136
tgattttaga catctagcct                                                   20


<210> 13137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13137
ataccttgat tttagacatc                                                   20


<210> 13138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13138
ctctgccaat accttgattt                                                   20


<210> 13139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13139
tgcgggcttc agagggaaca                                                   20


<210> 13140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13140
tctcacctgc gggcttcaga                                                   20


<210> 13141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13141
ttctcacctg cgggcttcag                                                   20


<210> 13142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13142
gttctcacct gcgggcttca                                                   20


<210> 13143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13143
cggttctcac ctgcgggctt                                                   20


<210> 13144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13144
aggcaacggt tctcacctgc                                                   20


<210> 13145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13145
aaggcaacgg ttctcacctg                                                   20


<210> 13146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13146
ggaggagaca tggaaggcaa                                                   20


<210> 13147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13147
aagctaggag gagacatgga                                                   20


<210> 13148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13148
gaagctagga ggagacatgg                                                   20


<210> 13149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13149
gctgaagcta ggaggagaca                                                   20


<210> 13150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13150
aagattgctg aagctaggag                                                   20


<210> 13151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13151
caaagattgc tgaagctagg                                                   20


<210> 13152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13152
gcaaagattg ctgaagctag                                                   20


<210> 13153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13153
tggcaaagat tgctgaagct                                                   20


<210> 13154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13154
atggcaaaga ttgctgaagc                                                   20


<210> 13155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13155
aggaatggca aagattgctg                                                   20


<210> 13156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13156
gtgcaggcca aggaatggca                                                   20


<210> 13157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13157
tacatgtgca ggccaaggaa                                                   20


<210> 13158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13158
agagatacat gtgcaggcca                                                   20


<210> 13159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13159
gagagataca tgtgcaggcc                                                   20


<210> 13160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13160
aatcggagag atacatgtgc                                                   20


<210> 13161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13161
aaatcggaga gatacatgtg                                                   20


<210> 13162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13162
agacacagga agaaatcgga                                                   20


<210> 13163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13163
ggagacacag gaagaaatcg                                                   20


<210> 13164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13164
atggagacac aggaagaaat                                                   20


<210> 13165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13165
cagctgtatg gagacacagg                                                   20


<210> 13166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13166
agacagctgt atggagacac                                                   20


<210> 13167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13167
aagacagctg tatggagaca                                                   20


<210> 13168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13168
aaagaaaaga cagctgtatg                                                   20


<210> 13169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13169
acaaagaaaa gacagctgta                                                   20


<210> 13170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13170
aaacacacac aaagaaaaga                                                   20


<210> 13171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13171
aaaaaaacac acacaaagaa                                                   20


<210> 13172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13172
tgcagaaaaa aacacacaca                                                   20


<210> 13173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13173
gagaatacca tgggaagatg                                                   20


<210> 13174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13174
agagaggaga ataccatggg                                                   20


<210> 13175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13175
cacagagagg agaataccat                                                   20


<210> 13176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13176
acacagagag gagaatacca                                                   20


<210> 13177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13177
gaacagagac acacagagag                                                   20


<210> 13178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13178
ttgaacagag acacacagag                                                   20


<210> 13179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13179
tttgaacaga gacacacaga                                                   20


<210> 13180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13180
aatttgaaca gagacacaca                                                   20


<210> 13181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13181
ggaatttgaa cagagacaca                                                   20


<210> 13182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13182
atatgagggg aatttgaaca                                                   20


<210> 13183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13183
aaatatgagg ggaatttgaa                                                   20


<210> 13184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13184
tggtgttgct aaaatatgag                                                   20


<210> 13185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13185
ctggtgttgc taaaatatga                                                   20


<210> 13186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13186
actggtgttg ctaaaatatg                                                   20


<210> 13187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13187
gactggtgtt gctaaaatat                                                   20


<210> 13188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13188
gtgagcccta atccaatgac                                                   20


<210> 13189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13189
aaacaaattc agatgaaggt                                                   20


<210> 13190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13190
atgtaaacaa attcagatga                                                   20


<210> 13191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13191
gatgtaaaca aattcagatg                                                   20


<210> 13192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13192
tttgcagatg taaacaaatt                                                   20


<210> 13193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13193
atttgacatt aaggtttttg                                                   20


<210> 13194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13194
tgtgacctta tttgacatta                                                   20


<210> 13195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13195
ttgtgacctt atttgacatt                                                   20


<210> 13196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13196
tatgttgaag ttctaaccaa                                                   20


<210> 13197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13197
ttccctaaaa gggtatgttg                                                   20


<210> 13198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13198
ttgaataatg ttccctaaaa                                                   20


<210> 13199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13199
gttgaataat gttccctaaa                                                   20


<210> 13200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13200
ggttgaataa tgttccctaa                                                   20


<210> 13201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13201
tttatgttga attatgcttt                                                   20


<210> 13202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13202
ctttatgttg aattatgctt                                                   20


<210> 13203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13203
gaattatgct ccctaaacat                                                   20


<210> 13204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13204
tgaattatgc tccctaaaca                                                   20


<210> 13205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13205
ctcaaaagta tttttacttt                                                   20


<210> 13206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13206
gcagatgata ctattctcaa                                                   20


<210> 13207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13207
tcagactggt tctattaaag                                                   20


<210> 13208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13208
ccatcagact ggttctatta                                                   20


<210> 13209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13209
agtgtgccaa accatcagac                                                   20


<210> 13210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13210
aattaagtgt gccaaaccat                                                   20


<210> 13211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13211
caatgatatg tgaaagaatt                                                   20


<210> 13212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13212
atttttacaa tgatatgtga                                                   20


<210> 13213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13213
tggacagaga gtttgggcac                                                   20


<210> 13214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13214
gtggacagag agtttgggca                                                   20


<210> 13215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13215
gctaagtgga cagagagttt                                                   20


<210> 13216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13216
agctaagtgg acagagagtt                                                   20


<210> 13217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13217
aagacagcta agtggacaga                                                   20


<210> 13218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13218
ataagacagc taagtggaca                                                   20


<210> 13219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13219
ttataagaca gctaagtgga                                                   20


<210> 13220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13220
gtgtttataa gacagctaag                                                   20


<210> 13221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13221
caagtgttta taagacagct                                                   20


<210> 13222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13222
tagcccaagt gtttataaga                                                   20


<210> 13223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13223
atactagccc aagtgtttat                                                   20


<210> 13224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13224
gccatctgag atactagccc                                                   20


<210> 13225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13225
gaaaaagcca tctgagatac                                                   20


<210> 13226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13226
ggatgatgaa aaagccatct                                                   20


<210> 13227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13227
atcccatgtg gatgatgaaa                                                   20


<210> 13228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13228
ttcaacgtct aaatcccatg                                                   20


<210> 13229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13229
gagcacagat actgactgtg                                                   20


<210> 13230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13230
taccactgaa cccgggagca                                                   20


<210> 13231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13231
tctcgtacca ctgaacccgg                                                   20


<210> 13232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13232
tctctcgtac cactgaaccc                                                   20


<210> 13233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13233
ctctctcgta ccactgaacc                                                   20


<210> 13234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13234
cctgatttat tctaaaagat                                                   20


<210> 13235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13235
gaatgcctga tttattctaa                                                   20


<210> 13236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13236
ggtaccaagc catctcaaat                                                   20


<210> 13237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13237
gatgggatag cagaggtacc                                                   20


<210> 13238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13238
agatgatgat gggatagcag                                                   20


<210> 13239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13239
aagatgatga tgggatagca                                                   20


<210> 13240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13240
ataagatgat gatgggatag                                                   20


<210> 13241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13241
ttaataagat gatgatggga                                                   20


<210> 13242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13242
caggttaata agatgatgat                                                   20


<210> 13243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13243
gcaggttaat aagatgatga                                                   20


<210> 13244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13244
atccacagat gcaggttaat                                                   20


<210> 13245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13245
ttggcagcat ccacagatgc                                                   20


<210> 13246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13246
gttggcagca tccacagatg                                                   20


<210> 13247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13247
ctgggagttg gcagcatcca                                                   20


<210> 13248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13248
agatgcttac tgggagttgg                                                   20


<210> 13249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13249
tcaagatgct tactgggagt                                                   20


<210> 13250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13250
gctctcaaga tgcttactgg                                                   20


<210> 13251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13251
aggctctcaa gatgcttact                                                   20


<210> 13252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13252
gaggctctca agatgcttac                                                   20


<210> 13253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13253
aagaagtcaa agaggctctc                                                   20


<210> 13254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13254
tagcccataa gaagtcaaag                                                   20


<210> 13255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13255
ttagcccata agaagtcaaa                                                   20


<210> 13256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13256
tattagccca taagaagtca                                                   20


<210> 13257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13257
tgtcactatt agcccataag                                                   20


<210> 13258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13258
ttctgtcact attagcccat                                                   20


<210> 13259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13259
tctccctttt ctgtcactat                                                   20


<210> 13260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13260
tcaagaatac agatttgccg                                                   20


<210> 13261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13261
ctcaagaata cagatttgcc                                                   20


<210> 13262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13262
tctcacatgc ctcaagaata                                                   20


<210> 13263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13263
tgatacatct cacatgcctc                                                   20


<210> 13264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13264
tgtataatta caaagcacag                                                   20


<210> 13265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13265
atttgtataa ttacaaagca                                                   20


<210> 13266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13266
tttccatttg tataattaca                                                   20


<210> 13267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13267
tatatatttg atcatttcat                                                   20


<210> 13268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13268
atcacaaaga ttcaaatata                                                   20


<210> 13269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13269
cattcccagc cacaatcaca                                                   20


<210> 13270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13270
attaactctt ggcccattcc                                                   20


<210> 13271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13271
catgatcttc cattaactct                                                   20


<210> 13272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13272
ggacataggg attgtaatga                                                   20


<210> 13273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13273
ctataacaac ataggacata                                                   20


<210> 13274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13274
cctataacaa cataggacat                                                   20


<210> 13275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13275
ccctataaca acataggaca                                                   20


<210> 13276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13276
aagactccct ataacaacat                                                   20


<210> 13277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13277
aaagactccc tataacaaca                                                   20


<210> 13278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13278
ttttgagatg aagaaaagca                                                   20


<210> 13279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13279
gcagattttg agatgaagaa                                                   20


<210> 13280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13280
atgttgcaga ttttgagatg                                                   20


<210> 13281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13281
aaaggcatgt tgcagatttt                                                   20


<210> 13282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13282
tttaggccaa aggcatgttg                                                   20


<210> 13283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13283
gaggagttta tttaggccaa                                                   20


<210> 13284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13284
agaggagttt atttaggcca                                                   20


<210> 13285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13285
attgtcagag gagtttattt                                                   20


<210> 13286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13286
aattgtcaga ggagtttatt                                                   20


<210> 13287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13287
tggagtaaga attgtcagag                                                   20


<210> 13288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13288
aatggagtaa gaattgtcag                                                   20


<210> 13289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13289
gaatggagta agaattgtca                                                   20


<210> 13290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13290
ctgaatggag taagaattgt                                                   20


<210> 13291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13291
ttgtatgaac tgaatggagt                                                   20


<210> 13292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13292
ttaattgtat gaactgaatg                                                   20


<210> 13293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13293
gattaattgt atgaactgaa                                                   20


<210> 13294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13294
aataggaatt aagcccccaa                                                   20


<210> 13295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13295
caagagataa aataggaatt                                                   20


<210> 13296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13296
ccaagaacaa gagataaaat                                                   20


<210> 13297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13297
tccaagaaca agagataaaa                                                   20


<210> 13298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13298
gggcactgct ccaagaacaa                                                   20


<210> 13299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13299
atgggcactg ctccaagaac                                                   20


<210> 13300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13300
tatatgatgg gcactgctcc                                                   20


<210> 13301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13301
ttaattacgt actatatgat                                                   20


<210> 13302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13302
attaattacg tactatatga                                                   20


<210> 13303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13303
tagataaaag gtatggccag                                                   20


<210> 13304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13304
cagtagataa aaggtatggc                                                   20


<210> 13305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13305
gatccagtag ataaaaggta                                                   20


<210> 13306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13306
atgatgatcc agtagataaa                                                   20


<210> 13307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13307
aatgatgatc cagtagataa                                                   20


<210> 13308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13308
tcatgagaat gatgatccag                                                   20


<210> 13309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13309
taatcatgag aatgatgatc                                                   20


<210> 13310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13310
agaagaaaaa gtataatcat                                                   20


<210> 13311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13311
gttaatataa tcagaagaaa                                                   20


<210> 13312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13312
tccatagtta atataatcag                                                   20


<210> 13313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13313
aactccatag ttaatataat                                                   20


<210> 13314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13314
acctggcgtc cagaactcca                                                   20


<210> 13315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13315
tttttacatt acctggcgtc                                                   20


<210> 13316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13316
aggagagttt ttacattacc                                                   20


<210> 13317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13317
taatcagaca ttaaggagga                                                   20


<210> 13318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13318
cataatcaga cattaaggag                                                   20


<210> 13319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13319
ctcataatca gacattaagg                                                   20


<210> 13320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13320
tctcataatc agacattaag                                                   20


<210> 13321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13321
catctcataa tcagacatta                                                   20


<210> 13322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13322
acatctcata atcagacatt                                                   20


<210> 13323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13323
gtctgttcac atctcataat                                                   20


<210> 13324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13324
cagcttttga atacattcca                                                   20


<210> 13325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13325
ggcagctttt gaatacattc                                                   20


<210> 13326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13326
ctgttgtgta gctaaagagg                                                   20


<210> 13327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13327
tttctgttgt gtagctaaag                                                   20


<210> 13328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13328
ctttctgttg tgtagctaaa                                                   20


<210> 13329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13329
acctttctgt tgtgtagcta                                                   20


<210> 13330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13330
ggctggacct ttctgttgtg                                                   20


<210> 13331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13331
ttttctgagg ctgaaatggc                                                   20


<210> 13332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13332
actcttttct gaggctgaaa                                                   20


<210> 13333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13333
gggaaaagca ctcttttctg                                                   20


<210> 13334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13334
tgggaaaagc actcttttct                                                   20


<210> 13335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13335
ctgccccatt tatatgggaa                                                   20


<210> 13336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13336
ggtgcctgcc ccatttatat                                                   20


<210> 13337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13337
tggtgcctgc cccatttata                                                   20


<210> 13338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13338
tctcgtgctg tagaactcca                                                   20


<210> 13339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13339
agacttcgca tctcgtgctg                                                   20


<210> 13340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13340
aagaaaatga atgctttcta                                                   20


<210> 13341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13341
tgtaaaattg gtgggaaggg                                                   20


<210> 13342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13342
acttgtaaaa ttggtgggaa                                                   20


<210> 13343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13343
cacttgtaaa attggtggga                                                   20


<210> 13344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13344
tcacttgtaa aattggtggg                                                   20


<210> 13345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13345
tcctcacttg taaaattggt                                                   20


<210> 13346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13346
ttcctcactt gtaaaattgg                                                   20


<210> 13347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13347
aatttcctca cttgtaaaat                                                   20


<210> 13348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13348
tgtctggctg accagggcta                                                   20


<210> 13349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13349
accaattgtc tggctgacca                                                   20


<210> 13350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13350
caccaattgt ctggctgacc                                                   20


<210> 13351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13351
ccaccaattg tctggctgac                                                   20


<210> 13352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13352
taacttttcc accaattgtc                                                   20


<210> 13353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13353
tgggatctgg aaatgccagt                                                   20


<210> 13354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13354
gtcctgggat ctggaaatgc                                                   20


<210> 13355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13355
aagagcactg tcctgggatc                                                   20


<210> 13356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13356
gcaggaaaga gcactgtcct                                                   20


<210> 13357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13357
agcaggaaag agcactgtcc                                                   20


<210> 13358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13358
aggctgggtg gagcaggaaa                                                   20


<210> 13359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13359
tgaggctggg tggagcagga                                                   20


<210> 13360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13360
agattgaggc tgggtggagc                                                   20


<210> 13361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13361
gagattgagg ctgggtggag                                                   20


<210> 13362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13362
tttgagattg aggctgggtg                                                   20


<210> 13363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13363
agtttgagat tgaggctggg                                                   20


<210> 13364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13364
ttcagtttga gattgaggct                                                   20


<210> 13365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13365
tttcagtttg agattgaggc                                                   20


<210> 13366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13366
tatttttcag tttgagattg                                                   20


<210> 13367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13367
atatttttca gtttgagatt                                                   20


<210> 13368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13368
atcctgatat ttttcagttt                                                   20


<210> 13369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13369
tctgggatcc tgatattttt                                                   20


<210> 13370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13370
tcacttaccc ctcactttct                                                   20


<210> 13371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13371
gtcacttacc cctcactttc                                                   20


<210> 13372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13372
gtgatgctga cctgtatcat                                                   20


<210> 13373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13373
cacaccagcg ttatatcata                                                   20


<210> 13374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13374
ttttaaatgt atgtccacac                                                   20


<210> 13375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13375
ctatgtcatg aaaagccttt                                                   20


<210> 13376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13376
cctgtggcct atgtcatgaa                                                   20


<210> 13377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13377
ctgacccagg gtaacacctg                                                   20


<210> 13378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13378
cggacaactg ctctgaccca                                                   20


<210> 13379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13379
tcggacaact gctctgaccc                                                   20


<210> 13380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13380
gtcggacaac tgctctgacc                                                   20


<210> 13381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13381
tgactgcatg tgagagctgt                                                   20


<210> 13382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13382
ttttgcatga ctgcatgtga                                                   20


<210> 13383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13383
gattttgcat gactgcatgt                                                   20


<210> 13384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13384
agagattggc aatattattt                                                   20


<210> 13385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13385
cagagattgg caatattatt                                                   20


<210> 13386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13386
gtggagcacc atacagagat                                                   20


<210> 13387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13387
cctctgtgga gcaccataca                                                   20


<210> 13388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13388
gtcctctgtg gagcaccata                                                   20


<210> 13389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13389
gtccaaggta gtcctctgtg                                                   20


<210> 13390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13390
aggtccaagg tagtcctctg                                                   20


<210> 13391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13391
acattactga aggtccaagg                                                   20


<210> 13392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13392
agaacattac tgaaggtcca                                                   20


<210> 13393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13393
aagaacatta ctgaaggtcc                                                   20


<210> 13394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13394
tagaacaaga acattactga                                                   20


<210> 13395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13395
atagaacaag aacattactg                                                   20


<210> 13396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13396
aacttccaaa gatatagaac                                                   20


<210> 13397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13397
gaccagaact tccaaagata                                                   20


<210> 13398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13398
tctcaggacc agaacttcca                                                   20


<210> 13399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13399
tgagacaaac ttctcaggac                                                   20


<210> 13400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13400
tttactgaga caaacttctc                                                   20


<210> 13401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13401
atttactgag acaaacttct                                                   20


<210> 13402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13402
gtaatcagat tatatttact                                                   20


<210> 13403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13403
ccttttattt ttgttgtaat                                                   20


<210> 13404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13404
tcatgggttc tcttactctc                                                   20


<210> 13405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13405
gaatttcaat atcagatcat                                                   20


<210> 13406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13406
tgaatttcaa tatcagatca                                                   20


<210> 13407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13407
tcccttctga atttcaatat                                                   20


<210> 13408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13408
aaataggagt cagaagctaa                                                   20


<210> 13409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13409
acaaatagga gtcagaagct                                                   20


<210> 13410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13410
catacacaaa taggagtcag                                                   20


<210> 13411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13411
catcatacac aaataggagt                                                   20


<210> 13412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13412
aaaccatcat acacaaatag                                                   20


<210> 13413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13413
aaaaaccatc atacacaaat                                                   20


<210> 13414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13414
aaaaaaccat catacacaaa                                                   20


<210> 13415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13415
aactgggcag ggaatgcaac                                                   20


<210> 13416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13416
cacaatgtca gaactgggca                                                   20


<210> 13417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13417
tcacaatgtc agaactgggc                                                   20


<210> 13418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13418
gtcacaatgt cagaactggg                                                   20


<210> 13419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13419
ctggtcacaa tgtcagaact                                                   20


<210> 13420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13420
actggtcaca atgtcagaac                                                   20


<210> 13421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13421
catgccactg gtcacaatgt                                                   20


<210> 13422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13422
gcctcaccaa tgcatgccac                                                   20


<210> 13423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13423
ttgcagatca cacccagcta                                                   20


<210> 13424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13424
ttcccattgc agatcacacc                                                   20


<210> 13425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13425
gtgttaactc tttcccattg                                                   20


<210> 13426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13426
cactccagcc tggatatgtt                                                   20


<210> 13427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13427
ctagtgagaa cactccagcc                                                   20


<210> 13428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13428
gggccctagt gagaacactc                                                   20


<210> 13429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13429
gattgcccct gggccctagt                                                   20


<210> 13430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13430
agctgattgc ccctgggccc                                                   20


<210> 13431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13431
gtatggagct gattgcccct                                                   20


<210> 13432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13432
agtatggagc tgattgcccc                                                   20


<210> 13433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13433
aagatgaagc caccagtatg                                                   20


<210> 13434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13434
tgaagatgaa gccaccagta                                                   20


<210> 13435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13435
caaaatgaag atgaagccac                                                   20


<210> 13436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13436
ctcaatacaa aatgaagatg                                                   20


<210> 13437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13437
atctagctca atacaaaatg                                                   20


<210> 13438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13438
agagtcaaca tgaggacatc                                                   20


<210> 13439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13439
ttagtgatag agtcaacatg                                                   20


<210> 13440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13440
cttagtgata gagtcaacat                                                   20


<210> 13441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13441
cactagaggc cttagtgata                                                   20


<210> 13442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13442
gtcactagag gccttagtga                                                   20


<210> 13443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13443
gagagtgtca ctagaggcct                                                   20


<210> 13444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13444
tcctatgaga gtgtcactag                                                   20


<210> 13445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13445
gtcctatgag agtgtcacta                                                   20


<210> 13446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13446
ccgtcctatg agagtgtcac                                                   20


<210> 13447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13447
tcattcccac cgtcctatga                                                   20


<210> 13448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13448
catcattccc accgtcctat                                                   20


<210> 13449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13449
aaatgaaaat tgtgtactcc                                                   20


<210> 13450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13450
tgaaggtttt gttgcattca                                                   20


<210> 13451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13451
gctgcatcac tcccagatga                                                   20


<210> 13452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13452
ggctgcatca ctcccagatg                                                   20


<210> 13453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13453
ggaggaggct gcatcactcc                                                   20


<210> 13454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13454
tgtgcccaga gctgaggagg                                                   20


<210> 13455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13455
gtgtgcccag agctgaggag                                                   20


<210> 13456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13456
atgtgtgccc agagctgagg                                                   20


<210> 13457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13457
catgtgtgcc cagagctgag                                                   20


<210> 13458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13458
cccatgtgtg cccagagctg                                                   20


<210> 13459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13459
ccccatgtgt gcccagagct                                                   20


<210> 13460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13460
taacacccca tgtgtgccca                                                   20


<210> 13461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13461
tctaacaccc catgtgtgcc                                                   20


<210> 13462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13462
ctatgtgctg caccgctcca                                                   20


<210> 13463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13463
gtcattcaaa aggcctatcg                                                   20


<210> 13464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13464
ctgtcattca aaaggcctat                                                   20


<210> 13465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13465
ttcagccact gtcattcaaa                                                   20


<210> 13466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13466
tttcagccac tgtcattcaa                                                   20


<210> 13467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13467
atggaagcaa gaagacattt                                                   20


<210> 13468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13468
cactctccga tggaagcaag                                                   20


<210> 13469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13469
aaccactctc cgatggaagc                                                   20


<210> 13470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13470
tagcaaccac tctccgatgg                                                   20


<210> 13471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13471
caatagcaac cactctccga                                                   20


<210> 13472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13472
aaaatcatcc tatgaaccaa                                                   20


<210> 13473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13473
aaatatggag gagaagttta                                                   20


<210> 13474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13474
tgaaggcaaa tatggaggag                                                   20


<210> 13475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13475
ctctgaaggc aaatatggag                                                   20


<210> 13476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13476
ttctctgaag gcaaatatgg                                                   20


<210> 13477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13477
attctctgaa ggcaaatatg                                                   20


<210> 13478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13478
ggattctctg aaggcaaata                                                   20


<210> 13479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13479
cggggagttg gattctctga                                                   20


<210> 13480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13480
ccggggagtt ggattctctg                                                   20


<210> 13481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13481
cctaggagaa tccggggagt                                                   20


<210> 13482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13482
atgtcctagg agaatccggg                                                   20


<210> 13483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13483
gaatgtccta ggagaatccg                                                   20


<210> 13484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13484
agaatgtcct aggagaatcc                                                   20


<210> 13485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13485
aagaatgtcc taggagaatc                                                   20


<210> 13486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13486
tttcaccaag aatgtcctag                                                   20


<210> 13487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13487
gctttcacca agaatgtcct                                                   20


<210> 13488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13488
tgctttcacc aagaatgtcc                                                   20


<210> 13489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13489
acatcctttt tgctttcacc                                                   20


<210> 13490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13490
tggagataag atccactgct                                                   20


<210> 13491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13491
tgcctttggt ccctggagat                                                   20


<210> 13492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13492
ggacctgcct ttggtccctg                                                   20


<210> 13493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13493
atggacctgc ctttggtccc                                                   20


<210> 13494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13494
gatccagatg gacctgcctt                                                   20


<210> 13495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13495
tcgaaatata ctgatccaga                                                   20


<210> 13496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13496
ccaatcgaaa tatactgatc                                                   20


<210> 13497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13497
gacactctct ctggtcccct                                                   20


<210> 13498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13498
gactttgcag acactctctc                                                   20


<210> 13499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13499
ttctgctctc tcggactttg                                                   20


<210> 13500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13500
tattaccttt tctgctctct                                                   20


<210> 13501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13501
agtttgaccc agaggccact                                                   20


<210> 13502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13502
ctgggagaag tttgacccag                                                   20


<210> 13503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13503
cctgggagaa gtttgaccca                                                   20


<210> 13504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13504
gacctgggag aagtttgacc                                                   20


<210> 13505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13505
tgttctatga gacctgggag                                                   20


<210> 13506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13506
acatgttcta tgagacctgg                                                   20


<210> 13507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13507
tgacatgttc tatgagacct                                                   20


<210> 13508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13508
ttgacatgtt ctatgagacc                                                   20


<210> 13509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13509
acgactttga catgttctat                                                   20


<210> 13510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13510
gagcactgag cccctgagtg                                                   20


<210> 13511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13511
agagcactga gcccctgagt                                                   20


<210> 13512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13512
gaggagagca ctgagcccct                                                   20


<210> 13513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13513
tggccacgga ggagagcact                                                   20


<210> 13514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13514
ttcaatgtgg ccacggagga                                                   20


<210> 13515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13515
acttcaatgt ggccacggag                                                   20


<210> 13516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13516
gaacttcaat gtggccacgg                                                   20


<210> 13517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13517
agaacttcaa tgtggccacg                                                   20


<210> 13518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13518
ggagaacttc aatgtggcca                                                   20


<210> 13519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13519
gattctggag aacttcaatg                                                   20


<210> 13520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13520
tgtacattgc agtgattctg                                                   20


<210> 13521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13521
catgtacatt gcagtgattc                                                   20


<210> 13522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13522
catggtcaac atgtacattg                                                   20


<210> 13523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13523
catcatctcc ttcctcatca                                                   20


<210> 13524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13524
gactgtggga gcccagccgt                                                   20


<210> 13525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13525
ggactgtggg agcccagccg                                                   20


<210> 13526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13526
cagaggggac tgtgggagcc                                                   20


<210> 13527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13527
ggcaccagag gggactgtgg                                                   20


<210> 13528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13528
atggcaccag aggggactgt                                                   20


<210> 13529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13529
aatggcacca gaggggactg                                                   20


<210> 13530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13530
caacagcaat ggcaccagag                                                   20


<210> 13531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13531
ccaacagcaa tggcaccaga                                                   20


<210> 13532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13532
cccaacagca atggcaccag                                                   20


<210> 13533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13533
gcccaacagc aatggcacca                                                   20


<210> 13534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13534
ctgcccaaca gcaatggcac                                                   20


<210> 13535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13535
cccaatctgc ccaacagcaa                                                   20


<210> 13536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13536
tgtgacccca atctgcccaa                                                   20


<210> 13537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13537
tcagccccat cctcaacaca                                                   20


<210> 13538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13538
ctcagcccca tcctcaacac                                                   20


<210> 13539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13539
cctcagcccc atcctcaaca                                                   20


<210> 13540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13540
gccggctggg atggcctcct                                                   20


<210> 13541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13541
accacgtcgg ccggctggga                                                   20


<210> 13542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13542
gattaccacg tcggccggct                                                   20


<210> 13543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13543
agattaccac gtcggccggc                                                   20


<210> 13544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13544
ttccagatta ccacgtcggc                                                   20


<210> 13545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13545
cctcttccag attaccacgt                                                   20


<210> 13546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13546
acagcatgct gtgcctcttc                                                   20


<210> 13547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13547
aacttccaga ccttcgccaa                                                   20


<210> 13548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13548
tcgacgacat gttcaacttc                                                   20


<210> 13549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13549
ccccatgtga ggtgggaggc                                                   20


<210> 13550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13550
ctttccccat gtgaggtggg                                                   20


<210> 13551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13551
gctttcccca tgtgaggtgg                                                   20


<210> 13552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13552
cagctttccc catgtgaggt                                                   20


<210> 13553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13553
ccagctttcc ccatgtgagg                                                   20


<210> 13554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13554
tgtccagctt tccccatgtg                                                   20


<210> 13555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13555
atgtccagct ttccccatgt                                                   20


<210> 13556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13556
tactctatct tcggtatgtc                                                   20


<210> 13557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13557
atgttcatct actctatctt                                                   20


<210> 13558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13558
tgcctgccct cttcaacatc                                                   20


<210> 13559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13559
ctgcctgccc tcttcaacat                                                   20


<210> 13560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13560
gactgatccg agcggccaag                                                   20


<210> 13561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13561
agactgatcc gagcggccaa                                                   20


<210> 13562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13562
cagactgatc cgagcggcca                                                   20


<210> 13563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13563
tcagactgat ccgagcggcc                                                   20


<210> 13564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13564
catcctcaga ctgatccgag                                                   20


<210> 13565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13565
ccgcatcctc agactgatcc                                                   20


<210> 13566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13566
gcccgaattg gccgcatcct                                                   20


<210> 13567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13567
gtcatccgcc tggcccgaat                                                   20


<210> 13568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13568
gctcttcaga gtcatccgcc                                                   20


<210> 13569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13569
cttctcccca acgctcttca                                                   20


<210> 13570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13570
tacttctccc caacgctctt                                                   20


<210> 13571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13571
gcaattctta agtcacttca                                                   20


<210> 13572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13572
tgattttttc tgcaattctt                                                   20


<210> 13573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13573
taatttcttc cttcttttaa                                                   20


<210> 13574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13574
ataatttctt ccttctttta                                                   20


<210> 13575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13575
tcatggctgg agatactaat                                                   20


<210> 13576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13576
tttgtcacgt ctcatggctg                                                   20


<210> 13577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13577
actttgtcac gtctcatggc                                                   20


<210> 13578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13578
gccaactttg tcacgtctca                                                   20


<210> 13579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13579
agcaaagcag agtgtcatca                                                   20


<210> 13580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13580
agtctatacc aagcaaagca                                                   20


<210> 13581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13581
gcagtctata ccaagcaaag                                                   20


<210> 13582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13582
gtggcagtct ataccaagca                                                   20


<210> 13583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13583
cccaagtggc agtctatacc                                                   20


<210> 13584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13584
aaatgtggat gcccaagtgg                                                   20


<210> 13585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13585
ctcaaatgtg gatgcccaag                                                   20


<210> 13586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13586
gtcctcaaat gtggatgccc                                                   20


<210> 13587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13587
gggcccagag tcctcaaatg                                                   20


<210> 13588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13588
tgccaggctc tgagggccca                                                   20


<210> 13589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13589
catgccaggc tctgagggcc                                                   20


<210> 13590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13590
cctaccatgc caggctctga                                                   20


<210> 13591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13591
acctaccatg ccaggctctg                                                   20


<210> 13592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13592
tacctaccat gccaggctct                                                   20


<210> 13593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13593
tttgtgctac ctaccatgcc                                                   20


<210> 13594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13594
ctttgtgcta cctaccatgc                                                   20


<210> 13595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13595
ttatgcaatg ggcatttact                                                   20


<210> 13596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13596
gaagagagga cttatgcaat                                                   20


<210> 13597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13597
ggaagagagg acttatgcaa                                                   20


<210> 13598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13598
gtaagacgga ggaggaagag                                                   20


<210> 13599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13599
ggtaagacgg aggaggaaga                                                   20


<210> 13600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13600
agggtaagac ggaggaggaa                                                   20


<210> 13601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13601
gaagggtaag acggaggagg                                                   20


<210> 13602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13602
taggaagggt aagacggagg                                                   20


<210> 13603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13603
gtaggaaggg taagacggag                                                   20


<210> 13604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13604
tggtaggaag ggtaagacgg                                                   20


<210> 13605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13605
atggtaggaa gggtaagacg                                                   20


<210> 13606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13606
acatggtagg aagggtaaga                                                   20


<210> 13607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13607
gataacatgg taggaagggt                                                   20


<210> 13608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13608
caaagataac atggtaggaa                                                   20


<210> 13609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13609
gcaaagataa catggtagga                                                   20


<210> 13610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13610
ggcaaagata acatggtagg                                                   20


<210> 13611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13611
ggaggcaaag ataacatggt                                                   20


<210> 13612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13612
cggaggcaaa gataacatgg                                                   20


<210> 13613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13613
aggcggaggc aaagataaca                                                   20


<210> 13614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13614
ggatattcta ggcggaggca                                                   20


<210> 13615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13615
caagaggata ttctaggcgg                                                   20


<210> 13616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13616
ccaagaggat attctaggcg                                                   20


<210> 13617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13617
gaccaagagg atattctagg                                                   20


<210> 13618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13618
gttgaccaag aggatattct                                                   20


<210> 13619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13619
ggttgaccaa gaggatattc                                                   20


<210> 13620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13620
gactgtggag gttgaccaag                                                   20


<210> 13621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13621
tgactgtgga ggttgaccaa                                                   20


<210> 13622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13622
tttgactgtg gaggttgacc                                                   20


<210> 13623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13623
agataagttt ttgactgtgg                                                   20


<210> 13624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13624
aagataagtt tttgactgtg                                                   20


<210> 13625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13625
agaagataag tttttgactg                                                   20


<210> 13626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13626
tgaacttggc tgcagaagat                                                   20


<210> 13627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13627
ccagctgaac ttggctgcag                                                   20


<210> 13628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13628
cttccagctg aacttggctg                                                   20


<210> 13629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13629
cagtcacttc cagctgaact                                                   20


<210> 13630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13630
gaataaactg cagtcacttc                                                   20


<210> 13631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13631
tgagcctgtg gaataaactg                                                   20


<210> 13632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13632
ggccaaagac tgtgagcctg                                                   20


<210> 13633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13633
aaaaacaggc caaagactgt                                                   20


<210> 13634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13634
tcataggaaa aaacaggcca                                                   20


<210> 13635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13635
tctgtgtcat aggaaaaaac                                                   20


<210> 13636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13636
gtctgtgtca taggaaaaaa                                                   20


<210> 13637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13637
aggagcaggg tctgtgtcat                                                   20


<210> 13638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13638
gaggagcagg gtctgtgtca                                                   20


<210> 13639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13639
tgcagtatca gggaggagca                                                   20


<210> 13640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13640
ctgcagtatc agggaggagc                                                   20


<210> 13641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13641
gctgcagtat cagggaggag                                                   20


<210> 13642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13642
aaggctgcag tatcagggag                                                   20


<210> 13643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13643
caaaggctgc agtatcaggg                                                   20


<210> 13644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13644
ccaaaggctg cagtatcagg                                                   20


<210> 13645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13645
acccaaaggc tgcagtatca                                                   20


<210> 13646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13646
gacccaaagg ctgcagtatc                                                   20


<210> 13647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13647
tgacccaaag gctgcagtat                                                   20


<210> 13648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13648
agggcatgac ccaaaggctg                                                   20


<210> 13649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13649
gaggaaaggg catgacccaa                                                   20


<210> 13650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13650
ggaggaaagg gcatgaccca                                                   20


<210> 13651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13651
caggaccagg gtggaggaaa                                                   20


<210> 13652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13652
acaggaccag ggtggaggaa                                                   20


<210> 13653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13653
cacaggacca gggtggagga                                                   20


<210> 13654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13654
agagcacagg accagggtgg                                                   20


<210> 13655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13655
cagagcacag gaccagggtg                                                   20


<210> 13656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13656
cacagagcac aggaccaggg                                                   20


<210> 13657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13657
cttcacagag cacaggacca                                                   20


<210> 13658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13658
ccttcacaga gcacaggacc                                                   20


<210> 13659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13659
gccttcacag agcacaggac                                                   20


<210> 13660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13660
tcctggcctt cacagagcac                                                   20


<210> 13661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13661
gtcctggcct tcacagagca                                                   20


<210> 13662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13662
aaggggtcct ggccttcaca                                                   20


<210> 13663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13663
ataaggggtc ctggccttca                                                   20


<210> 13664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13664
agaggaatca taaggggtcc                                                   20


<210> 13665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13665
gtagggagag gaatcataag                                                   20


<210> 13666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13666
ggtagggaga ggaatcataa                                                   20


<210> 13667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13667
aggtagggag aggaatcata                                                   20


<210> 13668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13668
gaggtaggga gaggaatcat                                                   20


<210> 13669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13669
tcacagtagg aggtagggag                                                   20


<210> 13670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13670
ttcacagtag gaggtaggga                                                   20


<210> 13671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13671
tcttcacagt aggaggtagg                                                   20


<210> 13672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13672
aatcttcaca gtaggaggta                                                   20


<210> 13673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13673
caatcttcac agtaggaggt                                                   20


<210> 13674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13674
tcaatcttca cagtaggagg                                                   20


<210> 13675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13675
gagtcaatct tcacagtagg                                                   20


<210> 13676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13676
agagtcaatc ttcacagtag                                                   20


<210> 13677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13677
acagagtcaa tcttcacagt                                                   20


<210> 13678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13678
aacagagtca atcttcacag                                                   20


<210> 13679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13679
agaaacagag tcaatcttca                                                   20


<210> 13680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13680
aggaccgggt gccagaaaca                                                   20


<210> 13681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13681
acaggaccgg gtgccagaaa                                                   20


<210> 13682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13682
ttagccacag gaccgggtgc                                                   20


<210> 13683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13683
gtacaattag ccacaggacc                                                   20


<210> 13684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13684
cgtacaatta gccacaggac                                                   20


<210> 13685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13685
ggctccgtac aattagccac                                                   20


<210> 13686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13686
aggctccgta caattagcca                                                   20


<210> 13687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13687
aacaccaggc tccgtacaat                                                   20


<210> 13688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13688
gcccccttgt aattaacacc                                                   20


<210> 13689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13689
ggcccccttg taattaacac                                                   20


<210> 13690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13690
agccagttgc ccgaatcctc                                                   20


<210> 13691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13691
cagccagttg cccgaatcct                                                   20


<210> 13692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13692
cttatgcttt agctgtcagc                                                   20


<210> 13693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13693
atcccttatg ctttagctgt                                                   20


<210> 13694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13694
cattcaaatc ccttatgctt                                                   20


<210> 13695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13695
taaggcattg tgcagacagc                                                   20


<210> 13696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13696
aaattaaggc attgtgcaga                                                   20


<210> 13697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13697
aaacaaatta aggcattgtg                                                   20


<210> 13698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13698
aaaaaaaaaa aaacaaatta                                                   20


<210> 13699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13699
aaaaaaaaaa aaaacaaatt                                                   20


<210> 13700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13700
acataaagtt caaaaacagc                                                   20


<210> 13701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13701
cctaacataa agttcaaaaa                                                   20


<210> 13702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13702
tatctccagg ccctaacata                                                   20


<210> 13703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13703
ccccaaaaaa acctatctcc                                                   20


<210> 13704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13704
cccccaaaaa aacctatctc                                                   20


<210> 13705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13705
ttcatagttg gagttggggg                                                   20


<210> 13706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13706
ttgttcatag ttggagttgg                                                   20


<210> 13707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13707
tttgttcata gttggagttg                                                   20


<210> 13708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13708
ctttgttcat agttggagtt                                                   20


<210> 13709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13709
actttgttca tagttggagt                                                   20


<210> 13710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13710
tccaactttg ttcatagttg                                                   20


<210> 13711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13711
tttccaactt tgttcatagt                                                   20


<210> 13712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13712
tatatttcca actttgttca                                                   20


<210> 13713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13713
caagttagac atcatataga                                                   20


<210> 13714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13714
tcaagttaga catcatatag                                                   20


<210> 13715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13715
ttcaagttag acatcatata                                                   20


<210> 13716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13716
tcttcaagtt agacatcata                                                   20


<210> 13717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13717
aaaatcaaac atcttcaagt                                                   20


<210> 13718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13718
accaaaaatc aaacatcttc                                                   20


<210> 13719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13719
ataaggctcc ccaggtcccc                                                   20


<210> 13720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13720
tggtacaaat aaggctcccc                                                   20


<210> 13721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13721
ttggtacaaa taaggctccc                                                   20


<210> 13722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13722
ggaggccttt ggtacaaata                                                   20


<210> 13723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13723
tggaggcctt tggtacaaat                                                   20


<210> 13724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13724
tcatctttgg tggaggcctt                                                   20


<210> 13725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13725
ccttgcctca tctttggtgg                                                   20


<210> 13726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13726
gccttgcctc atctttggtg                                                   20


<210> 13727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13727
aggccttgcc tcatctttgg                                                   20


<210> 13728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13728
taaaggcctt gcctcatctt                                                   20


<210> 13729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13729
ttgaaccctc tcttacctaa                                                   20


<210> 13730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13730
gttgaaccct ctcttaccta                                                   20


<210> 13731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13731
tccctcacca tttttcctgt                                                   20


<210> 13732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13732
gggaacctgg caaggagcga                                                   20


<210> 13733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13733
cagggaacct ggcaaggagc                                                   20


<210> 13734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13734
ggcccaggga acctggcaag                                                   20


<210> 13735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13735
agggcccagg gaacctggca                                                   20


<210> 13736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13736
gagggcccag ggaacctggc                                                   20


<210> 13737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13737
gggagagggc ccagggaacc                                                   20


<210> 13738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13738
caagtagggg agagggccca                                                   20


<210> 13739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13739
gcaagtaggg gagagggccc                                                   20


<210> 13740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13740
agcaagtagg ggagagggcc                                                   20


<210> 13741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13741
caaagagcaa gtaggggaga                                                   20


<210> 13742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13742
acaaagagca agtaggggag                                                   20


<210> 13743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13743
aacaaagagc aagtagggga                                                   20


<210> 13744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13744
acaacaaaga gcaagtaggg                                                   20


<210> 13745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13745
taacaacaaa gagcaagtag                                                   20


<210> 13746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13746
ataacaacaa agagcaagta                                                   20


<210> 13747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13747
cataacaaca aagagcaagt                                                   20


<210> 13748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13748
gcataacaac aaagagcaag                                                   20


<210> 13749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13749
tgtgcataac aacaaagagc                                                   20


<210> 13750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13750
cccatgtgca taacaacaaa                                                   20


<210> 13751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13751
gacccatgtg cataacaaca                                                   20


<210> 13752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13752
caaaattata attatttccc                                                   20


<210> 13753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13753
ttcacagaag gtcttccaca                                                   20


<210> 13754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13754
ttaaactgga aattcacaga                                                   20


<210> 13755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13755
gttaaactgg aaattcacag                                                   20


<210> 13756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13756
ctagttaaac tggaaattca                                                   20


<210> 13757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13757
ggaacatgtc ctagttaaac                                                   20


<210> 13758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13758
tacacgatgg gaacatgtcc                                                   20


<210> 13759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13759
aataatgtac cctacacgat                                                   20


<210> 13760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13760
aaataatgta ccctacacga                                                   20


<210> 13761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13761
gaaaatttta ccagagtatg                                                   20


<210> 13762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13762
tctggcagaa aattttacca                                                   20


<210> 13763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13763
tgtctggcag aaaattttac                                                   20


<210> 13764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13764
gctgtagacc agttgtctgg                                                   20


<210> 13765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13765
tgtgctgtag accagttgtc                                                   20


<210> 13766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13766
aattaaaatg tgctgtagac                                                   20


<210> 13767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13767
gagcaaatta aaatgtgctg                                                   20


<210> 13768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13768
tcccttaaaa taagatcctg                                                   20


<210> 13769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13769
tctcccttaa aataagatcc                                                   20


<210> 13770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13770
gaaccattct cccttaaaat                                                   20


<210> 13771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13771
atctaattgt tacaagtacg                                                   20


<210> 13772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13772
tatctaattg ttacaagtac                                                   20


<210> 13773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13773
attgagtatc taattgttac                                                   20


<210> 13774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13774
cccaccaaca agaggtgatt                                                   20


<210> 13775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13775
tcttctttcc caccaacaag                                                   20


<210> 13776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13776
ttcttctttc ccaccaacaa                                                   20


<210> 13777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13777
ctttcttctt tcccaccaac                                                   20


<210> 13778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13778
ttatagagct ggaaaataag                                                   20


<210> 13779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13779
cccttataga gctggaaaat                                                   20


<210> 13780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13780
gcaggaatcc cttatagagc                                                   20


<210> 13781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13781
tggggcagga atcccttata                                                   20


<210> 13782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13782
gctggggcag gaatccctta                                                   20


<210> 13783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13783
gtagcaccat ccgctggggc                                                   20


<210> 13784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13784
ggtagcacca tccgctgggg                                                   20


<210> 13785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13785
cagggtagca ccatccgctg                                                   20


<210> 13786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13786
acagggtagc accatccgct                                                   20


<210> 13787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13787
tacagggtag caccatccgc                                                   20


<210> 13788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13788
agttcctgtg gcttacaggg                                                   20


<210> 13789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13789
accagttcct gtggcttaca                                                   20


<210> 13790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13790
taccagttcc tgtggcttac                                                   20


<210> 13791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13791
ctaccagttc ctgtggctta                                                   20


<210> 13792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13792
atcttaacta ccagttcctg                                                   20


<210> 13793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13793
gatggggata tcttaactac                                                   20


<210> 13794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13794
aagtacttag ttctatgatg                                                   20


<210> 13795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13795
caagtactta gttctatgat                                                   20


<210> 13796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13796
ccaagtactt agttctatga                                                   20


<210> 13797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13797
ataaaacata gccaagtact                                                   20


<210> 13798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13798
tatagaaata aaacatagcc                                                   20


<210> 13799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13799
agtaatatag aaataaaaca                                                   20


<210> 13800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13800
ttgtttgtgt atcagtaata                                                   20


<210> 13801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13801
aagggagctt gtttgtgtat                                                   20


<210> 13802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13802
tgattttata ttaaagaagg                                                   20


<210> 13803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13803
tttgatttta tattaaagaa                                                   20


<210> 13804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13804
ttttgatttt atattaaaga                                                   20


<210> 13805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13805
attttgattt tatattaaag                                                   20


<210> 13806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13806
gctattttga ttttatatta                                                   20


<210> 13807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13807
tccaaaatga aagattccaa                                                   20


<210> 13808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13808
ttccaaaatg aaagattcca                                                   20


<210> 13809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13809
ttgtttgtct tccaaaatga                                                   20


<210> 13810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13810
gtttttgttg gttggttggt                                                   20


<210> 13811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13811
aggagttttt gttggttggt                                                   20


<210> 13812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13812
taataggagt ttttgttggt                                                   20


<210> 13813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13813
agcataatag gagtttttgt                                                   20


<210> 13814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13814
tatctcactt agcataatag                                                   20


<210> 13815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13815
cttatctcac ttagcataat                                                   20


<210> 13816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13816
gcttatctca cttagcataa                                                   20


<210> 13817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13817
tgtgtctggc ttatctcact                                                   20


<210> 13818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13818
cgtttttgtc cttctgtgtc                                                   20


<210> 13819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13819
tcccatgagt ttgactattt                                                   20


<210> 13820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13820
attctattct ctgctcccat                                                   20


<210> 13821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13821
tttcccctcc tcccagctcc                                                   20


<210> 13822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13822
tccccaattt cccctcctcc                                                   20


<210> 13823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13823
ggaagtttgt acactttgac                                                   20


<210> 13824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13824
tattcatgtc acataactgg                                                   20


<210> 13825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13825
atttattcat gtcacataac                                                   20


<210> 13826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13826
tatgctataa gtagagctct                                                   20


<210> 13827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13827
ctatgctata agtagagctc                                                   20


<210> 13828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13828
tagggactat gctataagta                                                   20


<210> 13829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13829
tatagggact atgctataag                                                   20


<210> 13830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13830
aactataggg actatgctat                                                   20


<210> 13831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13831
acacggtatt gctaactata                                                   20


<210> 13832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13832
aacacggtat tgctaactat                                                   20


<210> 13833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13833
caacacggta ttgctaacta                                                   20


<210> 13834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13834
aaatttttag gtagacaaca                                                   20


<210> 13835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13835
tctcttggca aatttttagg                                                   20


<210> 13836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13836
tattctcttg gcaaattttt                                                   20


<210> 13837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13837
ttattctctt ggcaaatttt                                                   20


<210> 13838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13838
acacttaaga tttattctct                                                   20


<210> 13839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13839
attgggtgct aggaacactt                                                   20


<210> 13840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13840
ttatttattt attgggtgct                                                   20


<210> 13841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13841
tttatttatt tattgggtgc                                                   20


<210> 13842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13842
tgcctattta tttatttatt                                                   20


<210> 13843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13843
ctgcctattt atttatttat                                                   20


<210> 13844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13844
accatcacca ccatcaatgc                                                   20


<210> 13845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13845
aactttatga gtttggagat                                                   20


<210> 13846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13846
tacacaactt tatgagtttg                                                   20


<210> 13847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13847
tgtacacaac tttatgagtt                                                   20


<210> 13848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13848
tttaatgtac acaactttat                                                   20


<210> 13849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13849
aggtatgatc cacatgtaaa                                                   20


<210> 13850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13850
tgttttttaa cactttattg                                                   20


<210> 13851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13851
ctgtttttta acactttatt                                                   20


<210> 13852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13852
gcgtgtattt ccggggattt                                                   20


<210> 13853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13853
ttgggttgcg tgtatttccg                                                   20


<210> 13854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13854
cttgggttgc gtgtatttcc                                                   20


<210> 13855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13855
ccttgggttg cgtgtatttc                                                   20


<210> 13856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13856
tggtgctgaa acacagcctt                                                   20


<210> 13857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13857
ttggtgctga aacacagcct                                                   20


<210> 13858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13858
cccaccttgg tgctgaaaca                                                   20


<210> 13859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13859
tttcatcaac ctccccacct                                                   20


<210> 13860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13860
agtatctaaa tacaacttaa                                                   20


<210> 13861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13861
gatttagtaa caagagctga                                                   20


<210> 13862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13862
ctgatttagt aacaagagct                                                   20


<210> 13863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13863
tgccactgat ttagtaacaa                                                   20


<210> 13864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13864
tttgccactg atttagtaac                                                   20


<210> 13865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13865
gatttaattt gccactgatt                                                   20


<210> 13866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13866
ttcatgtcgg ggtgtagctg                                                   20


<210> 13867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13867
ttacttttca tgtcggggtg                                                   20


<210> 13868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13868
cctgcttact tttcatgtcg                                                   20


<210> 13869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13869
acctgcttac ttttcatgtc                                                   20


<210> 13870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 13870
gacctgctta cttttcatgt                                                   20


<210> 13871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13871
cattataaat gtatcttgat                                                   20


<210> 13872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13872
tcatgctcac cagcttcacc                                                   20


<210> 13873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13873
aaaggccaaa tcatgctcac                                                   20


<210> 13874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13874
gctgaagttt gaccctataa                                                   20


<210> 13875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13875
agctgaagtt tgaccctata                                                   20


<210> 13876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13876
ctgggcttat gggttagctg                                                   20


<210> 13877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13877
ctgtccctgg gcttatgggt                                                   20


<210> 13878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13878
gagactgtcc ctgggcttat                                                   20


<210> 13879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13879
agagactgtc cctgggctta                                                   20


<210> 13880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13880
acagccaaga gactgtccct                                                   20


<210> 13881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13881
aacagccaag agactgtccc                                                   20


<210> 13882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13882
tgcctgtcac caacagccaa                                                   20


<210> 13883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13883
gctgcctgtc accaacagcc                                                   20


<210> 13884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13884
aacttgctgc ctgtcaccaa                                                   20


<210> 13885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13885
gttgaagctg agtttagaac                                                   20


<210> 13886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13886
ggttgaagct gagtttagaa                                                   20


<210> 13887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13887
ccaagggttg aagctgagtt                                                   20


<210> 13888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13888
agtttccaag ggttgaagct                                                   20


<210> 13889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13889
cacagagttt ccaagggttg                                                   20


<210> 13890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13890
cagggtcaca gagtttccaa                                                   20


<210> 13891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13891
gcagggtcac agagtttcca                                                   20


<210> 13892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13892
tgcagggtca cagagtttcc                                                   20


<210> 13893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13893
gaatattatg cagggtcaca                                                   20


<210> 13894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13894
aagaatatta tgcagggtca                                                   20


<210> 13895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13895
gagatcaaga atattatgca                                                   20


<210> 13896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13896
agagatcaag aatattatgc                                                   20


<210> 13897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13897
cagagatcaa gaatattatg                                                   20


<210> 13898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13898
aaaattgaga ctcagagatc                                                   20


<210> 13899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13899
acatttaaaa ttgagactca                                                   20


<210> 13900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13900
atacatttaa aattgagact                                                   20


<210> 13901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13901
tattttatac atttaaaatt                                                   20


<210> 13902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13902
tcacagcagc cctgtcaagc                                                   20


<210> 13903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13903
ttcacagcag ccctgtcaag                                                   20


<210> 13904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13904
atgttcacag cagccctgtc                                                   20


<210> 13905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13905
ggctccatga atgttcacag                                                   20


<210> 13906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13906
ctgggctcca tgaatgttca                                                   20


<210> 13907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13907
taagttctga gcactgagct                                                   20


<210> 13908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13908
ctaagttctg agcactgagc                                                   20


<210> 13909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13909
cttcctaagt tctgagcact                                                   20


<210> 13910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13910
ctgaatactt cctaagttct                                                   20


<210> 13911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13911
gccttgactg aatacttcct                                                   20


<210> 13912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13912
gaggctaaca tggggaaatg                                                   20


<210> 13913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13913
tagaggctaa catggggaaa                                                   20


<210> 13914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13914
tagagttaga ggctaacatg                                                   20


<210> 13915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13915
ctagagttag aggctaacat                                                   20


<210> 13916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13916
actagagtta gaggctaaca                                                   20


<210> 13917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13917
gagaaaatta ctagagttag                                                   20


<210> 13918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13918
agagaaaatt actagagtta                                                   20


<210> 13919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13919
tcagagaaaa ttactagagt                                                   20


<210> 13920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13920
gtgttcagag aaaattacta                                                   20


<210> 13921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13921
tggtgttcag agaaaattac                                                   20


<210> 13922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13922
tttgggtcca gtggtgttca                                                   20


<210> 13923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13923
attttgggtc cagtggtgtt                                                   20


<210> 13924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13924
gcccagtatt ttgggtccag                                                   20


<210> 13925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13925
caggcccagt attttgggtc                                                   20


<210> 13926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13926
aatgacaggc ccagtatttt                                                   20


<210> 13927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13927
gaatgacagg cccagtattt                                                   20


<210> 13928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13928
gtgttgttga atgacaggcc                                                   20


<210> 13929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13929
tctgggtgtt gttgaatgac                                                   20


<210> 13930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13930
gtctgggtgt tgttgaatga                                                   20


<210> 13931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13931
atactgttaa ggcccagtct                                                   20


<210> 13932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13932
aatactgtta aggcccagtc                                                   20


<210> 13933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13933
aaattaatac tgttaaggcc                                                   20


<210> 13934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13934
ccaagaaatt aatactgtta                                                   20


<210> 13935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13935
gccaagaaat taatactgtt                                                   20


<210> 13936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13936
aaagtcaaga tatcaatgcc                                                   20


<210> 13937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13937
acatgagtga tagaaaagtc                                                   20


<210> 13938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13938
agggaacatg agtgatagaa                                                   20


<210> 13939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13939
ctattaggga acatgagtga                                                   20


<210> 13940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13940
actgttctat tagggaacat                                                   20


<210> 13941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13941
tctacacaac tgttctatta                                                   20


<210> 13942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13942
ctctacacaa ctgttctatt                                                   20


<210> 13943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13943
tctctacaca actgttctat                                                   20


<210> 13944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13944
agattctcaa gtctagggtc                                                   20


<210> 13945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13945
aaaggagatt ctcaagtcta                                                   20


<210> 13946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13946
caaaggagat tctcaagtct                                                   20


<210> 13947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13947
tcaaaggaga ttctcaagtc                                                   20


<210> 13948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13948
attgttcaaa ggagattctc                                                   20


<210> 13949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13949
tgggaggaga ttgttcaaag                                                   20


<210> 13950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13950
actgggagga gattgttcaa                                                   20


<210> 13951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13951
gactgggagg agattgttca                                                   20


<210> 13952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13952
aagtgaggaa agactgggag                                                   20


<210> 13953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13953
caaagtgagg aaagactggg                                                   20


<210> 13954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13954
tcaaagtgag gaaagactgg                                                   20


<210> 13955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13955
catcaaagtg aggaaagact                                                   20


<210> 13956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13956
ccatcaaagt gaggaaagac                                                   20


<210> 13957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13957
gattgccatc aaagtgagga                                                   20


<210> 13958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13958
gatggattgc catcaaagtg                                                   20


<210> 13959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13959
agatggattg ccatcaaagt                                                   20


<210> 13960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13960
aaggagatgg attgccatca                                                   20


<210> 13961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13961
atctgttctg gaaaaggaga                                                   20


<210> 13962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13962
taaaatctgt tctggaaaag                                                   20


<210> 13963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13963
cttaaaatct gttctggaaa                                                   20


<210> 13964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13964
tcttaaaatc tgttctggaa                                                   20


<210> 13965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13965
atgagtctta aaatctgttc                                                   20


<210> 13966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13966
caggtggtgt aatgtgagat                                                   20


<210> 13967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13967
gggggcaggt ggtgtaatgt                                                   20


<210> 13968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13968
tcttgaaagc agggggcagg                                                   20


<210> 13969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13969
tggtcttgaa agcagggggc                                                   20


<210> 13970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13970
atggtcttga aagcaggggg                                                   20


<210> 13971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13971
tttatggtct tgaaagcagg                                                   20


<210> 13972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13972
ttttatggtc ttgaaagcag                                                   20


<210> 13973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13973
cttttatggt cttgaaagca                                                   20


<210> 13974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13974
acttttatgg tcttgaaagc                                                   20


<210> 13975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13975
tacttttatg gtcttgaaag                                                   20


<210> 13976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13976
ccttactttt atggtcttga                                                   20


<210> 13977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13977
tccagcagac cttactttta                                                   20


<210> 13978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13978
taagatgatg gagtctccag                                                   20


<210> 13979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13979
ccgtaagatg atggagtctc                                                   20


<210> 13980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13980
cctcagaccg taagatgatg                                                   20


<210> 13981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13981
aacctcagac cgtaagatga                                                   20


<210> 13982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13982
tcctgagaac ctcagaccgt                                                   20


<210> 13983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13983
atcactcctc ctgagaacct                                                   20


<210> 13984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 13984
agggaataat cactcctcct                                                   20


<210> 13985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13985
tagaacctca ggggctgaca                                                   20


<210> 13986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13986
ctagaacctc aggggctgac                                                   20


<210> 13987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13987
gctagaacct caggggctga                                                   20


<210> 13988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13988
gcccatggct agaacctcag                                                   20


<210> 13989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 13989
agcccatggc tagaacctca                                                   20


<210> 13990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13990
cagcccatgg ctagaacctc                                                   20


<210> 13991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13991
acagcccatg gctagaacct                                                   20


<210> 13992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 13992
ctgtgtgcac agcccatggc                                                   20


<210> 13993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13993
cctactgtgt gcacagccca                                                   20


<210> 13994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13994
tcaggcacct actgtgtgca                                                   20


<210> 13995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13995
tgctcacacg aagtgttttc                                                   20


<210> 13996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 13996
atgctcacac gaagtgtttt                                                   20


<210> 13997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 13997
gccttctcca tgctcacacg                                                   20


<210> 13998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 13998
gtgaaatgaa gaggttctct                                                   20


<210> 13999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 13999
gctctctcag tgaaatgaag                                                   20


<210> 14000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14000
tgctctctca gtgaaatgaa                                                   20


<210> 14001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14001
gctgctctct cagtgaaatg                                                   20


<210> 14002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14002
aatgccttgg gctgctctct                                                   20


<210> 14003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14003
tagcaagttt taaatgcctt                                                   20


<210> 14004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14004
gtagcaagtt ttaaatgcct                                                   20


<210> 14005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14005
tgcagctttc caagagtagc                                                   20


<210> 14006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14006
tatttgcagc tttccaagag                                                   20


<210> 14007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14007
ctgtatttgc agctttccaa                                                   20


<210> 14008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14008
ccctgtattt gcagctttcc                                                   20


<210> 14009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14009
ttagaagaac cctgtatttg                                                   20


<210> 14010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14010
gaaatacgtg tttatgttag                                                   20


<210> 14011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14011
tttgaaatac gtgtttatgt                                                   20


<210> 14012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14012
gggatgctct tctaaaacca                                                   20


<210> 14013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14013
tgggatgctc ttctaaaacc                                                   20


<210> 14014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14014
acctctgttt gggggtcttt                                                   20


<210> 14015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14015
cacctctgtt tgggggtctt                                                   20


<210> 14016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14016
gaagccccac ctctgtttgg                                                   20


<210> 14017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14017
ggaagcccca cctctgtttg                                                   20


<210> 14018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14018
gggaagcccc acctctgttt                                                   20


<210> 14019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14019
ggggaagccc cacctctgtt                                                   20


<210> 14020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14020
tgggcagcca cgtggtgggg                                                   20


<210> 14021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14021
aagtgggcag ccacgtggtg                                                   20


<210> 14022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14022
taagtgggca gccacgtggt                                                   20


<210> 14023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14023
gtaagtgggc agccacgtgg                                                   20


<210> 14024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14024
cgagtaagtg ggcagccacg                                                   20


<210> 14025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14025
ctccattgcg agtaagtggg                                                   20


<210> 14026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14026
tctctccatt gcgagtaagt                                                   20


<210> 14027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14027
ttctctccat tgcgagtaag                                                   20


<210> 14028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14028
tggttctctc cattgcgagt                                                   20


<210> 14029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14029
gtggtggttc tctccattgc                                                   20


<210> 14030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14030
tgtgtttgac ttcattgtgg                                                   20


<210> 14031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14031
gaatgtgttt gacttcattg                                                   20


<210> 14032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14032
agtactactt cacaaatggc                                                   20


<210> 14033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14033
aggcagtact acttcacaaa                                                   20


<210> 14034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14034
tgaagatgtt cgctttgagg                                                   20


<210> 14035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14035
tcatgaagat gttcgctttg                                                   20


<210> 14036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14036
gtcatgaaga tgttcgcttt                                                   20


<210> 14037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14037
tcacaggcga atgtgtcatg                                                   20


<210> 14038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14038
ttctttgtgg ccgtcttcac                                                   20


<210> 14039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14039
gttctttgtg gccgtcttca                                                   20


<210> 14040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14040
caaaatcaac cagttctttg                                                   20


<210> 14041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14041
aaattctggg caaaatcaac                                                   20


<210> 14042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14042
gaagaaaaga cgaaaattct                                                   20


<210> 14043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14043
tgaagaaaag acgaaaattc                                                   20


<210> 14044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14044
ctgatgacca aagtgaagaa                                                   20


<210> 14045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14045
ggagactgat gaccaaagtg                                                   20


<210> 14046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14046
atggtggaga ctgatgacca                                                   20


<210> 14047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14047
acatgatcac catgatggtg                                                   20


<210> 14048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14048
caacatgatc accatgatgg                                                   20


<210> 14049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14049
cctcaacatg atcaccatga                                                   20


<210> 14050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14050
agcttttgac atcaccatca                                                   20


<210> 14051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14051
ctttgacatc gtgaccagac                                                   20


<210> 14052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14052
tttgtctttg acatcgtgac                                                   20


<210> 14053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14053
ttttctcaga acaagttcca                                                   20


<210> 14054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14054
gttttctcag aacaagttcc                                                   20


<210> 14055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14055
tgttttctca gaacaagttc                                                   20


<210> 14056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14056
atctcttgtt ttctcagaac                                                   20


<210> 14057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14057
gccactatct cttgttttct                                                   20


<210> 14058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14058
cctggtttgt gctggcccaa                                                   20


<210> 14059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14059
gcctggtttg tgctggccca                                                   20


<210> 14060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14060
cacagatgcc tggtttgtgc                                                   20


<210> 14061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14061
ctacagataa cacagatgcc                                                   20


<210> 14062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14062
aaactcatct acagataaca                                                   20


<210> 14063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14063
atggagacaa aactcatcta                                                   20


<210> 14064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14064
ttaagatgtg gagtgtgatg                                                   20


<210> 14065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14065
tgttaagatg tggagtgtga                                                   20


<210> 14066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14066
ttcgcttctg ttaagatgtg                                                   20


<210> 14067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14067
atttcgcttc tgttaagatg                                                   20


<210> 14068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14068
gatagtattt cgcttctgtt                                                   20


<210> 14069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14069
aattttggaa gaggtaagga                                                   20


<210> 14070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14070
gtgaaatttt ggaagaggta                                                   20


<210> 14071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14071
agtgaaattt tggaagaggt                                                   20


<210> 14072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14072
taaaagtgaa attttggaag                                                   20


<210> 14073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14073
ctaaaagtga aattttggaa                                                   20


<210> 14074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14074
aactaaaagt gaaattttgg                                                   20


<210> 14075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14075
gtcaactaaa agtgaaattt                                                   20


<210> 14076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14076
aatgaggtag agtcaactaa                                                   20


<210> 14077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14077
tgaactgggg caatgaggta                                                   20


<210> 14078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14078
cttgaactgg ggcaatgagg                                                   20


<210> 14079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14079
ggacttgaac tggggcaatg                                                   20


<210> 14080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14080
aggacttgaa ctggggcaat                                                   20


<210> 14081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14081
ggtattaagg acttgaactg                                                   20


<210> 14082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14082
aggtattaag gacttgaact                                                   20


<210> 14083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14083
gaggtattaa ggacttgaac                                                   20


<210> 14084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14084
aagggccagg agaggtatta                                                   20


<210> 14085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14085
aaagggccag gagaggtatt                                                   20


<210> 14086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14086
tggcatcaaa gggccaggag                                                   20


<210> 14087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14087
gtggcatcaa agggccagga                                                   20


<210> 14088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14088
tggtggcatc aaagggccag                                                   20


<210> 14089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14089
cctggtggca tcaaagggcc                                                   20


<210> 14090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14090
gcctggtggc atcaaagggc                                                   20


<210> 14091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14091
aagggcctgg tggcatcaaa                                                   20


<210> 14092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14092
gaagggcctg gtggcatcaa                                                   20


<210> 14093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14093
agaagggcct ggtggcatca                                                   20


<210> 14094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14094
aggacaaaag aagggcctgg                                                   20


<210> 14095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14095
accaggacaa aagaagggcc                                                   20


<210> 14096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14096
cacagaccag gacaaaagaa                                                   20


<210> 14097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14097
gcacagacca ggacaaaaga                                                   20


<210> 14098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14098
ggcacagacc aggacaaaag                                                   20


<210> 14099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14099
aagggcacag accaggacaa                                                   20


<210> 14100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14100
tagaggcaag ggcacagacc                                                   20


<210> 14101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14101
atagaggcaa gggcacagac                                                   20


<210> 14102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14102
tgtgaataga ggcaagggca                                                   20


<210> 14103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14103
ggcattgtga atagaggcaa                                                   20


<210> 14104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14104
gggcattgtg aatagaggca                                                   20


<210> 14105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14105
agggcattgt gaatagaggc                                                   20


<210> 14106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14106
taggagggca ttgtgaatag                                                   20


<210> 14107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14107
ataggagggc attgtgaata                                                   20


<210> 14108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14108
agataggagg gcattgtgaa                                                   20


<210> 14109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14109
agccaagaga ggagatagga                                                   20


<210> 14110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14110
cagccaagag aggagatagg                                                   20


<210> 14111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14111
acagccaaga gaggagatag                                                   20


<210> 14112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14112
agacagccaa gagaggagat                                                   20


<210> 14113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14113
tagacagcca agagaggaga                                                   20


<210> 14114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14114
aatttagaca gccaagagag                                                   20


<210> 14115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14115
ggaatttaga cagccaagag                                                   20


<210> 14116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14116
tggaatttag acagccaaga                                                   20


<210> 14117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14117
gttggaattt agacagccaa                                                   20


<210> 14118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14118
ctgttggaat ttagacagcc                                                   20


<210> 14119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14119
caagactgtt ggaatttaga                                                   20


<210> 14120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14120
tactcaagac tgttggaatt                                                   20


<210> 14121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14121
gatggattac tcaagactgt                                                   20


<210> 14122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14122
ttaaaagaga tggattactc                                                   20


<210> 14123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14123
taagtggagc ttaaaagaga                                                   20


<210> 14124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14124
gcagtaagtg gagcttaaaa                                                   20


<210> 14125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14125
atgcagtaag tggagcttaa                                                   20


<210> 14126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14126
gacactccat gcagtaagtg                                                   20


<210> 14127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14127
gggacactcc atgcagtaag                                                   20


<210> 14128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14128
taagggacac tccatgcagt                                                   20


<210> 14129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14129
tgactaaggg acactccatg                                                   20


<210> 14130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14130
gtgtgttgtc acgtgactaa                                                   20


<210> 14131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14131
agtgtgttgt cacgtgacta                                                   20


<210> 14132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14132
tagtgtgttg tcacgtgact                                                   20


<210> 14133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14133
ggatccccaa agggacaggg                                                   20


<210> 14134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14134
gtgggatccc caaagggaca                                                   20


<210> 14135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14135
agtgggatcc ccaaagggac                                                   20


<210> 14136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14136
aagtgggatc cccaaaggga                                                   20


<210> 14137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14137
tgaaaagtgg gatccccaaa                                                   20


<210> 14138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14138
ctgaaaagtg ggatccccaa                                                   20


<210> 14139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14139
actgaaaagt gggatcccca                                                   20


<210> 14140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14140
ctcgaggctg actgaaaagt                                                   20


<210> 14141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14141
actcgaggct gactgaaaag                                                   20


<210> 14142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14142
agaactcgag gctgactgaa                                                   20


<210> 14143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14143
atacaaaatg ctagaactcg                                                   20


<210> 14144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14144
tatacaaaat gctagaactc                                                   20


<210> 14145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14145
aagacgcata tacaaaatgc                                                   20


<210> 14146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14146
cagctcattg tctagtagag                                                   20


<210> 14147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14147
aaacagctca ttgtctagta                                                   20


<210> 14148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14148
tcaaacagct cattgtctag                                                   20


<210> 14149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14149
tcctcaaaca gctcattgtc                                                   20


<210> 14150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14150
gtatagccct tgtcctcaaa                                                   20


<210> 14151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14151
aaacaaagtt aaggaaggta                                                   20


<210> 14152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14152
cagggaaaca aagttaagga                                                   20


<210> 14153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14153
gcagggaaac aaagttaagg                                                   20


<210> 14154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14154
actgcaggga aacaaagtta                                                   20


<210> 14155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14155
cactgcaggg aaacaaagtt                                                   20


<210> 14156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14156
cagggcactg cagggaaaca                                                   20


<210> 14157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14157
gcaatgtgca gggcactgca                                                   20


<210> 14158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14158
tgcaatgtgc agggcactgc                                                   20


<210> 14159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14159
ttgcaatgtg cagggcactg                                                   20


<210> 14160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14160
ttgaactctt gcaatgtgca                                                   20


<210> 14161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14161
cttgaactct tgcaatgtgc                                                   20


<210> 14162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14162
tcttgaactc ttgcaatgtg                                                   20


<210> 14163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14163
gctcaaatta atatttcaag                                                   20


<210> 14164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14164
gtagctcaaa ttaatatttc                                                   20


<210> 14165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14165
tgactttact ctcagcaaag                                                   20


<210> 14166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14166
acttgacttt actctcagca                                                   20


<210> 14167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14167
tttgcacttg actttactct                                                   20


<210> 14168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14168
gagggaacat ttccaagaat                                                   20


<210> 14169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14169
ggaacagagg gaacatttcc                                                   20


<210> 14170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14170
tgcacagcac caggaacaga                                                   20


<210> 14171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14171
ttgcacagca ccaggaacag                                                   20


<210> 14172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14172
tttgcacagc accaggaaca                                                   20


<210> 14173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14173
catttgcaca gcaccaggaa                                                   20


<210> 14174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14174
ttaggcattt gcacagcacc                                                   20


<210> 14175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14175
cttaggcatt tgcacagcac                                                   20


<210> 14176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14176
catttgctta ggcatttgca                                                   20


<210> 14177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14177
ccctatacct gcatttgctt                                                   20


<210> 14178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14178
gccctatacc tgcatttgct                                                   20


<210> 14179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14179
cttccaagat gcaaacaacc                                                   20


<210> 14180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14180
aggccactct gcctccttcc                                                   20


<210> 14181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14181
aaatgatctc ttggttatcc                                                   20


<210> 14182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14182
taaatgatct cttggttatc                                                   20


<210> 14183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14183
accagatata aatgatctct                                                   20


<210> 14184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14184
aaagacacca taaaaataac                                                   20


<210> 14185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14185
atcacagtag gagcttttta                                                   20


<210> 14186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14186
agaagagaag atcacagtag                                                   20


<210> 14187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14187
aaagaagaga agatcacagt                                                   20


<210> 14188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14188
aaaagaagag aagatcacag                                                   20


<210> 14189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14189
actaaaagaa gagaagatca                                                   20


<210> 14190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14190
tcacagcact aaaagaagag                                                   20


<210> 14191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14191
tgttcacagc actaaaagaa                                                   20


<210> 14192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14192
gatgttcaca gcactaaaag                                                   20


<210> 14193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14193
taagatgttc acagcactaa                                                   20


<210> 14194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14194
acagagcagt aagatgttca                                                   20


<210> 14195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14195
tcaaggactc acagagcagt                                                   20


<210> 14196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14196
gggatcaagg actcacagag                                                   20


<210> 14197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14197
gttgggatca aggactcaca                                                   20


<210> 14198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14198
gggttgggat caaggactca                                                   20


<210> 14199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14199
ggggaatggg gttgggatca                                                   20


<210> 14200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14200
tggggaatgg ggttgggatc                                                   20


<210> 14201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14201
aaagcgtggg gaatggggtt                                                   20


<210> 14202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14202
caaagcgtgg ggaatggggt                                                   20


<210> 14203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14203
aggtcaaagc gtggggaatg                                                   20


<210> 14204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14204
aaggtcaaag cgtggggaat                                                   20


<210> 14205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14205
gaaggtcaaa gcgtggggaa                                                   20


<210> 14206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14206
tgggagaagg tcaaagcgtg                                                   20


<210> 14207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14207
ttgggagaag gtcaaagcgt                                                   20


<210> 14208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14208
tttgggagaa ggtcaaagcg                                                   20


<210> 14209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14209
gaagttttgg gagaaggtca                                                   20


<210> 14210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14210
tcaggagaag ttttgggaga                                                   20


<210> 14211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14211
gtcaggagaa gttttgggag                                                   20


<210> 14212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14212
gaggtcagga gaagttttgg                                                   20


<210> 14213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14213
tagaggtcag gagaagtttt                                                   20


<210> 14214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14214
atagaggtca ggagaagttt                                                   20


<210> 14215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14215
agctccatag aggtcaggag                                                   20


<210> 14216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14216
gtgagctcca tagaggtcag                                                   20


<210> 14217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14217
aggtgagctc catagaggtc                                                   20


<210> 14218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14218
caggtgagct ccatagaggt                                                   20


<210> 14219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14219
aaggcaggtg agctccatag                                                   20


<210> 14220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14220
caaggcaggt gagctccata                                                   20


<210> 14221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14221
atcaaggcag gtgagctcca                                                   20


<210> 14222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14222
atgtgcagat caaggcaggt                                                   20


<210> 14223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14223
agatatgtgc agatcaaggc                                                   20


<210> 14224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14224
gagatatgtg cagatcaagg                                                   20


<210> 14225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14225
ggggagatat gtgcagatca                                                   20


<210> 14226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14226
gggggagata tgtgcagatc                                                   20


<210> 14227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14227
tgaatagggg gagatatgtg                                                   20


<210> 14228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14228
tggcagcctt tgaatagggg                                                   20


<210> 14229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14229
aatggcagcc tttgaatagg                                                   20


<210> 14230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14230
gaatggcagc ctttgaatag                                                   20


<210> 14231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14231
agaatggcag cctttgaata                                                   20


<210> 14232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14232
gagaatggca gcctttgaat                                                   20


<210> 14233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14233
ggagaatggc agcctttgaa                                                   20


<210> 14234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14234
catggggtag gggagaatgg                                                   20


<210> 14235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14235
gtacatgggg taggggagaa                                                   20


<210> 14236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14236
ctgaggtaca tggggtaggg                                                   20


<210> 14237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14237
ccctgaggta catggggtag                                                   20


<210> 14238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14238
cccctgaggt acatggggta                                                   20


<210> 14239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14239
acccctgagg tacatggggt                                                   20


<210> 14240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14240
aacccctgag gtacatgggg                                                   20


<210> 14241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14241
cctaacccct gaggtacatg                                                   20


<210> 14242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14242
gcctaacccc tgaggtacat                                                   20


<210> 14243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14243
ggcctaaccc ctgaggtaca                                                   20


<210> 14244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14244
aacgccaggc ctaacccctg                                                   20


<210> 14245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14245
gaacgccagg cctaacccct                                                   20


<210> 14246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14246
tggtgaacaa ggagaacgcc                                                   20


<210> 14247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14247
gtggtgaaca aggagaacgc                                                   20


<210> 14248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14248
aagggtcagt ggtgaacaag                                                   20


<210> 14249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14249
ggaagggtca gtggtgaaca                                                   20


<210> 14250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14250
tggaagggtc agtggtgaac                                                   20


<210> 14251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14251
cagtggtgtg gaagggtcag                                                   20


<210> 14252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14252
gagcagtggt gtggaagggt                                                   20


<210> 14253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14253
ggaagagcag tggtgtggaa                                                   20


<210> 14254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14254
aggaagagca gtggtgtgga                                                   20


<210> 14255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14255
caggaagagc agtggtgtgg                                                   20


<210> 14256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14256
acacaggaag agcagtggtg                                                   20


<210> 14257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14257
acaagacaca ggaagagcag                                                   20


<210> 14258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14258
tttacaagac acaggaagag                                                   20


<210> 14259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14259
ggttttacaa gacacaggaa                                                   20


<210> 14260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14260
ggggttttac aagacacagg                                                   20


<210> 14261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14261
gaaggggttt tacaagacac                                                   20


<210> 14262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14262
agaaggggtt ttacaagaca                                                   20


<210> 14263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14263
aaagcaagaa ggggttttac                                                   20


<210> 14264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14264
caaagcttca aagcaagaag                                                   20


<210> 14265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14265
gcaaagcttc aaagcaagaa                                                   20


<210> 14266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14266
ggcaaagctt caaagcaaga                                                   20


<210> 14267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14267
tggcaaagct tcaaagcaag                                                   20


<210> 14268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14268
aggtggcaaa gcttcaaagc                                                   20


<210> 14269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14269
aactaggtgg caaagcttca                                                   20


<210> 14270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14270
agtgacaaaa ctaggtggca                                                   20


<210> 14271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14271
gaagaagtga caaaactagg                                                   20


<210> 14272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14272
aatgaagaag tgacaaaact                                                   20


<210> 14273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14273
taatgaagaa gtgacaaaac                                                   20


<210> 14274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14274
ggcaagcggc agtaatgaag                                                   20


<210> 14275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14275
tttggcaagc ggcagtaatg                                                   20


<210> 14276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14276
accaagagtt tggcaagcgg                                                   20


<210> 14277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 14277
gggaccaaga gtttggcaag                                                   20


<210> 14278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14278
agagggacca agagtttggc                                                   20


<210> 14279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14279
aggcagaggg accaagagtt                                                   20


<210> 14280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14280
tactgaggca gagggaccaa                                                   20


<210> 14281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14281
attactgagg cagagggacc                                                   20


<210> 14282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14282
cccatcatta ctgaggcaga                                                   20


<210> 14283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14283
acccatcatt actgaggcag                                                   20


<210> 14284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14284
cacccatcat tactgaggca                                                   20


<210> 14285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14285
ctcacccatc attactgagg                                                   20


<210> 14286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14286
agcctcaccc atcattactg                                                   20


<210> 14287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14287
gagcctcacc catcattact                                                   20


<210> 14288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14288
gagtgggcaa atatggccaa                                                   20


<210> 14289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14289
aagagtgggc aaatatggcc                                                   20


<210> 14290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14290
tagccaagag tgggcaaata                                                   20


<210> 14291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14291
ctaggataat agccaagagt                                                   20


<210> 14292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14292
cctaggataa tagccaagag                                                   20


<210> 14293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14293
ttgcctagga taatagccaa                                                   20


<210> 14294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14294
tgttgcctag gataatagcc                                                   20


<210> 14295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14295
attaatgttg cctaggataa                                                   20


<210> 14296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14296
catggacatt aatgttgcct                                                   20


<210> 14297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14297
acatggacat taatgttgcc                                                   20


<210> 14298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14298
gagacaaaga gtaatgcaca                                                   20


<210> 14299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14299
gcaataaacc aagagacaaa                                                   20


<210> 14300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14300
gtgcaataaa ccaagagaca                                                   20


<210> 14301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14301
agatttgtgc aataaaccaa                                                   20


<210> 14302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14302
agagatttgt gcaataaacc                                                   20


<210> 14303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14303
taggagaaac taggtcatta                                                   20


<210> 14304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14304
gttaggagaa actaggtcat                                                   20


<210> 14305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14305
gctttaagtt aggagaaact                                                   20


<210> 14306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14306
tgctttaagt taggagaaac                                                   20


<210> 14307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14307
aatattctgc tttaagttag                                                   20


<210> 14308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14308
gaaatattct gctttaagtt                                                   20


<210> 14309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14309
tgaaatattc tgctttaagt                                                   20


<210> 14310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14310
tttctgaaat attctgcttt                                                   20


<210> 14311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14311
tggtagctgg agggagatgt                                                   20


<210> 14312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14312
tctaagatgg tagctggagg                                                   20


<210> 14313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14313
gatctaagat ggtagctgga                                                   20


<210> 14314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14314
agatctaaga tggtagctgg                                                   20


<210> 14315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14315
gagatctaag atggtagctg                                                   20


<210> 14316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14316
aagagatcta agatggtagc                                                   20


<210> 14317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14317
tgggaagaga tctaagatgg                                                   20


<210> 14318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14318
aggtgggaag agatctaaga                                                   20


<210> 14319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14319
ttgaaggtgg gaagagatct                                                   20


<210> 14320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14320
ttttgctttg aaggtgggaa                                                   20


<210> 14321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14321
aattttgctt tgaaggtggg                                                   20


<210> 14322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14322
agaaattttg ctttgaaggt                                                   20


<210> 14323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14323
aagaaatttt gctttgaagg                                                   20


<210> 14324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14324
ttcaagaaat tttgctttga                                                   20


<210> 14325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14325
tttcaagaaa ttttgctttg                                                   20


<210> 14326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14326
tgattgtaca caactctttc                                                   20


<210> 14327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14327
gtgggctgag gagtgaatga                                                   20


<210> 14328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14328
tgtgggctga ggagtgaatg                                                   20


<210> 14329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14329
atgtgggctg aggagtgaat                                                   20


<210> 14330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14330
ctctgttgat gtgggctgag                                                   20


<210> 14331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14331
agctctgttg atgtgggctg                                                   20


<210> 14332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14332
aagctctgtt gatgtgggct                                                   20


<210> 14333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14333
ggcaaaagct ctgttgatgt                                                   20


<210> 14334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14334
aggcaaaagc tctgttgatg                                                   20


<210> 14335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14335
ctctgtcagg atagaggcaa                                                   20


<210> 14336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14336
aacaatctct gtcaggatag                                                   20


<210> 14337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14337
gaacaatctc tgtcaggata                                                   20


<210> 14338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14338
gagaacaatc tctgtcagga                                                   20


<210> 14339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14339
tagtgagaac aatctctgtc                                                   20


<210> 14340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14340
ttagtgagaa caatctctgt                                                   20


<210> 14341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14341
aagtcattca tgatcttagt                                                   20


<210> 14342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14342
tgggaagtca ttcatgatct                                                   20


<210> 14343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14343
cttggatcta atattatggg                                                   20


<210> 14344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14344
gtccttggat ctaatattat                                                   20


<210> 14345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14345
cgtccttgga tctaatatta                                                   20


<210> 14346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14346
caatatcaga caagcgtcct                                                   20


<210> 14347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14347
ggtactaggc aatatcagac                                                   20


<210> 14348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14348
agaagggtac taggcaatat                                                   20


<210> 14349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14349
tttcaaggta gaagggtact                                                   20


<210> 14350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14350
atttcaaggt agaagggtac                                                   20


<210> 14351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14351
agcaacattt caaggtagaa                                                   20


<210> 14352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14352
aagcaacatt tcaaggtaga                                                   20


<210> 14353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14353
aaagcaacat ttcaaggtag                                                   20


<210> 14354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14354
aagaaagcaa catttcaagg                                                   20


<210> 14355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14355
accaagaaag caacatttca                                                   20


<210> 14356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14356
gaccaagaaa gcaacatttc                                                   20


<210> 14357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14357
aggcatggtg gagaccaaga                                                   20


<210> 14358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14358
tgtaaggcat ggtggagacc                                                   20


<210> 14359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14359
cagaaatgta aggcatggtg                                                   20


<210> 14360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14360
agcagaaatg taaggcatgg                                                   20


<210> 14361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14361
agaagcagaa atgtaaggca                                                   20


<210> 14362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14362
agaaaagaag cagaaatgta                                                   20


<210> 14363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14363
aagaaaagaa gcagaaatgt                                                   20


<210> 14364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14364
acaaatggca agaaaagaag                                                   20


<210> 14365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14365
atcacaaatg gcaagaaaag                                                   20


<210> 14366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14366
agcatcacaa atggcaagaa                                                   20


<210> 14367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14367
aaaagagcat cacaaatggc                                                   20


<210> 14368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14368
ctataaaaga gcatcacaaa                                                   20


<210> 14369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14369
gggtaaagga gactataaaa                                                   20


<210> 14370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14370
ttgggtaaag gagactataa                                                   20


<210> 14371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14371
tgtctaaaag ttgggtaaag                                                   20


<210> 14372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14372
gatgtctaaa agttgggtaa                                                   20


<210> 14373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14373
tgatgtctaa aagttgggta                                                   20


<210> 14374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14374
aactctgatg tctaaaagtt                                                   20


<210> 14375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14375
gaactctgat gtctaaaagt                                                   20


<210> 14376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14376
cgaagaactc tgatgtctaa                                                   20


<210> 14377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14377
atgctcaaga ctgagcctcg                                                   20


<210> 14378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14378
agcaaaggat gctcaagact                                                   20


<210> 14379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14379
gtgaagagca aaggatgctc                                                   20


<210> 14380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14380
aaaaatgggg tgaagagcaa                                                   20


<210> 14381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14381
aaaaaatggg gtgaagagca                                                   20


<210> 14382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14382
gggagaaaaa atggggtgaa                                                   20


<210> 14383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14383
aagggagaaa aaatggggtg                                                   20


<210> 14384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14384
ttgtcaaggg agaaaaaatg                                                   20


<210> 14385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14385
attgtcaagg gagaaaaaat                                                   20


<210> 14386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14386
aattgtcaag ggagaaaaaa                                                   20


<210> 14387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14387
ggctggataa attgtcaagg                                                   20


<210> 14388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14388
ctggctggat aaattgtcaa                                                   20


<210> 14389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14389
cctggctgga taaattgtca                                                   20


<210> 14390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14390
tcctggctgg ataaattgtc                                                   20


<210> 14391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14391
catatatgtt aattcctggc                                                   20


<210> 14392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14392
tgcacatata tgttaattcc                                                   20


<210> 14393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14393
agaggcaaac agttggccaa                                                   20


<210> 14394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14394
cagtgacaga ggcaaacagt                                                   20


<210> 14395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14395
agtccagtga cagaggcaaa                                                   20


<210> 14396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14396
agtttacagt ccagtgacag                                                   20


<210> 14397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14397
cagtttacag tccagtgaca                                                   20


<210> 14398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14398
tacagtttac agtccagtga                                                   20


<210> 14399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14399
tactcttaca gtttacagtc                                                   20


<210> 14400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14400
gttcctactc ttacagttta                                                   20


<210> 14401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14401
agacaaagtt cctactctta                                                   20


<210> 14402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14402
agcagtgagc aagacagaca                                                   20


<210> 14403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14403
ggttagagca gtgagcaaga                                                   20


<210> 14404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14404
ccagggttag agcagtgagc                                                   20


<210> 14405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14405
gacaccaggg ttagagcagt                                                   20


<210> 14406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14406
tgcagacacc agggttagag                                                   20


<210> 14407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14407
ctatgcagac accagggtta                                                   20


<210> 14408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14408
cactatgcag acaccagggt                                                   20


<210> 14409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14409
caggcactat gcagacacca                                                   20


<210> 14410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14410
ccaggcacta tgcagacacc                                                   20


<210> 14411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14411
gccaggcact atgcagacac                                                   20


<210> 14412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14412
tgttgcagcc aggcactatg                                                   20


<210> 14413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14413
gcagagcatc tgttgcagcc                                                   20


<210> 14414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14414
tgcagagcat ctgttgcagc                                                   20


<210> 14415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14415
aatttgcaga gcatctgttg                                                   20


<210> 14416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14416
cattcattta caaatttgca                                                   20


<210> 14417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14417
tccattcatt tacaaatttg                                                   20


<210> 14418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14418
tttgagctat ggttaactca                                                   20


<210> 14419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14419
catttgagct atggttaact                                                   20


<210> 14420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14420
ttaaattttc atttgagcta                                                   20


<210> 14421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14421
gtgactttaa attttcattt                                                   20


<210> 14422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14422
attgaattta gtcaaataaa                                                   20


<210> 14423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14423
aattgaattt agtcaaataa                                                   20


<210> 14424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14424
gaattgaatt tagtcaaata                                                   20


<210> 14425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14425
ccttggtaca gaattgaatt                                                   20


<210> 14426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14426
ttcagtatgt acccttggta                                                   20


<210> 14427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14427
atacattcag tatgtaccct                                                   20


<210> 14428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14428
gcttgcacat cccatacatt                                                   20


<210> 14429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14429
cctcatagcc actcatgcag                                                   20


<210> 14430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14430
ccctcatagc cactcatgca                                                   20


<210> 14431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14431
ctccctcata gccactcatg                                                   20


<210> 14432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14432
gttcttctct tcctccctca                                                   20


<210> 14433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14433
ctccctggaa gggatcagac                                                   20


<210> 14434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14434
gctccctgga agggatcaga                                                   20


<210> 14435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14435
gtgggctccc tggaagggat                                                   20


<210> 14436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14436
ctcccgtggg ctccctggaa                                                   20


<210> 14437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14437
gctcccgtgg gctccctgga                                                   20


<210> 14438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14438
agctcccgtg ggctccctgg                                                   20


<210> 14439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14439
tgcagctccc gtgggctccc                                                   20


<210> 14440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14440
gcttgctgtg cagctcccgt                                                   20


<210> 14441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14441
tgcttgctgt gcagctcccg                                                   20


<210> 14442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14442
ttccccctct gcttgctgtg                                                   20


<210> 14443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14443
ggcaaggatc agcctcatca                                                   20


<210> 14444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14444
atgaagcaga aggcaaggat                                                   20


<210> 14445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14445
ccaccatgaa gcagaaggca                                                   20


<210> 14446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14446
cccaccatga agcagaaggc                                                   20


<210> 14447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14447
catccccacc atgaagcaga                                                   20


<210> 14448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14448
ccatccccac catgaagcag                                                   20


<210> 14449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14449
aacccatccc caccatgaag                                                   20


<210> 14450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14450
agcaacccat ccccaccatg                                                   20


<210> 14451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14451
tttgctctaa cccaacagga                                                   20


<210> 14452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14452
attctttgct ctaacccaac                                                   20


<210> 14453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14453
gattctttgc tctaacccaa                                                   20


<210> 14454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14454
gccatgagca aaggccactt                                                   20


<210> 14455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14455
agcagttctg ccatgagcaa                                                   20


<210> 14456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14456
cagcagttct gccatgagca                                                   20


<210> 14457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14457
tgagccagca gttctgccat                                                   20


<210> 14458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14458
ccaggaaaga tgtgagccag                                                   20


<210> 14459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14459
gccccaggaa agatgtgagc                                                   20


<210> 14460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14460
tcctgcccca ggaaagatgt                                                   20


<210> 14461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14461
atccccctcc tgccccagga                                                   20


<210> 14462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14462
agcaatcccc ctcctgcccc                                                   20


<210> 14463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14463
cagcaatccc cctcctgccc                                                   20


<210> 14464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14464
aatggaaggg attagtggct                                                   20


<210> 14465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14465
gatgaaatgg aagggattag                                                   20


<210> 14466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14466
agtgatgaaa tggaagggat                                                   20


<210> 14467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14467
ttttcagtga tgaaatggaa                                                   20


<210> 14468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14468
attttcagtg atgaaatgga                                                   20


<210> 14469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14469
cattttcagt gatgaaatgg                                                   20


<210> 14470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14470
caccattttc agtgatgaaa                                                   20


<210> 14471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14471
ctgtattttt tcaccatttt                                                   20


<210> 14472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14472
gaagtcatgt gaccatgaat                                                   20


<210> 14473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14473
agaagtcatg tgaccatgaa                                                   20


<210> 14474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14474
tgcctgctct gtttaattag                                                   20


<210> 14475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14475
cgttgcctgc tctgtttaat                                                   20


<210> 14476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14476
tccagggcaa acttcacacc                                                   20


<210> 14477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14477
ccctaaagtc agaatatcca                                                   20


<210> 14478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14478
tccctaaagt cagaatatcc                                                   20


<210> 14479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14479
ttccctaaag tcagaatatc                                                   20


<210> 14480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14480
gctactccat tccctaaagt                                                   20


<210> 14481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14481
gcaagctact ccattcccta                                                   20


<210> 14482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14482
ctaatccaag agcagctagc                                                   20


<210> 14483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14483
tgggctaatc caagagcagc                                                   20


<210> 14484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14484
accgtgggct aatccaagag                                                   20


<210> 14485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14485
ctgaccgtgg gctaatccaa                                                   20


<210> 14486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14486
ccctgaccgt gggctaatcc                                                   20


<210> 14487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14487
aaggtatgat ccctgaccgt                                                   20


<210> 14488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14488
aaaggtatga tccctgaccg                                                   20


<210> 14489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14489
gagagcacca agggttgcaa                                                   20


<210> 14490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14490
tgagagcacc aagggttgca                                                   20


<210> 14491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14491
atcgtctctg agagcaccaa                                                   20


<210> 14492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14492
catcgtctct gagagcacca                                                   20


<210> 14493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14493
tcatcgtctc tgagagcacc                                                   20


<210> 14494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14494
acccacttca tcgtctctga                                                   20


<210> 14495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14495
tcacccactt catcgtctct                                                   20


<210> 14496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14496
tagaaatata ataggctcta                                                   20


<210> 14497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14497
tatagaaata taataggctc                                                   20


<210> 14498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14498
ccactttata gaaatataat                                                   20


<210> 14499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14499
tccactttat agaaatataa                                                   20


<210> 14500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14500
ctctcacata ctccacttta                                                   20


<210> 14501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14501
gctacagaaa tcaataaaag                                                   20


<210> 14502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14502
cctgctacag aaatcaataa                                                   20


<210> 14503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14503
ttctttaaca ttccctgcta                                                   20


<210> 14504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14504
gttaaggatt ccacaagact                                                   20


<210> 14505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14505
agttaaggat tccacaagac                                                   20


<210> 14506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14506
ggaaaagtta aggattccac                                                   20


<210> 14507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14507
ttcttccata ggaaaagtta                                                   20


<210> 14508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14508
tttcttccat aggaaaagtt                                                   20


<210> 14509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14509
tcttgtttct tccataggaa                                                   20


<210> 14510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14510
ctaaatcttg tttcttccat                                                   20


<210> 14511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14511
tctaaatctt gtttcttcca                                                   20


<210> 14512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14512
tctcacctct gatgatgctc                                                   20


<210> 14513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14513
ctctcacctc tgatgatgct                                                   20


<210> 14514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14514
gcttacctgg gaccacatag                                                   20


<210> 14515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14515
gagcttacct gggaccacat                                                   20


<210> 14516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14516
agagcttacc tgggaccaca                                                   20


<210> 14517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14517
tttcatgaca gagcttacct                                                   20


<210> 14518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14518
atttcatgac agagcttacc                                                   20


<210> 14519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14519
atgggtgcca tttcatgaca                                                   20


<210> 14520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14520
gcatgggtgc catttcatga                                                   20


<210> 14521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14521
tttctgcccc atcagtgcat                                                   20


<210> 14522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14522
atttctgccc catcagtgca                                                   20


<210> 14523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14523
acacaggatt tctgccccat                                                   20


<210> 14524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14524
taccagcaaa gcactgacac                                                   20


<210> 14525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14525
ataccagcaa agcactgaca                                                   20


<210> 14526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14526
tcaagctggt cataccagca                                                   20


<210> 14527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14527
aaaggtcaag ctggtcatac                                                   20


<210> 14528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14528
aggagcccca aaggtcaagc                                                   20


<210> 14529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14529
ccttaggagc cccaaaggtc                                                   20


<210> 14530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14530
tctcccctta ggagccccaa                                                   20


<210> 14531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14531
ttctcccctt aggagcccca                                                   20


<210> 14532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14532
tgtccacctt ctccccttag                                                   20


<210> 14533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14533
aatgtccacc ttctcccctt                                                   20


<210> 14534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14534
gaatgtccac cttctcccct                                                   20


<210> 14535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14535
tttggccaga ttattggccc                                                   20


<210> 14536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14536
cttgcttttg gccagattat                                                   20


<210> 14537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14537
aggcccagct tgcttttggc                                                   20


<210> 14538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14538
tcccaggccc agcttgcttt                                                   20


<210> 14539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14539
aagacccttc ttcccaggcc                                                   20


<210> 14540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14540
caactaagac ccttcttccc                                                   20


<210> 14541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14541
ccaactaaga cccttcttcc                                                   20


<210> 14542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14542
ggaaattccc actcccaact                                                   20


<210> 14543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14543
agaaagaaat ccaaggcaaa                                                   20


<210> 14544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14544
aagaaagaaa tccaaggcaa                                                   20


<210> 14545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14545
agaaccaaga aagaaatcca                                                   20


<210> 14546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14546
tagaaccaag aaagaaatcc                                                   20


<210> 14547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14547
ttcaaagtct agaaccaaga                                                   20


<210> 14548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14548
cctcttcaaa gtctagaacc                                                   20


<210> 14549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14549
catcttccct cttcaaagtc                                                   20


<210> 14550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14550
cggatcatct tccctcttca                                                   20


<210> 14551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 14551
acatgcccag tggcacaagc                                                   20


<210> 14552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14552
acccacatgc ccagtggcac                                                   20


<210> 14553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14553
tttgacaccc acatgcccag                                                   20


<210> 14554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14554
atctttgaca cccacatgcc                                                   20


<210> 14555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14555
ctgaccagca tccaaatggc                                                   20


<210> 14556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14556
cctgaccagc atccaaatgg                                                   20


<210> 14557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14557
gctcctgacc agcatccaaa                                                   20


<210> 14558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14558
ggaccatcct agctcctgac                                                   20


<210> 14559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14559
ccataggtct tggaccatcc                                                   20


<210> 14560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14560
actccaggac ccataggtct                                                   20


<210> 14561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14561
ggctgcactc caggacccat                                                   20


<210> 14562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14562
tggctgcact ccaggaccca                                                   20


<210> 14563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14563
cctgcagatg gctgcactcc                                                   20


<210> 14564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14564
acctgcagat ggctgcactc                                                   20


<210> 14565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14565
gtccaagcag cacctgcaga                                                   20


<210> 14566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14566
cagagtccaa gcagcacctg                                                   20


<210> 14567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14567
agcacaaagc agagtccaag                                                   20


<210> 14568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14568
atcagcacaa agcagagtcc                                                   20


<210> 14569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14569
agagaaatca gcacaaagca                                                   20


<210> 14570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14570
acagagaaat cagcacaaag                                                   20


<210> 14571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14571
ccaacagaga aatcagcaca                                                   20


<210> 14572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14572
agggatgcca acagagaaat                                                   20


<210> 14573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14573
aagtggcagg gatgccaaca                                                   20


<210> 14574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14574
tgaagtggca gggatgccaa                                                   20


<210> 14575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14575
aacaaaactt tgaagtggca                                                   20


<210> 14576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14576
aaacaaaact ttgaagtggc                                                   20


<210> 14577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14577
taaacaaaac tttgaagtgg                                                   20


<210> 14578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14578
atttaaacaa aactttgaag                                                   20


<210> 14579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14579
aacatttaaa caaaactttg                                                   20


<210> 14580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14580
tcgcatagct gaggcaaggc                                                   20


<210> 14581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14581
aatttcgcat agctgaggca                                                   20


<210> 14582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14582
taatttcgca tagctgaggc                                                   20


<210> 14583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14583
tccctaattt cgcatagctg                                                   20


<210> 14584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14584
ttccctaatt tcgcatagct                                                   20


<210> 14585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14585
ctttgttccc taatttcgca                                                   20


<210> 14586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14586
ttaatattct ggcccaagca                                                   20


<210> 14587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14587
cttaatattc tggcccaagc                                                   20


<210> 14588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14588
tccccttaat attctggccc                                                   20


<210> 14589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14589
tggctctccc cttaatattc                                                   20


<210> 14590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14590
ctagccttag tggaggaacg                                                   20


<210> 14591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14591
ccttttgcta gccttagtgg                                                   20


<210> 14592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14592
accttttgct agccttagtg                                                   20


<210> 14593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14593
caaccttttg ctagccttag                                                   20


<210> 14594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14594
tctcaacctt ttgctagcct                                                   20


<210> 14595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14595
attcactctc aaccttttgc                                                   20


<210> 14596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14596
tgaatggaag aagagtggat                                                   20


<210> 14597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14597
tcctttgaat ggaagaagag                                                   20


<210> 14598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14598
ccatcctttg aatggaagaa                                                   20


<210> 14599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14599
ctccatcctt tgaatggaag                                                   20


<210> 14600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14600
attctccatc ctttgaatgg                                                   20


<210> 14601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14601
gagattctcc atcctttgaa                                                   20


<210> 14602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14602
tcataaccaa ttctgttcct                                                   20


<210> 14603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14603
gacctccaca tgtggagggg                                                   20


<210> 14604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14604
ggagacctcc acatgtggag                                                   20


<210> 14605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14605
gggagacctc cacatgtgga                                                   20


<210> 14606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14606
ggggagacct ccacatgtgg                                                   20


<210> 14607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14607
gggggagacc tccacatgtg                                                   20


<210> 14608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14608
cagggggaga cctccacatg                                                   20


<210> 14609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14609
ctccgaggat ggcacagggg                                                   20


<210> 14610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14610
tcctccgagg atggcacagg                                                   20


<210> 14611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14611
atcctccgag gatggcacag                                                   20


<210> 14612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14612
gatcctccga ggatggcaca                                                   20


<210> 14613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14613
agatcctccg aggatggcac                                                   20


<210> 14614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14614
aagatcctcc gaggatggca                                                   20


<210> 14615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14615
caactaagat cctccgagga                                                   20


<210> 14616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14616
gctgcaacta agatcctccg                                                   20


<210> 14617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14617
agctgcaact aagatcctcc                                                   20


<210> 14618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14618
ctcctaatta agctgcaact                                                   20


<210> 14619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14619
aatcaccatt tctcctaatt                                                   20


<210> 14620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14620
ggagttgatg gtcaggcagg                                                   20


<210> 14621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14621
gacggagttg atggtcaggc                                                   20


<210> 14622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14622
agacggagtt gatggtcagg                                                   20


<210> 14623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14623
gggagacgga gttgatggtc                                                   20


<210> 14624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14624
tgggagacgg agttgatggt                                                   20


<210> 14625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14625
ggagtgggag acggagttga                                                   20


<210> 14626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14626
gtaaatagga gtgggagacg                                                   20


<210> 14627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 14627
cagtaaatag gagtgggaga                                                   20


<210> 14628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14628
caggcagtaa ataggagtgg                                                   20


<210> 14629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14629
tccaggcagt aaataggagt                                                   20


<210> 14630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14630
ttccaggcag taaataggag                                                   20


<210> 14631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14631
aaattccagg cagtaaatag                                                   20


<210> 14632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14632
tgaaattcca ggcagtaaat                                                   20


<210> 14633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14633
ttgaaattcc aggcagtaaa                                                   20


<210> 14634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14634
cctaatgttg aaattccagg                                                   20


<210> 14635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14635
gaccctaatg ttgaaattcc                                                   20


<210> 14636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14636
tgaccctaat gttgaaattc                                                   20


<210> 14637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14637
gagagggcat ctacctacaa                                                   20


<210> 14638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14638
ggagagggca tctacctaca                                                   20


<210> 14639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14639
tcaaaaaggg accctggaga                                                   20


<210> 14640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14640
ttcaaaaagg gaccctggag                                                   20


<210> 14641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14641
tttcaaaaag ggaccctgga                                                   20


<210> 14642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14642
tatttcaaaa agggaccctg                                                   20


<210> 14643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14643
catatttcaa aaagggaccc                                                   20


<210> 14644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14644
gataaatcat atttcaaaaa                                                   20


<210> 14645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14645
agataaatca tatttcaaaa                                                   20


<210> 14646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14646
aagataaatc atatttcaaa                                                   20


<210> 14647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14647
gaagacaaca ttcttaggac                                                   20


<210> 14648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14648
tcaaggaaga caacattctt                                                   20


<210> 14649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14649
ctcaaggaag acaacattct                                                   20


<210> 14650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14650
aaagcttcct cccctcaagg                                                   20


<210> 14651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14651
aagaaagctt cctcccctca                                                   20


<210> 14652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14652
aaagaaagct tcctcccctc                                                   20


<210> 14653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14653
accccatagg ctgccaaaga                                                   20


<210> 14654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14654
cccaacccca taggctgcca                                                   20


<210> 14655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14655
ctgtcatcac ccaaccccat                                                   20


<210> 14656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14656
cctgtcatca cccaacccca                                                   20


<210> 14657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14657
tcaatctctc tttgacatcc                                                   20


<210> 14658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14658
ggcaaaaaca tgaaagtttt                                                   20


<210> 14659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14659
aacccttggc aaaaacatga                                                   20


<210> 14660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14660
tgtgtgctag ggacaaccct                                                   20


<210> 14661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14661
tgccaaggag gtgtgtgcta                                                   20


<210> 14662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14662
atgccaagga ggtgtgtgct                                                   20


<210> 14663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14663
gatgccaagg aggtgtgtgc                                                   20


<210> 14664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14664
atttgagcca gatgccaagg                                                   20


<210> 14665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14665
catttgagcc agatgccaag                                                   20


<210> 14666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14666
cacatttgag ccagatgcca                                                   20


<210> 14667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14667
ccacatttga gccagatgcc                                                   20


<210> 14668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14668
gattgaatcc acatttgagc                                                   20


<210> 14669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14669
gtaagattga atccacattt                                                   20


<210> 14670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14670
cctttacttg tggctggagt                                                   20


<210> 14671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14671
ctggccttta cttgtggctg                                                   20


<210> 14672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14672
cactggcctt tacttgtggc                                                   20


<210> 14673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14673
tccacactgg cctttacttg                                                   20


<210> 14674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14674
gcaagcagct gagtccacac                                                   20


<210> 14675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14675
ttactgagaa gcaagcagct                                                   20


<210> 14676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14676
aagacttact gagaagcaag                                                   20


<210> 14677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14677
cctaagactt actgagaagc                                                   20


<210> 14678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14678
ggaccctaag acttactgag                                                   20


<210> 14679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14679
ggaggaccct aagacttact                                                   20


<210> 14680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14680
ggtaatgaga ggaggaccct                                                   20


<210> 14681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14681
aagtcatggg taatgagagg                                                   20


<210> 14682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14682
caagtcatgg gtaatgagag                                                   20


<210> 14683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14683
ttcaagtcat gggtaatgag                                                   20


<210> 14684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14684
attcaagtca tgggtaatga                                                   20


<210> 14685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14685
acattcaagt catgggtaat                                                   20


<210> 14686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14686
cccaaccaca ttcaagtcat                                                   20


<210> 14687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14687
tcccaaccac attcaagtca                                                   20


<210> 14688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14688
gctgagtccc aaccacattc                                                   20


<210> 14689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14689
ttaaaattag gtgaaaggct                                                   20


<210> 14690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14690
caaaattaaa attaggtgaa                                                   20


<210> 14691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14691
tcaaaattaa aattaggtga                                                   20


<210> 14692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14692
gcaggctcaa aattaaaatt                                                   20


<210> 14693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14693
agcaggctca aaattaaaat                                                   20


<210> 14694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14694
caagttcagt ggagaggagc                                                   20


<210> 14695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14695
acaagttcag tggagaggag                                                   20


<210> 14696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14696
tcaacaagtt cagtggagag                                                   20


<210> 14697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14697
catcaacaag ttcagtggag                                                   20


<210> 14698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14698
ccatcaacaa gttcagtgga                                                   20


<210> 14699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14699
ctccatcaac aagttcagtg                                                   20


<210> 14700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14700
ccctccatca acaagttcag                                                   20


<210> 14701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14701
tatccctcca tcaacaagtt                                                   20


<210> 14702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14702
ttgagtatcc ctccatcaac                                                   20


<210> 14703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14703
caaaagtcct taggctcatt                                                   20


<210> 14704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14704
gaacctgagc aaaagtcctt                                                   20


<210> 14705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14705
tgaacctgag caaaagtcct                                                   20


<210> 14706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14706
atttgagtga acctgagcaa                                                   20


<210> 14707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14707
aactggattt gagtgaacct                                                   20


<210> 14708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14708
caatcaagat aactggattt                                                   20


<210> 14709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14709
acccatacaa tcaagataac                                                   20


<210> 14710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14710
cctaaatcac ccatacaatc                                                   20


<210> 14711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14711
ttcagacctc tgtaggggca                                                   20


<210> 14712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14712
ggaggttcag acctctgtag                                                   20


<210> 14713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14713
aggaggttca gacctctgta                                                   20


<210> 14714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14714
taggaggttc agacctctgt                                                   20


<210> 14715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14715
ataggaggtt cagacctctg                                                   20


<210> 14716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14716
gtggggagtg ataggaggtt                                                   20


<210> 14717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14717
ggggagtggg gagtgatagg                                                   20


<210> 14718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14718
tggggagtgg ggagtgatag                                                   20


<210> 14719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14719
aatggggagt ggggagtgat                                                   20


<210> 14720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14720
caatggggag tggggagtga                                                   20


<210> 14721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14721
gtattacaat ggggagtggg                                                   20


<210> 14722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14722
aagtattaca atggggagtg                                                   20


<210> 14723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14723
gaagtattac aatggggagt                                                   20


<210> 14724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14724
agaagtatta caatggggag                                                   20


<210> 14725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14725
ataagaagta ttacaatggg                                                   20


<210> 14726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14726
tgataagaag tattacaatg                                                   20


<210> 14727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14727
ctgataagaa gtattacaat                                                   20


<210> 14728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14728
tctgataaga agtattacaa                                                   20


<210> 14729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14729
ctagtctaga ttctgataag                                                   20


<210> 14730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14730
ttactagtct agattctgat                                                   20


<210> 14731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14731
tcatgaattt attactagtc                                                   20


<210> 14732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14732
agtggtcatg aatttattac                                                   20


<210> 14733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14733
gacactgtat tttgaaatag                                                   20


<210> 14734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14734
tttgacactg tattttgaaa                                                   20


<210> 14735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14735
aaaacattta caagagaaaa                                                   20


<210> 14736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14736
aaagtgaaaa acatttacaa                                                   20


<210> 14737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14737
acaaagtgaa aaacatttac                                                   20


<210> 14738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14738
cttcaaactt tgtcagaaca                                                   20


<210> 14739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14739
taatttactt caaactttgt                                                   20


<210> 14740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14740
atttttttaa atcaaggtat                                                   20


<210> 14741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14741
gattttttta aatcaaggta                                                   20


<210> 14742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14742
tattagattt ttttaaatca                                                   20


<210> 14743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14743
ctattagatt tttttaaatc                                                   20


<210> 14744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14744
cattctgtta gccaagctat                                                   20


<210> 14745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14745
agacatgcat tctgttagcc                                                   20


<210> 14746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14746
tatggagaca tgcattctgt                                                   20


<210> 14747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14747
ctttccctaa atgaattatg                                                   20


<210> 14748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14748
gcctttccct aaatgaatta                                                   20


<210> 14749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14749
aggacattta acaaaggaac                                                   20


<210> 14750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14750
gtccaaagga catttaacaa                                                   20


<210> 14751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14751
agtccaaagg acatttaaca                                                   20


<210> 14752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14752
cacacaaggg aaaagtccaa                                                   20


<210> 14753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14753
ccacacaagg gaaaagtcca                                                   20


<210> 14754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14754
cccttcccca cacaagggaa                                                   20


<210> 14755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14755
attagccctt ccccacacaa                                                   20


<210> 14756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14756
cattagccct tccccacaca                                                   20


<210> 14757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14757
tcattagccc ttccccacac                                                   20


<210> 14758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14758
tgctgatgac acaatttcat                                                   20


<210> 14759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14759
gcattagtga agaaaatcac                                                   20


<210> 14760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14760
agcattagtg aagaaaatca                                                   20


<210> 14761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14761
gctaagatgc agcattagtg                                                   20


<210> 14762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14762
ctgtggctaa gatgcagcat                                                   20


<210> 14763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14763
aactttctgt ggctaagatg                                                   20


<210> 14764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14764
tacataaact ttctgtggct                                                   20


<210> 14765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14765
ccttctacat aaactttctg                                                   20


<210> 14766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14766
tccactccag tgaatggaat                                                   20


<210> 14767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14767
gagccatcca ctccagtgaa                                                   20


<210> 14768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14768
aatttctgag ccatccactc                                                   20


<210> 14769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14769
atcgtcttca aagaatttct                                                   20


<210> 14770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14770
attattgttg atcgtcttca                                                   20


<210> 14771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14771
gggtgaagat gttgatgtgt                                                   20


<210> 14772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14772
gatgaacagg tttgggggtg                                                   20


<210> 14773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14773
gaatggatga acaggtttgg                                                   20


<210> 14774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14774
ggaatggatg aacaggtttg                                                   20


<210> 14775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14775
gggaatggat gaacaggttt                                                   20


<210> 14776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14776
tgggaatgga tgaacaggtt                                                   20


<210> 14777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14777
ttttttggga atggatgaac                                                   20


<210> 14778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14778
cttttttggg aatggatgaa                                                   20


<210> 14779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14779
agatagcact tttttgggaa                                                   20


<210> 14780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14780
ccctaagata gcactttttt                                                   20


<210> 14781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14781
gccctaagat agcacttttt                                                   20


<210> 14782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14782
gcctctgaga ggccctaaga                                                   20


<210> 14783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14783
tcaagcctct gagaggccct                                                   20


<210> 14784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14784
gaaaacatca agcctctgag                                                   20


<210> 14785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14785
agaaaacatc aagcctctga                                                   20


<210> 14786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14786
atagaaaaca tcaagcctct                                                   20


<210> 14787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14787
gccagaagat agaaaacatc                                                   20


<210> 14788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14788
ctcagtcttc tgccagaaga                                                   20


<210> 14789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14789
tcttctcagt cttctgccag                                                   20


<210> 14790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14790
agttcttctc agtcttctgc                                                   20


<210> 14791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14791
gatatcacct aagttcttct                                                   20


<210> 14792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14792
taccacacat gatatcacct                                                   20


<210> 14793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14793
cataaagatc tcaagagaca                                                   20


<210> 14794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14794
ttttttcata aagatctcaa                                                   20


<210> 14795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14795
ccttttttca taaagatctc                                                   20


<210> 14796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14796
gtttcactcc ttttttcata                                                   20


<210> 14797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14797
caaaaattag ggccagactc                                                   20


<210> 14798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14798
gattgggcaa aaattagggc                                                   20


<210> 14799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14799
taaagattgg gcaaaaatta                                                   20


<210> 14800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14800
ttaaagattg ggcaaaaatt                                                   20


<210> 14801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14801
tttaaagatt gggcaaaaat                                                   20


<210> 14802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14802
cccactcgag tttaaagatt                                                   20


<210> 14803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14803
tcccactcga gtttaaagat                                                   20


<210> 14804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14804
agttatccca ctcgagttta                                                   20


<210> 14805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14805
aaccaaaagt tatcccactc                                                   20


<210> 14806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14806
agtggcccag taggaaccaa                                                   20


<210> 14807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14807
tagtggtcaa gtggcccagt                                                   20


<210> 14808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14808
gtagtggtca agtggcccag                                                   20


<210> 14809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14809
atggtagtgg tcaagtggcc                                                   20


<210> 14810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14810
cagtcatggt agtggtcaag                                                   20


<210> 14811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14811
atgcagtcat ggtagtggtc                                                   20


<210> 14812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14812
ccaagatgca gtcatggtag                                                   20


<210> 14813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14813
gatccaagat gcagtcatgg                                                   20


<210> 14814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14814
caggatccaa gatgcagtca                                                   20


<210> 14815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14815
ccctgtcagg atccaagatg                                                   20


<210> 14816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14816
caactcccct gtcaggatcc                                                   20


<210> 14817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14817
aacaacccaa ctcccctgtc                                                   20


<210> 14818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14818
caacaaccca actcccctgt                                                   20


<210> 14819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14819
ccacgcctac aggtatagag                                                   20


<210> 14820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14820
cccacgccta caggtataga                                                   20


<210> 14821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14821
accccacgcc tacaggtata                                                   20


<210> 14822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14822
ctaccccacg cctacaggta                                                   20


<210> 14823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14823
atattctacc ccacgcctac                                                   20


<210> 14824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14824
tatattctac cccacgccta                                                   20


<210> 14825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14825
tctaggtcgc agtagatctc                                                   20


<210> 14826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14826
tatcatggtc taggtcgcag                                                   20


<210> 14827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14827
atgtatcatg gtctaggtcg                                                   20


<210> 14828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14828
gtggttatgt atcatggtct                                                   20


<210> 14829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14829
tgtggttatg tatcatggtc                                                   20


<210> 14830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14830
acttgtgtgg ttatgtatca                                                   20


<210> 14831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14831
acccagggat taaacttgtg                                                   20


<210> 14832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14832
gtaagggtag ttagaaccca                                                   20


<210> 14833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14833
agtaagggta gttagaaccc                                                   20


<210> 14834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14834
cagtaagggt agttagaacc                                                   20


<210> 14835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14835
taagtgacag taagggtagt                                                   20


<210> 14836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14836
aagctaagtg acagtaaggg                                                   20


<210> 14837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14837
gttaagctaa gtgacagtaa                                                   20


<210> 14838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14838
ggttaagcta agtgacagta                                                   20


<210> 14839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14839
aggttaagct aagtgacagt                                                   20


<210> 14840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14840
aggcaggtta agctaagtga                                                   20


<210> 14841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14841
gattggaggc aggttaagct                                                   20


<210> 14842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14842
tacaggattg gaggcaggtt                                                   20


<210> 14843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14843
tcaagtacag gattggaggc                                                   20


<210> 14844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14844
ttcaagtaca ggattggagg                                                   20


<210> 14845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14845
gagttcaagt acaggattgg                                                   20


<210> 14846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14846
agagttcaag tacaggattg                                                   20


<210> 14847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14847
ttagagttca agtacaggat                                                   20


<210> 14848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14848
cagttttaga gttcaagtac                                                   20


<210> 14849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14849
acagttttag agttcaagta                                                   20


<210> 14850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14850
ctccaacagt tttagagttc                                                   20


<210> 14851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14851
gagtttctcc aacagtttta                                                   20


<210> 14852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14852
ctgagtttct ccaacagttt                                                   20


<210> 14853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14853
gaagcactga gtttctccaa                                                   20


<210> 14854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14854
aatctgttgg gggaagcact                                                   20


<210> 14855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14855
tgaaatgaat ctgttggggg                                                   20


<210> 14856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14856
atttgaaatg aatctgttgg                                                   20


<210> 14857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14857
tatttgaaat gaatctgttg                                                   20


<210> 14858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14858
ctatttgaaa tgaatctgtt                                                   20


<210> 14859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14859
gctatttgaa atgaatctgt                                                   20


<210> 14860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14860
tggagtaaac atacctttta                                                   20


<210> 14861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14861
gaagcaactc tggtcttctg                                                   20


<210> 14862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14862
aagaagcaac tctggtcttc                                                   20


<210> 14863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14863
aagttcaaaa gaagcaactc                                                   20


<210> 14864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14864
aggaatgaga agttcaaaag                                                   20


<210> 14865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14865
ccaaggaatg agaagttcaa                                                   20


<210> 14866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14866
tcctaggccc aaggaatgag                                                   20


<210> 14867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14867
ggttcctagg cccaaggaat                                                   20


<210> 14868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14868
gatgagggtt cctaggccca                                                   20


<210> 14869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14869
tgatgagggt tcctaggccc                                                   20


<210> 14870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14870
tgagggtgat gagggttcct                                                   20


<210> 14871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14871
atgagggtga tgagggttcc                                                   20


<210> 14872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14872
cgttgggatg agggtgatga                                                   20


<210> 14873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14873
acgttgggat gagggtgatg                                                   20


<210> 14874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14874
gacgttggga tgagggtgat                                                   20


<210> 14875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14875
ctgggttgac gttgggatga                                                   20


<210> 14876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14876
tctgggttga cgttgggatg                                                   20


<210> 14877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14877
atctgggttg acgttgggat                                                   20


<210> 14878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14878
agaagatctg ggttgacgtt                                                   20


<210> 14879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14879
gagaagatct gggttgacgt                                                   20


<210> 14880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14880
gtttatggaa gagaagatct                                                   20


<210> 14881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14881
tgtttatgga agagaagatc                                                   20


<210> 14882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14882
gagtgctgtt tatggaagag                                                   20


<210> 14883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14883
agggagtgct gtttatggaa                                                   20


<210> 14884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14884
tgagggagtg ctgtttatgg                                                   20


<210> 14885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14885
gcctgaggga gtgctgttta                                                   20


<210> 14886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14886
tgtcaggcag gggcctgagg                                                   20


<210> 14887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14887
tgtgtcaggc aggggcctga                                                   20


<210> 14888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14888
ctgtgtcagg caggggcctg                                                   20


<210> 14889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14889
cctgtgtcag gcaggggcct                                                   20


<210> 14890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14890
tctatgcctg tgtcaggcag                                                   20


<210> 14891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14891
gtctatgcct gtgtcaggca                                                   20


<210> 14892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14892
agtctatgcc tgtgtcaggc                                                   20


<210> 14893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14893
cagtctatgc ctgtgtcagg                                                   20


<210> 14894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14894
tgacagtcta tgcctgtgtc                                                   20


<210> 14895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14895
atgacagtct atgcctgtgt                                                   20


<210> 14896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14896
tgtctgtgaa tccaacatga                                                   20


<210> 14897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14897
cccagaggtt tcctctagca                                                   20


<210> 14898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14898
tgagccccag aggtttcctc                                                   20


<210> 14899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14899
cggcccctgg tgagccccag                                                   20


<210> 14900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14900
acggcccctg gtgagcccca                                                   20


<210> 14901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14901
ccacggcccc tggtgagccc                                                   20


<210> 14902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14902
cccatcccac ggcccctggt                                                   20


<210> 14903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14903
gaagcccatc ccacggcccc                                                   20


<210> 14904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 14904
agccccagaa gcccatccca                                                   20


<210> 14905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14905
tgggctccaa gaagccccag                                                   20


<210> 14906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14906
agttgggctc caagaagccc                                                   20


<210> 14907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14907
tgaagaagtt gggctccaag                                                   20


<210> 14908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14908
ccatgaagaa gttgggctcc                                                   20


<210> 14909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14909
tacaatgcca tgaagaagtt                                                   20


<210> 14910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14910
ctacaatgcc atgaagaagt                                                   20


<210> 14911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14911
aatactacaa tgccatgaag                                                   20


<210> 14912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14912
agaaatacta caatgccatg                                                   20


<210> 14913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14913
tcttcatgac agaggagcag                                                   20


<210> 14914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14914
acatcttcat gacagaggag                                                   20


<210> 14915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14915
aggacatctt catgacagag                                                   20


<210> 14916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14916
ccaggacatc ttcatgacag                                                   20


<210> 14917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14917
gccaggacat cttcatgaca                                                   20


<210> 14918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14918
gggccaggac atcttcatga                                                   20


<210> 14919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14919
ctctctgcac ttagggggcc                                                   20


<210> 14920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14920
cctctctgca cttagggggc                                                   20


<210> 14921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14921
tggccctctc tgcacttagg                                                   20


<210> 14922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14922
gtggccctct ctgcacttag                                                   20


<210> 14923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14923
tgtggccctc tctgcactta                                                   20


<210> 14924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14924
gtgtggccct ctctgcactt                                                   20


<210> 14925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14925
agtgtggccc tctctgcact                                                   20


<210> 14926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14926
ctcttgcttt agtaacagtg                                                   20


<210> 14927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14927
ggttcctctt gctttagtaa                                                   20


<210> 14928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14928
gtagggggtt cctcttgctt                                                   20


<210> 14929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14929
ctgattttgg tatccgtagg                                                   20


<210> 14930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14930
tctgattttg gtatccgtag                                                   20


<210> 14931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14931
ttctgatttt ggtatccgta                                                   20


<210> 14932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14932
gttctgattt tggtatccgt                                                   20


<210> 14933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14933
tgttctgatt ttggtatccg                                                   20


<210> 14934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14934
tctcctgcct gttctgattt                                                   20


<210> 14935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14935
tatctgcaga ggaggggaga                                                   20


<210> 14936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14936
ctatctgcag aggaggggag                                                   20


<210> 14937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14937
tgtctatctg cagaggaggg                                                   20


<210> 14938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14938
tttgtctatc tgcagaggag                                                   20


<210> 14939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14939
gtttgtctat ctgcagagga                                                   20


<210> 14940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14940
ggtttgtcta tctgcagagg                                                   20


<210> 14941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14941
tggtttgtct atctgcagag                                                   20


<210> 14942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14942
cttggtttgt ctatctgcag                                                   20


<210> 14943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14943
gcttggtttg tctatctgca                                                   20


<210> 14944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14944
gggcttggtt tgtctatctg                                                   20


<210> 14945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14945
acactccttg atgctgggct                                                   20


<210> 14946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14946
gcaagacact ccttgatgct                                                   20


<210> 14947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14947
ggcaagacac tccttgatgc                                                   20


<210> 14948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14948
gttccgacac tggatgtggc                                                   20


<210> 14949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14949
caccgttccg acactggatg                                                   20


<210> 14950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14950
cagtcccacc gttccgacac                                                   20


<210> 14951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14951
agggagtcag caatggaact                                                   20


<210> 14952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14952
cccaggcagg gagtcagcaa                                                   20


<210> 14953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14953
tagagaccca ggcagggagt                                                   20


<210> 14954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14954
gctttagaga cccaggcagg                                                   20


<210> 14955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14955
ttgctttaga gacccaggca                                                   20


<210> 14956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14956
tttgctttag agacccaggc                                                   20


<210> 14957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14957
ctttgcttta gagacccagg                                                   20


<210> 14958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14958
tggctttgct ttagagaccc                                                   20


<210> 14959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14959
ctggctttgc tttagagacc                                                   20


<210> 14960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14960
cagaaactgg ctttgcttta                                                   20


<210> 14961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14961
aacagaaact ggctttgctt                                                   20


<210> 14962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14962
gatccctgga gaacagaaac                                                   20


<210> 14963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14963
atctctggat ccctggagaa                                                   20


<210> 14964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14964
ccagcatctc tggatccctg                                                   20


<210> 14965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14965
atccagcatc tctggatccc                                                   20


<210> 14966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14966
caccctttat ccagcatctc                                                   20


<210> 14967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14967
aaccctcccc accctttatc                                                   20


<210> 14968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14968
ccaacatgta ccttctcctt                                                   20


<210> 14969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14969
aacaggctag atccaaggct                                                   20


<210> 14970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14970
gaatgaacag gctagatcca                                                   20


<210> 14971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14971
ggaatgaaca ggctagatcc                                                   20


<210> 14972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14972
ttttactgga atgaacaggc                                                   20


<210> 14973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14973
agaattttac tggaatgaac                                                   20


<210> 14974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14974
aagaatttta ctggaatgaa                                                   20


<210> 14975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14975
agaagcccaa agaattttac                                                   20


<210> 14976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14976
actgtgactc tagaagccca                                                   20


<210> 14977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14977
gggagggact gtgactctag                                                   20


<210> 14978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 14978
cctgggaggg actgtgactc                                                   20


<210> 14979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14979
aaatctcttg ccccctggga                                                   20


<210> 14980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14980
gaaatctctt gccccctggg                                                   20


<210> 14981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14981
ggaaatctct tgccccctgg                                                   20


<210> 14982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14982
caggaaatct cttgccccct                                                   20


<210> 14983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 14983
tcaggaaatc tcttgccccc                                                   20


<210> 14984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14984
gtctttgctt caaggtcctc                                                   20


<210> 14985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14985
agtctttgct tcaaggtcct                                                   20


<210> 14986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14986
ctcccagagt ctttgcttca                                                   20


<210> 14987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14987
cctcccagag tctttgcttc                                                   20


<210> 14988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14988
gagggcttct gtccctccca                                                   20


<210> 14989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14989
ttgagggctt ctgtccctcc                                                   20


<210> 14990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 14990
cctctccaga aaagatttga                                                   20


<210> 14991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14991
tcctctccag aaaagatttg                                                   20


<210> 14992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 14992
ctcctctcca gaaaagattt                                                   20


<210> 14993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14993
tcatctcctc ctctccagaa                                                   20


<210> 14994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14994
tgtcctcatc tcctcctctc                                                   20


<210> 14995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 14995
ccaaggaccc aaggataagg                                                   20


<210> 14996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14996
agaccaagga cccaaggata                                                   20


<210> 14997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14997
gagaccaagg acccaaggat                                                   20


<210> 14998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 14998
cctctgagac caaggaccca                                                   20


<210> 14999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 14999
ccctctgaga ccaaggaccc                                                   20


<210> 15000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15000
cagaggtccc tctgagacca                                                   20


<210> 15001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15001
ccagaggtcc ctctgagacc                                                   20


<210> 15002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15002
agagaaccag aggtccctct                                                   20


<210> 15003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15003
cagggcctca agagaaccag                                                   20


<210> 15004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15004
gcagggcctc aagagaacca                                                   20


<210> 15005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15005
tggcagggcc tcaagagaac                                                   20


<210> 15006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15006
tgtgactggc agggcctcaa                                                   20


<210> 15007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15007
agtgtgactg gcagggcctc                                                   20


<210> 15008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15008
agagggcagt gtgactggca                                                   20


<210> 15009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15009
cagagggcag tgtgactggc                                                   20


<210> 15010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15010
gcagagggca gtgtgactgg                                                   20


<210> 15011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15011
acagcagagg gcagtgtgac                                                   20


<210> 15012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15012
ggcactgtaa cagcagaggg                                                   20


<210> 15013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15013
tctggcactg taacagcaga                                                   20


<210> 15014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15014
ttctggcact gtaacagcag                                                   20


<210> 15015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15015
tttctggcac tgtaacagca                                                   20


<210> 15016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15016
agtttctggc actgtaacag                                                   20


<210> 15017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15017
tgcagtttct ggcactgtaa                                                   20


<210> 15018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15018
atcttcgttg gtgcagtttc                                                   20


<210> 15019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15019
ggaaaacatc ttcgttggtg                                                   20


<210> 15020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15020
agggaggaaa acatcttcgt                                                   20


<210> 15021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15021
ctaataccca atcctaaggg                                                   20


<210> 15022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15022
actaataccc aatcctaagg                                                   20


<210> 15023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15023
aaactaatac ccaatcctaa                                                   20


<210> 15024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15024
aaaactaata cccaatccta                                                   20


<210> 15025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15025
aaaaactaat acccaatcct                                                   20


<210> 15026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15026
gaaaatccaa agggccccta                                                   20


<210> 15027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15027
ttgaatgaag aaaatccaaa                                                   20


<210> 15028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15028
tttgaatgaa gaaaatccaa                                                   20


<210> 15029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15029
gtttgaatga agaaaatcca                                                   20


<210> 15030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15030
taaaggtgag agtttgaatg                                                   20


<210> 15031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15031
tgtcaggaag ctaaaggtga                                                   20


<210> 15032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15032
tatgtcagga agctaaaggt                                                   20


<210> 15033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15033
aaattatgtc aggaagctaa                                                   20


<210> 15034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15034
caaattatgt caggaagcta                                                   20


<210> 15035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15035
ggctttcaaa ttatgtcagg                                                   20


<210> 15036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15036
ggtggctttc aaattatgtc                                                   20


<210> 15037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15037
aggtggcttt caaattatgt                                                   20


<210> 15038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15038
aaacatgtta ttaaaatagg                                                   20


<210> 15039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15039
cataaacatg ttattaaaat                                                   20


<210> 15040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15040
acataaacat gttattaaaa                                                   20


<210> 15041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15041
ccagtttccc agcatttgca                                                   20


<210> 15042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15042
cccagtttcc cagcatttgc                                                   20


<210> 15043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15043
gcccagtttc ccagcatttg                                                   20


<210> 15044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15044
cagatctcag cccagtttcc                                                   20


<210> 15045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15045
aaattccaca gatctcagcc                                                   20


<210> 15046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15046
ctttcaaatt ccacagatct                                                   20


<210> 15047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15047
agatctcctt tcaaattcca                                                   20


<210> 15048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15048
tttgtgtcca cagatcttct                                                   20


<210> 15049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15049
caggaagccc tttgtgtcca                                                   20


<210> 15050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15050
ataaagatgg tcctcccagg                                                   20


<210> 15051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15051
cccataaaga tggtcctccc                                                   20


<210> 15052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15052
ccccataaag atggtcctcc                                                   20


<210> 15053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15053
cttctctccc cccataaaga                                                   20


<210> 15054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15054
tttccttctc tccccccata                                                   20


<210> 15055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15055
tctcagcatg acctcacctg                                                   20


<210> 15056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15056
gttctcagca tgacctcacc                                                   20


<210> 15057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15057
gaatccttgg tcagagttct                                                   20


<210> 15058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15058
atctactgaa tccttggtca                                                   20


<210> 15059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15059
gcatctactg aatccttggt                                                   20


<210> 15060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15060
aactgcatct actgaatcct                                                   20


<210> 15061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15061
gtgaccaggc tggggtcact                                                   20


<210> 15062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15062
atgagctagt gaccaggctg                                                   20


<210> 15063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15063
gatgagctag tgaccaggct                                                   20


<210> 15064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15064
agatgagcta gtgaccaggc                                                   20


<210> 15065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15065
aaggagatga gctagtgacc                                                   20


<210> 15066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15066
gaaggagatg agctagtgac                                                   20


<210> 15067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15067
ggtaacggaa ggagatgagc                                                   20


<210> 15068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15068
attaggtaac ggaaggagat                                                   20


<210> 15069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15069
gagatattag gtaacggaag                                                   20


<210> 15070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15070
gggagatatt aggtaacgga                                                   20


<210> 15071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15071
agggagatat taggtaacgg                                                   20


<210> 15072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 15072
cagagggaga tattaggtaa                                                   20


<210> 15073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15073
agattacaga gggagatatt                                                   20


<210> 15074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15074
cagattacag agggagatat                                                   20


<210> 15075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15075
caagaaacag attacagagg                                                   20


<210> 15076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15076
gtcaagaaac agattacaga                                                   20


<210> 15077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15077
ggtcaagaaa cagattacag                                                   20


<210> 15078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15078
aggtcaagaa acagattaca                                                   20


<210> 15079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15079
tgaggtcaag aaacagatta                                                   20


<210> 15080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15080
agaaaactga ggtcaagaaa                                                   20


<210> 15081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15081
cagatgagaa aactgaggtc                                                   20


<210> 15082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15082
ttttacagat gagaaaactg                                                   20


<210> 15083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15083
attttacaga tgagaaaact                                                   20


<210> 15084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15084
atttctctca ttttacagat                                                   20


<210> 15085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15085
caatcatttc tctcatttta                                                   20


<210> 15086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15086
ggggaggttt gagattattg                                                   20


<210> 15087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15087
ttagtaccct ggggaggttt                                                   20


<210> 15088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15088
tgctatttag taccctgggg                                                   20


<210> 15089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15089
gtgctattta gtaccctggg                                                   20


<210> 15090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15090
cagtgctatt tagtaccctg                                                   20


<210> 15091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15091
acagtgctat ttagtaccct                                                   20


<210> 15092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15092
gacagtgcta tttagtaccc                                                   20


<210> 15093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15093
tgggacaaga cagtgctatt                                                   20


<210> 15094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15094
aggataggtc tgggacaaga                                                   20


<210> 15095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15095
ggacaggata ggtctgggac                                                   20


<210> 15096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15096
gaagaggaca ggataggtct                                                   20


<210> 15097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15097
agaagaggac aggataggtc                                                   20


<210> 15098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15098
gcataagaag aggacaggat                                                   20


<210> 15099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15099
agcataagaa gaggacagga                                                   20


<210> 15100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15100
tctgagcata agaagaggac                                                   20


<210> 15101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15101
ttctgagcat aagaagagga                                                   20


<210> 15102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15102
agggttctga gcataagaag                                                   20


<210> 15103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15103
cagggttctg agcataagaa                                                   20


<210> 15104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15104
cccagggttc tgagcataag                                                   20


<210> 15105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15105
ttgcccaggg ttctgagcat                                                   20


<210> 15106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15106
aaatccttgc ccagggttct                                                   20


<210> 15107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15107
ttacaggaaa tccttgccca                                                   20


<210> 15108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15108
cttacaggaa atccttgccc                                                   20


<210> 15109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15109
acttacagga aatccttgcc                                                   20


<210> 15110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15110
agggcaggca ttccacttac                                                   20


<210> 15111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15111
tagggcaggc attccactta                                                   20


<210> 15112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15112
aaatatatac ctactagggc                                                   20


<210> 15113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15113
aaaatatata cctactaggg                                                   20


<210> 15114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15114
tttaaaatat atacctacta                                                   20


<210> 15115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15115
atttaaaata tatacctact                                                   20


<210> 15116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15116
aatttaaaat atatacctac                                                   20


<210> 15117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15117
tggcagcgcc tcaagagcac                                                   20


<210> 15118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15118
tgtgactggc agcgcctcaa                                                   20


<210> 15119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15119
agtgtgactg gcagcgcctc                                                   20


<210> 15120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15120
gcagagggga gtgtgactgg                                                   20


<210> 15121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15121
acagcagagg ggagtgtgac                                                   20


<210> 15122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15122
ggcactgtaa cagcagaggg                                                   20


<210> 15123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15123
ctggcactgt aacagcagag                                                   20


<210> 15124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15124
tctggcactg taacagcaga                                                   20


<210> 15125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15125
ttctggcact gtaacagcag                                                   20


<210> 15126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15126
tttctggcac tgtaacagca                                                   20


<210> 15127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15127
agtttctggc actgtaacag                                                   20


<210> 15128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15128
tgcagtttct ggcactgtaa                                                   20


<210> 15129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15129
aactttggtg gtgcagtttc                                                   20


<210> 15130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15130
ataagacaac tttggtggtg                                                   20


<210> 15131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15131
tgagcataag acaactttgg                                                   20


<210> 15132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15132
cactgagcat aagacaactt                                                   20


<210> 15133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15133
gaacaaagat cactgagcat                                                   20


<210> 15134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15134
aatcctgaac aaagatcact                                                   20


<210> 15135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15135
ggtaaacaaa atcctgaaca                                                   20


<210> 15136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15136
actctctgga ttgtggtgag                                                   20


<210> 15137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15137
tactctctgg attgtggtga                                                   20


<210> 15138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15138
ctactctctg gattgtggtg                                                   20


<210> 15139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15139
cctactctct ggattgtggt                                                   20


<210> 15140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15140
aatacctact ctctggattg                                                   20


<210> 15141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15141
ggctaataat acctactctc                                                   20


<210> 15142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15142
gttttctcat tcattcaatg                                                   20


<210> 15143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15143
agttttctca ttcattcaat                                                   20


<210> 15144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15144
cagttttctc attcattcaa                                                   20


<210> 15145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15145
ttttaaaccc ctctgagtct                                                   20


<210> 15146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15146
gcaatatttt aaacccctct                                                   20


<210> 15147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15147
tacttgtgga tggctcatgc                                                   20


<210> 15148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15148
ctgactcaac tacttgtgga                                                   20


<210> 15149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15149
attcctgact caactacttg                                                   20


<210> 15150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15150
cacagagtac atgcaaacct                                                   20


<210> 15151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15151
tcacagagta catgcaaacc                                                   20


<210> 15152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15152
ggctacatgg ataagtcaca                                                   20


<210> 15153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15153
ggggctacat ggataagtca                                                   20


<210> 15154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15154
agaaaagggg ctacatggat                                                   20


<210> 15155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15155
ccgagagaaa aggggctaca                                                   20


<210> 15156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15156
ctgagatccc gagagaaaag                                                   20


<210> 15157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15157
actgagatcc cgagagaaaa                                                   20


<210> 15158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15158
aactgagatc ccgagagaaa                                                   20


<210> 15159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15159
taactgagat cccgagagaa                                                   20


<210> 15160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15160
ttgcgtaact gagatcccga                                                   20


<210> 15161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15161
atttgcgtaa ctgagatccc                                                   20


<210> 15162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15162
tgttctagat ttgcgtaact                                                   20


<210> 15163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15163
gaggtagata ggcgctgttc                                                   20


<210> 15164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15164
tccatacccc tgaggtagat                                                   20


<210> 15165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15165
ttccataccc ctgaggtaga                                                   20


<210> 15166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15166
tgccttccat acccctgagg                                                   20


<210> 15167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15167
taatgccttc catacccctg                                                   20


<210> 15168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15168
ttaatgcctt ccatacccct                                                   20


<210> 15169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15169
gtcagggcaa taaaggtata                                                   20


<210> 15170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15170
agaaaatgtc agggcaataa                                                   20


<210> 15171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15171
aagaaaatgt cagggcaata                                                   20


<210> 15172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15172
atgtttataa gaaaatgtca                                                   20


<210> 15173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15173
catgtttata agaaaatgtc                                                   20


<210> 15174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15174
tcatgtttat aagaaaatgt                                                   20


<210> 15175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15175
agataacctc tcatgtttat                                                   20


<210> 15176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15176
gattaatagg aatcgaatcc                                                   20


<210> 15177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15177
gggtgccgac tctgattaat                                                   20


<210> 15178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15178
agggtgccga ctctgattaa                                                   20


<210> 15179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15179
aggaaggctt gtgcctccaa                                                   20


<210> 15180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15180
gaggaaggct tgtgcctcca                                                   20


<210> 15181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15181
ggaggaaggc ttgtgcctcc                                                   20


<210> 15182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15182
cctccttggg atggggagga                                                   20


<210> 15183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15183
ccctccttgg gatggggagg                                                   20


<210> 15184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15184
caaccctcct tgggatgggg                                                   20


<210> 15185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15185
ccaaccctcc ttgggatggg                                                   20


<210> 15186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15186
tcccaaccct ccttgggatg                                                   20


<210> 15187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15187
atcccaaccc tccttgggat                                                   20


<210> 15188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15188
aatcccaacc ctccttggga                                                   20


<210> 15189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15189
gcagaatccc aaccctcctt                                                   20


<210> 15190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15190
ggcagaatcc caaccctcct                                                   20


<210> 15191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15191
aggccatggc ccagcactgg                                                   20


<210> 15192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15192
gaaaggccat ggcccagcac                                                   20


<210> 15193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15193
cctcaggaaa ggccatggcc                                                   20


<210> 15194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15194
gggcacctca ggaaaggcca                                                   20


<210> 15195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15195
gagtcagggc acctcaggaa                                                   20


<210> 15196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15196
tgagtcaggg cacctcagga                                                   20


<210> 15197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15197
ggactgagtc agggcacctc                                                   20


<210> 15198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15198
aggactgagt cagggcacct                                                   20


<210> 15199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15199
ccccacaaag gactgagtca                                                   20


<210> 15200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15200
tccccacaaa ggactgagtc                                                   20


<210> 15201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15201
atccccacaa aggactgagt                                                   20


<210> 15202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15202
tatgatcccc acaaaggact                                                   20


<210> 15203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15203
gggggatatg atccccacaa                                                   20


<210> 15204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15204
tgggggatat gatccccaca                                                   20


<210> 15205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15205
agaacttgct gacctgttgg                                                   20


<210> 15206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15206
tagaacttgc tgacctgttg                                                   20


<210> 15207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15207
ctagaacttg ctgacctgtt                                                   20


<210> 15208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15208
tctagaactt gctgacctgt                                                   20


<210> 15209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15209
agcagggaaa gaaagggatc                                                   20


<210> 15210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15210
aatacaagca gggaaagaaa                                                   20


<210> 15211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15211
gaatacaagc agggaaagaa                                                   20


<210> 15212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15212
agaatacaag cagggaaaga                                                   20


<210> 15213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15213
tgggagaata caagcaggga                                                   20


<210> 15214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15214
gccctgggag aatacaagca                                                   20


<210> 15215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15215
agccctggga gaatacaagc                                                   20


<210> 15216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15216
gagccctggg agaatacaag                                                   20


<210> 15217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15217
agtgagccct gggagaatac                                                   20


<210> 15218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15218
gtgttccaag tgagccctgg                                                   20


<210> 15219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15219
atgtgttcca agtgagccct                                                   20


<210> 15220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15220
gatgtgttcc aagtgagccc                                                   20


<210> 15221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15221
gtgttagatg tgttccaagt                                                   20


<210> 15222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15222
aggtgtgtta gatgtgttcc                                                   20


<210> 15223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15223
ccaactggaa ccaggtgtgt                                                   20


<210> 15224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15224
tggtcttccc aactggaacc                                                   20


<210> 15225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15225
ttggtcttcc caactggaac                                                   20


<210> 15226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15226
gggatcttgg tcttcccaac                                                   20


<210> 15227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15227
ttcacatctc aaagggatct                                                   20


<210> 15228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15228
ctcaggattc acatctcaaa                                                   20


<210> 15229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15229
actcaggatt cacatctcaa                                                   20


<210> 15230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15230
cactcaggat tcacatctca                                                   20


<210> 15231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15231
ccccactaac atcctcactc                                                   20


<210> 15232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15232
gccccactaa catcctcact                                                   20


<210> 15233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15233
agagttgcat ttctctctgt                                                   20


<210> 15234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15234
tgtgattgct gttgcaggaa                                                   20


<210> 15235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15235
cctgtgattg ctgttgcagg                                                   20


<210> 15236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15236
tgccctgtga ttgctgttgc                                                   20


<210> 15237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15237
ttgccctgtg attgctgttg                                                   20


<210> 15238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15238
acagcccatc actttaatat                                                   20


<210> 15239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15239
acaaaagcca acactactca                                                   20


<210> 15240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15240
cagctctggc ctcctgacaa                                                   20


<210> 15241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15241
tcctgttccc tgcccagctc                                                   20


<210> 15242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15242
tatatttcct gttccctgcc                                                   20


<210> 15243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15243
ctggtttctg ctgtagtggt                                                   20


<210> 15244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15244
gtttctggtt tctgctgtag                                                   20


<210> 15245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15245
ggagtttctg gtttctgctg                                                   20


<210> 15246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15246
aagtggtgct caggagtttc                                                   20


<210> 15247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15247
aaaagataag tggtgctcag                                                   20


<210> 15248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15248
aaaaaagata agtggtgctc                                                   20


<210> 15249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15249
aaaaaaagat aagtggtgct                                                   20


<210> 15250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15250
caacagaaaa aaaagataag                                                   20


<210> 15251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15251
aatcaacaga aaaaaaagat                                                   20


<210> 15252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15252
acttcaatca acagaaaaaa                                                   20


<210> 15253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15253
taattgacaa cttcaatcaa                                                   20


<210> 15254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15254
cacactgaat ctctttgttg                                                   20


<210> 15255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15255
tcacactgaa tctctttgtt                                                   20


<210> 15256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15256
ttcacactga atctctttgt                                                   20


<210> 15257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15257
gtcatcttca tcatttttgg                                                   20


<210> 15258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15258
tgtcatcttc atcatttttg                                                   20


<210> 15259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15259
tttgtcatct tcatcatttt                                                   20


<210> 15260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15260
caacatgcaa cccaagtggg                                                   20


<210> 15261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15261
tcaacatgca acccaagtgg                                                   20


<210> 15262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15262
ggtcaacatg caacccaagt                                                   20


<210> 15263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15263
aggtcaacat gcaacccaag                                                   20


<210> 15264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15264
cacaggtcaa catgcaaccc                                                   20


<210> 15265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15265
actctccctt gtctggtcac                                                   20


<210> 15266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15266
cactctccct tgtctggtca                                                   20


<210> 15267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15267
ccttcccact ctcccttgtc                                                   20


<210> 15268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15268
tttcagagtg aacctgaact                                                   20


<210> 15269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15269
tgtcttaggc ttggctttca                                                   20


<210> 15270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15270
catgtcttag gcttggcttt                                                   20


<210> 15271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15271
ccaggtccat gtcttaggct                                                   20


<210> 15272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15272
tgcacccagg tccatgtctt                                                   20


<210> 15273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15273
ctgcacccag gtccatgtct                                                   20


<210> 15274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15274
cagataaatc acctgcaccc                                                   20


<210> 15275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15275
ccagataaat cacctgcacc                                                   20


<210> 15276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15276
tgcttccttg gatcacctcc                                                   20


<210> 15277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15277
ctccctcatt cctgcttcct                                                   20


<210> 15278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15278
cttaacaaca tcctcttcac                                                   20


<210> 15279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15279
gcttaacaac atcctcttca                                                   20


<210> 15280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15280
accccagtag gattgcgctt                                                   20


<210> 15281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15281
gttactcaga ggaccccagt                                                   20


<210> 15282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15282
agttactcag aggaccccag                                                   20


<210> 15283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15283
cacagttact cagaggaccc                                                   20


<210> 15284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15284
tgctctacac agttactcag                                                   20


<210> 15285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15285
gtgctctaca cagttactca                                                   20


<210> 15286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15286
atgtgctcta cacagttact                                                   20


<210> 15287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15287
aatcctgcat gtgctctaca                                                   20


<210> 15288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15288
actccagttt ccctgtccct                                                   20


<210> 15289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15289
gagtctgagg ataaatactc                                                   20


<210> 15290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15290
caataagttt tgggagtctg                                                   20


<210> 15291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15291
ccaataagtt ttgggagtct                                                   20


<210> 15292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15292
cccttaccaa taagttttgg                                                   20


<210> 15293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15293
aacccttacc aataagtttt                                                   20


<210> 15294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15294
caacccttac caataagttt                                                   20


<210> 15295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15295
taggggcaac ccttaccaat                                                   20


<210> 15296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15296
cagggattta atgtccctag                                                   20


<210> 15297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15297
ccagggattt aatgtcccta                                                   20


<210> 15298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15298
accagggatt taatgtccct                                                   20


<210> 15299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15299
taccagggat ttaatgtccc                                                   20


<210> 15300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15300
aacttctccc ccaagtacca                                                   20


<210> 15301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15301
caacttctcc cccaagtacc                                                   20


<210> 15302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15302
gcaacttctc ccccaagtac                                                   20


<210> 15303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15303
tgtgcagcaa cttctccccc                                                   20


<210> 15304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15304
ccagggctta ggagcttgtg                                                   20


<210> 15305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15305
ataaagactc cagggcttag                                                   20


<210> 15306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15306
gtataaagac tccagggctt                                                   20


<210> 15307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15307
tgtataaaga ctccagggct                                                   20


<210> 15308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15308
ttctctgtat aaagactcca                                                   20


<210> 15309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15309
attctctgta taaagactcc                                                   20


<210> 15310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15310
gattctctgt ataaagactc                                                   20


<210> 15311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15311
cacttctgat tctctgtata                                                   20


<210> 15312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15312
ccacttctga tttcacctgc                                                   20


<210> 15313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15313
cccacttctg atttcacctg                                                   20


<210> 15314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15314
ttccctgcca cctcttccct                                                   20


<210> 15315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15315
tgaccacttc ctgctgtggc                                                   20


<210> 15316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15316
atgaccactt cctgctgtgg                                                   20


<210> 15317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15317
ggaatgacca cttcctgctg                                                   20


<210> 15318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15318
aggctgggga gacactattg                                                   20


<210> 15319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15319
caggctgggg agacactatt                                                   20


<210> 15320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15320
ccaggctggg gagacactat                                                   20


<210> 15321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15321
aaagaaaaag ccaggctggg                                                   20


<210> 15322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15322
gaaaagaaaa agccaggctg                                                   20


<210> 15323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15323
agaaaagaaa aagccaggct                                                   20


<210> 15324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15324
aagaaaagaa aaagccaggc                                                   20


<210> 15325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15325
agaaaagaaa agaaaaagcc                                                   20


<210> 15326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15326
aagaaaagaa aagaaaaagc                                                   20


<210> 15327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15327
aaaaaagaaa agaaaagaaa                                                   20


<210> 15328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15328
ctcaaaaaaa aagaaaagaa                                                   20


<210> 15329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15329
tcaatctcaa aaaaaaagaa                                                   20


<210> 15330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15330
gagactcaat ctcaaaaaaa                                                   20


<210> 15331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15331
tccagcttgg gcgagacagc                                                   20


<210> 15332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15332
gcactccagc ttgggcgaga                                                   20


<210> 15333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15333
cactgcactc cagcttgggc                                                   20


<210> 15334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15334
gcgtcactgc actccagctt                                                   20


<210> 15335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15335
tgcgtcactg cactccagct                                                   20


<210> 15336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15336
gagattgcgt cactgcactc                                                   20


<210> 15337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15337
ggcagaagtt gcagtgagct                                                   20


<210> 15338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15338
cgggaggcag aagttgcagt                                                   20


<210> 15339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15339
aacccgggag gcagaagttg                                                   20


<210> 15340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15340
ctcttgaacc cgggaggcag                                                   20


<210> 15341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15341
aatctcttga acccgggagg                                                   20


<210> 15342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15342
gagaatctct tgaacccggg                                                   20


<210> 15343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15343
ggagaatctc ttgaacccgg                                                   20


<210> 15344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15344
caggagaatc tcttgaaccc                                                   20


<210> 15345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 15345
acaggagaat ctcttgaacc                                                   20


<210> 15346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15346
tgctcgggag actgagacag                                                   20


<210> 15347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15347
gctgctcggg agactgagac                                                   20


<210> 15348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15348
agctgctcgg gagactgaga                                                   20


<210> 15349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15349
tcccagctgc tcgggagact                                                   20


<210> 15350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15350
ctgtagtccc agctgctcgg                                                   20


<210> 15351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15351
gcctgtagtc ccagctgctc                                                   20


<210> 15352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 15352
tgcctgtagt cccagctgct                                                   20


<210> 15353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15353
gcggcttgtg cctgtagtcc                                                   20


<210> 15354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15354
ggcatggcgg cttgtgcctg                                                   20


<210> 15355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 15355
aagaaattag cagggcatgg                                                   20


<210> 15356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15356
tgaaagaaat tagcagggca                                                   20


<210> 15357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15357
aaatatgaaa gaaattagca                                                   20


<210> 15358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15358
aaaatatgaa agaaattagc                                                   20


<210> 15359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15359
taaaatatga aagaaattag                                                   20


<210> 15360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15360
tactaaaata tgaaagaaat                                                   20


<210> 15361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15361
ccatctctac taaaatatga                                                   20


<210> 15362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 15362
ggagaccagc ctgggcaata                                                   20


<210> 15363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15363
tgagctcagg agaccagcct                                                   20


<210> 15364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15364
ctgagctcag gagaccagcc                                                   20


<210> 15365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15365
attgcctgag ctcaggagac                                                   20


<210> 15366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15366
ggcagattgc ctgagctcag                                                   20


<210> 15367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15367
tgggcagatt gcctgagctc                                                   20


<210> 15368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15368
gtgggcagat tgcctgagct                                                   20


<210> 15369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15369
ccgaggtggg cagattgcct                                                   20


<210> 15370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15370
ctttgggagg ccgaggtggg                                                   20


<210> 15371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15371
gcactttggg aggccgaggt                                                   20


<210> 15372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15372
agcactttgg gaggccgagg                                                   20


<210> 15373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15373
cctagcactt tgggaggccg                                                   20


<210> 15374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15374
tcctagcact ttgggaggcc                                                   20


<210> 15375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15375
tgtaatccta gcactttggg                                                   20


<210> 15376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15376
ctgtaatcct agcactttgg                                                   20


<210> 15377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15377
gcctgtaatc ctagcacttt                                                   20


<210> 15378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15378
tgcctgtaat cctagcactt                                                   20


<210> 15379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15379
gtggttcatg cctgtaatcc                                                   20


<210> 15380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15380
ccaggatggg ccaggcgcag                                                   20


<210> 15381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15381
aacccaggat gggccaggcg                                                   20


<210> 15382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15382
cataaaaccc aggatgggcc                                                   20


<210> 15383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15383
tcataaaacc caggatgggc                                                   20


<210> 15384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15384
actatcataa aacccaggat                                                   20


<210> 15385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15385
aactatcata aaacccagga                                                   20


<210> 15386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15386
caggaactat cataaaaccc                                                   20


<210> 15387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15387
tcaggaacta tcataaaacc                                                   20


<210> 15388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15388
gaggaatgag gtagaatctc                                                   20


<210> 15389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15389
ggaggaatga ggtagaatct                                                   20


<210> 15390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15390
gtgcataggg aggaatgagg                                                   20


<210> 15391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15391
aaggtgcata gggaggaatg                                                   20


<210> 15392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15392
caaggtgcat agggaggaat                                                   20


<210> 15393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15393
ctaaatcaag gtgcataggg                                                   20


<210> 15394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15394
gctaaatcaa ggtgcatagg                                                   20


<210> 15395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15395
tagctaaatc aaggtgcata                                                   20


<210> 15396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15396
gtagctaaat caaggtgcat                                                   20


<210> 15397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15397
agtagctaaa tcaaggtgca                                                   20


<210> 15398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15398
caagggtagt agctaaatca                                                   20


<210> 15399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15399
gcaagggtag tagctaaatc                                                   20


<210> 15400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15400
tgggagcaaa gcaagggtag                                                   20


<210> 15401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15401
gggtgggagc aaagcaaggg                                                   20


<210> 15402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15402
caagggtggg agcaaagcaa                                                   20


<210> 15403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15403
acaagggtgg gagcaaagca                                                   20


<210> 15404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15404
gacaagggtg ggagcaaagc                                                   20


<210> 15405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15405
cctggacaag ggtgggagca                                                   20


<210> 15406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15406
cactccctgg acaagggtgg                                                   20


<210> 15407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15407
gccactccct ggacaagggt                                                   20


<210> 15408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15408
agccactccc tggacaaggg                                                   20


<210> 15409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15409
gtgagccact ccctggacaa                                                   20


<210> 15410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15410
tgtgagccac tccctggaca                                                   20


<210> 15411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15411
atgtgagcca ctccctggac                                                   20


<210> 15412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15412
agttcatgtg agccactccc                                                   20


<210> 15413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15413
ctctaagaga cagttcatgt                                                   20


<210> 15414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15414
atcagataac ctctaagaga                                                   20


<210> 15415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15415
aagcatcaga taacctctaa                                                   20


<210> 15416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15416
gaaagcatca gataacctct                                                   20


<210> 15417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15417
ttcactgttg aggaaagcat                                                   20


<210> 15418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15418
cctctgttca ctgttgagga                                                   20


<210> 15419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15419
ttttcctctg ttcactgttg                                                   20


<210> 15420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15420
gttttcctct gttcactgtt                                                   20


<210> 15421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15421
tacactcccc aggcttctcg                                                   20


<210> 15422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15422
ctacactccc caggcttctc                                                   20


<210> 15423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15423
ccctttcatc tacactcccc                                                   20


<210> 15424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15424
cccctttcat ctacactccc                                                   20


<210> 15425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15425
gttgagtgtt tcagccaccg                                                   20


<210> 15426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15426
tgttgagtgt ttcagccacc                                                   20


<210> 15427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15427
tggctctctg ttgagtgttt                                                   20


<210> 15428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15428
tgtccagctg gctctctgtt                                                   20


<210> 15429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15429
tccttgcagc agtgtccagc                                                   20


<210> 15430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15430
tccctccttg cagcagtgtc                                                   20


<210> 15431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15431
cacactgtcc ctccttgcag                                                   20


<210> 15432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15432
cctcacactg tccctccttg                                                   20


<210> 15433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15433
tactggaaga ggcgatcacc                                                   20


<210> 15434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15434
gatgaccctg gtactggaag                                                   20


<210> 15435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15435
cgatgaccct ggtactggaa                                                   20


<210> 15436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15436
gacgatgacc ctggtactgg                                                   20


<210> 15437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15437
agtgacgatg accctggtac                                                   20


<210> 15438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15438
aaatgaagtg acgatgaccc                                                   20


<210> 15439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15439
atcagtctgc atttgaaatg                                                   20


<210> 15440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15440
tctgtgcatt ctacccatat                                                   20


<210> 15441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15441
gtctcagccc actgtcccta                                                   20


<210> 15442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15442
gattcccggg aggtgagtct                                                   20


<210> 15443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15443
gctgttgatt cccgggaggt                                                   20


<210> 15444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15444
tgcagctgtt gattcccggg                                                   20


<210> 15445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15445
atgcagctgt tgattcccgg                                                   20


<210> 15446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15446
gtatgcagct gttgattccc                                                   20


<210> 15447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 15447
tgtatgcagc tgttgattcc                                                   20


<210> 15448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15448
ctggatggac attatgtatg                                                   20


<210> 15449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15449
ggcaaccttt aaaggctgga                                                   20


<210> 15450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15450
tccaggcaac ctttaaaggc                                                   20


<210> 15451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15451
tgtctccagg caacctttaa                                                   20


<210> 15452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15452
ttgtctccag gcaaccttta                                                   20


<210> 15453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15453
ggcctctgct ccttgtctcc                                                   20


<210> 15454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15454
tggcctctgc tccttgtctc                                                   20


<210> 15455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15455
atggatgggc agacactgag                                                   20


<210> 15456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15456
tagatggatg ggcagacact                                                   20


<210> 15457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15457
gtccagtata gatggatggg                                                   20


<210> 15458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15458
agggtccagt atagatggat                                                   20


<210> 15459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15459
aagggtccag tatagatgga                                                   20


<210> 15460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15460
tgggaagggt ccagtataga                                                   20


<210> 15461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15461
ggcttgggaa gggtccagta                                                   20


<210> 15462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15462
accatggctt gggaagggtc                                                   20


<210> 15463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15463
gggccaccat ggcttgggaa                                                   20


<210> 15464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15464
tgggccacca tggcttggga                                                   20


<210> 15465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15465
ctgggccacc atggcttggg                                                   20


<210> 15466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15466
tcactgggcc accatggctt                                                   20


<210> 15467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15467
ctcactgggc caccatggct                                                   20


<210> 15468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15468
cctctctcac tgggccacca                                                   20


<210> 15469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15469
ggactctctc ctctctcact                                                   20


<210> 15470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15470
aggactctct cctctctcac                                                   20


<210> 15471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15471
gcacaagccc tttccaacac                                                   20


<210> 15472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15472
tgcacaagcc ctttccaaca                                                   20


<210> 15473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15473
tcctttcatt ctttctgcac                                                   20


<210> 15474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15474
agattagtca agtaacccaa                                                   20


<210> 15475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15475
gagattagtc aagtaaccca                                                   20


<210> 15476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15476
tgagattagt caagtaaccc                                                   20


<210> 15477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15477
atcatcatat gagattagtc                                                   20


<210> 15478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15478
tttaaatcat catatgagat                                                   20


<210> 15479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15479
attactttaa atcatcatat                                                   20


<210> 15480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15480
attcttaaac agccacatgt                                                   20


<210> 15481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15481
tattcttaaa cagccacatg                                                   20


<210> 15482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15482
aatgctactc tattcttaaa                                                   20


<210> 15483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15483
agtccatact acattctgaa                                                   20


<210> 15484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15484
cagtccatac tacattctga                                                   20


<210> 15485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15485
acacctagac actcagtcct                                                   20


<210> 15486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15486
gaaccagaca cctagacact                                                   20


<210> 15487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15487
tggcactaga accagacacc                                                   20


<210> 15488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15488
gtagcaattg gcactagaac                                                   20


<210> 15489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15489
agacttgtag caattggcac                                                   20


<210> 15490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15490
cagagcagac ttgtagcaat                                                   20


<210> 15491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15491
aagtgcacag agcagacttg                                                   20


<210> 15492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15492
ccttaggcaa gtgcacagag                                                   20


<210> 15493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15493
aaaccttagg caagtgcaca                                                   20


<210> 15494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15494
ggaaacctta ggcaagtgca                                                   20


<210> 15495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15495
tgagagggga aaccttaggc                                                   20


<210> 15496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15496
gccctgagag gggaaacctt                                                   20


<210> 15497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15497
agccctgaga ggggaaacct                                                   20


<210> 15498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15498
gaaaatggca gccctgagag                                                   20


<210> 15499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15499
agaaaatggc agccctgaga                                                   20


<210> 15500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15500
gagaaaatgg cagccctgag                                                   20


<210> 15501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15501
tgagaaaatg gcagccctga                                                   20


<210> 15502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15502
gctgagaaaa tggcagccct                                                   20


<210> 15503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15503
gaaagtggct gagaaaatgg                                                   20


<210> 15504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15504
tgggaaagtg gctgagaaaa                                                   20


<210> 15505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15505
cataaggtgg gaaagtggct                                                   20


<210> 15506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15506
atgtgcataa ggtgggaaag                                                   20


<210> 15507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15507
atcatgtgca taaggtggga                                                   20


<210> 15508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15508
ttacatcatg tgcataaggt                                                   20


<210> 15509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15509
cttacatcat gtgcataagg                                                   20


<210> 15510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15510
attcttacat catgtgcata                                                   20


<210> 15511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15511
cattcttaca tcatgtgcat                                                   20


<210> 15512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15512
ttctcaactt ctccatctgg                                                   20


<210> 15513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15513
ctattctcaa cttctccatc                                                   20


<210> 15514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15514
agctgaaggc aggaacatgg                                                   20


<210> 15515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15515
aagctgaagg caggaacatg                                                   20


<210> 15516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15516
taaagctgaa ggcaggaaca                                                   20


<210> 15517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15517
agaatgctaa agctgaaggc                                                   20


<210> 15518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15518
aagaatgcta aagctgaagg                                                   20


<210> 15519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15519
ctcaagaatg ctaaagctga                                                   20


<210> 15520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15520
cctcaagaat gctaaagctg                                                   20


<210> 15521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15521
tctagacctc aagaatgcta                                                   20


<210> 15522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15522
acacccagtt tctagacctc                                                   20


<210> 15523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15523
tggaaggcac acccagtttc                                                   20


<210> 15524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15524
aacatgctgg aaggcacacc                                                   20


<210> 15525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15525
catgctctga acatgctgga                                                   20


<210> 15526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15526
gcatgctctg aacatgctgg                                                   20


<210> 15527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15527
cttgcatgct ctgaacatgc                                                   20


<210> 15528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15528
ggcctaggag tgtaagaact                                                   20


<210> 15529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15529
tgtaacaggc ctaggagtgt                                                   20


<210> 15530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15530
aagtgctgta acaggcctag                                                   20


<210> 15531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15531
ttaagtgctg taacaggcct                                                   20


<210> 15532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15532
attaagtgct gtaacaggcc                                                   20


<210> 15533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15533
agctcattaa gtgctgtaac                                                   20


<210> 15534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15534
cagctcatta agtgctgtaa                                                   20


<210> 15535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15535
gtgaattaaa acagctcatt                                                   20


<210> 15536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15536
gactaatagg tgaattaaaa                                                   20


<210> 15537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15537
tgtatgagaa acagactaat                                                   20


<210> 15538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15538
ctgtatgaga aacagactaa                                                   20


<210> 15539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15539
cactgatgct gtatgagaaa                                                   20


<210> 15540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15540
cttggacact gatgctgtat                                                   20


<210> 15541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15541
gatacagtca gaactgggct                                                   20


<210> 15542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15542
tgggagatac agtcagaact                                                   20


<210> 15543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15543
ctgggagata cagtcagaac                                                   20


<210> 15544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15544
tcagccctgg gagatacagt                                                   20


<210> 15545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15545
ctactcagcc ctgggagata                                                   20


<210> 15546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15546
atggtactac tcagccctgg                                                   20


<210> 15547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15547
gcatggtact actcagccct                                                   20


<210> 15548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15548
ggcatggtac tactcagccc                                                   20


<210> 15549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15549
atgccaggca tggtactact                                                   20


<210> 15550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15550
tagctctggt atgccaggca                                                   20


<210> 15551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15551
ctgagtagct ctggtatgcc                                                   20


<210> 15552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15552
tctgagtagc tctggtatgc                                                   20


<210> 15553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15553
aaataatctc tgagtagctc                                                   20


<210> 15554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15554
ttcaacaaat aatctctgag                                                   20


<210> 15555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15555
ttattcaaca aataatctct                                                   20


<210> 15556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15556
gagtgtctac attccaccat                                                   20


<210> 15557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15557
tttgtcatgc agttactctt                                                   20


<210> 15558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15558
ttacttatac atttgtcatg                                                   20


<210> 15559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15559
attcagtcct ctgttcattc                                                   20


<210> 15560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15560
ccttcatcta cctgttcatt                                                   20


<210> 15561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15561
tctttctttc tttcatcatc                                                   20


<210> 15562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15562
tataatgttg gtgataatga                                                   20


<210> 15563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15563
attgtaatga tatataatgt                                                   20


<210> 15564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15564
gtaataaatt atgtctcatt                                                   20


<210> 15565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15565
ggtaataaat tatgtctcat                                                   20


<210> 15566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15566
acttcacatc atttcctaaa                                                   20


<210> 15567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15567
acacggcata gccacatgtt                                                   20


<210> 15568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15568
tgtacaaaat agacacggca                                                   20


<210> 15569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 15569
gaacctgtac aaaatagaca                                                   20


<210> 15570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15570
aacacagaac ctgtacaaaa                                                   20


<210> 15571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15571
tcaggtggtg agttaaaaca                                                   20


<210> 15572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15572
ccatgggatt atcaggtggt                                                   20


<210> 15573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15573
cctgccatgg gattatcagg                                                   20


<210> 15574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15574
gggcctgcca tgggattatc                                                   20


<210> 15575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15575
tgggcctgcc atgggattat                                                   20


<210> 15576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15576
taaagggatg ggcctgccat                                                   20


<210> 15577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15577
ataaagggat gggcctgcca                                                   20


<210> 15578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15578
gtagaatagc ataaagggat                                                   20


<210> 15579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15579
agtagaatag cataaaggga                                                   20


<210> 15580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15580
ggctagtaga atagcataaa                                                   20


<210> 15581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15581
gggctagtag aatagcataa                                                   20


<210> 15582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15582
tgggctagta gaatagcata                                                   20


<210> 15583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15583
acaagtgtgg gctagtagaa                                                   20


<210> 15584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15584
attacacaag tgtgggctag                                                   20


<210> 15585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15585
gcaattacac aagtgtgggc                                                   20


<210> 15586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15586
tggtgcaatt acacaagtgt                                                   20


<210> 15587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15587
gtggtgcaat tacacaagtg                                                   20


<210> 15588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15588
tcacagtggt gcaattacac                                                   20


<210> 15589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15589
tagtgaatat gatatcacag                                                   20


<210> 15590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15590
tcctagtgaa tatgatatca                                                   20


<210> 15591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15591
atgaggctag agggccttcc                                                   20


<210> 15592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15592
gactacacca tgaggctaga                                                   20


<210> 15593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15593
agactacacc atgaggctag                                                   20


<210> 15594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15594
cagactacac catgaggcta                                                   20


<210> 15595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15595
tacagactac accatgaggc                                                   20


<210> 15596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15596
ttcctacaga ctacaccatg                                                   20


<210> 15597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15597
attcctacag actacaccat                                                   20


<210> 15598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15598
gaggtcattc tctattccta                                                   20


<210> 15599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15599
gtagcactca gtgtgaactg                                                   20


<210> 15600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15600
agtagcactc agtgtgaact                                                   20


<210> 15601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15601
actttgcaag gagtagcact                                                   20


<210> 15602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15602
tgtggggact ttgcaaggag                                                   20


<210> 15603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15603
ctatgtgggg actttgcaag                                                   20


<210> 15604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15604
tgctatgtgg ggactttgca                                                   20


<210> 15605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15605
atgctatgtg gggactttgc                                                   20


<210> 15606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15606
ttcccagaag atgctatgtg                                                   20


<210> 15607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15607
gttcccagaa gatgctatgt                                                   20


<210> 15608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15608
ggttcccaga agatgctatg                                                   20


<210> 15609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15609
tggagagtct aggttcccag                                                   20


<210> 15610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15610
aaatggagag tctaggttcc                                                   20


<210> 15611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15611
ctcaataaaa tggagagtct                                                   20


<210> 15612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15612
gctcaataaa atggagagtc                                                   20


<210> 15613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15613
tggccgctca ataaaatgga                                                   20


<210> 15614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15614
tttggccgct caataaaatg                                                   20


<210> 15615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15615
gctttggccg ctcaataaaa                                                   20


<210> 15616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15616
atcaaccata tctcttgctt                                                   20


<210> 15617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15617
gcaggtggtg agtcaaccat                                                   20


<210> 15618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15618
cttgcacttc tgcaggtggt                                                   20


<210> 15619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15619
ttaccttgca cttctgcagg                                                   20


<210> 15620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15620
gggttacctt gcacttctgc                                                   20


<210> 15621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15621
tgggttacct tgcacttctg                                                   20


<210> 15622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15622
aactttgata atgttgcaat                                                   20


<210> 15623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15623
caactttgat aatgttgcaa                                                   20


<210> 15624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15624
cttcttctgg gtcaatgtga                                                   20


<210> 15625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15625
ctccactggc agcttcttct                                                   20


<210> 15626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15626
actccactgg cagcttcttc                                                   20


<210> 15627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15627
aagattcaaa actccactgg                                                   20


<210> 15628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15628
tgcaagattc aaaactccac                                                   20


<210> 15629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15629
tgaataacaa gtctgactgc                                                   20


<210> 15630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15630
ctttgtcgat tgtgaataac                                                   20


<210> 15631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15631
gcatcaacta taccgatgga                                                   20


<210> 15632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15632
gtgcatcaac tataccgatg                                                   20


<210> 15633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15633
aggtgcatca actataccga                                                   20


<210> 15634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15634
tcttcgcagg gaagttttgg                                                   20


<210> 15635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15635
ctcttcgcag ggaagttttg                                                   20


<210> 15636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15636
acctcttcgc agggaagttt                                                   20


<210> 15637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15637
gtgtgaacct cttcgcaggg                                                   20


<210> 15638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15638
tgggtgtgaa cctcttcgca                                                   20


<210> 15639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15639
atgggtgtga acctcttcgc                                                   20


<210> 15640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15640
catgggtgtg aacctcttcg                                                   20


<210> 15641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15641
tggctcatct tcagcatcat                                                   20


<210> 15642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15642
ctggctcatc ttcagcatca                                                   20


<210> 15643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15643
ctcatcttct ggctcatctt                                                   20


<210> 15644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15644
tcctcgtctg cctcatcttc                                                   20


<210> 15645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15645
gtggtggtgg atgccctggt                                                   20


<210> 15646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15646
ggtggtggtg gatgccctgg                                                   20


<210> 15647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15647
ccaggtggtg gtggatgccc                                                   20


<210> 15648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15648
tatctcccac caggtggtgg                                                   20


<210> 15649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15649
ctctatctcc caccaggtgg                                                   20


<210> 15650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15650
tttctctatc tcccaccagg                                                   20


<210> 15651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15651
gtctttctct atctcccacc                                                   20


<210> 15652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15652
ggtctttctc tatctcccac                                                   20


<210> 15653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15653
gtggggcatt gggaggttcc                                                   20


<210> 15654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15654
ggtggggcat tgggaggttc                                                   20


<210> 15655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15655
agagggggtg gggcattggg                                                   20


<210> 15656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15656
cagagggggt ggggcattgg                                                   20


<210> 15657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15657
agcagagggg gtggggcatt                                                   20


<210> 15658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15658
cagcagaggg ggtggggcat                                                   20


<210> 15659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15659
agaatccagc agagggggtg                                                   20


<210> 15660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15660
tagaatccag cagagggggt                                                   20


<210> 15661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15661
atagaatcca gcagaggggg                                                   20


<210> 15662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15662
gagatagaat ccagcagagg                                                   20


<210> 15663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15663
agagatagaa tccagcagag                                                   20


<210> 15664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15664
aagagataga atccagcaga                                                   20


<210> 15665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15665
aaagagatag aatccagcag                                                   20


<210> 15666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15666
gaaagagata gaatccagca                                                   20


<210> 15667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15667
tagaaagaga tagaatccag                                                   20


<210> 15668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15668
gtatagaaag agatagaatc                                                   20


<210> 15669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15669
tgaatgagta tagaaagaga                                                   20


<210> 15670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15670
agcctgaatg agtatagaaa                                                   20


<210> 15671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15671
gcagcctgaa tgagtataga                                                   20


<210> 15672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15672
tgaagcagcc tgaatgagta                                                   20


<210> 15673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15673
gctcatgaag cagcctgaat                                                   20


<210> 15674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15674
aaggccactg gctcatgaag                                                   20


<210> 15675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15675
ccaaaggcca ctggctcatg                                                   20


<210> 15676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15676
ttgcttcttc caaaggccac                                                   20


<210> 15677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15677
acttctcttg cttcttccaa                                                   20


<210> 15678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15678
cacttctctt gcttcttcca                                                   20


<210> 15679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15679
ccaatgtctc tcagtcttct                                                   20


<210> 15680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15680
ttcagctgcc caatgtctct                                                   20


<210> 15681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15681
agaaggtcta aatccatctt                                                   20


<210> 15682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15682
tgaatgaggt taagggaaga                                                   20


<210> 15683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15683
ctgaatgagg ttaagggaag                                                   20


<210> 15684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15684
accctgaatg aggttaaggg                                                   20


<210> 15685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15685
cccaccctga atgaggttaa                                                   20


<210> 15686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15686
acccaccctg aatgaggtta                                                   20


<210> 15687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15687
aacccaccct gaatgaggtt                                                   20


<210> 15688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15688
actgcaaccc accctgaatg                                                   20


<210> 15689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15689
cactgcaacc caccctgaat                                                   20


<210> 15690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15690
ctcacacttc taaatgagtg                                                   20


<210> 15691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15691
acacactcac acttctaaat                                                   20


<210> 15692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15692
ttctagaagt ctgtatgtgc                                                   20


<210> 15693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15693
agaataagtc aaggttctag                                                   20


<210> 15694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15694
aggagaataa gtcaaggttc                                                   20


<210> 15695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15695
tatttaagga gaataagtca                                                   20


<210> 15696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15696
gtatttaagg agaataagtc                                                   20


<210> 15697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15697
gtatggtatt taaggagaat                                                   20


<210> 15698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15698
ttttatgtat ggtatttaag                                                   20


<210> 15699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15699
tgttttatgt atggtattta                                                   20


<210> 15700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15700
gtgttttatg tatggtattt                                                   20


<210> 15701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15701
ttgtgtttgt gttttatgta                                                   20


<210> 15702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 15702
ttttcactgg ttcttgacca                                                   20


<210> 15703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15703
atatggattt aggttttcac                                                   20


<210> 15704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15704
tattttgtga atatggattt                                                   20


<210> 15705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15705
ctattttgtg aatatggatt                                                   20


<210> 15706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15706
aataagctat tttgtgaata                                                   20


<210> 15707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15707
tcatttgctt atttacaaat                                                   20


<210> 15708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15708
ttattctatt ttgtatctaa                                                   20


<210> 15709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15709
ctaggacccg aagattgaaa                                                   20


<210> 15710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15710
tttacaaaca ctaggacccg                                                   20


<210> 15711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15711
cttgtacctt tacaaacact                                                   20


<210> 15712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15712
acttgtacct ttacaaacac                                                   20


<210> 15713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15713
atagcttcaa aaacaaaagt                                                   20


<210> 15714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15714
catagcttca aaaacaaaag                                                   20


<210> 15715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15715
catcatagct tcaaaaacaa                                                   20


<210> 15716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15716
ttggctggaa gtagtcatca                                                   20


<210> 15717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15717
ccactatcat tggctggaag                                                   20


<210> 15718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15718
gctccactat cattggctgg                                                   20


<210> 15719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15719
tttgctccac tatcattggc                                                   20


<210> 15720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15720
ttgctttgct ccactatcat                                                   20


<210> 15721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15721
tggctcccca gcagaaagta                                                   20


<210> 15722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15722
atggctcccc agcagaaagt                                                   20


<210> 15723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15723
acaaatggct ccccagcaga                                                   20


<210> 15724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15724
aattacaaat ggctccccag                                                   20


<210> 15725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15725
cataattaca aatggctccc                                                   20


<210> 15726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15726
ctcttcctca taattacaaa                                                   20


<210> 15727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15727
acagccagag ccttgtctta                                                   20


<210> 15728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15728
tcacagccag agccttgtct                                                   20


<210> 15729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15729
ggacagaatg ctcacagcca                                                   20


<210> 15730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15730
caggacagaa tgctcacagc                                                   20


<210> 15731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15731
ccgtcaggac agaatgctca                                                   20


<210> 15732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15732
cctaactgcc tccgtcagga                                                   20


<210> 15733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15733
ttgccctaac tgcctccgtc                                                   20


<210> 15734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15734
cttgccctaa ctgcctccgt                                                   20


<210> 15735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15735
ctttccttat ccaccactgt                                                   20


<210> 15736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15736
tcctacttaa tgcaatcatc                                                   20


<210> 15737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15737
ctcctactta atgcaatcat                                                   20


<210> 15738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15738
ttacctcagc tgccacccac                                                   20


<210> 15739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15739
acatcatcag ctcattacct                                                   20


<210> 15740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15740
tactccatga gtgacatcat                                                   20


<210> 15741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15741
tctttcctct aatactccat                                                   20


<210> 15742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15742
tctgtctttc catgacaaat                                                   20


<210> 15743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15743
caacatctcc agaacatccc                                                   20


<210> 15744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15744
cctcttattg ccaacatctc                                                   20


<210> 15745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15745
atcctgaatc atcgctccac                                                   20


<210> 15746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15746
cacccccttt gctcttagtg                                                   20


<210> 15747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15747
gacctcaccc cctttgctct                                                   20


<210> 15748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15748
atattacagc caccaggacc                                                   20


<210> 15749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15749
ccataaatat tacagccacc                                                   20


<210> 15750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15750
cccataaata ttacagccac                                                   20


<210> 15751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15751
cttgtcaccc ataaatatta                                                   20


<210> 15752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15752
tctctttcaa gtctttttgt                                                   20


<210> 15753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15753
ttctctttca agtctttttg                                                   20


<210> 15754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15754
aactctctta gttctctttc                                                   20


<210> 15755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15755
gctgcatgtc ctaactctct                                                   20


<210> 15756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15756
acttcctgct ctgactttgg                                                   20


<210> 15757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15757
ttcacttcct gctctgactt                                                   20


<210> 15758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15758
cacctccaaa ggtaggctct                                                   20


<210> 15759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15759
ggggccccac ctccaaaggt                                                   20


<210> 15760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15760
cggggcccca cctccaaagg                                                   20


<210> 15761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15761
ctccggggcc ccacctccaa                                                   20


<210> 15762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15762
gctccggggc cccacctcca                                                   20


<210> 15763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15763
cccaccaacc ctgagctccg                                                   20


<210> 15764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15764
tcccaccaac cctgagctcc                                                   20


<210> 15765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 15765
atcccaccaa ccctgagctc                                                   20


<210> 15766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15766
ccctccatcc caccaaccct                                                   20


<210> 15767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15767
cttctctggt ctgcaggttt                                                   20


<210> 15768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15768
aaaaaacttc tctggtctgc                                                   20


<210> 15769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15769
caaaaaactt ctctggtctg                                                   20


<210> 15770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15770
aaacaaacaa aaaacttctc                                                   20


<210> 15771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15771
tccagcctgg gtgacagagc                                                   20


<210> 15772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15772
atactccagc ctgggtgaca                                                   20


<210> 15773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15773
ttatactcca gcctgggtga                                                   20


<210> 15774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15774
gtgccattat actccagcct                                                   20


<210> 15775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15775
tgtgccatta tactccagcc                                                   20


<210> 15776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15776
gagattgtgc cattatactc                                                   20


<210> 15777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15777
aggtgtggtg gtagtgagcc                                                   20


<210> 15778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15778
ccacgaggtg tggtggtagt                                                   20


<210> 15779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15779
accaccacga ggtgtggtgg                                                   20


<210> 15780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15780
actaccacca cgaggtgtgg                                                   20


<210> 15781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15781
atcactacca ccacgaggtg                                                   20


<210> 15782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15782
caaaaatcac taccaccacg                                                   20


<210> 15783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15783
acaaaaatca ctaccaccac                                                   20


<210> 15784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15784
cgaaaccctg tctctgctaa                                                   20


<210> 15785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15785
ttaggagttc aaaaccaccc                                                   20


<210> 15786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15786
ggcggatcac ctgaggttag                                                   20


<210> 15787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15787
cgggcggatc acctgaggtt                                                   20


<210> 15788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15788
gcgggcggat cacctgaggt                                                   20


<210> 15789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15789
tgaggcgggc ggatcacctg                                                   20


<210> 15790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15790
ctgaggcggg cggatcacct                                                   20


<210> 15791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 15791
ctttgggagg ctgaggcggg                                                   20


<210> 15792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15792
gcactttggg aggctgaggc                                                   20


<210> 15793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 15793
agcactttgg gaggctgagg                                                   20


<210> 15794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15794
cccagcactt tgggaggctg                                                   20


<210> 15795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15795
tcccagcact ttgggaggct                                                   20


<210> 15796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15796
tgtaatccca gcactttggg                                                   20


<210> 15797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15797
ctgtaatccc agcactttgg                                                   20


<210> 15798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15798
gcctgtaatc ccagcacttt                                                   20


<210> 15799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15799
tgcctgtaat cccagcactt                                                   20


<210> 15800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15800
gtggttcatg cctgtaatcc                                                   20


<210> 15801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15801
tctcatctgg ccaggcacgg                                                   20


<210> 15802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 15802
ttctctcatc tggccaggca                                                   20


<210> 15803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15803
aaaacttctc tcatctggcc                                                   20


<210> 15804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15804
caaaacttct ctcatctggc                                                   20


<210> 15805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15805
atctcaaaac ttctctcatc                                                   20


<210> 15806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15806
cgatttgaag gcatgcgggt                                                   20


<210> 15807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15807
ttctcgattt gaaggcatgc                                                   20


<210> 15808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 15808
tttctcgatt tgaaggcatg                                                   20


<210> 15809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15809
cgggctcttt ctcgatttga                                                   20


<210> 15810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15810
gcgggctctt tctcgatttg                                                   20


<210> 15811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15811
tcgcgctctg cggccactgc                                                   20


<210> 15812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 15812
ttcgcgctct gcggccactg                                                   20


<210> 15813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 15813
ttcgaaccct tcgcgctctg                                                   20


<210> 15814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15814
ttctgaagtg gctcccatca                                                   20


<210> 15815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15815
gattctggaa tattctgaag                                                   20


<210> 15816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15816
gaagattctg gaatattctg                                                   20


<210> 15817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15817
aagtctcaca gcgaagattc                                                   20


<210> 15818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15818
cactgataag tctcacagcg                                                   20


<210> 15819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15819
gatctcactg ataagtctca                                                   20


<210> 15820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15820
tgcactcaga tctcactgat                                                   20


<210> 15821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15821
tttctgccct ctcctgcact                                                   20


<210> 15822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15822
actgcctttc tggaaaccta                                                   20


<210> 15823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15823
ggactgcctt tctggaaacc                                                   20


<210> 15824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15824
ttccacgagg actgcctttc                                                   20


<210> 15825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15825
agttcctgtc tccttccacg                                                   20


<210> 15826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15826
gagttcctgt ctccttccac                                                   20


<210> 15827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15827
ggaatgggag gctgggcagg                                                   20


<210> 15828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15828
taggaatggg aggctgggca                                                   20


<210> 15829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15829
gtaggaatgg gaggctgggc                                                   20


<210> 15830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15830
tgtaggaatg ggaggctggg                                                   20


<210> 15831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15831
acgtgtagga atgggaggct                                                   20


<210> 15832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15832
gacgtgtagg aatgggaggc                                                   20


<210> 15833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15833
cttagacgtg taggaatggg                                                   20


<210> 15834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15834
gcttagacgt gtaggaatgg                                                   20


<210> 15835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15835
tggcttagac gtgtaggaat                                                   20


<210> 15836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15836
atggcttaga cgtgtaggaa                                                   20


<210> 15837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15837
ggatgatggc ttagacgtgt                                                   20


<210> 15838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15838
aggatgatgg cttagacgtg                                                   20


<210> 15839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15839
tgggagctag gatgatggct                                                   20


<210> 15840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15840
taaggtggga gctaggatga                                                   20


<210> 15841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15841
ttccgaataa ggtgggagct                                                   20


<210> 15842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15842
gttccgaata aggtgggagc                                                   20


<210> 15843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15843
tggagttccg aataaggtgg                                                   20


<210> 15844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15844
attggagttc cgaataaggt                                                   20


<210> 15845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15845
cattggagtt ccgaataagg                                                   20


<210> 15846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15846
tctcattgga gttccgaata                                                   20


<210> 15847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15847
ctctcattgg agttccgaat                                                   20


<210> 15848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15848
tctttctaga cctctcattg                                                   20


<210> 15849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15849
actctttcta gacctctcat                                                   20


<210> 15850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15850
ggaagagaca aaactctttc                                                   20


<210> 15851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15851
aaatttttaa taaaagggaa                                                   20


<210> 15852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15852
taaaattttt aataaaaggg                                                   20


<210> 15853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15853
gaataaaatt tttaataaaa                                                   20


<210> 15854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15854
tgaataaaat ttttaataaa                                                   20


<210> 15855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15855
gtgaataaaa tttttaataa                                                   20


<210> 15856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15856
gcccagattg tttaagagag                                                   20


<210> 15857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15857
cttgcccaga ttgtttaaga                                                   20


<210> 15858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15858
ttcttgccca gattgtttaa                                                   20


<210> 15859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15859
ttttcttgcc cagattgttt                                                   20


<210> 15860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15860
gagactgagt ttttcttgcc                                                   20


<210> 15861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15861
ggttggtgat gttagagact                                                   20


<210> 15862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15862
accagaggtt ggtgatgtta                                                   20


<210> 15863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15863
gtaccagagg ttggtgatgt                                                   20


<210> 15864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15864
gccacctacg taccagaggt                                                   20


<210> 15865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15865
cttggccacc tacgtaccag                                                   20


<210> 15866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15866
gcttggccac ctacgtacca                                                   20


<210> 15867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15867
aagcttggcc acctacgtac                                                   20


<210> 15868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15868
gatttaatac actggaagct                                                   20


<210> 15869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15869
gagttgattt aatacactgg                                                   20


<210> 15870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15870
gaagagttga tttaatacac                                                   20


<210> 15871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15871
gcccctagaa ggaaaaggaa                                                   20


<210> 15872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15872
ctgcccctag aaggaaaagg                                                   20


<210> 15873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15873
ctgctgcccc tagaaggaaa                                                   20


<210> 15874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15874
actgctgccc ctagaaggaa                                                   20


<210> 15875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15875
gcctgactgc tgcccctaga                                                   20


<210> 15876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15876
ggcctgactg ctgcccctag                                                   20


<210> 15877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15877
tgaggcctga ctgctgcccc                                                   20


<210> 15878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15878
aatcagtttc aaggttgttg                                                   20


<210> 15879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15879
aaatcagttt caaggttgtt                                                   20


<210> 15880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15880
gtctctgaaa atcagtttca                                                   20


<210> 15881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15881
agtctctgaa aatcagtttc                                                   20


<210> 15882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15882
gtctccaagt ctctgaaaat                                                   20


<210> 15883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15883
ggagggaaca tcatgtctcc                                                   20


<210> 15884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15884
tctcagcata gcccctagga                                                   20


<210> 15885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15885
ctctcagcat agcccctagg                                                   20


<210> 15886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15886
actctcagca tagcccctag                                                   20


<210> 15887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15887
agactctcag catagcccct                                                   20


<210> 15888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15888
tagactctca gcatagcccc                                                   20


<210> 15889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15889
ctcagaatag actctcagca                                                   20


<210> 15890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15890
tattcctcag aatagactct                                                   20


<210> 15891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15891
gattactata ttcctcagaa                                                   20


<210> 15892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15892
attcagatta ctatattcct                                                   20


<210> 15893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15893
ttctctgagc aaatataatt                                                   20


<210> 15894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15894
tctttccacc ccacttctct                                                   20


<210> 15895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15895
atcagggttc aaatgggaat                                                   20


<210> 15896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15896
caaaaaatca gggttcaaat                                                   20


<210> 15897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15897
acaaaaaatc agggttcaaa                                                   20


<210> 15898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15898
cccaagctca caaaaaatca                                                   20


<210> 15899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15899
acccaagctc acaaaaaatc                                                   20


<210> 15900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15900
aacccaagct cacaaaaaat                                                   20


<210> 15901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15901
gactagccag gcactaaccc                                                   20


<210> 15902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15902
gaaagtaccc tggactagcc                                                   20


<210> 15903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15903
tgaaagtacc ctggactagc                                                   20


<210> 15904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15904
agggtgaaag taccctggac                                                   20


<210> 15905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15905
tacaaagggt gaaagtaccc                                                   20


<210> 15906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15906
tttcatttta caaagggtga                                                   20


<210> 15907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15907
tgactttttc attttacaaa                                                   20


<210> 15908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15908
ctgacttttt cattttacaa                                                   20


<210> 15909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15909
tctgactttt tcattttaca                                                   20


<210> 15910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15910
tcagaacttt ggaattctct                                                   20


<210> 15911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15911
ctgcagagct atcagaactt                                                   20


<210> 15912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15912
ttgaagaact gcagagctat                                                   20


<210> 15913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15913
aaactttttg aagaactgca                                                   20


<210> 15914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15914
agaaactttt tgaagaactg                                                   20


<210> 15915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15915
cccataccag aaactttttg                                                   20


<210> 15916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15916
tagatctcat ggacccatac                                                   20


<210> 15917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15917
tctattgaag ctagatctca                                                   20


<210> 15918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15918
tctcagatat ctattgaagc                                                   20


<210> 15919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15919
tatatctcag atatctattg                                                   20


<210> 15920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15920
acaagtcagt cattatatct                                                   20


<210> 15921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15921
accaaaaggg gctcacaagt                                                   20


<210> 15922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15922
acagaccaaa aggggctcac                                                   20


<210> 15923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15923
gaaaactgac agaccaaaag                                                   20


<210> 15924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15924
agaaaactga cagaccaaaa                                                   20


<210> 15925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15925
aagaaaactg acagaccaaa                                                   20


<210> 15926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15926
aaagaaaact gacagaccaa                                                   20


<210> 15927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15927
caccacttaa agaaaactga                                                   20


<210> 15928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15928
agtctttgga ccaccactta                                                   20


<210> 15929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15929
tttctgtcct ttgcagtctt                                                   20


<210> 15930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15930
atgtaagttt ctgtcctttg                                                   20


<210> 15931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15931
caggggaact tttttcatgt                                                   20


<210> 15932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15932
accttcaaag ttcctagcag                                                   20


<210> 15933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15933
caccttcaaa gttcctagca                                                   20


<210> 15934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15934
gcaccttcaa agttcctagc                                                   20


<210> 15935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15935
ggcaccttca aagttcctag                                                   20


<210> 15936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15936
cctggcacct tcaaagttcc                                                   20


<210> 15937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15937
acatctccct ggcaccttca                                                   20


<210> 15938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15938
ccgtatctat gacatctccc                                                   20


<210> 15939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15939
gatctcacag gacagggtca                                                   20


<210> 15940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15940
ggctaagatc tcacaggaca                                                   20


<210> 15941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15941
tggctaagat ctcacaggac                                                   20


<210> 15942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15942
gtggctaaga tctcacagga                                                   20


<210> 15943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15943
tggtgtggct aagatctcac                                                   20


<210> 15944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15944
gtggtgtggc taagatctca                                                   20


<210> 15945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15945
ccaccatctg tggtgtggct                                                   20


<210> 15946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15946
tcagcccacc atctgtggtg                                                   20


<210> 15947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15947
tgaattcagc ccaccatctg                                                   20


<210> 15948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15948
ggataagctg agcctgaatt                                                   20


<210> 15949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15949
cctaactgcc aggataagct                                                   20


<210> 15950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15950
tcccacctaa ctgccaggat                                                   20


<210> 15951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15951
gtgcatccca cctaactgcc                                                   20


<210> 15952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15952
tgtgcatccc acctaactgc                                                   20


<210> 15953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15953
tataaagccc ttcttttctg                                                   20


<210> 15954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15954
ggctctgcca ctcaagtata                                                   20


<210> 15955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15955
tgcttggggc tctgccactc                                                   20


<210> 15956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15956
caaagaatgg acattgcttg                                                   20


<210> 15957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15957
ccaaagaatg gacattgctt                                                   20


<210> 15958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15958
tccaaagaat ggacattgct                                                   20


<210> 15959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15959
taagccactc atccaaagaa                                                   20


<210> 15960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15960
tgcaataagc cactcatcca                                                   20


<210> 15961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15961
gttctttgtc ctggtgcaat                                                   20


<210> 15962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15962
tccattccgg ttctttgtcc                                                   20


<210> 15963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 15963
gaagagggtc ccttccattc                                                   20


<210> 15964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15964
cttgcatgaa tgaaggaaga                                                   20


<210> 15965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15965
ccttgcatga atgaaggaag                                                   20


<210> 15966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15966
gccttgcatg aatgaaggaa                                                   20


<210> 15967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15967
gagccttgca tgaatgaagg                                                   20


<210> 15968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15968
ctggagcctt gcatgaatga                                                   20


<210> 15969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15969
tctggagcct tgcatgaatg                                                   20


<210> 15970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15970
gtctcacctg ctgatgtctg                                                   20


<210> 15971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15971
gggtctcacc tgctgatgtc                                                   20


<210> 15972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15972
cctcatgcac ccaggcagct                                                   20


<210> 15973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15973
ccctcatgca cccaggcagc                                                   20


<210> 15974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15974
cctaccctca tgcacccagg                                                   20


<210> 15975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15975
ctccctaccc tcatgcaccc                                                   20


<210> 15976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15976
cctccctacc ctcatgcacc                                                   20


<210> 15977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15977
aatagggttc agcatggaac                                                   20


<210> 15978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15978
agactgaata gggttcagca                                                   20


<210> 15979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15979
gcaaaagact gaatagggtt                                                   20


<210> 15980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15980
gctgagcaaa agactgaata                                                   20


<210> 15981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15981
ggctgagcaa aagactgaat                                                   20


<210> 15982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 15982
gggctgagca aaagactgaa                                                   20


<210> 15983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 15983
cttcccaggg ggctgagcaa                                                   20


<210> 15984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15984
ggcagacttc ccagggggct                                                   20


<210> 15985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15985
tgtgaggcag acttcccagg                                                   20


<210> 15986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15986
atgtgaggca gacttcccag                                                   20


<210> 15987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 15987
catgtgaggc agacttccca                                                   20


<210> 15988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15988
ccatgtgagg cagacttccc                                                   20


<210> 15989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15989
tccatgtgag gcagacttcc                                                   20


<210> 15990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15990
tgcagattat ccatgtgagg                                                   20


<210> 15991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15991
agctgcagat tatccatgtg                                                   20


<210> 15992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15992
cagctgcaga ttatccatgt                                                   20


<210> 15993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15993
gcacctgtct gccccagctg                                                   20


<210> 15994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15994
ggcacagcac ctgtctgccc                                                   20


<210> 15995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 15995
cagactttgc tggagaggca                                                   20


<210> 15996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 15996
gtggacagac tttgctggag                                                   20


<210> 15997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15997
ggtggacaga ctttgctgga                                                   20


<210> 15998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 15998
tgggtggaca gactttgctg                                                   20


<210> 15999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 15999
cttgggtgga cagactttgc                                                   20


<210> 16000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16000
tggaggtggg cttgggtgga                                                   20


<210> 16001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16001
ggaatggagg tgggcttggg                                                   20


<210> 16002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16002
gtgggaatgg aggtgggctt                                                   20


<210> 16003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16003
agtgggaatg gaggtgggct                                                   20


<210> 16004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16004
tgagcagtgg gaatggaggt                                                   20


<210> 16005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16005
ctgagcagtg ggaatggagg                                                   20


<210> 16006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16006
gggctgagca gtgggaatgg                                                   20


<210> 16007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16007
tgggctgagc agtgggaatg                                                   20


<210> 16008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16008
agtgggctga gcagtgggaa                                                   20


<210> 16009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16009
aggctagtgg gctgagcagt                                                   20


<210> 16010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16010
gaggctagtg ggctgagcag                                                   20


<210> 16011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16011
tgggaggcta gtgggctgag                                                   20


<210> 16012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16012
acttgggagg ctagtgggct                                                   20


<210> 16013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16013
agactacttg ggaggctagt                                                   20


<210> 16014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16014
gagactactt gggaggctag                                                   20


<210> 16015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16015
ctggagacta cttgggaggc                                                   20


<210> 16016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16016
gggcctggag actacttggg                                                   20


<210> 16017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16017
agggcctgga gactacttgg                                                   20


<210> 16018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16018
ctagggcctg gagactactt                                                   20


<210> 16019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16019
actagggcct ggagactact                                                   20


<210> 16020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16020
tggtgcagta ctagggcctg                                                   20


<210> 16021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16021
catggtgcag tactagggcc                                                   20


<210> 16022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16022
agatgcatgg tgcagtacta                                                   20


<210> 16023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16023
tagatgcatg gtgcagtact                                                   20


<210> 16024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16024
atagatgcat ggtgcagtac                                                   20


<210> 16025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16025
tggagaatag atgcatggtg                                                   20


<210> 16026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16026
tgcagtggag aatagatgca                                                   20


<210> 16027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16027
atcagatttg cagtggagaa                                                   20


<210> 16028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16028
tcataatcag atttgcagtg                                                   20


<210> 16029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16029
gatcataatc agatttgcag                                                   20


<210> 16030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16030
catgatcata atcagatttg                                                   20


<210> 16031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16031
gagaaagaca tgatcataat                                                   20


<210> 16032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16032
tgatgtttgg gagtaagaga                                                   20


<210> 16033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16033
ccagtgatgt ttgggagtaa                                                   20


<210> 16034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16034
taccagtgat gtttgggagt                                                   20


<210> 16035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16035
aaagtaccag tgatgtttgg                                                   20


<210> 16036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16036
ataaagtacc agtgatgttt                                                   20


<210> 16037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16037
gataaagtac cagtgatgtt                                                   20


<210> 16038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16038
tcctgagggt gataaagtac                                                   20


<210> 16039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16039
agtttatcct gagggtgata                                                   20


<210> 16040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16040
gagtatggag tttatcctga                                                   20


<210> 16041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16041
agagtatgga gtttatcctg                                                   20


<210> 16042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16042
cagagtatgg agtttatcct                                                   20


<210> 16043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16043
gacacaggct acagagtatg                                                   20


<210> 16044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16044
atgacacagg ctacagagta                                                   20


<210> 16045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16045
accatatgac acaggctaca                                                   20


<210> 16046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16046
tgaccatatg acacaggcta                                                   20


<210> 16047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16047
aggttgtgac catatgacac                                                   20


<210> 16048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16048
taggttgtga ccatatgaca                                                   20


<210> 16049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16049
tgaaatatga ctggaaaagt                                                   20


<210> 16050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16050
gtgaaatatg actggaaaag                                                   20


<210> 16051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16051
tgggtgaaat atgactggaa                                                   20


<210> 16052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16052
atgtgtgggt gaaatatgac                                                   20


<210> 16053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16053
ttgatttggg tagaatgtgt                                                   20


<210> 16054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16054
tttgatttgg gtagaatgtg                                                   20


<210> 16055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16055
agggaacaat ttgatttggg                                                   20


<210> 16056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16056
ctcagggaac aatttgattt                                                   20


<210> 16057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16057
gctcagggaa caatttgatt                                                   20


<210> 16058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16058
cacagacaca agtatgctca                                                   20


<210> 16059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16059
gcacagacac aagtatgctc                                                   20


<210> 16060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16060
ggcacagaca caagtatgct                                                   20


<210> 16061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16061
ttgaacaaag gcacagacac                                                   20


<210> 16062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16062
gctgaccttg aacaaaggca                                                   20


<210> 16063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16063
taaaggctga ccttgaacaa                                                   20


<210> 16064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16064
ctaaaggctg accttgaaca                                                   20


<210> 16065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16065
ggaaggcccg tcttagctaa                                                   20


<210> 16066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16066
gggaaggccc gtcttagcta                                                   20


<210> 16067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16067
ggactgggga aggcccgtct                                                   20


<210> 16068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16068
agctgcgaga ggactgggga                                                   20


<210> 16069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16069
gagctgcgag aggactgggg                                                   20


<210> 16070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16070
aaggagctgc gagaggactg                                                   20


<210> 16071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16071
caaggagctg cgagaggact                                                   20


<210> 16072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16072
ccaaggagct gcgagaggac                                                   20


<210> 16073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16073
caggaccaag gagctgcgag                                                   20


<210> 16074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16074
gcaggaccaa ggagctgcga                                                   20


<210> 16075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16075
gagcaggacc aaggagctgc                                                   20


<210> 16076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16076
tagaaatgag caggaccaag                                                   20


<210> 16077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16077
catagaaatg agcaggacca                                                   20


<210> 16078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16078
gcatagaaat gagcaggacc                                                   20


<210> 16079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16079
tgtggggcat agaaatgagc                                                   20


<210> 16080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16080
atgtggggca tagaaatgag                                                   20


<210> 16081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16081
tagatgtggg gcatagaaat                                                   20


<210> 16082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16082
gtggcattag atgtggggca                                                   20


<210> 16083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16083
gggaggtggc attagatgtg                                                   20


<210> 16084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16084
tgggaggtgg cattagatgt                                                   20


<210> 16085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16085
atgggaggtg gcattagatg                                                   20


<210> 16086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16086
cttcctatgg gaggtggcat                                                   20


<210> 16087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16087
agaattcttc ctatgggagg                                                   20


<210> 16088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16088
ttgagaattc ttcctatggg                                                   20


<210> 16089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16089
gttgagaatt cttcctatgg                                                   20


<210> 16090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16090
tggttgagaa ttcttcctat                                                   20


<210> 16091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16091
gtggttgaga attcttccta                                                   20


<210> 16092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16092
actcttgggg tggggtggtt                                                   20


<210> 16093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16093
cttccactct tggggtgggg                                                   20


<210> 16094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16094
cttcttccac tcttggggtg                                                   20


<210> 16095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16095
ccttcttcca ctcttggggt                                                   20


<210> 16096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16096
gccttcttcc actcttgggg                                                   20


<210> 16097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16097
tgagccttct tccactcttg                                                   20


<210> 16098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16098
atgagccttc ttccactctt                                                   20


<210> 16099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16099
catgagcctt cttccactct                                                   20


<210> 16100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16100
tcttggagac acagagacat                                                   20


<210> 16101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16101
attagtatct tggagacaca                                                   20


<210> 16102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16102
caattagtat cttggagaca                                                   20


<210> 16103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16103
tgggggcaat tagtatcttg                                                   20


<210> 16104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16104
gctgggggca attagtatct                                                   20


<210> 16105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16105
tgagcactgc tgggggcaat                                                   20


<210> 16106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16106
aatgtgttga gcactgctgg                                                   20


<210> 16107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16107
gaatgtgttg agcactgctg                                                   20


<210> 16108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16108
tgaatgtgtt gagcactgct                                                   20


<210> 16109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16109
gtgaatgtgt tgagcactgc                                                   20


<210> 16110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16110
attataaggg tgaatgtgtt                                                   20


<210> 16111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16111
tggaaataaa tgtattataa                                                   20


<210> 16112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16112
atggaaataa atgtattata                                                   20


<210> 16113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16113
catggaaata aatgtattat                                                   20


<210> 16114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16114
ttcagcagac aagacacaca                                                   20


<210> 16115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16115
actttagtct ttcagcagac                                                   20


<210> 16116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16116
cttacacttt agtctttcag                                                   20


<210> 16117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16117
gatcttacac tttagtcttt                                                   20


<210> 16118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16118
atctccagga tcttacactt                                                   20


<210> 16119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16119
aataaatact cactatctcc                                                   20


<210> 16120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16120
gaataaatac tcactatctc                                                   20


<210> 16121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16121
ctttgtaaga aacagaagca                                                   20


<210> 16122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16122
aagtgctttg taagaaacag                                                   20


<210> 16123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16123
atgaagtgct ttgtaagaaa                                                   20


<210> 16124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16124
tgtcttatga agtgctttgt                                                   20


<210> 16125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16125
gaatacagga ttgtcttatg                                                   20


<210> 16126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16126
tacatctaac tattgaatac                                                   20


<210> 16127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16127
atacatctaa ctattgaata                                                   20


<210> 16128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16128
cttctttctt tctttccttc                                                   20


<210> 16129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16129
tcacccttca acttttcatc                                                   20


<210> 16130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16130
caatatgcta ttattaacta                                                   20


<210> 16131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16131
agcagctata attactcagc                                                   20


<210> 16132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16132
caagagcagc tataattact                                                   20


<210> 16133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16133
ttctccccct gtggcaagag                                                   20


<210> 16134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16134
catttctccc cctgtggcaa                                                   20


<210> 16135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16135
cccatttctc cccctgtggc                                                   20


<210> 16136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16136
gttacccatt tctccccctg                                                   20


<210> 16137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16137
aacatatcca tcatctcaca                                                   20


<210> 16138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16138
tatataaatg attactatag                                                   20


<210> 16139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16139
atatatataa atgattacta                                                   20


<210> 16140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16140
gggatacaaa atgatgttat                                                   20


<210> 16141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16141
caaaccatat caatttttaa                                                   20


<210> 16142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16142
ccaaaccata tcaattttta                                                   20


<210> 16143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16143
gccaaaccat atcaattttt                                                   20


<210> 16144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16144
ataagatttg ggtggggaca                                                   20


<210> 16145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16145
ttcaagataa gatttgggtg                                                   20


<210> 16146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16146
attcaagata agatttgggt                                                   20


<210> 16147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16147
aattcaagat aagatttggg                                                   20


<210> 16148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16148
gggaattcaa gataagattt                                                   20


<210> 16149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16149
tgggaattca agataagatt                                                   20


<210> 16150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16150
aacacatggg aattcaagat                                                   20


<210> 16151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16151
cccacaacac atgggaattc                                                   20


<210> 16152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16152
cctcccctcc cacaacacat                                                   20


<210> 16153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16153
ccctcccctc ccacaacaca                                                   20


<210> 16154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16154
tgattcactt acctcccaca                                                   20


<210> 16155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16155
atgattcact tacctcccac                                                   20


<210> 16156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16156
catgattcac ttacctccca                                                   20


<210> 16157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16157
atcatgagaa cagcatggga                                                   20


<210> 16158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16158
cactatcatg agaacagcat                                                   20


<210> 16159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16159
tcactatcat gagaacagca                                                   20


<210> 16160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16160
cttattcact atcatgagaa                                                   20


<210> 16161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16161
tgaaacttat tcactatcat                                                   20


<210> 16162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16162
gcaaagagag aggttgggca                                                   20


<210> 16163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16163
ggcaaagaga gaggttgggc                                                   20


<210> 16164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16164
aggcaaagag agaggttggg                                                   20


<210> 16165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16165
agcaggcaaa gagagaggtt                                                   20


<210> 16166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16166
cagcaggcaa agagagaggt                                                   20


<210> 16167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16167
atggcagcag gcaaagagag                                                   20


<210> 16168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16168
gatggcagca ggcaaagaga                                                   20


<210> 16169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16169
tggatggcag caggcaaaga                                                   20


<210> 16170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16170
tgtggatggc agcaggcaaa                                                   20


<210> 16171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16171
tatgtggatg gcagcaggca                                                   20


<210> 16172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16172
cgtcttatgt ggatggcagc                                                   20


<210> 16173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16173
acgtcttatg tggatggcag                                                   20


<210> 16174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16174
gtcacgtctt atgtggatgg                                                   20


<210> 16175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16175
cgagtcacgt cttatgtgga                                                   20


<210> 16176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16176
ggtgcgagtc acgtcttatg                                                   20


<210> 16177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16177
ggcaaaagga aaggaggtgc                                                   20


<210> 16178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16178
aatcatggca aaaggaaagg                                                   20


<210> 16179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16179
caatcatggc aaaaggaaag                                                   20


<210> 16180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16180
tacaatcatg gcaaaaggaa                                                   20


<210> 16181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16181
ttacaatcat ggcaaaagga                                                   20


<210> 16182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16182
agccttacaa tcatggcaaa                                                   20


<210> 16183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16183
aagccttaca atcatggcaa                                                   20


<210> 16184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16184
ctggggaagc cttacaatca                                                   20


<210> 16185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16185
acagcttcac atggctgggg                                                   20


<210> 16186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16186
cttacagctt cacatggctg                                                   20


<210> 16187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16187
acttacagct tcacatggct                                                   20


<210> 16188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16188
gacttacagc ttcacatggc                                                   20


<210> 16189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16189
attggactta cagcttcaca                                                   20


<210> 16190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16190
aagaggttta attggactta                                                   20


<210> 16191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16191
ataaaagaaa gaggtttaat                                                   20


<210> 16192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16192
gggcaattta taaaagaaag                                                   20


<210> 16193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16193
tgggcaattt ataaaagaaa                                                   20


<210> 16194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16194
actgggcaat ttataaaaga                                                   20


<210> 16195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16195
taagactggg caatttataa                                                   20


<210> 16196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16196
ataaagacat acctaagact                                                   20


<210> 16197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16197
gataaagaca tacctaagac                                                   20


<210> 16198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16198
ctgctgataa agacatacct                                                   20


<210> 16199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16199
ctattttcat gctgctgata                                                   20


<210> 16200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16200
tttattgtat atatttgtat                                                   20


<210> 16201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16201
catgcattag tcattttacc                                                   20


<210> 16202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16202
ccatctttcc attcatgcat                                                   20


<210> 16203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16203
ttccattcat ctattctgtc                                                   20


<210> 16204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16204
catccatcct atcaaccttc                                                   20


<210> 16205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16205
cattcacgca tcttccatcc                                                   20


<210> 16206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16206
ttccagctgt acatcttcat                                                   20


<210> 16207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16207
ccatccatct ttatttcttc                                                   20


<210> 16208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16208
accttttgta tccaaccatt                                                   20


<210> 16209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16209
tcagtcctaa tcaccttaaa                                                   20


<210> 16210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16210
tatgttgatc tcaccagtct                                                   20


<210> 16211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16211
cctgcttatg ttgatctcac                                                   20


<210> 16212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16212
gtcccacccc tttgggggca                                                   20


<210> 16213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16213
ccggtgtccc acccctttgg                                                   20


<210> 16214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16214
tccggtgtcc cacccctttg                                                   20


<210> 16215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16215
ttccggtgtc ccaccccttt                                                   20


<210> 16216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16216
attccggtgt cccacccctt                                                   20


<210> 16217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16217
gaaaggaaaa ttatttattc                                                   20


<210> 16218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16218
aataattatt cataaatgaa                                                   20


<210> 16219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16219
aaataattat tcataaatga                                                   20


<210> 16220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16220
aggcctgaaa tctgagtcat                                                   20


<210> 16221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16221
gaggcctgaa atctgagtca                                                   20


<210> 16222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16222
agctgtgagg cctgaaatct                                                   20


<210> 16223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16223
taccacaagg attagctgtg                                                   20


<210> 16224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16224
gtaccacaag gattagctgt                                                   20


<210> 16225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16225
ggccactgta ccacaaggat                                                   20


<210> 16226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16226
cttcaggcca ctgtaccaca                                                   20


<210> 16227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16227
gcttcaggcc actgtaccac                                                   20


<210> 16228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16228
gccaatgcac tagcagcttc                                                   20


<210> 16229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16229
tgccaatgca ctagcagctt                                                   20


<210> 16230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16230
ccctgatgcc aatgcactag                                                   20


<210> 16231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16231
cttccctgat gccaatgcac                                                   20


<210> 16232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16232
gctggcaggt cctccatagc                                                   20


<210> 16233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16233
tgctggcagg tcctccatag                                                   20


<210> 16234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16234
ctgtgctggc aggtcctcca                                                   20


<210> 16235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16235
gtccagcctc ctgtgctggc                                                   20


<210> 16236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16236
tgtccagcct cctgtgctgg                                                   20


<210> 16237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16237
ttctgtccag cctcctgtgc                                                   20


<210> 16238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16238
tcagcacaga acattctgtc                                                   20


<210> 16239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16239
aagctggatg aggttcagca                                                   20


<210> 16240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16240
tcctgaagct ggatgaggtt                                                   20


<210> 16241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16241
ttgcctcctg aagctggatg                                                   20


<210> 16242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16242
cttgcctcct gaagctggat                                                   20


<210> 16243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16243
tggtgcttgc ctcctgaagc                                                   20


<210> 16244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16244
tatttggtgc ttgcctcctg                                                   20


<210> 16245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16245
tcaggaaatg tgtctgtatt                                                   20


<210> 16246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16246
gtctgcccag cagaggtgtc                                                   20


<210> 16247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16247
ggtctgccca gcagaggtgt                                                   20


<210> 16248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16248
cagcaaggtc tgcccagcag                                                   20


<210> 16249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16249
gcagcaaggt ctgcccagca                                                   20


<210> 16250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16250
cagcagcaag gtctgcccag                                                   20


<210> 16251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16251
tgccagcagc aaggtctgcc                                                   20


<210> 16252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16252
tcaagcagct gccagcagca                                                   20


<210> 16253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16253
ctcaagcagc tgccagcagc                                                   20


<210> 16254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16254
cccactcaag cagctgccag                                                   20


<210> 16255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16255
tgccccactc aagcagctgc                                                   20


<210> 16256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16256
ctctgcctgc cccactcaag                                                   20


<210> 16257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16257
ggtctctgcc tgccccactc                                                   20


<210> 16258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16258
gggtgaggca tgtgctgtgt                                                   20


<210> 16259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16259
gggtttctgc aagcagggtg                                                   20


<210> 16260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16260
agggtttctg caagcagggt                                                   20


<210> 16261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16261
gctgagggtt tctgcaagca                                                   20


<210> 16262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16262
agctgagggt ttctgcaagc                                                   20


<210> 16263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16263
tagctgaggg tttctgcaag                                                   20


<210> 16264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16264
gcatagctga gggtttctgc                                                   20


<210> 16265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16265
gttcactgcc gcatagctga                                                   20


<210> 16266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16266
tgttcactgc cgcatagctg                                                   20


<210> 16267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16267
ctgttcactg ccgcatagct                                                   20


<210> 16268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16268
gttatctgtt cactgccgca                                                   20


<210> 16269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16269
gctttgcagc atggttaact                                                   20


<210> 16270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16270
accttctttg ctttgcagca                                                   20


<210> 16271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16271
ccactacctt ctttgctttg                                                   20


<210> 16272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16272
acattgcact atcactgtct                                                   20


<210> 16273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16273
cacattgcac tatcactgtc                                                   20


<210> 16274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16274
acatcagaca tgtgattcct                                                   20


<210> 16275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16275
actgtgtgct tctcacacat                                                   20


<210> 16276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16276
ggccagtaat ccctgcatta                                                   20


<210> 16277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16277
gtggccagta atccctgcat                                                   20


<210> 16278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16278
cactcatggt aacctgtggc                                                   20


<210> 16279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16279
ttcacactca tggtaacctg                                                   20


<210> 16280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16280
agttcatgtg ttcacactca                                                   20


<210> 16281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16281
tttggagagg taatgagctg                                                   20


<210> 16282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16282
catttggaga ggtaatgagc                                                   20


<210> 16283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16283
ggcgcatttg gagaggtaat                                                   20


<210> 16284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16284
aacagagggc gcatttggag                                                   20


<210> 16285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16285
gaacagaggg cgcatttgga                                                   20


<210> 16286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16286
aagaacagag ggcgcatttg                                                   20


<210> 16287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16287
aaaagaacag agggcgcatt                                                   20


<210> 16288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16288
gtggcattga aaagaacaga                                                   20


<210> 16289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16289
agtggcattg aaaagaacag                                                   20


<210> 16290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16290
cagtggcatt gaaaagaaca                                                   20


<210> 16291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16291
cccagtggca ttgaaaagaa                                                   20


<210> 16292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16292
tcctccccag tggcattgaa                                                   20


<210> 16293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16293
tactgctgcc tcctccccag                                                   20


<210> 16294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16294
ttatactgct gcctcctccc                                                   20


<210> 16295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16295
agccatggct tagaaccact                                                   20


<210> 16296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16296
tccaaggtgc agccatggct                                                   20


<210> 16297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16297
gcatttccaa ggtgcagcca                                                   20


<210> 16298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16298
tcccaggcat ttccaaggtg                                                   20


<210> 16299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16299
aatgctccca ggcatttcca                                                   20


<210> 16300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16300
aaatgctccc aggcatttcc                                                   20


<210> 16301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16301
tgtattttat aaatgctccc                                                   20


<210> 16302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16302
ctgtatttta taaatgctcc                                                   20


<210> 16303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16303
attggtcttg ggtggtgccc                                                   20


<210> 16304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16304
tattggtctt gggtggtgcc                                                   20


<210> 16305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16305
ctgatcttat tggtcttggg                                                   20


<210> 16306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16306
attctgatct tattggtctt                                                   20


<210> 16307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16307
gattctgatc ttattggtct                                                   20


<210> 16308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16308
cccagagatt ctgatcttat                                                   20


<210> 16309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16309
gaccgaccac cactacccca                                                   20


<210> 16310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16310
gtgaccgacc accactaccc                                                   20


<210> 16311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16311
ctggggagct atgaaatatg                                                   20


<210> 16312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16312
gcacttgaga atcacctggg                                                   20


<210> 16313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16313
ctgcacttga gaatcacctg                                                   20


<210> 16314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16314
gctgcacttg agaatcacct                                                   20


<210> 16315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16315
ggctgcactt gagaatcacc                                                   20


<210> 16316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16316
cctcacacct ggctgcactt                                                   20


<210> 16317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16317
ggttctgtgg tcctcacacc                                                   20


<210> 16318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16318
tcttcccacc tgcggttctg                                                   20


<210> 16319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16319
acagagaatc ttcccacctg                                                   20


<210> 16320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16320
agccatgaac tgtgagcaca                                                   20


<210> 16321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16321
ggagccatga actgtgagca                                                   20


<210> 16322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16322
cttggggagc catgaactgt                                                   20


<210> 16323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16323
tgggtcttct ggaccttggg                                                   20


<210> 16324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16324
gatgggtctt ctggaccttg                                                   20


<210> 16325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16325
agatgggtct tctggacctt                                                   20


<210> 16326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16326
tagatgggtc ttctggacct                                                   20


<210> 16327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16327
gcatccatag atgggtcttc                                                   20


<210> 16328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16328
atggccctgc atccatagat                                                   20


<210> 16329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16329
tatggccctg catccataga                                                   20


<210> 16330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16330
gtcttatggc cctgcatcca                                                   20


<210> 16331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16331
tgcagctctc agaggtctta                                                   20


<210> 16332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16332
atgacacatg cagctctcag                                                   20


<210> 16333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16333
gatgacacat gcagctctca                                                   20


<210> 16334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16334
gagatgacac atgcagctct                                                   20


<210> 16335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16335
ccaaagtgag atgacacatg                                                   20


<210> 16336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16336
tgcattttta catccaaagt                                                   20


<210> 16337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16337
cctctgcatt tttacatcca                                                   20


<210> 16338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16338
ttattaggtc tccattcaga                                                   20


<210> 16339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16339
tgagttatta ggtctccatt                                                   20


<210> 16340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16340
tgactgttag gtgagttatt                                                   20


<210> 16341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16341
gtgactgtta ggtgagttat                                                   20


<210> 16342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16342
cacaatagtg actgttaggt                                                   20


<210> 16343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16343
gtgacacaat agtgactgtt                                                   20


<210> 16344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16344
tgtgacacaa tagtgactgt                                                   20


<210> 16345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16345
agtatgtgac tgtgacacaa                                                   20


<210> 16346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16346
catgagtggt aaagtccagg                                                   20


<210> 16347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16347
acccatgagt ggtaaagtcc                                                   20


<210> 16348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16348
cacccatgag tggtaaagtc                                                   20


<210> 16349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16349
cctgacaccc atgagtggta                                                   20


<210> 16350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16350
atagccctga cacccatgag                                                   20


<210> 16351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16351
agaatagccc tgacacccat                                                   20


<210> 16352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16352
tttagtgagg agtctgagaa                                                   20


<210> 16353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16353
gagcatttag tgaggagtct                                                   20


<210> 16354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16354
agttttgagc atttagtgag                                                   20


<210> 16355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16355
aaagttttga gcatttagtg                                                   20


<210> 16356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16356
aaaagttttg agcatttagt                                                   20


<210> 16357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16357
aaagaaaagt tttgagcatt                                                   20


<210> 16358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16358
ctactccaaa gaaaagtttt                                                   20


<210> 16359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16359
tcaagggcta ctccaaagaa                                                   20


<210> 16360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16360
ggccctcaag ggctactcca                                                   20


<210> 16361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16361
ctcagagacc tggccctcaa                                                   20


<210> 16362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16362
gctcagagac ctggccctca                                                   20


<210> 16363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16363
agctcagaga cctggccctc                                                   20


<210> 16364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16364
gcaaaggaag ctcagagacc                                                   20


<210> 16365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16365
gctagggcaa aggaagctca                                                   20


<210> 16366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16366
cagctagggc aaaggaagct                                                   20


<210> 16367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16367
ggctacagct agggcaaagg                                                   20


<210> 16368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16368
cctggctaca gctagggcaa                                                   20


<210> 16369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16369
tcctggctac agctagggca                                                   20


<210> 16370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16370
ctgactcctg gctacagcta                                                   20


<210> 16371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16371
tctgactcct ggctacagct                                                   20


<210> 16372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16372
ctctgactcc tggctacagc                                                   20


<210> 16373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16373
tcccctctga ctcctggcta                                                   20


<210> 16374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16374
gggtcctccc ctctgactcc                                                   20


<210> 16375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16375
gtgggaacac gtggggtttg                                                   20


<210> 16376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16376
agtgggaaca cgtggggttt                                                   20


<210> 16377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16377
cagtgggaac acgtggggtt                                                   20


<210> 16378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16378
tggctcagtg ggaacacgtg                                                   20


<210> 16379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16379
gtggctcagt gggaacacgt                                                   20


<210> 16380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16380
agtggctcag tgggaacacg                                                   20


<210> 16381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16381
gtgaatgtga gtggctcagt                                                   20


<210> 16382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16382
tgtgaatgtg agtggctcag                                                   20


<210> 16383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16383
cattgtgaat gtgagtggct                                                   20


<210> 16384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16384
ttcctcattg tgaatgtgag                                                   20


<210> 16385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16385
gacttcctca ttgtgaatgt                                                   20


<210> 16386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16386
caccaatgcc tggtgctggc                                                   20


<210> 16387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16387
acttcaccaa tgcctggtgc                                                   20


<210> 16388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16388
aaaagtactt caccaatgcc                                                   20


<210> 16389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16389
gggtggccta tggcttcaaa                                                   20


<210> 16390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16390
ctgcttaagt gggtggccta                                                   20


<210> 16391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16391
cgagatgctg cttaagtggg                                                   20


<210> 16392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16392
gttcgagatg ctgcttaagt                                                   20


<210> 16393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16393
tgttcgagat gctgcttaag                                                   20


<210> 16394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16394
ttgtgttcga gatgctgctt                                                   20


<210> 16395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16395
tcacctttat ctttgtgttc                                                   20


<210> 16396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16396
tttgctggag tacactgaca                                                   20


<210> 16397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16397
ctttgctgga gtacactgac                                                   20


<210> 16398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16398
gctttgctgg agtacactga                                                   20


<210> 16399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16399
ccacggtgaa agctttgctg                                                   20


<210> 16400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16400
gcccacggtg aaagctttgc                                                   20


<210> 16401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16401
ggaccagaag cccacggtga                                                   20


<210> 16402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16402
ttacctggac cagaagccca                                                   20


<210> 16403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16403
aagactatta cctggaccag                                                   20


<210> 16404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16404
ttgaagacta ttacctggac                                                   20


<210> 16405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16405
ggcctttgaa gactattacc                                                   20


<210> 16406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16406
ttcttccttc caggcctttg                                                   20


<210> 16407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16407
ctgcatcctt tcttccttcc                                                   20


<210> 16408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16408
tctgcatcct ttcttccttc                                                   20


<210> 16409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16409
cccagtgctg tgggtccagg                                                   20


<210> 16410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16410
ggccccagtg ctgtgggtcc                                                   20


<210> 16411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16411
gggccccagt gctgtgggtc                                                   20


<210> 16412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16412
agtctgggcc ccagtgctgt                                                   20


<210> 16413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16413
cagtctgggc cccagtgctg                                                   20


<210> 16414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16414
ttccctatca gtctgggccc                                                   20


<210> 16415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16415
gggtccttcc ctatcagtct                                                   20


<210> 16416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16416
tgggtccttc cctatcagtc                                                   20


<210> 16417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16417
ctggctgggt ccttccctat                                                   20


<210> 16418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16418
gactgtggtc agggctggct                                                   20


<210> 16419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16419
ggactgtggt cagggctggc                                                   20


<210> 16420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16420
ccagggactg tggtcagggc                                                   20


<210> 16421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16421
ccttccaggg actgtggtca                                                   20


<210> 16422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16422
cccttccagg gactgtggtc                                                   20


<210> 16423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16423
ccccttccag ggactgtggt                                                   20


<210> 16424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16424
aaatcccctt ccagggactg                                                   20


<210> 16425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16425
gactaccaaa tccccttcca                                                   20


<210> 16426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16426
tgactaccaa atccccttcc                                                   20


<210> 16427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16427
ctgactacca aatccccttc                                                   20


<210> 16428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16428
gcaaacaaaa tgctactggc                                                   20


<210> 16429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16429
cacagcaaac aaaatgctac                                                   20


<210> 16430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16430
tatcccactt tacctcccca                                                   20


<210> 16431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16431
aagtcatgct ttggatctca                                                   20


<210> 16432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16432
gccctgaaga agtcatgctt                                                   20


<210> 16433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16433
tgtccccatt ggccctgaag                                                   20


<210> 16434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16434
gtttgtcccc attggccctg                                                   20


<210> 16435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16435
gcagggctgt ttgtccccat                                                   20


<210> 16436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16436
catccctgca agtatcagca                                                   20


<210> 16437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16437
gcatccctgc aagtatcagc                                                   20


<210> 16438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16438
agcatccctg caagtatcag                                                   20


<210> 16439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16439
ttcagcatcc ctgcaagtat                                                   20


<210> 16440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16440
cttgcattca gcatccctgc                                                   20


<210> 16441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16441
ttttctttct cccttgcatt                                                   20


<210> 16442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16442
ttccaaaatc caatttgaga                                                   20


<210> 16443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16443
cttccaaaat ccaatttgag                                                   20


<210> 16444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16444
tcacttccaa aatccaattt                                                   20


<210> 16445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16445
agtcactgtt agcatccctt                                                   20


<210> 16446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16446
tttttaaaca aagtcactgt                                                   20


<210> 16447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16447
gatgctttta tttttaaaca                                                   20


<210> 16448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16448
attctttttc agaggtgtgt                                                   20


<210> 16449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16449
gatagaacat tctttttcag                                                   20


<210> 16450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16450
agatagaaca ttctttttca                                                   20


<210> 16451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16451
tgagatagaa cattcttttt                                                   20


<210> 16452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16452
ttccttgatt accagtgaga                                                   20


<210> 16453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16453
gaatttcctt gattaccagt                                                   20


<210> 16454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16454
atttgaattt ccttgattac                                                   20


<210> 16455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16455
ccagtctgat aaaagaaaaa                                                   20


<210> 16456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16456
catctccacc agtctgataa                                                   20


<210> 16457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16457
ctattctttt ccatctccac                                                   20


<210> 16458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16458
cccacagcca cagcatccta                                                   20


<210> 16459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16459
ccccacagcc acagcatcct                                                   20


<210> 16460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16460
cccccacagc cacagcatcc                                                   20


<210> 16461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16461
gtggcagccc cccacagcca                                                   20


<210> 16462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16462
aaaagagtgg cagcccccca                                                   20


<210> 16463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16463
aaaaaaaaaa aaaagagtgg                                                   20


<210> 16464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16464
aaaaaaaaaa aaaaaaagag                                                   20


<210> 16465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16465
aaaaaaaaaa aaaaaaaaaa                                                   20


<210> 16466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16466
aaaaaaaaaa aaaaaaaaaa                                                   20


<210> 16467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16467
tccagcctgg gcgacagagc                                                   20


<210> 16468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16468
gcactccagc ctgggcgaca                                                   20


<210> 16469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16469
ctgcactcca gcctgggcga                                                   20


<210> 16470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16470
ccgctactgc actccagcct                                                   20


<210> 16471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16471
cccgctactg cactccagcc                                                   20


<210> 16472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16472
gagatcccgc tactgcactc                                                   20


<210> 16473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16473
ggcagagctt gcagtgagcc                                                   20


<210> 16474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16474
tgggaggcag agcttgcagt                                                   20


<210> 16475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16475
aacctgggag gcagagcttg                                                   20


<210> 16476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16476
tggcgtgaac ctgggaggca                                                   20


<210> 16477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16477
aatggcgtga acctgggagg                                                   20


<210> 16478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16478
gagaatggcg tgaacctggg                                                   20


<210> 16479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16479
ggagaatggc gtgaacctgg                                                   20


<210> 16480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16480
caggagaatg gcgtgaacct                                                   20


<210> 16481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16481
gcaggagaat ggcgtgaacc                                                   20


<210> 16482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16482
gggaggctga ggcaggagaa                                                   20


<210> 16483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16483
tacttgggag gctgaggcag                                                   20


<210> 16484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16484
gctacttggg aggctgaggc                                                   20


<210> 16485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16485
agctacttgg gaggctgagg                                                   20


<210> 16486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16486
cccagctact tgggaggctg                                                   20


<210> 16487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16487
tcccagctac ttgggaggct                                                   20


<210> 16488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16488
tgtagtccca gctacttggg                                                   20


<210> 16489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16489
ctgtagtccc agctacttgg                                                   20


<210> 16490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16490
gcctgtagtc ccagctactt                                                   20


<210> 16491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16491
cgcctgtagt cccagctact                                                   20


<210> 16492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16492
gtggcgggcg cctgtagtcc                                                   20


<210> 16493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16493
ggcgtagtgg cgggcgcctg                                                   20


<210> 16494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16494
aattagccgg gcgtagtggc                                                   20


<210> 16495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16495
aaattagccg ggcgtagtgg                                                   20


<210> 16496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16496
aaaaaattag ccgggcgtag                                                   20


<210> 16497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16497
tacaaaaaat tagccgggcg                                                   20


<210> 16498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16498
aaaaatacaa aaaattagcc                                                   20


<210> 16499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16499
taaaaataca aaaaattagc                                                   20


<210> 16500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16500
ctactaaaaa tacaaaaaat                                                   20


<210> 16501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16501
cgagaccatc ccggctaaaa                                                   20


<210> 16502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16502
tcaggagatc gagaccatcc                                                   20


<210> 16503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16503
gatcatgagg tcaggagatc                                                   20


<210> 16504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16504
cgggcggatc atgaggtcag                                                   20


<210> 16505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16505
ggcgggcgga tcatgaggtc                                                   20


<210> 16506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16506
aggcgggcgg atcatgaggt                                                   20


<210> 16507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16507
gctgaggcgg gcggatcatg                                                   20


<210> 16508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16508
ggctgaggcg ggcggatcat                                                   20


<210> 16509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16509
ctttgggagg ctgaggcggg                                                   20


<210> 16510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16510
gcactttggg aggctgaggc                                                   20


<210> 16511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16511
agcactttgg gaggctgagg                                                   20


<210> 16512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16512
cccagcactt tgggaggctg                                                   20


<210> 16513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16513
tcccagcact ttgggaggct                                                   20


<210> 16514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16514
tgtaatccca gcactttggg                                                   20


<210> 16515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16515
ctgtaatccc agcactttgg                                                   20


<210> 16516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16516
gcctgtaatc ccagcacttt                                                   20


<210> 16517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16517
cgcctgtaat cccagcactt                                                   20


<210> 16518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16518
gtggctcacg cctgtaatcc                                                   20


<210> 16519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16519
gtaagagtgg ccgggcgcgg                                                   20


<210> 16520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16520
cttgtaagag tggccgggcg                                                   20


<210> 16521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16521
agtcacttgt aagagtggcc                                                   20


<210> 16522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16522
cagtcacttg taagagtggc                                                   20


<210> 16523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16523
ctgccagtca cttgtaagag                                                   20


<210> 16524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16524
ctcctgccag tcacttgtaa                                                   20


<210> 16525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16525
cactcctgcc agtcacttgt                                                   20


<210> 16526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16526
ggccaggttt tcactcctgc                                                   20


<210> 16527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16527
ggcttcacac aggactggcc                                                   20


<210> 16528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16528
tggcttcaca caggactggc                                                   20


<210> 16529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16529
aatttggctt cacacaggac                                                   20


<210> 16530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16530
ttgccaattt ggcttcacac                                                   20


<210> 16531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16531
attgccaatt tggcttcaca                                                   20


<210> 16532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16532
tctgagtcac attgccaatt                                                   20


<210> 16533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16533
gctaggttcc tgaaacctct                                                   20


<210> 16534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16534
tgcttgaagg aggaattgct                                                   20


<210> 16535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16535
gtgcttgaag gaggaattgc                                                   20


<210> 16536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16536
ttaggattag tgcttgaagg                                                   20


<210> 16537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16537
cttaggatta gtgcttgaag                                                   20


<210> 16538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16538
tccttaggat tagtgcttga                                                   20


<210> 16539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16539
gtccttagga ttagtgcttg                                                   20


<210> 16540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16540
gcctccagtg tccttaggat                                                   20


<210> 16541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16541
caacagcctc cagtgtcctt                                                   20


<210> 16542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16542
ccaacagcct ccagtgtcct                                                   20


<210> 16543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16543
gagtgggcac caacagcctc                                                   20


<210> 16544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16544
aggacctgag tgggcaccaa                                                   20


<210> 16545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16545
cccttaaaga ggacctgagt                                                   20


<210> 16546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16546
ccccttaaag aggacctgag                                                   20


<210> 16547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16547
tggcccctta aagaggacct                                                   20


<210> 16548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16548
ggggcactgg ccccttaaag                                                   20


<210> 16549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16549
aggggcactg gccccttaaa                                                   20


<210> 16550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16550
ataggggcac tggcccctta                                                   20


<210> 16551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16551
cagatgaagg ataggggcac                                                   20


<210> 16552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16552
tcccagcaga tgaaggatag                                                   20


<210> 16553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16553
ctcccagcag atgaaggata                                                   20


<210> 16554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16554
actcccagca gatgaaggat                                                   20


<210> 16555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16555
cactcccagc agatgaagga                                                   20


<210> 16556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16556
ccgacactcc cagcagatga                                                   20


<210> 16557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16557
gccgacactc ccagcagatg                                                   20


<210> 16558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16558
ttagcagccg acactcccag                                                   20


<210> 16559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16559
ctattagcag ccgacactcc                                                   20


<210> 16560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16560
ctgcatccat gaactattag                                                   20


<210> 16561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16561
tgtctgcatc catgaactat                                                   20


<210> 16562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16562
cagcgaagcc atcaggaagg                                                   20


<210> 16563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16563
ccagcgaagc catcaggaag                                                   20


<210> 16564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16564
cccagcgaag ccatcaggaa                                                   20


<210> 16565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16565
gcccagcgaa gccatcagga                                                   20


<210> 16566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16566
agcccagcga agccatcagg                                                   20


<210> 16567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16567
tccagcccag cgaagccatc                                                   20


<210> 16568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16568
ctccagccca gcgaagccat                                                   20


<210> 16569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16569
cagtttcctc cagcccagcg                                                   20


<210> 16570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16570
ggacacagtt tcctccagcc                                                   20


<210> 16571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16571
aaggtggaca cagtttcctc                                                   20


<210> 16572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16572
agcatttccc aaggtggaca                                                   20


<210> 16573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16573
aggataagca tttcccaagg                                                   20


<210> 16574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16574
gggaggataa gcatttccca                                                   20


<210> 16575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16575
ggggaggata agcatttccc                                                   20


<210> 16576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16576
gctgccccag cggggaggat                                                   20


<210> 16577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16577
tgagggctgc cccagcgggg                                                   20


<210> 16578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16578
ctgagggctg ccccagcggg                                                   20


<210> 16579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16579
ggctgagggc tgccccagcg                                                   20


<210> 16580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16580
tggctgaggg ctgccccagc                                                   20


<210> 16581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16581
ctggctgagg gctgccccag                                                   20


<210> 16582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16582
tccctggctg agggctgccc                                                   20


<210> 16583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16583
ctgtcactgt ccctggctga                                                   20


<210> 16584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16584
cctgtcactg tccctggctg                                                   20


<210> 16585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16585
ccctgtcact gtccctggct                                                   20


<210> 16586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16586
aatccccctg tcactgtccc                                                   20


<210> 16587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16587
ccaccttgag gcaaagaaga                                                   20


<210> 16588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16588
tgtcccacct tgaggcaaag                                                   20


<210> 16589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16589
agctgtccca ccttgaggca                                                   20


<210> 16590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16590
caaagagctg tcccaccttg                                                   20


<210> 16591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16591
ccaaagagct gtcccacctt                                                   20


<210> 16592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16592
gaagcacaaa ggacaccaaa                                                   20


<210> 16593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16593
ctgaagcaca aaggacacca                                                   20


<210> 16594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16594
tggaaagccc tgaagcacaa                                                   20


<210> 16595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16595
atggaaagcc ctgaagcaca                                                   20


<210> 16596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16596
tgatcccatg gaaagccctg                                                   20


<210> 16597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16597
gcttcagctg atcccatgga                                                   20


<210> 16598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16598
tccggcttca gctgatccca                                                   20


<210> 16599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16599
gttcagttga aatccggctt                                                   20


<210> 16600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16600
atgtgggttc agttgaaatc                                                   20


<210> 16601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16601
gctgagaaaa gatgtgggtt                                                   20


<210> 16602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16602
cggaagctga gaaaagatgt                                                   20


<210> 16603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16603
tcggaagctg agaaaagatg                                                   20


<210> 16604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16604
acagaatcgg aagctgagaa                                                   20


<210> 16605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16605
tagacacaga atcggaagct                                                   20


<210> 16606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16606
cgtcctagac acagaatcgg                                                   20


<210> 16607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16607
cctcgtccta gacacagaat                                                   20


<210> 16608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16608
cttagtcctc gtcctagaca                                                   20


<210> 16609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16609
tcccatctta gtcctcgtcc                                                   20


<210> 16610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16610
cgttggataa tctcccatct                                                   20


<210> 16611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16611
gtgtactccc ttagagacgt                                                   20


<210> 16612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16612
tccctgtgtg tactccctta                                                   20


<210> 16613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16613
attccctgtg tgtactccct                                                   20


<210> 16614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16614
tctcatatta tctcatttaa                                                   20


<210> 16615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16615
agtacatttt tctcagtaaa                                                   20


<210> 16616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16616
taacctcagt acatttttct                                                   20


<210> 16617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16617
atttatgcat tctataacct                                                   20


<210> 16618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16618
aaactcactt gaaaacatgc                                                   20


<210> 16619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16619
ccatttccct atcactcaaa                                                   20


<210> 16620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16620
atccatttcc ctatcactca                                                   20


<210> 16621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16621
ggaaattata gaaaaaggta                                                   20


<210> 16622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16622
tacttggaaa ttatagaaaa                                                   20


<210> 16623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16623
atacttggaa attatagaaa                                                   20


<210> 16624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16624
aaaaaaatac ttggaaatta                                                   20


<210> 16625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16625
taaagtacca aaaaaatact                                                   20


<210> 16626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16626
cattttcatc tgacaaagta                                                   20


<210> 16627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16627
acatgcattt tcatctgaca                                                   20


<210> 16628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16628
cttctttagg ctttcacttt                                                   20


<210> 16629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16629
caccaaattt agccttcttt                                                   20


<210> 16630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16630
gcaccaaatt tagccttctt                                                   20


<210> 16631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16631
gaacaggctg gcaccaaatt                                                   20


<210> 16632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16632
tcccctggga ctgaacaggc                                                   20


<210> 16633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16633
tccttcccct gggactgaac                                                   20


<210> 16634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16634
ctccttcccc tgggactgaa                                                   20


<210> 16635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16635
ccctcccatc tccttcccct                                                   20


<210> 16636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16636
tccctcccat ctccttcccc                                                   20


<210> 16637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16637
ccagcccagc ccgccccctg                                                   20


<210> 16638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16638
cctgcagcac tgcgccagcc                                                   20


<210> 16639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16639
tcagacctgc agcactgcgc                                                   20


<210> 16640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16640
caggaggaag ctcagacctg                                                   20


<210> 16641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16641
cacattccca ggaggaagct                                                   20


<210> 16642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16642
ccccccacat tcccaggagg                                                   20


<210> 16643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16643
ccacccccca cattcccagg                                                   20


<210> 16644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16644
tccacccccc acattcccag                                                   20


<210> 16645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16645
ggtccacccc ccacattccc                                                   20


<210> 16646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16646
cggtccaccc cccacattcc                                                   20


<210> 16647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16647
gcccccttct cttcacaccc                                                   20


<210> 16648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16648
tgctccctcc cttctctctc                                                   20


<210> 16649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16649
tcactacgtc attggcttgt                                                   20


<210> 16650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16650
ctcactacgt cattggcttg                                                   20


<210> 16651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16651
tgctctcctc actacgtcat                                                   20


<210> 16652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16652
aaccacatgt gctgttggcc                                                   20


<210> 16653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16653
taaccacatg tgctgttggc                                                   20


<210> 16654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16654
gtaataacca catgtgctgt                                                   20


<210> 16655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16655
cttccagtcc tgctggatta                                                   20


<210> 16656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16656
tcttctcctt ccagtcctgc                                                   20


<210> 16657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16657
cacctatgct cttctccttc                                                   20


<210> 16658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16658
aggggcaaga gagggctggg                                                   20


<210> 16659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16659
tgcaggggca agagagggct                                                   20


<210> 16660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16660
ttgcaggggc aagagagggc                                                   20


<210> 16661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16661
caaattgcag gggcaagaga                                                   20


<210> 16662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16662
ccaaattgca ggggcaagag                                                   20


<210> 16663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16663
gccaaattgc aggggcaaga                                                   20


<210> 16664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16664
aggccaaatt gcaggggcaa                                                   20


<210> 16665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16665
agaggccaaa ttgcaggggc                                                   20


<210> 16666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16666
gtgtagaggc caaattgcag                                                   20


<210> 16667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16667
agtgtagagg ccaaattgca                                                   20


<210> 16668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16668
cagtgtagag gccaaattgc                                                   20


<210> 16669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16669
acagtgtaga ggccaaattg                                                   20


<210> 16670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16670
cggacctcag cacagtgtag                                                   20


<210> 16671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16671
acggacctca gcacagtgta                                                   20


<210> 16672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16672
acacggacct cagcacagtg                                                   20


<210> 16673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16673
tgtccacacg gacctcagca                                                   20


<210> 16674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16674
gtgattgtcc acacggacct                                                   20


<210> 16675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16675
cagggcagtg attgtccaca                                                   20


<210> 16676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16676
cccagtgccc tggcacaggg                                                   20


<210> 16677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16677
gtgcccagtg ccctggcaca                                                   20


<210> 16678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16678
ggtgcccagt gccctggcac                                                   20


<210> 16679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16679
aggtgcccag tgccctggca                                                   20


<210> 16680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16680
gctgcaggtg cccagtgccc                                                   20


<210> 16681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16681
tgacagcggc tgcaggtgcc                                                   20


<210> 16682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16682
aactgtgtga cagcggctgc                                                   20


<210> 16683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16683
gaactgtgtg acagcggctg                                                   20


<210> 16684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16684
gagggggaac tgtgtgacag                                                   20


<210> 16685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16685
gtggaggggg aactgtgtga                                                   20


<210> 16686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16686
tctgccatcc tgggtggagg                                                   20


<210> 16687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16687
gtctgccatc ctgggtggag                                                   20


<210> 16688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16688
ggtctgccat cctgggtgga                                                   20


<210> 16689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16689
tggtctgcca tcctgggtgg                                                   20


<210> 16690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16690
ctggtctgcc atcctgggtg                                                   20


<210> 16691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16691
gactggtctg ccatcctggg                                                   20


<210> 16692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16692
agggactggt ctgccatcct                                                   20


<210> 16693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16693
cagggactgg tctgccatcc                                                   20


<210> 16694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16694
gagagtttcg gggcagggac                                                   20


<210> 16695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16695
gagaagagag tttcggggca                                                   20


<210> 16696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16696
ggagaagaga gtttcggggc                                                   20


<210> 16697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16697
gggagaagag agtttcgggg                                                   20


<210> 16698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16698
caagggagaa gagagtttcg                                                   20


<210> 16699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16699
ccaagggaga agagagtttc                                                   20


<210> 16700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16700
gccaagggag aagagagttt                                                   20


<210> 16701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16701
cgcaaagcca agggagaaga                                                   20


<210> 16702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16702
gacgcaaagc caagggagaa                                                   20


<210> 16703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16703
atgacgcaaa gccaagggag                                                   20


<210> 16704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16704
gcaatgacgc aaagccaagg                                                   20


<210> 16705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16705
tggcaatgac gcaaagccaa                                                   20


<210> 16706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16706
gtggcaatga cgcaaagcca                                                   20


<210> 16707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16707
ggtggcaatg acgcaaagcc                                                   20


<210> 16708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16708
actagggtgg caatgacgca                                                   20


<210> 16709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16709
aggtgggagg aaaactaggg                                                   20


<210> 16710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16710
gagaggtggg aggaaaacta                                                   20


<210> 16711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16711
tgagaggtgg gaggaaaact                                                   20


<210> 16712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16712
ctgagaggtg ggaggaaaac                                                   20


<210> 16713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16713
ggcaggatct gagaggtggg                                                   20


<210> 16714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16714
aggcaggatc tgagaggtgg                                                   20


<210> 16715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16715
cgaggcagga tctgagaggt                                                   20


<210> 16716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16716
acgaggcagg atctgagagg                                                   20


<210> 16717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16717
gggacgaggc aggatctgag                                                   20


<210> 16718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16718
cgggacgagg caggatctga                                                   20


<210> 16719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16719
tgcgggacga ggcaggatct                                                   20


<210> 16720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16720
gcacaggtgc gggacgaggc                                                   20


<210> 16721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16721
agcacaggtg cgggacgagg                                                   20


<210> 16722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16722
aggagcacag gtgcgggacg                                                   20


<210> 16723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16723
gaggagcaca ggtgcgggac                                                   20


<210> 16724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16724
ttagggagga gcacaggtgc                                                   20


<210> 16725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16725
tttagggagg agcacaggtg                                                   20


<210> 16726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16726
tcagctttag ggaggagcac                                                   20


<210> 16727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16727
ctcagcttta gggaggagca                                                   20


<210> 16728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16728
atggcctcag ctttagggag                                                   20


<210> 16729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16729
gcatggcctc agctttaggg                                                   20


<210> 16730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16730
tgcatggcct cagctttagg                                                   20


<210> 16731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16731
ggtgcatggc ctcagcttta                                                   20


<210> 16732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16732
cggtgcatgg cctcagcttt                                                   20


<210> 16733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16733
tcggtgcatg gcctcagctt                                                   20


<210> 16734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16734
aactgctcgg tgcatggcct                                                   20


<210> 16735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16735
tgacaaaact gctcggtgca                                                   20


<210> 16736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16736
ggaagggtga caaaactgct                                                   20


<210> 16737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16737
aatgccagat tgtccaggaa                                                   20


<210> 16738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16738
aaatgccaga ttgtccagga                                                   20


<210> 16739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16739
taaatgccag attgtccagg                                                   20


<210> 16740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16740
atctaaatgc cagattgtcc                                                   20


<210> 16741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16741
catctaaatg ccagattgtc                                                   20


<210> 16742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16742
ctaggcctcc atctaaatgc                                                   20


<210> 16743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16743
aaacaaccta ctaaatatct                                                   20


<210> 16744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16744
aaaacaacct actaaatatc                                                   20


<210> 16745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16745
gctcttccga ttcacggctg                                                   20


<210> 16746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16746
agtcccgctc ttccgattca                                                   20


<210> 16747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16747
tagttgaagg gctaggacta                                                   20


<210> 16748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16748
agctaattag ttgaagggct                                                   20


<210> 16749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16749
cagctaatta gttgaagggc                                                   20


<210> 16750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16750
gtggcagcta attagttgaa                                                   20


<210> 16751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16751
ggtggcagct aattagttga                                                   20


<210> 16752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16752
gggtggcagc taattagttg                                                   20


<210> 16753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16753
agttcagggt ggcagctaat                                                   20


<210> 16754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16754
gaatagagag ttcagggtgg                                                   20


<210> 16755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16755
tgggaataga gagttcaggg                                                   20


<210> 16756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16756
ggctgggaat agagagttca                                                   20


<210> 16757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16757
gggctgggaa tagagagttc                                                   20


<210> 16758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16758
agggctggga atagagagtt                                                   20


<210> 16759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16759
gttgaagggc tgggaataga                                                   20


<210> 16760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16760
tagttgaagg gctgggaata                                                   20


<210> 16761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16761
attagttgaa gggctgggaa                                                   20


<210> 16762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16762
aggtaattag ttgaagggct                                                   20


<210> 16763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16763
caggtaatta gttgaagggc                                                   20


<210> 16764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16764
gcttcaggta attagttgaa                                                   20


<210> 16765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16765
ggcttcaggt aattagttga                                                   20


<210> 16766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16766
gggcttcagg taattagttg                                                   20


<210> 16767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16767
catgaggggc ttcaggtaat                                                   20


<210> 16768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16768
ccaaaggcat gaggggcttc                                                   20


<210> 16769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16769
cccaaaggca tgaggggctt                                                   20


<210> 16770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16770
tcaaagccca aaggcatgag                                                   20


<210> 16771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16771
gtcaaagccc aaaggcatga                                                   20


<210> 16772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16772
agtcaaagcc caaaggcatg                                                   20


<210> 16773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16773
aagtcaaagc ccaaaggcat                                                   20


<210> 16774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16774
atgaggaagt caaagcccaa                                                   20


<210> 16775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16775
aatgaggaag tcaaagccca                                                   20


<210> 16776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16776
ttttctaaat gaggaagtca                                                   20


<210> 16777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16777
tttgcatttt ctaaatgagg                                                   20


<210> 16778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16778
ttgtttgcat tttctaaatg                                                   20


<210> 16779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16779
gttgtttgca ttttctaaat                                                   20


<210> 16780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16780
aggaaggaac ttaacatcct                                                   20


<210> 16781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16781
aggtagacat agacacagga                                                   20


<210> 16782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16782
aaggtagaca tagacacagg                                                   20


<210> 16783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16783
accaaggtag acatagacac                                                   20


<210> 16784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16784
gaccaaggta gacatagaca                                                   20


<210> 16785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16785
ccaatagacc aaggtagaca                                                   20


<210> 16786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16786
actccgccaa tagaccaagg                                                   20


<210> 16787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16787
actactccgc caatagacca                                                   20


<210> 16788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16788
aactactccg ccaatagacc                                                   20


<210> 16789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16789
aatctcaact actccgccaa                                                   20


<210> 16790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16790
ttctctctgt actgtggctt                                                   20


<210> 16791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16791
ggaaggttct ctctgtactg                                                   20


<210> 16792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16792
ctttgtagag caaagaagga                                                   20


<210> 16793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16793
gctttgtaga gcaaagaagg                                                   20


<210> 16794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16794
tgggctttgt agagcaaaga                                                   20


<210> 16795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16795
ctgggctttg tagagcaaag                                                   20


<210> 16796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16796
atactgggct ttgtagagca                                                   20


<210> 16797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16797
gctgaatact gggctttgta                                                   20


<210> 16798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16798
tggctgaata ctgggctttg                                                   20


<210> 16799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16799
taaggccctg gctgaatact                                                   20


<210> 16800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16800
ctaaggccct ggctgaatac                                                   20


<210> 16801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16801
gggagacatc tctaaggccc                                                   20


<210> 16802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16802
agagttggga gacatctcta                                                   20


<210> 16803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16803
cagagttggg agacatctct                                                   20


<210> 16804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16804
gaatagagat tcagagttgg                                                   20


<210> 16805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16805
gggaatagag attcagagtt                                                   20


<210> 16806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16806
tgggaataga gattcagagt                                                   20


<210> 16807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16807
cttatgggaa tagagattca                                                   20


<210> 16808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16808
gccttatggg aatagagatt                                                   20


<210> 16809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16809
aacaaggcct tatgggaata                                                   20


<210> 16810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16810
ataacaaggc cttatgggaa                                                   20


<210> 16811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16811
tttgaataac aaggccttat                                                   20


<210> 16812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16812
ctttgaataa caaggcctta                                                   20


<210> 16813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16813
gacccacact ttgaataaca                                                   20


<210> 16814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16814
tgacccacac tttgaataac                                                   20


<210> 16815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16815
ggtgatgctt gcactgccct                                                   20


<210> 16816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16816
tgcatttcta acaagctccc                                                   20


<210> 16817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16817
ttgcatttct aacaagctcc                                                   20


<210> 16818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16818
tgagaatttg catttctaac                                                   20


<210> 16819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16819
ataaatctgt ggcagggcct                                                   20


<210> 16820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16820
cattccataa atctgtggca                                                   20


<210> 16821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16821
tcattccata aatctgtggc                                                   20


<210> 16822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16822
ctcattccat aaatctgtgg                                                   20


<210> 16823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16823
attctcattc cataaatctg                                                   20


<210> 16824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16824
cccaggagct tgttcaaatg                                                   20


<210> 16825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16825
ctcaaaattt aatctcccag                                                   20


<210> 16826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16826
ttctcaaaat ttaatctccc                                                   20


<210> 16827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16827
cttctcaaaa tttaatctcc                                                   20


<210> 16828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16828
ctcacagaaa atcattacaa                                                   20


<210> 16829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16829
aattactcct ttaaagctca                                                   20


<210> 16830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16830
tgctactaat tactccttta                                                   20


<210> 16831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16831
tgaaggccta caatacaaaa                                                   20


<210> 16832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16832
ctgaaggcct acaatacaaa                                                   20


<210> 16833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16833
caacacacgg ccttctctga                                                   20


<210> 16834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16834
ccaacacacg gccttctctg                                                   20


<210> 16835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 16835
cctctgacct ccccaacaca                                                   20


<210> 16836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16836
ttatttaatc ccgaagcccc                                                   20


<210> 16837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16837
tttgccctta tttaatcccg                                                   20


<210> 16838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16838
aacttgtcag tagcaaaacc                                                   20


<210> 16839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16839
aaggtcaccc aacttgtcag                                                   20


<210> 16840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16840
tccaaggtca cccaacttgt                                                   20


<210> 16841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16841
atgtttaaaa ggcttgtcca                                                   20


<210> 16842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16842
aatgtttaaa aggcttgtcc                                                   20


<210> 16843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16843
tgacactcaa aatgtttaaa                                                   20


<210> 16844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16844
ctgacactca aaatgtttaa                                                   20


<210> 16845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16845
tgcctcccac tatatagatg                                                   20


<210> 16846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16846
atgcctccca ctatatagat                                                   20


<210> 16847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16847
tatgcctccc actatataga                                                   20


<210> 16848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16848
agtgtatgcc tcccactata                                                   20


<210> 16849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16849
ctgcaagcat ttgagtgagt                                                   20


<210> 16850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16850
ctggctgcaa gcatttgagt                                                   20


<210> 16851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16851
aaacctggct gcaagcattt                                                   20


<210> 16852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16852
ggcctgccaa acctggctgc                                                   20


<210> 16853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16853
gtgccatggc ctgccaaacc                                                   20


<210> 16854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16854
tgttcaaggt gcccgtgcca                                                   20


<210> 16855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16855
cagagcatgg gaggtgttca                                                   20


<210> 16856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16856
gcagagcatg ggaggtgttc                                                   20


<210> 16857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16857
tcttagcagc agagcatggg                                                   20


<210> 16858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16858
ctcttagcag cagagcatgg                                                   20


<210> 16859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16859
ccctcttagc agcagagcat                                                   20


<210> 16860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16860
cccctcttag cagcagagca                                                   20


<210> 16861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16861
gagggcccct cttagcagca                                                   20


<210> 16862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16862
gcgagggccc ctcttagcag                                                   20


<210> 16863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16863
agggcgaggg cccctcttag                                                   20


<210> 16864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16864
cccagggcga gggcccctct                                                   20


<210> 16865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16865
agagctgcag cccagggcga                                                   20


<210> 16866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16866
gagagctgca gcccagggcg                                                   20


<210> 16867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16867
ggagagctgc agcccagggc                                                   20


<210> 16868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16868
agaaggagag ctgcagccca                                                   20


<210> 16869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16869
tagaaggaga gctgcagccc                                                   20


<210> 16870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16870
ctagaaggag agctgcagcc                                                   20


<210> 16871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16871
tgtcactaga aggagagctg                                                   20


<210> 16872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16872
caaccttgtc actagaagga                                                   20


<210> 16873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16873
cccaaccttg tcactagaag                                                   20


<210> 16874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16874
tccccaacct tgtcactaga                                                   20


<210> 16875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16875
gtccccaacc ttgtcactag                                                   20


<210> 16876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16876
aaagtcccca accttgtcac                                                   20


<210> 16877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16877
tctcctgact actgagctga                                                   20


<210> 16878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16878
agtgggttct cctgactact                                                   20


<210> 16879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16879
ggccctggag ctgcatcagt                                                   20


<210> 16880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16880
aggccctgga gctgcatcag                                                   20


<210> 16881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16881
caaaggccct ggagctgcat                                                   20


<210> 16882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16882
cctacaatcc aaaggccctg                                                   20


<210> 16883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16883
ctcctacaat ccaaaggccc                                                   20


<210> 16884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16884
aggaatctcc tacaatccaa                                                   20


<210> 16885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16885
taggaatctc ctacaatcca                                                   20


<210> 16886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16886
tgcccccaaa tcctccagat                                                   20


<210> 16887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16887
ctgcccccaa atcctccaga                                                   20


<210> 16888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16888
gtccctgccc ccaaatcctc                                                   20


<210> 16889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16889
atctctggta aggggaggca                                                   20


<210> 16890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16890
agtggatctc tggtaagggg                                                   20


<210> 16891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16891
cagtggatct ctggtaaggg                                                   20


<210> 16892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16892
agcagtggat ctctggtaag                                                   20


<210> 16893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16893
cagcagtgga tctctggtaa                                                   20


<210> 16894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16894
tcagcagtgg atctctggta                                                   20


<210> 16895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16895
ctcagcagtg gatctctggt                                                   20


<210> 16896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16896
cctgctcagc agtggatctc                                                   20


<210> 16897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16897
ttcatgatcc tgctcagcag                                                   20


<210> 16898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16898
atcttcatga tcctgctcag                                                   20


<210> 16899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16899
atcatcttca tgatcctgct                                                   20


<210> 16900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16900
gtggagcaca gctggtttga                                                   20


<210> 16901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16901
tcgtggagca cagctggttt                                                   20


<210> 16902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16902
accgtatcgt ggagcacagc                                                   20


<210> 16903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16903
tgctaccgta tcgtggagca                                                   20


<210> 16904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16904
agacttgcta ccgtatcgtg                                                   20


<210> 16905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16905
caagacttgc taccgtatcg                                                   20


<210> 16906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16906
atgtgggctg gcaggtgcgc                                                   20


<210> 16907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16907
tccatgggat gtgggctggc                                                   20


<210> 16908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16908
gtccatggga tgtgggctgg                                                   20


<210> 16909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16909
agagtccatg ggatgtgggc                                                   20


<210> 16910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16910
accaagagtc catgggatgt                                                   20


<210> 16911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16911
caccaagagt ccatgggatg                                                   20


<210> 16912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16912
ggataccacc aagagtccat                                                   20


<210> 16913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16913
tggataccac caagagtcca                                                   20


<210> 16914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16914
tgcaaactgg ataccaccaa                                                   20


<210> 16915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16915
gctgcaaact ggataccacc                                                   20


<210> 16916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16916
ccactgtccc tgctgcaaac                                                   20


<210> 16917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16917
catcagtcac ctctccccac                                                   20


<210> 16918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16918
ccatcagtca cctctcccca                                                   20


<210> 16919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16919
cactggccat cacccaccat                                                   20


<210> 16920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16920
aaattatccc ctttgcccac                                                   20


<210> 16921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16921
tggtttctct gcagcaggag                                                   20


<210> 16922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16922
gaatggtttc tctgcagcag                                                   20


<210> 16923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16923
cagaatggtt tctctgcagc                                                   20


<210> 16924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16924
gcagaatggt ttctctgcag                                                   20


<210> 16925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16925
ctagcagaat ggtttctctg                                                   20


<210> 16926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16926
aagtgggttt cctagcagaa                                                   20


<210> 16927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16927
atgacaagtg ggtttcctag                                                   20


<210> 16928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16928
ggcatgacaa gtgggtttcc                                                   20


<210> 16929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16929
tttccaaggg catgacaagt                                                   20


<210> 16930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16930
ttttccaagg gcatgacaag                                                   20


<210> 16931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16931
tttttttcca agggcatgac                                                   20


<210> 16932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16932
aggaaagaat ttttttccaa                                                   20


<210> 16933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16933
caggaaagaa tttttttcca                                                   20


<210> 16934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16934
ccaggaaaga atttttttcc                                                   20


<210> 16935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16935
tcttcaccca tattccagga                                                   20


<210> 16936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16936
cccctcttca cccatattcc                                                   20


<210> 16937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16937
acccctcttc acccatattc                                                   20


<210> 16938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16938
gattgaggga ctccctggaa                                                   20


<210> 16939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16939
ggattgaggg actccctgga                                                   20


<210> 16940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16940
tggattgagg gactccctgg                                                   20


<210> 16941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16941
gtctggattg agggactccc                                                   20


<210> 16942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16942
cacctgttgg tctggattga                                                   20


<210> 16943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16943
acacctgttg gtctggattg                                                   20


<210> 16944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16944
aacacctgtt ggtctggatt                                                   20


<210> 16945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16945
gagaggaaca cctgttggtc                                                   20


<210> 16946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16946
tgatggagag gaacacctgt                                                   20


<210> 16947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16947
gggcaagact gatgatggag                                                   20


<210> 16948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16948
tgggcaagac tgatgatgga                                                   20


<210> 16949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16949
agtgggcaag actgatgatg                                                   20


<210> 16950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16950
agagtgggca agactgatga                                                   20


<210> 16951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16951
ggaaaaacat cagagtgggc                                                   20


<210> 16952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16952
gctaggaaaa acatcagagt                                                   20


<210> 16953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16953
ggctaggaaa aacatcagag                                                   20


<210> 16954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16954
tatggctagg aaaaacatca                                                   20


<210> 16955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16955
gatatggcta ggaaaaacat                                                   20


<210> 16956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16956
tctgtaagaa ggatatggct                                                   20


<210> 16957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16957
atctgtaaga aggatatggc                                                   20


<210> 16958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16958
tgtcatctgt aagaaggata                                                   20


<210> 16959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16959
cactggtgtc atctgtaaga                                                   20


<210> 16960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16960
ccactggtgt catctgtaag                                                   20


<210> 16961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16961
ggaccactgg tgtcatctgt                                                   20


<210> 16962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16962
ggcagaagga cagggaccac                                                   20


<210> 16963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16963
tataggtggg cagaaggaca                                                   20


<210> 16964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16964
gtataggtgg gcagaaggac                                                   20


<210> 16965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16965
ggtataggtg ggcagaagga                                                   20


<210> 16966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16966
tccaggtata ggtgggcaga                                                   20


<210> 16967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16967
ttccaggtat aggtgggcag                                                   20


<210> 16968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16968
gttttccagg tataggtggg                                                   20


<210> 16969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16969
tctgttttcc aggtataggt                                                   20


<210> 16970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16970
gtctgttttc caggtatagg                                                   20


<210> 16971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16971
cttgtctgtt ttccaggtat                                                   20


<210> 16972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16972
gcttgtctgt tttccaggta                                                   20


<210> 16973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16973
ccgtagcttg tctgttttcc                                                   20


<210> 16974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16974
gccgtagctt gtctgttttc                                                   20


<210> 16975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16975
acccccaggc tcatacgccg                                                   20


<210> 16976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16976
tatccccctc aggcaccccc                                                   20


<210> 16977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16977
atatccccct caggcacccc                                                   20


<210> 16978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 16978
gcttggagca tatccccctc                                                   20


<210> 16979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16979
ggcttggagc atatccccct                                                   20


<210> 16980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16980
ctcagttcag cttgggcttg                                                   20


<210> 16981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16981
ccctcagttc agcttgggct                                                   20


<210> 16982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16982
cgtggccctc agttcagctt                                                   20


<210> 16983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16983
tcgtggccct cagttcagct                                                   20


<210> 16984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16984
ccacgtcgtg gccctcagtt                                                   20


<210> 16985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16985
cccagccacg tcgtggccct                                                   20


<210> 16986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16986
tccccatccc agccacgtcg                                                   20


<210> 16987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 16987
gctggaccca atccccatcc                                                   20


<210> 16988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16988
tgggctgggc tgagctgggc                                                   20


<210> 16989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16989
accctgggct gggctgagct                                                   20


<210> 16990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16990
gaccctgggc tgggctgagc                                                   20


<210> 16991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16991
atttgaccct gggctgggct                                                   20


<210> 16992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16992
gttttatttg accctgggct                                                   20


<210> 16993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16993
agttttattt gaccctgggc                                                   20


<210> 16994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 16994
taatagtttt atttgaccct                                                   20


<210> 16995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16995
ttaatagttt tatttgaccc                                                   20


<210> 16996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 16996
aatacttgag tttttattaa                                                   20


<210> 16997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 16997
gaaaaatttt ttaaatactt                                                   20


<210> 16998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 16998
caatgctttc taaaaataca                                                   20


<210> 16999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 16999
ccattctata aagggaattg                                                   20


<210> 17000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17000
tcaagagtcc attctataaa                                                   20


<210> 17001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17001
atcaagagtc cattctataa                                                   20


<210> 17002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17002
aatcaagagt ccattctata                                                   20


<210> 17003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17003
ttgtgcaatg aatgaatcaa                                                   20


<210> 17004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17004
atttgtgcaa tgaatgaatc                                                   20


<210> 17005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17005
tctcagtgtt tagaacagtg                                                   20


<210> 17006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17006
ctctcagtgt ttagaacagt                                                   20


<210> 17007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17007
tttcctctca gtgtttagaa                                                   20


<210> 17008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17008
tcatctttcc tctcagtgtt                                                   20


<210> 17009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17009
gtcttagtca tctttcctct                                                   20


<210> 17010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17010
caaaagcaga acctgtgtct                                                   20


<210> 17011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17011
ttttgtttag ctctcaaaag                                                   20


<210> 17012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17012
atcttttgtt tagctctcaa                                                   20


<210> 17013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17013
gcttccctca atcttttgtt                                                   20


<210> 17014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17014
accatgaagg acccagagga                                                   20


<210> 17015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17015
gaccatgaag gacccagagg                                                   20


<210> 17016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17016
ttggaccatg aaggacccag                                                   20


<210> 17017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17017
tttggaccat gaaggaccca                                                   20


<210> 17018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17018
gatttggacc atgaaggacc                                                   20


<210> 17019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17019
actcttgatt tggaccatga                                                   20


<210> 17020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17020
aactcttgat ttggaccatg                                                   20


<210> 17021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17021
accactgaaa actcttgatt                                                   20


<210> 17022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17022
tgagttgaaa gggggaaacg                                                   20


<210> 17023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17023
agccctcttg agttgaaagg                                                   20


<210> 17024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17024
cagccctctt gagttgaaag                                                   20


<210> 17025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17025
ccagccctct tgagttgaaa                                                   20


<210> 17026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17026
accagccctc ttgagttgaa                                                   20


<210> 17027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17027
aaccagccct cttgagttga                                                   20


<210> 17028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17028
agttctaaac cagccctctt                                                   20


<210> 17029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17029
cccctccgtg agttctaaac                                                   20


<210> 17030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17030
accctcaaaa acccctccgt                                                   20


<210> 17031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17031
cagacactac ggagagacgt                                                   20


<210> 17032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17032
tcagacacta cggagagacg                                                   20


<210> 17033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17033
gccctatcag acactacgga                                                   20


<210> 17034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17034
atgccctatc agacactacg                                                   20


<210> 17035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17035
tcatgcccta tcagacacta                                                   20


<210> 17036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17036
atctgcatct catgccctat                                                   20


<210> 17037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17037
aggtggcagc agcctggccg                                                   20


<210> 17038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17038
tgccccaggt ggcagcagcc                                                   20


<210> 17039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17039
acacatgccc caggtggcag                                                   20


<210> 17040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17040
gacacacatg ccccaggtgg                                                   20


<210> 17041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17041
tcagacacac atgccccagg                                                   20


<210> 17042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17042
gcatcagaca cacatgcccc                                                   20


<210> 17043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17043
cgcatcagac acacatgccc                                                   20


<210> 17044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17044
aggcttgagg gcgcccgcat                                                   20


<210> 17045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17045
tgcctcactc ccaggcttga                                                   20


<210> 17046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17046
ctgcctcact cccaggcttg                                                   20


<210> 17047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17047
gctgcctcac tcccaggctt                                                   20


<210> 17048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17048
ccacttgctg cctcactccc                                                   20


<210> 17049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17049
cccacttgct gcctcactcc                                                   20


<210> 17050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17050
gggatccaca gaagacaaac                                                   20


<210> 17051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17051
cactcacctg ggatccacag                                                   20


<210> 17052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17052
gaacactcac ctgggatcca                                                   20


<210> 17053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17053
agttgagcga acactcacct                                                   20


<210> 17054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17054
cagttgagcg aacactcacc                                                   20


<210> 17055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17055
attagggcca gaatccagtt                                                   20


<210> 17056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17056
tgttaattag ggccagaatc                                                   20


<210> 17057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17057
acactgatgt taattagggc                                                   20


<210> 17058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17058
cctcacactg atgttaatta                                                   20


<210> 17059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17059
ccctcacact gatgttaatt                                                   20


<210> 17060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17060
cccctcacac tgatgttaat                                                   20


<210> 17061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17061
gaaggtgaag ggacagccac                                                   20


<210> 17062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17062
agaaggtgaa gggacagcca                                                   20


<210> 17063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17063
cttcacagaa ggtgaaggga                                                   20


<210> 17064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17064
actgcttcac agaaggtgaa                                                   20


<210> 17065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17065
gactgcttca cagaaggtga                                                   20


<210> 17066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17066
tgactgcttc acagaaggtg                                                   20


<210> 17067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17067
ccagatgact gcttcacaga                                                   20


<210> 17068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17068
accagatgac tgcttcacag                                                   20


<210> 17069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17069
agaaccagat gactgcttca                                                   20


<210> 17070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17070
ggcagatgac ctggaagaac                                                   20


<210> 17071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17071
tgagctggca gatgacctgg                                                   20


<210> 17072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17072
ccctgagctg gcagatgacc                                                   20


<210> 17073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17073
gaggaagatc cctgagctgg                                                   20


<210> 17074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17074
cctgaggaag atccctgagc                                                   20


<210> 17075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17075
aaatcctgag gaagatccct                                                   20


<210> 17076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17076
atcctgagga aatcctgagg                                                   20


<210> 17077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17077
tagatcctga ggaaatcctg                                                   20


<210> 17078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17078
ctagatcctg aggaaatcct                                                   20


<210> 17079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17079
ggtggactgc ctagatcctg                                                   20


<210> 17080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17080
cggtggactg cctagatcct                                                   20


<210> 17081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17081
gggcagcacg gtggactgcc                                                   20


<210> 17082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17082
ctcctctgag ggcagcacgg                                                   20


<210> 17083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17083
aagctcctct gagggcagca                                                   20


<210> 17084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17084
gacacaagct cctctgaggg                                                   20


<210> 17085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17085
gacgacacaa gctcctctga                                                   20


<210> 17086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17086
ggacgacaca agctcctctg                                                   20


<210> 17087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17087
tggacgacac aagctcctct                                                   20


<210> 17088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17088
ctgcagggag tggacgacac                                                   20


<210> 17089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17089
ggcttctccc ctgcagggag                                                   20


<210> 17090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17090
ctgggcttct cccctgcagg                                                   20


<210> 17091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17091
ccctgggctt ctcccctgca                                                   20


<210> 17092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17092
gccctgggct tctcccctgc                                                   20


<210> 17093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17093
tgccctgggc ttctcccctg                                                   20


<210> 17094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17094
agagacgagt tcactgccct                                                   20


<210> 17095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17095
gagagacgag ttcactgccc                                                   20


<210> 17096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17096
cccgggcccc gcggagagac                                                   20


<210> 17097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17097
aattccccgg gccccgcgga                                                   20


<210> 17098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17098
gcaattcccc gggccccgcg                                                   20


<210> 17099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17099
gtgcaattcc ccgggccccg                                                   20


<210> 17100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17100
gtgaccgtgt gcaattcccc                                                   20


<210> 17101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17101
agtgaccgtg tgcaattccc                                                   20


<210> 17102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17102
catgggtgca gttgaacctg                                                   20


<210> 17103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17103
cgaggcacca aacatgggtg                                                   20


<210> 17104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17104
gctggcgagg caccaaacat                                                   20


<210> 17105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17105
agctggcgag gcaccaaaca                                                   20


<210> 17106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17106
gttccaggcc tcagctggcg                                                   20


<210> 17107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17107
tgttccaggc ctcagctggc                                                   20


<210> 17108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17108
gcagtgttcc aggcctcagc                                                   20


<210> 17109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17109
aagagcagtg ttccaggcct                                                   20


<210> 17110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17110
agggagaaga gcagtgttcc                                                   20


<210> 17111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17111
cagggagaag agcagtgttc                                                   20


<210> 17112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17112
tggggctcca gggagaagag                                                   20


<210> 17113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17113
ctctggggct ccagggagaa                                                   20


<210> 17114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17114
gcctctgggg ctccagggag                                                   20


<210> 17115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17115
taagcctctg gggctccagg                                                   20


<210> 17116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17116
gctaagcctc tggggctcca                                                   20


<210> 17117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17117
agctaagcct ctggggctcc                                                   20


<210> 17118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17118
cagctaagcc tctggggctc                                                   20


<210> 17119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17119
ctcacacagc taagcctctg                                                   20


<210> 17120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17120
tctcacacag ctaagcctct                                                   20


<210> 17121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17121
gtctcacaca gctaagcctc                                                   20


<210> 17122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17122
gtttacagtc tcacacagct                                                   20


<210> 17123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17123
cgaaggttta cagtctcaca                                                   20


<210> 17124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17124
tcaggggccc cgaaggttta                                                   20


<210> 17125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17125
cactccatca ggggccccga                                                   20


<210> 17126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17126
gcactccatc aggggccccg                                                   20


<210> 17127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17127
cattgccagc actccatcag                                                   20


<210> 17128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17128
ccattgccag cactccatca                                                   20


<210> 17129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17129
gccattgcca gcactccatc                                                   20


<210> 17130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17130
ggccattgcc agcactccat                                                   20


<210> 17131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17131
acggtgtctc gggccattgc                                                   20


<210> 17132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17132
gggtgtaatt acggtgtctc                                                   20


<210> 17133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17133
tgggtgtaat tacggtgtct                                                   20


<210> 17134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17134
agtcgttatg ggtgtaatta                                                   20


<210> 17135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17135
tgaatgctga gagtcgttat                                                   20


<210> 17136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17136
gtgaatgctg agagtcgtta                                                   20


<210> 17137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17137
tcaagcccag tgaatgctga                                                   20


<210> 17138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17138
attcaagccc agtgaatgct                                                   20


<210> 17139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17139
catgattaaa tattcaagcc                                                   20


<210> 17140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17140
tactccatga ttaaatattc                                                   20


<210> 17141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17141
aggagggcag caggcccctg                                                   20


<210> 17142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17142
ggagctgcca ggagggcagc                                                   20


<210> 17143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17143
tggagctgcc aggagggcag                                                   20


<210> 17144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17144
ggctggagct gccaggaggg                                                   20


<210> 17145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17145
tagggctgga gctgccagga                                                   20


<210> 17146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17146
atagggctgg agctgccagg                                                   20


<210> 17147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17147
tatagggctg gagctgccag                                                   20


<210> 17148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17148
attatagggc tggagctgcc                                                   20


<210> 17149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17149
cattataggg ctggagctgc                                                   20


<210> 17150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17150
ctggagacat tatagggctg                                                   20


<210> 17151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17151
atctggagac attatagggc                                                   20


<210> 17152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17152
attcatctgg agacattata                                                   20


<210> 17153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17153
aattcatctg gagacattat                                                   20


<210> 17154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17154
gaattcatct ggagacatta                                                   20


<210> 17155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17155
cccctaattg aattcatctg                                                   20


<210> 17156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17156
aacccctaat tgaattcatc                                                   20


<210> 17157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17157
tatcaggttt actaatatga                                                   20


<210> 17158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17158
gctatcaggt ttactaatat                                                   20


<210> 17159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17159
ggtccattag caaagctatc                                                   20


<210> 17160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17160
gggtccatta gcaaagctat                                                   20


<210> 17161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17161
accatttggg tccattagca                                                   20


<210> 17162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17162
gccccaccat ttgggtccat                                                   20


<210> 17163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17163
ggggacccgc cccaccattt                                                   20


<210> 17164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17164
tggggacccg ccccaccatt                                                   20


<210> 17165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17165
gggcctgaca gcgacaaatg                                                   20


<210> 17166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17166
ggggcctgac agcgacaaat                                                   20


<210> 17167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17167
aggggcctga cagcgacaaa                                                   20


<210> 17168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17168
gctaggcagg aggggcctga                                                   20


<210> 17169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17169
tgaccccggc taggcaggag                                                   20


<210> 17170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17170
atgaccccgg ctaggcagga                                                   20


<210> 17171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17171
catgaccccg gctaggcagg                                                   20


<210> 17172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17172
ccatgacccc ggctaggcag                                                   20


<210> 17173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17173
gtccatgacc ccggctaggc                                                   20


<210> 17174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17174
tgtccatgac cccggctagg                                                   20


<210> 17175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17175
tcttgtccat gaccccggct                                                   20


<210> 17176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17176
ttcttgtcca tgaccccggc                                                   20


<210> 17177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17177
tgttttcttg tccatgaccc                                                   20


<210> 17178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17178
agtacacaac ttctgggtgt                                                   20


<210> 17179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17179
gttttcagta cacaacttct                                                   20


<210> 17180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17180
tgttttcagt acacaacttc                                                   20


<210> 17181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17181
ttgtccctac tcaatgtttt                                                   20


<210> 17182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17182
gttccaagga ctcccctggc                                                   20


<210> 17183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17183
aaatgttcca aggactcccc                                                   20


<210> 17184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17184
gcttcttccc aaatgttcca                                                   20


<210> 17185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17185
tgcttcttcc caaatgttcc                                                   20


<210> 17186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17186
gggctgtcac attctgcacg                                                   20


<210> 17187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17187
gcttggttcc cactgggtga                                                   20


<210> 17188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17188
cgcttggttc ccactgggtg                                                   20


<210> 17189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17189
ccgcttggtt cccactgggt                                                   20


<210> 17190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17190
gaagccgctt ggttcccact                                                   20


<210> 17191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17191
agaagccgct tggttcccac                                                   20


<210> 17192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17192
gtgggtgaac agaagccgct                                                   20


<210> 17193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17193
tgggggctgt gggtgaacag                                                   20


<210> 17194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17194
atttgggggc tgtgggtgaa                                                   20


<210> 17195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17195
ggacgggatt tgggggctgt                                                   20


<210> 17196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17196
gggacgggat ttgggggctg                                                   20


<210> 17197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17197
agggctggga cgggatttgg                                                   20


<210> 17198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17198
gagggctggg acgggatttg                                                   20


<210> 17199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17199
ggagggctgg gacgggattt                                                   20


<210> 17200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17200
gggagggctg ggacgggatt                                                   20


<210> 17201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17201
ataagaggga gggctgggac                                                   20


<210> 17202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17202
gataagaggg agggctggga                                                   20


<210> 17203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17203
gtaagataag agggagggct                                                   20


<210> 17204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17204
ggtaagataa gagggagggc                                                   20


<210> 17205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17205
gcagggtaag ataagaggga                                                   20


<210> 17206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17206
agcagggtaa gataagaggg                                                   20


<210> 17207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17207
cagcagggta agataagagg                                                   20


<210> 17208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17208
cacagcaggg taagataaga                                                   20


<210> 17209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17209
ccacagcagg gtaagataag                                                   20


<210> 17210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17210
accacagcag ggtaagataa                                                   20


<210> 17211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17211
tgaccacagc agggtaagat                                                   20


<210> 17212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17212
aaggctgacc acagcagggt                                                   20


<210> 17213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17213
aggcaaggct gaccacagca                                                   20


<210> 17214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17214
taggcaaggc tgaccacagc                                                   20


<210> 17215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17215
ctaggcaagg ctgaccacag                                                   20


<210> 17216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17216
gccctaggca aggctgacca                                                   20


<210> 17217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17217
ctggctgtgt gccctaggca                                                   20


<210> 17218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17218
actggctgtg tgccctaggc                                                   20


<210> 17219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17219
agctactggc tgtgtgccct                                                   20


<210> 17220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17220
cagctactgg ctgtgtgccc                                                   20


<210> 17221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17221
gcttgaagaa tgtcagctac                                                   20


<210> 17222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17222
cccttcagct tgaagaatgt                                                   20


<210> 17223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17223
ttatcaagcc cttcagcttg                                                   20


<210> 17224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17224
cccaaagtta tcaagccctt                                                   20


<210> 17225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17225
aattcatccc caaagttatc                                                   20


<210> 17226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17226
gaagtcataa ttcatcccca                                                   20


<210> 17227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17227
tgggctcaac agagataagg                                                   20


<210> 17228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17228
cactgggctc aacagagata                                                   20


<210> 17229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17229
gcactgggct caacagagat                                                   20


<210> 17230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17230
gacaggcact gggctcaaca                                                   20


<210> 17231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17231
gtgacaggca ctgggctcaa                                                   20


<210> 17232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17232
ctgactttgt gacaggcact                                                   20


<210> 17233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17233
gctgactttg tgacaggcac                                                   20


<210> 17234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17234
ctgagtgctg actttgtgac                                                   20


<210> 17235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17235
actgagtgct gactttgtga                                                   20


<210> 17236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17236
taatttgaca cctagccact                                                   20


<210> 17237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17237
caagaattta atttgacacc                                                   20


<210> 17238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17238
aataacactg ccttcaattc                                                   20


<210> 17239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17239
aagaggcatc tataaaagtt                                                   20


<210> 17240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17240
agggaaagag gcatctataa                                                   20


<210> 17241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17241
gaaacaagct atagggaaag                                                   20


<210> 17242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17242
ggaaacaagc tatagggaaa                                                   20


<210> 17243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17243
aaggaaacaa gctataggga                                                   20


<210> 17244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17244
cttgaaggaa acaagctata                                                   20


<210> 17245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17245
tcttgaagga aacaagctat                                                   20


<210> 17246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17246
atcttgaagg aaacaagcta                                                   20


<210> 17247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17247
ttacaaatct tgaaggaaac                                                   20


<210> 17248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17248
gtttcactta caaatcttga                                                   20


<210> 17249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17249
ggtttcactt acaaatcttg                                                   20


<210> 17250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17250
atacaaggta aaaataaatg                                                   20


<210> 17251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17251
gtttaggatt gtcttataca                                                   20


<210> 17252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17252
ggtttaggat tgtcttatac                                                   20


<210> 17253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17253
agctggaaga ttagaggttt                                                   20


<210> 17254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17254
gagctggaag attagaggtt                                                   20


<210> 17255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17255
agactgagct ggaagattag                                                   20


<210> 17256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17256
gagactgagc tggaagatta                                                   20


<210> 17257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17257
cagagactga gctggaagat                                                   20


<210> 17258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17258
cctcacagag actgagctgg                                                   20


<210> 17259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17259
cagcctcaca gagactgagc                                                   20


<210> 17260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17260
gtgacagcct cacagagact                                                   20


<210> 17261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17261
agtgaagtga cagcctcaca                                                   20


<210> 17262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17262
gtagtgaagt gacagcctca                                                   20


<210> 17263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17263
ataggtgagt agtgaagtga                                                   20


<210> 17264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17264
ctctctatag gtgagtagtg                                                   20


<210> 17265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17265
agaggctctc tataggtgag                                                   20


<210> 17266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17266
gggagaggct ctctataggt                                                   20


<210> 17267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17267
gctagggaga ggctctctat                                                   20


<210> 17268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17268
ggctagggag aggctctcta                                                   20


<210> 17269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17269
agtagcctgg ggctagggag                                                   20


<210> 17270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17270
aagtagcctg gggctaggga                                                   20


<210> 17271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17271
aaaagtagcc tggggctagg                                                   20


<210> 17272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17272
gcaaaagtag cctggggcta                                                   20


<210> 17273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17273
ggcaaaagta gcctggggct                                                   20


<210> 17274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17274
aggcaaaagt agcctggggc                                                   20


<210> 17275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17275
ctctaggcaa aagtagcctg                                                   20


<210> 17276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17276
tctctaggca aaagtagcct                                                   20


<210> 17277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17277
ttctctaggc aaaagtagcc                                                   20


<210> 17278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17278
tcattttctc taggcaaaag                                                   20


<210> 17279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17279
acatcatttt ctctaggcaa                                                   20


<210> 17280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17280
ttgtccacat cattttctct                                                   20


<210> 17281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17281
tttgtccaca tcattttctc                                                   20


<210> 17282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17282
ggaggtgctc acagatgaag                                                   20


<210> 17283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17283
gttggaggtg ctcacagatg                                                   20


<210> 17284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17284
ataagagttg gaggtgctca                                                   20


<210> 17285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17285
agccagcaaa taagagttgg                                                   20


<210> 17286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17286
gagccagcaa ataagagttg                                                   20


<210> 17287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17287
cagagccagc aaataagagt                                                   20


<210> 17288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17288
ctttcagagc cagcaaataa                                                   20


<210> 17289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17289
atctttcaga gccagcaaat                                                   20


<210> 17290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17290
agtcaaatat ctttcagagc                                                   20


<210> 17291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17291
agaaagtcaa atatctttca                                                   20


<210> 17292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17292
aaagaaagtc aaatatcttt                                                   20


<210> 17293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17293
cgaaagacaa cgcacaaaga                                                   20


<210> 17294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17294
gaaacgaaag acaacgcaca                                                   20


<210> 17295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17295
gccaagaaaa aaggaaacga                                                   20


<210> 17296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17296
gaaatgacag ccaagaaaaa                                                   20


<210> 17297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17297
ggaaatgaca gccaagaaaa                                                   20


<210> 17298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17298
gtgcccagga aatgacagcc                                                   20


<210> 17299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17299
agtaagtgcc caggaaatga                                                   20


<210> 17300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17300
ctgagacaaa gtaagtgccc                                                   20


<210> 17301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17301
cctgagacaa agtaagtgcc                                                   20


<210> 17302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17302
ggtcctgcct gagacaaagt                                                   20


<210> 17303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17303
tttaggtcct gcctgagaca                                                   20


<210> 17304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17304
caaatgttta ggtcctgcct                                                   20


<210> 17305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17305
atgctgcttg tcaaatgttt                                                   20


<210> 17306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17306
gatgctgctt gtcaaatgtt                                                   20


<210> 17307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17307
gattattttg aagcttaaat                                                   20


<210> 17308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17308
tacttggtag gattattttg                                                   20


<210> 17309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17309
aatggtaatg cctacttggt                                                   20


<210> 17310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17310
gaatggtaat gcctacttgg                                                   20


<210> 17311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17311
actgaatggt aatgcctact                                                   20


<210> 17312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17312
tattcatcta tgaaactgaa                                                   20


<210> 17313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17313
atcagttccc aaacctctct                                                   20


<210> 17314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17314
caagctgtgg gacctaagat                                                   20


<210> 17315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17315
ctccacaagc tgtgggacct                                                   20


<210> 17316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17316
agtgagactc cacaagctgt                                                   20


<210> 17317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17317
gagtgagact ccacaagctg                                                   20


<210> 17318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17318
aagaaagagt gagactccac                                                   20


<210> 17319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17319
taggtataga aagaaagagt                                                   20


<210> 17320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17320
gttctaggta tagaaagaaa                                                   20


<210> 17321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17321
tggttctagg tatagaaaga                                                   20


<210> 17322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17322
agggtggttc taggtataga                                                   20


<210> 17323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17323
ctccagggtg gttctaggta                                                   20


<210> 17324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17324
tctcactcca gggtggttct                                                   20


<210> 17325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17325
atctcactcc agggtggttc                                                   20


<210> 17326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17326
gccacaatct cactccaggg                                                   20


<210> 17327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17327
attgccacaa tctcactcca                                                   20


<210> 17328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17328
cattgccaca atctcactcc                                                   20


<210> 17329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17329
ccattgccac aatctcactc                                                   20


<210> 17330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17330
ttaaagtccc tcccaacctc                                                   20


<210> 17331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17331
tcttatcctg ggaattttta                                                   20


<210> 17332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17332
ataacctcat ttcttatcct                                                   20


<210> 17333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17333
cataacctca tttcttatcc                                                   20


<210> 17334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17334
gcggtgaagg tggggtattc                                                   20


<210> 17335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17335
ggagggtggc ggtgaaggtg                                                   20


<210> 17336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17336
tggagggtgg cggtgaaggt                                                   20


<210> 17337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17337
ctggagggtg gcggtgaagg                                                   20


<210> 17338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17338
aggctggagg gtggcggtga                                                   20


<210> 17339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17339
gaggctggag ggtggcggtg                                                   20


<210> 17340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17340
tggtagaggc tggagggtgg                                                   20


<210> 17341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17341
ggctggtaga ggctggaggg                                                   20


<210> 17342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17342
gtgggctggt agaggctgga                                                   20


<210> 17343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17343
agtgggctgg tagaggctgg                                                   20


<210> 17344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17344
cagtgggctg gtagaggctg                                                   20


<210> 17345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17345
agcagtgggc tggtagaggc                                                   20


<210> 17346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17346
actgagcagt gggctggtag                                                   20


<210> 17347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17347
cactgagcag tgggctggta                                                   20


<210> 17348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17348
gacactgagc agtgggctgg                                                   20


<210> 17349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17349
ccagacactg agcagtgggc                                                   20


<210> 17350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17350
ccagccagac actgagcagt                                                   20


<210> 17351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17351
gccagccaga cactgagcag                                                   20


<210> 17352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17352
acagccagcc agacactgag                                                   20


<210> 17353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17353
tggacagcca gccagacact                                                   20


<210> 17354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17354
ggagaggttg gacagccagc                                                   20


<210> 17355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17355
tcctggagag gttggacagc                                                   20


<210> 17356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17356
agcttcctgg agaggttgga                                                   20


<210> 17357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17357
tgtcagcttc ctggagaggt                                                   20


<210> 17358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17358
ggtatgtcag cttcctggag                                                   20


<210> 17359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17359
aggtatgtca gcttcctgga                                                   20


<210> 17360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17360
gtaggtatgt cagcttcctg                                                   20


<210> 17361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17361
aggtaggtat gtcagcttcc                                                   20


<210> 17362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17362
ccctgctgag gtaggtatgt                                                   20


<210> 17363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17363
cctcaggtcc ctgctgaggt                                                   20


<210> 17364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17364
tcctcaggtc cctgctgagg                                                   20


<210> 17365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17365
tgttcctcag gtccctgctg                                                   20


<210> 17366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17366
ctgttcctca ggtccctgct                                                   20


<210> 17367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17367
gaaagatgag tctgttcctc                                                   20


<210> 17368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17368
ggaaagatga gtctgttcct                                                   20


<210> 17369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17369
tgggtgagac gtggaaagat                                                   20


<210> 17370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17370
atccctgggt gagacgtgga                                                   20


<210> 17371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17371
ctccatccct gggtgagacg                                                   20


<210> 17372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17372
acctggctcc atccctgggt                                                   20


<210> 17373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17373
gaggacctgg ctccatccct                                                   20


<210> 17374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17374
tgaggacctg gctccatccc                                                   20


<210> 17375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17375
tggaacatct tctgaggacc                                                   20


<210> 17376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17376
aggcactgga acatcttctg                                                   20


<210> 17377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17377
caggcactgg aacatcttct                                                   20


<210> 17378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17378
acacccagga gcccaggcac                                                   20


<210> 17379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17379
cacctgacac ccaggagccc                                                   20


<210> 17380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17380
ccacctgaca cccaggagcc                                                   20


<210> 17381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17381
ggggaccacc tgacacccag                                                   20


<210> 17382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17382
gtggggacca cctgacaccc                                                   20


<210> 17383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17383
tgtggggacc acctgacacc                                                   20


<210> 17384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17384
gcagcaagtc gagaggtgtg                                                   20


<210> 17385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17385
tgcagcaagt cgagaggtgt                                                   20


<210> 17386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17386
ctgcagcaag tcgagaggtg                                                   20


<210> 17387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17387
agcagctgca gcaagtcgag                                                   20


<210> 17388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17388
gagcagctgc agcaagtcga                                                   20


<210> 17389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17389
aggagcagct gcagcaagtc                                                   20


<210> 17390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17390
ctagcaggag cagctgcagc                                                   20


<210> 17391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17391
ctcactagca ggagcagctg                                                   20


<210> 17392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17392
ccctctctca ctagcaggag                                                   20


<210> 17393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17393
ggaccctctc tcactagcag                                                   20


<210> 17394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17394
tgggaccctc tctcactagc                                                   20


<210> 17395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17395
ttgggaccct ctctcactag                                                   20


<210> 17396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17396
cagttgggac cctctctcac                                                   20


<210> 17397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17397
gtggggccag gcacccagtt                                                   20


<210> 17398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17398
ggtggggcca ggcacccagt                                                   20


<210> 17399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17399
taagggtggg gccaggcacc                                                   20


<210> 17400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17400
ggtcatctaa gggtggggcc                                                   20


<210> 17401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17401
tggtcatcta agggtggggc                                                   20


<210> 17402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17402
gaactggtca tctaagggtg                                                   20


<210> 17403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17403
agaactggtc atctaagggt                                                   20


<210> 17404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17404
tagaactggt catctaaggg                                                   20


<210> 17405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17405
atttagaact ggtcatctaa                                                   20


<210> 17406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17406
aatttagaac tggtcatcta                                                   20


<210> 17407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17407
aaatttagaa ctggtcatct                                                   20


<210> 17408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17408
gatcccttca aatttagaac                                                   20


<210> 17409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17409
gtgcaagatc ccttcaaatt                                                   20


<210> 17410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17410
tctggcagcc tgtgatgtgc                                                   20


<210> 17411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17411
tatgaaactc ttggctctgg                                                   20


<210> 17412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17412
atatatgaaa ctcttggctc                                                   20


<210> 17413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17413
agttgcatat atgaaactct                                                   20


<210> 17414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17414
atgtatatat gtatgtacat                                                   20


<210> 17415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17415
aacataggtc tatctagcta                                                   20


<210> 17416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17416
ggataaaaca taggtctatc                                                   20


<210> 17417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17417
ggagcccaag gataaaacat                                                   20


<210> 17418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17418
tggagcccaa ggataaaaca                                                   20


<210> 17419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17419
cttataatta atggagccca                                                   20


<210> 17420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17420
tcttataatt aatggagccc                                                   20


<210> 17421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17421
cacacatctt ataattaatg                                                   20


<210> 17422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17422
gtcacacatc ttataattaa                                                   20


<210> 17423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17423
gaggttaaac aacttgccta                                                   20


<210> 17424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17424
agaggttaaa caacttgcct                                                   20


<210> 17425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17425
gggaaaaatg aagattagag                                                   20


<210> 17426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17426
tgggaaaaat gaagattaga                                                   20


<210> 17427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17427
gctgggaaaa atgaagatta                                                   20


<210> 17428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17428
aagctgggaa aaatgaagat                                                   20


<210> 17429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17429
ttttgaagct gggaaaaatg                                                   20


<210> 17430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17430
gccttttcaa ttttgaagct                                                   20


<210> 17431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17431
agccttttca attttgaagc                                                   20


<210> 17432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17432
atctagcctt ttcaattttg                                                   20


<210> 17433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17433
acagctgaat gatgcagatc                                                   20


<210> 17434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17434
atcaaaacag ctgaatgatg                                                   20


<210> 17435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17435
aacatattta gtcatcaaaa                                                   20


<210> 17436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17436
tttacaagcg ctaacatatt                                                   20


<210> 17437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17437
cttcgtgcaa agtgttttac                                                   20


<210> 17438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17438
tgagccaagc acttcgtgca                                                   20


<210> 17439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17439
tggctaaaat ctattgagcc                                                   20


<210> 17440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17440
ggtcatggct aaaatctatt                                                   20


<210> 17441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17441
tggacaaata acaatggtca                                                   20


<210> 17442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17442
gacctctgga caaataacaa                                                   20


<210> 17443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17443
ttccctacaa ttttgacctc                                                   20


<210> 17444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17444
ttagggagct ccaggtggcc                                                   20


<210> 17445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17445
ggctcttagg gagctccagg                                                   20


<210> 17446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17446
tggggctctt agggagctcc                                                   20


<210> 17447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17447
ttggggctct tagggagctc                                                   20


<210> 17448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17448
gttactttgg ggctcttagg                                                   20


<210> 17449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17449
cagttacttt ggggctctta                                                   20


<210> 17450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17450
tcagttactt tggggctctt                                                   20


<210> 17451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17451
ttcagttact ttggggctct                                                   20


<210> 17452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17452
aagcattttc agttactttg                                                   20


<210> 17453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17453
gaagcatttt cagttacttt                                                   20


<210> 17454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17454
agaagcattt tcagttactt                                                   20


<210> 17455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17455
ctgccactca gaagcatttt                                                   20


<210> 17456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17456
gacagctgtc tgccactcag                                                   20


<210> 17457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17457
tgtgacagct gtctgccact                                                   20


<210> 17458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17458
agagagcatg aactctgtga                                                   20


<210> 17459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17459
tttgtctagg taacagcaga                                                   20


<210> 17460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17460
cctttgtcta ggtaacagca                                                   20


<210> 17461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17461
tgcctttgtc taggtaacag                                                   20


<210> 17462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17462
acatgccttt gtctaggtaa                                                   20


<210> 17463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17463
tattttacat gcctttgtct                                                   20


<210> 17464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17464
atattttaca tgcctttgtc                                                   20


<210> 17465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17465
gttccagcag ctgctgttat                                                   20


<210> 17466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17466
agtcgtcact tgtgttccag                                                   20


<210> 17467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17467
tgcagtcgtc acttgtgttc                                                   20


<210> 17468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17468
tcccatagcc ttcttccctg                                                   20


<210> 17469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17469
ttgagtctgt agctctccca                                                   20


<210> 17470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17470
aaagctgtgc tttgagtctg                                                   20


<210> 17471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17471
gtccagaaaa gctgtgcttt                                                   20


<210> 17472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17472
ggttactaag tggtccagaa                                                   20


<210> 17473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17473
ggccaggtta ctaagtggtc                                                   20


<210> 17474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17474
ctgctggcca ggttactaag                                                   20


<210> 17475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17475
gggctgctgg ccaggttact                                                   20


<210> 17476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17476
aacatgcagg gctgctggcc                                                   20


<210> 17477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17477
gaacatgcag ggctgctggc                                                   20


<210> 17478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17478
tcaggaacat gcagggctgc                                                   20


<210> 17479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17479
tgaggcctca ggaacatgca                                                   20


<210> 17480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17480
gtgaggcctc aggaacatgc                                                   20


<210> 17481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17481
tgtgaggcct caggaacatg                                                   20


<210> 17482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17482
agggaaccct gtgaggcctc                                                   20


<210> 17483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17483
cagggaaccc tgtgaggcct                                                   20


<210> 17484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17484
ggaaggcagg gaaccctgtg                                                   20


<210> 17485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17485
gggaaggcag ggaaccctgt                                                   20


<210> 17486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17486
ctgcccaacg tgggaaggca                                                   20


<210> 17487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17487
tctgcccaac gtgggaaggc                                                   20


<210> 17488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17488
ctctgcccaa cgtgggaagg                                                   20


<210> 17489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17489
cacctctgcc caacgtggga                                                   20


<210> 17490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17490
tcacctctgc ccaacgtggg                                                   20


<210> 17491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17491
cattcacctc tgcccaacgt                                                   20


<210> 17492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17492
gcattcacct ctgcccaacg                                                   20


<210> 17493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17493
aacctcttct cagtaactca                                                   20


<210> 17494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17494
taacctcttc tcagtaactc                                                   20


<210> 17495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17495
ctaacctctt ctcagtaact                                                   20


<210> 17496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17496
aaccctcgct aacctcttct                                                   20


<210> 17497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17497
tattccttac taccttaagc                                                   20


<210> 17498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17498
gcactattcc ttactacctt                                                   20


<210> 17499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17499
aatatatatt tttaaatact                                                   20


<210> 17500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17500
aactaattta aagcacattt                                                   20


<210> 17501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17501
ttttggcacc aactaattta                                                   20


<210> 17502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17502
gggaaatgac acgctccttt                                                   20


<210> 17503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17503
tccccacaag tggtatcaca                                                   20


<210> 17504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17504
ttccccacaa gtggtatcac                                                   20


<210> 17505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17505
tttccccaca agtggtatca                                                   20


<210> 17506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17506
agccagcttt tccccacaag                                                   20


<210> 17507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17507
tttagccagc ttttccccac                                                   20


<210> 17508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17508
tcttatgtga ctcatttagc                                                   20


<210> 17509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17509
tgattcttat gtgactcatt                                                   20


<210> 17510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17510
atctttacca gcatcctaag                                                   20


<210> 17511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17511
ctaatcttta ccagcatcct                                                   20


<210> 17512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17512
aaggctcatc taatctttac                                                   20


<210> 17513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17513
caggatgttg tccaagagca                                                   20


<210> 17514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17514
acaggatgtt gtccaagagc                                                   20


<210> 17515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17515
aagaacagga tgttgtccaa                                                   20


<210> 17516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17516
ctaagaacag gatgttgtcc                                                   20


<210> 17517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17517
aatgagattt ctctaagaac                                                   20


<210> 17518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17518
taatgagatt tctctaagaa                                                   20


<210> 17519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17519
gatgctaatg agatttctct                                                   20


<210> 17520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17520
tctgtgcatg agatgctaat                                                   20


<210> 17521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17521
ccaacccagg ctctgtgcat                                                   20


<210> 17522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17522
ccatgcgctc tgcccaaccc                                                   20


<210> 17523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17523
cccatgcgct ctgcccaacc                                                   20


<210> 17524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17524
cttggggatt gtctttcaca                                                   20


<210> 17525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17525
aggccacctt gaggtgcttg                                                   20


<210> 17526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17526
aaggccacct tgaggtgctt                                                   20


<210> 17527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17527
aaaggccacc ttgaggtgct                                                   20


<210> 17528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17528
gtgagcaaaa ggccaccttg                                                   20


<210> 17529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17529
ggtgagcaaa aggccacctt                                                   20


<210> 17530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17530
gggggcagca ggtgagcaaa                                                   20


<210> 17531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17531
ggggggcagc aggtgagcaa                                                   20


<210> 17532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17532
gggagtgggg ggcagcaggt                                                   20


<210> 17533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17533
aacagggagt ggggggcagc                                                   20


<210> 17534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17534
aaacagggag tggggggcag                                                   20


<210> 17535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17535
gacaaacagg gagtgggggg                                                   20


<210> 17536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17536
gcagacaaac agggagtggg                                                   20


<210> 17537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17537
ggcagacaaa cagggagtgg                                                   20


<210> 17538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17538
aggcagacaa acagggagtg                                                   20


<210> 17539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17539
caggcagaca aacagggagt                                                   20


<210> 17540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17540
ccaggcagac aaacagggag                                                   20


<210> 17541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17541
tccccaggca gacaaacagg                                                   20


<210> 17542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17542
attccccagg cagacaaaca                                                   20


<210> 17543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17543
aattccccag gcagacaaac                                                   20


<210> 17544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17544
gaattcccca ggcagacaaa                                                   20


<210> 17545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17545
aaaagtcaga attccccagg                                                   20


<210> 17546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17546
agaaaaagtc agaattcccc                                                   20


<210> 17547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17547
aagaaaaagt cagaattccc                                                   20


<210> 17548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17548
cagggcctgg aagaaaaagt                                                   20


<210> 17549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17549
tgagcagggc ctggaagaaa                                                   20


<210> 17550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17550
ggcgtttgag cagggcctgg                                                   20


<210> 17551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17551
gttggcgttt gagcagggcc                                                   20


<210> 17552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17552
gaggagttgg cgtttgagca                                                   20


<210> 17553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17553
agaggagttg gcgtttgagc                                                   20


<210> 17554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17554
cagaggagtt ggcgtttgag                                                   20


<210> 17555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17555
ttccagagga gttggcgttt                                                   20


<210> 17556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17556
gccaagcttt ccagaggagt                                                   20


<210> 17557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17557
ccatgccaag ctttccagag                                                   20


<210> 17558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17558
aaccatgcca agctttccag                                                   20


<210> 17559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17559
aaaccatgcc aagctttcca                                                   20


<210> 17560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17560
ttaaaccatg ccaagctttc                                                   20


<210> 17561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17561
aaagaagttt aaaccatgcc                                                   20


<210> 17562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17562
gaggagacct tgacataaag                                                   20


<210> 17563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17563
gcagaggaga ccttgacata                                                   20


<210> 17564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17564
ggcaaaaggg aaatgcagag                                                   20


<210> 17565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17565
agggcaaaag ggaaatgcag                                                   20


<210> 17566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17566
aagggcaaaa gggaaatgca                                                   20


<210> 17567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17567
caaagggcaa aagggaaatg                                                   20


<210> 17568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17568
ttgagtgaca aagggcaaaa                                                   20


<210> 17569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17569
cttgagtgac aaagggcaaa                                                   20


<210> 17570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17570
gcttgagtga caaagggcaa                                                   20


<210> 17571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17571
ttcagggctt gagtgacaaa                                                   20


<210> 17572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17572
cttcagggct tgagtgacaa                                                   20


<210> 17573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17573
gcttcagggc ttgagtgaca                                                   20


<210> 17574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17574
ggggaggggc ttcagggctt                                                   20


<210> 17575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17575
ggcagtgggg aggggcttca                                                   20


<210> 17576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17576
aggcagtggg gaggggcttc                                                   20


<210> 17577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17577
caggcagtgg ggaggggctt                                                   20


<210> 17578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17578
cagccacagg cagtggggag                                                   20


<210> 17579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17579
acagccacag gcagtgggga                                                   20


<210> 17580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17580
gacagccaca ggcagtgggg                                                   20


<210> 17581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17581
ggacagccac aggcagtggg                                                   20


<210> 17582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17582
agggacagcc acaggcagtg                                                   20


<210> 17583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17583
aagggacagc cacaggcagt                                                   20


<210> 17584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17584
caagggacag ccacaggcag                                                   20


<210> 17585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17585
ccccaaggga cagccacagg                                                   20


<210> 17586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17586
tatccccaag ggacagccac                                                   20


<210> 17587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17587
ttatccccaa gggacagcca                                                   20


<210> 17588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17588
taagagttat ccccaaggga                                                   20


<210> 17589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17589
caggtaagag ttatccccaa                                                   20


<210> 17590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17590
acaggtaaga gttatcccca                                                   20


<210> 17591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17591
gacaggtaag agttatcccc                                                   20


<210> 17592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17592
gatccccaaa ggacaggtaa                                                   20


<210> 17593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17593
gtgatcccca aaggacaggt                                                   20


<210> 17594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17594
ggaagtgatc cccaaaggac                                                   20


<210> 17595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17595
aggaagtgat ccccaaagga                                                   20


<210> 17596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17596
cagcaggaag tgatccccaa                                                   20


<210> 17597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17597
ccagcaggaa gtgatcccca                                                   20


<210> 17598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17598
tgctcagagc ttccagcagg                                                   20


<210> 17599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17599
agatgctcag agcttccagc                                                   20


<210> 17600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17600
aagatgctca gagcttccag                                                   20


<210> 17601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17601
gggaagatgc tcagagcttc                                                   20


<210> 17602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17602
gatggtgggg aagatgctca                                                   20


<210> 17603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17603
atgatggtgg ggaagatgct                                                   20


<210> 17604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17604
cttggaggat gatggtgggg                                                   20


<210> 17605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17605
tgacttggag gatgatggtg                                                   20


<210> 17606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17606
atgacttgga ggatgatggt                                                   20


<210> 17607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17607
gatgacttgg aggatgatgg                                                   20


<210> 17608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17608
cttgatgact tggaggatga                                                   20


<210> 17609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17609
atctgatctt gatgacttgg                                                   20


<210> 17610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17610
aatctgatct tgatgacttg                                                   20


<210> 17611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17611
tgaatctgat cttgatgact                                                   20


<210> 17612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17612
gtctctgtgc ccattgctga                                                   20


<210> 17613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17613
ggtctctgtg cccattgctg                                                   20


<210> 17614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17614
gggtctctgt gcccattgct                                                   20


<210> 17615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17615
catcgctaat ccgactgtgt                                                   20


<210> 17616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17616
tcatcgctaa tccgactgtg                                                   20


<210> 17617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17617
agaggcccca gggatgagca                                                   20


<210> 17618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17618
ctcccagagg ccccagggat                                                   20


<210> 17619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17619
ccaagctccc agaggcccca                                                   20


<210> 17620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17620
tccaagctcc cagaggcccc                                                   20


<210> 17621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17621
ctccaagctc ccagaggccc                                                   20


<210> 17622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17622
ggagggctcc aagctcccag                                                   20


<210> 17623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17623
tggagggctc caagctccca                                                   20


<210> 17624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17624
tctggagggc tccaagctcc                                                   20


<210> 17625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17625
ggggagctct ggagggctcc                                                   20


<210> 17626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17626
ctgccagggg gagctctgga                                                   20


<210> 17627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17627
actgccaggg ggagctctgg                                                   20


<210> 17628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17628
cactgccagg gggagctctg                                                   20


<210> 17629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17629
aacactgcca gggggagctc                                                   20


<210> 17630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17630
gctgccaaca ctgccagggg                                                   20


<210> 17631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17631
ttgctgccaa cactgccagg                                                   20


<210> 17632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17632
attgctgcca acactgccag                                                   20


<210> 17633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17633
cattgctgcc aacactgcca                                                   20


<210> 17634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17634
acattgctgc caacactgcc                                                   20


<210> 17635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17635
cacattgctg ccaacactgc                                                   20


<210> 17636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17636
cactctccag ctccaaggct                                                   20


<210> 17637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17637
actcccactc tccagctcca                                                   20


<210> 17638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17638
aactcccact ctccagctcc                                                   20


<210> 17639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17639
gtggtgaaac tcccactctc                                                   20


<210> 17640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17640
caaggcagag cctgagctgg                                                   20


<210> 17641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17641
gcccaaggca gagcctgagc                                                   20


<210> 17642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17642
cccagcccaa ggcagagcct                                                   20


<210> 17643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17643
cattccccca gcccaaggca                                                   20


<210> 17644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17644
cccattcccc cagcccaagg                                                   20


<210> 17645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17645
ctgcccattc ccccagccca                                                   20


<210> 17646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17646
cctgcccatt cccccagccc                                                   20


<210> 17647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17647
gcaggtcctg cccattcccc                                                   20


<210> 17648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17648
ctctttgcag cttcttcagc                                                   20


<210> 17649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17649
gctctttgca gcttcttcag                                                   20


<210> 17650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17650
caggctcttt gcagcttctt                                                   20


<210> 17651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17651
cgtaccaaac aggctctttg                                                   20


<210> 17652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17652
ctttggccat cgtaccaaac                                                   20


<210> 17653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17653
tctttggcca tcgtaccaaa                                                   20


<210> 17654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17654
ctggcacgga tccaggtctt                                                   20


<210> 17655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17655
ggtggccctg gcacggatcc                                                   20


<210> 17656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17656
aggtggccct ggcacggatc                                                   20


<210> 17657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17657
acctgcaggt ggccctggca                                                   20


<210> 17658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17658
gaacaacctg caggtggccc                                                   20


<210> 17659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17659
ggaggtgaac aacctgcagg                                                   20


<210> 17660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17660
tggggaggtg aacaacctgc                                                   20


<210> 17661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17661
atggggaggt gaacaacctg                                                   20


<210> 17662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17662
agccccggag gacgatgggg                                                   20


<210> 17663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17663
cagccccgga ggacgatggg                                                   20


<210> 17664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17664
cacagccccg gaggacgatg                                                   20


<210> 17665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17665
tcacagcccc ggaggacgat                                                   20


<210> 17666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17666
ctcacagccc cggaggacga                                                   20


<210> 17667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17667
tgacaacctc acagccccgg                                                   20


<210> 17668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17668
ctgacaacct cacagccccg                                                   20


<210> 17669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17669
tgctgacaac ctcacagccc                                                   20


<210> 17670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17670
tttcagtgct gacaacctca                                                   20


<210> 17671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17671
gccctgctat tgaactcttt                                                   20


<210> 17672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17672
cccttccatt ccttctcttc                                                   20


<210> 17673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17673
tcccttccat tccttctctt                                                   20


<210> 17674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17674
ccaatgtggg gctcagctta                                                   20


<210> 17675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17675
ggccaatgtg gggctcagct                                                   20


<210> 17676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17676
cggtaggcca atgtggggct                                                   20


<210> 17677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17677
taacccggta ggccaatgtg                                                   20


<210> 17678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17678
ctaacccggt aggccaatgt                                                   20


<210> 17679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17679
gctaacccgg taggccaatg                                                   20


<210> 17680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17680
cagccagctg ctaacccggt                                                   20


<210> 17681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17681
ccagccagct gctaacccgg                                                   20


<210> 17682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17682
ttgccagcca gctgctaacc                                                   20


<210> 17683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17683
gccgtggctg tcttgccagc                                                   20


<210> 17684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17684
ccaggccgtg gctgtcttgc                                                   20


<210> 17685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17685
gcaggaagag gcccaggccg                                                   20


<210> 17686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17686
gggtgggcag gaagaggccc                                                   20


<210> 17687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17687
cgggtgggca ggaagaggcc                                                   20


<210> 17688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17688
catcccgggt gggcaggaag                                                   20


<210> 17689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17689
gcatcccggg tgggcaggaa                                                   20


<210> 17690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17690
cagcatcccg ggtgggcagg                                                   20


<210> 17691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17691
ggacagcatc ccgggtgggc                                                   20


<210> 17692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17692
gggacagcat cccgggtggg                                                   20


<210> 17693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17693
aaagggacag catcccgggt                                                   20


<210> 17694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17694
aaaagggaca gcatcccggg                                                   20


<210> 17695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17695
cccaaaaggg acagcatccc                                                   20


<210> 17696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17696
ccccaaaagg gacagcatcc                                                   20


<210> 17697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17697
gtccattccc ccaaaaggga                                                   20


<210> 17698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17698
gaaagtccat tcccccaaaa                                                   20


<210> 17699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17699
agaaagtcca ttcccccaaa                                                   20


<210> 17700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17700
cagaaagtcc attcccccaa                                                   20


<210> 17701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17701
ttccctcaac tgctctcaga                                                   20


<210> 17702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17702
aactttccct caactgctct                                                   20


<210> 17703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17703
ccactgaggc gggtcactcc                                                   20


<210> 17704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17704
tccactgagg cgggtcactc                                                   20


<210> 17705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17705
caagcctcgt ccactgaggc                                                   20


<210> 17706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17706
ccaagcctcg tccactgagg                                                   20


<210> 17707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17707
cttccaagcc tcgtccactg                                                   20


<210> 17708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17708
gcttccaagc ctcgtccact                                                   20


<210> 17709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17709
atggtggaaa atatgcttcc                                                   20


<210> 17710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17710
ggggggctcc tcctttatgg                                                   20


<210> 17711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17711
agcggggggc tcctccttta                                                   20


<210> 17712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17712
atgtccctct gctcagcggg                                                   20


<210> 17713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17713
aatgtccctc tgctcagcgg                                                   20


<210> 17714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17714
aaatgtccct ctgctcagcg                                                   20


<210> 17715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17715
taaatgtccc tctgctcagc                                                   20


<210> 17716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17716
ctaaatgtcc ctctgctcag                                                   20


<210> 17717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17717
tccctaaatg tccctctgct                                                   20


<210> 17718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17718
agggtggttg caggaagggc                                                   20


<210> 17719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17719
catgagggtg gttgcaggaa                                                   20


<210> 17720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17720
acatgagggt ggttgcagga                                                   20


<210> 17721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17721
cacatgaggg tggttgcagg                                                   20


<210> 17722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17722
tggcacatga gggtggttgc                                                   20


<210> 17723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17723
ttggcacatg agggtggttg                                                   20


<210> 17724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17724
agggctttgg cacatgaggg                                                   20


<210> 17725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17725
cccagggctt tggcacatga                                                   20


<210> 17726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17726
gcccagggct ttggcacatg                                                   20


<210> 17727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17727
agcccagggc tttggcacat                                                   20


<210> 17728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17728
aggaacagag cccagggctt                                                   20


<210> 17729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17729
agagtcagga acagagccca                                                   20


<210> 17730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17730
cagagtcagg aacagagccc                                                   20


<210> 17731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17731
ccagagtcag gaacagagcc                                                   20


<210> 17732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17732
ggattccaga gtcaggaaca                                                   20


<210> 17733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17733
caggattcca gagtcaggaa                                                   20


<210> 17734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17734
gtgcccagga ttccagagtc                                                   20


<210> 17735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17735
tgtgcccagg attccagagt                                                   20


<210> 17736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17736
aagatgtgcc caggattcca                                                   20


<210> 17737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17737
gcaagatgtg cccaggattc                                                   20


<210> 17738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17738
ggaagcagca agatgtgccc                                                   20


<210> 17739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17739
tggaagcagc aagatgtgcc                                                   20


<210> 17740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17740
agtgaagaac tggaagcagc                                                   20


<210> 17741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17741
ctcaagtgaa gaactggaag                                                   20


<210> 17742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17742
gctctcaagt gaagaactgg                                                   20


<210> 17743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17743
tctgctctca agtgaagaac                                                   20


<210> 17744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17744
tcttcatctg ctctcaagtg                                                   20


<210> 17745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17745
accgctcttc atctgctctc                                                   20


<210> 17746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17746
gacaggaagt ttacccctct                                                   20


<210> 17747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17747
gcccctcacc ctcagacagg                                                   20


<210> 17748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17748
gatgcccctc accctcagac                                                   20


<210> 17749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17749
agatgcccct caccctcaga                                                   20


<210> 17750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17750
ccacagatgc ccctcaccct                                                   20


<210> 17751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17751
ccaccatccc tgcagagcca                                                   20


<210> 17752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17752
ctgagcccac catccctgca                                                   20


<210> 17753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17753
ggctgagccc accatccctg                                                   20


<210> 17754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17754
aaactctgtt cttccaggct                                                   20


<210> 17755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17755
cccagaaact ctgttcttcc                                                   20


<210> 17756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17756
tcccagaaac tctgttcttc                                                   20


<210> 17757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17757
ggatgcctct gcctgcatcc                                                   20


<210> 17758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17758
ccaccctggt gcctgagcca                                                   20


<210> 17759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17759
tccaccctgg tgcctgagcc                                                   20


<210> 17760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17760
ttccaccctg gtgcctgagc                                                   20


<210> 17761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17761
tcttttccac cctggtgcct                                                   20


<210> 17762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17762
ctctttagtc ttttccaccc                                                   20


<210> 17763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17763
aacaacaaat ccagactctt                                                   20


<210> 17764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17764
aagggaagca acaacaaatc                                                   20


<210> 17765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17765
aagctaaacc aagaaaaggg                                                   20


<210> 17766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17766
agaaagctaa accaagaaaa                                                   20


<210> 17767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17767
aagaaagcta aaccaagaaa                                                   20


<210> 17768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17768
gaagaaagct aaaccaagaa                                                   20


<210> 17769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17769
agacagaaga aagctaaacc                                                   20


<210> 17770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17770
tgagttttat agacagaaga                                                   20


<210> 17771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17771
ctcatgagtt ttatagacag                                                   20


<210> 17772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17772
ttcctcatga gttttataga                                                   20


<210> 17773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17773
ttctttcctc atgagtttta                                                   20


<210> 17774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17774
aacttgggtt ctttcctcat                                                   20


<210> 17775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17775
ccctggacat caaccaactt                                                   20


<210> 17776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17776
gccctggaca tcaaccaact                                                   20


<210> 17777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17777
aagccccttt cttattgccc                                                   20


<210> 17778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17778
gggaggatgc agtcttccag                                                   20


<210> 17779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17779
tgtgggagga tgcagtcttc                                                   20


<210> 17780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17780
actggttgtg tgggaggatg                                                   20


<210> 17781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17781
ggactgactg gttgtgtggg                                                   20


<210> 17782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17782
gggactgact ggttgtgtgg                                                   20


<210> 17783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17783
ctgggactga ctggttgtgt                                                   20


<210> 17784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17784
cctgggactg actggttgtg                                                   20


<210> 17785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17785
cttgccctcc tgggactgac                                                   20


<210> 17786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17786
ggtggggtcc ttgccctcct                                                   20


<210> 17787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17787
tggtggggtc cttgccctcc                                                   20


<210> 17788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17788
cacccactct ggtcatggtg                                                   20


<210> 17789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17789
ccacccactc tggtcatggt                                                   20


<210> 17790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17790
tccacccact ctggtcatgg                                                   20


<210> 17791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17791
gtctccaccc actctggtca                                                   20


<210> 17792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17792
cagcttgtct ccacccactc                                                   20


<210> 17793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17793
ccagcctggc cccctgccct                                                   20


<210> 17794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17794
accccttctc cgccccagcc                                                   20


<210> 17795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17795
ccaatacccc ttctccgccc                                                   20


<210> 17796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17796
ctggagactc acttgccaat                                                   20


<210> 17797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17797
gtttggagga agcccctctg                                                   20


<210> 17798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17798
atgtttggag gaagcccctc                                                   20


<210> 17799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17799
atctactcca tgtttggagg                                                   20


<210> 17800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17800
aaaatctact ccatgtttgg                                                   20


<210> 17801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17801
caaaatctac tccatgtttg                                                   20


<210> 17802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17802
aacaaaatct actccatgtt                                                   20


<210> 17803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17803
acggacaaca tccaaggcca                                                   20


<210> 17804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17804
tgggtcacgg acaacatcca                                                   20


<210> 17805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17805
atgggtcacg gacaacatcc                                                   20


<210> 17806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17806
ggagggggca caatgggtca                                                   20


<210> 17807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17807
ctgcagggag ggggcacaat                                                   20


<210> 17808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17808
gctgcaggga gggggcacaa                                                   20


<210> 17809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17809
ggggagaggc tgcagggagg                                                   20


<210> 17810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17810
gggggagagg ctgcagggag                                                   20


<210> 17811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17811
agggggagag gctgcaggga                                                   20


<210> 17812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17812
cagggggaga ggctgcaggg                                                   20


<210> 17813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17813
gcagggggag aggctgcagg                                                   20


<210> 17814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17814
gagcaggggg agaggctgca                                                   20


<210> 17815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17815
ggagcagggg gagaggctgc                                                   20


<210> 17816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17816
gggagcaggg ggagaggctg                                                   20


<210> 17817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17817
ctagctggga gcagggggag                                                   20


<210> 17818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17818
cctagctggg agcaggggga                                                   20


<210> 17819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17819
gtcctagctg ggagcagggg                                                   20


<210> 17820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17820
aggtcctagc tgggagcagg                                                   20


<210> 17821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17821
caggtcctag ctgggagcag                                                   20


<210> 17822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17822
acaggtccta gctgggagca                                                   20


<210> 17823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17823
cacaggtcct agctgggagc                                                   20


<210> 17824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17824
gcacaggtcc tagctgggag                                                   20


<210> 17825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17825
gctgcacagg tcctagctgg                                                   20


<210> 17826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17826
aagctgcaca ggtcctagct                                                   20


<210> 17827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17827
caagctgcac aggtcctagc                                                   20


<210> 17828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17828
tctccaagct gcacaggtcc                                                   20


<210> 17829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17829
ctgatttctc caagctgcac                                                   20


<210> 17830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17830
actgatttct ccaagctgca                                                   20


<210> 17831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17831
aagagctgac tgatttctcc                                                   20


<210> 17832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17832
atttttattc agggaagtaa                                                   20


<210> 17833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17833
acatttttat tcagggaagt                                                   20


<210> 17834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17834
gaaaacattt ttattcaggg                                                   20


<210> 17835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17835
tcagaaaaca tttttattca                                                   20


<210> 17836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17836
ctcagaaaac atttttattc                                                   20


<210> 17837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17837
gctcagaaaa catttttatt                                                   20


<210> 17838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17838
ttccccaatc tgagggggct                                                   20


<210> 17839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17839
tgtccttccc caatctgagg                                                   20


<210> 17840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17840
atgtccttcc ccaatctgag                                                   20


<210> 17841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17841
aatgtccttc cccaatctga                                                   20


<210> 17842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17842
aaatgtcctt ccccaatctg                                                   20


<210> 17843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17843
aaaatgtcct tccccaatct                                                   20


<210> 17844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17844
cggtgtctat tagctgttaa                                                   20


<210> 17845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17845
acggtgtcta ttagctgtta                                                   20


<210> 17846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17846
actcaataaa cggtgtctat                                                   20


<210> 17847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17847
tgaggcagga actcaataaa                                                   20


<210> 17848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17848
tgcaatgtct gggctgaggc                                                   20


<210> 17849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17849
atgcaatgtc tgggctgagg                                                   20


<210> 17850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17850
ctaatgcaat gtctgggctg                                                   20


<210> 17851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17851
cctaatgcaa tgtctgggct                                                   20


<210> 17852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17852
aattgcctaa tgcaatgtct                                                   20


<210> 17853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17853
aaattgccta atgcaatgtc                                                   20


<210> 17854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17854
ctgggagaat taaatgacag                                                   20


<210> 17855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17855
tactgggaga attaaatgac                                                   20


<210> 17856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17856
ttactgggag aattaaatga                                                   20


<210> 17857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17857
cttactcatg ggtttactgg                                                   20


<210> 17858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17858
tgcttactca tgggtttact                                                   20


<210> 17859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17859
atgcttactc atgggtttac                                                   20


<210> 17860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17860
agaaaataat gcttactcat                                                   20


<210> 17861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17861
aagaaaataa tgcttactca                                                   20


<210> 17862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17862
gatctaattt ccttaaaatc                                                   20


<210> 17863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17863
gcaagagact taatctcctc                                                   20


<210> 17864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17864
aggtgggtga ccccaggcaa                                                   20


<210> 17865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17865
ctaggtgggt gaccccaggc                                                   20


<210> 17866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17866
tttactaggt gggtgacccc                                                   20


<210> 17867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17867
atttactagg tgggtgaccc                                                   20


<210> 17868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17868
tgctccacca tttactaggt                                                   20


<210> 17869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17869
ctgctccacc atttactagg                                                   20


<210> 17870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17870
tctctgctcc accatttact                                                   20


<210> 17871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17871
atctctgctc caccatttac                                                   20


<210> 17872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17872
tagaaaagaa agacctggtg                                                   20


<210> 17873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17873
atgattagaa aagaaagacc                                                   20


<210> 17874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17874
gaacatatga ttagaaaaga                                                   20


<210> 17875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17875
atgagaacat atgattagaa                                                   20


<210> 17876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17876
caggaatgag aacatatgat                                                   20


<210> 17877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17877
gcagtctgac ttgcaggaat                                                   20


<210> 17878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17878
tgggaggcag tctgacttgc                                                   20


<210> 17879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17879
ttgggaggca gtctgacttg                                                   20


<210> 17880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17880
aagaagtgtg ccttgggagg                                                   20


<210> 17881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17881
tacaagaagt gtgccttggg                                                   20


<210> 17882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17882
ttacaagaag tgtgccttgg                                                   20


<210> 17883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17883
cattacaaga agtgtgcctt                                                   20


<210> 17884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17884
tcattacaag aagtgtgcct                                                   20


<210> 17885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17885
catgtgggat tcattacaag                                                   20


<210> 17886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17886
attcatgtgg gattcattac                                                   20


<210> 17887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17887
caaacttttc aaattcatgt                                                   20


<210> 17888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17888
tcaaactttt caaattcatg                                                   20


<210> 17889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17889
attgtacttc tctggttgaa                                                   20


<210> 17890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17890
atgcccagat tgtacttctc                                                   20


<210> 17891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17891
ttgatctgca tttttatgcc                                                   20


<210> 17892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17892
ggcttctggg ttatctgaaa                                                   20


<210> 17893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17893
ggggaaagga gaaggcttct                                                   20


<210> 17894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17894
tggggaaagg agaaggcttc                                                   20


<210> 17895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17895
tgtctcctgg ggaaaggaga                                                   20


<210> 17896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17896
ctgtctcctg gggaaaggag                                                   20


<210> 17897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17897
gcactgtctc ctggggaaag                                                   20


<210> 17898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17898
gggcactgtc tcctggggaa                                                   20


<210> 17899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17899
ggggcactgt ctcctgggga                                                   20


<210> 17900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17900
gctgggggca ctgtctcctg                                                   20


<210> 17901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17901
tgctgggggc actgtctcct                                                   20


<210> 17902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17902
ctgctggggg cactgtctcc                                                   20


<210> 17903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17903
tgagtggtga accctgctgg                                                   20


<210> 17904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17904
gtgagtggtg aaccctgctg                                                   20


<210> 17905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17905
ggtgagtggt gaaccctgct                                                   20


<210> 17906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17906
tggtgagtgg tgaaccctgc                                                   20


<210> 17907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17907
ctagggaacc tggtggtgag                                                   20


<210> 17908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17908
gtgctaggga acctggtggt                                                   20


<210> 17909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17909
gatggtgcta gggaacctgg                                                   20


<210> 17910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17910
ggtgatggtg ctagggaacc                                                   20


<210> 17911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17911
tcttgacggt gatggtgcta                                                   20


<210> 17912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17912
ttcttgacgg tgatggtgct                                                   20


<210> 17913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17913
tttcttgacg gtgatggtgc                                                   20


<210> 17914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17914
catccttttc ttgacggtga                                                   20


<210> 17915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17915
atgcctcatc cttttcttga                                                   20


<210> 17916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17916
atgtgggcct gcatggaagt                                                   20


<210> 17917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17917
gaacatgtgg gcctgcatgg                                                   20


<210> 17918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17918
tgagaacatg tgggcctgca                                                   20


<210> 17919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17919
agagtggatt gagaacatgt                                                   20


<210> 17920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17920
gagagtggat tgagaacatg                                                   20


<210> 17921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17921
tcctctgtgg agagtggatt                                                   20


<210> 17922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17922
tccgtatcct ctgtggagag                                                   20


<210> 17923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17923
tcttccgtat cctctgtgga                                                   20


<210> 17924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17924
tgtcttccgt atcctctgtg                                                   20


<210> 17925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17925
attgtcttcc gtatcctctg                                                   20


<210> 17926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17926
cccatgaaga ctggccccgc                                                   20


<210> 17927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17927
tctccgcgcc ccatgaagac                                                   20


<210> 17928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17928
aaatatctcc gcgccccatg                                                   20


<210> 17929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17929
ggttggcaag cagctcctag                                                   20


<210> 17930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17930
tggttggcaa gcagctccta                                                   20


<210> 17931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17931
ctggttggca agcagctcct                                                   20


<210> 17932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17932
tctggttggc aagcagctcc                                                   20


<210> 17933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17933
tctttgctct ggttggcaag                                                   20


<210> 17934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17934
ttgtctttgc tctggttggc                                                   20


<210> 17935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17935
gtctttgtct ttgctctggt                                                   20


<210> 17936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17936
cattgtcttt gtctttgctc                                                   20


<210> 17937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17937
ggggaacctc accatcatcc                                                   20


<210> 17938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17938
gaaactcagt gggggcactg                                                   20


<210> 17939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17939
ggaaactcag tgggggcact                                                   20


<210> 17940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17940
cggaaactca gtgggggcac                                                   20


<210> 17941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17941
gatcatcgga aactcagtgg                                                   20


<210> 17942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17942
agatcatcgg aaactcagtg                                                   20


<210> 17943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17943
aagatcatcg gaaactcagt                                                   20


<210> 17944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17944
caagatcatc ggaaactcag                                                   20


<210> 17945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17945
catcaagatc atcggaaact                                                   20


<210> 17946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17946
aacacactca tcaagatcat                                                   20


<210> 17947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17947
ccaccttaaa cacactcatc                                                   20


<210> 17948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17948
tattcaagct ggccaaatcc                                                   20


<210> 17949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17949
gcagctgcgc gtattcaagc                                                   20


<210> 17950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17950
ctctgcagct gcgcgtattc                                                   20


<210> 17951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17951
tgacggtctc tgtttctctg                                                   20


<210> 17952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 17952
gcacagctac caaaacctga                                                   20


<210> 17953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17953
tagatgaaag gtaatgagca                                                   20


<210> 17954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17954
aactttagat gaaaggtaat                                                   20


<210> 17955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17955
caggcaaaac tttagatgaa                                                   20


<210> 17956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17956
ccaggcaaaa ctttagatga                                                   20


<210> 17957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17957
ttggtttcca ggcaaaactt                                                   20


<210> 17958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17958
ttcccagatc tttggtttcc                                                   20


<210> 17959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17959
tttcccagat ctttggtttc                                                   20


<210> 17960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17960
ttgtgttttt cccagatctt                                                   20


<210> 17961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17961
gagaggcctt gtgtttttcc                                                   20


<210> 17962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17962
ccctggttta atgggatgag                                                   20


<210> 17963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17963
gccctggttt aatgggatga                                                   20


<210> 17964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17964
acgccctggt ttaatgggat                                                   20


<210> 17965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17965
agaaaacgcc ctggtttaat                                                   20


<210> 17966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17966
cagaaaacgc cctggtttaa                                                   20


<210> 17967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17967
gcagtgtcca gaaaacgccc                                                   20


<210> 17968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17968
aggtctccaa aagcagtgtc                                                   20


<210> 17969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17969
ggaagaaagg tctccaaaag                                                   20


<210> 17970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17970
ataggaagaa aggtctccaa                                                   20


<210> 17971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17971
aatttatagc ataggaagaa                                                   20


<210> 17972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17972
taatttatag cataggaaga                                                   20


<210> 17973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17973
tgagtaattt atagcatagg                                                   20


<210> 17974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17974
ttttgagtaa tttatagcat                                                   20


<210> 17975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17975
tttttgagta atttatagca                                                   20


<210> 17976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17976
tcatattttt gagtaattta                                                   20


<210> 17977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17977
agaaggcaga tcatattttt                                                   20


<210> 17978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17978
tacttatgaa ccatagaagg                                                   20


<210> 17979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17979
tgatacttat gaaccataga                                                   20


<210> 17980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17980
ttgatactta tgaaccatag                                                   20


<210> 17981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17981
acattgatac ttatgaacca                                                   20


<210> 17982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17982
tgactcagcc acagtcaatg                                                   20


<210> 17983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17983
agaagaccct gactcagcca                                                   20


<210> 17984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17984
cccagtagaa gaccctgact                                                   20


<210> 17985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17985
caaggccacc accccagtag                                                   20


<210> 17986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17986
tcgcaaggcc accaccccag                                                   20


<210> 17987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17987
agatcgcaag gccaccaccc                                                   20


<210> 17988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17988
agaacagagt acagatcgca                                                   20


<210> 17989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 17989
tagaacagag tacagatcgc                                                   20


<210> 17990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17990
tgtggctata gaacagagta                                                   20


<210> 17991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17991
aggcctgtgg ctatagaaca                                                   20


<210> 17992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17992
tcaggcctgt ggctatagaa                                                   20


<210> 17993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 17993
agggatcagg cctgtggcta                                                   20


<210> 17994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 17994
ttcaggaggg atcaggcctg                                                   20


<210> 17995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17995
gcccatattc aggagggatc                                                   20


<210> 17996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 17996
ggcccatatt caggagggat                                                   20


<210> 17997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 17997
gaagaggccc atattcagga                                                   20


<210> 17998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 17998
agaagaggcc catattcagg                                                   20


<210> 17999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 17999
cagaagaggc ccatattcag                                                   20


<210> 18000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18000
cacagaagag gcccatattc                                                   20


<210> 18001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18001
ccacagaaga ggcccatatt                                                   20


<210> 18002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18002
ccaccccacc tccacagaag                                                   20


<210> 18003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18003
cccaccccac ctccacagaa                                                   20


<210> 18004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18004
cacccacccc acctccacag                                                   20


<210> 18005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18005
tcacacccac cccacctcca                                                   20


<210> 18006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18006
gcttgttctc acttatttgt                                                   20


<210> 18007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18007
gtctctcttc agtcataaat                                                   20


<210> 18008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18008
gaaggaggct ggtctctctt                                                   20


<210> 18009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18009
atcccctacc cgaaggaggc                                                   20


<210> 18010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18010
ggtcatcccc tacccgaagg                                                   20


<210> 18011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18011
gggtcatccc ctacccgaag                                                   20


<210> 18012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18012
gtgggtcatc ccctacccga                                                   20


<210> 18013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18013
agtgggtcat cccctacccg                                                   20


<210> 18014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18014
caatacctat cgaatgcagt                                                   20


<210> 18015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18015
ccaataccta tcgaatgcag                                                   20


<210> 18016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18016
ttgccaatac ctatcgaatg                                                   20


<210> 18017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18017
caagatgaga aatgccctaa                                                   20


<210> 18018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18018
cccaagatga gaaatgccct                                                   20


<210> 18019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18019
gttgtccact gccccaagat                                                   20


<210> 18020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18020
cagatgttgt ccactgcccc                                                   20


<210> 18021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18021
ttcaaagctg gtgggagcaa                                                   20


<210> 18022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18022
tgcagtttca aagctggtgg                                                   20


<210> 18023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18023
tttgcagttt caaagctggt                                                   20


<210> 18024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18024
atttgcagtt tcaaagctgg                                                   20


<210> 18025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18025
gacatttgca gtttcaaagc                                                   20


<210> 18026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18026
catggacatt tgcagtttca                                                   20


<210> 18027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18027
catgaaatca tggacatttg                                                   20


<210> 18028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18028
atgctgagtc catgaaatca                                                   20


<210> 18029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18029
taaatcaact tatgaatgct                                                   20


<210> 18030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18030
gttctggggg gtaggttcgt                                                   20


<210> 18031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18031
cggctggagt tctggggggt                                                   20


<210> 18032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18032
acggctggag ttctgggggg                                                   20


<210> 18033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18033
tgcacggctg gagttctggg                                                   20


<210> 18034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18034
ctgcacggct ggagttctgg                                                   20


<210> 18035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18035
cctgcacggc tggagttctg                                                   20


<210> 18036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18036
acctgcacgg ctggagttct                                                   20


<210> 18037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18037
cacctgcacg gctggagttc                                                   20


<210> 18038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18038
gccatgcacc tgcacggctg                                                   20


<210> 18039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18039
ctgccatgca cctgcacggc                                                   20


<210> 18040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18040
cacactgcca tgcacctgca                                                   20


<210> 18041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18041
tcttcataca cctcataggc                                                   20


<210> 18042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18042
cctctcttca tacacctcat                                                   20


<210> 18043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18043
acctctcttc atacacctca                                                   20


<210> 18044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18044
cattggttcc atgagagcaa                                                   20


<210> 18045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18045
accattggtt ccatgagagc                                                   20


<210> 18046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18046
ctaaaccatt ggttccatga                                                   20


<210> 18047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18047
aactaaacca ttggttccat                                                   20


<210> 18048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18048
tttctcagta actaaaccat                                                   20


<210> 18049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18049
tttgagactt catcttttct                                                   20


<210> 18050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18050
agtttacagt gaagactttt                                                   20


<210> 18051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18051
gcatatttga gtttacagtg                                                   20


<210> 18052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18052
acttagcata tttgagttta                                                   20


<210> 18053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18053
ttgtgggact tagcatattt                                                   20


<210> 18054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18054
ttttgctgtc ttgtgggact                                                   20


<210> 18055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18055
tgatgatttt gctgtcttgt                                                   20


<210> 18056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18056
ttgatgattt tgctgtcttg                                                   20


<210> 18057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18057
ttttttttcc tgacaaatta                                                   20


<210> 18058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18058
gatttttttt cctgacaaat                                                   20


<210> 18059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18059
gacagactga cagttgagct                                                   20


<210> 18060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18060
tgactgacag actgacagtt                                                   20


<210> 18061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18061
caccttgact gacagactga                                                   20


<210> 18062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18062
cataaacaca ccttgactga                                                   20


<210> 18063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18063
gccacagcct ggctcttagt                                                   20


<210> 18064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18064
agccacagcc tggctcttag                                                   20


<210> 18065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18065
ctaagccaca gcctggctct                                                   20


<210> 18066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18066
ctagcaccta agccacagcc                                                   20


<210> 18067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18067
gcatcctagc acctaagcca                                                   20


<210> 18068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18068
agcattgcat cctagcacct                                                   20


<210> 18069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18069
ttgtgttcag cattgcatcc                                                   20


<210> 18070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18070
tgtagctaca ctgttgtgtt                                                   20


<210> 18071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18071
ggatatgggt gataaaattg                                                   20


<210> 18072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18072
tgggatttac tcacggatat                                                   20


<210> 18073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18073
gtgggattta ctcacggata                                                   20


<210> 18074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18074
cctcccgtgg gatttactca                                                   20


<210> 18075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18075
aggattaaac ctcctcccgt                                                   20


<210> 18076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18076
caggattaaa cctcctcccg                                                   20


<210> 18077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18077
tacagcactt actgtataac                                                   20


<210> 18078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18078
atacagcact tactgtataa                                                   20


<210> 18079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18079
atcacataaa gaggtgcata                                                   20


<210> 18080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18080
ctctccccca tcacataaag                                                   20


<210> 18081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18081
gctctccccc atcacataaa                                                   20


<210> 18082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18082
ccgctctccc ccatcacata                                                   20


<210> 18083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18083
gattgggtgt aaggtgaacg                                                   20


<210> 18084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18084
taacttccag attgggtgta                                                   20


<210> 18085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18085
gtaacttcca gattgggtgt                                                   20


<210> 18086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18086
aggagagtaa cttccagatt                                                   20


<210> 18087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18087
gaggagagta acttccagat                                                   20


<210> 18088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18088
catatgagga gagtaacttc                                                   20


<210> 18089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18089
ctctgcttcc catatgagga                                                   20


<210> 18090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18090
agctctgctt cccatatgag                                                   20


<210> 18091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18091
taagctctgc ttcccatatg                                                   20


<210> 18092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18092
ttaagctctg cttcccatat                                                   20


<210> 18093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18093
gtccacagag ttgttgtttt                                                   20


<210> 18094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18094
gcctctgtga ccagtccaca                                                   20


<210> 18095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18095
ctgcctctgt gaccagtcca                                                   20


<210> 18096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18096
ttatcagctg cctctgtgac                                                   20


<210> 18097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18097
cagtttttat ttgtgtttat                                                   20


<210> 18098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18098
ccatactagt tactaatgct                                                   20


<210> 18099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18099
acgtttcctg ctccccatac                                                   20


<210> 18100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18100
ttacaacctt cggcaggcca                                                   20


<210> 18101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18101
ctaggcttac aaccttcggc                                                   20


<210> 18102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18102
gctaggctta caaccttcgg                                                   20


<210> 18103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18103
cctgctaggc ttacaacctt                                                   20


<210> 18104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18104
agcagggaga aattcctgct                                                   20


<210> 18105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18105
aagcagggag aaattcctgc                                                   20


<210> 18106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18106
ggatctagtc ttaaagcagg                                                   20


<210> 18107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18107
tgggatctag tcttaaagca                                                   20


<210> 18108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18108
ttgggatcta gtcttaaagc                                                   20


<210> 18109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18109
tttgggatct agtcttaaag                                                   20


<210> 18110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18110
ctctttggga tctagtctta                                                   20


<210> 18111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18111
gggtatagct ctttgggatc                                                   20


<210> 18112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18112
catgaagggt atagctcttt                                                   20


<210> 18113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18113
acatgaaggg tatagctctt                                                   20


<210> 18114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18114
tcatccttac atgaagggta                                                   20


<210> 18115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18115
gtggttcatc cttacatgaa                                                   20


<210> 18116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18116
tgtggttcat ccttacatga                                                   20


<210> 18117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18117
ttgtggttca tccttacatg                                                   20


<210> 18118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18118
cattctcctg ggattgtttg                                                   20


<210> 18119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18119
aattttcctt gcattctcct                                                   20


<210> 18120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18120
caattttcct tgcattctcc                                                   20


<210> 18121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18121
ctgtagctgg tacctaacac                                                   20


<210> 18122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18122
gtcaattttc ctcctgtagc                                                   20


<210> 18123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18123
cagcgtcaat tttcctcctg                                                   20


<210> 18124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18124
actttgttgt ttcaaatgct                                                   20


<210> 18125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18125
ttccagataa aatcctatat                                                   20


<210> 18126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18126
tacctaggta gtgtgaattc                                                   20


<210> 18127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18127
ctcaacttaa aatacctagg                                                   20


<210> 18128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18128
attctcaact taaaatacct                                                   20


<210> 18129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18129
aattctcaac ttaaaatacc                                                   20


<210> 18130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18130
taattctgca gagcactttg                                                   20


<210> 18131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18131
tatttgcatt taattctgca                                                   20


<210> 18132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18132
ggtatttgca tttaattctg                                                   20


<210> 18133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18133
ataaaggcag gttcctccag                                                   20


<210> 18134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18134
gataaaggca ggttcctcca                                                   20


<210> 18135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18135
gagataaagg caggttcctc                                                   20


<210> 18136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18136
ttgaaacctg agataaaggc                                                   20


<210> 18137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18137
tttgaaacct gagataaagg                                                   20


<210> 18138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18138
tagtttgaaa cctgagataa                                                   20


<210> 18139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18139
atagtttgaa acctgagata                                                   20


<210> 18140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18140
gagggaatag tttgaaacct                                                   20


<210> 18141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18141
ttaaacaatt tttgagggaa                                                   20


<210> 18142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18142
aactcttaaa caatttttga                                                   20


<210> 18143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18143
caactcttaa acaatttttg                                                   20


<210> 18144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18144
gcaactctta aacaattttt                                                   20


<210> 18145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18145
tccacatctg tggtttcttc                                                   20


<210> 18146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18146
aatgactatt tccacatctg                                                   20


<210> 18147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18147
aattctatca tctgaagaaa                                                   20


<210> 18148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18148
actaataatt ctatcatctg                                                   20


<210> 18149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18149
tattctctgc acatagtttc                                                   20


<210> 18150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18150
gtttttttat tctctgcaca                                                   20


<210> 18151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18151
caacttgtta ttgttatcta                                                   20


<210> 18152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18152
attatatttt tcatttctaa                                                   20


<210> 18153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18153
gtattatatt tttcatttct                                                   20


<210> 18154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18154
ttcataatat ttttaatttt                                                   20


<210> 18155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18155
aatttattct gatatatcct                                                   20


<210> 18156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18156
ttttcatctt atgtctctct                                                   20


<210> 18157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18157
tttttcatct tatgtctctc                                                   20


<210> 18158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18158
ccttctggac tttggttaga                                                   20


<210> 18159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18159
ttctccttct ggactttggt                                                   20


<210> 18160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18160
ttttttctcc ttctggactt                                                   20


<210> 18161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18161
cattctattt tttctccttc                                                   20


<210> 18162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18162
agacatgatg tgggcagtca                                                   20


<210> 18163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18163
gttcccagac atgatgtggg                                                   20


<210> 18164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18164
aaagttccca gacatgatgt                                                   20


<210> 18165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18165
gaaagttccc agacatgatg                                                   20


<210> 18166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18166
cttcaattct ggaaagttcc                                                   20


<210> 18167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18167
taattttctt caattctgga                                                   20


<210> 18168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18168
tttgtaattt tcttcaattc                                                   20


<210> 18169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18169
atactgactt cttgaatctt                                                   20


<210> 18170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18170
tctttccatt tataatgctt                                                   20


<210> 18171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18171
cactgtaata tgtctaggtg                                                   20


<210> 18172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18172
agtttcactg taatatgtct                                                   20


<210> 18173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18173
cagtttcact gtaatatgtc                                                   20


<210> 18174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18174
tatccatctt tggtgttctg                                                   20


<210> 18175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18175
ttaaatcttc tatccatctt                                                   20


<210> 18176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18176
aactgttatt ccttcctttc                                                   20


<210> 18177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18177
cattgttgct aatgagcagt                                                   20


<210> 18178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18178
cctccattgt tgctaatgag                                                   20


<210> 18179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18179
tagcctccat tgttgctaat                                                   20


<210> 18180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18180
gaagatagta ttccaacaat                                                   20


<210> 18181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18181
ttatcttcct tcagtgaaga                                                   20


<210> 18182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18182
tactttatct tccttcagtg                                                   20


<210> 18183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18183
gttgatactt tatcttcctt                                                   20


<210> 18184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18184
ttcttatgaa tgtaaaattc                                                   20


<210> 18185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18185
cagtttgccc gtgtctttga                                                   20


<210> 18186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18186
ttcagtttgc ccgtgtcttt                                                   20


<210> 18187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18187
tttatctgaa atttgctctt                                                   20


<210> 18188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18188
ttcttttagt aagtgccttc                                                   20


<210> 18189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18189
cctttagaat ttcttttagt                                                   20


<210> 18190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18190
acctccttta gaatttcttt                                                   20


<210> 18191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18191
tctacctgaa gtacctcctt                                                   20


<210> 18192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18192
gatcactttc tatctacctg                                                   20


<210> 18193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18193
acacattaca tattacttct                                                   20


<210> 18194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18194
tacacattac atattacttc                                                   20


<210> 18195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18195
ttcttcaacc ctttggagca                                                   20


<210> 18196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18196
ttgatttctt caaccctttg                                                   20


<210> 18197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18197
tattgatttc ttcaaccctt                                                   20


<210> 18198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18198
atcctgtaag cctaaaaatt                                                   20


<210> 18199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18199
tttcttatct ggtatcctgt                                                   20


<210> 18200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18200
tcagtgagtt atttcttatc                                                   20


<210> 18201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18201
ttgagtttca gattttcagt                                                   20


<210> 18202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18202
cagtttgagt ttcagatttt                                                   20


<210> 18203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18203
ttggaacaca gtttgagttt                                                   20


<210> 18204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18204
tactctttgg aacacagttt                                                   20


<210> 18205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18205
atttcttact ctttggaaca                                                   20


<210> 18206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18206
gttactgatt tcttactctt                                                   20


<210> 18207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18207
aaaaactcaa gaatttttgt                                                   20


<210> 18208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18208
atctgctatc ctaaaaactc                                                   20


<210> 18209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18209
gggagtttca gtgtctcagc                                                   20


<210> 18210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18210
gggagggagt ttcagtgtct                                                   20


<210> 18211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18211
cacacaaggg gagggagttt                                                   20


<210> 18212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18212
catcatcaca caaggggagg                                                   20


<210> 18213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18213
ttcatcatca cacaagggga                                                   20


<210> 18214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18214
tttcatcatc acacaagggg                                                   20


<210> 18215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18215
ttttcatcat cacacaaggg                                                   20


<210> 18216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18216
ttttttcatc atcacacaag                                                   20


<210> 18217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18217
gttttttcat catcacacaa                                                   20


<210> 18218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18218
tgttttttca tcatcacaca                                                   20


<210> 18219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18219
ctgttttttc atcatcacac                                                   20


<210> 18220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18220
atcctggttc caattgattt                                                   20


<210> 18221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18221
caaactccag tcggccatcc                                                   20


<210> 18222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18222
cattctgcac aaactccagt                                                   20


<210> 18223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18223
agctcattct gcacaaactc                                                   20


<210> 18224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18224
attcagtcca tgacgtcagc                                                   20


<210> 18225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18225
ggaaattcag tccatgacgt                                                   20


<210> 18226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18226
tgcaatatga agtggaaatt                                                   20


<210> 18227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18227
agttagtatg caatatgaag                                                   20


<210> 18228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18228
gggagttagt atgcaatatg                                                   20


<210> 18229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18229
tatgcaaatc tggggggagt                                                   20


<210> 18230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18230
tgcatatgca aatctggggg                                                   20


<210> 18231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18231
gttgcatatg caaatctggg                                                   20


<210> 18232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18232
ggttgcatat gcaaatctgg                                                   20


<210> 18233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18233
gggttgcata tgcaaatctg                                                   20


<210> 18234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18234
tgggttgcat atgcaaatct                                                   20


<210> 18235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18235
atgggttgca tatgcaaatc                                                   20


<210> 18236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18236
atctcttcat gcttactcat                                                   20


<210> 18237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18237
tatctcttca tgcttactca                                                   20


<210> 18238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18238
ggagagtcca tgggcctgca                                                   20


<210> 18239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18239
gggaggtttg gagagtccat                                                   20


<210> 18240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18240
ggggaggttt ggagagtcca                                                   20


<210> 18241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18241
aaggaaaggg gaggtttgga                                                   20


<210> 18242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18242
ggaaggaaag gggaggtttg                                                   20


<210> 18243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18243
gtggaaggaa aggggaggtt                                                   20


<210> 18244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18244
gattggtgga aggaaagggg                                                   20


<210> 18245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18245
tgattggtgg aaggaaaggg                                                   20


<210> 18246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18246
ggtgattggt ggaaggaaag                                                   20


<210> 18247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18247
aggtgattgg tggaaggaaa                                                   20


<210> 18248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18248
caggtgattg gtggaaggaa                                                   20


<210> 18249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18249
gcaggtgatt ggtggaagga                                                   20


<210> 18250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18250
atttgcaggt gattggtgga                                                   20


<210> 18251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18251
gatttgcagg tgattggtgg                                                   20


<210> 18252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18252
cgggatttgc aggtgattgg                                                   20


<210> 18253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18253
taccgggatt tgcaggtgat                                                   20


<210> 18254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18254
gggtggatac cgggatttgc                                                   20


<210> 18255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18255
tgggtggata ccgggatttg                                                   20


<210> 18256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18256
atgtttagtg ggtggatacc                                                   20


<210> 18257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18257
aatgtttagt gggtggatac                                                   20


<210> 18258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18258
attagaaaat gtttagtggg                                                   20


<210> 18259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18259
tttattagaa aatgtttagt                                                   20


<210> 18260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18260
ttttattaga aaatgtttag                                                   20


<210> 18261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18261
tatttttatt agaaaatgtt                                                   20


<210> 18262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18262
cttcaaggca gtatttttat                                                   20


<210> 18263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18263
tccctgtgct gtcttcaagg                                                   20


<210> 18264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18264
gtctccctgt gctgtcttca                                                   20


<210> 18265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18265
tgtctccctg tgctgtcttc                                                   20


<210> 18266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18266
agaagacagg aggtcaagct                                                   20


<210> 18267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18267
tggcaagaag acaggaggtc                                                   20


<210> 18268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18268
ctggctggca agaagacagg                                                   20


<210> 18269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18269
gctggctggc aagaagacag                                                   20


<210> 18270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18270
aagctggctg gcaagaagac                                                   20


<210> 18271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18271
caagctggct ggcaagaaga                                                   20


<210> 18272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18272
actgcaagct ggctggcaag                                                   20


<210> 18273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18273
aatactgcaa gctggctggc                                                   20


<210> 18274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18274
gcttaatact gcaagctggc                                                   20


<210> 18275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18275
aaaagcttaa tactgcaagc                                                   20


<210> 18276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18276
aaagaaaagc ttaatactgc                                                   20


<210> 18277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18277
ccaggctttt gagaaaagaa                                                   20


<210> 18278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18278
ggacaccagg cttttgagaa                                                   20


<210> 18279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18279
gacgaggaca ccaggctttt                                                   20


<210> 18280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18280
gaagccaaga cgaggacacc                                                   20


<210> 18281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18281
ggaagccaag acgaggacac                                                   20


<210> 18282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18282
tgactttgga agccaagacg                                                   20


<210> 18283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18283
atgactttgg aagccaagac                                                   20


<210> 18284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18284
atactatgac tttggaagcc                                                   20


<210> 18285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18285
agccaatact atgactttgg                                                   20


<210> 18286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18286
agaagccaat actatgactt                                                   20


<210> 18287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18287
ctcactgccc aatgctctag                                                   20


<210> 18288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18288
gggctcactg cccaatgctc                                                   20


<210> 18289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18289
ctttgttata gagccagtgg                                                   20


<210> 18290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18290
cctttgttat agagccagtg                                                   20


<210> 18291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18291
acctttgtta tagagccagt                                                   20


<210> 18292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18292
tacctttgtt atagagccag                                                   20


<210> 18293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18293
ttataccttt gttatagagc                                                   20


<210> 18294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18294
ctctttatac ctttgttata                                                   20


<210> 18295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18295
tgctctttat acctttgtta                                                   20


<210> 18296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18296
tttagattca ctctcatgct                                                   20


<210> 18297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18297
gtgtccactc aatgtttatt                                                   20


<210> 18298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18298
cagtctcttc cacatctcac                                                   20


<210> 18299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18299
gtgaatggag actatatgac                                                   20


<210> 18300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18300
tgggaggaga aaagtgaatg                                                   20


<210> 18301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18301
tctgggagga gaaaagtgaa                                                   20


<210> 18302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18302
cgttgtgtct gggaggagaa                                                   20


<210> 18303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18303
tcttccgttg tgtctgggag                                                   20


<210> 18304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18304
agtcttccgt tgtgtctggg                                                   20


<210> 18305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18305
cagtcttccg ttgtgtctgg                                                   20


<210> 18306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18306
aacagtcttc cgttgtgtct                                                   20


<210> 18307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18307
aaacagtctt ccgttgtgtc                                                   20


<210> 18308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18308
ttgcaagcaa aactggaaaa                                                   20


<210> 18309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18309
caactatttg caagcaaaac                                                   20


<210> 18310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18310
acatgacccc aactatttgc                                                   20


<210> 18311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18311
tccatctcca ttccaccaga                                                   20


<210> 18312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18312
tgtctccatc tccattccac                                                   20


<210> 18313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18313
gggtttaagg ctatgcctaa                                                   20


<210> 18314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18314
gaaaaagttc agggggttta                                                   20


<210> 18315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18315
agaaaaagtt cagggggttt                                                   20


<210> 18316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18316
agggaaagaa aaagttcagg                                                   20


<210> 18317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18317
aagggaaaga aaaagttcag                                                   20


<210> 18318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18318
aaagggaaag aaaaagttca                                                   20


<210> 18319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18319
gaaagggaaa gaaaaagttc                                                   20


<210> 18320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18320
tgaaagggaa agaaaaagtt                                                   20


<210> 18321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18321
gaacatgaaa gggaaagaaa                                                   20


<210> 18322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18322
tatggtgaac atgaaaggga                                                   20


<210> 18323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18323
cctttatggt gaacatgaaa                                                   20


<210> 18324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18324
acctttatgg tgaacatgaa                                                   20


<210> 18325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18325
gacctttatg gtgaacatga                                                   20


<210> 18326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18326
tcttcagtta gtgaccttta                                                   20


<210> 18327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18327
gtgatgtcac catcttcagt                                                   20


<210> 18328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18328
tatcgtgatg tcaccatctt                                                   20


<210> 18329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18329
aagtagcgcc tcaaggatct                                                   20


<210> 18330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18330
caagtagcgc ctcaaggatc                                                   20


<210> 18331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18331
ctacttcaag tagcgcctca                                                   20


<210> 18332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18332
tctacttcaa gtagcgcctc                                                   20


<210> 18333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18333
ctgggagtgt ctacttcaag                                                   20


<210> 18334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18334
ctcctgggag tgtctacttc                                                   20


<210> 18335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18335
ttgttgggaa gctctcctgg                                                   20


<210> 18336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18336
gcttgttggg aagctctcct                                                   20


<210> 18337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18337
tgcttgttgg gaagctctcc                                                   20


<210> 18338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18338
cacattcagt gcttgttggg                                                   20


<210> 18339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18339
cagcacattc agtgcttgtt                                                   20


<210> 18340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18340
acagcacatt cagtgcttgt                                                   20


<210> 18341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18341
tgtatgtctc acagcacatt                                                   20


<210> 18342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18342
taatagagat gtatgtctca                                                   20


<210> 18343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18343
atctgtgagt taacataata                                                   20


<210> 18344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18344
aaatctgtga gttaacataa                                                   20


<210> 18345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18345
gtgataccct ctaaatctgt                                                   20


<210> 18346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18346
aagataagta caactagctg                                                   20


<210> 18347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18347
ttactcaaga taagtacaac                                                   20


<210> 18348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18348
atttctccat tactcaagat                                                   20


<210> 18349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18349
aagcaatttc tccattactc                                                   20


<210> 18350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18350
ggcaatacct tttttcaatg                                                   20


<210> 18351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18351
catagttgat gcttttgaaa                                                   20


<210> 18352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18352
acatagttga tgcttttgaa                                                   20


<210> 18353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18353
atcattaagc cagtgccaca                                                   20


<210> 18354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18354
ccaccacatg atcattaagc                                                   20


<210> 18355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18355
ttgcccacca catgatcatt                                                   20


<210> 18356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18356
cattccaagc cttctcctat                                                   20


<210> 18357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18357
ataacataga ttgacattcc                                                   20


<210> 18358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18358
atttttgtca ctgaataaca                                                   20


<210> 18359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18359
ctctgcctca aaatttttgc                                                   20


<210> 18360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18360
cctagggttg ctggttcatg                                                   20


<210> 18361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18361
ccctagggtt gctggttcat                                                   20


<210> 18362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18362
aacccttccc ctagggttgc                                                   20


<210> 18363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18363
tttaataaac ccttccccta                                                   20


<210> 18364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18364
gtttaataaa cccttcccct                                                   20


<210> 18365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18365
ggtttaataa acccttcccc                                                   20


<210> 18366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18366
acaactgacc cacaatacta                                                   20


<210> 18367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18367
tacaactgac ccacaatact                                                   20


<210> 18368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18368
ttgtactgtc ttgaccaaca                                                   20


<210> 18369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18369
aaaccagcta aatctttcct                                                   20


<210> 18370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18370
tttcttttat tcttataaac                                                   20


<210> 18371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18371
tcgtcaaggc tctaaacttc                                                   20


<210> 18372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18372
tacagttccc taaatcgtca                                                   20


<210> 18373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18373
gtacagttcc ctaaatcgtc                                                   20


<210> 18374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18374
cctggaatct agaagcagta                                                   20


<210> 18375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18375
cactgcctgg aatctagaag                                                   20


<210> 18376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18376
gctcactgcc tggaatctag                                                   20


<210> 18377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18377
attgctcact gcctggaatc                                                   20


<210> 18378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18378
taatcccatt gctcactgcc                                                   20


<210> 18379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18379
taactagtct tcaacatttg                                                   20


<210> 18380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18380
atttaattgg aaaatttaac                                                   20


<210> 18381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18381
taagagttgt ttcatttaat                                                   20


<210> 18382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18382
attactacaa gctttgctaa                                                   20


<210> 18383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18383
ccattactac aagctttgct                                                   20


<210> 18384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18384
agtggctaca ccattactac                                                   20


<210> 18385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18385
ttctcttgca caagaaacag                                                   20


<210> 18386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18386
cctttctctt gcacaagaaa                                                   20


<210> 18387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18387
cccatgcctt tctcttgcac                                                   20


<210> 18388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18388
acaaagtgct ttctttgaca                                                   20


<210> 18389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18389
agacctctca ttgccacaca                                                   20


<210> 18390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18390
ttcaaaaact tagatggctt                                                   20


<210> 18391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18391
aattacttca aaaacttaga                                                   20


<210> 18392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18392
atacaattac ttcaaaaact                                                   20


<210> 18393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18393
gtgaaaggct ttttcagtca                                                   20


<210> 18394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18394
agtgaaaggc tttttcagtc                                                   20


<210> 18395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18395
cagtgaaagg ctttttcagt                                                   20


<210> 18396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18396
taaacagtga aaggcttttt                                                   20


<210> 18397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18397
tttaaggttt aaacagtgaa                                                   20


<210> 18398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18398
ttttaaggtt taaacagtga                                                   20


<210> 18399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18399
ggtttgtttt aaggtttaaa                                                   20


<210> 18400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18400
gaaagccaag gtttgtttta                                                   20


<210> 18401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18401
ggaaagccaa ggtttgtttt                                                   20


<210> 18402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18402
tgtgggaaaa tggaaagcca                                                   20


<210> 18403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18403
ttgtgggaaa atggaaagcc                                                   20


<210> 18404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18404
cctgcttgtg ggaaaatgga                                                   20


<210> 18405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18405
gcctcctgct tgtgggaaaa                                                   20


<210> 18406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18406
aaagtttgcc tcctgcttgt                                                   20


<210> 18407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18407
caaagtttgc ctcctgcttg                                                   20


<210> 18408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18408
aggaggccaa tataacttca                                                   20


<210> 18409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18409
gactttgcca tgcctgaagg                                                   20


<210> 18410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18410
tgactttgcc atgcctgaag                                                   20


<210> 18411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18411
agtgactttg ccatgcctga                                                   20


<210> 18412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18412
aagtgacttt gccatgcctg                                                   20


<210> 18413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18413
gctctaggtg ggactccaag                                                   20


<210> 18414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18414
acagctctag gtgggactcc                                                   20


<210> 18415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18415
caagccagac agctctaggt                                                   20


<210> 18416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18416
gcaagccaga cagctctagg                                                   20


<210> 18417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18417
aatgcaagcc agacagctct                                                   20


<210> 18418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18418
taatgcaagc cagacagctc                                                   20


<210> 18419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18419
atagcctaat gcaagccaga                                                   20


<210> 18420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18420
tatcatagcc taatgcaagc                                                   20


<210> 18421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18421
ctcgtatcat agcctaatgc                                                   20


<210> 18422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18422
tttatttctc actcgtatca                                                   20


<210> 18423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18423
tgagtaactg accccaataa                                                   20


<210> 18424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18424
ctgagtaact gaccccaata                                                   20


<210> 18425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18425
tacagacaat ctctaaaact                                                   20


<210> 18426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18426
aaataaagct acctattata                                                   20


<210> 18427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18427
ttattaatca atgaaaaata                                                   20


<210> 18428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18428
tcccaattta ttgtaatgat                                                   20


<210> 18429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18429
tccaagacaa cttttcattc                                                   20


<210> 18430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18430
aaaatcttta accttcctcc                                                   20


<210> 18431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18431
acttaatcaa agccaaaagt                                                   20


<210> 18432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18432
gttaacttaa tcaaagccaa                                                   20


<210> 18433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18433
tccattagtt aacttaatca                                                   20


<210> 18434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18434
agcataaatt aactctccat                                                   20


<210> 18435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18435
ggtcgtggct gcagaaatta                                                   20


<210> 18436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18436
agcccaggag gtcgtggctg                                                   20


<210> 18437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18437
gacttgagcc caggaggtcg                                                   20


<210> 18438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18438
gaggatgact tgagcccagg                                                   20


<210> 18439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18439
ggaggatgac ttgagcccag                                                   20


<210> 18440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18440
tgggaggatg acttgagccc                                                   20


<210> 18441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18441
gtgggaggat gacttgagcc                                                   20


<210> 18442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18442
ctgaggtggg aggatgactt                                                   20


<210> 18443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18443
atttgggagg ctgaggtggg                                                   20


<210> 18444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18444
tatttgggag gctgaggtgg                                                   20


<210> 18445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18445
gctatttggg aggctgaggt                                                   20


<210> 18446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18446
agctatttgg gaggctgagg                                                   20


<210> 18447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18447
ctcagctatt tgggaggctg                                                   20


<210> 18448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18448
tctcagctat ttgggaggct                                                   20


<210> 18449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18449
tgtagtctca gctatttggg                                                   20


<210> 18450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18450
ctgtagtctc agctatttgg                                                   20


<210> 18451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18451
gtctgtagtc tcagctattt                                                   20


<210> 18452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18452
tgtctgtagt ctcagctatt                                                   20


<210> 18453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18453
atggcacgtg tctgtagtct                                                   20


<210> 18454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18454
ggcatgatgg cacgtgtctg                                                   20


<210> 18455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18455
aagaaattag ctgggcatga                                                   20


<210> 18456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18456
gaaaaggaaa gaaattagct                                                   20


<210> 18457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18457
agaaaaggaa agaaattagc                                                   20


<210> 18458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18458
aaaaagaaaa ggaaagaaat                                                   20


<210> 18459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18459
aaatttaaaa aagaaaagga                                                   20


<210> 18460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18460
ttttaaattt aaaaaagaaa                                                   20


<210> 18461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18461
attttaaatt taaaaaagaa                                                   20


<210> 18462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18462
aataaatttt aaatttaaaa                                                   20


<210> 18463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18463
cactccagcc tgggcaacaa                                                   20


<210> 18464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18464
gcactccagc ctgggcaaca                                                   20


<210> 18465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18465
tgcactccag cctgggcaac                                                   20


<210> 18466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18466
gcaccattgc actccagcct                                                   20


<210> 18467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18467
tgcaccattg cactccagcc                                                   20


<210> 18468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18468
gagattgcac cattgcactc                                                   20


<210> 18469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18469
ggcggaggtt gcggtgagct                                                   20


<210> 18470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18470
cgggaggcgg aggttgcggt                                                   20


<210> 18471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18471
aacccgggag gcggaggttg                                                   20


<210> 18472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18472
tgcttgaacc cgggaggcgg                                                   20


<210> 18473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18473
ttgcttgaac ccgggaggcg                                                   20


<210> 18474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18474
aattgcttga acccgggagg                                                   20


<210> 18475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18475
gagaattgct tgaacccggg                                                   20


<210> 18476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18476
ggagaattgc ttgaacccgg                                                   20


<210> 18477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18477
gaggagaatt gcttgaaccc                                                   20


<210> 18478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18478
ggaggagaat tgcttgaacc                                                   20


<210> 18479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18479
tacttgggag gctgagggag                                                   20


<210> 18480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18480
gctacttggg aggctgaggg                                                   20


<210> 18481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18481
agctacttgg gaggctgagg                                                   20


<210> 18482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18482
ccagctactt gggaggctga                                                   20


<210> 18483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18483
cccagctact tgggaggctg                                                   20


<210> 18484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18484
tcccagctac ttgggaggct                                                   20


<210> 18485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18485
tttaatccca gctacttggg                                                   20


<210> 18486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18486
ttttaatccc agctacttgg                                                   20


<210> 18487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18487
acttttaatc ccagctactt                                                   20


<210> 18488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18488
tacttttaat cccagctact                                                   20


<210> 18489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18489
atggtgcata cttttaatcc                                                   20


<210> 18490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18490
acaaaattag ccaggtgtga                                                   20


<210> 18491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18491
ccaaaaatac aaaattagcc                                                   20


<210> 18492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18492
accaaaaata caaaattagc                                                   20


<210> 18493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18493
ctctaccaaa aatacaaaat                                                   20


<210> 18494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18494
ccagcctgac caacatggag                                                   20


<210> 18495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18495
agaccagcct gaccaacatg                                                   20


<210> 18496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18496
cgagaccagc ctgaccaaca                                                   20


<210> 18497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18497
tgaggtcggg agttcgagac                                                   20


<210> 18498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18498
tcacctgagg tcgggagttc                                                   20


<210> 18499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18499
ggcggatcac ctgaggtcgg                                                   20


<210> 18500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18500
caggcggatc acctgaggtc                                                   20


<210> 18501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18501
gcaggcggat cacctgaggt                                                   20


<210> 18502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18502
gcaggcaggc ggatcacctg                                                   20


<210> 18503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18503
cgcaggcagg cggatcacct                                                   20


<210> 18504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18504
ctgttggagg cgcaggcagg                                                   20


<210> 18505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18505
gcactgttgg aggcgcaggc                                                   20


<210> 18506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18506
agcactgttg gaggcgcagg                                                   20


<210> 18507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18507
cccagcactg ttggaggcgc                                                   20


<210> 18508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18508
tcccagcact gttggaggcg                                                   20


<210> 18509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18509
tgtaatccca gcactgttgg                                                   20


<210> 18510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18510
ctgtaatccc agcactgttg                                                   20


<210> 18511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18511
gcctgtaatc ccagcactgt                                                   20


<210> 18512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18512
gtggttaatg cctgtaatcc                                                   20


<210> 18513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18513
aaaaagaagg ccaggggcag                                                   20


<210> 18514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18514
aataaaaaga aggccagggg                                                   20


<210> 18515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18515
aacaataaaa agaaggccag                                                   20


<210> 18516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18516
aaacaataaa aagaaggcca                                                   20


<210> 18517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18517
aaaacaataa aaagaaggcc                                                   20


<210> 18518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18518
gaaaacaata aaaagaaggc                                                   20


<210> 18519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18519
cattgaaaac aataaaaaga                                                   20


<210> 18520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18520
tcattgaaaa caataaaaag                                                   20


<210> 18521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18521
gtctcattga aaacaataaa                                                   20


<210> 18522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18522
tccagcctgg gcaacagagc                                                   20


<210> 18523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18523
gcactccagc ctgggcaaca                                                   20


<210> 18524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18524
ctgcactcca gcctgggcaa                                                   20


<210> 18525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18525
atgccactgc actccagcct                                                   20


<210> 18526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18526
catgccactg cactccagcc                                                   20


<210> 18527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18527
gagatcatgc cactgcactc                                                   20


<210> 18528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18528
gacagaggtt gcagtgagct                                                   20


<210> 18529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18529
ccagagacag aggttgcagt                                                   20


<210> 18530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18530
aatcccagag acagaggttg                                                   20


<210> 18531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18531
tgcttgaatc ccagagacag                                                   20


<210> 18532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18532
ttgcttgaat cccagagaca                                                   20


<210> 18533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18533
aattgcttga atcccagaga                                                   20


<210> 18534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18534
tgagaattgc ttgaatccca                                                   20


<210> 18535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18535
catgagaatt gcttgaatcc                                                   20


<210> 18536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18536
tactcaggag ggtgaggcat                                                   20


<210> 18537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18537
cccagctact caggagggtg                                                   20


<210> 18538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18538
tcccagctac tcaggagggt                                                   20


<210> 18539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18539
gtaatcccag ctactcagga                                                   20


<210> 18540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18540
tgtaatccca gctactcagg                                                   20


<210> 18541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18541
ctgtaatccc agctactcag                                                   20


<210> 18542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18542
acctgtaatc ccagctactc                                                   20


<210> 18543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18543
cacctgtaat cccagctact                                                   20


<210> 18544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18544
gtggcacaca cctgtaatcc                                                   20


<210> 18545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18545
tataaattag ctgggtgtgg                                                   20


<210> 18546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18546
atatataaat tagctgggtg                                                   20


<210> 18547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18547
taaaaatata taaattagct                                                   20


<210> 18548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18548
ctaaaaatat ataaattagc                                                   20


<210> 18549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18549
tctactaaaa atatataaat                                                   20


<210> 18550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18550
gagaccagcc tggccaacag                                                   20


<210> 18551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18551
tggagaccag cctggccaac                                                   20


<210> 18552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18552
ttggagacca gcctggccaa                                                   20


<210> 18553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18553
acaggagttg gagaccagcc                                                   20


<210> 18554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18554
tgaggacagg agttggagac                                                   20


<210> 18555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18555
ttgcttgagg acaggagttg                                                   20


<210> 18556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18556
gattgcttga ggacaggagt                                                   20


<210> 18557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18557
ggaggattgc ttgaggacag                                                   20


<210> 18558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18558
tgggaggatt gcttgaggac                                                   20


<210> 18559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18559
gtgggaggat tgcttgagga                                                   20


<210> 18560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18560
caaggtggga ggattgcttg                                                   20


<210> 18561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18561
ccaaggtggg aggattgctt                                                   20


<210> 18562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18562
ttttgggagg ccaaggtggg                                                   20


<210> 18563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18563
attttgggag gccaaggtgg                                                   20


<210> 18564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18564
gaattttggg aggccaaggt                                                   20


<210> 18565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18565
agaattttgg gaggccaagg                                                   20


<210> 18566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18566
cccagaattt tgggaggcca                                                   20


<210> 18567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18567
tcccagaatt ttgggaggcc                                                   20


<210> 18568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18568
tgtaatccca gaattttggg                                                   20


<210> 18569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18569
ctgtaatccc agaattttgg                                                   20


<210> 18570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18570
gcctgtaatc ccagaatttt                                                   20


<210> 18571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18571
cgcctgtaat cccagaattt                                                   20


<210> 18572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18572
gtggctcacg cctgtaatcc                                                   20


<210> 18573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18573
gccaaggggg ccaggtgggg                                                   20


<210> 18574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18574
aaagccaagg gggccaggtg                                                   20


<210> 18575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18575
taaagccaag ggggccaggt                                                   20


<210> 18576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18576
ttaaagccaa gggggccagg                                                   20


<210> 18577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18577
tttttaaagc caagggggcc                                                   20


<210> 18578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18578
ttttttaaag ccaagggggc                                                   20


<210> 18579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18579
tttttttttt aaagccaagg                                                   20


<210> 18580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18580
attttttttt taaagccaag                                                   20


<210> 18581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18581
catttttttt ttaaagccaa                                                   20


<210> 18582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18582
ccattttttt tttaaagcca                                                   20


<210> 18583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18583
gccatttttt ttttaaagcc                                                   20


<210> 18584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18584
attatgccat ttttttttta                                                   20


<210> 18585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18585
ggttttggta tcaaggttcc                                                   20


<210> 18586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18586
cttgccaggt tttggtatca                                                   20


<210> 18587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18587
ccttgccagg ttttggtatc                                                   20


<210> 18588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18588
tcattgtcct tgccaggttt                                                   20


<210> 18589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18589
tgactttcat tgtccttgcc                                                   20


<210> 18590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18590
ctgactttca ttgtccttgc                                                   20


<210> 18591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18591
atttttttat ccatatcaat                                                   20


<210> 18592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18592
agtttgctaa aaatttgctt                                                   20


<210> 18593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18593
ttttaataca ttggaagatt                                                   20


<210> 18594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18594
tgcatttttt aatacattgg                                                   20


<210> 18595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18595
tgatgcattt tttaatacat                                                   20


<210> 18596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18596
ttacattccc agctcaaacc                                                   20


<210> 18597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18597
ttaaatcaac tttacattcc                                                   20


<210> 18598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18598
tctccttcaa tctgttaaag                                                   20


<210> 18599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18599
ttttctcctt caatctgtta                                                   20


<210> 18600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18600
acaattattc tacatgtatt                                                   20


<210> 18601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18601
gaatggatgt ttaattttat                                                   20


<210> 18602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18602
tcaagaatat ttatcatgaa                                                   20


<210> 18603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18603
tcaggaagtt ctcttttatc                                                   20


<210> 18604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18604
gaaatcttta tcagttcagg                                                   20


<210> 18605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18605
taagaaatct ttatcagttc                                                   20


<210> 18606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18606
ataagaaatc tttatcagtt                                                   20


<210> 18607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18607
taaagataag aaatctttat                                                   20


<210> 18608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18608
ggcaggcttt ttttaaagat                                                   20


<210> 18609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18609
attgtggcag gcttttttta                                                   20


<210> 18610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18610
ccacctctaa caattgtggc                                                   20


<210> 18611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18611
accacctcta acaattgtgg                                                   20


<210> 18612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18612
ttcaccacct ctaacaattg                                                   20


<210> 18613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18613
atcaattttc tgatcccaaa                                                   20


<210> 18614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18614
tgaaaagaag tgttaataac                                                   20


<210> 18615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18615
ttgaaaagaa gtgttaataa                                                   20


<210> 18616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18616
tccagtacac tgttgaaaag                                                   20


<210> 18617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18617
acatccagta cactgttgaa                                                   20


<210> 18618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18618
actgtgctag ttaggacatc                                                   20


<210> 18619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18619
actagatcac tgtgctagtt                                                   20


<210> 18620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18620
tactagatca ctgtgctagt                                                   20


<210> 18621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18621
tttttactag atcactgtgc                                                   20


<210> 18622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18622
tgccattagg ttctttttac                                                   20


<210> 18623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18623
tttctaatcc ttatgccatt                                                   20


<210> 18624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18624
ttttctaatc cttatgccat                                                   20


<210> 18625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18625
aggcatgagc cacccacgcc                                                   20


<210> 18626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18626
agtgctggga ttacaggcat                                                   20


<210> 18627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18627
tcctaaagtg ctgggattac                                                   20


<210> 18628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18628
ctcctaaagt gctgggatta                                                   20


<210> 18629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18629
ccttggcctc ctaaagtgct                                                   20


<210> 18630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18630
gccttggcct cctaaagtgc                                                   20


<210> 18631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18631
ctgcctgcct tggcctccta                                                   20


<210> 18632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18632
acctcatgat ctgcctgcct                                                   20


<210> 18633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18633
tttcaccgtg ttagccagga                                                   20


<210> 18634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18634
ggggtttcac cgtgttagcc                                                   20


<210> 18635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18635
cggggtttca ccgtgttagc                                                   20


<210> 18636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18636
gagacggggt ttcaccgtgt                                                   20


<210> 18637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18637
ttgtattttt agtagagacg                                                   20


<210> 18638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18638
tttgtatttt tagtagagac                                                   20


<210> 18639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18639
ctttgtattt ttagtagaga                                                   20


<210> 18640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18640
aattctttgt atttttagta                                                   20


<210> 18641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18641
ctaattcttt gtatttttag                                                   20


<210> 18642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18642
tggctaattc tttgtatttt                                                   20


<210> 18643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18643
caggcaccca ccaccatgcc                                                   20


<210> 18644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18644
tcctgagtag ctgggactac                                                   20


<210> 18645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18645
ctcctgagta gctgggacta                                                   20


<210> 18646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18646
cctcagcctc ctgagtagct                                                   20


<210> 18647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18647
gcctcagcct cctgagtagc                                                   20


<210> 18648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18648
tcctgcctca gcctcctgag                                                   20


<210> 18649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18649
ttctcctgcc tcagcctcct                                                   20


<210> 18650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18650
ttcacgccat tctcctgcct                                                   20


<210> 18651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18651
cattgccagc tccacctccc                                                   20


<210> 18652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18652
tcattgccag ctccacctcc                                                   20


<210> 18653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18653
gcgtgatctc ggctcattgc                                                   20


<210> 18654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18654
agagtgcagt ggcgtgatct                                                   20


<210> 18655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18655
tcacccaggc tagagtgcag                                                   20


<210> 18656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18656
ctgtcaccca ggctagagtg                                                   20


<210> 18657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18657
tcgctctgtc acccaggcta                                                   20


<210> 18658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18658
tctcgctctg tcacccaggc                                                   20


<210> 18659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18659
agagtctcgc tctgtcaccc                                                   20


<210> 18660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18660
cagagtctcg ctctgtcacc                                                   20


<210> 18661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18661
tttttttttt ttttgagaca                                                   20


<210> 18662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18662
tttttttttt ttttttgaga                                                   20


<210> 18663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18663
tttttttttt tttttttttt                                                   20


<210> 18664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18664
catcatgtga aaataacaat                                                   20


<210> 18665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18665
atatttaaca tttttgtatc                                                   20


<210> 18666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18666
tcttttctgg catttttggc                                                   20


<210> 18667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18667
atgttctttt ctggcatttt                                                   20


<210> 18668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18668
tcttcttaaa tgttcttttc                                                   20


<210> 18669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18669
gtttttataa ttttctccat                                                   20


<210> 18670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18670
ggtttttata attttctcca                                                   20


<210> 18671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18671
agtttaaaaa tgtttccatg                                                   20


<210> 18672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18672
aagtttaaaa atgtttccat                                                   20


<210> 18673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18673
tgtataccag tctttcaata                                                   20


<210> 18674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18674
agatagtata cgctgtatac                                                   20


<210> 18675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18675
agtcttctga tctatgaaga                                                   20


<210> 18676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18676
attcagtctt ctgatctatg                                                   20


<210> 18677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18677
cttataatct ttacataatt                                                   20


<210> 18678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18678
aattgatagg tcaatttggg                                                   20


<210> 18679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18679
tgtaattgat aggtcaattt                                                   20


<210> 18680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18680
ctgtaattga taggtcaatt                                                   20


<210> 18681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18681
tagggactgc tgtaattgat                                                   20


<210> 18682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18682
ttagggactg ctgtaattga                                                   20


<210> 18683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18683
tgctattgtt tttcccatta                                                   20


<210> 18684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18684
ctgctattgt ttttcccatt                                                   20


<210> 18685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18685
actgctattg tttttcccat                                                   20


<210> 18686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18686
cactttagaa ttatcttgcc                                                   20


<210> 18687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18687
gcacactttc atattcactt                                                   20


<210> 18688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18688
aatttacttc aagaatatct                                                   20


<210> 18689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18689
taatccacct aatttacttc                                                   20


<210> 18690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18690
tatatctgtg tctgtaaatc                                                   20


<210> 18691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18691
aatatcagtc ttaattatgg                                                   20


<210> 18692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18692
accaatatca gtcttaatta                                                   20


<210> 18693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18693
gtctatcctg gcaccaatat                                                   20


<210> 18694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18694
gttagtccat tggtctatcc                                                   20


<210> 18695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18695
catttgctct gttagtccat                                                   20


<210> 18696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18696
ccttgctcca tttgctctgt                                                   20


<210> 18697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18697
gcttctcctc ccgtcactta                                                   20


<210> 18698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18698
gtcttccttc tctcccaaaa                                                   20


<210> 18699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18699
gggaaaaagg aagaaataaa                                                   20


<210> 18700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18700
ggaaggtgga gggaaaaagg                                                   20


<210> 18701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18701
agaggaaggt ggagggaaaa                                                   20


<210> 18702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18702
gagaggaagg tggagggaaa                                                   20


<210> 18703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18703
aagaaagaga ggaaggtgga                                                   20


<210> 18704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18704
aaagaaagag aggaaggtgg                                                   20


<210> 18705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18705
gaaagaaaga gaggaaggtg                                                   20


<210> 18706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18706
aggaaagaaa gagaggaagg                                                   20


<210> 18707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18707
ggaaggaaag aaagagagga                                                   20


<210> 18708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18708
aggaaggaaa gaaagagagg                                                   20


<210> 18709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18709
tgaaggaagg aaagaaagag                                                   20


<210> 18710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18710
ttgaaggaag gaaagaaaga                                                   20


<210> 18711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18711
gattgaagga aggaaagaaa                                                   20


<210> 18712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18712
ttgattgaag gaaggaaaga                                                   20


<210> 18713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18713
ttgattgatt gaaggaagga                                                   20


<210> 18714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18714
cctgttgatt gattgaagga                                                   20


<210> 18715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18715
acctgttgat tgattgaagg                                                   20


<210> 18716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18716
aacacctgtt gattgattga                                                   20


<210> 18717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18717
aaacacctgt tgattgattg                                                   20


<210> 18718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18718
acaaggccca gcacatacat                                                   20


<210> 18719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18719
cacaaggccc agcacataca                                                   20


<210> 18720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18720
caagggccta gcacaaggcc                                                   20


<210> 18721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18721
tatcccaagg gcctagcaca                                                   20


<210> 18722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18722
ttatcccaag ggcctagcac                                                   20


<210> 18723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18723
accgttttat cccaagggcc                                                   20


<210> 18724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18724
tgtctaccgt tttatcccaa                                                   20


<210> 18725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18725
ttgtctaccg ttttatccca                                                   20


<210> 18726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18726
cttgtctacc gttttatccc                                                   20


<210> 18727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18727
atcccatgag gcaaaaacca                                                   20


<210> 18728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18728
ctatcccatg aggcaaaaac                                                   20


<210> 18729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18729
aattgtcctg ctatcccatg                                                   20


<210> 18730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18730
caattgtcct gctatcccat                                                   20


<210> 18731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18731
attccttcat caaattaacc                                                   20


<210> 18732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18732
ccaaccacac tatctaaagt                                                   20


<210> 18733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18733
ctccccaacc acactatcta                                                   20


<210> 18734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18734
cacttgtcac ctccttagag                                                   20


<210> 18735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18735
gcacttgtca cctccttaga                                                   20


<210> 18736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18736
tgcacttgtc acctccttag                                                   20


<210> 18737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18737
atgcacttgt cacctcctta                                                   20


<210> 18738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18738
caatgcactt gtcacctcct                                                   20


<210> 18739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18739
cttttccttt agtcttcact                                                   20


<210> 18740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18740
tgcctggaat acttttcctt                                                   20


<210> 18741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18741
gaagtttttt tcgctgtgcc                                                   20


<210> 18742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18742
ttcttggctt tgggcctttg                                                   20


<210> 18743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18743
acagagaact tcttggcttt                                                   20


<210> 18744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18744
aacagagaac ttcttggctt                                                   20


<210> 18745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18745
acacataaca gagaacttct                                                   20


<210> 18746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18746
tctcttcttc acacataaca                                                   20


<210> 18747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18747
tctctcttct tcacacataa                                                   20


<210> 18748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18748
ccactttgct ccagccaaaa                                                   20


<210> 18749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18749
cccactttgc tccagccaaa                                                   20


<210> 18750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18750
ccgtcttgcc cactttgctc                                                   20


<210> 18751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18751
atcaggacct gccagttcac                                                   20


<210> 18752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18752
tctgcataat caggacctgc                                                   20


<210> 18753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18753
gtacaaagtt ctgcataatc                                                   20


<210> 18754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18754
tgtacaaagt tctgcataat                                                   20


<210> 18755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18755
actcctcatg atggtgtaca                                                   20


<210> 18756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18756
aaaatccaga ctcctcatga                                                   20


<210> 18757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18757
attgctctga gaataaaatc                                                   20


<210> 18758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18758
cactggtttc ccattgctct                                                   20


<210> 18759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18759
tttgttacaa ataacttcac                                                   20


<210> 18760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18760
ctattaccaa catcttatgt                                                   20


<210> 18761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18761
cacacacaca cacacacaca                                                   20


<210> 18762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18762
cacacacaca cacacacaca                                                   20


<210> 18763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18763
actggagcag attgaacaga                                                   20


<210> 18764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18764
gaaaactgga gcagattgaa                                                   20


<210> 18765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18765
cagttttcag aaaactggag                                                   20


<210> 18766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18766
tttcagtttt cagaaaactg                                                   20


<210> 18767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18767
gttttcagtt ttcagaaaac                                                   20


<210> 18768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18768
tcaggacagt tttcagtttt                                                   20


<210> 18769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18769
tttattttca ggacagtttt                                                   20


<210> 18770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18770
aatagacttt attttcagga                                                   20


<210> 18771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18771
aattaataga ctttattttc                                                   20


<210> 18772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18772
taattaatag actttatttt                                                   20


<210> 18773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18773
agtttcctgg ttttaattaa                                                   20


<210> 18774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18774
ccgccagctg gtcagtttcc                                                   20


<210> 18775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18775
aaaaatcacc gccagctggt                                                   20


<210> 18776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18776
ggagaaaaat caccgccagc                                                   20


<210> 18777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18777
tgctggagaa aaatcaccgc                                                   20


<210> 18778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18778
ctgagctgtg agaaatgctg                                                   20


<210> 18779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18779
acctgagctg tgagaaatgc                                                   20


<210> 18780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18780
cttgtctgca cctgagctgt                                                   20


<210> 18781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18781
tctccacctt gtctgcacct                                                   20


<210> 18782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18782
aaaacctcac cggagagtct                                                   20


<210> 18783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18783
tttgccaaaa cctcaccgga                                                   20


<210> 18784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18784
tgtttgccaa aacctcaccg                                                   20


<210> 18785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18785
tgtgtttgcc aaaacctcac                                                   20


<210> 18786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18786
atgacctagc ttagatttca                                                   20


<210> 18787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18787
acttccctca tgacctagct                                                   20


<210> 18788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18788
attccacttc cctcatgacc                                                   20


<210> 18789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18789
caccaactac acactttctt                                                   20


<210> 18790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18790
ccaccaacta cacactttct                                                   20


<210> 18791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18791
cgctgattta acatgctgat                                                   20


<210> 18792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18792
gcccctacag gattctgcag                                                   20


<210> 18793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18793
tgcccctaca ggattctgca                                                   20


<210> 18794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18794
ctgcccctac aggattctgc                                                   20


<210> 18795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18795
tctgccccta caggattctg                                                   20


<210> 18796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18796
acttcacagt ctgcccctac                                                   20


<210> 18797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18797
tacttcacag tctgccccta                                                   20


<210> 18798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18798
aaataggcaa gtttacttca                                                   20


<210> 18799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18799
ccaaacaacc aaaaataggc                                                   20


<210> 18800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18800
agtcccaaac aaccaaaaat                                                   20


<210> 18801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18801
aagtcccaaa caaccaaaaa                                                   20


<210> 18802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18802
tgttctgatc ccacagtcta                                                   20


<210> 18803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18803
ctacttttgt tctgatccca                                                   20


<210> 18804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18804
agcagaagct tagtgtttta                                                   20


<210> 18805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18805
aagcagaagc ttagtgtttt                                                   20


<210> 18806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18806
cacttgggga agcagaagct                                                   20


<210> 18807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18807
tgctacactt ggggaagcag                                                   20


<210> 18808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18808
ttctgctaca cttggggaag                                                   20


<210> 18809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18809
catttctgct acacttgggg                                                   20


<210> 18810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18810
gaacatttct gctacacttg                                                   20


<210> 18811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18811
cgaacatttc tgctacactt                                                   20


<210> 18812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18812
acgaacattt ctgctacact                                                   20


<210> 18813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18813
tccggcctgg gctaaacagc                                                   20


<210> 18814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18814
atccggcctg ggctaaacag                                                   20


<210> 18815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18815
gcaatccggc ctgggctaaa                                                   20


<210> 18816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18816
gcgccactgc aatccggcct                                                   20


<210> 18817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18817
tgcgccactg caatccggcc                                                   20


<210> 18818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18818
gagattgcgc cactgcaatc                                                   20


<210> 18819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18819
ggcggagctt acagtgagcc                                                   20


<210> 18820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18820
tgggaggcgg agcttacagt                                                   20


<210> 18821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18821
aacctgggag gcggagctta                                                   20


<210> 18822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18822
tggcgtgaac ctgggaggcg                                                   20


<210> 18823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18823
aatggcgtga acctgggagg                                                   20


<210> 18824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18824
gagaatggcg tgaacctggg                                                   20


<210> 18825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18825
ggagaatggc gtgaacctgg                                                   20


<210> 18826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18826
caggagaatg gcgtgaacct                                                   20


<210> 18827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18827
gcaggagaat ggcgtgaacc                                                   20


<210> 18828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18828
gggaggctga ggcaggagaa                                                   20


<210> 18829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18829
tactcgggag gctgaggcag                                                   20


<210> 18830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18830
gctactcggg aggctgaggc                                                   20


<210> 18831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18831
agctactcgg gaggctgagg                                                   20


<210> 18832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18832
cccagctact cgggaggctg                                                   20


<210> 18833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18833
tcccagctac tcgggaggct                                                   20


<210> 18834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18834
tgtagtccca gctactcggg                                                   20


<210> 18835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18835
ctgtagtccc agctactcgg                                                   20


<210> 18836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18836
gcctgtagtc ccagctactc                                                   20


<210> 18837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18837
cgcctgtagt cccagctact                                                   20


<210> 18838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18838
gtggcgggcg cctgtagtcc                                                   20


<210> 18839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18839
ggcacggtgg cgggcgcctg                                                   20


<210> 18840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18840
aattagccgg gcacggtggc                                                   20


<210> 18841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18841
aaattagccg ggcacggtgg                                                   20


<210> 18842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18842
aaaaaattag ccgggcacgg                                                   20


<210> 18843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18843
tacaaaaaat tagccgggca                                                   20


<210> 18844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18844
aaaaatacaa aaaattagcc                                                   20


<210> 18845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18845
taaaaataca aaaaattagc                                                   20


<210> 18846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18846
ctactaaaaa tacaaaaaat                                                   20


<210> 18847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18847
cgagaccatc ttggctaaca                                                   20


<210> 18848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18848
tcaggagatc gagaccatct                                                   20


<210> 18849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18849
gatcacaagg tcaggagatc                                                   20


<210> 18850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18850
caggcggatc acaaggtcag                                                   20


<210> 18851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18851
ggcaggcgga tcacaaggtc                                                   20


<210> 18852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18852
aggcaggcgg atcacaaggt                                                   20


<210> 18853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18853
gccgaggcag gcggatcaca                                                   20


<210> 18854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18854
ggccgaggca ggcggatcac                                                   20


<210> 18855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18855
ctttgggagg ccgaggcagg                                                   20


<210> 18856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18856
gcactttggg aggccgaggc                                                   20


<210> 18857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18857
agcactttgg gaggccgagg                                                   20


<210> 18858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18858
cccagcactt tgggaggccg                                                   20


<210> 18859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18859
tcccagcact ttgggaggcc                                                   20


<210> 18860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18860
tgtaatccca gcactttggg                                                   20


<210> 18861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18861
ctgtaatccc agcactttgg                                                   20


<210> 18862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18862
gcctgtaatc ccagcacttt                                                   20


<210> 18863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18863
cgcctgtaat cccagcactt                                                   20


<210> 18864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18864
gtggctcacg cctgtaatcc                                                   20


<210> 18865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18865
aaatacgagg ctgggcgcgg                                                   20


<210> 18866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 18866
ataaaatacg aggctgggcg                                                   20


<210> 18867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18867
ttctaataaa atacgaggct                                                   20


<210> 18868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18868
tttctaataa aatacgaggc                                                   20


<210> 18869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18869
tagttttcta ataaaatacg                                                   20


<210> 18870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18870
ttagttttct aataaaatac                                                   20


<210> 18871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18871
taccctggca ggcccacagt                                                   20


<210> 18872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18872
cccataccct ggcaggccca                                                   20


<210> 18873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18873
tcacaccccc ataccctggc                                                   20


<210> 18874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18874
atcacacccc cataccctgg                                                   20


<210> 18875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18875
gatatcacac ccccataccc                                                   20


<210> 18876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18876
cacaatcgtc aagagagcag                                                   20


<210> 18877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18877
tgcacaatcg tcaagagagc                                                   20


<210> 18878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18878
atgcacaatc gtcaagagag                                                   20


<210> 18879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18879
cctatgcaca atcgtcaaga                                                   20


<210> 18880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18880
tacctatgca caatcgtcaa                                                   20


<210> 18881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18881
ggtacctatg cacaatcgtc                                                   20


<210> 18882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18882
ctaagctaat ggtcaatata                                                   20


<210> 18883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18883
cctaagctaa tggtcaatat                                                   20


<210> 18884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18884
gatgtaggcc cctaagctaa                                                   20


<210> 18885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18885
atgtcaagat gtaggcccct                                                   20


<210> 18886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18886
agaaattgat gtcaagatgt                                                   20


<210> 18887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18887
tagaaattga tgtcaagatg                                                   20


<210> 18888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18888
ggtatctaga aattgatgtc                                                   20


<210> 18889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18889
gacagatttc tctaggtatc                                                   20


<210> 18890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18890
ttagaaggac agatttctct                                                   20


<210> 18891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18891
tttagaagga cagatttctc                                                   20


<210> 18892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18892
aaatcacatt tttagaagga                                                   20


<210> 18893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18893
aattaaatca catttttaga                                                   20


<210> 18894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18894
gaattaaatc acatttttag                                                   20


<210> 18895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18895
tcagaattaa atcacatttt                                                   20


<210> 18896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18896
acttgaaaat cttacaaggt                                                   20


<210> 18897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18897
cataacttga aaatcttaca                                                   20


<210> 18898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18898
ccataacttg aaaatcttac                                                   20


<210> 18899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18899
aagggtagag taggcctggt                                                   20


<210> 18900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18900
gaagggtaga gtaggcctgg                                                   20


<210> 18901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18901
ggagaagggt agagtaggcc                                                   20


<210> 18902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18902
agggaggaga agggtagagt                                                   20


<210> 18903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18903
cagggaggag aagggtagag                                                   20


<210> 18904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18904
tcccagggag gagaagggta                                                   20


<210> 18905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 18905
catcccaggg aggagaaggg                                                   20


<210> 18906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18906
caccatccca gggaggagaa                                                   20


<210> 18907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18907
tcaccatccc agggaggaga                                                   20


<210> 18908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18908
gtcaccatcc cagggaggag                                                   20


<210> 18909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18909
actgtcacca tcccagggag                                                   20


<210> 18910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18910
gtactgtcac catcccaggg                                                   20


<210> 18911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18911
ggtactgtca ccatcccagg                                                   20


<210> 18912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18912
atggtactgt caccatccca                                                   20


<210> 18913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18913
gatggtactg tcaccatccc                                                   20


<210> 18914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18914
tgatggtact gtcaccatcc                                                   20


<210> 18915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18915
atggcatctg cctaagctga                                                   20


<210> 18916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18916
ctggttgatg gcatctgcct                                                   20


<210> 18917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18917
tgccatgaaa cgctggttga                                                   20


<210> 18918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18918
acagctgtgc catgaaacgc                                                   20


<210> 18919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18919
ataaagcatg tcctgagaca                                                   20


<210> 18920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18920
gaccaaataa agcatgtcct                                                   20


<210> 18921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18921
aacactctaa agaccaaata                                                   20


<210> 18922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18922
cagtttttaa aaacactcta                                                   20


<210> 18923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18923
tttaatattg gctactaatc                                                   20


<210> 18924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18924
tgtgcaaatg tctttaatat                                                   20


<210> 18925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18925
ttccaaaaaa gtcagaaatc                                                   20


<210> 18926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18926
tactaatttt ccaaaaaagt                                                   20


<210> 18927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18927
gagttactaa ttttccaaaa                                                   20


<210> 18928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18928
tggcctgtcc attattgtca                                                   20


<210> 18929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 18929
tatggcctgt ccattattgt                                                   20


<210> 18930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 18930
agggagggaa ggacgagcta                                                   20


<210> 18931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18931
ggagggaggg agggaaggac                                                   20


<210> 18932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18932
gagagggagg gagggaggga                                                   20


<210> 18933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18933
agagagggag ggagggaggg                                                   20


<210> 18934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18934
gagagagagg gagggaggga                                                   20


<210> 18935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18935
agagagagag ggagggaggg                                                   20


<210> 18936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18936
gagagagaga gggagggagg                                                   20


<210> 18937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18937
gggagagaga gagggaggga                                                   20


<210> 18938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18938
agggagagag agagggaggg                                                   20


<210> 18939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18939
gagggagaga gagagggagg                                                   20


<210> 18940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18940
gggagggaga gagagaggga                                                   20


<210> 18941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18941
agggagggag agagagaggg                                                   20


<210> 18942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18942
gagggaggga gagagagagg                                                   20


<210> 18943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18943
gggagggagg gagagagaga                                                   20


<210> 18944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18944
agggagggag ggagagagag                                                   20


<210> 18945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18945
gagggaggga gggagagaga                                                   20


<210> 18946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18946
gggagggagg gagggagaga                                                   20


<210> 18947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18947
gagggaggga gggagggaga                                                   20


<210> 18948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18948
gagagggagg gagggaggga                                                   20


<210> 18949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18949
gagagaggga gggagggagg                                                   20


<210> 18950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18950
gagagagagg gagggaggga                                                   20


<210> 18951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18951
agagagagag ggagggaggg                                                   20


<210> 18952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18952
gagagagaga gggagggagg                                                   20


<210> 18953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18953
gggagagaga gagggaggga                                                   20


<210> 18954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18954
agggagagag agagggaggg                                                   20


<210> 18955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18955
gagggagaga gagagggagg                                                   20


<210> 18956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18956
gggagggaga gagagaggga                                                   20


<210> 18957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18957
agggagggag agagagaggg                                                   20


<210> 18958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18958
gagggaggga gagagagagg                                                   20


<210> 18959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18959
gggagggagg gagagagaga                                                   20


<210> 18960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18960
agggagggag ggagagagag                                                   20


<210> 18961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18961
gagggaggga gggagagaga                                                   20


<210> 18962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18962
gggagggagg gagggagaga                                                   20


<210> 18963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18963
aagggaggga gggagggaga                                                   20


<210> 18964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18964
ggaagggagg gagggaggga                                                   20


<210> 18965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18965
gaggaaggga gggagggagg                                                   20


<210> 18966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18966
aagaggaagg gagggaggga                                                   20


<210> 18967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18967
aaagaggaag ggagggaggg                                                   20


<210> 18968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18968
gaaagaggaa gggagggagg                                                   20


<210> 18969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18969
aagaaagagg aagggaggga                                                   20


<210> 18970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18970
aaagaaagag gaagggaggg                                                   20


<210> 18971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18971
gaaagaaaga ggaagggagg                                                   20


<210> 18972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18972
aagaaagaaa gaggaaggga                                                   20


<210> 18973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18973
aaagaaagaa agaggaaggg                                                   20


<210> 18974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18974
gaaagaaaga aagaggaagg                                                   20


<210> 18975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 18975
aagaaagaaa gaaagaggaa                                                   20


<210> 18976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18976
aaagaaagaa agaaagagga                                                   20


<210> 18977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18977
gaaagaaaga aagaaagagg                                                   20


<210> 18978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 18978
aaagaaagaa agaaagaaag                                                   20


<210> 18979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18979
gaaagaaaga aagaaagaaa                                                   20


<210> 18980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18980
aagaaagaaa gaaagaaaga                                                   20


<210> 18981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18981
aagaaagaaa gaaagaaaga                                                   20


<210> 18982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18982
aagaaagaaa gaaagaaaga                                                   20


<210> 18983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18983
gagaaagaaa gaaagaaaga                                                   20


<210> 18984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18984
gaaagagaaa gaaagaaaga                                                   20


<210> 18985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18985
agaagaaaga gaaagaaaga                                                   20


<210> 18986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18986
agaaagaaga aagagaaaga                                                   20


<210> 18987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18987
agaaagaaag aagaaagaga                                                   20


<210> 18988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18988
agaaagaaag aaagaagaaa                                                   20


<210> 18989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18989
agagaaagaa agaaagaaga                                                   20


<210> 18990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18990
aaaaagagaa agaaagaaag                                                   20


<210> 18991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18991
aagaaaaaga gaaagaaaga                                                   20


<210> 18992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18992
gagaaagaaa aagagaaaga                                                   20


<210> 18993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18993
gagagagaaa gaaaaagaga                                                   20


<210> 18994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18994
gagggagaga gaaagaaaaa                                                   20


<210> 18995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18995
aagagggaga gagaaagaaa                                                   20


<210> 18996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 18996
gagagcaaga gggagagaga                                                   20


<210> 18997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18997
gagagagagc aagagggaga                                                   20


<210> 18998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18998
aagagagaga gcaagaggga                                                   20


<210> 18999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 18999
gaaagagaga gagcaagagg                                                   20


<210> 19000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19000
aagaaagaga gagagcaaga                                                   20


<210> 19001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19001
aaagaaagag agagagcaag                                                   20


<210> 19002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19002
gaaagaaaga gagagagcaa                                                   20


<210> 19003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19003
atgaaagaaa gagagagagc                                                   20


<210> 19004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19004
acagatgaaa gaaagagaga                                                   20


<210> 19005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19005
agacagatga aagaaagaga                                                   20


<210> 19006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19006
aaagacagat gaaagaaaga                                                   20


<210> 19007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19007
agaaagacag atgaaagaaa                                                   20


<210> 19008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19008
agagaaagac agatgaaaga                                                   20


<210> 19009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19009
agcgagagaa agacagatga                                                   20


<210> 19010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19010
tagaaaaagc gagagaaaga                                                   20


<210> 19011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19011
aagatagaaa aagcgagaga                                                   20


<210> 19012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19012
aataaagata gaaaaagcga                                                   20


<210> 19013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19013
ggaataaaga tagaaaaagc                                                   20


<210> 19014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19014
gagaggaata aagatagaaa                                                   20


<210> 19015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19015
cagagagaga ggaataaaga                                                   20


<210> 19016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19016
gacacagaga gagaggaata                                                   20


<210> 19017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19017
gaaaggagac acagagagag                                                   20


<210> 19018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19018
agaaaggaga cacagagaga                                                   20


<210> 19019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19019
aaagaaagga gacacagaga                                                   20


<210> 19020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19020
aaaaagaaag gagacacaga                                                   20


<210> 19021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19021
caaaaaagaa aggagacaca                                                   20


<210> 19022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19022
ctcaaaaaag aaaggagaca                                                   20


<210> 19023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19023
acctgtctca aaaaagaaag                                                   20


<210> 19024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19024
gaacctgtct caaaaaagaa                                                   20


<210> 19025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19025
agaacctgtc tcaaaaaaga                                                   20


<210> 19026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19026
agtaagaacc tgtctcaaaa                                                   20


<210> 19027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19027
tccagcctgg gagacagagt                                                   20


<210> 19028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19028
gcactccagc ctgggagaca                                                   20


<210> 19029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19029
ctgcactcca gcctgggaga                                                   20


<210> 19030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19030
gccactgcac tccagcctgg                                                   20


<210> 19031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19031
gtgccactgc actccagcct                                                   20


<210> 19032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19032
cgtgccactg cactccagcc                                                   20


<210> 19033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19033
atgatcgtgc cactgcactc                                                   20


<210> 19034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19034
gaccagggag gtggaggctg                                                   20


<210> 19035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19035
acctgagacc agggaggtgg                                                   20


<210> 19036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19036
cacctgagac cagggaggtg                                                   20


<210> 19037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19037
atcacctgag accagggagg                                                   20


<210> 19038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19038
aggatcacct gagaccaggg                                                   20


<210> 19039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19039
gaggatcacc tgagaccagg                                                   20


<210> 19040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19040
gggaggatca cctgagacca                                                   20


<210> 19041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19041
tgggaggatc acctgagacc                                                   20


<210> 19042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19042
gtgggaggat cacctgagac                                                   20


<210> 19043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19043
ctgaggtggg aggatcacct                                                   20


<210> 19044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19044
actcagaaga ctgaggtggg                                                   20


<210> 19045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19045
tactcagaag actgaggtgg                                                   20


<210> 19046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19046
gctactcaga agactgaggt                                                   20


<210> 19047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19047
agctactcag aagactgagg                                                   20


<210> 19048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19048
cctagctact cagaagactg                                                   20


<210> 19049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19049
tcctagctac tcagaagact                                                   20


<210> 19050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19050
ctgttatcct agctactcag                                                   20


<210> 19051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19051
catctgttat cctagctact                                                   20


<210> 19052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19052
gtggtgcaca tctgttatcc                                                   20


<210> 19053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19053
aaaaaattag ccaggcatgg                                                   20


<210> 19054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19054
atgaaaaaat tagccaggca                                                   20


<210> 19055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19055
aaaaaatgaa aaaattagcc                                                   20


<210> 19056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19056
caaaaaatga aaaaattagc                                                   20


<210> 19057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19057
tctacaaaaa atgaaaaaat                                                   20


<210> 19058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19058
ccaggagttc aagggcaaca                                                   20


<210> 19059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19059
gcttgagccc aggagttcaa                                                   20


<210> 19060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19060
cgcttgagcc caggagttca                                                   20


<210> 19061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19061
tcgcttgagc ccaggagttc                                                   20


<210> 19062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19062
ggcagatcgc ttgagcccag                                                   20


<210> 19063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19063
caggcagatc gcttgagccc                                                   20


<210> 19064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19064
gcaggcagat cgcttgagcc                                                   20


<210> 19065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19065
ccgaggcagg cagatcgctt                                                   20


<210> 19066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19066
ctttgggagg ccgaggcagg                                                   20


<210> 19067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19067
gtactttggg aggccgaggc                                                   20


<210> 19068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19068
agtactttgg gaggccgagg                                                   20


<210> 19069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19069
cctagtactt tgggaggccg                                                   20


<210> 19070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19070
tcctagtact ttgggaggcc                                                   20


<210> 19071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19071
tgtaatccta gtactttggg                                                   20


<210> 19072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19072
ctgtaatcct agtactttgg                                                   20


<210> 19073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19073
acctgtaatc ctagtacttt                                                   20


<210> 19074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19074
cacctgtaat cctagtactt                                                   20


<210> 19075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19075
gtggctcaca cctgtaatcc                                                   20


<210> 19076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19076
ccatctcagg ccaggtgcag                                                   20


<210> 19077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19077
tgaccatctc aggccaggtg                                                   20


<210> 19078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19078
caatgtgacc atctcaggcc                                                   20


<210> 19079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19079
tcaatgtgac catctcaggc                                                   20


<210> 19080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19080
gaaatcaatg tgaccatctc                                                   20


<210> 19081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19081
agaaatcaat gtgaccatct                                                   20


<210> 19082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19082
tcctgggagg gatgtttaca                                                   20


<210> 19083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19083
gcagtgcaca actcctggga                                                   20


<210> 19084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19084
agcagtgcac aactcctggg                                                   20


<210> 19085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19085
aagcagtgca caactcctgg                                                   20


<210> 19086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19086
caaagcagtg cacaactcct                                                   20


<210> 19087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19087
ccaaagcagt gcacaactcc                                                   20


<210> 19088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19088
tcacctaggc agacccaaag                                                   20


<210> 19089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19089
atttcaccta ggcagaccca                                                   20


<210> 19090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19090
atgactccat ttcacctagg                                                   20


<210> 19091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19091
aagatgactc catttcacct                                                   20


<210> 19092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19092
aaagatgact ccatttcacc                                                   20


<210> 19093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19093
ttgcctcagg tagacaggca                                                   20


<210> 19094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19094
gatatttgcc tcaggtagac                                                   20


<210> 19095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19095
ggatatttgc ctcaggtaga                                                   20


<210> 19096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19096
cactggatat ttgcctcagg                                                   20


<210> 19097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19097
gggcactgga tatttgcctc                                                   20


<210> 19098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19098
tgggcactgg atatttgcct                                                   20


<210> 19099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19099
catggaagag atgtgggcac                                                   20


<210> 19100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19100
gccagccatg gaagagatgt                                                   20


<210> 19101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19101
agccagccat ggaagagatg                                                   20


<210> 19102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19102
acatagagcc agccatggaa                                                   20


<210> 19103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19103
tgacatagag ccagccatgg                                                   20


<210> 19104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19104
cagtgacata gagccagcca                                                   20


<210> 19105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19105
catgtgcagt gacatagagc                                                   20


<210> 19106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19106
tgcccatgtg cagtgacata                                                   20


<210> 19107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19107
aatgcccatg tgcagtgaca                                                   20


<210> 19108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19108
caaactcaaa tgcccatgtg                                                   20


<210> 19109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19109
tggcgtacct ggattagggg                                                   20


<210> 19110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19110
acttggcgta cctggattag                                                   20


<210> 19111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19111
aacttggcgt acctggatta                                                   20


<210> 19112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19112
gaacttggcg tacctggatt                                                   20


<210> 19113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19113
tgaacttggc gtacctggat                                                   20


<210> 19114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19114
gcccctgaac ttggcgtacc                                                   20


<210> 19115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19115
cagtgctgag cccctgaact                                                   20


<210> 19116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19116
ggggccagtg agacagtgct                                                   20


<210> 19117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19117
tatcacaggg gccagtgaga                                                   20


<210> 19118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19118
accctatcac aggggccagt                                                   20


<210> 19119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19119
tgggacccta tcacaggggc                                                   20


<210> 19120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19120
tgcttgggac cctatcacag                                                   20


<210> 19121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19121
ctgcttggga ccctatcaca                                                   20


<210> 19122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19122
tctgcttggg accctatcac                                                   20


<210> 19123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19123
atctgcttgg gaccctatca                                                   20


<210> 19124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19124
actctaggac agatctgctt                                                   20


<210> 19125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19125
gactctagga cagatctgct                                                   20


<210> 19126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19126
gaggcaacga gactctagga                                                   20


<210> 19127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19127
tcaggaggca acgagactct                                                   20


<210> 19128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19128
ttcaggaggc aacgagactc                                                   20


<210> 19129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19129
tgcatggttc aggaggcaac                                                   20


<210> 19130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19130
aagggggtgc atggttcagg                                                   20


<210> 19131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19131
gaagggggtg catggttcag                                                   20


<210> 19132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19132
ttgaaggggg tgcatggttc                                                   20


<210> 19133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19133
gttgaagggg gtgcatggtt                                                   20


<210> 19134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19134
cagaggttga agggggtgca                                                   20


<210> 19135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19135
tggcatccag aggttgaagg                                                   20


<210> 19136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19136
ttggcatcca gaggttgaag                                                   20


<210> 19137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19137
gttggcatcc agaggttgaa                                                   20


<210> 19138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19138
tgttggcatc cagaggttga                                                   20


<210> 19139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19139
gtgttggcat ccagaggttg                                                   20


<210> 19140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19140
tgacaagtgt tggcatccag                                                   20


<210> 19141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19141
ctgacaagtg ttggcatcca                                                   20


<210> 19142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19142
tcctgacaag tgttggcatc                                                   20


<210> 19143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19143
cccaaggtcc tgacaagtgt                                                   20


<210> 19144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19144
aatcttccca aggtcctgac                                                   20


<210> 19145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19145
agtatccaac aatcttccca                                                   20


<210> 19146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19146
gagtatccaa caatcttccc                                                   20


<210> 19147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19147
agaggtgaca aaacaaaggg                                                   20


<210> 19148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19148
agagaggtga caaaacaaag                                                   20


<210> 19149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19149
aagagaggtg acaaaacaaa                                                   20


<210> 19150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19150
gaagagaggt gacaaaacaa                                                   20


<210> 19151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19151
tgaagagagg tgacaaaaca                                                   20


<210> 19152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19152
ctgcatctag acttgaagag                                                   20


<210> 19153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19153
cctgcatcta gacttgaaga                                                   20


<210> 19154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19154
gccctgcatc tagacttgaa                                                   20


<210> 19155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19155
gagccctgca tctagacttg                                                   20


<210> 19156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19156
ttaactggga gccctgcatc                                                   20


<210> 19157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19157
aatctctcag tattaactgg                                                   20


<210> 19158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19158
ggaatctctc agtattaact                                                   20


<210> 19159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19159
aggaatctct cagtattaac                                                   20


<210> 19160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19160
gcctgctctc aggaatctct                                                   20


<210> 19161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19161
agcgcaggcc gcctgctctc                                                   20


<210> 19162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19162
tagcgcaggc cgcctgctct                                                   20


<210> 19163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19163
atgtcacggc ttgttagcgc                                                   20


<210> 19164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19164
aatgtcacgg cttgttagcg                                                   20


<210> 19165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19165
gaagaaatgt cacggcttgt                                                   20


<210> 19166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 19166
agaggcctga agaaatgtca                                                   20


<210> 19167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19167
gggaatagga aagaggcctg                                                   20


<210> 19168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19168
gactcttggg aataggaaag                                                   20


<210> 19169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19169
tgactcttgg gaataggaaa                                                   20


<210> 19170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19170
actgactctt gggaatagga                                                   20


<210> 19171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19171
tctcactgac tcttgggaat                                                   20


<210> 19172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19172
atctcactga ctcttgggaa                                                   20


<210> 19173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19173
ttggcatctc actgactctt                                                   20


<210> 19174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19174
cttggcatct cactgactct                                                   20


<210> 19175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19175
caggccatct ggaggaagct                                                   20


<210> 19176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19176
gtctccaggc catctggagg                                                   20


<210> 19177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19177
taggtctcca ggccatctgg                                                   20


<210> 19178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19178
ctaggtctcc aggccatctg                                                   20


<210> 19179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19179
cactaggtct ccaggccatc                                                   20


<210> 19180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19180
tgtcgggtca ctaggtctcc                                                   20


<210> 19181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19181
gtgtcgggtc actaggtctc                                                   20


<210> 19182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19182
cccaggagtg tcgggtcact                                                   20


<210> 19183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19183
tcccaggagt gtcgggtcac                                                   20


<210> 19184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19184
gtcagattcc caggagtgtc                                                   20


<210> 19185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 19185
tgtcagattc ccaggagtgt                                                   20


<210> 19186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19186
caaacctgtc agattcccag                                                   20


<210> 19187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19187
gccaaacctg tcagattccc                                                   20


<210> 19188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19188
agccaaacct gtcagattcc                                                   20


<210> 19189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19189
ggtttgtcag ccaaacctgt                                                   20


<210> 19190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19190
tatcagagcc acaggtttgt                                                   20


<210> 19191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19191
cccactttta tcagagccac                                                   20


<210> 19192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19192
acccactttt atcagagcca                                                   20


<210> 19193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19193
caggccaccc acttttatca                                                   20


<210> 19194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19194
cacaggccac ccacttttat                                                   20


<210> 19195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19195
ctctacagga gaagtgccac                                                   20


<210> 19196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19196
cctctacagg agaagtgcca                                                   20


<210> 19197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19197
caggacgccc tctacaggag                                                   20


<210> 19198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19198
ctccaggacg ccctctacag                                                   20


<210> 19199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19199
agctccagga cgccctctac                                                   20


<210> 19200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19200
cagctccagg acgccctcta                                                   20


<210> 19201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19201
tcttctctaa actcagctcc                                                   20


<210> 19202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19202
ctcttctcta aactcagctc                                                   20


<210> 19203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19203
tgatggctct tctctaaact                                                   20


<210> 19204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19204
gtctcactca catgcaatga                                                   20


<210> 19205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19205
agcaccttca acctgcctat                                                   20


<210> 19206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19206
aatcacagcc ccaatgtctc                                                   20


<210> 19207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19207
ttcccttgtg cccgaaatca                                                   20


<210> 19208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19208
agctccttcc agcctcaagg                                                   20


<210> 19209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19209
cccagctcct tccagcctca                                                   20


<210> 19210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19210
ccccagctcc ttccagcctc                                                   20


<210> 19211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19211
tccagagccc cagctccttc                                                   20


<210> 19212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19212
gttgtctgac tccagagccc                                                   20


<210> 19213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19213
atccaggttg tctgactcca                                                   20


<210> 19214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19214
aaatccaggt tgtctgactc                                                   20


<210> 19215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19215
cagacctgga tctcaaatcc                                                   20


<210> 19216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19216
acagacctgg atctcaaatc                                                   20


<210> 19217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19217
aagcgaataa gccacagacc                                                   20


<210> 19218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19218
ccaagcaagc gaataagcca                                                   20


<210> 19219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19219
catctgccaa gcaagcgaat                                                   20


<210> 19220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19220
aagtctccca tctgccaagc                                                   20


<210> 19221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19221
ccgaaagtct cccatctgcc                                                   20


<210> 19222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19222
atggttccat gatgacccga                                                   20


<210> 19223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19223
gggtgggtga ggaaaaagaa                                                   20


<210> 19224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19224
ctcaggggtg ggtgaggaaa                                                   20


<210> 19225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19225
aagatcctca ggggtgggtg                                                   20


<210> 19226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19226
taagatcctc aggggtgggt                                                   20


<210> 19227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19227
tttttaagat cctcaggggt                                                   20


<210> 19228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19228
gtttttaaga tcctcagggg                                                   20


<210> 19229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19229
gtcgttttta agatcctcag                                                   20


<210> 19230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19230
agtcgttttt aagatcctca                                                   20


<210> 19231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19231
tagtcgtttt taagatcctc                                                   20


<210> 19232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19232
atagtcgttt ttaagatcct                                                   20


<210> 19233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19233
cctgagagat agtcgttttt                                                   20


<210> 19234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19234
ctcacaacaa ccctgagaga                                                   20


<210> 19235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19235
tatgctcaca acaaccctga                                                   20


<210> 19236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19236
tttatgctca caacaaccct                                                   20


<210> 19237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19237
caatgtgtca ggcatagcac                                                   20


<210> 19238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19238
cacttacaat gtgtcaggca                                                   20


<210> 19239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19239
ctgagcactt acaatgtgtc                                                   20


<210> 19240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19240
actgagcact tacaatgtgt                                                   20


<210> 19241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19241
cacagcagct aatacttact                                                   20


<210> 19242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19242
aataacagca ataatcacag                                                   20


<210> 19243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19243
aacaataaca gcaataatca                                                   20


<210> 19244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19244
ctcttatcaa ataacaataa                                                   20


<210> 19245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19245
tgcaccaaga ggggacttcc                                                   20


<210> 19246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19246
tcccttatct gcaccaagag                                                   20


<210> 19247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19247
ctcccttatc tgcaccaaga                                                   20


<210> 19248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19248
gctcccttat ctgcaccaag                                                   20


<210> 19249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19249
ggctccctta tctgcaccaa                                                   20


<210> 19250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19250
ttggctccct tatctgcacc                                                   20


<210> 19251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19251
gccttctcct ttctgggcct                                                   20


<210> 19252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19252
ggacatgcct tctcctttct                                                   20


<210> 19253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19253
gggacatgcc ttctcctttc                                                   20


<210> 19254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19254
cttttcgctg actcagagtg                                                   20


<210> 19255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19255
gcttttcgct gactcagagt                                                   20


<210> 19256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19256
agcttttcgc tgactcagag                                                   20


<210> 19257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19257
cccagctttt cgctgactca                                                   20


<210> 19258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19258
gccccagctt ttcgctgact                                                   20


<210> 19259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19259
gagacttggg tctgtggccc                                                   20


<210> 19260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19260
cgactggaga cttgggtctg                                                   20


<210> 19261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19261
tcctgggcga ctggagactt                                                   20


<210> 19262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19262
ctcctgggcg actggagact                                                   20


<210> 19263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19263
gtctgactcc tgggcgactg                                                   20


<210> 19264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19264
gggtctgact cctgggcgac                                                   20


<210> 19265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19265
gggagcaggg tctgactcct                                                   20


<210> 19266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19266
agggagcagg gtctgactcc                                                   20


<210> 19267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19267
tgtccttgtg ggagggagca                                                   20


<210> 19268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19268
ctgtccttgt gggagggagc                                                   20


<210> 19269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19269
cctgtccttg tgggagggag                                                   20


<210> 19270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19270
tctcctgtcc ttgtgggagg                                                   20


<210> 19271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19271
cctctcctgt ccttgtggga                                                   20


<210> 19272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19272
tcctctcctg tccttgtggg                                                   20


<210> 19273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19273
ttcctctcct gtccttgtgg                                                   20


<210> 19274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19274
ccttcctctc ctgtccttgt                                                   20


<210> 19275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19275
cccttcctct cctgtccttg                                                   20


<210> 19276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19276
gctctgggga ctgcaccagc                                                   20


<210> 19277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19277
ctgtgctctg gggactgcac                                                   20


<210> 19278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19278
agggaagaca ctgtgctctg                                                   20


<210> 19279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19279
cagggaagac actgtgctct                                                   20


<210> 19280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19280
tcagggaaga cactgtgctc                                                   20


<210> 19281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19281
actcccaccc agattcaggg                                                   20


<210> 19282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19282
gaaactccca cccagattca                                                   20


<210> 19283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19283
ggaaactccc acccagattc                                                   20


<210> 19284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19284
gggaaactcc cacccagatt                                                   20


<210> 19285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19285
ggcttgggga aactcccacc                                                   20


<210> 19286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19286
gtttttctct tgatggcttg                                                   20


<210> 19287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19287
tgtttttctc ttgatggctt                                                   20


<210> 19288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19288
atgtttttct cttgatggct                                                   20


<210> 19289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19289
tggtaatgtt tttctcttga                                                   20


<210> 19290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19290
tgtgctgcgg agcttccgct                                                   20


<210> 19291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19291
ggaagcctgt ctgtgctgcg                                                   20


<210> 19292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 19292
agggaagcct gtctgtgctg                                                   20


<210> 19293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19293
ctgggcgtgg ccaagaaggg                                                   20


<210> 19294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19294
gagctgggcg tggccaagaa                                                   20


<210> 19295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19295
agagctgggc gtggccaaga                                                   20


<210> 19296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19296
tagagctggg cgtggccaag                                                   20


<210> 19297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19297
tgctagagct gggcgtggcc                                                   20


<210> 19298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19298
gagtctgcta gagctgggcg                                                   20


<210> 19299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19299
actgtgagtc tgctagagct                                                   20


<210> 19300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19300
cactgtgagt ctgctagagc                                                   20


<210> 19301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19301
tcgtcactgt gagtctgcta                                                   20


<210> 19302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19302
catcgtcact gtgagtctgc                                                   20


<210> 19303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19303
gactgcatca tcgtcactgt                                                   20


<210> 19304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19304
actattattt ccagaagaag                                                   20


<210> 19305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19305
catactatta tttccagaag                                                   20


<210> 19306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19306
acccatacta ttatttccag                                                   20


<210> 19307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19307
tcgacccata ctattatttc                                                   20


<210> 19308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19308
catatttttt actgctgaaa                                                   20


<210> 19309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19309
gaaagcttgt ttccactcct                                                   20


<210> 19310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19310
tgaaagcttg tttccactcc                                                   20


<210> 19311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19311
cacagatccc actgtgatga                                                   20


<210> 19312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19312
tatcattgcc tccgacccca                                                   20


<210> 19313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19313
ggattttcta ttttgtaaat                                                   20


<210> 19314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19314
tagcaactga acaaaacaaa                                                   20


<210> 19315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19315
atagcaactg aacaaaacaa                                                   20


<210> 19316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19316
tcaggagccc acagataaca                                                   20


<210> 19317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19317
ggccaatcct caggagccca                                                   20


<210> 19318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19318
ttaccctggc caatcctcag                                                   20


<210> 19319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19319
tgttaccctg gccaatcctc                                                   20


<210> 19320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19320
ctgttaccct ggccaatcct                                                   20


<210> 19321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19321
tgtcacgttg actgttaccc                                                   20


<210> 19322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19322
cacagcccct gagaatggtg                                                   20


<210> 19323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19323
gcatgcacag cccctgagaa                                                   20


<210> 19324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19324
ctgcagcatg cacagcccct                                                   20


<210> 19325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19325
tggaaaaact gcagcatgca                                                   20


<210> 19326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19326
ccattcacgt ggaaaaactg                                                   20


<210> 19327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19327
cactcccacc accattcacg                                                   20


<210> 19328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19328
atattataat aatgatctta                                                   20


<210> 19329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19329
acacgtttta actactgaac                                                   20


<210> 19330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19330
ctgggctggg attttaatcc                                                   20


<210> 19331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19331
tctgggctgg gattttaatc                                                   20


<210> 19332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19332
agctaggaaa tgtctgggct                                                   20


<210> 19333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19333
aagctaggaa atgtctgggc                                                   20


<210> 19334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19334
acataagcta ggaaatgtct                                                   20


<210> 19335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19335
tacataagct aggaaatgtc                                                   20


<210> 19336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19336
tgtccaagct tacataagct                                                   20


<210> 19337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19337
ttgtccaagc ttacataagc                                                   20


<210> 19338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19338
ttatttgtcc aagcttacat                                                   20


<210> 19339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19339
gaaggatgca ttatttgtcc                                                   20


<210> 19340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19340
gaggaaattg aggtacagga                                                   20


<210> 19341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19341
tgaggaaatt gaggtacagg                                                   20


<210> 19342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19342
agatgaggaa attgaggtac                                                   20


<210> 19343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19343
cagatgagga aattgaggta                                                   20


<210> 19344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19344
ttatacagat gaggaaattg                                                   20


<210> 19345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19345
attatacaga tgaggaaatt                                                   20


<210> 19346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19346
ttatgcccat tatacagatg                                                   20


<210> 19347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19347
tttatgccca ttatacagat                                                   20


<210> 19348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19348
ctcattttat gcccattata                                                   20


<210> 19349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19349
gttaagaact gcacatgcat                                                   20


<210> 19350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19350
tgtctgccag gccctttgtt                                                   20


<210> 19351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19351
tgaatgaatt actgtctgcc                                                   20


<210> 19352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19352
atgaatgaat tactgtctgc                                                   20


<210> 19353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19353
caatgaatca ttgttcttac                                                   20


<210> 19354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19354
agagcctaaa agaatcttag                                                   20


<210> 19355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19355
cagagcctaa aagaatctta                                                   20


<210> 19356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19356
cacagagcct aaaagaatct                                                   20


<210> 19357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19357
tagagacaca cagagcctaa                                                   20


<210> 19358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19358
aagacaatta gagacacaca                                                   20


<210> 19359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19359
ttaagacaat tagagacaca                                                   20


<210> 19360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19360
tgtcctattt aagacaatta                                                   20


<210> 19361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19361
tctgtcctat ttaagacaat                                                   20


<210> 19362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19362
gtcagaattc tgtcctattt                                                   20


<210> 19363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19363
gttctgacct ctctcagtgt                                                   20


<210> 19364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19364
agcctggttc tgacctctct                                                   20


<210> 19365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19365
gttgttgtgt tacccgagcc                                                   20


<210> 19366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19366
tgctggttgt tgtgttaccc                                                   20


<210> 19367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19367
tctctgtctc ccttccctgc                                                   20


<210> 19368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19368
gaaggaaaag cacctgaccc                                                   20


<210> 19369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19369
gataaaaaga tatgaaggaa                                                   20


<210> 19370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19370
gctcagataa aaagatatga                                                   20


<210> 19371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19371
ggctcagata aaaagatatg                                                   20


<210> 19372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19372
tggtgagggg ctcagataaa                                                   20


<210> 19373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19373
tctcaggctg gtgaggggct                                                   20


<210> 19374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19374
ctgtttctca ggctggtgag                                                   20


<210> 19375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19375
tctgtttctc aggctggtga                                                   20


<210> 19376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19376
gtctgtttct caggctggtg                                                   20


<210> 19377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19377
tgtctgtttc tcaggctggt                                                   20


<210> 19378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19378
gcattgtctg tttctcaggc                                                   20


<210> 19379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19379
ggatgcattg tctgtttctc                                                   20


<210> 19380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19380
aggatgcatt gtctgtttct                                                   20


<210> 19381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19381
ctgttttctt ctccataaga                                                   20


<210> 19382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19382
cctgttttct tctccataag                                                   20


<210> 19383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19383
cagcctgttt tcttctccat                                                   20


<210> 19384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19384
gagaaagtca cttaaactct                                                   20


<210> 19385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19385
atcagtcttg tggcatgaga                                                   20


<210> 19386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19386
ttgaatcagt cttgtggcat                                                   20


<210> 19387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19387
tactctttga atcagtcttg                                                   20


<210> 19388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19388
tccatagata ctctttgaat                                                   20


<210> 19389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19389
tgcctacaag ggacactcca                                                   20


<210> 19390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19390
ccacactgac ttgcctacaa                                                   20


<210> 19391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19391
accacactga cttgcctaca                                                   20


<210> 19392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19392
caccacactg acttgcctac                                                   20


<210> 19393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19393
cccaggtctc tggaagacac                                                   20


<210> 19394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19394
gggtggaccc aggtctctgg                                                   20


<210> 19395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19395
ccagggtgga cccaggtctc                                                   20


<210> 19396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19396
ggtggatcca gggtggaccc                                                   20


<210> 19397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19397
gggtggatcc agggtggacc                                                   20


<210> 19398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19398
tggtgagggt ggatccaggg                                                   20


<210> 19399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19399
agctggtgag ggtggatcca                                                   20


<210> 19400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19400
tagctggtga gggtggatcc                                                   20


<210> 19401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19401
atagctggtg agggtggatc                                                   20


<210> 19402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19402
aattgtatag ctggtgaggg                                                   20


<210> 19403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19403
caaaattgta tagctggtga                                                   20


<210> 19404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19404
ccaaaattgt atagctggtg                                                   20


<210> 19405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19405
cccaaaattg tatagctggt                                                   20


<210> 19406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19406
cctgcccaaa attgtatagc                                                   20


<210> 19407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19407
atatcctgcc caaaattgta                                                   20


<210> 19408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19408
gagagcacta agactcagag                                                   20


<210> 19409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19409
agagagcact aagactcaga                                                   20


<210> 19410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19410
aaagagagca ctaagactca                                                   20


<210> 19411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19411
caaaagagag cactaagact                                                   20


<210> 19412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19412
acatgacaaa agagagcact                                                   20


<210> 19413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19413
caccctcaca tgacaaaaga                                                   20


<210> 19414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19414
atcaccctca catgacaaaa                                                   20


<210> 19415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19415
acatcaccct cacatgacaa                                                   20


<210> 19416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19416
agtgtcacaa caacattatg                                                   20


<210> 19417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19417
cagtgtcaca acaacattat                                                   20


<210> 19418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19418
gtgctttatg aatgttattt                                                   20


<210> 19419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19419
cttggtgcct gcaatgagtc                                                   20


<210> 19420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19420
gcttggtgcc tgcaatgagt                                                   20


<210> 19421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19421
atgtgcttgg tgcctgcaat                                                   20


<210> 19422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19422
aagcaagaaa gtcatgtgct                                                   20


<210> 19423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19423
gccacttttt taaagcaaga                                                   20


<210> 19424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19424
aagtgccact tttttaaagc                                                   20


<210> 19425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19425
aggaaagtgc cactttttta                                                   20


<210> 19426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19426
tttcccacag tgtcagagga                                                   20


<210> 19427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19427
ggcctttccc acagtgtcag                                                   20


<210> 19428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19428
aggcctttcc cacagtgtca                                                   20


<210> 19429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19429
aaaggccttt cccacagtgt                                                   20


<210> 19430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19430
gagagaaaag gcctttccca                                                   20


<210> 19431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19431
gtggaagcaa gagagagaaa                                                   20


<210> 19432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19432
agtggaagca agagagagaa                                                   20


<210> 19433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19433
agaaaagtgg aagcaagaga                                                   20


<210> 19434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19434
ttagaaaagt ggaagcaaga                                                   20


<210> 19435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19435
agttagaaaa gtggaagcaa                                                   20


<210> 19436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19436
acagttagaa aagtggaagc                                                   20


<210> 19437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19437
ttctacagtt agaaaagtgg                                                   20


<210> 19438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19438
tcattctaca gttagaaaag                                                   20


<210> 19439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19439
ccctcattct acagttagaa                                                   20


<210> 19440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19440
ccacaccctc attctacagt                                                   20


<210> 19441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19441
gagcccacac cctcattcta                                                   20


<210> 19442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19442
gccttatgga atagacattt                                                   20


<210> 19443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19443
ccacagaggg ccttatggaa                                                   20


<210> 19444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19444
taagaccaca gagggcctta                                                   20


<210> 19445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19445
agtcagccta agaccacaga                                                   20


<210> 19446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19446
aagtcagcct aagaccacag                                                   20


<210> 19447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19447
gaagtcagcc taagaccaca                                                   20


<210> 19448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19448
aagaagtcag cctaagacca                                                   20


<210> 19449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19449
tattcccaag aagtcagcct                                                   20


<210> 19450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19450
aatgcttatt cccaagaagt                                                   20


<210> 19451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19451
agagaatgct tattcccaag                                                   20


<210> 19452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19452
agaagagaat gcttattccc                                                   20


<210> 19453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19453
aaggaaaaat ggaaagagaa                                                   20


<210> 19454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19454
aaaaggaaaa atggaaagag                                                   20


<210> 19455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19455
atgaaaagga aaaatggaaa                                                   20


<210> 19456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19456
atatgaaaag gaaaaatgga                                                   20


<210> 19457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19457
gttgatatga aaaggaaaaa                                                   20


<210> 19458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19458
atcctaaagt tgatatgaaa                                                   20


<210> 19459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19459
catcctaaag ttgatatgaa                                                   20


<210> 19460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19460
taggctgagg tcacatccta                                                   20


<210> 19461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19461
ttttggcagc acctaggctg                                                   20


<210> 19462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19462
gttttggcag cacctaggct                                                   20


<210> 19463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19463
ctcatgtttt ggcagcacct                                                   20


<210> 19464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19464
cctcatgttt tggcagcacc                                                   20


<210> 19465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19465
cagcatgcct catgttttgg                                                   20


<210> 19466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19466
aatcagcatg cctcatgttt                                                   20


<210> 19467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19467
gttctggaac atggtggaat                                                   20


<210> 19468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19468
cagtaggttc tggaacatgg                                                   20


<210> 19469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19469
cagcagtagg ttctggaaca                                                   20


<210> 19470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19470
aaaggggcag cagtaggttc                                                   20


<210> 19471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19471
gctgtgaaag gggcagcagt                                                   20


<210> 19472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19472
ggctgtgaaa ggggcagcag                                                   20


<210> 19473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19473
cagggctgtg aaaggggcag                                                   20


<210> 19474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19474
atccagggct gtgaaagggg                                                   20


<210> 19475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19475
ataatccagg gctgtgaaag                                                   20


<210> 19476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19476
cataatccag ggctgtgaaa                                                   20


<210> 19477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19477
ccataatcca gggctgtgaa                                                   20


<210> 19478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19478
gccataatcc agggctgtga                                                   20


<210> 19479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19479
actccctccg ccataatcca                                                   20


<210> 19480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19480
cactccctcc gccataatcc                                                   20


<210> 19481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19481
ccactccctc cgccataatc                                                   20


<210> 19482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19482
gaaatgtgac tacttgtccc                                                   20


<210> 19483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19483
ggtggagggg gaaggcccag                                                   20


<210> 19484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19484
aggtggaggg ggaaggccca                                                   20


<210> 19485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19485
ttaggtggag ggggaaggcc                                                   20


<210> 19486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19486
cagacttagg tggaggggga                                                   20


<210> 19487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19487
gcagacttag gtggaggggg                                                   20


<210> 19488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19488
gctgcagact taggtggagg                                                   20


<210> 19489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19489
ggctgcagac ttaggtggag                                                   20


<210> 19490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19490
aggctgcaga cttaggtgga                                                   20


<210> 19491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19491
taggctgcag acttaggtgg                                                   20


<210> 19492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19492
ataggctgca gacttaggtg                                                   20


<210> 19493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19493
ttataggctg cagacttagg                                                   20


<210> 19494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19494
ttcttatagg ctgcagactt                                                   20


<210> 19495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19495
cttcttatag gctgcagact                                                   20


<210> 19496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19496
gtccagcttc ttataggctg                                                   20


<210> 19497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19497
tttggggtcc agcttcttat                                                   20


<210> 19498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19498
ctttggggtc cagcttctta                                                   20


<210> 19499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19499
aactgtctgg ctttggggtc                                                   20


<210> 19500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19500
accagaactg tctggctttg                                                   20


<210> 19501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19501
caccagaact gtctggcttt                                                   20


<210> 19502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19502
tcaccagaac tgtctggctt                                                   20


<210> 19503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19503
ctggattcac cagaactgtc                                                   20


<210> 19504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19504
aggtgaccta ctggattcac                                                   20


<210> 19505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19505
ccaagctgga ggtgacctac                                                   20


<210> 19506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19506
agcagggtcc accaagctgg                                                   20


<210> 19507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19507
cagcagggtc caccaagctg                                                   20


<210> 19508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19508
cgcagcaggg tccaccaagc                                                   20


<210> 19509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19509
tgtccgcagc agggtccacc                                                   20


<210> 19510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19510
ctgccttcat gtccgcagca                                                   20


<210> 19511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19511
cctgccttca tgtccgcagc                                                   20


<210> 19512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19512
tcctgccttc atgtccgcag                                                   20


<210> 19513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19513
gcatcctgcc ttcatgtccg                                                   20


<210> 19514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19514
aggcagaagc tagaaagggt                                                   20


<210> 19515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19515
tgataggcag aagctagaaa                                                   20


<210> 19516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19516
atgataggca gaagctagaa                                                   20


<210> 19517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19517
catgataggc agaagctaga                                                   20


<210> 19518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19518
cacacatgat aggcagaagc                                                   20


<210> 19519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19519
cacgcacaca tgataggcag                                                   20


<210> 19520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19520
acacacgcac acatgatagg                                                   20


<210> 19521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19521
caaacacacg cacacatgat                                                   20


<210> 19522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19522
tcaaacacac gcacacatga                                                   20


<210> 19523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19523
cctgaattaa gccacctcac                                                   20


<210> 19524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19524
cttttcttaa cccctgaatt                                                   20


<210> 19525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19525
acccagacag accggctgcc                                                   20


<210> 19526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 19526
gaatttgaac ccagacagac                                                   20


<210> 19527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19527
catcagaatt tgaacccaga                                                   20


<210> 19528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19528
gccacatcag aatttgaacc                                                   20


<210> 19529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19529
gttgagttta gtggccacat                                                   20


<210> 19530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19530
gatcatagag ttgagtttag                                                   20


<210> 19531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19531
caagatcata gagttgagtt                                                   20


<210> 19532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19532
cttcccaaga tcatagagtt                                                   20


<210> 19533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19533
ataatcttcc caagatcata                                                   20


<210> 19534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19534
aaataatctt cccaagatca                                                   20


<210> 19535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19535
aaaggttaaa taatcttccc                                                   20


<210> 19536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19536
tggaaaaatg gagatgcaaa                                                   20


<210> 19537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19537
atggaaaaat ggagatgcaa                                                   20


<210> 19538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19538
ctttcccaga tggaaaaatg                                                   20


<210> 19539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19539
ccctttccca gatggaaaaa                                                   20


<210> 19540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19540
ttgttattcc ctttcccaga                                                   20


<210> 19541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19541
actcttgtta ttccctttcc                                                   20


<210> 19542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19542
tcacaacaac cctacatggt                                                   20


<210> 19543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19543
ttcacaacaa ccctacatgg                                                   20


<210> 19544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19544
attttcacaa caaccctaca                                                   20


<210> 19545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19545
taatactcag atgcttctca                                                   20


<210> 19546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19546
acaggaatag taataatact                                                   20


<210> 19547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19547
ccttgcccca cccacaggaa                                                   20


<210> 19548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19548
tccaaccttg ccccacccac                                                   20


<210> 19549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19549
ctccaacctt gccccaccca                                                   20


<210> 19550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19550
gataaagtat ctgactcaga                                                   20


<210> 19551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19551
ggataaagta tctgactcag                                                   20


<210> 19552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19552
tggataaagt atctgactca                                                   20


<210> 19553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19553
actggataaa gtatctgact                                                   20


<210> 19554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19554
atttcactat atactggata                                                   20


<210> 19555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19555
tactggattt cactatatac                                                   20


<210> 19556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19556
taacaagata caatccatac                                                   20


<210> 19557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19557
tagtattatt tactcttaac                                                   20


<210> 19558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19558
aattttcctc catcacttgt                                                   20


<210> 19559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19559
cttttctttg gcatctagtt                                                   20


<210> 19560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19560
cggaactttt ctttggcatc                                                   20


<210> 19561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19561
aggaagtcgg aacttttctt                                                   20


<210> 19562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 19562
taacaaaagc atcaggaagt                                                   20


<210> 19563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19563
gttgtaacaa aagcatcagg                                                   20


<210> 19564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19564
gctgttgtaa caaaagcatc                                                   20


<210> 19565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19565
tgctgttgta acaaaagcat                                                   20


<210> 19566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19566
caaggttgct gttgtaacaa                                                   20


<210> 19567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19567
agggaggaaa catggaaaca                                                   20


<210> 19568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19568
aagggaggaa acatggaaac                                                   20


<210> 19569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19569
acagtggaag ggaggaaaca                                                   20


<210> 19570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19570
aggggaagac agtggaaggg                                                   20


<210> 19571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19571
aaggggaaga cagtggaagg                                                   20


<210> 19572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19572
ggaaggggaa gacagtggaa                                                   20


<210> 19573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19573
gggaagggga agacagtgga                                                   20


<210> 19574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19574
agggaagggg aagacagtgg                                                   20


<210> 19575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19575
gggagggaag gggaagacag                                                   20


<210> 19576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19576
ttggggaggg aaggggaaga                                                   20


<210> 19577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19577
agagttgggg agggaagggg                                                   20


<210> 19578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19578
aaaagagttg gggagggaag                                                   20


<210> 19579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19579
aaaaagagtt ggggagggaa                                                   20


<210> 19580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19580
gaaaaagagt tggggaggga                                                   20


<210> 19581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19581
agaaaaagag ttggggaggg                                                   20


<210> 19582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19582
aggagaaaaa gagttgggga                                                   20


<210> 19583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19583
aaggagaaaa agagttgggg                                                   20


<210> 19584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19584
taaggagaaa aagagttggg                                                   20


<210> 19585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19585
cttaaggaga aaaagagttg                                                   20


<210> 19586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19586
acttaaggag aaaaagagtt                                                   20


<210> 19587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19587
cacttaagga gaaaaagagt                                                   20


<210> 19588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19588
ttgtcactta aggagaaaaa                                                   20


<210> 19589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19589
tgttgtcact taaggagaaa                                                   20


<210> 19590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19590
tttcaatgtt gtcacttaag                                                   20


<210> 19591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19591
attttcaatg ttgtcactta                                                   20


<210> 19592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19592
gattttcaat gttgtcactt                                                   20


<210> 19593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19593
tttatgacca caattaacag                                                   20


<210> 19594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19594
acttttatga ccacaattaa                                                   20


<210> 19595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19595
ttttatctaa agacaatctt                                                   20


<210> 19596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19596
aaatgtcact tttttatcta                                                   20


<210> 19597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19597
gttgcctcta ccttgaaatg                                                   20


<210> 19598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19598
agttgcctct accttgaaat                                                   20


<210> 19599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19599
cacttgaatt ttctggatct                                                   20


<210> 19600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19600
ggacaaccac ttgaattttc                                                   20


<210> 19601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19601
agttgccctt tacaaaacat                                                   20


<210> 19602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19602
tagttgccct ttacaaaaca                                                   20


<210> 19603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19603
agcctggagc cagaggcagc                                                   20


<210> 19604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19604
ggagagcctg gagccagagg                                                   20


<210> 19605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19605
ccaggagagc ctggagccag                                                   20


<210> 19606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19606
accaggagag cctggagcca                                                   20


<210> 19607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19607
gaaccaggag agcctggagc                                                   20


<210> 19608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19608
aagtgaacca ggagagcctg                                                   20


<210> 19609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19609
gaaagtgaac caggagagcc                                                   20


<210> 19610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19610
cacaggaaag tgaaccagga                                                   20


<210> 19611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19611
agcacaggaa agtgaaccag                                                   20


<210> 19612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19612
caagcacagg aaagtgaacc                                                   20


<210> 19613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19613
acaagcacag gaaagtgaac                                                   20


<210> 19614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19614
tgggatgaac aagcacagga                                                   20


<210> 19615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19615
gctttgggat gaacaagcac                                                   20


<210> 19616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19616
ggctttggga tgaacaagca                                                   20


<210> 19617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19617
ggaatggctt tgggatgaac                                                   20


<210> 19618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19618
gagctggtgg gaatggcttt                                                   20


<210> 19619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19619
tgagctggtg ggaatggctt                                                   20


<210> 19620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19620
ccaggctgag ctggtgggaa                                                   20


<210> 19621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19621
aggacccagg ctgagctggt                                                   20


<210> 19622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19622
gaggacccag gctgagctgg                                                   20


<210> 19623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19623
tgggaggacc caggctgagc                                                   20


<210> 19624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19624
agtgtgggag gacccaggct                                                   20


<210> 19625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19625
ggtcaagtgt gggaggaccc                                                   20


<210> 19626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19626
aggtcaagtg tgggaggacc                                                   20


<210> 19627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19627
ttcaggaggt caagtgtggg                                                   20


<210> 19628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19628
gttcaggagg tcaagtgtgg                                                   20


<210> 19629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19629
gggttcagga ggtcaagtgt                                                   20


<210> 19630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19630
tgggttcagg aggtcaagtg                                                   20


<210> 19631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19631
gacactgggt tcaggaggtc                                                   20


<210> 19632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19632
atgtggacac tgggttcagg                                                   20


<210> 19633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19633
catgtggaca ctgggttcag                                                   20


<210> 19634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19634
gacatgtgga cactgggttc                                                   20


<210> 19635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19635
agacatgtgg acactgggtt                                                   20


<210> 19636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19636
gcaggagaca tgtggacact                                                   20


<210> 19637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19637
tgcaggagac atgtggacac                                                   20


<210> 19638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19638
gcagcagtgc aggagacatg                                                   20


<210> 19639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19639
agagcagagc agcagtgcag                                                   20


<210> 19640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19640
tgagagcaga gcagcagtgc                                                   20


<210> 19641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19641
ctgagagcag agcagcagtg                                                   20


<210> 19642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19642
gttagctgag agcagagcag                                                   20


<210> 19643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19643
ccagttagct gagagcagag                                                   20


<210> 19644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19644
gagccagtta gctgagagca                                                   20


<210> 19645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19645
ttgagccagt tagctgagag                                                   20


<210> 19646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19646
gtgttgagcc agttagctga                                                   20


<210> 19647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19647
gtgtgttgag ccagttagct                                                   20


<210> 19648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19648
ggttagtgtg ttgagccagt                                                   20


<210> 19649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19649
tattggttag tgtgttgagc                                                   20


<210> 19650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19650
cccttattgg ttagtgtgtt                                                   20


<210> 19651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19651
tggggcatgc ccttattggt                                                   20


<210> 19652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19652
ggggtggggc atgcccttat                                                   20


<210> 19653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19653
ggtgcagttc gggtggggtg                                                   20


<210> 19654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19654
gggtgcagtt cgggtggggt                                                   20


<210> 19655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19655
agggtgcagt tcgggtgggg                                                   20


<210> 19656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19656
ggcagggtgc agttcgggtg                                                   20


<210> 19657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19657
tggcagggtg cagttcgggt                                                   20


<210> 19658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19658
atggcagggt gcagttcggg                                                   20


<210> 19659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19659
atgatggcag ggtgcagttc                                                   20


<210> 19660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 19660
gatgatggca gggtgcagtt                                                   20


<210> 19661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19661
gtggggatga tggcagggtg                                                   20


<210> 19662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19662
gcggggtggg gatgatggca                                                   20


<210> 19663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19663
ggcggggtgg ggatgatggc                                                   20


<210> 19664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19664
gggcggggtg gggatgatgg                                                   20


<210> 19665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19665
tcggggcggg gtggggatga                                                   20


<210> 19666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19666
ggcgtggtcg gggcggggtg                                                   20


<210> 19667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19667
tggcgtggtc ggggcggggt                                                   20


<210> 19668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19668
ctggcgtggt cggggcgggg                                                   20


<210> 19669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19669
tcactggcgt ggtcggggcg                                                   20


<210> 19670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19670
ctcactggcg tggtcggggc                                                   20


<210> 19671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 19671
cctcactggc gtggtcgggg                                                   20


<210> 19672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19672
tgccctcact ggcgtggtcg                                                   20


<210> 19673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19673
ctgccctcac tggcgtggtc                                                   20


<210> 19674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 19674
actgccctca ctggcgtggt                                                   20


<210> 19675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19675
tggtactgcc ctcactggcg                                                   20


<210> 19676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19676
ctggctggta ctgccctcac                                                   20


<210> 19677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19677
aacatcgtga gtgctctggc                                                   20


<210> 19678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19678
aggcaacatc gtgagtgctc                                                   20


<210> 19679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19679
ctccagatag gcaacatcgt                                                   20


<210> 19680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19680
ttcgaagcca tgctccagat                                                   20


<210> 19681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19681
cttcgaagcc atgctccaga                                                   20


<210> 19682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19682
ctaccttcga agccatgctc                                                   20


<210> 19683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19683
tggcatgagc cctaccttcg                                                   20


<210> 19684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19684
gccatggagc accatggcat                                                   20


<210> 19685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19685
ttcatggcca tggagcacca                                                   20


<210> 19686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19686
acaccatctt catggccatg                                                   20


<210> 19687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19687
gaacaccatc ttcatggcca                                                   20


<210> 19688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19688
cgtggtgaac accatcttca                                                   20


<210> 19689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19689
caccatcacc ttgtgcatcg                                                   20


<210> 19690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19690
ttgtgacgga tccctttgca                                                   20


<210> 19691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19691
gcttgtgacg gatccctttg                                                   20


<210> 19692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 19692
aattctcttt gggcttgtga                                                   20


<210> 19693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19693
agctcaagac aattctcttt                                                   20


<210> 19694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19694
aagctcaaga caattctctt                                                   20


<210> 19695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19695
gccccatgtg ggtgaagctc                                                   20


<210> 19696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19696
attgctgccc catgtgggtg                                                   20


<210> 19697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19697
ctgggattgc tgccccatgt                                                   20


<210> 19698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19698
tctgggattg ctgccccatg                                                   20


<210> 19699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19699
gtctcagaag tatctgatct                                                   20


<210> 19700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19700
tgtctcagaa gtatctgatc                                                   20


<210> 19701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19701
gcttgaccag cttgtctcag                                                   20


<210> 19702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19702
cctgcttgac cagcttgtct                                                   20


<210> 19703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19703
aagtgcccac cctgcttgac                                                   20


<210> 19704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19704
aactcgagga gtctgaacag                                                   20


<210> 19705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19705
cagaactcga ggagtctgaa                                                   20


<210> 19706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19706
actataatgc agaactcgag                                                   20


<210> 19707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19707
acactataat gcagaactcg                                                   20


<210> 19708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19708
cacactataa tgcagaactc                                                   20


<210> 19709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19709
tcattgacca cactataatg                                                   20


<210> 19710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19710
ccaaggtgac acatggctga                                                   20


<210> 19711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19711
ttggggtcca aggtgacaca                                                   20


<210> 19712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19712
gaccgcagaa ttggggtcca                                                   20


<210> 19713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19713
tgaccgcaga attggggtcc                                                   20


<210> 19714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19714
agaggatgac cgcagaattg                                                   20


<210> 19715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19715
tagaggatga ccgcagaatt                                                   20


<210> 19716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19716
ctagaggatg accgcagaat                                                   20


<210> 19717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19717
caaggtctag aggatgaccg                                                   20


<210> 19718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19718
ttattaacaa caaggtctag                                                   20


<210> 19719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19719
attattaaca acaaggtcta                                                   20


<210> 19720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19720
ttattattaa caacaaggtc                                                   20


<210> 19721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19721
ggtacttatt attaacaaca                                                   20


<210> 19722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19722
tggtacttat tattaacaac                                                   20


<210> 19723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19723
tgaagtcaaa atgttggagg                                                   20


<210> 19724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19724
ggctgaagtc aaaatgttgg                                                   20


<210> 19725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19725
gggctgaagt caaaatgttg                                                   20


<210> 19726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19726
gagggctgaa gtcaaaatgt                                                   20


<210> 19727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19727
cagagacaga gagagggctg                                                   20


<210> 19728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19728
gaataccaga gacagagaga                                                   20


<210> 19729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19729
tgaataccag agacagagag                                                   20


<210> 19730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19730
atgaatacca gagacagaga                                                   20


<210> 19731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19731
aaatgaatac cagagacaga                                                   20


<210> 19732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19732
ggaaatgaat accagagaca                                                   20


<210> 19733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19733
taggaaatga ataccagaga                                                   20


<210> 19734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19734
aatataggaa atgaatacca                                                   20


<210> 19735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19735
aaaatatagg aaatgaatac                                                   20


<210> 19736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19736
actaaaggag ttcaaaatat                                                   20


<210> 19737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19737
gactaaagga gttcaaaata                                                   20


<210> 19738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19738
ttggagttgc aggactaaag                                                   20


<210> 19739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19739
aattggagtt gcaggactaa                                                   20


<210> 19740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19740
taattggagt tgcaggacta                                                   20


<210> 19741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19741
cagatattaa ttggagttgc                                                   20


<210> 19742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19742
gcagatatta attggagttg                                                   20


<210> 19743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19743
gatggggcag atattaattg                                                   20


<210> 19744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19744
tggatggggc agatattaat                                                   20


<210> 19745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19745
gtttaaagga ctggatgggg                                                   20


<210> 19746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19746
gcagtttaaa ggactggatg                                                   20


<210> 19747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19747
agcagtttaa aggactggat                                                   20


<210> 19748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19748
cagcagttta aaggactgga                                                   20


<210> 19749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19749
atgtcagcag tttaaaggac                                                   20


<210> 19750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19750
atgtaatgtc agcagtttaa                                                   20


<210> 19751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19751
tatgtaatgt cagcagttta                                                   20


<210> 19752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19752
gtaaaaatat gtaatgtcag                                                   20


<210> 19753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19753
gcagtaaaaa tatgtaatgt                                                   20


<210> 19754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19754
gacatgatat aggtgatggg                                                   20


<210> 19755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19755
aaggacatga tataggtgat                                                   20


<210> 19756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19756
taaggacatg atataggtga                                                   20


<210> 19757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19757
gagaagtaag gacatgatat                                                   20


<210> 19758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19758
tgagaagtaa ggacatgata                                                   20


<210> 19759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19759
gctgggcaaa ttgagaagta                                                   20


<210> 19760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19760
agctgggcaa attgagaagt                                                   20


<210> 19761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19761
tctaagctgg gcaaattgag                                                   20


<210> 19762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19762
aaatctaagc tgggcaaatt                                                   20


<210> 19763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19763
atggatgtga aatctaagct                                                   20


<210> 19764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19764
gatggatgtg aaatctaagc                                                   20


<210> 19765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19765
gagagatgga tgtgaaatct                                                   20


<210> 19766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19766
caagggagta gttagagaga                                                   20


<210> 19767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19767
cctacaaggg agtagttaga                                                   20


<210> 19768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19768
tgcctacaag ggagtagtta                                                   20


<210> 19769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19769
ggtgcctaca agggagtagt                                                   20


<210> 19770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19770
tgagggtgcc tacaagggag                                                   20


<210> 19771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19771
aattgagggt gcctacaagg                                                   20


<210> 19772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19772
ggaattgagg gtgcctacaa                                                   20


<210> 19773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19773
aggaattgag ggtgcctaca                                                   20


<210> 19774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19774
aaggaattga gggtgcctac                                                   20


<210> 19775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19775
gagaggggca aaggaattga                                                   20


<210> 19776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19776
ggagaggggc aaaggaattg                                                   20


<210> 19777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19777
aggagagggg caaaggaatt                                                   20


<210> 19778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19778
atgaaggagg agaggggcaa                                                   20


<210> 19779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19779
aatgaaggag gagaggggca                                                   20


<210> 19780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19780
agtacaatga aggaggagag                                                   20


<210> 19781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19781
aagtacaatg aaggaggaga                                                   20


<210> 19782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19782
caagtacaat gaaggaggag                                                   20


<210> 19783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19783
gcaagtacaa tgaaggagga                                                   20


<210> 19784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19784
aggcaagtac aatgaaggag                                                   20


<210> 19785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19785
ccaggcaagt acaatgaagg                                                   20


<210> 19786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19786
gccaggcaag tacaatgaag                                                   20


<210> 19787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19787
ttgccaggca agtacaatga                                                   20


<210> 19788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19788
tttgccaggc aagtacaatg                                                   20


<210> 19789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19789
cagttcaggt tttgccaggc                                                   20


<210> 19790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19790
ttcacagttc aggttttgcc                                                   20


<210> 19791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19791
attcacagtt caggttttgc                                                   20


<210> 19792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19792
attgggtcta ttcacagttc                                                   20


<210> 19793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19793
aattgggtct attcacagtt                                                   20


<210> 19794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19794
ctacaaattg ggtctattca                                                   20


<210> 19795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19795
tacagagtag tctacaaatt                                                   20


<210> 19796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19796
gtacagagta gtctacaaat                                                   20


<210> 19797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19797
ggttgggtgc aagtacagag                                                   20


<210> 19798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19798
gctggttggg tgcaagtaca                                                   20


<210> 19799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19799
cagctggttg ggtgcaagta                                                   20


<210> 19800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19800
aggtccagct ggttgggtgc                                                   20


<210> 19801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19801
ccagccaggt ccagctggtt                                                   20


<210> 19802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19802
tccagccagg tccagctggt                                                   20


<210> 19803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19803
tttttccagc caggtccagc                                                   20


<210> 19804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19804
gtattttttc cagccaggtc                                                   20


<210> 19805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19805
gttgtgtatt ttttccagcc                                                   20


<210> 19806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19806
agttgtgtat tttttccagc                                                   20


<210> 19807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19807
gcatagttgt gtattttttc                                                   20


<210> 19808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19808
tctaggaggg ttggtaagca                                                   20


<210> 19809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19809
agatctctag gagggttggt                                                   20


<210> 19810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19810
tcacagatct ctaggagggt                                                   20


<210> 19811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19811
gggctcacag atctctagga                                                   20


<210> 19812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19812
ggggctcaca gatctctagg                                                   20


<210> 19813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19813
tggggctcac agatctctag                                                   20


<210> 19814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19814
gctggggctc acagatctct                                                   20


<210> 19815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19815
ggctggggct cacagatctc                                                   20


<210> 19816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19816
cagggcaagg ctggggctca                                                   20


<210> 19817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19817
ttctgggcag ggcaaggctg                                                   20


<210> 19818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19818
tttctgggca gggcaaggct                                                   20


<210> 19819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19819
atttctgggc agggcaaggc                                                   20


<210> 19820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19820
ccagatttct gggcagggca                                                   20


<210> 19821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19821
gccagatttc tgggcagggc                                                   20


<210> 19822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19822
cacagccaga tttctgggca                                                   20


<210> 19823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19823
acacagccag atttctgggc                                                   20


<210> 19824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19824
aacacagcca gatttctggg                                                   20


<210> 19825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19825
agaaacacag ccagatttct                                                   20


<210> 19826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19826
tagaaacaca gccagatttc                                                   20


<210> 19827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19827
atataatata gaaacacagc                                                   20


<210> 19828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19828
tggaatataa tatagaaaca                                                   20


<210> 19829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19829
tgaaggaatg gaatataata                                                   20


<210> 19830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19830
catctggaag aatgaaggaa                                                   20


<210> 19831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19831
acagtcatct ggaagaatga                                                   20


<210> 19832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19832
aacagtcatc tggaagaatg                                                   20


<210> 19833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19833
agtgagaaac agtcatctgg                                                   20


<210> 19834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19834
ggaagtgaga aacagtcatc                                                   20


<210> 19835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19835
ggggaagagg aagtgagaaa                                                   20


<210> 19836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19836
tagacggggg aagaggaagt                                                   20


<210> 19837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19837
aggttagacg ggggaagagg                                                   20


<210> 19838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19838
cggaggttag acgggggaag                                                   20


<210> 19839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19839
ccggaggtta gacgggggaa                                                   20


<210> 19840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19840
agccggaggt tagacggggg                                                   20


<210> 19841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19841
aagagccgga ggttagacgg                                                   20


<210> 19842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19842
gaagagccgg aggttagacg                                                   20


<210> 19843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19843
agaagagccg gaggttagac                                                   20


<210> 19844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 19844
aagaagagcc ggaggttaga                                                   20


<210> 19845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19845
tagaaagaag agccggaggt                                                   20


<210> 19846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19846
taagtagaaa gaagagccgg                                                   20


<210> 19847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19847
gtaagtagaa agaagagccg                                                   20


<210> 19848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 19848
gagtaagtag aaagaagagc                                                   20


<210> 19849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19849
cagagagtaa gtagaaagaa                                                   20


<210> 19850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19850
aacagagagt aagtagaaag                                                   20


<210> 19851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19851
atcaacagag agtaagtaga                                                   20


<210> 19852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19852
gctcatcaac agagagtaag                                                   20


<210> 19853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19853
ggagctcatc aacagagagt                                                   20


<210> 19854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19854
aaagggagct catcaacaga                                                   20


<210> 19855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19855
taaaagggag ctcatcaaca                                                   20


<210> 19856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19856
aataaaaggg agctcatcaa                                                   20


<210> 19857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19857
attctgagtg aaataaaagg                                                   20


<210> 19858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19858
atattctgag tgaaataaaa                                                   20


<210> 19859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19859
tatattctga gtgaaataaa                                                   20


<210> 19860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19860
ctatattctg agtgaaataa                                                   20


<210> 19861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19861
tgtgaactag tctatattct                                                   20


<210> 19862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19862
ggggaagttc ttttgtgaac                                                   20


<210> 19863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19863
ttagtggtag gaagaagggg                                                   20


<210> 19864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19864
gatttagtgg taggaagaag                                                   20


<210> 19865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19865
agatttagtg gtaggaagaa                                                   20


<210> 19866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19866
gagatttagt ggtaggaaga                                                   20


<210> 19867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19867
agagatttag tggtaggaag                                                   20


<210> 19868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19868
gccagagatt tagtggtagg                                                   20


<210> 19869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19869
tatgccagag atttagtggt                                                   20


<210> 19870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19870
atatgccaga gatttagtgg                                                   20


<210> 19871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19871
cagatatgcc agagatttag                                                   20


<210> 19872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19872
ttgcagatat gccagagatt                                                   20


<210> 19873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19873
gtggacttgc agatatgcca                                                   20


<210> 19874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19874
aggtggactt gcagatatgc                                                   20


<210> 19875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19875
cagaatacca ggtggacttg                                                   20


<210> 19876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19876
cacgaagaca gaataccagg                                                   20


<210> 19877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19877
gggcacgaag acagaatacc                                                   20


<210> 19878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19878
ggggcacgaa gacagaatac                                                   20


<210> 19879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19879
cactgtgtgg ggcacgaaga                                                   20


<210> 19880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19880
cacgcactgt gtggggcacg                                                   20


<210> 19881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19881
agccacccac gcactgtgtg                                                   20


<210> 19882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19882
gagccaccca cgcactgtgt                                                   20


<210> 19883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19883
agagccaccc acgcactgtg                                                   20


<210> 19884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19884
cggcacaagt gggaggggta                                                   20


<210> 19885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19885
cccggcacaa gtgggagggg                                                   20


<210> 19886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19886
gagcccggca caagtgggag                                                   20


<210> 19887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19887
agagcccggc acaagtggga                                                   20


<210> 19888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19888
aagagcccgg cacaagtggg                                                   20


<210> 19889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19889
aaagagcccg gcacaagtgg                                                   20


<210> 19890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19890
ggaaagagcc cggcacaagt                                                   20


<210> 19891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19891
aggaaagagc ccggcacaag                                                   20


<210> 19892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19892
gagaggaaag agcccggcac                                                   20


<210> 19893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 19893
aggtgggaga ggaaagagcc                                                   20


<210> 19894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19894
tgaataggtg ggagaggaaa                                                   20


<210> 19895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19895
cttgaatagg tgggagagga                                                   20


<210> 19896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19896
aggccttgaa taggtgggag                                                   20


<210> 19897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19897
caggccttga ataggtggga                                                   20


<210> 19898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19898
tgcaggcctt gaataggtgg                                                   20


<210> 19899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19899
gatgcaggcc ttgaataggt                                                   20


<210> 19900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19900
tgatgcaggc cttgaatagg                                                   20


<210> 19901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19901
ggatgatgca ggccttgaat                                                   20


<210> 19902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19902
tggatgatgc aggccttgaa                                                   20


<210> 19903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19903
gagacaggtc tggatgatgc                                                   20


<210> 19904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19904
ggagacaggt ctggatgatg                                                   20


<210> 19905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19905
gtctggaagg gagacaggtc                                                   20


<210> 19906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19906
caatggtctg gaagggagac                                                   20


<210> 19907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19907
gcaatggtct ggaagggaga                                                   20


<210> 19908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19908
catggcaatg gtctggaagg                                                   20


<210> 19909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19909
ctcatggcaa tggtctggaa                                                   20


<210> 19910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19910
gctcatggca atggtctgga                                                   20


<210> 19911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19911
tgctcatggc aatggtctgg                                                   20


<210> 19912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19912
acctgctcat ggcaatggtc                                                   20


<210> 19913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19913
tgtttacctg ctcatggcaa                                                   20


<210> 19914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19914
aaagcatgtt tacctgctca                                                   20


<210> 19915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19915
tcaaagccgc gagataatta                                                   20


<210> 19916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19916
agagactttt tcaaagccgc                                                   20


<210> 19917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19917
ggtccagaga gactttttca                                                   20


<210> 19918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19918
aagagagcat ggggtccaga                                                   20


<210> 19919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19919
gaaagagagc atggggtcca                                                   20


<210> 19920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19920
atgaaagaga gcatggggtc                                                   20


<210> 19921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19921
cagtaatgaa agagagcatg                                                   20


<210> 19922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19922
gcagtaatga aagagagcat                                                   20


<210> 19923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19923
agcagtaatg aaagagagca                                                   20


<210> 19924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19924
aaagaagcag taatgaaaga                                                   20


<210> 19925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19925
tcaaagaagc agtaatgaaa                                                   20


<210> 19926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19926
tgtcaaagaa gcagtaatga                                                   20


<210> 19927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19927
gaattttact gtcaaagaag                                                   20


<210> 19928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19928
aaggaatttt actgtcaaag                                                   20


<210> 19929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19929
tgcaaggaat tttactgtca                                                   20


<210> 19930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19930
aagtgtagaa aactcttgca                                                   20


<210> 19931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19931
taagtgtaga aaactcttgc                                                   20


<210> 19932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19932
gagctgtaga aggttaagtg                                                   20


<210> 19933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19933
gtaaggagct gtagaaggtt                                                   20


<210> 19934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19934
aagaggtaag gagctgtaga                                                   20


<210> 19935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19935
aaagaggtaa ggagctgtag                                                   20


<210> 19936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19936
aaaaaagagg taaggagctg                                                   20


<210> 19937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19937
cagagaaaaa aagaggtaag                                                   20


<210> 19938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19938
tgcagagaaa aaaagaggta                                                   20


<210> 19939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19939
ctgcagagaa aaaaagaggt                                                   20


<210> 19940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19940
ggggctgcag agaaaaaaag                                                   20


<210> 19941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19941
aggggctgca gagaaaaaaa                                                   20


<210> 19942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19942
ccaggggctg cagagaaaaa                                                   20


<210> 19943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19943
gtcagattcc aggggctgca                                                   20


<210> 19944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19944
aagtcagatt ccaggggctg                                                   20


<210> 19945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19945
cagttaaagt cagattccag                                                   20


<210> 19946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19946
gcagttaaag tcagattcca                                                   20


<210> 19947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19947
agcagttaaa gtcagattcc                                                   20


<210> 19948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19948
aagcagttaa agtcagattc                                                   20


<210> 19949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19949
aatttggaag cagttaaagt                                                   20


<210> 19950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19950
tttgaatttg gaagcagtta                                                   20


<210> 19951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19951
caattatttg aatttggaag                                                   20


<210> 19952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19952
aatcaattat ttgaatttgg                                                   20


<210> 19953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19953
ggaaatcaat tatttgaatt                                                   20


<210> 19954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19954
tataagggta agatgagaac                                                   20


<210> 19955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19955
aaatgttata agggtaagat                                                   20


<210> 19956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19956
ctgtcaaatg ttataagggt                                                   20


<210> 19957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19957
aattctgtca aatgttataa                                                   20


<210> 19958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19958
aaattctgtc aaatgttata                                                   20


<210> 19959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19959
taaattctgt caaatgttat                                                   20


<210> 19960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19960
aaatgaacac tggtttcaaa                                                   20


<210> 19961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19961
ccaaatgaac actggtttca                                                   20


<210> 19962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19962
ccccagagcc aaatgaacac                                                   20


<210> 19963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19963
aagagatgat gcagtcccca                                                   20


<210> 19964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19964
gcaagagatg atgcagtccc                                                   20


<210> 19965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19965
agaaaaagca agagatgatg                                                   20


<210> 19966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19966
aaatatggga gaaaaagcaa                                                   20


<210> 19967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19967
agaaatatgg gagaaaaagc                                                   20


<210> 19968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19968
gtggagaaat atgggagaaa                                                   20


<210> 19969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19969
aaagaagtgg agaaatatgg                                                   20


<210> 19970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19970
gaaaagaagt ggagaaatat                                                   20


<210> 19971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19971
tgaaaagaag tggagaaata                                                   20


<210> 19972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19972
acagaaagtg aaaagaagtg                                                   20


<210> 19973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19973
aaacagaaag tgaaaagaag                                                   20


<210> 19974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19974
caaaaacaga aagtgaaaag                                                   20


<210> 19975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19975
agacaaaaac agaaagtgaa                                                   20


<210> 19976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19976
aaaagggaga caaaaacaga                                                   20


<210> 19977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19977
aaggaaaagg gagacaaaaa                                                   20


<210> 19978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19978
acaagcagga aaggaaaagg                                                   20


<210> 19979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19979
ttacaagcag gaaaggaaaa                                                   20


<210> 19980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19980
tttacaagca ggaaaggaaa                                                   20


<210> 19981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19981
atttacaagc aggaaaggaa                                                   20


<210> 19982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19982
tcaacattta caagcaggaa                                                   20


<210> 19983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19983
ttcaacattt acaagcagga                                                   20


<210> 19984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19984
gttattcaac atttacaagc                                                   20


<210> 19985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19985
agttattcaa catttacaag                                                   20


<210> 19986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19986
ttgagttatt caacatttac                                                   20


<210> 19987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19987
aagctaaggt gagaatgctt                                                   20


<210> 19988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19988
aaacacagag aagctaaggt                                                   20


<210> 19989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19989
tcaaaaacac agagaagcta                                                   20


<210> 19990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19990
ttcaaaaaca cagagaagct                                                   20


<210> 19991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 19991
tgagattcaa aaacacagag                                                   20


<210> 19992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19992
ctatgagatt caaaaacaca                                                   20


<210> 19993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 19993
ggctatgaga ttcaaaaaca                                                   20


<210> 19994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19994
agatggtttt ttagggctat                                                   20


<210> 19995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 19995
ggcatagaga tggtttttta                                                   20


<210> 19996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 19996
tggcatagag atggtttttt                                                   20


<210> 19997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 19997
ttggcataga gatggttttt                                                   20


<210> 19998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 19998
ggtgggaatt ggcatagaga                                                   20


<210> 19999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 19999
atttggtggg aattggcata                                                   20


<210> 20000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20000
taatttggtg ggaattggca                                                   20


<210> 20001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20001
acacataatt tggtgggaat                                                   20


<210> 20002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20002
aattggacac ataatttggt                                                   20


<210> 20003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20003
aaattggaca cataatttgg                                                   20


<210> 20004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20004
cagaaattgg acacataatt                                                   20


<210> 20005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20005
ttcaggaagg gatcagaaat                                                   20


<210> 20006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20006
cctagtgttc aggaagggat                                                   20


<210> 20007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20007
ataagcctag tgttcaggaa                                                   20


<210> 20008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20008
gataagccta gtgttcagga                                                   20


<210> 20009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20009
agataagcct agtgttcagg                                                   20


<210> 20010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20010
gagagataag cctagtgttc                                                   20


<210> 20011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20011
agagagataa gcctagtgtt                                                   20


<210> 20012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20012
ggcaggtaga gagataagcc                                                   20


<210> 20013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20013
acggaggcag gtagagagat                                                   20


<210> 20014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20014
atttaacgga ggcaggtaga                                                   20


<210> 20015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20015
agatttaacg gaggcaggta                                                   20


<210> 20016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20016
ggagatttaa cggaggcagg                                                   20


<210> 20017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20017
catggagatt taacggaggc                                                   20


<210> 20018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20018
acatggagat ttaacggagg                                                   20


<210> 20019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20019
tccacatgga gatttaacgg                                                   20


<210> 20020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20020
atccacatgg agatttaacg                                                   20


<210> 20021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 20021
acatccacat ggagatttaa                                                   20


<210> 20022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20022
cacagttaca catccacatg                                                   20


<210> 20023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20023
aacacagtta cacatccaca                                                   20


<210> 20024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20024
gccctccatc gaggtgaaca                                                   20


<210> 20025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20025
taagaaattg ccctccatcg                                                   20


<210> 20026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20026
ctaagaaatt gccctccatc                                                   20


<210> 20027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20027
ttatagataa acctaaagct                                                   20


<210> 20028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20028
ggaatttata gataaaccta                                                   20


<210> 20029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20029
atgtcttgcc gaggaattta                                                   20


<210> 20030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20030
tcaagatgca tgtcttgccg                                                   20


<210> 20031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20031
ttcaagatgc atgtcttgcc                                                   20


<210> 20032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20032
acataggctg atatctgttc                                                   20


<210> 20033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20033
tcatctttct ttgcccacat                                                   20


<210> 20034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20034
atcatctttc tttgcccaca                                                   20


<210> 20035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20035
tccattatta ttataaacaa                                                   20


<210> 20036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20036
cacaatgtat tatgctttat                                                   20


<210> 20037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20037
gcaatgttct atgcatatat                                                   20


<210> 20038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20038
cagtttatct tatattcttc                                                   20


<210> 20039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20039
ggtgcacccc cctcccactc                                                   20


<210> 20040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20040
cttcctgctc cccagactcc                                                   20


<210> 20041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20041
tatagaccct tcctgctccc                                                   20


<210> 20042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20042
actatgtctc cttcccacta                                                   20


<210> 20043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20043
aaaaaaaccc taaacactgc                                                   20


<210> 20044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20044
actgattttt caagtgcata                                                   20


<210> 20045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20045
tttctctaaa ctgatttttc                                                   20


<210> 20046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20046
tagcaaaatt tgggggcaca                                                   20


<210> 20047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20047
acactgttag caaaatttgg                                                   20


<210> 20048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20048
aacactgtta gcaaaatttg                                                   20


<210> 20049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20049
aaacactgtt agcaaaattt                                                   20


<210> 20050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20050
aaaacactgt tagcaaaatt                                                   20


<210> 20051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20051
ttatcaggaa aaaacactgt                                                   20


<210> 20052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20052
atacacattt ttaaattatc                                                   20


<210> 20053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20053
catacacatt tttaaattat                                                   20


<210> 20054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20054
atgaagaaaa ttgaaaaaaa                                                   20


<210> 20055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20055
aaatttaaaa taaaaaaatg                                                   20


<210> 20056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20056
cttaaagtat aatttaaaaa                                                   20


<210> 20057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20057
cacatttacc ctaaaactta                                                   20


<210> 20058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20058
gtaaggcatg tatgcatatg                                                   20


<210> 20059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20059
tgagaaaagc ttcatatgta                                                   20


<210> 20060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20060
gtgagaaaag cttcatatgt                                                   20


<210> 20061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20061
tccaagcctt gtagtgagaa                                                   20


<210> 20062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20062
tattttccaa gccttgtagt                                                   20


<210> 20063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20063
aaggtatttt ccaagccttg                                                   20


<210> 20064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20064
acatggagaa ggtattttcc                                                   20


<210> 20065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20065
gaaagaaaaa aacatggaga                                                   20


<210> 20066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20066
agaaagaaaa aaacatggag                                                   20


<210> 20067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20067
aaaagaaaga aaaaaacatg                                                   20


<210> 20068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20068
acaaaagaaa gaaaaaaaca                                                   20


<210> 20069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20069
aaaagtgaaa ctacaaaaga                                                   20


<210> 20070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20070
tgaaaaaagt gaaactacaa                                                   20


<210> 20071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20071
accaaagttt taagtgaaaa                                                   20


<210> 20072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20072
ttcaaatgca ccaaagtttt                                                   20


<210> 20073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20073
aataaatttc aaatgcacca                                                   20


<210> 20074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20074
tgatataaat aatcagagac                                                   20


<210> 20075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20075
ttgatataaa taatcagaga                                                   20


<210> 20076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20076
aatgttgata taaataatca                                                   20


<210> 20077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20077
gtaatgttga tataaataat                                                   20


<210> 20078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20078
aaaatgaaaa attattcaat                                                   20


<210> 20079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20079
aaaatgacat ttcaaatctt                                                   20


<210> 20080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20080
aaaaatgaca tttcaaatct                                                   20


<210> 20081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20081
tgaaaacaca tgaacataaa                                                   20


<210> 20082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20082
tctgatctgt ggaagagaaa                                                   20


<210> 20083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20083
aaatagtctg atctgtggaa                                                   20


<210> 20084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20084
ataaatagtc tgatctgtgg                                                   20


<210> 20085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20085
aaaataaata gtctgatctg                                                   20


<210> 20086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20086
agcatgacag tgaaaataaa                                                   20


<210> 20087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20087
cagtgattaa aacagcatga                                                   20


<210> 20088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20088
aatccagtca gtgattaaaa                                                   20


<210> 20089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20089
tgtagtttct aaaatccagt                                                   20


<210> 20090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20090
catctgtagt ttctaaaatc                                                   20


<210> 20091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20091
tttgccagtt tggacatctg                                                   20


<210> 20092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20092
agaactatgc tttgccagtt                                                   20


<210> 20093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20093
tttagagaac tatgctttgc                                                   20


<210> 20094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20094
aggatgtgcc aacttcttta                                                   20


<210> 20095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20095
ccaggatgtg ccaacttctt                                                   20


<210> 20096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20096
ggattgttga ttttggtccc                                                   20


<210> 20097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20097
gggattgttg attttggtcc                                                   20


<210> 20098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20098
caaacaggga ttgttgattt                                                   20


<210> 20099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20099
tcttgctttt gttccaaaca                                                   20


<210> 20100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20100
ttcttgcttt tgttccaaac                                                   20


<210> 20101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20101
gttcttgctt ttgttccaaa                                                   20


<210> 20102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20102
gtgccaaaat aggtccaggg                                                   20


<210> 20103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20103
ttagtgccaa aataggtcca                                                   20


<210> 20104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20104
tttagtgcca aaataggtcc                                                   20


<210> 20105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20105
ttttagtgcc aaaataggtc                                                   20


<210> 20106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20106
cttcttttta gtgccaaaat                                                   20


<210> 20107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20107
gcttcttttt agtgccaaaa                                                   20


<210> 20108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20108
ctacttcctg tgcttctttt                                                   20


<210> 20109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20109
ctgccaaaat ggcacatcta                                                   20


<210> 20110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20110
gtggctgctt cctgccaaaa                                                   20


<210> 20111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20111
ttcccatcat gcctcacagg                                                   20


<210> 20112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20112
cttttcccat catgcctcac                                                   20


<210> 20113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20113
tcttttccca tcatgcctca                                                   20


<210> 20114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20114
caatgtcaag gctgtttaca                                                   20


<210> 20115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20115
aatcaagttc aacaatgtca                                                   20


<210> 20116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20116
caatcaagtt caacaatgtc                                                   20


<210> 20117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20117
ctgtgtctct gcaatcaatc                                                   20


<210> 20118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20118
agctggcaag tagatacttt                                                   20


<210> 20119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20119
tcatgtttta agctggcaag                                                   20


<210> 20120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20120
tggtcatgtt ttaagctggc                                                   20


<210> 20121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20121
gccatggtca tgttttaagc                                                   20


<210> 20122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20122
tggggccatg gtcatgtttt                                                   20


<210> 20123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20123
atccttttga ggtggggcca                                                   20


<210> 20124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20124
taggagatcc ttttgaggtg                                                   20


<210> 20125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20125
ataggagatc cttttgaggt                                                   20


<210> 20126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20126
tataggagat ccttttgagg                                                   20


<210> 20127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20127
ttatatagga gatccttttg                                                   20


<210> 20128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20128
tttatatagg agatcctttt                                                   20


<210> 20129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20129
ctgttatcaa ttttatatag                                                   20


<210> 20130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20130
ctctgttatc aattttatat                                                   20


<210> 20131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20131
tctctgttat caattttata                                                   20


<210> 20132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20132
gtaacaggat gaagggagga                                                   20


<210> 20133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20133
aagcgtaaca ggatgaaggg                                                   20


<210> 20134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20134
taagcgtaac aggatgaagg                                                   20


<210> 20135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20135
tttaagcgta acaggatgaa                                                   20


<210> 20136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20136
ctttaagcgt aacaggatga                                                   20


<210> 20137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20137
tctttaagcg taacaggatg                                                   20


<210> 20138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20138
gggacctctt taagcgtaac                                                   20


<210> 20139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20139
ggggacctct ttaagcgtaa                                                   20


<210> 20140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20140
aggagcaggg ggacctcttt                                                   20


<210> 20141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20141
ctggtgttaa caggagcagg                                                   20


<210> 20142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20142
actggtgtta acaggagcag                                                   20


<210> 20143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20143
cactggtgtt aacaggagca                                                   20


<210> 20144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20144
acactggtgt taacaggagc                                                   20


<210> 20145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20145
gacactggtg ttaacaggag                                                   20


<210> 20146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20146
ggagacactg gtgttaacag                                                   20


<210> 20147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20147
gtggagacac tggtgttaac                                                   20


<210> 20148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20148
agtggagaca ctggtgttaa                                                   20


<210> 20149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20149
agaatgcaca gtggagacac                                                   20


<210> 20150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20150
gcaggagaga atgcacagtg                                                   20


<210> 20151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20151
tggcaggaga gaatgcacag                                                   20


<210> 20152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20152
cagtggcagg agagaatgca                                                   20


<210> 20153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20153
agactcctgc agtggcagga                                                   20


<210> 20154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20154
acagactcct gcagtggcag                                                   20


<210> 20155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20155
caacagactc ctgcagtggc                                                   20


<210> 20156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20156
tcaacagact cctgcagtgg                                                   20


<210> 20157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20157
tattcaacag actcctgcag                                                   20


<210> 20158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20158
gtatattcaa cagactcctg                                                   20


<210> 20159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20159
ggaagaaagg gtatattcaa                                                   20


<210> 20160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20160
ctgaagatta agggaagaaa                                                   20


<210> 20161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20161
actgaagatt aagggaagaa                                                   20


<210> 20162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20162
gactgaagat taagggaaga                                                   20


<210> 20163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20163
gagagactga agattaaggg                                                   20


<210> 20164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20164
taagagagac tgaagattaa                                                   20


<210> 20165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20165
ataagagaga ctgaagatta                                                   20


<210> 20166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20166
aataagagag actgaagatt                                                   20


<210> 20167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20167
tgggagaata agagagactg                                                   20


<210> 20168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20168
aaggatctgg gagaataaga                                                   20


<210> 20169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20169
ggaaggatct gggagaataa                                                   20


<210> 20170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20170
tgggaaggat ctgggagaat                                                   20


<210> 20171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20171
tgctaatggg aaggatctgg                                                   20


<210> 20172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20172
catgctaatg ggaaggatct                                                   20


<210> 20173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20173
gcatgctaat gggaaggatc                                                   20


<210> 20174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20174
atatttgcat gctaatggga                                                   20


<210> 20175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20175
catatttgca tgctaatggg                                                   20


<210> 20176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20176
gagcatattt gcatgctaat                                                   20


<210> 20177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20177
tgagcatatt tgcatgctaa                                                   20


<210> 20178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20178
tttgtttgtt tgtttgtttt                                                   20


<210> 20179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20179
tttggttttt gtgtttgggg                                                   20


<210> 20180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20180
tttttggttt ttgtgtttgg                                                   20


<210> 20181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20181
ctttttggtt tttgtgtttg                                                   20


<210> 20182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20182
actttttggt ttttgtgttt                                                   20


<210> 20183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20183
gactttttgg tttttgtgtt                                                   20


<210> 20184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20184
agaattgaaa gaagactttt                                                   20


<210> 20185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20185
ggagtaggga gaattgaaag                                                   20


<210> 20186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20186
tagggagtag ggagaattga                                                   20


<210> 20187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20187
agatggcact agggagtagg                                                   20


<210> 20188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20188
taagatggca ctagggagta                                                   20


<210> 20189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20189
gtaagatggc actagggagt                                                   20


<210> 20190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20190
agtaagatgg cactagggag                                                   20


<210> 20191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20191
gatagtaaga tggcactagg                                                   20


<210> 20192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20192
gagatagtaa gatggcacta                                                   20


<210> 20193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20193
ggagatagta agatggcact                                                   20


<210> 20194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20194
aggagatagt aagatggcac                                                   20


<210> 20195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20195
aggaaaagga gatagtaaga                                                   20


<210> 20196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20196
tgtgaggaaa aggagatagt                                                   20


<210> 20197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20197
tgcctgtgag gaaaaggaga                                                   20


<210> 20198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20198
agtttgcctg tgaggaaaag                                                   20


<210> 20199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20199
gaagtttgcc tgtgaggaaa                                                   20


<210> 20200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20200
agaagtttgc ctgtgaggaa                                                   20


<210> 20201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20201
tttcaagaag tttgcctgtg                                                   20


<210> 20202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20202
ttttcaagaa gtttgcctgt                                                   20


<210> 20203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20203
gtacagacaa ttttttcaag                                                   20


<210> 20204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20204
ggtgtacaga caattttttc                                                   20


<210> 20205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20205
agaaatggag atatggtgta                                                   20


<210> 20206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20206
gaggtgaaga aatggagata                                                   20


<210> 20207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20207
gggtgagagg tgaagaaatg                                                   20


<210> 20208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20208
gcgggtgaga ggtgaagaaa                                                   20


<210> 20209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20209
taaagagcgg gtgagaggtg                                                   20


<210> 20210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20210
gggcttaaag agcgggtgag                                                   20


<210> 20211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20211
ggggcttaaa gagcgggtga                                                   20


<210> 20212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20212
aaggggctta aagagcgggt                                                   20


<210> 20213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20213
attgaagggg cttaaagagc                                                   20


<210> 20214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 20214
tattgaaggg gcttaaagag                                                   20


<210> 20215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20215
tcatattgaa ggggcttaaa                                                   20


<210> 20216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20216
ggtcatattg aaggggctta                                                   20


<210> 20217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20217
aggcagaggt catattgaag                                                   20


<210> 20218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20218
taggcagagg tcatattgaa                                                   20


<210> 20219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20219
gtaggcagag gtcatattga                                                   20


<210> 20220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20220
ggtaggcaga ggtcatattg                                                   20


<210> 20221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20221
tggagtaaaa gggtaggcag                                                   20


<210> 20222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20222
atggagtaaa agggtaggca                                                   20


<210> 20223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20223
taatggagta aaagggtagg                                                   20


<210> 20224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20224
gattaatgga gtaaaagggt                                                   20


<210> 20225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20225
ggattaatgg agtaaaaggg                                                   20


<210> 20226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20226
agaggattaa tggagtaaaa                                                   20


<210> 20227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20227
aagaggatta atggagtaaa                                                   20


<210> 20228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20228
aaagaggatt aatggagtaa                                                   20


<210> 20229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20229
taagcaaaag aggattaatg                                                   20


<210> 20230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20230
tctaagcaaa agaggattaa                                                   20


<210> 20231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20231
tttggtgatc taagcaaaag                                                   20


<210> 20232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20232
ctttggtgat ctaagcaaaa                                                   20


<210> 20233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20233
gtctttggtg atctaagcaa                                                   20


<210> 20234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20234
atggatgtct ttggtgatct                                                   20


<210> 20235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20235
tttagtcaca tggatgtctt                                                   20


<210> 20236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20236
gtccaggggc tttagtcaca                                                   20


<210> 20237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20237
atgaaaaggt ccaggggctt                                                   20


<210> 20238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20238
tgaaacatga aaaggtccag                                                   20


<210> 20239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20239
atgaaacatg aaaaggtcca                                                   20


<210> 20240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20240
aatgaaacat gaaaaggtcc                                                   20


<210> 20241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20241
aaatgaaaca tgaaaaggtc                                                   20


<210> 20242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20242
aggtaaaatg aaacatgaaa                                                   20


<210> 20243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20243
caggtaaaat gaaacatgaa                                                   20


<210> 20244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20244
ggcaatgctg tggaaaggtc                                                   20


<210> 20245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20245
aggcaatgct gtggaaaggt                                                   20


<210> 20246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20246
acagaggcaa tgctgtggaa                                                   20


<210> 20247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20247
aacagaggca atgctgtgga                                                   20


<210> 20248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20248
ggccaacaga ggcaatgctg                                                   20


<210> 20249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20249
aagaatagaa aggccaacag                                                   20


<210> 20250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20250
aaagaataga aaggccaaca                                                   20


<210> 20251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20251
agaaagaata gaaaggccaa                                                   20


<210> 20252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20252
tttcttcaga aagaatagaa                                                   20


<210> 20253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20253
atttcttcag aaagaataga                                                   20


<210> 20254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20254
aaaaatttct tcagaaagaa                                                   20


<210> 20255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20255
agagtaaaaa tttcttcaga                                                   20


<210> 20256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20256
gccaagagta aaaatttctt                                                   20


<210> 20257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20257
agaatacaat gcagagccaa                                                   20


<210> 20258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20258
gaagaataca atgcagagcc                                                   20


<210> 20259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20259
atctagaaga atacaatgca                                                   20


<210> 20260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20260
agatctagaa gaatacaatg                                                   20


<210> 20261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20261
agaaatagga aaagatctag                                                   20


<210> 20262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20262
tacagaaata ggaaaagatc                                                   20


<210> 20263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20263
ggaaggtaca gaaataggaa                                                   20


<210> 20264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20264
gaaaaggaag gtacagaaat                                                   20


<210> 20265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20265
tgaaaaggaa ggtacagaaa                                                   20


<210> 20266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20266
ggagactgaa aaggaaggta                                                   20


<210> 20267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20267
gcagaggaga ctgaaaagga                                                   20


<210> 20268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20268
agcagaggag actgaaaagg                                                   20


<210> 20269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20269
cccagcagag gagactgaaa                                                   20


<210> 20270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20270
acccagcaga ggagactgaa                                                   20


<210> 20271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20271
aagagatgga cccagcagag                                                   20


<210> 20272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20272
agaagagatg gacccagcag                                                   20


<210> 20273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20273
cagaagagat ggacccagca                                                   20


<210> 20274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20274
agcagaagag atggacccag                                                   20


<210> 20275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20275
ttaagcagaa gagatggacc                                                   20


<210> 20276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20276
taatagttaa gcagaagaga                                                   20


<210> 20277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20277
tgtttaatag ttaagcagaa                                                   20


<210> 20278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20278
aatgtttaat agttaagcag                                                   20


<210> 20279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20279
ctaaatgttt aatagttaag                                                   20


<210> 20280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20280
aaactaaatg tttaatagtt                                                   20


<210> 20281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20281
ctaacaaact aaatgtttaa                                                   20


<210> 20282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20282
agagaagaag gcctcagaca                                                   20


<210> 20283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20283
gtaagaagag aagaaggcct                                                   20


<210> 20284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20284
gttgaagtaa gaagagaaga                                                   20


<210> 20285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20285
ggttgaagta agaagagaag                                                   20


<210> 20286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20286
aagggttgaa gtaagaagag                                                   20


<210> 20287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20287
cagaagggtt gaagtaagaa                                                   20


<210> 20288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20288
cacagaaggg ttgaagtaag                                                   20


<210> 20289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20289
taacacagaa gggttgaagt                                                   20


<210> 20290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20290
gagttaacac agaagggttg                                                   20


<210> 20291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20291
ctggatgagt taacacagaa                                                   20


<210> 20292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20292
actggatgag ttaacacaga                                                   20


<210> 20293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20293
aactggatga gttaacacag                                                   20


<210> 20294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20294
tgcaactgga tgagttaaca                                                   20


<210> 20295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20295
ttgaaaagat gcaactggat                                                   20


<210> 20296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20296
taattttgaa aagatgcaac                                                   20


<210> 20297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20297
atgtaagtgg taattttgaa                                                   20


<210> 20298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20298
gaaagcagtt tgaatgtaag                                                   20


<210> 20299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20299
tttgaaagca gtttgaatgt                                                   20


<210> 20300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20300
tatatatata tatttgaaag                                                   20


<210> 20301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20301
atgtatatat atatatttga                                                   20


<210> 20302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20302
tagaacttag atgacaaaga                                                   20


<210> 20303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20303
ggtctagaac ttagatgaca                                                   20


<210> 20304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20304
ggatataggg gtctagaact                                                   20


<210> 20305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20305
gactttagga tataggggtc                                                   20


<210> 20306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20306
aagttgactt taggatatag                                                   20


<210> 20307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20307
gaagttgact ttaggatata                                                   20


<210> 20308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20308
ggaagttgac tttaggatat                                                   20


<210> 20309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20309
aggaagttga ctttaggata                                                   20


<210> 20310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20310
tccagtagga agttgacttt                                                   20


<210> 20311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20311
gtccagtagg aagttgactt                                                   20


<210> 20312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20312
aggtaggggt gtccagtagg                                                   20


<210> 20313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20313
tctaggtagg ggtgtccagt                                                   20


<210> 20314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20314
atctaggtag gggtgtccag                                                   20


<210> 20315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20315
agcatctagg taggggtgtc                                                   20


<210> 20316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20316
cccttggagc atctaggtag                                                   20


<210> 20317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20317
gcccttggag catctaggta                                                   20


<210> 20318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20318
tgcccttgga gcatctaggt                                                   20


<210> 20319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20319
gtgcccttgg agcatctagg                                                   20


<210> 20320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20320
caggtgccct tggagcatct                                                   20


<210> 20321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20321
tcaggtgccc ttggagcatc                                                   20


<210> 20322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20322
ttgggtttca ggtgcccttg                                                   20


<210> 20323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20323
tattgggttt caggtgccct                                                   20


<210> 20324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20324
tctgggatat attgggtttc                                                   20


<210> 20325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20325
gtctgggata tattgggttt                                                   20


<210> 20326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20326
agttgagtct gggatatatt                                                   20


<210> 20327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20327
gagttgagtc tgggatatat                                                   20


<210> 20328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20328
gaagattatg agttgagtct                                                   20


<210> 20329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20329
agaagattat gagttgagtc                                                   20


<210> 20330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20330
atgaaagaag attatgagtt                                                   20


<210> 20331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20331
gaaagatgaa agaagattat                                                   20


<210> 20332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20332
ttaatgggga aagatgaaag                                                   20


<210> 20333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20333
gctttaatgg ggaaagatga                                                   20


<210> 20334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20334
gaagggggct ttaatgggga                                                   20


<210> 20335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20335
ggaagaaggg ggctttaatg                                                   20


<210> 20336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20336
gggaagaagg gggctttaat                                                   20


<210> 20337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20337
ggggaagaag ggggctttaa                                                   20


<210> 20338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20338
agcattttag gggaagaagg                                                   20


<210> 20339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20339
gagcatttta ggggaagaag                                                   20


<210> 20340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20340
ggagcatttt aggggaagaa                                                   20


<210> 20341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20341
gggagcattt taggggaaga                                                   20


<210> 20342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20342
agggagcatt ttaggggaag                                                   20


<210> 20343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20343
taaagggagc attttagggg                                                   20


<210> 20344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20344
tcataaaggg agcattttag                                                   20


<210> 20345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20345
ctcataaagg gagcatttta                                                   20


<210> 20346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20346
actcataaag ggagcatttt                                                   20


<210> 20347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20347
aactcataaa gggagcattt                                                   20


<210> 20348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20348
gatacaataa ctcataaagg                                                   20


<210> 20349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20349
ctgatacaat aactcataaa                                                   20


<210> 20350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20350
gctgatacaa taactcataa                                                   20


<210> 20351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20351
tgctgataca ataactcata                                                   20


<210> 20352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20352
ggttctggta taagtgcctt                                                   20


<210> 20353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20353
gatgcatatg gttctggtat                                                   20


<210> 20354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20354
cttgatgatg catatggttc                                                   20


<210> 20355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20355
tcaggacttg atgatgcata                                                   20


<210> 20356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20356
atctaagggg cataagattc                                                   20


<210> 20357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20357
tatctaaggg gcataagatt                                                   20


<210> 20358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20358
gagagctatc taaggggcat                                                   20


<210> 20359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20359
ggatatgaga gctatctaag                                                   20


<210> 20360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20360
aggatatgag agctatctaa                                                   20


<210> 20361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20361
aaggatatga gagctatcta                                                   20


<210> 20362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20362
gaaggatatg agagctatct                                                   20


<210> 20363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20363
tgggaaatgg aaggatatga                                                   20


<210> 20364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20364
gatgggaaat ggaaggatat                                                   20


<210> 20365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20365
tggggctgat gggaaatgga                                                   20


<210> 20366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20366
gtggggctga tgggaaatgg                                                   20


<210> 20367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20367
acagtggggc tgatgggaaa                                                   20


<210> 20368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20368
gtagtgacag tggggctgat                                                   20


<210> 20369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20369
ggtagtgaca gtggggctga                                                   20


<210> 20370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20370
actctggggt agtgacagtg                                                   20


<210> 20371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20371
aactctgggg tagtgacagt                                                   20


<210> 20372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20372
gaactctggg gtagtgacag                                                   20


<210> 20373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20373
cttgaactct ggggtagtga                                                   20


<210> 20374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20374
gcagtgcttg aactctgggg                                                   20


<210> 20375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20375
atggcagtgc ttgaactctg                                                   20


<210> 20376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20376
gatggcagtg cttgaactct                                                   20


<210> 20377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20377
agatggcagt gcttgaactc                                                   20


<210> 20378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20378
ggaagccaag tacaagatgg                                                   20


<210> 20379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20379
ggaggaagcc aagtacaaga                                                   20


<210> 20380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20380
gttaggagga agccaagtac                                                   20


<210> 20381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20381
aaaccagtta ggaggaagcc                                                   20


<210> 20382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20382
cagggaaacc agttaggagg                                                   20


<210> 20383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20383
tgtcagggaa accagttagg                                                   20


<210> 20384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20384
ttgtcaggga aaccagttag                                                   20


<210> 20385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20385
tgttgtcagg gaaaccagtt                                                   20


<210> 20386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20386
atgttgtcag ggaaaccagt                                                   20


<210> 20387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20387
aagtatgttg tcagggaaac                                                   20


<210> 20388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20388
agaggggaag tatgttgtca                                                   20


<210> 20389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20389
aagaggggaa gtatgttgtc                                                   20


<210> 20390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20390
taagagggga agtatgttgt                                                   20


<210> 20391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20391
acttgtagat ataagagggg                                                   20


<210> 20392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20392
gatacttgta gatataagag                                                   20


<210> 20393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20393
ggatacttgt agatataaga                                                   20


<210> 20394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20394
tggatacttg tagatataag                                                   20


<210> 20395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20395
ctggatactt gtagatataa                                                   20


<210> 20396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20396
ctctggatac ttgtagatat                                                   20


<210> 20397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20397
aaagttactc tggatacttg                                                   20


<210> 20398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20398
gcattttata aaagttactc                                                   20


<210> 20399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20399
gttacatttg cattttataa                                                   20


<210> 20400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20400
ttaaaggatt ggaggcaggg                                                   20


<210> 20401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20401
ccattaaagg attggaggca                                                   20


<210> 20402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20402
gccattaaag gattggaggc                                                   20


<210> 20403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20403
tgccattaaa ggattggagg                                                   20


<210> 20404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20404
aggtgccatt aaaggattgg                                                   20


<210> 20405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20405
gaggtgccat taaaggattg                                                   20


<210> 20406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20406
gtgaggtgcc attaaaggat                                                   20


<210> 20407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20407
gaggagtgag gtgccattaa                                                   20


<210> 20408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20408
agaggagtga ggtgccatta                                                   20


<210> 20409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20409
acttcatgct aagaggagtg                                                   20


<210> 20410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20410
gacttcatgc taagaggagt                                                   20


<210> 20411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20411
atgggacttc atgctaagag                                                   20


<210> 20412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20412
atatgggact tcatgctaag                                                   20


<210> 20413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20413
gatatgggac ttcatgctaa                                                   20


<210> 20414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20414
aggatatggg acttcatgct                                                   20


<210> 20415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20415
ctagactgca ttaaggatat                                                   20


<210> 20416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20416
cctagactgc attaaggata                                                   20


<210> 20417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20417
gaaactccta gactgcatta                                                   20


<210> 20418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20418
agaaactcct agactgcatt                                                   20


<210> 20419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20419
gccagatccc aagaaactcc                                                   20


<210> 20420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20420
atgagttggg gccagatccc                                                   20


<210> 20421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20421
ctagagggat gagttggggc                                                   20


<210> 20422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20422
aaggctagag ggatgagttg                                                   20


<210> 20423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20423
taaggctaga gggatgagtt                                                   20


<210> 20424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20424
ataaggctag agggatgagt                                                   20


<210> 20425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20425
gaaaataagg ctagagggat                                                   20


<210> 20426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20426
gaactgaaaa taaggctaga                                                   20


<210> 20427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20427
agaactgaaa ataaggctag                                                   20


<210> 20428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20428
gagaactgaa aataaggcta                                                   20


<210> 20429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20429
aggagaactg aaaataaggc                                                   20


<210> 20430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20430
aaccaggaga actgaaaata                                                   20


<210> 20431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20431
gaaccaggag aactgaaaat                                                   20


<210> 20432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20432
gctgtaacct agagaaccag                                                   20


<210> 20433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20433
tagctgtaac ctagagaacc                                                   20


<210> 20434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20434
gtagctgtaa cctagagaac                                                   20


<210> 20435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20435
cctaatgtag ctgtaaccta                                                   20


<210> 20436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20436
agcctaatgt agctgtaacc                                                   20


<210> 20437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20437
aggaatgaaa aagcctaatg                                                   20


<210> 20438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20438
taacatttga aggaatgaaa                                                   20


<210> 20439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20439
gaagagagaa taacatttga                                                   20


<210> 20440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20440
agaagagaga ataacatttg                                                   20


<210> 20441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20441
aaggactgca aagcagaaga                                                   20


<210> 20442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20442
gaaaggactg caaagcagaa                                                   20


<210> 20443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20443
ctgaaaggac tgcaaagcag                                                   20


<210> 20444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20444
aggctgaaag gactgcaaag                                                   20


<210> 20445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20445
cccaggctga aaggactgca                                                   20


<210> 20446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20446
gggaattatc ccaggctgaa                                                   20


<210> 20447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20447
agggaattat cccaggctga                                                   20


<210> 20448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20448
tggagccagg gaattatccc                                                   20


<210> 20449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20449
ctggagccag ggaattatcc                                                   20


<210> 20450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20450
gtaagatttg cctggagcca                                                   20


<210> 20451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20451
ggtaagattt gcctggagcc                                                   20


<210> 20452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20452
tggtaagatt tgcctggagc                                                   20


<210> 20453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20453
aatatggtaa gatttgcctg                                                   20


<210> 20454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20454
gaaatatggt aagatttgcc                                                   20


<210> 20455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20455
gatactaagt gaaatatggt                                                   20


<210> 20456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20456
gcaggatact aagtgaaata                                                   20


<210> 20457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20457
aagaggaagt gcaggatact                                                   20


<210> 20458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20458
gtgccttaaa gaggaagtgc                                                   20


<210> 20459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20459
agtgccttaa agaggaagtg                                                   20


<210> 20460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20460
tggtgagtgc cttaaagagg                                                   20


<210> 20461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20461
gagtggtgag tgccttaaag                                                   20


<210> 20462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20462
ggagtggtga gtgccttaaa                                                   20


<210> 20463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20463
ctggagtggt gagtgcctta                                                   20


<210> 20464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20464
agtgagctta ctggagtggt                                                   20


<210> 20465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20465
cagcagtgag cttactggag                                                   20


<210> 20466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20466
tcacagcagt gagcttactg                                                   20


<210> 20467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20467
ggtcacagca gtgagcttac                                                   20


<210> 20468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20468
agaagctggg tcacagcagt                                                   20


<210> 20469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20469
ttccagaagc tgggtcacag                                                   20


<210> 20470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20470
gaattccaga agctgggtca                                                   20


<210> 20471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20471
aagccagaat tccagaagct                                                   20


<210> 20472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20472
caagccagaa ttccagaagc                                                   20


<210> 20473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20473
tgtccaagcc agaattccag                                                   20


<210> 20474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20474
tgttgtccaa gccagaattc                                                   20


<210> 20475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20475
gatttcactg ttgtccaagc                                                   20


<210> 20476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20476
ctgagatttc actgttgtcc                                                   20


<210> 20477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20477
ctatgcttgg catgcaagct                                                   20


<210> 20478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20478
accttctatg cttggcatgc                                                   20


<210> 20479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20479
gcatgtgaac cttctatgct                                                   20


<210> 20480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20480
ttgacaattc actgaactca                                                   20


<210> 20481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20481
agtttggccc aaaccaacag                                                   20


<210> 20482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20482
aaagtttggc ccaaaccaac                                                   20


<210> 20483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20483
gaaagtttgg cccaaaccaa                                                   20


<210> 20484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20484
ggattatgct taagaaagtt                                                   20


<210> 20485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20485
aagagggatt atgcttaaga                                                   20


<210> 20486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20486
ctttaagagg gattatgctt                                                   20


<210> 20487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20487
taaaggccac ctctttaaga                                                   20


<210> 20488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20488
ataaaggcca cctctttaag                                                   20


<210> 20489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20489
tataaaggcc acctctttaa                                                   20


<210> 20490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20490
tttataaagg ccacctcttt                                                   20


<210> 20491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20491
agtcgtaata ggatttataa                                                   20


<210> 20492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20492
gagtcgtaat aggatttata                                                   20


<210> 20493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20493
catgctgcca gagtcgtaat                                                   20


<210> 20494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20494
tcatgctgcc agagtcgtaa                                                   20


<210> 20495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20495
aaggatgctt catgctgcca                                                   20


<210> 20496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20496
tgaaggatgc ttcatgctgc                                                   20


<210> 20497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20497
tacacacatg agacacctga                                                   20


<210> 20498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20498
ttacacacat gagacacctg                                                   20


<210> 20499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20499
gttatattca ttacacacat                                                   20


<210> 20500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20500
ggcacatcat cttctctggt                                                   20


<210> 20501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20501
atagggcaca tcatcttctc                                                   20


<210> 20502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20502
gtcaaagttt tctgagcata                                                   20


<210> 20503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20503
ggtcaaagtt ttctgagcat                                                   20


<210> 20504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20504
aggtcaaagt tttctgagca                                                   20


<210> 20505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20505
aaaagaggtc aaagttttct                                                   20


<210> 20506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20506
aggttaaata aaagaggtca                                                   20


<210> 20507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20507
aaccttaggt taaataaaag                                                   20


<210> 20508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20508
aaaccttagg ttaaataaaa                                                   20


<210> 20509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20509
ggaaacctta ggttaaataa                                                   20


<210> 20510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20510
atctgaggag aggaaacctt                                                   20


<210> 20511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20511
aatctgagga gaggaaacct                                                   20


<210> 20512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20512
tttaaagaaa atctgaggag                                                   20


<210> 20513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20513
ttttaaagaa aatctgagga                                                   20


<210> 20514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20514
tgttttaaag aaaatctgag                                                   20


<210> 20515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20515
gatgttttaa agaaaatctg                                                   20


<210> 20516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20516
tgatgtttta aagaaaatct                                                   20


<210> 20517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20517
agagaaacaa tgatgtttta                                                   20


<210> 20518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20518
cagtagagta agaaaggcca                                                   20


<210> 20519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20519
gacagtagag taagaaaggc                                                   20


<210> 20520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20520
ctgtgacagt agagtaagaa                                                   20


<210> 20521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20521
gctgtgacag tagagtaaga                                                   20


<210> 20522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20522
agatgctgtg acagtagagt                                                   20


<210> 20523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20523
aggaagatgc tgtgacagta                                                   20


<210> 20524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20524
caaggaagat gctgtgacag                                                   20


<210> 20525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20525
cctcaaggaa gatgctgtga                                                   20


<210> 20526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20526
gggtagactt cccctcaagg                                                   20


<210> 20527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20527
gtagggtaga cttcccctca                                                   20


<210> 20528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20528
ggtagggtag acttcccctc                                                   20


<210> 20529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20529
gcaaatatgt tggggtaggg                                                   20


<210> 20530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20530
taggcaaata tgttggggta                                                   20


<210> 20531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20531
ataggcaaat atgttggggt                                                   20


<210> 20532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20532
aataggcaaa tatgttgggg                                                   20


<210> 20533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20533
agtaataggc aaatatgttg                                                   20


<210> 20534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20534
aagtaatagg caaatatgtt                                                   20


<210> 20535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20535
taagtaatag gcaaatatgt                                                   20


<210> 20536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20536
aaaggaagaa aataagtaat                                                   20


<210> 20537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20537
aaaaggaaga aaataagtaa                                                   20


<210> 20538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20538
ctgataaaaa ggaagaaaat                                                   20


<210> 20539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20539
agtgtgaact gataaaaagg                                                   20


<210> 20540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20540
aacagtgtga actgataaaa                                                   20


<210> 20541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20541
taacagtgtg aactgataaa                                                   20


<210> 20542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20542
ggagtgatgc taatttataa                                                   20


<210> 20543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20543
atttgggtgg ttggcggcgg                                                   20


<210> 20544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20544
atatttgggt ggttggcggc                                                   20


<210> 20545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 20545
gatatttggg tggttggcgg                                                   20


<210> 20546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 20546
ggtgatattt gggtggttgg                                                   20


<210> 20547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20547
aaaggtgata tttgggtggt                                                   20


<210> 20548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20548
gcacaaaggt gatatttggg                                                   20


<210> 20549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20549
catgcacaaa ggtgatattt                                                   20


<210> 20550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20550
gcatgcacaa aggtgatatt                                                   20


<210> 20551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20551
gaagacaagt gcatgcacaa                                                   20


<210> 20552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20552
agaagacaag tgcatgcaca                                                   20


<210> 20553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20553
acctccatta cccagaagac                                                   20


<210> 20554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20554
gcctgacctc cattacccag                                                   20


<210> 20555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20555
acagcctgac ctccattacc                                                   20


<210> 20556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20556
agatgtgtct gttttgctca                                                   20


<210> 20557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20557
ttgtaaaatc tatgagggcg                                                   20


<210> 20558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 20558
ggttgtaaaa tctatgaggg                                                   20


<210> 20559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20559
ctaggttgta aaatctatga                                                   20


<210> 20560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20560
actaggttgt aaaatctatg                                                   20


<210> 20561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20561
tactaggttg taaaatctat                                                   20


<210> 20562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20562
tttggctatt atgatttact                                                   20


<210> 20563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20563
atttggctat tatgatttac                                                   20


<210> 20564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20564
tagtaaatac tcatcacatt                                                   20


<210> 20565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20565
ttagaaccac gactggcatg                                                   20


<210> 20566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20566
aaaatgctta gaaccacgac                                                   20


<210> 20567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20567
gtcaggtcaa gcaaaatgct                                                   20


<210> 20568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20568
aggattaaat gagtcaggtc                                                   20


<210> 20569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20569
ttgtgaggat taaatgagtc                                                   20


<210> 20570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20570
tttgtgagga ttaaatgagt                                                   20


<210> 20571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20571
gagttttgtg aggattaaat                                                   20


<210> 20572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20572
ttatcttgta gagttttgtg                                                   20


<210> 20573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20573
cttatcttgt agagttttgt                                                   20


<210> 20574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20574
gagaatatac ttatcttgta                                                   20


<210> 20575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20575
gtgagaatat acttatcttg                                                   20


<210> 20576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20576
tttttagcct gtaaagtagt                                                   20


<210> 20577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20577
cagattttta gcctgtaaag                                                   20


<210> 20578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20578
cctcagattt ttagcctgta                                                   20


<210> 20579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20579
ttttctgtgc ctcagatttt                                                   20


<210> 20580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20580
tcagtaactt ttctgtgcct                                                   20


<210> 20581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20581
acagtgtgac cttggagctt                                                   20


<210> 20582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20582
tggtacacag tgtgaccttg                                                   20


<210> 20583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20583
tatggtacac agtgtgacct                                                   20


<210> 20584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20584
gctcttccac ttatggtaca                                                   20


<210> 20585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20585
catcctagct cttccactta                                                   20


<210> 20586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20586
ggctgcctgg gtttgcatcc                                                   20


<210> 20587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20587
gctctggaac ccggctgcct                                                   20


<210> 20588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20588
tgctctggaa cccggctgcc                                                   20


<210> 20589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 20589
tagaacactg ctctggaacc                                                   20


<210> 20590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20590
tagtagttag aacactgctc                                                   20


<210> 20591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20591
aggcaacaga gggtagtagt                                                   20


<210> 20592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20592
tgagaggcaa cagagggtag                                                   20


<210> 20593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20593
gaatgagagg caacagaggg                                                   20


<210> 20594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20594
gatgaatgag aggcaacaga                                                   20


<210> 20595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20595
ggatgaatga gaggcaacag                                                   20


<210> 20596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20596
gggatgaatg agaggcaaca                                                   20


<210> 20597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20597
atgggatgaa tgagaggcaa                                                   20


<210> 20598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20598
aaggtcatgg gatgaatgag                                                   20


<210> 20599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20599
gaaggtcatg ggatgaatga                                                   20


<210> 20600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20600
aagaaggtca tgggatgaat                                                   20


<210> 20601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20601
gtaagacaaa agaaggtcat                                                   20


<210> 20602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20602
ggtaagacaa aagaaggtca                                                   20


<210> 20603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20603
agtgtaggta agacaaaaga                                                   20


<210> 20604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20604
cagtgtaggt aagacaaaag                                                   20


<210> 20605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20605
tcccagtgta ggtaagacaa                                                   20


<210> 20606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20606
aaacacatcc cagtgtaggt                                                   20


<210> 20607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20607
tcccaaacac atcccagtgt                                                   20


<210> 20608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20608
gtcccaaaca catcccagtg                                                   20


<210> 20609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20609
tgcatgtccc aaacacatcc                                                   20


<210> 20610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20610
tgcaagaatg agatagcaac                                                   20


<210> 20611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20611
tgcattctgc aagaatgaga                                                   20


<210> 20612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20612
acaatgcatt ctgcaagaat                                                   20


<210> 20613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20613
gcaagtacaa tgcattctgc                                                   20


<210> 20614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20614
agttcgcaga cacaaatagc                                                   20


<210> 20615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20615
agaaagttcg cagacacaaa                                                   20


<210> 20616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20616
gaagctgagg agaaagttcg                                                   20


<210> 20617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20617
tatgtaagaa gctgaggaga                                                   20


<210> 20618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20618
cagctatgta agaagctgag                                                   20


<210> 20619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20619
atcagctatg taagaagctg                                                   20


<210> 20620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20620
aatcagctat gtaagaagct                                                   20


<210> 20621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20621
aaaggaatca gctatgtaag                                                   20


<210> 20622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20622
aataaaggaa tcagctatgt                                                   20


<210> 20623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20623
tttgaattaa ataaaggaat                                                   20


<210> 20624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20624
cagaaatttg aattaaataa                                                   20


<210> 20625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20625
acagaaattt gaattaaata                                                   20


<210> 20626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20626
aaaattctct ccaagaagaa                                                   20


<210> 20627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20627
gatggaaaat tctctccaag                                                   20


<210> 20628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20628
ggagatggaa aattctctcc                                                   20


<210> 20629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20629
aaataaagta ggaaaggaga                                                   20


<210> 20630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20630
gaaaaaataa agtaggaaag                                                   20


<210> 20631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20631
gagaaaaaat aaagtaggaa                                                   20


<210> 20632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20632
ggagaaaaaa taaagtagga                                                   20


<210> 20633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20633
agtaggagaa aaaataaagt                                                   20


<210> 20634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20634
aagtaggaga aaaaataaag                                                   20


<210> 20635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20635
aagaagtagg agaaaaaata                                                   20


<210> 20636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20636
tattcagata taagaagtag                                                   20


<210> 20637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20637
gatattcaga tataagaagt                                                   20


<210> 20638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20638
agatattcag atataagaag                                                   20


<210> 20639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20639
aatagatatt cagatataag                                                   20


<210> 20640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20640
atgaatagat attcagatat                                                   20


<210> 20641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20641
atgaaagatg aatagatatt                                                   20


<210> 20642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20642
aaggggacat gaaagatgaa                                                   20


<210> 20643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20643
tagcagggaa ggggacatga                                                   20


<210> 20644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20644
tctacatcct agcagggaag                                                   20


<210> 20645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20645
atctacatcc tagcagggaa                                                   20


<210> 20646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20646
aatctacatc ctagcaggga                                                   20


<210> 20647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20647
gaatctacat cctagcaggg                                                   20


<210> 20648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20648
atggaatcta catcctagca                                                   20


<210> 20649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20649
catggaatct acatcctagc                                                   20


<210> 20650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20650
tcatggaatc tacatcctag                                                   20


<210> 20651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20651
cgctcatgga atctacatcc                                                   20


<210> 20652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20652
ctgatataag cttgcgctca                                                   20


<210> 20653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20653
attcagtggt gaactgatat                                                   20


<210> 20654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20654
cttcaggtgc tgggattcag                                                   20


<210> 20655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20655
ttgcttcagg tgctgggatt                                                   20


<210> 20656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20656
gtggcattgc ttcaggtgct                                                   20


<210> 20657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20657
tgtggcattg cttcaggtgc                                                   20


<210> 20658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20658
tgtgtgtgtg gcattgcttc                                                   20


<210> 20659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20659
ttgtgtgtgt ggcattgctt                                                   20


<210> 20660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20660
ttgagcccct gttgtgtgtg                                                   20


<210> 20661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20661
cttatcaaca agcatttgtt                                                   20


<210> 20662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20662
tcatttattc tcttatcaac                                                   20


<210> 20663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20663
atttattctc gaaaactgtt                                                   20


<210> 20664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20664
cagcaaacat tgaatacaaa                                                   20


<210> 20665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20665
ttttgctatt agtcatcaaa                                                   20


<210> 20666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20666
tttggttttt gttttgctat                                                   20


<210> 20667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20667
tggtttttgt ttgtttgttt                                                   20


<210> 20668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20668
tcttggccag ataggtttct                                                   20


<210> 20669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20669
aatttctttc ttggccagat                                                   20


<210> 20670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20670
caatttcttt cttggccaga                                                   20


<210> 20671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20671
cccacaattt ctttcttggc                                                   20


<210> 20672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20672
tattcccaca atttctttct                                                   20


<210> 20673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20673
tcatggcata gaatttgacc                                                   20


<210> 20674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20674
ttctaacatt tttcatggca                                                   20


<210> 20675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20675
tgtacttcta acatttttca                                                   20


<210> 20676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20676
tatcactgtt cattgtaata                                                   20


<210> 20677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20677
aatatcactg ttcattgtaa                                                   20


<210> 20678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20678
tttctcaaca acaacgtgta                                                   20


<210> 20679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20679
catacctgag tttgtgcttt                                                   20


<210> 20680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20680
gttacatttc ttgcatacct                                                   20


<210> 20681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20681
agcataaatt gaattcaact                                                   20


<210> 20682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20682
gttcccatgg tgaggacttg                                                   20


<210> 20683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20683
aagagacagt tcccatggtg                                                   20


<210> 20684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20684
caagagacag ttcccatggt                                                   20


<210> 20685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20685
ttaacaagag acagttccca                                                   20


<210> 20686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20686
aacattgact taacaagaga                                                   20


<210> 20687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20687
acccaacatt gacttaacaa                                                   20


<210> 20688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20688
gtacccaaca ttgacttaac                                                   20


<210> 20689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20689
cacagactca gatattgaaa                                                   20


<210> 20690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20690
acaaaactca gacacagact                                                   20


<210> 20691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20691
agccctacaa aactcagaca                                                   20


<210> 20692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20692
ggtttgagcc ctacaaaact                                                   20


<210> 20693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20693
ctcaactctc ctccaggttt                                                   20


<210> 20694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20694
gaccagctca actctcctcc                                                   20


<210> 20695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20695
ggaccagctc aactctcctc                                                   20


<210> 20696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20696
gcttagcaat gacaaaggac                                                   20


<210> 20697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20697
aatacgctta gcaatgacaa                                                   20


<210> 20698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20698
aaatacgctt agcaatgaca                                                   20


<210> 20699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20699
caactcaggc aaaatacgct                                                   20


<210> 20700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20700
ccagatggga gctacaactc                                                   20


<210> 20701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20701
accagatggg agctacaact                                                   20


<210> 20702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20702
tcccaccagg gaccagatgg                                                   20


<210> 20703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20703
tctcccacca gggaccagat                                                   20


<210> 20704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20704
ctctcccacc agggaccaga                                                   20


<210> 20705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20705
tggactctcc caccagggac                                                   20


<210> 20706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20706
cttcatggac tctcccacca                                                   20


<210> 20707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20707
tcttcatgga ctctcccacc                                                   20


<210> 20708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20708
atcttcatgg actctcccac                                                   20


<210> 20709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20709
agagagaaga gccatcttca                                                   20


<210> 20710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20710
gagggaaact agagagagaa                                                   20


<210> 20711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20711
tagagggaaa ctagagagag                                                   20


<210> 20712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20712
ccatagaggg aaactagaga                                                   20


<210> 20713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20713
acccatagag ggaaactaga                                                   20


<210> 20714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20714
agacccatag agggaaacta                                                   20


<210> 20715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20715
tgagacccat agagggaaac                                                   20


<210> 20716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20716
agatgagtga gacccataga                                                   20


<210> 20717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20717
aagatgagtg agacccatag                                                   20


<210> 20718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20718
aaagatgagt gagacccata                                                   20


<210> 20719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20719
aaaaagatga gtgagaccca                                                   20


<210> 20720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20720
ggctatggaa aaagatgagt                                                   20


<210> 20721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20721
tgaaggctat ggaaaaagat                                                   20


<210> 20722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20722
cccagtgaag gctatggaaa                                                   20


<210> 20723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20723
ttagccccca gtgaaggcta                                                   20


<210> 20724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20724
gatgacttag cccccagtga                                                   20


<210> 20725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20725
tgatgactta gcccccagtg                                                   20


<210> 20726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20726
ctgggtgatg acttagcccc                                                   20


<210> 20727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20727
agaggagctg ggtgatgact                                                   20


<210> 20728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20728
cagaatggca gagaggagct                                                   20


<210> 20729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20729
ccagaatggc agagaggagc                                                   20


<210> 20730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20730
ggctccagaa tggcagagag                                                   20


<210> 20731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20731
gtggctccag aatggcagag                                                   20


<210> 20732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20732
tgtggctcca gaatggcaga                                                   20


<210> 20733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20733
cctgtggctc cagaatggca                                                   20


<210> 20734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20734
gccctgtggc tccagaatgg                                                   20


<210> 20735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20735
agagccctgt ggctccagaa                                                   20


<210> 20736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20736
cagagagagc cctgtggctc                                                   20


<210> 20737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20737
cagcctcaga gagagccctg                                                   20


<210> 20738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20738
gcctgaagca gcctcagaga                                                   20


<210> 20739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20739
aggcctgaag cagcctcaga                                                   20


<210> 20740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20740
gaaggcctga agcagcctca                                                   20


<210> 20741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20741
gagaaggcct gaagcagcct                                                   20


<210> 20742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20742
aggttagaga aggcctgaag                                                   20


<210> 20743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20743
cttaggttag agaaggcctg                                                   20


<210> 20744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20744
ggtcaacctt aggttagaga                                                   20


<210> 20745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20745
aggtcaacct taggttagag                                                   20


<210> 20746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20746
cttaggtcaa ccttaggtta                                                   20


<210> 20747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20747
agcttaggtc aaccttaggt                                                   20


<210> 20748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20748
ccttagctta ggtcaacctt                                                   20


<210> 20749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20749
accttagctt aggtcaacct                                                   20


<210> 20750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20750
gggaaaggca accttagctt                                                   20


<210> 20751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20751
ggggaaaggc aaccttagct                                                   20


<210> 20752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20752
aatctgggga aaggcaacct                                                   20


<210> 20753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20753
ttttaagaaa atctggggaa                                                   20


<210> 20754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20754
tttttaagaa aatctgggga                                                   20


<210> 20755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20755
gacgttttta agaaaatctg                                                   20


<210> 20756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20756
agacgttttt aagaaaatct                                                   20


<210> 20757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20757
aagacgtttt taagaaaatc                                                   20


<210> 20758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20758
ggagaaacaa agacgttttt                                                   20


<210> 20759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20759
taagaaaggc aggagaaaca                                                   20


<210> 20760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20760
gagtagagta agaaaggcag                                                   20


<210> 20761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20761
gagagtagag taagaaaggc                                                   20


<210> 20762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20762
tgagagtaga gtaagaaagg                                                   20


<210> 20763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20763
ctgtgagagt agagtaagaa                                                   20


<210> 20764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20764
actgtgagag tagagtaaga                                                   20


<210> 20765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20765
agatactgtg agagtagagt                                                   20


<210> 20766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20766
aggaagatac tgtgagagta                                                   20


<210> 20767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20767
caaggaagat actgtgagag                                                   20


<210> 20768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20768
gctcaaggaa gatactgtga                                                   20


<210> 20769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20769
ccgctcaagg aagatactgt                                                   20


<210> 20770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20770
ggatagactt ccgctcaagg                                                   20


<210> 20771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20771
gtaggataga cttccgctca                                                   20


<210> 20772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20772
ggtaggatag acttccgctc                                                   20


<210> 20773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20773
tcaggtatct tggggtagga                                                   20


<210> 20774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20774
atagtcaggt atcttggggt                                                   20


<210> 20775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20775
aatagtcagg tatcttgggg                                                   20


<210> 20776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20776
aggaatagtc aggtatcttg                                                   20


<210> 20777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20777
aaggaatagt caggtatctt                                                   20


<210> 20778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20778
taaggaatag tcaggtatct                                                   20


<210> 20779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20779
gaagaaaata aggaatagtc                                                   20


<210> 20780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20780
ggaagaaaat aaggaatagt                                                   20


<210> 20781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20781
aaaaggaaga aaataaggaa                                                   20


<210> 20782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20782
tgataaaaag gaagaaaata                                                   20


<210> 20783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20783
ctgataaaaa ggaagaaaat                                                   20


<210> 20784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20784
ggtgtaaact gataaaaagg                                                   20


<210> 20785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20785
agtggtgtaa actgataaaa                                                   20


<210> 20786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20786
tagtggtgta aactgataaa                                                   20


<210> 20787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20787
ggggtgatgc tactttatag                                                   20


<210> 20788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20788
tggggggtga tgctacttta                                                   20


<210> 20789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20789
taacaaaggt gatatctggg                                                   20


<210> 20790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20790
ttaacaaagg tgatatctgg                                                   20


<210> 20791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20791
attaacaaag gtgatatctg                                                   20


<210> 20792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20792
cattaacaaa ggtgatatct                                                   20


<210> 20793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20793
gcattaacaa aggtgatatc                                                   20


<210> 20794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20794
gaagagcagt gcattaacaa                                                   20


<210> 20795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20795
agaagagcag tgcattaaca                                                   20


<210> 20796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20796
atctccatta cctagaagag                                                   20


<210> 20797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20797
tggatctcca ttacctagaa                                                   20


<210> 20798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20798
gctggatctc cattacctag                                                   20


<210> 20799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20799
acagctggat ctccattacc                                                   20


<210> 20800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20800
gtatctgttt tgctcacagc                                                   20


<210> 20801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20801
agatgtatct gttttgctca                                                   20


<210> 20802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20802
agtaatttac cagatatgca                                                   20


<210> 20803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20803
ccagtaattt accagatatg                                                   20


<210> 20804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20804
agaactagcc agtaatttac                                                   20


<210> 20805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20805
aactgtagag tagaactagc                                                   20


<210> 20806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20806
cagaaactgt agagtagaac                                                   20


<210> 20807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20807
catgcacaga aactgtagag                                                   20


<210> 20808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20808
tcacatgcac agaaactgta                                                   20


<210> 20809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20809
attcacatgc acagaaactg                                                   20


<210> 20810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20810
tagagagaga ttcacatgca                                                   20


<210> 20811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20811
gaggtggcaa gccttagaga                                                   20


<210> 20812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20812
cagaggtggc aagccttaga                                                   20


<210> 20813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20813
gccagaggtg gcaagcctta                                                   20


<210> 20814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20814
aagccagagg tggcaagcct                                                   20


<210> 20815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20815
taggtaaagc cagaggtggc                                                   20


<210> 20816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20816
tttctaggta aagccagagg                                                   20


<210> 20817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20817
tactttctag gtaaagccag                                                   20


<210> 20818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20818
ctactttcta ggtaaagcca                                                   20


<210> 20819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20819
ccctactttc taggtaaagc                                                   20


<210> 20820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20820
tgtgccctac tttctaggta                                                   20


<210> 20821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20821
caatgtgtgc cctactttct                                                   20


<210> 20822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20822
ccaatgtgtg ccctactttc                                                   20


<210> 20823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20823
gtttgaggga tttcaaaaca                                                   20


<210> 20824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20824
atgtttgagg gatttcaaaa                                                   20


<210> 20825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20825
gaaaccaaaa aaatgtttga                                                   20


<210> 20826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20826
agaaaccaaa aaaatgtttg                                                   20


<210> 20827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20827
tagaaaccaa aaaaatgttt                                                   20


<210> 20828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20828
ggggaagaag tggtgagcaa                                                   20


<210> 20829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20829
atttgagggg aagaagtggt                                                   20


<210> 20830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20830
cctaatttga ggggaagaag                                                   20


<210> 20831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20831
aatcctaatt tgaggggaag                                                   20


<210> 20832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20832
ctgaatccta atttgagggg                                                   20


<210> 20833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20833
aggctgaatc ctaatttgag                                                   20


<210> 20834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20834
taggctgaat cctaatttga                                                   20


<210> 20835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20835
ctaggctgaa tcctaatttg                                                   20


<210> 20836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20836
cctaggctga atcctaattt                                                   20


<210> 20837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20837
tgtgttttcc tcccagccct                                                   20


<210> 20838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20838
gtgtgttttc ctcccagccc                                                   20


<210> 20839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20839
agtcctgtgt gttttcctcc                                                   20


<210> 20840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20840
gctggtgtgc ccctgagaag                                                   20


<210> 20841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20841
gtgctggtgt gcccctgaga                                                   20


<210> 20842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20842
agtgctggtg tgcccctgag                                                   20


<210> 20843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20843
ttgagtgctg gtgtgcccct                                                   20


<210> 20844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20844
ttgtaaggga gcttgagtgc                                                   20


<210> 20845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20845
gaggagttgt aagggagctt                                                   20


<210> 20846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20846
aggctggagg agttgtaagg                                                   20


<210> 20847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20847
ctaggctgga ggagttgtaa                                                   20


<210> 20848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20848
cctaggctgg aggagttgta                                                   20


<210> 20849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20849
acctaggctg gaggagttgt                                                   20


<210> 20850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20850
taaactgacc taggctggag                                                   20


<210> 20851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20851
attaaactga cctaggctgg                                                   20


<210> 20852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20852
aattaaactg acctaggctg                                                   20


<210> 20853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20853
caaattaaac tgacctaggc                                                   20


<210> 20854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20854
tagacaaatt aaactgacct                                                   20


<210> 20855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20855
ctagacaaat taaactgacc                                                   20


<210> 20856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20856
ttccagttat cttactcccc                                                   20


<210> 20857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20857
aatgcaacct tcatcatttc                                                   20


<210> 20858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20858
tttttttgcc ttagggtatg                                                   20


<210> 20859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20859
cctttttttg ccttagggta                                                   20


<210> 20860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20860
tccagccttt ttttgcctta                                                   20


<210> 20861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20861
atccagcctt tttttgcctt                                                   20


<210> 20862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20862
aatccagcct ttttttgcct                                                   20


<210> 20863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20863
gcaggaggtc tgttctaatc                                                   20


<210> 20864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20864
tccctctaac cttgagcagg                                                   20


<210> 20865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20865
atccctctaa ccttgagcag                                                   20


<210> 20866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20866
gcatccctct aaccttgagc                                                   20


<210> 20867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20867
tgcatccctc taaccttgag                                                   20


<210> 20868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20868
gattgcatcc ctctaacctt                                                   20


<210> 20869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20869
tatccacaca ctttgccata                                                   20


<210> 20870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20870
cctatccaca cactttgcca                                                   20


<210> 20871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20871
gaagagagtg gcaatggtca                                                   20


<210> 20872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20872
gtagaggaag agagtggcaa                                                   20


<210> 20873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20873
caaagggtag aggaagagag                                                   20


<210> 20874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20874
agccaaaggg tagaggaaga                                                   20


<210> 20875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20875
caagccaaag ggtagaggaa                                                   20


<210> 20876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20876
tccaagccaa agggtagagg                                                   20


<210> 20877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20877
agttccaagc caaagggtag                                                   20


<210> 20878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20878
aagttccaag ccaaagggta                                                   20


<210> 20879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20879
ctaagttcca agccaaaggg                                                   20


<210> 20880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20880
tatctaagtt ccaagccaaa                                                   20


<210> 20881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20881
gtatctaagt tccaagccaa                                                   20


<210> 20882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20882
tgtatctaag ttccaagcca                                                   20


<210> 20883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20883
cagcaatgta tctaagttcc                                                   20


<210> 20884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20884
gtctccccag caatgtatct                                                   20


<210> 20885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20885
gggaatccac tcagtctccc                                                   20


<210> 20886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20886
caatcaagtg ggaatccact                                                   20


<210> 20887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20887
tagaattcta ccaatcaagt                                                   20


<210> 20888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20888
ttagaattct accaatcaag                                                   20


<210> 20889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20889
aatttagaat tctaccaatc                                                   20


<210> 20890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20890
taactaagtc cttgttaatt                                                   20


<210> 20891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20891
attaatcagt caatttaact                                                   20


<210> 20892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20892
gacaatttaa gtccattaat                                                   20


<210> 20893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20893
tgaatattgg tagacaattt                                                   20


<210> 20894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20894
cacattatgc tgaatattgg                                                   20


<210> 20895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20895
gcccacatta tgctgaatat                                                   20


<210> 20896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20896
tgtaatttaa tttcttgttc                                                   20


<210> 20897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20897
tttcatggtt gtaacttaca                                                   20


<210> 20898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20898
tttcataatt atatttttca                                                   20


<210> 20899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20899
tggcaaaatt atccttttca                                                   20


<210> 20900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20900
ccatccttaa ttttccaaca                                                   20


<210> 20901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20901
aggccagctc tccggtgtac                                                   20


<210> 20902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 20902
agaatttcag gccagctctc                                                   20


<210> 20903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20903
ggcatcagag aatttcaggc                                                   20


<210> 20904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20904
ggcaggcatc agagaatttc                                                   20


<210> 20905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20905
tggcaggcat cagagaattt                                                   20


<210> 20906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20906
aagtgatctg gcaggcatca                                                   20


<210> 20907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20907
aaaagtgatc tggcaggcat                                                   20


<210> 20908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20908
atttttaaaa gtgatctggc                                                   20


<210> 20909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20909
gatttttaaa agtgatctgg                                                   20


<210> 20910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20910
ctagattttt aaaagtgatc                                                   20


<210> 20911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20911
tcacaaaact agatttttaa                                                   20


<210> 20912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20912
ctttgcatgc atcacaaaac                                                   20


<210> 20913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20913
agctcatctc ttgttcaaat                                                   20


<210> 20914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20914
atttgatgaa taaaatatcc                                                   20


<210> 20915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20915
cttttatcaa tgtggttttt                                                   20


<210> 20916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20916
cccaccatct tttatcaatg                                                   20


<210> 20917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20917
actcctcatt cttatgtctt                                                   20


<210> 20918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20918
tactcctcat tcttatgtct                                                   20


<210> 20919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20919
aagcgtccat ctctgtgtac                                                   20


<210> 20920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20920
aatgtctcta actcgtgtca                                                   20


<210> 20921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20921
aattcccatg tgagcagcag                                                   20


<210> 20922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20922
atgaattccc atgtgagcag                                                   20


<210> 20923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20923
atgatgaatt cccatgtgag                                                   20


<210> 20924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20924
gtcatgatga attcccatgt                                                   20


<210> 20925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20925
taacctccgt ccttgagggt                                                   20


<210> 20926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20926
atcataacct ccgtccttga                                                   20


<210> 20927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20927
tatcataacc tccgtccttg                                                   20


<210> 20928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20928
gtatcataac ctccgtcctt                                                   20


<210> 20929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20929
caaagggcaa tgagtgttgt                                                   20


<210> 20930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20930
ttccgggccc aaagggcaat                                                   20


<210> 20931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20931
tgaacctttc cgggcccaaa                                                   20


<210> 20932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20932
atgaaccttt ccgggcccaa                                                   20


<210> 20933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20933
gatgaacctt tccgggccca                                                   20


<210> 20934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20934
atacttagat gaacctttcc                                                   20


<210> 20935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 20935
aatacttaga tgaacctttc                                                   20


<210> 20936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20936
tttcttgtca gcagaatact                                                   20


<210> 20937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20937
aaagaagact ttcttgtcag                                                   20


<210> 20938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20938
acaaaagaag actttcttgt                                                   20


<210> 20939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20939
cattcgatgc aggacaaaag                                                   20


<210> 20940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20940
aggcattcga tgcaggacaa                                                   20


<210> 20941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20941
tctcaacagg cattcgatgc                                                   20


<210> 20942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20942
gtctcaacag gcattcgatg                                                   20


<210> 20943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20943
gactctgttt gtgtctcaac                                                   20


<210> 20944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20944
tgactctgtt tgtgtctcaa                                                   20


<210> 20945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20945
atgaagatgt caggttaaag                                                   20


<210> 20946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20946
ccatgaagat gtcaggttaa                                                   20


<210> 20947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20947
gccatgaaga tgtcaggtta                                                   20


<210> 20948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20948
aactttgcca tgaagatgtc                                                   20


<210> 20949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20949
caactttgcc atgaagatgt                                                   20


<210> 20950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20950
aatgatccaa ctttgccatg                                                   20


<210> 20951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20951
atatgagatt ggccaataag                                                   20


<210> 20952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20952
tatatgagat tggccaataa                                                   20


<210> 20953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20953
tatatatgag attggccaat                                                   20


<210> 20954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20954
catatgacta tatatgagat                                                   20


<210> 20955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20955
agtgacatat gactatatat                                                   20


<210> 20956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20956
cagaacatat ctctatctgt                                                   20


<210> 20957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20957
tcacctaatg atgtatttgt                                                   20


<210> 20958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20958
aatacaatgt aggatattca                                                   20


<210> 20959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20959
tgtttgtgta aatacaatgt                                                   20


<210> 20960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20960
ttgtttgtgt aaatacaatg                                                   20


<210> 20961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20961
cctagatgta tagaaggcta                                                   20


<210> 20962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20962
atttagccta gatgtataga                                                   20


<210> 20963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20963
tatttagcct agatgtatag                                                   20


<210> 20964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20964
cactatttag cctagatgta                                                   20


<210> 20965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20965
ataggccaca ctatttagcc                                                   20


<210> 20966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20966
gagcaatagg ccacactatt                                                   20


<210> 20967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20967
atttgtagcc taggagcaat                                                   20


<210> 20968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20968
gatttgtagc ctaggagcaa                                                   20


<210> 20969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20969
tgtacagatt tgtagcctag                                                   20


<210> 20970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20970
gctgtacaga tttgtagcct                                                   20


<210> 20971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20971
tgctgtacag atttgtagcc                                                   20


<210> 20972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20972
taacatgctg tacagatttg                                                   20


<210> 20973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20973
ttcagcaata acatgctgta                                                   20


<210> 20974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20974
ctgtttatac ttacagtatt                                                   20


<210> 20975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20975
ttattaactg tttatactta                                                   20


<210> 20976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20976
tgcttagtcc tcatggttgg                                                   20


<210> 20977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20977
atttgcttag tcctcatggt                                                   20


<210> 20978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20978
tatcatttgc ttagtcctca                                                   20


<210> 20979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20979
gactactagt atcatttgct                                                   20


<210> 20980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20980
taacaataaa tagtgactac                                                   20


<210> 20981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20981
gtctgacaga taacaataaa                                                   20


<210> 20982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20982
acatttttat acatgtctga                                                   20


<210> 20983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20983
gagggttaaa tgaaataaca                                                   20


<210> 20984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 20984
aaggtttcta aatagctgga                                                   20


<210> 20985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20985
aaaggtttct aaatagctgg                                                   20


<210> 20986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20986
aaaaggtttc taaatagctg                                                   20


<210> 20987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20987
taaaaaggtt tctaaatagc                                                   20


<210> 20988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20988
cttgtaaaaa ggtttctaaa                                                   20


<210> 20989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20989
ccttatctcc ccttgtaaaa                                                   20


<210> 20990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20990
tccttatctc cccttgtaaa                                                   20


<210> 20991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20991
gcaagtcctt taaattatcc                                                   20


<210> 20992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 20992
ccacctgagt cacatttagc                                                   20


<210> 20993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20993
gttaccacct gagtcacatt                                                   20


<210> 20994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 20994
aactgtgcca gttaccacct                                                   20


<210> 20995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 20995
tattttagtc ccaactgtgc                                                   20


<210> 20996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20996
tttagtatgg acctatattt                                                   20


<210> 20997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 20997
ttaggccctt ctgtttagta                                                   20


<210> 20998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 20998
actctttagg cccttctgtt                                                   20


<210> 20999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 20999
tagtgaaaga ttgactcttt                                                   20


<210> 21000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21000
ctagtgaaag attgactctt                                                   20


<210> 21001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21001
ttaaattacc aggctagtga                                                   20


<210> 21002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21002
ttctagttaa attaccaggc                                                   20


<210> 21003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21003
ttcattctag ttaaattacc                                                   20


<210> 21004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21004
attcattcta gttaaattac                                                   20


<210> 21005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21005
attctgacct tgattcattc                                                   20


<210> 21006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21006
tcctgagatt atcatgtgtc                                                   20


<210> 21007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21007
accctccttt ctctgttcct                                                   20


<210> 21008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21008
atttatgcct ctcttgtgat                                                   20


<210> 21009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21009
catttatgcc tctcttgtga                                                   20


<210> 21010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21010
tctagaaaat gcctcactga                                                   20


<210> 21011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21011
ctctagaaaa tgcctcactg                                                   20


<210> 21012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21012
ctgggagtgc attagcactc                                                   20


<210> 21013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21013
agggctcgct gggagtgcat                                                   20


<210> 21014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21014
catcctgcag ggctcgctgg                                                   20


<210> 21015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21015
ggcatcctgc agggctcgct                                                   20


<210> 21016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21016
aggcatcctg cagggctcgc                                                   20


<210> 21017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21017
aaagtcaaag gcatcctgca                                                   20


<210> 21018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21018
taaagtcaaa ggcatcctgc                                                   20


<210> 21019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21019
ttaaagtcaa aggcatcctg                                                   20


<210> 21020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21020
aaacagagcc ttaaagtcaa                                                   20


<210> 21021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21021
aaaacagagc cttaaagtca                                                   20


<210> 21022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21022
atcaccaaaa cagagcctta                                                   20


<210> 21023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21023
caaatggaat caccaaaaca                                                   20


<210> 21024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21024
ggcaaatgga atcaccaaaa                                                   20


<210> 21025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21025
gagtaggtct ccagggcaaa                                                   20


<210> 21026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21026
aggtagagag taggtctcca                                                   20


<210> 21027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21027
aaggtagaga gtaggtctcc                                                   20


<210> 21028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21028
gaaggtagag agtaggtctc                                                   20


<210> 21029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21029
cagtggagaa ggtagagagt                                                   20


<210> 21030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21030
acagtggaga aggtagagag                                                   20


<210> 21031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21031
gagacagtgg agaaggtaga                                                   20


<210> 21032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21032
cagagacagt ggagaaggta                                                   20


<210> 21033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21033
aacagagaca gtggagaagg                                                   20


<210> 21034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21034
aggaacagag acagtggaga                                                   20


<210> 21035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21035
caggaacaga gacagtggag                                                   20


<210> 21036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21036
ccccaggaac agagacagtg                                                   20


<210> 21037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21037
ctccccagga acagagacag                                                   20


<210> 21038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21038
tccctcccca ggaacagaga                                                   20


<210> 21039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21039
ggtctccctc cccaggaaca                                                   20


<210> 21040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21040
caggtctccc tccccaggaa                                                   20


<210> 21041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21041
ttgtacaggt ctccctcccc                                                   20


<210> 21042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21042
tttgtacagg tctccctccc                                                   20


<210> 21043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21043
aaggataaca cattttgtac                                                   20


<210> 21044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21044
taaggataac acattttgta                                                   20


<210> 21045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21045
ctggccagaa ccagagggta                                                   20


<210> 21046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21046
cctggccaga accagagggt                                                   20


<210> 21047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21047
caaacctggc cagaaccaga                                                   20


<210> 21048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21048
ccaaacctgg ccagaaccag                                                   20


<210> 21049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21049
accaaacctg gccagaacca                                                   20


<210> 21050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21050
taaccaaacc tggccagaac                                                   20


<210> 21051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21051
tcccattaac caaacctggc                                                   20


<210> 21052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21052
tgtctcccat taaccaaacc                                                   20


<210> 21053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21053
cacaggagag aagaagccag                                                   20


<210> 21054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21054
gcacaggaga gaagaagcca                                                   20


<210> 21055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21055
agcacaggag agaagaagcc                                                   20


<210> 21056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21056
tagcacagga gagaagaagc                                                   20


<210> 21057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21057
gccatagcac aggagagaag                                                   20


<210> 21058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21058
tcagccatag cacaggagag                                                   20


<210> 21059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21059
tactcagcca tagcacagga                                                   20


<210> 21060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21060
gctactcagc catagcacag                                                   20


<210> 21061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21061
ctgctactca gccatagcac                                                   20


<210> 21062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21062
tctgctactc agccatagca                                                   20


<210> 21063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21063
acagctctgc tactcagcca                                                   20


<210> 21064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21064
aggatcacag ctctgctact                                                   20


<210> 21065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21065
gtgatcttag tagaggatca                                                   20


<210> 21066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21066
agaacttgtg atcttagtag                                                   20


<210> 21067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21067
cagaacttgt gatcttagta                                                   20


<210> 21068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21068
ggcagaactt gtgatcttag                                                   20


<210> 21069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21069
cctggcagaa cttgtgatct                                                   20


<210> 21070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21070
gtgtcagaga ggctgcctgg                                                   20


<210> 21071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21071
catgtgtcag agaggctgcc                                                   20


<210> 21072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21072
gctgccctca tgtgtcagag                                                   20


<210> 21073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21073
agctgccctc atgtgtcaga                                                   20


<210> 21074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21074
gcagctgccc tcatgtgtca                                                   20


<210> 21075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21075
cagcagctgc cctcatgtgt                                                   20


<210> 21076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21076
ccagaattag actacagcag                                                   20


<210> 21077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21077
ggaccagaat tagactacag                                                   20


<210> 21078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21078
aaaggaccag aattagacta                                                   20


<210> 21079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21079
atgaaggaaa ggaccagaat                                                   20


<210> 21080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21080
gaagggatga aggaaaggac                                                   20


<210> 21081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21081
aggctgaagg gatgaaggaa                                                   20


<210> 21082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21082
taggctgaag ggatgaagga                                                   20


<210> 21083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21083
tgcctaggct gaagggatga                                                   20


<210> 21084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21084
atgcctaggc tgaagggatg                                                   20


<210> 21085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21085
tgttacatgc ctaggctgaa                                                   20


<210> 21086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21086
ctgttacatg cctaggctga                                                   20


<210> 21087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21087
gctgttacat gcctaggctg                                                   20


<210> 21088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21088
ggggaagctg ttacatgcct                                                   20


<210> 21089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21089
gggggaagct gttacatgcc                                                   20


<210> 21090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21090
tagaaactag taacaggggg                                                   20


<210> 21091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21091
acctagaaac tagtaacagg                                                   20


<210> 21092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21092
cacctagaaa ctagtaacag                                                   20


<210> 21093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21093
gcacctagaa actagtaaca                                                   20


<210> 21094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21094
ggcacctaga aactagtaac                                                   20


<210> 21095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21095
aggcacctag aaactagtaa                                                   20


<210> 21096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21096
acagtgaggc acctagaaac                                                   20


<210> 21097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21097
ataagggaca gtgaggcacc                                                   20


<210> 21098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21098
ggaatgaata agggacagtg                                                   20


<210> 21099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21099
gggaatgaat aagggacagt                                                   20


<210> 21100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21100
cttagggaat gaataaggga                                                   20


<210> 21101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21101
tgggcttagg gaatgaataa                                                   20


<210> 21102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21102
ctgggcttag ggaatgaata                                                   20


<210> 21103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21103
gctgggctta gggaatgaat                                                   20


<210> 21104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21104
agaggtgtgg gctgggctta                                                   20


<210> 21105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21105
cagaggtgtg ggctgggctt                                                   20


<210> 21106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21106
acagaggtgt gggctgggct                                                   20


<210> 21107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21107
tatttacaga ggtgtgggct                                                   20


<210> 21108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21108
gtatttacag aggtgtgggc                                                   20


<210> 21109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21109
taaagtattt acagaggtgt                                                   20


<210> 21110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21110
gtaaagtatt tacagaggtg                                                   20


<210> 21111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21111
gtttagtaaa gtatttacag                                                   20


<210> 21112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21112
agtttagtaa agtatttaca                                                   20


<210> 21113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21113
agagtttagt aaagtattta                                                   20


<210> 21114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21114
ctaatagaga gagtttagta                                                   20


<210> 21115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21115
atgggctaat agagagagtt                                                   20


<210> 21116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21116
ctccgatggg ctaatagaga                                                   20


<210> 21117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21117
cactccgatg ggctaataga                                                   20


<210> 21118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21118
accactccga tgggctaata                                                   20


<210> 21119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21119
ggaccactcc gatgggctaa                                                   20


<210> 21120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21120
aacagatgga ccactccgat                                                   20


<210> 21121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21121
aaacagatgg accactccga                                                   20


<210> 21122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21122
gggtcccagc aagaaacaga                                                   20


<210> 21123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21123
ttcagggtcc cagcaagaaa                                                   20


<210> 21124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21124
atgtgattca gggtcccagc                                                   20


<210> 21125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21125
tgtcatgtga ttcagggtcc                                                   20


<210> 21126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21126
actcaatgtc atgtgattca                                                   20


<210> 21127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21127
gactcaatgt catgtgattc                                                   20


<210> 21128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21128
tgactcaatg tcatgtgatt                                                   20


<210> 21129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21129
gtcttagagt tgccttagct                                                   20


<210> 21130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21130
gataagtctt agagttgcct                                                   20


<210> 21131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21131
actgatacag ataagtctta                                                   20


<210> 21132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21132
ccactgatac agataagtct                                                   20


<210> 21133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21133
atggttccac tgatacagat                                                   20


<210> 21134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21134
aataaatggt tccactgata                                                   20


<210> 21135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21135
attgtaaaga gaccaataaa                                                   20


<210> 21136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21136
attgcagaca gaattgtaaa                                                   20


<210> 21137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21137
caattgcaga cagaattgta                                                   20


<210> 21138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21138
ggatacagcg caattgcaga                                                   20


<210> 21139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21139
ccagggatac agcgcaattg                                                   20


<210> 21140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21140
tctctggcta gccagggata                                                   20


<210> 21141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21141
ttgccctctc tggctagcca                                                   20


<210> 21142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21142
tttgccctct ctggctagcc                                                   20


<210> 21143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21143
atttgccctc tctggctagc                                                   20


<210> 21144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21144
tttcatttgc cctctctggc                                                   20


<210> 21145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21145
tgtttttcat ttgccctctc                                                   20


<210> 21146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21146
agtttcagca atgatgtttc                                                   20


<210> 21147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21147
tgagctctcc cctccagttt                                                   20


<210> 21148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21148
ttaatgtgag ctctcccctc                                                   20


<210> 21149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21149
tgggagctgt gagttaatgt                                                   20


<210> 21150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21150
ctcattggat tgggagctgt                                                   20


<210> 21151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21151
gggattcctc attggattgg                                                   20


<210> 21152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21152
cagggattcc tcattggatt                                                   20


<210> 21153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21153
tcagggattc ctcattggat                                                   20


<210> 21154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21154
gcaagtcagg gattcctcat                                                   20


<210> 21155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21155
cagagtgtaa tggcaagtca                                                   20


<210> 21156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21156
gcagagtgta atggcaagtc                                                   20


<210> 21157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21157
cgcagagtgt aatggcaagt                                                   20


<210> 21158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21158
taatcgcaga gtgtaatggc                                                   20


<210> 21159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21159
agaataatcg cagagtgtaa                                                   20


<210> 21160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21160
tctttaatag aataatcgca                                                   20


<210> 21161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21161
actctttaat agaataatcg                                                   20


<210> 21162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21162
aactggccag cactctttaa                                                   20


<210> 21163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21163
ggcaacagtg actaactggc                                                   20


<210> 21164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21164
attaggcaac agtgactaac                                                   20


<210> 21165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21165
aaaatgagca aattaggcaa                                                   20


<210> 21166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21166
tttgccaaaa tgagcaaatt                                                   20


<210> 21167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21167
atttgccaaa atgagcaaat                                                   20


<210> 21168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21168
aagaaataat ttgccaaaat                                                   20


<210> 21169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21169
attccttgct ttactcacag                                                   20


<210> 21170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21170
agtattcctt gctttactca                                                   20


<210> 21171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21171
gacagatctg aatagaagca                                                   20


<210> 21172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21172
cttaggacag atctgaatag                                                   20


<210> 21173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21173
tttcttagga cagatctgaa                                                   20


<210> 21174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21174
attcaggaag tttcttagga                                                   20


<210> 21175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21175
agaaattcag gaagtttctt                                                   20


<210> 21176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21176
gagaaattca ggaagtttct                                                   20


<210> 21177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21177
ggcacccaga gaaattcagg                                                   20


<210> 21178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21178
aatggcaccc agagaaattc                                                   20


<210> 21179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21179
aaatggcacc cagagaaatt                                                   20


<210> 21180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21180
ggctgggcaa atggcaccca                                                   20


<210> 21181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21181
taggctgggc aaatggcacc                                                   20


<210> 21182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21182
actcttctag gctgggcaaa                                                   20


<210> 21183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21183
tatgcaaact cttctaggct                                                   20


<210> 21184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21184
ctatgcaaac tcttctaggc                                                   20


<210> 21185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21185
ggctctatgc aaactcttct                                                   20


<210> 21186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21186
tggctctatg caaactcttc                                                   20


<210> 21187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21187
gacccttctc ttcctgctta                                                   20


<210> 21188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21188
acaggtatga gaaaaactga                                                   20


<210> 21189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21189
gacaggtatg agaaaaactg                                                   20


<210> 21190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21190
ctttcttgtt ggacaggtat                                                   20


<210> 21191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21191
ggcctgcttt cttgttggac                                                   20


<210> 21192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21192
aggcctgctt tcttgttgga                                                   20


<210> 21193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21193
tgataggcct gctttcttgt                                                   20


<210> 21194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21194
aacatcactg cctcagtgat                                                   20


<210> 21195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21195
caacatcact gcctcagtga                                                   20


<210> 21196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21196
cccactcaac atcactgcct                                                   20


<210> 21197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21197
tttgacccca tatttcttat                                                   20


<210> 21198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21198
tttcctggtt tattctgcag                                                   20


<210> 21199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21199
aggtttcctg gtttattctg                                                   20


<210> 21200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21200
ctgaggtcaa acaggtttcc                                                   20


<210> 21201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21201
gagttggcct gaggtcaaac                                                   20


<210> 21202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21202
tgagttggcc tgaggtcaaa                                                   20


<210> 21203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21203
agagagattg agttggcctg                                                   20


<210> 21204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21204
gagagagatt gagttggcct                                                   20


<210> 21205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21205
gagagagaga gagattgagt                                                   20


<210> 21206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21206
cccagagaga gagagagatt                                                   20


<210> 21207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21207
atgagaccca gagagagaga                                                   20


<210> 21208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21208
agatgagacc cagagagaga                                                   20


<210> 21209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21209
gaagatgaga cccagagaga                                                   20


<210> 21210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21210
tagaagatga gacccagaga                                                   20


<210> 21211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21211
catagaagat gagacccaga                                                   20


<210> 21212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21212
gacatagaag atgagaccca                                                   20


<210> 21213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21213
cagacataga agatgagacc                                                   20


<210> 21214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21214
tttttacaga catagaagat                                                   20


<210> 21215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21215
ctcctttttt acagacatag                                                   20


<210> 21216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21216
ctactccttt tttacagaca                                                   20


<210> 21217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21217
cccattctac tcctttttta                                                   20


<210> 21218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21218
tcaccaatgg aagggatctt                                                   20


<210> 21219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21219
cctgagtatc accaatggaa                                                   20


<210> 21220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21220
gcctgagtat caccaatgga                                                   20


<210> 21221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21221
agcctgagta tcaccaatgg                                                   20


<210> 21222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21222
agaagcctga gtatcaccaa                                                   20


<210> 21223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21223
agccttgagc caagaagcct                                                   20


<210> 21224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21224
cctagaagcc ttgagccaag                                                   20


<210> 21225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21225
ccacctagaa gccttgagcc                                                   20


<210> 21226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21226
gtcttccacc tagaagcctt                                                   20


<210> 21227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21227
tcaggctgtc ttccacctag                                                   20


<210> 21228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21228
ccctcaggct gtcttccacc                                                   20


<210> 21229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21229
tgaatgcttc agactccctc                                                   20


<210> 21230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21230
gtgaatgctt cagactccct                                                   20


<210> 21231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21231
cggtgagttt gtgaatgctt                                                   20


<210> 21232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21232
ggagctgtcg atgtctcggt                                                   20


<210> 21233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 21233
ccctggagct gtcgatgtct                                                   20


<210> 21234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21234
cactagtgag cttgcccctg                                                   20


<210> 21235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21235
cccactagtg agcttgcccc                                                   20


<210> 21236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21236
accaaccgcc gcccactagt                                                   20


<210> 21237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21237
gaacaccaac cgccgcccac                                                   20


<210> 21238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21238
ccctgactcc aggcatggag                                                   20


<210> 21239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21239
caaccctgac tccaggcatg                                                   20


<210> 21240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21240
agcaaccctg actccaggca                                                   20


<210> 21241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21241
aacccagcaa ccctgactcc                                                   20


<210> 21242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21242
caacccagca accctgactc                                                   20


<210> 21243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21243
agaagccctc ttcctcaacc                                                   20


<210> 21244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21244
cagcaaggcc ccctccctag                                                   20


<210> 21245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21245
ggccagcaag gccccctccc                                                   20


<210> 21246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21246
ggtgggggtg ctggccagca                                                   20


<210> 21247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21247
gggtgggggt gctggccagc                                                   20


<210> 21248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21248
tgctgggtgg gggtgctggc                                                   20


<210> 21249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21249
ctgctgctgg gtgggggtgc                                                   20


<210> 21250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21250
ggctctctgc tgctgggtgg                                                   20


<210> 21251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21251
gggctctctg ctgctgggtg                                                   20


<210> 21252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21252
ggggctctct gctgctgggt                                                   20


<210> 21253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21253
cggggctctc tgctgctggg                                                   20


<210> 21254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21254
catcggggct ctctgctgct                                                   20


<210> 21255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21255
ccatcggggc tctctgctgc                                                   20


<210> 21256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21256
ggagaccacg aaagccatcg                                                   20


<210> 21257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21257
tggagaccac gaaagccatc                                                   20


<210> 21258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 21258
ctggagacca cgaaagccat                                                   20


<210> 21259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21259
gtctttcctg gagaccacga                                                   20


<210> 21260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21260
agatgatgga gtctttcctg                                                   20


<210> 21261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21261
acagatgatg gagtctttcc                                                   20


<210> 21262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21262
tgagggagtc acagatgatg                                                   20


<210> 21263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21263
cctgagggag tcacagatga                                                   20


<210> 21264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21264
ctcactccct gagggagtca                                                   20


<210> 21265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21265
agatatctca ctccctgagg                                                   20


<210> 21266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21266
cgagatatct cactccctga                                                   20


<210> 21267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21267
ccgagatatc tcactccctg                                                   20


<210> 21268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21268
gccgagatat ctcactccct                                                   20


<210> 21269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21269
ccatttccgg tcccctggcc                                                   20


<210> 21270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21270
gtgttccatt tccggtcccc                                                   20


<210> 21271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 21271
atggcagtgt gttccatttc                                                   20


<210> 21272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21272
aaacgccggg ctagtcatgg                                                   20


<210> 21273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21273
ggaaaacgcc gggctagtca                                                   20


<210> 21274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21274
gcctctggaa aacgccgggc                                                   20


<210> 21275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21275
cctcgcctct ggaaaacgcc                                                   20


<210> 21276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 21276
gcctcgcctc tggaaaacgc                                                   20


<210> 21277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21277
tcttttctag gcctcgcctc                                                   20


<210> 21278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21278
ggcaatgccc agtcttttct                                                   20


<210> 21279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21279
gggcaatgcc cagtcttttc                                                   20


<210> 21280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21280
tgctcctttg gggcaatgcc                                                   20


<210> 21281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21281
ccagccttct tgctcctttg                                                   20


<210> 21282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21282
tccagccttc ttgctccttt                                                   20


<210> 21283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21283
ttccagcctt cttgctcctt                                                   20


<210> 21284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21284
tttcccagag gaccagtttc                                                   20


<210> 21285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21285
ctctagattt cccagaggac                                                   20


<210> 21286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21286
ttgggctcta gatttcccag                                                   20


<210> 21287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21287
gttgggctct agatttccca                                                   20


<210> 21288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21288
gtgttgggct ctagatttcc                                                   20


<210> 21289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21289
tagagggaag tgttgggctc                                                   20


<210> 21290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21290
agtaggtaga gggaagtgtt                                                   20


<210> 21291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21291
gagtaggtag agggaagtgt                                                   20


<210> 21292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21292
aaatgggagt aggtagaggg                                                   20


<210> 21293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21293
gggaaatggg agtaggtaga                                                   20


<210> 21294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21294
agggaaatgg gagtaggtag                                                   20


<210> 21295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21295
cagggaaatg ggagtaggta                                                   20


<210> 21296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21296
ggcagggaaa tgggagtagg                                                   20


<210> 21297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21297
aggggcaggg aaatgggagt                                                   20


<210> 21298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21298
caggggcagg gaaatgggag                                                   20


<210> 21299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21299
agacaggggc agggaaatgg                                                   20


<210> 21300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21300
aaagacaggg gcagggaaat                                                   20


<210> 21301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21301
taaagacagg ggcagggaaa                                                   20


<210> 21302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21302
aggtcataaa gacaggggca                                                   20


<210> 21303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21303
aaggtcataa agacaggggc                                                   20


<210> 21304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21304
aaaggtcata aagacagggg                                                   20


<210> 21305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21305
ctgaaaggtc ataaagacag                                                   20


<210> 21306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21306
actgaaaggt cataaagaca                                                   20


<210> 21307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21307
gactgaaagg tcataaagac                                                   20


<210> 21308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21308
tgactgaaag gtcataaaga                                                   20


<210> 21309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21309
ttagtgactg aaaggtcata                                                   20


<210> 21310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21310
gcctttactt agtgactgaa                                                   20


<210> 21311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21311
tgcctttact tagtgactga                                                   20


<210> 21312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21312
cttagatttg tgcctttact                                                   20


<210> 21313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21313
tgcataccta gaatacccct                                                   20


<210> 21314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21314
ttttccccac catgcatacc                                                   20


<210> 21315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21315
tctttcccgg agtctatcta                                                   20


<210> 21316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21316
ggtctttccc ggagtctatc                                                   20


<210> 21317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21317
ctctctcctg gtctttcccg                                                   20


<210> 21318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 21318
tcctctctcc tggtctttcc                                                   20


<210> 21319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21319
ctgtaatctc tcctctctcc                                                   20


<210> 21320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21320
ataacctatt tgctgagcat                                                   20


<210> 21321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21321
accatgataa cctatttgct                                                   20


<210> 21322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21322
actgaactat ccaggtgaca                                                   20


<210> 21323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21323
aactgaacta tccaggtgac                                                   20


<210> 21324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21324
ggcaatcaac tgaactatcc                                                   20


<210> 21325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21325
tggcaatcaa ctgaactatc                                                   20


<210> 21326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21326
ctagccctgt ggccaaaggt                                                   20


<210> 21327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21327
ttgtctagcc ctgtggccaa                                                   20


<210> 21328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21328
tttgtctagc cctgtggcca                                                   20


<210> 21329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21329
gacagctttg tctagccctg                                                   20


<210> 21330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21330
gaacttagga cagctttgtc                                                   20


<210> 21331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21331
gtggaaaagt gaacttagga                                                   20


<210> 21332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21332
gcatgtggaa aagtgaactt                                                   20


<210> 21333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21333
tgcatgtgga aaagtgaact                                                   20


<210> 21334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21334
tcacaacttt gcatgtggaa                                                   20


<210> 21335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21335
ttaggtcaca actttgcatg                                                   20


<210> 21336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21336
gtgtgcatag tagcctcctt                                                   20


<210> 21337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21337
ggtgtgcata gtagcctcct                                                   20


<210> 21338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21338
tccagtactg gtgtgcatag                                                   20


<210> 21339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21339
tgttccagta ctggtgtgca                                                   20


<210> 21340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21340
taccaagtat gttccagtac                                                   20


<210> 21341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21341
accacttacc aagtatgttc                                                   20


<210> 21342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21342
tcattcaaca accacttacc                                                   20


<210> 21343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21343
tacctaattt tcagacaatg                                                   20


<210> 21344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21344
gaattgtact acctaatttt                                                   20


<210> 21345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21345
actctcacat tcatacagat                                                   20


<210> 21346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21346
aactctcaca ttcatacaga                                                   20


<210> 21347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21347
cacaaactct cacattcata                                                   20


<210> 21348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21348
tagaaactca ttgcactgta                                                   20


<210> 21349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21349
gttcaagcct cgagggatcc                                                   20


<210> 21350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21350
gttgactgtt caagcctcga                                                   20


<210> 21351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21351
tgttgactgt tcaagcctcg                                                   20


<210> 21352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21352
ttgttgactg ttcaagcctc                                                   20


<210> 21353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21353
ctctccattg ttgactgttc                                                   20


<210> 21354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21354
ttaggctgca acccttcctt                                                   20


<210> 21355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21355
cattattctt ccaggaaatt                                                   20


<210> 21356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21356
acattattct tccaggaaat                                                   20


<210> 21357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21357
aggaatgaca ttattcttcc                                                   20


<210> 21358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21358
gaggaatgac attattcttc                                                   20


<210> 21359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21359
ggaaatgttt attgatttgg                                                   20


<210> 21360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21360
gggaaatgtt tattgatttg                                                   20


<210> 21361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21361
atgggaaatg tttattgatt                                                   20


<210> 21362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21362
cctcaatgga agattttgat                                                   20


<210> 21363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21363
ccctcaatgg aagattttga                                                   20


<210> 21364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21364
ccacacagtt ccctcaatgg                                                   20


<210> 21365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21365
aagccacaca gttccctcaa                                                   20


<210> 21366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21366
tctggcaact ttaagccaca                                                   20


<210> 21367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21367
ctcttttctc tggcaacttt                                                   20


<210> 21368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21368
tatgaattag ctcttttctc                                                   20


<210> 21369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21369
agggctctgg gtttatgaat                                                   20


<210> 21370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21370
actaattctc tgagggctct                                                   20


<210> 21371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21371
cactaattct ctgagggctc                                                   20


<210> 21372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21372
ccagcacact aattctctga                                                   20


<210> 21373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21373
cccagcacac taattctctg                                                   20


<210> 21374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21374
acccagcaca ctaattctct                                                   20


<210> 21375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21375
gtcatgggaa ctacctaacc                                                   20


<210> 21376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21376
tcaagtttca ctatggtcat                                                   20


<210> 21377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21377
gtcaagtttc actatggtca                                                   20


<210> 21378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21378
attatggtca agtttcacta                                                   20


<210> 21379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21379
aatgatggtt tattatggtc                                                   20


<210> 21380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21380
acacaaatga tggtttatta                                                   20


<210> 21381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21381
ccacctgagg acacaaatga                                                   20


<210> 21382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21382
tacatactat agaccacctg                                                   20


<210> 21383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21383
gtacatacta tagaccacct                                                   20


<210> 21384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21384
tttagatttt gtacatacta                                                   20


<210> 21385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21385
tttggtatga agtcaatgtt                                                   20


<210> 21386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21386
tatgatcaga gtttggtatg                                                   20


<210> 21387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21387
aaatcggtat gatcagagtt                                                   20


<210> 21388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21388
ggaataaatc ggtatgatca                                                   20


<210> 21389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21389
gtggaataaa tcggtatgat                                                   20


<210> 21390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 21390
ggaaggtgag tggaataaat                                                   20


<210> 21391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21391
aaggagttaa ggaaggtgag                                                   20


<210> 21392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21392
aaaaaggagt taaggaaggt                                                   20


<210> 21393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21393
taataaaaag gagttaagga                                                   20


<210> 21394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21394
gtaataaaaa ggagttaagg                                                   20


<210> 21395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21395
ttagtaataa aaaggagtta                                                   20


<210> 21396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21396
cttagtaata aaaaggagtt                                                   20


<210> 21397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21397
agtagcttag taataaaaag                                                   20


<210> 21398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21398
ttagtagctt agtaataaaa                                                   20


<210> 21399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21399
tttagtagct tagtaataaa                                                   20


<210> 21400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21400
gattctccac tttagtagct                                                   20


<210> 21401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21401
ggcaagattc tccactttag                                                   20


<210> 21402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21402
attggcaaga ttctccactt                                                   20


<210> 21403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21403
taaggagaac cccaattggc                                                   20


<210> 21404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21404
ttagtaagga gaaccccaat                                                   20


<210> 21405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21405
gagataaggg gattagtaag                                                   20


<210> 21406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21406
gtgagataag gggattagta                                                   20


<210> 21407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21407
tgtgagataa ggggattagt                                                   20


<210> 21408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21408
gttctgtgag ataaggggat                                                   20


<210> 21409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21409
cttcagttct gtgagataag                                                   20


<210> 21410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21410
acttcagttc tgtgagataa                                                   20


<210> 21411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21411
aacttcagtt ctgtgagata                                                   20


<210> 21412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21412
aaacttcagt tctgtgagat                                                   20


<210> 21413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21413
agaggaaact tcagttctgt                                                   20


<210> 21414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21414
attatcaaga gaggaaactt                                                   20


<210> 21415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21415
aggcttcaaa ttatcaagag                                                   20


<210> 21416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21416
caggcttcaa attatcaaga                                                   20


<210> 21417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21417
atcaggcttc aaattatcaa                                                   20


<210> 21418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21418
ggatcaggct tcaaattatc                                                   20


<210> 21419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21419
aatggttgct aaacaggatc                                                   20


<210> 21420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21420
taatggttgc taaacaggat                                                   20


<210> 21421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21421
tttaataatg gttgctaaac                                                   20


<210> 21422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21422
ttttaataat ggttgctaaa                                                   20


<210> 21423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21423
taatactgag cttttaataa                                                   20


<210> 21424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21424
agtactctat ttataatact                                                   20


<210> 21425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21425
gggcatgtat tacaggcaga                                                   20


<210> 21426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21426
ttgggcatgt attacaggca                                                   20


<210> 21427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21427
ccttgggcat gtattacagg                                                   20


<210> 21428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21428
agtccttggg catgtattac                                                   20


<210> 21429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21429
tagtccttgg gcatgtatta                                                   20


<210> 21430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21430
ttatgagttc tatagtcctt                                                   20


<210> 21431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21431
tttatgagtt ctatagtcct                                                   20


<210> 21432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21432
tttgcatttt atgagttcta                                                   20


<210> 21433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21433
gaaggatttt tgcattttat                                                   20


<210> 21434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21434
catttgcttc aaaaattgga                                                   20


<210> 21435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21435
tcatttgctt caaaaattgg                                                   20


<210> 21436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21436
ttctcatttg cttcaaaaat                                                   20


<210> 21437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21437
tagtattccc ttccttaata                                                   20


<210> 21438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21438
gtgctcaagt gcaaataatg                                                   20


<210> 21439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21439
cattggtttg cttggtgctc                                                   20


<210> 21440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21440
agtttcttca ttggtttgct                                                   20


<210> 21441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21441
tttcttctca gtttcttcat                                                   20


<210> 21442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21442
tgcaaccaaa attttcttct                                                   20


<210> 21443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21443
taaaataact cgtggccaag                                                   20


<210> 21444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21444
tctaaaataa ctcgtggcca                                                   20


<210> 21445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21445
ttctaaaata actcgtggcc                                                   20


<210> 21446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21446
cttaattcta aaataactcg                                                   20


<210> 21447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21447
attctaatgc ttatactcag                                                   20


<210> 21448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21448
gcaattctaa tgcttatact                                                   20


<210> 21449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21449
tcgttagagg atgaatttta                                                   20


<210> 21450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21450
agaccagttg gtctcgttag                                                   20


<210> 21451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21451
cagaccagtt ggtctcgtta                                                   20


<210> 21452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21452
cacagaccag ttggtctcgt                                                   20


<210> 21453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21453
gtggaaaatc acagaccagt                                                   20


<210> 21454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21454
ttttgtggaa aatcacagac                                                   20


<210> 21455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21455
agggtttttg tggaaaatca                                                   20


<210> 21456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21456
gagacccagg agggtttttg                                                   20


<210> 21457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21457
tatatagaag agacccagga                                                   20


<210> 21458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21458
atatatagaa gagacccagg                                                   20


<210> 21459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21459
aatatataga agagacccag                                                   20


<210> 21460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21460
ggaatatata gaagagaccc                                                   20


<210> 21461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21461
aggaatatat agaagagacc                                                   20


<210> 21462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21462
aaatagagga atatatagaa                                                   20


<210> 21463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21463
ttaaatagag gaatatatag                                                   20


<210> 21464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21464
aaattaaata gaggaatata                                                   20


<210> 21465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21465
aaccaataga aattaaatag                                                   20


<210> 21466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21466
taaccaatag aaattaaata                                                   20


<210> 21467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21467
tataaccaat agaaattaaa                                                   20


<210> 21468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21468
taaagccatt ttataaccaa                                                   20


<210> 21469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21469
cctaatgcag tttttatcta                                                   20


<210> 21470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21470
tgtggtaaat agacctaatg                                                   20


<210> 21471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21471
aggtacattc atgtggtaaa                                                   20


<210> 21472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21472
ttttcccagg tacattcatg                                                   20


<210> 21473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21473
catcctctcc ctcttttccc                                                   20


<210> 21474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21474
gcatcctctc cctcttttcc                                                   20


<210> 21475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21475
ttattggagc ccactcagga                                                   20


<210> 21476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21476
tttattggag cccactcagg                                                   20


<210> 21477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21477
tgatttattg gagcccactc                                                   20


<210> 21478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21478
ttgatttatt ggagcccact                                                   20


<210> 21479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21479
taatgctaat tgatttattg                                                   20


<210> 21480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21480
tttaatgcta attgatttat                                                   20


<210> 21481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21481
aagacaggga ggcaccattt                                                   20


<210> 21482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21482
atgtatgtgc aaagacaggg                                                   20


<210> 21483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21483
catgtatgtg caaagacagg                                                   20


<210> 21484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21484
aacatgtatg tgcaaagaca                                                   20


<210> 21485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21485
caacatgtat gtgcaaagac                                                   20


<210> 21486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21486
acaacatgta tgtgcaaaga                                                   20


<210> 21487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21487
aagaacaaca tgtatgtgca                                                   20


<210> 21488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21488
aggagtattt tcctggcaga                                                   20


<210> 21489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21489
ggggaggagt attttcctgg                                                   20


<210> 21490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21490
tttggggagg agtattttcc                                                   20


<210> 21491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21491
acttgagaga gtttggggag                                                   20


<210> 21492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21492
agacttgaga gagtttgggg                                                   20


<210> 21493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21493
aagacttgag agagtttggg                                                   20


<210> 21494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21494
tgaagacttg agagagtttg                                                   20


<210> 21495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21495
ttgaagactt gagagagttt                                                   20


<210> 21496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21496
attgaagact tgagagagtt                                                   20


<210> 21497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21497
tagtaattga agacttgaga                                                   20


<210> 21498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21498
tctagtaatt gaagacttga                                                   20


<210> 21499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21499
cttctagtaa ttgaagactt                                                   20


<210> 21500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21500
aggggttctt ctagtaattg                                                   20


<210> 21501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21501
atagcatgta ggggttcttc                                                   20


<210> 21502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21502
caacaataaa tagcatgtag                                                   20


<210> 21503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21503
tcaacaataa atagcatgta                                                   20


<210> 21504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21504
atcaacaata aatagcatgt                                                   20


<210> 21505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21505
gatcaacaat aaatagcatg                                                   20


<210> 21506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21506
taattgggat caacaataaa                                                   20


<210> 21507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21507
tcctggagga aggcataatt                                                   20


<210> 21508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21508
ttcctggagg aaggcataat                                                   20


<210> 21509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21509
agaaaaggct tcctggagga                                                   20


<210> 21510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21510
cagaaaaggc ttcctggagg                                                   20


<210> 21511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21511
tatcagaaaa ggcttcctgg                                                   20


<210> 21512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21512
gtatcagaaa aggcttcctg                                                   20


<210> 21513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21513
aggtatcaga aaaggcttcc                                                   20


<210> 21514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21514
ggctggatag gtatcagaaa                                                   20


<210> 21515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21515
gggctggata ggtatcagaa                                                   20


<210> 21516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21516
ttatggggct ggataggtat                                                   20


<210> 21517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21517
ccactcttat ggggctggat                                                   20


<210> 21518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21518
tccactctta tggggctgga                                                   20


<210> 21519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21519
aacatccact cttatggggc                                                   20


<210> 21520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21520
aagaaacatc cactcttatg                                                   20


<210> 21521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21521
gaagaaacat ccactcttat                                                   20


<210> 21522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21522
ggaagaaaca tccactctta                                                   20


<210> 21523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21523
tggtgttttg agaatcaggg                                                   20


<210> 21524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21524
acatggtgtt ttgagaatca                                                   20


<210> 21525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21525
tacatggtgt tttgagaatc                                                   20


<210> 21526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21526
atacatggtg ttttgagaat                                                   20


<210> 21527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21527
agacacatac atggtgtttt                                                   20


<210> 21528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21528
gtgtattaga gacacataca                                                   20


<210> 21529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21529
atgtgttaaa tagtgtatta                                                   20


<210> 21530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21530
ctatgtgtta aatagtgtat                                                   20


<210> 21531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21531
aaacacagct atgtgttaaa                                                   20


<210> 21532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21532
ggaggaggca gatataaaca                                                   20


<210> 21533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21533
ttccatttgg gtggaggagg                                                   20


<210> 21534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21534
gatttccatt tgggtggagg                                                   20


<210> 21535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21535
ggatttccat ttgggtggag                                                   20


<210> 21536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21536
aaggatttcc atttgggtgg                                                   20


<210> 21537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21537
taaggatttc catttgggtg                                                   20


<210> 21538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21538
cctaaggatt tccatttggg                                                   20


<210> 21539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21539
ttccctaagg atttccattt                                                   20


<210> 21540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21540
tttccctaag gatttccatt                                                   20


<210> 21541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21541
agaacatgtt cttttcccta                                                   20


<210> 21542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21542
tagaacatgt tcttttccct                                                   20


<210> 21543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21543
gcttggtata aagagatgac                                                   20


<210> 21544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21544
tactaggtgc ttggtataaa                                                   20


<210> 21545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21545
aatactaggt gcttggtata                                                   20


<210> 21546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21546
attcaacaat actaggtgct                                                   20


<210> 21547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21547
cttgttcatt caacaatact                                                   20


<210> 21548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21548
acttgttcat tcaacaatac                                                   20


<210> 21549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21549
ctttcaaagg gaaaaaagag                                                   20


<210> 21550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21550
tactttcaaa gggaaaaaag                                                   20


<210> 21551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21551
ttactttcaa agggaaaaaa                                                   20


<210> 21552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21552
gcttactttc aaagggaaaa                                                   20


<210> 21553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21553
cagtgatgct tactttcaaa                                                   20


<210> 21554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21554
ccagtgatgc ttactttcaa                                                   20


<210> 21555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21555
tccagtgatg cttactttca                                                   20


<210> 21556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21556
ggtatgtgtg cttgtctctc                                                   20


<210> 21557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21557
gcacttggat gtccaataat                                                   20


<210> 21558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21558
gccccacaca gattagcact                                                   20


<210> 21559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21559
tctgtcagcc ccacacagat                                                   20


<210> 21560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21560
cccattctgt cagccccaca                                                   20


<210> 21561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21561
tttaatttcc cccattctgt                                                   20


<210> 21562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21562
aatgtcaatg acactgaatt                                                   20


<210> 21563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21563
aaatgtcaat gacactgaat                                                   20


<210> 21564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21564
aggatgaatc acagcttcca                                                   20


<210> 21565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21565
tcacagaaca ggatgaatca                                                   20


<210> 21566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21566
agttcagaca atcacagaac                                                   20


<210> 21567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21567
cagttcagac aatcacagaa                                                   20


<210> 21568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21568
gggcacagtt cagacaatca                                                   20


<210> 21569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21569
ggcatacatg gggcacagtt                                                   20


<210> 21570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21570
cacctggcat acatggggca                                                   20


<210> 21571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21571
agcagcacct ggcatacatg                                                   20


<210> 21572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21572
gagcagcacc tggcatacat                                                   20


<210> 21573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21573
tgagcagcac ctggcataca                                                   20


<210> 21574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21574
tgcccctttt gagcagcacc                                                   20


<210> 21575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21575
cttgctttgc cccttttgag                                                   20


<210> 21576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21576
tttcttgctt tgcccctttt                                                   20


<210> 21577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21577
ctcatgacac atccacactt                                                   20


<210> 21578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21578
tatgtgtgca tatacaaaca                                                   20


<210> 21579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21579
aataccatct ctccaaccct                                                   20


<210> 21580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21580
cttttcctgt gctaagccga                                                   20


<210> 21581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21581
tcttttcctg tgctaagccg                                                   20


<210> 21582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21582
tcaatctctt ttcctgtgct                                                   20


<210> 21583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21583
tgtggaaaag gggatcaaca                                                   20


<210> 21584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21584
acactaacag tgtggaaaag                                                   20


<210> 21585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21585
cacactaaca gtgtggaaaa                                                   20


<210> 21586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21586
ccacactaac agtgtggaaa                                                   20


<210> 21587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21587
tccacactaa cagtgtggaa                                                   20


<210> 21588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21588
gtggctccac actaacagtg                                                   20


<210> 21589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21589
ggagggtggc tccacactaa                                                   20


<210> 21590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21590
atatctgctg tgtgggaggg                                                   20


<210> 21591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21591
ataatatctg ctgtgtggga                                                   20


<210> 21592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21592
gataatatct gctgtgtggg                                                   20


<210> 21593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21593
agataatatc tgctgtgtgg                                                   20


<210> 21594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21594
acagataata tctgctgtgt                                                   20


<210> 21595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21595
gacagataat atctgctgtg                                                   20


<210> 21596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21596
tgccctttct ataggtctga                                                   20


<210> 21597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21597
cccaaatatg ccctttctat                                                   20


<210> 21598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21598
ccccaaatat gccctttcta                                                   20


<210> 21599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21599
accaccttcc tgccccttga                                                   20


<210> 21600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21600
gcacctcacc tcagaccctg                                                   20


<210> 21601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21601
atggcttcag cacctcacct                                                   20


<210> 21602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21602
atccagcctg ggaatggctt                                                   20


<210> 21603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21603
gacacaatcc agcctgggaa                                                   20


<210> 21604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21604
tctgtgacac aatccagcct                                                   20


<210> 21605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21605
ctctgtgaca caatccagcc                                                   20


<210> 21606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21606
cccatctctg tgacacaatc                                                   20


<210> 21607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21607
gttgttatca gaaaagtttc                                                   20


<210> 21608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21608
gtcacctgtt gttatcagaa                                                   20


<210> 21609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21609
aagctgtcac ctgttgttat                                                   20


<210> 21610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21610
ttcctaaggt cctgcaattc                                                   20


<210> 21611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21611
aatttctgac ctccttccta                                                   20


<210> 21612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21612
taatttctga cctccttcct                                                   20


<210> 21613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21613
cacaatttta tataattatt                                                   20


<210> 21614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21614
tcacaatttt atataattat                                                   20


<210> 21615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21615
gtggttttta tttttttact                                                   20


<210> 21616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21616
ttttttctga tgcgtcgagg                                                   20


<210> 21617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21617
tttttttttc tgatgcgtcg                                                   20


<210> 21618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21618
tttttttttt ctgatgcgtc                                                   20


<210> 21619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21619
ggttccctgt ccgtggtgct                                                   20


<210> 21620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21620
agtgcaaggt tccctgtccg                                                   20


<210> 21621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21621
gtctgcagtt ctagagtgca                                                   20


<210> 21622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21622
ggtctgcagt tctagagtgc                                                   20


<210> 21623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21623
ggctctggtc tgcagttcta                                                   20


<210> 21624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21624
gaggctctgg tctgcagttc                                                   20


<210> 21625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21625
ccttctgagg ctctggtctg                                                   20


<210> 21626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21626
tcagcttcct tctgaggctc                                                   20


<210> 21627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21627
caaaggtcag cttccttctg                                                   20


<210> 21628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21628
tcaaaggtca gcttccttct                                                   20


<210> 21629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21629
tgtctgcgga catcaaaggt                                                   20


<210> 21630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21630
aaggtgtctg cggacatcaa                                                   20


<210> 21631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21631
taaggtgtct gcggacatca                                                   20


<210> 21632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 21632
tgccaatctt aaggtgtctg                                                   20


<210> 21633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21633
tactgaacat gccaatctta                                                   20


<210> 21634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21634
atactgaaca tgccaatctt                                                   20


<210> 21635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21635
cggtttgtag gaaaggtggg                                                   20


<210> 21636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21636
ccccggtttg taggaaaggt                                                   20


<210> 21637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21637
accccggttt gtaggaaagg                                                   20


<210> 21638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21638
agaaccccgg tttgtaggaa                                                   20


<210> 21639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21639
aagaaccccg gtttgtagga                                                   20


<210> 21640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21640
gaggaagaac cccggtttgt                                                   20


<210> 21641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21641
ggaggaagaa ccccggtttg                                                   20


<210> 21642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 21642
ggacactgga ggaagaaccc                                                   20


<210> 21643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21643
caagatgagg acactggagg                                                   20


<210> 21644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21644
ttccaagatg aggacactgg                                                   20


<210> 21645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21645
attccaagat gaggacactg                                                   20


<210> 21646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21646
tgattccaag atgaggacac                                                   20


<210> 21647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21647
tgggtggtga ttccaagatg                                                   20


<210> 21648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21648
atgggtggtg attccaagat                                                   20


<210> 21649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21649
atcaaatggg tggtgattcc                                                   20


<210> 21650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21650
ggattgggca atcaaatggg                                                   20


<210> 21651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21651
tcaggattgg gcaatcaaat                                                   20


<210> 21652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21652
ttcaggattg ggcaatcaaa                                                   20


<210> 21653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21653
gactcccagg tttcaggatt                                                   20


<210> 21654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21654
tgactcccag gtttcaggat                                                   20


<210> 21655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21655
caatttgact cccaggtttc                                                   20


<210> 21656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21656
ccaatttgac tcccaggttt                                                   20


<210> 21657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21657
gggagtccaa tttgactccc                                                   20


<210> 21658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21658
ggggagtcca atttgactcc                                                   20


<210> 21659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21659
actgtggaaa aaggaaaggg                                                   20


<210> 21660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21660
ggactgtgga aaaaggaaag                                                   20


<210> 21661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21661
tggactgtgg aaaaaggaaa                                                   20


<210> 21662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21662
gtggactgtg gaaaaaggaa                                                   20


<210> 21663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21663
tgtggactgt ggaaaaagga                                                   20


<210> 21664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21664
ggattgtgga ctgtggaaaa                                                   20


<210> 21665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21665
gggattgtgg actgtggaaa                                                   20


<210> 21666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21666
aagattggga ttgtggactg                                                   20


<210> 21667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21667
gatcaacaag attgggattg                                                   20


<210> 21668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21668
ggaagtggat caacaagatt                                                   20


<210> 21669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21669
gggaagtgga tcaacaagat                                                   20


<210> 21670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21670
ccttagggaa gtggatcaac                                                   20


<210> 21671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21671
ataaggacac cttagggaag                                                   20


<210> 21672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21672
attataagga caccttaggg                                                   20


<210> 21673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21673
tgaattataa ggacacctta                                                   20


<210> 21674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21674
gtgaattata aggacacctt                                                   20


<210> 21675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21675
ggtgaattat aaggacacct                                                   20


<210> 21676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21676
gggaaaaggg gtgaattata                                                   20


<210> 21677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21677
ggggaaaagg ggtgaattat                                                   20


<210> 21678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21678
taattataga tggggaaaag                                                   20


<210> 21679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21679
gtaattatag atggggaaaa                                                   20


<210> 21680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21680
tgtaattata gatggggaaa                                                   20


<210> 21681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21681
gtgtaattat agatggggaa                                                   20


<210> 21682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21682
ggaaagtgta attatagatg                                                   20


<210> 21683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21683
aggaaagtgt aattatagat                                                   20


<210> 21684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21684
taggaaagtg taattataga                                                   20


<210> 21685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21685
aaactaggaa agtgtaatta                                                   20


<210> 21686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21686
aatggtgtct taaactagga                                                   20


<210> 21687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21687
ccaaaatggt gtcttaaact                                                   20


<210> 21688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21688
tccaaaatgg tgtcttaaac                                                   20


<210> 21689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21689
atccagacac ccctccaaaa                                                   20


<210> 21690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21690
gcatagagcc taaaaggatc                                                   20


<210> 21691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21691
ctggaggcat agagcctaaa                                                   20


<210> 21692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21692
gctggaggca tagagcctaa                                                   20


<210> 21693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21693
gagaaagagc tggaggcata                                                   20


<210> 21694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21694
cagagaaaga gctggaggca                                                   20


<210> 21695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21695
tgtggcagag aaagagctgg                                                   20


<210> 21696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21696
gtgtggcaga gaaagagctg                                                   20


<210> 21697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21697
gtgtgtggca gagaaagagc                                                   20


<210> 21698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21698
agaggtgtgt ggcagagaaa                                                   20


<210> 21699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21699
gaagaggtgt gtggcagaga                                                   20


<210> 21700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21700
gtgggaagag gtgtgtggca                                                   20


<210> 21701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21701
gagtgggaag aggtgtgtgg                                                   20


<210> 21702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21702
ttggagtggg aagaggtgtg                                                   20


<210> 21703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21703
caatgagttg gagtgggaag                                                   20


<210> 21704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21704
acaatgagtt ggagtgggaa                                                   20


<210> 21705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21705
agacaatgag ttggagtggg                                                   20


<210> 21706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21706
cgtagacaat gagttggagt                                                   20


<210> 21707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21707
ccgtagacaa tgagttggag                                                   20


<210> 21708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21708
ctgccgtaga caatgagttg                                                   20


<210> 21709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21709
agctgccgta gacaatgagt                                                   20


<210> 21710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21710
ttgcagctgc cgtagacaat                                                   20


<210> 21711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21711
acccaccatt gcagctgccg                                                   20


<210> 21712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21712
ctaaagatta cccaccattg                                                   20


<210> 21713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21713
aggctcaggt ttgtgctcta                                                   20


<210> 21714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21714
cgcaggatgg taagaggctc                                                   20


<210> 21715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21715
gcgcaggatg gtaagaggct                                                   20


<210> 21716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21716
aaccagcgca ggatggtaag                                                   20


<210> 21717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21717
caaccagcgc aggatggtaa                                                   20


<210> 21718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21718
tacaaccagc gcaggatggt                                                   20


<210> 21719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21719
tccttacaac cagcgcagga                                                   20


<210> 21720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21720
ctgatcctta caaccagcgc                                                   20


<210> 21721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21721
tctgatcctt acaaccagcg                                                   20


<210> 21722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21722
cccgctctga tccttacaac                                                   20


<210> 21723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21723
agtgtcagag ggctccacag                                                   20


<210> 21724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21724
aagagtgtca gagggctcca                                                   20


<210> 21725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21725
ataaagccaa gagtgtcaga                                                   20


<210> 21726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21726
aataaagcca agagtgtcag                                                   20


<210> 21727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21727
gaataaagcc aagagtgtca                                                   20


<210> 21728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21728
tagaataaag ccaagagtgt                                                   20


<210> 21729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21729
aaggcataga ataaagccaa                                                   20


<210> 21730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21730
agaaggcata gaataaagcc                                                   20


<210> 21731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21731
gtgagagaag gcatagaata                                                   20


<210> 21732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21732
aatgccagtg agagaaggca                                                   20


<210> 21733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21733
ccaaaaatgc cagtgagaga                                                   20


<210> 21734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21734
tccaaaaatg ccagtgagag                                                   20


<210> 21735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21735
acctccaaaa atgccagtga                                                   20


<210> 21736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21736
taacctccaa aaatgccagt                                                   20


<210> 21737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21737
cctttaacct ccaaaaatgc                                                   20


<210> 21738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21738
acctctctcc actcccacaa                                                   20


<210> 21739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21739
cgcaggtgct agcagcacta                                                   20


<210> 21740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21740
tcgcaggtgc tagcagcact                                                   20


<210> 21741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21741
ttcgcaggtg ctagcagcac                                                   20


<210> 21742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21742
tctctcttcg caggtgctag                                                   20


<210> 21743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21743
tgttctctct tcgcaggtgc                                                   20


<210> 21744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21744
acctgctgtt ctctcttcgc                                                   20


<210> 21745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21745
cacctgctgt tctctcttcg                                                   20


<210> 21746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21746
taagtccaag caaatactat                                                   20


<210> 21747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21747
gacacattca tgctaagtcc                                                   20


<210> 21748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21748
ctgggggaca cattcatgct                                                   20


<210> 21749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21749
ccctggcacc ccatgtctgg                                                   20


<210> 21750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21750
cccctggcac cccatgtctg                                                   20


<210> 21751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21751
acccctggca ccccatgtct                                                   20


<210> 21752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21752
cacccctggc accccatgtc                                                   20


<210> 21753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21753
tgtttcagat ctctcacccc                                                   20


<210> 21754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21754
acccttcagc ttctctgttt                                                   20


<210> 21755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21755
ccaccctggt cctaaccctt                                                   20


<210> 21756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21756
gcctaatccc accaccaccc                                                   20


<210> 21757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21757
cgaggtgtct gttcctgcca                                                   20


<210> 21758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21758
gaatgagtgg gggtgacccg                                                   20


<210> 21759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21759
tgaatgagtg ggggtgaccc                                                   20


<210> 21760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21760
agtaccccat gaatgagtgg                                                   20


<210> 21761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21761
gagtacccca tgaatgagtg                                                   20


<210> 21762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21762
agagtacccc atgaatgagt                                                   20


<210> 21763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21763
cagagtaccc catgaatgag                                                   20


<210> 21764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21764
caacagagta ccccatgaat                                                   20


<210> 21765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21765
atctgggtgg ggcaccaaca                                                   20


<210> 21766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21766
ggatctgggt ggggcaccaa                                                   20


<210> 21767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21767
tggtgaaagg gatctgggtg                                                   20


<210> 21768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21768
ctggtgaaag ggatctgggt                                                   20


<210> 21769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21769
cctggtgaaa gggatctggg                                                   20


<210> 21770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21770
tgacctggtg aaagggatct                                                   20


<210> 21771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21771
ctgacctggt gaaagggatc                                                   20


<210> 21772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21772
gctgtgctga cctggtgaaa                                                   20


<210> 21773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21773
agctgtgctg acctggtgaa                                                   20


<210> 21774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21774
tagctgtgct gacctggtga                                                   20


<210> 21775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21775
tcgggatagc tgtgctgacc                                                   20


<210> 21776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21776
gccatgcaag cagctcggga                                                   20


<210> 21777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21777
tgctgccatg caagcagctc                                                   20


<210> 21778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 21778
ctgctgccat gcaagcagct                                                   20


<210> 21779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21779
atcagctgct gccatgcaag                                                   20


<210> 21780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21780
gccatcagct gctgccatgc                                                   20


<210> 21781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21781
atgctgcaag tatgagccat                                                   20


<210> 21782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21782
ttgtagaatg ctgcaagtat                                                   20


<210> 21783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21783
ctttttttgt agaatgctgc                                                   20


<210> 21784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21784
gccaaaagag actttttttg                                                   20


<210> 21785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21785
ccagaagcag gcagccaaaa                                                   20


<210> 21786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21786
tcccagaagc aggcagccaa                                                   20


<210> 21787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21787
atacctatcc cagaagcagg                                                   20


<210> 21788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21788
cccataccta tcccagaagc                                                   20


<210> 21789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21789
ccccatacct atcccagaag                                                   20


<210> 21790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21790
cctccccata cctatcccag                                                   20


<210> 21791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21791
taccctcccc atacctatcc                                                   20


<210> 21792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21792
ctaccttgag gcaagggggc                                                   20


<210> 21793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21793
agtcctacct tgaggcaagg                                                   20


<210> 21794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21794
tagtcctacc ttgaggcaag                                                   20


<210> 21795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21795
ttagtcctac cttgaggcaa                                                   20


<210> 21796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21796
gttagtccta ccttgaggca                                                   20


<210> 21797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21797
agttagtcct accttgaggc                                                   20


<210> 21798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21798
ccacagttag tcctaccttg                                                   20


<210> 21799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21799
accacagtta gtcctacctt                                                   20


<210> 21800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21800
ggcatgacct gtaccacagt                                                   20


<210> 21801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21801
ctggggcatg acctgtacca                                                   20


<210> 21802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21802
tgatcccatg gggaactctg                                                   20


<210> 21803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21803
ttgatcccat ggggaactct                                                   20


<210> 21804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21804
cttgatccca tggggaactc                                                   20


<210> 21805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21805
agcttcagct tgatcccatg                                                   20


<210> 21806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21806
cagcttcagc ttgatcccat                                                   20


<210> 21807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21807
ccagcttcag cttgatccca                                                   20


<210> 21808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21808
tctcagctag agaccagctt                                                   20


<210> 21809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21809
gagtgttctc agctagagac                                                   20


<210> 21810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21810
acaaggagtg ttctcagcta                                                   20


<210> 21811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21811
aaacaaggag tgttctcagc                                                   20


<210> 21812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21812
aactaaacaa ggagtgttct                                                   20


<210> 21813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21813
agagggtgga actaaacaag                                                   20


<210> 21814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21814
gcagagggtg gaactaaaca                                                   20


<210> 21815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21815
ggcagagggt ggaactaaac                                                   20


<210> 21816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21816
aaacagaatg gggcagaggg                                                   20


<210> 21817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21817
gcaaaacaga atggggcaga                                                   20


<210> 21818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21818
agcaaaacag aatggggcag                                                   20


<210> 21819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21819
aagcaaaaca gaatggggca                                                   20


<210> 21820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21820
tgaagcaaaa cagaatgggg                                                   20


<210> 21821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21821
gaatgaagca aaacagaatg                                                   20


<210> 21822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21822
cgaatgaagc aaaacagaat                                                   20


<210> 21823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21823
gcgaatgaag caaaacagaa                                                   20


<210> 21824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21824
agaaagcgaa tgaagcaaaa                                                   20


<210> 21825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21825
ctctcaggag aaagcgaatg                                                   20


<210> 21826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21826
gagggagtgc tctcaggaga                                                   20


<210> 21827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21827
tattgaggga gtgctctcag                                                   20


<210> 21828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21828
cctattgagg gagtgctctc                                                   20


<210> 21829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21829
acctattgag ggagtgctct                                                   20


<210> 21830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21830
gtgcaagtga cctattgagg                                                   20


<210> 21831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21831
ttgtgcaagt gacctattga                                                   20


<210> 21832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21832
cttgtgcaag tgacctattg                                                   20


<210> 21833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21833
tcttgtgcaa gtgacctatt                                                   20


<210> 21834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21834
ctaagtgagg attcttgtgc                                                   20


<210> 21835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21835
ctcaaagaag aagctaagtg                                                   20


<210> 21836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21836
tctcaaagaa gaagctaagt                                                   20


<210> 21837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21837
gttttctcaa agaagaagct                                                   20


<210> 21838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21838
atcaggtttt ctcaaagaag                                                   20


<210> 21839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21839
tagatcaggt tttctcaaag                                                   20


<210> 21840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21840
tattagatca ggttttctca                                                   20


<210> 21841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21841
ctcagggacc atattagatc                                                   20


<210> 21842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21842
cctcagggac catattagat                                                   20


<210> 21843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21843
tcttgcctca gggaccatat                                                   20


<210> 21844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21844
ggaggaatca tcttgcctca                                                   20


<210> 21845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21845
aggaggaatc atcttgcctc                                                   20


<210> 21846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21846
taggaggaat catcttgcct                                                   20


<210> 21847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21847
accgtttagg gagctatagg                                                   20


<210> 21848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21848
caccgtttag ggagctatag                                                   20


<210> 21849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21849
ggcaccgttt agggagctat                                                   20


<210> 21850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21850
gggcaccgtt tagggagcta                                                   20


<210> 21851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21851
caattagggc accgtttagg                                                   20


<210> 21852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21852
ttcaattagg gcaccgttta                                                   20


<210> 21853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21853
cttcaattag ggcaccgttt                                                   20


<210> 21854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21854
acttcaatta gggcaccgtt                                                   20


<210> 21855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21855
tggactagcc acttcaatta                                                   20


<210> 21856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21856
ctggactagc cacttcaatt                                                   20


<210> 21857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21857
tctggactag ccacttcaat                                                   20


<210> 21858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21858
tcttggatac tgttctggac                                                   20


<210> 21859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21859
tccattcttg gatactgttc                                                   20


<210> 21860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21860
ggttgcagac tgtccattct                                                   20


<210> 21861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21861
aagctttgtg aagaaggttg                                                   20


<210> 21862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21862
gagtggaagc tttgtgaaga                                                   20


<210> 21863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21863
ggagtggaag ctttgtgaag                                                   20


<210> 21864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21864
tgaggagtgg aagctttgtg                                                   20


<210> 21865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21865
aggaggtttg tgaggagtgg                                                   20


<210> 21866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21866
agcaggaggt ttgtgaggag                                                   20


<210> 21867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21867
aggagcagga ggtttgtgag                                                   20


<210> 21868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21868
gaaggagcag gaggtttgtg                                                   20


<210> 21869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21869
ggaaggagca ggaggtttgt                                                   20


<210> 21870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21870
gatgctccgg aaggagcagg                                                   20


<210> 21871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21871
agatgctccg gaaggagcag                                                   20


<210> 21872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21872
cgagatgctc cggaaggagc                                                   20


<210> 21873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21873
tcgagatgct ccggaaggag                                                   20


<210> 21874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21874
ccctcgagat gctccggaag                                                   20


<210> 21875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21875
ggccctcgag atgctccgga                                                   20


<210> 21876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21876
aggccctcga gatgctccgg                                                   20


<210> 21877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 21877
aggaggccct cgagatgctc                                                   20


<210> 21878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21878
agaagttcca ggaggccctc                                                   20


<210> 21879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21879
aaaggagaag aagttccagg                                                   20


<210> 21880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21880
caaaggagaa gaagttccag                                                   20


<210> 21881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21881
agcaaaggag aagaagttcc                                                   20


<210> 21882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21882
aagcaaagga gaagaagttc                                                   20


<210> 21883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21883
aaattgaagc aaaggagaag                                                   20


<210> 21884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21884
atgaaattga agcaaaggag                                                   20


<210> 21885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21885
ctgatgaaat tgaagcaaag                                                   20


<210> 21886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21886
cactgatgaa attgaagcaa                                                   20


<210> 21887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21887
ccactgatga aattgaagca                                                   20


<210> 21888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21888
ggcaaccact gatgaaattg                                                   20


<210> 21889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21889
ggcgtatgag gagcagaacc                                                   20


<210> 21890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21890
tggcgtatga ggagcagaac                                                   20


<210> 21891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21891
tcaccatggc gtatgaggag                                                   20


<210> 21892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21892
tagtcaccat ggcgtatgag                                                   20


<210> 21893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21893
tgtagtcacc atggcgtatg                                                   20


<210> 21894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21894
ctgtagtcac catggcgtat                                                   20


<210> 21895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21895
gatcttggct gtagtcacca                                                   20


<210> 21896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21896
ggtcaacttg atcttggctg                                                   20


<210> 21897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21897
ctacctggtc aacttgatct                                                   20


<210> 21898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21898
cttcctggga tctttctacc                                                   20


<210> 21899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21899
tttgtgctcg taatcttcct                                                   20


<210> 21900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21900
ttttgtgctc gtaatcttcc                                                   20


<210> 21901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21901
tgcagaccct gaggacttct                                                   20


<210> 21902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21902
ctgcagaccc tgaggacttc                                                   20


<210> 21903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21903
ccttgaacct gcagaccctg                                                   20


<210> 21904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21904
cccttgaacc tgcagaccct                                                   20


<210> 21905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21905
tcttctttcc cttgaacctg                                                   20


<210> 21906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21906
ggtccatgtg ctatgggtac                                                   20


<210> 21907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21907
gggtccatgt gctatgggta                                                   20


<210> 21908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21908
ttcaggggtc catgtgctat                                                   20


<210> 21909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21909
attcaggggt ccatgtgcta                                                   20


<210> 21910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21910
ggaggctgac ttaaattcag                                                   20


<210> 21911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21911
aggaggctga cttaaattca                                                   20


<210> 21912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21912
gaggaggctg acttaaattc                                                   20


<210> 21913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21913
ggaggaggct gacttaaatt                                                   20


<210> 21914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21914
ggctgtgctt ttcctggagg                                                   20


<210> 21915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21915
tggctgtgct tttcctggag                                                   20


<210> 21916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21916
catggctgtg cttttcctgg                                                   20


<210> 21917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21917
gcatggctgt gcttttcctg                                                   20


<210> 21918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21918
ctgcatggct gtgcttttcc                                                   20


<210> 21919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21919
aggctggtgg gtcagctgca                                                   20


<210> 21920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21920
ttggttggag gctggtgggt                                                   20


<210> 21921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21921
agacttggtt ggaggctggt                                                   20


<210> 21922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21922
cagacttggt tggaggctgg                                                   20


<210> 21923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21923
acgcagactt ggttggaggc                                                   20


<210> 21924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21924
ccccacgcag acttggttgg                                                   20


<210> 21925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21925
cccccacgca gacttggttg                                                   20


<210> 21926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21926
ttcccccacg cagacttggt                                                   20


<210> 21927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21927
tgcattcccc cacgcagact                                                   20


<210> 21928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21928
ctgagctgca ttcccccacg                                                   20


<210> 21929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21929
cgcctctacc agcaggtact                                                   20


<210> 21930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21930
ctgggaacgc ctctaccagc                                                   20


<210> 21931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21931
cctgggaacg cctctaccag                                                   20


<210> 21932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21932
attcctggga acgcctctac                                                   20


<210> 21933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21933
cctcatgaca caggattcct                                                   20


<210> 21934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21934
gcctcatgac acaggattcc                                                   20


<210> 21935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21935
actgttccgc ctcatgacac                                                   20


<210> 21936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21936
cactgttccg cctcatgaca                                                   20


<210> 21937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21937
cagctttgat tcctttgctt                                                   20


<210> 21938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21938
ccagctttga ttcctttgct                                                   20


<210> 21939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21939
aacccggatt ttaactacac                                                   20


<210> 21940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 21940
ccttaaaact tctgacaacc                                                   20


<210> 21941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21941
tgctgcagcc actgccctga                                                   20


<210> 21942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21942
gaccttctct gttcttgctg                                                   20


<210> 21943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21943
accttgtctg caataagcag                                                   20


<210> 21944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21944
taccttgtct gcaataagca                                                   20


<210> 21945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21945
ctaccttgtc tgcaataagc                                                   20


<210> 21946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21946
gctaccttgt ctgcaataag                                                   20


<210> 21947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21947
tgggctacct tgtctgcaat                                                   20


<210> 21948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21948
tgtggttgtc tcgcagccct                                                   20


<210> 21949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21949
ctgtggttgt ctcgcagccc                                                   20


<210> 21950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21950
aaaactctgt ggttgtctcg                                                   20


<210> 21951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21951
atctctgaca taaaactctg                                                   20


<210> 21952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21952
ctgctaataa gaggaagact                                                   20


<210> 21953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21953
cctgctaata agaggaagac                                                   20


<210> 21954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21954
atcatcctgc taataagagg                                                   20


<210> 21955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21955
aagatcatcc tgctaataag                                                   20


<210> 21956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21956
caagatcatc ctgctaataa                                                   20


<210> 21957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21957
tccaagatca tcctgctaat                                                   20


<210> 21958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21958
cctaaacaga ccaagtgtcc                                                   20


<210> 21959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21959
aaccaatacc taaacagacc                                                   20


<210> 21960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21960
aacagaaacc aatacctaaa                                                   20


<210> 21961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21961
cgtccccgtt ttatggataa                                                   20


<210> 21962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21962
gtattagcgt ccccgtttta                                                   20


<210> 21963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21963
aaattctgac gtgaaagtat                                                   20


<210> 21964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21964
tgtatgaaat tctgacgtga                                                   20


<210> 21965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21965
ggcagtcagc tgccttcccc                                                   20


<210> 21966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21966
gggcagtcag ctgccttccc                                                   20


<210> 21967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21967
tagtatcgtg tctgggcagt                                                   20


<210> 21968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21968
cttatagtat cgtgtctggg                                                   20


<210> 21969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21969
gagcttatag tatcgtgtct                                                   20


<210> 21970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21970
agagcttata gtatcgtgtc                                                   20


<210> 21971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21971
atgaactggc aaagagctta                                                   20


<210> 21972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21972
ccctggtatg aactggcaaa                                                   20


<210> 21973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21973
ttccctggta tgaactggca                                                   20


<210> 21974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21974
ctcatttccc tggtatgaac                                                   20


<210> 21975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21975
gctactgact ctcatttccc                                                   20


<210> 21976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21976
tgccaacagg ctcaggtttt                                                   20


<210> 21977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21977
cagatgatgc caacaggctc                                                   20


<210> 21978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21978
gcagatgatg ccaacaggct                                                   20


<210> 21979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21979
actctgcaga tgatgccaac                                                   20


<210> 21980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21980
aactctgcag atgatgccaa                                                   20


<210> 21981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21981
tcccttgata gacaactctg                                                   20


<210> 21982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 21982
taatgtgaga cctcccttga                                                   20


<210> 21983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21983
tcagtgaact tggctaatgt                                                   20


<210> 21984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21984
atataattaa tcagtgaact                                                   20


<210> 21985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21985
cactgttaca tataattaat                                                   20


<210> 21986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21986
gaaagtgctc agtaagtgga                                                   20


<210> 21987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 21987
cacagaaagt gctcagtaag                                                   20


<210> 21988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21988
gaacacagaa agtgctcagt                                                   20


<210> 21989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21989
agaagaacac agaaagtgct                                                   20


<210> 21990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21990
gggagagaga agaacacaga                                                   20


<210> 21991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 21991
taaagggaga gagaagaaca                                                   20


<210> 21992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21992
aagcacttaa agggagagag                                                   20


<210> 21993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21993
gtaaagcact taaagggaga                                                   20


<210> 21994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21994
ttgtaaagca cttaaaggga                                                   20


<210> 21995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 21995
gtttgtaaag cacttaaagg                                                   20


<210> 21996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 21996
gtgtttgtaa agcacttaaa                                                   20


<210> 21997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 21997
agtgtttgta aagcacttaa                                                   20


<210> 21998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21998
tagtgtttgt aaagcactta                                                   20


<210> 21999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 21999
attaaattat agtgtttgta                                                   20


<210> 22000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22000
aacattgagt gattaaatta                                                   20


<210> 22001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22001
atctgtaaag aaagaacatt                                                   20


<210> 22002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22002
agattcctta tctgtaaaga                                                   20


<210> 22003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22003
ccccagattc cttatctgta                                                   20


<210> 22004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22004
actgacttct ttctgacccc                                                   20


<210> 22005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22005
attgacacct gcgtagtttt                                                   20


<210> 22006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22006
tattgacacc tgcgtagttt                                                   20


<210> 22007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22007
taaatatatt gacacctgcg                                                   20


<210> 22008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22008
tcaagtattg ggctacttga                                                   20


<210> 22009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22009
gctaggctga ctcaagtatt                                                   20


<210> 22010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22010
ggctaggctg actcaagtat                                                   20


<210> 22011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22011
ggaggaggct aggctgactc                                                   20


<210> 22012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22012
gccatcttca ggaggaggct                                                   20


<210> 22013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22013
ggccatcttc aggaggaggc                                                   20


<210> 22014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22014
cataggccat cttcaggagg                                                   20


<210> 22015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22015
tcataggcca tcttcaggag                                                   20


<210> 22016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22016
cttcataggc catcttcagg                                                   20


<210> 22017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22017
ccttcatagg ccatcttcag                                                   20


<210> 22018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22018
ttccttcata ggccatcttc                                                   20


<210> 22019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22019
cttccttcat aggccatctt                                                   20


<210> 22020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22020
ttaatctggc cttccttcat                                                   20


<210> 22021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22021
tttaatctgg ccttccttca                                                   20


<210> 22022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22022
ccaggcagtc atttttaatc                                                   20


<210> 22023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22023
ccacctcaat actcaccagg                                                   20


<210> 22024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22024
ttcccacctc aatactcacc                                                   20


<210> 22025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22025
attcccacct caatactcac                                                   20


<210> 22026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22026
atgagagaga ggaaggagtt                                                   20


<210> 22027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22027
ctattatgag agagaggaag                                                   20


<210> 22028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22028
tcctattatg agagagagga                                                   20


<210> 22029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22029
ctcctattat gagagagagg                                                   20


<210> 22030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22030
atcctcctat tatgagagag                                                   20


<210> 22031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22031
catcctccta ttatgagaga                                                   20


<210> 22032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22032
ctcatcctcc tattatgaga                                                   20


<210> 22033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22033
gactcatcct cctattatga                                                   20


<210> 22034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22034
tcgactcatc ctcctattat                                                   20


<210> 22035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22035
ctttacgctc cctgagctga                                                   20


<210> 22036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22036
gagagcactt tacgctccct                                                   20


<210> 22037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22037
atctctgcta gggtggatga                                                   20


<210> 22038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22038
ccatctctgc tagggtggat                                                   20


<210> 22039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22039
tcaggccatc tctgctaggg                                                   20


<210> 22040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22040
tgatcaggcc atctctgcta                                                   20


<210> 22041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22041
ttgatcaggc catctctgct                                                   20


<210> 22042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22042
attgatcagg ccatctctgc                                                   20


<210> 22043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22043
gcattgctgt ttcattgatc                                                   20


<210> 22044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22044
ggcattgctg tttcattgat                                                   20


<210> 22045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22045
ataattctgg acttcaaacg                                                   20


<210> 22046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22046
aataattctg gacttcaaac                                                   20


<210> 22047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22047
aaaatttaaa aaaataattc                                                   20


<210> 22048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22048
ggtaaataaa acaggagaaa                                                   20


<210> 22049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22049
aatgcaggta aataaaacag                                                   20


<210> 22050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22050
ggaatgcagg taaataaaac                                                   20


<210> 22051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22051
aggaatgcag gtaaataaaa                                                   20


<210> 22052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22052
catgtattca caaggaatgc                                                   20


<210> 22053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22053
ccatgtattc acaaggaatg                                                   20


<210> 22054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22054
aagaattcca tgtattcaca                                                   20


<210> 22055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22055
aaagaattcc atgtattcac                                                   20


<210> 22056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22056
tggagaaatc ctgggagtaa                                                   20


<210> 22057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22057
agttcatgga gaaatcctgg                                                   20


<210> 22058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22058
ggagttcatg gagaaatcct                                                   20


<210> 22059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22059
tggagttcat ggagaaatcc                                                   20


<210> 22060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22060
cccagaggtt ggagttcatg                                                   20


<210> 22061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22061
gccccagagg ttggagttca                                                   20


<210> 22062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22062
aaggagagcc ccagaggttg                                                   20


<210> 22063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22063
ataaggagag ccccagaggt                                                   20


<210> 22064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22064
tgggataagg agagccccag                                                   20


<210> 22065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22065
ctgggataag gagagcccca                                                   20


<210> 22066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22066
gtctgggata aggagagccc                                                   20


<210> 22067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22067
atggatgtct gggataagga                                                   20


<210> 22068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22068
acatggatgt ctgggataag                                                   20


<210> 22069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22069
tcacatggat gtctgggata                                                   20


<210> 22070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22070
ttcacatgga tgtctgggat                                                   20


<210> 22071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22071
ggttgttcac atggatgtct                                                   20


<210> 22072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22072
gggttgttca catggatgtc                                                   20


<210> 22073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22073
catggtatgg gttgttcaca                                                   20


<210> 22074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22074
agagctctaa tccatggtat                                                   20


<210> 22075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22075
cagagctcta atccatggta                                                   20


<210> 22076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22076
gttgtcagag ctctaatcca                                                   20


<210> 22077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22077
tgattagaat taagttgtca                                                   20


<210> 22078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22078
actgattaga attaagttgt                                                   20


<210> 22079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22079
acttggaact gattagaatt                                                   20


<210> 22080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22080
gagatagact tggaactgat                                                   20


<210> 22081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22081
aatcgaagtg gagatagact                                                   20


<210> 22082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22082
atcttcaatc gaagtggaga                                                   20


<210> 22083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22083
tgcaatcttc aatcgaagtg                                                   20


<210> 22084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22084
cttgcaatct tcaatcgaag                                                   20


<210> 22085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22085
gaacttgcaa tcttcaatcg                                                   20


<210> 22086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22086
aatgtgggtc tacaaagcca                                                   20


<210> 22087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22087
aaatgtgggt ctacaaagcc                                                   20


<210> 22088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22088
taaatgtggg tctacaaagc                                                   20


<210> 22089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22089
tctttaaatg tgggtctaca                                                   20


<210> 22090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22090
aagagcctat ctttaaatgt                                                   20


<210> 22091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22091
caagagccta tctttaaatg                                                   20


<210> 22092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22092
cccttggaag agcaaaccaa                                                   20


<210> 22093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22093
gccccttgga agagcaaacc                                                   20


<210> 22094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22094
ggttgcctag ccccttggaa                                                   20


<210> 22095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22095
tgggttgcct agccccttgg                                                   20


<210> 22096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22096
aaatgggttg cctagcccct                                                   20


<210> 22097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22097
cctacaggaa atgggttgcc                                                   20


<210> 22098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22098
ttaagaaacc tacaggaaat                                                   20


<210> 22099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22099
attaagaaac ctacaggaaa                                                   20


<210> 22100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22100
gagttaatta agaaacctac                                                   20


<210> 22101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22101
agagttaatt aagaaaccta                                                   20


<210> 22102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22102
ggctgccctc agagttaatt                                                   20


<210> 22103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22103
tagaaacaag gctgccctca                                                   20


<210> 22104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22104
catagaaaca aggctgccct                                                   20


<210> 22105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22105
ctacagaaga catagaaaca                                                   20


<210> 22106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22106
tctacagaag acatagaaac                                                   20


<210> 22107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22107
gtggatttct acagaagaca                                                   20


<210> 22108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22108
gctatggtgg atttctacag                                                   20


<210> 22109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22109
gtggctatgg tggatttcta                                                   20


<210> 22110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22110
tttatatgca gtggctatgg                                                   20


<210> 22111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22111
ctgtttatat gcagtggcta                                                   20


<210> 22112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22112
agtgaactgt ttatatgcag                                                   20


<210> 22113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22113
agcagtgaac tgtttatatg                                                   20


<210> 22114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22114
atctcattta atcctcagag                                                   20


<210> 22115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22115
gtgatctcat ttaatcctca                                                   20


<210> 22116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22116
cagtgatctc atttaatcct                                                   20


<210> 22117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22117
cagaagtgca agacactata                                                   20


<210> 22118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22118
tatttactat gcagaagtgc                                                   20


<210> 22119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22119
atacaatatt tactatgcag                                                   20


<210> 22120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22120
tatatacaat atttactatg                                                   20


<210> 22121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22121
acaataggaa ttttcctttg                                                   20


<210> 22122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22122
cttccaaggt taaaaacaat                                                   20


<210> 22123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22123
gcttccaagg ttaaaaacaa                                                   20


<210> 22124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22124
tatcctttca gcagcttcca                                                   20


<210> 22125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22125
ttatcctttc agcagcttcc                                                   20


<210> 22126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22126
attccagttt atcctttcag                                                   20


<210> 22127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22127
attattccag tttatccttt                                                   20


<210> 22128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22128
ttcttccaca tatattattc                                                   20


<210> 22129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22129
agaaaatagt tgataatttt                                                   20


<210> 22130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22130
agaaaatgga taccagaaaa                                                   20


<210> 22131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22131
tcaaggcaga aaatggatac                                                   20


<210> 22132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22132
aggggtctca aggcagaaaa                                                   20


<210> 22133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22133
gaaggtcagg ggtctcaagg                                                   20


<210> 22134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22134
gaggaaggtc aggggtctca                                                   20


<210> 22135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22135
ggaggaaggt caggggtctc                                                   20


<210> 22136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22136
cactgtggga ggaaggtcag                                                   20


<210> 22137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22137
gcactgtggg aggaaggtca                                                   20


<210> 22138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22138
ggcactgtgg gaggaaggtc                                                   20


<210> 22139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22139
tggcactgtg ggaggaaggt                                                   20


<210> 22140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22140
ccaatggcac tgtgggagga                                                   20


<210> 22141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22141
gccaatggca ctgtgggagg                                                   20


<210> 22142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22142
ttggccaatg gcactgtggg                                                   20


<210> 22143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22143
attggccaat ggcactgtgg                                                   20


<210> 22144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22144
acattggcca atggcactgt                                                   20


<210> 22145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22145
cacattggcc aatggcactg                                                   20


<210> 22146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22146
gaaaggccca cattggccaa                                                   20


<210> 22147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22147
tcctgaggaa aggcccacat                                                   20


<210> 22148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22148
gaagccagag tcctgaggaa                                                   20


<210> 22149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22149
agaagccaga gtcctgagga                                                   20


<210> 22150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22150
gcagagaagc cagagtcctg                                                   20


<210> 22151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22151
tgcagagaag ccagagtcct                                                   20


<210> 22152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22152
gtggggctgc agagaagcca                                                   20


<210> 22153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22153
ctgtggggct gcagagaagc                                                   20


<210> 22154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22154
tcctctgtgg ggctgcagag                                                   20


<210> 22155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22155
gggtcctctg tggggctgca                                                   20


<210> 22156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22156
ctgggtcctc tgtggggctg                                                   20


<210> 22157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22157
ctaaacctgg gtcctctgtg                                                   20


<210> 22158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22158
gctaaacctg ggtcctctgt                                                   20


<210> 22159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22159
agctaaacct gggtcctctg                                                   20


<210> 22160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22160
atgccgtgaa agctaaacct                                                   20


<210> 22161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22161
catgccgtga aagctaaacc                                                   20


<210> 22162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22162
cctgccgggg catgccgtga                                                   20


<210> 22163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22163
ggacagagtg aaccctgccg                                                   20


<210> 22164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22164
cggacagagt gaaccctgcc                                                   20


<210> 22165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 22165
acggacagag tgaaccctgc                                                   20


<210> 22166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22166
ccagctcagg ataacggaca                                                   20


<210> 22167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22167
ggccagctca ggataacgga                                                   20


<210> 22168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 22168
gagaggccag ctcaggataa                                                   20


<210> 22169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22169
tggcagagag aggccagctc                                                   20


<210> 22170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22170
atggcagaga gaggccagct                                                   20


<210> 22171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22171
ctgggatggc agagagaggc                                                   20


<210> 22172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22172
caggctggga tggcagagag                                                   20


<210> 22173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22173
ccaggctggg atggcagaga                                                   20


<210> 22174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22174
gaccaggctg ggatggcaga                                                   20


<210> 22175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22175
tggaccaggc tgggatggca                                                   20


<210> 22176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22176
agtggaccag gctgggatgg                                                   20


<210> 22177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22177
gggagtggac caggctggga                                                   20


<210> 22178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22178
gtgggggagt ggaccaggct                                                   20


<210> 22179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22179
agtgggggag tggaccaggc                                                   20


<210> 22180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22180
aggcagtggg ggagtggacc                                                   20


<210> 22181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22181
caggcagtgg gggagtggac                                                   20


<210> 22182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22182
ccagccaggc agtgggggag                                                   20


<210> 22183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22183
gtgccagcca ggcagtgggg                                                   20


<210> 22184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22184
aggtgccagc caggcagtgg                                                   20


<210> 22185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22185
caggtgccag ccaggcagtg                                                   20


<210> 22186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22186
gcaggtgcca gccaggcagt                                                   20


<210> 22187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22187
ggcaggtgcc agccaggcag                                                   20


<210> 22188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22188
ttgggcaggt gccagccagg                                                   20


<210> 22189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22189
ctattgggca ggtgccagcc                                                   20


<210> 22190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22190
gctattgggc aggtgccagc                                                   20


<210> 22191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22191
gcctgctatt gggcaggtgc                                                   20


<210> 22192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22192
ggccaggcct gctattgggc                                                   20


<210> 22193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22193
aggccaggcc tgctattggg                                                   20


<210> 22194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22194
gagaggccag gcctgctatt                                                   20


<210> 22195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22195
tgagaggcca ggcctgctat                                                   20


<210> 22196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22196
gctcagctcc ctgagaggcc                                                   20


<210> 22197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22197
agctcagctc cctgagaggc                                                   20


<210> 22198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22198
ctacagctca gctccctgag                                                   20


<210> 22199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22199
tctacagctc agctccctga                                                   20


<210> 22200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22200
cctctacagc tcagctccct                                                   20


<210> 22201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22201
atctacacac ctctacagct                                                   20


<210> 22202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22202
ggtccatcta cacacctcta                                                   20


<210> 22203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22203
ctttttgtgg taaagttgtt                                                   20


<210> 22204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22204
cctttttgtg gtaaagttgt                                                   20


<210> 22205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22205
ctcaagtcct ttttgtggta                                                   20


<210> 22206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22206
agcagctcaa gtcctttttg                                                   20


<210> 22207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22207
caatggctcc agagcagctc                                                   20


<210> 22208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22208
tcaaggcaat ggctccagag                                                   20


<210> 22209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22209
ttctcaaggc aatggctcca                                                   20


<210> 22210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22210
atttctcaag gcaatggctc                                                   20


<210> 22211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22211
aatggcattt ctcaaggcaa                                                   20


<210> 22212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22212
ctagataatg gcatttctca                                                   20


<210> 22213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22213
tctagataat ggcatttctc                                                   20


<210> 22214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22214
gcatccttct gtctagataa                                                   20


<210> 22215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22215
cccctcagca tccttctgtc                                                   20


<210> 22216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22216
aatgtaaacc aagagcccct                                                   20


<210> 22217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22217
ttgacttaaa tgtaaaccaa                                                   20


<210> 22218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22218
ctttgactta aatgtaaacc                                                   20


<210> 22219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22219
tgagagggtt gttctgacat                                                   20


<210> 22220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22220
tggttctttg gctcatgaga                                                   20


<210> 22221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22221
ttggttcttt ggctcatgag                                                   20


<210> 22222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22222
tttggttctt tggctcatga                                                   20


<210> 22223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22223
catttggttc tttggctcat                                                   20


<210> 22224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22224
gcacttggca tttggttctt                                                   20


<210> 22225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22225
tcacaaatgc acttggcatt                                                   20


<210> 22226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22226
tgttctttca caaatgcact                                                   20


<210> 22227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22227
ttggtcaaca tcaggttcct                                                   20


<210> 22228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22228
aggagcattt ggtcaacatc                                                   20


<210> 22229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22229
caggagcatt tggtcaacat                                                   20


<210> 22230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22230
tggaaacaag caggagcatt                                                   20


<210> 22231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22231
tgaggactgg aaacaagcag                                                   20


<210> 22232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22232
gctgaggact ggaaacaagc                                                   20


<210> 22233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22233
agctgaggac tggaaacaag                                                   20


<210> 22234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22234
tggagctgag gactggaaac                                                   20


<210> 22235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22235
tctcagttgg agctgaggac                                                   20


<210> 22236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22236
aactatctca gttggagctg                                                   20


<210> 22237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22237
aaactatctc agttggagct                                                   20


<210> 22238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22238
taggaaaact atctcagttg                                                   20


<210> 22239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22239
actaggaaaa ctatctcagt                                                   20


<210> 22240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22240
gctcactagg aaaactatct                                                   20


<210> 22241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22241
tccaccttca tcagctcact                                                   20


<210> 22242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22242
ctccaccttc atcagctcac                                                   20


<210> 22243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22243
gcatgaggct ccaccttcat                                                   20


<210> 22244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22244
acctgtgtgg agcctgcatg                                                   20


<210> 22245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22245
gacctgtgtg gagcctgcat                                                   20


<210> 22246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22246
tgcccaggtc gacctgtgtg                                                   20


<210> 22247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22247
gttgcccagg tcgacctgtg                                                   20


<210> 22248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22248
ctgacggctc catgttgccc                                                   20


<210> 22249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22249
gctgacggct ccatgttgcc                                                   20


<210> 22250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 22250
cccagtgcct gagaggctga                                                   20


<210> 22251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22251
caacaccccc agtgcctgag                                                   20


<210> 22252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22252
acaacacccc cagtgcctga                                                   20


<210> 22253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22253
tcacaacacc cccagtgcct                                                   20


<210> 22254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22254
agcagagctc acaacacccc                                                   20


<210> 22255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22255
gctgagagct tggaaaagca                                                   20


<210> 22256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22256
tggctgagag cttggaaaag                                                   20


<210> 22257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22257
ccatggctga gagcttggaa                                                   20


<210> 22258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22258
cacctccatg gctgagagct                                                   20


<210> 22259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22259
tcacccacct ccatggctga                                                   20


<210> 22260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22260
tctcacccac ctccatggct                                                   20


<210> 22261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22261
gcccatctca cccacctcca                                                   20


<210> 22262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22262
ctttaggcaa aagatcaaaa                                                   20


<210> 22263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22263
actttaggca aaagatcaaa                                                   20


<210> 22264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22264
agcagaaaga ctttaggcaa                                                   20


<210> 22265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22265
ggcatgagca gaaagacttt                                                   20


<210> 22266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22266
aggcatgagc agaaagactt                                                   20


<210> 22267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22267
tggaggaagg catgagcaga                                                   20


<210> 22268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22268
ccactggagg aaggcatgag                                                   20


<210> 22269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22269
tggccactgg aggaaggcat                                                   20


<210> 22270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22270
ctgctttggc cactggagga                                                   20


<210> 22271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22271
gctgctttgg ccactggagg                                                   20


<210> 22272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22272
cctgctgctt tggccactgg                                                   20


<210> 22273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22273
gcctgctgct ttggccactg                                                   20


<210> 22274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22274
ctgcctgctg ctttggccac                                                   20


<210> 22275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22275
ctcagctctg cctgctgctt                                                   20


<210> 22276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22276
gctaagggat gaggacccct                                                   20


<210> 22277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22277
tgagacaaag ctaagggatg                                                   20


<210> 22278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22278
gtgagacaaa gctaagggat                                                   20


<210> 22279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22279
agaatgtgag acaaagctaa                                                   20


<210> 22280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22280
cagaatgtga gacaaagcta                                                   20


<210> 22281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22281
acagaatgtg agacaaagct                                                   20


<210> 22282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22282
gcagaacaga atgtgagaca                                                   20


<210> 22283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22283
caggtggcag aacagaatgt                                                   20


<210> 22284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22284
gaccattcca ggtggcagaa                                                   20


<210> 22285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22285
gcgaagacca ttccaggtgg                                                   20


<210> 22286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22286
tcagcgaaga ccattccagg                                                   20


<210> 22287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22287
gtttcagcga agaccattcc                                                   20


<210> 22288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22288
agtttcagcg aagaccattc                                                   20


<210> 22289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22289
aatacgagat agtttcagcg                                                   20


<210> 22290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22290
gggtgaatac gagatagttt                                                   20


<210> 22291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22291
caggctgggt gaatacgaga                                                   20


<210> 22292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22292
tctccaggct gggtgaatac                                                   20


<210> 22293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22293
aggtaggatg tctccaggct                                                   20


<210> 22294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22294
caggtaggat gtctccaggc                                                   20


<210> 22295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22295
agggcaggta ggatgtctcc                                                   20


<210> 22296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22296
aagggcaggt aggatgtctc                                                   20


<210> 22297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22297
gtgagctttc aagggcaggt                                                   20


<210> 22298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22298
ggtgagcttt caagggcagg                                                   20


<210> 22299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22299
tgaggtgagc tttcaagggc                                                   20


<210> 22300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22300
ttgaggtgag ctttcaaggg                                                   20


<210> 22301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22301
tgtttgaggt gagctttcaa                                                   20


<210> 22302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22302
gtgtttgagg tgagctttca                                                   20


<210> 22303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22303
ggtgtttgag gtgagctttc                                                   20


<210> 22304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22304
ctggaggtgg tgtttgaggt                                                   20


<210> 22305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22305
cttcctggag gtggtgtttg                                                   20


<210> 22306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22306
gcttcctgga ggtggtgttt                                                   20


<210> 22307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22307
tagggaaggc ttcctggagg                                                   20


<210> 22308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22308
aagtagggaa ggcttcctgg                                                   20


<210> 22309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22309
aaagtaggga aggcttcctg                                                   20


<210> 22310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22310
agaaagtagg gaaggcttcc                                                   20


<210> 22311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22311
ggcaagagag aaagtaggga                                                   20


<210> 22312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22312
aggcaagaga gaaagtaggg                                                   20


<210> 22313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22313
gtgaggcaag agagaaagta                                                   20


<210> 22314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22314
tgtgaggcaa gagagaaagt                                                   20


<210> 22315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22315
gtgtgaggca agagagaaag                                                   20


<210> 22316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22316
gcggtgtgag gcaagagaga                                                   20


<210> 22317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22317
ggtggcggtg tgaggcaaga                                                   20


<210> 22318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22318
gaggtggcgg tgtgaggcaa                                                   20


<210> 22319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22319
gtgaggtggc ggtgtgaggc                                                   20


<210> 22320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22320
cacagtgagg tggcggtgtg                                                   20


<210> 22321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22321
acacagtgag gtggcggtgt                                                   20


<210> 22322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 22322
gggcaaacac agtgaggtgg                                                   20


<210> 22323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22323
gctgggcaaa cacagtgagg                                                   20


<210> 22324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22324
taggctgggc aaacacagtg                                                   20


<210> 22325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22325
ataggctggg caaacacagt                                                   20


<210> 22326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22326
cttcataggc tgggcaaaca                                                   20


<210> 22327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22327
tactagaggc ttcataggct                                                   20


<210> 22328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22328
ttactagagg cttcataggc                                                   20


<210> 22329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22329
ttctttacta gaggcttcat                                                   20


<210> 22330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22330
gttctttact agaggcttca                                                   20


<210> 22331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22331
gaaaacaagt tctttactag                                                   20


<210> 22332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22332
ggaaaacaag ttctttacta                                                   20


<210> 22333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22333
gtggaaaaca agttctttac                                                   20


<210> 22334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22334
gatgctaccc tgtggaaaac                                                   20


<210> 22335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22335
gacataaaga tgctaccctg                                                   20


<210> 22336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22336
atttctcatt catagacata                                                   20


<210> 22337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22337
agtttgcaat ttctcattca                                                   20


<210> 22338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22338
aaatccagcc tataagctgc                                                   20


<210> 22339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22339
gtgggccaaa tccagcctat                                                   20


<210> 22340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22340
atatttctgt gggccaaatc                                                   20


<210> 22341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22341
gccaaacaaa atatttctgt                                                   20


<210> 22342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22342
ggccaaacaa aatatttctg                                                   20


<210> 22343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22343
aaaaatgtct acatattgtt                                                   20


<210> 22344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22344
aaaaaatgtc tacatattgt                                                   20


<210> 22345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22345
aatctcccaa ccgtaaacat                                                   20


<210> 22346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22346
taaaatagag ataggaaatt                                                   20


<210> 22347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22347
ccaactttta aaatagagat                                                   20


<210> 22348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22348
tccaactttt aaaatagaga                                                   20


<210> 22349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22349
ctcttccaac ttttaaaata                                                   20


<210> 22350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22350
agctcttcca acttttaaaa                                                   20


<210> 22351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22351
aaatgtgggt tcactgtttc                                                   20


<210> 22352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22352
tggttgccat gtggaaatgt                                                   20


<210> 22353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22353
ttggttgcca tgtggaaatg                                                   20


<210> 22354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22354
tccagctttt ggttgccatg                                                   20


<210> 22355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22355
ccactgctcg gtccagcttt                                                   20


<210> 22356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22356
gacagcccca ctgctcggtc                                                   20


<210> 22357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 22357
aaggggacag ccccactgct                                                   20


<210> 22358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22358
catgcctcct ctaaagggga                                                   20


<210> 22359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22359
agttcatgcc tcctctaaag                                                   20


<210> 22360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22360
gagttcatgc ctcctctaaa                                                   20


<210> 22361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22361
agagttcatg cctcctctaa                                                   20


<210> 22362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22362
gagagttcat gcctcctcta                                                   20


<210> 22363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22363
ggagggaacc taggagctga                                                   20


<210> 22364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22364
caggagggaa cctaggagct                                                   20


<210> 22365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22365
tgggccagga gggaacctag                                                   20


<210> 22366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22366
agtgggccag gagggaacct                                                   20


<210> 22367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22367
gagtgggcca ggagggaacc                                                   20


<210> 22368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22368
atgagtggag tgggccagga                                                   20


<210> 22369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22369
aatgagtgga gtgggccagg                                                   20


<210> 22370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22370
aaatgagtgg agtgggccag                                                   20


<210> 22371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22371
acaaatgagt ggagtgggcc                                                   20


<210> 22372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22372
aacaaatgag tggagtgggc                                                   20


<210> 22373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22373
taacaacaaa tgagtggagt                                                   20


<210> 22374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22374
ataacaacaa atgagtggag                                                   20


<210> 22375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22375
ttcataacaa caaatgagtg                                                   20


<210> 22376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22376
gattcataac aacaaatgag                                                   20


<210> 22377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22377
ccagattcat aacaacaaat                                                   20


<210> 22378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22378
tttcgaattc ttacagaggc                                                   20


<210> 22379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22379
gcaatttcga attcttacag                                                   20


<210> 22380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22380
tgcaatttcg aattcttaca                                                   20


<210> 22381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22381
tttgcaattt cgaattctta                                                   20


<210> 22382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22382
agaggaaaaa acacatgtat                                                   20


<210> 22383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22383
cacattaccc tcacaagtag                                                   20


<210> 22384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22384
ccacattacc ctcacaagta                                                   20


<210> 22385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22385
agccacatta ccctcacaag                                                   20


<210> 22386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22386
tatagccaca ttaccctcac                                                   20


<210> 22387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22387
tcacagctaa ctccattcta                                                   20


<210> 22388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22388
tgctctacac ttaatcatca                                                   20


<210> 22389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22389
ataaataatc taccccagga                                                   20


<210> 22390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22390
aataaataat ctaccccagg                                                   20


<210> 22391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22391
tttaataaat aatctacccc                                                   20


<210> 22392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22392
ttttaataaa taatctaccc                                                   20


<210> 22393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22393
atacatagag acaagaatta                                                   20


<210> 22394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22394
gggtgtggat acatagagac                                                   20


<210> 22395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22395
ggaaagggtg tggatacata                                                   20


<210> 22396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22396
ttggaaaggg tgtggataca                                                   20


<210> 22397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22397
aagtcacatt ggaaagggtg                                                   20


<210> 22398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22398
ctgaaaagtc acattggaaa                                                   20


<210> 22399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22399
gctgaaaagt cacattggaa                                                   20


<210> 22400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22400
agctgaaaag tcacattgga                                                   20


<210> 22401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22401
aaagagctga aaagtcacat                                                   20


<210> 22402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22402
actcaatgga aagagctgaa                                                   20


<210> 22403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22403
acttcatcac tcaatggaaa                                                   20


<210> 22404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22404
agacttcatc actcaatgga                                                   20


<210> 22405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22405
aaatagactt catcactcaa                                                   20


<210> 22406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22406
agatccaaga gacagagaaa                                                   20


<210> 22407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22407
cagtagagat ccaagagaca                                                   20


<210> 22408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22408
tccagtagag atccaagaga                                                   20


<210> 22409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22409
gcagtccagt agagatccaa                                                   20


<210> 22410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22410
ttgcagtcca gtagagatcc                                                   20


<210> 22411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22411
aagcaagttg cagtccagta                                                   20


<210> 22412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22412
taaagcaagt tgcagtccag                                                   20


<210> 22413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22413
gactaaagca agttgcagtc                                                   20


<210> 22414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22414
ttcttgacta aagcaagttg                                                   20


<210> 22415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22415
gatacattct tgactaaagc                                                   20


<210> 22416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22416
ttctgataca ttcttgacta                                                   20


<210> 22417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22417
ggcttcttca ggcctaggct                                                   20


<210> 22418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22418
tgcaaggctt cttcaggcct                                                   20


<210> 22419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22419
ttgcaaggct tcttcaggcc                                                   20


<210> 22420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22420
gaagtttgca aggcttcttc                                                   20


<210> 22421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22421
ggaagtttgc aaggcttctt                                                   20


<210> 22422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22422
aaaaacagtg gaagtttgca                                                   20


<210> 22423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22423
gaaaaacagt ggaagtttgc                                                   20


<210> 22424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22424
tgttcccaga aaaacagtgg                                                   20


<210> 22425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22425
cagtgttccc agaaaaacag                                                   20


<210> 22426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22426
tggcagtgtt cccagaaaaa                                                   20


<210> 22427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22427
tgttctcatg gcagtgttcc                                                   20


<210> 22428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22428
gcctgggcct gttctcatgg                                                   20


<210> 22429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22429
ttagcctggg cctgttctca                                                   20


<210> 22430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22430
acccccaaac aggttagcct                                                   20


<210> 22431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22431
cacccccaaa caggttagcc                                                   20


<210> 22432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22432
cctctcaccc ccaaacaggt                                                   20


<210> 22433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22433
gtggcctctc acccccaaac                                                   20


<210> 22434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22434
tgtggcctct cacccccaaa                                                   20


<210> 22435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22435
acgtcctgtc tctgctcatg                                                   20


<210> 22436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22436
aacttggaga tggctggtct                                                   20


<210> 22437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22437
taacttggag atggctggtc                                                   20


<210> 22438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22438
catattaact tggagatggc                                                   20


<210> 22439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22439
acagcatatt aacttggaga                                                   20


<210> 22440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22440
gcagacagca tattaacttg                                                   20


<210> 22441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22441
atgcagacag catattaact                                                   20


<210> 22442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22442
ctcattcatg catatgcaga                                                   20


<210> 22443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22443
taggctcatt catgcatatg                                                   20


<210> 22444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22444
ggcattgggt gacattgact                                                   20


<210> 22445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22445
gggcattggg tgacattgac                                                   20


<210> 22446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22446
actgggatca gatgggcatt                                                   20


<210> 22447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22447
gactgggatc agatgggcat                                                   20


<210> 22448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22448
attttggact gggatcagat                                                   20


<210> 22449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22449
cattttggac tgggatcaga                                                   20


<210> 22450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22450
tcagcatttt ggactgggat                                                   20


<210> 22451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22451
gtgcatcagc attttggact                                                   20


<210> 22452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22452
tgtgcatcag cattttggac                                                   20


<210> 22453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22453
gattctgtgc atcagcattt                                                   20


<210> 22454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22454
taattcatga ttctgtgcat                                                   20


<210> 22455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22455
tggggaggga atgtatgagt                                                   20


<210> 22456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22456
ctcatgggga gggaatgtat                                                   20


<210> 22457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22457
caacccagag ctcatgggga                                                   20


<210> 22458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22458
ccaacccaga gctcatgggg                                                   20


<210> 22459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22459
gccaacccag agctcatggg                                                   20


<210> 22460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22460
ttgccaaccc agagctcatg                                                   20


<210> 22461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22461
tttgccaacc cagagctcat                                                   20


<210> 22462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22462
ctttgccaac ccagagctca                                                   20


<210> 22463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22463
tcatggcctt tgccaaccca                                                   20


<210> 22464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22464
aatcatggcc tttgccaacc                                                   20


<210> 22465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22465
atgtataaat aaataaatca                                                   20


<210> 22466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22466
tggggttgca ggtcctggga                                                   20


<210> 22467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22467
cagatggggt tgcaggtcct                                                   20


<210> 22468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22468
acagatgggg ttgcaggtcc                                                   20


<210> 22469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22469
atgggcacag atggggttgc                                                   20


<210> 22470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22470
tatgggcaca gatggggttg                                                   20


<210> 22471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22471
gcatattatg ggcacagatg                                                   20


<210> 22472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22472
ggcatattat gggcacagat                                                   20


<210> 22473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22473
tggcatatta tgggcacaga                                                   20


<210> 22474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22474
tccttggcat attatgggca                                                   20


<210> 22475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22475
tcttgtcctt ggcatattat                                                   20


<210> 22476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22476
atcttgtcct tggcatatta                                                   20


<210> 22477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22477
ttccttctcc atcttgtcct                                                   20


<210> 22478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22478
cccaacttat gacaaagcac                                                   20


<210> 22479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22479
tgagttccca acttatgaca                                                   20


<210> 22480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22480
caatggatct gactcagggt                                                   20


<210> 22481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22481
gtggcaatgg atctgactca                                                   20


<210> 22482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22482
tgtggcaatg gatctgactc                                                   20


<210> 22483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22483
gtgtggcaat ggatctgact                                                   20


<210> 22484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22484
gaccccttac tgtgtggcaa                                                   20


<210> 22485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22485
acttctgacc ccttactgtg                                                   20


<210> 22486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22486
gatatctaca taaataagcg                                                   20


<210> 22487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22487
agatatctac ataaataagc                                                   20


<210> 22488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22488
cagcagatat ctacataaat                                                   20


<210> 22489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22489
tcttttcttc ctttcttcag                                                   20


<210> 22490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22490
ctttcttttc ttcctttctt                                                   20


<210> 22491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22491
agggttcaga accatctgtg                                                   20


<210> 22492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22492
gagggttcag aaccatctgt                                                   20


<210> 22493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22493
aaggcttggg ttggagggtt                                                   20


<210> 22494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22494
cacacaaggc ttgggttgga                                                   20


<210> 22495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22495
ccacacaagg cttgggttgg                                                   20


<210> 22496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22496
accacacaag gcttgggttg                                                   20


<210> 22497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22497
tcaccacaca aggcttgggt                                                   20


<210> 22498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22498
gcattcacca cacaaggctt                                                   20


<210> 22499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22499
tgcattcacc acacaaggct                                                   20


<210> 22500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22500
aatattgcat tcaccacaca                                                   20


<210> 22501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22501
gaatattgca ttcaccacac                                                   20


<210> 22502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22502
gagctcactt tggaagactt                                                   20


<210> 22503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22503
ggagctcact ttggaagact                                                   20


<210> 22504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22504
gccaaaggag ctcactttgg                                                   20


<210> 22505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22505
gtagccaaag gagctcactt                                                   20


<210> 22506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22506
ctgagtacat gtagccaaag                                                   20


<210> 22507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22507
cactgagtac atgtagccaa                                                   20


<210> 22508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22508
ccactgagta catgtagcca                                                   20


<210> 22509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22509
gcatgcccac tgagtacatg                                                   20


<210> 22510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22510
tgtggcccag catgcccact                                                   20


<210> 22511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22511
tttacaactt ccatgtggcc                                                   20


<210> 22512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22512
gtgactttac aacttccatg                                                   20


<210> 22513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22513
ctgcttagct cttctctttt                                                   20


<210> 22514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22514
tgagagccga agtcactgct                                                   20


<210> 22515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22515
ctgggggaga ttgagagccg                                                   20


<210> 22516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22516
cctctgctgg gggagattga                                                   20


<210> 22517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22517
tacctctgct gggggagatt                                                   20


<210> 22518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22518
tcattctacc tctgctgggg                                                   20


<210> 22519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22519
agtcattcta cctctgctgg                                                   20


<210> 22520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22520
aagtcattct acctctgctg                                                   20


<210> 22521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22521
caagtcattc tacctctgct                                                   20


<210> 22522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22522
gcaagtcatt ctacctctgc                                                   20


<210> 22523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22523
tgagccataa atctagaggc                                                   20


<210> 22524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22524
gaaatgagcc ataaatctag                                                   20


<210> 22525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22525
ggaaatgagc cataaatcta                                                   20


<210> 22526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22526
aaggaaatga gccataaatc                                                   20


<210> 22527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22527
catccctctt gcaaggaaat                                                   20


<210> 22528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22528
tgctcagcat ccctcttgca                                                   20


<210> 22529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22529
ttgctcagca tccctcttgc                                                   20


<210> 22530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22530
gtattctatt tcctgttgct                                                   20


<210> 22531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22531
ttgagttgtg ttttactttt                                                   20


<210> 22532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22532
cttgagttgt gttttacttt                                                   20


<210> 22533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22533
cctgccaaaa tggttctctt                                                   20


<210> 22534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22534
actccccttt cctgccaaaa                                                   20


<210> 22535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22535
ggagcccctg tgtgtgtgta                                                   20


<210> 22536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22536
atatagggac aggggatatg                                                   20


<210> 22537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22537
tcatataggg acaggggata                                                   20


<210> 22538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22538
ttggtatcat atagggacag                                                   20


<210> 22539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22539
cttggtatca tatagggaca                                                   20


<210> 22540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22540
ccttggtatc atatagggac                                                   20


<210> 22541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22541
cccttggtat catataggga                                                   20


<210> 22542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22542
tggacccttg gtatcatata                                                   20


<210> 22543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22543
ttggaccctt ggtatcatat                                                   20


<210> 22544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22544
gttggaccct tggtatcata                                                   20


<210> 22545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22545
ccaaggtctg gttggaccct                                                   20


<210> 22546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22546
catagggacc aaggtctggt                                                   20


<210> 22547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22547
cttccatagg gaccaaggtc                                                   20


<210> 22548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22548
agtctcttcc atagggacca                                                   20


<210> 22549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22549
gagtctcttc catagggacc                                                   20


<210> 22550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22550
tgagtggagt ctcttccata                                                   20


<210> 22551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22551
gtgagtggag tctcttccat                                                   20


<210> 22552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22552
cgtgagtgga gtctcttcca                                                   20


<210> 22553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22553
tctcacagaa aacgtgagtg                                                   20


<210> 22554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22554
catctcacag aaaacgtgag                                                   20


<210> 22555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22555
actcatctca cagaaaacgt                                                   20


<210> 22556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22556
acaaccaact actcatctca                                                   20


<210> 22557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22557
agaatgacat ggctgtcaat                                                   20


<210> 22558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22558
taaatgtgtc aagaatgaca                                                   20


<210> 22559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22559
acctcaaaaa taaatgtgtc                                                   20


<210> 22560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22560
gtggggctgc aactcttcaa                                                   20


<210> 22561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22561
ggtggggctg caactcttca                                                   20


<210> 22562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22562
tggtggggct gcaactcttc                                                   20


<210> 22563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22563
taagtgtttt tgccttggtg                                                   20


<210> 22564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22564
ctaagtgttt ttgccttggt                                                   20


<210> 22565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22565
cctaagtgtt tttgccttgg                                                   20


<210> 22566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22566
ctgcctaagt gtttttgcct                                                   20


<210> 22567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22567
atcctcacca tcttctgcct                                                   20


<210> 22568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22568
gattcactca gtgaagaaac                                                   20


<210> 22569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22569
gggccctgat tcactcagtg                                                   20


<210> 22570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22570
tgtgggggcc ctgattcact                                                   20


<210> 22571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22571
aggcctgaag gtcattgtgg                                                   20


<210> 22572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22572
caggcctgaa ggtcattgtg                                                   20


<210> 22573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22573
gcaggcctga aggtcattgt                                                   20


<210> 22574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22574
cgcaggcctg aaggtcattg                                                   20


<210> 22575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22575
tcatcttccc gcaggcctga                                                   20


<210> 22576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22576
gtcatcttcc cgcaggcctg                                                   20


<210> 22577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22577
taccactgtc atcttcccgc                                                   20


<210> 22578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22578
ataccactgt catcttcccg                                                   20


<210> 22579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22579
tgtgtgctac ctcatccatg                                                   20


<210> 22580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22580
ggaggatggc taagatgaag                                                   20


<210> 22581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22581
gaaggaggat ggctaagatg                                                   20


<210> 22582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22582
agagatgaag gaggatggct                                                   20


<210> 22583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22583
tatgtagaga tgaaggagga                                                   20


<210> 22584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22584
cctgtatgta gagatgaagg                                                   20


<210> 22585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22585
tcctgtatgt agagatgaag                                                   20


<210> 22586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22586
actcctgtat gtagagatga                                                   20


<210> 22587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22587
cactcctgta tgtagagatg                                                   20


<210> 22588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22588
atacttcact cctgtatgta                                                   20


<210> 22589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22589
acatacttca ctcctgtatg                                                   20


<210> 22590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22590
aaggtcttgg aactgccctg                                                   20


<210> 22591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22591
gaaaggtctt ggaactgccc                                                   20


<210> 22592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22592
gcttcggatg agaaaggtct                                                   20


<210> 22593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22593
atgcaagctt cggatgagaa                                                   20


<210> 22594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22594
aatgcaagct tcggatgaga                                                   20


<210> 22595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22595
agtaaatgca agcttcggat                                                   20


<210> 22596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 22596
ctcagagtaa atgcaagctt                                                   20


<210> 22597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22597
ctgcctctca gagtaaatgc                                                   20


<210> 22598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22598
gactctctgc ctgcctctca                                                   20


<210> 22599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22599
ctgactctct gcctgcctct                                                   20


<210> 22600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22600
catcgtcttt ataatgagaa                                                   20


<210> 22601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22601
agttgcatcg tctttataat                                                   20


<210> 22602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22602
aaaatgcatt gcctgggtct                                                   20


<210> 22603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22603
tgataaaaaa tgcattgcct                                                   20


<210> 22604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22604
atgataaaaa atgcattgcc                                                   20


<210> 22605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22605
tcaggaattt tattagcctc                                                   20


<210> 22606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22606
gctagtgtca ggaattttat                                                   20


<210> 22607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22607
taaattgaat tgctagtgtc                                                   20


<210> 22608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22608
ttaaattgaa ttgctagtgt                                                   20


<210> 22609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22609
aattatttaa attgaattgc                                                   20


<210> 22610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22610
gcctggaaaa agtaggtact                                                   20


<210> 22611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22611
gcacagtgcc tggaaaaagt                                                   20


<210> 22612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22612
agcacagtgc ctggaaaaag                                                   20


<210> 22613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22613
cctagcacag tgcctggaaa                                                   20


<210> 22614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22614
ttcatgccta gcacagtgcc                                                   20


<210> 22615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22615
tagtagcttc atgcctagca                                                   20


<210> 22616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22616
gaagttagta gcttcatgcc                                                   20


<210> 22617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22617
aattactggg gtgaagttag                                                   20


<210> 22618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22618
ccaaattact ggggtgaagt                                                   20


<210> 22619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22619
gatgccaaat tactggggtg                                                   20


<210> 22620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22620
agacagatgc caaattactg                                                   20


<210> 22621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22621
aagacagatg ccaaattact                                                   20


<210> 22622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22622
aaagacagat gccaaattac                                                   20


<210> 22623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22623
cccagatgca tgcagaaaga                                                   20


<210> 22624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22624
gcctcccaga tgcatgcaga                                                   20


<210> 22625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22625
agctgcctcc cagatgcatg                                                   20


<210> 22626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22626
ccaagtctca agctgcctcc                                                   20


<210> 22627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22627
gttcatgtgt cccaagtctc                                                   20


<210> 22628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22628
cagtgaggtt catgtgtccc                                                   20


<210> 22629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22629
acacacactc acacacagtg                                                   20


<210> 22630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22630
cacacacact cacacacagt                                                   20


<210> 22631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22631
cacacacaca cactcacaca                                                   20


<210> 22632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22632
ctctttcttt ttctttctct                                                   20


<210> 22633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22633
gactgtctca gtgtttctta                                                   20


<210> 22634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22634
ttatgcccca gtgactgtct                                                   20


<210> 22635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22635
cacaagttct atttatgccc                                                   20


<210> 22636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22636
ctgccagctg tgcttggcac                                                   20


<210> 22637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22637
tctttgctgc cagctgtgct                                                   20


<210> 22638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22638
ggtgtatcct tctttgctgc                                                   20


<210> 22639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22639
tcatccctcc ttaaacaagc                                                   20


<210> 22640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22640
atcatccctc cttaaacaag                                                   20


<210> 22641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22641
caaatcatcc ctccttaaac                                                   20


<210> 22642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22642
gaagttgatt ttacttacca                                                   20


<210> 22643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22643
aagaagttga ttttacttac                                                   20


<210> 22644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22644
gcgaagctgc tctcccaaag                                                   20


<210> 22645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22645
cctgcgaagc tgctctccca                                                   20


<210> 22646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22646
agctctttct gctacctgcg                                                   20


<210> 22647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22647
ctagattgct tccctggtca                                                   20


<210> 22648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22648
tcctagattg cttccctggt                                                   20


<210> 22649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22649
taaatcctag attgcttccc                                                   20


<210> 22650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22650
gactaaccaa aaataaatcc                                                   20


<210> 22651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22651
ctgacacatg tagtgctcag                                                   20


<210> 22652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22652
ggactgacac atgtagtgct                                                   20


<210> 22653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22653
agtccaggga ctgacacatg                                                   20


<210> 22654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22654
atcactcagc tcccagtcca                                                   20


<210> 22655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22655
catcactcag ctcccagtcc                                                   20


<210> 22656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22656
ccatcactca gctcccagtc                                                   20


<210> 22657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22657
cttagccatc actcagctcc                                                   20


<210> 22658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22658
ctgctgcctt agccatcact                                                   20


<210> 22659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22659
cactcgacat gctgctgcct                                                   20


<210> 22660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 22660
tcccctcaat tgtcagacaa                                                   20


<210> 22661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22661
cagactttcc cctcaattgt                                                   20


<210> 22662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22662
ccatctgctc agtaatgcta                                                   20


<210> 22663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22663
cccctgtgtg cccatctgct                                                   20


<210> 22664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22664
acctctggaa cttcagttaa                                                   20


<210> 22665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22665
cacctctgga acttcagtta                                                   20


<210> 22666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22666
ccacctctgg aacttcagtt                                                   20


<210> 22667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22667
cattcccacc tctggaactt                                                   20


<210> 22668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22668
acccacccca ttcccacctc                                                   20


<210> 22669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22669
ccaaggtttt acctcctccc                                                   20


<210> 22670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22670
cattcctcag ggctctgcca                                                   20


<210> 22671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22671
tcattcctca gggctctgcc                                                   20


<210> 22672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22672
caactcacac tcattcctca                                                   20


<210> 22673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22673
tcaactcaca ctcattcctc                                                   20


<210> 22674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22674
ctcaactcac actcattcct                                                   20


<210> 22675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22675
actgtgctgc cccttcttct                                                   20


<210> 22676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22676
tactgtgctg ccccttcttc                                                   20


<210> 22677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22677
ccacaccatt gctcacctcc                                                   20


<210> 22678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 22678
catgctctgg aatccaccta                                                   20


<210> 22679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22679
cctcacatct caccatgctc                                                   20


<210> 22680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22680
tgagtcttat ttgcaagacc                                                   20


<210> 22681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22681
agaccctgag tcttatttgc                                                   20


<210> 22682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22682
ctctcaactg ggaagaccct                                                   20


<210> 22683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22683
ctcacttact ctcaactggg                                                   20


<210> 22684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22684
tctctcactt actctcaact                                                   20


<210> 22685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22685
ctctctcact tactctcaac                                                   20


<210> 22686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22686
acacctcttg aagagagccc                                                   20


<210> 22687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22687
ctggacacac ctcttgaaga                                                   20


<210> 22688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22688
cactggacac acctcttgaa                                                   20


<210> 22689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22689
cccactggac acacctcttg                                                   20


<210> 22690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22690
aactctctgc caattcccac                                                   20


<210> 22691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22691
ctggctctgc agggaaagat                                                   20


<210> 22692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22692
tctggctctg cagggaaaga                                                   20


<210> 22693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22693
cttgtctggc tctgcaggga                                                   20


<210> 22694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22694
atttcttgtc tggctctgca                                                   20


<210> 22695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22695
catttcttgt ctggctctgc                                                   20


<210> 22696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22696
ccatttcttg tctggctctg                                                   20


<210> 22697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22697
cttttctacc atttcttgtc                                                   20


<210> 22698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22698
aaacacccat tctagagtgg                                                   20


<210> 22699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22699
cagaaacacc cattctagag                                                   20


<210> 22700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22700
aaacagaaac acccattcta                                                   20


<210> 22701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22701
gtaaacagaa acacccattc                                                   20


<210> 22702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22702
ttcgttctct tatctgtaaa                                                   20


<210> 22703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22703
aggttctctc ctctcacccc                                                   20


<210> 22704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22704
cttcccctct gtggcctgat                                                   20


<210> 22705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22705
gcttcccctc tgtggcctga                                                   20


<210> 22706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22706
gacttgatgc ttcccctctg                                                   20


<210> 22707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22707
caaggcaaac tttctgaaat                                                   20


<210> 22708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22708
acaaggcaaa ctttctgaaa                                                   20


<210> 22709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22709
ggatggggag gccagagaca                                                   20


<210> 22710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22710
aggatgggga ggccagagac                                                   20


<210> 22711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22711
tggtgaggat ggggaggcca                                                   20


<210> 22712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22712
gatggtgagg atggggaggc                                                   20


<210> 22713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22713
ggttgatggt gaggatgggg                                                   20


<210> 22714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22714
aggttgatgg tgaggatggg                                                   20


<210> 22715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22715
tgaggttgat ggtgaggatg                                                   20


<210> 22716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22716
atgaggttga tggtgaggat                                                   20


<210> 22717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22717
catgaggttg atggtgagga                                                   20


<210> 22718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22718
cccccatgag gttgatggtg                                                   20


<210> 22719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22719
gcccccatga ggttgatggt                                                   20


<210> 22720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22720
ttcagccccc atgaggttga                                                   20


<210> 22721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22721
actactcttc agcccccatg                                                   20


<210> 22722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22722
gactactctt cagcccccat                                                   20


<210> 22723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22723
gtagcccagc gactactctt                                                   20


<210> 22724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22724
ctccactgtc accagtagcc                                                   20


<210> 22725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22725
aagatctcca ctgtcaccag                                                   20


<210> 22726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22726
tctaagatct ccactgtcac                                                   20


<210> 22727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22727
gctcattgtg tggggcctct                                                   20


<210> 22728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22728
ccatcaaagc tcattgtgtg                                                   20


<210> 22729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22729
tccatcaaag ctcattgtgt                                                   20


<210> 22730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22730
gtccatcaaa gctcattgtg                                                   20


<210> 22731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22731
gaaacaaaag tagtccatca                                                   20


<210> 22732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22732
tgagaattca gaaacaaaag                                                   20


<210> 22733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22733
tactgagaat tcagaaacaa                                                   20


<210> 22734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22734
attcttgatt actgagaatt                                                   20


<210> 22735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22735
ttaggcaatt cttgattact                                                   20


<210> 22736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22736
acccagagga aaaaagaatt                                                   20


<210> 22737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22737
cacccagagg aaaaaagaat                                                   20


<210> 22738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22738
tttagacacc cagaggaaaa                                                   20


<210> 22739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22739
tcctgtcttt agacacccag                                                   20


<210> 22740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22740
atcctgtctt tagacaccca                                                   20


<210> 22741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22741
aaatcctgtc tttagacacc                                                   20


<210> 22742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22742
taggtctaaa atcctgtctt                                                   20


<210> 22743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22743
agtatcttca ctgtttccgt                                                   20


<210> 22744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22744
cagtatcttc actgtttccg                                                   20


<210> 22745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22745
aggaagggag aaagcagtcc                                                   20


<210> 22746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22746
atggggagga agggagaaag                                                   20


<210> 22747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22747
gaaatgggga ggaagggaga                                                   20


<210> 22748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22748
cttggaaatg gggaggaagg                                                   20


<210> 22749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22749
aacttggaaa tggggaggaa                                                   20


<210> 22750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22750
aaacttggaa atggggagga                                                   20


<210> 22751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22751
taaacttgga aatggggagg                                                   20


<210> 22752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22752
gattaaactt ggaaatgggg                                                   20


<210> 22753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22753
ggattaaact tggaaatggg                                                   20


<210> 22754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22754
aaggattaaa cttggaaatg                                                   20


<210> 22755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22755
aaaggattaa acttggaaat                                                   20


<210> 22756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22756
taaaggatta aacttggaaa                                                   20


<210> 22757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22757
ttaaactaaa ggattaaact                                                   20


<210> 22758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22758
ttatttatac cttaaactaa                                                   20


<210> 22759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22759
tttatttata ccttaaacta                                                   20


<210> 22760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22760
gggattcagg caagacccct                                                   20


<210> 22761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22761
tctggttgtg ggattcaggc                                                   20


<210> 22762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22762
ctgttctggt tgtgggattc                                                   20


<210> 22763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22763
tctgttctgg ttgtgggatt                                                   20


<210> 22764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22764
tcactttctg ttctggttgt                                                   20


<210> 22765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22765
ttcactttct gttctggttg                                                   20


<210> 22766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22766
catgtcttca ctttctgttc                                                   20


<210> 22767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22767
caatcaatac gtaacaggag                                                   20


<210> 22768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22768
acaatcaata cgtaacagga                                                   20


<210> 22769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22769
cacaatcaat acgtaacagg                                                   20


<210> 22770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22770
tcacaatcaa tacgtaacag                                                   20


<210> 22771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22771
cctcacaatc aatacgtaac                                                   20


<210> 22772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22772
gcctcacaat caatacgtaa                                                   20


<210> 22773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22773
tgctcttccc acataccaca                                                   20


<210> 22774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22774
tattgtccca actcctaggc                                                   20


<210> 22775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22775
agcctattgt cccaactcct                                                   20


<210> 22776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22776
aagcctattg tcccaactcc                                                   20


<210> 22777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22777
taagagacag tgtgacctgg                                                   20


<210> 22778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22778
tagtaagaga cagtgtgacc                                                   20


<210> 22779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22779
gcctcttcac tagtaagaga                                                   20


<210> 22780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22780
caaggcctct tcactagtaa                                                   20


<210> 22781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22781
cccaaggcct cttcactagt                                                   20


<210> 22782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22782
taaacccaag gcctcttcac                                                   20


<210> 22783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22783
gtataggaaa cataaaccca                                                   20


<210> 22784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22784
agtataggaa acataaaccc                                                   20


<210> 22785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22785
ggaactgagg cctggagtat                                                   20


<210> 22786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22786
aggaactgag gcctggagta                                                   20


<210> 22787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22787
gacaaaggaa ctgaggcctg                                                   20


<210> 22788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22788
aagacaaagg aactgaggcc                                                   20


<210> 22789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22789
cttacaagac aaaggaactg                                                   20


<210> 22790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22790
acttacaaga caaaggaact                                                   20


<210> 22791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22791
tgtccccact tacaagacaa                                                   20


<210> 22792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22792
ttgtccccac ttacaagaca                                                   20


<210> 22793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22793
agactattgt ccccacttac                                                   20


<210> 22794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22794
ccctgtaagg ttccagggca                                                   20


<210> 22795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22795
aagaaccctg taaggttcca                                                   20


<210> 22796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22796
caagaaccct gtaaggttcc                                                   20


<210> 22797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22797
acaagaaccc tgtaaggttc                                                   20


<210> 22798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22798
attttcacaa gaaccctgta                                                   20


<210> 22799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22799
aattttcaca agaaccctgt                                                   20


<210> 22800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22800
ctcccttctc taattttcac                                                   20


<210> 22801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22801
agagcatatg ttggttttca                                                   20


<210> 22802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22802
tttattcaca gagcatatgt                                                   20


<210> 22803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22803
caggtgagca tttattcaca                                                   20


<210> 22804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22804
cccaggtgag catttattca                                                   20


<210> 22805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22805
cagtttctgt gatcccaggt                                                   20


<210> 22806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22806
aaaacagttt ctgtgatccc                                                   20


<210> 22807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22807
aaaaacagtt tctgtgatcc                                                   20


<210> 22808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22808
agttcttaga gcattaaaaa                                                   20


<210> 22809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22809
gcggacattc agagttctta                                                   20


<210> 22810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22810
ctgcggacat tcagagttct                                                   20


<210> 22811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22811
ctcaggcctg cggacattca                                                   20


<210> 22812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22812
atctcaggcc tgcggacatt                                                   20


<210> 22813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 22813
tccgtgggat ctcaggcctg                                                   20


<210> 22814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22814
atagatctcc gtgggatctc                                                   20


<210> 22815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22815
aatagatctc cgtgggatct                                                   20


<210> 22816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22816
gcacagcaat agatctccgt                                                   20


<210> 22817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22817
ggcacagcaa tagatctccg                                                   20


<210> 22818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22818
cagatatgtt ggcacagcaa                                                   20


<210> 22819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22819
gtcctacaga tatgttggca                                                   20


<210> 22820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22820
ttctggtcct acagatatgt                                                   20


<210> 22821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22821
ctgactaact tctggtccta                                                   20


<210> 22822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22822
cagagatgct gactaacttc                                                   20


<210> 22823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22823
ccccaggacc cttgcttgca                                                   20


<210> 22824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22824
atccccagga cccttgcttg                                                   20


<210> 22825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22825
tttatgctgc atgcatcccc                                                   20


<210> 22826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22826
atttatgctg catgcatccc                                                   20


<210> 22827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22827
ttctaggcta atgatacccc                                                   20


<210> 22828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22828
tttctaggct aatgataccc                                                   20


<210> 22829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22829
gtccattctg catcctttct                                                   20


<210> 22830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22830
tgtccattct gcatcctttc                                                   20


<210> 22831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22831
tggcagtgtc actagattct                                                   20


<210> 22832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22832
tctatagatg gcagtgtcac                                                   20


<210> 22833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22833
cagtgtcagt ctatagatgg                                                   20


<210> 22834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22834
tgtcagtgtc agtctataga                                                   20


<210> 22835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22835
tcagtgtcag tgtcagtcta                                                   20


<210> 22836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22836
aatgaaatca gtgtcagtgt                                                   20


<210> 22837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22837
tgcaataatg aaatcagtgt                                                   20


<210> 22838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22838
agatgttgca ataatgaaat                                                   20


<210> 22839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22839
tctcaaaggg tccactctga                                                   20


<210> 22840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22840
tcacaatgca tcttctcaaa                                                   20


<210> 22841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22841
atcacaatgc atcttctcaa                                                   20


<210> 22842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22842
gatcacaatg catcttctca                                                   20


<210> 22843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22843
cgtccacatg cagtgttgcc                                                   20


<210> 22844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22844
tttgaagatc cgtccacatg                                                   20


<210> 22845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22845
tggtcaaact cctgtgtttg                                                   20


<210> 22846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22846
cagtgtctga ggagactggt                                                   20


<210> 22847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22847
aaatcagtgt ctgaggagac                                                   20


<210> 22848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22848
ctgagaaatc agtgtctgag                                                   20


<210> 22849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22849
ttctgagaaa tcagtgtctg                                                   20


<210> 22850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22850
cttctgagaa atcagtgtct                                                   20


<210> 22851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22851
gcggtctcct tctgagaaat                                                   20


<210> 22852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22852
tgacatggcg gtctccttct                                                   20


<210> 22853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 22853
cttgtacccc cctgacatgg                                                   20


<210> 22854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22854
agccttgtac ccccctgaca                                                   20


<210> 22855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22855
acagtggatc agaaaaggcc                                                   20


<210> 22856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22856
ctgtcacagt ggatcagaaa                                                   20


<210> 22857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22857
cctgtcacag tggatcagaa                                                   20


<210> 22858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22858
gttagcctgt cacagtggat                                                   20


<210> 22859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22859
taacagttag cctgtcacag                                                   20


<210> 22860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22860
agataacagt tagcctgtca                                                   20


<210> 22861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22861
ctcaaatctg agataacagt                                                   20


<210> 22862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22862
agacctcaaa tctgagataa                                                   20


<210> 22863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22863
atgtcagaga cctcaaatct                                                   20


<210> 22864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22864
atgcccatga ggagatgtca                                                   20


<210> 22865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22865
ccatgcccat gaggagatgt                                                   20


<210> 22866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22866
attagtccca tgcccatgag                                                   20


<210> 22867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22867
agattagtcc catgcccatg                                                   20


<210> 22868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22868
aagattagtc ccatgcccat                                                   20


<210> 22869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22869
cgggggttgc tttccaagat                                                   20


<210> 22870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22870
cgcttcgggg gttgctttcc                                                   20


<210> 22871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22871
gccacagagt accgcttcgg                                                   20


<210> 22872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22872
tgccacagag taccgcttcg                                                   20


<210> 22873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22873
ttgccacaga gtaccgcttc                                                   20


<210> 22874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 22874
cttgccacag agtaccgctt                                                   20


<210> 22875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22875
ggcctggggt tcttgccaca                                                   20


<210> 22876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22876
atggcctggg gttcttgcca                                                   20


<210> 22877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22877
atttggaatt gtatggcctg                                                   20


<210> 22878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22878
catttggaat tgtatggcct                                                   20


<210> 22879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22879
tcatttggaa ttgtatggcc                                                   20


<210> 22880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22880
cttcctcatt tggaattgta                                                   20


<210> 22881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22881
ctcagttcag cttcctcatt                                                   20


<210> 22882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22882
gaaggttctt catctcagtt                                                   20


<210> 22883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22883
ctgaagaagg ttcttcatct                                                   20


<210> 22884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22884
ccaggctcac actctgaaga                                                   20


<210> 22885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22885
tccaggctca cactctgaag                                                   20


<210> 22886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22886
gtatccaggc tcacactctg                                                   20


<210> 22887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22887
tggggcttat gggtgtatcc                                                   20


<210> 22888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22888
gtggggctta tgggtgtatc                                                   20


<210> 22889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22889
ggtgtccatg tggggcttat                                                   20


<210> 22890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22890
gggtgtccat gtggggctta                                                   20


<210> 22891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22891
tttgcatggg tgtccatgtg                                                   20


<210> 22892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22892
atttgcatgg gtgtccatgt                                                   20


<210> 22893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22893
gatttgcatg ggtgtccatg                                                   20


<210> 22894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22894
taaaataaaa agatttgcat                                                   20


<210> 22895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22895
ataaaataaa aagatttgca                                                   20


<210> 22896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22896
ttgaaataaa ataaaataaa                                                   20


<210> 22897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22897
aaactattga aatacaaata                                                   20


<210> 22898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22898
aatctcagaa atcagcgtta                                                   20


<210> 22899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22899
tgcaccaaaa tctcagaaat                                                   20


<210> 22900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22900
gtgatggtgc accaaaatct                                                   20


<210> 22901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22901
agtgtacact gctcgggtga                                                   20


<210> 22902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22902
gggtacagtg tacactgctc                                                   20


<210> 22903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 22903
tgggtacagt gtacactgct                                                   20


<210> 22904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22904
aagagactac acactgggta                                                   20


<210> 22905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22905
gggataagag actacacact                                                   20


<210> 22906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22906
agggataaga gactacacac                                                   20


<210> 22907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22907
gagacgaagg taagggataa                                                   20


<210> 22908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22908
gtgagacgaa ggtaagggat                                                   20


<210> 22909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22909
gaaaggtgag acgaaggtaa                                                   20


<210> 22910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22910
ggaaaggtga gacgaaggta                                                   20


<210> 22911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22911
aggaaaggtg agacgaaggt                                                   20


<210> 22912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22912
tgggaggaaa ggtgagacga                                                   20


<210> 22913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22913
ttgggaggaa aggtgagacg                                                   20


<210> 22914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22914
ggggacttgg gaggaaaggt                                                   20


<210> 22915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22915
ctttggggac ttgggaggaa                                                   20


<210> 22916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22916
actttgggga cttgggagga                                                   20


<210> 22917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22917
atggactttg gggacttggg                                                   20


<210> 22918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22918
aatggacttt ggggacttgg                                                   20


<210> 22919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22919
ataatggact ttggggactt                                                   20


<210> 22920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22920
cataatggac tttggggact                                                   20


<210> 22921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22921
caatgacata atggactttg                                                   20


<210> 22922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22922
acaatgacat aatggacttt                                                   20


<210> 22923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22923
aacaatgaca taatggactt                                                   20


<210> 22924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22924
aaggcataac aatgacataa                                                   20


<210> 22925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22925
gctaagctgt gaggatgcaa                                                   20


<210> 22926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22926
agctaagctg tgaggatgca                                                   20


<210> 22927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22927
caagcaggag ctaagctgtg                                                   20


<210> 22928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22928
acaagcagga gctaagctgt                                                   20


<210> 22929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22929
cttaattaca agcaggagct                                                   20


<210> 22930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22930
gtgttcttaa ttacaagcag                                                   20


<210> 22931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22931
atgtgttctt aattacaagc                                                   20


<210> 22932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22932
catgtgttct taattacaag                                                   20


<210> 22933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22933
catcatgtgt tcttaattac                                                   20


<210> 22934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22934
taactcagga atagaaagtc                                                   20


<210> 22935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22935
tgaagtaact caggaataga                                                   20


<210> 22936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22936
taaatgaagt aactcaggaa                                                   20


<210> 22937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22937
tattctaaat gaagtaactc                                                   20


<210> 22938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22938
ttattctaaa tgaagtaact                                                   20


<210> 22939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22939
ggagactatt attctaaatg                                                   20


<210> 22940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22940
cagcaagctg gatggagttg                                                   20


<210> 22941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22941
ggcagcaagc tggatggagt                                                   20


<210> 22942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22942
cattggcagc aagctggatg                                                   20


<210> 22943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22943
ggcattggca gcaagctgga                                                   20


<210> 22944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22944
taatggcatt ggcagcaagc                                                   20


<210> 22945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22945
gaaataatgg cattggcagc                                                   20


<210> 22946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22946
gaatgaaata atggcattgg                                                   20


<210> 22947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22947
aaggaatgaa ataatggcat                                                   20


<210> 22948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22948
tgtaaaaagg aatgaaataa                                                   20


<210> 22949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22949
aatactactc agttgtaaaa                                                   20


<210> 22950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22950
gaatactact cagttgtaaa                                                   20


<210> 22951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22951
gcataccatg gaatactact                                                   20


<210> 22952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22952
aatatggtgt atgcatacca                                                   20


<210> 22953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22953
acaagtgcat aaagaaaata                                                   20


<210> 22954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22954
catcaaccaa caagtgcata                                                   20


<210> 22955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22955
ctaaatgccc atcaaccaac                                                   20


<210> 22956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22956
caactgcaaa aatatggaac                                                   20


<210> 22957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22957
agtttacaac tgcaaaaata                                                   20


<210> 22958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22958
tatgcatgct tatagcagca                                                   20


<210> 22959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22959
ttgcatatgc atgcttatag                                                   20


<210> 22960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22960
cacttgcata tgcatgctta                                                   20


<210> 22961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22961
gaaaataagc cattattaaa                                                   20


<210> 22962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22962
gtatctaccc agaggaaaat                                                   20


<210> 22963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22963
actactgggt atctacccag                                                   20


<210> 22964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22964
cactactggg tatctaccca                                                   20


<210> 22965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22965
cccactactg ggtatctacc                                                   20


<210> 22966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22966
ggtccagcaa tcccactact                                                   20


<210> 22967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22967
tggtccagca atcccactac                                                   20


<210> 22968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22968
agtagaacta ccatttggtc                                                   20


<210> 22969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22969
ctaaaagtag aactaccatt                                                   20


<210> 22970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22970
attccttaaa gaactaaaag                                                   20


<210> 22971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22971
gagattcctt aaagaactaa                                                   20


<210> 22972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22972
aacgttatgg agattcctta                                                   20


<210> 22973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22973
ccactaagga aaacgttatg                                                   20


<210> 22974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22974
aaccactaag gaaaacgtta                                                   20


<210> 22975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22975
gtaaactagt acaaccacta                                                   20


<210> 22976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22976
tgtaaactag tacaaccact                                                   20


<210> 22977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22977
ctgctggtgg gaatgtaaac                                                   20


<210> 22978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22978
aacaatttta cactgctggt                                                   20


<210> 22979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22979
aaacaatttt acactgctgg                                                   20


<210> 22980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22980
aggaaacaat tttacactgc                                                   20


<210> 22981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22981
ttggcatgga tgtaatgaaa                                                   20


<210> 22982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22982
gttggcatgg atgtaatgaa                                                   20


<210> 22983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22983
aaaaataata gatgttggca                                                   20


<210> 22984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22984
aaccaaaaaa taatagatgt                                                   20


<210> 22985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 22985
tggccataac caaaaaataa                                                   20


<210> 22986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22986
ccaccttact cctgcaagaa                                                   20


<210> 22987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22987
agataccacc ttactcctgc                                                   20


<210> 22988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 22988
atgcaaatta aaaccacaat                                                   20


<210> 22989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 22989
ctcaacatca ttaattatca                                                   20


<210> 22990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22990
gctcaacatc attaattatc                                                   20


<210> 22991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22991
tgctcaacat cattaattat                                                   20


<210> 22992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22992
tatataaatg gccaatgaac                                                   20


<210> 22993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 22993
atatataaat ggccaatgaa                                                   20


<210> 22994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 22994
ctcaaaagaa gatatataaa                                                   20


<210> 22995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22995
gaatacgcaa ttctcaaaag                                                   20


<210> 22996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22996
caagaatacg caattctcaa                                                   20


<210> 22997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22997
tccaaaagtg ggcaaaggac                                                   20


<210> 22998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 22998
tcccatccaa aagtgggcaa                                                   20


<210> 22999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 22999
atcccatcca aaagtgggca                                                   20


<210> 23000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23000
aaataatccc atccaaaagt                                                   20


<210> 23001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23001
caaataatcc catccaaaag                                                   20


<210> 23002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23002
aaacaaataa tcccatccaa                                                   20


<210> 23003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23003
agaaacacaa ataaatcagc                                                   20


<210> 23004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23004
tataagaaac acaaataaat                                                   20


<210> 23005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23005
gactaatatc cagcatctat                                                   20


<210> 23006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23006
tccagcaaaa gactaatatc                                                   20


<210> 23007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23007
gttatctatg cttccagcaa                                                   20


<210> 23008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23008
atctttgtta tctatgcttc                                                   20


<210> 23009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23009
acagacaacc cataggatga                                                   20


<210> 23010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23010
aaacagacaa cccataggat                                                   20


<210> 23011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23011
caagtaaaca gacaacccat                                                   20


<210> 23012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23012
ccaagtaaac agacaaccca                                                   20


<210> 23013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23013
gaaataatca tccaagtaaa                                                   20


<210> 23014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23014
agcaagagaa ataatcatcc                                                   20


<210> 23015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23015
aaaaagctgt tgcacagcaa                                                   20


<210> 23016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23016
ctaaaaagct gttgcacagc                                                   20


<210> 23017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23017
taaactaaaa agctgttgca                                                   20


<210> 23018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23018
tgggatctaa ttaaactaaa                                                   20


<210> 23019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23019
aaaaacaaaa ataaatagat                                                   20


<210> 23020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23020
caaaaacaaa aataaataga                                                   20


<210> 23021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23021
ccaacaaaaa caaaaataaa                                                   20


<210> 23022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23022
cgttcctgac caaggaccca                                                   20


<210> 23023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23023
aggcaaaacg ttcctgacca                                                   20


<210> 23024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23024
taggcaaaac gttcctgacc                                                   20


<210> 23025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23025
actcttctag acattggctt                                                   20


<210> 23026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23026
aactcttcta gacattggct                                                   20


<210> 23027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23027
ggaaaaactc ttctagacat                                                   20


<210> 23028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23028
taacattgga aaaactcttc                                                   20


<210> 23029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23029
aaaattctag aagataacat                                                   20


<210> 23030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23030
gaaattataa aaaattctag                                                   20


<210> 23031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23031
cctgaaatta taaaaaattc                                                   20


<210> 23032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23032
tggataaaag gcttaaatct                                                   20


<210> 23033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23033
atcaattcaa gatggataaa                                                   20


<210> 23034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23034
aatcaattca agatggataa                                                   20


<210> 23035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23035
atacaaaaat caattcaaga                                                   20


<210> 23036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23036
ccttatacaa aaatcaattc                                                   20


<210> 23037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23037
agcaagccac atgtggaaga                                                   20


<210> 23038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23038
aattagcaag ccacatgtgg                                                   20


<210> 23039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23039
gataattagc aagccacatg                                                   20


<210> 23040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23040
atggtgctgg gataattagc                                                   20


<210> 23041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23041
acaaatggtg ctgggataat                                                   20


<210> 23042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23042
cctattcaac aaatggtgct                                                   20


<210> 23043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23043
ccctattcaa caaatggtgc                                                   20


<210> 23044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23044
aggacaccct attcaacaaa                                                   20


<210> 23045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23045
acaaaaacgt aagtggggaa                                                   20


<210> 23046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23046
aacaaaaacg taagtgggga                                                   20


<210> 23047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23047
agcaaacaaa aacgtaagtg                                                   20


<210> 23048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23048
aagcaaacaa aaacgtaagt                                                   20


<210> 23049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23049
aaagcaaaca aaaacgtaag                                                   20


<210> 23050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23050
gaaaaagcaa acaaaaacgt                                                   20


<210> 23051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23051
caagcaactg atctttgaaa                                                   20


<210> 23052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23052
aaataaagcc aaatacttac                                                   20


<210> 23053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23053
gaatagagaa ctcagaaata                                                   20


<210> 23054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23054
atggaaaaga atagagaact                                                   20


<210> 23055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23055
tagaccaatg gaaaagaata                                                   20


<210> 23056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23056
catagaccaa tggaaaagaa                                                   20


<210> 23057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23057
aagcacatag accaatggaa                                                   20


<210> 23058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23058
aaaataagca catagaccaa                                                   20


<210> 23059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23059
ctggtataaa aataagcaca                                                   20


<210> 23060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23060
catgatactg gtataaaaat                                                   20


<210> 23061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23061
gtaccaaaac agcatgatac                                                   20


<210> 23062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23062
tagtatagcc tgtaccaaaa                                                   20


<210> 23063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23063
tatactacaa ggctatagta                                                   20


<210> 23064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23064
caaactatac tacaaggcta                                                   20


<210> 23065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23065
tgatttcaaa ctatactaca                                                   20


<210> 23066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23066
ctgatttcaa actatactac                                                   20


<210> 23067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23067
caaatctgga ggcatcacct                                                   20


<210> 23068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23068
agcaagaata acaaatctgg                                                   20


<210> 23069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23069
aagcaagaat aacaaatctg                                                   20


<210> 23070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23070
ctaagcaaga ataacaaatc                                                   20


<210> 23071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23071
tagccaaagc aagactaagc                                                   20


<210> 23072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23072
cacatagcca aagcaagact                                                   20


<210> 23073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23073
ggaatccaca tagccaaagc                                                   20


<210> 23074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23074
aaaaggaatc cacatagcca                                                   20


<210> 23075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23075
gaaccaaaaa ggaatccaca                                                   20


<210> 23076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23076
aaattcatag ggaaccaaaa                                                   20


<210> 23077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23077
aaaattcata gggaaccaaa                                                   20


<210> 23078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23078
taacaaccct aaaattcata                                                   20


<210> 23079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23079
ataacaaccc taaaattcat                                                   20


<210> 23080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23080
aataacaacc ctaaaattca                                                   20


<210> 23081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23081
cacatcattc ttcacagaaa                                                   20


<210> 23082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23082
aagtaccaca tcattcttca                                                   20


<210> 23083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23083
attcaataca atttccattg                                                   20


<210> 23084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23084
ttactgccaa aagcaatata                                                   20


<210> 23085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23085
gaaaatgacc ttactgccaa                                                   20


<210> 23086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23086
acacatccca tgctcatgga                                                   20


<210> 23087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23087
gggaacacat cccatgctca                                                   20


<210> 23088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23088
cacagatgac acaaacaaat                                                   20


<210> 23089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23089
tcacagatga cacaaacaaa                                                   20


<210> 23090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23090
aacactgcta aaataaatca                                                   20


<210> 23091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23091
aaaggtgaaa gatttctaca                                                   20


<210> 23092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23092
aaaaggtgaa agatttctac                                                   20


<210> 23093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23093
atacctaacc aaaaaggtga                                                   20


<210> 23094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23094
aggaatatac ctaaccaaaa                                                   20


<210> 23095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23095
taggaatata cctaaccaaa                                                   20


<210> 23096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23096
aataaaaaca aaaaaatctt                                                   20


<210> 23097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23097
aaataaaaac aaaaaaatct                                                   20


<210> 23098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23098
gaactcaatc ccttttacaa                                                   20


<210> 23099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23099
accaagctga ggaacaaatc                                                   20


<210> 23100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23100
caccaccaga aaccaagctg                                                   20


<210> 23101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23101
acaccaccag aaaccaagct                                                   20


<210> 23102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23102
actgtacacc accagaaacc                                                   20


<210> 23103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23103
gcagcactac tgtacaccac                                                   20


<210> 23104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23104
aaacaatgta tacaaatcag                                                   20


<210> 23105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23105
caaaaacaat gtatacaaat                                                   20


<210> 23106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23106
aatgaattca gtaaagtttc                                                   20


<210> 23107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23107
aaatgaattc agtaaagttt                                                   20


<210> 23108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23108
tctaataaat gaattcagta                                                   20


<210> 23109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23109
ctagatctaa taaatgaatt                                                   20


<210> 23110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23110
agactcatcc aaaaagctcc                                                   20


<210> 23111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23111
accctaaaga ctcatccaaa                                                   20


<210> 23112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23112
cgtatgccta ggaaacccta                                                   20


<210> 23113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23113
aatgatatga tcgtatgcct                                                   20


<210> 23114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23114
caatgatatg atcgtatgcc                                                   20


<210> 23115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23115
aatccaaatc agtaaagggg                                                   20


<210> 23116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23116
gggaatccaa atcagtaaag                                                   20


<210> 23117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23117
agggaatcca aatcagtaaa                                                   20


<210> 23118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23118
aagggaatcc aaatcagtaa                                                   20


<210> 23119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23119
aaagggaatc caaatcagta                                                   20


<210> 23120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23120
taaataaagg gaatccaaat                                                   20


<210> 23121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23121
agacaagaga aataaataaa                                                   20


<210> 23122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23122
cagacaagag aaataaataa                                                   20


<210> 23123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23123
tcagacaaga gaaataaata                                                   20


<210> 23124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23124
tagccagagc aatcagacaa                                                   20


<210> 23125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23125
cctagccaga gcaatcagac                                                   20


<210> 23126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23126
gaagtcctag ccagagcaat                                                   20


<210> 23127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23127
agtactggaa gtcctagcca                                                   20


<210> 23128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23128
atagtactgg aagtcctagc                                                   20


<210> 23129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23129
caacatagta ctggaagtcc                                                   20


<210> 23130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23130
tctatccaac atagtactgg                                                   20


<210> 23131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23131
atttctatcc aacatagtac                                                   20


<210> 23132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23132
ttcaccattt ctatccaaca                                                   20


<210> 23133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23133
ctgagaactg aaacaagaca                                                   20


<210> 23134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23134
cctgagaact gaaacaagac                                                   20


<210> 23135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23135
ttccccctga gaactgaaac                                                   20


<210> 23136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23136
aagttgaaag cattccccct                                                   20


<210> 23137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23137
accaaacagg gaaaagttga                                                   20


<210> 23138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23138
acattatacc aaacagggaa                                                   20


<210> 23139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23139
agccaacatt ataccaaaca                                                   20


<210> 23140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23140
cagccaacat tataccaaac                                                   20


<210> 23141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23141
acagccaaca ttataccaaa                                                   20


<210> 23142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23142
agccatctat gacaaatcca                                                   20


<210> 23143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23143
gacatactcc aaggtaataa                                                   20


<210> 23144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23144
catagaaggg acatactcca                                                   20


<210> 23145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23145
gcatagaagg gacatactcc                                                   20


<210> 23146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23146
tcaaccaaat tggcatagaa                                                   20


<210> 23147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23147
ctcaaccaaa ttggcataga                                                   20


<210> 23148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23148
cctcaaccaa attggcatag                                                   20


<210> 23149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23149
aaccctcaac caaattggca                                                   20


<210> 23150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23150
attaaaaccc tcaaccaaat                                                   20


<210> 23151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23151
gaaaagcatt tgacaaaatc                                                   20


<210> 23152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23152
catctcaata ggtgcaggaa                                                   20


<210> 23153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23153
atgatcatct caataggtgc                                                   20


<210> 23154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23154
tatgatcatc tcaataggtg                                                   20


<210> 23155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23155
aatcatatga tcatctcaat                                                   20


<210> 23156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23156
aaatcatatg atcatctcaa                                                   20


<210> 23157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23157
aatgctgcac gtcacataaa                                                   20


<210> 23158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23158
agggatgatt taacatacac                                                   20


<210> 23159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23159
ggtttcatac cagggaggta                                                   20


<210> 23160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23160
gggtttcata ccagggaggt                                                   20


<210> 23161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23161
ggggtttcat accagggagg                                                   20


<210> 23162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23162
aagggggttt cataccaggg                                                   20


<210> 23163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23163
caagggggtt tcataccagg                                                   20


<210> 23164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23164
atcaaggggg tttcatacca                                                   20


<210> 23165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23165
gatcaagggg gtttcatacc                                                   20


<210> 23166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23166
tgatcaaggg ggtttcatac                                                   20


<210> 23167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23167
ataacacacc atgatcaagg                                                   20


<210> 23168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23168
gataacacac catgatcaag                                                   20


<210> 23169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23169
agataacaca ccatgatcaa                                                   20


<210> 23170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23170
aagataacac accatgatca                                                   20


<210> 23171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23171
aaagataaca caccatgatc                                                   20


<210> 23172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23172
tgaatccaac acatatccaa                                                   20


<210> 23173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23173
aaaaatcctc aacaaaatgc                                                   20


<210> 23174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23174
gacaatatcc ctgatgaaca                                                   20


<210> 23175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23175
ggacttttaa aaaagaacta                                                   20


<210> 23176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23176
ccagaaaagg acttttaaaa                                                   20


<210> 23177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23177
cctaatacca aaaccagaaa                                                   20


<210> 23178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23178
ccctaatacc aaaaccagaa                                                   20


<210> 23179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23179
tatcacccta ataccaaaac                                                   20


<210> 23180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23180
cctaaatcat tttatgaagc                                                   20


<210> 23181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23181
tcctcctaaa tcattttatg                                                   20


<210> 23182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23182
ttccaaaaga tgcagaaaga                                                   20


<210> 23183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23183
attccaaaag atgcagaaag                                                   20


<210> 23184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23184
tattccaaaa gatgcagaaa                                                   20


<210> 23185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23185
actattccaa aagatgcaga                                                   20


<210> 23186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23186
tgaaactatt ccaaaagatg                                                   20


<210> 23187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23187
ttttattgaa actattccaa                                                   20


<210> 23188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23188
tcagacattc aaagaagaat                                                   20


<210> 23189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23189
attctatcag acattcaaag                                                   20


<210> 23190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23190
tgaattctat cagacattca                                                   20


<210> 23191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23191
gattcacagc tgaattctat                                                   20


<210> 23192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23192
ccaggagcag actggattca                                                   20


<210> 23193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23193
aaaaaagtcc aggagcagac                                                   20


<210> 23194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23194
aaggaaaaaa agtccaggag                                                   20


<210> 23195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23195
gccaaggaaa aaaagtccag                                                   20


<210> 23196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23196
ttgccaagga aaaaaagtcc                                                   20


<210> 23197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23197
attgccaagg aaaaaaagtc                                                   20


<210> 23198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23198
caaaaattgc caaggaaaaa                                                   20


<210> 23199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23199
cagtaattca aaaattgcca                                                   20


<210> 23200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23200
acagtaattc aaaaattgcc                                                   20


<210> 23201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23201
aacaagtagc gagattgaaa                                                   20


<210> 23202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23202
acagaccaat aacaagtagc                                                   20


<210> 23203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23203
ctaaacagac caataacaag                                                   20


<210> 23204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23204
actctaaaca gaccaataac                                                   20


<210> 23205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23205
aaagtaatag aaactctaaa                                                   20


<210> 23206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23206
tagattaaat cagaaagtaa                                                   20


<210> 23207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23207
ctgtcttaga ttaaatcaga                                                   20


<210> 23208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23208
acaactgtct tagattaaat                                                   20


<210> 23209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23209
ctggaaatat acaactgtct                                                   20


<210> 23210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23210
agaggagatg aataaattcc                                                   20


<210> 23211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23211
acaaactaga aaatttagag                                                   20


<210> 23212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23212
gcacaaacta gaaaatttag                                                   20


<210> 23213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23213
tgcacaaact agaaaattta                                                   20


<210> 23214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23214
tttgcacaaa ctagaaaatt                                                   20


<210> 23215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23215
acacctttat ttgcacaaac                                                   20


<210> 23216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23216
tacaaaaaaa aaatcattca                                                   20


<210> 23217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23217
atacaaaaaa aaaatcattc                                                   20


<210> 23218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23218
agatattaca actgatacca                                                   20


<210> 23219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23219
ctcaattaga aataaaatgg                                                   20


<210> 23220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23220
agctcaatta gaaataaaat                                                   20


<210> 23221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23221
aagctcaatt agaaataaaa                                                   20


<210> 23222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23222
aagatccaaa taagctcaat                                                   20


<210> 23223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23223
agaagagaga agatccaaat                                                   20


<210> 23224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23224
taaccaagaa aagaagagag                                                   20


<210> 23225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23225
gattaaccaa gaaaagaaga                                                   20


<210> 23226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23226
aagattaacc aagaaaagaa                                                   20


<210> 23227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23227
gcaagattaa ccaagaaaag                                                   20


<210> 23228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23228
ttggcaagat taaccaagaa                                                   20


<210> 23229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23229
gaccattggc aagattaacc                                                   20


<210> 23230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23230
aaaattgatt gaccattggc                                                   20


<210> 23231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23231
atagaaaatt gattgaccat                                                   20


<210> 23232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23232
gcgggttctt taaaaagata                                                   20


<210> 23233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23233
caaaaagcgg gttctttaaa                                                   20


<210> 23234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23234
agataagtga aacaaaaagc                                                   20


<210> 23235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 23235
aagataagtg aaacaaaaag                                                   20


<210> 23236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23236
caaaagataa gtgaaacaaa                                                   20


<210> 23237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23237
ataataataa tacaaaagat                                                   20


<210> 23238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23238
taaaaataat aataatacaa                                                   20


<210> 23239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23239
aggaataaca aagatcaggg                                                   20


<210> 23240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23240
aaaaggaata acaaagatca                                                   20


<210> 23241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23241
gaaaaggaat aacaaagatc                                                   20


<210> 23242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23242
agaaaaggaa taacaaagat                                                   20


<210> 23243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23243
gcagaagaaa aggaataaca                                                   20


<210> 23244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23244
cccaaaccaa gcagaagaaa                                                   20


<210> 23245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23245
acccaaacca agcagaagaa                                                   20


<210> 23246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23246
aacagaccca aaccaagcag                                                   20


<210> 23247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23247
caaaacagac ccaaaccaag                                                   20


<210> 23248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23248
gaacaaaaca gacccaaacc                                                   20


<210> 23249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23249
ttagagaaac aagaacaaaa                                                   20


<210> 23250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23250
cctcaaggaa ttagagaaac                                                   20


<210> 23251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23251
ggtcacacct caaggaatta                                                   20


<210> 23252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23252
aaggtcacac ctcaaggaat                                                   20


<210> 23253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23253
taatctaagg tcacacctca                                                   20


<210> 23254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23254
ataatctaag gtcacacctc                                                   20


<210> 23255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23255
gaggacaaat agataatcta                                                   20


<210> 23256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23256
agaggacaaa tagataatct                                                   20


<210> 23257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23257
aaagtatgaa agaggacaaa                                                   20


<210> 23258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23258
tacatcaaaa agtatgaaag                                                   20


<210> 23259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23259
ctacatcaaa aagtatgaaa                                                   20


<210> 23260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23260
acctacatca aaaagtatga                                                   20


<210> 23261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23261
cattaaatac ctacatcaaa                                                   20


<210> 23262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23262
agtgctaaga ggaaagctca                                                   20


<210> 23263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23263
ctaaagcagt gctaagagga                                                   20


<210> 23264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23264
acagctaaag cagtgctaag                                                   20


<210> 23265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23265
tacagctaaa gcagtgctaa                                                   20


<210> 23266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23266
gatacagcta aagcagtgct                                                   20


<210> 23267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23267
cctctgggat acagctaaag                                                   20


<210> 23268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23268
aaacctctgg gatacagcta                                                   20


<210> 23269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23269
ttatcaaaac ctctgggata                                                   20


<210> 23270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23270
cacaacttat caaaacctct                                                   20


<210> 23271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23271
acacaactta tcaaaacctc                                                   20


<210> 23272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23272
ttttttgaac tgaatgataa                                                   20


<210> 23273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23273
caacaatgaa atcaagatgg                                                   20


<210> 23274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23274
ggtcaacaat gaaatcaaga                                                   20


<210> 23275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23275
tttgggtcaa caatgaaatc                                                   20


<210> 23276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23276
tctgctcttg aatgatcttt                                                   20


<210> 23277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23277
atctgctctt gaatgatctt                                                   20


<210> 23278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23278
aacctcggag ttaactccaa                                                   20


<210> 23279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23279
gcacagtcga ataaacctcg                                                   20


<210> 23280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 23280
gagcacagtc gaataaacct                                                   20


<210> 23281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23281
tcaggtatcc tctcagagca                                                   20


<210> 23282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23282
ttatgtcagg tatcctctca                                                   20


<210> 23283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23283
aattatgtca ggtatcctct                                                   20


<210> 23284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23284
aagaaaatag aaattatgtc                                                   20


<210> 23285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23285
taagaaaata gaaattatgt                                                   20


<210> 23286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23286
tctcaataaa tttaagaaaa                                                   20


<210> 23287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23287
taacaaatct caataaattt                                                   20


<210> 23288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23288
ctctaagata gaccacgtga                                                   20


<210> 23289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23289
acatggaata ttctctaaga                                                   20


<210> 23290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23290
cagcacatgg aatattctct                                                   20


<210> 23291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23291
acattctttt catcagcaca                                                   20


<210> 23292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23292
agaatataca ttcttttcat                                                   20


<210> 23293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23293
aacattctac caaacaactg                                                   20


<210> 23294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23294
cctagaacaa atggacttaa                                                   20


<210> 23295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23295
aaactgtaac ctagaacaaa                                                   20


<210> 23296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23296
aatgaactta aactgtaacc                                                   20


<210> 23297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23297
atcaagacag aaagtcaaca                                                   20


<210> 23298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23298
agacaggtca tcaagacaga                                                   20


<210> 23299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23299
cactagacag gtcatcaaga                                                   20


<210> 23300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23300
acagcactag acaggtcatc                                                   20


<210> 23301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23301
ttccactgac agcactagac                                                   20


<210> 23302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23302
attccactga cagcactaga                                                   20


<210> 23303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23303
caatattcca ctgacagcac                                                   20


<210> 23304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23304
ggggatcaat attccactga                                                   20


<210> 23305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23305
cagcaatata ataatagtgg                                                   20


<210> 23306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23306
acagcaatat aataatagtg                                                   20


<210> 23307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23307
gacagcaata taataatagt                                                   20


<210> 23308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23308
agacagcaat ataataatag                                                   20


<210> 23309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23309
aatagacagc aatataataa                                                   20


<210> 23310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23310
gacctaagaa atgaaataga                                                   20


<210> 23311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23311
actagaccta agaaatgaaa                                                   20


<210> 23312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23312
aaacaattac tactagacct                                                   20


<210> 23313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23313
atttataaaa caattactac                                                   20


<210> 23314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23314
tacatatgca cctaacactg                                                   20


<210> 23315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23315
aatacatatg cacctaacac                                                   20


<210> 23316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23316
tgataaaata attggtctaa                                                   20


<210> 23317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23317
atatataatg ataaaataat                                                   20


<210> 23318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23318
cagttaaaaa aagacaaaga                                                   20


<210> 23319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23319
acagttaaaa aaagacaaag                                                   20


<210> 23320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23320
aacagttaaa aaaagacaaa                                                   20


<210> 23321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23321
acaacagtta aaaaaagaca                                                   20


<210> 23322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23322
aaagcaacaa cagttaaaaa                                                   20


<210> 23323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23323
aacagacctt aaagcaacaa                                                   20


<210> 23324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23324
atcagagaaa acagacctta                                                   20


<210> 23325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23325
tattcttata tcagagaaaa                                                   20


<210> 23326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23326
gagtagctat tcttatatca                                                   20


<210> 23327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23327
aggagtagct attcttatat                                                   20


<210> 23328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23328
aaaccaaaag caagcaggag                                                   20


<210> 23329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23329
tggaaaccaa aagcaagcag                                                   20


<210> 23330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23330
aatggaaacc aaaagcaagc                                                   20


<210> 23331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23331
aaatggaaac caaaagcaag                                                   20


<210> 23332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23332
tgcaaatgga aaccaaaagc                                                   20


<210> 23333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23333
tccatgcaaa tggaaaccaa                                                   20


<210> 23334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23334
gaaaagatat tccatgcaaa                                                   20


<210> 23335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23335
ttaaggtaaa gagatgggaa                                                   20


<210> 23336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23336
taaacttaag gtaaagagat                                                   20


<210> 23337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23337
ataaacttaa ggtaaagaga                                                   20


<210> 23338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23338
ccacataaac ttaaggtaaa                                                   20


<210> 23339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23339
agccacataa acttaaggta                                                   20


<210> 23340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23340
taaggagcca cataaactta                                                   20


<210> 23341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23341
ataaggagcc acataaactt                                                   20


<210> 23342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23342
agactcacct aacacataag                                                   20


<210> 23343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23343
agagactcac ctaacacata                                                   20


<210> 23344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23344
aagagactca cctaacacat                                                   20


<210> 23345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23345
caagtatcta ctgtcttcaa                                                   20


<210> 23346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23346
accaagtatc tactgtcttc                                                   20


<210> 23347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23347
aaaaaaaaaa tccaccaacc                                                   20


<210> 23348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23348
aaatatacag aagggcagaa                                                   20


<210> 23349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23349
aaaatataca gaagggcaga                                                   20


<210> 23350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23350
acttaaaata tacagaaggg                                                   20


<210> 23351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23351
tccacttaaa atatacagaa                                                   20


<210> 23352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23352
atccacttaa aatatacaga                                                   20


<210> 23353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23353
gatccactta aaatatacag                                                   20


<210> 23354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23354
aatgatccac ttaaaatata                                                   20


<210> 23355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23355
cacatctcaa tactgatgtt                                                   20


<210> 23356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23356
aactagcata atgaatagaa                                                   20


<210> 23357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23357
ataactagca taatgaatag                                                   20


<210> 23358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23358
gcaataacta gcataatgaa                                                   20


<210> 23359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23359
aaaggaatta aggcaataac                                                   20


<210> 23360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23360
cacaataaaa aaaggaatta                                                   20


<210> 23361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23361
acacaataaa aaaaggaatt                                                   20


<210> 23362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23362
aacaataaca caataaaaaa                                                   20


<210> 23363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23363
aaacaataac acaataaaaa                                                   20


<210> 23364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23364
ccttaaagca taaatatcaa                                                   20


<210> 23365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23365
tccttaaagc ataaatatca                                                   20


<210> 23366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23366
accaaaatag aacctcctta                                                   20


<210> 23367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23367
aaccttaaaa tacaccaaaa                                                   20


<210> 23368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23368
gcactacaag aaatgctaaa                                                   20


<210> 23369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23369
agcactacaa gaaatgctaa                                                   20


<210> 23370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23370
cactaccaag ccagcactac                                                   20


<210> 23371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23371
agaattttcc actaccaagc                                                   20


<210> 23372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23372
tgagagaatt ttccactacc                                                   20


<210> 23373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23373
ttcagacaaa caaatggtga                                                   20


<210> 23374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23374
ttttcagaca aacaaatggt                                                   20


<210> 23375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23375
gtttttttca gacaaacaaa                                                   20


<210> 23376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23376
agacaagata aagttttttt                                                   20


<210> 23377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23377
tcataagtga agacaagata                                                   20


<210> 23378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23378
taagcttcat aagtgaagac                                                   20


<210> 23379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23379
gaaactaagc ttcataagtg                                                   20


<210> 23380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23380
gaagagaaac taagcttcat                                                   20


<210> 23381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23381
atattgtatg aagagaaact                                                   20


<210> 23382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23382
agccaagaat attgtatgaa                                                   20


<210> 23383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23383
ccagccaaga atattgtatg                                                   20


<210> 23384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23384
aaacaaaata attgccagcc                                                   20


<210> 23385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23385
tcctgaaaca aaataattgc                                                   20


<210> 23386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23386
agggattagg gtcccatctt                                                   20


<210> 23387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23387
ttgcaagcca gaagggatta                                                   20


<210> 23388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23388
cttgcaagcc agaagggatt                                                   20


<210> 23389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23389
ccttgcaagc cagaagggat                                                   20


<210> 23390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23390
tgaaaccttg caagccagaa                                                   20


<210> 23391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23391
ctgaaacctt gcaagccaga                                                   20


<210> 23392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23392
actgaaacct tgcaagccag                                                   20


<210> 23393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23393
tcaactgaaa ccttgcaagc                                                   20


<210> 23394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23394
tttctcaact gaaaccttgc                                                   20


<210> 23395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23395
gatttacata agattaacag                                                   20


<210> 23396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23396
tctgatttac ataagattaa                                                   20


<210> 23397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23397
aaaggttatc tgatttacat                                                   20


<210> 23398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23398
tcagataacc tataaaggaa                                                   20


<210> 23399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23399
ctcagataac ctataaagga                                                   20


<210> 23400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23400
aagcctcaga taacctataa                                                   20


<210> 23401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23401
aaagcctcag ataacctata                                                   20


<210> 23402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23402
gagctgtgag acaaaagcct                                                   20


<210> 23403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23403
tcttaagagc tgtgagacaa                                                   20


<210> 23404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23404
aaaagaatct taagagctgt                                                   20


<210> 23405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23405
gacaaagaaa agaatcttaa                                                   20


<210> 23406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23406
aagacaaaga aaagaatctt                                                   20


<210> 23407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23407
tctaaagtca agacaaagaa                                                   20


<210> 23408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23408
ggttatctaa agtcaagaca                                                   20


<210> 23409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23409
acatcaggtt atctaaagtc                                                   20


<210> 23410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23410
aatagacatc aggttatcta                                                   20


<210> 23411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23411
cacctaggca aatagacatc                                                   20


<210> 23412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23412
tcacctaggc aaatagacat                                                   20


<210> 23413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23413
aagatcatca cctaggcaaa                                                   20


<210> 23414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23414
cacaaaaaag atcatcacct                                                   20


<210> 23415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23415
tcacaaaaaa gatcatcacc                                                   20


<210> 23416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23416
ctctgaaatg tgtcacaaaa                                                   20


<210> 23417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23417
atccaaatac aagaagctca                                                   20


<210> 23418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23418
tatagatatc caaatacaag                                                   20


<210> 23419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23419
aaatatagat atccaaatac                                                   20


<210> 23420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23420
ccctggcctt gttagaaata                                                   20


<210> 23421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23421
gaaaacttcc ctggccttgt                                                   20


<210> 23422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23422
ataattgagg aaaacttccc                                                   20


<210> 23423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23423
cttatttgag ggaataattg                                                   20


<210> 23424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23424
acttatttga gggaataatt                                                   20


<210> 23425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23425
agtttggaaa acttatttga                                                   20


<210> 23426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23426
aagtttggaa aacttatttg                                                   20


<210> 23427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23427
aaagtttgga aaacttattt                                                   20


<210> 23428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23428
agaatagaaa tctaaaagtt                                                   20


<210> 23429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23429
aaggaagaat agaaatctaa                                                   20


<210> 23430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23430
tgggtgttcc caaggaagaa                                                   20


<210> 23431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23431
aataatgggt gttcccaagg                                                   20


<210> 23432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23432
aagaataatg ggtgttccca                                                   20


<210> 23433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23433
taagaataat gggtgttccc                                                   20


<210> 23434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23434
caaccaaacc taagaataat                                                   20


<210> 23435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23435
acaaccaaac ctaagaataa                                                   20


<210> 23436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23436
catgtgaaac aaccaaacct                                                   20


<210> 23437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23437
gacaaatcgg ccaataaatt                                                   20


<210> 23438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 23438
tttttaaaaa aatgacaaat                                                   20


<210> 23439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23439
aactaagaca cacaaaaaga                                                   20


<210> 23440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23440
cccaaactaa gacacacaaa                                                   20


<210> 23441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23441
gcttttaata gacccaaact                                                   20


<210> 23442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23442
ctcgaagaca aagcttttaa                                                   20


<210> 23443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23443
aacttcagag ctcgaagaca                                                   20


<210> 23444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23444
agaaagaact tcagagctcg                                                   20


<210> 23445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23445
aagtagaaga aagaacttca                                                   20


<210> 23446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23446
acaagtagaa gaaagaactt                                                   20


<210> 23447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23447
agactagaac aagtagaaga                                                   20


<210> 23448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23448
caatagacta gaacaagtag                                                   20


<210> 23449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23449
caacaataga ctagaacaag                                                   20


<210> 23450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23450
tttcaacaat agactagaac                                                   20


<210> 23451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23451
ggaaagtttc aacaatagac                                                   20


<210> 23452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23452
gcagtggaaa gtttcaacaa                                                   20


<210> 23453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23453
gaaatacaaa atgcagtgga                                                   20


<210> 23454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23454
tagagaaata caaaatgcag                                                   20


<210> 23455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23455
acttagagaa atacaaaatg                                                   20


<210> 23456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23456
ggaaatggaa gactcactta                                                   20


<210> 23457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23457
ctggaaatgg aagactcact                                                   20


<210> 23458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23458
atcacaactt ctggaaatgg                                                   20


<210> 23459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23459
acaatcacaa cttctggaaa                                                   20


<210> 23460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23460
gaaaaaacaa tcacaacttc                                                   20


<210> 23461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23461
tctccagaga aatagatata                                                   20


<210> 23462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23462
tggaaaattc tccagagaaa                                                   20


<210> 23463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23463
tatggatgga aaattctcca                                                   20


<210> 23464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23464
gatatggatg gaaaattctc                                                   20


<210> 23465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23465
ttaaaacaac aagatatgga                                                   20


<210> 23466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23466
atttttaaaa caacaagata                                                   20


<210> 23467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23467
aaagaaattt ttaaaacaac                                                   20


<210> 23468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23468
gaaagataaa aaccaactta                                                   20


<210> 23469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23469
attcaaggag acaccagaga                                                   20


<210> 23470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23470
agtgattcaa ggagacacca                                                   20


<210> 23471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23471
taagtgattc aaggagacac                                                   20


<210> 23472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23472
tgattattaa gtgattcaag                                                   20


<210> 23473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23473
gctgattatt aagtgattca                                                   20


<210> 23474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23474
ggctgattat taagtgattc                                                   20


<210> 23475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23475
aattcagaag gctgattatt                                                   20


<210> 23476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23476
aaaaaaaaaa agaattcaga                                                   20


<210> 23477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23477
aaaaaaaaaa aagaattcag                                                   20


<210> 23478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23478
aaaaaaaaaa aaaaagaatt                                                   20


<210> 23479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23479
catctcaaaa aaaaaaaaaa                                                   20


<210> 23480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23480
cactccagcc tgggcaacaa                                                   20


<210> 23481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23481
tgcactccag cctgggcaac                                                   20


<210> 23482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23482
gcgccattgc actccagcct                                                   20


<210> 23483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23483
cgcgccattg cactccagcc                                                   20


<210> 23484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23484
gagatcgcgc cattgcactc                                                   20


<210> 23485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23485
ggcagaggtt gcggtgagct                                                   20


<210> 23486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23486
tgggaggcag aggttgcggt                                                   20


<210> 23487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 23487
aacctgggag gcagaggttg                                                   20


<210> 23488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23488
tgcttgaacc tgggaggcag                                                   20


<210> 23489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23489
ttgcttgaac ctgggaggca                                                   20


<210> 23490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23490
aattgcttga acctgggagg                                                   20


<210> 23491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23491
gagaattgct tgaacctggg                                                   20


<210> 23492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23492
ggagaattgc ttgaacctgg                                                   20


<210> 23493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23493
caggagaatt gcttgaacct                                                   20


<210> 23494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23494
gcaggagaat tgcttgaacc                                                   20


<210> 23495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23495
tactcaggag actgaggcag                                                   20


<210> 23496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23496
gctactcagg agactgaggc                                                   20


<210> 23497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23497
agctactcag gagactgagg                                                   20


<210> 23498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23498
cccagctact caggagactg                                                   20


<210> 23499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23499
tcccagctac tcaggagact                                                   20


<210> 23500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23500
ctgtaatccc agctactcag                                                   20


<210> 23501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23501
gcctgtaatc ccagctactc                                                   20


<210> 23502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23502
tgcctgtaat cccagctact                                                   20


<210> 23503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23503
gtggtgcatg cctgtaatcc                                                   20


<210> 23504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23504
acaaaattag ctagatgtgg                                                   20


<210> 23505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23505
aatacaaaat tagctagatg                                                   20


<210> 23506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23506
ctaaaaaata caaaattagc                                                   20


<210> 23507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23507
tctactaaaa aatacaaaat                                                   20


<210> 23508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23508
accagcctga agccaacatg                                                   20


<210> 23509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23509
agaccagcct gaagccaaca                                                   20


<210> 23510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23510
agaagttcaa gaccagcctg                                                   20


<210> 23511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23511
tgaggtcaga agttcaagac                                                   20


<210> 23512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23512
tcacctgagg tcagaagttc                                                   20


<210> 23513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23513
ggcagatcac ctgaggtcag                                                   20


<210> 23514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23514
gtgggcagat cacctgaggt                                                   20


<210> 23515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23515
caaggtgggc agatcacctg                                                   20


<210> 23516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23516
ccaaggtggg cagatcacct                                                   20


<210> 23517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23517
ctttgggagg ccaaggtggg                                                   20


<210> 23518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23518
gcactttggg aggccaaggt                                                   20


<210> 23519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23519
agcactttgg gaggccaagg                                                   20


<210> 23520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23520
ctcagcactt tgggaggcca                                                   20


<210> 23521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23521
tctcagcact ttgggaggcc                                                   20


<210> 23522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23522
tgtaatctca gcactttggg                                                   20


<210> 23523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23523
ctgtaatctc agcactttgg                                                   20


<210> 23524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23524
gcctgtaatc tcagcacttt                                                   20


<210> 23525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23525
cgcctgtaat ctcagcactt                                                   20


<210> 23526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23526
gtagctcacg cctgtaatct                                                   20


<210> 23527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23527
gaattcaggg ctgggcacag                                                   20


<210> 23528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23528
aaagaattca gggctgggca                                                   20


<210> 23529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23529
cagataaaga attcagggct                                                   20


<210> 23530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23530
ccagataaag aattcagggc                                                   20


<210> 23531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23531
attgccagat aaagaattca                                                   20


<210> 23532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23532
aattgccaga taaagaattc                                                   20


<210> 23533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23533
gaattgccag ataaagaatt                                                   20


<210> 23534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23534
aatctctgaa ttgccagata                                                   20


<210> 23535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23535
agaagaaatc tctgaattgc                                                   20


<210> 23536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23536
aacaatggat ccaaactaag                                                   20


<210> 23537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23537
cccaacaatg gatccaaact                                                   20


<210> 23538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23538
tcaaactagc tccccaacaa                                                   20


<210> 23539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23539
cacccctcaa aagatcaaac                                                   20


<210> 23540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23540
ggttcaataa cacccctcaa                                                   20


<210> 23541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23541
tctggtaata tgacaaaaga                                                   20


<210> 23542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23542
ttctggtaat atgacaaaag                                                   20


<210> 23543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23543
attctggtaa tatgacaaaa                                                   20


<210> 23544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23544
caattctggt aatatgacaa                                                   20


<210> 23545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23545
aggaaccaga aaagcaattc                                                   20


<210> 23546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23546
caaatgagaa ggaaccagaa                                                   20


<210> 23547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23547
ctactcaaat gagaaggaac                                                   20


<210> 23548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23548
aatagtctac tcaaatgaga                                                   20


<210> 23549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23549
aaatagtcta ctcaaatgag                                                   20


<210> 23550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23550
ctgaaatagt ctactcaaat                                                   20


<210> 23551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23551
tccagatctt ttctctgaaa                                                   20


<210> 23552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23552
gcacaacagc cattcagttc                                                   20


<210> 23553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23553
gaatctgcac aacagccatt                                                   20


<210> 23554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23554
aaacaaaaga atctgcacaa                                                   20


<210> 23555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23555
agagatcacc catgaaacaa                                                   20


<210> 23556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23556
tggggagagc accacatcaa                                                   20


<210> 23557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23557
attggggaga gcaccacatc                                                   20


<210> 23558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23558
catccccagg ggattgggga                                                   20


<210> 23559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23559
cccatcccca ggggattggg                                                   20


<210> 23560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23560
gccccatccc caggggattg                                                   20


<210> 23561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23561
agccccatcc ccaggggatt                                                   20


<210> 23562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23562
aagccccatc cccaggggat                                                   20


<210> 23563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23563
tcaggaagcc ccatccccag                                                   20


<210> 23564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23564
ctcaggaagc cccatcccca                                                   20


<210> 23565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23565
tctcaggaag ccccatcccc                                                   20


<210> 23566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23566
ctctcaggaa gccccatccc                                                   20


<210> 23567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23567
actgcagtcc agctctcagg                                                   20


<210> 23568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23568
atcactgcag tccagctctc                                                   20


<210> 23569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23569
gatcactgca gtccagctct                                                   20


<210> 23570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23570
caataacgat cactgcagtc                                                   20


<210> 23571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23571
aagaacaata acgatcactg                                                   20


<210> 23572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23572
ctctgtgtgg ctaggcccag                                                   20


<210> 23573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23573
cccctctgtg tggctaggcc                                                   20


<210> 23574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23574
ggtagcccct ctgtgtggct                                                   20


<210> 23575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23575
tggtagcccc tctgtgtggc                                                   20


<210> 23576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23576
agcctggtag cccctctgtg                                                   20


<210> 23577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23577
agtactaccc cagagcctgg                                                   20


<210> 23578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23578
cccagtacta ccccagagcc                                                   20


<210> 23579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23579
catttcccag tactacccca                                                   20


<210> 23580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23580
ggcatttccc agtactaccc                                                   20


<210> 23581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23581
ggactcttgc aggcatttcc                                                   20


<210> 23582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23582
tcacatcaca ggactcttgc                                                   20


<210> 23583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23583
atcacatcac aggactcttg                                                   20


<210> 23584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23584
ttcaagatca atcacatcac                                                   20


<210> 23585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23585
cttcaagatc aatcacatca                                                   20


<210> 23586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23586
atccatggct gggagacttc                                                   20


<210> 23587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23587
atgctgatat ccatggctgg                                                   20


<210> 23588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23588
agatgctgat atccatggct                                                   20


<210> 23589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23589
cagatgctga tatccatggc                                                   20


<210> 23590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23590
agaacagatg ctgatatcca                                                   20


<210> 23591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23591
ctctgccacc ttcaccagaa                                                   20


<210> 23592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23592
cattcctctg ccaccttcac                                                   20


<210> 23593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23593
tctacagcct aggactctca                                                   20


<210> 23594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23594
actaaatcta tctacagcct                                                   20


<210> 23595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23595
cactaaatct atctacagcc                                                   20


<210> 23596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23596
cagcacacta aatctatcta                                                   20


<210> 23597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23597
taactagcat tcaagaaagc                                                   20


<210> 23598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23598
aacataacta gcattcaaga                                                   20


<210> 23599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23599
tgctaacata actagcattc                                                   20


<210> 23600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23600
aacttcactg ctaacataac                                                   20


<210> 23601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23601
cctggctaac cagacgtcct                                                   20


<210> 23602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23602
cctgcaacat cctggctaac                                                   20


<210> 23603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23603
ttgcactgcc tgcaacatcc                                                   20


<210> 23604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23604
aggaaaaaga aaacaacaac                                                   20


<210> 23605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23605
ataactttga tcccaggaaa                                                   20


<210> 23606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23606
gacagaataa ctttgatccc                                                   20


<210> 23607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23607
tgacagaata actttgatcc                                                   20


<210> 23608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23608
gccattaaag caactcatga                                                   20


<210> 23609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23609
tcaaacagct caggccatta                                                   20


<210> 23610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23610
ggctggaggt caaacagctc                                                   20


<210> 23611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23611
cggctggagg tcaaacagct                                                   20


<210> 23612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23612
cctaccggct ggaggtcaaa                                                   20


<210> 23613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23613
aagcatcacc taccggctgg                                                   20


<210> 23614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23614
aaagcatcac ctaccggctg                                                   20


<210> 23615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23615
tgaaagcatc acctaccggc                                                   20


<210> 23616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 23616
ctcttgaaag catcacctac                                                   20


<210> 23617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23617
atgcactagt gctctcttga                                                   20


<210> 23618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23618
tcccccttct actaatgcac                                                   20


<210> 23619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23619
tggccaactt agggtgagct                                                   20


<210> 23620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23620
taccctggcc aacttagggt                                                   20


<210> 23621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23621
tatttaccct ggccaactta                                                   20


<210> 23622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23622
atatttaccc tggccaactt                                                   20


<210> 23623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23623
aatatttacc ctggccaact                                                   20


<210> 23624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23624
agaaactaaa atatttaccc                                                   20


<210> 23625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23625
tatggccctg ctcatcacct                                                   20


<210> 23626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23626
agaaactctc ggaagcttta                                                   20


<210> 23627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23627
caaaacccag aaactctcgg                                                   20


<210> 23628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 23628
acacaaaacc cagaaactct                                                   20


<210> 23629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23629
tggtagctga acacaaaacc                                                   20


<210> 23630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23630
tatttcccta cctgccttgg                                                   20


<210> 23631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23631
tggtatttcc ctacctgcct                                                   20


<210> 23632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23632
ctacccctgc ccccacctga                                                   20


<210> 23633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23633
acccaagaag ggtctgagtc                                                   20


<210> 23634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23634
tccctaccca agaagggtct                                                   20


<210> 23635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23635
cagcaatccc tacccaagaa                                                   20


<210> 23636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23636
acagcaatcc ctacccaaga                                                   20


<210> 23637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23637
cacagcaatc cctacccaag                                                   20


<210> 23638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23638
ggccacagca atccctaccc                                                   20


<210> 23639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23639
cccatccacc acagtggcca                                                   20


<210> 23640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23640
ccaaccccca tccaccacag                                                   20


<210> 23641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23641
gaaccaaccc ccatccacca                                                   20


<210> 23642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23642
gaacacaacc ccactggcct                                                   20


<210> 23643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23643
cctctggaac acaaccccac                                                   20


<210> 23644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23644
gaggcagcca aaattccctc                                                   20


<210> 23645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23645
actctatggc acagcagagg                                                   20


<210> 23646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23646
agaactctat ggcacagcag                                                   20


<210> 23647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23647
gagaactcta tggcacagca                                                   20


<210> 23648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23648
tggagaactc tatggcacag                                                   20


<210> 23649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23649
ccctggagaa ctctatggca                                                   20


<210> 23650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23650
cacttccctg gagaactcta                                                   20


<210> 23651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23651
agctatcccc cacttccctg                                                   20


<210> 23652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23652
gcagctatcc cccacttccc                                                   20


<210> 23653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23653
taggtgaggc ctctcactag                                                   20


<210> 23654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23654
agctaggtga ggcctctcac                                                   20


<210> 23655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23655
aactacatga gagctaggtg                                                   20


<210> 23656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23656
caactacatg agagctaggt                                                   20


<210> 23657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23657
tcaccaacta catgagagct                                                   20


<210> 23658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23658
ctcaccaact acatgagagc                                                   20


<210> 23659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23659
cagcctcacc aactacatga                                                   20


<210> 23660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23660
accagcctca ccaactacat                                                   20


<210> 23661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23661
gggcactgca ggagcaagac                                                   20


<210> 23662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23662
gagtagggca ctgcaggagc                                                   20


<210> 23663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23663
gtctgagtag ggcactgcag                                                   20


<210> 23664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23664
aggtctgagt agggcactgc                                                   20


<210> 23665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23665
aaggtctgag tagggcactg                                                   20


<210> 23666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23666
cctggggcaa ggtctgagta                                                   20


<210> 23667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23667
gcctggggca aggtctgagt                                                   20


<210> 23668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23668
agcctggggc aaggtctgag                                                   20


<210> 23669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23669
cacagcctgg ggcaaggtct                                                   20


<210> 23670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23670
gaagctcaca gcctggggca                                                   20


<210> 23671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23671
ggaagctcac agcctggggc                                                   20


<210> 23672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23672
gtggggaagc tcacagcctg                                                   20


<210> 23673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23673
agtggggaag ctcacagcct                                                   20


<210> 23674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23674
cagtggggaa gctcacagcc                                                   20


<210> 23675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23675
tttctcagtg gggaagctca                                                   20


<210> 23676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23676
tgctttcttt ctcagtgggg                                                   20


<210> 23677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23677
tcatgctttc tttctcagtg                                                   20


<210> 23678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23678
gtcatgcttt ctttctcagt                                                   20


<210> 23679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23679
agtcatgctt tctttctcag                                                   20


<210> 23680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23680
aaaagtcatg ctttctttct                                                   20


<210> 23681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23681
cagtgaggga tgcggtccaa                                                   20


<210> 23682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 23682
caagcagaca gtgagggatg                                                   20


<210> 23683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23683
gaactgcaag cagacagtga                                                   20


<210> 23684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23684
ggaactgcaa gcagacagtg                                                   20


<210> 23685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23685
gggaactgca agcagacagt                                                   20


<210> 23686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23686
aaatgggaac tgcaagcaga                                                   20


<210> 23687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23687
gggcaaatgg gaactgcaag                                                   20


<210> 23688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23688
agggggcaaa tgggaactgc                                                   20


<210> 23689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23689
gcagaatcca gggggcaaat                                                   20


<210> 23690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23690
agcagaatcc agggggcaaa                                                   20


<210> 23691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23691
tttcttgagc agaatccagg                                                   20


<210> 23692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23692
ttttcttgag cagaatccag                                                   20


<210> 23693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23693
attttcttga gcagaatcca                                                   20


<210> 23694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23694
aattttcttg agcagaatcc                                                   20


<210> 23695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23695
aaattttctt gagcagaatc                                                   20


<210> 23696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23696
tgggcacaaa ttttcttgag                                                   20


<210> 23697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23697
aactgggcac aaattttctt                                                   20


<210> 23698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23698
aattagtaat aatttcaact                                                   20


<210> 23699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23699
aaattagtaa taatttcaac                                                   20


<210> 23700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23700
aaagaagttt caactaaaat                                                   20


<210> 23701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23701
gaggggtcac aggatgaaag                                                   20


<210> 23702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23702
agggaggggt cacaggatga                                                   20


<210> 23703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23703
tggaatcagg gaggggtcac                                                   20


<210> 23704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23704
gtggaatcag ggaggggtca                                                   20


<210> 23705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23705
cagccagtgg aatcagggag                                                   20


<210> 23706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23706
gcagccagtg gaatcaggga                                                   20


<210> 23707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23707
ggcagccagt ggaatcaggg                                                   20


<210> 23708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23708
aggcagccag tggaatcagg                                                   20


<210> 23709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23709
gaaggcagcc agtggaatca                                                   20


<210> 23710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23710
ggaaggcagc cagtggaatc                                                   20


<210> 23711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23711
gggaaggcag ccagtggaat                                                   20


<210> 23712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23712
cccttgggga aggcagccag                                                   20


<210> 23713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23713
gcacccttgg ggaaggcagc                                                   20


<210> 23714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23714
acaggcaccc ttggggaagg                                                   20


<210> 23715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23715
ctcacaggca cccttgggga                                                   20


<210> 23716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23716
tctcacaggc acccttgggg                                                   20


<210> 23717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23717
atgtctcaca ggcacccttg                                                   20


<210> 23718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23718
tatgtctcac aggcaccctt                                                   20


<210> 23719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23719
ctatgtctca caggcaccct                                                   20


<210> 23720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23720
catccctgac tatgtctcac                                                   20


<210> 23721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23721
ccatccctga ctatgtctca                                                   20


<210> 23722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23722
cagtctccag cttgagacca                                                   20


<210> 23723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23723
ccagtctcca gcttgagacc                                                   20


<210> 23724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23724
cccagtctcc agcttgagac                                                   20


<210> 23725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23725
gcactcccag tctccagctt                                                   20


<210> 23726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23726
ttgtaggcac tcccagtctc                                                   20


<210> 23727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23727
aagtgccttg taggcactcc                                                   20


<210> 23728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23728
agcaaaggga agtgccttgt                                                   20


<210> 23729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23729
cagcaaaggg aagtgccttg                                                   20


<210> 23730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23730
aaagtagaaa cagcaaaggg                                                   20


<210> 23731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23731
ataaaagtag aaacagcaaa                                                   20


<210> 23732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23732
tataaaagta gaaacagcaa                                                   20


<210> 23733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23733
atataaaagt agaaacagca                                                   20


<210> 23734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23734
acaaaatata aaagtagaaa                                                   20


<210> 23735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23735
agccacacaa aatataaaag                                                   20


<210> 23736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23736
ggaagccaca caaaatataa                                                   20


<210> 23737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23737
ggaatgtaaa taaatttagg                                                   20


<210> 23738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23738
cctggaatgt aaataaattt                                                   20


<210> 23739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23739
acctggaatg taaataaatt                                                   20


<210> 23740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23740
gagaagaatt tacccttacc                                                   20


<210> 23741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23741
gaaaatccag atcacaggag                                                   20


<210> 23742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23742
tctgaaaatc cagatcacag                                                   20


<210> 23743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23743
aatctgaaaa tccagatcac                                                   20


<210> 23744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23744
taatctgaaa atccagatca                                                   20


<210> 23745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23745
aactgggtaa tctgaaaatc                                                   20


<210> 23746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23746
tccaaacata catcccaact                                                   20


<210> 23747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23747
ctccaaacat acatcccaac                                                   20


<210> 23748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23748
agctcccaaa gtgtgagggg                                                   20


<210> 23749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23749
gagctcccaa agtgtgaggg                                                   20


<210> 23750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23750
tgagctccca aagtgtgagg                                                   20


<210> 23751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23751
gtgagctccc aaagtgtgag                                                   20


<210> 23752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23752
tgtgagctcc caaagtgtga                                                   20


<210> 23753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23753
ctgtgagctc ccaaagtgtg                                                   20


<210> 23754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23754
actgtgagct cccaaagtgt                                                   20


<210> 23755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23755
tgaaaaactg tgagctccca                                                   20


<210> 23756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23756
caagacaggt gaaaaactgt                                                   20


<210> 23757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23757
tgctggaaat tctgcaagac                                                   20


<210> 23758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23758
ctgctggaaa ttctgcaaga                                                   20


<210> 23759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23759
cacactgctg gaaattctgc                                                   20


<210> 23760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23760
ttaaataagt ggcacactgc                                                   20


<210> 23761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23761
catagatcct tttaaataag                                                   20


<210> 23762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23762
attcatagat ccttttaaat                                                   20


<210> 23763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23763
aggagaactg aaagaattca                                                   20


<210> 23764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23764
gaatatacca ggagaactga                                                   20


<210> 23765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23765
ccactgcagg aatataccag                                                   20


<210> 23766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23766
aaccactgca ggaatatacc                                                   20


<210> 23767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23767
gaaccactgc aggaatatac                                                   20


<210> 23768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23768
tttgctccaa gaaccactgc                                                   20


<210> 23769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23769
gtttgctcca agaaccactg                                                   20


<210> 23770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23770
acaccatgaa cgtttgctcc                                                   20


<210> 23771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23771
tcccacttgg acagagtgtg                                                   20


<210> 23772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23772
ggtcccactt ggacagagtg                                                   20


<210> 23773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23773
atgcaggtcc cacttggaca                                                   20


<210> 23774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23774
acatgcaggt cccacttgga                                                   20


<210> 23775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23775
gctaacatgc aggtcccact                                                   20


<210> 23776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23776
aggagacagg gctaacatgc                                                   20


<210> 23777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23777
taggagacag ggctaacatg                                                   20


<210> 23778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23778
aaaatggtgg gtaggagaca                                                   20


<210> 23779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23779
caaaatggtg ggtaggagac                                                   20


<210> 23780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23780
acaaaatggt gggtaggaga                                                   20


<210> 23781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23781
ggggacaaaa tggtgggtag                                                   20


<210> 23782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23782
gaggggacaa aatggtgggt                                                   20


<210> 23783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23783
agaggggaca aaatggtggg                                                   20


<210> 23784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23784
aggagagggg acaaaatggt                                                   20


<210> 23785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23785
taggagaggg gacaaaatgg                                                   20


<210> 23786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23786
tgataggaga ggggacaaaa                                                   20


<210> 23787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23787
ctgcatgtgt gataggagag                                                   20


<210> 23788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23788
tctgcatgtg tgataggaga                                                   20


<210> 23789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23789
atctgcatgt gtgataggag                                                   20


<210> 23790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23790
gatctgcatg tgtgatagga                                                   20


<210> 23791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23791
cagatctgca tgtgtgatag                                                   20


<210> 23792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23792
tgcagatctg catgtgtgat                                                   20


<210> 23793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23793
atgcagatct gcatgtgtga                                                   20


<210> 23794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23794
ggcgtgagta tatctctatg                                                   20


<210> 23795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23795
tagcgtcatt accctggcgt                                                   20


<210> 23796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23796
ggattttagc gtcattaccc                                                   20


<210> 23797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23797
ccttggaact ggctggattt                                                   20


<210> 23798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23798
gagagatcct tggaactggc                                                   20


<210> 23799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23799
acctgagaga tccttggaac                                                   20


<210> 23800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23800
tcacgtacct gagagatcct                                                   20


<210> 23801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23801
aaatgagttc acgtacctga                                                   20


<210> 23802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23802
ctaaatgagt tcacgtacct                                                   20


<210> 23803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23803
caagaggatt ttgtctaaat                                                   20


<210> 23804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23804
ttgataaaga tactggcaag                                                   20


<210> 23805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23805
cttgataaag atactggcaa                                                   20


<210> 23806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23806
gccttgataa agatactggc                                                   20


<210> 23807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23807
tgaagccttg ataaagatac                                                   20


<210> 23808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23808
acacctttga agccttgata                                                   20


<210> 23809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23809
cactgtcatt tacacctttg                                                   20


<210> 23810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23810
tccttttcta ccctccttcc                                                   20


<210> 23811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23811
cctgagtaca ctccatggca                                                   20


<210> 23812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23812
aaccccctga gtacactcca                                                   20


<210> 23813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23813
cctggaagaa ggaaccccct                                                   20


<210> 23814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23814
catccctccc tcctggaaga                                                   20


<210> 23815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23815
tcatccctcc ctcctggaag                                                   20


<210> 23816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23816
aggtcatccc tccctcctgg                                                   20


<210> 23817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23817
agcaggtcat ccctccctcc                                                   20


<210> 23818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23818
tttcttggag cagtcagagc                                                   20


<210> 23819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23819
ttttcttgga gcagtcagag                                                   20


<210> 23820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23820
gttttttctt ggagcagtca                                                   20


<210> 23821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23821
atgttttttc ttggagcagt                                                   20


<210> 23822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23822
ttgcatgttt tttcttggag                                                   20


<210> 23823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23823
tctttgcatg ttttttcttg                                                   20


<210> 23824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23824
attctttgca tgttttttct                                                   20


<210> 23825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23825
cttcttcccc ctcatcacct                                                   20


<210> 23826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23826
tgtggccctt ctttttccct                                                   20


<210> 23827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23827
ccccactcca tctatttgtg                                                   20


<210> 23828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23828
gcagaagctg ctggctgtcc                                                   20


<210> 23829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23829
cccagaacag cagaagctgc                                                   20


<210> 23830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23830
gcctaacccc agaacagcag                                                   20


<210> 23831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23831
tctgcctaac cccagaacag                                                   20


<210> 23832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23832
ccctctgcct aaccccagaa                                                   20


<210> 23833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23833
tactgccctc tgcctaaccc                                                   20


<210> 23834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23834
gccctggcag acataaacag                                                   20


<210> 23835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23835
aggccctggc agacataaac                                                   20


<210> 23836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23836
gaggccctgg cagacataaa                                                   20


<210> 23837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23837
gcaggatagg gaggccctgg                                                   20


<210> 23838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23838
cttgcaggat agggaggccc                                                   20


<210> 23839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23839
cagcttcttg caggataggg                                                   20


<210> 23840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23840
ccagcttctt gcaggatagg                                                   20


<210> 23841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23841
ctccagcttc ttgcaggata                                                   20


<210> 23842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23842
cctccagctt cttgcaggat                                                   20


<210> 23843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23843
gcctccagct tcttgcagga                                                   20


<210> 23844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23844
atgagcctcc agcttcttgc                                                   20


<210> 23845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23845
gatgagcctc cagcttcttg                                                   20


<210> 23846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23846
ggagttttta gatgagcctc                                                   20


<210> 23847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23847
aaaactggga gtttttagat                                                   20


<210> 23848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23848
ttctaaaaac tgggagtttt                                                   20


<210> 23849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23849
ctccagtttc taaaaactgg                                                   20


<210> 23850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23850
cactccagtt tctaaaaact                                                   20


<210> 23851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23851
gcactccagt ttctaaaaac                                                   20


<210> 23852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23852
ccactcatca gtctgcactc                                                   20


<210> 23853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23853
ctctgtcagt taccactcat                                                   20


<210> 23854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23854
ctttcttagg tctgctctgt                                                   20


<210> 23855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23855
agccagtttt cagctttctt                                                   20


<210> 23856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23856
cagccagttt tcagctttct                                                   20


<210> 23857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23857
tccctgcttc agccagtttt                                                   20


<210> 23858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23858
tgggtattcc ctgcttcagc                                                   20


<210> 23859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23859
cttctgggta ttccctgctt                                                   20


<210> 23860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23860
gcatagcttg gcttgcttct                                                   20


<210> 23861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23861
agcatagctt ggcttgcttc                                                   20


<210> 23862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23862
tggggctctg cagcatagct                                                   20


<210> 23863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23863
agttctgggg ctctgcagca                                                   20


<210> 23864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23864
caagcagttc tggggctctg                                                   20


<210> 23865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23865
ctaagttcca agcagttctg                                                   20


<210> 23866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23866
tctaagttcc aagcagttct                                                   20


<210> 23867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23867
ctctaagttc caagcagttc                                                   20


<210> 23868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23868
tagcatctct aagttccaag                                                   20


<210> 23869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23869
acttagcatc tctaagttcc                                                   20


<210> 23870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23870
cagagatact tagcatctct                                                   20


<210> 23871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23871
accttgcttt cagagatact                                                   20


<210> 23872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23872
tcccccaaac cttgctttca                                                   20


<210> 23873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23873
cctcccccaa accttgcttt                                                   20


<210> 23874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23874
aaactttcaa gcaattcttt                                                   20


<210> 23875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23875
ggttcctgta aaaaactttc                                                   20


<210> 23876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23876
cagcatctag aaagctcaac                                                   20


<210> 23877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23877
ggcataaagc agcatctaga                                                   20


<210> 23878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23878
ggatggcata aagcagcatc                                                   20


<210> 23879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23879
attgaatgga tggcataaag                                                   20


<210> 23880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23880
ctcattgaat ggatggcata                                                   20


<210> 23881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23881
acagtttctc attgaatgga                                                   20


<210> 23882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23882
agaaacagtt tctcattgaa                                                   20


<210> 23883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23883
atccatttct ggagcagaaa                                                   20


<210> 23884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23884
catccaatcc atttctggag                                                   20


<210> 23885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23885
gagcatccaa tccatttctg                                                   20


<210> 23886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23886
atgagcatcc aatccatttc                                                   20


<210> 23887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23887
tcttcaactc ttaagaaaat                                                   20


<210> 23888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23888
ttccctcttc ttcaactctt                                                   20


<210> 23889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23889
ttttctttat atgcattttt                                                   20


<210> 23890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23890
ggagttgttt gcctttcagt                                                   20


<210> 23891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23891
gggagttgtt tgcctttcag                                                   20


<210> 23892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23892
gaggggagtt gtttgccttt                                                   20


<210> 23893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23893
gcagaagtga atagggaggg                                                   20


<210> 23894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23894
gagcagaagt gaatagggag                                                   20


<210> 23895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23895
ggagcagaag tgaataggga                                                   20


<210> 23896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23896
aggagcagaa gtgaataggg                                                   20


<210> 23897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23897
gaggagcaga agtgaatagg                                                   20


<210> 23898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23898
acgaggagca gaagtgaata                                                   20


<210> 23899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23899
aacgaggagc agaagtgaat                                                   20


<210> 23900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23900
taacgaggag cagaagtgaa                                                   20


<210> 23901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23901
ggaaacttaa cgaggagcag                                                   20


<210> 23902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23902
tctggaaact taacgaggag                                                   20


<210> 23903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23903
tcttctggaa acttaacgag                                                   20


<210> 23904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23904
tatcttctgg aaacttaacg                                                   20


<210> 23905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23905
ttatcttctg gaaacttaac                                                   20


<210> 23906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23906
ctctaaacca gattatcttc                                                   20


<210> 23907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23907
catcttcatg ggctctaaac                                                   20


<210> 23908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23908
taaaagtgca gcatcttcat                                                   20


<210> 23909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23909
ttaaaagtgc agcatcttca                                                   20


<210> 23910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23910
ggctgttcat gttaaaagtg                                                   20


<210> 23911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23911
tggctggctg ttcatgttaa                                                   20


<210> 23912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23912
aattcctgat gctccttggc                                                   20


<210> 23913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23913
ttcaaattcc tgatgctcct                                                   20


<210> 23914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23914
gctttggttt ctggtgttag                                                   20


<210> 23915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23915
gttgctttgg tttctggtgt                                                   20


<210> 23916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23916
tgtttggttg ctttggtttc                                                   20


<210> 23917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23917
tttcagttgt ttggttgctt                                                   20


<210> 23918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23918
tttttttttt ttcagttgtt                                                   20


<210> 23919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23919
tttctttttt tttttttttt                                                   20


<210> 23920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23920
gccacagcgc ctggccaata                                                   20


<210> 23921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23921
caggcgtgag ccacagcgcc                                                   20


<210> 23922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23922
gcgattacag gcgtgagcca                                                   20


<210> 23923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23923
agtgctgcga ttacaggcgt                                                   20


<210> 23924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23924
tcccaaagtg ctgcgattac                                                   20


<210> 23925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23925
ctcccaaagt gctgcgatta                                                   20


<210> 23926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23926
ctgcccgcct cggcctccca                                                   20


<210> 23927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 23927
acctcgtaat ctgcccgcct                                                   20


<210> 23928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23928
tttcaccgcg ttagccagga                                                   20


<210> 23929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23929
ggggtttcac cgcgttagcc                                                   20


<210> 23930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23930
cggggtttca ccgcgttagc                                                   20


<210> 23931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23931
gagacggggt ttcaccgcgt                                                   20


<210> 23932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23932
ttgtattttt agtagagacg                                                   20


<210> 23933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23933
tttgtatttt tagtagagac                                                   20


<210> 23934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 23934
ttttgtattt ttagtagaga                                                   20


<210> 23935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23935
aattttttgt atttttagta                                                   20


<210> 23936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23936
ctaatttttt gtatttttag                                                   20


<210> 23937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23937
cggctaattt tttgtatttt                                                   20


<210> 23938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 23938
caggtgcccg ccaaggcgcc                                                   20


<210> 23939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23939
ggaactacag gtgcccgcca                                                   20


<210> 23940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23940
tggaactaca ggtgcccgcc                                                   20


<210> 23941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23941
tccggagtag ctggaactac                                                   20


<210> 23942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23942
ctccggagta gctggaacta                                                   20


<210> 23943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23943
gcctcagcct ccggagtagc                                                   20


<210> 23944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23944
tcccgcctca gcctccggag                                                   20


<210> 23945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23945
ttctcccgcc tcagcctccg                                                   20


<210> 23946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 23946
cattctcccg cctcagcctc                                                   20


<210> 23947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23947
ttcacgccat tctcccgcct                                                   20


<210> 23948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23948
cactgcaagc tccgcctccc                                                   20


<210> 23949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 23949
tcactgcaag ctccgcctcc                                                   20


<210> 23950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23950
acgcgatcta ggctcactgc                                                   20


<210> 23951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23951
ggagtgcagt gacgcgatct                                                   20


<210> 23952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23952
tggagtgcag tgacgcgatc                                                   20


<210> 23953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23953
ctgtcaccca gactggagtg                                                   20


<210> 23954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23954
ttgctctgtc acccagactg                                                   20


<210> 23955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23955
tcttgctctg tcacccagac                                                   20


<210> 23956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23956
cgaagtcttg ctctgtcacc                                                   20


<210> 23957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23957
ttgttgttgt tttggagacg                                                   20


<210> 23958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23958
ctgttgttgt tgttgttttg                                                   20


<210> 23959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23959
tgctgttgtt gttgttgttt                                                   20


<210> 23960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23960
ctctctaaaa atattagtac                                                   20


<210> 23961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23961
actctctaaa aatattagta                                                   20


<210> 23962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23962
tcttaactct ctaaaaatat                                                   20


<210> 23963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23963
ctgctcttgt tctatacgtg                                                   20


<210> 23964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23964
ttctgctctt gttctatacg                                                   20


<210> 23965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23965
aaattccatt ttgtctttga                                                   20


<210> 23966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23966
aaaattccat tttgtctttg                                                   20


<210> 23967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23967
ttatttacaa gtccgcctat                                                   20


<210> 23968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23968
atttccaaaa ctttatttac                                                   20


<210> 23969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 23969
ttttttgttc cacttcctgt                                                   20


<210> 23970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23970
tagtcaaaca atatacctcc                                                   20


<210> 23971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23971
tttctttcta gacctcctat                                                   20


<210> 23972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23972
attgtcttct aatttctttc                                                   20


<210> 23973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23973
tatttccctc ttaattttga                                                   20


<210> 23974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23974
ttatttccct cttaattttg                                                   20


<210> 23975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23975
ctagggaaag acttctgtat                                                   20


<210> 23976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23976
tttgacagtt tggctaggga                                                   20


<210> 23977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23977
cttctttgac agtttggcta                                                   20


<210> 23978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23978
ccttctttga cagtttggct                                                   20


<210> 23979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23979
accttctttg acagtttggc                                                   20


<210> 23980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23980
ttctaccttc tttgacagtt                                                   20


<210> 23981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23981
atatattcta ccttctttga                                                   20


<210> 23982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23982
aactaagaag tacatttccc                                                   20


<210> 23983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23983
ttattagaag ggtaactaag                                                   20


<210> 23984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23984
actttattag aagggtaact                                                   20


<210> 23985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23985
ttctagtaac tttattagaa                                                   20


<210> 23986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23986
cttctagtaa ctttattaga                                                   20


<210> 23987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23987
gcttctagta actttattag                                                   20


<210> 23988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23988
ccagcttcta gtaactttat                                                   20


<210> 23989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23989
ataccaccat gcccagcttc                                                   20


<210> 23990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23990
caggtacata ccaccatgcc                                                   20


<210> 23991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23991
tcccaagtag ttaggactac                                                   20


<210> 23992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 23992
ctcccaagta gttaggacta                                                   20


<210> 23993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 23993
cctcaacctc ccaagtagtt                                                   20


<210> 23994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23994
gcctcaacct cccaagtagt                                                   20


<210> 23995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 23995
tcctgcctca acctcccaag                                                   20


<210> 23996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23996
tcctcctgcc tcaacctccc                                                   20


<210> 23997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 23997
ggcctcaaac tcctgggttc                                                   20


<210> 23998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 23998
gctgttggcc tcaaactcct                                                   20


<210> 23999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 23999
ggctgttggc ctcaaactcc                                                   20


<210> 24000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24000
ctctatgctg cccaggctgt                                                   20


<210> 24001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24001
aaagtctctc tatgctgccc                                                   20


<210> 24002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24002
caaagtctct ctatgctgcc                                                   20


<210> 24003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24003
taacattttt ttttaagaca                                                   20


<210> 24004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24004
ctctagtaac attttttttt                                                   20


<210> 24005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24005
tttgaatgga gcatatcctc                                                   20


<210> 24006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24006
atatgtttct tgtttgaatg                                                   20


<210> 24007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24007
atatatgttt cttgtttgaa                                                   20


<210> 24008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24008
gattcctttt gcctcttccc                                                   20


<210> 24009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24009
tttcttcttc attctttttt                                                   20


<210> 24010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24010
tgatgcacag ctgttttcta                                                   20


<210> 24011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24011
cctgatgcac agctgttttc                                                   20


<210> 24012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24012
tgttttctag gcctgatgca                                                   20


<210> 24013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24013
ttctgaccta gatgttttct                                                   20


<210> 24014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24014
attctgacct agatgttttc                                                   20


<210> 24015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24015
tcttctgcct cattctgacc                                                   20


<210> 24016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24016
tcctatggga atcacagcta                                                   20


<210> 24017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24017
tttcctatgg gaatcacagc                                                   20


<210> 24018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24018
tttttttcct atgggaatca                                                   20


<210> 24019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24019
gtgtatcatt tttttcctat                                                   20


<210> 24020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24020
tgtgtatcat ttttttccta                                                   20


<210> 24021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24021
tcaatttatt tgcacacatc                                                   20


<210> 24022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24022
ttcaatttat ttgcacacat                                                   20


<210> 24023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24023
tttgttccca aactcttctc                                                   20


<210> 24024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24024
attttatttt tttgtttgct                                                   20


<210> 24025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24025
tgctttcctt ggagttaata                                                   20


<210> 24026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24026
ttgctttcct tggagttaat                                                   20


<210> 24027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24027
caatgttttt gctttccttg                                                   20


<210> 24028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24028
cacaatgttt ttgctttcct                                                   20


<210> 24029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24029
ctgtttacag ctgtgtcatg                                                   20


<210> 24030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24030
tgctaagtaa acactgttta                                                   20


<210> 24031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24031
tataattaca ttacattgct                                                   20


<210> 24032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24032
gtaatcttca gttagatcat                                                   20


<210> 24033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24033
gttatattgt aatcttcagt                                                   20


<210> 24034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24034
tacagttata ttgtaatctt                                                   20


<210> 24035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24035
tcaccctcat cttcctgtta                                                   20


<210> 24036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24036
ctattatgag aaaaaactta                                                   20


<210> 24037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24037
cctattatga gaaaaaactt                                                   20


<210> 24038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24038
atttattggc ttcctattat                                                   20


<210> 24039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24039
caatttctga tgttatttat                                                   20


<210> 24040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24040
tttccagagg ccaccacttt                                                   20


<210> 24041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24041
ttctcatctc ttctttccag                                                   20


<210> 24042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24042
tttctcatct cttctttcca                                                   20


<210> 24043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24043
tttttctcat ctcttctttc                                                   20


<210> 24044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24044
aaagattctg acaaaaaaaa                                                   20


<210> 24045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24045
aaaggtcaca gagttttata                                                   20


<210> 24046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24046
tcataattta aaaggtcaca                                                   20


<210> 24047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24047
gttcataatt taaaaggtca                                                   20


<210> 24048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24048
atatatgttc ataatttaaa                                                   20


<210> 24049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24049
catatatgtt cataatttaa                                                   20


<210> 24050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24050
cttgactttt acttttattt                                                   20


<210> 24051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24051
aaacacgatt tctcctctca                                                   20


<210> 24052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24052
agcagctatg caaccagata                                                   20


<210> 24053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24053
agctcaagca gctatgcaac                                                   20


<210> 24054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24054
atggaagctg acagctcaag                                                   20


<210> 24055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24055
gatatggaag ctgacagctc                                                   20


<210> 24056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24056
caacaagata tggaagctga                                                   20


<210> 24057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24057
gggaaaccaa caagatatgg                                                   20


<210> 24058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24058
ggggggaaac caacaagata                                                   20


<210> 24059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24059
agtgtggggg ggaaaccaac                                                   20


<210> 24060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24060
aaaacataaa gagtgtgggg                                                   20


<210> 24061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24061
gaaaacataa agagtgtggg                                                   20


<210> 24062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24062
agaaaacata aagagtgtgg                                                   20


<210> 24063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24063
tagaaaacat aaagagtgtg                                                   20


<210> 24064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24064
ttagaaaaca taaagagtgt                                                   20


<210> 24065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24065
tttagaaaac ataaagagtg                                                   20


<210> 24066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24066
tctaatttag aaaacataaa                                                   20


<210> 24067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24067
tttctaattt agaaaacata                                                   20


<210> 24068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24068
tgagttaaga ttttctaatt                                                   20


<210> 24069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24069
acaacctata attctgagtt                                                   20


<210> 24070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24070
tcccaacaac ctataattct                                                   20


<210> 24071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24071
caaaccagaa atatccatca                                                   20


<210> 24072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24072
ctgtgtttga tttgacaaac                                                   20


<210> 24073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24073
gcactctctc cataatttct                                                   20


<210> 24074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24074
agcactctct ccataatttc                                                   20


<210> 24075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24075
cactgaaaat agtctttaga                                                   20


<210> 24076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24076
agcactgaaa atagtcttta                                                   20


<210> 24077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24077
gaagcactga aaatagtctt                                                   20


<210> 24078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24078
ttctggtgaa gcactgaaaa                                                   20


<210> 24079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24079
ggggcacttg ccttctggtg                                                   20


<210> 24080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24080
gagctggggc acttgccttc                                                   20


<210> 24081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24081
cattagctgc tgttgagctg                                                   20


<210> 24082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24082
ccattagctg ctgttgagct                                                   20


<210> 24083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24083
tccattagct gctgttgagc                                                   20


<210> 24084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24084
caactccatt agctgctgtt                                                   20


<210> 24085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24085
aagagaggat gcaactccat                                                   20


<210> 24086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24086
agccaaatac caccaaagag                                                   20


<210> 24087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24087
gagccaaata ccaccaaaga                                                   20


<210> 24088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24088
cagagccaaa taccaccaaa                                                   20


<210> 24089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24089
tgcagagcca aataccacca                                                   20


<210> 24090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24090
acatcaagaa ataccttgca                                                   20


<210> 24091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24091
caacatcaag aaataccttg                                                   20


<210> 24092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24092
gaatgctgca acccaacatc                                                   20


<210> 24093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24093
cacttaggaa ataacacatt                                                   20


<210> 24094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24094
gcacttagga aataacacat                                                   20


<210> 24095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24095
attcaccaga aaaagcactt                                                   20


<210> 24096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24096
cattcaccag aaaaagcact                                                   20


<210> 24097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24097
ttttcttcat tcaccagaaa                                                   20


<210> 24098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24098
caatgatttt cttcattcac                                                   20


<210> 24099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24099
gtgcaagtgg ctcaacggct                                                   20


<210> 24100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 24100
cagtggtgca agtggctcaa                                                   20


<210> 24101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24101
tcagacatca gtggtgcaag                                                   20


<210> 24102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24102
caatcagaca tcagtggtgc                                                   20


<210> 24103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24103
ttgtaacaat cagacatcag                                                   20


<210> 24104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24104
gatttgtaac aatcagacat                                                   20


<210> 24105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24105
atatcgggat ttgtaacaat                                                   20


<210> 24106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24106
gttttcagag cctgaatatc                                                   20


<210> 24107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 24107
tgttttcaga gcctgaatat                                                   20


<210> 24108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24108
attatgaatc tttgttttca                                                   20


<210> 24109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24109
atattatgaa tctttgtttt                                                   20


<210> 24110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24110
gggtatctca gtgatccatt                                                   20


<210> 24111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24111
tgaatacaag ttgggtatct                                                   20


<210> 24112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24112
catttttatg aatacaagtt                                                   20


<210> 24113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24113
ccatttttat gaatacaagt                                                   20


<210> 24114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24114
attaccattt ttatgaatac                                                   20


<210> 24115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24115
tacacagagt tttaaaaata                                                   20


<210> 24116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24116
ttacacagag ttttaaaaat                                                   20


<210> 24117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24117
aaatgggaag ggcttacaca                                                   20


<210> 24118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24118
gcaaatggga agggcttaca                                                   20


<210> 24119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24119
ctttggctgg caaatgggaa                                                   20


<210> 24120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24120
gctttggctg gcaaatggga                                                   20


<210> 24121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24121
tgctttggct ggcaaatggg                                                   20


<210> 24122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24122
aattgctttg gctggcaaat                                                   20


<210> 24123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24123
gaattgcttt ggctggcaaa                                                   20


<210> 24124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24124
ccacactgaa ttgctttggc                                                   20


<210> 24125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24125
tctcccacac tgaattgctt                                                   20


<210> 24126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24126
aaatgaaaag tgagtaagag                                                   20


<210> 24127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24127
gaaatgaaaa gtgagtaaga                                                   20


<210> 24128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24128
ctgaaatgaa aagtgagtaa                                                   20


<210> 24129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24129
ggctgaaatg aaaagtgagt                                                   20


<210> 24130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24130
actgggctga aatgaaaagt                                                   20


<210> 24131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24131
gcctactggg ctgaaatgaa                                                   20


<210> 24132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24132
gtacatctct ttggcctact                                                   20


<210> 24133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24133
tgtacatctc tttggcctac                                                   20


<210> 24134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24134
tcacttagtg tacatctctt                                                   20


<210> 24135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24135
acaaactgat tgtggtcact                                                   20


<210> 24136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24136
ttgtgaatac aaactgattg                                                   20


<210> 24137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24137
tttgctgttg aggtacacag                                                   20


<210> 24138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24138
tgatttgctg ttgaggtaca                                                   20


<210> 24139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24139
cagattctga tttgctgttg                                                   20


<210> 24140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24140
ccagattctg atttgctgtt                                                   20


<210> 24141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24141
gggggtctgt aatatgcctc                                                   20


<210> 24142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24142
tattcacgga acgcagctgg                                                   20


<210> 24143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24143
ttattcacgg aacgcagctg                                                   20


<210> 24144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24144
cttattcacg gaacgcagct                                                   20


<210> 24145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24145
ccttattcac ggaacgcagc                                                   20


<210> 24146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24146
cataccttat tcacggaacg                                                   20


<210> 24147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 24147
gctagtgcat accttattca                                                   20


<210> 24148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24148
ctgctcccag atcccaatgc                                                   20


<210> 24149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24149
cagatagaag atgctgctcc                                                   20


<210> 24150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24150
aggtatcact atccagatag                                                   20


<210> 24151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24151
gaaaggtatc actatccaga                                                   20


<210> 24152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24152
caaggaaagg tatcactatc                                                   20


<210> 24153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24153
gccacatggt cagcaaggaa                                                   20


<210> 24154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24154
agccacatgg tcagcaagga                                                   20


<210> 24155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24155
ctccagccac atggtcagca                                                   20


<210> 24156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24156
actccagcca catggtcagc                                                   20


<210> 24157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24157
agaaactcca gccacatggt                                                   20


<210> 24158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24158
ttgaagaaac tccagccaca                                                   20


<210> 24159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24159
aattgccatt gaagaaactc                                                   20


<210> 24160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24160
aaggtgttaa attgccattg                                                   20


<210> 24161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24161
actttttttt aaaagaggaa                                                   20


<210> 24162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24162
aacttttttt taaaagagga                                                   20


<210> 24163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24163
ccaaaacttt tttttaaaag                                                   20


<210> 24164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24164
accaaaactt ttttttaaaa                                                   20


<210> 24165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24165
ttaccaaaac ttttttttaa                                                   20


<210> 24166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24166
gtacttaaaa atggtgaaag                                                   20


<210> 24167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24167
tgtgtactta aaaatggtga                                                   20


<210> 24168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24168
ctaaattgtg tacttaaaaa                                                   20


<210> 24169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24169
ttggaaacag atagtggtga                                                   20


<210> 24170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24170
aaaagtttgg aaacagatag                                                   20


<210> 24171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24171
taaaaaagtt tggaaacaga                                                   20


<210> 24172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24172
attataaaaa agtttggaaa                                                   20


<210> 24173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24173
ttcgggatta taaaaaagtt                                                   20


<210> 24174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24174
ttctgttcgg gattataaaa                                                   20


<210> 24175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24175
taatgggtac atttctgttc                                                   20


<210> 24176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 24176
ttaatgggta catttctgtt                                                   20


<210> 24177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24177
atggggagtt attatttaat                                                   20


<210> 24178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24178
aatggggagt tattatttaa                                                   20


<210> 24179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24179
tgccagagag ggggaatggg                                                   20


<210> 24180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24180
gttgccagag agggggaatg                                                   20


<210> 24181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24181
agttgccaga gagggggaat                                                   20


<210> 24182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24182
aagttgccag agagggggaa                                                   20


<210> 24183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24183
aatggaagtt gccagagagg                                                   20


<210> 24184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24184
gaatggaagt tgccagagag                                                   20


<210> 24185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24185
agaatggaag ttgccagaga                                                   20


<210> 24186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24186
tagaatggaa gttgccagag                                                   20


<210> 24187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24187
gtagaatgga agttgccaga                                                   20


<210> 24188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24188
aagtagaatg gaagttgcca                                                   20


<210> 24189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24189
gaaagtagaa tggaagttgc                                                   20


<210> 24190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24190
ggagacagaa agtagaatgg                                                   20


<210> 24191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24191
catggagaca gaaagtagaa                                                   20


<210> 24192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24192
aaattcatgg agacagaaag                                                   20


<210> 24193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24193
ggcaaattca tggagacaga                                                   20


<210> 24194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24194
aacaggcaaa ttcatggaga                                                   20


<210> 24195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24195
ctagaacagg caaattcatg                                                   20


<210> 24196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24196
acctagaaca ggcaaattca                                                   20


<210> 24197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24197
ctttagtagg tacctagaac                                                   20


<210> 24198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24198
cctttagtag gtacctagaa                                                   20


<210> 24199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24199
ttccaccttt agtaggtacc                                                   20


<210> 24200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24200
tgcatgattc cacctttagt                                                   20


<210> 24201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24201
ttgcatgatt ccacctttag                                                   20


<210> 24202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24202
atgttgcatg attccacctt                                                   20


<210> 24203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24203
gtaaaataac tcaaacgcaa                                                   20


<210> 24204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24204
cattgacaaa gcattgtgct                                                   20


<210> 24205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24205
tacatgccac aacattgaca                                                   20


<210> 24206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24206
attcagtttt aaaaatgaat                                                   20


<210> 24207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24207
gtaaacaatt gaatatcatt                                                   20


<210> 24208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24208
agatgaatgg ataaaaaatg                                                   20


<210> 24209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24209
tatgtccatc aacagatgaa                                                   20


<210> 24210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24210
tagccaaata tgtccatcaa                                                   20


<210> 24211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24211
tgtagcagcg ttattcacaa                                                   20


<210> 24212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24212
ttatgcacta atgtttgtag                                                   20


<210> 24213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24213
ggcttatgca ctaatgtttg                                                   20


<210> 24214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24214
acagacttta aaaggtatgt                                                   20


<210> 24215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24215
cctatgaaac agactttaaa                                                   20


<210> 24216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24216
acctatgaaa cagactttaa                                                   20


<210> 24217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24217
attagtttga acctatgaaa                                                   20


<210> 24218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24218
tctctggttt aattaaaaat                                                   20


<210> 24219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24219
attttaaaag aagagctctc                                                   20


<210> 24220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24220
tgaagctaat tttaaaagaa                                                   20


<210> 24221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24221
catgaagcta attttaaaag                                                   20


<210> 24222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24222
tatcatgaag ctaattttaa                                                   20


<210> 24223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24223
tttttgttct atttatcatg                                                   20


<210> 24224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24224
ctatatatat gggaaagact                                                   20


<210> 24225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24225
tcttcactat atatatggga                                                   20


<210> 24226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24226
catatcttca ctatatatat                                                   20


<210> 24227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24227
gcatatcttc actatatata                                                   20


<210> 24228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24228
actatgaata agtaagttgt                                                   20


<210> 24229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24229
gaacaaaact atgaataagt                                                   20


<210> 24230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24230
agttgaacaa aactatgaat                                                   20


<210> 24231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24231
cgagcagaca ttttatttta                                                   20


<210> 24232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24232
atgactgtta ggtatacgag                                                   20


<210> 24233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24233
tcaatgactg ttaggtatac                                                   20


<210> 24234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24234
atttaaagtc aatgactgtt                                                   20


<210> 24235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24235
catttaaagt caatgactgt                                                   20


<210> 24236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24236
tataatgtga ctggcattta                                                   20


<210> 24237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24237
tgcattcctt ataatgtgac                                                   20


<210> 24238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24238
tggtataatt ccttaattag                                                   20


<210> 24239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24239
aattggtata attccttaat                                                   20


<210> 24240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24240
gaagaaacaa gaaaaacaat                                                   20


<210> 24241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24241
attgtggttg gagaagaaac                                                   20


<210> 24242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24242
tacaaatatt gtggttggag                                                   20


<210> 24243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24243
aattacaaat attgtggttg                                                   20


<210> 24244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24244
tcaattacaa atattgtggt                                                   20


<210> 24245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24245
caaatcaatt acaaatattg                                                   20


<210> 24246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24246
ctgctggtaa gatacaaaac                                                   20


<210> 24247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24247
acaattgcac tcctgctggt                                                   20


<210> 24248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24248
aagcacaatt gcactcctgc                                                   20


<210> 24249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24249
ttcatcctca tatcaaaaat                                                   20


<210> 24250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24250
gagaagacaa caaaactata                                                   20


<210> 24251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24251
ttgagaagac aacaaaacta                                                   20


<210> 24252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24252
attttatgtt aaaggttgag                                                   20


<210> 24253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24253
aaaattttat gttaaaggtt                                                   20


<210> 24254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24254
ttgtgaaaat tttatgttaa                                                   20


<210> 24255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24255
attgtgaaaa ttttatgtta                                                   20


<210> 24256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24256
agcacaaaat aaggctttcc                                                   20


<210> 24257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24257
tctactacaa gcacaaaata                                                   20


<210> 24258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24258
ctctactaca agcacaaaat                                                   20


<210> 24259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24259
caattgaata tctctactac                                                   20


<210> 24260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24260
ttccatatta ttttccaata                                                   20


<210> 24261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24261
ttttgtcaag taatgatata                                                   20


<210> 24262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24262
tatctgctaa cgtttttgtc                                                   20


<210> 24263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24263
gaccaatgat ccttttgtcc                                                   20


<210> 24264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24264
taatgataat tgaattttat                                                   20


<210> 24265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24265
aaaaatatat aagaaaatgg                                                   20


<210> 24266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24266
acaaaaatat ataagaaaat                                                   20


<210> 24267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24267
gacaaaaata tataagaaaa                                                   20


<210> 24268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24268
aaaaccagac aaaaatatat                                                   20


<210> 24269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24269
tgtggataat ctcccaaaac                                                   20


<210> 24270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24270
agacaagtgg ataatggatg                                                   20


<210> 24271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24271
gtcatgagac aagtggataa                                                   20


<210> 24272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24272
tctgtttgtc atgagacaag                                                   20


<210> 24273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24273
gaatctgttt gtcatgagac                                                   20


<210> 24274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24274
agcatgaatc tgtttgtcat                                                   20


<210> 24275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24275
gcctccattg taaaaataca                                                   20


<210> 24276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24276
gtcacaatgt aagtaatgaa                                                   20


<210> 24277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24277
gtgaaataag gtcacaatgt                                                   20


<210> 24278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24278
aaatcctaca atgtgaaata                                                   20


<210> 24279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24279
taaatcctac aatgtgaaat                                                   20


<210> 24280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24280
cataacaata atgataaaaa                                                   20


<210> 24281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24281
acttcgaaag tggttttctg                                                   20


<210> 24282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24282
aagagtcatc acttcgaaag                                                   20


<210> 24283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24283
aaaaagagtc atcacttcga                                                   20


<210> 24284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24284
atatcacaat tcaaaaaaaa                                                   20


<210> 24285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24285
taatatcaca attcaaaaaa                                                   20


<210> 24286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24286
tgacagttat ttacacttgt                                                   20


<210> 24287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24287
tgtattttat tgtcacctga                                                   20


<210> 24288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24288
aacatggagt taatcatagg                                                   20


<210> 24289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24289
gttaacatgg agttaatcat                                                   20


<210> 24290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24290
ggttaacatg gagttaatca                                                   20


<210> 24291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24291
cattcataat ggttaacatg                                                   20


<210> 24292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24292
ttcattcata atggttaaca                                                   20


<210> 24293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24293
aaaactgatt tcattcataa                                                   20


<210> 24294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24294
actttttatg ttttcaaaaa                                                   20


<210> 24295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24295
aagattaatt attatattca                                                   20


<210> 24296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24296
aattttaaaa tctaacatgt                                                   20


<210> 24297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24297
gtttctcaac aagtgatcta                                                   20


<210> 24298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24298
tgtttctcaa caagtgatct                                                   20


<210> 24299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24299
ctcctacaat gtttctcaac                                                   20


<210> 24300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24300
tattcttact ttgtttagca                                                   20


<210> 24301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24301
cttattctta ctttgtttag                                                   20


<210> 24302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24302
caacttattc ttactttgtt                                                   20


<210> 24303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24303
ctctctcctc aattgtccct                                                   20


<210> 24304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24304
actctctcct caattgtccc                                                   20


<210> 24305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24305
ctttcataaa ctgtcccttt                                                   20


<210> 24306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24306
tctttcataa actgtccctt                                                   20


<210> 24307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24307
tctattttgc taaatgaggc                                                   20


<210> 24308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24308
tttatctatt ttgctaaatg                                                   20


<210> 24309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24309
ttttatctat tttgctaaat                                                   20


<210> 24310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24310
tcattttgct ggattcaatt                                                   20


<210> 24311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24311
atcattttgc tggattcaat                                                   20


<210> 24312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24312
gttccagctg atcattttgc                                                   20


<210> 24313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24313
tagtctattt ttaatggttc                                                   20


<210> 24314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24314
gtttgttagt ctatttttaa                                                   20


<210> 24315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24315
ctgtaaacta acaggtttgt                                                   20


<210> 24316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24316
tagtaaatct gtaaactaac                                                   20


<210> 24317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24317
atagtaaatc tgtaaactaa                                                   20


<210> 24318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24318
tagtctttca tctgttagta                                                   20


<210> 24319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24319
tcatatagtc tttcatctgt                                                   20


<210> 24320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24320
tatttattga ggttatcata                                                   20


<210> 24321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24321
cagtattttt atatttattg                                                   20


<210> 24322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24322
tcagtatttt tatatttatt                                                   20


<210> 24323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24323
gaatgggtgt tggcttctat                                                   20


<210> 24324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24324
ctttcatcat gaatgggtgt                                                   20


<210> 24325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24325
ttgagacttt catcatgaat                                                   20


<210> 24326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24326
gttgagactt tcatcatgaa                                                   20


<210> 24327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24327
ttttccattt cttgtttgtt                                                   20


<210> 24328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24328
cactattatg atgtttatga                                                   20


<210> 24329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24329
ttcactatta tgatgtttat                                                   20


<210> 24330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24330
ttattttgct cttgatttta                                                   20


<210> 24331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24331
taattcaaag ctatgacagt                                                   20


<210> 24332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24332
atggtaattc aaagctatga                                                   20


<210> 24333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24333
ttcaacaaga tggtaattca                                                   20


<210> 24334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24334
ggccgggacc ttcaacaaga                                                   20


<210> 24335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24335
aattggccgg gaccttcaac                                                   20


<210> 24336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24336
cctgtcttat tgaattggcc                                                   20


<210> 24337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 24337
tcctgtctta ttgaattggc                                                   20


<210> 24338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24338
tttttcctgt cttattgaat                                                   20


<210> 24339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24339
ccttggactt cctatttaga                                                   20


<210> 24340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24340
attcccttgg acttcctatt                                                   20


<210> 24341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24341
aatttttctg tagattccct                                                   20


<210> 24342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24342
cttaaagtta aatttttctg                                                   20


<210> 24343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24343
caaccctgct gagctcctta                                                   20


<210> 24344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24344
ttgcatccag caaccctgct                                                   20


<210> 24345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24345
ctatatagtg attttgcatc                                                   20


<210> 24346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24346
taatattatt aatttctata                                                   20


<210> 24347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24347
tcctaggtac attgcaattt                                                   20


<210> 24348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24348
ttttataatg tctttttcct                                                   20


<210> 24349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24349
attttataat gtctttttcc                                                   20


<210> 24350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24350
gcagatctct taatttatac                                                   20


<210> 24351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24351
ggcagatctc ttaatttata                                                   20


<210> 24352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24352
cttcccacac atcagtatgg                                                   20


<210> 24353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24353
agccttccca cacatcagta                                                   20


<210> 24354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24354
tacgaagcct tcccacacat                                                   20


<210> 24355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24355
atcgccacat ttacaatacg                                                   20


<210> 24356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24356
aattgattta tcaccacagg                                                   20


<210> 24357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24357
ctgaattgat ttatcaccac                                                   20


<210> 24358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24358
actgaattga tttatcacca                                                   20


<210> 24359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24359
aactctgtgg aaactttgtt                                                   20


<210> 24360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24360
gctcttttct tacaactctg                                                   20


<210> 24361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24361
agtttaaggg tcacattttc                                                   20


<210> 24362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24362
acttttccat atcagtttaa                                                   20


<210> 24363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24363
tacttttcca tatcagttta                                                   20


<210> 24364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24364
ttacttttcc atatcagttt                                                   20


<210> 24365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24365
gtttctttac ttttccatat                                                   20


<210> 24366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24366
tgtcttcttg aaaattattt                                                   20


<210> 24367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24367
ctctatagta agatttgacc                                                   20


<210> 24368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24368
ggatttaaat gctctatagt                                                   20


<210> 24369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24369
acgtggattt aaatgctcta                                                   20


<210> 24370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24370
catcctgagt caacaccacg                                                   20


<210> 24371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24371
taatctcatt gtcacatcct                                                   20


<210> 24372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24372
tctactgaat ctgtttctcc                                                   20


<210> 24373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24373
ccactgcttc tgccatgcac                                                   20


<210> 24374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24374
tcaatacatc atttcccaag                                                   20


<210> 24375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24375
ttttcaatac atcatttccc                                                   20


<210> 24376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24376
gcttccaata tttttccata                                                   20


<210> 24377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24377
gtatgtgtgt ggtatgagat                                                   20


<210> 24378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24378
tgtatgtgtg tggtatgaga                                                   20


<210> 24379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24379
tttttgtatg tgtgtggtat                                                   20


<210> 24380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24380
aatttatttt tgtatgtgtg                                                   20


<210> 24381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24381
atttaggtat ttcaatctcc                                                   20


<210> 24382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24382
cagttttcct ttctacattt                                                   20


<210> 24383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24383
acagttttcc tttctacatt                                                   20


<210> 24384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24384
gtgttttctc ctcaaagtta                                                   20


<210> 24385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24385
tatcctgtgt tttctcctca                                                   20


<210> 24386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24386
ttgccatata gtattccata                                                   20


<210> 24387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24387
attcattttt tattgccata                                                   20


<210> 24388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24388
tttgcccaaa tggatacatg                                                   20


<210> 24389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24389
gtttttggga tttgcccaaa                                                   20


<210> 24390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24390
tgttttaaaa ttatgttttt                                                   20


<210> 24391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24391
atgttttaaa attatgtttt                                                   20


<210> 24392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24392
tttgtatctt ttcaaattta                                                   20


<210> 24393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24393
tgtttaacac tgcatgcata                                                   20


<210> 24394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24394
tctactgcaa acggggaagt                                                   20


<210> 24395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24395
atctactgca aacggggaag                                                   20


<210> 24396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24396
tgaatctact gcaaacgggg                                                   20


<210> 24397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24397
agctgaatct actgcaaacg                                                   20


<210> 24398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24398
aagctgaatc tactgcaaac                                                   20


<210> 24399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 24399
gaagctgaat ctactgcaaa                                                   20


<210> 24400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24400
ggcaaagaac atgtgaaatg                                                   20


<210> 24401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24401
aaatgttttc tcacctggca                                                   20


<210> 24402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24402
aagataaatg ttttctcacc                                                   20


<210> 24403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24403
atagcaattt ggttgtagag                                                   20


<210> 24404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24404
attatagcaa tttggttgta                                                   20


<210> 24405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24405
aaattatagc aatttggttg                                                   20


<210> 24406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24406
tttgacaaat tatagcaatt                                                   20


<210> 24407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24407
ggaaaacctt tgacaaatta                                                   20


<210> 24408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24408
ctctaagcat aacaatattc                                                   20


<210> 24409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24409
accctaggac actcacctct                                                   20


<210> 24410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24410
aggggctctt tgatgaccct                                                   20


<210> 24411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24411
aaggggctct ttgatgaccc                                                   20


<210> 24412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24412
gtttcagaga atcattgaag                                                   20


<210> 24413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24413
ggtttcagag aatcattgaa                                                   20


<210> 24414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24414
tggtttcaga gaatcattga                                                   20


<210> 24415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24415
ctggtttcag agaatcattg                                                   20


<210> 24416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24416
ctccccatgc cctggtttca                                                   20


<210> 24417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24417
ctctccccat gccctggttt                                                   20


<210> 24418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24418
ttcctactct ccccatgccc                                                   20


<210> 24419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24419
attgttaaga agggcaagac                                                   20


<210> 24420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24420
caaaaattgt taagaagggc                                                   20


<210> 24421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24421
gggtcaaaaa ttgttaagaa                                                   20


<210> 24422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24422
ggggtcaaaa attgttaaga                                                   20


<210> 24423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24423
gggggtcaaa aattgttaag                                                   20


<210> 24424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24424
gcagggggtc aaaaattgtt                                                   20


<210> 24425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24425
cagaaggtaa agagagcagg                                                   20


<210> 24426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24426
ccagaaggta aagagagcag                                                   20


<210> 24427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24427
accagaaggt aaagagagca                                                   20


<210> 24428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24428
caccagaagg taaagagagc                                                   20


<210> 24429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24429
gcaccagaag gtaaagagag                                                   20


<210> 24430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24430
tgggcaccag aaggtaaaga                                                   20


<210> 24431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24431
attgggcacc agaaggtaaa                                                   20


<210> 24432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24432
agattgggca ccagaaggta                                                   20


<210> 24433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24433
tcctcagatt gggcaccaga                                                   20


<210> 24434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24434
ttcctcagat tgggcaccag                                                   20


<210> 24435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24435
ttcttcctca gattgggcac                                                   20


<210> 24436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24436
tagaggttct tcctcagatt                                                   20


<210> 24437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24437
ctagaggttc ttcctcagat                                                   20


<210> 24438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24438
agaaactaga ggttcttcct                                                   20


<210> 24439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24439
tttgcttggg aagaaactag                                                   20


<210> 24440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24440
ttttgcttgg gaagaaacta                                                   20


<210> 24441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24441
tcttttgctt gggaagaaac                                                   20


<210> 24442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24442
aatcccctct tttgcttggg                                                   20


<210> 24443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24443
tctaatcccc tcttttgctt                                                   20


<210> 24444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24444
ttctaatccc ctcttttgct                                                   20


<210> 24445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24445
tgcttgtgga aagataaaga                                                   20


<210> 24446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24446
tgtctgcttg tggaaagata                                                   20


<210> 24447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24447
cctatctgtc tgcttgtgga                                                   20


<210> 24448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24448
cctgcctatc tgtctgcttg                                                   20


<210> 24449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24449
caattacctg ctgataatgg                                                   20


<210> 24450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24450
gcacaattac ctgctgataa                                                   20


<210> 24451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24451
attattcctt gctgaaacat                                                   20


<210> 24452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24452
aattgtagcc agtgaggaat                                                   20


<210> 24453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24453
gcattaaatt gtagccagtg                                                   20


<210> 24454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24454
agcattaaat tgtagccagt                                                   20


<210> 24455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24455
aaaaagcatt aaattgtagc                                                   20


<210> 24456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24456
tttgaaaaag cattaaattg                                                   20


<210> 24457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24457
catgctgtat acttttgaaa                                                   20


<210> 24458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24458
tgggatagac tggggctcca                                                   20


<210> 24459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24459
aatgtccttg ggatagactg                                                   20


<210> 24460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24460
aaatgtcctt gggatagact                                                   20


<210> 24461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24461
taaatgtcct tgggatagac                                                   20


<210> 24462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24462
gataataaat gtccttggga                                                   20


<210> 24463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24463
ggaagataat aaatgtcctt                                                   20


<210> 24464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24464
aggaagataa taaatgtcct                                                   20


<210> 24465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24465
tgttgctgag aacccagagg                                                   20


<210> 24466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24466
ctatgttgct gagaacccag                                                   20


<210> 24467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24467
cctatgttgc tgagaaccca                                                   20


<210> 24468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24468
ttcctatgtt gctgagaacc                                                   20


<210> 24469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24469
tagttgtttc ctatgttgct                                                   20


<210> 24470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24470
tgcaaattga taatagccat                                                   20


<210> 24471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24471
tttgaaatgc aaattgataa                                                   20


<210> 24472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24472
cctcgtggaa ataatcagac                                                   20


<210> 24473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24473
cttggcctcg tggaaataat                                                   20


<210> 24474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24474
gttcagcatc cttggcctcg                                                   20


<210> 24475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24475
tggatgatgt tcagcatcct                                                   20


<210> 24476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24476
gacaggtatt ggatgatgtt                                                   20


<210> 24477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24477
ggaatttatg tgacaggtat                                                   20


<210> 24478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24478
atcctgggaa tttatgtgac                                                   20


<210> 24479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24479
aatcctggga atttatgtga                                                   20


<210> 24480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24480
acctatatgg tcacaatcct                                                   20


<210> 24481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24481
tacctatatg gtcacaatcc                                                   20


<210> 24482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24482
catatacaaa tctacctata                                                   20


<210> 24483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24483
ctttatatgc acactatgaa                                                   20


<210> 24484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24484
ttatcaaatc cattctttag                                                   20


<210> 24485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24485
aattatcaaa tccattcttt                                                   20


<210> 24486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24486
taattatcaa atccattctt                                                   20


<210> 24487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24487
agttggatcc tttccattcc                                                   20


<210> 24488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24488
gccaaatcgt cttccaaagt                                                   20


<210> 24489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24489
tattgccaaa tcgtcttcca                                                   20


<210> 24490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24490
gggtgtacat tttaattttt                                                   20


<210> 24491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24491
gtagaattgc caggtcaaag                                                   20


<210> 24492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24492
agtagaattg ccaggtcaaa                                                   20


<210> 24493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24493
aagtagaatt gccaggtcaa                                                   20


<210> 24494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24494
gaagtagaat tgccaggtca                                                   20


<210> 24495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24495
tttctagaag tagaattgcc                                                   20


<210> 24496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24496
atttctagaa gtagaattgc                                                   20


<210> 24497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24497
taaggatgaa tttctagaag                                                   20


<210> 24498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24498
aattaaggat gaatttctag                                                   20


<210> 24499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24499
taaaattaag gatgaatttc                                                   20


<210> 24500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24500
acataatatg agtaaaatta                                                   20


<210> 24501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24501
cacataatat gagtaaaatt                                                   20


<210> 24502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24502
tatctttgta cacataatat                                                   20


<210> 24503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24503
ccacatatta attttttggt                                                   20


<210> 24504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24504
gccaccacat attaattttt                                                   20


<210> 24505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24505
tttaactatt ttcctattga                                                   20


<210> 24506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24506
tcatttgcat ggatgaagtg                                                   20


<210> 24507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24507
agatttcatt tgcatggatg                                                   20


<210> 24508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24508
ctgaacagat ttcatttgca                                                   20


<210> 24509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24509
ttttatagaa attagctgaa                                                   20


<210> 24510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24510
agcagctgtt ttatagaaat                                                   20


<210> 24511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24511
tcccagcagc agctgtttta                                                   20


<210> 24512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24512
ccccaaaaaa atcccagcag                                                   20


<210> 24513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24513
catccccaaa aaaatcccag                                                   20


<210> 24514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24514
tgacatcccc aaaaaaatcc                                                   20


<210> 24515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24515
aatgtcagtg ctgcccaaat                                                   20


<210> 24516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24516
attcataatt gttagaatgt                                                   20


<210> 24517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24517
attagaagat tcataattgt                                                   20


<210> 24518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24518
gtctcatgtg actggattag                                                   20


<210> 24519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24519
gatgtctcat gtgactggat                                                   20


<210> 24520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24520
taaaggatgt ctcatgtgac                                                   20


<210> 24521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24521
aaagtaccta aatgaattaa                                                   20


<210> 24522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24522
taaagtacct aaatgaatta                                                   20


<210> 24523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24523
cattattgag agaaatttta                                                   20


<210> 24524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24524
aaataataca gcattattga                                                   20


<210> 24525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24525
aaaaataata cagcattatt                                                   20


<210> 24526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24526
ctttatacta aaaaataata                                                   20


<210> 24527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24527
gctgttgtaa aaatatgcac                                                   20


<210> 24528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24528
attacaaaat agaaaaacag                                                   20


<210> 24529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24529
taaattacaa aatagaaaaa                                                   20


<210> 24530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24530
aaaagcaata aattacaaaa                                                   20


<210> 24531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24531
aagaagttaa taattataaa                                                   20


<210> 24532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24532
ggataacaaa tgaaagaaag                                                   20


<210> 24533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24533
aaaggataac aaatgaaaga                                                   20


<210> 24534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24534
agaaaaagga taacaaatga                                                   20


<210> 24535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24535
gacctaacaa aactagaaaa                                                   20


<210> 24536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24536
agacctaaca aaactagaaa                                                   20


<210> 24537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24537
atttaaagac ctaacaaaac                                                   20


<210> 24538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24538
agctgaaaag aaattattta                                                   20


<210> 24539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24539
ttatatcagt aaaagctgaa                                                   20


<210> 24540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24540
tagaatattt atatcagtaa                                                   20


<210> 24541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24541
gaagcataga atatttatat                                                   20


<210> 24542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24542
taagtcacag catggaagca                                                   20


<210> 24543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24543
gggaataagt cacagcatgg                                                   20


<210> 24544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24544
tcagggaata agtcacagca                                                   20


<210> 24545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24545
catattcagg gaataagtca                                                   20


<210> 24546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24546
gacatacata ttcagggaat                                                   20


<210> 24547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24547
gttaaagaca tacatattca                                                   20


<210> 24548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24548
agttaaagac atacatattc                                                   20


<210> 24549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24549
cagttaaaga catacatatt                                                   20


<210> 24550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24550
gaacctagag agtgcagtta                                                   20


<210> 24551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24551
taatcagaac ctagagagtg                                                   20


<210> 24552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24552
cagtttaatc agaacctaga                                                   20


<210> 24553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24553
aacagtttaa tcagaaccta                                                   20


<210> 24554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24554
aaaacagttt aatcagaacc                                                   20


<210> 24555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24555
aagataaaaa acagtttaat                                                   20


<210> 24556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24556
agggaaggaa agataaaaaa                                                   20


<210> 24557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24557
atataatttc gagggaagga                                                   20


<210> 24558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24558
aattatataa tttcgaggga                                                   20


<210> 24559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24559
aaattatata atttcgaggg                                                   20


<210> 24560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24560
ctaaaattat ataatttcga                                                   20


<210> 24561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24561
actaaaatta tataatttcg                                                   20


<210> 24562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24562
aactaaaatt atataatttc                                                   20


<210> 24563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24563
cttaaagaat tcttggacaa                                                   20


<210> 24564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24564
aatctctctt aaagaattct                                                   20


<210> 24565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24565
atttttaaaa atctctctta                                                   20


<210> 24566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24566
accaaattta atgaaatgag                                                   20


<210> 24567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24567
aaccaaattt aatgaaatga                                                   20


<210> 24568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24568
ataaccaaat ttaatgaaat                                                   20


<210> 24569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24569
tctctgatca taatgaaata                                                   20


<210> 24570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24570
attctctgat cataatgaaa                                                   20


<210> 24571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24571
tccagaaagt ggaaataata                                                   20


<210> 24572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24572
cctcaataag ctccagaaag                                                   20


<210> 24573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24573
aaacctcaat aagctccaga                                                   20


<210> 24574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24574
acaaaaacct caataagctc                                                   20


<210> 24575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24575
gccatgacaa aaacctcaat                                                   20


<210> 24576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24576
aacatatcaa accaaatatt                                                   20


<210> 24577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24577
caaactacct tccctaacaa                                                   20


<210> 24578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24578
taatgtatct gattaatata                                                   20


<210> 24579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24579
atgtaaaatt atagatgacc                                                   20


<210> 24580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24580
ttaaaaagta tgtaaaatta                                                   20


<210> 24581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24581
aacagatcaa atgtattaaa                                                   20


<210> 24582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24582
caattaattt tagccaataa                                                   20


<210> 24583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24583
tagaaatttt caattaattt                                                   20


<210> 24584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24584
aaataaaaac attgtaggaa                                                   20


<210> 24585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24585
aggataaata aaaacattgt                                                   20


<210> 24586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24586
gaggataaat aaaaacattg                                                   20


<210> 24587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24587
tcagaaatta ttagagtagg                                                   20


<210> 24588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24588
atcagaaatt attagagtag                                                   20


<210> 24589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24589
aaatcagaaa ttattagagt                                                   20


<210> 24590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24590
taaatcagaa attattagag                                                   20


<210> 24591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24591
ttataaatca gaaattatta                                                   20


<210> 24592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24592
atttataaat cagaaattat                                                   20


<210> 24593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24593
tggcaacaat atttataaat                                                   20


<210> 24594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24594
tatctttgca acaaataaga                                                   20


<210> 24595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24595
tctatatctt tgcaacaaat                                                   20


<210> 24596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24596
catattaata ttaaagacga                                                   20


<210> 24597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24597
gcacagacat attaatatta                                                   20


<210> 24598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24598
gaaataggac aaaaattgca                                                   20


<210> 24599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24599
tcggtcaaaa agcatgaaat                                                   20


<210> 24600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24600
ctcggtcaaa aagcatgaaa                                                   20


<210> 24601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24601
aaagtggaat ctcggtcaaa                                                   20


<210> 24602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 24602
tatcagagaa agtggaatct                                                   20


<210> 24603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24603
gattttaata tcagagaaag                                                   20


<210> 24604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24604
catgatttta atatcagaga                                                   20


<210> 24605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24605
gatccatgat tttaatatca                                                   20


<210> 24606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24606
aggatccatg attttaatat                                                   20


<210> 24607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24607
caaaggcaaa caaagaaagc                                                   20


<210> 24608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24608
gcaaaggcaa acaaagaaag                                                   20


<210> 24609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24609
taagcaaagg caaacaaaga                                                   20


<210> 24610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24610
gacataagca aaggcaaaca                                                   20


<210> 24611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24611
aattcaaaag acataagcaa                                                   20


<210> 24612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24612
gaattcaaaa gacataagca                                                   20


<210> 24613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24613
ttatagaatt caaaagacat                                                   20


<210> 24614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24614
gctaaaatta tagaattcaa                                                   20


<210> 24615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24615
atacagaaag gctaaaatta                                                   20


<210> 24616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24616
ctcctcacgg tgatacagaa                                                   20


<210> 24617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24617
actcctcacg gtgatacaga                                                   20


<210> 24618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24618
aaatactcct cacggtgata                                                   20


<210> 24619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 24619
aataaaaaaa atactcctca                                                   20


<210> 24620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24620
aaaatgccta ttacattaca                                                   20


<210> 24621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24621
gtcatgtcac taaatataaa                                                   20


<210> 24622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24622
aatataaaca agctaagact                                                   20


<210> 24623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24623
tgaaataata taaacaagct                                                   20


<210> 24624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24624
tcatatgaaa taatataaac                                                   20


<210> 24625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 24625
gaatgtattc caatatcaaa                                                   20


<210> 24626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24626
taacatggtc acatttattt                                                   20


<210> 24627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24627
cattaaaatg atgtataaca                                                   20


<210> 24628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24628
tcattagcaa aaaaaaaagt                                                   20


<210> 24629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24629
taagtcatta gcaaaaaaaa                                                   20


<210> 24630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24630
aacagcaagt aataagtcat                                                   20


<210> 24631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24631
taaaataaac agcaagtaat                                                   20


<210> 24632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24632
ataaatataa aataaacagc                                                   20


<210> 24633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24633
taaaataaat ataaaataaa                                                   20


<210> 24634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24634
tttgtataac ataatttcca                                                   20


<210> 24635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24635
aacccatttt gaactcaaat                                                   20


<210> 24636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24636
ccaaatgcgt tgttgatgtt                                                   20


<210> 24637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24637
tacctttgtt agcaatccct                                                   20


<210> 24638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24638
gtacctttgt tagcaatccc                                                   20


<210> 24639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24639
ccactgcact gtacctttgt                                                   20


<210> 24640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24640
cactactctc ctcatcttca                                                   20


<210> 24641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24641
ccactactct cctcatcttc                                                   20


<210> 24642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24642
cattgtcaac ttccaatggc                                                   20


<210> 24643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24643
tggtcattgt caacttccaa                                                   20


<210> 24644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24644
cttcgatgat tgctctcaat                                                   20


<210> 24645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24645
gcttcttgtg cagttgtaag                                                   20


<210> 24646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24646
agcttcttgt gcagttgtaa                                                   20


<210> 24647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24647
tcagcttctt gtgcagttgt                                                   20


<210> 24648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24648
ttcttcctca gcttcttgtg                                                   20


<210> 24649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24649
gtcaacgatg agttcttcct                                                   20


<210> 24650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24650
accgtagaat ggtcaacgat                                                   20


<210> 24651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24651
actgccgaat gaccgtagaa                                                   20


<210> 24652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24652
cttcaactgc cgaatgaccg                                                   20


<210> 24653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24653
ttatgaggca cccatttatg                                                   20


<210> 24654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24654
gcttatgagg cacccattta                                                   20


<210> 24655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24655
acatttttcc ttagcttatg                                                   20


<210> 24656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24656
aacatttttc cttagcttat                                                   20


<210> 24657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24657
attttttaaa catttttcct                                                   20


<210> 24658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24658
atttttgttg catagaataa                                                   20


<210> 24659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24659
tcatttttgt tgcatagaat                                                   20


<210> 24660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24660
aatagttcat ttttgttgca                                                   20


<210> 24661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24661
atcacaatct gattaagaaa                                                   20


<210> 24662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24662
tcgcacatca caatctgatt                                                   20


<210> 24663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24663
gctggtcatt gccagttgtc                                                   20


<210> 24664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24664
gccaccaagc tggtcattgc                                                   20


<210> 24665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24665
tctcagtcca gccaccaagc                                                   20


<210> 24666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24666
ttcttctcag tccagccacc                                                   20


<210> 24667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24667
tttggagctt cttctcagtc                                                   20


<210> 24668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24668
agtgctttgg agcttcttct                                                   20


<210> 24669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24669
gggttttggg aagtgctttg                                                   20


<210> 24670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24670
ttgggttttg ggaagtgctt                                                   20


<210> 24671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24671
ggtgcaagtt gggttttggg                                                   20


<210> 24672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24672
tttggtgcaa gttgggtttt                                                   20


<210> 24673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24673
ttttggtgca agttgggttt                                                   20


<210> 24674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24674
gacttttttt ggtgcaagtt                                                   20


<210> 24675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24675
cgactttttt tggtgcaagt                                                   20


<210> 24676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24676
accacgactt tttttggtgc                                                   20


<210> 24677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24677
gcagtgacca cgactttttt                                                   20


<210> 24678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24678
accggcagca gaccaccaag                                                   20


<210> 24679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24679
cagaccggca gcagaccacc                                                   20


<210> 24680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24680
gtagtagatc agaccggcag                                                   20


<210> 24681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24681
gctgtagtag atcagaccgg                                                   20


<210> 24682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 24682
aaagctgtag tagatcagac                                                   20


<210> 24683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24683
ttcagaaagc tgtagtagat                                                   20


<210> 24684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24684
tgggattcag aaagctgtag                                                   20


<210> 24685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24685
tgctgggatt cagaaagctg                                                   20


<210> 24686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24686
tggctttgct gggattcaga                                                   20


<210> 24687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24687
gtaatggctt tgctgggatt                                                   20


<210> 24688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24688
tcagatgtaa tggctttgct                                                   20


<210> 24689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24689
ctcagatgta atggctttgc                                                   20


<210> 24690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24690
aacatatttc tcagatgtaa                                                   20


<210> 24691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24691
gatttgctga acatatttct                                                   20


<210> 24692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24692
aatgccagct gcaggccttg                                                   20


<210> 24693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24693
tgttgaccaa tgccagctgc                                                   20


<210> 24694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24694
ctgttgacca atgccagctg                                                   20


<210> 24695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24695
ccctttctgt tgaccaatgc                                                   20


<210> 24696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24696
ggttgttgtg gagaagaatt                                                   20


<210> 24697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24697
cggttgttgt ggagaagaat                                                   20


<210> 24698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24698
tgcagtcggt tgttgtggag                                                   20


<210> 24699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24699
acatgcagtc ggttgttgtg                                                   20


<210> 24700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24700
tgacatgcag tcggttgttg                                                   20


<210> 24701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 24701
ttggttgtgt gacatgcagt                                                   20


<210> 24702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24702
actgttggtt gtgtgacatg                                                   20


<210> 24703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24703
tcaacttttg aagtaactgt                                                   20


<210> 24704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24704
cccaattcat tcaacttttg                                                   20


<210> 24705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24705
gtggatgagg caaaacttca                                                   20


<210> 24706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24706
tcaggtgaat atggtggatg                                                   20


<210> 24707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24707
gtcaggtgaa tatggtggat                                                   20


<210> 24708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24708
gagaggtcag gtgaatatgg                                                   20


<210> 24709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24709
ggtgagaggt caggtgaata                                                   20


<210> 24710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24710
tagttggttg gtgagaggtc                                                   20


<210> 24711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24711
gtagttggtt ggtgagaggt                                                   20


<210> 24712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24712
agtggtagtt ggttggtgag                                                   20


<210> 24713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24713
aagtggtagt tggttggtga                                                   20


<210> 24714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24714
agaagtggta gttggttggt                                                   20


<210> 24715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24715
ttgaagaagt ggtagttggt                                                   20


<210> 24716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24716
atgcttgaag aagtggtagt                                                   20


<210> 24717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24717
tcagatgctt gaagaagtgg                                                   20


<210> 24718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24718
tgttcagatg cttgaagaag                                                   20


<210> 24719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24719
agttgttcag atgcttgaag                                                   20


<210> 24720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24720
aaaagttgtt cagatgcttg                                                   20


<210> 24721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24721
ttcacctgca aaaagttgtt                                                   20


<210> 24722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24722
ggaagtgttt cacctgcaaa                                                   20


<210> 24723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24723
ctgcatcccg ctggttatgg                                                   20


<210> 24724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24724
tttctgcatc ccgctggtta                                                   20


<210> 24725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24725
aggcattttc tgcatcccgc                                                   20


<210> 24726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24726
ggattcaatg aactcttgga                                                   20


<210> 24727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24727
gggattcaat gaactcttgg                                                   20


<210> 24728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24728
tttgggattc aatgaactct                                                   20


<210> 24729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24729
agcataaaaa tccatgcttt                                                   20


<210> 24730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24730
tagcataaaa atccatgctt                                                   20


<210> 24731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24731
aatgagtttg tttattcctg                                                   20


<210> 24732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24732
catttttgcc aatgagaaat                                                   20


<210> 24733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24733
atcaacacat ttttgccaat                                                   20


<210> 24734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24734
acatctttat taatcaaagt                                                   20


<210> 24735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24735
cacatcttta ttaatcaaag                                                   20


<210> 24736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24736
aaacacatct ttattaatca                                                   20


<210> 24737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24737
aatattaaat cattataact                                                   20


<210> 24738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24738
aaatattaaa tcattataac                                                   20


<210> 24739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24739
tacaaaagta attggggttt                                                   20


<210> 24740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24740
aaaaggtaca aaagtaattg                                                   20


<210> 24741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24741
gaaaaggtac aaaagtaatt                                                   20


<210> 24742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24742
tgaaaaggta caaaagtaat                                                   20


<210> 24743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24743
caaataatga aaaggtacaa                                                   20


<210> 24744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24744
agagatgcca aataatgaaa                                                   20


<210> 24745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24745
aagagatgcc aaataatgaa                                                   20


<210> 24746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24746
aaaaaataaa aagcaaataa                                                   20


<210> 24747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24747
tcaaaaaata aaaagcaaat                                                   20


<210> 24748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24748
attgtacatc aaaaaataaa                                                   20


<210> 24749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24749
tgacaaactc taaatactgg                                                   20


<210> 24750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24750
atatgacaaa ctctaaatac                                                   20


<210> 24751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24751
ggataaagat acaaactctt                                                   20


<210> 24752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24752
taaagacaac cactaggata                                                   20


<210> 24753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24753
tacttataaa gacaaccact                                                   20


<210> 24754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24754
ttacttataa agacaaccac                                                   20


<210> 24755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24755
ataataagtt tttacttata                                                   20


<210> 24756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24756
tataattata aatttataat                                                   20


<210> 24757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 24757
actaaggaca atgtattaca                                                   20


<210> 24758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24758
attaaagaaa tagtacacta                                                   20


<210> 24759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24759
gattaaagaa atagtacact                                                   20


<210> 24760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24760
agagattttg attaaagaaa                                                   20


<210> 24761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24761
gaaatgagag attttgatta                                                   20


<210> 24762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24762
gaatcaccaa atggaaatga                                                   20


<210> 24763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24763
aggaatcacc aaatggaaat                                                   20


<210> 24764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24764
agaggaaagg aatcaccaaa                                                   20


<210> 24765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24765
atggataaaa cagagaggaa                                                   20


<210> 24766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24766
aatggataaa acagagagga                                                   20


<210> 24767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24767
agataatgga taaaacagag                                                   20


<210> 24768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24768
cagataatgg ataaaacaga                                                   20


<210> 24769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24769
gtcagataat ggataaaaca                                                   20


<210> 24770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24770
cagtcagata atggataaaa                                                   20


<210> 24771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24771
tattaaatac agtcagataa                                                   20


<210> 24772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24772
aagatattat taaatacagt                                                   20


<210> 24773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24773
caaaaagata ttattaaata                                                   20


<210> 24774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24774
agtacaaagg taagcacaaa                                                   20


<210> 24775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24775
acacttgaca gtacaaaggt                                                   20


<210> 24776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24776
aattacactt gacagtacaa                                                   20


<210> 24777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24777
taattacact tgacagtaca                                                   20


<210> 24778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24778
gacaaaataa ttacacttga                                                   20


<210> 24779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24779
aaagttgaca aataaagaaa                                                   20


<210> 24780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24780
ttatttaaag ttgacaaata                                                   20


<210> 24781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24781
aagttaaaga gtattattta                                                   20


<210> 24782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24782
tataataaca agaagttaaa                                                   20


<210> 24783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24783
tctataataa caagaagtta                                                   20


<210> 24784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24784
gctgcttcta taataacaag                                                   20


<210> 24785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24785
actgctgctt ctataataac                                                   20


<210> 24786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24786
gaggaaagaa catgtgagca                                                   20


<210> 24787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24787
aagaggaaag aacatgtgag                                                   20


<210> 24788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24788
agaaagagga aagaacatgt                                                   20


<210> 24789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24789
aaatggaagc agaaagagga                                                   20


<210> 24790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24790
caagaaatgg aagcagaaag                                                   20


<210> 24791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24791
gcaagaaatg gaagcagaaa                                                   20


<210> 24792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24792
tagcaagaaa tggaagcaga                                                   20


<210> 24793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24793
caaatagcaa gaaatggaag                                                   20


<210> 24794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24794
atacaaatag caagaaatgg                                                   20


<210> 24795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24795
atgatacaaa tagcaagaaa                                                   20


<210> 24796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24796
gttgacatga tacaaatagc                                                   20


<210> 24797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24797
aagtgttgac atgatacaaa                                                   20


<210> 24798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24798
acaagcccca gaggccctgc                                                   20


<210> 24799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24799
cgctgcccaa caagccccag                                                   20


<210> 24800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24800
ccgctgccca acaagcccca                                                   20


<210> 24801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24801
ccccgctgcc caacaagccc                                                   20


<210> 24802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24802
taccgccccc gctgcccaac                                                   20


<210> 24803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24803
ggggataaaa atgagaataa                                                   20


<210> 24804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24804
gggggataaa aatgagaata                                                   20


<210> 24805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24805
ctccagaggg ggataaaaat                                                   20


<210> 24806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24806
aaccacggtg cctccagagg                                                   20


<210> 24807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24807
aaaccacggt gcctccagag                                                   20


<210> 24808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24808
taaaccacgg tgcctccaga                                                   20


<210> 24809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24809
ttaaaccacg gtgcctccag                                                   20


<210> 24810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24810
gttaaaccac ggtgcctcca                                                   20


<210> 24811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24811
ttgttaaacc acggtgcctc                                                   20


<210> 24812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 24812
gatcagggtt tgttaaacca                                                   20


<210> 24813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24813
gtaaatcact tagcagatca                                                   20


<210> 24814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24814
ggtaaatcac ttagcagatc                                                   20


<210> 24815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24815
tggtaaatca cttagcagat                                                   20


<210> 24816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24816
agaagtggta aatcacttag                                                   20


<210> 24817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24817
tggagaagtg gtaaatcact                                                   20


<210> 24818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24818
accaaaagtg ggtggagaag                                                   20


<210> 24819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24819
aagaccaaaa gtgggtggag                                                   20


<210> 24820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24820
tggaagacca aaagtgggtg                                                   20


<210> 24821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24821
cttggaagac caaaagtggg                                                   20


<210> 24822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24822
acacttggaa gaccaaaagt                                                   20


<210> 24823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24823
aacacttgga agaccaaaag                                                   20


<210> 24824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24824
caaaacactt ggaagaccaa                                                   20


<210> 24825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24825
aatgatgtca aaacacttgg                                                   20


<210> 24826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24826
acaaatgatg tcaaaacact                                                   20


<210> 24827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24827
aaagagaatg gaaaacacag                                                   20


<210> 24828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24828
gaaagagaat ggaaaacaca                                                   20


<210> 24829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24829
gagaaagaga atggaaaaca                                                   20


<210> 24830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24830
aagaacaaag agaaagagaa                                                   20


<210> 24831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24831
tatacaagaa caaagagaaa                                                   20


<210> 24832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24832
aatatacaag aacaaagaga                                                   20


<210> 24833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24833
tataaatata caagaacaaa                                                   20


<210> 24834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24834
agtataaata tacaagaaca                                                   20


<210> 24835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24835
aaagaacagt ataaatatac                                                   20


<210> 24836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24836
tgacagcacg ggggaaagaa                                                   20


<210> 24837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24837
tagaatgaca gcacggggga                                                   20


<210> 24838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24838
ccaatagaat gacagcacgg                                                   20


<210> 24839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24839
gccaatagaa tgacagcacg                                                   20


<210> 24840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24840
tgccaataga atgacagcac                                                   20


<210> 24841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 24841
atgccaatag aatgacagca                                                   20


<210> 24842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24842
tcaaaatgcc aatagaatga                                                   20


<210> 24843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24843
ccaccctctc aaaatgccaa                                                   20


<210> 24844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24844
ttgtggttaa atatggaaga                                                   20


<210> 24845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24845
gagattgtgg ttaaatatgg                                                   20


<210> 24846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24846
ttggagattg tggttaaata                                                   20


<210> 24847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24847
tgggagttat ttggagattg                                                   20


<210> 24848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24848
agttatttgg gagttatttg                                                   20


<210> 24849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24849
tgagttattt gggagttatt                                                   20


<210> 24850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24850
ttgcaaaatg agttatttgg                                                   20


<210> 24851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24851
ttttgcaaaa tgagttattt                                                   20


<210> 24852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24852
tttttgcaaa atgagttatt                                                   20


<210> 24853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24853
aaaacatttt tttgcaaaat                                                   20


<210> 24854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24854
aaatgtctat gcttcttttg                                                   20


<210> 24855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24855
taaaatgtct atgcttcttt                                                   20


<210> 24856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24856
ttaatattgt tgagatcata                                                   20


<210> 24857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24857
aaattatatt taatattgtt                                                   20


<210> 24858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24858
cagaagatgg ttactaagta                                                   20


<210> 24859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24859
atcagaagat ggttactaag                                                   20


<210> 24860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24860
taaatcagaa gatggttact                                                   20


<210> 24861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24861
tgaaaatata aatcagaaga                                                   20


<210> 24862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24862
acactgaaaa tataaatcag                                                   20


<210> 24863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24863
agaacactga aaatataaat                                                   20


<210> 24864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24864
aatgaccatt gcaaaaaatg                                                   20


<210> 24865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24865
gtattttgtt aaggcaacaa                                                   20


<210> 24866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24866
ggtattttgt taaggcaaca                                                   20


<210> 24867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24867
cagtctatgg tattttgtta                                                   20


<210> 24868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24868
ccagtctatg gtattttgtt                                                   20


<210> 24869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24869
tgcataagcc acccagtcta                                                   20


<210> 24870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24870
tttctgttgc ataagccacc                                                   20


<210> 24871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24871
aaaataaatt tctgttgcat                                                   20


<210> 24872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24872
gcttcaacct ccagatttgt                                                   20


<210> 24873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24873
caatctcagg cttcaacctc                                                   20


<210> 24874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24874
tatgctgaca tcccaatctc                                                   20


<210> 24875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24875
ctatgctgac atcccaatct                                                   20


<210> 24876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24876
gctagaaaga gagtctttcc                                                   20


<210> 24877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24877
acatctataa gctagaaaga                                                   20


<210> 24878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24878
agacatctat aagctagaaa                                                   20


<210> 24879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24879
gtagacatct ataagctaga                                                   20


<210> 24880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24880
caaggtagac atctataagc                                                   20


<210> 24881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24881
aggacaaggt agacatctat                                                   20


<210> 24882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24882
gtgagaacac aaggacaagg                                                   20


<210> 24883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24883
tgtgtgagaa cacaaggaca                                                   20


<210> 24884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24884
ttgtgtgaga acacaaggac                                                   20


<210> 24885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24885
cccctttgtg tgagaacaca                                                   20


<210> 24886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24886
tcccctttgt gtgagaacac                                                   20


<210> 24887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24887
cagctttctc ccctttgtgt                                                   20


<210> 24888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24888
gtccttataa gagaaagaga                                                   20


<210> 24889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24889
tggtgtcctt ataagagaaa                                                   20


<210> 24890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24890
actggtgtcc ttataagaga                                                   20


<210> 24891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24891
tagaactggt gtccttataa                                                   20


<210> 24892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24892
ggtagaactg gtgtccttat                                                   20


<210> 24893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24893
gagcccttaa gtggtagaac                                                   20


<210> 24894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24894
agagtagagc ccttaagtgg                                                   20


<210> 24895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24895
acaagagtag agcccttaag                                                   20


<210> 24896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24896
gtcacaagag tagagccctt                                                   20


<210> 24897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24897
taaatgaagt cacaagagta                                                   20


<210> 24898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24898
gttaaatgaa gtcacaagag                                                   20


<210> 24899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24899
tgggttaaat gaagtcacaa                                                   20


<210> 24900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24900
attgggttaa atgaagtcac                                                   20


<210> 24901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24901
ggaggtgatt gggttaaatg                                                   20


<210> 24902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24902
gggcctctaa ggaggtgatt                                                   20


<210> 24903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24903
tgggcctcta aggaggtgat                                                   20


<210> 24904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24904
tggagattgg gcctctaagg                                                   20


<210> 24905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24905
ttggagattg ggcctctaag                                                   20


<210> 24906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24906
tgttggagat tgggcctcta                                                   20


<210> 24907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24907
atgttggaga ttgggcctct                                                   20


<210> 24908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24908
atgttgctat gttggagatt                                                   20


<210> 24909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24909
catgttgcta tgttggagat                                                   20


<210> 24910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24910
ccccccatgt tgctatgttg                                                   20


<210> 24911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24911
aaccccccat gttgctatgt                                                   20


<210> 24912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24912
ttgtcacaca agctgctatg                                                   20


<210> 24913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24913
agttgtcaca caagctgcta                                                   20


<210> 24914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24914
ggcatgggta gttgtcacac                                                   20


<210> 24915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24915
gttccatttt atggcatggg                                                   20


<210> 24916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24916
cacgttccat tttatggcat                                                   20


<210> 24917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24917
tcacgttcca ttttatggca                                                   20


<210> 24918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24918
gctggtcacg ttccatttta                                                   20


<210> 24919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24919
ggaaggagct ggtgaagtgc                                                   20


<210> 24920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24920
taattgggaa ggagctggtg                                                   20


<210> 24921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24921
ggatgtaatt gggaaggagc                                                   20


<210> 24922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24922
gggaggatgt aattgggaag                                                   20


<210> 24923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24923
gagggaggat gtaattggga                                                   20


<210> 24924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24924
agagggagga tgtaattggg                                                   20


<210> 24925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24925
agaagaggga ggatgtaatt                                                   20


<210> 24926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24926
cagaagaggg aggatgtaat                                                   20


<210> 24927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24927
gcctccaggg cagaagaggg                                                   20


<210> 24928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24928
ggcctccagg gcagaagagg                                                   20


<210> 24929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24929
gtggcctcca gggcagaaga                                                   20


<210> 24930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24930
agtggcctcc agggcagaag                                                   20


<210> 24931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24931
tagtggcctc cagggcagaa                                                   20


<210> 24932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24932
aatagtggcc tccagggcag                                                   20


<210> 24933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24933
gagaatagtg gcctccaggg                                                   20


<210> 24934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24934
taggagaata gtggcctcca                                                   20


<210> 24935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24935
ttaggagaat agtggcctcc                                                   20


<210> 24936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24936
attaggagaa tagtggcctc                                                   20


<210> 24937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24937
accaaaaatt aggagaatag                                                   20


<210> 24938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24938
agtaccaaaa attaggagaa                                                   20


<210> 24939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24939
gaaaaagtac caaaaattag                                                   20


<210> 24940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24940
aagaaaaagt accaaaaatt                                                   20


<210> 24941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24941
caagaaaaag taccaaaaat                                                   20


<210> 24942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24942
caataaagta aggcaagaaa                                                   20


<210> 24943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24943
aagcatcaat aaagtaaggc                                                   20


<210> 24944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24944
taaaaagcat caataaagta                                                   20


<210> 24945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24945
gtaaaaagca tcaataaagt                                                   20


<210> 24946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24946
tgaagtaaaa agcatcaata                                                   20


<210> 24947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24947
atgcatactt atgaagtaaa                                                   20


<210> 24948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24948
tttaggaatg catacttatg                                                   20


<210> 24949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24949
aaaactaaac tattttgttt                                                   20


<210> 24950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24950
caaaactaaa ctattttgtt                                                   20


<210> 24951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24951
tttatataaa gtttgaaatc                                                   20


<210> 24952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24952
aaacaaggtt catttatata                                                   20


<210> 24953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24953
tgcaaaggat tacataaaca                                                   20


<210> 24954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24954
atgcaaagga ttacataaac                                                   20


<210> 24955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24955
acaaaaaaag ccaaatgcaa                                                   20


<210> 24956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24956
aacaaaaaaa gccaaatgca                                                   20


<210> 24957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24957
aaagtaatat tgaacaaaaa                                                   20


<210> 24958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24958
aataaggatg agtcttaaga                                                   20


<210> 24959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24959
caacaataag gatgagtctt                                                   20


<210> 24960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24960
tgctgcacaa caataaggat                                                   20


<210> 24961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24961
tttagtgctg cacaacaata                                                   20


<210> 24962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24962
ctttagtgct gcacaacaat                                                   20


<210> 24963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24963
caataaaaat taataaactt                                                   20


<210> 24964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24964
ttctaaaatg agaaaactta                                                   20


<210> 24965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24965
tttctgttat attctaaaat                                                   20


<210> 24966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24966
ctcaaatgtc cataaacttt                                                   20


<210> 24967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 24967
tgcccataaa aaccccaaac                                                   20


<210> 24968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24968
accagattac agctacaaga                                                   20


<210> 24969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24969
ggacaccaga ttacagctac                                                   20


<210> 24970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24970
tacttgtgga caccagatta                                                   20


<210> 24971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24971
aaatatgtac ttgtggacac                                                   20


<210> 24972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24972
ttaacagaaa tatgtacttg                                                   20


<210> 24973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24973
ccttaggtac ctatgtttaa                                                   20


<210> 24974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24974
tattcttcta ttacaccctt                                                   20


<210> 24975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24975
gtattcttct attacaccct                                                   20


<210> 24976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24976
gtattatcta gtaaaggtgt                                                   20


<210> 24977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24977
caaggggtat tatctagtaa                                                   20


<210> 24978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24978
gcaaggggta ttatctagta                                                   20


<210> 24979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 24979
ggaaagcaag gggtattatc                                                   20


<210> 24980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24980
caacctcttt ggaaagcaag                                                   20


<210> 24981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24981
acaacctctt tggaaagcaa                                                   20


<210> 24982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24982
gacaacctct ttggaaagca                                                   20


<210> 24983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24983
ggacaacctc tttggaaagc                                                   20


<210> 24984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24984
atttggacaa cctctttgga                                                   20


<210> 24985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24985
gtaaatttgg acaacctctt                                                   20


<210> 24986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24986
tgctggtggg agtgtaaatt                                                   20


<210> 24987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24987
aactcacaca ctgctggtgg                                                   20


<210> 24988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24988
gaaactcaca cactgctggt                                                   20


<210> 24989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24989
agaaactcac acactgctgg                                                   20


<210> 24990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24990
aacagaaact cacacactgc                                                   20


<210> 24991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 24991
ttgggaatga catggagcaa                                                   20


<210> 24992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 24992
caagtattgg gaatgacatg                                                   20


<210> 24993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24993
accaagtatt gggaatgaca                                                   20


<210> 24994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24994
gtgtcacaat accaagtatt                                                   20


<210> 24995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 24995
agtgtcacaa taccaagtat                                                   20


<210> 24996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24996
ttttaaagtg tcacaatacc                                                   20


<210> 24997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 24997
catagaaggg aaatttttta                                                   20


<210> 24998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 24998
attacatgtt catcatagaa                                                   20


<210> 24999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 24999
tattacatgt tcatcataga                                                   20


<210> 25000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25000
ttattacatg ttcatcatag                                                   20


<210> 25001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25001
attttattac atgttcatca                                                   20


<210> 25002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25002
ttgcaaatta aaatcacact                                                   20


<210> 25003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25003
taaccttttt ttaaatcaaa                                                   20


<210> 25004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25004
cttaaccttt ttttaaatca                                                   20


<210> 25005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25005
aaatggccat aaacatatga                                                   20


<210> 25006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25006
tacaaaagtg gaaatccaaa                                                   20


<210> 25007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25007
gaataggcac tttacaaaag                                                   20


<210> 25008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25008
tttgaatagg cactttacaa                                                   20


<210> 25009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25009
aaatagcaca aaatttgaat                                                   20


<210> 25010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25010
aaaatagcac aaaatttgaa                                                   20


<210> 25011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25011
cagaacaacc acttgtaaaa                                                   20


<210> 25012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25012
caaatcaatt agaaaaatgt                                                   20


<210> 25013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25013
aatgaactct acaaatcaat                                                   20


<210> 25014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25014
aaagcaagtg cttatattca                                                   20


<210> 25015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25015
aaaaagcaag tgcttatatt                                                   20


<210> 25016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25016
ctttaagagc atgaaaaagc                                                   20


<210> 25017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25017
acaactttaa gagcatgaaa                                                   20


<210> 25018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25018
tcatcagaag acaactttaa                                                   20


<210> 25019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25019
gttcatcaga agacaacttt                                                   20


<210> 25020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25020
taattaagaa tgttcatcag                                                   20


<210> 25021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25021
ctataattaa gaatgttcat                                                   20


<210> 25022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25022
cattttagta tactataatt                                                   20


<210> 25023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25023
aggaaaaaac tgatacattt                                                   20


<210> 25024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25024
acaagaagca ctaactatac                                                   20


<210> 25025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25025
cacaagaagc actaactata                                                   20


<210> 25026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25026
tttattacat atgacacaag                                                   20


<210> 25027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25027
aactttatta catatgacac                                                   20


<210> 25028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25028
tatctttatg acctcagact                                                   20


<210> 25029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25029
gaggaatatc tttatgacct                                                   20


<210> 25030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25030
tttgaaagga aaaaacaaag                                                   20


<210> 25031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25031
ttttgaaagg aaaaaacaaa                                                   20


<210> 25032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25032
ctttttgaaa ggaaaaaaca                                                   20


<210> 25033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25033
tggtggataa gctttttgaa                                                   20


<210> 25034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25034
gtggtggata agctttttga                                                   20


<210> 25035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25035
ccgacttgat cgtggtggat                                                   20


<210> 25036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25036
tgaagccgac ttgatcgtgg                                                   20


<210> 25037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25037
gtatgaagcc gacttgatcg                                                   20


<210> 25038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25038
cagctttgat cccaggtatg                                                   20


<210> 25039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25039
gttgaaccag ctttgatccc                                                   20


<210> 25040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25040
tgttgaacca gctttgatcc                                                   20


<210> 25041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25041
ttgacttgcg tatgttgaac                                                   20


<210> 25042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25042
cattggttct gtttgtgtga                                                   20


<210> 25043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25043
aatcacgtgg tttttgtcat                                                   20


<210> 25044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25044
catctattga gataatcacg                                                   20


<210> 25045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25045
agaccttttc tgcatctatt                                                   20


<210> 25046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25046
atgggtgttg aattttgtcg                                                   20


<210> 25047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25047
tgagagcttt tagcatgaat                                                   20


<210> 25048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25048
ttgagagctt ttagcatgaa                                                   20


<210> 25049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25049
cctagtttat tgagagcttt                                                   20


<210> 25050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25050
atcaatacct agtttattga                                                   20


<210> 25051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25051
ccatcaatac ctagtttatt                                                   20


<210> 25052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25052
agatacattc catcaatacc                                                   20


<210> 25053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25053
taaatagttc ttattatttt                                                   20


<210> 25054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25054
ggctgggggc ttgtcataaa                                                   20


<210> 25055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25055
ttcagtatga tattggctgg                                                   20


<210> 25056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25056
attcagtatg atattggctg                                                   20


<210> 25057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25057
cattcagtat gatattggct                                                   20


<210> 25058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25058
ccattcagta tgatattggc                                                   20


<210> 25059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25059
ttgcccattc agtatgatat                                                   20


<210> 25060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25060
gcttccagtt tttgcccatt                                                   20


<210> 25061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25061
gttttcaaag gaaatgcttc                                                   20


<210> 25062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25062
tgtcttgtgc tggttttcaa                                                   20


<210> 25063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25063
ttgtcttgtg ctggttttca                                                   20


<210> 25064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25064
agggcattct tgtcttgtgc                                                   20


<210> 25065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25065
tgaataagag tggtgagata                                                   20


<210> 25066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25066
ttgaataaga gtggtgagat                                                   20


<210> 25067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25067
gttgaataag agtggtgaga                                                   20


<210> 25068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25068
ctatgttgaa taagagtggt                                                   20


<210> 25069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25069
aatactatgt tgaataagag                                                   20


<210> 25070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25070
tccaatacta tgttgaataa                                                   20


<210> 25071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25071
cttccaatac tatgttgaat                                                   20


<210> 25072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25072
tcttgcctga tcgccctggc                                                   20


<210> 25073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25073
tttctcttgc ctgatcgccc                                                   20


<210> 25074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25074
agtcatgtca tctgcaaaca                                                   20


<210> 25075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25075
acagtcatgt catctgcaaa                                                   20


<210> 25076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25076
gatggggttt tctaaatata                                                   20


<210> 25077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25077
gattttgggc tgagatgatg                                                   20


<210> 25078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25078
agattttggg ctgagatgat                                                   20


<210> 25079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25079
gagattttgg gctgagatga                                                   20


<210> 25080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25080
gcttaaggag attttgggct                                                   20


<210> 25081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25081
tatcagctta aggagatttt                                                   20


<210> 25082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25082
ttatcagctt aaggagattt                                                   20


<210> 25083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25083
aagttgctta tcagcttaag                                                   20


<210> 25084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25084
tgaagttgct tatcagctta                                                   20


<210> 25085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25085
ctgaagttgc ttatcagctt                                                   20


<210> 25086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25086
actttgctga agttgcttat                                                   20


<210> 25087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25087
tgtatcctga gactttgctg                                                   20


<210> 25088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25088
gcacattgat tttgtatcct                                                   20


<210> 25089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25089
tttgtctgtt attggtgtat                                                   20


<210> 25090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25090
gtttgtctgt tattggtgta                                                   20


<210> 25091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25091
gctctcggtt tgtctgttat                                                   20


<210> 25092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 25092
ttcactcatg atttggctct                                                   20


<210> 25093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25093
atgggagttc actcatgatt                                                   20


<210> 25094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25094
tttgttgcaa ttgtgaatgg                                                   20


<210> 25095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25095
tctttgttgc aattgtgaat                                                   20


<210> 25096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25096
ctctttgttg caattgtgaa                                                   20


<210> 25097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25097
tcccttgtaa gttgtatttc                                                   20


<210> 25098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25098
aggtccttca catcccttgt                                                   20


<210> 25099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25099
atttttagtt ctccttgaag                                                   20


<210> 25100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25100
gatttttagt tctccttgaa                                                   20


<210> 25101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25101
gtgattttta gttctccttg                                                   20


<210> 25102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25102
tttccttgag cagtgatttt                                                   20


<210> 25103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25103
tcctctctta tttccttgag                                                   20


<210> 25104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25104
gtgtcctctc ttatttcctt                                                   20


<210> 25105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25105
atttttccta tccatgagca                                                   20


<210> 25106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25106
tattgatttt tcctatccat                                                   20


<210> 25107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25107
ataaattact ttgggcagta                                                   20


<210> 25108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25108
aatctataaa ttactttggg                                                   20


<210> 25109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25109
ttgaatctat aaattacttt                                                   20


<210> 25110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25110
attgaatcta taaattactt                                                   20


<210> 25111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25111
aagtcagtgg tagcttgatg                                                   20


<210> 25112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25112
aaagtcagtg gtagcttgat                                                   20


<210> 25113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25113
gaaagtcagt ggtagcttga                                                   20


<210> 25114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25114
tctgtgaaga aagtcagtgg                                                   20


<210> 25115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25115
aattctgtga agaaagtcag                                                   20


<210> 25116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25116
tctaattctg tgaagaaagt                                                   20


<210> 25117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25117
tttttctaat tctgtgaaga                                                   20


<210> 25118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25118
tagatttttc taattctgtg                                                   20


<210> 25119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25119
gttccacatg aaatttaaag                                                   20


<210> 25120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25120
tttgttccac atgaaattta                                                   20


<210> 25121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25121
tagaattgtc ttgactatgc                                                   20


<210> 25122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 25122
ttagaattgt cttgactatg                                                   20


<210> 25123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25123
ccaactttct tctttttgct                                                   20


<210> 25124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25124
tagtatagct tgaagtcagg                                                   20


<210> 25125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25125
ttgtagtata gcttgaagtc                                                   20


<210> 25126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25126
tttgtagtat agcttgaagt                                                   20


<210> 25127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25127
tagctttgta gtatagcttg                                                   20


<210> 25128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25128
gttactgtag ctttgtagta                                                   20


<210> 25129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25129
ttttggttac tgtagctttg                                                   20


<210> 25130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25130
cctcgctgtt ttggttactg                                                   20


<210> 25131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25131
gtaccagtac ctcgctgttt                                                   20


<210> 25132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25132
ctagatatct gttttggtac                                                   20


<210> 25133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25133
attggtctag atatctgttt                                                   20


<210> 25134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25134
tctgttctgt tccattggtc                                                   20


<210> 25135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25135
aggcctctgt tctgttccat                                                   20


<210> 25136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25136
gatatgcggt gttacttctg                                                   20


<210> 25137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25137
agatatgcgg tgttacttct                                                   20


<210> 25138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 25138
atcagatggt tgtagatatg                                                   20


<210> 25139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25139
tgtcaaagat cagatggttg                                                   20


<210> 25140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25140
caagtttgtc aaagatcaga                                                   20


<210> 25141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25141
ttgtcaagtt tgtcaaagat                                                   20


<210> 25142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25142
tgcttttgtc aagtttgtca                                                   20


<210> 25143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25143
ccccattgct tgcttttgtc                                                   20


<210> 25144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25144
cccacaccat ttattaaata                                                   20


<210> 25145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25145
ccccacacca tttattaaat                                                   20


<210> 25146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25146
tccccacacc atttattaaa                                                   20


<210> 25147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25147
attttctgcc taaggctagc                                                   20


<210> 25148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25148
ttcaattttc tgcctaaggc                                                   20


<210> 25149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25149
tagtttcaat tttctgccta                                                   20


<210> 25150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25150
ctagtttcaa ttttctgcct                                                   20


<210> 25151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25151
taaggtataa ggaagggatc                                                   20


<210> 25152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25152
tttgtgtaag gtataaggaa                                                   20


<210> 25153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25153
ttttgtgtaa ggtataagga                                                   20


<210> 25154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25154
tttttgtgta aggtataagg                                                   20


<210> 25155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25155
taatttttgt gtaaggtata                                                   20


<210> 25156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25156
ttaatttttg tgtaaggtat                                                   20


<210> 25157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25157
cttgagttaa tttttgtgta                                                   20


<210> 25158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25158
tcttgagtta atttttgtgt                                                   20


<210> 25159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25159
ttaagtcttt aatctatctt                                                   20


<210> 25160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25160
tggttttagg tcttatgttt                                                   20


<210> 25161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25161
tctagggttt ttatggtttt                                                   20


<210> 25162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25162
ttctagggtt tttatggttt                                                   20


<210> 25163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25163
gttttcttct agggttttta                                                   20


<210> 25164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25164
attgcctagg ttttcttcta                                                   20


<210> 25165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25165
tattgcctag gttttcttct                                                   20


<210> 25166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25166
gtattgccta ggttttcttc                                                   20


<210> 25167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25167
tgtcctgaag ggtattgcct                                                   20


<210> 25168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25168
atgtcctgaa gggtattgcc                                                   20


<210> 25169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25169
gcccatgcct atgtcctgaa                                                   20


<210> 25170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25170
tgcccatgcc tatgtcctga                                                   20


<210> 25171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25171
ttgcccatgc ctatgtcctg                                                   20


<210> 25172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25172
cttttgatgt gttagtcata                                                   20


<210> 25173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25173
caccattgct tttgatgtgt                                                   20


<210> 25174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25174
tggattccat ttgtcaattt                                                   20


<210> 25175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25175
cagaagctct ttagtttaat                                                   20


<210> 25176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25176
tttgctgtgc agaagctctt                                                   20


<210> 25177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25177
tagtttcttt tgctgtgcag                                                   20


<210> 25178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25178
tgatagtttc ttttgctgtg                                                   20


<210> 25179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25179
ttacctattc actctgatga                                                   20


<210> 25180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25180
aaaattttct cccattctgt                                                   20


<210> 25181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25181
aaaaattttc tcccattctg                                                   20


<210> 25182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25182
ttagcccttt gtcagattga                                                   20


<210> 25183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25183
tctggatatt agccctttgt                                                   20


<210> 25184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25184
tttttgtaga ttctggatat                                                   20


<210> 25185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25185
tttaagtttt ttgtagattc                                                   20


<210> 25186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25186
aaatttgttt aagttttttg                                                   20


<210> 25187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25187
tttttcttgt aaatttgttt                                                   20


<210> 25188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25188
cctttgccca ctttttgatg                                                   20


<210> 25189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25189
atcctttgcc cactttttga                                                   20


<210> 25190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25190
cataaatgtc ttcttttgag                                                   20


<210> 25191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25191
ctgcataaat gtcttctttt                                                   20


<210> 25192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25192
gctttttatc atatgtttat                                                   20


<210> 25193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25193
ctctaatgac cagtgatgat                                                   20


<210> 25194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25194
actggcattt ctctaatgac                                                   20


<210> 25195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25195
catctcattg tggttttgac                                                   20


<210> 25196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25196
tatgagactc catctcattg                                                   20


<210> 25197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25197
atctccattc taactggtat                                                   20


<210> 25198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25198
ttaatgatct ccattctaac                                                   20


<210> 25199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25199
ctatctctcc acatcctctc                                                   20


<210> 25200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25200
cactcccacc aacagtgtaa                                                   20


<210> 25201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25201
ctaatttaca ctcccaccaa                                                   20


<210> 25202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25202
caccacactg tcttccacaa                                                   20


<210> 25203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25203
tttctggttc tagatccttg                                                   20


<210> 25204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25204
gtttctggtt ctagatcctt                                                   20


<210> 25205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25205
tcaaatggtg tttctggttc                                                   20


<210> 25206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25206
gctgggtcaa atggtgtttc                                                   20


<210> 25207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25207
aatggaattg ctgggtcaaa                                                   20


<210> 25208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25208
tacccagtaa tggaattgct                                                   20


<210> 25209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25209
atacccagta atggaattgc                                                   20


<210> 25210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25210
tttgggtata tacccagtaa                                                   20


<210> 25211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25211
taatcctttg ggtatatacc                                                   20


<210> 25212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25212
agaataattt ataatccttt                                                   20


<210> 25213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25213
tagaataatt tataatcctt                                                   20


<210> 25214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25214
gcatgcttgt atctttatag                                                   20


<210> 25215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25215
tacgcatgct tgtatcttta                                                   20


<210> 25216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25216
caagtctttg ctattgtcaa                                                   20


<210> 25217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25217
tgggcgtttg ggttagttcc                                                   20


<210> 25218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25218
tcactgatgg gcgtttgggt                                                   20


<210> 25219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25219
tctatcactg atgggcgttt                                                   20


<210> 25220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25220
gtctatcact gatgggcgtt                                                   20


<210> 25221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25221
ttatccagtc tatcactgat                                                   20


<210> 25222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25222
tttatccagt ctatcactga                                                   20


<210> 25223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25223
tgtgccatat tttctttatc                                                   20


<210> 25224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25224
tatggctgca tagtattcca                                                   20


<210> 25225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25225
cacccttttt tatggctgca                                                   20


<210> 25226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25226
catgaactca ccctttttta                                                   20


<210> 25227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25227
gcttcatcca tgtccctgca                                                   20


<210> 25228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25228
ttgctgagaa tgatggtttc                                                   20


<210> 25229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25229
tgtcagtttg ctgagaatga                                                   20


<210> 25230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25230
tgttcttatg tcagtttgct                                                   20


<210> 25231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25231
ttggttttct gttcttatgt                                                   20


<210> 25232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25232
gagtgagaac atgcggtgtt                                                   20


<210> 25233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 25233
cacctatgag tgagaacatg                                                   20


<210> 25234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25234
ttcatctccc acctatgagt                                                   20


<210> 25235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25235
attgttcatc tcccacctat                                                   20


<210> 25236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25236
cccaacccct caacaggccc                                                   20


<210> 25237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25237
ctagccccca acccctcaac                                                   20


<210> 25238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25238
cctagccccc aacccctcaa                                                   20


<210> 25239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25239
tcctaatgct atccctcccc                                                   20


<210> 25240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25240
atcaacccat catctacatt                                                   20


<210> 25241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25241
catcaaccca tcatctacat                                                   20


<210> 25242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25242
taggtataca catgtcatgg                                                   20


<210> 25243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25243
acataggtat acacatgtca                                                   20


<210> 25244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25244
aaagtgcagg tttgttacat                                                   20


<210> 25245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25245
gaaagtgcag gtttgttaca                                                   20


<210> 25246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25246
ggtacatgtg cagaaagtgc                                                   20


<210> 25247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25247
gggtacatgt gcagaaagtg                                                   20


<210> 25248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25248
ttctggggta catgtgcaga                                                   20


<210> 25249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25249
taagttctgg ggtacatgtg                                                   20


<210> 25250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25250
aaattttact ttaagttctg                                                   20


<210> 25251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25251
taaattttac tttaagttct                                                   20


<210> 25252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25252
ttaaatttta ctttaagttc                                                   20


<210> 25253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25253
ccttttttaa attttacttt                                                   20


<210> 25254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25254
ttgtgaaatg caaatatata                                                   20


<210> 25255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25255
acacaagaat caattctagg                                                   20


<210> 25256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25256
cacacacaag aatcaattct                                                   20


<210> 25257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25257
ccacacacaa gaatcaattc                                                   20


<210> 25258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25258
tccaactttg caccacacac                                                   20


<210> 25259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25259
tgaagaatta ggaatctcac                                                   20


<210> 25260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25260
aaaaatgatg ctgaagaatt                                                   20


<210> 25261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25261
aaaaaatgat gctgaagaat                                                   20


<210> 25262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25262
gtcttcaaaa aatgatgctg                                                   20


<210> 25263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 25263
ccagaacagc agggaaaagg                                                   20


<210> 25264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25264
accccagaac agcagggaaa                                                   20


<210> 25265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25265
caccccagaa cagcagggaa                                                   20


<210> 25266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25266
ggtggcaccc cagaacagca                                                   20


<210> 25267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25267
aggtggcacc ccagaacagc                                                   20


<210> 25268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25268
aaggtggcac cccagaacag                                                   20


<210> 25269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25269
gaaaaggtgg caccccagaa                                                   20


<210> 25270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25270
tgtgtgaaaa ggtggcaccc                                                   20


<210> 25271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25271
acatctaatg tgtgaaaagg                                                   20


<210> 25272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25272
taaacatcta atgtgtgaaa                                                   20


<210> 25273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25273
gtaaacatct aatgtgtgaa                                                   20


<210> 25274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25274
cagcatagac agtccataaa                                                   20


<210> 25275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25275
gaataatgta acagcataga                                                   20


<210> 25276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25276
gtcagaataa tgtaacagca                                                   20


<210> 25277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25277
gattggtcag aataatgtaa                                                   20


<210> 25278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25278
gccattggtg taagattggt                                                   20


<210> 25279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25279
gtgtgccatt ggtgtaagat                                                   20


<210> 25280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25280
aagcagtgtg ccattggtgt                                                   20


<210> 25281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25281
taattgaagc agtgtgccat                                                   20


<210> 25282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25282
ctataaagct ctaattgaag                                                   20


<210> 25283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25283
ttactataaa gctctaattg                                                   20


<210> 25284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25284
ggatgtcgag atttactata                                                   20


<210> 25285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25285
aactcattct actggatgtc                                                   20


<210> 25286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25286
agtgggagaa ctcattctac                                                   20


<210> 25287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25287
gaggaagaaa tacaaagtgg                                                   20


<210> 25288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25288
ttgaggaaga aatacaaagt                                                   20


<210> 25289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25289
tttgaggaag aaatacaaag                                                   20


<210> 25290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25290
acttttgagg aagaaataca                                                   20


<210> 25291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25291
tagccaagaa acttttgagg                                                   20


<210> 25292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25292
ttatagccaa gaaacttttg                                                   20


<210> 25293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25293
attatagcca agaaactttt                                                   20


<210> 25294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25294
ttaaagagca aattatagcc                                                   20


<210> 25295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25295
aaattttaaa gagcaaatta                                                   20


<210> 25296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25296
agtttacatg aaattttaaa                                                   20


<210> 25297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25297
aaagtttaca tgaaatttta                                                   20


<210> 25298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25298
ctttaaattt tcttcctcaa                                                   20


<210> 25299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25299
atatttcaac aggcttcttt                                                   20


<210> 25300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25300
cctcaaatca atatttcaac                                                   20


<210> 25301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25301
tcctcaaatc aatatttcaa                                                   20


<210> 25302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25302
ttcaaagtct caatattgta                                                   20


<210> 25303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25303
gagacatgtt ctcagattca                                                   20


<210> 25304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25304
tcagtgggga gacatgttct                                                   20


<210> 25305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25305
aagaaaacca aatcagtggg                                                   20


<210> 25306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25306
taaagaaaac caaatcagtg                                                   20


<210> 25307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25307
ttaaagaaaa ccaaatcagt                                                   20


<210> 25308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25308
tttaaagaaa accaaatcag                                                   20


<210> 25309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25309
gtttttaaag aaaaccaaat                                                   20


<210> 25310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25310
agtattgtgt aaagttttta                                                   20


<210> 25311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25311
attataataa gtattgtgta                                                   20


<210> 25312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25312
tctataagga aaattataat                                                   20


<210> 25313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25313
gtataagtga gatctctata                                                   20


<210> 25314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25314
agtataagtg agatctctat                                                   20


<210> 25315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25315
aagattatca aagtataagt                                                   20


<210> 25316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25316
gaataagatt atcaaagtat                                                   20


<210> 25317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25317
atctaggaat aagattatca                                                   20


<210> 25318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25318
aatgtcaagt atctaggaat                                                   20


<210> 25319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25319
ttttaaaatg tcaagtatct                                                   20


<210> 25320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25320
attttaaaat gtcaagtatc                                                   20


<210> 25321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25321
cactggcatt ttaaaatgtc                                                   20


<210> 25322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25322
tttaaaaata ccatttacac                                                   20


<210> 25323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25323
cactagcaac aaacagaaaa                                                   20


<210> 25324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25324
gtatagacac tagcaacaaa                                                   20


<210> 25325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25325
aatcaattgt gtatagacac                                                   20


<210> 25326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25326
atacataaat caattgtgta                                                   20


<210> 25327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25327
aagagtatag taaggtagct                                                   20


<210> 25328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25328
aaagagtata gtaaggtagc                                                   20


<210> 25329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25329
aataaaagag tatagtaagg                                                   20


<210> 25330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25330
attaataaaa gagtatagta                                                   20


<210> 25331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25331
aattaataaa agagtatagt                                                   20


<210> 25332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25332
taagaattaa taaaagagta                                                   20


<210> 25333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25333
aacagtaaga attaataaaa                                                   20


<210> 25334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25334
taaacagtaa gaattaataa                                                   20


<210> 25335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25335
ataacctaga gataaacagt                                                   20


<210> 25336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25336
caacataacc tagagataaa                                                   20


<210> 25337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25337
aaaatatcca acataaccta                                                   20


<210> 25338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25338
ataaaatatc caacataacc                                                   20


<210> 25339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25339
agatgtaatt tacagataat                                                   20


<210> 25340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25340
agtaccgaag atgtaattta                                                   20


<210> 25341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25341
gcaagaagaa aaaagtaccg                                                   20


<210> 25342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25342
aaaaaagtgc aagaagaaaa                                                   20


<210> 25343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25343
aaagaaaaaa aaagtgcaag                                                   20


<210> 25344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25344
agcaaagaaa aaaaaagtgc                                                   20


<210> 25345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25345
tagtaaagca aagaaaaaaa                                                   20


<210> 25346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25346
tcagccagca tagtaaagca                                                   20


<210> 25347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25347
aggtctcagc cagcatagta                                                   20


<210> 25348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25348
aaaggaggtc tcagccagca                                                   20


<210> 25349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25349
tttgtaaagg aggtctcagc                                                   20


<210> 25350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25350
ccactttgta aaggaggtct                                                   20


<210> 25351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25351
tcagttccac tttgtaaagg                                                   20


<210> 25352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25352
ctcagttcca ctttgtaaag                                                   20


<210> 25353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25353
ttctcagttc cactttgtaa                                                   20


<210> 25354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25354
cttctcagtt ccactttgta                                                   20


<210> 25355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25355
ccaaagatgt ctgttcttct                                                   20


<210> 25356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25356
atcaaaagaa aaaaaaacca                                                   20


<210> 25357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25357
agctttccct ttgagatcaa                                                   20


<210> 25358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25358
acatggaaag ctttcccttt                                                   20


<210> 25359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25359
tacttaattg tgaacatgga                                                   20


<210> 25360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25360
gtcatactta attgtgaaca                                                   20


<210> 25361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25361
attcattgtt ttaaagtatc                                                   20


<210> 25362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25362
aaagggtatt cattgtttta                                                   20


<210> 25363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25363
gattgcatca ctctgataaa                                                   20


<210> 25364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25364
ggattgcatc actctgataa                                                   20


<210> 25365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25365
gggattgcat cactctgata                                                   20


<210> 25366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25366
agtataataa ttttaaaaag                                                   20


<210> 25367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25367
aagtataata attttaaaaa                                                   20


<210> 25368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25368
aaagtataat aattttaaaa                                                   20


<210> 25369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25369
taaagtataa taattttaaa                                                   20


<210> 25370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25370
cacatgtacc ccagaactta                                                   20


<210> 25371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25371
cacgttctgc acatgtaccc                                                   20


<210> 25372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 25372
ggtacaccta tgtaacaaac                                                   20


<210> 25373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25373
gcagcaaacc accatggcac                                                   20


<210> 25374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 25374
tgcagcaaac caccatggca                                                   20


<210> 25375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25375
aagggtgcag caaaccacca                                                   20


<210> 25376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25376
aaatgacggg ttgaagggtg                                                   20


<210> 25377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25377
aatgtaaatg acgggttgaa                                                   20


<210> 25378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25378
taatgtaaat gacgggttga                                                   20


<210> 25379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25379
ctaatgtaaa tgacgggttg                                                   20


<210> 25380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25380
aaatacctaa tgtaaatgac                                                   20


<210> 25381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 25381
gaaataccta atgtaaatga                                                   20


<210> 25382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25382
taggggaggg atagcattag                                                   20


<210> 25383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25383
gctaggggag ggatagcatt                                                   20


<210> 25384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25384
ggctagggga gggatagcat                                                   20


<210> 25385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25385
gtggggggct aggggaggga                                                   20


<210> 25386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25386
aggggtgggg ggctagggga                                                   20


<210> 25387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25387
gaggggtggg gggctagggg                                                   20


<210> 25388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25388
tgaggggtgg ggggctaggg                                                   20


<210> 25389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25389
gttgaggggt ggggggctag                                                   20


<210> 25390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25390
tgttgagggg tggggggcta                                                   20


<210> 25391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25391
ctgttgaggg gtggggggct                                                   20


<210> 25392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25392
cctgttgagg ggtggggggc                                                   20


<210> 25393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25393
ggggcctgtt gaggggtggg                                                   20


<210> 25394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25394
tggggcctgt tgaggggtgg                                                   20


<210> 25395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25395
ctggggcctg ttgaggggtg                                                   20


<210> 25396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25396
actggggcct gttgaggggt                                                   20


<210> 25397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25397
cactggggcc tgttgagggg                                                   20


<210> 25398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25398
acacactggg gcctgttgag                                                   20


<210> 25399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25399
aacacactgg ggcctgttga                                                   20


<210> 25400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25400
gaacacactg gggcctgttg                                                   20


<210> 25401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25401
ggaacacact ggggcctgtt                                                   20


<210> 25402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25402
acagggaggg gaacacactg                                                   20


<210> 25403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25403
cacagggagg ggaacacact                                                   20


<210> 25404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25404
acacagggag gggaacacac                                                   20


<210> 25405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25405
gaacacatgg acacagggag                                                   20


<210> 25406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25406
agaacacatg gacacaggga                                                   20


<210> 25407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25407
gagaacacat ggacacaggg                                                   20


<210> 25408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25408
tgagaacaca tggacacagg                                                   20


<210> 25409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25409
aatgagaaca catggacaca                                                   20


<210> 25410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25410
caatgagaac acatggacac                                                   20


<210> 25411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25411
acaatgagaa cacatggaca                                                   20


<210> 25412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25412
agttgaacaa tgagaacaca                                                   20


<210> 25413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25413
ataagtggga gttgaacaat                                                   20


<210> 25414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25414
atgttctcac tcataagtgg                                                   20


<210> 25415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25415
gtatgttctc actcataagt                                                   20


<210> 25416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25416
cgtatgttct cactcataag                                                   20


<210> 25417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25417
caccgtatgt tctcactcat                                                   20


<210> 25418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25418
tcagcaaact aacacaagaa                                                   20


<210> 25419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25419
cattctcagc aaactaacac                                                   20


<210> 25420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25420
aagctggaaa ccatcattct                                                   20


<210> 25421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25421
tgcagggaca tggatgaagc                                                   20


<210> 25422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25422
cctttgcagg gacatggatg                                                   20


<210> 25423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25423
tcatgtcctt tgcagggaca                                                   20


<210> 25424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25424
atgagttcat gtcctttgca                                                   20


<210> 25425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25425
gatgagttca tgtcctttgc                                                   20


<210> 25426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25426
ggatgagttc atgtcctttg                                                   20


<210> 25427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25427
atgcagtcat aaaaaaggat                                                   20


<210> 25428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25428
atgctatgca gtcataaaaa                                                   20


<210> 25429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25429
aatgctatgc agtcataaaa                                                   20


<210> 25430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25430
atacaccatg gaatgctatg                                                   20


<210> 25431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25431
aatgtggcac atatacacca                                                   20


<210> 25432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25432
gaaatagaag ggaataaatg                                                   20


<210> 25433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25433
ttagaaaagt tgaaatagaa                                                   20


<210> 25434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25434
cttagaaaag ttgaaataga                                                   20


<210> 25435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25435
tcttagaaaa gttgaaatag                                                   20


<210> 25436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25436
aattcttaga aaagttgaaa                                                   20


<210> 25437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25437
ataattttaa attcttagaa                                                   20


<210> 25438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25438
catttataat tttaaattct                                                   20


<210> 25439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25439
gatgctaaaa tcatttgata                                                   20


<210> 25440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25440
attaaaggaa aaggatcaca                                                   20


<210> 25441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25441
tattaataga ttaaaggaaa                                                   20


<210> 25442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25442
ttattaatag attaaaggaa                                                   20


<210> 25443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25443
tatttttatt aatagattaa                                                   20


<210> 25444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25444
atatttttat taatagatta                                                   20


<210> 25445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25445
atacgttata tttttattaa                                                   20


<210> 25446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25446
aacagtaatg catgccacaa                                                   20


<210> 25447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25447
tttttttttg ctaatcataa                                                   20


<210> 25448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25448
ataataacag gtgctttgca                                                   20


<210> 25449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25449
ttataataac aggtgctttg                                                   20


<210> 25450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25450
atacctttgg ttataataac                                                   20


<210> 25451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25451
catacctttg gttataataa                                                   20


<210> 25452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25452
gcttgaacct aacatacctt                                                   20


<210> 25453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25453
tgggagggat gcttccactc                                                   20


<210> 25454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25454
ccatatccac acatctggga                                                   20


<210> 25455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25455
tccatatcca cacatctggg                                                   20


<210> 25456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25456
ttccatatcc acacatctgg                                                   20


<210> 25457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25457
cattccatat ccacacatct                                                   20


<210> 25458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25458
acattccata tccacacatc                                                   20


<210> 25459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25459
cctatagttt cagaatctgg                                                   20


<210> 25460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25460
cccctatagt ttcagaatct                                                   20


<210> 25461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25461
acccctatag tttcagaatc                                                   20


<210> 25462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25462
gggtgaaacc cctatagttt                                                   20


<210> 25463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25463
gttagtgggt gaaaccccta                                                   20


<210> 25464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25464
ttctatttcc ctaggttagt                                                   20


<210> 25465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25465
attctatttc cctaggttag                                                   20


<210> 25466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25466
gttattctat ttccctaggt                                                   20


<210> 25467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25467
tgaagttatt ctatttccct                                                   20


<210> 25468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25468
ctgaagttat tctatttccc                                                   20


<210> 25469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25469
aagtaacctt agtattcctg                                                   20


<210> 25470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25470
catatgcctc aaagtaacct                                                   20


<210> 25471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25471
atcatgcttc atatgcctca                                                   20


<210> 25472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25472
actcataaat gaagctgttt                                                   20


<210> 25473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25473
tagaaaataa ctcataaatg                                                   20


<210> 25474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25474
aaatggctct ggagtatatt                                                   20


<210> 25475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25475
actaagaaca aatggctctg                                                   20


<210> 25476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25476
gaactaagaa caaatggctc                                                   20


<210> 25477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25477
gagacagaac taagaacaaa                                                   20


<210> 25478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25478
agcaaaactg agacagaact                                                   20


<210> 25479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25479
agacaggagc aaaactgaga                                                   20


<210> 25480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25480
agagagacag gagcaaaact                                                   20


<210> 25481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25481
ctgctatgaa agagagacag                                                   20


<210> 25482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25482
gcctgctatg aaagagagac                                                   20


<210> 25483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25483
ggcctgctat gaaagagaga                                                   20


<210> 25484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25484
agaaggcctg ctatgaaaga                                                   20


<210> 25485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25485
tgagaaggcc tgctatgaaa                                                   20


<210> 25486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25486
tttgagaagg cctgctatga                                                   20


<210> 25487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25487
gagaaggtat gcttttgaga                                                   20


<210> 25488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25488
agagaaggta tgcttttgag                                                   20


<210> 25489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25489
cttagagaag gtatgctttt                                                   20


<210> 25490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25490
acaaatgtat gccttagaga                                                   20


<210> 25491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25491
cacaaatgta tgccttagag                                                   20


<210> 25492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25492
acacacaaat gtatgcctta                                                   20


<210> 25493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25493
gcacacacaa atgtatgcct                                                   20


<210> 25494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25494
acacacactc actcacctgc                                                   20


<210> 25495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25495
ctaaggtggc ctgggaagat                                                   20


<210> 25496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25496
aaagtctaag gtggcctggg                                                   20


<210> 25497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25497
cagaaagtct aaggtggcct                                                   20


<210> 25498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25498
ccagaaagtc taaggtggcc                                                   20


<210> 25499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25499
cagccccaga aagtctaagg                                                   20


<210> 25500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25500
tcccagcccc agaaagtcta                                                   20


<210> 25501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25501
gtcccagccc cagaaagtct                                                   20


<210> 25502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25502
gcctgagtcc cagccccaga                                                   20


<210> 25503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25503
aaatgcctga gtcccagccc                                                   20


<210> 25504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25504
ttttttaaat gcctgagtcc                                                   20


<210> 25505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25505
gggagatttt ttaaatgcct                                                   20


<210> 25506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25506
tgcatattgc aatttttggg                                                   20


<210> 25507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25507
gctgcatatt gcaatttttg                                                   20


<210> 25508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25508
ggctgcatat tgcaattttt                                                   20


<210> 25509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25509
tggctgcata ttgcaatttt                                                   20


<210> 25510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25510
agattagtgg ttctcaactt                                                   20


<210> 25511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25511
ttcaaagaga tacagattag                                                   20


<210> 25512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25512
agtttcaaag agatacagat                                                   20


<210> 25513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25513
ttttcagttt caaagagata                                                   20


<210> 25514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25514
acatgatttt cagtttcaaa                                                   20


<210> 25515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25515
atacatgatt ttcagtttca                                                   20


<210> 25516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25516
tcataaacat acatgatttt                                                   20


<210> 25517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25517
aaccaggtct ctccttctgt                                                   20


<210> 25518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25518
tatatgtctt tgtaataacc                                                   20


<210> 25519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25519
ctatatgtct ttgtaataac                                                   20


<210> 25520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25520
tatcctgcca tgcctcatgt                                                   20


<210> 25521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25521
ttatcctgcc atgcctcatg                                                   20


<210> 25522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25522
tcttttcttc cttcacttgg                                                   20


<210> 25523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25523
ctttcttttc ttccttcact                                                   20


<210> 25524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25524
tccagagaaa attgagtgag                                                   20


<210> 25525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25525
ccttccagag aaaattgagt                                                   20


<210> 25526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25526
ctgaccttcc agagaaaatt                                                   20


<210> 25527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25527
tgacccgaac tgaccttcca                                                   20


<210> 25528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25528
catgacccga actgaccttc                                                   20


<210> 25529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25529
atttattacg gtcactattt                                                   20


<210> 25530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 25530
gtggttcagt ttatttatta                                                   20


<210> 25531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25531
cacaggcctt tcaggtggtt                                                   20


<210> 25532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25532
cttaacacag gcctttcagg                                                   20


<210> 25533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25533
ttccttaaca caggcctttc                                                   20


<210> 25534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25534
tttccttaac acaggccttt                                                   20


<210> 25535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25535
tctcagcttt tccttaacac                                                   20


<210> 25536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25536
atctcagctt ttccttaaca                                                   20


<210> 25537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25537
tcacagagac ttggtgatct                                                   20


<210> 25538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25538
tagatgacat cacagagact                                                   20


<210> 25539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25539
tgatcctaga tgacatcaca                                                   20


<210> 25540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25540
ggtgatccta gatgacatca                                                   20


<210> 25541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25541
attcagcatc aaggtgatcc                                                   20


<210> 25542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25542
aatgtaatca ttcagcatca                                                   20


<210> 25543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25543
gaatgtaatc attcagcatc                                                   20


<210> 25544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25544
gatttatgaa tgtaatcatt                                                   20


<210> 25545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25545
tcataaagct aatattggct                                                   20


<210> 25546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25546
caagatcata aagctaatat                                                   20


<210> 25547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25547
tattatgtga caagatcata                                                   20


<210> 25548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25548
gttagtggtt attatgtgac                                                   20


<210> 25549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25549
aggcactcag taaatgttag                                                   20


<210> 25550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25550
cttaggcact cagtaaatgt                                                   20


<210> 25551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25551
ctcagcctag cttaggcact                                                   20


<210> 25552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25552
caaagtactc agcctagctt                                                   20


<210> 25553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25553
acaaagtact cagcctagct                                                   20


<210> 25554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25554
catggacaaa gtactcagcc                                                   20


<210> 25555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25555
agtaacatgg acaaagtact                                                   20


<210> 25556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25556
tattagaagt aacatggaca                                                   20


<210> 25557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25557
cagttgtatt agaagtaaca                                                   20


<210> 25558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25558
ctgtagatca gttgtattag                                                   20


<210> 25559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25559
cacctgtaga tcagttgtat                                                   20


<210> 25560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25560
atttataccc acctgtagat                                                   20


<210> 25561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25561
tagatattta tacccacctg                                                   20


<210> 25562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25562
tgtttctcag cttcaaaatg                                                   20


<210> 25563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25563
ttttttgtca gcctgtttct                                                   20


<210> 25564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25564
atttaacttt tattttttgt                                                   20


<210> 25565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25565
ctagctgcat gacctgagaa                                                   20


<210> 25566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25566
gttgactagc tgcatgacct                                                   20


<210> 25567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25567
atctctgcag catggttgac                                                   20


<210> 25568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25568
gagttcacat ctctgcagca                                                   20


<210> 25569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25569
gataagagtt cacatctctg                                                   20


<210> 25570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25570
gtttgttatc aaacagataa                                                   20


<210> 25571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25571
gagtttgtta tcaaacagat                                                   20


<210> 25572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25572
gctcagagtt tgttatcaaa                                                   20


<210> 25573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25573
gtttccttct atcttgctca                                                   20


<210> 25574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25574
ctgtttcctt ctatcttgct                                                   20


<210> 25575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25575
gaaggacatt ttggaaaagg                                                   20


<210> 25576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25576
cagaaggaca ttttggaaaa                                                   20


<210> 25577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25577
gcagaaggac attttggaaa                                                   20


<210> 25578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25578
ggcagaagga cattttggaa                                                   20


<210> 25579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25579
ttcggggcag aaggacattt                                                   20


<210> 25580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25580
aatgaaggct tcggggcaga                                                   20


<210> 25581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25581
aaatgaaggc ttcggggcag                                                   20


<210> 25582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25582
ctgaaatgaa ggcttcgggg                                                   20


<210> 25583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25583
atactgaaat gaaggcttcg                                                   20


<210> 25584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25584
tatactgaaa tgaaggcttc                                                   20


<210> 25585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 25585
gtatactgaa atgaaggctt                                                   20


<210> 25586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25586
cattttgtat actgaaatga                                                   20


<210> 25587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25587
ccattttgta tactgaaatg                                                   20


<210> 25588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25588
catttgccag atgaaatttc                                                   20


<210> 25589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25589
acatttgcca gatgaaattt                                                   20


<210> 25590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25590
agaataaaaa agacatttgc                                                   20


<210> 25591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25591
ctttgtcttt tagaataaaa                                                   20


<210> 25592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25592
tctaactttt ctttgtcttt                                                   20


<210> 25593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25593
gtacctcttc acttatctcc                                                   20


<210> 25594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25594
gatgaaacta attcccatga                                                   20


<210> 25595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25595
cggtggaact gatctcaact                                                   20


<210> 25596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25596
ccagaagacc atttcctcgg                                                   20


<210> 25597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 25597
tacccagaag accatttcct                                                   20


<210> 25598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25598
cctccaccgt tcctacccag                                                   20


<210> 25599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25599
ctgcctccac cgttcctacc                                                   20


<210> 25600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25600
ttggggtttt cttcctgagc                                                   20


<210> 25601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25601
ctacttgggg ttttcttcct                                                   20


<210> 25602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25602
ctccagccta atcctacttg                                                   20


<210> 25603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25603
actccagcct aatcctactt                                                   20


<210> 25604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25604
cactccagcc taatcctact                                                   20


<210> 25605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25605
ctattcagag ttctccactc                                                   20


<210> 25606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25606
ttctccactc tagctattca                                                   20


<210> 25607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25607
tattctccac tctagctatt                                                   20


<210> 25608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25608
gctgtcaata ttctccactc                                                   20


<210> 25609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25609
tttgataatc cctttgccca                                                   20


<210> 25610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25610
aagtgggaac aatttacctt                                                   20


<210> 25611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25611
cctaagaaaa atgtccaagt                                                   20


<210> 25612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25612
tcctaagaaa aatgtccaag                                                   20


<210> 25613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25613
tattcctaag aaaaatgtcc                                                   20


<210> 25614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25614
ttgggagccc agctattcct                                                   20


<210> 25615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25615
aggaagcact gttgggagcc                                                   20


<210> 25616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25616
tccttaggaa gcactgttgg                                                   20


<210> 25617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25617
tttccttagg aagcactgtt                                                   20


<210> 25618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25618
ttttccttag gaagcactgt                                                   20


<210> 25619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25619
aagttttatt tttccttagg                                                   20


<210> 25620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25620
ttcaagtttt atttttcctt                                                   20


<210> 25621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25621
cttcaagttt tatttttcct                                                   20


<210> 25622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25622
tgtaggtcaa gtttatcttc                                                   20


<210> 25623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25623
ttgtactctc tctgtaggtc                                                   20


<210> 25624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25624
gagtgttgta ctctctctgt                                                   20


<210> 25625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25625
tgagtgttgt actctctctg                                                   20


<210> 25626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25626
ttctgctcaa attgaaaaat                                                   20


<210> 25627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25627
tagacacatc aaggcattta                                                   20


<210> 25628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25628
ctgtaaaact agacacatca                                                   20


<210> 25629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25629
actgtaaaac tagacacatc                                                   20


<210> 25630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25630
ttcctaagta actgtaaaac                                                   20


<210> 25631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25631
ttcataatag atgtgttcct                                                   20


<210> 25632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25632
tagaattttc cttttcataa                                                   20


<210> 25633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25633
ggaaaatgtg gtttaattaa                                                   20


<210> 25634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25634
tgtaagtcag caggaaaatg                                                   20


<210> 25635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25635
taatttaatt gtaagtcagc                                                   20


<210> 25636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25636
ttaatttaat tgtaagtcag                                                   20


<210> 25637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25637
ttcttaattt aattgtaagt                                                   20


<210> 25638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25638
atatttctta atttaattgt                                                   20


<210> 25639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25639
attaacattt ccccccatgt                                                   20


<210> 25640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25640
cacgatttta gtttaatcct                                                   20


<210> 25641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25641
tagaattgga gacacgattt                                                   20


<210> 25642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25642
tttaaatatt tgtagaattg                                                   20


<210> 25643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25643
cttttaaata tttgtagaat                                                   20


<210> 25644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25644
atattacttt taaatatttg                                                   20


<210> 25645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25645
tcataactaa tattatacat                                                   20


<210> 25646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25646
aaaagatact agaattctca                                                   20


<210> 25647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25647
caaaagatac tagaattctc                                                   20


<210> 25648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25648
ccaaaagata ctagaattct                                                   20


<210> 25649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25649
actccagccc caaaagatac                                                   20


<210> 25650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25650
tttggtaact ccagccccaa                                                   20


<210> 25651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25651
tctcataaat ttggtaactc                                                   20


<210> 25652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25652
gcatttaaat ctcataaatt                                                   20


<210> 25653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25653
agggggtctc ttcctcacaa                                                   20


<210> 25654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25654
ggacagaaaa gctgttgagg                                                   20


<210> 25655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25655
tggacagaaa agctgttgag                                                   20


<210> 25656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25656
ctggacagaa aagctgttga                                                   20


<210> 25657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25657
gctggacaga aaagctgttg                                                   20


<210> 25658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25658
agctggacag aaaagctgtt                                                   20


<210> 25659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25659
agagtcacag ctggacagaa                                                   20


<210> 25660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25660
ttggtagagt cacagctgga                                                   20


<210> 25661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25661
ttgcttggta gagtcacagc                                                   20


<210> 25662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25662
ataattgctt ggtagagtca                                                   20


<210> 25663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25663
gagtaaataa ttgcttggta                                                   20


<210> 25664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25664
atgagtaaat aattgcttgg                                                   20


<210> 25665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25665
ttgatgagta aataattgct                                                   20


<210> 25666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25666
tcttcatctt gagatttgat                                                   20


<210> 25667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25667
gtgaatattc tcttcatctt                                                   20


<210> 25668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25668
cctaaaaaga accaagtgac                                                   20


<210> 25669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25669
aaaatcccct aaaaagaacc                                                   20


<210> 25670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25670
tagaaataaa atcccctaaa                                                   20


<210> 25671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25671
ataagtaaga aacagctaat                                                   20


<210> 25672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25672
acatctggat aagtaagaaa                                                   20


<210> 25673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25673
tgaattacat ctggataagt                                                   20


<210> 25674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25674
tggttgaatt acatctggat                                                   20


<210> 25675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25675
gattctggtt gaattacatc                                                   20


<210> 25676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25676
aaactcctct ttatggattc                                                   20


<210> 25677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25677
aacatacaaa ctcctcttta                                                   20


<210> 25678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25678
acatggaaat tacaaataaa                                                   20


<210> 25679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25679
ttacatggaa attacaaata                                                   20


<210> 25680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25680
tcaaaatata tacaattaca                                                   20


<210> 25681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25681
atgtgtcgtc tctgcttggg                                                   20


<210> 25682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25682
tcaatgtgtc gtctctgctt                                                   20


<210> 25683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25683
ctcaatgtgt cgtctctgct                                                   20


<210> 25684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25684
agtagggtgg aaagtaatca                                                   20


<210> 25685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25685
aagtagggtg gaaagtaatc                                                   20


<210> 25686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25686
gaagtagggt ggaaagtaat                                                   20


<210> 25687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25687
cagtgaggaa gtagggtgga                                                   20


<210> 25688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25688
tctacagtga ggaagtaggg                                                   20


<210> 25689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25689
gtatctacag tgaggaagta                                                   20


<210> 25690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25690
agtatctaca gtgaggaagt                                                   20


<210> 25691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25691
cagtatctac agtgaggaag                                                   20


<210> 25692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25692
gagcagtatc tacagtgagg                                                   20


<210> 25693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25693
gtagagcagt atctacagtg                                                   20


<210> 25694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25694
cgtagagcag tatctacagt                                                   20


<210> 25695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25695
cctgcgtaga gcagtatcta                                                   20


<210> 25696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25696
agcctgcatc ctgcgtagag                                                   20


<210> 25697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25697
tccagcctgc atcctgcgta                                                   20


<210> 25698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25698
agtccagcct gcatcctgcg                                                   20


<210> 25699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25699
atgtagctag ttaagaagtc                                                   20


<210> 25700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25700
agaccatgta gctagttaag                                                   20


<210> 25701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25701
ccaagaccat gtagctagtt                                                   20


<210> 25702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25702
attatccaag accatgtagc                                                   20


<210> 25703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25703
gtaaattatc caagaccatg                                                   20


<210> 25704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25704
aggcattaag taaattatcc                                                   20


<210> 25705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25705
aactgacaca cagaggcatt                                                   20


<210> 25706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25706
ataatgaaac tgacacacag                                                   20


<210> 25707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25707
gataatgaaa ctgacacaca                                                   20


<210> 25708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25708
cagataatga aactgacaca                                                   20


<210> 25709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25709
agattaccat ccccatttta                                                   20


<210> 25710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25710
gttcaaaagc ctctgaagta                                                   20


<210> 25711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25711
cagttcaaaa gcctctgaag                                                   20


<210> 25712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25712
catcagttca aaagcctctg                                                   20


<210> 25713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25713
caataccatc atcagttcaa                                                   20


<210> 25714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25714
ctaagtgtca ataccatcat                                                   20


<210> 25715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25715
tcacttgcta aatacttcct                                                   20


<210> 25716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25716
aaggatattt aatgacaata                                                   20


<210> 25717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25717
gaattttcag attctacaga                                                   20


<210> 25718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25718
tgaattttca gattctacag                                                   20


<210> 25719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25719
tcttgaattt tcagattcta                                                   20


<210> 25720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25720
tgagctgaat cttgaatttt                                                   20


<210> 25721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25721
cagcaagaat tacgttttct                                                   20


<210> 25722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25722
tttctttctg gctggccagc                                                   20


<210> 25723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25723
tttttttctt tctggctggc                                                   20


<210> 25724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25724
tacatttttt tctttctggc                                                   20


<210> 25725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25725
tttttacatt tttttctttc                                                   20


<210> 25726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25726
tgaagctgca cagcttgatg                                                   20


<210> 25727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25727
acactcaaca tgaagctgca                                                   20


<210> 25728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25728
ctatctgcac actcaacatg                                                   20


<210> 25729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25729
ttgagctggt aaccttggca                                                   20


<210> 25730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25730
tgtcattgag ctggtaacct                                                   20


<210> 25731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25731
ctggacagtt gtcattgagc                                                   20


<210> 25732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25732
atttctggac agttgtcatt                                                   20


<210> 25733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25733
cagattgttg gatttctgga                                                   20


<210> 25734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25734
gaggcagatt gttggatttc                                                   20


<210> 25735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25735
ctaactctga ggcagattgt                                                   20


<210> 25736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25736
cctgctccct aactctgagg                                                   20


<210> 25737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25737
taccctgctc cctaactctg                                                   20


<210> 25738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25738
ctaccctgct ccctaactct                                                   20


<210> 25739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25739
tagaaggctt cagtaaaaaa                                                   20


<210> 25740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25740
cttagaaggc ttcagtaaaa                                                   20


<210> 25741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25741
agccttttct tagaaggctt                                                   20


<210> 25742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25742
gtaaccagcc ttttcttaga                                                   20


<210> 25743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25743
ggtaaccagc cttttcttag                                                   20


<210> 25744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25744
aatggtaacc agccttttct                                                   20


<210> 25745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25745
gttgcctgac aaatggtaac                                                   20


<210> 25746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25746
tgcctcagtt gcctgacaaa                                                   20


<210> 25747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25747
gtacaagaat acacctgcct                                                   20


<210> 25748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25748
cttgcaggag gttgatgtac                                                   20


<210> 25749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25749
atttagccct ggcttgcagg                                                   20


<210> 25750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25750
aatttagccc tggcttgcag                                                   20


<210> 25751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25751
caaatttagc cctggcttgc                                                   20


<210> 25752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25752
acaaatttag ccctggcttg                                                   20


<210> 25753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25753
ctttatgaca aatttagccc                                                   20


<210> 25754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25754
gaagttcttt atgacaaatt                                                   20


<210> 25755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25755
ttggtcatcg gaaggattgg                                                   20


<210> 25756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25756
tccttggtca tcggaaggat                                                   20


<210> 25757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25757
taagatcctt ggtcatcgga                                                   20


<210> 25758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25758
ctaagatcct tggtcatcgg                                                   20


<210> 25759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 25759
gacctaagat ccttggtcat                                                   20


<210> 25760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25760
tcctaatgac ctaagatcct                                                   20


<210> 25761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25761
tggaaagatc ctaatgacct                                                   20


<210> 25762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25762
tcctgggtga tcctaatgga                                                   20


<210> 25763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25763
atcttcctgg gtgatcctaa                                                   20


<210> 25764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25764
tggtttccta agatcttcct                                                   20


<210> 25765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25765
ttggtttcct aagatcttcc                                                   20


<210> 25766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25766
atactttggt ttggtttcct                                                   20


<210> 25767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25767
agaaaaaaga tactttggtt                                                   20


<210> 25768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25768
ctagtagaaa aaagatactt                                                   20


<210> 25769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25769
caagccaaac tagtagaaaa                                                   20


<210> 25770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25770
tgcaaggcaa gccaaactag                                                   20


<210> 25771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25771
ttttgcaagg caagccaaac                                                   20


<210> 25772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25772
ttcaggggat tttgcaaggc                                                   20


<210> 25773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25773
tgctttcagg ggattttgca                                                   20


<210> 25774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25774
ctgctttcag gggattttgc                                                   20


<210> 25775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25775
atgtcagaag ctgctttcag                                                   20


<210> 25776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25776
aatgtcagaa gctgctttca                                                   20


<210> 25777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25777
taatgtcaga agctgctttc                                                   20


<210> 25778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25778
gtaatgtcag aagctgcttt                                                   20


<210> 25779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25779
attgttttag gtaatgtcag                                                   20


<210> 25780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25780
tgaattgttt taggtaatgt                                                   20


<210> 25781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25781
tctactatat gaattgtttt                                                   20


<210> 25782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25782
gtctactata tgaattgttt                                                   20


<210> 25783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25783
tgtaatgatt agagacacat                                                   20


<210> 25784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25784
atacaagact gtaatgatta                                                   20


<210> 25785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25785
ccatacaaga ctgtaatgat                                                   20


<210> 25786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25786
atctgatgtt catgccatac                                                   20


<210> 25787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25787
attactcaaa aactactagc                                                   20


<210> 25788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25788
aattactcaa aaactactag                                                   20


<210> 25789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25789
acaaattact caaaaactac                                                   20


<210> 25790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25790
atgggacctc attggtcatg                                                   20


<210> 25791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25791
aatgggacct cattggtcat                                                   20


<210> 25792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25792
caatgggacc tcattggtca                                                   20


<210> 25793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25793
tagtctcaat gggacctcat                                                   20


<210> 25794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25794
agagcacaca tagtctcaat                                                   20


<210> 25795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25795
aagagcacac atagtctcaa                                                   20


<210> 25796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25796
catgatggga agagcacaca                                                   20


<210> 25797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25797
aaaacagacc atgatgggaa                                                   20


<210> 25798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25798
ggaaaacaga ccatgatggg                                                   20


<210> 25799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25799
caaggaaaac agaccatgat                                                   20


<210> 25800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25800
gcaaggaaaa cagaccatga                                                   20


<210> 25801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25801
ctcccagagg gcaaggaaaa                                                   20


<210> 25802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25802
gcagcacctc ccagagggca                                                   20


<210> 25803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25803
agcagcacct cccagagggc                                                   20


<210> 25804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25804
aaagagcagc acctcccaga                                                   20


<210> 25805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25805
aaaagagcag cacctcccag                                                   20


<210> 25806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25806
caaaagagca gcacctccca                                                   20


<210> 25807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25807
ggcaaaagag cagcacctcc                                                   20


<210> 25808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25808
ctgcttactg ggcaaaagag                                                   20


<210> 25809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25809
tggctgctta ctgggcaaaa                                                   20


<210> 25810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25810
agtggctgct tactgggcaa                                                   20


<210> 25811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25811
ctgagaagtg gctgcttact                                                   20


<210> 25812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25812
gctgagaagt ggctgcttac                                                   20


<210> 25813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25813
gccatagcca tgctgagaag                                                   20


<210> 25814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25814
tgtgccatag ccatgctgag                                                   20


<210> 25815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25815
ctctgtgcca tagccatgct                                                   20


<210> 25816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25816
tgagttgttg ctctgtgcca                                                   20


<210> 25817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25817
tgggcagatg agataggcat                                                   20


<210> 25818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25818
cttctttggg cagatgagat                                                   20


<210> 25819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25819
ccttctttgg gcagatgaga                                                   20


<210> 25820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25820
caagccttct ttgggcagat                                                   20


<210> 25821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25821
gggcccaagc cttctttggg                                                   20


<210> 25822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25822
agagggccca agccttcttt                                                   20


<210> 25823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25823
aagagggccc aagccttctt                                                   20


<210> 25824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25824
aacaggcagt aagagggccc                                                   20


<210> 25825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25825
caacacaaca ggcagtaaga                                                   20


<210> 25826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25826
acaacacaac aggcagtaag                                                   20


<210> 25827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25827
cacaacacaa caggcagtaa                                                   20


<210> 25828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25828
cccacaacac aacaggcagt                                                   20


<210> 25829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25829
tttccccaca acacaacagg                                                   20


<210> 25830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25830
cgctttcccc acaacacaac                                                   20


<210> 25831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25831
ccgctttccc cacaacacaa                                                   20


<210> 25832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25832
cacattctca ccacggtgtg                                                   20


<210> 25833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 25833
ccccagacac attctcacca                                                   20


<210> 25834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25834
gggaggtttg ctgatgcccc                                                   20


<210> 25835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25835
aacatcctct ttatgagggg                                                   20


<210> 25836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25836
aaacatcctc tttatgaggg                                                   20


<210> 25837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25837
aaaaacatcc tctttatgag                                                   20


<210> 25838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25838
gaaaaacatc ctctttatga                                                   20


<210> 25839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25839
tgaaaaacat cctctttatg                                                   20


<210> 25840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25840
ttgaaaaaca tcctctttat                                                   20


<210> 25841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25841
gactaatcta gacacacctg                                                   20


<210> 25842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25842
ggattcacct cagactaatc                                                   20


<210> 25843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25843
caggtggttt ggattcacct                                                   20


<210> 25844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25844
tatgcaacac acaggtggtt                                                   20


<210> 25845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25845
gtgtttatgc aacacacagg                                                   20


<210> 25846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25846
gaagtgttta tgcaacacac                                                   20


<210> 25847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25847
agaagtgttt atgcaacaca                                                   20


<210> 25848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25848
gcagtcccaa gacacagaag                                                   20


<210> 25849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25849
aaagcagtcc caagacacag                                                   20


<210> 25850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25850
cccaaagcag tcccaagaca                                                   20


<210> 25851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25851
ccacacccca aagcagtccc                                                   20


<210> 25852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25852
atgtgtccca caccccaaag                                                   20


<210> 25853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25853
ttaatgtgtc ccacacccca                                                   20


<210> 25854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25854
ttagattgaa aaaatggctt                                                   20


<210> 25855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25855
attagattga aaaaatggct                                                   20


<210> 25856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25856
aggtcattag attgaaaaaa                                                   20


<210> 25857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25857
caaaagtaca atgaggtcat                                                   20


<210> 25858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25858
tgaatcccaa aagtacaatg                                                   20


<210> 25859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25859
ttgaatccca aaagtacaat                                                   20


<210> 25860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25860
cttatccaat tgaatcccaa                                                   20


<210> 25861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25861
ttctttagag gttagcaaca                                                   20


<210> 25862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25862
ccttctttag aggttagcaa                                                   20


<210> 25863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25863
ccagtacctt ctttagaggt                                                   20


<210> 25864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25864
gtgtccagta ccttctttag                                                   20


<210> 25865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25865
tgtgtccagt accttcttta                                                   20


<210> 25866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25866
actgtgtcca gtaccttctt                                                   20


<210> 25867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25867
tagaccttgc ctactgtgtc                                                   20


<210> 25868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25868
cctcttccac gtgttacaat                                                   20


<210> 25869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25869
gatcagaaga acggccatca                                                   20


<210> 25870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 25870
tttcaacctg atcagaagaa                                                   20


<210> 25871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25871
agtcctttca acctgatcag                                                   20


<210> 25872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25872
ttcagtcctt tcaacctgat                                                   20


<210> 25873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25873
actcgggccc tgtggctatt                                                   20


<210> 25874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25874
ttagtgccac tcgggccctg                                                   20


<210> 25875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25875
ttcccggttt agtgccactc                                                   20


<210> 25876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 25876
tttcccggtt tagtgccact                                                   20


<210> 25877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25877
gggaggacca tttcccggtt                                                   20


<210> 25878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 25878
acaaagggag gaccatttcc                                                   20


<210> 25879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25879
ttatggtgct gaacaaaggg                                                   20


<210> 25880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25880
tttatggtgc tgaacaaagg                                                   20


<210> 25881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25881
catttatggt gctgaacaaa                                                   20


<210> 25882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25882
acatttatgg tgctgaacaa                                                   20


<210> 25883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25883
gacatttatg gtgctgaaca                                                   20


<210> 25884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25884
tgttttgttt cagacattta                                                   20


<210> 25885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25885
ctttctgttt tgttttgttt                                                   20


<210> 25886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25886
ggaatcttgt ttctcattgg                                                   20


<210> 25887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25887
aggaatcttg tttctcattg                                                   20


<210> 25888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25888
taaggaatct tgtttctcat                                                   20


<210> 25889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25889
tttaaaaaca tggttgtata                                                   20


<210> 25890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25890
gtttaaaaac atggttgtat                                                   20


<210> 25891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25891
gcctctcatg tttaaaaaca                                                   20


<210> 25892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25892
cccttcttgc tcataagcct                                                   20


<210> 25893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25893
ccagagccct tcttgctcat                                                   20


<210> 25894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25894
tcattgacct gtagttccca                                                   20


<210> 25895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25895
tctcattgac ctgtagttcc                                                   20


<210> 25896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25896
atttgactct cattgacctg                                                   20


<210> 25897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25897
gagggtgagg atatggcttt                                                   20


<210> 25898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25898
ttgctgagag ggtgaggata                                                   20


<210> 25899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25899
aggatcttgc tgagagggtg                                                   20


<210> 25900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25900
gaggatcttg ctgagagggt                                                   20


<210> 25901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25901
agatgaggat cttgctgaga                                                   20


<210> 25902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25902
gagatgagga tcttgctgag                                                   20


<210> 25903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25903
agagatgagg atcttgctga                                                   20


<210> 25904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25904
ccagagatga ggatcttgct                                                   20


<210> 25905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25905
cactgtcagt cccagagatg                                                   20


<210> 25906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25906
gcactgtcag tcccagagat                                                   20


<210> 25907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25907
ttggtgcact gtcagtccca                                                   20


<210> 25908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25908
tcttggtgca ctgtcagtcc                                                   20


<210> 25909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25909
ggctcatctt ggtgcactgt                                                   20


<210> 25910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25910
taccctcagt gggctcatct                                                   20


<210> 25911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25911
tccattaaag taccctcagt                                                   20


<210> 25912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25912
gtccattaaa gtaccctcag                                                   20


<210> 25913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25913
tctgtccatt aaagtaccct                                                   20


<210> 25914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25914
gattggctgt ctgtccatta                                                   20


<210> 25915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25915
cctcttacca gcctgaggat                                                   20


<210> 25916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25916
taacacctct taccagcctg                                                   20


<210> 25917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25917
ataacacctc ttaccagcct                                                   20


<210> 25918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25918
ctgggcataa cacctcttac                                                   20


<210> 25919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25919
tgttgccaga gtcctcccct                                                   20


<210> 25920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25920
ctgttgccag agtcctcccc                                                   20


<210> 25921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25921
acttcaccat cctgttgcca                                                   20


<210> 25922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25922
taacttcacc atcctgttgc                                                   20


<210> 25923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25923
ggatggttct cttgtcagaa                                                   20


<210> 25924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25924
aaggatggtt ctcttgtcag                                                   20


<210> 25925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25925
aacaaggatg gttctcttgt                                                   20


<210> 25926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25926
gaaacattac aaaacaagga                                                   20


<210> 25927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25927
agaagaaaca ttacaaaaca                                                   20


<210> 25928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25928
cagaagaaac attacaaaac                                                   20


<210> 25929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25929
gatgtagaag gtggagacag                                                   20


<210> 25930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25930
agagatgtag aaggtggaga                                                   20


<210> 25931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25931
agacagagat gtagaaggtg                                                   20


<210> 25932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25932
agagacagag atgtagaagg                                                   20


<210> 25933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25933
ttaagagaca gagatgtaga                                                   20


<210> 25934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25934
tttaagagac agagatgtag                                                   20


<210> 25935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25935
ggatttaaga gacagagatg                                                   20


<210> 25936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25936
aggagaggat ttaagagaca                                                   20


<210> 25937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25937
ccaggagagg atttaagaga                                                   20


<210> 25938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25938
gaaaccagga gaggatttaa                                                   20


<210> 25939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25939
gagaaaccag gagaggattt                                                   20


<210> 25940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25940
tcagagggag aaaccaggag                                                   20


<210> 25941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25941
ctcagaggga gaaaccagga                                                   20


<210> 25942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25942
tcctcagagg gagaaaccag                                                   20


<210> 25943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25943
aatcctcaga gggagaaacc                                                   20


<210> 25944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25944
aaatcctcag agggagaaac                                                   20


<210> 25945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25945
tcctcctaaa tcctcagagg                                                   20


<210> 25946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25946
tatcctccta aatcctcaga                                                   20


<210> 25947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25947
atatcctcct aaatcctcag                                                   20


<210> 25948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25948
catatcctcc taaatcctca                                                   20


<210> 25949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25949
ttcatatcct cctaaatcct                                                   20


<210> 25950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25950
ttcctcctct cccatgccaa                                                   20


<210> 25951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25951
tcttcctcct ctcccatgcc                                                   20


<210> 25952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25952
ggctagcaga gtaaataaaa                                                   20


<210> 25953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25953
tggctagcag agtaaataaa                                                   20


<210> 25954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25954
catctcaaat atggctagca                                                   20


<210> 25955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25955
gccatctcaa atatggctag                                                   20


<210> 25956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25956
tcagccatct caaatatggc                                                   20


<210> 25957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25957
ggaatcagcc atctcaaata                                                   20


<210> 25958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25958
ggagttagga ggacaggaat                                                   20


<210> 25959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25959
tgtttgggag ttaggaggac                                                   20


<210> 25960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25960
atgtttggga gttaggagga                                                   20


<210> 25961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25961
atgcatgttt gggagttagg                                                   20


<210> 25962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25962
aatgcatgtt tgggagttag                                                   20


<210> 25963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25963
tgaatgcatg tttgggagtt                                                   20


<210> 25964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25964
gtgaatgcat gtttgggagt                                                   20


<210> 25965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25965
aatggtgaat gcatgtttgg                                                   20


<210> 25966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25966
aaaatggtga atgcatgttt                                                   20


<210> 25967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25967
aaaaatggtg aatgcatgtt                                                   20


<210> 25968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25968
atgttctacg agccaaaaaa                                                   20


<210> 25969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25969
ttgtattttt gatgttctac                                                   20


<210> 25970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25970
agaatcagta gtttaaacaa                                                   20


<210> 25971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25971
tgagaatcag tagtttaaac                                                   20


<210> 25972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25972
tcaaaaagtt tgagaatcag                                                   20


<210> 25973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 25973
aaatcaaaaa gtttgagaat                                                   20


<210> 25974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25974
tccctgaaat caaaaagttt                                                   20


<210> 25975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25975
taataatccc tgaaatcaaa                                                   20


<210> 25976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25976
gggtcctcaa taaggtttga                                                   20


<210> 25977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25977
tggggtcctc aataaggttt                                                   20


<210> 25978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25978
gttatttggg gtcctcaata                                                   20


<210> 25979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25979
agttatttgg ggtcctcaat                                                   20


<210> 25980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25980
acataaacaa aagttatttg                                                   20


<210> 25981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25981
aacataaaca aaagttattt                                                   20


<210> 25982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25982
caacataaac aaaagttatt                                                   20


<210> 25983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25983
aaaggtatca acataaacaa                                                   20


<210> 25984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25984
tatatctggc ataaacaaaa                                                   20


<210> 25985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25985
atatatctgg cataaacaaa                                                   20


<210> 25986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25986
taatatgata tacatatatc                                                   20


<210> 25987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25987
ttatgtatat ataggtatat                                                   20


<210> 25988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 25988
gtagctagtt atgtatatat                                                   20


<210> 25989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25989
tgtagctagt tatgtatata                                                   20


<210> 25990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25990
atacaactag accatgtagc                                                   20


<210> 25991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25991
atacatacaa ctagaccatg                                                   20


<210> 25992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 25992
actatgtata tacatacaac                                                   20


<210> 25993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25993
gagttttgaa tttctaatat                                                   20


<210> 25994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 25994
cccgtgtttt aaaatttcct                                                   20


<210> 25995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 25995
gtcatcactc taaaagctac                                                   20


<210> 25996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 25996
ggatgatgtc atcactctaa                                                   20


<210> 25997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25997
aatatagagg ctattgatgg                                                   20


<210> 25998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25998
gaatatagag gctattgatg                                                   20


<210> 25999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 25999
tgaatataga ggctattgat                                                   20


<210> 26000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26000
gtgaatatag aggctattga                                                   20


<210> 26001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26001
tcatacattg gtgaatatag                                                   20


<210> 26002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26002
atcatacatt ggtgaatata                                                   20


<210> 26003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26003
tgatcataca ttggtgaata                                                   20


<210> 26004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26004
tttctcttat gatcatacat                                                   20


<210> 26005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26005
aactattgta taacaatact                                                   20


<210> 26006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26006
gtccccaaaa ctgttttagt                                                   20


<210> 26007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26007
tgtccccaaa actgttttag                                                   20


<210> 26008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26008
tggtgtcccc aaaactgttt                                                   20


<210> 26009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26009
aactatgatc ttggaacccc                                                   20


<210> 26010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26010
gtggtcctca actatgatct                                                   20


<210> 26011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26011
gcaggatgaa tttaagccag                                                   20


<210> 26012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26012
aaagcaggat gaatttaagc                                                   20


<210> 26013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26013
acagaaagca ggatgaattt                                                   20


<210> 26014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26014
tggcggtgag gacagaaagc                                                   20


<210> 26015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26015
atggcggtga ggacagaaag                                                   20


<210> 26016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26016
agcatggcgg tgaggacaga                                                   20


<210> 26017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26017
gaggagcatg gcggtgagga                                                   20


<210> 26018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26018
gggggaggag catggcggtg                                                   20


<210> 26019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26019
tgggggagga gcatggcggt                                                   20


<210> 26020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 26020
aggttggggg aggagcatgg                                                   20


<210> 26021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26021
ttgaggttgg gggaggagca                                                   20


<210> 26022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26022
acatcttgag gttgggggag                                                   20


<210> 26023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26023
agacatcttg aggttggggg                                                   20


<210> 26024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26024
cagacatctt gaggttgggg                                                   20


<210> 26025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26025
agcagacatc ttgaggttgg                                                   20


<210> 26026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26026
gagcagacat cttgaggttg                                                   20


<210> 26027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26027
agagcagaca tcttgaggtt                                                   20


<210> 26028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26028
gagagcagac atcttgaggt                                                   20


<210> 26029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26029
ggtggagagc agacatcttg                                                   20


<210> 26030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26030
aggtggagag cagacatctt                                                   20


<210> 26031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26031
gtctctttgc aggtggagag                                                   20


<210> 26032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26032
tgggtctctt tgcaggtgga                                                   20


<210> 26033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26033
gttgggtctc tttgcaggtg                                                   20


<210> 26034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26034
gagttgggtc tctttgcagg                                                   20


<210> 26035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26035
gaggagttgg gtctctttgc                                                   20


<210> 26036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26036
agaggagttg ggtctctttg                                                   20


<210> 26037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26037
ctggggcctc cagaggagtt                                                   20


<210> 26038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26038
cctggggcct ccagaggagt                                                   20


<210> 26039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26039
ctggcctggg gcctccagag                                                   20


<210> 26040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26040
ctctggcctg gggcctccag                                                   20


<210> 26041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26041
cctctggcct ggggcctcca                                                   20


<210> 26042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26042
gacctctggc ctggggcctc                                                   20


<210> 26043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26043
cttggatgac ctctggcctg                                                   20


<210> 26044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26044
ccttggatga cctctggcct                                                   20


<210> 26045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26045
cccttggatg acctctggcc                                                   20


<210> 26046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26046
ctgttccctt ggatgacctc                                                   20


<210> 26047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26047
gggaaagttg gctgttccct                                                   20


<210> 26048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26048
gcagagcttt cagggaaagt                                                   20


<210> 26049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26049
tgctgcagag ctttcaggga                                                   20


<210> 26050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26050
taactgctgc agagctttca                                                   20


<210> 26051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26051
ataactgctg cagagctttc                                                   20


<210> 26052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26052
gataactgct gcagagcttt                                                   20


<210> 26053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26053
aaaagcagat aactgctgca                                                   20


<210> 26054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26054
tcaaaagcag ataactgctg                                                   20


<210> 26055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26055
taaacccaca tcttcaaaag                                                   20


<210> 26056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26056
aactaaaccc acatcttcaa                                                   20


<210> 26057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26057
aatttttatg acatttatga                                                   20


<210> 26058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26058
ggtgatgtgg cagtctgcta                                                   20


<210> 26059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26059
cttggccctg ggtgatgtgg                                                   20


<210> 26060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26060
ctccttggcc ctgggtgatg                                                   20


<210> 26061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26061
agaaagtcct ccttggccct                                                   20


<210> 26062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26062
cagaaagtcc tccttggccc                                                   20


<210> 26063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26063
ccagcccaga aagtcctcct                                                   20


<210> 26064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26064
tcggtcccac ccagcccaga                                                   20


<210> 26065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26065
agtctcggtc ccacccagcc                                                   20


<210> 26066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26066
gaggaagtct cggtcccacc                                                   20


<210> 26067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 26067
agctcttgga gaggaagtct                                                   20


<210> 26068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26068
gctctcagct cttggagagg                                                   20


<210> 26069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26069
tctgctctca gctcttggag                                                   20


<210> 26070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26070
gtctgctctc agctcttgga                                                   20


<210> 26071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26071
atgtctgctc tcagctcttg                                                   20


<210> 26072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26072
gaatgtctgc tctcagctct                                                   20


<210> 26073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26073
ctagtaggaa tgtctgctct                                                   20


<210> 26074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26074
accgggtaag agctactagt                                                   20


<210> 26075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26075
caccgggtaa gagctactag                                                   20


<210> 26076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26076
acacaccggg taagagctac                                                   20


<210> 26077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26077
ctacagcaca caccgggtaa                                                   20


<210> 26078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26078
ttctacagca cacaccgggt                                                   20


<210> 26079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26079
tccgttctac agcacacacc                                                   20


<210> 26080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 26080
atccgttcta cagcacacac                                                   20


<210> 26081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26081
gaggatctag atccgttcta                                                   20


<210> 26082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26082
cggggagccc ctggaggatc                                                   20


<210> 26083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26083
actgatcggg gagcccctgg                                                   20


<210> 26084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26084
aactgatcgg ggagcccctg                                                   20


<210> 26085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26085
agaactgatc ggggagcccc                                                   20


<210> 26086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26086
tcccagcaga actgatcggg                                                   20


<210> 26087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26087
gctcccagca gaactgatcg                                                   20


<210> 26088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26088
agctcccagc agaactgatc                                                   20


<210> 26089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 26089
gagctcccag cagaactgat                                                   20


<210> 26090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26090
gttctatggt gagctcccag                                                   20


<210> 26091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26091
caagttctat ggtgagctcc                                                   20


<210> 26092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26092
agctgcccaa gttctatggt                                                   20


<210> 26093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26093
aaccagctgc ccaagttcta                                                   20


<210> 26094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26094
aagcctgcaa ccagctgccc                                                   20


<210> 26095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26095
tggacttgaa agcctgcaac                                                   20


<210> 26096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26096
tcggccccag ctggacttga                                                   20


<210> 26097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26097
agagaagcct cggccccagc                                                   20


<210> 26098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26098
aagaagagaa gcctcggccc                                                   20


<210> 26099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 26099
aggaccaaga agagaagcct                                                   20


<210> 26100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26100
agcagaagga ccaagaagag                                                   20


<210> 26101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26101
gggagcagaa ggaccaagaa                                                   20


<210> 26102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26102
tagggagcag aaggaccaag                                                   20


<210> 26103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26103
gcatagggag cagaaggacc                                                   20


<210> 26104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26104
agagaagcat agggagcaga                                                   20


<210> 26105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26105
gagagaagca tagggagcag                                                   20


<210> 26106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26106
ccagagagaa gcatagggag                                                   20


<210> 26107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26107
aagccagaga gaagcatagg                                                   20


<210> 26108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26108
gaaagccaga gagaagcata                                                   20


<210> 26109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26109
agaaagccag agagaagcat                                                   20


<210> 26110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26110
aagaaagcca gagagaagca                                                   20


<210> 26111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26111
gaacaaagaa agccagagag                                                   20


<210> 26112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26112
agggaacaaa gaaagccaga                                                   20


<210> 26113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26113
gcagggaaca aagaaagcca                                                   20


<210> 26114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26114
aagcagggaa caaagaaagc                                                   20


<210> 26115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26115
tgccaagcag ggaacaaaga                                                   20


<210> 26116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26116
ttgctgccaa gcagggaaca                                                   20


<210> 26117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26117
aagcaaattg ctgccaagca                                                   20


<210> 26118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26118
gaagcaaatt gctgccaagc                                                   20


<210> 26119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26119
agaagcaaat tgctgccaag                                                   20


<210> 26120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26120
tagagaagca aattgctgcc                                                   20


<210> 26121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26121
agtcactggt ggagatagag                                                   20


<210> 26122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26122
cggagtcact ggtggagata                                                   20


<210> 26123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26123
tccggagtca ctggtggaga                                                   20


<210> 26124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26124
ttactccgga gtcactggtg                                                   20


<210> 26125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26125
ctttactccg gagtcactgg                                                   20


<210> 26126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26126
tcgctttact ccggagtcac                                                   20


<210> 26127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26127
acttccgtcg ctttactccg                                                   20


<210> 26128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 26128
caacttccgt cgctttactc                                                   20


<210> 26129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26129
gagaagatgg aattccccat                                                   20


<210> 26130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26130
cctgaagaag aatgagaaga                                                   20


<210> 26131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26131
acttcctgaa gaagaatgag                                                   20


<210> 26132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26132
aatacttcct gaagaagaat                                                   20


<210> 26133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26133
agtataaata cttcctgaag                                                   20


<210> 26134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26134
aagagtataa atacttcctg                                                   20


<210> 26135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26135
ggttatgtcc actcttataa                                                   20


<210> 26136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26136
gtggttatgt ccactcttat                                                   20


<210> 26137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26137
ggcaagctgt cacctctctg                                                   20


<210> 26138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26138
gagggacagg gccagtgggc                                                   20


<210> 26139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26139
atgagaggga cagggccagt                                                   20


<210> 26140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26140
gatgagaggg acagggccag                                                   20


<210> 26141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26141
acagatgaga gggacagggc                                                   20


<210> 26142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26142
tgggacagat gagagggaca                                                   20


<210> 26143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26143
atgggacaga tgagagggac                                                   20


<210> 26144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26144
gatgggacag atgagaggga                                                   20


<210> 26145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26145
tcaagatggg acagatgaga                                                   20


<210> 26146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26146
atcaagatgg gacagatgag                                                   20


<210> 26147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26147
aatcaagatg ggacagatga                                                   20


<210> 26148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26148
acaatcaaga tgggacagat                                                   20


<210> 26149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26149
ttctgacaat caagatggga                                                   20


<210> 26150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26150
gctgttctga caatcaagat                                                   20


<210> 26151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26151
ggctgttctg acaatcaaga                                                   20


<210> 26152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26152
gaagggctgt tctgacaatc                                                   20


<210> 26153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26153
cagatatgag ggtgggagaa                                                   20


<210> 26154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26154
ccagatatga gggtgggaga                                                   20


<210> 26155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26155
gccagatatg agggtgggag                                                   20


<210> 26156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26156
ggggccagat atgagggtgg                                                   20


<210> 26157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26157
gaggggccag atatgagggt                                                   20


<210> 26158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26158
ggaggggcca gatatgaggg                                                   20


<210> 26159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26159
cagggagggg ccagatatga                                                   20


<210> 26160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26160
tcagggaggg gccagatatg                                                   20


<210> 26161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26161
ttcagggagg ggccagatat                                                   20


<210> 26162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26162
gtgtgagttc agggaggggc                                                   20


<210> 26163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26163
ccaagtgtga gttcagggag                                                   20


<210> 26164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26164
gccaagtgtg agttcaggga                                                   20


<210> 26165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26165
agccaagtgt gagttcaggg                                                   20


<210> 26166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26166
gagccaagtg tgagttcagg                                                   20


<210> 26167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26167
aggagccaag tgtgagttca                                                   20


<210> 26168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26168
gaggagccaa gtgtgagttc                                                   20


<210> 26169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26169
ggaggagcca agtgtgagtt                                                   20


<210> 26170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26170
tcctgggagg agccaagtgt                                                   20


<210> 26171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26171
atgggttcct gggaggagcc                                                   20


<210> 26172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26172
ggggaatggg ttcctgggag                                                   20


<210> 26173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26173
caggggaatg ggttcctggg                                                   20


<210> 26174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26174
gcaggggaat gggttcctgg                                                   20


<210> 26175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26175
ttgcagggga atgggttcct                                                   20


<210> 26176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26176
cttgcagggg aatgggttcc                                                   20


<210> 26177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26177
tgaatgcctt gcaggggaat                                                   20


<210> 26178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26178
ctgaatgcct tgcaggggaa                                                   20


<210> 26179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26179
ctcccctgaa tgccttgcag                                                   20


<210> 26180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26180
cctcccctga atgccttgca                                                   20


<210> 26181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26181
gcctcccctg aatgccttgc                                                   20


<210> 26182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26182
agcctcccct gaatgccttg                                                   20


<210> 26183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26183
ctggaggagg gttgaataaa                                                   20


<210> 26184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26184
accctgaggc acctggagga                                                   20


<210> 26185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26185
aaccctgagg cacctggagg                                                   20


<210> 26186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26186
taaccctgag gcacctggag                                                   20


<210> 26187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26187
cataaccctg aggcacctgg                                                   20


<210> 26188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26188
acataaccct gaggcacctg                                                   20


<210> 26189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26189
agacataacc ctgaggcacc                                                   20


<210> 26190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26190
ggagcaaaga cataaccctg                                                   20


<210> 26191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26191
gggagcaaag acataaccct                                                   20


<210> 26192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26192
atagaagcac atggggagca                                                   20


<210> 26193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26193
atgacataga agcacatggg                                                   20


<210> 26194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26194
caatgacata gaagcacatg                                                   20


<210> 26195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26195
gcaatgacat agaagcacat                                                   20


<210> 26196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26196
agcaatgaca tagaagcaca                                                   20


<210> 26197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26197
gtgaagaagc aatgacatag                                                   20


<210> 26198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26198
gtggtgaaga agcaatgaca                                                   20


<210> 26199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26199
gatggtacaa agtggtgaag                                                   20


<210> 26200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26200
taggatggta caaagtggtg                                                   20


<210> 26201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26201
ggtggtagga tggtacaaag                                                   20


<210> 26202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26202
ggtggtggta ggatggtaca                                                   20


<210> 26203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26203
atctggtggt ggtggtagga                                                   20


<210> 26204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26204
ctaaatctgg tggtggtggt                                                   20


<210> 26205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26205
gctaaatctg gtggtggtgg                                                   20


<210> 26206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26206
atggctaaat ctggtggtgg                                                   20


<210> 26207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26207
agcatggcta aatctggtgg                                                   20


<210> 26208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26208
ggcagcatgg ctaaatctgg                                                   20


<210> 26209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26209
gagggcagca tggctaaatc                                                   20


<210> 26210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26210
aatgaggaga gagggcagca                                                   20


<210> 26211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26211
ctggaaatga ggagagaggg                                                   20


<210> 26212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26212
gtcctggaaa tgaggagaga                                                   20


<210> 26213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26213
ggtcctggaa atgaggagag                                                   20


<210> 26214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26214
tggtcctgga aatgaggaga                                                   20


<210> 26215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26215
agtggtcctg gaaatgagga                                                   20


<210> 26216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26216
tcagtggtcc tggaaatgag                                                   20


<210> 26217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26217
actcagtggt cctggaaatg                                                   20


<210> 26218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26218
aactcagtgg tcctggaaat                                                   20


<210> 26219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26219
tgcctggaac tcagtggtcc                                                   20


<210> 26220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26220
ggagagtgcc tggaactcag                                                   20


<210> 26221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26221
atgggagagt gcctggaact                                                   20


<210> 26222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26222
gatgaatatg ggagagtgcc                                                   20


<210> 26223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26223
agtctttgat gaatatggga                                                   20


<210> 26224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26224
aaagtctttg atgaatatgg                                                   20


<210> 26225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26225
ccaaagtctt tgatgaatat                                                   20


<210> 26226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26226
accaaagtct ttgatgaata                                                   20


<210> 26227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26227
ataaagtaga ctataaacca                                                   20


<210> 26228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26228
gcatgagact taagataaag                                                   20


<210> 26229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26229
gtagcatgag acttaagata                                                   20


<210> 26230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26230
aagaaagtag catgagactt                                                   20


<210> 26231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26231
ttgtgataag aaagtagcat                                                   20


<210> 26232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26232
aaaagattgt gataagaaag                                                   20


<210> 26233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26233
aataaaagat tgtgataaga                                                   20


<210> 26234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26234
aataaataaa agattgtgat                                                   20


<210> 26235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26235
ttgacaatgt caataaataa                                                   20


<210> 26236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26236
aaatgaaatt caaacaggtg                                                   20


<210> 26237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26237
ccaaatgaaa ttcaaacagg                                                   20


<210> 26238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26238
ggtccaaatg aaattcaaac                                                   20


<210> 26239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26239
aggtccaaat gaaattcaaa                                                   20


<210> 26240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26240
ggagttctcc agtaacttgg                                                   20


<210> 26241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26241
tggagttctc cagtaacttg                                                   20


<210> 26242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26242
tctggagttc tccagtaact                                                   20


<210> 26243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26243
tccaataatc tggagttctc                                                   20


<210> 26244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26244
tgaaattctc caataatctg                                                   20


<210> 26245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26245
aatgaaattc tccaataatc                                                   20


<210> 26246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26246
ggaggtccca gagaaattgg                                                   20


<210> 26247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26247
tggaggtccc agagaaattg                                                   20


<210> 26248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26248
cctggaggtc ccagagaaat                                                   20


<210> 26249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26249
gactgaacct ggaggtccca                                                   20


<210> 26250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26250
cagactgaac ctggaggtcc                                                   20


<210> 26251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26251
cagccacaga ctgaacctgg                                                   20


<210> 26252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26252
tcagccacag actgaacctg                                                   20


<210> 26253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26253
gttcagccac agactgaacc                                                   20


<210> 26254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26254
tggggaaaag tgttcagcca                                                   20


<210> 26255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26255
tggttatggg gaaaagtgtt                                                   20


<210> 26256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26256
tctaatctgg ttatggggaa                                                   20


<210> 26257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26257
acaggtctaa tctggttatg                                                   20


<210> 26258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26258
cacaggtcta atctggttat                                                   20


<210> 26259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26259
ccacaggtct aatctggtta                                                   20


<210> 26260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26260
tgtggaccac aggtctaatc                                                   20


<210> 26261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26261
gtggcaaaat tgtggaccac                                                   20


<210> 26262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26262
agtggcaaaa ttgtggacca                                                   20


<210> 26263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26263
gtgagggagt ggcaaaattg                                                   20


<210> 26264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26264
ttaggataag ggtgagggag                                                   20


<210> 26265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26265
gatttaggat aagggtgagg                                                   20


<210> 26266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26266
gggatttagg ataagggtga                                                   20


<210> 26267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26267
tgggatttag gataagggtg                                                   20


<210> 26268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26268
ttgggattta ggataagggt                                                   20


<210> 26269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26269
agccttggga tttaggataa                                                   20


<210> 26270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26270
tagccttggg atttaggata                                                   20


<210> 26271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26271
ttagccttgg gatttaggat                                                   20


<210> 26272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26272
ttgacttagc cttgggattt                                                   20


<210> 26273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26273
attgacttag ccttgggatt                                                   20


<210> 26274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26274
ttctagattg acttagcctt                                                   20


<210> 26275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26275
gttctagatt gacttagcct                                                   20


<210> 26276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26276
ggaactgttc tagattgact                                                   20


<210> 26277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26277
gcagttcagg ggaactgttc                                                   20


<210> 26278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26278
ataacccctc agcagttcag                                                   20


<210> 26279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26279
cataacccct cagcagttca                                                   20


<210> 26280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26280
ccataacccc tcagcagttc                                                   20


<210> 26281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26281
cccataaccc ctcagcagtt                                                   20


<210> 26282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26282
ggttccccat aacccctcag                                                   20


<210> 26283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26283
tgaggttccc cataacccct                                                   20


<210> 26284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26284
atgattccca ggcaatactg                                                   20


<210> 26285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26285
tatgattccc aggcaatact                                                   20


<210> 26286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26286
agggatacca tatgattccc                                                   20


<210> 26287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26287
tagggatacc atatgattcc                                                   20


<210> 26288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26288
ctagaagaaa ctgctgacta                                                   20


<210> 26289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26289
actagaagaa actgctgact                                                   20


<210> 26290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26290
gactagaaga aactgctgac                                                   20


<210> 26291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26291
tatttgaaac ctcagactag                                                   20


<210> 26292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26292
gtgtatttga aacctcagac                                                   20


<210> 26293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26293
aaagagtgta tttgaaacct                                                   20


<210> 26294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26294
gacagggaat agtgagaaaa                                                   20


<210> 26295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26295
aagacaggga atagtgagaa                                                   20


<210> 26296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26296
aagggaagac agggaatagt                                                   20


<210> 26297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26297
ctgcaaggga agacagggaa                                                   20


<210> 26298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26298
gcttactgca agggaagaca                                                   20


<210> 26299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26299
ggcttactgc aagggaagac                                                   20


<210> 26300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26300
tggcttactg caagggaaga                                                   20


<210> 26301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26301
tcattggctt actgcaaggg                                                   20


<210> 26302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26302
tggtcattgg cttactgcaa                                                   20


<210> 26303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26303
atggtcattg gcttactgca                                                   20


<210> 26304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26304
tatggtcatt ggcttactgc                                                   20


<210> 26305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26305
gaactaggaa atatggtcat                                                   20


<210> 26306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26306
tctccatgaa ctaggaaata                                                   20


<210> 26307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26307
tctgtttttc tccatgaact                                                   20


<210> 26308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26308
ttctgttttt ctccatgaac                                                   20


<210> 26309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26309
ttgatggtat gaagttggca                                                   20


<210> 26310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26310
gtttgatggt atgaagttgg                                                   20


<210> 26311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26311
gaggtttgat ggtatgaagt                                                   20


<210> 26312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26312
gttggaggtt tgatggtatg                                                   20


<210> 26313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26313
caggtgagtt ggaggtttga                                                   20


<210> 26314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26314
tgcagacaca ggtgagttgg                                                   20


<210> 26315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26315
ctgcagacac aggtgagttg                                                   20


<210> 26316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26316
ggctgcagac acaggtgagt                                                   20


<210> 26317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26317
agaaggctgc agacacaggt                                                   20


<210> 26318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26318
ggaaagaagg ctgcagacac                                                   20


<210> 26319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26319
aggaaagaag gctgcagaca                                                   20


<210> 26320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26320
ggaaggagga aagaaggctg                                                   20


<210> 26321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26321
gagaagggaa ggaggaaaga                                                   20


<210> 26322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26322
agagaaggga aggaggaaag                                                   20


<210> 26323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26323
gtaagagaag ggaaggagga                                                   20


<210> 26324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26324
tgttgtaaga gaagggaagg                                                   20


<210> 26325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26325
atgttgtaag agaagggaag                                                   20


<210> 26326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26326
tcatgttgta agagaaggga                                                   20


<210> 26327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26327
ctcatgttgt aagagaaggg                                                   20


<210> 26328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26328
cctctcatgt tgtaagagaa                                                   20


<210> 26329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26329
acctctcatg ttgtaagaga                                                   20


<210> 26330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26330
tacctctcat gttgtaagag                                                   20


<210> 26331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26331
agatacctct catgttgtaa                                                   20


<210> 26332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26332
gaagatacct ctcatgttgt                                                   20


<210> 26333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26333
aatggtcctt agaatgtagg                                                   20


<210> 26334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26334
aggaatggtc cttagaatgt                                                   20


<210> 26335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26335
aaggaatggt ccttagaatg                                                   20


<210> 26336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26336
agagggaaag gaatggtcct                                                   20


<210> 26337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26337
cctaagcaga gggaaaggaa                                                   20


<210> 26338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26338
aagatcctaa gcagagggaa                                                   20


<210> 26339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26339
taagatccta agcagaggga                                                   20


<210> 26340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26340
gagataagat cctaagcaga                                                   20


<210> 26341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26341
tgagataaga tcctaagcag                                                   20


<210> 26342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26342
atgagataag atcctaagca                                                   20


<210> 26343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26343
atatgagata agatcctaag                                                   20


<210> 26344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26344
tagatatgag ataagatcct                                                   20


<210> 26345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26345
aaatgaggta gatatgagat                                                   20


<210> 26346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26346
gaaaaaaatg aggtagatat                                                   20


<210> 26347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26347
ggagagagaa aaaaatgagg                                                   20


<210> 26348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26348
caaggagaga gaaaaaaatg                                                   20


<210> 26349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26349
acaaggagag agaaaaaaat                                                   20


<210> 26350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26350
agagctggca gacaaggaga                                                   20


<210> 26351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26351
aaagagctgg cagacaagga                                                   20


<210> 26352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26352
ggaaagagct ggcagacaag                                                   20


<210> 26353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26353
taggaaagag ctggcagaca                                                   20


<210> 26354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26354
ataggaaaga gctggcagac                                                   20


<210> 26355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26355
tgctgatagg aaagagctgg                                                   20


<210> 26356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26356
aaatgctgat aggaaagagc                                                   20


<210> 26357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26357
ctttaaatgc tgataggaaa                                                   20


<210> 26358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26358
atctttaaat gctgatagga                                                   20


<210> 26359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26359
aagcatcttt aaatgctgat                                                   20


<210> 26360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26360
taagcatctt taaatgctga                                                   20


<210> 26361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26361
tttaaagttg gaggaaagtt                                                   20


<210> 26362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26362
aagtttttaa agttggagga                                                   20


<210> 26363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26363
gggaaagttt ttaaagttgg                                                   20


<210> 26364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26364
agggaaagtt tttaaagttg                                                   20


<210> 26365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26365
caagggaaag tttttaaagt                                                   20


<210> 26366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26366
gcatcaaggg aaagttttta                                                   20


<210> 26367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26367
atgggctctg catcaaggga                                                   20


<210> 26368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26368
ctggatgggc tctgcatcaa                                                   20


<210> 26369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26369
cctggatggg ctctgcatca                                                   20


<210> 26370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26370
acctggatgg gctctgcatc                                                   20


<210> 26371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26371
agaggaggga agacctggat                                                   20


<210> 26372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26372
gagaggaggg aagacctgga                                                   20


<210> 26373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26373
aggagagagg agggaagacc                                                   20


<210> 26374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26374
gagaacagga gagaggaggg                                                   20


<210> 26375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26375
atagagaaca ggagagagga                                                   20


<210> 26376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26376
aatagagaac aggagagagg                                                   20


<210> 26377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26377
caatagagaa caggagagag                                                   20


<210> 26378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26378
gccaatagag aacaggagag                                                   20


<210> 26379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26379
agccaataga gaacaggaga                                                   20


<210> 26380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26380
aaagccaata gagaacagga                                                   20


<210> 26381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26381
taaaagccaa tagagaacag                                                   20


<210> 26382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26382
attaaaagcc aatagagaac                                                   20


<210> 26383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26383
tattaaaagc caatagagaa                                                   20


<210> 26384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26384
tcctttatta aaagccaata                                                   20


<210> 26385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26385
agtcctttat taaaagccaa                                                   20


<210> 26386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26386
agaagtaagt cctttattaa                                                   20


<210> 26387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26387
tggaaacagt gagtagaagt                                                   20


<210> 26388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26388
tgactggaaa cagtgagtag                                                   20


<210> 26389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26389
aagtgactgg aaacagtgag                                                   20


<210> 26390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26390
gaaaagtgac tggaaacagt                                                   20


<210> 26391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26391
gactgaaaag tgactggaaa                                                   20


<210> 26392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26392
ttcaaagact gaaaagtgac                                                   20


<210> 26393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26393
tccaagcttc aaagactgaa                                                   20


<210> 26394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26394
agggcaaaat ccaagcttca                                                   20


<210> 26395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26395
gagataggag ggcaaaatcc                                                   20


<210> 26396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26396
agcattttag tgagatagga                                                   20


<210> 26397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26397
aagcatttta gtgagatagg                                                   20


<210> 26398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26398
gaagcatttt agtgagatag                                                   20


<210> 26399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26399
aggaagcatt ttagtgagat                                                   20


<210> 26400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26400
aaggaagcat tttagtgaga                                                   20


<210> 26401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26401
ctgcaaggaa gcattttagt                                                   20


<210> 26402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26402
atccctgcaa ggaagcattt                                                   20


<210> 26403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26403
tctcttgtat ccctgcaagg                                                   20


<210> 26404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26404
caatctcttg tatccctgca                                                   20


<210> 26405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26405
gcaatctctt gtatccctgc                                                   20


<210> 26406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26406
gccccctgac tttagccaca                                                   20


<210> 26407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26407
ggccccctga ctttagccac                                                   20


<210> 26408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26408
tgagaagggc cccctgactt                                                   20


<210> 26409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26409
aaaaagacaa gaactgagaa                                                   20


<210> 26410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26410
aaaaaagaca agaactgaga                                                   20


<210> 26411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26411
caaaaaagac aagaactgag                                                   20


<210> 26412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26412
aaacaaaaaa gacaagaact                                                   20


<210> 26413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26413
aagaaaaaaa caaaaaagac                                                   20


<210> 26414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26414
agaaaaagaa aaaaacaaaa                                                   20


<210> 26415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26415
aaaaaaaaaa gaaaaagaaa                                                   20


<210> 26416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26416
ctcaaaaaaa aaaaaagaaa                                                   20


<210> 26417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26417
ccctgtctca aaaaaaaaaa                                                   20


<210> 26418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26418
ctgcactcta gtccgggtga                                                   20


<210> 26419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26419
gcaccactgc actctagtcc                                                   20


<210> 26420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 26420
tgcaccactg cactctagtc                                                   20


<210> 26421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26421
gagattgcac cactgcactc                                                   20


<210> 26422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26422
gacagaggtt gcagtgagca                                                   20


<210> 26423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26423
gagacagagg ttgcagtgag                                                   20


<210> 26424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26424
caggagacag aggttgcagt                                                   20


<210> 26425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26425
agcccaggag acagaggttg                                                   20


<210> 26426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26426
tgcttgagcc caggagacag                                                   20


<210> 26427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26427
ttgcttgagc ccaggagaca                                                   20


<210> 26428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26428
aattgcttga gcccaggaga                                                   20


<210> 26429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26429
ggagaattgc ttgagcccag                                                   20


<210> 26430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26430
tgggagaatt gcttgagccc                                                   20


<210> 26431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26431
gtgggagaat tgcttgagcc                                                   20


<210> 26432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26432
ctgaggtggg agaattgctt                                                   20


<210> 26433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26433
tattcgggag gctgaggtgg                                                   20


<210> 26434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26434
gctattcggg aggctgaggt                                                   20


<210> 26435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26435
agctattcgg gaggctgagg                                                   20


<210> 26436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26436
cccagctatt cgggaggctg                                                   20


<210> 26437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26437
gcccagctat tcgggaggct                                                   20


<210> 26438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26438
ctatagccca gctattcggg                                                   20


<210> 26439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26439
cctatagccc agctattcgg                                                   20


<210> 26440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26440
tgcctatagc ccagctattc                                                   20


<210> 26441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 26441
gtgcctatag cccagctatt                                                   20


<210> 26442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26442
ggtgacatgt gcctatagcc                                                   20


<210> 26443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26443
agtgtggtga catgtgccta                                                   20


<210> 26444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26444
ttttcaaaac tagccgagtg                                                   20


<210> 26445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26445
aaattttttc aaaactagcc                                                   20


<210> 26446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26446
caaaaaaatt ttttcaaaac                                                   20


<210> 26447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26447
gatgggcctg gacaatatag                                                   20


<210> 26448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26448
tgagatgggc ctggacaata                                                   20


<210> 26449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26449
gataagaact gagatgggcc                                                   20


<210> 26450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26450
atcaagataa gaactgagat                                                   20


<210> 26451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26451
catcaagata agaactgaga                                                   20


<210> 26452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26452
ggaccatcaa gataagaact                                                   20


<210> 26453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26453
gccaatagga ccatcaagat                                                   20


<210> 26454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26454
aaacagccaa taggaccatc                                                   20


<210> 26455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26455
aaattgtcaa aacagccaat                                                   20


<210> 26456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26456
gaaattgtca aaacagccaa                                                   20


<210> 26457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26457
taaggaggaa attgtcaaaa                                                   20


<210> 26458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26458
aaatatacag tattttaagg                                                   20


<210> 26459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26459
aaaatataca gtattttaag                                                   20


<210> 26460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26460
ccaaaatata cagtatttta                                                   20


<210> 26461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26461
gccaaaatat acagtatttt                                                   20


<210> 26462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26462
gtcatggtag ccaaaatata                                                   20


<210> 26463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26463
aaaccaagag agtgtcatgg                                                   20


<210> 26464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26464
ggaaaaccaa gagagtgtca                                                   20


<210> 26465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26465
gaaagttagg aaaaccaaga                                                   20


<210> 26466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26466
gagaaagtta ggaaaaccaa                                                   20


<210> 26467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26467
gagagaaagt taggaaaacc                                                   20


<210> 26468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26468
gaaggagaag agagaaagtt                                                   20


<210> 26469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26469
agaaggagaa gagagaaagt                                                   20


<210> 26470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26470
actgagaagg agaagagaga                                                   20


<210> 26471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26471
agagactgag aaggagaaga                                                   20


<210> 26472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26472
ggagagactg agaaggagaa                                                   20


<210> 26473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26473
aaggagagac tgagaaggag                                                   20


<210> 26474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26474
agaaaggaga gactgagaag                                                   20


<210> 26475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26475
tgagaaagga gagactgaga                                                   20


<210> 26476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26476
ctgagaaagg agagactgag                                                   20


<210> 26477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26477
aagctgagaa aggagagact                                                   20


<210> 26478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26478
tgggaaaagc tgagaaagga                                                   20


<210> 26479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26479
tatgggaaaa gctgagaaag                                                   20


<210> 26480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26480
tgtatgggaa aagctgagaa                                                   20


<210> 26481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26481
atgtatggga aaagctgaga                                                   20


<210> 26482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26482
aatcatgtat gggaaaagct                                                   20


<210> 26483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26483
ttcacaatca tgtatgggaa                                                   20


<210> 26484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26484
cattattcac aatcatgtat                                                   20


<210> 26485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26485
ccattattca caatcatgta                                                   20


<210> 26486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26486
tattctgaaa acaaaagata                                                   20


<210> 26487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26487
attattctga aaacaaaaga                                                   20


<210> 26488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26488
tgttattatt ctgaaaacaa                                                   20


<210> 26489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26489
agtaaatgct agcgctgttg                                                   20


<210> 26490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26490
agtggaatct cagtaaatgc                                                   20


<210> 26491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26491
tctgaaatac agtggaatct                                                   20


<210> 26492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26492
atccagagtc tgaaatacag                                                   20


<210> 26493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26493
ttaatccaga gtctgaaata                                                   20


<210> 26494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26494
catgaaaatt gcttaatcca                                                   20


<210> 26495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26495
tgcatgaaaa ttgcttaatc                                                   20


<210> 26496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26496
atacttcaca ggtacagtga                                                   20


<210> 26497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26497
gagataatac ttcacaggta                                                   20


<210> 26498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26498
tattagagat aatacttcac                                                   20


<210> 26499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26499
atattagaga taatacttca                                                   20


<210> 26500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26500
ggtatcttat ttatatatta                                                   20


<210> 26501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26501
ctggtatctt atttatatat                                                   20


<210> 26502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26502
aaattttaac tttgctgctc                                                   20


<210> 26503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26503
actcattagt aatgtgatct                                                   20


<210> 26504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26504
agtaccgttc tgccactcat                                                   20


<210> 26505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26505
tggcaaacat acctgagttt                                                   20


<210> 26506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26506
agattgtggc aaacatacct                                                   20


<210> 26507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26507
gagatgtttc caagagattg                                                   20


<210> 26508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26508
gaatgatgag atgtttccaa                                                   20


<210> 26509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26509
gggaatgatg agatgtttcc                                                   20


<210> 26510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26510
agtgaagata tgggaatgat                                                   20


<210> 26511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26511
taaatgagaa gtgaagatat                                                   20


<210> 26512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26512
ataaatgaga agtgaagata                                                   20


<210> 26513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26513
ctgcatataa atgagaagtg                                                   20


<210> 26514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26514
gtcatctgca tataaatgag                                                   20


<210> 26515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26515
tcagtcatct gcatataaat                                                   20


<210> 26516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26516
gagagctaca gataaagact                                                   20


<210> 26517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26517
acttctgaga gctacagata                                                   20


<210> 26518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26518
ccatggactt ctgagagcta                                                   20


<210> 26519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26519
tgagccccat ggacttctga                                                   20


<210> 26520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26520
tctgagcccc atggacttct                                                   20


<210> 26521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26521
aaatgaagat ctgagcccca                                                   20


<210> 26522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26522
gagagatcaa atgaagatct                                                   20


<210> 26523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26523
tgaagtggag agatcaaatg                                                   20


<210> 26524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26524
tcatgagaca ctgaagtgga                                                   20


<210> 26525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26525
gctcatgaga cactgaagtg                                                   20


<210> 26526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26526
gtgctcatga gacactgaag                                                   20


<210> 26527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26527
gaggtgctca tgagacactg                                                   20


<210> 26528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26528
gctgagcttg aggtgctcat                                                   20


<210> 26529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26529
tttggggcat gctgagcttg                                                   20


<210> 26530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26530
gtttggggca tgctgagctt                                                   20


<210> 26531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26531
agtttagttt ggggcatgct                                                   20


<210> 26532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26532
ataattatga gtttagtttg                                                   20


<210> 26533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26533
gataattatg agtttagttt                                                   20


<210> 26534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26534
agataattat gagtttagtt                                                   20


<210> 26535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26535
tgaggagata attatgagtt                                                   20


<210> 26536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26536
agaagtgagg agataattat                                                   20


<210> 26537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26537
aggtattaga aagaagtgag                                                   20


<210> 26538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26538
gcaggtatta gaaagaagtg                                                   20


<210> 26539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26539
ggcaggtatt agaaagaagt                                                   20


<210> 26540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26540
gagaggcagg tattagaaag                                                   20


<210> 26541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26541
gaagagaggc aggtattaga                                                   20


<210> 26542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26542
catagaagag aggcaggtat                                                   20


<210> 26543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26543
aaaagacata gaagagaggc                                                   20


<210> 26544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26544
aaaaagacat agaagagagg                                                   20


<210> 26545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26545
agtaaaaaga catagaagag                                                   20


<210> 26546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26546
cagtaaaaag acatagaaga                                                   20


<210> 26547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26547
ggcagtaaaa agacatagaa                                                   20


<210> 26548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26548
atggcagtaa aaagacatag                                                   20


<210> 26549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26549
ctaatggcag taaaaagaca                                                   20


<210> 26550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26550
ttggggctaa tggcagtaaa                                                   20


<210> 26551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26551
aggctatttg gggctaatgg                                                   20


<210> 26552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26552
aacaggctat ttggggctaa                                                   20


<210> 26553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26553
acacagaaac aggctatttg                                                   20


<210> 26554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26554
gacacagaaa caggctattt                                                   20


<210> 26555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26555
agacacagaa acaggctatt                                                   20


<210> 26556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26556
ttgtggacag acacagaaac                                                   20


<210> 26557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26557
gttgtggaca gacacagaaa                                                   20


<210> 26558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26558
acccaggttg tggacagaca                                                   20


<210> 26559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26559
tatggtaccc aggttgtgga                                                   20


<210> 26560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26560
taattatggt acccaggttg                                                   20


<210> 26561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26561
agagcataat tatggtaccc                                                   20


<210> 26562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26562
aagagcataa ttatggtacc                                                   20


<210> 26563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26563
aaatagaaag agcataatta                                                   20


<210> 26564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26564
tatgtggaat gaaatagaaa                                                   20


<210> 26565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26565
tgtatgtgga atgaaataga                                                   20


<210> 26566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26566
tgattgtatg tggaatgaaa                                                   20


<210> 26567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26567
actagatgtt tgattgtatg                                                   20


<210> 26568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26568
ggaggcagaa gcaacagcac                                                   20


<210> 26569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26569
tattaaggag gcagaagcaa                                                   20


<210> 26570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26570
agaagatatt aaggaggcag                                                   20


<210> 26571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26571
aagagaagat attaaggagg                                                   20


<210> 26572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26572
atgaagagaa gatattaagg                                                   20


<210> 26573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26573
tatgaagaga agatattaag                                                   20


<210> 26574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26574
gatatgaaga gaagatatta                                                   20


<210> 26575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26575
agatatgaag agaagatatt                                                   20


<210> 26576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26576
ggttagagag atatgaagag                                                   20


<210> 26577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26577
agaggttaga gagatatgaa                                                   20


<210> 26578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26578
ggagaggtta gagagatatg                                                   20


<210> 26579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26579
agtatgatgg agaggttaga                                                   20


<210> 26580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26580
gcagtatgat ggagaggtta                                                   20


<210> 26581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26581
cagcagtatg atggagaggt                                                   20


<210> 26582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26582
ggaccagcag tatgatggag                                                   20


<210> 26583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26583
tggaccagca gtatgatgga                                                   20


<210> 26584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26584
attggaccag cagtatgatg                                                   20


<210> 26585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26585
tgattggacc agcagtatga                                                   20


<210> 26586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26586
gatgacagtg attggaccag                                                   20


<210> 26587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26587
tgagatgaca gtgattggac                                                   20


<210> 26588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26588
gccagtgaga tgacagtgat                                                   20


<210> 26589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26589
atacgaggcc agtgagatga                                                   20


<210> 26590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26590
atgacacata cgaggccagt                                                   20


<210> 26591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26591
caaaatgaca catacgaggc                                                   20


<210> 26592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26592
gaatcaaaat gacacatacg                                                   20


<210> 26593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26593
ggaatcaaaa tgacacatac                                                   20


<210> 26594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26594
taggttagaa aggactaaag                                                   20


<210> 26595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26595
ataggttaga aaggactaaa                                                   20


<210> 26596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26596
aataggttag aaaggactaa                                                   20


<210> 26597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26597
gaataggtta gaaaggacta                                                   20


<210> 26598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26598
tgttggagaa taggttagaa                                                   20


<210> 26599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26599
ctgttggaga ataggttaga                                                   20


<210> 26600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26600
gccactgttg gagaataggt                                                   20


<210> 26601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26601
tttggccact gttggagaat                                                   20


<210> 26602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26602
atttggccac tgttggagaa                                                   20


<210> 26603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26603
atatcatttg gccactgttg                                                   20


<210> 26604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26604
aaatatcatt tggccactgt                                                   20


<210> 26605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26605
ttcattttag aaatatcatt                                                   20


<210> 26606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26606
acataaccag attttcattt                                                   20


<210> 26607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26607
aaataaagat atcacataac                                                   20


<210> 26608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26608
ctttagaatg attttaaata                                                   20


<210> 26609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26609
ttgagtgcta tggagagctt                                                   20


<210> 26610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26610
gttatcttga gtgctatgga                                                   20


<210> 26611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26611
gggttatctt gagtgctatg                                                   20


<210> 26612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26612
ttgggttatc ttgagtgcta                                                   20


<210> 26613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26613
cgcacagttt gggttatctt                                                   20


<210> 26614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26614
gagaggtcag cgcacagttt                                                   20


<210> 26615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26615
ggagaggtca gcgcacagtt                                                   20


<210> 26616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26616
atgctggaga ggtcagcgca                                                   20


<210> 26617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26617
gactaccatg ctggagaggt                                                   20


<210> 26618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26618
tggggactac catgctggag                                                   20


<210> 26619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26619
ctggggacta ccatgctgga                                                   20


<210> 26620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26620
ggctggggac taccatgctg                                                   20


<210> 26621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26621
gtggctgggg actaccatgc                                                   20


<210> 26622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26622
ttataaaagt agtgtggctg                                                   20


<210> 26623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26623
cttataaaag tagtgtggct                                                   20


<210> 26624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26624
acttataaaa gtagtgtggc                                                   20


<210> 26625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26625
ataaacttat aaaagtagtg                                                   20


<210> 26626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26626
caaggataaa cttataaaag                                                   20


<210> 26627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26627
attcaaggat aaacttataa                                                   20


<210> 26628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26628
aaaagaatgg gtcaaattca                                                   20


<210> 26629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26629
aaaaagaatg ggtcaaattc                                                   20


<210> 26630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26630
gccttaacat aaaaaagaat                                                   20


<210> 26631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26631
agccttaaca taaaaaagaa                                                   20


<210> 26632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26632
ggaaaagcct taacataaaa                                                   20


<210> 26633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26633
aaaggaaggg gaatatggaa                                                   20


<210> 26634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26634
taggcaaagg aaggggaata                                                   20


<210> 26635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26635
ataattttag gcaaaggaag                                                   20


<210> 26636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26636
gataatttta ggcaaaggaa                                                   20


<210> 26637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26637
agataatttt aggcaaagga                                                   20


<210> 26638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26638
aagataattt taggcaaagg                                                   20


<210> 26639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26639
ggaaagataa ttttaggcaa                                                   20


<210> 26640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26640
tggaaagata attttaggca                                                   20


<210> 26641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26641
taaagtggaa agataatttt                                                   20


<210> 26642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26642
ataaagtgga aagataattt                                                   20


<210> 26643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26643
gccagacaaa ataaagtgga                                                   20


<210> 26644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26644
attagccaga caaaataaag                                                   20


<210> 26645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26645
aggattagcc agacaaaata                                                   20


<210> 26646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26646
aagaataaga gaggattagc                                                   20


<210> 26647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26647
gtacaagaat aagagaggat                                                   20


<210> 26648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26648
caagagtaca agaataagag                                                   20


<210> 26649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26649
ccaagagtac aagaataaga                                                   20


<210> 26650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26650
agccaagagt acaagaataa                                                   20


<210> 26651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26651
aaagccaaga gtacaagaat                                                   20


<210> 26652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26652
tgtctcaaag ccaagagtac                                                   20


<210> 26653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26653
agaaattgtc tcaaagccaa                                                   20


<210> 26654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26654
gaagaaattg tctcaaagcc                                                   20


<210> 26655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26655
aaatggaaga aattgtctca                                                   20


<210> 26656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26656
ttcatatagg tcagaaatgg                                                   20


<210> 26657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26657
gacttcatat aggtcagaaa                                                   20


<210> 26658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26658
aacatagact tcatataggt                                                   20


<210> 26659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26659
tcctaacata gacttcatat                                                   20


<210> 26660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26660
atcctaacat agacttcata                                                   20


<210> 26661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26661
atgaaacagg aatcctaaca                                                   20


<210> 26662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26662
gagttatggg aacatgaaac                                                   20


<210> 26663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26663
agagttatgg gaacatgaaa                                                   20


<210> 26664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26664
gagaaagtgc agagagttat                                                   20


<210> 26665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26665
agagaaagtg cagagagtta                                                   20


<210> 26666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26666
gtttatagag aaagtgcaga                                                   20


<210> 26667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26667
atgtttatag agaaagtgca                                                   20


<210> 26668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26668
agatgtttat agagaaagtg                                                   20


<210> 26669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26669
aaatcagatg tttatagaga                                                   20


<210> 26670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26670
ttacaaatca gatgtttata                                                   20


<210> 26671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26671
aattacaaat cagatgttta                                                   20


<210> 26672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26672
ggcaaacaga aattacaaat                                                   20


<210> 26673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26673
agaaacaata gaaaggcaaa                                                   20


<210> 26674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26674
atttggtaga aacaatagaa                                                   20


<210> 26675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26675
aatttggtag aaacaataga                                                   20


<210> 26676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26676
ttacaatttg gtagaaacaa                                                   20


<210> 26677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26677
tcactgagct tacaatttgg                                                   20


<210> 26678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26678
ctctcactga gcttacaatt                                                   20


<210> 26679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26679
atgtgagtcc agctctcact                                                   20


<210> 26680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26680
gaacaaaata gatgtgagtc                                                   20


<210> 26681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26681
atgctgaaca aaatagatgt                                                   20


<210> 26682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26682
aaaatcaatg ctgaacaaaa                                                   20


<210> 26683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26683
ccaggcactg tactaggttc                                                   20


<210> 26684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26684
ttagttccag gcactgtact                                                   20


<210> 26685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26685
gttagttcca ggcactgtac                                                   20


<210> 26686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26686
ttctgtatct agttagttcc                                                   20


<210> 26687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26687
attctgtatc tagttagttc                                                   20


<210> 26688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26688
ctatctattc tgtatctagt                                                   20


<210> 26689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26689
acaactatct attctgtatc                                                   20


<210> 26690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26690
tctttagttt ttcagctatt                                                   20


<210> 26691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26691
caaaatgttc tttagttttt                                                   20


<210> 26692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26692
tttctgaaca aaatgttctt                                                   20


<210> 26693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26693
gttccttata ttcctattat                                                   20


<210> 26694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26694
aatagactca ataatctctt                                                   20


<210> 26695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26695
tgtgagcttt aaaatgtcaa                                                   20


<210> 26696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26696
tgcttgactt tggggtgtgt                                                   20


<210> 26697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26697
ccaccatctg cttgactttg                                                   20


<210> 26698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26698
gccaccatct gcttgacttt                                                   20


<210> 26699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26699
tgccaccatc tgcttgactt                                                   20


<210> 26700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26700
atcatagggg tatttgattt                                                   20


<210> 26701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26701
aagcaggatc tccatcatag                                                   20


<210> 26702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26702
caagcaggat ctccatcata                                                   20


<210> 26703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26703
gcaagcagga tctccatcat                                                   20


<210> 26704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26704
agcaagcagg atctccatca                                                   20


<210> 26705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26705
taggtatggt gggagcaagc                                                   20


<210> 26706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26706
ctaggtatgg tgggagcaag                                                   20


<210> 26707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26707
cctctaggta tggtgggagc                                                   20


<210> 26708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26708
aatacctcta ggtatggtgg                                                   20


<210> 26709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26709
gaaatacctc taggtatggt                                                   20


<210> 26710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26710
agaaatacct ctaggtatgg                                                   20


<210> 26711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26711
tcaagaaata cctctaggta                                                   20


<210> 26712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26712
tggattcaag aaatacctct                                                   20


<210> 26713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26713
ttggattcaa gaaatacctc                                                   20


<210> 26714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26714
atcacagagg tattggattc                                                   20


<210> 26715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26715
tgtctatatc acagaggtat                                                   20


<210> 26716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26716
aagcagtgtc tatatcacag                                                   20


<210> 26717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26717
taagcagtgt ctatatcaca                                                   20


<210> 26718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26718
aataagcagt gtctatatca                                                   20


<210> 26719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26719
ctagggctgg tgacaataag                                                   20


<210> 26720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26720
cctctagggc tggtgacaat                                                   20


<210> 26721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26721
accagagctg cctctagggc                                                   20


<210> 26722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26722
gggtaccaga gctgcctcta                                                   20


<210> 26723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26723
tgggtaccag agctgcctct                                                   20


<210> 26724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26724
ttgggtacca gagctgcctc                                                   20


<210> 26725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26725
catatgggta ttgggtacca                                                   20


<210> 26726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26726
tacatatggg tattgggtac                                                   20


<210> 26727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26727
gcctcctaca tatgggtatt                                                   20


<210> 26728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26728
agcctcctac atatgggtat                                                   20


<210> 26729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26729
cagcagagcc tcctacatat                                                   20


<210> 26730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26730
ccagcagagc ctcctacata                                                   20


<210> 26731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26731
aggactggtg acaaccagca                                                   20


<210> 26732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26732
gaaggactgg tgacaaccag                                                   20


<210> 26733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26733
atggaaggac tggtgacaac                                                   20


<210> 26734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26734
acttcaatgc atggaaggac                                                   20


<210> 26735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26735
ccaggacttc aatgcatgga                                                   20


<210> 26736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26736
cccaggactt caatgcatgg                                                   20


<210> 26737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26737
cctcccagga cttcaatgca                                                   20


<210> 26738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26738
gagcagtgag tgctcctccc                                                   20


<210> 26739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26739
agagcagtga gtgctcctcc                                                   20


<210> 26740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26740
aggaatggtg tcagagcagt                                                   20


<210> 26741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26741
gaagaggaat ggtgtcagag                                                   20


<210> 26742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26742
aaggaagagg aatggtgtca                                                   20


<210> 26743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26743
ttaaggaaga ggaatggtgt                                                   20


<210> 26744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26744
aggacattaa ggaagaggaa                                                   20


<210> 26745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26745
aatggaggac attaaggaag                                                   20


<210> 26746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26746
taatggagga cattaaggaa                                                   20


<210> 26747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26747
agtaatggag gacattaagg                                                   20


<210> 26748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26748
gaaagtaatg gaggacatta                                                   20


<210> 26749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26749
agaaagtaat ggaggacatt                                                   20


<210> 26750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26750
ctctcagaag aaagtaatgg                                                   20


<210> 26751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26751
gctctcagaa gaaagtaatg                                                   20


<210> 26752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26752
aagctctcag aagaaagtaa                                                   20


<210> 26753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26753
gagggaaagc tctcagaaga                                                   20


<210> 26754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26754
gggtgaggga aagctctcag                                                   20


<210> 26755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26755
agagggtgag ggaaagctct                                                   20


<210> 26756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26756
gagaggaaga gggtgaggga                                                   20


<210> 26757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26757
ggaggagagg aagagggtga                                                   20


<210> 26758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26758
aggaggagag gaagagggtg                                                   20


<210> 26759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26759
caggaggaga ggaagagggt                                                   20


<210> 26760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26760
taggcaggag gagaggaaga                                                   20


<210> 26761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26761
ataggcagga ggagaggaag                                                   20


<210> 26762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26762
aataggcagg aggagaggaa                                                   20


<210> 26763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26763
caaataggca ggaggagagg                                                   20


<210> 26764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26764
ctacaaatag gcaggaggag                                                   20


<210> 26765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26765
actacaaata ggcaggagga                                                   20


<210> 26766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26766
caactacaaa taggcaggag                                                   20


<210> 26767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26767
atcaactaca aataggcagg                                                   20


<210> 26768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26768
gatcaactac aaataggcag                                                   20


<210> 26769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26769
cagatcaact acaaataggc                                                   20


<210> 26770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26770
acagatcaac tacaaatagg                                                   20


<210> 26771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26771
gaaacagatc aactacaaat                                                   20


<210> 26772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26772
agaaacagat caactacaaa                                                   20


<210> 26773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26773
ttgaaaagtt ccgtaagaaa                                                   20


<210> 26774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26774
ttgactttga aaagttccgt                                                   20


<210> 26775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26775
taatgtaggt tgactttgaa                                                   20


<210> 26776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26776
gatgttcaat tatgtaatgt                                                   20


<210> 26777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26777
agatgttcaa ttatgtaatg                                                   20


<210> 26778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26778
agttagaaga aaatagaaga                                                   20


<210> 26779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26779
tctaagttag aagaaaatag                                                   20


<210> 26780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26780
acttctaagt tagaagaaaa                                                   20


<210> 26781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26781
acatagaact tctaagttag                                                   20


<210> 26782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26782
aacacataga acttctaagt                                                   20


<210> 26783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26783
acacaacaca tagaacttct                                                   20


<210> 26784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26784
gaatttgggc acacaacaca                                                   20


<210> 26785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26785
caccatgtta atcagaattt                                                   20


<210> 26786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26786
acaccatgtt aatcagaatt                                                   20


<210> 26787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26787
cataaataca ccatgttaat                                                   20


<210> 26788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26788
tgaagtcaac agtgtttgaa                                                   20


<210> 26789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26789
attaaagaca ctgaagtcaa                                                   20


<210> 26790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26790
gggaagaatt aaagacactg                                                   20


<210> 26791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26791
ttctcagaag ggaagaatta                                                   20


<210> 26792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26792
atctttgttt ctcagaaggg                                                   20


<210> 26793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26793
ttaatctttg tttctcagaa                                                   20


<210> 26794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26794
cttaatcttt gtttctcaga                                                   20


<210> 26795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26795
acttaatctt tgtttctcag                                                   20


<210> 26796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26796
ttaacttaat ctttgtttct                                                   20


<210> 26797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26797
tcccctagac aaggaagaga                                                   20


<210> 26798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26798
cttctcccct agacaaggaa                                                   20


<210> 26799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26799
ctcttctccc ctagacaagg                                                   20


<210> 26800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26800
tatctcttct cccctagaca                                                   20


<210> 26801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26801
gtatctcttc tcccctagac                                                   20


<210> 26802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26802
tataagtatc tcttctcccc                                                   20


<210> 26803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26803
caaatttggt tccaaactat                                                   20


<210> 26804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26804
tgagtcctgg gattcaaatt                                                   20


<210> 26805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26805
ttactaaaca actgagtcct                                                   20


<210> 26806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26806
gttactaaac aactgagtcc                                                   20


<210> 26807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26807
tgcattgtta ctaaacaact                                                   20


<210> 26808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26808
ttgcattcca gtgtcactga                                                   20


<210> 26809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26809
cattgcattc cagtgtcact                                                   20


<210> 26810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26810
caatcctcaa cattgcattc                                                   20


<210> 26811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26811
caggacctgg aattctggct                                                   20


<210> 26812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26812
agctccagga cctggaattc                                                   20


<210> 26813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26813
caagctccag ctccaggacc                                                   20


<210> 26814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26814
tgacctcaag ctccagctcc                                                   20


<210> 26815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26815
ttgacctcaa gctccagctc                                                   20


<210> 26816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26816
tctgctttga cctcaagctc                                                   20


<210> 26817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26817
gctgagtctg ctttgacctc                                                   20


<210> 26818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26818
atgaagtcag tctcatagct                                                   20


<210> 26819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26819
ttggcatgaa gtcagtctca                                                   20


<210> 26820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26820
atggtcattt ggcatgaagt                                                   20


<210> 26821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26821
aattatggtc atttggcatg                                                   20


<210> 26822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26822
ccagaataat tatggtcatt                                                   20


<210> 26823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26823
atggtagccc agaataatta                                                   20


<210> 26824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26824
tggagggatt tatggtagcc                                                   20


<210> 26825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26825
ttagctggag ggatttatgg                                                   20


<210> 26826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26826
tccttagctg gagggattta                                                   20


<210> 26827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26827
caattttgtc cttagctgga                                                   20


<210> 26828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26828
acaattttgt ccttagctgg                                                   20


<210> 26829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26829
aacaattttg tccttagctg                                                   20


<210> 26830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26830
aaaacaattt tgtccttagc                                                   20


<210> 26831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26831
gttgaaaaca attttgtcct                                                   20


<210> 26832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26832
gaaagtctta aaagaaggac                                                   20


<210> 26833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26833
gatgggaaag tcttaaaaga                                                   20


<210> 26834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26834
tgatgggaaa gtcttaaaag                                                   20


<210> 26835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26835
ttctgatggg aaagtcttaa                                                   20


<210> 26836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26836
agctatcact tctgatggga                                                   20


<210> 26837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26837
ccagagctat cacttctgat                                                   20


<210> 26838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26838
tccagagcta tcacttctga                                                   20


<210> 26839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26839
atcaagggat cccaagtcca                                                   20


<210> 26840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26840
caatcaaggg atcccaagtc                                                   20


<210> 26841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26841
cacttcaatc aagggatccc                                                   20


<210> 26842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26842
tagagaacca cttcaatcaa                                                   20


<210> 26843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26843
atagagaacc acttcaatca                                                   20


<210> 26844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26844
tatagagaac cacttcaatc                                                   20


<210> 26845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26845
gggtaataga tgggaatata                                                   20


<210> 26846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26846
ctgggtaata gatgggaata                                                   20


<210> 26847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26847
aaagacactg ggtaatagat                                                   20


<210> 26848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26848
taaagacact gggtaataga                                                   20


<210> 26849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26849
catgtaaaga cactgggtaa                                                   20


<210> 26850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26850
gaatgtcatg taaagacact                                                   20


<210> 26851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26851
agaatgtcat gtaaagacac                                                   20


<210> 26852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26852
ttttctcaga atgtcatgta                                                   20


<210> 26853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26853
ttgcacccca atagttttct                                                   20


<210> 26854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26854
ataaactact tgcaccccaa                                                   20


<210> 26855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26855
acattcctag aaatagctct                                                   20


<210> 26856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26856
ttctatgaca ttcctagaaa                                                   20


<210> 26857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26857
cctctcttct atgacattcc                                                   20


<210> 26858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26858
agtttgccca taagagtaaa                                                   20


<210> 26859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26859
tgagcccagt ttgcccataa                                                   20


<210> 26860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26860
tctgagccca gtttgcccat                                                   20


<210> 26861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26861
cagtgaaaca attctgagcc                                                   20


<210> 26862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26862
cccctcagtg aaacaattct                                                   20


<210> 26863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26863
accctagtat ccttacccct                                                   20


<210> 26864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26864
aggactggta gataaaaccc                                                   20


<210> 26865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26865
ccaataaggg acaggactgg                                                   20


<210> 26866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26866
caaccaataa gggacaggac                                                   20


<210> 26867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26867
accgtcaacc aataagggac                                                   20


<210> 26868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26868
aaccgtcaac caataaggga                                                   20


<210> 26869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26869
ggacaaccgt caaccaataa                                                   20


<210> 26870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26870
aggacaaccg tcaaccaata                                                   20


<210> 26871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26871
caggacaacc gtcaaccaat                                                   20


<210> 26872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26872
ttctgtagag ttaaaatccc                                                   20


<210> 26873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26873
gttctgtaga gttaaaatcc                                                   20


<210> 26874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26874
ccactgaagt aagttctgta                                                   20


<210> 26875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26875
ggccactgaa gtaagttctg                                                   20


<210> 26876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26876
ctttctctgg ccactgaagt                                                   20


<210> 26877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26877
agggctttct ctggccactg                                                   20


<210> 26878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26878
tgtctgccca gggctttctc                                                   20


<210> 26879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26879
ttcctgcctc tgtctgccca                                                   20


<210> 26880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26880
cttcctgcct ctgtctgccc                                                   20


<210> 26881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26881
acttcctgcc tctgtctgcc                                                   20


<210> 26882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26882
tctagaccag aggtcaccag                                                   20


<210> 26883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26883
ggatctagac cagaggtcac                                                   20


<210> 26884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26884
ttcccaggga tctagaccag                                                   20


<210> 26885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26885
tttcccaggg atctagacca                                                   20


<210> 26886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26886
catttcccag ggatctagac                                                   20


<210> 26887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26887
ttgctcattt cccagggatc                                                   20


<210> 26888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26888
tgcaccttgc tcatttccca                                                   20


<210> 26889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26889
ctgcaccttg ctcatttccc                                                   20


<210> 26890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26890
tctgcacctt gctcatttcc                                                   20


<210> 26891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26891
aattaaggtt gcaaggacta                                                   20


<210> 26892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26892
gattcccaat taaggttgca                                                   20


<210> 26893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26893
ggattcccaa ttaaggttgc                                                   20


<210> 26894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26894
aaaataggga ttcccaatta                                                   20


<210> 26895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26895
taaaataggg attcccaatt                                                   20


<210> 26896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26896
ttcaactaga ctctaaaata                                                   20


<210> 26897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26897
attcaactag actctaaaat                                                   20


<210> 26898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26898
cattcaacta gactctaaaa                                                   20


<210> 26899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26899
ctttccccac tacattcaac                                                   20


<210> 26900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26900
ttgatatggc tacctcacaa                                                   20


<210> 26901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26901
tttgatatgg ctacctcaca                                                   20


<210> 26902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26902
tataacacat acatttgata                                                   20


<210> 26903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26903
caagaagtga gtatcaggcc                                                   20


<210> 26904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26904
taatccaaga agtgagtatc                                                   20


<210> 26905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26905
ttaatccaag aagtgagtat                                                   20


<210> 26906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26906
cagccattaa tccaagaagt                                                   20


<210> 26907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26907
tcctcagcca ttaatccaag                                                   20


<210> 26908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26908
tcctcctcag ccattaatcc                                                   20


<210> 26909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26909
ttcttggatt gtctcctcct                                                   20


<210> 26910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26910
aaactagaat agatatttct                                                   20


<210> 26911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26911
agcttggagc taaactagaa                                                   20


<210> 26912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26912
ggccgagctt ggagctaaac                                                   20


<210> 26913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26913
gaaagccagg gccgagcttg                                                   20


<210> 26914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26914
ttgaaagcca gggccgagct                                                   20


<210> 26915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26915
actgtttgaa agccagggcc                                                   20


<210> 26916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26916
tgcagactgt ttgaaagcca                                                   20


<210> 26917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26917
atgcagactg tttgaaagcc                                                   20


<210> 26918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26918
catgcagact gtttgaaagc                                                   20


<210> 26919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26919
aactcatgca gactgtttga                                                   20


<210> 26920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26920
tatacctgca aaaactcatg                                                   20


<210> 26921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26921
ggaacagcta ttaaacttaa                                                   20


<210> 26922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26922
aggaacagct attaaactta                                                   20


<210> 26923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26923
caggaacagc tattaaactt                                                   20


<210> 26924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26924
aaaggcttgc ttagcaggaa                                                   20


<210> 26925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26925
aatagaaagg cttgcttagc                                                   20


<210> 26926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26926
gaatagaaag gcttgcttag                                                   20


<210> 26927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26927
accgaataga aaggcttgct                                                   20


<210> 26928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26928
tgaatgccca ccgaatagaa                                                   20


<210> 26929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26929
ctgaatgccc accgaataga                                                   20


<210> 26930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26930
agggctgaat gcccaccgaa                                                   20


<210> 26931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26931
gctgttggtt catcttggga                                                   20


<210> 26932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26932
cgctgttggt tcatcttggg                                                   20


<210> 26933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26933
tcgctgttgg ttcatcttgg                                                   20


<210> 26934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26934
tatcgctgtt ggttcatctt                                                   20


<210> 26935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26935
atatcgctgt tggttcatct                                                   20


<210> 26936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26936
ggggaaccaa atatcgctgt                                                   20


<210> 26937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26937
aaaaaaaaaa aggaggcaag                                                   20


<210> 26938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26938
aaaaaaaaaa aaggaggcaa                                                   20


<210> 26939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26939
aaaaaaaaaa aaaggaggca                                                   20


<210> 26940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26940
aaaaaaaaaa aaaaggaggc                                                   20


<210> 26941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26941
aaaaaaaaaa aaaaaaaagg                                                   20


<210> 26942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26942
aaaaaaaaaa aaaaaaaaag                                                   20


<210> 26943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26943
aaaaaaaaaa aaaaaaaaaa                                                   20


<210> 26944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26944
caaaaaaaaa aaaaaaaaaa                                                   20


<210> 26945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26945
tccagcctgg acaacagagt                                                   20


<210> 26946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26946
gcactccagc ctggacaaca                                                   20


<210> 26947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26947
ctgcactcca gcctggacaa                                                   20


<210> 26948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26948
tgtgccactg cactccagcc                                                   20


<210> 26949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26949
gtgattgtgc cactgcactc                                                   20


<210> 26950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26950
tgggaggtca aggctgcaat                                                   20


<210> 26951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26951
cacttgaaca tgggaggtca                                                   20


<210> 26952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26952
tcacttgaac atgggaggtc                                                   20


<210> 26953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26953
gaggatcact tgaacatggg                                                   20


<210> 26954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26954
ggaggatcac ttgaacatgg                                                   20


<210> 26955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26955
tgggaggatc acttgaacat                                                   20


<210> 26956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26956
gtgggaggat cacttgaaca                                                   20


<210> 26957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26957
acttgggagg ctgaggtggg                                                   20


<210> 26958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26958
tacttgggag gctgaggtgg                                                   20


<210> 26959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26959
actacttggg aggctgaggt                                                   20


<210> 26960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26960
cactacttgg gaggctgagg                                                   20


<210> 26961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26961
ttccactact tgggaggctg                                                   20


<210> 26962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26962
gttccactac ttgggaggct                                                   20


<210> 26963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26963
ctgtagttcc actacttggg                                                   20


<210> 26964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26964
cctgtagttc cactacttgg                                                   20


<210> 26965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26965
tacctgtagt tccactactt                                                   20


<210> 26966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26966
atacctgtag ttccactact                                                   20


<210> 26967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26967
ggcgtggtgg cacatacctg                                                   20


<210> 26968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26968
tgaagattag ccaggcgtgg                                                   20


<210> 26969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26969
atatgaagat tagccaggcg                                                   20


<210> 26970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26970
caaaaatatg aagattagcc                                                   20


<210> 26971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26971
tcaaaaatat gaagattagc                                                   20


<210> 26972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26972
cccatcaaaa atatgaagat                                                   20


<210> 26973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26973
aaaaccccat caaaaatatg                                                   20


<210> 26974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26974
tgagaccagc ctggggaaca                                                   20


<210> 26975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (-) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26975
aggagtttga gaccagcctg                                                   20


<210> 26976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26976
attgtttgaa ttttattcta                                                   20


<210> 26977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26977
tttgaatttt attctatggc                                                   20


<210> 26978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26978
ttgaatttta ttctatggcc                                                   20


<210> 26979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 26979
ttattctatg gccaggcata                                                   20


<210> 26980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26980
tacttgtatt tgtacccttt                                                   20


<210> 26981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26981
ttgtaccctt ttggtaacct                                                   20


<210> 26982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26982
tgtacccttt tggtaacctt                                                   20


<210> 26983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26983
tggtaacctt aggttttgtg                                                   20


<210> 26984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26984
tttgtgtggc tttctgtaaa                                                   20


<210> 26985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26985
ttgactgaca ctctttttcc                                                   20


<210> 26986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26986
gactgacact ctttttccca                                                   20


<210> 26987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 26987
ttctgtatgt ctctatatcc                                                   20


<210> 26988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 26988
tctgtatgtc tctatatccc                                                   20


<210> 26989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 26989
tttaattatt attatacttt                                                   20


<210> 26990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26990
tattattata ctttaagttt                                                   20


<210> 26991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26991
attattatac tttaagtttt                                                   20


<210> 26992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26992
ctttaagttt taggatacat                                                   20


<210> 26993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 26993
ggatacatga gcacaacgtg                                                   20


<210> 26994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26994
gatacatgag cacaacgtgc                                                   20


<210> 26995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 26995
tatgtataca tgtgccatgt                                                   20


<210> 26996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 26996
cattaacttg tcatttacat                                                   20


<210> 26997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 26997
attaacttgt catttacatt                                                   20


<210> 26998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 26998
ctccacccca caactgtccc                                                   20


<210> 26999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 26999
attgttcaat tcccacctat                                                   20


<210> 27000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27000
ttcaattccc acctatgagt                                                   20


<210> 27001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27001
cacctatgag tgagaacatg                                                   20


<210> 27002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27002
gagtgagaac atgcggtgtt                                                   20


<210> 27003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27003
ggtttttttt gtccttgcga                                                   20


<210> 27004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27004
tgtccttgcg atagtttgct                                                   20


<210> 27005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27005
cgatagtttg ctgagaatga                                                   20


<210> 27006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27006
ttgctgagaa tgatggtttc                                                   20


<210> 27007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27007
gcttcatcca tgtccctgca                                                   20


<210> 27008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27008
cttcatccat gtccctgcaa                                                   20


<210> 27009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27009
catgaactca tcatttttta                                                   20


<210> 27010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27010
catcattttt tatggctgca                                                   20


<210> 27011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27011
tatggctgca tagtattcca                                                   20


<210> 27012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27012
tgtgccacat tttcttaatc                                                   20


<210> 27013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27013
ttaatccagt ctatcactgt                                                   20


<210> 27014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27014
gtctatcact gttggacatt                                                   20


<210> 27015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27015
tctatcactg ttggacattt                                                   20


<210> 27016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27016
tcactgttgg acatttgggt                                                   20


<210> 27017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27017
tggacatttg ggttggttcc                                                   20


<210> 27018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27018
caagtctttg ctattgtgaa                                                   20


<210> 27019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27019
tacgtgtgca tgtgtcttta                                                   20


<210> 27020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27020
gtgtgcatgt gtctttatag                                                   20


<210> 27021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27021
cagtatgatt tataatcctt                                                   20


<210> 27022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27022
agtatgattt ataatccttt                                                   20


<210> 27023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27023
taatcctttg ggtatatacc                                                   20


<210> 27024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27024
tttgggtata tacccagtaa                                                   20


<210> 27025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27025
ttgggtatat acccagtaat                                                   20


<210> 27026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27026
gtatataccc agtaatggga                                                   20


<210> 27027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27027
atacccagta atgggatggc                                                   20


<210> 27028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27028
tacccagtaa tgggatggct                                                   20


<210> 27029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27029
aatgggatgg ctgggtcaaa                                                   20


<210> 27030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27030
gctgggtcaa atggtatttc                                                   20


<210> 27031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27031
tcaaatggta tttctggttc                                                   20


<210> 27032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27032
atttctggtt ctagatccct                                                   20


<210> 27033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27033
tttctggttc tagatccctg                                                   20


<210> 27034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27034
gacttccaca atgattgaac                                                   20


<210> 27035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27035
acaatgattg aactagttta                                                   20


<210> 27036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27036
ctagtttaca gacccaccaa                                                   20


<210> 27037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27037
cagacccacc aacagtgtaa                                                   20


<210> 27038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27038
ctatttctcc acatcctctc                                                   20


<210> 27039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27039
ttaatgatcg ccattctaac                                                   20


<210> 27040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27040
atcgccattc taactggtgt                                                   20


<210> 27041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27041
ccattctaac tggtgtgaga                                                   20


<210> 27042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27042
tgtgagatgg tatctcattg                                                   20


<210> 27043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27043
tttgatttgc atttctctga                                                   20


<210> 27044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27044
atttgcattt ctctgatggc                                                   20


<210> 27045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27045
ctctgatggc cagtgatgat                                                   20


<210> 27046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27046
gcattttttc atgtgttttt                                                   20


<210> 27047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27047
ctgcataaat gtcttctttt                                                   20


<210> 27048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27048
cataaatgtc ttcttttgag                                                   20


<210> 27049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27049
atccttcgcc cactttttga                                                   20


<210> 27050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27050
tccttcgccc actttttgat                                                   20


<210> 27051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27051
ttttccttgt aaatttgttt                                                   20


<210> 27052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27052
aaatttgttt gagttcattg                                                   20


<210> 27053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27053
tttgagttca ttgtagattc                                                   20


<210> 27054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27054
tcattgtaga ttctggatat                                                   20


<210> 27055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27055
tctggatatt agcccttcgt                                                   20


<210> 27056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27056
atattagccc ttcgtcagat                                                   20


<210> 27057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27057
ttagcccttc gtcagatgag                                                   20


<210> 27058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27058
tagcccttcg tcagatgagt                                                   20


<210> 27059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27059
aaaaattttc tcccatcctg                                                   20


<210> 27060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27060
aaaattttct cccatcctgt                                                   20


<210> 27061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27061
taggtttctg ttcactctga                                                   20


<210> 27062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27062
gtttctgttc actctgatgg                                                   20


<210> 27063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27063
tggtggtttc ttttgctgct                                                   20


<210> 27064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27064
tggtttcttt tgctgctcag                                                   20


<210> 27065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27065
tttgctgctc agaagctctt                                                   20


<210> 27066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27066
cagaagctct ttagtttaat                                                   20


<210> 27067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27067
acttttgttg ccattgcttt                                                   20


<210> 27068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27068
tgccattgct tttggtgttt                                                   20


<210> 27069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27069
cttttggtgt tttagacatg                                                   20


<210> 27070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27070
gcccatgcct atgtcctgaa                                                   20


<210> 27071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27071
atgtcctgaa tggtattgcc                                                   20


<210> 27072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27072
tgtcctgaat ggtattgcct                                                   20


<210> 27073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27073
gtattgccta ggttctcttc                                                   20


<210> 27074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27074
tattgcctag gttctcttct                                                   20


<210> 27075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27075
attgcctagg ttctcttcta                                                   20


<210> 27076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27076
gttctcttct agggttttta                                                   20


<210> 27077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27077
ttctagggtt tttatggttt                                                   20


<210> 27078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27078
tctagggttt ttatggtttt                                                   20


<210> 27079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27079
tggttttagg tctaacattt                                                   20


<210> 27080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27080
tcttgaatta atttttgtat                                                   20


<210> 27081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27081
cttgaattaa tttttgtata                                                   20


<210> 27082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27082
ttaatttttg tataaggtgt                                                   20


<210> 27083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27083
taatttttgt ataaggtgta                                                   20


<210> 27084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27084
tttttgtata aggtgtaagg                                                   20


<210> 27085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27085
ttttgtataa ggtgtaagga                                                   20


<210> 27086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27086
tttgtataag gtgtaaggaa                                                   20


<210> 27087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27087
taaggtgtaa ggaagggatc                                                   20


<210> 27088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27088
gtaaggaagg gatccagttt                                                   20


<210> 27089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27089
cagtttcagc tttctccata                                                   20


<210> 27090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27090
ttcagctttc tccatatggc                                                   20


<210> 27091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27091
gctttctcca tatggctagc                                                   20


<210> 27092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27092
atatggctag ccagttttcc                                                   20


<210> 27093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27093
tcccagcacc atttattaaa                                                   20


<210> 27094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27094
cccagcacca tttattaaat                                                   20


<210> 27095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27095
ccagcaccat ttattaaata                                                   20


<210> 27096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27096
tccccatttc ttgtttttgt                                                   20


<210> 27097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27097
ccccatttct tgtttttgtc                                                   20


<210> 27098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27098
tgtttttgtc aggtttgtca                                                   20


<210> 27099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27099
ttgtcaggtt tgtcaaagat                                                   20


<210> 27100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27100
caggtttgtc aaagatcaga                                                   20


<210> 27101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27101
tgtcaaagat cagatagttg                                                   20


<210> 27102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27102
atcagatagt tgtagatatg                                                   20


<210> 27103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27103
agatatgcgg cattatttct                                                   20


<210> 27104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27104
gatatgcggc attatttctg                                                   20


<210> 27105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27105
atatgcggca ttatttctga                                                   20


<210> 27106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27106
agggctctgt tctgttccat                                                   20


<210> 27107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27107
attggtctat atctctgttt                                                   20


<210> 27108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27108
ctatatctct gttttggtac                                                   20


<210> 27109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27109
gtaccagtac catgctgttt                                                   20


<210> 27110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27110
ccatgctgtt ttggttactg                                                   20


<210> 27111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27111
gttactgtag ccttgtaata                                                   20


<210> 27112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27112
tagccttgta atatagtttg                                                   20


<210> 27113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27113
cttgtaatat agtttgaagt                                                   20


<210> 27114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27114
ttgtaatata gtttgaagtc                                                   20


<210> 27115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27115
taatatagtt tgaagtcagg                                                   20


<210> 27116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27116
gtcaggtagc gtgatgcctc                                                   20


<210> 27117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27117
gctttgttat acaccaataa                                                   20


<210> 27118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27118
atacaccaat aacagacaaa                                                   20


<210> 27119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27119
acaccaataa cagacaaaca                                                   20


<210> 27120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27120
accaataaca gacaaacaga                                                   20


<210> 27121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27121
caaacagaga gccaaatcat                                                   20


<210> 27122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27122
tcccattcac aattgcttca                                                   20


<210> 27123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27123
ccattcacaa ttgcttcaaa                                                   20


<210> 27124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27124
ttcaaagaga ataaaatacc                                                   20


<210> 27125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27125
tcaaagagaa taaaatacct                                                   20


<210> 27126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27126
tacctaggaa tgcaacttac                                                   20


<210> 27127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27127
acctaggaat gcaacttaca                                                   20


<210> 27128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27128
cctaggaatg caacttacaa                                                   20


<210> 27129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27129
tgcaacttac aagggatgtg                                                   20


<210> 27130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27130
gcaacttaca agggatgtga                                                   20


<210> 27131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27131
gggatgtgaa ggacctcttc                                                   20


<210> 27132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27132
ggatgtgaag gacctcttca                                                   20


<210> 27133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27133
atgtgaagga cctcttcaag                                                   20


<210> 27134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27134
gagaactaca aaccactgct                                                   20


<210> 27135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27135
accactgctc agtgaaataa                                                   20


<210> 27136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27136
cactgctcag tgaaataaaa                                                   20


<210> 27137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27137
actgctcagt gaaataaaag                                                   20


<210> 27138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27138
taaaagagga tacaaacaaa                                                   20


<210> 27139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27139
aagaggatac aaacaaatgg                                                   20


<210> 27140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27140
ggaagaatac tccatgctca                                                   20


<210> 27141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27141
gaagaatact ccatgctcat                                                   20


<210> 27142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27142
gaatactcca tgctcatggg                                                   20


<210> 27143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27143
aatactccat gctcatgggt                                                   20


<210> 27144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27144
actccatgct catgggtagg                                                   20


<210> 27145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27145
aagaatcaat atcttgaaaa                                                   20


<210> 27146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27146
tgaaaatggc catactgccc                                                   20


<210> 27147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27147
gaaaatggcc atactgccca                                                   20


<210> 27148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27148
atactgccca aggtaattta                                                   20


<210> 27149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27149
gattcaatgc catccccatc                                                   20


<210> 27150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27150
gctaccaatg actttcttct                                                   20


<210> 27151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27151
aatgactttc ttctcagaat                                                   20


<210> 27152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27152
aattggaaaa aactacttta                                                   20


<210> 27153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27153
aaactacttt aaagttcata                                                   20


<210> 27154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27154
aagttcatac ggaaccaaaa                                                   20


<210> 27155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27155
gttcatacgg aaccaaaaaa                                                   20


<210> 27156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27156
aaaaaagagc ccacattgcc                                                   20


<210> 27157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27157
tttaacctta cttttttgat                                                   20


<210> 27158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27158
ttgattggct aattgtttct                                                   20


<210> 27159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27159
tggctaattg tttcttagca                                                   20


<210> 27160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27160
agttccccct tgtcctactt                                                   20


<210> 27161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27161
ctctatttct gatttgttac                                                   20


<210> 27162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27162
tactggcaac cctaataatt                                                   20


<210> 27163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27163
taattaagtc attcattctt                                                   20


<210> 27164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27164
tcattcattc ttaagttaca                                                   20


<210> 27165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27165
ctttactttt ttttactttt                                                   20


<210> 27166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27166
ttttttttac tttttagcat                                                   20


<210> 27167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27167
tttttttact ttttagcatt                                                   20


<210> 27168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27168
tttttacttt ttagcattag                                                   20


<210> 27169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27169
attaggagaa atacctaatg                                                   20


<210> 27170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27170
gaaataccta atgtagatga                                                   20


<210> 27171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27171
aaatacctaa tgtagatgac                                                   20


<210> 27172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27172
taatgtagat gacgggttga                                                   20


<210> 27173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27173
aatgtagatg acgggttgat                                                   20


<210> 27174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27174
agatgacggg ttgatgggtg                                                   20


<210> 27175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27175
atgggtgcag caaaccaaca                                                   20


<210> 27176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27176
tacattgtgc acatgtaccc                                                   20


<210> 27177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27177
cacatgtacc ctagaattta                                                   20


<210> 27178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27178
ttaaagtata attttaaaaa                                                   20


<210> 27179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27179
aattttaaaa aaagaaaaaa                                                   20


<210> 27180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27180
attttaaaaa aagaaaaaaa                                                   20


<210> 27181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27181
ttaatttatt tgtaaacctt                                                   20


<210> 27182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27182
gtaaaccttc agcctgtgtt                                                   20


<210> 27183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27183
cttcagcctg tgttcagctc                                                   20


<210> 27184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27184
ctgtgttcag ctccagactg                                                   20


<210> 27185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27185
tatcttgcat ccctaacact                                                   20


<210> 27186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27186
atcttgcatc cctaacactt                                                   20


<210> 27187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27187
tgcatcccta acacttagga                                                   20


<210> 27188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27188
agtgacttca cttttgtctt                                                   20


<210> 27189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27189
tttgtcttaa gcaaatgctc                                                   20


<210> 27190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27190
aagcaaatgc tccagcacac                                                   20


<210> 27191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27191
agcaaatgct ccagcacacc                                                   20


<210> 27192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27192
gcaaatgctc cagcacacca                                                   20


<210> 27193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27193
gatacctact attctgtgtt                                                   20


<210> 27194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27194
acctactatt ctgtgttaag                                                   20


<210> 27195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27195
atctgtgtct atgtgttatg                                                   20


<210> 27196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27196
ctatgtgtta tgcagtttaa                                                   20


<210> 27197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27197
atgcagttta atggtataaa                                                   20


<210> 27198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27198
agtttaatgg tataaaaagt                                                   20


<210> 27199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27199
gtttaatggt ataaaaagtt                                                   20


<210> 27200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27200
tttaatggta taaaaagtta                                                   20


<210> 27201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27201
aatggtataa aaagttaggg                                                   20


<210> 27202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27202
aaaagttagg gcggtgttta                                                   20


<210> 27203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27203
agttagggcg gtgtttatgg                                                   20


<210> 27204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27204
ttagggcggt gtttatggtg                                                   20


<210> 27205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27205
tagggcggtg tttatggtgg                                                   20


<210> 27206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27206
tatggtggag gcatactttt                                                   20


<210> 27207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27207
ggcatacttt tgagaacttg                                                   20


<210> 27208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27208
gcatactttt gagaacttgc                                                   20


<210> 27209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27209
ttttgagaac ttgcaggttc                                                   20


<210> 27210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27210
gcaggttcca gatatttgta                                                   20


<210> 27211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27211
gttccagata tttgtacagt                                                   20


<210> 27212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27212
tcctgtctct tatctccctt                                                   20


<210> 27213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27213
tcttatctcc cttcagtgct                                                   20


<210> 27214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27214
cttatctccc ttcagtgcta                                                   20


<210> 27215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27215
gctaaggtat cctcacattc                                                   20


<210> 27216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27216
ctaaggtatc ctcacattct                                                   20


<210> 27217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27217
ggtatcctca cattctgggc                                                   20


<210> 27218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27218
tatcctcaca ttctgggcca                                                   20


<210> 27219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27219
tcctcacatt ctgggccaga                                                   20


<210> 27220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27220
attctgggcc agagagattc                                                   20


<210> 27221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27221
gattctagtt ttacctcttg                                                   20


<210> 27222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27222
attctagttt tacctcttgt                                                   20


<210> 27223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27223
ctagttttac ctcttgtggg                                                   20


<210> 27224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27224
tagttttacc tcttgtgggt                                                   20


<210> 27225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27225
agttttacct cttgtgggtg                                                   20


<210> 27226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27226
tacctcttgt gggtggggtt                                                   20


<210> 27227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27227
ctcttgtggg tggggttgag                                                   20


<210> 27228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27228
tcttgtgggt ggggttgaga                                                   20


<210> 27229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27229
tgtgggtggg gttgagaagg                                                   20


<210> 27230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27230
tggggttgag aaggtagctc                                                   20


<210> 27231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27231
gagaaggtag ctctggttct                                                   20


<210> 27232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27232
agaaggtagc tctggttctc                                                   20


<210> 27233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27233
ggtagctctg gttctcaggt                                                   20


<210> 27234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27234
ggttctcagg ttggctccca                                                   20


<210> 27235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27235
ggttggctcc catggaaatc                                                   20


<210> 27236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27236
ctaccttgta attgtaccac                                                   20


<210> 27237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27237
taccttgtaa ttgtaccacc                                                   20


<210> 27238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27238
attgtaccac caggtgaact                                                   20


<210> 27239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27239
caccaggtga acttggaaac                                                   20


<210> 27240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27240
gtgaacttgg aaactggctc                                                   20


<210> 27241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27241
ggctctagtg aaattttcaa                                                   20


<210> 27242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27242
tcaaaagata atcttgcatt                                                   20


<210> 27243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27243
ccaaaaactc cgtgtcatgc                                                   20


<210> 27244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27244
caatgtttcc cattacaatt                                                   20


<210> 27245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27245
aatgtttccc attacaattt                                                   20


<210> 27246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27246
atttaggaaa tgcatttgtg                                                   20


<210> 27247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27247
tgcatttgtg cagaaaaaat                                                   20


<210> 27248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27248
tgtgcagaaa aaatgagaaa                                                   20


<210> 27249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27249
agaaaaaatg agaaatggat                                                   20


<210> 27250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27250
gagaaatgga ttagtttccc                                                   20


<210> 27251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27251
agaaatggat tagtttccct                                                   20


<210> 27252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27252
gggatgctgt aacaaattac                                                   20


<210> 27253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27253
tgtaacaaat taccagaaac                                                   20


<210> 27254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27254
gtaacaaatt accagaaact                                                   20


<210> 27255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27255
acaaattacc agaaactagg                                                   20


<210> 27256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27256
aactaggtag atgacaataa                                                   20


<210> 27257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27257
atttattctc ttacacttct                                                   20


<210> 27258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27258
tttattctct tacacttctg                                                   20


<210> 27259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27259
ttctcttaca cttctgaggc                                                   20


<210> 27260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27260
gaggctagat gtctaaaatc                                                   20


<210> 27261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27261
aggctagatg tctaaaatca                                                   20


<210> 27262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27262
gatgtctaaa atcaaggtat                                                   20


<210> 27263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27263
gtctaaaatc aaggtattgg                                                   20


<210> 27264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27264
ctaaaatcaa ggtattggca                                                   20


<210> 27265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27265
gcagagccat gttccctctg                                                   20


<210> 27266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27266
catgttccct ctgaagcccg                                                   20


<210> 27267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27267
atgttccctc tgaagcccgc                                                   20


<210> 27268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27268
tccctctgaa gcccgcaggt                                                   20


<210> 27269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27269
ttgccttcca tgtctcctcc                                                   20


<210> 27270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27270
tccatgtctc ctcctagctt                                                   20


<210> 27271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27271
cagcaatctt tgccattcct                                                   20


<210> 27272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27272
tttcttcctg tgtctccata                                                   20


<210> 27273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27273
tttttttctg catcttccca                                                   20


<210> 27274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27274
ttcaaattcc cctcatattt                                                   20


<210> 27275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27275
ccctcatatt ttagcaacac                                                   20


<210> 27276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27276
attttagcaa caccagtcat                                                   20


<210> 27277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27277
agcaacacca gtcattggat                                                   20


<210> 27278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27278
gcaacaccag tcattggatt                                                   20


<210> 27279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27279
caacaccagt cattggatta                                                   20


<210> 27280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27280
caaaaacctt aatgtcaaat                                                   20


<210> 27281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27281
aaaaacctta atgtcaaata                                                   20


<210> 27282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27282
gtcaaataag gtcacaatca                                                   20


<210> 27283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27283
tcaaataagg tcacaatcac                                                   20


<210> 27284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27284
gtcacaatca caggtactat                                                   20


<210> 27285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27285
caatcacagg tactattggt                                                   20


<210> 27286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27286
agaacttcaa catacccttt                                                   20


<210> 27287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27287
gaacttcaac ataccctttt                                                   20


<210> 27288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27288
aacttcaaca taccctttta                                                   20


<210> 27289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27289
agggaacatt attcaaccca                                                   20


<210> 27290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27290
ccaaagcata attcaacata                                                   20


<210> 27291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27291
ttgaattatg ttcctatgtt                                                   20


<210> 27292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27292
tgaattatgt tcctatgttt                                                   20


<210> 27293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27293
gaattatgtt cctatgttta                                                   20


<210> 27294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27294
attatgttcc tatgtttagg                                                   20


<210> 27295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27295
agggagcata attcaactca                                                   20


<210> 27296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27296
ctcaaagtaa aaatactttt                                                   20


<210> 27297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27297
agtaaaaata cttttgagaa                                                   20


<210> 27298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27298
aatagtatca tctgctttaa                                                   20


<210> 27299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27299
atcatctgct ttaatagaac                                                   20


<210> 27300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27300
ctttaataga accagtctga                                                   20


<210> 27301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27301
atagaaccag tctgatggtt                                                   20


<210> 27302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27302
gcccaaactc tctgtccact                                                   20


<210> 27303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27303
ttagctgtct tataaacact                                                   20


<210> 27304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27304
tagctgtctt ataaacactt                                                   20


<210> 27305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27305
tgtcttataa acacttgggc                                                   20


<210> 27306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27306
aaacacttgg gctagtatct                                                   20


<210> 27307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27307
acttgggcta gtatctcaga                                                   20


<210> 27308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27308
tggctttttc atcatccaca                                                   20


<210> 27309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27309
ggctttttca tcatccacat                                                   20


<210> 27310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27310
ttcatcatcc acatgggatt                                                   20


<210> 27311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27311
cacatgggat ttagacgttg                                                   20


<210> 27312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27312
atgggattta gacgttgaag                                                   20


<210> 27313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27313
tagacgttga agaagctgca                                                   20


<210> 27314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27314
cgttgaagaa gctgcacagt                                                   20


<210> 27315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27315
acagtcagta tctgtgctcc                                                   20


<210> 27316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27316
cagtcagtat ctgtgctccc                                                   20


<210> 27317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27317
agtatctgtg ctcccgggtt                                                   20


<210> 27318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27318
atctgtgctc ccgggttcag                                                   20


<210> 27319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27319
gctcccgggt tcagtggtac                                                   20


<210> 27320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27320
tcccgggttc agtggtacga                                                   20


<210> 27321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27321
ccgggttcag tggtacgaga                                                   20


<210> 27322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27322
cgggttcagt ggtacgagag                                                   20


<210> 27323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27323
gttcagtggt acgagagagg                                                   20


<210> 27324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27324
tcagtggtac gagagaggaa                                                   20


<210> 27325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27325
acgagagagg aagagttatt                                                   20


<210> 27326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27326
atttggttga actcatcttt                                                   20


<210> 27327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27327
actcatcttt tagaataaat                                                   20


<210> 27328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27328
ctcatctttt agaataaatc                                                   20


<210> 27329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27329
tttagaataa atcaggcatt                                                   20


<210> 27330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27330
tagaataaat caggcattca                                                   20


<210> 27331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27331
taaatcaggc attcagagaa                                                   20


<210> 27332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27332
attcagagaa tagctgattt                                                   20


<210> 27333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27333
agagaatagc tgatttgaga                                                   20


<210> 27334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27334
atagctgatt tgagatggct                                                   20


<210> 27335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27335
atcttattaa cctgcatctg                                                   20


<210> 27336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27336
ctgtggatgc tgccaactcc                                                   20


<210> 27337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27337
ggatgctgcc aactcccagt                                                   20


<210> 27338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27338
caactcccag taagcatctt                                                   20


<210> 27339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27339
actcccagta agcatcttga                                                   20


<210> 27340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27340
agagcctctt tgacttctta                                                   20


<210> 27341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27341
gagcctcttt gacttcttat                                                   20


<210> 27342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27342
tttgacttct tatgggctaa                                                   20


<210> 27343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27343
ttcttatggg ctaatagtga                                                   20


<210> 27344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27344
atgggctaat agtgacagaa                                                   20


<210> 27345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27345
tgggctaata gtgacagaaa                                                   20


<210> 27346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27346
gggctaatag tgacagaaaa                                                   20


<210> 27347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27347
gctaatagtg acagaaaagg                                                   20


<210> 27348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27348
taatagtgac agaaaaggga                                                   20


<210> 27349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27349
agtgacagaa aagggagagc                                                   20


<210> 27350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27350
gtgacagaaa agggagagca                                                   20


<210> 27351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27351
gaaaagggag agcaaggcct                                                   20


<210> 27352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27352
ctcggcaaat ctgtattctt                                                   20


<210> 27353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27353
tcggcaaatc tgtattcttg                                                   20


<210> 27354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27354
tctgtattct tgaggcatgt                                                   20


<210> 27355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27355
ttgaggcatg tgagatgtat                                                   20


<210> 27356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27356
gtgctttgta attatacaaa                                                   20


<210> 27357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27357
ttatgaaatg atcaaatata                                                   20


<210> 27358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27358
caaatatata gacaatgaat                                                   20


<210> 27359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27359
tatttgaatc tttgtgattg                                                   20


<210> 27360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27360
tgaatctttg tgattgtggc                                                   20


<210> 27361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27361
gaatctttgt gattgtggct                                                   20


<210> 27362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27362
tttgtgattg tggctgggaa                                                   20


<210> 27363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27363
ttgtgattgt ggctgggaat                                                   20


<210> 27364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27364
attgtggctg ggaatgggcc                                                   20


<210> 27365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27365
tgtggctggg aatgggccaa                                                   20


<210> 27366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27366
gggaatgggc caagagttaa                                                   20


<210> 27367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27367
aatgggccaa gagttaatgg                                                   20


<210> 27368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27368
ccctatgtcc tatgttgtta                                                   20


<210> 27369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27369
cctatgtcct atgttgttat                                                   20


<210> 27370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27370
ctatgtccta tgttgttata                                                   20


<210> 27371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27371
atgtcctatg ttgttatagg                                                   20


<210> 27372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27372
caaaatctgc aacatgcctt                                                   20


<210> 27373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27373
ctgacaattc ttactccatt                                                   20


<210> 27374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27374
agttcataca attaatcttt                                                   20


<210> 27375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27375
gttcatacaa ttaatctttt                                                   20


<210> 27376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27376
ttcatacaat taatcttttg                                                   20


<210> 27377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27377
tcatacaatt aatcttttgg                                                   20


<210> 27378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27378
cctattttat ctcttgttct                                                   20


<210> 27379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27379
tattttatct cttgttcttg                                                   20


<210> 27380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27380
tttatctctt gttcttggag                                                   20


<210> 27381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27381
ttggagcagt gcccatcata                                                   20


<210> 27382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27382
tacgtaatta ataacatttg                                                   20


<210> 27383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27383
acgtaattaa taacatttgc                                                   20


<210> 27384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27384
aacatttgca ggatgaatga                                                   20


<210> 27385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27385
ggatgaatga aagaaactac                                                   20


<210> 27386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27386
tggccatacc ttttatctac                                                   20


<210> 27387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27387
tcttctgatt atattaacta                                                   20


<210> 27388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27388
ttctgattat attaactatg                                                   20


<210> 27389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27389
ttatattaac tatggagttc                                                   20


<210> 27390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27390
aactatggag ttctggacgc                                                   20


<210> 27391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27391
actatggagt tctggacgcc                                                   20


<210> 27392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27392
cctccttaat gtctgattat                                                   20


<210> 27393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27393
gtctgattat gagatgtgaa                                                   20


<210> 27394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27394
tatgagatgt gaacagactc                                                   20


<210> 27395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27395
agactctgga atgtattcaa                                                   20


<210> 27396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27396
gtattcaaaa gctgcctctt                                                   20


<210> 27397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27397
ctgcctcttt agctacacaa                                                   20


<210> 27398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27398
ctctttagct acacaacaga                                                   20


<210> 27399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27399
tctttagcta cacaacagaa                                                   20


<210> 27400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27400
agctacacaa cagaaaggtc                                                   20


<210> 27401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27401
acagaaaggt ccagccattt                                                   20


<210> 27402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27402
aggtccagcc atttcagcct                                                   20


<210> 27403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27403
cagccatttc agcctcagaa                                                   20


<210> 27404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27404
gccatttcag cctcagaaaa                                                   20


<210> 27405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27405
gagtgctttt cccatataaa                                                   20


<210> 27406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27406
agtgcttttc ccatataaat                                                   20


<210> 27407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27407
gtgcttttcc catataaatg                                                   20


<210> 27408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27408
cttttcccat ataaatgggg                                                   20


<210> 27409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27409
ttttcccata taaatggggc                                                   20


<210> 27410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27410
tataaatggg gcaggcacca                                                   20


<210> 27411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27411
taaatggggc aggcaccatg                                                   20


<210> 27412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27412
gcaggcacca tggagttcta                                                   20


<210> 27413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27413
accatggagt tctacagcac                                                   20


<210> 27414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27414
gttctacagc acgagatgcg                                                   20


<210> 27415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27415
agcacgagat gcgaagtcta                                                   20


<210> 27416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27416
cgagatgcga agtctataga                                                   20


<210> 27417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27417
tcccttccca ccaattttac                                                   20


<210> 27418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27418
ttcccaccaa ttttacaagt                                                   20


<210> 27419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27419
tcccaccaat tttacaagtg                                                   20


<210> 27420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27420
ttttacaagt gaggaaattg                                                   20


<210> 27421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27421
caagtgagga aattgaagtt                                                   20


<210> 27422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27422
agtgaggaaa ttgaagttaa                                                   20


<210> 27423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27423
gtgaggaaat tgaagttaag                                                   20


<210> 27424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27424
tgaggaaatt gaagttaaga                                                   20


<210> 27425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27425
gaggaaattg aagttaagag                                                   20


<210> 27426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27426
aaattgaagt taagagggga                                                   20


<210> 27427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27427
agttaagagg ggaaagactt                                                   20


<210> 27428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27428
gaggggaaag actttagccc                                                   20


<210> 27429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27429
ggaaagactt tagccctggt                                                   20


<210> 27430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27430
agactttagc cctggtcagc                                                   20


<210> 27431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27431
gccctggtca gccagacaat                                                   20


<210> 27432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27432
ctggtcagcc agacaattgg                                                   20


<210> 27433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27433
cagccagaca attggtggaa                                                   20


<210> 27434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27434
cagacaattg gtggaaaagt                                                   20


<210> 27435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27435
agacaattgg tggaaaagtt                                                   20


<210> 27436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27436
ggaaaagtta ggattccaac                                                   20


<210> 27437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27437
aggattccaa ctggcatttc                                                   20


<210> 27438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27438
caactggcat ttccagatcc                                                   20


<210> 27439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27439
aactggcatt tccagatccc                                                   20


<210> 27440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27440
ggcatttcca gatcccagga                                                   20


<210> 27441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27441
gtgctctttc ctgctccacc                                                   20


<210> 27442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27442
aatctcaaac tgaaaaatat                                                   20


<210> 27443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27443
atctcaaact gaaaaatatc                                                   20


<210> 27444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27444
actgaaaaat atcaggatcc                                                   20


<210> 27445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27445
aaaaatatca ggatcccaga                                                   20


<210> 27446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27446
atatcaggat cccagaaagt                                                   20


<210> 27447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27447
tatcaggatc ccagaaagtg                                                   20


<210> 27448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27448
atcaggatcc cagaaagtga                                                   20


<210> 27449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27449
tcaggatccc agaaagtgag                                                   20


<210> 27450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27450
gatcccagaa agtgaggggt                                                   20


<210> 27451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27451
ggggtaagtg actcatgata                                                   20


<210> 27452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27452
gggtaagtga ctcatgatac                                                   20


<210> 27453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27453
aagtgactca tgatacaggt                                                   20


<210> 27454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27454
catgatacag gtcagcatca                                                   20


<210> 27455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27455
caggtcagca tcacagaaat                                                   20


<210> 27456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27456
ggtcagcatc acagaaataa                                                   20


<210> 27457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27457
gatgctttat gatataacgc                                                   20


<210> 27458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27458
tttatgatat aacgctggtg                                                   20


<210> 27459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27459
tttaaaaata ttaattttaa                                                   20


<210> 27460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27460
taattttaat ggatatctca                                                   20


<210> 27461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27461
aattttaatg gatatctcaa                                                   20


<210> 27462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27462
ctcaaaggct tttcatgaca                                                   20


<210> 27463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27463
tcaaaggctt ttcatgacat                                                   20


<210> 27464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27464
gcttttcatg acataggcca                                                   20


<210> 27465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27465
cttttcatga cataggccac                                                   20


<210> 27466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27466
ataggccaca ggtgttaccc                                                   20


<210> 27467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27467
taggccacag gtgttaccct                                                   20


<210> 27468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27468
ccacaggtgt taccctgggt                                                   20


<210> 27469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27469
acaggtgtta ccctgggtca                                                   20


<210> 27470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27470
ggtgttaccc tgggtcagag                                                   20


<210> 27471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27471
gggtcagagc agttgtccga                                                   20


<210> 27472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27472
tgtccgacag ctctcacatg                                                   20


<210> 27473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27473
taatattgcc aatctctgta                                                   20


<210> 27474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27474
aatctctgta tggtgctcca                                                   20


<210> 27475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27475
tctctgtatg gtgctccaca                                                   20


<210> 27476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27476
ctctgtatgg tgctccacag                                                   20


<210> 27477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27477
tgctccacag aggactacct                                                   20


<210> 27478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27478
agaggactac cttggacctt                                                   20


<210> 27479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27479
atgttcttgt tctatatctt                                                   20


<210> 27480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27480
ttcttgttct atatctttgg                                                   20


<210> 27481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27481
ttctatatct ttggaagttc                                                   20


<210> 27482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27482
tctttggaag ttctggtcct                                                   20


<210> 27483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27483
ttggaagttc tggtcctgag                                                   20


<210> 27484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27484
tggtcctgag aagtttgtct                                                   20


<210> 27485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27485
tctgattaca acaaaaataa                                                   20


<210> 27486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27486
ctgattacaa caaaaataaa                                                   20


<210> 27487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27487
tacaacaaaa ataaaaggac                                                   20


<210> 27488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27488
acaacaaaaa taaaaggaca                                                   20


<210> 27489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27489
caacaaaaat aaaaggacaa                                                   20


<210> 27490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27490
aaaggacaag ggatattttc                                                   20


<210> 27491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27491
aggacaaggg atattttctg                                                   20


<210> 27492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27492
gacaagggat attttctgga                                                   20


<210> 27493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27493
agggatattt tctggagagt                                                   20


<210> 27494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27494
ggatattttc tggagagtaa                                                   20


<210> 27495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27495
catgatctga tattgaaatt                                                   20


<210> 27496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27496
gatctgatat tgaaattcag                                                   20


<210> 27497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27497
atctgatatt gaaattcaga                                                   20


<210> 27498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27498
tctgatattg aaattcagaa                                                   20


<210> 27499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27499
gaaattcaga agggaaatca                                                   20


<210> 27500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27500
attcagaagg gaaatcacag                                                   20


<210> 27501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27501
cagaagggaa atcacagtgg                                                   20


<210> 27502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27502
aatcacagtg gaagtgctct                                                   20


<210> 27503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27503
tgactcctat ttgtgtatga                                                   20


<210> 27504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27504
tgtgtatgat ggttttttca                                                   20


<210> 27505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27505
gtgtatgatg gttttttcaa                                                   20


<210> 27506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27506
tatgatggtt ttttcaaagg                                                   20


<210> 27507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27507
gttttttcaa aggtggttac                                                   20


<210> 27508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27508
taccagttgc attccctgcc                                                   20


<210> 27509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27509
cccagttctg acattgtgac                                                   20


<210> 27510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27510
agttctgaca ttgtgaccag                                                   20


<210> 27511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27511
ttgtgaccag tggcatgcat                                                   20


<210> 27512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27512
gaccagtggc atgcattggt                                                   20


<210> 27513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27513
accagtggca tgcattggtg                                                   20


<210> 27514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27514
ggcatgcatt ggtgaggctg                                                   20


<210> 27515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27515
tgcattggtg aggctgtagc                                                   20


<210> 27516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27516
gcattggtga ggctgtagct                                                   20


<210> 27517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27517
tagctgggtg tgatctgcaa                                                   20


<210> 27518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27518
agctgggtgt gatctgcaat                                                   20


<210> 27519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27519
gggtgtgatc tgcaatggga                                                   20


<210> 27520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27520
gtgtgatctg caatgggaaa                                                   20


<210> 27521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27521
gcaatgggaa agagttaaca                                                   20


<210> 27522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27522
aatgggaaag agttaacaca                                                   20


<210> 27523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27523
gggaaagagt taacacagag                                                   20


<210> 27524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27524
aaagagttaa cacagagcag                                                   20


<210> 27525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27525
aagagttaac acagagcaga                                                   20


<210> 27526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27526
gcatcataac tgaacatatc                                                   20


<210> 27527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27527
catcataact gaacatatcc                                                   20


<210> 27528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27528
ataactgaac atatccaggc                                                   20


<210> 27529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27529
aactgaacat atccaggctg                                                   20


<210> 27530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27530
ccaggctgga gtgttctcac                                                   20


<210> 27531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27531
caggctggag tgttctcact                                                   20


<210> 27532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27532
aggctggagt gttctcacta                                                   20


<210> 27533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27533
ggagtgttct cactagggcc                                                   20


<210> 27534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27534
gagtgttctc actagggccc                                                   20


<210> 27535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27535
agtgttctca ctagggccca                                                   20


<210> 27536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27536
gtgttctcac tagggcccag                                                   20


<210> 27537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27537
cactagggcc caggggcaat                                                   20


<210> 27538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27538
aggggcaatc agctccatac                                                   20


<210> 27539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27539
ggcaatcagc tccatactgg                                                   20


<210> 27540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27540
cttcatcttc attttgtatt                                                   20


<210> 27541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27541
atcttcattt tgtattgagc                                                   20


<210> 27542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27542
ctcatgttga ctctatcact                                                   20


<210> 27543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27543
tcatgttgac tctatcacta                                                   20


<210> 27544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27544
gactctatca ctaaggcctc                                                   20


<210> 27545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27545
ggcctctagt gacactctca                                                   20


<210> 27546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27546
gcctctagtg acactctcat                                                   20


<210> 27547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27547
ctagtgacac tctcatagga                                                   20


<210> 27548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27548
gtgacactct cataggacgg                                                   20


<210> 27549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27549
tgacactctc ataggacggt                                                   20


<210> 27550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27550
ataggacggt gggaatgatg                                                   20


<210> 27551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27551
ggacggtggg aatgatgtgg                                                   20


<210> 27552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27552
cggtgggaat gatgtggcag                                                   20


<210> 27553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27553
tgggaatgat gtggcagaag                                                   20


<210> 27554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27554
tgatgtggca gaagcagttt                                                   20


<210> 27555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27555
gaagcagttt cagatttgtc                                                   20


<210> 27556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27556
aagcagtttc agatttgtct                                                   20


<210> 27557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27557
gcagtttcag atttgtctgg                                                   20


<210> 27558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27558
aatgcaacaa aaccttcatc                                                   20


<210> 27559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27559
atgcaacaaa accttcatct                                                   20


<210> 27560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27560
gcaacaaaac cttcatctgg                                                   20


<210> 27561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27561
accttcatct gggagtgatg                                                   20


<210> 27562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27562
gagtgatgca gcctcctcct                                                   20


<210> 27563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27563
tgcagcctcc tcctcagctc                                                   20


<210> 27564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27564
gcagcctcct cctcagctct                                                   20


<210> 27565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27565
tcctcagctc tgggcacaca                                                   20


<210> 27566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27566
cctcagctct gggcacacat                                                   20


<210> 27567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27567
ctcagctctg ggcacacatg                                                   20


<210> 27568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27568
tctgggcaca catggggtgt                                                   20


<210> 27569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27569
tgggcacaca tggggtgtta                                                   20


<210> 27570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27570
ggcacacatg gggtgttaga                                                   20


<210> 27571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27571
tggggtgtta gagagtgcca                                                   20


<210> 27572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27572
gggtgttaga gagtgccatg                                                   20


<210> 27573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27573
tgttagagag tgccatggag                                                   20


<210> 27574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27574
gagagtgcca tggagcggtg                                                   20


<210> 27575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27575
ccatggagcg gtgcagcaca                                                   20


<210> 27576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27576
ggtgcagcac atagctccga                                                   20


<210> 27577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27577
gtgcagcaca tagctccgat                                                   20


<210> 27578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27578
ccgataggcc ttttgaatga                                                   20


<210> 27579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27579
ataggccttt tgaatgacag                                                   20


<210> 27580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27580
aaatgtcttc ttgcttccat                                                   20


<210> 27581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27581
atgtcttctt gcttccatcg                                                   20


<210> 27582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27582
gtcttcttgc ttccatcgga                                                   20


<210> 27583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27583
ttcttgcttc catcggagag                                                   20


<210> 27584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27584
catcggagag tggttgctat                                                   20


<210> 27585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27585
gagtggttgc tattggttca                                                   20


<210> 27586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27586
agtggttgct attggttcat                                                   20


<210> 27587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27587
ggttcatagg atgattttga                                                   20


<210> 27588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27588
ataggatgat tttgaaagat                                                   20


<210> 27589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27589
ttctcctcca tatttgcctt                                                   20


<210> 27590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27590
ctcctccata tttgccttca                                                   20


<210> 27591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27591
cttcagagaa tccaactccc                                                   20


<210> 27592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27592
tccaactccc cggattctcc                                                   20


<210> 27593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27593
ccaactcccc ggattctcct                                                   20


<210> 27594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27594
ggattctcct aggacattct                                                   20


<210> 27595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27595
tcctaggaca ttcttggtga                                                   20


<210> 27596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27596
acattcttgg tgaaagcaaa                                                   20


<210> 27597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27597
cattcttggt gaaagcaaaa                                                   20


<210> 27598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27598
tgaaagcaaa aaggatgtcc                                                   20


<210> 27599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27599
aagcaaaaag gatgtccaag                                                   20


<210> 27600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27600
caaaaaggat gtccaagcag                                                   20


<210> 27601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27601
caagcagtgg atcttatctc                                                   20


<210> 27602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27602
aagcagtgga tcttatctcc                                                   20


<210> 27603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27603
agcagtggat cttatctcca                                                   20


<210> 27604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27604
gatcttatct ccagggacca                                                   20


<210> 27605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27605
atcttatctc cagggaccaa                                                   20


<210> 27606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27606
ttatctccag ggaccaaagg                                                   20


<210> 27607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27607
tatctccagg gaccaaaggc                                                   20


<210> 27608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27608
ggaccaaagg caggtccatc                                                   20


<210> 27609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27609
aaaggcaggt ccatctggat                                                   20


<210> 27610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27610
ctggatcagt atatttcgat                                                   20


<210> 27611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27611
tggatcagta tatttcgatt                                                   20


<210> 27612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27612
agtatatttc gattgggttt                                                   20


<210> 27613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27613
gtatatttcg attgggtttt                                                   20


<210> 27614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27614
cgattgggtt ttgggattct                                                   20


<210> 27615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27615
gattgggttt tgggattctc                                                   20


<210> 27616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27616
attgggtttt gggattctca                                                   20


<210> 27617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27617
ttgggttttg ggattctcag                                                   20


<210> 27618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27618
ttttgggatt ctcaggggac                                                   20


<210> 27619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27619
ttgggattct caggggacca                                                   20


<210> 27620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27620
gggattctca ggggaccaga                                                   20


<210> 27621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27621
gattctcagg ggaccagaga                                                   20


<210> 27622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27622
gaccagagag agtgtctgca                                                   20


<210> 27623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27623
agagagtgtc tgcaaagtcc                                                   20


<210> 27624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27624
agagtgtctg caaagtccga                                                   20


<210> 27625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27625
agtgtctgca aagtccgaga                                                   20


<210> 27626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27626
gtctgcaaag tccgagagag                                                   20


<210> 27627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27627
caaagtccga gagagcagaa                                                   20


<210> 27628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27628
aaagtccgag agagcagaaa                                                   20


<210> 27629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27629
agcagaaaag gtaataaact                                                   20


<210> 27630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27630
agaaaaggta ataaactgag                                                   20


<210> 27631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27631
gtaataaact gagtggcctc                                                   20


<210> 27632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27632
taataaactg agtggcctct                                                   20


<210> 27633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27633
cctctgggtc aaacttctcc                                                   20


<210> 27634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27634
ctctgggtca aacttctccc                                                   20


<210> 27635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27635
caaacttctc ccaggtctca                                                   20


<210> 27636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27636
aggtctcata gaacatgtca                                                   20


<210> 27637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27637
atgtcaaagt cgtcctcact                                                   20


<210> 27638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27638
tgtcaaagtc gtcctcactc                                                   20


<210> 27639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27639
gtcaaagtcg tcctcactca                                                   20


<210> 27640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27640
tcaaagtcgt cctcactcag                                                   20


<210> 27641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27641
gtcgtcctca ctcaggggct                                                   20


<210> 27642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27642
gggctcagtg ctctcctccg                                                   20


<210> 27643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27643
tctcctccgt ggccacattg                                                   20


<210> 27644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27644
gtggccacat tgaagttctc                                                   20


<210> 27645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27645
atgtacatgt tgaccatgat                                                   20


<210> 27646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27646
tgtacatgtt gaccatgatg                                                   20


<210> 27647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27647
acatgttgac catgatgagg                                                   20


<210> 27648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27648
catgttgacc atgatgagga                                                   20


<210> 27649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27649
tgttgaccat gatgaggaag                                                   20


<210> 27650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27650
tgaggaagga gatgatgatg                                                   20


<210> 27651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27651
gaggaaggag atgatgatgt                                                   20


<210> 27652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27652
gaaggagatg atgatgtagg                                                   20


<210> 27653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27653
agatgatgat gtaggtggtg                                                   20


<210> 27654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27654
tgatgatgta ggtggtgaag                                                   20


<210> 27655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27655
ggtgaagaag atgatgccta                                                   20


<210> 27656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27656
aagaagatga tgcctacggc                                                   20


<210> 27657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27657
agaagatgat gcctacggct                                                   20


<210> 27658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27658
tgcctacggc tgggctccca                                                   20


<210> 27659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27659
tgggctccca cagtcccctc                                                   20


<210> 27660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27660
ccctctggtg ccattgctgt                                                   20


<210> 27661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27661
cctctggtgc cattgctgtt                                                   20


<210> 27662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27662
ctggtgccat tgctgttggg                                                   20


<210> 27663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27663
gccattgctg ttgggcagat                                                   20


<210> 27664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27664
ccattgctgt tgggcagatt                                                   20


<210> 27665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27665
cattgctgtt gggcagattg                                                   20


<210> 27666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27666
tgttgggcag attggggtca                                                   20


<210> 27667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27667
tgggcagatt ggggtcacag                                                   20


<210> 27668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27668
gggcagattg gggtcacagt                                                   20


<210> 27669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27669
ggcagattgg ggtcacagta                                                   20


<210> 27670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27670
gcagattggg gtcacagtag                                                   20


<210> 27671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27671
cagattgggg tcacagtagg                                                   20


<210> 27672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27672
agattggggt cacagtaggg                                                   20


<210> 27673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27673
cagtaggggg gccctgtgtt                                                   20


<210> 27674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27674
agtagggggg ccctgtgttg                                                   20


<210> 27675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27675
ggggggccct gtgttgagga                                                   20


<210> 27676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27676
gggggccctg tgttgaggat                                                   20


<210> 27677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27677
ggggccctgt gttgaggatg                                                   20


<210> 27678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27678
cctgtgttga ggatggggct                                                   20


<210> 27679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27679
ctgtgttgag gatggggctg                                                   20


<210> 27680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27680
gtgttgagga tggggctgag                                                   20


<210> 27681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27681
tgttgaggat ggggctgagg                                                   20


<210> 27682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27682
tggggctgag gaggccatcc                                                   20


<210> 27683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27683
gctgaggagg ccatcccagc                                                   20


<210> 27684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27684
gccatcccag ccggccgacg                                                   20


<210> 27685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27685
agccggccga cgtggtaatc                                                   20


<210> 27686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27686
cggccgacgt ggtaatctgg                                                   20


<210> 27687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27687
gccgacgtgg taatctggaa                                                   20


<210> 27688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27688
ccgacgtggt aatctggaag                                                   20


<210> 27689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27689
gtggtaatct ggaagaggca                                                   20


<210> 27690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27690
gaagaggcac agcatgctgt                                                   20


<210> 27691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27691
ggcacagcat gctgttggcg                                                   20


<210> 27692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27692
gcacagcatg ctgttggcga                                                   20


<210> 27693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27693
gcatgctgtt ggcgaaggtc                                                   20


<210> 27694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27694
tgctgttggc gaaggtctgg                                                   20


<210> 27695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27695
gttgaacatg tcgtcgatgc                                                   20


<210> 27696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27696
tgccagcctc ccacctcaca                                                   20


<210> 27697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27697
gccagcctcc cacctcacat                                                   20


<210> 27698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27698
ccagcctccc acctcacatg                                                   20


<210> 27699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27699
cctcccacct cacatgggga                                                   20


<210> 27700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27700
ccacctcaca tggggaaagc                                                   20


<210> 27701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27701
ggggaaagct ggacataccg                                                   20


<210> 27702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27702
aaagctggac ataccgaaga                                                   20


<210> 27703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27703
agctggacat accgaagata                                                   20


<210> 27704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27704
tggacatacc gaagatagag                                                   20


<210> 27705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27705
atagagtaga tgaacatgac                                                   20


<210> 27706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27706
tagagtagat gaacatgaca                                                   20


<210> 27707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27707
tagatgaaca tgacaaggaa                                                   20


<210> 27708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27708
aacatgacaa ggaatagcaa                                                   20


<210> 27709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27709
atagcaacag cccgatgttg                                                   20


<210> 27710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27710
agcaacagcc cgatgttgaa                                                   20


<210> 27711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27711
gcaacagccc gatgttgaag                                                   20


<210> 27712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27712
caacagcccg atgttgaaga                                                   20


<210> 27713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27713
cagcccgatg ttgaagaggg                                                   20


<210> 27714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27714
agcccgatgt tgaagagggc                                                   20


<210> 27715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27715
ccgatgttga agagggcagg                                                   20


<210> 27716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27716
cgatgttgaa gagggcaggc                                                   20


<210> 27717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27717
gatgttgaag agggcaggca                                                   20


<210> 27718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27718
agggcaggca gggacatcat                                                   20


<210> 27719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27719
gggcaggcag ggacatcatg                                                   20


<210> 27720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27720
ggcaggcagg gacatcatga                                                   20


<210> 27721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27721
gcagggacat catgagggca                                                   20


<210> 27722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27722
agggacatca tgagggcaaa                                                   20


<210> 27723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27723
gacatcatga gggcaaagag                                                   20


<210> 27724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27724
tgagggcaaa gagcagtgtg                                                   20


<210> 27725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27725
gagcagtgtg cggatcccct                                                   20


<210> 27726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27726
tgcggatccc cttggccgct                                                   20


<210> 27727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27727
atccccttgg ccgctcggat                                                   20


<210> 27728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27728
ttggccgctc ggatcagtct                                                   20


<210> 27729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27729
tggccgctcg gatcagtctg                                                   20


<210> 27730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27730
ctcggatcag tctgaggatg                                                   20


<210> 27731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27731
gtctgaggat gcggccaatt                                                   20


<210> 27732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27732
tctgaggatg cggccaattc                                                   20


<210> 27733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27733
aggatgcggc caattcgggc                                                   20


<210> 27734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27734
ggatgcggcc aattcgggcc                                                   20


<210> 27735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27735
tgcggccaat tcgggccagg                                                   20


<210> 27736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27736
gggccaggcg gatgactctg                                                   20


<210> 27737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27737
gccaggcgga tgactctgaa                                                   20


<210> 27738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27738
cggatgactc tgaagagcgt                                                   20


<210> 27739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27739
ggatgactct gaagagcgtt                                                   20


<210> 27740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27740
gatgactctg aagagcgttg                                                   20


<210> 27741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27741
tgactctgaa gagcgttggg                                                   20


<210> 27742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27742
ctctgaagag cgttggggag                                                   20


<210> 27743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27743
gttggggaga agtaactttg                                                   20


<210> 27744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27744
aagtaacttt gaagtgactt                                                   20


<210> 27745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27745
ttgaagtgac ttaagaattg                                                   20


<210> 27746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27746
ttaagaattg cagaaaaaat                                                   20


<210> 27747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27747
taagaattgc agaaaaaatc                                                   20


<210> 27748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27748
agaaaaaatc aggcctttaa                                                   20


<210> 27749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27749
aaaaatcagg cctttaaaag                                                   20


<210> 27750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27750
aaaatcaggc ctttaaaaga                                                   20


<210> 27751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27751
atcaggcctt taaaagaagg                                                   20


<210> 27752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27752
gaaggaagaa attatctaat                                                   20


<210> 27753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27753
aattatctaa ttagtatctc                                                   20


<210> 27754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27754
taattagtat ctccagccat                                                   20


<210> 27755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27755
tccagccatg agacgtgaca                                                   20


<210> 27756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27756
gccatgagac gtgacaaagt                                                   20


<210> 27757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27757
tgatgacact ctgctttgct                                                   20


<210> 27758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27758
acactctgct ttgcttggta                                                   20


<210> 27759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27759
gcttggtata gactgccact                                                   20


<210> 27760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27760
cttggtatag actgccactt                                                   20


<210> 27761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27761
ccacttgggc atccacattt                                                   20


<210> 27762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27762
cacttgggca tccacatttg                                                   20


<210> 27763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27763
gcatccacat ttgaggactc                                                   20


<210> 27764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27764
catccacatt tgaggactct                                                   20


<210> 27765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27765
atttgaggac tctgggccct                                                   20


<210> 27766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27766
ttgaggactc tgggccctca                                                   20


<210> 27767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27767
gactctgggc cctcagagcc                                                   20


<210> 27768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27768
tgggccctca gagcctggca                                                   20


<210> 27769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27769
gccctcagag cctggcatgg                                                   20


<210> 27770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27770
ccctcagagc ctggcatggt                                                   20


<210> 27771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27771
tcagagcctg gcatggtagg                                                   20


<210> 27772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27772
ctggcatggt aggtagcaca                                                   20


<210> 27773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27773
gcatggtagg tagcacaaag                                                   20


<210> 27774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27774
catggtaggt agcacaaagt                                                   20


<210> 27775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27775
atggtaggta gcacaaagta                                                   20


<210> 27776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27776
tggtaggtag cacaaagtag                                                   20


<210> 27777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27777
ggtagcacaa agtaggggct                                                   20


<210> 27778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27778
tcagtaaatg cccattgcat                                                   20


<210> 27779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27779
atgttatctt tgcctccgcc                                                   20


<210> 27780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27780
ctccgcctag aatatcctct                                                   20


<210> 27781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27781
atcctcttgg tcaacctcca                                                   20


<210> 27782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27782
agtcaaaaac ttatcttctg                                                   20


<210> 27783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27783
aaaacttatc ttctgcagcc                                                   20


<210> 27784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27784
ttatcttctg cagccaagtt                                                   20


<210> 27785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27785
cttctgcagc caagttcagc                                                   20


<210> 27786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27786
ctgcagccaa gttcagctgg                                                   20


<210> 27787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27787
agttcagctg gaagtgactg                                                   20


<210> 27788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27788
agtgactgca gtttattcca                                                   20


<210> 27789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27789
gtgactgcag tttattccac                                                   20


<210> 27790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27790
cagtttattc cacaggctca                                                   20


<210> 27791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27791
ttccacaggc tcacagtctt                                                   20


<210> 27792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27792
gcctgttttt tcctatgaca                                                   20


<210> 27793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27793
cctgctcctc cctgatactg                                                   20


<210> 27794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27794
ctccctgata ctgcagcctt                                                   20


<210> 27795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27795
tccctgatac tgcagccttt                                                   20


<210> 27796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27796
tcatgccctt tcctccaccc                                                   20


<210> 27797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27797
ccctggtcct gtgctctgtg                                                   20


<210> 27798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27798
cctggtcctg tgctctgtga                                                   20


<210> 27799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27799
gtcctgtgct ctgtgaaggc                                                   20


<210> 27800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27800
tcctgtgctc tgtgaaggcc                                                   20


<210> 27801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27801
tctccctacc tcctactgtg                                                   20


<210> 27802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27802
gtgaagattg actctgtttc                                                   20


<210> 27803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27803
ttgactctgt ttctggcacc                                                   20


<210> 27804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27804
gtttctggca cccggtcctg                                                   20


<210> 27805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27805
cggtcctgtg gctaattgta                                                   20


<210> 27806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27806
gtcctgtggc taattgtacg                                                   20


<210> 27807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27807
gtggctaatt gtacggagcc                                                   20


<210> 27808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27808
cggagcctgg tgttaattac                                                   20


<210> 27809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27809
ggagcctggt gttaattaca                                                   20


<210> 27810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27810
gagcctggtg ttaattacaa                                                   20


<210> 27811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27811
agcctggtgt taattacaag                                                   20


<210> 27812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27812
gcctggtgtt aattacaagg                                                   20


<210> 27813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27813
tgttaattac aagggggcct                                                   20


<210> 27814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27814
gttaattaca agggggcctg                                                   20


<210> 27815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27815
tacaaggggg cctgaggatt                                                   20


<210> 27816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27816
acaagggggc ctgaggattc                                                   20


<210> 27817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27817
ggcctgagga ttcgggcaac                                                   20


<210> 27818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27818
ggattcgggc aactggctga                                                   20


<210> 27819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27819
gggcaactgg ctgacagcta                                                   20


<210> 27820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27820
ctggctgaca gctaaagcat                                                   20


<210> 27821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27821
tggctgacag ctaaagcata                                                   20


<210> 27822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27822
ggctgacagc taaagcataa                                                   20


<210> 27823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27823
gcataaggga tttgaatgac                                                   20


<210> 27824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27824
tgtttttttt tttttttttt                                                   20


<210> 27825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27825
tttttttttt ttttcggttc                                                   20


<210> 27826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27826
gctgtttttg aactttatgt                                                   20


<210> 27827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27827
ctgtttttga actttatgtt                                                   20


<210> 27828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27828
tgtttttgaa ctttatgtta                                                   20


<210> 27829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27829
ttgaacttta tgttagggcc                                                   20


<210> 27830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27830
gaactttatg ttagggcctg                                                   20


<210> 27831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27831
tttatgttag ggcctggaga                                                   20


<210> 27832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27832
ttatgttagg gcctggagat                                                   20


<210> 27833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27833
ggcctggaga taggtttttt                                                   20


<210> 27834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27834
gcctggagat aggttttttt                                                   20


<210> 27835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27835
cctggagata ggtttttttg                                                   20


<210> 27836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27836
ctggagatag gtttttttgg                                                   20


<210> 27837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27837
ggagataggt ttttttgggg                                                   20


<210> 27838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27838
ataggttttt ttgggggagt                                                   20


<210> 27839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27839
cccaactcca actatgaaca                                                   20


<210> 27840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27840
actccaacta tgaacaaagt                                                   20


<210> 27841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27841
tgaacaaagt tggaaatata                                                   20


<210> 27842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27842
tctatatgat gtctaacttg                                                   20


<210> 27843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27843
acttgaagat gtttgatttt                                                   20


<210> 27844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27844
agatgtttga tttttggtct                                                   20


<210> 27845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27845
gatgtttgat ttttggtctt                                                   20


<210> 27846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27846
atgtttgatt tttggtcttg                                                   20


<210> 27847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27847
gatttttggt cttggggacc                                                   20


<210> 27848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27848
atttttggtc ttggggacct                                                   20


<210> 27849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27849
tttttggtct tggggacctg                                                   20


<210> 27850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27850
tttggtcttg gggacctggg                                                   20


<210> 27851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27851
ggggagcctt atttgtacca                                                   20


<210> 27852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27852
gggagcctta tttgtaccaa                                                   20


<210> 27853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27853
tgtaccaaag gcctccacca                                                   20


<210> 27854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27854
caaaggcctc caccaaagat                                                   20


<210> 27855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27855
aaaggcctcc accaaagatg                                                   20


<210> 27856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27856
gcctccacca aagatgaggc                                                   20


<210> 27857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27857
cctccaccaa agatgaggca                                                   20


<210> 27858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27858
caaagatgag gcaaggcctt                                                   20


<210> 27859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27859
aaagatgagg caaggccttt                                                   20


<210> 27860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27860
atgaggcaag gcctttaggt                                                   20


<210> 27861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27861
gaggcaaggc ctttaggtaa                                                   20


<210> 27862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27862
ggcaaggcct ttaggtaaga                                                   20


<210> 27863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27863
gcaaggcctt taggtaagag                                                   20


<210> 27864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27864
caaggccttt aggtaagaga                                                   20


<210> 27865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27865
agagagggtt caacatctca                                                   20


<210> 27866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27866
gagagggttc aacatctcac                                                   20


<210> 27867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27867
tcaacatctc acaggaaaaa                                                   20


<210> 27868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27868
catctcacag gaaaaatggt                                                   20


<210> 27869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27869
atctcacagg aaaaatggtg                                                   20


<210> 27870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27870
tctcacagga aaaatggtga                                                   20


<210> 27871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27871
aggaaaaatg gtgagggatg                                                   20


<210> 27872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27872
aaaaatggtg agggatgtag                                                   20


<210> 27873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27873
atggtgaggg atgtagcagc                                                   20


<210> 27874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27874
agcaagctct cgctccttgc                                                   20


<210> 27875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27875
gcaagctctc gctccttgcc                                                   20


<210> 27876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27876
tcgctccttg ccaggttccc                                                   20


<210> 27877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27877
cgctccttgc caggttccct                                                   20


<210> 27878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27878
gctctttgtt gttatgcaca                                                   20


<210> 27879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27879
ctctttgttg ttatgcacat                                                   20


<210> 27880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27880
catgggtcac aatattgtgt                                                   20


<210> 27881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27881
ggtcacaata ttgtgttgga                                                   20


<210> 27882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27882
tcacaatatt gtgttggaaa                                                   20


<210> 27883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27883
cacaatattg tgttggaaag                                                   20


<210> 27884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27884
aatattgtgt tggaaagagg                                                   20


<210> 27885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27885
ttgtgttgga aagaggaaga                                                   20


<210> 27886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27886
tgttggaaag aggaagaaag                                                   20


<210> 27887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27887
tggaaagagg aagaaagtag                                                   20


<210> 27888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27888
ggaaagagga agaaagtaga                                                   20


<210> 27889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27889
gaaagaggaa gaaagtagaa                                                   20


<210> 27890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27890
aaagaggaag aaagtagaag                                                   20


<210> 27891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27891
gaagaaagta gaaggggact                                                   20


<210> 27892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27892
aagaaagtag aaggggactt                                                   20


<210> 27893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27893
ttgggaaata attataattt                                                   20


<210> 27894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27894
tttggattat aaaatctttg                                                   20


<210> 27895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27895
ggattataaa atctttgtgg                                                   20


<210> 27896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27896
gaagaccttc tgtgaatttc                                                   20


<210> 27897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27897
ctgtgaattt ccagtttaac                                                   20


<210> 27898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27898
tgtgaatttc cagtttaact                                                   20


<210> 27899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27899
taggacatgt tcccatcgtg                                                   20


<210> 27900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27900
aggacatgtt cccatcgtgt                                                   20


<210> 27901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27901
ggacatgttc ccatcgtgta                                                   20


<210> 27902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27902
cattatttgt ctacatactc                                                   20


<210> 27903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27903
actctggtaa aattttctgc                                                   20


<210> 27904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27904
aaaattttct gccagacaac                                                   20


<210> 27905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27905
tctgccagac aactggtcta                                                   20


<210> 27906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27906
cagcacattt taatttgctc                                                   20


<210> 27907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27907
agcacatttt aatttgctcc                                                   20


<210> 27908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27908
ttgctccagg atcttatttt                                                   20


<210> 27909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27909
tgctccagga tcttatttta                                                   20


<210> 27910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27910
gctccaggat cttattttaa                                                   20


<210> 27911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27911
tccaggatct tattttaagg                                                   20


<210> 27912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27912
gatcttattt taagggagaa                                                   20


<210> 27913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27913
ttcctcgtac ttgtaacaat                                                   20


<210> 27914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27914
gatactcaat cacctcttgt                                                   20


<210> 27915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27915
actcaatcac ctcttgttgg                                                   20


<210> 27916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27916
ctcaatcacc tcttgttggt                                                   20


<210> 27917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27917
atcacctctt gttggtggga                                                   20


<210> 27918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27918
acctcttgtt ggtgggaaag                                                   20


<210> 27919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27919
cttgttggtg ggaaagaaga                                                   20


<210> 27920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27920
ttgttggtgg gaaagaagaa                                                   20


<210> 27921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27921
tgttggtggg aaagaagaaa                                                   20


<210> 27922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27922
ttggtgggaa agaagaaagg                                                   20


<210> 27923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27923
tggtgggaaa gaagaaaggg                                                   20


<210> 27924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27924
gggaaagaag aaagggaggt                                                   20


<210> 27925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27925
ggaaagaaga aagggaggta                                                   20


<210> 27926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27926
aaagaagaaa gggaggtaag                                                   20


<210> 27927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27927
agaagaaagg gaggtaagga                                                   20


<210> 27928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27928
aagaaaggga ggtaaggaga                                                   20


<210> 27929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27929
agaaagggag gtaaggagag                                                   20


<210> 27930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27930
gaaagggagg taaggagaga                                                   20


<210> 27931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27931
agggaggtaa ggagagaggg                                                   20


<210> 27932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27932
aggtaaggag agagggtaga                                                   20


<210> 27933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27933
agggtagaaa gattgatatg                                                   20


<210> 27934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27934
gggtagaaag attgatatgt                                                   20


<210> 27935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27935
ggttttttct gcttattttc                                                   20


<210> 27936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27936
tgcttatttt ccagctctat                                                   20


<210> 27937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27937
gcttattttc cagctctata                                                   20


<210> 27938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27938
cttattttcc agctctataa                                                   20


<210> 27939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27939
tctataaggg attcctgccc                                                   20


<210> 27940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 27940
ataagggatt cctgccccag                                                   20


<210> 27941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27941
gggattcctg ccccagcgga                                                   20


<210> 27942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27942
agcggatggt gctaccctgt                                                   20


<210> 27943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27943
tggtgctacc ctgtaagcca                                                   20


<210> 27944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27944
ggtgctaccc tgtaagccac                                                   20


<210> 27945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27945
accctgtaag ccacaggaac                                                   20


<210> 27946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27946
ctgtaagcca caggaactgg                                                   20


<210> 27947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27947
agccacagga actggtagtt                                                   20


<210> 27948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27948
tagttaagat atccccatca                                                   20


<210> 27949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27949
gatatcccca tcatagaact                                                   20


<210> 27950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27950
ccatcataga actaagtact                                                   20


<210> 27951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27951
tatattactg atacacaaac                                                   20


<210> 27952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27952
tctttaatat aaaatcaaaa                                                   20


<210> 27953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27953
tataaaatca aaatagcctt                                                   20


<210> 27954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27954
gcctttggaa tctttcattt                                                   20


<210> 27955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27955
tttggaatct ttcattttgg                                                   20


<210> 27956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27956
acaaaaactc ctattatgct                                                   20


<210> 27957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27957
aaactcctat tatgctaagt                                                   20


<210> 27958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27958
cctattatgc taagtgagat                                                   20


<210> 27959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27959
ttatgctaag tgagataagc                                                   20


<210> 27960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27960
taagtgagat aagccagaca                                                   20


<210> 27961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27961
gtgagataag ccagacacag                                                   20


<210> 27962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27962
tgagataagc cagacacaga                                                   20


<210> 27963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27963
cgacatgatt gcatttatat                                                   20


<210> 27964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27964
gacatgattg catttatata                                                   20


<210> 27965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27965
tttatataag gaatctaaaa                                                   20


<210> 27966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27966
atctaaaata gtcaaactca                                                   20


<210> 27967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27967
tctaaaatag tcaaactcat                                                   20


<210> 27968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27968
taaaatagtc aaactcatgg                                                   20


<210> 27969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27969
aatagtcaaa ctcatgggag                                                   20


<210> 27970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27970
tagtcaaact catgggagca                                                   20


<210> 27971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27971
aaactcatgg gagcagagaa                                                   20


<210> 27972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27972
catgggagca gagaatagaa                                                   20


<210> 27973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27973
gggagcagag aatagaatgg                                                   20


<210> 27974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27974
gagaatagaa tggtggtttc                                                   20


<210> 27975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27975
agaatagaat ggtggtttcc                                                   20


<210> 27976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27976
aatagaatgg tggtttccag                                                   20


<210> 27977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27977
gaatggtggt ttccaggagc                                                   20


<210> 27978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27978
aatggtggtt tccaggagct                                                   20


<210> 27979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27979
tggtggtttc caggagctgg                                                   20


<210> 27980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27980
ggtggtttcc aggagctggg                                                   20


<210> 27981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27981
tggtttccag gagctgggag                                                   20


<210> 27982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27982
ggtttccagg agctgggagg                                                   20


<210> 27983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27983
gtttccagga gctgggagga                                                   20


<210> 27984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27984
tttccaggag ctgggaggag                                                   20


<210> 27985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 27985
gagctgggag gaggggaaat                                                   20


<210> 27986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27986
agctgggagg aggggaaatt                                                   20


<210> 27987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 27987
gctgggagga ggggaaattg                                                   20


<210> 27988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27988
tgggaggagg ggaaattggg                                                   20


<210> 27989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 27989
gggaggaggg gaaattgggg                                                   20


<210> 27990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27990
aattggggag gtacttgtca                                                   20


<210> 27991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 27991
tgtcaaagtg tacaaacttc                                                   20


<210> 27992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27992
tatgtgacat gaataaatcc                                                   20


<210> 27993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27993
tgtgacatga ataaatccta                                                   20


<210> 27994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27994
aaatcctaga gctctactta                                                   20


<210> 27995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27995
ctagagctct acttatagca                                                   20


<210> 27996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27996
tacttatagc atagtcccta                                                   20


<210> 27997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 27997
tatagcatag tccctatagt                                                   20


<210> 27998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 27998
tgtctaccta aaaatttgcc                                                   20


<210> 27999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 27999
tctacctaaa aatttgccaa                                                   20


<210> 28000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28000
ttgccaagag aataaatctt                                                   20


<210> 28001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28001
gaataaatct taagtgttcc                                                   20


<210> 28002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28002
gcacccaata aataaataaa                                                   20


<210> 28003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28003
cacccaataa ataaataaat                                                   20


<210> 28004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28004
ccaataaata aataaatagg                                                   20


<210> 28005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28005
caataaataa ataaataggc                                                   20


<210> 28006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28006
ataaataaat aaataggcag                                                   20


<210> 28007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28007
taaataaata aataggcagg                                                   20


<210> 28008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28008
aataggcagg aggaaatatt                                                   20


<210> 28009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28009
taggcaggag gaaatatttg                                                   20


<210> 28010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28010
aggcaggagg aaatatttgg                                                   20


<210> 28011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28011
gaggaaatat ttggaggtta                                                   20


<210> 28012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28012
ggaggttatg gacatgtttc                                                   20


<210> 28013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28013
ggacatgttt ctggcattga                                                   20


<210> 28014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28014
catgtttctg gcattgatgg                                                   20


<210> 28015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28015
tctggcattg atggtggtga                                                   20


<210> 28016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28016
tgatggtggt gatggtttca                                                   20


<210> 28017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28017
gatggtggtg atggtttcat                                                   20


<210> 28018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28018
tacttatctc caaactcata                                                   20


<210> 28019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28019
ttgtgtacat taaacatgta                                                   20


<210> 28020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28020
catgtatagc tttttacatg                                                   20


<210> 28021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28021
atgtggatca tacctcaata                                                   20


<210> 28022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28022
ctcaataaag tgttaaaaaa                                                   20


<210> 28023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28023
caataaagtg ttaaaaaaca                                                   20


<210> 28024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28024
taaagtgtta aaaaacagag                                                   20


<210> 28025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28025
cagcaatatc aaaataaaac                                                   20


<210> 28026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 28026
caaaaacaaa ctgaaatccc                                                   20


<210> 28027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28027
cccggaaata cacgcaaccc                                                   20


<210> 28028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28028
ccggaaatac acgcaaccca                                                   20


<210> 28029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28029
cgcaacccaa ggctgtgttt                                                   20


<210> 28030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28030
caaggctgtg tttcagcacc                                                   20


<210> 28031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28031
aaggctgtgt ttcagcacca                                                   20


<210> 28032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28032
gctgtgtttc agcaccaagg                                                   20


<210> 28033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28033
ctgtgtttca gcaccaaggt                                                   20


<210> 28034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28034
tgtgtttcag caccaaggtg                                                   20


<210> 28035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28035
tgtttcagca ccaaggtggg                                                   20


<210> 28036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28036
gtttcagcac caaggtgggg                                                   20


<210> 28037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28037
gaggttgatg aaatgctgtt                                                   20


<210> 28038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28038
aaatgctgtt aagttgtatt                                                   20


<210> 28039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28039
aagttgtatt tagatactct                                                   20


<210> 28040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28040
ctcagctctt gttactaaat                                                   20


<210> 28041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28041
agctcttgtt actaaatcag                                                   20


<210> 28042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28042
tcagtggcaa attaaatcta                                                   20


<210> 28043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28043
cagctacacc ccgacatgaa                                                   20


<210> 28044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28044
tacaccccga catgaaaagt                                                   20


<210> 28045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28045
accccgacat gaaaagtaag                                                   20


<210> 28046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28046
ccccgacatg aaaagtaagc                                                   20


<210> 28047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28047
gacatgaaaa gtaagcaggt                                                   20


<210> 28048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28048
acatgaaaag taagcaggtc                                                   20


<210> 28049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28049
aggtcaggat ataaccaatc                                                   20


<210> 28050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28050
tcaagataca tttataatgc                                                   20


<210> 28051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28051
caagatacat ttataatgcc                                                   20


<210> 28052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28052
tacatttata atgccaggtg                                                   20


<210> 28053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28053
tttataatgc caggtgaagc                                                   20


<210> 28054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28054
taatgccagg tgaagctggt                                                   20


<210> 28055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28055
tgaagctggt gagcatgatt                                                   20


<210> 28056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28056
tgagcatgat ttggccttta                                                   20


<210> 28057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28057
gagcatgatt tggcctttat                                                   20


<210> 28058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28058
agcatgattt ggcctttata                                                   20


<210> 28059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28059
gcctttatag ggtcaaactt                                                   20


<210> 28060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28060
tcaaacttca gctaacccat                                                   20


<210> 28061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28061
cttcagctaa cccataagcc                                                   20


<210> 28062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28062
ttcagctaac ccataagccc                                                   20


<210> 28063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28063
tcagctaacc cataagccca                                                   20


<210> 28064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28064
ctaacccata agcccaggga                                                   20


<210> 28065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28065
taagcccagg gacagtctct                                                   20


<210> 28066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28066
agggacagtc tcttggctgt                                                   20


<210> 28067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28067
agtctcttgg ctgttggtga                                                   20


<210> 28068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28068
gtctcttggc tgttggtgac                                                   20


<210> 28069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28069
tcttggctgt tggtgacagg                                                   20


<210> 28070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28070
ggctgttggt gacaggcagc                                                   20


<210> 28071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28071
gtgacaggca gcaagttcat                                                   20


<210> 28072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28072
acaggcagca agttcattag                                                   20


<210> 28073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28073
cagcaagttc attagaagat                                                   20


<210> 28074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28074
gcaagttcat tagaagattg                                                   20


<210> 28075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28075
attggagcct gttctaaact                                                   20


<210> 28076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28076
ctaaactcag cttcaaccct                                                   20


<210> 28077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28077
gcataatatt cttgatctct                                                   20


<210> 28078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28078
caattttaaa tgtataaaat                                                   20


<210> 28079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28079
aattttaaat gtataaaata                                                   20


<210> 28080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28080
ggataataac acctgcttga                                                   20


<210> 28081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28081
gataataaca cctgcttgac                                                   20


<210> 28082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28082
ataataacac ctgcttgaca                                                   20


<210> 28083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28083
agggctgctg tgaacattca                                                   20


<210> 28084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28084
ggctgctgtg aacattcatg                                                   20


<210> 28085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28085
ctgtgaacat tcatggagcc                                                   20


<210> 28086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28086
aacattcatg gagcccagct                                                   20


<210> 28087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28087
atggagccca gctcagtgct                                                   20


<210> 28088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28088
ccagctcagt gctcagaact                                                   20


<210> 28089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28089
cagctcagtg ctcagaactt                                                   20


<210> 28090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28090
ctcagtgctc agaacttagg                                                   20


<210> 28091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28091
ctcagaactt aggaagtatt                                                   20


<210> 28092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28092
aacttaggaa gtattcagtc                                                   20


<210> 28093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28093
acttaggaag tattcagtca                                                   20


<210> 28094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28094
taggaagtat tcagtcaagg                                                   20


<210> 28095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28095
gcagctccat ttccccatgt                                                   20


<210> 28096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28096
cccatgttag cctctaactc                                                   20


<210> 28097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28097
taattttctc tgaacaccac                                                   20


<210> 28098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28098
caccactgga cccaaaatac                                                   20


<210> 28099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28099
accactggac ccaaaatact                                                   20


<210> 28100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28100
gcctgtcatt caacaacacc                                                   20


<210> 28101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28101
tcattcaaca acacccagac                                                   20


<210> 28102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28102
cattcaacaa cacccagact                                                   20


<210> 28103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28103
acacccagac tgggccttaa                                                   20


<210> 28104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28104
ccttaacagt attaatttct                                                   20


<210> 28105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28105
ctatcactca tgttccctaa                                                   20


<210> 28106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28106
actcatgttc cctaatagaa                                                   20


<210> 28107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28107
tccctaatag aacagttgtg                                                   20


<210> 28108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28108
cctaatagaa cagttgtgta                                                   20


<210> 28109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28109
gttgtgtaga gatttaattc                                                   20


<210> 28110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28110
agagatttaa ttccagaccc                                                   20


<210> 28111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28111
taattccaga ccctagactt                                                   20


<210> 28112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28112
tcctttgaac aatctcctcc                                                   20


<210> 28113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28113
ccagtctttc ctcactttga                                                   20


<210> 28114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28114
tggcaatcca tctccttttc                                                   20


<210> 28115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28115
atccatctcc ttttccagaa                                                   20


<210> 28116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28116
ccttttccag aacagatttt                                                   20


<210> 28117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28117
accacctgcc ccctgctttc                                                   20


<210> 28118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28118
ccctgctttc aagaccataa                                                   20


<210> 28119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28119
gctttcaaga ccataaaagt                                                   20


<210> 28120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28120
ctttcaagac cataaaagta                                                   20


<210> 28121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28121
accataaaag taaggtctgc                                                   20


<210> 28122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28122
cataaaagta aggtctgctg                                                   20


<210> 28123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 28123
ctggagactc catcatctta                                                   20


<210> 28124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28124
actccatcat cttacggtct                                                   20


<210> 28125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28125
ctccatcatc ttacggtctg                                                   20


<210> 28126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28126
atcttacggt ctgaggttct                                                   20


<210> 28127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28127
tcttacggtc tgaggttctc                                                   20


<210> 28128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28128
ttacggtctg aggttctcag                                                   20


<210> 28129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28129
tacggtctga ggttctcagg                                                   20


<210> 28130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28130
cggtctgagg ttctcaggag                                                   20


<210> 28131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28131
gaggagtgat tattccctgt                                                   20


<210> 28132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28132
attattccct gtcagcccct                                                   20


<210> 28133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28133
ttattccctg tcagcccctg                                                   20


<210> 28134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28134
cctgtcagcc cctgaggttc                                                   20


<210> 28135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28135
agcccctgag gttctagcca                                                   20


<210> 28136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28136
gcccctgagg ttctagccat                                                   20


<210> 28137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28137
ctagccatgg gctgtgcaca                                                   20


<210> 28138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28138
gccatgggct gtgcacacag                                                   20


<210> 28139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28139
ccatgggctg tgcacacagt                                                   20


<210> 28140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28140
tgcctgaaaa cacttcgtgt                                                   20


<210> 28141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28141
gaaaacactt cgtgtgagca                                                   20


<210> 28142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28142
aaacacttcg tgtgagcatg                                                   20


<210> 28143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28143
cacttcgtgt gagcatggag                                                   20


<210> 28144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28144
acttcgtgtg agcatggaga                                                   20


<210> 28145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28145
gtgtgagcat ggagaaggcc                                                   20


<210> 28146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28146
gtgagcatgg agaaggccaa                                                   20


<210> 28147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28147
gagaacctct tcatttcact                                                   20


<210> 28148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28148
gaacctcttc atttcactga                                                   20


<210> 28149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28149
acctcttcat ttcactgaga                                                   20


<210> 28150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28150
tcttcatttc actgagagag                                                   20


<210> 28151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28151
tttcactgag agagcagccc                                                   20


<210> 28152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28152
ttcactgaga gagcagccca                                                   20


<210> 28153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28153
catttaaaac ttgctactct                                                   20


<210> 28154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28154
taaaacttgc tactcttgga                                                   20


<210> 28155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28155
ctcttggaaa gctgcaaata                                                   20


<210> 28156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28156
tcttggaaag ctgcaaatac                                                   20


<210> 28157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28157
cttggaaagc tgcaaataca                                                   20


<210> 28158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28158
acataaacac gtatttcaaa                                                   20


<210> 28159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28159
aaacacgtat ttcaaaaagt                                                   20


<210> 28160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28160
acgtatttca aaaagttggt                                                   20


<210> 28161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28161
aagttggttg gttatttcct                                                   20


<210> 28162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28162
gttggttatt tccttggttt                                                   20


<210> 28163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28163
ggttatttcc ttggttttag                                                   20


<210> 28164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28164
ttatttcctt ggttttagaa                                                   20


<210> 28165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28165
ggttttagaa gagcatccca                                                   20


<210> 28166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28166
gcatcccaaa gacccccaaa                                                   20


<210> 28167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28167
atcccaaaga cccccaaaca                                                   20


<210> 28168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28168
tcccaaagac ccccaaacag                                                   20


<210> 28169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28169
caaagacccc caaacagagg                                                   20


<210> 28170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28170
aaagaccccc aaacagaggt                                                   20


<210> 28171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28171
aagaccccca aacagaggtg                                                   20


<210> 28172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28172
ggtggggctt ccccaccacg                                                   20


<210> 28173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28173
ggctgcccac ttactcgcaa                                                   20


<210> 28174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28174
ctgcccactt actcgcaatg                                                   20


<210> 28175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28175
gcccacttac tcgcaatgga                                                   20


<210> 28176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28176
tggagagaac caccacaatg                                                   20


<210> 28177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28177
caatgaagtc aaacacattc                                                   20


<210> 28178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28178
acacattcca gccatttgtg                                                   20


<210> 28179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28179
cattccagcc atttgtgaag                                                   20


<210> 28180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28180
tgtgaagtag tactgcctca                                                   20


<210> 28181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28181
tcatgacaca ttcgcctgtg                                                   20


<210> 28182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 28182
gacacattcg cctgtgaaga                                                   20


<210> 28183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28183
cgcctgtgaa gacggccaca                                                   20


<210> 28184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28184
tgaagacggc cacaaagaac                                                   20


<210> 28185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28185
aagaactggt tgattttgcc                                                   20


<210> 28186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28186
ttttcgtctt ttcttcactt                                                   20


<210> 28187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28187
cttttcttca ctttggtcat                                                   20


<210> 28188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28188
gtcatcagtc tccaccatca                                                   20


<210> 28189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28189
accatcatgg tgatcatgtt                                                   20


<210> 28190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28190
ccatcatggt gatcatgttg                                                   20


<210> 28191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28191
tcatggtgat catgttgagg                                                   20


<210> 28192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28192
gtgatcatgt tgaggcagat                                                   20


<210> 28193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28193
tgatcatgtt gaggcagatg                                                   20


<210> 28194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28194
gaggcagatg aggaccatga                                                   20


<210> 28195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28195
gaccatgatg gtgatgtcaa                                                   20


<210> 28196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28196
ggtgatgtca aaagcttgtc                                                   20


<210> 28197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28197
cttgtctggt cacgatgtca                                                   20


<210> 28198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28198
cgatgtcaaa gacaaaaccc                                                   20


<210> 28199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28199
aaaaccctgg aacttgttct                                                   20


<210> 28200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28200
ggaacttgtt ctgagaaaac                                                   20


<210> 28201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28201
aacttgttct gagaaaacaa                                                   20


<210> 28202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28202
tgttctgaga aaacaagaga                                                   20


<210> 28203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28203
tctgagaaaa caagagatag                                                   20


<210> 28204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28204
aaaacaagag atagtggcat                                                   20


<210> 28205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28205
aaacaagaga tagtggcatc                                                   20


<210> 28206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28206
aacaagagat agtggcatca                                                   20


<210> 28207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28207
gatagtggca tcagggcctt                                                   20


<210> 28208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28208
atagtggcat cagggccttt                                                   20


<210> 28209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28209
tggcatcagg gcctttgggc                                                   20


<210> 28210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28210
gcctttgggc cagcacaaac                                                   20


<210> 28211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28211
cctttgggcc agcacaaacc                                                   20


<210> 28212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28212
ccaggcatct gtgttatctg                                                   20


<210> 28213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28213
catctgtgtt atctgtagat                                                   20


<210> 28214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28214
catcacactc cacatcttaa                                                   20


<210> 28215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28215
cacactccac atcttaacag                                                   20


<210> 28216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28216
ctcttccaaa atttcacttt                                                   20


<210> 28217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28217
ttgactctac ctcattgccc                                                   20


<210> 28218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28218
ctacctcatt gccccagttc                                                   20


<210> 28219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28219
caagtcctta atacctctcc                                                   20


<210> 28220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28220
tcctggccct ttgatgccac                                                   20


<210> 28221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28221
cctggccctt tgatgccacc                                                   20


<210> 28222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28222
accaggccct tcttttgtcc                                                   20


<210> 28223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28223
tgccctccta tctcctctct                                                   20


<210> 28224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28224
cttggctgtc taaattccaa                                                   20


<210> 28225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28225
gtctaaattc caacagtctt                                                   20


<210> 28226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28226
ttgagtaatc catctctttt                                                   20


<210> 28227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28227
tttaagctcc acttactgca                                                   20


<210> 28228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28228
taagctccac ttactgcatg                                                   20


<210> 28229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28229
ttactgcatg gagtgtccct                                                   20


<210> 28230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28230
aacacactac cctgtccctt                                                   20


<210> 28231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28231
acacactacc ctgtcccttt                                                   20


<210> 28232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28232
cacactaccc tgtccctttg                                                   20


<210> 28233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28233
cctttgggga tcccactttt                                                   20


<210> 28234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28234
tggggatccc acttttcagt                                                   20


<210> 28235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28235
cccacttttc agtcagcctc                                                   20


<210> 28236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28236
tttcagtcag cctcgagttc                                                   20


<210> 28237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28237
tgtatatgcg tcttctctac                                                   20


<210> 28238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28238
cgtcttctct actagacaat                                                   20


<210> 28239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28239
tactagacaa tgagctgttt                                                   20


<210> 28240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28240
actagacaat gagctgtttg                                                   20


<210> 28241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28241
acaatgagct gtttgaggac                                                   20


<210> 28242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28242
caatgagctg tttgaggaca                                                   20


<210> 28243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28243
aatgagctgt ttgaggacaa                                                   20


<210> 28244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28244
tccttaactt tgtttccctg                                                   20


<210> 28245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28245
tgcagtgccc tgcacattgc                                                   20


<210> 28246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28246
cagtgccctg cacattgcaa                                                   20


<210> 28247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28247
cctgcacatt gcaagagttc                                                   20


<210> 28248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28248
tgcacattgc aagagttcaa                                                   20


<210> 28249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28249
gctgcttgaa atattaattt                                                   20


<210> 28250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28250
ttaatttgag ctactttgct                                                   20


<210> 28251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28251
aatttgagct actttgctga                                                   20


<210> 28252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28252
gagctacttt gctgagagta                                                   20


<210> 28253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28253
actttgctga gagtaaagtc                                                   20


<210> 28254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28254
tgagagtaaa gtcaagtgca                                                   20


<210> 28255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28255
gagagtaaag tcaagtgcaa                                                   20


<210> 28256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28256
agagtaaagt caagtgcaaa                                                   20


<210> 28257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28257
gagtaaagtc aagtgcaaag                                                   20


<210> 28258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28258
gcaaagggga aacttattct                                                   20


<210> 28259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28259
ggaaatgttc cctctgttcc                                                   20


<210> 28260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28260
ctggtgctgt gcaaatgcct                                                   20


<210> 28261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28261
tgcaaatgcc taagcaaatg                                                   20


<210> 28262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28262
gcaaatgcct aagcaaatgc                                                   20


<210> 28263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28263
tgcctaagca aatgcaggta                                                   20


<210> 28264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28264
gcctaagcaa atgcaggtat                                                   20


<210> 28265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28265
cctaagcaaa tgcaggtata                                                   20


<210> 28266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28266
gcaaatgcag gtatagggcg                                                   20


<210> 28267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28267
caaatgcagg tatagggcgt                                                   20


<210> 28268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28268
aaatgcaggt atagggcgta                                                   20


<210> 28269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28269
caggtatagg gcgtagggtc                                                   20


<210> 28270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28270
tagggcgtag ggtcaagtct                                                   20


<210> 28271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28271
agtcttggtt gtttgcatct                                                   20


<210> 28272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28272
cttggttgtt tgcatcttgg                                                   20


<210> 28273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28273
ttggttgttt gcatcttgga                                                   20


<210> 28274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28274
ggttgtttgc atcttggaag                                                   20


<210> 28275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28275
gttgtttgca tcttggaagg                                                   20


<210> 28276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28276
gtttgcatct tggaaggagg                                                   20


<210> 28277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28277
ttgcatcttg gaaggaggca                                                   20


<210> 28278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28278
catcttggaa ggaggcagag                                                   20


<210> 28279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28279
tggaaggagg cagagtggcc                                                   20


<210> 28280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28280
gcagagtggc ctggataacc                                                   20


<210> 28281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28281
agagtggcct ggataaccaa                                                   20


<210> 28282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28282
accaagagat catttatatc                                                   20


<210> 28283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28283
tttatatctg gttattttta                                                   20


<210> 28284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28284
atttttatgg tgtctttaaa                                                   20


<210> 28285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28285
actgtgatct tctcttcttt                                                   20


<210> 28286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28286
tgaacatctt actgctctgt                                                   20


<210> 28287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28287
aaaacttctc ctgacctcta                                                   20


<210> 28288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28288
aacttctcct gacctctatg                                                   20


<210> 28289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28289
cacatatctc cccctattca                                                   20


<210> 28290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28290
acatatctcc ccctattcaa                                                   20


<210> 28291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28291
ctcccctacc ccatgtacct                                                   20


<210> 28292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28292
tcccctaccc catgtacctc                                                   20


<210> 28293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28293
cccctacccc atgtacctca                                                   20


<210> 28294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28294
ccctacccca tgtacctcag                                                   20


<210> 28295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28295
accccatgta cctcaggggt                                                   20


<210> 28296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28296
ccccatgtac ctcaggggtt                                                   20


<210> 28297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28297
tgtacctcag gggttaggcc                                                   20


<210> 28298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28298
taaaacccct tcttgctttg                                                   20


<210> 28299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28299
tgctttgaag ctttgccacc                                                   20


<210> 28300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28300
actgccgctt gccaaactct                                                   20


<210> 28301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28301
aactcttggt ccctctgcct                                                   20


<210> 28302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28302
tccctctgcc tcagtaatga                                                   20


<210> 28303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28303
ccctctgcct cagtaatgat                                                   20


<210> 28304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28304
ctgcctcagt aatgatgggt                                                   20


<210> 28305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28305
tgcctcagta atgatgggtg                                                   20


<210> 28306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28306
gtaatgatgg gtgaggctct                                                   20


<210> 28307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28307
tggccatatt tgcccactct                                                   20


<210> 28308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28308
cccactcttg gctattatcc                                                   20


<210> 28309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28309
ccactcttgg ctattatcct                                                   20


<210> 28310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28310
gtgcattact ctttgtctct                                                   20


<210> 28311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28311
tgcacaaatc tctaatgacc                                                   20


<210> 28312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28312
acctagtttc tcctaactta                                                   20


<210> 28313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28313
tagtttctcc taacttaaag                                                   20


<210> 28314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28314
taacttaaag cagaatattt                                                   20


<210> 28315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28315
cagaaactta catctccctc                                                   20


<210> 28316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28316
tctccctcca gctaccatct                                                   20


<210> 28317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28317
tagatctctt cccaccttca                                                   20


<210> 28318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28318
ttcaaagcaa aatttcttga                                                   20


<210> 28319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28319
caaagcaaaa tttcttgaaa                                                   20


<210> 28320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28320
ttgaaagagt tgtgtacaat                                                   20


<210> 28321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28321
agtgtccctc attcactcct                                                   20


<210> 28322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28322
cactcctcag cccacatcaa                                                   20


<210> 28323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28323
ctcctcagcc cacatcaaca                                                   20


<210> 28324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28324
agcttttgcc tctatcctga                                                   20


<210> 28325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28325
cttttgcctc tatcctgaca                                                   20


<210> 28326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28326
tgacagagat tgttctcact                                                   20


<210> 28327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28327
tgaatgactt cccataatat                                                   20


<210> 28328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28328
cttcccataa tattagatcc                                                   20


<210> 28329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28329
ttcccataat attagatcca                                                   20


<210> 28330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28330
gacgcttgtc tgatattgcc                                                   20


<210> 28331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28331
accttgaaat gttgctttct                                                   20


<210> 28332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28332
ccatttgtga tgctctttta                                                   20


<210> 28333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28333
agtctccttt acccaacttt                                                   20


<210> 28334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28334
tttacccaac ttttagacat                                                   20


<210> 28335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28335
tacccaactt ttagacatca                                                   20


<210> 28336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28336
tttagacatc agagttcttc                                                   20


<210> 28337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28337
ttagacatca gagttcttcg                                                   20


<210> 28338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28338
catcagagtt cttcgaggct                                                   20


<210> 28339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28339
gttcttcgag gctcagtctt                                                   20


<210> 28340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28340
ttctcccttg acaatttatc                                                   20


<210> 28341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28341
cccttgacaa tttatccagc                                                   20


<210> 28342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28342
ccttgacaat ttatccagcc                                                   20


<210> 28343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28343
taacatatat gtgcaacttt                                                   20


<210> 28344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28344
caactgtttg cctctgtcac                                                   20


<210> 28345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28345
gtcactggac tgtaaactgt                                                   20


<210> 28346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28346
cactggactg taaactgtaa                                                   20


<210> 28347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28347
tggactgtaa actgtaagag                                                   20


<210> 28348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28348
ggactgtaaa ctgtaagagt                                                   20


<210> 28349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28349
cttgctcact gctctaaccc                                                   20


<210> 28350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28350
ctctaaccct ggtgtctgca                                                   20


<210> 28351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28351
cctggtgtct gcatagtgcc                                                   20


<210> 28352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28352
tgcatagtgc ctggctgcaa                                                   20


<210> 28353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28353
tctgcaaatt tgtaaatgaa                                                   20


<210> 28354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28354
gcaaatttgt aaatgaatgg                                                   20


<210> 28355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28355
atttgtaaat gaatggaaga                                                   20


<210> 28356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28356
taaatgaatg gaagacagaa                                                   20


<210> 28357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28357
aaatgaatgg aagacagaat                                                   20


<210> 28358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28358
tgaatggaag acagaatggg                                                   20


<210> 28359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28359
aagacagaat gggcagctct                                                   20


<210> 28360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28360
gggcagctct gagttaacca                                                   20


<210> 28361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28361
atagctcaaa tgaaaattta                                                   20


<210> 28362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28362
actaaattca attctgtacc                                                   20


<210> 28363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28363
ctaaattcaa ttctgtacca                                                   20


<210> 28364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28364
taaattcaat tctgtaccaa                                                   20


<210> 28365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28365
aagggtacat actgaatgta                                                   20


<210> 28366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28366
agggtacata ctgaatgtat                                                   20


<210> 28367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28367
actgaatgta tgggatgtgc                                                   20


<210> 28368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28368
ggatgtgcaa gcctctgcat                                                   20


<210> 28369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28369
tgtgcaagcc tctgcatgag                                                   20


<210> 28370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28370
gcctctgcat gagtggctat                                                   20


<210> 28371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28371
cctctgcatg agtggctatg                                                   20


<210> 28372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28372
ctctgcatga gtggctatga                                                   20


<210> 28373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28373
ctgcatgagt ggctatgagg                                                   20


<210> 28374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28374
tgcatgagtg gctatgaggg                                                   20


<210> 28375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28375
atgagtggct atgagggagg                                                   20


<210> 28376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28376
gagtggctat gagggaggaa                                                   20


<210> 28377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28377
tggctatgag ggaggaagag                                                   20


<210> 28378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28378
agaacctgtc tgatcccttc                                                   20


<210> 28379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28379
gaacctgtct gatcccttcc                                                   20


<210> 28380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28380
aacctgtctg atcccttcca                                                   20


<210> 28381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28381
cctgtctgat cccttccagg                                                   20


<210> 28382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 28382
gatcccttcc agggagccca                                                   20


<210> 28383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28383
atcccttcca gggagcccac                                                   20


<210> 28384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28384
cccttccagg gagcccacgg                                                   20


<210> 28385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28385
gggagcccac gggagctgca                                                   20


<210> 28386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28386
gcccacggga gctgcacagc                                                   20


<210> 28387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28387
cacgggagct gcacagcaag                                                   20


<210> 28388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28388
cgggagctgc acagcaagca                                                   20


<210> 28389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28389
gggagctgca cagcaagcag                                                   20


<210> 28390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28390
ggagctgcac agcaagcaga                                                   20


<210> 28391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28391
gagctgcaca gcaagcagag                                                   20


<210> 28392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28392
agctgcacag caagcagagg                                                   20


<210> 28393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28393
tgcacagcaa gcagaggggg                                                   20


<210> 28394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28394
agagggggaa gtgctgtgat                                                   20


<210> 28395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28395
gagggggaag tgctgtgatg                                                   20


<210> 28396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28396
gatccttgcc ttctgcttca                                                   20


<210> 28397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28397
ccttgccttc tgcttcatgg                                                   20


<210> 28398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28398
cttgccttct gcttcatggt                                                   20


<210> 28399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28399
ttgccttctg cttcatggtg                                                   20


<210> 28400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28400
cttctgcttc atggtgggga                                                   20


<210> 28401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28401
ttctgcttca tggtggggat                                                   20


<210> 28402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28402
gggatgggtt gctatcctgt                                                   20


<210> 28403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28403
ggatgggttg ctatcctgtt                                                   20


<210> 28404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28404
gggttgctat cctgttgggt                                                   20


<210> 28405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28405
gttgctatcc tgttgggtta                                                   20


<210> 28406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28406
tatcctgttg ggttagagca                                                   20


<210> 28407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28407
gttgggttag agcaaagaat                                                   20


<210> 28408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28408
tagagcaaag aatcagacca                                                   20


<210> 28409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28409
agcaaagaat cagaccaaag                                                   20


<210> 28410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28410
accaaagtgg cctttgctca                                                   20


<210> 28411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28411
aaagtggcct ttgctcatgg                                                   20


<210> 28412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28412
tttgctcatg gcagaactgc                                                   20


<210> 28413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28413
ctgctggctc acatctttcc                                                   20


<210> 28414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28414
tgctggctca catctttcct                                                   20


<210> 28415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28415
gctggctcac atctttcctg                                                   20


<210> 28416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28416
ggctcacatc tttcctgggg                                                   20


<210> 28417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28417
gctcacatct ttcctggggc                                                   20


<210> 28418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28418
tcacatcttt cctggggcag                                                   20


<210> 28419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28419
cacatctttc ctggggcagg                                                   20


<210> 28420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28420
acatctttcc tggggcagga                                                   20


<210> 28421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28421
catctttcct ggggcaggag                                                   20


<210> 28422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28422
atctttcctg gggcaggagg                                                   20


<210> 28423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28423
ggggcaggag ggggattgct                                                   20


<210> 28424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28424
ttccatttca tcactgaaaa                                                   20


<210> 28425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28425
ctgaaaatgg tgaaaaaata                                                   20


<210> 28426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28426
tgaaaatggt gaaaaaatac                                                   20


<210> 28427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28427
aaaaaataca ggcccattca                                                   20


<210> 28428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28428
tcacatgact tctaattaaa                                                   20


<210> 28429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28429
acatgacttc taattaaaca                                                   20


<210> 28430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28430
tgacttctaa ttaaacagag                                                   20


<210> 28431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28431
gacttctaat taaacagagc                                                   20


<210> 28432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 28432
taattaaaca gagcaggcaa                                                   20


<210> 28433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28433
gagcaggcaa cggcatcgtt                                                   20


<210> 28434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28434
caggcaacgg catcgttaag                                                   20


<210> 28435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28435
caacggcatc gttaagtggc                                                   20


<210> 28436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28436
aacggcatcg ttaagtggct                                                   20


<210> 28437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28437
tcgttaagtg gctgggtgtg                                                   20


<210> 28438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28438
gctgggtgtg aagtttgccc                                                   20


<210> 28439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28439
tgccctggat attctgactt                                                   20


<210> 28440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28440
gccctggata ttctgacttt                                                   20


<210> 28441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28441
ccctggatat tctgacttta                                                   20


<210> 28442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28442
gatattctga ctttagggaa                                                   20


<210> 28443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28443
tattctgact ttagggaatg                                                   20


<210> 28444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28444
tctgacttta gggaatggag                                                   20


<210> 28445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28445
tagggaatgg agtagcttgc                                                   20


<210> 28446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28446
agtagcttgc tagctgctct                                                   20


<210> 28447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28447
cttgctagct gctcttggat                                                   20


<210> 28448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 28448
gctgctcttg gattagccca                                                   20


<210> 28449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28449
ctcttggatt agcccacggt                                                   20


<210> 28450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28450
tcttggatta gcccacggtc                                                   20


<210> 28451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28451
cttggattag cccacggtca                                                   20


<210> 28452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28452
gatcatacct ttgcaaccct                                                   20


<210> 28453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28453
tttgcaaccc ttggtgctct                                                   20


<210> 28454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28454
tgcaaccctt ggtgctctca                                                   20


<210> 28455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28455
tggtgctctc agagacgatg                                                   20


<210> 28456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28456
tgctctcaga gacgatgaag                                                   20


<210> 28457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28457
gctctcagag acgatgaagt                                                   20


<210> 28458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28458
attgattatg tgatattctc                                                   20


<210> 28459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28459
tgattatgtg atattctcta                                                   20


<210> 28460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28460
gagcctatta tatttctata                                                   20


<210> 28461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28461
cctattatat ttctataaag                                                   20


<210> 28462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28462
tattatattt ctataaagtg                                                   20


<210> 28463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28463
ttctataaag tggagtatgt                                                   20


<210> 28464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28464
ctataaagtg gagtatgtga                                                   20


<210> 28465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28465
gctgctttta ttgatttctg                                                   20


<210> 28466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28466
gcttttattg atttctgtag                                                   20


<210> 28467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28467
cttttattga tttctgtagc                                                   20


<210> 28468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28468
ttttattgat ttctgtagca                                                   20


<210> 28469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28469
ttctgtagca gggaatgtta                                                   20


<210> 28470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28470
tgttaaagaa taaaatttcc                                                   20


<210> 28471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28471
aataaaattt cccagtcttg                                                   20


<210> 28472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28472
ggaatcctta acttttccta                                                   20


<210> 28473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28473
atccttaact tttcctatgg                                                   20


<210> 28474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28474
acttttccta tggaagaaac                                                   20


<210> 28475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28475
cctatggaag aaacaagatt                                                   20


<210> 28476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28476
tatggaagaa acaagattta                                                   20


<210> 28477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28477
agaaacaaga tttagagcct                                                   20


<210> 28478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28478
atttagagcc tgagcatcat                                                   20


<210> 28479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28479
ttagagcctg agcatcatca                                                   20


<210> 28480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28480
tagagcctga gcatcatcag                                                   20


<210> 28481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28481
gcctgagcat catcagaggt                                                   20


<210> 28482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28482
ctgagcatca tcagaggtga                                                   20


<210> 28483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28483
tgagcatcat cagaggtgag                                                   20


<210> 28484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28484
agcatcatca gaggtgagag                                                   20


<210> 28485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28485
gcatcatcag aggtgagagg                                                   20


<210> 28486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28486
agaggtgaga ggaggtgtgt                                                   20


<210> 28487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28487
gaggtgagag gaggtgtgtg                                                   20


<210> 28488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28488
aggtgtgtga ggctcctatg                                                   20


<210> 28489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28489
gtgaggctcc tatgtggtcc                                                   20


<210> 28490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28490
tgaggctcct atgtggtccc                                                   20


<210> 28491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28491
gctcctatgt ggtcccaggt                                                   20


<210> 28492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28492
aggtaagctc tgtcatgaaa                                                   20


<210> 28493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28493
aaatggcacc catgcactga                                                   20


<210> 28494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28494
aatggcaccc atgcactgat                                                   20


<210> 28495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28495
atggcaccca tgcactgatg                                                   20


<210> 28496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28496
gcacccatgc actgatgggg                                                   20


<210> 28497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28497
atggggcaga aatcctgtgt                                                   20


<210> 28498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28498
atcctgtgtc agtgctttgc                                                   20


<210> 28499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28499
cagtgctttg ctggtatgac                                                   20


<210> 28500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28500
ggtatgacca gcttgacctt                                                   20


<210> 28501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28501
gtatgaccag cttgaccttt                                                   20


<210> 28502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28502
tatgaccagc ttgacctttg                                                   20


<210> 28503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28503
gcttgacctt tggggctcct                                                   20


<210> 28504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28504
cttgaccttt ggggctccta                                                   20


<210> 28505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28505
ttgacctttg gggctcctaa                                                   20


<210> 28506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28506
tgacctttgg ggctcctaag                                                   20


<210> 28507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28507
acctttgggg ctcctaaggg                                                   20


<210> 28508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28508
tttggggctc ctaaggggag                                                   20


<210> 28509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28509
ttggggctcc taaggggaga                                                   20


<210> 28510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28510
gggctcctaa ggggagaagg                                                   20


<210> 28511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28511
aggggagaag gtggacattc                                                   20


<210> 28512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28512
ggggagaagg tggacattcc                                                   20


<210> 28513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28513
gggagaaggt ggacattcca                                                   20


<210> 28514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28514
acattccagg gccaataatc                                                   20


<210> 28515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28515
agggccaata atctggccaa                                                   20


<210> 28516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28516
ccaataatct ggccaaaagc                                                   20


<210> 28517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28517
taatctggcc aaaagcaagc                                                   20


<210> 28518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28518
aatctggcca aaagcaagct                                                   20


<210> 28519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28519
ggccaaaagc aagctgggcc                                                   20


<210> 28520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28520
gccaaaagca agctgggcct                                                   20


<210> 28521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28521
aaaagcaagc tgggcctggg                                                   20


<210> 28522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28522
agcaagctgg gcctgggaag                                                   20


<210> 28523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28523
gcaagctggg cctgggaaga                                                   20


<210> 28524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28524
caagctgggc ctgggaagaa                                                   20


<210> 28525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28525
gggcctggga agaagggtct                                                   20


<210> 28526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28526
ctgggaagaa gggtcttagt                                                   20


<210> 28527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28527
tgggaagaag ggtcttagtt                                                   20


<210> 28528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28528
ggaagaaggg tcttagttgg                                                   20


<210> 28529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28529
agaagggtct tagttgggag                                                   20


<210> 28530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28530
gaagggtctt agttgggagt                                                   20


<210> 28531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28531
gtgggaattt ccttttgcct                                                   20


<210> 28532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28532
tttgccttgg atttctttct                                                   20


<210> 28533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28533
ttggatttct ttcttggttc                                                   20


<210> 28534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28534
tttcttggtt ctagactttg                                                   20


<210> 28535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28535
tcttggttct agactttgaa                                                   20


<210> 28536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28536
cttggttcta gactttgaag                                                   20


<210> 28537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28537
ttggttctag actttgaaga                                                   20


<210> 28538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28538
gttctagact ttgaagaggg                                                   20


<210> 28539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 28539
tttgaagagg gaagatgatc                                                   20


<210> 28540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28540
gatgatccgg cttgtgccac                                                   20


<210> 28541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28541
atgatccggc ttgtgccact                                                   20


<210> 28542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28542
ggcttgtgcc actgggcatg                                                   20


<210> 28543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28543
gcttgtgcca ctgggcatgt                                                   20


<210> 28544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28544
cactgggcat gtgggtgtca                                                   20


<210> 28545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28545
caaagatgtt gcctgccatt                                                   20


<210> 28546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28546
gttgcctgcc atttggatgc                                                   20


<210> 28547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28547
cctgccattt ggatgctggt                                                   20


<210> 28548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28548
ctgccatttg gatgctggtc                                                   20


<210> 28549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28549
gccatttgga tgctggtcag                                                   20


<210> 28550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28550
tttggatgct ggtcaggagc                                                   20


<210> 28551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28551
ttggatgctg gtcaggagct                                                   20


<210> 28552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28552
atgctggtca ggagctagga                                                   20


<210> 28553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28553
gtcaggagct aggatggtcc                                                   20


<210> 28554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28554
ctaggatggt ccaagaccta                                                   20


<210> 28555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28555
taggatggtc caagacctat                                                   20


<210> 28556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28556
ggtccaagac ctatgggtcc                                                   20


<210> 28557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28557
tccaagacct atgggtcctg                                                   20


<210> 28558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28558
gacctatggg tcctggagtg                                                   20


<210> 28559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28559
tcctggagtg cagccatctg                                                   20


<210> 28560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28560
cctggagtgc agccatctgc                                                   20


<210> 28561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28561
agccatctgc aggtgctgct                                                   20


<210> 28562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28562
ctttgtgctg atttctctgt                                                   20


<210> 28563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28563
ttggcatccc tgccacttca                                                   20


<210> 28564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28564
aaagttttgt ttaaatgttc                                                   20


<210> 28565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28565
taaatgttct agccttgcct                                                   20


<210> 28566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28566
ttgcctcagc tatgcgaaat                                                   20


<210> 28567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28567
tgcctcagct atgcgaaatt                                                   20


<210> 28568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28568
gcctcagcta tgcgaaatta                                                   20


<210> 28569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28569
ctatgcgaaa ttagggaaca                                                   20


<210> 28570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28570
tatgcgaaat tagggaacaa                                                   20


<210> 28571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28571
cgaaattagg gaacaaagga                                                   20


<210> 28572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28572
aaattaggga acaaaggaaa                                                   20


<210> 28573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28573
gaaagagtgt ttaccttgct                                                   20


<210> 28574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28574
aaagagtgtt taccttgctt                                                   20


<210> 28575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28575
agtgtttacc ttgcttgggc                                                   20


<210> 28576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28576
cttgcttggg ccagaatatt                                                   20


<210> 28577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28577
ttgcttgggc cagaatatta                                                   20


<210> 28578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28578
tgcttgggcc agaatattaa                                                   20


<210> 28579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28579
gcttgggcca gaatattaag                                                   20


<210> 28580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28580
ttgggccaga atattaaggg                                                   20


<210> 28581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28581
gggccagaat attaagggga                                                   20


<210> 28582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28582
gagagccacg ttcctccact                                                   20


<210> 28583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28583
agagccacgt tcctccacta                                                   20


<210> 28584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28584
ccacgttcct ccactaaggc                                                   20


<210> 28585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28585
tcctccacta aggctagcaa                                                   20


<210> 28586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28586
cctccactaa ggctagcaaa                                                   20


<210> 28587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28587
actaaggcta gcaaaaggtt                                                   20


<210> 28588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28588
taaggctagc aaaaggttga                                                   20


<210> 28589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28589
atccactctt cttccattca                                                   20


<210> 28590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28590
tccactcttc ttccattcaa                                                   20


<210> 28591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28591
ctcttcttcc attcaaagga                                                   20


<210> 28592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28592
cttcttccat tcaaaggatg                                                   20


<210> 28593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28593
attcaaagga tggagaatct                                                   20


<210> 28594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28594
ttcaaaggat ggagaatctc                                                   20


<210> 28595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28595
aggatggaga atctcaggaa                                                   20


<210> 28596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28596
gagaatctca ggaacagaat                                                   20


<210> 28597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28597
tcaggaacag aattggttat                                                   20


<210> 28598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28598
caggaacaga attggttatg                                                   20


<210> 28599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28599
tttcacttcc cctccacatg                                                   20


<210> 28600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28600
tcacttcccc tccacatgtg                                                   20


<210> 28601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28601
cacttcccct ccacatgtgg                                                   20


<210> 28602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 28602
gtctccccct gtgccatcct                                                   20


<210> 28603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28603
ctccccctgt gccatcctcg                                                   20


<210> 28604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28604
tccccctgtg ccatcctcgg                                                   20


<210> 28605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28605
gtgccatcct cggaggatct                                                   20


<210> 28606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28606
tcctcggagg atcttagttg                                                   20


<210> 28607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28607
gatcttagtt gcagcttaat                                                   20


<210> 28608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28608
atcttagttg cagcttaatt                                                   20


<210> 28609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28609
cttagttgca gcttaattag                                                   20


<210> 28610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28610
tgcagcttaa ttaggagaaa                                                   20


<210> 28611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28611
gagaaatggt gattttgttg                                                   20


<210> 28612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28612
agaaatggtg attttgttgc                                                   20


<210> 28613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28613
tcccactcct atttactgcc                                                   20


<210> 28614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28614
actgcctgga atttcaacat                                                   20


<210> 28615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28615
ctgcctggaa tttcaacatt                                                   20


<210> 28616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28616
tgcctggaat ttcaacatta                                                   20


<210> 28617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28617
acattagggt catgcctttg                                                   20


<210> 28618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28618
cattagggtc atgcctttgt                                                   20


<210> 28619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28619
tagggtcatg cctttgtagg                                                   20


<210> 28620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28620
ttgtaggtag atgccctctc                                                   20


<210> 28621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28621
tgtaggtaga tgccctctcc                                                   20


<210> 28622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28622
gtaggtagat gccctctcca                                                   20


<210> 28623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28623
aatatgattt atcttgtcct                                                   20


<210> 28624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28624
ctaagaatgt tgtcttcctt                                                   20


<210> 28625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28625
taagaatgtt gtcttccttg                                                   20


<210> 28626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28626
aagaatgttg tcttccttga                                                   20


<210> 28627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28627
agaatgttgt cttccttgag                                                   20


<210> 28628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28628
aatgttgtct tccttgaggg                                                   20


<210> 28629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28629
atgttgtctt ccttgagggg                                                   20


<210> 28630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28630
ttgtcttcct tgaggggagg                                                   20


<210> 28631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28631
tgaggggagg aagctttctt                                                   20


<210> 28632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28632
ggggaggaag ctttctttgg                                                   20


<210> 28633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28633
aagctttctt tggcagccta                                                   20


<210> 28634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28634
agctttcttt ggcagcctat                                                   20


<210> 28635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28635
gctttctttg gcagcctatg                                                   20


<210> 28636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28636
tctttggcag cctatggggt                                                   20


<210> 28637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28637
ctttggcagc ctatggggtt                                                   20


<210> 28638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28638
cctatggggt tgggtgatga                                                   20


<210> 28639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28639
ctatggggtt gggtgatgac                                                   20


<210> 28640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28640
tatggggttg ggtgatgaca                                                   20


<210> 28641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28641
ggggttgggt gatgacaggg                                                   20


<210> 28642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28642
gttgggtgat gacagggaag                                                   20


<210> 28643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28643
ggtgatgaca gggaagaagc                                                   20


<210> 28644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28644
gtgatgacag ggaagaagct                                                   20


<210> 28645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28645
gggaagaagc tgggatgtca                                                   20


<210> 28646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28646
gaagaagctg ggatgtcaaa                                                   20


<210> 28647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28647
agaagctggg atgtcaaaga                                                   20


<210> 28648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28648
tgggatgtca aagagagatt                                                   20


<210> 28649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28649
gatgtcaaag agagattgag                                                   20


<210> 28650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28650
aagagagatt gagtagtatg                                                   20


<210> 28651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28651
agagagattg agtagtatgt                                                   20


<210> 28652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28652
gagagattga gtagtatgtg                                                   20


<210> 28653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28653
agagattgag tagtatgtgg                                                   20


<210> 28654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28654
gattgagtag tatgtggggg                                                   20


<210> 28655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28655
attgagtagt atgtggggga                                                   20


<210> 28656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28656
aaaactttca tgtttttgcc                                                   20


<210> 28657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28657
aaactttcat gtttttgcca                                                   20


<210> 28658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28658
aactttcatg tttttgccaa                                                   20


<210> 28659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28659
tttttgccaa gggttgtccc                                                   20


<210> 28660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28660
gtccctagca cacacctcct                                                   20


<210> 28661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28661
gcacacacct ccttggcatc                                                   20


<210> 28662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28662
cttggcatct ggctcaaatg                                                   20


<210> 28663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28663
atgtggattc aatcttactc                                                   20


<210> 28664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28664
ttcaatctta ctccagccac                                                   20


<210> 28665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28665
tcttactcca gccacaagta                                                   20


<210> 28666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28666
cttactccag ccacaagtaa                                                   20


<210> 28667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28667
ctccagccac aagtaaaggc                                                   20


<210> 28668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28668
gccacaagta aaggccagtg                                                   20


<210> 28669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28669
agtaaaggcc agtgtggact                                                   20


<210> 28670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28670
ggactcagct gcttgcttct                                                   20


<210> 28671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28671
tcagctgctt gcttctcagt                                                   20


<210> 28672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28672
gcttgcttct cagtaagtct                                                   20


<210> 28673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28673
cttgcttctc agtaagtctt                                                   20


<210> 28674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28674
ttgcttctca gtaagtctta                                                   20


<210> 28675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28675
cattacccat gacttgaatg                                                   20


<210> 28676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28676
acccatgact tgaatgtggt                                                   20


<210> 28677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28677
cccatgactt gaatgtggtt                                                   20


<210> 28678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28678
acttgaatgt ggttgggact                                                   20


<210> 28679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28679
tttcacctaa ttttaatttt                                                   20


<210> 28680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28680
ctctccactg aacttgttga                                                   20


<210> 28681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28681
ctccactgaa cttgttgatg                                                   20


<210> 28682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28682
tccactgaac ttgttgatgg                                                   20


<210> 28683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28683
ccactgaact tgttgatgga                                                   20


<210> 28684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28684
ttgatggagg gatactcaat                                                   20


<210> 28685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28685
gagggatact caatgagcct                                                   20


<210> 28686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28686
agggatactc aatgagccta                                                   20


<210> 28687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28687
tgagcctaag gacttttgct                                                   20


<210> 28688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28688
gagcctaagg acttttgctc                                                   20


<210> 28689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28689
tgctcaggtt cactcaaatc                                                   20


<210> 28690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28690
atccagttat cttgattgta                                                   20


<210> 28691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28691
tccagttatc ttgattgtat                                                   20


<210> 28692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28692
tcttgattgt atgggtgatt                                                   20


<210> 28693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28693
cttgattgta tgggtgattt                                                   20


<210> 28694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28694
gattgtatgg gtgatttagg                                                   20


<210> 28695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28695
gtatgggtga tttaggaaga                                                   20


<210> 28696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28696
ggaagaaagc tgtgccccta                                                   20


<210> 28697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28697
aagaaagctg tgcccctaca                                                   20


<210> 28698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28698
agaaagctgt gcccctacag                                                   20


<210> 28699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28699
cccattgtaa tacttcttat                                                   20


<210> 28700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28700
taatacttct tatcagaatc                                                   20


<210> 28701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28701
cttcttatca gaatctagac                                                   20


<210> 28702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28702
atgaccacta tttcaaaata                                                   20


<210> 28703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28703
atttcaaaat acagtgtcaa                                                   20


<210> 28704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28704
tttttcactt tgttctgaca                                                   20


<210> 28705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28705
ctttgttctg acaaagtttg                                                   20


<210> 28706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28706
cttgatttaa aaaaatctaa                                                   20


<210> 28707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28707
tttaaaaaaa tctaatagct                                                   20


<210> 28708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28708
aaatctaata gcttggctaa                                                   20


<210> 28709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28709
gcatgtctcc ataattcatt                                                   20


<210> 28710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28710
catgtctcca taattcattt                                                   20


<210> 28711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28711
atgtctccat aattcattta                                                   20


<210> 28712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28712
ctccataatt catttaggga                                                   20


<210> 28713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28713
tccataattc atttagggaa                                                   20


<210> 28714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28714
ttcctttgtt aaatgtcctt                                                   20


<210> 28715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28715
ctttggactt ttcccttgtg                                                   20


<210> 28716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28716
tttggacttt tcccttgtgt                                                   20


<210> 28717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28717
ttggactttt cccttgtgtg                                                   20


<210> 28718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28718
gacttttccc ttgtgtgggg                                                   20


<210> 28719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28719
acttttccct tgtgtgggga                                                   20


<210> 28720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28720
cttttccctt gtgtggggaa                                                   20


<210> 28721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28721
ggctaatgaa attgtgtcat                                                   20


<210> 28722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28722
tcttcactaa tgctgcatct                                                   20


<210> 28723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28723
ctaatgctgc atcttagcca                                                   20


<210> 28724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28724
tgctgcatct tagccacaga                                                   20


<210> 28725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28725
ttagccacag aaagtttatg                                                   20


<210> 28726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28726
gccacagaaa gtttatgtag                                                   20


<210> 28727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28727
ccacagaaag tttatgtaga                                                   20


<210> 28728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28728
aaagtttatg tagaaggaca                                                   20


<210> 28729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28729
aagtttatgt agaaggacac                                                   20


<210> 28730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28730
agtttatgta gaaggacaca                                                   20


<210> 28731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28731
acagggccaa ttccattcac                                                   20


<210> 28732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28732
agggccaatt ccattcactg                                                   20


<210> 28733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28733
gccaattcca ttcactggag                                                   20


<210> 28734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28734
attccattca ctggagtgga                                                   20


<210> 28735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28735
attcactgga gtggatggct                                                   20


<210> 28736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28736
gatggctcag aaattctttg                                                   20


<210> 28737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28737
ctgttcatcc attcccaaaa                                                   20


<210> 28738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28738
ttcccaaaaa agtgctatct                                                   20


<210> 28739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28739
tcccaaaaaa gtgctatctt                                                   20


<210> 28740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28740
cccaaaaaag tgctatctta                                                   20


<210> 28741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28741
agtgctatct tagggcctct                                                   20


<210> 28742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28742
tgctatctta gggcctctca                                                   20


<210> 28743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28743
gctatcttag ggcctctcag                                                   20


<210> 28744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28744
gcttgatgtt ttctatcttc                                                   20


<210> 28745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28745
tgatgttttc tatcttctgg                                                   20


<210> 28746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28746
tgttttctat cttctggcag                                                   20


<210> 28747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28747
ctatcttctg gcagaagact                                                   20


<210> 28748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28748
tcttctggca gaagactgag                                                   20


<210> 28749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28749
gcagaagact gagaagaact                                                   20


<210> 28750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28750
cagaagactg agaagaactt                                                   20


<210> 28751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28751
aacttaggtg atatcatgtg                                                   20


<210> 28752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28752
aggtgatatc atgtgtggta                                                   20


<210> 28753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28753
ggtgatatca tgtgtggtat                                                   20


<210> 28754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28754
gatatcatgt gtggtatggg                                                   20


<210> 28755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28755
ggtatgggta gtacatttaa                                                   20


<210> 28756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28756
tatgggtagt acatttaatg                                                   20


<210> 28757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28757
atgggtagta catttaatgg                                                   20


<210> 28758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28758
acatttaatg gaggaacgca                                                   20


<210> 28759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28759
aacgcaaagc catgtctctt                                                   20


<210> 28760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28760
tcttgagatc tttatgaaaa                                                   20


<210> 28761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28761
cttgagatct ttatgaaaaa                                                   20


<210> 28762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28762
tgagatcttt atgaaaaaag                                                   20


<210> 28763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28763
tatgaaaaaa ggagtgaaac                                                   20


<210> 28764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28764
tgaaaaaagg agtgaaacta                                                   20


<210> 28765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28765
aaaggagtga aactagagtc                                                   20


<210> 28766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28766
tttgcccaat ctttaaactc                                                   20


<210> 28767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28767
gcccaatctt taaactcgag                                                   20


<210> 28768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28768
cccaatcttt aaactcgagt                                                   20


<210> 28769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28769
aactcgagtg ggataacttt                                                   20


<210> 28770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28770
ggataacttt tggttcctac                                                   20


<210> 28771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28771
gataactttt ggttcctact                                                   20


<210> 28772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28772
ccactaccat gactgcatct                                                   20


<210> 28773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28773
gactgcatct tggatcctga                                                   20


<210> 28774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28774
actgcatctt ggatcctgac                                                   20


<210> 28775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28775
ctgcatcttg gatcctgaca                                                   20


<210> 28776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28776
tgcatcttgg atcctgacag                                                   20


<210> 28777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28777
catcttggat cctgacaggg                                                   20


<210> 28778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28778
ttggatcctg acaggggagt                                                   20


<210> 28779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28779
tggatcctga caggggagtt                                                   20


<210> 28780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28780
tcatttcctc tctatacctg                                                   20


<210> 28781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28781
catttcctct ctatacctgt                                                   20


<210> 28782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28782
cctctctata cctgtaggcg                                                   20


<210> 28783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28783
ctctctatac ctgtaggcgt                                                   20


<210> 28784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28784
tctctatacc tgtaggcgtg                                                   20


<210> 28785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28785
ctatacctgt aggcgtgggg                                                   20


<210> 28786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28786
tgtaggcgtg gggtagaata                                                   20


<210> 28787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28787
gtaggcgtgg ggtagaatat                                                   20


<210> 28788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28788
taggcgtggg gtagaatata                                                   20


<210> 28789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28789
ggtagaatat agggtgatac                                                   20


<210> 28790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28790
tagaatatag ggtgatactg                                                   20


<210> 28791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28791
actggagatc tactgcgacc                                                   20


<210> 28792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28792
accatgatac ataaccacac                                                   20


<210> 28793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28793
aaccacacaa gtttaatccc                                                   20


<210> 28794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28794
accacacaag tttaatccct                                                   20


<210> 28795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28795
taactaccct tactgtcact                                                   20


<210> 28796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28796
tacttgaact ctaaaactgt                                                   20


<210> 28797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28797
cttgaactct aaaactgttg                                                   20


<210> 28798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28798
ctaaaactgt tggagaaact                                                   20


<210> 28799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28799
aaactcagtg cttcccccaa                                                   20


<210> 28800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28800
cccaacagat tcatttcaaa                                                   20


<210> 28801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28801
ttcatttcaa atagctgtaa                                                   20


<210> 28802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28802
tcatttcaaa tagctgtaaa                                                   20


<210> 28803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28803
tgtaaaaggt atgtttactc                                                   20


<210> 28804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28804
aaaaggtatg tttactccag                                                   20


<210> 28805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28805
gtatgtttac tccagaagac                                                   20


<210> 28806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28806
atgtttactc cagaagacca                                                   20


<210> 28807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28807
cttttgaact tctcattcct                                                   20


<210> 28808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28808
ttttgaactt ctcattcctt                                                   20


<210> 28809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28809
aacttctcat tccttgggcc                                                   20


<210> 28810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28810
acttctcatt ccttgggcct                                                   20


<210> 28811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28811
ccctcatccc aacgtcaacc                                                   20


<210> 28812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28812
cagatcttct cttccataaa                                                   20


<210> 28813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28813
ttccataaac agcactccct                                                   20


<210> 28814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28814
tccataaaca gcactccctc                                                   20


<210> 28815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28815
cctcaggccc ctgcctgaca                                                   20


<210> 28816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28816
ctcaggcccc tgcctgacac                                                   20


<210> 28817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28817
gcccctgcct gacacaggca                                                   20


<210> 28818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28818
acaggcatag actgtcatgt                                                   20


<210> 28819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28819
agactgtcat gttggattca                                                   20


<210> 28820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28820
tgtcatgttg gattcacaga                                                   20


<210> 28821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28821
gtcatgttgg attcacagac                                                   20


<210> 28822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28822
gattcacaga caggctgtgc                                                   20


<210> 28823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28823
ttcacagaca ggctgtgcta                                                   20


<210> 28824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28824
tcacagacag gctgtgctag                                                   20


<210> 28825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28825
gctgtgctag aggaaacctc                                                   20


<210> 28826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28826
ctgtgctaga ggaaacctct                                                   20


<210> 28827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28827
tgtgctagag gaaacctctg                                                   20


<210> 28828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28828
aggaaacctc tggggctcac                                                   20


<210> 28829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28829
ggaaacctct ggggctcacc                                                   20


<210> 28830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28830
gaaacctctg gggctcacca                                                   20


<210> 28831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28831
aaacctctgg ggctcaccag                                                   20


<210> 28832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28832
ctggggctca ccaggggccg                                                   20


<210> 28833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28833
tggggctcac caggggccgt                                                   20


<210> 28834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28834
gctcaccagg ggccgtggga                                                   20


<210> 28835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28835
ctcaccaggg gccgtgggat                                                   20


<210> 28836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28836
ggggccgtgg gatgggcttc                                                   20


<210> 28837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28837
gggccgtggg atgggcttct                                                   20


<210> 28838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28838
ggccgtggga tgggcttctg                                                   20


<210> 28839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28839
gatgggcttc tggggcttct                                                   20


<210> 28840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28840
tgggcttctg gggcttcttg                                                   20


<210> 28841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28841
cttggagccc aacttcttca                                                   20


<210> 28842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28842
ccaacttctt catggcattg                                                   20


<210> 28843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28843
tcttctgctc ctctgtcatg                                                   20


<210> 28844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28844
cctctgtcat gaagatgtcc                                                   20


<210> 28845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28845
tgaagatgtc ctggccccct                                                   20


<210> 28846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28846
atgtcctggc cccctaagtg                                                   20


<210> 28847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28847
gtcctggccc cctaagtgca                                                   20


<210> 28848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28848
cctggccccc taagtgcaga                                                   20


<210> 28849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28849
ctggccccct aagtgcagag                                                   20


<210> 28850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28850
tggcccccta agtgcagaga                                                   20


<210> 28851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28851
agagggccac actgttacta                                                   20


<210> 28852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28852
ggccacactg ttactaaagc                                                   20


<210> 28853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28853
ccacactgtt actaaagcaa                                                   20


<210> 28854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28854
cacactgtta ctaaagcaag                                                   20


<210> 28855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 28855
aaagcaagag gaacccccta                                                   20


<210> 28856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28856
ccccctacgg ataccaaaat                                                   20


<210> 28857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28857
tacggatacc aaaatcagaa                                                   20


<210> 28858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28858
acggatacca aaatcagaac                                                   20


<210> 28859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28859
gataccaaaa tcagaacagg                                                   20


<210> 28860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28860
ataccaaaat cagaacaggc                                                   20


<210> 28861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28861
accaaaatca gaacaggcag                                                   20


<210> 28862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28862
caaaatcaga acaggcagga                                                   20


<210> 28863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28863
atcagaacag gcaggagaga                                                   20


<210> 28864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28864
tcagaacagg caggagagaa                                                   20


<210> 28865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28865
caaccttctc ccctcctctg                                                   20


<210> 28866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28866
cttctcccct cctctgcaga                                                   20


<210> 28867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28867
cctctgcaga tagacaaacc                                                   20


<210> 28868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28868
gcagatagac aaaccaagcc                                                   20


<210> 28869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28869
gacaaaccaa gcccagcatc                                                   20


<210> 28870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28870
acaaaccaag cccagcatca                                                   20


<210> 28871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28871
aaaccaagcc cagcatcaag                                                   20


<210> 28872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28872
aaggagtgtc ttgccacatc                                                   20


<210> 28873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 28873
tgtcttgcca catccagtgt                                                   20


<210> 28874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 28874
tgccacatcc agtgtcggaa                                                   20


<210> 28875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28875
cacatccagt gtcggaacgg                                                   20


<210> 28876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28876
acatccagtg tcggaacggt                                                   20


<210> 28877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28877
agtgtcggaa cggtgggact                                                   20


<210> 28878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28878
tccattgctg actccctgcc                                                   20


<210> 28879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28879
ccattgctga ctccctgcct                                                   20


<210> 28880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28880
actccctgcc tgggtctcta                                                   20


<210> 28881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28881
ctgcctgggt ctctaaagca                                                   20


<210> 28882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28882
ctgggtctct aaagcaaagc                                                   20


<210> 28883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28883
caaagccagt ttctgttctc                                                   20


<210> 28884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28884
aaagccagtt tctgttctcc                                                   20


<210> 28885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28885
aagccagttt ctgttctcca                                                   20


<210> 28886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28886
gtttctgttc tccagggatc                                                   20


<210> 28887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28887
ttctgttctc cagggatcca                                                   20


<210> 28888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28888
ctccagggat ccagagatgc                                                   20


<210> 28889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28889
ggatccagag atgctggata                                                   20


<210> 28890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28890
gatccagaga tgctggataa                                                   20


<210> 28891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28891
atccagagat gctggataaa                                                   20


<210> 28892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28892
cagagatgct ggataaaggg                                                   20


<210> 28893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28893
agagatgctg gataaagggt                                                   20


<210> 28894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28894
gagatgctgg ataaagggtg                                                   20


<210> 28895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28895
gatgctggat aaagggtggg                                                   20


<210> 28896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28896
atgctggata aagggtgggg                                                   20


<210> 28897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28897
tgctggataa agggtgggga                                                   20


<210> 28898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28898
ggataaaggg tggggagggt                                                   20


<210> 28899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28899
gggtggggag ggttggtaaa                                                   20


<210> 28900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28900
ggtggggagg gttggtaaac                                                   20


<210> 28901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28901
agggttggta aacaggactc                                                   20


<210> 28902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28902
gggttggtaa acaggactca                                                   20


<210> 28903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28903
gttggtaaac aggactcaag                                                   20


<210> 28904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28904
ggtaaacagg actcaaggag                                                   20


<210> 28905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28905
gtaaacagga ctcaaggaga                                                   20


<210> 28906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28906
ctcaaggaga aggtacatgt                                                   20


<210> 28907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28907
gtacatgttg gttcaaatct                                                   20


<210> 28908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28908
gttggttcaa atctgagcct                                                   20


<210> 28909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28909
tcaaatctga gccttggatc                                                   20


<210> 28910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28910
tggatctagc ctgttcattc                                                   20


<210> 28911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28911
ttcattccag taaaattctt                                                   20


<210> 28912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28912
tcattccagt aaaattcttt                                                   20


<210> 28913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28913
agtaaaattc tttgggcttc                                                   20


<210> 28914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28914
taaaattctt tgggcttcta                                                   20


<210> 28915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28915
tctttgggct tctagagtca                                                   20


<210> 28916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28916
tctagagtca cagtccctcc                                                   20


<210> 28917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28917
ctagagtcac agtccctccc                                                   20


<210> 28918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28918
tagagtcaca gtccctccca                                                   20


<210> 28919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28919
agagtcacag tccctcccag                                                   20


<210> 28920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28920
gagtcacagt ccctcccagg                                                   20


<210> 28921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28921
cacagtccct cccagggggc                                                   20


<210> 28922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28922
cagtccctcc cagggggcaa                                                   20


<210> 28923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28923
cagggggcaa gagatttcct                                                   20


<210> 28924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28924
agggggcaag agatttcctg                                                   20


<210> 28925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28925
gagatttcct gaggaccttg                                                   20


<210> 28926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28926
ttcctgagga ccttgaagca                                                   20


<210> 28927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28927
ggaccttgaa gcaaagactc                                                   20


<210> 28928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28928
gaccttgaag caaagactct                                                   20


<210> 28929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28929
ccttgaagca aagactctgg                                                   20


<210> 28930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28930
cttgaagcaa agactctggg                                                   20


<210> 28931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28931
ttgaagcaaa gactctggga                                                   20


<210> 28932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28932
agcaaagact ctgggaggga                                                   20


<210> 28933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28933
aaagactctg ggagggacag                                                   20


<210> 28934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28934
agaagccctc aaatcttttc                                                   20


<210> 28935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28935
aagccctcaa atcttttctg                                                   20


<210> 28936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28936
gccctcaaat cttttctgga                                                   20


<210> 28937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28937
ccctcaaatc ttttctggag                                                   20


<210> 28938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28938
ctcaaatctt ttctggagag                                                   20


<210> 28939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28939
tcaaatcttt tctggagagg                                                   20


<210> 28940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28940
aaatcttttc tggagaggag                                                   20


<210> 28941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28941
ttttctggag aggaggagat                                                   20


<210> 28942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28942
tttctggaga ggaggagatg                                                   20


<210> 28943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28943
gacaattact gccttatcct                                                   20


<210> 28944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28944
acaattactg ccttatcctt                                                   20


<210> 28945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28945
ctgccttatc cttgggtcct                                                   20


<210> 28946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28946
tatccttggg tccttggtct                                                   20


<210> 28947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28947
tccttgggtc cttggtctca                                                   20


<210> 28948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28948
ccttgggtcc ttggtctcag                                                   20


<210> 28949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28949
cttgggtcct tggtctcaga                                                   20


<210> 28950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28950
cttggtctca gagggacctc                                                   20


<210> 28951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28951
gagggacctc tggttctctt                                                   20


<210> 28952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28952
agggacctct ggttctcttg                                                   20


<210> 28953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28953
tggttctctt gaggccctgc                                                   20


<210> 28954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28954
cacactgccc tctgctgtta                                                   20


<210> 28955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 28955
gccctctgct gttacagtgc                                                   20


<210> 28956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28956
tgccagaaac tgcaccaacg                                                   20


<210> 28957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28957
acgaagatgt tttcctccct                                                   20


<210> 28958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28958
cgaagatgtt ttcctccctt                                                   20


<210> 28959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28959
atgttttcct cccttaggat                                                   20


<210> 28960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28960
tgttttcctc ccttaggatt                                                   20


<210> 28961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28961
cctcccttag gattgggtat                                                   20


<210> 28962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28962
attgggtatt agtttttctt                                                   20


<210> 28963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28963
ttgggtatta gtttttcttt                                                   20


<210> 28964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28964
tgggtattag tttttcttta                                                   20


<210> 28965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28965
gggtattagt ttttctttag                                                   20


<210> 28966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28966
gtttttcttt aggggccctt                                                   20


<210> 28967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28967
ttcattcaaa ctctcacctt                                                   20


<210> 28968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28968
agcttcctga cataatttga                                                   20


<210> 28969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28969
ttttaataac atgtttatgt                                                   20


<210> 28970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 28970
aataacatgt ttatgtaagt                                                   20


<210> 28971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28971
aagttagtcc ctgcaaatgc                                                   20


<210> 28972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28972
agttagtccc tgcaaatgct                                                   20


<210> 28973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28973
ccctgcaaat gctgggaaac                                                   20


<210> 28974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28974
cctgcaaatg ctgggaaact                                                   20


<210> 28975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28975
aaatgctggg aaactgggct                                                   20


<210> 28976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28976
ggaaactggg ctgagatctg                                                   20


<210> 28977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28977
ctgagatctg tggaatttga                                                   20


<210> 28978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28978
tgagatctgt ggaatttgaa                                                   20


<210> 28979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28979
agatctgtgg aatttgaaag                                                   20


<210> 28980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28980
tggaatttga aaggagatct                                                   20


<210> 28981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28981
aatttgaaag gagatctgag                                                   20


<210> 28982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28982
aggagatctg agaagatctg                                                   20


<210> 28983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28983
tgagaagatc tgtggacaca                                                   20


<210> 28984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28984
gagaagatct gtggacacaa                                                   20


<210> 28985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28985
agaagatctg tggacacaaa                                                   20


<210> 28986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28986
tgtggacaca aagggcttcc                                                   20


<210> 28987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28987
gtggacacaa agggcttcct                                                   20


<210> 28988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28988
ggacacaaag ggcttcctgg                                                   20


<210> 28989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28989
gacacaaagg gcttcctggg                                                   20


<210> 28990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 28990
tcctgggagg accatcttta                                                   20


<210> 28991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28991
cctgggagga ccatctttat                                                   20


<210> 28992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28992
ctgggaggac catctttatg                                                   20


<210> 28993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28993
tgggaggacc atctttatgg                                                   20


<210> 28994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 28994
gggaggacca tctttatggg                                                   20


<210> 28995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28995
gaggaccatc tttatggggg                                                   20


<210> 28996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 28996
ggaccatctt tatgggggga                                                   20


<210> 28997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28997
ccatctttat ggggggagag                                                   20


<210> 28998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 28998
catctttatg gggggagaga                                                   20


<210> 28999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 28999
tttatggggg gagagaagga                                                   20


<210> 29000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29000
ttatgggggg agagaaggaa                                                   20


<210> 29001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29001
tatgggggga gagaaggaaa                                                   20


<210> 29002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29002
gggggagaga aggaaagggc                                                   20


<210> 29003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29003
ggggagagaa ggaaagggca                                                   20


<210> 29004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29004
gggagagaag gaaagggcaa                                                   20


<210> 29005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29005
agagaaggaa agggcaaggg                                                   20


<210> 29006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29006
gaaggaaagg gcaagggcag                                                   20


<210> 29007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29007
aaggaaaggg caagggcagt                                                   20


<210> 29008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29008
gaaagggcaa gggcagtggg                                                   20


<210> 29009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29009
aaagggcaag ggcagtgggt                                                   20


<210> 29010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29010
ggcaagggca gtgggtaggt                                                   20


<210> 29011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29011
ggcagtgggt aggtgagctc                                                   20


<210> 29012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29012
gcagtgggta ggtgagctcc                                                   20


<210> 29013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29013
tgggtaggtg agctccaggt                                                   20


<210> 29014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29014
gggtaggtga gctccaggtg                                                   20


<210> 29015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29015
gctccaggtg aggtcatgct                                                   20


<210> 29016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29016
tcatgctgag aactctgacc                                                   20


<210> 29017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29017
catgctgaga actctgacca                                                   20


<210> 29018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29018
gagaactctg accaaggatt                                                   20


<210> 29019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29019
aactctgacc aaggattcag                                                   20


<210> 29020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29020
gaccaaggat tcagtagatg                                                   20


<210> 29021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29021
attcagtaga tgcagtttct                                                   20


<210> 29022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29022
atgcagtttc tcagtgaccc                                                   20


<210> 29023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29023
gtttctcagt gaccccagcc                                                   20


<210> 29024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29024
agtgacccca gcctggtcac                                                   20


<210> 29025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29025
tgtaatctgt ttcttgacct                                                   20


<210> 29026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29026
agttttctca tctgtaaaat                                                   20


<210> 29027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29027
ttttctcatc tgtaaaatga                                                   20


<210> 29028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29028
tcaataatct caaacctccc                                                   20


<210> 29029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29029
caataatctc aaacctcccc                                                   20


<210> 29030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29030
aataatctca aacctcccca                                                   20


<210> 29031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29031
aacctcccca gggtactaaa                                                   20


<210> 29032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29032
taaatagcac tgtcttgtcc                                                   20


<210> 29033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29033
tcctgtcctc ttcttatgct                                                   20


<210> 29034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29034
tcttcttatg ctcagaaccc                                                   20


<210> 29035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29035
cttcttatgc tcagaaccct                                                   20


<210> 29036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29036
ttatgctcag aaccctgggc                                                   20


<210> 29037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29037
tatgctcaga accctgggca                                                   20


<210> 29038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29038
cctgggcaag gatttcctgt                                                   20


<210> 29039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29039
gggcaaggat ttcctgtaag                                                   20


<210> 29040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29040
tgtaagtgga atgcctgccc                                                   20


<210> 29041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29041
aagtggaatg cctgccctag                                                   20


<210> 29042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29042
agtggaatgc ctgccctagt                                                   20


<210> 29043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29043
tatatatttt aaattgttaa                                                   20


<210> 29044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29044
ttttaaattg ttaatagcaa                                                   20


<210> 29045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29045
ttgttaatag caacagcatc                                                   20


<210> 29046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29046
caacagcatc tggtgctctt                                                   20


<210> 29047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29047
aacagcatct ggtgctcttg                                                   20


<210> 29048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29048
tggtgctctt gaggcgctgc                                                   20


<210> 29049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29049
cacactcccc tctgctgtta                                                   20


<210> 29050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29050
cccctctgct gttacagtgc                                                   20


<210> 29051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29051
tgccagaaac tgcaccacca                                                   20


<210> 29052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29052
caccaaagtt gtcttatgct                                                   20


<210> 29053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29053
tatgctcagt gatctttgtt                                                   20


<210> 29054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29054
atgctcagtg atctttgttc                                                   20


<210> 29055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29055
gtttacccct caccacaatc                                                   20


<210> 29056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29056
ttacccctca ccacaatcca                                                   20


<210> 29057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29057
acccctcacc acaatccaga                                                   20


<210> 29058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29058
cctcaccaca atccagagag                                                   20


<210> 29059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29059
ctcaccacaa tccagagagt                                                   20


<210> 29060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29060
atccagagag taggtattat                                                   20


<210> 29061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29061
attagcccca ttgaatgaat                                                   20


<210> 29062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29062
attgaatgaa tgagaaaact                                                   20


<210> 29063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29063
tgaatgagaa aactgagact                                                   20


<210> 29064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29064
aatgagaaaa ctgagactca                                                   20


<210> 29065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29065
atgagaaaac tgagactcag                                                   20


<210> 29066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29066
tgagaaaact gagactcaga                                                   20


<210> 29067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29067
gagaaaactg agactcagag                                                   20


<210> 29068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29068
agaggggttt aaaatattgc                                                   20


<210> 29069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29069
gtttaaaata ttgccagcat                                                   20


<210> 29070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29070
tgccagcatg agccatccac                                                   20


<210> 29071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29071
cagcatgagc catccacaag                                                   20


<210> 29072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29072
tgagccatcc acaagtagtt                                                   20


<210> 29073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29073
ccatccacaa gtagttgagt                                                   20


<210> 29074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29074
catccacaag tagttgagtc                                                   20


<210> 29075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29075
ttgagtcagg aatgcaaacc                                                   20


<210> 29076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29076
tgagtcagga atgcaaaccc                                                   20


<210> 29077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29077
tactctgtga cttatccatg                                                   20


<210> 29078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 29078
ccatgtagcc ccttttctct                                                   20


<210> 29079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29079
catgtagccc cttttctctc                                                   20


<210> 29080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29080
ccccttttct ctcgggatct                                                   20


<210> 29081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29081
ggatctcagt tacgcaaatc                                                   20


<210> 29082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29082
tcagttacgc aaatctagaa                                                   20


<210> 29083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29083
agaacagcgc ctatctacct                                                   20


<210> 29084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29084
gaacagcgcc tatctacctc                                                   20


<210> 29085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29085
aacagcgcct atctacctca                                                   20


<210> 29086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29086
acagcgccta tctacctcag                                                   20


<210> 29087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29087
gcctatctac ctcaggggta                                                   20


<210> 29088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29088
tatctacctc aggggtatgg                                                   20


<210> 29089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29089
atctacctca ggggtatgga                                                   20


<210> 29090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29090
gtatggaagg cattaaatga                                                   20


<210> 29091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29091
tatggaaggc attaaatgaa                                                   20


<210> 29092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29092
ggcattaaat gaaaggataa                                                   20


<210> 29093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29093
gcattaaatg aaaggataat                                                   20


<210> 29094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29094
tgacattttc ttataaacat                                                   20


<210> 29095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29095
acattttctt ataaacatga                                                   20


<210> 29096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29096
cattttctta taaacatgag                                                   20


<210> 29097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29097
tataaacatg agaggttatc                                                   20


<210> 29098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29098
ataaacatga gaggttatct                                                   20


<210> 29099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29099
gggattcgat tcctattaat                                                   20


<210> 29100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29100
gattcgattc ctattaatca                                                   20


<210> 29101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 29101
cgattcctat taatcagagt                                                   20


<210> 29102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29102
ttaatcagag tcggcaccct                                                   20


<210> 29103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29103
aatcagagtc ggcacccttg                                                   20


<210> 29104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29104
atcagagtcg gcacccttgg                                                   20


<210> 29105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29105
gtcggcaccc ttggaggcac                                                   20


<210> 29106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29106
caagccttcc tccccatccc                                                   20


<210> 29107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29107
aagccttcct ccccatccca                                                   20


<210> 29108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29108
gccttcctcc ccatcccaag                                                   20


<210> 29109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29109
ccttcctccc catcccaagg                                                   20


<210> 29110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29110
cttcctcccc atcccaagga                                                   20


<210> 29111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29111
ctccccatcc caaggagggt                                                   20


<210> 29112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29112
tccccatccc aaggagggtt                                                   20


<210> 29113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29113
aaggagggtt gggattctgc                                                   20


<210> 29114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29114
ggttgggatt ctgccagtgc                                                   20


<210> 29115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29115
gttgggattc tgccagtgct                                                   20


<210> 29116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29116
attctgccag tgctgggcca                                                   20


<210> 29117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29117
gctgggccat ggcctttcct                                                   20


<210> 29118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29118
ctgggccatg gcctttcctg                                                   20


<210> 29119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29119
tttcctgagg tgccctgact                                                   20


<210> 29120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29120
tgccctgact cagtcctttg                                                   20


<210> 29121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29121
gccctgactc agtcctttgt                                                   20


<210> 29122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29122
ccctgactca gtcctttgtg                                                   20


<210> 29123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29123
gtggggatca tatcccccaa                                                   20


<210> 29124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29124
tggggatcat atcccccaac                                                   20


<210> 29125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29125
gatcatatcc cccaacaggt                                                   20


<210> 29126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29126
atatccccca acaggtcagc                                                   20


<210> 29127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29127
cccaacaggt cagcaagttc                                                   20


<210> 29128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29128
tttccctgct tgtattctcc                                                   20


<210> 29129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29129
ttccctgctt gtattctccc                                                   20


<210> 29130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29130
tccctgcttg tattctccca                                                   20


<210> 29131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29131
gtattctccc agggctcact                                                   20


<210> 29132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29132
tggaacacat ctaacacacc                                                   20


<210> 29133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29133
acatctaaca cacctggttc                                                   20


<210> 29134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29134
ctaacacacc tggttccagt                                                   20


<210> 29135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29135
taacacacct ggttccagtt                                                   20


<210> 29136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29136
cacacctggt tccagttggg                                                   20


<210> 29137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29137
tggttccagt tgggaagacc                                                   20


<210> 29138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29138
gggaagacca agatcccttt                                                   20


<210> 29139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29139
ccctttgaga tgtgaatcct                                                   20


<210> 29140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29140
ttgagatgtg aatcctgagt                                                   20


<210> 29141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29141
tgagatgtga atcctgagtg                                                   20


<210> 29142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29142
tgaatcctga gtgaggatgt                                                   20


<210> 29143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29143
atcctgagtg aggatgttag                                                   20


<210> 29144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29144
tcctgagtga ggatgttagt                                                   20


<210> 29145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29145
cctgagtgag gatgttagtg                                                   20


<210> 29146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29146
tgttagtggg gcattgctga                                                   20


<210> 29147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29147
ttagtggggc attgctgaca                                                   20


<210> 29148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29148
agtggggcat tgctgacaga                                                   20


<210> 29149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29149
aaatgcaact cttcctgcaa                                                   20


<210> 29150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29150
tcttcctgca acagcaatca                                                   20


<210> 29151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29151
cttcctgcaa cagcaatcac                                                   20


<210> 29152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29152
ttcctgcaac agcaatcaca                                                   20


<210> 29153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29153
tgcaacagca atcacagggc                                                   20


<210> 29154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29154
gcaacagcaa tcacagggca                                                   20


<210> 29155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29155
caacagcaat cacagggcaa                                                   20


<210> 29156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29156
agcaatcaca gggcaagggt                                                   20


<210> 29157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29157
aagggttagc actgatatta                                                   20


<210> 29158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29158
tagcactgat attaaagtga                                                   20


<210> 29159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29159
agcactgata ttaaagtgat                                                   20


<210> 29160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29160
atattaaagt gatgggctgt                                                   20


<210> 29161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29161
ttaaagtgat gggctgtgag                                                   20


<210> 29162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29162
tgatgggctg tgagtagtgt                                                   20


<210> 29163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29163
tgagtagtgt tggcttttgt                                                   20


<210> 29164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29164
gagtagtgtt ggcttttgtc                                                   20


<210> 29165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29165
gtagtgttgg cttttgtcag                                                   20


<210> 29166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29166
tagtgttggc ttttgtcagg                                                   20


<210> 29167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29167
gttggctttt gtcaggaggc                                                   20


<210> 29168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29168
tggcttttgt caggaggcca                                                   20


<210> 29169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29169
ttttgtcagg aggccagagc                                                   20


<210> 29170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29170
tttgtcagga ggccagagct                                                   20


<210> 29171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29171
gtcaggaggc cagagctggg                                                   20


<210> 29172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29172
tcaggaggcc agagctgggc                                                   20


<210> 29173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29173
caggaggcca gagctgggca                                                   20


<210> 29174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29174
ggccagagct gggcagggaa                                                   20


<210> 29175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29175
gccagagctg ggcagggaac                                                   20


<210> 29176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29176
gggcagggaa caggaaatat                                                   20


<210> 29177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29177
ggcagggaac aggaaatata                                                   20


<210> 29178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29178
aaatataagg cttaccacta                                                   20


<210> 29179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29179
tataaggctt accactacag                                                   20


<210> 29180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29180
cttaccacta cagcagaaac                                                   20


<210> 29181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29181
agcagaaacc agaaactcct                                                   20


<210> 29182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29182
tctttttttt ctgttgattg                                                   20


<210> 29183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29183
tgtcaattat gaccccaaca                                                   20


<210> 29184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29184
tcaattatga ccccaacaaa                                                   20


<210> 29185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29185
atgaccccaa caaagagatt                                                   20


<210> 29186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29186
caacaaagag attcagtgtg                                                   20


<210> 29187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29187
caaagagatt cagtgtgaag                                                   20


<210> 29188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29188
agaagcctcc aaaaatgatg                                                   20


<210> 29189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29189
caaaaatgat gaagatgaca                                                   20


<210> 29190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29190
gtacacgttg tcctcccact                                                   20


<210> 29191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29191
tacacgttgt cctcccactt                                                   20


<210> 29192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29192
gttgcatgtt gacctgtgac                                                   20


<210> 29193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29193
atgttgacct gtgaccagac                                                   20


<210> 29194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29194
tgttgacctg tgaccagaca                                                   20


<210> 29195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29195
gttgacctgt gaccagacaa                                                   20


<210> 29196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29196
tgacctgtga ccagacaagg                                                   20


<210> 29197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29197
acctgtgacc agacaaggga                                                   20


<210> 29198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29198
tgtgaccaga caagggagag                                                   20


<210> 29199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29199
gtgaccagac aagggagagt                                                   20


<210> 29200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29200
accagacaag ggagagtggg                                                   20


<210> 29201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29201
ccagacaagg gagagtggga                                                   20


<210> 29202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29202
agacaaggga gagtgggaag                                                   20


<210> 29203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29203
gacaagggag agtgggaagg                                                   20


<210> 29204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29204
acaagggaga gtgggaagga                                                   20


<210> 29205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29205
agggagagtg ggaaggaggg                                                   20


<210> 29206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29206
gggagagtgg gaaggagggt                                                   20


<210> 29207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29207
gggaaggagg gtgggtgtct                                                   20


<210> 29208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29208
ggagggtggg tgtcttagtt                                                   20


<210> 29209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29209
gagggtgggt gtcttagttc                                                   20


<210> 29210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29210
ttagttcagg ttcactctga                                                   20


<210> 29211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29211
tcaggttcac tctgaaagcc                                                   20


<210> 29212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29212
tcactctgaa agccaagcct                                                   20


<210> 29213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29213
tgaaagccaa gcctaagaca                                                   20


<210> 29214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29214
ccaagcctaa gacatggacc                                                   20


<210> 29215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29215
caagcctaag acatggacct                                                   20


<210> 29216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29216
ctaagacatg gacctgggtg                                                   20


<210> 29217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29217
taagacatgg acctgggtgc                                                   20


<210> 29218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29218
ctgggtgcag gtgatttatc                                                   20


<210> 29219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29219
tgggtgcagg tgatttatct                                                   20


<210> 29220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29220
ggtgcaggtg atttatctgg                                                   20


<210> 29221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29221
gtgcaggtga tttatctggg                                                   20


<210> 29222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29222
atttatctgg gaggtgatcc                                                   20


<210> 29223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29223
tttatctggg aggtgatcca                                                   20


<210> 29224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29224
atctgggagg tgatccaagg                                                   20


<210> 29225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29225
tgggaggtga tccaaggaag                                                   20


<210> 29226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29226
gggaggtgat ccaaggaagc                                                   20


<210> 29227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29227
tgatccaagg aagcaggaat                                                   20


<210> 29228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29228
gatccaagga agcaggaatg                                                   20


<210> 29229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29229
atccaaggaa gcaggaatga                                                   20


<210> 29230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29230
ccaaggaagc aggaatgagg                                                   20


<210> 29231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29231
aggaagcagg aatgagggag                                                   20


<210> 29232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29232
ggaagcagga atgagggagt                                                   20


<210> 29233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29233
gaagcaggaa tgagggagtg                                                   20


<210> 29234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29234
gcaggaatga gggagtgggg                                                   20


<210> 29235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29235
atgagggagt ggggaagaat                                                   20


<210> 29236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 29236
agggagtggg gaagaataag                                                   20


<210> 29237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29237
gggagtgggg aagaataagc                                                   20


<210> 29238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29238
tggggaagaa taagcgggaa                                                   20


<210> 29239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29239
ggggaagaat aagcgggaat                                                   20


<210> 29240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29240
ggaagaataa gcgggaatgg                                                   20


<210> 29241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29241
agaataagcg ggaatgggag                                                   20


<210> 29242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29242
aataagcggg aatgggagaa                                                   20


<210> 29243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29243
gaatgggaga agagcctgtg                                                   20


<210> 29244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29244
atgggagaag agcctgtgaa                                                   20


<210> 29245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29245
tgggagaaga gcctgtgaag                                                   20


<210> 29246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29246
cctgtgaaga ggatgttgtt                                                   20


<210> 29247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29247
gtgaagagga tgttgttaag                                                   20


<210> 29248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29248
tgaagaggat gttgttaagc                                                   20


<210> 29249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29249
gaagaggatg ttgttaagca                                                   20


<210> 29250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29250
tgttaagcag ggcatcattg                                                   20


<210> 29251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29251
gttaagcagg gcatcattgt                                                   20


<210> 29252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29252
ggcatcattg tgggcaactg                                                   20


<210> 29253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29253
caactgaagc gcaatcctac                                                   20


<210> 29254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29254
aactgaagcg caatcctact                                                   20


<210> 29255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29255
actgaagcgc aatcctactg                                                   20


<210> 29256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29256
caatcctact ggggtcctct                                                   20


<210> 29257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29257
gggtcctctg agtaactgtg                                                   20


<210> 29258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29258
gtcctctgag taactgtgta                                                   20


<210> 29259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29259
gtaactgtgt agagcacatg                                                   20


<210> 29260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29260
taactgtgta gagcacatgc                                                   20


<210> 29261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29261
acatgcagga ttatatcacc                                                   20


<210> 29262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29262
catgcaggat tatatcacca                                                   20


<210> 29263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29263
atgcaggatt atatcaccaa                                                   20


<210> 29264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29264
aggattatat caccaaggga                                                   20


<210> 29265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29265
ggattatatc accaagggac                                                   20


<210> 29266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29266
gattatatca ccaagggaca                                                   20


<210> 29267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29267
tcaccaaggg acagggaaac                                                   20


<210> 29268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29268
accaagggac agggaaactg                                                   20


<210> 29269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29269
gaaactggag tatttatcct                                                   20


<210> 29270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29270
ctcagactcc caaaacttat                                                   20


<210> 29271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29271
gactcccaaa acttattggt                                                   20


<210> 29272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29272
actcccaaaa cttattggta                                                   20


<210> 29273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29273
ctcccaaaac ttattggtaa                                                   20


<210> 29274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29274
ttattggtaa gggttgcccc                                                   20


<210> 29275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29275
tattggtaag ggttgcccct                                                   20


<210> 29276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29276
attggtaagg gttgccccta                                                   20


<210> 29277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29277
ccctagggac attaaatccc                                                   20


<210> 29278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29278
gacattaaat ccctggtact                                                   20


<210> 29279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29279
acattaaatc cctggtactt                                                   20


<210> 29280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29280
cattaaatcc ctggtacttg                                                   20


<210> 29281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29281
attaaatccc tggtacttgg                                                   20


<210> 29282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29282
taaatccctg gtacttgggg                                                   20


<210> 29283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29283
atccctggta cttgggggag                                                   20


<210> 29284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29284
tgggggagaa gttgctgcac                                                   20


<210> 29285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29285
aagttgctgc acaagctcct                                                   20


<210> 29286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29286
ctgcacaagc tcctaagccc                                                   20


<210> 29287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29287
gcacaagctc ctaagccctg                                                   20


<210> 29288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29288
taagccctgg agtctttata                                                   20


<210> 29289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29289
agccctggag tctttataca                                                   20


<210> 29290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29290
ggagtcttta tacagagaat                                                   20


<210> 29291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29291
gtctttatac agagaatcag                                                   20


<210> 29292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29292
tatacagaga atcagaagtg                                                   20


<210> 29293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29293
agaatcagaa gtgcagcctg                                                   20


<210> 29294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29294
gaatcagaag tgcagcctgc                                                   20


<210> 29295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29295
gtgcagcctg caggtgaaat                                                   20


<210> 29296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29296
cagcctgcag gtgaaatcag                                                   20


<210> 29297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29297
cctgcaggtg aaatcagaag                                                   20


<210> 29298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29298
ctgcaggtga aatcagaagt                                                   20


<210> 29299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29299
ggtgaaatca gaagtgggct                                                   20


<210> 29300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29300
gtgaaatcag aagtgggcta                                                   20


<210> 29301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29301
tgaaatcaga agtgggctaa                                                   20


<210> 29302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29302
aatcagaagt gggctaaggg                                                   20


<210> 29303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29303
tcagaagtgg gctaagggaa                                                   20


<210> 29304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29304
cagaagtggg ctaagggaag                                                   20


<210> 29305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29305
aagtgggcta agggaagagg                                                   20


<210> 29306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29306
tgggctaagg gaagaggtgg                                                   20


<210> 29307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29307
gggctaaggg aagaggtggc                                                   20


<210> 29308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29308
ggctaaggga agaggtggca                                                   20


<210> 29309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29309
aagaggtggc agggaattga                                                   20


<210> 29310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29310
ggaattgaca gtgcctgcca                                                   20


<210> 29311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29311
attgacagtg cctgccacag                                                   20


<210> 29312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29312
ttgacagtgc ctgccacagc                                                   20


<210> 29313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29313
acagtgcctg ccacagcagg                                                   20


<210> 29314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29314
gtgcctgcca cagcaggaag                                                   20


<210> 29315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29315
aggaagtggt cattccccaa                                                   20


<210> 29316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29316
attccccaat agtgtctccc                                                   20


<210> 29317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29317
ccaatagtgt ctccccagcc                                                   20


<210> 29318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29318
cttttctttt cttttttttt                                                   20


<210> 29319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29319
ttttcttttt ttttgagatt                                                   20


<210> 29320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29320
tgagtctcgc tgtctcgccc                                                   20


<210> 29321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29321
tctcgctgtc tcgcccaagc                                                   20


<210> 29322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29322
tcgctgtctc gcccaagctg                                                   20


<210> 29323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29323
gtctcgccca agctggagtg                                                   20


<210> 29324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29324
ggagtgcagt gacgcaatct                                                   20


<210> 29325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 29325
tcactgcaac ttctgcctcc                                                   20


<210> 29326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29326
cactgcaact tctgcctccc                                                   20


<210> 29327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29327
aacttctgcc tcccgggttc                                                   20


<210> 29328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29328
cttctgcctc ccgggttcaa                                                   20


<210> 29329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29329
ttcaagagat tctcctgtct                                                   20


<210> 29330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29330
ttctcctgtc tcagtctccc                                                   20


<210> 29331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29331
tcctgtctca gtctcccgag                                                   20


<210> 29332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29332
gtctcagtct cccgagcagc                                                   20


<210> 29333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29333
tctcagtctc ccgagcagct                                                   20


<210> 29334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29334
ctcccgagca gctgggacta                                                   20


<210> 29335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29335
tcccgagcag ctgggactac                                                   20


<210> 29336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29336
gcagctggga ctacaggcac                                                   20


<210> 29337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29337
tgctaatttc tttcatattt                                                   20


<210> 29338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29338
taatttcttt catattttag                                                   20


<210> 29339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29339
atttctttca tattttagta                                                   20


<210> 29340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29340
ctttcatatt ttagtagaga                                                   20


<210> 29341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29341
tttcatattt tagtagagat                                                   20


<210> 29342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29342
ttcatatttt agtagagatg                                                   20


<210> 29343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29343
tggggtttca ccgtattgcc                                                   20


<210> 29344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29344
ggggtttcac cgtattgccc                                                   20


<210> 29345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29345
tttcaccgta ttgcccaggc                                                   20


<210> 29346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29346
attgcccagg ctggtctcct                                                   20


<210> 29347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29347
ccaggctggt ctcctgagct                                                   20


<210> 29348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29348
caggctggtc tcctgagctc                                                   20


<210> 29349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 29349
ctcaggcaat ctgcccacct                                                   20


<210> 29350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29350
ctgcccacct cggcctccca                                                   20


<210> 29351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29351
acctcggcct cccaaagtgc                                                   20


<210> 29352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29352
cctcggcctc ccaaagtgct                                                   20


<210> 29353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29353
ctcccaaagt gctaggatta                                                   20


<210> 29354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29354
tcccaaagtg ctaggattac                                                   20


<210> 29355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29355
caggcatgaa ccactgcgcc                                                   20


<210> 29356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29356
ccactgcgcc tggcccatcc                                                   20


<210> 29357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29357
cactgcgcct ggcccatcct                                                   20


<210> 29358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29358
gcccatcctg ggttttatga                                                   20


<210> 29359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29359
tgggttttat gatagttcct                                                   20


<210> 29360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29360
cctccctatg caccttgatt                                                   20


<210> 29361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29361
gctttgctcc cacccttgtc                                                   20


<210> 29362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29362
ctttgctccc acccttgtcc                                                   20


<210> 29363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29363
tttgctccca cccttgtcca                                                   20


<210> 29364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29364
tgctcccacc cttgtccagg                                                   20


<210> 29365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29365
tcccaccctt gtccagggag                                                   20


<210> 29366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29366
ggctcacatg aactgtctct                                                   20


<210> 29367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29367
ctcacatgaa ctgtctctta                                                   20


<210> 29368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29368
tcacatgaac tgtctcttag                                                   20


<210> 29369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29369
ttatctgatg ctttcctcaa                                                   20


<210> 29370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29370
atgctttcct caacagtgaa                                                   20


<210> 29371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29371
gctttcctca acagtgaaca                                                   20


<210> 29372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29372
ctttcctcaa cagtgaacag                                                   20


<210> 29373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29373
agtgaacaga ggaaaacctc                                                   20


<210> 29374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29374
gaacagagga aaacctcgag                                                   20


<210> 29375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29375
gaggaaaacc tcgagaagcc                                                   20


<210> 29376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29376
aggaaaacct cgagaagcct                                                   20


<210> 29377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29377
ggaaaacctc gagaagcctg                                                   20


<210> 29378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29378
aaaacctcga gaagcctggg                                                   20


<210> 29379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29379
ctcgagaagc ctggggagtg                                                   20


<210> 29380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29380
agcctgggga gtgtagatga                                                   20


<210> 29381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29381
gcctggggag tgtagatgaa                                                   20


<210> 29382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29382
cctggggagt gtagatgaaa                                                   20


<210> 29383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29383
ctggggagtg tagatgaaag                                                   20


<210> 29384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29384
tggggagtgt agatgaaagg                                                   20


<210> 29385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29385
gagtgtagat gaaaggggga                                                   20


<210> 29386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 29386
agatgaaagg gggaaagcct                                                   20


<210> 29387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29387
tgaaaggggg aaagcctcgg                                                   20


<210> 29388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29388
tcggtggctg aaacactcaa                                                   20


<210> 29389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29389
ggtggctgaa acactcaaca                                                   20


<210> 29390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29390
tggctgaaac actcaacaga                                                   20


<210> 29391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29391
tgaaacactc aacagagagc                                                   20


<210> 29392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29392
acactcaaca gagagccagc                                                   20


<210> 29393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29393
agccagctgg acactgctgc                                                   20


<210> 29394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29394
gccagctgga cactgctgca                                                   20


<210> 29395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29395
cagctggaca ctgctgcaag                                                   20


<210> 29396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29396
agctggacac tgctgcaagg                                                   20


<210> 29397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29397
gctggacact gctgcaagga                                                   20


<210> 29398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29398
gacactgctg caaggaggga                                                   20


<210> 29399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29399
gctgcaagga gggacagtgt                                                   20


<210> 29400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29400
ctgcaaggag ggacagtgtg                                                   20


<210> 29401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29401
gagggacagt gtgaggttgc                                                   20


<210> 29402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29402
agggacagtg tgaggttgct                                                   20


<210> 29403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29403
tgctgggtga tcgcctcttc                                                   20


<210> 29404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29404
gtgatcgcct cttccagtac                                                   20


<210> 29405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29405
tgatcgcctc ttccagtacc                                                   20


<210> 29406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29406
gatcgcctct tccagtacca                                                   20


<210> 29407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29407
tcgtcacttc atttcaaatg                                                   20


<210> 29408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29408
atttcaaatg cagactgata                                                   20


<210> 29409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29409
tttcaaatgc agactgatat                                                   20


<210> 29410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29410
caaatgcaga ctgatatggg                                                   20


<210> 29411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29411
actgatatgg gtagaatgca                                                   20


<210> 29412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29412
tgatatgggt agaatgcaca                                                   20


<210> 29413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29413
gatatgggta gaatgcacag                                                   20


<210> 29414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29414
atatgggtag aatgcacaga                                                   20


<210> 29415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29415
tatgggtaga atgcacagag                                                   20


<210> 29416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29416
gggtagaatg cacagagggg                                                   20


<210> 29417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29417
ggtagaatgc acagagggga                                                   20


<210> 29418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29418
atgcacagag gggaaggctg                                                   20


<210> 29419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29419
tgcacagagg ggaaggctgt                                                   20


<210> 29420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29420
gcacagaggg gaaggctgta                                                   20


<210> 29421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29421
agaggggaag gctgtaggga                                                   20


<210> 29422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29422
ggggaaggct gtagggacag                                                   20


<210> 29423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29423
gggaaggctg tagggacagt                                                   20


<210> 29424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29424
ggctgtaggg acagtgggct                                                   20


<210> 29425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 29425
gtgggctgag actcacctcc                                                   20


<210> 29426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29426
tgggctgaga ctcacctccc                                                   20


<210> 29427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29427
actcacctcc cgggaatcaa                                                   20


<210> 29428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29428
ctgcatacat aatgtccatc                                                   20


<210> 29429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29429
taatgtccat ccagccttta                                                   20


<210> 29430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29430
aatgtccatc cagcctttaa                                                   20


<210> 29431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29431
tccagccttt aaaggttgcc                                                   20


<210> 29432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29432
cagcctttaa aggttgcctg                                                   20


<210> 29433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29433
tttaaaggtt gcctggagac                                                   20


<210> 29434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29434
ttaaaggttg cctggagaca                                                   20


<210> 29435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29435
aaaggttgcc tggagacaag                                                   20


<210> 29436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29436
ggttgcctgg agacaaggag                                                   20


<210> 29437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29437
ttgcctggag acaaggagca                                                   20


<210> 29438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29438
tgcctggaga caaggagcag                                                   20


<210> 29439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29439
gacaaggagc agaggccact                                                   20


<210> 29440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29440
gtctgcccat ccatctatac                                                   20


<210> 29441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29441
atctatactg gacccttccc                                                   20


<210> 29442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29442
actggaccct tcccaagcca                                                   20


<210> 29443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29443
ggacccttcc caagccatgg                                                   20


<210> 29444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29444
cttcccaagc catggtggcc                                                   20


<210> 29445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29445
ccaagccatg gtggcccagt                                                   20


<210> 29446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29446
aagccatggt ggcccagtga                                                   20


<210> 29447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29447
gccatggtgg cccagtgaga                                                   20


<210> 29448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29448
ccatggtggc ccagtgagag                                                   20


<210> 29449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29449
atggtggccc agtgagagag                                                   20


<210> 29450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29450
ggtggcccag tgagagagga                                                   20


<210> 29451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29451
tggcccagtg agagaggaga                                                   20


<210> 29452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29452
gagaggagag agtcctgtgt                                                   20


<210> 29453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29453
ggagagagtc ctgtgttgga                                                   20


<210> 29454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29454
gagagagtcc tgtgttggaa                                                   20


<210> 29455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29455
agagagtcct gtgttggaaa                                                   20


<210> 29456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29456
tgtgttggaa agggcttgtg                                                   20


<210> 29457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29457
ttggaaaggg cttgtgcaga                                                   20


<210> 29458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29458
ggcttgtgca gaaagaatga                                                   20


<210> 29459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29459
gcttgtgcag aaagaatgaa                                                   20


<210> 29460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29460
tgcagaaaga atgaaaggaa                                                   20


<210> 29461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29461
aatgaaagga aaagttccct                                                   20


<210> 29462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29462
atgaaaggaa aagttccctt                                                   20


<210> 29463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29463
taatctcata tgatgattta                                                   20


<210> 29464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29464
atttaaagta atcccacatg                                                   20


<210> 29465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29465
aatcccacat gtggctgttt                                                   20


<210> 29466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29466
cacatgtggc tgtttaagaa                                                   20


<210> 29467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29467
catgtggctg tttaagaata                                                   20


<210> 29468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29468
gtggctgttt aagaatagag                                                   20


<210> 29469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29469
ttaagaatag agtagcatta                                                   20


<210> 29470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29470
atagagtagc attaaagaca                                                   20


<210> 29471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29471
agagtagcat taaagacaca                                                   20


<210> 29472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29472
attaaagaca cagagccttt                                                   20


<210> 29473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29473
acacagagcc tttcagaatg                                                   20


<210> 29474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29474
gagcctttca gaatgtagta                                                   20


<210> 29475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29475
ttcagaatgt agtatggact                                                   20


<210> 29476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29476
tcagaatgta gtatggactg                                                   20


<210> 29477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29477
tgtagtatgg actgaggact                                                   20


<210> 29478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29478
tggactgagg actgagtgtc                                                   20


<210> 29479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29479
ggactgagga ctgagtgtct                                                   20


<210> 29480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29480
ggactgagtg tctaggtgtc                                                   20


<210> 29481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29481
agtgtctagg tgtctggttc                                                   20


<210> 29482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29482
gttctagtgc caattgctac                                                   20


<210> 29483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29483
tctgctctgt gcacttgcct                                                   20


<210> 29484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29484
ctgctctgtg cacttgccta                                                   20


<210> 29485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29485
ttgcctaagg tttcccctct                                                   20


<210> 29486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29486
tgcctaaggt ttcccctctc                                                   20


<210> 29487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29487
gcctaaggtt tcccctctca                                                   20


<210> 29488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29488
tctcagggct gccattttct                                                   20


<210> 29489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29489
ccaccttatg cacatgatgt                                                   20


<210> 29490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29490
ttatgcacat gatgtaagaa                                                   20


<210> 29491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29491
tgtaagaatg gtatatcttc                                                   20


<210> 29492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29492
agaatggtat atcttccaga                                                   20


<210> 29493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29493
aatggtatat cttccagatg                                                   20


<210> 29494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29494
ggtatatctt ccagatggag                                                   20


<210> 29495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29495
atcttccaga tggagaagtt                                                   20


<210> 29496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29496
ccagatggag aagttgagaa                                                   20


<210> 29497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29497
gatggagaag ttgagaatag                                                   20


<210> 29498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29498
gacctccatg ttcctgcctt                                                   20


<210> 29499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29499
catgttcctg ccttcagctt                                                   20


<210> 29500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29500
ccttcagctt tagcattctt                                                   20


<210> 29501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29501
cttcagcttt agcattcttg                                                   20


<210> 29502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29502
gctttagcat tcttgaggtc                                                   20


<210> 29503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29503
cattcttgag gtctagaaac                                                   20


<210> 29504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29504
attcttgagg tctagaaact                                                   20


<210> 29505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29505
tagaaactgg gtgtgccttc                                                   20


<210> 29506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29506
ggtgtgcctt ccagcatgtt                                                   20


<210> 29507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29507
tgtgccttcc agcatgttca                                                   20


<210> 29508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29508
ccagcatgtt cagagcatgc                                                   20


<210> 29509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29509
tcagagcatg caagacatct                                                   20


<210> 29510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29510
catcttagtt cttacactcc                                                   20


<210> 29511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29511
atcttagttc ttacactcct                                                   20


<210> 29512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29512
ttacactcct aggcctgtta                                                   20


<210> 29513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29513
ggcctgttac agcacttaat                                                   20


<210> 29514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29514
agctgtttta attcacctat                                                   20


<210> 29515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29515
ctattagtct gtttctcata                                                   20


<210> 29516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29516
gtctgtttct catacagcat                                                   20


<210> 29517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29517
ctcatacagc atcagtgtcc                                                   20


<210> 29518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29518
acagcatcag tgtccaagcc                                                   20


<210> 29519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29519
ccagttctga ctgtatctcc                                                   20


<210> 29520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29520
cagttctgac tgtatctccc                                                   20


<210> 29521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29521
agttctgact gtatctccca                                                   20


<210> 29522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29522
tgactgtatc tcccagggct                                                   20


<210> 29523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29523
ctgtatctcc cagggctgag                                                   20


<210> 29524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29524
gggctgagta gtaccatgcc                                                   20


<210> 29525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29525
tagtaccatg cctggcatac                                                   20


<210> 29526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29526
gtaccatgcc tggcatacca                                                   20


<210> 29527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29527
cctggcatac cagagctact                                                   20


<210> 29528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29528
tggcatacca gagctactca                                                   20


<210> 29529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29529
attatttgtt gaataaatgc                                                   20


<210> 29530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29530
tgaataaatg caagaaccaa                                                   20


<210> 29531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29531
ataaatgcaa gaaccaatgg                                                   20


<210> 29532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29532
caagaaccaa tggtggaatg                                                   20


<210> 29533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29533
atggtggaat gtagacactc                                                   20


<210> 29534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29534
ggtggaatgt agacactcaa                                                   20


<210> 29535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29535
taactgcatg acaaatgtat                                                   20


<210> 29536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29536
tgtattaaca cttgaatgaa                                                   20


<210> 29537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29537
tattaacact tgaatgaaca                                                   20


<210> 29538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29538
attaacactt gaatgaacag                                                   20


<210> 29539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29539
tgaacagagg actgaatgaa                                                   20


<210> 29540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29540
gaacagagga ctgaatgaac                                                   20


<210> 29541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29541
cagaggactg aatgaacagg                                                   20


<210> 29542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29542
actgaatgaa caggtagatg                                                   20


<210> 29543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29543
ctgaatgaac aggtagatga                                                   20


<210> 29544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29544
atgaacaggt agatgaaggc                                                   20


<210> 29545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29545
ggtagatgaa ggcaagaaat                                                   20


<210> 29546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29546
gcaagaaatg agtgattgac                                                   20


<210> 29547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29547
agtgattgac tggatgatga                                                   20


<210> 29548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29548
attgactgga tgatgaaaga                                                   20


<210> 29549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29549
actggatgat gaaagaaaga                                                   20


<210> 29550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29550
gatgatgaaa gaaagaaaga                                                   20


<210> 29551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29551
atgatgaaag aaagaaagac                                                   20


<210> 29552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29552
aacattatat atcattacaa                                                   20


<210> 29553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29553
atcattacaa tagacctaat                                                   20


<210> 29554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29554
agacataatt tattaccatt                                                   20


<210> 29555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29555
gacataattt attaccattt                                                   20


<210> 29556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29556
accatttagg aaatgatgtg                                                   20


<210> 29557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29557
taggaaatga tgtgaagttg                                                   20


<210> 29558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29558
gaagttgaag actgaacatg                                                   20


<210> 29559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29559
tatgccgtgt ctattttgta                                                   20


<210> 29560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29560
atgccgtgtc tattttgtac                                                   20


<210> 29561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29561
ctcaccacct gataatccca                                                   20


<210> 29562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29562
accacctgat aatcccatgg                                                   20


<210> 29563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29563
ccacctgata atcccatggc                                                   20


<210> 29564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29564
atccctttat gctattctac                                                   20


<210> 29565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29565
cactgtgata tcatattcac                                                   20


<210> 29566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29566
actgtgatat catattcact                                                   20


<210> 29567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29567
gtgatatcat attcactagg                                                   20


<210> 29568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29568
tgatatcata ttcactagga                                                   20


<210> 29569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29569
tattcactag gaaggccctc                                                   20


<210> 29570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29570
aggaaggccc tctagcctca                                                   20


<210> 29571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29571
ggccctctag cctcatggtg                                                   20


<210> 29572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29572
tagcctcatg gtgtagtctg                                                   20


<210> 29573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29573
agcctcatgg tgtagtctgt                                                   20


<210> 29574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29574
catggtgtag tctgtaggaa                                                   20


<210> 29575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29575
tggtgtagtc tgtaggaata                                                   20


<210> 29576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29576
gtaggaatag agaatgacct                                                   20


<210> 29577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29577
gaatgacctc agttcacact                                                   20


<210> 29578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29578
actgagtgct actccttgca                                                   20


<210> 29579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29579
ctccttgcaa agtccccaca                                                   20


<210> 29580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29580
agtccccaca tagcatcttc                                                   20


<210> 29581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29581
gtccccacat agcatcttct                                                   20


<210> 29582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29582
catagcatct tctgggaacc                                                   20


<210> 29583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29583
cctagactct ccattttatt                                                   20


<210> 29584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 29584
agactctcca ttttattgag                                                   20


<210> 29585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29585
tccattttat tgagcggcca                                                   20


<210> 29586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29586
ttttattgag cggccaaagc                                                   20


<210> 29587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29587
ttattgagcg gccaaagcaa                                                   20


<210> 29588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29588
agcggccaaa gcaagagata                                                   20


<210> 29589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29589
aagagatatg gttgatctca                                                   20


<210> 29590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29590
catggttgac tcaccacctg                                                   20


<210> 29591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29591
ggttgactca ccacctgcag                                                   20


<210> 29592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29592
ctcaccacct gcagaagtgc                                                   20


<210> 29593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29593
tcaccacctg cagaagtgca                                                   20


<210> 29594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29594
aacccattgc aacattatca                                                   20


<210> 29595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29595
agttgacttt cacattgacc                                                   20


<210> 29596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29596
tgactttcac attgacccag                                                   20


<210> 29597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29597
ctttcacatt gacccagaag                                                   20


<210> 29598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29598
attgacccag aagaagctgc                                                   20


<210> 29599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29599
gacccagaag aagctgccag                                                   20


<210> 29600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29600
cccagaagaa gctgccagtg                                                   20


<210> 29601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29601
cagtggagtt ttgaatcttg                                                   20


<210> 29602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29602
ggagttttga atcttgcagt                                                   20


<210> 29603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29603
cttgttattc acaatcgaca                                                   20


<210> 29604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29604
ttgttattca caatcgacaa                                                   20


<210> 29605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29605
ttcacaatcg acaaaggtac                                                   20


<210> 29606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29606
tcacaatcga caaaggtaca                                                   20


<210> 29607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29607
cacaatcgac aaaggtacaa                                                   20


<210> 29608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 29608
tacaagggaa aactctccat                                                   20


<210> 29609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29609
gggaaaactc tccatcggta                                                   20


<210> 29610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29610
acctccaaaa cttccctgcg                                                   20


<210> 29611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29611
ctccaaaact tccctgcgaa                                                   20


<210> 29612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29612
tccaaaactt ccctgcgaag                                                   20


<210> 29613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29613
ggttcacacc catgatgctg                                                   20


<210> 29614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29614
acacccatga tgctgaagat                                                   20


<210> 29615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29615
ccatgatgct gaagatgagc                                                   20


<210> 29616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29616
tgatgctgaa gatgagccag                                                   20


<210> 29617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29617
ctgaagatga gccagaagat                                                   20


<210> 29618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29618
tgaagatgag ccagaagatg                                                   20


<210> 29619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29619
agatgagcca gaagatgagg                                                   20


<210> 29620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29620
agccagaaga tgaggcagac                                                   20


<210> 29621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29621
gccagaagat gaggcagacg                                                   20


<210> 29622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29622
cagaagatga ggcagacgag                                                   20


<210> 29623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29623
agaagatgag gcagacgagg                                                   20


<210> 29624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29624
gacgaggagg acattcatga                                                   20


<210> 29625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29625
aggaggacat tcatgatgga                                                   20


<210> 29626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29626
ggaggacatt catgatggat                                                   20


<210> 29627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29627
gacattcatg atggatggga                                                   20


<210> 29628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29628
atggatggga tggcgcccac                                                   20


<210> 29629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29629
tggatgggat ggcgcccacc                                                   20


<210> 29630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29630
ggatgggatg gcgcccacca                                                   20


<210> 29631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29631
ccagggcatc caccaccacc                                                   20


<210> 29632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29632
gggcatccac caccacctgg                                                   20


<210> 29633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29633
ggcatccacc accacctggt                                                   20


<210> 29634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29634
catccaccac cacctggtgg                                                   20


<210> 29635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29635
caccaccacc tggtgggaga                                                   20


<210> 29636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29636
ccaccacctg gtgggagata                                                   20


<210> 29637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29637
cacctggtgg gagatagaga                                                   20


<210> 29638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29638
gtgggagata gagaaagacc                                                   20


<210> 29639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29639
caatgcccca ccccctctgc                                                   20


<210> 29640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29640
tatctctttc tatactcatt                                                   20


<210> 29641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29641
atctctttct atactcattc                                                   20


<210> 29642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29642
actcattcag gctgcttcat                                                   20


<210> 29643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29643
attcaggctg cttcatgagc                                                   20


<210> 29644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29644
caggctgctt catgagccag                                                   20


<210> 29645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29645
cttcatgagc cagtggcctt                                                   20


<210> 29646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29646
catgagccag tggcctttgg                                                   20


<210> 29647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29647
gagccagtgg cctttggaag                                                   20


<210> 29648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29648
cagtggcctt tggaagaagc                                                   20


<210> 29649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29649
gtggcctttg gaagaagcaa                                                   20


<210> 29650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29650
gcctttggaa gaagcaagag                                                   20


<210> 29651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29651
tttggaagaa gcaagagaag                                                   20


<210> 29652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29652
ttggaagaag caagagaagt                                                   20


<210> 29653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29653
agcaagagaa gtgggttaat                                                   20


<210> 29654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29654
ggttaattag tgcaataatt                                                   20


<210> 29655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29655
ttagtgcaat aattcagact                                                   20


<210> 29656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29656
gtgcaataat tcagactcag                                                   20


<210> 29657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29657
taattcagac tcagaagact                                                   20


<210> 29658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29658
attcagactc agaagactga                                                   20


<210> 29659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29659
ctcagaagac tgagagacat                                                   20


<210> 29660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29660
tcagaagact gagagacatt                                                   20


<210> 29661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29661
gaagactgag agacattggg                                                   20


<210> 29662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29662
tgagagacat tgggcagctg                                                   20


<210> 29663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29663
agacattggg cagctgaaga                                                   20


<210> 29664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29664
tgggcagctg aagatggatt                                                   20


<210> 29665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29665
cttcttccct taacctcatt                                                   20


<210> 29666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29666
ttcttccctt aacctcattc                                                   20


<210> 29667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29667
tcttccctta acctcattca                                                   20


<210> 29668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29668
tcccttaacc tcattcaggg                                                   20


<210> 29669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29669
cccttaacct cattcagggt                                                   20


<210> 29670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29670
acctcattca gggtgggttg                                                   20


<210> 29671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29671
cattcagggt gggttgcagt                                                   20


<210> 29672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29672
tcagggtggg ttgcagtgag                                                   20


<210> 29673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29673
ggtgggttgc agtgagaaga                                                   20


<210> 29674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29674
gttgcagtga gaagatggat                                                   20


<210> 29675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29675
gagaagatgg atgagtttac                                                   20


<210> 29676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29676
acaagcatac tgcactcatt                                                   20


<210> 29677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29677
agcatactgc actcatttag                                                   20


<210> 29678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29678
ctgcactcat ttagaagtgt                                                   20


<210> 29679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29679
gtgtattata cttgcacata                                                   20


<210> 29680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29680
tacttgcaca tacagacttc                                                   20


<210> 29681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29681
cacaatttaa atacaattta                                                   20


<210> 29682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29682
atacaattta aagtatgccg                                                   20


<210> 29683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29683
atttaaagta tgccgtggtc                                                   20


<210> 29684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29684
agtatgccgt ggtcaagaac                                                   20


<210> 29685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29685
ctaaatccat attcacaaaa                                                   20


<210> 29686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29686
aaaatagctt atttgtaaat                                                   20


<210> 29687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29687
ttatttgtaa ataagcaaat                                                   20


<210> 29688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29688
ataagcaaat gagaatctat                                                   20


<210> 29689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29689
agaatctatt agatacaaaa                                                   20


<210> 29690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 29690
tttcaaacta tttcaatctt                                                   20


<210> 29691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29691
ttcaaactat ttcaatcttc                                                   20


<210> 29692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29692
ctatttcaat cttcgggtcc                                                   20


<210> 29693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29693
ttcgggtcct agtgtttgta                                                   20


<210> 29694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29694
tcgggtccta gtgtttgtaa                                                   20


<210> 29695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29695
cctagtgttt gtaaaggtac                                                   20


<210> 29696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29696
aaggtacaag ttaatttcaa                                                   20


<210> 29697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29697
aaagcccact tttgtttttg                                                   20


<210> 29698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29698
gaagctatga tgactacttc                                                   20


<210> 29699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29699
tgactacttc cagccaatga                                                   20


<210> 29700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29700
ctacttccag ccaatgatag                                                   20


<210> 29701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29701
acttccagcc aatgatagtg                                                   20


<210> 29702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29702
cagccaatga tagtggagca                                                   20


<210> 29703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29703
agcaaaacct tactttctgc                                                   20


<210> 29704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29704
gcaaaacctt actttctgct                                                   20


<210> 29705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29705
caaaacctta ctttctgctg                                                   20


<210> 29706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29706
aaaccttact ttctgctggg                                                   20


<210> 29707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29707
ggggagccat ttgtaattat                                                   20


<210> 29708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29708
gggagccatt tgtaattatg                                                   20


<210> 29709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29709
agccatttgt aattatgagg                                                   20


<210> 29710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29710
ccatttgtaa ttatgaggaa                                                   20


<210> 29711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29711
catttgtaat tatgaggaag                                                   20


<210> 29712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29712
ttgtaattat gaggaagagg                                                   20


<210> 29713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29713
tgtaattatg aggaagaggt                                                   20


<210> 29714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29714
aggaagaggt gggtgtcaat                                                   20


<210> 29715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29715
ggtgtcaatc agcaatctct                                                   20


<210> 29716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29716
caatcagcaa tctctaagac                                                   20


<210> 29717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29717
aatcagcaat ctctaagaca                                                   20


<210> 29718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29718
caatctctaa gacaaggctc                                                   20


<210> 29719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29719
taagacaagg ctctggctgt                                                   20


<210> 29720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 29720
ctgtgagcat tctgtcctga                                                   20


<210> 29721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29721
gtgagcattc tgtcctgacg                                                   20


<210> 29722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29722
tgagcattct gtcctgacgg                                                   20


<210> 29723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29723
gcattctgtc ctgacggagg                                                   20


<210> 29724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29724
tctgtcctga cggaggcagt                                                   20


<210> 29725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29725
ctgtcctgac ggaggcagtt                                                   20


<210> 29726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29726
tgtcctgacg gaggcagtta                                                   20


<210> 29727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29727
ctgacggagg cagttagggc                                                   20


<210> 29728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29728
tgacggaggc agttagggca                                                   20


<210> 29729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29729
cggaggcagt tagggcaagg                                                   20


<210> 29730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29730
gaggcagtta gggcaaggtg                                                   20


<210> 29731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29731
aggcagttag ggcaaggtgg                                                   20


<210> 29732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29732
tagggcaagg tggaggctga                                                   20


<210> 29733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29733
ggcaaggtgg aggctgacag                                                   20


<210> 29734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29734
aaggtggagg ctgacagtgg                                                   20


<210> 29735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29735
ggaggctgac agtggtggat                                                   20


<210> 29736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29736
gaggctgaca gtggtggata                                                   20


<210> 29737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29737
ctgacagtgg tggataagga                                                   20


<210> 29738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29738
tgacagtggt ggataaggaa                                                   20


<210> 29739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29739
gacagtggtg gataaggaaa                                                   20


<210> 29740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29740
acagtggtgg ataaggaaag                                                   20


<210> 29741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29741
gtggtggata aggaaagggg                                                   20


<210> 29742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29742
tggataagga aaggggtgga                                                   20


<210> 29743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29743
ataaggaaag gggtggatgg                                                   20


<210> 29744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29744
taaggaaagg ggtggatgga                                                   20


<210> 29745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29745
aaggaaaggg gtggatggaa                                                   20


<210> 29746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29746
ggatggaagg gaaaaattta                                                   20


<210> 29747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29747
gatggaaggg aaaaatttac                                                   20


<210> 29748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29748
caggacctga tgattgcatt                                                   20


<210> 29749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29749
gacctgatga ttgcattaag                                                   20


<210> 29750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29750
acctgatgat tgcattaagt                                                   20


<210> 29751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29751
ctgatgattg cattaagtag                                                   20


<210> 29752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29752
gatgattgca ttaagtagga                                                   20


<210> 29753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29753
gattgcatta agtaggagag                                                   20


<210> 29754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29754
tgcattaagt aggagagaag                                                   20


<210> 29755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29755
gtaggagaga agaagcattc                                                   20


<210> 29756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29756
ggagagaaga agcattccag                                                   20


<210> 29757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29757
gagagaagaa gcattccagt                                                   20


<210> 29758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29758
agaagaagca ttccagtggg                                                   20


<210> 29759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29759
agaagcattc cagtgggtgg                                                   20


<210> 29760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29760
cattccagtg ggtggcagct                                                   20


<210> 29761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29761
attccagtgg gtggcagctg                                                   20


<210> 29762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29762
tgggtggcag ctgaggtaat                                                   20


<210> 29763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29763
tgagctgatg atgtcactca                                                   20


<210> 29764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29764
agctgatgat gtcactcatg                                                   20


<210> 29765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29765
tgatgtcact catggagtat                                                   20


<210> 29766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29766
atgtcactca tggagtatta                                                   20


<210> 29767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29767
tgtcactcat ggagtattag                                                   20


<210> 29768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29768
actcatggag tattagagga                                                   20


<210> 29769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29769
gaggaaagac tcatttgtca                                                   20


<210> 29770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29770
aaagactcat ttgtcatgga                                                   20


<210> 29771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29771
actcatttgt catggaaaga                                                   20


<210> 29772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29772
tcatttgtca tggaaagaca                                                   20


<210> 29773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29773
tcatggaaag acagagaact                                                   20


<210> 29774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29774
catggaaaga cagagaactt                                                   20


<210> 29775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29775
acagagaact tgggatgttc                                                   20


<210> 29776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29776
agagaacttg ggatgttctg                                                   20


<210> 29777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29777
ttgggatgtt ctggagatgt                                                   20


<210> 29778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29778
gttctggaga tgttggcaat                                                   20


<210> 29779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29779
tctggagatg ttggcaataa                                                   20


<210> 29780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29780
ctggagatgt tggcaataag                                                   20


<210> 29781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29781
gagatgttgg caataagagg                                                   20


<210> 29782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29782
gatgttggca ataagaggca                                                   20


<210> 29783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29783
ttggcaataa gaggcagagt                                                   20


<210> 29784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29784
tggcaataag aggcagagtt                                                   20


<210> 29785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29785
agaggcagag ttgggtgatt                                                   20


<210> 29786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29786
gagttgggtg attgagataa                                                   20


<210> 29787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29787
attgagataa tagatgcttg                                                   20


<210> 29788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29788
tgagataata gatgcttgtg                                                   20


<210> 29789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29789
atgcttgtgg agcgatgatt                                                   20


<210> 29790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29790
tgcttgtgga gcgatgattc                                                   20


<210> 29791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29791
tgattcagga ttacttcact                                                   20


<210> 29792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29792
attcaggatt acttcactaa                                                   20


<210> 29793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29793
ggattacttc actaagagca                                                   20


<210> 29794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29794
gattacttca ctaagagcaa                                                   20


<210> 29795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29795
attacttcac taagagcaaa                                                   20


<210> 29796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29796
ttacttcact aagagcaaag                                                   20


<210> 29797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29797
tacttcacta agagcaaagg                                                   20


<210> 29798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29798
tcactaagag caaagggggt                                                   20


<210> 29799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29799
cactaagagc aaagggggtg                                                   20


<210> 29800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29800
agagcaaagg gggtgaggtc                                                   20


<210> 29801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29801
gagcaaaggg ggtgaggtct                                                   20


<210> 29802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29802
agggggtgag gtctgggtcc                                                   20


<210> 29803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29803
gggtgaggtc tgggtcctgg                                                   20


<210> 29804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29804
cctggtggct gtaatattta                                                   20


<210> 29805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29805
ctggtggctg taatatttat                                                   20


<210> 29806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29806
ctgtaatatt tatgggtgac                                                   20


<210> 29807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29807
tgtaatattt atgggtgaca                                                   20


<210> 29808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29808
gtaatattta tgggtgacaa                                                   20


<210> 29809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29809
atatttatgg gtgacaaggg                                                   20


<210> 29810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29810
ttatgggtga caagggaaga                                                   20


<210> 29811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29811
tatgggtgac aagggaagat                                                   20


<210> 29812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29812
agggaagatg ggcccacaaa                                                   20


<210> 29813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29813
gggcccacaa aaagacttga                                                   20


<210> 29814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29814
gcccacaaaa agacttgaaa                                                   20


<210> 29815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29815
aaaagacttg aaagagaact                                                   20


<210> 29816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29816
aagacttgaa agagaactaa                                                   20


<210> 29817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29817
gacttgaaag agaactaaga                                                   20


<210> 29818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29818
tgaaagagaa ctaagagagt                                                   20


<210> 29819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29819
gaaagagaac taagagagtt                                                   20


<210> 29820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29820
actaagagag ttaggacatg                                                   20


<210> 29821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29821
taggacatgc agcaccacca                                                   20


<210> 29822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29822
acatgcagca ccaccaaagt                                                   20


<210> 29823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29823
atgcagcacc accaaagtca                                                   20


<210> 29824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29824
cagcaccacc aaagtcagag                                                   20


<210> 29825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29825
agcaccacca aagtcagagc                                                   20


<210> 29826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29826
accaccaaag tcagagcagg                                                   20


<210> 29827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29827
caaagtcaga gcaggaagtg                                                   20


<210> 29828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29828
cagagcagga agtgaagact                                                   20


<210> 29829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29829
gagcaggaag tgaagactca                                                   20


<210> 29830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29830
gaagactcag agcctacctt                                                   20


<210> 29831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29831
agactcagag cctacctttg                                                   20


<210> 29832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29832
gactcagagc ctacctttgg                                                   20


<210> 29833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29833
tcagagccta cctttggagg                                                   20


<210> 29834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29834
cagagcctac ctttggaggt                                                   20


<210> 29835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29835
agagcctacc tttggaggtg                                                   20


<210> 29836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 29836
tacctttgga ggtggggccc                                                   20


<210> 29837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29837
cctttggagg tggggccccg                                                   20


<210> 29838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29838
ggaggtgggg ccccggagct                                                   20


<210> 29839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29839
gaggtggggc cccggagctc                                                   20


<210> 29840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29840
aggtggggcc ccggagctca                                                   20


<210> 29841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29841
ggggccccgg agctcagggt                                                   20


<210> 29842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29842
gccccggagc tcagggttgg                                                   20


<210> 29843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29843
ccccggagct cagggttggt                                                   20


<210> 29844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29844
ggagctcagg gttggtggga                                                   20


<210> 29845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29845
agctcagggt tggtgggatg                                                   20


<210> 29846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29846
gctcagggtt ggtgggatgg                                                   20


<210> 29847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29847
ctcagggttg gtgggatgga                                                   20


<210> 29848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29848
ttggtgggat ggagggcata                                                   20


<210> 29849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29849
tggtgggatg gagggcataa                                                   20


<210> 29850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29850
ggtgggatgg agggcataaa                                                   20


<210> 29851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29851
gtgggatgga gggcataaag                                                   20


<210> 29852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29852
tgggatggag ggcataaagg                                                   20


<210> 29853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29853
gatggagggc ataaaggggg                                                   20


<210> 29854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29854
atggagggca taaaggggga                                                   20


<210> 29855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29855
tggagggcat aaagggggaa                                                   20


<210> 29856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29856
ggaagggtta ccaaaacctg                                                   20


<210> 29857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29857
ggttaccaaa acctgcagac                                                   20


<210> 29858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29858
ttaccaaaac ctgcagacca                                                   20


<210> 29859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29859
ccaaaacctg cagaccagag                                                   20


<210> 29860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29860
aagttttttg tttgtttttt                                                   20


<210> 29861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29861
agttttttgt ttgttttttg                                                   20


<210> 29862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 29862
tttttgtttg ttttttgagg                                                   20


<210> 29863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29863
tttgtttgtt ttttgaggcg                                                   20


<210> 29864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29864
cggagtctcg ctctgtcacc                                                   20


<210> 29865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29865
ggagtctcgc tctgtcaccc                                                   20


<210> 29866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29866
tctcgctctg tcacccaggc                                                   20


<210> 29867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29867
tcgctctgtc acccaggctg                                                   20


<210> 29868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29868
tcacccaggc tggagtataa                                                   20


<210> 29869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 29869
ggagtataat ggcacaatct                                                   20


<210> 29870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29870
ctcactacca ccacacctcg                                                   20


<210> 29871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29871
actaccacca cacctcgtgg                                                   20


<210> 29872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29872
accaccacac ctcgtggtgg                                                   20


<210> 29873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29873
ggtagtgatt tttgtacttt                                                   20


<210> 29874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29874
agtgattttt gtacttttag                                                   20


<210> 29875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29875
tgatttttgt acttttagca                                                   20


<210> 29876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29876
ttttgtactt ttagcagaga                                                   20


<210> 29877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29877
tttgtacttt tagcagagac                                                   20


<210> 29878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29878
ttgtactttt agcagagaca                                                   20


<210> 29879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 29879
ttttagcaga gacagggttt                                                   20


<210> 29880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29880
gagacagggt ttcggcatgt                                                   20


<210> 29881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29881
cagggtttcg gcatgttggc                                                   20


<210> 29882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29882
agggtttcgg catgttggcc                                                   20


<210> 29883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29883
gggtttcggc atgttggcca                                                   20


<210> 29884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29884
tttcggcatg ttggccaggg                                                   20


<210> 29885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29885
tggttttgaa ctcctaacct                                                   20


<210> 29886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29886
ggttttgaac tcctaacctc                                                   20


<210> 29887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29887
ctcaggtgat ccgcccgcct                                                   20


<210> 29888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29888
ccgcccgcct cagcctccca                                                   20


<210> 29889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29889
gcctcagcct cccaaagtgc                                                   20


<210> 29890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29890
cctcagcctc ccaaagtgct                                                   20


<210> 29891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29891
ctcccaaagt gctgggatta                                                   20


<210> 29892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29892
tcccaaagtg ctgggattac                                                   20


<210> 29893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29893
caggcatgaa ccaccgtgcc                                                   20


<210> 29894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29894
catgaaccac cgtgcctggc                                                   20


<210> 29895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29895
accaccgtgc ctggccagat                                                   20


<210> 29896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29896
caccgtgcct ggccagatga                                                   20


<210> 29897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29897
cgtgcctggc cagatgagag                                                   20


<210> 29898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29898
ggccagatga gagaagtttt                                                   20


<210> 29899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29899
gatgagagaa gttttgagat                                                   20


<210> 29900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29900
tacccgcatg ccttcaaatc                                                   20


<210> 29901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29901
cgcatgcctt caaatcgaga                                                   20


<210> 29902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29902
catgccttca aatcgagaaa                                                   20


<210> 29903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29903
tcaaatcgag aaagagcccg                                                   20


<210> 29904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29904
aatcgagaaa gagcccgcag                                                   20


<210> 29905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29905
gaaagagccc gcagtggccg                                                   20


<210> 29906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29906
aagagcccgc agtggccgca                                                   20


<210> 29907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29907
cgcagtggcc gcagagcgcg                                                   20


<210> 29908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29908
gcagtggccg cagagcgcga                                                   20


<210> 29909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29909
cagtggccgc agagcgcgaa                                                   20


<210> 29910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29910
cgcagagcgc gaagggttcg                                                   20


<210> 29911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29911
gcagagcgcg aagggttcga                                                   20


<210> 29912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29912
cagagcgcga agggttcgaa                                                   20


<210> 29913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29913
aagggttcga agggctttga                                                   20


<210> 29914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29914
agggttcgaa gggctttgat                                                   20


<210> 29915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29915
ggttcgaagg gctttgatgg                                                   20


<210> 29916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29916
ggctttgatg ggagccactt                                                   20


<210> 29917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29917
ggagccactt cagaatattc                                                   20


<210> 29918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29918
tattccagaa tcttcgctgt                                                   20


<210> 29919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29919
atcttcgctg tgagacttat                                                   20


<210> 29920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29920
tcgctgtgag acttatcagt                                                   20


<210> 29921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29921
gagacttatc agtgagatct                                                   20


<210> 29922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29922
ttatcagtga gatctgagtg                                                   20


<210> 29923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29923
tatcagtgag atctgagtgc                                                   20


<210> 29924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29924
tcagtgagat ctgagtgcag                                                   20


<210> 29925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29925
agtgagatct gagtgcagga                                                   20


<210> 29926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29926
gtgagatctg agtgcaggag                                                   20


<210> 29927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29927
tgagatctga gtgcaggaga                                                   20


<210> 29928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29928
gatctgagtg caggagaggg                                                   20


<210> 29929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29929
agagggcaga aacatcactc                                                   20


<210> 29930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29930
gagggcagaa acatcactct                                                   20


<210> 29931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29931
gaaacatcac tctaggtttc                                                   20


<210> 29932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29932
catcactcta ggtttccaga                                                   20


<210> 29933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29933
atcactctag gtttccagaa                                                   20


<210> 29934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29934
actctaggtt tccagaaagg                                                   20


<210> 29935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29935
ttccagaaag gcagtcctcg                                                   20


<210> 29936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29936
cagaaaggca gtcctcgtgg                                                   20


<210> 29937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29937
agaaaggcag tcctcgtgga                                                   20


<210> 29938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29938
aaaggcagtc ctcgtggaag                                                   20


<210> 29939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29939
gcagtcctcg tggaaggaga                                                   20


<210> 29940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29940
cagtcctcgt ggaaggagac                                                   20


<210> 29941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29941
ggagacagga actccctgcc                                                   20


<210> 29942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29942
cctcccattc ctacacgtct                                                   20


<210> 29943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29943
acacgtctaa gccatcatcc                                                   20


<210> 29944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CGG

<400> 29944
atcctagctc ccaccttatt                                                   20


<210> 29945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29945
accttattcg gaactccaat                                                   20


<210> 29946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29946
cttattcgga actccaatga                                                   20


<210> 29947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29947
ttattcggaa ctccaatgag                                                   20


<210> 29948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29948
cggaactcca atgagaggtc                                                   20


<210> 29949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29949
actccaatga gaggtctaga                                                   20


<210> 29950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29950
tccaatgaga ggtctagaaa                                                   20


<210> 29951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29951
caccactctc ttaaacaatc                                                   20


<210> 29952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29952
accactctct taaacaatct                                                   20


<210> 29953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29953
ctctcttaaa caatctgggc                                                   20


<210> 29954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29954
caatctgggc aagaaaaact                                                   20


<210> 29955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29955
tctctaacat caccaacctc                                                   20


<210> 29956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29956
catcaccaac ctctggtacg                                                   20


<210> 29957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29957
atcaccaacc tctggtacgt                                                   20


<210> 29958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29958
accaacctct ggtacgtagg                                                   20


<210> 29959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29959
cctctggtac gtaggtggcc                                                   20


<210> 29960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29960
tacgtaggtg gccaagcttc                                                   20


<210> 29961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29961
tcaactcttc cttttccttc                                                   20


<210> 29962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29962
caactcttcc ttttccttct                                                   20


<210> 29963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29963
aactcttcct tttccttcta                                                   20


<210> 29964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29964
actcttcctt ttccttctag                                                   20


<210> 29965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29965
cttccttttc cttctagggg                                                   20


<210> 29966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29966
ccttttcctt ctaggggcag                                                   20


<210> 29967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29967
ttccttctag gggcagcagt                                                   20


<210> 29968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29968
tccttctagg ggcagcagtc                                                   20


<210> 29969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29969
acaaccttga aactgatttt                                                   20


<210> 29970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29970
aaccttgaaa ctgattttca                                                   20


<210> 29971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29971
gaaactgatt ttcagagact                                                   20


<210> 29972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29972
aactgatttt cagagacttg                                                   20


<210> 29973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29973
ggagacatga tgttccctcc                                                   20


<210> 29974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29974
gagacatgat gttccctcct                                                   20


<210> 29975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29975
agacatgatg ttccctccta                                                   20


<210> 29976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29976
gacatgatgt tccctcctag                                                   20


<210> 29977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29977
tccctcctag gggctatgct                                                   20


<210> 29978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29978
cctcctaggg gctatgctga                                                   20


<210> 29979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29979
ctatgctgag agtctattct                                                   20


<210> 29980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AGG

<400> 29980
tatgctgaga gtctattctg                                                   20


<210> 29981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29981
agagtctatt ctgaggaata                                                   20


<210> 29982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: CAG

<400> 29982
taatctgaat tatatttgct                                                   20


<210> 29983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29983
atctgaatta tatttgctca                                                   20


<210> 29984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29984
tgaattatat ttgctcagag                                                   20


<210> 29985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29985
attatatttg ctcagagaag                                                   20


<210> 29986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29986
ttatatttgc tcagagaagt                                                   20


<210> 29987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29987
tatatttgct cagagaagtg                                                   20


<210> 29988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29988
atttgctcag agaagtgggg                                                   20


<210> 29989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: AAG

<400> 29989
gctcagagaa gtggggtgga                                                   20


<210> 29990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 29990
gagaagtggg gtggaaagaa                                                   20


<210> 29991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29991
aagtggggtg gaaagaatag                                                   20


<210> 29992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29992
gggtggaaag aatagtggtt                                                   20


<210> 29993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29993
ggtggaaaga atagtggttt                                                   20


<210> 29994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29994
ggaaagaata gtggtttggg                                                   20


<210> 29995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29995
gaaagaatag tggtttgggt                                                   20


<210> 29996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29996
aaagaatagt ggtttgggtg                                                   20


<210> 29997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GAG

<400> 29997
tttgaaccct gattttttgt                                                   20


<210> 29998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TGG

<400> 29998
accctgattt tttgtgagct                                                   20


<210> 29999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: GGG

<400> 29999
ccctgatttt ttgtgagctt                                                   20


<210> 30000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN10A; (+) strand; PAM type: NRG;
      PAM sequence: TAG

<400> 30000
gattttttgt gagcttgggt                                                   20

